-- dump date 20250517_150157 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GeneID -- field 3 chrom_position -- field 4 chromosome -- field 5 codon_start -- field 6 contig -- field 7 description -- field 8 end_pos -- field 9 gene -- field 10 gene_id -- field 11 name -- field 12 organism -- field 13 product -- field 14 protein_id -- field 15 start_pos -- field 16 strand -- field 17 taxid -- field 18 type -- header -- id GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type LALA0_S01e00100g 34683341 complement(2..181) Unknown 1 NW_019212879.1 some similarities with uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; 181 34683341 LALA0_S01e00100g Lachancea lanzarotensis 2 R 1245769 CDS LALA0_S01e00122g 34683342 complement(2089..3333) Unknown 1 NW_019212879.1 similar to Lachancea thermotolerans KLTH0E03080g hypothetical protein; uncharacterized protein 3333 34683342 LALA0_S01e00122g Lachancea lanzarotensis uncharacterized protein XP_022626219.1 2089 R 1245769 CDS LALA0_S01e00144g 34683343 complement(join(4449..4574,4574..4780,4780..4935)) Unknown 1 NW_019212879.1 some similarities with uniprot|L9PLA9 Janthinobacterium sp. HH01 Jab_1c02220 NAD-dependent epimerase/dehydratase; 4935 34683343 LALA0_S01e00144g Lachancea lanzarotensis 4449 R 1245769 CDS LALA0_S01e00166g 34683344 complement(5407..6822) Unknown 1 NW_019212879.1 similar to uniprot|P35842 Saccharomyces cerevisiae YAR071W PHO11 One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; uncharacterized protein 6822 34683344 LALA0_S01e00166g Lachancea lanzarotensis uncharacterized protein XP_022626220.1 5407 R 1245769 CDS LALA0_S01e00188g 34683345 7796..9757 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; uncharacterized protein 9757 34683345 LALA0_S01e00188g Lachancea lanzarotensis uncharacterized protein XP_022626221.1 7796 D 1245769 CDS LALA0_S01e00210g 34683346 complement(12767..14611) Unknown 1 NW_019212879.1 similar to uniprot|Q08912 Saccharomyces cerevisiae YOR389W Putative protein of unknown function; expression regulated by copper levels; uncharacterized protein 14611 34683346 LALA0_S01e00210g Lachancea lanzarotensis uncharacterized protein XP_022626222.1 12767 R 1245769 CDS LALA0_S01e00232g 34683347 complement(15969..16571) Unknown 1 NW_019212879.1 hypothetical protein; 16571 34683347 LALA0_S01e00232g Lachancea lanzarotensis 15969 R 1245769 CDS LALA0_S01e00254g 34683348 18304..19062 Unknown 1 NW_019212879.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 19062 34683348 LALA0_S01e00254g Lachancea lanzarotensis uncharacterized protein XP_022626223.1 18304 D 1245769 CDS LALA0_S01e00276g 34683349 20593..21390 Unknown 1 NW_019212879.1 highly similar to uniprot|G8YIZ4 Millerozyma farinosa Piso0_003402 hypothetical protein; uncharacterized protein 21390 34683349 LALA0_S01e00276g Lachancea lanzarotensis uncharacterized protein XP_022626224.1 20593 D 1245769 CDS LALA0_S01e00298g 34683350 complement(21612..23621) Unknown 1 NW_019212879.1 weakly similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment; uncharacterized protein 23621 34683350 LALA0_S01e00298g Lachancea lanzarotensis uncharacterized protein XP_022626225.1 21612 R 1245769 CDS LALA0_S01e00320g 34683351 24035..25498 Unknown 1 NW_019212879.1 similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); uncharacterized protein 25498 34683351 LALA0_S01e00320g Lachancea lanzarotensis uncharacterized protein XP_022626226.1 24035 D 1245769 CDS LALA0_S01e00342g 34683352 26343..30185 Unknown 1 NW_019212879.1 highly similar to uniprot|P28273 Saccharomyces cerevisiae YKL215C OXP1 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; 5-oxoprolinase 30185 34683352 LALA0_S01e00342g Lachancea lanzarotensis 5-oxoprolinase XP_022626227.1 26343 D 1245769 CDS LALA0_S01e00364g 34683353 32527..33723 Unknown 1 NW_019212879.1 similar to uniprot|P43623 Saccharomyces cerevisiae YFR055W IRC7 Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner; uncharacterized protein 33723 34683353 LALA0_S01e00364g Lachancea lanzarotensis uncharacterized protein XP_022626228.1 32527 D 1245769 CDS LALA0_S01e00386g 34683354 35976..37541 Unknown 1 NW_019212879.1 similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W YHK8 Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles; uncharacterized protein 37541 34683354 LALA0_S01e00386g Lachancea lanzarotensis uncharacterized protein XP_022626229.1 35976 D 1245769 CDS LALA0_S01e00408g 34683355 complement(38943..39971) Unknown 1 NW_019212879.1 weakly similar to uniprot|P25608 Saccharomyces cerevisiae YCR102C Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family; uncharacterized protein 39971 34683355 LALA0_S01e00408g Lachancea lanzarotensis uncharacterized protein XP_022626230.1 38943 R 1245769 CDS LALA0_S01e00430g 34683356 complement(41320..42693) Unknown 1 NW_019212879.1 similar to uniprot|O94493 Schizosaccharomyces pombe carboxylesterase-lipase family protein; uncharacterized protein 42693 34683356 LALA0_S01e00430g Lachancea lanzarotensis uncharacterized protein XP_022626231.1 41320 R 1245769 CDS LALA0_S01e00452g 34683357 complement(43501..44379) Unknown 1 NW_019212879.1 weakly similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; uncharacterized protein 44379 34683357 LALA0_S01e00452g Lachancea lanzarotensis uncharacterized protein XP_022626232.1 43501 R 1245769 CDS LALA0_S01e00474g 34683358 45696..47447 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase; uncharacterized protein 47447 34683358 LALA0_S01e00474g Lachancea lanzarotensis uncharacterized protein XP_022626233.1 45696 D 1245769 CDS LALA0_S01e00496g 34683359 complement(47803..49803) Unknown 1 NW_019212879.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; uncharacterized protein 49803 34683359 LALA0_S01e00496g Lachancea lanzarotensis uncharacterized protein XP_022626234.1 47803 R 1245769 CDS LALA0_S01e00518g 34683360 50428..51984 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase; uncharacterized protein 51984 34683360 LALA0_S01e00518g Lachancea lanzarotensis uncharacterized protein XP_022626235.1 50428 D 1245769 CDS LALA0_S01e00540g 34683361 complement(52821..54368) Unknown 1 NW_019212879.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 54368 34683361 LALA0_S01e00540g Lachancea lanzarotensis uncharacterized protein XP_022626236.1 52821 R 1245769 CDS LALA0_S01e00562g 34683362 54961..56595 Unknown 1 NW_019212879.1 similar to Tatumella ptyseos 1-aminocyclopropane-1-carboxylate deaminase; uncharacterized protein 56595 34683362 LALA0_S01e00562g Lachancea lanzarotensis uncharacterized protein XP_022626237.1 54961 D 1245769 CDS LALA0_S01e00584g 34683363 complement(57314..59377) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; uncharacterized protein 59377 34683363 LALA0_S01e00584g Lachancea lanzarotensis uncharacterized protein XP_022626238.1 57314 R 1245769 CDS LALA0_S01e00606g 34683364 complement(59798..61489) Unknown 1 NW_019212879.1 weakly similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions; uncharacterized protein 61489 34683364 LALA0_S01e00606g Lachancea lanzarotensis uncharacterized protein XP_022626239.1 59798 R 1245769 CDS LALA0_S01e00628g 34683365 complement(61713..62729) Unknown 1 NW_019212879.1 highly similar to uniprot|C5DIZ1 Lachancea thermotolerans KLTH0E16302g hypothetical protein; uncharacterized protein 62729 34683365 LALA0_S01e00628g Lachancea lanzarotensis uncharacterized protein XP_022626240.1 61713 R 1245769 CDS LALA0_S01e00650g 34683366 63197..64795 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 64795 34683366 LALA0_S01e00650g Lachancea lanzarotensis uncharacterized protein XP_022626241.1 63197 D 1245769 CDS LALA0_S01e00672g 34683367 complement(65275..67044) Unknown 1 NW_019212879.1 highly similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C IMA1 Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family; uncharacterized protein 67044 34683367 LALA0_S01e00672g Lachancea lanzarotensis uncharacterized protein XP_022626242.1 65275 R 1245769 CDS LALA0_S01e00694g 34683368 complement(69595..71211) Unknown 1 NW_019212879.1 highly similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; uncharacterized protein 71211 34683368 LALA0_S01e00694g Lachancea lanzarotensis uncharacterized protein XP_022626243.1 69595 R 1245769 CDS LALA0_S01e00716g 34683369 72955..74793 Unknown 1 NW_019212879.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; siderophore transporter 74793 34683369 LALA0_S01e00716g Lachancea lanzarotensis siderophore transporter XP_022626244.1 72955 D 1245769 CDS LALA0_S01e00738g 34683370 75701..76498 Unknown 1 NW_019212879.1 similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 76498 34683370 LALA0_S01e00738g Lachancea lanzarotensis uncharacterized protein XP_022626245.1 75701 D 1245769 CDS LALA0_S01e00760g 34683371 complement(77199..78893) Unknown 1 NW_019212879.1 similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C (ohnolog of YNL270C) CAN1 Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; uncharacterized protein 78893 34683371 LALA0_S01e00760g Lachancea lanzarotensis uncharacterized protein XP_022626246.1 77199 R 1245769 CDS LALA0_S01e00782g 34683372 complement(79953..81494) Unknown 1 NW_019212879.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 81494 34683372 LALA0_S01e00782g Lachancea lanzarotensis uncharacterized protein XP_022626247.1 79953 R 1245769 CDS LALA0_S01e00804g 34683373 complement(82119..83168) Unknown 1 NW_019212879.1 similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; uncharacterized protein 83168 34683373 LALA0_S01e00804g Lachancea lanzarotensis uncharacterized protein XP_022626248.1 82119 R 1245769 CDS LALA0_S01e00826g 34683374 complement(83485..86082) Unknown 1 NW_019212879.1 similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p; uncharacterized protein 86082 34683374 LALA0_S01e00826g Lachancea lanzarotensis uncharacterized protein XP_022626249.1 83485 R 1245769 CDS LALA0_S01e00848g 34683375 86297..86776 Unknown 1 NW_019212879.1 similar to uniprot|P11747 Saccharomyces cerevisiae YML098W TAF13 TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors; uncharacterized protein 86776 34683375 LALA0_S01e00848g Lachancea lanzarotensis uncharacterized protein XP_022626250.1 86297 D 1245769 CDS LALA0_S01e00870g 34683376 complement(88298..90223) Unknown 1 NW_019212879.1 similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum; ER oxidoreductin 90223 34683376 LALA0_S01e00870g Lachancea lanzarotensis ER oxidoreductin XP_022626251.1 88298 R 1245769 CDS LALA0_S01e00892g 34683377 complement(90492..91844) Unknown 1 NW_019212879.1 similar to uniprot|P54787 Saccharomyces cerevisiae YML097C VPS9 A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin; guanine nucleotide exchange factor VPS9 91844 34683377 LALA0_S01e00892g Lachancea lanzarotensis guanine nucleotide exchange factor VPS9 XP_022626252.1 90492 R 1245769 CDS LALA0_S01e00914g 34683378 91979..93532 Unknown 1 NW_019212879.1 similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10; uncharacterized protein 93532 34683378 LALA0_S01e00914g Lachancea lanzarotensis uncharacterized protein XP_022626253.1 91979 D 1245769 CDS LALA0_S01e00936g 34683379 complement(93582..94250) Unknown 1 NW_019212879.1 similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; DNA repair protein RAD10 94250 34683379 LALA0_S01e00936g Lachancea lanzarotensis DNA repair protein RAD10 XP_022626254.1 93582 R 1245769 CDS LALA0_S01e00958g 34683380 join(94937..94952,95017..95465) Unknown 1 NW_019212879.1 similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; uncharacterized protein 95465 34683380 LALA0_S01e00958g Lachancea lanzarotensis uncharacterized protein XP_022626255.1 94937 D 1245769 CDS LALA0_S01e00980g 34683381 95738..98338 Unknown 1 NW_019212879.1 similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; uncharacterized protein 98338 34683381 LALA0_S01e00980g Lachancea lanzarotensis uncharacterized protein XP_022626256.1 95738 D 1245769 CDS LALA0_S01e01002g 34683382 complement(join(98462..99170,99328..99371)) Unknown 1 NW_019212879.1 highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 Alpha 2 subunit of the 20S proteasome; proteasome core particle subunit alpha 2 99371 34683382 LALA0_S01e01002g Lachancea lanzarotensis proteasome core particle subunit alpha 2 XP_022626257.1 98462 R 1245769 CDS LALA0_S01e01024g 34683383 complement(join(99796..100303,100379..100407)) Unknown 1 NW_019212879.1 similar to uniprot|C5DIZ0 Lachancea thermotolerans KLTH0E16280g hypothetical protein; uncharacterized protein 100407 34683383 LALA0_S01e01024g Lachancea lanzarotensis uncharacterized protein XP_022626258.1 99796 R 1245769 CDS LALA0_S01e01046g 34683384 join(100528..100572,100639..101283) Unknown 1 NW_019212879.1 similar to uniprot|C5DIX2 Lachancea thermotolerans KLTH0E15862g hypothetical protein; uncharacterized protein 101283 34683384 LALA0_S01e01046g Lachancea lanzarotensis uncharacterized protein XP_022626259.1 100528 D 1245769 CDS LALA0_S01e01068g 34683385 complement(101463..101648) Unknown 1 NW_019212879.1 similar to uniprot|P39103 Saccharomyces cerevisiae YML129C COX14 Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; uncharacterized protein 101648 34683385 LALA0_S01e01068g Lachancea lanzarotensis uncharacterized protein XP_022626260.1 101463 R 1245769 CDS LALA0_S01e01090g 34683386 complement(102068..103990) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated; uncharacterized protein 103990 34683386 LALA0_S01e01090g Lachancea lanzarotensis uncharacterized protein XP_022626261.1 102068 R 1245769 CDS LALA0_S01e01112g 34683387 106708..108453 Unknown 1 NW_019212879.1 similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; uncharacterized protein 108453 34683387 LALA0_S01e01112g Lachancea lanzarotensis uncharacterized protein XP_022626262.1 106708 D 1245769 CDS LALA0_S01e01134g 34683388 complement(108687..112355) Unknown 1 NW_019212879.1 similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus; ribonuclease P 112355 34683388 LALA0_S01e01134g Lachancea lanzarotensis ribonuclease P XP_022626263.1 108687 R 1245769 CDS LALA0_S01e01156g 34683389 complement(112970..114364) Unknown 1 NW_019212879.1 highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis; hydroxymethylglutaryl-CoA synthase 114364 34683389 LALA0_S01e01156g Lachancea lanzarotensis hydroxymethylglutaryl-CoA synthase XP_022626264.1 112970 R 1245769 CDS LALA0_S01e01200g 34683391 complement(115594..119277) Unknown 1 NW_019212879.1 similar to uniprot|P35845 Saccharomyces cerevisiae YAR042W (ohnolog of YDL019C) SWH1 Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction; uncharacterized protein 119277 34683391 LALA0_S01e01200g Lachancea lanzarotensis uncharacterized protein XP_022626265.1 115594 R 1245769 CDS LALA0_S01e01222g 34683392 complement(119774..121735) Unknown 1 NW_019212879.1 similar to uniprot|P80235 Saccharomyces cerevisiae YAR035W YAT1 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated; carnitine O-acetyltransferase YAT1 121735 34683392 LALA0_S01e01222g Lachancea lanzarotensis carnitine O-acetyltransferase YAT1 XP_022626266.1 119774 R 1245769 CDS LALA0_S01e01244g 34683393 122906..125527 Unknown 1 NW_019212879.1 similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; serine/threonine protein kinase CDC15 125527 34683393 LALA0_S01e01244g Lachancea lanzarotensis serine/threonine protein kinase CDC15 XP_022626267.1 122906 D 1245769 CDS LALA0_S01e01266g 34683394 125718..126938 Unknown 1 NW_019212879.1 similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential serine/threonine protein kinase; possible role in DNA damage response; serine/threonine protein kinase KIN3 126938 34683394 LALA0_S01e01266g Lachancea lanzarotensis serine/threonine protein kinase KIN3 XP_022626268.1 125718 D 1245769 CDS LALA0_S01e01288g 34683395 complement(127039..127953) Unknown 1 NW_019212879.1 highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; phosphoribosylaminoimidazolesuccinocarboxamide synthase 127953 34683395 LALA0_S01e01288g Lachancea lanzarotensis phosphoribosylaminoimidazolesuccinocarboxamide synthase XP_022626269.1 127039 R 1245769 CDS LALA0_S01e01310g 34683396 128963..131008 Unknown 1 NW_019212879.1 weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; protein phosphatase regulator BUD14 131008 34683396 LALA0_S01e01310g Lachancea lanzarotensis protein phosphatase regulator BUD14 XP_022626270.1 128963 D 1245769 CDS LALA0_S01e01332g 34683397 131359..134073 Unknown 1 NW_019212879.1 similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis; uncharacterized protein 134073 34683397 LALA0_S01e01332g Lachancea lanzarotensis uncharacterized protein XP_022626271.1 131359 D 1245769 CDS LALA0_S01e01354g 34683398 134812..136461 Unknown 1 NW_019212879.1 similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; allantoinase 136461 34683398 LALA0_S01e01354g Lachancea lanzarotensis allantoinase XP_022626272.1 134812 D 1245769 CDS LALA0_S01e01376g 34683399 complement(136606..137262) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C ERP3 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; uncharacterized protein 137262 34683399 LALA0_S01e01376g Lachancea lanzarotensis uncharacterized protein XP_022626273.1 136606 R 1245769 CDS LALA0_S01e01398g 34683400 137447..138859 Unknown 1 NW_019212879.1 similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; serine/threonine protein kinase CDC7 138859 34683400 LALA0_S01e01398g Lachancea lanzarotensis serine/threonine protein kinase CDC7 XP_022626274.1 137447 D 1245769 CDS LALA0_S01e01420g 34683401 complement(138934..139851) Unknown 1 NW_019212879.1 similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p; trans-2-enoyl-CoA reductase (NADPH) TSC13 139851 34683401 LALA0_S01e01420g Lachancea lanzarotensis trans-2-enoyl-CoA reductase (NADPH) TSC13 XP_022626275.1 138934 R 1245769 CDS LALA0_S01e01442g 34683402 join(141841..141877,142130..143073) Unknown 1 NW_019212879.1 highly similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W NOP1 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin; rRNA methyltransferase NOP1 143073 34683402 LALA0_S01e01442g Lachancea lanzarotensis rRNA methyltransferase NOP1 XP_022626276.1 141841 D 1245769 CDS LALA0_S01e01464g 34683403 143513..145237 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W SLX5 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers; SUMO-targeted ubiquitin ligase complex subunit SLX5 145237 34683403 LALA0_S01e01464g Lachancea lanzarotensis SUMO-targeted ubiquitin ligase complex subunit SLX5 XP_022626277.1 143513 D 1245769 CDS LALA0_S01e01486g 34683404 145413..146537 Unknown 1 NW_019212879.1 similar to uniprot|C5DIV3 Lachancea thermotolerans KLTH0E15444g hypothetical protein; uncharacterized protein 146537 34683404 LALA0_S01e01486g Lachancea lanzarotensis uncharacterized protein XP_022626278.1 145413 D 1245769 CDS LALA0_S01e01508g 34683405 complement(join(146700..147008,147134..147181)) Unknown 1 NW_019212879.1 similar to uniprot|P38216 Saccharomyces cerevisiae YBR016W (ohnolog of YDL012C) Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; uncharacterized protein 147181 34683405 LALA0_S01e01508g Lachancea lanzarotensis uncharacterized protein XP_022626279.1 146700 R 1245769 CDS LALA0_S01e01530g 34683406 147986..149320 Unknown 1 NW_019212879.1 weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene; uncharacterized protein 149320 34683406 LALA0_S01e01530g Lachancea lanzarotensis uncharacterized protein XP_022626280.1 147986 D 1245769 CDS LALA0_S01e01552g 34683407 complement(149384..149926) Unknown 1 NW_019212879.1 similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene; uncharacterized protein 149926 34683407 LALA0_S01e01552g Lachancea lanzarotensis uncharacterized protein XP_022626281.1 149384 R 1245769 CDS LALA0_S01e01574g 34683408 complement(150302..154063) Unknown 1 NW_019212879.1 similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Putative ABC transporter; uncharacterized protein 154063 34683408 LALA0_S01e01574g Lachancea lanzarotensis uncharacterized protein XP_022626282.1 150302 R 1245769 CDS LALA0_S01e01596g 34683409 155333..155896 Unknown 1 NW_019212879.1 similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding; tubulin-binding prefolding complex subunit PAC10 155896 34683409 LALA0_S01e01596g Lachancea lanzarotensis tubulin-binding prefolding complex subunit PAC10 XP_022626283.1 155333 D 1245769 CDS LALA0_S01e01618g 34683410 complement(155949..156791) Unknown 1 NW_019212879.1 similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Putative protein of unknown function; uncharacterized protein 156791 34683410 LALA0_S01e01618g Lachancea lanzarotensis uncharacterized protein XP_022626284.1 155949 R 1245769 CDS LALA0_S01e01640g 34683411 156932..158650 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p; uncharacterized protein 158650 34683411 LALA0_S01e01640g Lachancea lanzarotensis uncharacterized protein XP_022626285.1 156932 D 1245769 CDS LALA0_S01e01662g 34683412 158960..160006 Unknown 1 NW_019212879.1 highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; protein-arginine omega-N methyltransferase HMT1 160006 34683412 LALA0_S01e01662g Lachancea lanzarotensis protein-arginine omega-N methyltransferase HMT1 XP_022626286.1 158960 D 1245769 CDS LALA0_S01e01684g 34683413 complement(160240..161334) Unknown 1 NW_019212879.1 highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W (ohnolog of YBR031W) RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins; 60S ribosomal protein uL4 161334 34683413 LALA0_S01e01684g Lachancea lanzarotensis 60S ribosomal protein uL4 XP_022626287.1 160240 R 1245769 CDS LALA0_S01e01706g 34683414 complement(161765..163558) Unknown 1 NW_019212879.1 highly similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; amino acid permease GAP1 163558 34683414 LALA0_S01e01706g Lachancea lanzarotensis amino acid permease GAP1 XP_022626288.1 161765 R 1245769 CDS LALA0_S01e01728g 34683415 166188..167345 Unknown 1 NW_019212879.1 highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; tRNA N6-adenosine threonylcarbamoyltransferase 167345 34683415 LALA0_S01e01728g Lachancea lanzarotensis tRNA N6-adenosine threonylcarbamoyltransferase XP_022626289.1 166188 D 1245769 CDS LALA0_S01e01750g 34683416 167547..168365 Unknown 1 NW_019212879.1 similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body; uncharacterized protein 168365 34683416 LALA0_S01e01750g Lachancea lanzarotensis uncharacterized protein XP_022626290.1 167547 D 1245769 CDS LALA0_S01e01772g 34683417 168729..170906 Unknown 1 NW_019212879.1 similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W (ohnolog of YKR036C) MDV1 Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; uncharacterized protein 170906 34683417 LALA0_S01e01772g Lachancea lanzarotensis uncharacterized protein XP_022626291.1 168729 D 1245769 CDS LALA0_S01e01794g 34683418 171405..173060 Unknown 1 NW_019212879.1 highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance; chaperonin-containing T-complex subunit CCT7 173060 34683418 LALA0_S01e01794g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT7 XP_022626292.1 171405 D 1245769 CDS LALA0_S01e01816g 34683419 complement(173187..173801) Unknown 1 NW_019212879.1 highly similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors; uncharacterized protein 173801 34683419 LALA0_S01e01816g Lachancea lanzarotensis uncharacterized protein XP_022626293.1 173187 R 1245769 CDS LALA0_S01e01838g 34683420 complement(174646..176541) Unknown 1 NW_019212879.1 weakly similar to uniprot|P42944 Saccharomyces cerevisiae YJL110C (ohnolog of YKR034W) GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; uncharacterized protein 176541 34683420 LALA0_S01e01838g Lachancea lanzarotensis uncharacterized protein XP_022626294.1 174646 R 1245769 CDS LALA0_S01e01860g 34683421 179295..183908 Unknown 1 NW_019212879.1 similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; phospholipase D 183908 34683421 LALA0_S01e01860g Lachancea lanzarotensis phospholipase D XP_022626295.1 179295 D 1245769 CDS LALA0_S01e01882g 34683422 184542..186389 Unknown 1 NW_019212879.1 similar to uniprot|C5DIV2 Lachancea thermotolerans KLTH0E15422g hypothetical protein; uncharacterized protein 186389 34683422 LALA0_S01e01882g Lachancea lanzarotensis uncharacterized protein XP_022626296.1 184542 D 1245769 CDS LALA0_S01e01904g 34683423 187089..187502 Unknown 1 NW_019212879.1 similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein; uncharacterized protein 187502 34683423 LALA0_S01e01904g Lachancea lanzarotensis uncharacterized protein XP_022626297.1 187089 D 1245769 CDS LALA0_S01e01926g 34683424 complement(187600..188334) Unknown 1 NW_019212879.1 similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; uncharacterized protein 188334 34683424 LALA0_S01e01926g Lachancea lanzarotensis uncharacterized protein XP_022626298.1 187600 R 1245769 CDS LALA0_S01e01948g 34683425 complement(188620..193920) Unknown 1 NW_019212879.1 similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance; snoRNA-binding rRNA-processing protein UTP10 193920 34683425 LALA0_S01e01948g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein UTP10 XP_022626299.1 188620 R 1245769 CDS LALA0_S01e01970g 34683426 complement(194349..197195) Unknown 1 NW_019212879.1 some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation; pheromone-regulated protein PRM10 197195 34683426 LALA0_S01e01970g Lachancea lanzarotensis pheromone-regulated protein PRM10 XP_022626300.1 194349 R 1245769 CDS LALA0_S01e02036g 34683427 200372..201340 Unknown 1 NW_019212879.1 similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; uncharacterized protein 201340 34683427 LALA0_S01e02036g Lachancea lanzarotensis uncharacterized protein XP_022626301.1 200372 D 1245769 CDS LALA0_S01e02058g 34683428 join(201717..201751,201810..202083) Unknown 1 NW_019212879.1 similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C ER-localized protein of unknown function; uncharacterized protein 202083 34683428 LALA0_S01e02058g Lachancea lanzarotensis uncharacterized protein XP_022626302.1 201717 D 1245769 CDS LALA0_S01e02080g 34683429 202723..203577 Unknown 1 NW_019212879.1 similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C JID1 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae; uncharacterized protein 203577 34683429 LALA0_S01e02080g Lachancea lanzarotensis uncharacterized protein XP_022626303.1 202723 D 1245769 CDS LALA0_S01e02102g 34683430 204505..205278 Unknown 1 NW_019212879.1 highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; chorismate mutase ARO7 205278 34683430 LALA0_S01e02102g Lachancea lanzarotensis chorismate mutase ARO7 XP_022626304.1 204505 D 1245769 CDS LALA0_S01e02124g 34683431 complement(205399..206310) Unknown 1 NW_019212879.1 similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p; organic acid transporter 206310 34683431 LALA0_S01e02124g Lachancea lanzarotensis organic acid transporter XP_022626305.1 205399 R 1245769 CDS LALA0_S01e02146g 34683432 207157..207582 Unknown 1 NW_019212879.1 highly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes; uncharacterized protein 207582 34683432 LALA0_S01e02146g Lachancea lanzarotensis uncharacterized protein XP_022626306.1 207157 D 1245769 CDS LALA0_S01e02168g 34683433 join(208316..208352,208717..209060) Unknown 1 NW_019212879.1 highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C (ohnolog of YER056C-A) RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein; 60S ribosomal protein eL34 209060 34683433 LALA0_S01e02168g Lachancea lanzarotensis 60S ribosomal protein eL34 XP_022626307.1 208316 D 1245769 CDS LALA0_S01e02190g 34683434 209525..209818 Unknown 1 NW_019212879.1 similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase; uncharacterized protein 209818 34683434 LALA0_S01e02190g Lachancea lanzarotensis uncharacterized protein XP_022626308.1 209525 D 1245769 CDS LALA0_S01e02212g 34683435 210570..211985 Unknown 1 NW_019212879.1 some similarities with uniprot|P40186 Saccharomyces cerevisiae YIL050W (ohnolog of YER059W) PCL7 Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; uncharacterized protein 211985 34683435 LALA0_S01e02212g Lachancea lanzarotensis uncharacterized protein XP_022626309.1 210570 D 1245769 CDS LALA0_S01e02234g 34683436 215077..216633 Unknown 1 NW_019212879.1 similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; uncharacterized protein 216633 34683436 LALA0_S01e02234g Lachancea lanzarotensis uncharacterized protein XP_022626310.1 215077 D 1245769 CDS LALA0_S01e02256g 34683437 222495..223259 Unknown 1 NW_019212879.1 similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); uncharacterized protein 223259 34683437 LALA0_S01e02256g Lachancea lanzarotensis uncharacterized protein XP_022626311.1 222495 D 1245769 CDS LALA0_S01e02278g 34683438 complement(223290..224567) Unknown 1 NW_019212879.1 similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration; fatty acid synthase CEM1 224567 34683438 LALA0_S01e02278g Lachancea lanzarotensis fatty acid synthase CEM1 XP_022626312.1 223290 R 1245769 CDS LALA0_S01e02300g 34683439 226186..226821 Unknown 1 NW_019212879.1 weakly similar to Lachancea thermotolerans KLTH0D10516g hypothetical protein; uncharacterized protein 226821 34683439 LALA0_S01e02300g Lachancea lanzarotensis uncharacterized protein XP_022626313.1 226186 D 1245769 CDS LALA0_S01e02322g 34683440 complement(227408..228157) Unknown 1 NW_019212879.1 highly similar to uniprot|P41277 Saccharomyces cerevisiae YIL053W (ohnolog of YER062C HOR2) RHR2 Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress; uncharacterized protein 228157 34683440 LALA0_S01e02322g Lachancea lanzarotensis uncharacterized protein XP_022626314.1 227408 R 1245769 CDS LALA0_S01e02344g 34683441 230198..230791 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation; uncharacterized protein 230791 34683441 LALA0_S01e02344g Lachancea lanzarotensis uncharacterized protein XP_022626315.1 230198 D 1245769 CDS LALA0_S01e02366g 34683442 231487..232677 Unknown 1 NW_019212879.1 some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Putative protein of unknown function; uncharacterized protein 232677 34683442 LALA0_S01e02366g Lachancea lanzarotensis uncharacterized protein XP_022626316.1 231487 D 1245769 CDS LALA0_S01e02388g 34683443 complement(232916..234829) Unknown 1 NW_019212879.1 similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W (ohnolog of YER064C) VHR1 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; uncharacterized protein 234829 34683443 LALA0_S01e02388g Lachancea lanzarotensis uncharacterized protein XP_022626317.1 232916 R 1245769 CDS LALA0_S01e02410g 34683444 complement(235111..236766) Unknown 1 NW_019212879.1 highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; isocitrate lyase 1 236766 34683444 LALA0_S01e02410g Lachancea lanzarotensis isocitrate lyase 1 XP_022626318.1 235111 R 1245769 CDS LALA0_S01e02454g 34683446 240613..241134 Unknown 1 NW_019212879.1 similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C (ohnolog of YER067W) RGI2 Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; uncharacterized protein 241134 34683446 LALA0_S01e02454g Lachancea lanzarotensis uncharacterized protein XP_022626319.1 240613 D 1245769 CDS LALA0_S01e02476g 34683447 241703..243607 Unknown 1 NW_019212879.1 similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT core ubiquitin-protein ligase subunit MOT2 243607 34683447 LALA0_S01e02476g Lachancea lanzarotensis CCR4-NOT core ubiquitin-protein ligase subunit MOT2 XP_022626320.1 241703 D 1245769 CDS LALA0_S01e02498g 34683448 243891..244790 Unknown 1 NW_019212879.1 similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; U1 snRNP complex subunit SNP1 244790 34683448 LALA0_S01e02498g Lachancea lanzarotensis U1 snRNP complex subunit SNP1 XP_022626321.1 243891 D 1245769 CDS LALA0_S01e02520g 34683449 245326..247893 Unknown 1 NW_019212879.1 highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5,6 Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p; bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase 247893 34683449 LALA0_S01e02520g Lachancea lanzarotensis bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase XP_022626322.1 245326 D 1245769 CDS LALA0_S01e02542g 34683450 248490..248951 Unknown 1 NW_019212879.1 highly similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity; uncharacterized protein 248951 34683450 LALA0_S01e02542g Lachancea lanzarotensis uncharacterized protein XP_022626323.1 248490 D 1245769 CDS LALA0_S01e02564g 34683451 249170..250408 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential; uncharacterized protein 250408 34683451 LALA0_S01e02564g Lachancea lanzarotensis uncharacterized protein XP_022626324.1 249170 D 1245769 CDS LALA0_S01e02586g 34683452 complement(250556..251248) Unknown 1 NW_019212879.1 similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W SEE1 Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport; uncharacterized protein 251248 34683452 LALA0_S01e02586g Lachancea lanzarotensis uncharacterized protein XP_022626325.1 250556 R 1245769 CDS LALA0_S01e02608g 34683453 251471..251935 Unknown 1 NW_019212879.1 similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation; uncharacterized protein 251935 34683453 LALA0_S01e02608g Lachancea lanzarotensis uncharacterized protein XP_022626326.1 251471 D 1245769 CDS LALA0_S01e02630g 34683454 252888..255536 Unknown 1 NW_019212879.1 highly similar to uniprot|P21672 Saccharomyces cerevisiae YIL066C (ohnolog of YER070W) RNR3 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; uncharacterized protein 255536 34683454 LALA0_S01e02630g Lachancea lanzarotensis uncharacterized protein XP_022626327.1 252888 D 1245769 CDS LALA0_S01e02652g 34683455 255905..257920 Unknown 1 NW_019212879.1 similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Uncharacterized protein of unknown function; uncharacterized protein 257920 34683455 LALA0_S01e02652g Lachancea lanzarotensis uncharacterized protein XP_022626328.1 255905 D 1245769 CDS LALA0_S01e02674g 34683456 258039..260432 Unknown 1 NW_019212879.1 similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly; SNARE-binding exocyst subunit SEC6 260432 34683456 LALA0_S01e02674g Lachancea lanzarotensis SNARE-binding exocyst subunit SEC6 XP_022626329.1 258039 D 1245769 CDS LALA0_S01e02696g 34683457 complement(260464..260811) Unknown 1 NW_019212879.1 similar to uniprot|P40045 Saccharomyces cerevisiae YER071C TDA2 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele; uncharacterized protein 260811 34683457 LALA0_S01e02696g Lachancea lanzarotensis uncharacterized protein XP_022626330.1 260464 R 1245769 CDS LALA0_S01e02718g 34683458 261328..261699 Unknown 1 NW_019212879.1 highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; uncharacterized protein 261699 34683458 LALA0_S01e02718g Lachancea lanzarotensis uncharacterized protein XP_022626331.1 261328 D 1245769 CDS LALA0_S01e02762g 34683460 263070..264626 Unknown 1 NW_019212879.1 highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; aldehyde dehydrogenase (NAD(P)(+)) ALD5 264626 34683460 LALA0_S01e02762g Lachancea lanzarotensis aldehyde dehydrogenase (NAD(P)(+)) ALD5 XP_022626332.1 263070 D 1245769 CDS LALA0_S01e02784g 34683461 join(265675..265677,266127..266531) Unknown 1 NW_019212879.1 highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C (ohnolog of YER074W) RPS24B Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein; 40S ribosomal protein eS24 266531 34683461 LALA0_S01e02784g Lachancea lanzarotensis 40S ribosomal protein eS24 XP_022626333.1 265675 D 1245769 CDS LALA0_S01e02806g 34683462 join(266878..266968,267051..267208) Unknown 1 NW_019212879.1 similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p; uncharacterized protein 267208 34683462 LALA0_S01e02806g Lachancea lanzarotensis uncharacterized protein XP_022626334.1 266878 D 1245769 CDS LALA0_S01e02828g 34683463 complement(267484..270030) Unknown 1 NW_019212879.1 similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm; tyrosine protein phosphatase PTP3 270030 34683463 LALA0_S01e02828g Lachancea lanzarotensis tyrosine protein phosphatase PTP3 XP_022626335.1 267484 R 1245769 CDS LALA0_S01e02850g 34683464 272224..273012 Unknown 1 NW_019212879.1 similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R; uncharacterized protein 273012 34683464 LALA0_S01e02850g Lachancea lanzarotensis uncharacterized protein XP_022626336.1 272224 D 1245769 CDS LALA0_S01e02872g 34683465 complement(273086..275020) Unknown 1 NW_019212879.1 similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport; uncharacterized protein 275020 34683465 LALA0_S01e02872g Lachancea lanzarotensis uncharacterized protein XP_022626337.1 273086 R 1245769 CDS LALA0_S01e02894g 34683466 275237..276424 Unknown 1 NW_019212879.1 similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain; uncharacterized protein 276424 34683466 LALA0_S01e02894g Lachancea lanzarotensis uncharacterized protein XP_022626338.1 275237 D 1245769 CDS LALA0_S01e02916g 34683467 complement(276498..278069) Unknown 1 NW_019212879.1 similar to uniprot|P40051 Saccharomyces cerevisiae YER078C ICP55 Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family; aminopeptidase 278069 34683467 LALA0_S01e02916g Lachancea lanzarotensis aminopeptidase XP_022626339.1 276498 R 1245769 CDS LALA0_S01e02938g 34683468 complement(join(278301..279369,279439..280157)) Unknown 1 NW_019212879.1 similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation; uncharacterized protein 280157 34683468 LALA0_S01e02938g Lachancea lanzarotensis uncharacterized protein XP_022626340.1 278301 R 1245769 CDS LALA0_S01e02960g 34683469 281184..281897 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Putative protein of unknown function; uncharacterized protein 281897 34683469 LALA0_S01e02960g Lachancea lanzarotensis uncharacterized protein XP_022626341.1 281184 D 1245769 CDS LALA0_S01e02982g 34683470 282350..284209 Unknown 1 NW_019212879.1 similar to uniprot|P40053 Saccharomyces cerevisiae YER080W AIM9 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 284209 34683470 LALA0_S01e02982g Lachancea lanzarotensis uncharacterized protein XP_022626342.1 282350 D 1245769 CDS LALA0_S01e03004g 34683471 284981..286393 Unknown 1 NW_019212879.1 highly similar to uniprot|P40510 Saccharomyces cerevisiae YIL074C (ohnolog of YER081W) SER33 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p; uncharacterized protein 286393 34683471 LALA0_S01e03004g Lachancea lanzarotensis uncharacterized protein XP_022626343.1 284981 D 1245769 CDS LALA0_S01e03026g 34683472 286746..289580 Unknown 1 NW_019212879.1 highly similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p; proteasome regulatory particle base subunit RPN2 289580 34683472 LALA0_S01e03026g Lachancea lanzarotensis proteasome regulatory particle base subunit RPN2 XP_022626344.1 286746 D 1245769 CDS LALA0_S01e03048g 34683473 complement(289719..291383) Unknown 1 NW_019212879.1 highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C UTP7 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 291383 34683473 LALA0_S01e03048g Lachancea lanzarotensis uncharacterized protein XP_022626345.1 289719 R 1245769 CDS LALA0_S01e03070g 34683474 293343..294236 Unknown 1 NW_019212879.1 similar to uniprot|Q03028 Saccharomyces cerevisiae YPL134C (ohnolog of YOR222W) ODC1 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; mitochondrial 2-oxodicarboxylate carrier 294236 34683474 LALA0_S01e03070g Lachancea lanzarotensis mitochondrial 2-oxodicarboxylate carrier XP_022626346.1 293343 D 1245769 CDS LALA0_S01e03092g 34683475 294836..295600 Unknown 1 NW_019212879.1 similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Protein of unknown function found in the ER and vacuole lumen; overexpression of YOR223W affects endocytic protein trafficking; uncharacterized protein 295600 34683475 LALA0_S01e03092g Lachancea lanzarotensis uncharacterized protein XP_022626347.1 294836 D 1245769 CDS LALA0_S01e03114g 34683476 complement(295705..296334) Unknown 1 NW_019212879.1 highly similar to uniprot|C5DEZ1 Lachancea thermotolerans KLTH0D10912g hypothetical protein; uncharacterized protein 296334 34683476 LALA0_S01e03114g Lachancea lanzarotensis uncharacterized protein XP_022626348.1 295705 R 1245769 CDS LALA0_S01e03136g 34683477 complement(297133..297567) Unknown 1 NW_019212879.1 highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III; DNA-directed RNA polymerase core subunit RPB8 297567 34683477 LALA0_S01e03136g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPB8 XP_022626349.1 297133 R 1245769 CDS LALA0_S01e03158g 34683478 complement(297952..298428) Unknown 1 NW_019212879.1 highly similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W (ohnolog of YOR226C) ISU1 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable; uncharacterized protein 298428 34683478 LALA0_S01e03158g Lachancea lanzarotensis uncharacterized protein XP_022626350.1 297952 R 1245769 CDS LALA0_S01e03180g 34683479 300138..303431 Unknown 1 NW_019212879.1 similar to uniprot|Q03016 Saccharomyces cerevisiae YPL137C (ohnolog of YOR227W) GIP3 Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; uncharacterized protein 303431 34683479 LALA0_S01e03180g Lachancea lanzarotensis uncharacterized protein XP_022626351.1 300138 D 1245769 CDS LALA0_S01e03202g 34683480 complement(303560..304408) Unknown 1 NW_019212879.1 similar to uniprot|Q12106 Saccharomyces cerevisiae YOR228C Protein of unknown function, localized to the mitochondrial outer membrane; uncharacterized protein 304408 34683480 LALA0_S01e03202g Lachancea lanzarotensis uncharacterized protein XP_022626352.1 303560 R 1245769 CDS LALA0_S01e03224g 34683481 306118..307134 Unknown 1 NW_019212879.1 similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C SPP1 Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; uncharacterized protein 307134 34683481 LALA0_S01e03224g Lachancea lanzarotensis uncharacterized protein XP_022626353.1 306118 D 1245769 CDS LALA0_S01e03246g 34683482 join(307441..307447,307537..308876) Unknown 1 NW_019212879.1 similar to uniprot|Q03010 Saccharomyces cerevisiae YPL139C (ohnolog of YOR229W) UME1 Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p; uncharacterized protein 308876 34683482 LALA0_S01e03246g Lachancea lanzarotensis uncharacterized protein XP_022626354.1 307441 D 1245769 CDS LALA0_S01e03268g 34683483 310007..311377 Unknown 1 NW_019212879.1 similar to uniprot|P32491 Saccharomyces cerevisiae YPL140C (ohnolog of YOR231W) MKK2 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; mitogen-activated protein kinase kinase MKK1 311377 34683483 LALA0_S01e03268g Lachancea lanzarotensis mitogen-activated protein kinase kinase MKK1 XP_022626355.1 310007 D 1245769 CDS LALA0_S01e03290g 34683484 311979..312674 Unknown 1 NW_019212879.1 similar to uniprot|P38523 Saccharomyces cerevisiae YOR232W MGE1 Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE; uncharacterized protein 312674 34683484 LALA0_S01e03290g Lachancea lanzarotensis uncharacterized protein XP_022626356.1 311979 D 1245769 CDS LALA0_S01e03312g 34683485 313420..316044 Unknown 1 NW_019212879.1 similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C (ohnolog of YOR233W) FRK1 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3; uncharacterized protein 316044 34683485 LALA0_S01e03312g Lachancea lanzarotensis uncharacterized protein XP_022626357.1 313420 D 1245769 CDS LALA0_S01e03334g 34683486 complement(join(316330..316634,317086..317104)) Unknown 1 NW_019212879.1 highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W (ohnolog of YOR234C) RPL33A N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; 60S ribosomal protein eL33 317104 34683486 LALA0_S01e03334g Lachancea lanzarotensis 60S ribosomal protein eL33 XP_022626358.1 316330 R 1245769 CDS LALA0_S01e03356g 34683487 complement(318785..319165) Unknown 1 NW_019212879.1 similar to uniprot|Q12245 Saccharomyces cerevisiae YPL144W POC4 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; uncharacterized protein 319165 34683487 LALA0_S01e03356g Lachancea lanzarotensis uncharacterized protein XP_022626359.1 318785 R 1245769 CDS LALA0_S01e03378g 34683488 319873..320511 Unknown 1 NW_019212879.1 similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function; dihydrofolate reductase 320511 34683488 LALA0_S01e03378g Lachancea lanzarotensis dihydrofolate reductase XP_022626360.1 319873 D 1245769 CDS LALA0_S01e03400g 34683489 321377..322630 Unknown 1 NW_019212879.1 highly similar to uniprot|P35844 Saccharomyces cerevisiae YPL145C (ohnolog of YOR237W) KES1 Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; oxysterol-binding protein KES1 322630 34683489 LALA0_S01e03400g Lachancea lanzarotensis oxysterol-binding protein KES1 XP_022626361.1 321377 D 1245769 CDS LALA0_S01e03422g 34683490 323068..324420 Unknown 1 NW_019212879.1 similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired; uncharacterized protein 324420 34683490 LALA0_S01e03422g Lachancea lanzarotensis uncharacterized protein XP_022626362.1 323068 D 1245769 CDS LALA0_S01e03444g 34683491 324728..325609 Unknown 1 NW_019212879.1 similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 325609 34683491 LALA0_S01e03444g Lachancea lanzarotensis uncharacterized protein XP_022626363.1 324728 D 1245769 CDS LALA0_S01e03466g 34683492 complement(325606..328098) Unknown 1 NW_019212879.1 similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins; ATP-binding cassette long-chain fatty acid transporter PXA1 328098 34683492 LALA0_S01e03466g Lachancea lanzarotensis ATP-binding cassette long-chain fatty acid transporter PXA1 XP_022626364.1 325606 R 1245769 CDS LALA0_S01e03488g 34683493 330408..331271 Unknown 1 NW_019212879.1 highly similar to Lachancea thermotolerans KLTH0D10934g hypothetical protein; uncharacterized protein 331271 34683493 LALA0_S01e03488g Lachancea lanzarotensis uncharacterized protein XP_022626365.1 330408 D 1245769 CDS LALA0_S01e03510g 34683494 331873..332538 Unknown 1 NW_019212879.1 similar to uniprot|C5DEZ5 Lachancea thermotolerans KLTH0D11022g hypothetical protein; uncharacterized protein 332538 34683494 LALA0_S01e03510g Lachancea lanzarotensis uncharacterized protein XP_022626366.1 331873 D 1245769 CDS LALA0_S01e03532g 34683495 333008..333526 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation; holo-[acyl-carrier-protein] synthase 333526 34683495 LALA0_S01e03532g Lachancea lanzarotensis holo-[acyl-carrier-protein] synthase XP_022626367.1 333008 D 1245769 CDS LALA0_S01e03554g 34683496 join(333836..334588,334590..335600) Unknown 1 NW_019212879.1 similar to uniprot|Q08641 Saccharomyces cerevisiae YOR239W ABP140 AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift; tRNA(Thr) (cytosine(32)-N(3))-methyltransferase 335600 34683496 LALA0_S01e03554g Lachancea lanzarotensis tRNA(Thr) (cytosine(32)-N(3))-methyltransferase XP_022626368.1 333836 D 1245769 CDS LALA0_S01e03576g 34683497 complement(335686..336579) Unknown 1 NW_019212879.1 similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation; uncharacterized protein 336579 34683497 LALA0_S01e03576g Lachancea lanzarotensis uncharacterized protein XP_022626369.1 335686 R 1245769 CDS LALA0_S01e03598g 34683498 336713..338248 Unknown 1 NW_019212879.1 similar to uniprot|C5DF18 Lachancea thermotolerans KLTH0D11528g hypothetical protein; uncharacterized protein 338248 34683498 LALA0_S01e03598g Lachancea lanzarotensis uncharacterized protein XP_022626370.1 336713 D 1245769 CDS LALA0_S01e03620g 34683499 complement(338352..340934) Unknown 1 NW_019212879.1 similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Putative protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study; non-specific serine/threonine protein kinase 340934 34683499 LALA0_S01e03620g Lachancea lanzarotensis non-specific serine/threonine protein kinase XP_022626371.1 338352 R 1245769 CDS LALA0_S01e03642g 34683500 342669..344150 Unknown 1 NW_019212879.1 similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; tetrahydrofolate synthase 344150 34683500 LALA0_S01e03642g Lachancea lanzarotensis tetrahydrofolate synthase XP_022626372.1 342669 D 1245769 CDS LALA0_S01e03664g 34683501 complement(344236..345468) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis; uncharacterized protein 345468 34683501 LALA0_S01e03664g Lachancea lanzarotensis uncharacterized protein XP_022626373.1 344236 R 1245769 CDS LALA0_S01e03686g 34683502 complement(345704..347791) Unknown 1 NW_019212879.1 similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria; uncharacterized protein 347791 34683502 LALA0_S01e03686g Lachancea lanzarotensis uncharacterized protein XP_022626374.1 345704 R 1245769 CDS LALA0_S01e03708g 34683503 347964..349280 Unknown 1 NW_019212879.1 similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; mRNA splicing protein PRP46 349280 34683503 LALA0_S01e03708g Lachancea lanzarotensis mRNA splicing protein PRP46 XP_022626375.1 347964 D 1245769 CDS LALA0_S01e03730g 34683504 350251..351600 Unknown 1 NW_019212879.1 highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus; NuA4 histone acetyltransferase complex catalytic subunit ESA1 351600 34683504 LALA0_S01e03730g Lachancea lanzarotensis NuA4 histone acetyltransferase complex catalytic subunit ESA1 XP_022626376.1 350251 D 1245769 CDS LALA0_S01e03752g 34683505 complement(351673..352734) Unknown 1 NW_019212879.1 similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; peptidylprolyl isomerase RRD2 352734 34683505 LALA0_S01e03752g Lachancea lanzarotensis peptidylprolyl isomerase RRD2 XP_022626377.1 351673 R 1245769 CDS LALA0_S01e03774g 34683506 complement(352934..354346) Unknown 1 NW_019212879.1 similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles; diacylglycerol O-acyltransferase 354346 34683506 LALA0_S01e03774g Lachancea lanzarotensis diacylglycerol O-acyltransferase XP_022626378.1 352934 R 1245769 CDS LALA0_S01e03796g 34683507 355560..357971 Unknown 1 NW_019212879.1 similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication; serine/threonine/tyrosine protein kinase RAD53 357971 34683507 LALA0_S01e03796g Lachancea lanzarotensis serine/threonine/tyrosine protein kinase RAD53 XP_022626379.1 355560 D 1245769 CDS LALA0_S01e03818g 34683508 358415..359671 Unknown 1 NW_019212879.1 highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates; proteinase A 359671 34683508 LALA0_S01e03818g Lachancea lanzarotensis proteinase A XP_022626380.1 358415 D 1245769 CDS LALA0_S01e03840g 34683509 360248..362158 Unknown 1 NW_019212879.1 similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle; uncharacterized protein 362158 34683509 LALA0_S01e03840g Lachancea lanzarotensis uncharacterized protein XP_022626381.1 360248 D 1245769 CDS LALA0_S01e03862g 34683510 363564..364403 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift; pheromone-regulated protein PRM4 364403 34683510 LALA0_S01e03862g Lachancea lanzarotensis pheromone-regulated protein PRM4 XP_022626382.1 363564 D 1245769 CDS LALA0_S01e03884g 34683511 complement(364593..365468) Unknown 1 NW_019212879.1 similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; RNA methyltransferase 365468 34683511 LALA0_S01e03884g Lachancea lanzarotensis RNA methyltransferase XP_022626383.1 364593 R 1245769 CDS LALA0_S01e03906g 34683512 366443..368185 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C AIM44 Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 368185 34683512 LALA0_S01e03906g Lachancea lanzarotensis uncharacterized protein XP_022626384.1 366443 D 1245769 CDS LALA0_S01e03928g 34683513 complement(368256..369590) Unknown 1 NW_019212879.1 similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; uncharacterized protein 369590 34683513 LALA0_S01e03928g Lachancea lanzarotensis uncharacterized protein XP_022626385.1 368256 R 1245769 CDS LALA0_S01e03950g 34683514 370850..371530 Unknown 1 NW_019212879.1 similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome; uncharacterized protein 371530 34683514 LALA0_S01e03950g Lachancea lanzarotensis uncharacterized protein XP_022626386.1 370850 D 1245769 CDS LALA0_S01e03972g 34683515 complement(371824..375114) Unknown 1 NW_019212879.1 highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA; leucine--tRNA ligase CDC60 375114 34683515 LALA0_S01e03972g Lachancea lanzarotensis leucine--tRNA ligase CDC60 XP_022626387.1 371824 R 1245769 CDS LALA0_S01e03994g 34683516 complement(375882..376853) Unknown 1 NW_019212879.1 similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 376853 34683516 LALA0_S01e03994g Lachancea lanzarotensis uncharacterized protein XP_022626388.1 375882 R 1245769 CDS LALA0_S01e04016g 34683517 377827..379608 Unknown 1 NW_019212879.1 similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length; uncharacterized protein 379608 34683517 LALA0_S01e04016g Lachancea lanzarotensis uncharacterized protein XP_022626389.1 377827 D 1245769 CDS LALA0_S01e04038g 34683518 379786..380646 Unknown 1 NW_019212879.1 similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology; uncharacterized protein 380646 34683518 LALA0_S01e04038g Lachancea lanzarotensis uncharacterized protein XP_022626390.1 379786 D 1245769 CDS LALA0_S01e04060g 34683519 381392..381997 Unknown 1 NW_019212879.1 similar to uniprot|C5DF63 Lachancea thermotolerans KLTH0D12540g hypothetical protein; uncharacterized protein 381997 34683519 LALA0_S01e04060g Lachancea lanzarotensis uncharacterized protein XP_022626391.1 381392 D 1245769 CDS LALA0_S01e04082g 34683520 382715..384571 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; mismatch repair protein MLH3 384571 34683520 LALA0_S01e04082g Lachancea lanzarotensis mismatch repair protein MLH3 XP_022626392.1 382715 D 1245769 CDS LALA0_S01e04104g 34683521 complement(384540..386459) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; anaphase promoting complex subunit 5 386459 34683521 LALA0_S01e04104g Lachancea lanzarotensis anaphase promoting complex subunit 5 XP_022626393.1 384540 R 1245769 CDS LALA0_S01e04126g 34683522 complement(388352..389713) Unknown 1 NW_019212879.1 similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; cleavage polyadenylation factor subunit CLP1 389713 34683522 LALA0_S01e04126g Lachancea lanzarotensis cleavage polyadenylation factor subunit CLP1 XP_022626394.1 388352 R 1245769 CDS LALA0_S01e04148g 34683523 complement(389868..390770) Unknown 1 NW_019212879.1 similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C TUM1 Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized; thiosulfate sulfurtransferase 390770 34683523 LALA0_S01e04148g Lachancea lanzarotensis thiosulfate sulfurtransferase XP_022626395.1 389868 R 1245769 CDS LALA0_S01e04170g 34683524 complement(392795..393346) Unknown 1 NW_019212879.1 similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W ATG29 Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; uncharacterized protein 393346 34683524 LALA0_S01e04170g Lachancea lanzarotensis uncharacterized protein XP_022626396.1 392795 R 1245769 CDS LALA0_S01e04192g 34683525 393480..397952 Unknown 1 NW_019212879.1 similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; DNA-directed DNA polymerase 397952 34683525 LALA0_S01e04192g Lachancea lanzarotensis DNA-directed DNA polymerase XP_022626397.1 393480 D 1245769 CDS LALA0_S01e04214g 34683526 398200..398766 Unknown 1 NW_019212879.1 similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W TMA16 Protein of unknown function that associates with ribosomes; uncharacterized protein 398766 34683526 LALA0_S01e04214g Lachancea lanzarotensis uncharacterized protein XP_022626398.1 398200 D 1245769 CDS LALA0_S01e04236g 34683527 complement(398790..400001) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12467 Saccharomyces cerevisiae YPL168W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated; uncharacterized protein 400001 34683527 LALA0_S01e04236g Lachancea lanzarotensis uncharacterized protein XP_022626399.1 398790 R 1245769 CDS LALA0_S01e04258g 34683528 400158..400649 Unknown 1 NW_019212879.1 similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; peptide alpha-N-acetyltransferase subunit NAT5 400649 34683528 LALA0_S01e04258g Lachancea lanzarotensis peptide alpha-N-acetyltransferase subunit NAT5 XP_022626400.1 400158 D 1245769 CDS LALA0_S01e04280g 34683529 complement(400769..402784) Unknown 1 NW_019212879.1 similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; protein-transporting protein SEC63 402784 34683529 LALA0_S01e04280g Lachancea lanzarotensis protein-transporting protein SEC63 XP_022626401.1 400769 R 1245769 CDS LALA0_S01e04302g 34683530 404525..406282 Unknown 1 NW_019212879.1 similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP; uncharacterized protein 406282 34683530 LALA0_S01e04302g Lachancea lanzarotensis uncharacterized protein XP_022626402.1 404525 D 1245769 CDS LALA0_S01e04324g 34683531 406610..407614 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p; uncharacterized protein 407614 34683531 LALA0_S01e04324g Lachancea lanzarotensis uncharacterized protein XP_022626403.1 406610 D 1245769 CDS LALA0_S01e04346g 34683532 complement(407672..408127) Unknown 1 NW_019212879.1 highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; uncharacterized protein 408127 34683532 LALA0_S01e04346g Lachancea lanzarotensis uncharacterized protein XP_022626404.1 407672 R 1245769 CDS LALA0_S01e04368g 34683533 complement(408459..410825) Unknown 1 NW_019212879.1 similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C (ohnolog of YOR256C) TRE1 Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors; uncharacterized protein 410825 34683533 LALA0_S01e04368g Lachancea lanzarotensis uncharacterized protein XP_022626405.1 408459 R 1245769 CDS LALA0_S01e04390g 34683534 join(412106..412122,412192..413491) Unknown 1 NW_019212879.1 similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins; phosphatidylinositol N-acetylglucosaminyltransferase SPT14 413491 34683534 LALA0_S01e04390g Lachancea lanzarotensis phosphatidylinositol N-acetylglucosaminyltransferase SPT14 XP_022626406.1 412106 D 1245769 CDS LALA0_S01e04412g 34683535 complement(413513..415942) Unknown 1 NW_019212879.1 weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued); uncharacterized protein 415942 34683535 LALA0_S01e04412g Lachancea lanzarotensis uncharacterized protein XP_022626407.1 413513 R 1245769 CDS LALA0_S01e04434g 34683536 416102..416632 Unknown 1 NW_019212879.1 highly similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation; centrin 416632 34683536 LALA0_S01e04434g Lachancea lanzarotensis centrin XP_022626408.1 416102 D 1245769 CDS LALA0_S01e04456g 34683537 417372..418253 Unknown 1 NW_019212879.1 similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL24m 418253 34683537 LALA0_S01e04456g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL24m XP_022626409.1 417372 D 1245769 CDS LALA0_S01e04478g 34683538 418422..419063 Unknown 1 NW_019212879.1 similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; DNA 5'-adenosine monophosphate hydrolase 419063 34683538 LALA0_S01e04478g Lachancea lanzarotensis DNA 5'-adenosine monophosphate hydrolase XP_022626410.1 418422 D 1245769 CDS LALA0_S01e04500g 34683539 complement(419086..420384) Unknown 1 NW_019212879.1 highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization; proteasome regulatory particle base subunit RPT4 420384 34683539 LALA0_S01e04500g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT4 XP_022626411.1 419086 R 1245769 CDS LALA0_S01e04522g 34683540 421354..422859 Unknown 1 NW_019212879.1 similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B subunit gamma 422859 34683540 LALA0_S01e04522g Lachancea lanzarotensis translation initiation factor eIF2B subunit gamma XP_022626412.1 421354 D 1245769 CDS LALA0_S01e04544g 34683541 complement(422917..424257) Unknown 1 NW_019212879.1 similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders; protoheme IX farnesyltransferase 424257 34683541 LALA0_S01e04544g Lachancea lanzarotensis protoheme IX farnesyltransferase XP_022626413.1 422917 R 1245769 CDS LALA0_S01e04566g 34683542 complement(425116..426150) Unknown 1 NW_019212879.1 highly similar to uniprot|Q08723 Saccharomyces cerevisiae YOR261C RPN8 Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; proteasome regulatory particle lid subunit RPN8 426150 34683542 LALA0_S01e04566g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN8 XP_022626414.1 425116 R 1245769 CDS LALA0_S01e04588g 34683543 427279..428322 Unknown 1 NW_019212879.1 highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B; uncharacterized protein 428322 34683543 LALA0_S01e04588g Lachancea lanzarotensis uncharacterized protein XP_022626415.1 427279 D 1245769 CDS LALA0_S01e04610g 34683544 428706..429941 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein, may help establish daughter fate; uncharacterized protein 429941 34683544 LALA0_S01e04610g Lachancea lanzarotensis uncharacterized protein XP_022626416.1 428706 D 1245769 CDS LALA0_S01e04632g 34683545 430285..430605 Unknown 1 NW_019212879.1 similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; uncharacterized protein 430605 34683545 LALA0_S01e04632g Lachancea lanzarotensis uncharacterized protein XP_022626417.1 430285 D 1245769 CDS LALA0_S01e04654g 34683546 431066..432277 Unknown 1 NW_019212879.1 similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine; uncharacterized protein 432277 34683546 LALA0_S01e04654g Lachancea lanzarotensis uncharacterized protein XP_022626418.1 431066 D 1245769 CDS LALA0_S01e04676g 34683547 complement(432401..434206) Unknown 1 NW_019212879.1 similar to uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; uncharacterized protein 434206 34683547 LALA0_S01e04676g Lachancea lanzarotensis uncharacterized protein XP_022626419.1 432401 R 1245769 CDS LALA0_S01e04698g 34683548 436131..437516 Unknown 1 NW_019212879.1 similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1; uncharacterized protein 437516 34683548 LALA0_S01e04698g Lachancea lanzarotensis uncharacterized protein XP_022626420.1 436131 D 1245769 CDS LALA0_S01e04720g 34683549 complement(437590..440031) Unknown 1 NW_019212879.1 similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; H(+)-transporting V0 sector ATPase subunit a 440031 34683549 LALA0_S01e04720g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit a XP_022626421.1 437590 R 1245769 CDS LALA0_S01e04742g 34683550 441430..442677 Unknown 1 NW_019212879.1 similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; mevalonate kinase 442677 34683550 LALA0_S01e04742g Lachancea lanzarotensis mevalonate kinase XP_022626422.1 441430 D 1245769 CDS LALA0_S01e04764g 34683551 complement(442811..443794) Unknown 1 NW_019212879.1 highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C FSF1 Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis; uncharacterized protein 443794 34683551 LALA0_S01e04764g Lachancea lanzarotensis uncharacterized protein XP_022626423.1 442811 R 1245769 CDS LALA0_S01e04808g 34683553 445337..446674 Unknown 1 NW_019212879.1 highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats; uncharacterized protein 446674 34683553 LALA0_S01e04808g Lachancea lanzarotensis uncharacterized protein XP_022626424.1 445337 D 1245769 CDS LALA0_S01e04830g 34683554 complement(446708..448003) Unknown 1 NW_019212879.1 similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene; uncharacterized protein 448003 34683554 LALA0_S01e04830g Lachancea lanzarotensis uncharacterized protein XP_022626425.1 446708 R 1245769 CDS LALA0_S01e04852g 34683555 complement(448190..449899) Unknown 1 NW_019212879.1 similar to uniprot|Q12256 Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily; uncharacterized protein 449899 34683555 LALA0_S01e04852g Lachancea lanzarotensis uncharacterized protein XP_022626426.1 448190 R 1245769 CDS LALA0_S01e04874g 34683556 complement(451790..452800) Unknown 1 NW_019212879.1 similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 452800 34683556 LALA0_S01e04874g Lachancea lanzarotensis uncharacterized protein XP_022626427.1 451790 R 1245769 CDS LALA0_S01e04896g 34683557 453776..455170 Unknown 1 NW_019212879.1 similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W DML1 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family; uncharacterized protein 455170 34683557 LALA0_S01e04896g Lachancea lanzarotensis uncharacterized protein XP_022626428.1 453776 D 1245769 CDS LALA0_S01e04918g 34683558 455286..456584 Unknown 1 NW_019212879.1 similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; tRNA dimethylallyltransferase 456584 34683558 LALA0_S01e04918g Lachancea lanzarotensis tRNA dimethylallyltransferase XP_022626429.1 455286 D 1245769 CDS LALA0_S01e04940g 34683559 complement(456612..458582) Unknown 1 NW_019212879.1 similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation; uncharacterized protein 458582 34683559 LALA0_S01e04940g Lachancea lanzarotensis uncharacterized protein XP_022626430.1 456612 R 1245769 CDS LALA0_S01e04962g 34683560 complement(458819..461020) Unknown 1 NW_019212879.1 similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene; uncharacterized protein 461020 34683560 LALA0_S01e04962g Lachancea lanzarotensis uncharacterized protein XP_022626431.1 458819 R 1245769 CDS LALA0_S01e04984g 34683561 461455..463056 Unknown 1 NW_019212879.1 similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; uncharacterized protein 463056 34683561 LALA0_S01e04984g Lachancea lanzarotensis uncharacterized protein XP_022626432.1 461455 D 1245769 CDS LALA0_S01e05006g 34683562 463657..464133 Unknown 1 NW_019212879.1 similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E; uncharacterized protein 464133 34683562 LALA0_S01e05006g Lachancea lanzarotensis uncharacterized protein XP_022626433.1 463657 D 1245769 CDS LALA0_S01e05028g 34683563 465657..466793 Unknown 1 NW_019212879.1 similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins; uncharacterized protein 466793 34683563 LALA0_S01e05028g Lachancea lanzarotensis uncharacterized protein XP_022626434.1 465657 D 1245769 CDS LALA0_S01e05050g 34683564 complement(468495..470270) Unknown 1 NW_019212879.1 similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C SKY1 SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1; serine/threonine protein kinase SKY1 470270 34683564 LALA0_S01e05050g Lachancea lanzarotensis serine/threonine protein kinase SKY1 XP_022626435.1 468495 R 1245769 CDS LALA0_S01e05072g 34683565 complement(join(470942..471920,472004..472083)) Unknown 1 NW_019212879.1 similar to uniprot|C5DCP7 Lachancea thermotolerans KLTH0B04796g hypothetical protein; uncharacterized protein 472083 34683565 LALA0_S01e05072g Lachancea lanzarotensis uncharacterized protein XP_022626436.1 470942 R 1245769 CDS LALA0_S01e05094g 34683566 472331..476815 Unknown 1 NW_019212879.1 similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; uncharacterized protein 476815 34683566 LALA0_S01e05094g Lachancea lanzarotensis uncharacterized protein XP_022626437.1 472331 D 1245769 CDS LALA0_S01e05116g 34683567 478214..479794 Unknown 1 NW_019212879.1 highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA; GMP synthase (glutamine-hydrolyzing) 479794 34683567 LALA0_S01e05116g Lachancea lanzarotensis GMP synthase (glutamine-hydrolyzing) XP_022626438.1 478214 D 1245769 CDS LALA0_S01e05138g 34683568 479924..480709 Unknown 1 NW_019212879.1 similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria; uroporphyrinogen-III synthase HEM4 480709 34683568 LALA0_S01e05138g Lachancea lanzarotensis uroporphyrinogen-III synthase HEM4 XP_022626439.1 479924 D 1245769 CDS LALA0_S01e05160g 34683569 complement(480735..484040) Unknown 1 NW_019212879.1 similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; transport protein particle complex II subunit TRS130 484040 34683569 LALA0_S01e05160g Lachancea lanzarotensis transport protein particle complex II subunit TRS130 XP_022626440.1 480735 R 1245769 CDS LALA0_S01e05182g 34683570 484210..488472 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p; uncharacterized protein 488472 34683570 LALA0_S01e05182g Lachancea lanzarotensis uncharacterized protein XP_022626441.1 484210 D 1245769 CDS LALA0_S01e05204g 34683571 488748..490088 Unknown 1 NW_019212879.1 similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; phosphomevalonate kinase 490088 34683571 LALA0_S01e05204g Lachancea lanzarotensis phosphomevalonate kinase XP_022626442.1 488748 D 1245769 CDS LALA0_S01e05226g 34683572 complement(490162..491145) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance; uncharacterized protein 491145 34683572 LALA0_S01e05226g Lachancea lanzarotensis uncharacterized protein XP_022626443.1 490162 R 1245769 CDS LALA0_S01e05248g 34683573 complement(491384..492997) Unknown 1 NW_019212879.1 similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy; uncharacterized protein 492997 34683573 LALA0_S01e05248g Lachancea lanzarotensis uncharacterized protein XP_022626444.1 491384 R 1245769 CDS LALA0_S01e05270g 34683574 complement(493551..494324) Unknown 1 NW_019212879.1 similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C (ohnolog of YMR222C) FSH3 Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2; uncharacterized protein 494324 34683574 LALA0_S01e05270g Lachancea lanzarotensis uncharacterized protein XP_022626445.1 493551 R 1245769 CDS LALA0_S01e05292g 34683575 complement(495233..496978) Unknown 1 NW_019212879.1 similar to uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage; uncharacterized protein 496978 34683575 LALA0_S01e05292g Lachancea lanzarotensis uncharacterized protein XP_022626446.1 495233 R 1245769 CDS LALA0_S01e05314g 34683576 498533..498802 Unknown 1 NW_019212879.1 highly similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A (ohnolog of YER087C-B SBH1) SBH2 Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p; uncharacterized protein 498802 34683576 LALA0_S01e05314g Lachancea lanzarotensis uncharacterized protein XP_022626447.1 498533 D 1245769 CDS LALA0_S01e05336g 34683577 complement(498975..500681) Unknown 1 NW_019212879.1 similar to uniprot|P39965 Saccharomyces cerevisiae YER087W AIM10 Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss; uncharacterized protein 500681 34683577 LALA0_S01e05336g Lachancea lanzarotensis uncharacterized protein XP_022626448.1 498975 R 1245769 CDS LALA0_S01e05358g 34683578 complement(500974..502659) Unknown 1 NW_019212879.1 highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; threonine ammonia-lyase ILV1 502659 34683578 LALA0_S01e05358g Lachancea lanzarotensis threonine ammonia-lyase ILV1 XP_022626449.1 500974 R 1245769 CDS LALA0_S01e05380g 34683579 503875..505395 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p; uncharacterized protein 505395 34683579 LALA0_S01e05380g Lachancea lanzarotensis uncharacterized protein XP_022626450.1 503875 D 1245769 CDS LALA0_S01e05424g 34683581 506465..507664 Unknown 1 NW_019212879.1 similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p; peroxin PEX13 507664 34683581 LALA0_S01e05424g Lachancea lanzarotensis peroxin PEX13 XP_022626451.1 506465 D 1245769 CDS LALA0_S01e05446g 34683582 complement(507968..508498) Unknown 1 NW_019212879.1 similar to uniprot|Q12491 Saccharomyces cerevisiae TY2B-B transposon Ty2-B Gag-Pol polyprotein; uncharacterized protein 508498 34683582 LALA0_S01e05446g Lachancea lanzarotensis uncharacterized protein XP_022626452.1 507968 R 1245769 CDS LALA0_S01e05490g 34683584 complement(510184..511860) Unknown 1 NW_019212879.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; D-lactate dehydrogenase 511860 34683584 LALA0_S01e05490g Lachancea lanzarotensis D-lactate dehydrogenase XP_022626453.1 510184 R 1245769 CDS LALA0_S01e05512g 34683585 complement(512681..513493) Unknown 1 NW_019212879.1 similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA; translation initiation factor eIF3 core subunit j 513493 34683585 LALA0_S01e05512g Lachancea lanzarotensis translation initiation factor eIF3 core subunit j XP_022626454.1 512681 R 1245769 CDS LALA0_S01e05534g 34683586 514359..514859 Unknown 1 NW_019212879.1 some similarities with uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W PAR32 Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene; uncharacterized protein 514859 34683586 LALA0_S01e05534g Lachancea lanzarotensis uncharacterized protein XP_022626455.1 514359 D 1245769 CDS LALA0_S01e05556g 34683587 complement(515129..521581) Unknown 1 NW_019212879.1 highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; glutamate synthase (NADH) 521581 34683587 LALA0_S01e05556g Lachancea lanzarotensis glutamate synthase (NADH) XP_022626456.1 515129 R 1245769 CDS LALA0_S01e05578g 34683588 complement(523660..525276) Unknown 1 NW_019212879.1 hypothetical protein; uncharacterized protein 525276 34683588 LALA0_S01e05578g Lachancea lanzarotensis uncharacterized protein XP_022626457.1 523660 R 1245769 CDS LALA0_S01e05600g 34683589 complement(525820..527934) Unknown 1 NW_019212879.1 similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis; RNA helicase 527934 34683589 LALA0_S01e05600g Lachancea lanzarotensis RNA helicase XP_022626458.1 525820 R 1245769 CDS LALA0_S01e05622g 34683590 528261..529013 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W RIM9 Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein; uncharacterized protein 529013 34683590 LALA0_S01e05622g Lachancea lanzarotensis uncharacterized protein XP_022626459.1 528261 D 1245769 CDS LALA0_S01e05644g 34683591 529184..530857 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase; uncharacterized protein 530857 34683591 LALA0_S01e05644g Lachancea lanzarotensis uncharacterized protein XP_022626460.1 529184 D 1245769 CDS LALA0_S01e05666g 34683592 531511..533019 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone; uncharacterized protein 533019 34683592 LALA0_S01e05666g Lachancea lanzarotensis uncharacterized protein XP_022626461.1 531511 D 1245769 CDS LALA0_S01e05688g 34683593 complement(533146..536091) Unknown 1 NW_019212879.1 highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes; 6-phosphofructokinase subunit alpha 536091 34683593 LALA0_S01e05688g Lachancea lanzarotensis 6-phosphofructokinase subunit alpha XP_022626462.1 533146 R 1245769 CDS LALA0_S01e05710g 34683594 complement(536893..538866) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38856 Saccharomyces cerevisiae YHR161C (ohnolog of YGR241C) YAP1801 Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family; uncharacterized protein 538866 34683594 LALA0_S01e05710g Lachancea lanzarotensis uncharacterized protein XP_022626463.1 536893 R 1245769 CDS LALA0_S01e05732g 34683595 complement(539083..539358) Unknown 1 NW_019212879.1 weakly similar to uniprot|C5DE44 Lachancea thermotolerans KLTH0C06160g hypothetical protein; uncharacterized protein 539358 34683595 LALA0_S01e05732g Lachancea lanzarotensis uncharacterized protein XP_022626464.1 539083 R 1245769 CDS LALA0_S01e05754g 34683596 543536..545182 Unknown 1 NW_019212879.1 highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; F1F0 ATP synthase subunit alpha 545182 34683596 LALA0_S01e05754g Lachancea lanzarotensis F1F0 ATP synthase subunit alpha XP_022626465.1 543536 D 1245769 CDS LALA0_S01e05776g 34683597 545758..546849 Unknown 1 NW_019212879.1 similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; TFIIH complex kinase subunit CCL1 546849 34683597 LALA0_S01e05776g Lachancea lanzarotensis TFIIH complex kinase subunit CCL1 XP_022626466.1 545758 D 1245769 CDS LALA0_S01e05798g 34683598 complement(547098..549284) Unknown 1 NW_019212879.1 highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover; i-AAA protease YME1 549284 34683598 LALA0_S01e05798g Lachancea lanzarotensis i-AAA protease YME1 XP_022626467.1 547098 R 1245769 CDS LALA0_S01e05820g 34683599 complement(549755..552160) Unknown 1 NW_019212879.1 similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission; condensin subunit BRN1 552160 34683599 LALA0_S01e05820g Lachancea lanzarotensis condensin subunit BRN1 XP_022626468.1 549755 R 1245769 CDS LALA0_S01e05842g 34683600 complement(552464..553852) Unknown 1 NW_019212879.1 similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease; kynurenine 3-monooxygenase 553852 34683600 LALA0_S01e05842g Lachancea lanzarotensis kynurenine 3-monooxygenase XP_022626469.1 552464 R 1245769 CDS LALA0_S01e05864g 34683601 complement(554763..556700) Unknown 1 NW_019212879.1 weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; uncharacterized protein 556700 34683601 LALA0_S01e05864g Lachancea lanzarotensis uncharacterized protein XP_022626470.1 554763 R 1245769 CDS LALA0_S01e05886g 34683602 560636..561355 Unknown 1 NW_019212879.1 similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 561355 34683602 LALA0_S01e05886g Lachancea lanzarotensis uncharacterized protein XP_022626471.1 560636 D 1245769 CDS LALA0_S01e05908g 34683603 561616..563025 Unknown 1 NW_019212879.1 similar to uniprot|P38682 Saccharomyces cerevisiae YER122C GLO3 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p; ADP-ribosylation factor GTPase-activating protein 563025 34683603 LALA0_S01e05908g Lachancea lanzarotensis ADP-ribosylation factor GTPase-activating protein XP_022626472.1 561616 D 1245769 CDS LALA0_S01e05930g 34683604 complement(563265..563879) Unknown 1 NW_019212879.1 similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; uncharacterized protein 563879 34683604 LALA0_S01e05930g Lachancea lanzarotensis uncharacterized protein XP_022626473.1 563265 R 1245769 CDS LALA0_S01e05952g 34683605 565358..565753 Unknown 1 NW_019212879.1 highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing; 60S ribosomal protein eL32 565753 34683605 LALA0_S01e05952g Lachancea lanzarotensis 60S ribosomal protein eL32 XP_022626474.1 565358 D 1245769 CDS LALA0_S01e05974g 34683606 complement(join(566086..566774,567114..567150)) Unknown 1 NW_019212879.1 similar to uniprot|P40075 Saccharomyces cerevisiae YER120W (ohnolog of YBL091C-A) SCS2 Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog; phospholipid metabolism-regulating protein SCS22 567150 34683606 LALA0_S01e05974g Lachancea lanzarotensis phospholipid metabolism-regulating protein SCS22 XP_022626475.1 566086 R 1245769 CDS LALA0_S01e05996g 34683607 complement(567495..568772) Unknown 1 NW_019212879.1 highly similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; methionine aminopeptidase 568772 34683607 LALA0_S01e05996g Lachancea lanzarotensis methionine aminopeptidase XP_022626476.1 567495 R 1245769 CDS LALA0_S01e06018g 34683608 568956..569459 Unknown 1 NW_019212879.1 weakly similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; mitochondrial 37S ribosomal protein bS21m 569459 34683608 LALA0_S01e06018g Lachancea lanzarotensis mitochondrial 37S ribosomal protein bS21m XP_022626477.1 568956 D 1245769 CDS LALA0_S01e06040g 34683609 570518..571870 Unknown 1 NW_019212879.1 similar to uniprot|P40074 Saccharomyces cerevisiae YER119C (ohnolog of YBL089W) AVT6 Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; amino acid transporter 571870 34683609 LALA0_S01e06040g Lachancea lanzarotensis amino acid transporter XP_022626478.1 570518 D 1245769 CDS LALA0_S01e06062g 34683610 572312..573340 Unknown 1 NW_019212879.1 similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p; osmosensor SHO1 573340 34683610 LALA0_S01e06062g Lachancea lanzarotensis osmosensor SHO1 XP_022626479.1 572312 D 1245769 CDS LALA0_S01e06084g 34683611 complement(573443..581761) Unknown 1 NW_019212879.1 similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene; DNA-binding protein kinase TEL1 581761 34683611 LALA0_S01e06084g Lachancea lanzarotensis DNA-binding protein kinase TEL1 XP_022626480.1 573443 R 1245769 CDS LALA0_S01e06106g 34683612 complement(join(582576..582947,583272..583313)) Unknown 1 NW_019212879.1 highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W (ohnolog of YBL087C) RPL23B Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins; 60S ribosomal protein uL14 583313 34683612 LALA0_S01e06106g Lachancea lanzarotensis 60S ribosomal protein uL14 XP_022626481.1 582576 R 1245769 CDS LALA0_S01e06128g 34683613 585426..586139 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; SUMO-targeted ubiquitin ligase complex subunit SLX8 586139 34683613 LALA0_S01e06128g Lachancea lanzarotensis SUMO-targeted ubiquitin ligase complex subunit SLX8 XP_022626482.1 585426 D 1245769 CDS LALA0_S01e06150g 34683614 586304..586621 Unknown 1 NW_019212879.1 some similarities with uniprot|Q01684 Saccharomyces cerevisiae YER115C SPR6 Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation; uncharacterized protein 586621 34683614 LALA0_S01e06150g Lachancea lanzarotensis uncharacterized protein XP_022626483.1 586304 D 1245769 CDS LALA0_S01e06172g 34683615 complement(586808..588055) Unknown 1 NW_019212879.1 similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 588055 34683615 LALA0_S01e06172g Lachancea lanzarotensis uncharacterized protein XP_022626484.1 586808 R 1245769 CDS LALA0_S01e06194g 34683616 589934..590926 Unknown 1 NW_019212879.1 similar to uniprot|C5DE44 Lachancea thermotolerans KLTH0C06160g hypothetical protein; uncharacterized protein 590926 34683616 LALA0_S01e06194g Lachancea lanzarotensis uncharacterized protein XP_022626485.1 589934 D 1245769 CDS LALA0_S01e06216g 34683617 592487..595576 Unknown 1 NW_019212879.1 similar to uniprot|P39969 Saccharomyces cerevisiae YER114C (ohnolog of YBL085W) BOI2 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; uncharacterized protein 595576 34683617 LALA0_S01e06216g Lachancea lanzarotensis uncharacterized protein XP_022626486.1 592487 D 1245769 CDS LALA0_S01e06238g 34683618 complement(596052..597980) Unknown 1 NW_019212879.1 similar to uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; anaphase promoting complex subunit CDC27 597980 34683618 LALA0_S01e06238g Lachancea lanzarotensis anaphase promoting complex subunit CDC27 XP_022626487.1 596052 R 1245769 CDS LALA0_S01e06260g 34683619 599154..601238 Unknown 1 NW_019212879.1 similar to uniprot|P40071 Saccharomyces cerevisiae YER113C TMN3 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation; uncharacterized protein 601238 34683619 LALA0_S01e06260g Lachancea lanzarotensis uncharacterized protein XP_022626488.1 599154 D 1245769 CDS LALA0_S01e06282g 34683620 complement(601358..601921) Unknown 1 NW_019212879.1 similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; U6 snRNA complex subunit LSM4 601921 34683620 LALA0_S01e06282g Lachancea lanzarotensis U6 snRNA complex subunit LSM4 XP_022626489.1 601358 R 1245769 CDS LALA0_S01e06304g 34683621 603463..606183 Unknown 1 NW_019212879.1 weakly similar to uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; SBF complex DNA-binding subunit SWI4 606183 34683621 LALA0_S01e06304g Lachancea lanzarotensis SBF complex DNA-binding subunit SWI4 XP_022626490.1 603463 D 1245769 CDS LALA0_S01e06326g 34683622 606652..609987 Unknown 1 NW_019212879.1 highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1; uncharacterized protein 609987 34683622 LALA0_S01e06326g Lachancea lanzarotensis uncharacterized protein XP_022626491.1 606652 D 1245769 CDS LALA0_S01e06348g 34683623 610241..611629 Unknown 1 NW_019212879.1 similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C ALG3 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase 611629 34683623 LALA0_S01e06348g Lachancea lanzarotensis dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase XP_022626492.1 610241 D 1245769 CDS LALA0_S01e06370g 34683624 612489..615386 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40068 Saccharomyces cerevisiae YER109C FLO8 Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene; uncharacterized protein 615386 34683624 LALA0_S01e06370g Lachancea lanzarotensis uncharacterized protein XP_022626493.1 612489 D 1245769 CDS LALA0_S01e06392g 34683625 615702..616805 Unknown 1 NW_019212879.1 highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p; RNA export factor GLE2 616805 34683625 LALA0_S01e06392g Lachancea lanzarotensis RNA export factor GLE2 XP_022626494.1 615702 D 1245769 CDS LALA0_S01e06414g 34683626 618179..619261 Unknown 1 NW_019212879.1 weakly similar to uniprot|P38180 Saccharomyces cerevisiae YBL081W Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport; uncharacterized protein 619261 34683626 LALA0_S01e06414g Lachancea lanzarotensis uncharacterized protein XP_022626495.1 618179 D 1245769 CDS LALA0_S01e06436g 34683627 complement(619679..621286) Unknown 1 NW_019212879.1 similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; glutamyl-tRNA(Gln) amidotransferase subunit PET112 621286 34683627 LALA0_S01e06436g Lachancea lanzarotensis glutamyl-tRNA(Gln) amidotransferase subunit PET112 XP_022626496.1 619679 R 1245769 CDS LALA0_S01e06458g 34683628 complement(621880..622755) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle; uncharacterized protein 622755 34683628 LALA0_S01e06458g Lachancea lanzarotensis uncharacterized protein XP_022626497.1 621880 R 1245769 CDS LALA0_S01e06480g 34683629 623914..628281 Unknown 1 NW_019212879.1 similar to uniprot|P40064 Saccharomyces cerevisiae YER105C (ohnolog of YBL079W) NUP157 Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly; uncharacterized protein 628281 34683629 LALA0_S01e06480g Lachancea lanzarotensis uncharacterized protein XP_022626498.1 623914 D 1245769 CDS LALA0_S01e06502g 34683630 complement(628846..629205) Unknown 1 NW_019212879.1 highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; ubiquitin-like protein ATG8 629205 34683630 LALA0_S01e06502g Lachancea lanzarotensis ubiquitin-like protein ATG8 XP_022626499.1 628846 R 1245769 CDS LALA0_S01e06524g 34683631 complement(629887..630474) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 Protein with a role in regulation of Ty1 transposition; uncharacterized protein 630474 34683631 LALA0_S01e06524g Lachancea lanzarotensis uncharacterized protein XP_022626500.1 629887 R 1245769 CDS LALA0_S01e06546g 34683632 complement(630702..633923) Unknown 1 NW_019212879.1 highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A; isoleucine--tRNA ligase ILS1 633923 34683632 LALA0_S01e06546g Lachancea lanzarotensis isoleucine--tRNA ligase ILS1 XP_022626501.1 630702 R 1245769 CDS LALA0_S01e06568g 34683633 complement(634511..636463) Unknown 1 NW_019212879.1 highly similar to uniprot|P22202 Saccharomyces cerevisiae YER103W (ohnolog of YBL075C) SSA4 Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; Hsp70 family ATPase SSA3 636463 34683633 LALA0_S01e06568g Lachancea lanzarotensis Hsp70 family ATPase SSA3 XP_022626502.1 634511 R 1245769 CDS LALA0_S01e06590g 34683634 complement(637379..638479) Unknown 1 NW_019212879.1 similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron; U5 snRNP complex subunit AAR2 638479 34683634 LALA0_S01e06590g Lachancea lanzarotensis U5 snRNP complex subunit AAR2 XP_022626503.1 637379 R 1245769 CDS LALA0_S01e06612g 34683635 complement(639305..639913) Unknown 1 NW_019212879.1 highly similar to uniprot|P05754 Saccharomyces cerevisiae YER102W (ohnolog of YBL072C) RPS8B Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein; 40S ribosomal protein eS8 639913 34683635 LALA0_S01e06612g Lachancea lanzarotensis 40S ribosomal protein eS8 XP_022626504.1 639305 R 1245769 CDS LALA0_S01e06634g 34683636 641130..641378 Unknown 1 NW_019212879.1 highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs; uncharacterized protein 641378 34683636 LALA0_S01e06634g Lachancea lanzarotensis uncharacterized protein XP_022626505.1 641130 D 1245769 CDS LALA0_S01e06656g 34683637 641837..643120 Unknown 1 NW_019212879.1 similar to uniprot|P39945 Saccharomyces cerevisiae YER101C (ohnolog of YBL069W) AST2 Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions; uncharacterized protein 643120 34683637 LALA0_S01e06656g Lachancea lanzarotensis uncharacterized protein XP_022626506.1 641837 D 1245769 CDS LALA0_S01e06678g 34683638 complement(643291..644028) Unknown 1 NW_019212879.1 similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; E2 ubiquitin-conjugating protein UBC6 644028 34683638 LALA0_S01e06678g Lachancea lanzarotensis E2 ubiquitin-conjugating protein UBC6 XP_022626507.1 643291 R 1245769 CDS LALA0_S01e06700g 34683639 645492..646448 Unknown 1 NW_019212879.1 highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C (ohnolog of YBL068W) PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; uncharacterized protein 646448 34683639 LALA0_S01e06700g Lachancea lanzarotensis uncharacterized protein XP_022626508.1 645492 D 1245769 CDS LALA0_S01e06722g 34683640 complement(646558..648708) Unknown 1 NW_019212879.1 similar to uniprot|P39967 Saccharomyces cerevisiae YER098W (ohnolog of YBL067C) UBP9 Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions; uncharacterized protein 648708 34683640 LALA0_S01e06722g Lachancea lanzarotensis uncharacterized protein XP_022626509.1 646558 R 1245769 CDS LALA0_S01e06766g 34683642 complement(649986..653126) Unknown 1 NW_019212879.1 similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Putative transcription factor, has homolog in Kluyveromyces lactis; uncharacterized protein 653126 34683642 LALA0_S01e06766g Lachancea lanzarotensis uncharacterized protein XP_022626510.1 649986 R 1245769 CDS LALA0_S01e06788g 34683643 complement(653637..654383) Unknown 1 NW_019212879.1 similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; thioredoxin peroxidase PRX1 654383 34683643 LALA0_S01e06788g Lachancea lanzarotensis thioredoxin peroxidase PRX1 XP_022626511.1 653637 R 1245769 CDS LALA0_S01e06810g 34683644 complement(655091..656992) Unknown 1 NW_019212879.1 similar to uniprot|P39000 Saccharomyces cerevisiae YER096W (ohnolog of YBL061C) SHC1 Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH; uncharacterized protein 656992 34683644 LALA0_S01e06810g Lachancea lanzarotensis uncharacterized protein XP_022626512.1 655091 R 1245769 CDS LALA0_S01e06832g 34683645 complement(657446..658621) Unknown 1 NW_019212879.1 highly similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; recombinase RAD51 658621 34683645 LALA0_S01e06832g Lachancea lanzarotensis recombinase RAD51 XP_022626513.1 657446 R 1245769 CDS LALA0_S01e06854g 34683646 659436..661340 Unknown 1 NW_019212879.1 weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W YEL1 Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip; Arf family guanine nucleotide exchange factor YEL1 661340 34683646 LALA0_S01e06854g Lachancea lanzarotensis Arf family guanine nucleotide exchange factor YEL1 XP_022626514.1 659436 D 1245769 CDS LALA0_S01e06876g 34683647 join(661683..661707,661877..662469) Unknown 1 NW_019212879.1 highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10; proteasome core particle subunit beta 3 662469 34683647 LALA0_S01e06876g Lachancea lanzarotensis proteasome core particle subunit beta 3 XP_022626515.1 661683 D 1245769 CDS LALA0_S01e06898g 34683648 complement(join(662641..662930,662998..663031)) Unknown 1 NW_019212879.1 similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059C-A CMC2 Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold; uncharacterized protein 663031 34683648 LALA0_S01e06898g Lachancea lanzarotensis uncharacterized protein XP_022626516.1 662641 R 1245769 CDS LALA0_S01e06920g 34683649 join(663746..663902,663962..664254) Unknown 1 NW_019212879.1 similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A (ohnolog of YBL059W) AIM11 Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; uncharacterized protein 664254 34683649 LALA0_S01e06920g Lachancea lanzarotensis uncharacterized protein XP_022626517.1 663746 D 1245769 CDS LALA0_S01e06942g 34683650 664458..668486 Unknown 1 NW_019212879.1 similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; TORC2 complex subunit TSC11 668486 34683650 LALA0_S01e06942g Lachancea lanzarotensis TORC2 complex subunit TSC11 XP_022626518.1 664458 D 1245769 CDS LALA0_S01e06964g 34683651 complement(668571..668912) Unknown 1 NW_019212879.1 similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; uncharacterized protein 668912 34683651 LALA0_S01e06964g Lachancea lanzarotensis uncharacterized protein XP_022626519.1 668571 R 1245769 CDS LALA0_S01e06986g 34683652 670590..672893 Unknown 1 NW_019212879.1 highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs; 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 672893 34683652 LALA0_S01e06986g Lachancea lanzarotensis 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase XP_022626520.1 670590 D 1245769 CDS LALA0_S01e07008g 34683653 join(673438..673530,673600..674646) Unknown 1 NW_019212879.1 similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; protein phosphatase regulator SHP1 674646 34683653 LALA0_S01e07008g Lachancea lanzarotensis protein phosphatase regulator SHP1 XP_022626521.1 673438 D 1245769 CDS LALA0_S01e07030g 34683654 complement(674838..675494) Unknown 1 NW_019212879.1 similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; aminoacyl-tRNA hydrolase 675494 34683654 LALA0_S01e07030g Lachancea lanzarotensis aminoacyl-tRNA hydrolase XP_022626522.1 674838 R 1245769 CDS LALA0_S01e07052g 34683655 complement(675661..677181) Unknown 1 NW_019212879.1 highly similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p; anthranilate synthase TRP2 677181 34683655 LALA0_S01e07052g Lachancea lanzarotensis anthranilate synthase TRP2 XP_022626523.1 675661 R 1245769 CDS LALA0_S01e07074g 34683656 join(678095..678151,678360..678608) Unknown 1 NW_019212879.1 highly similar to uniprot|Q06405 Saccharomyces cerevisiae YDR377W ATP17 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit f 678608 34683656 LALA0_S01e07074g Lachancea lanzarotensis F1F0 ATP synthase subunit f XP_022626524.1 678095 D 1245769 CDS LALA0_S01e07096g 34683657 complement(678804..679055) Unknown 1 NW_019212879.1 similar to uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; U4/U6-U5 snRNP complex subunit LSM6 679055 34683657 LALA0_S01e07096g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit LSM6 XP_022626525.1 678804 R 1245769 CDS LALA0_S01e07118g 34683658 680141..683035 Unknown 1 NW_019212879.1 similar to uniprot|Q06407 Saccharomyces cerevisiae YDR379W (ohnolog of YOR127W) RGA2 GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; GTPase-activating protein RGA2 683035 34683658 LALA0_S01e07118g Lachancea lanzarotensis GTPase-activating protein RGA2 XP_022626526.1 680141 D 1245769 CDS LALA0_S01e07140g 34683659 complement(683132..683371) Unknown 1 NW_019212879.1 highly similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy; uncharacterized protein 683371 34683659 LALA0_S01e07140g Lachancea lanzarotensis uncharacterized protein XP_022626527.1 683132 R 1245769 CDS LALA0_S01e07162g 34683660 684448..686058 Unknown 1 NW_019212879.1 similar to uniprot|C5DJD5 Lachancea thermotolerans KLTH0F15554g hypothetical protein; uncharacterized protein 686058 34683660 LALA0_S01e07162g Lachancea lanzarotensis uncharacterized protein XP_022626528.1 684448 D 1245769 CDS LALA0_S01e07184g 34683661 686738..689368 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32862 Saccharomyces cerevisiae YKL038W (ohnolog of YBR033W EDS1) RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; uncharacterized protein 689368 34683661 LALA0_S01e07184g Lachancea lanzarotensis uncharacterized protein XP_022626529.1 686738 D 1245769 CDS LALA0_S01e07206g 34683662 complement(690802..692523) Unknown 1 NW_019212879.1 highly similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine; phosphoribosylaminoimidazole carboxylase ADE2 692523 34683662 LALA0_S01e07206g Lachancea lanzarotensis phosphoribosylaminoimidazole carboxylase ADE2 XP_022626530.1 690802 R 1245769 CDS LALA0_S01e07228g 34683663 694132..696036 Unknown 1 NW_019212879.1 similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; phenylpyruvate decarboxylase ARO10 696036 34683663 LALA0_S01e07228g Lachancea lanzarotensis phenylpyruvate decarboxylase ARO10 XP_022626531.1 694132 D 1245769 CDS LALA0_S01e07250g 34683664 complement(696152..698821) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C AFI1 Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p; uncharacterized protein 698821 34683664 LALA0_S01e07250g Lachancea lanzarotensis uncharacterized protein XP_022626532.1 696152 R 1245769 CDS LALA0_S01e07272g 34683665 join(699976..700227,701072..701473) Unknown 1 NW_019212879.1 similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member; RNA-binding protein YRA1 701473 34683665 LALA0_S01e07272g Lachancea lanzarotensis RNA-binding protein YRA1 XP_022626533.1 699976 D 1245769 CDS LALA0_S01e07294g 34683666 complement(join(701682..701964,702023..702057)) Unknown 1 NW_019212879.1 similar to uniprot|Q3E6R5 Saccharomyces cerevisiae YDR381C-A Protein of unknown function, localized to the mitochondrial outer membrane; uncharacterized protein 702057 34683666 LALA0_S01e07294g Lachancea lanzarotensis uncharacterized protein XP_022626534.1 701682 R 1245769 CDS LALA0_S01e07316g 34683667 702613..703590 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W (ohnolog of YEL006W) YIA6 Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; uncharacterized protein 703590 34683667 LALA0_S01e07316g Lachancea lanzarotensis uncharacterized protein XP_022626535.1 702613 D 1245769 CDS LALA0_S01e07338g 34683668 complement(703654..704502) Unknown 1 NW_019212879.1 similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome; uncharacterized protein 704502 34683668 LALA0_S01e07338g Lachancea lanzarotensis uncharacterized protein XP_022626536.1 703654 R 1245769 CDS LALA0_S01e07360g 34683669 705309..705644 Unknown 1 NW_019212879.1 highly similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; ribosomal protein P2 705644 34683669 LALA0_S01e07360g Lachancea lanzarotensis ribosomal protein P2 XP_022626537.1 705309 D 1245769 CDS LALA0_S01e07382g 34683670 complement(705806..706516) Unknown 1 NW_019212879.1 similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C NKP1 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p); uncharacterized protein 706516 34683670 LALA0_S01e07382g Lachancea lanzarotensis uncharacterized protein XP_022626538.1 705806 R 1245769 CDS LALA0_S01e07426g 34683672 complement(706956..707831) Unknown 1 NW_019212879.1 similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters; uncharacterized protein 707831 34683672 LALA0_S01e07426g Lachancea lanzarotensis uncharacterized protein XP_022626539.1 706956 R 1245769 CDS LALA0_S01e07448g 34683673 complement(join(710458..711032,711099..711207)) Unknown 1 NW_019212879.1 similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest; uncharacterized protein 711207 34683673 LALA0_S01e07448g Lachancea lanzarotensis uncharacterized protein XP_022626540.1 710458 R 1245769 CDS LALA0_S01e07470g 34683674 711404..712990 Unknown 1 NW_019212879.1 similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; retromer subunit VPS17 712990 34683674 LALA0_S01e07470g Lachancea lanzarotensis retromer subunit VPS17 XP_022626541.1 711404 D 1245769 CDS LALA0_S01e07492g 34683675 713945..716473 Unknown 1 NW_019212879.1 highly similar to uniprot|P32324 Saccharomyces cerevisiae YDR385W (ohnolog of YOR133W) EFT2 Elongationfactor 2 (EF-2), also encoded by EFT1; catalyzes ribosomaltranslocation during protein synthesis; containsdiphthamide, the unique posttranslationally modifiedhistidine residue specifically ADP-ribosylated bydiphtheria toxin; uncharacterized protein 716473 34683675 LALA0_S01e07492g Lachancea lanzarotensis uncharacterized protein XP_022626542.1 713945 D 1245769 CDS LALA0_S01e07514g 34683676 716831..718687 Unknown 1 NW_019212879.1 similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; uncharacterized protein 718687 34683676 LALA0_S01e07514g Lachancea lanzarotensis uncharacterized protein XP_022626543.1 716831 D 1245769 CDS LALA0_S01e07536g 34683677 complement(718708..720303) Unknown 1 NW_019212879.1 similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Putative transporter, member of the sugar porter family; YDR387C is not an essential gene; uncharacterized protein 720303 34683677 LALA0_S01e07536g Lachancea lanzarotensis uncharacterized protein XP_022626544.1 718708 R 1245769 CDS LALA0_S01e07558g 34683678 722237..723520 Unknown 1 NW_019212879.1 similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; amphiphysin 723520 34683678 LALA0_S01e07558g Lachancea lanzarotensis amphiphysin XP_022626545.1 722237 D 1245769 CDS LALA0_S01e07580g 34683679 723808..725649 Unknown 1 NW_019212879.1 similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W (ohnolog of YOR134W) SAC7 GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate; uncharacterized protein 725649 34683679 LALA0_S01e07580g Lachancea lanzarotensis uncharacterized protein XP_022626546.1 723808 D 1245769 CDS LALA0_S01e07602g 34683680 complement(725714..727534) Unknown 1 NW_019212879.1 similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; E1 ubiquitin-activating protein UBA2 727534 34683680 LALA0_S01e07602g Lachancea lanzarotensis E1 ubiquitin-activating protein UBA2 XP_022626547.1 725714 R 1245769 CDS LALA0_S01e07624g 34683681 729214..730320 Unknown 1 NW_019212879.1 highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; isocitrate dehydrogenase (NAD(+)) IDH2 730320 34683681 LALA0_S01e07624g Lachancea lanzarotensis isocitrate dehydrogenase (NAD(+)) IDH2 XP_022626548.1 729214 D 1245769 CDS LALA0_S01e07646g 34683682 complement(732357..734147) Unknown 1 NW_019212879.1 similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1 Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; uncharacterized protein 734147 34683682 LALA0_S01e07646g Lachancea lanzarotensis uncharacterized protein XP_022626549.1 732357 R 1245769 CDS LALA0_S01e07668g 34683683 736720..739032 Unknown 1 NW_019212879.1 weakly similar to uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; uncharacterized protein 739032 34683683 LALA0_S01e07668g Lachancea lanzarotensis uncharacterized protein XP_022626550.1 736720 D 1245769 CDS LALA0_S01e07690g 34683684 complement(739224..741602) Unknown 1 NW_019212879.1 similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity; uncharacterized protein 741602 34683684 LALA0_S01e07690g Lachancea lanzarotensis uncharacterized protein XP_022626551.1 739224 R 1245769 CDS LALA0_S01e07712g 34683685 742064..742708 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c; uncharacterized protein 742708 34683685 LALA0_S01e07712g Lachancea lanzarotensis uncharacterized protein XP_022626552.1 742064 D 1245769 CDS LALA0_S01e07734g 34683686 complement(744380..744790) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes; uncharacterized protein 744790 34683686 LALA0_S01e07734g Lachancea lanzarotensis uncharacterized protein XP_022626553.1 744380 R 1245769 CDS LALA0_S01e07756g 34683687 complement(744946..745440) Unknown 1 NW_019212879.1 similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis; E2 ubiquitin-protein ligase peroxin 4 745440 34683687 LALA0_S01e07756g Lachancea lanzarotensis E2 ubiquitin-protein ligase peroxin 4 XP_022626554.1 744946 R 1245769 CDS LALA0_S01e07778g 34683688 746192..747037 Unknown 1 NW_019212879.1 highly similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C PHB1 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin subunit PHB1 747037 34683688 LALA0_S01e07778g Lachancea lanzarotensis prohibitin subunit PHB1 XP_022626555.1 746192 D 1245769 CDS LALA0_S01e07800g 34683689 complement(747732..748244) Unknown 1 NW_019212879.1 similar to uniprot|P53279 Saccharomyces cerevisiae YGR131W (ohnolog of YPR149W) FHN1 Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; uncharacterized protein 748244 34683689 LALA0_S01e07800g Lachancea lanzarotensis uncharacterized protein XP_022626556.1 747732 R 1245769 CDS LALA0_S01e07822g 34683690 750006..752381 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7); uncharacterized protein 752381 34683690 LALA0_S01e07822g Lachancea lanzarotensis uncharacterized protein XP_022626557.1 750006 D 1245769 CDS LALA0_S01e07844g 34683691 752728..753834 Unknown 1 NW_019212879.1 similar to uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 753834 34683691 LALA0_S01e07844g Lachancea lanzarotensis uncharacterized protein XP_022626558.1 752728 D 1245769 CDS LALA0_S01e07866g 34683692 complement(753839..754477) Unknown 1 NW_019212879.1 similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest; uncharacterized protein 754477 34683692 LALA0_S01e07866g Lachancea lanzarotensis uncharacterized protein XP_022626559.1 753839 R 1245769 CDS LALA0_S01e07888g 34683693 754772..756712 Unknown 1 NW_019212879.1 similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 756712 34683693 LALA0_S01e07888g Lachancea lanzarotensis uncharacterized protein XP_022626560.1 754772 D 1245769 CDS LALA0_S01e07910g 34683694 756902..757813 Unknown 1 NW_019212879.1 similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; bifunctional triacylglycerol lipase/ester hydrolase 757813 34683694 LALA0_S01e07910g Lachancea lanzarotensis bifunctional triacylglycerol lipase/ester hydrolase XP_022626561.1 756902 D 1245769 CDS LALA0_S01e07932g 34683695 complement(758320..759012) Unknown 1 NW_019212879.1 weakly similar to uniprot|P53274 Saccharomyces cerevisiae YGR126W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; uncharacterized protein 759012 34683695 LALA0_S01e07932g Lachancea lanzarotensis uncharacterized protein XP_022626562.1 758320 R 1245769 CDS LALA0_S01e07954g 34683696 complement(759510..762632) Unknown 1 NW_019212879.1 similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; uncharacterized protein 762632 34683696 LALA0_S01e07954g Lachancea lanzarotensis uncharacterized protein XP_022626563.1 759510 R 1245769 CDS LALA0_S01e07976g 34683697 764708..765169 Unknown 1 NW_019212879.1 hypothetical protein; uncharacterized protein 765169 34683697 LALA0_S01e07976g Lachancea lanzarotensis uncharacterized protein XP_022626564.1 764708 D 1245769 CDS LALA0_S01e07998g 34683698 complement(765363..767081) Unknown 1 NW_019212879.1 highly similar to uniprot|P49090 Saccharomyces cerevisiae YGR124W (ohnolog of YPR145W) ASN2 Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; uncharacterized protein 767081 34683698 LALA0_S01e07998g Lachancea lanzarotensis uncharacterized protein XP_022626565.1 765363 R 1245769 CDS LALA0_S01e08020g 34683699 768746..770350 Unknown 1 NW_019212879.1 similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; ribosome biosynthesis protein NOC4 770350 34683699 LALA0_S01e08020g Lachancea lanzarotensis ribosome biosynthesis protein NOC4 XP_022626566.1 768746 D 1245769 CDS LALA0_S01e08064g 34683701 771549..773087 Unknown 1 NW_019212879.1 highly similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C PPT1 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing; protein serine/threonine phosphatase 773087 34683701 LALA0_S01e08064g Lachancea lanzarotensis protein serine/threonine phosphatase XP_022626567.1 771549 D 1245769 CDS LALA0_S01e08086g 34683702 complement(773305..774129) Unknown 1 NW_019212879.1 similar to uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs; uncharacterized protein 774129 34683702 LALA0_S01e08086g Lachancea lanzarotensis uncharacterized protein XP_022626568.1 773305 R 1245769 CDS LALA0_S01e08108g 34683703 775566..777734 Unknown 1 NW_019212879.1 similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; uncharacterized protein 777734 34683703 LALA0_S01e08108g Lachancea lanzarotensis uncharacterized protein XP_022626569.1 775566 D 1245769 CDS LALA0_S01e08130g 34683704 complement(777799..779007) Unknown 1 NW_019212879.1 similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W TAZ1 Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome; lysophosphatidylcholine acyltransferase 779007 34683704 LALA0_S01e08130g Lachancea lanzarotensis lysophosphatidylcholine acyltransferase XP_022626570.1 777799 R 1245769 CDS LALA0_S01e08152g 34683705 779675..780616 Unknown 1 NW_019212879.1 similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66 Cytoplasmic protein of unknown function involved in vacuolar protein sorting; lysophosphatidic acid acyltransferase LOA1 780616 34683705 LALA0_S01e08152g Lachancea lanzarotensis lysophosphatidic acid acyltransferase LOA1 XP_022626571.1 779675 D 1245769 CDS LALA0_S01e08174g 34683706 complement(780648..781844) Unknown 1 NW_019212879.1 weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; uncharacterized protein 781844 34683706 LALA0_S01e08174g Lachancea lanzarotensis uncharacterized protein XP_022626572.1 780648 R 1245769 CDS LALA0_S01e08196g 34683707 783227..784588 Unknown 1 NW_019212879.1 highly similar to uniprot|P40260 Saccharomyces cerevisiae YGR121C (ohnolog of YPR138C) MEP1 Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; ammonium permease MEP3 784588 34683707 LALA0_S01e08196g Lachancea lanzarotensis ammonium permease MEP3 XP_022626573.1 783227 D 1245769 CDS LALA0_S01e08262g 34683710 join(785831..786010,786012..786731) Unknown 1 NW_019212879.1 hypothetical protein; 786731 34683710 LALA0_S01e08262g Lachancea lanzarotensis 785831 D 1245769 CDS LALA0_S01e08284g 34683711 complement(786979..788700) Unknown 1 NW_019212879.1 highly similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein; uncharacterized protein 788700 34683711 LALA0_S01e08284g Lachancea lanzarotensis uncharacterized protein XP_022626574.1 786979 R 1245769 CDS LALA0_S01e08306g 34683712 complement(789012..791693) Unknown 1 NW_019212879.1 similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion; chromatin-binding protein CTF4 791693 34683712 LALA0_S01e08306g Lachancea lanzarotensis chromatin-binding protein CTF4 XP_022626575.1 789012 R 1245769 CDS LALA0_S01e08328g 34683713 792407..793162 Unknown 1 NW_019212879.1 similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG2 793162 34683713 LALA0_S01e08328g Lachancea lanzarotensis Golgi transport complex subunit COG2 XP_022626576.1 792407 D 1245769 CDS LALA0_S01e08350g 34683714 793371..795098 Unknown 1 NW_019212879.1 similar to uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p; FG-nucleoporin NUP57 795098 34683714 LALA0_S01e08350g Lachancea lanzarotensis FG-nucleoporin NUP57 XP_022626577.1 793371 D 1245769 CDS LALA0_S01e08372g 34683715 complement(795133..795984) Unknown 1 NW_019212879.1 weakly similar to uniprot|P08593 Saccharomyces cerevisiae YPR134W MSS18 Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions; uncharacterized protein 795984 34683715 LALA0_S01e08372g Lachancea lanzarotensis uncharacterized protein XP_022626578.1 795133 R 1245769 CDS LALA0_S01e08394g 34683716 complement(796231..796383) Unknown 1 NW_019212879.1 highly similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore; uncharacterized protein 796383 34683716 LALA0_S01e08394g Lachancea lanzarotensis uncharacterized protein XP_022626579.1 796231 R 1245769 CDS LALA0_S01e08416g 34683717 796819..797928 Unknown 1 NW_019212879.1 similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C SPN1 Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype; uncharacterized protein 797928 34683717 LALA0_S01e08416g Lachancea lanzarotensis uncharacterized protein XP_022626580.1 796819 D 1245769 CDS LALA0_S01e08438g 34683718 complement(join(798290..798662,798884..798948)) Unknown 1 NW_019212879.1 highly similar to uniprot|P0CX29 Saccharomyces cerevisiae YGR118W (ohnolog of YPR132W) RPS23A Ribosomalprotein 28 (rp28) of the small (40S) ribosomal subunit,required for translational accuracy; nearly identical toRps23Bp and similar to E. coli S12 and rat S23 ribosomalproteins; deletion of both RPS23A and RPS23B is lethal; 40S ribosomal protein uS12 798948 34683718 LALA0_S01e08438g Lachancea lanzarotensis 40S ribosomal protein uS12 XP_022626581.1 798290 R 1245769 CDS LALA0_S01e08460g 34683719 799908..801248 Unknown 1 NW_019212879.1 similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 801248 34683719 LALA0_S01e08460g Lachancea lanzarotensis uncharacterized protein XP_022626582.1 799908 D 1245769 CDS LALA0_S01e08482g 34683720 801334..801924 Unknown 1 NW_019212879.1 highly similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; peptide alpha-N-acetyltransferase complex B subunit NAT3 801924 34683720 LALA0_S01e08482g Lachancea lanzarotensis peptide alpha-N-acetyltransferase complex B subunit NAT3 XP_022626583.1 801334 D 1245769 CDS LALA0_S01e08504g 34683721 complement(802011..803030) Unknown 1 NW_019212879.1 similar to uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; uncharacterized protein 803030 34683721 LALA0_S01e08504g Lachancea lanzarotensis uncharacterized protein XP_022626584.1 802011 R 1245769 CDS LALA0_S01e08526g 34683722 804394..805374 Unknown 1 NW_019212879.1 similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; uncharacterized protein 805374 34683722 LALA0_S01e08526g Lachancea lanzarotensis uncharacterized protein XP_022626585.1 804394 D 1245769 CDS LALA0_S01e08548g 34683723 complement(805605..806861) Unknown 1 NW_019212879.1 similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W YLH47 Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome; uncharacterized protein 806861 34683723 LALA0_S01e08548g Lachancea lanzarotensis uncharacterized protein XP_022626586.1 805605 R 1245769 CDS LALA0_S01e08570g 34683724 complement(807264..808436) Unknown 1 NW_019212879.1 some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A; uncharacterized protein 808436 34683724 LALA0_S01e08570g Lachancea lanzarotensis uncharacterized protein XP_022626587.1 807264 R 1245769 CDS LALA0_S01e08592g 34683725 complement(810493..814860) Unknown 1 NW_019212879.1 highly similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region; chromatin-remodeling histone chaperone SPT6 814860 34683725 LALA0_S01e08592g Lachancea lanzarotensis chromatin-remodeling histone chaperone SPT6 XP_022626588.1 810493 R 1245769 CDS LALA0_S01e08614g 34683726 complement(815130..816227) Unknown 1 NW_019212879.1 similar to uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; high-affinity Cu transporter CTR1 816227 34683726 LALA0_S01e08614g Lachancea lanzarotensis high-affinity Cu transporter CTR1 XP_022626589.1 815130 R 1245769 CDS LALA0_S01e08636g 34683727 complement(816636..817541) Unknown 1 NW_019212879.1 similar to uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; uncharacterized protein 817541 34683727 LALA0_S01e08636g Lachancea lanzarotensis uncharacterized protein XP_022626590.1 816636 R 1245769 CDS LALA0_S01e08658g 34683728 complement(818184..819278) Unknown 1 NW_019212879.1 similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W SHY1 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; uncharacterized protein 819278 34683728 LALA0_S01e08658g Lachancea lanzarotensis uncharacterized protein XP_022626591.1 818184 R 1245769 CDS LALA0_S01e08680g 34683729 complement(819673..820617) Unknown 1 NW_019212879.1 highly similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS5m 820617 34683729 LALA0_S01e08680g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS5m XP_022626592.1 819673 R 1245769 CDS LALA0_S01e08702g 34683730 822074..822907 Unknown 1 NW_019212879.1 some similarities with uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity; uncharacterized protein 822907 34683730 LALA0_S01e08702g Lachancea lanzarotensis uncharacterized protein XP_022626593.1 822074 D 1245769 CDS LALA0_S01e08724g 34683731 824976..827213 Unknown 1 NW_019212879.1 similar to uniprot|P39925 Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; AAA family ATPase AFG3 827213 34683731 LALA0_S01e08724g Lachancea lanzarotensis AAA family ATPase AFG3 XP_022626594.1 824976 D 1245769 CDS LALA0_S01e08746g 34683732 complement(827319..828320) Unknown 1 NW_019212879.1 similar to uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; microtubule-binding protein BIM1 828320 34683732 LALA0_S01e08746g Lachancea lanzarotensis microtubule-binding protein BIM1 XP_022626595.1 827319 R 1245769 CDS LALA0_S01e08768g 34683733 829518..830666 Unknown 1 NW_019212879.1 weakly similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; uncharacterized protein 830666 34683733 LALA0_S01e08768g Lachancea lanzarotensis uncharacterized protein XP_022626596.1 829518 D 1245769 CDS LALA0_S01e08790g 34683734 complement(830725..832980) Unknown 1 NW_019212879.1 similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; medium-chain fatty acid-CoA ligase FAA2 832980 34683734 LALA0_S01e08790g Lachancea lanzarotensis medium-chain fatty acid-CoA ligase FAA2 XP_022626597.1 830725 R 1245769 CDS LALA0_S01e08812g 34683735 complement(833341..833694) Unknown 1 NW_019212879.1 similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members; U2 snRNP complex subunit MSL1 833694 34683735 LALA0_S01e08812g Lachancea lanzarotensis U2 snRNP complex subunit MSL1 XP_022626598.1 833341 R 1245769 CDS LALA0_S01e08834g 34683736 complement(833879..835453) Unknown 1 NW_019212879.1 similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides; oxygen-dependent protoporphyrinogen oxidase 835453 34683736 LALA0_S01e08834g Lachancea lanzarotensis oxygen-dependent protoporphyrinogen oxidase XP_022626599.1 833879 R 1245769 CDS LALA0_S01e08856g 34683737 complement(835971..839294) Unknown 1 NW_019212879.1 similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; DEAH-box ATP-dependent RNA helicase PRP22 839294 34683737 LALA0_S01e08856g Lachancea lanzarotensis DEAH-box ATP-dependent RNA helicase PRP22 XP_022626600.1 835971 R 1245769 CDS LALA0_S01e08878g 34683738 complement(840015..840602) Unknown 1 NW_019212879.1 highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; proteasome core particle subunit beta 4 840602 34683738 LALA0_S01e08878g Lachancea lanzarotensis proteasome core particle subunit beta 4 XP_022626601.1 840015 R 1245769 CDS LALA0_S01e08900g 34683739 841683..842921 Unknown 1 NW_019212879.1 highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair; DNA primase subunit PRI1 842921 34683739 LALA0_S01e08900g Lachancea lanzarotensis DNA primase subunit PRI1 XP_022626602.1 841683 D 1245769 CDS LALA0_S01e08922g 34683740 complement(843011..845248) Unknown 1 NW_019212879.1 similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene; hydrolase 845248 34683740 LALA0_S01e08922g Lachancea lanzarotensis hydrolase XP_022626603.1 843011 R 1245769 CDS LALA0_S01e08944g 34683741 847063..847788 Unknown 1 NW_019212879.1 similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Putative protein of unknown function; YIR042C is a non-essential gene; uncharacterized protein 847788 34683741 LALA0_S01e08944g Lachancea lanzarotensis uncharacterized protein XP_022626604.1 847063 D 1245769 CDS LALA0_S01e08966g 34683742 complement(848119..849795) Unknown 1 NW_019212879.1 similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome; ribosome-binding protein MDM38 849795 34683742 LALA0_S01e08966g Lachancea lanzarotensis ribosome-binding protein MDM38 XP_022626605.1 848119 R 1245769 CDS LALA0_S01e08988g 34683743 850516..851163 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene; uncharacterized protein 851163 34683743 LALA0_S01e08988g Lachancea lanzarotensis uncharacterized protein XP_022626606.1 850516 D 1245769 CDS LALA0_S01e09010g 34683744 851257..851739 Unknown 1 NW_019212879.1 similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; ribonuclease P protein subunit RPR2 851739 34683744 LALA0_S01e09010g Lachancea lanzarotensis ribonuclease P protein subunit RPR2 XP_022626607.1 851257 D 1245769 CDS LALA0_S01e09032g 34683745 complement(851848..852249) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein, involved in the insertion of TOM (translocase of outer membrane) complex components into the membrane and required for assembly of the TOM complex; mutants display impaired mitochondrial protein import; uncharacterized protein 852249 34683745 LALA0_S01e09032g Lachancea lanzarotensis uncharacterized protein XP_022626608.1 851848 R 1245769 CDS LALA0_S01e09054g 34683746 join(852892..852926,852993..853722) Unknown 1 NW_019212879.1 highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; proteasome core particle subunit alpha 4 853722 34683746 LALA0_S01e09054g Lachancea lanzarotensis proteasome core particle subunit alpha 4 XP_022626609.1 852892 D 1245769 CDS LALA0_S01e09076g 34683747 853969..855315 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z; uncharacterized protein 855315 34683747 LALA0_S01e09076g Lachancea lanzarotensis uncharacterized protein XP_022626610.1 853969 D 1245769 CDS LALA0_S01e09098g 34683748 856493..859033 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40572 Saccharomyces cerevisiae YIR016W (ohnolog of YOL036W) Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene; uncharacterized protein 859033 34683748 LALA0_S01e09098g Lachancea lanzarotensis uncharacterized protein XP_022626611.1 856493 D 1245769 CDS LALA0_S01e09120g 34683749 complement(859278..860093) Unknown 1 NW_019212879.1 some similarities with uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism; uncharacterized protein 860093 34683749 LALA0_S01e09120g Lachancea lanzarotensis uncharacterized protein XP_022626612.1 859278 R 1245769 CDS LALA0_S01e09164g 34683751 861425..863266 Unknown 1 NW_019212879.1 similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation; uncharacterized protein 863266 34683751 LALA0_S01e09164g Lachancea lanzarotensis uncharacterized protein XP_022626613.1 861425 D 1245769 CDS LALA0_S01e09186g 34683752 863597..867874 Unknown 1 NW_019212879.1 similar to uniprot|P32521 Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease; uncharacterized protein 867874 34683752 LALA0_S01e09186g Lachancea lanzarotensis uncharacterized protein XP_022626614.1 863597 D 1245769 CDS LALA0_S01e09208g 34683753 complement(867921..868457) Unknown 1 NW_019212879.1 similar to uniprot|P40565 Saccharomyces cerevisiae YIR005W IST3 Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; U2 snRNP complex subunit IST3 868457 34683753 LALA0_S01e09208g Lachancea lanzarotensis U2 snRNP complex subunit IST3 XP_022626615.1 867921 R 1245769 CDS LALA0_S01e09230g 34683754 868670..869383 Unknown 1 NW_019212879.1 similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction; bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase 869383 34683754 LALA0_S01e09230g Lachancea lanzarotensis bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase XP_022626616.1 868670 D 1245769 CDS LALA0_S01e09252g 34683755 complement(869500..870753) Unknown 1 NW_019212879.1 similar to uniprot|P40564 Saccharomyces cerevisiae YIR004W DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ; uncharacterized protein 870753 34683755 LALA0_S01e09252g Lachancea lanzarotensis uncharacterized protein XP_022626617.1 869500 R 1245769 CDS LALA0_S01e09274g 34683756 complement(join(871538..873256,873353..873415)) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40563 Saccharomyces cerevisiae YIR003W AIM21 Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; uncharacterized protein 873415 34683756 LALA0_S01e09274g Lachancea lanzarotensis uncharacterized protein XP_022626618.1 871538 R 1245769 CDS LALA0_S01e09296g 34683757 complement(873831..874208) Unknown 1 NW_019212879.1 highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; Ran GTPase-binding protein NTF2 874208 34683757 LALA0_S01e09296g Lachancea lanzarotensis Ran GTPase-binding protein NTF2 XP_022626619.1 873831 R 1245769 CDS LALA0_S01e09318g 34683758 874557..878372 Unknown 1 NW_019212879.1 similar to uniprot|P33332 Saccharomyces cerevisiae YER008C SEC3 Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion; GTP-Rho binding exocyst subunit SEC3 878372 34683758 LALA0_S01e09318g Lachancea lanzarotensis GTP-Rho binding exocyst subunit SEC3 XP_022626620.1 874557 D 1245769 CDS LALA0_S01e09340g 34683759 878533..881616 Unknown 1 NW_019212879.1 similar to uniprot|P40562 Saccharomyces cerevisiae YIR002C MPH1 Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype; 3'-5' DNA helicase 881616 34683759 LALA0_S01e09340g Lachancea lanzarotensis 3'-5' DNA helicase XP_022626621.1 878533 D 1245769 CDS LALA0_S01e09384g 34683761 join(882379..882389,882469..883003) Unknown 1 NW_019212879.1 highly similar to uniprot|P89886 Saccharomyces cerevisiae YER007C-A TMA20 Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; translation machinery-associated protein 20 883003 34683761 LALA0_S01e09384g Lachancea lanzarotensis translation machinery-associated protein 20 XP_022626622.1 882379 D 1245769 CDS LALA0_S01e09406g 34683762 complement(883082..884563) Unknown 1 NW_019212879.1 similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl; uncharacterized protein 884563 34683762 LALA0_S01e09406g Lachancea lanzarotensis uncharacterized protein XP_022626623.1 883082 R 1245769 CDS LALA0_S01e09428g 34683763 complement(884859..886433) Unknown 1 NW_019212879.1 highly similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus; RNA-binding GTPase NUG1 886433 34683763 LALA0_S01e09428g Lachancea lanzarotensis RNA-binding GTPase NUG1 XP_022626624.1 884859 R 1245769 CDS LALA0_S01e09450g 34683764 886854..887927 Unknown 1 NW_019212879.1 similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; transcription factor TFIIB 887927 34683764 LALA0_S01e09450g Lachancea lanzarotensis transcription factor TFIIB XP_022626625.1 886854 D 1245769 CDS LALA0_S01e09472g 34683765 complement(888000..889958) Unknown 1 NW_019212879.1 similar to uniprot|P40009 Saccharomyces cerevisiae YER005W YND1 Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity; apyrase 889958 34683765 LALA0_S01e09472g Lachancea lanzarotensis apyrase XP_022626626.1 888000 R 1245769 CDS LALA0_S01e09494g 34683766 complement(890274..890897) Unknown 1 NW_019212879.1 similar to Lachancea thermotolerans KLTH0F12980g hypothetical protein; uncharacterized protein 890897 34683766 LALA0_S01e09494g Lachancea lanzarotensis uncharacterized protein XP_022626627.1 890274 R 1245769 CDS LALA0_S01e09516g 34683767 join(891097..891127,891195..892453) Unknown 1 NW_019212879.1 highly similar to uniprot|P29952 Saccharomyces cerevisiae YER003C PMI40 Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation; mannose-6-phosphate isomerase PMI40 892453 34683767 LALA0_S01e09516g Lachancea lanzarotensis mannose-6-phosphate isomerase PMI40 XP_022626628.1 891097 D 1245769 CDS LALA0_S01e09538g 34683768 complement(892578..893273) Unknown 1 NW_019212879.1 similar to uniprot|P40007 Saccharomyces cerevisiae YER002W NOP16 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; uncharacterized protein 893273 34683768 LALA0_S01e09538g Lachancea lanzarotensis uncharacterized protein XP_022626629.1 892578 R 1245769 CDS LALA0_S01e09560g 34683769 893529..893993 Unknown 1 NW_019212879.1 some similarities with uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation; uncharacterized protein 893993 34683769 LALA0_S01e09560g Lachancea lanzarotensis uncharacterized protein XP_022626630.1 893529 D 1245769 CDS LALA0_S01e09604g 34683770 894681..895388 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C IRC22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci; uncharacterized protein 895388 34683770 LALA0_S01e09604g Lachancea lanzarotensis uncharacterized protein XP_022626631.1 894681 D 1245769 CDS LALA0_S01e09626g 34683771 complement(895458..897020) Unknown 1 NW_019212879.1 similar to uniprot|P40560 Saccharomyces cerevisiae YIL001W Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm; uncharacterized protein 897020 34683771 LALA0_S01e09626g Lachancea lanzarotensis uncharacterized protein XP_022626632.1 895458 R 1245769 CDS LALA0_S01e09648g 34683772 897141..899954 Unknown 1 NW_019212879.1 similar to uniprot|P40559 Saccharomyces cerevisiae YIL002C INP51 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth; phosphoinositide 5-phosphatase INP51 899954 34683772 LALA0_S01e09648g Lachancea lanzarotensis phosphoinositide 5-phosphatase INP51 XP_022626633.1 897141 D 1245769 CDS LALA0_S01e09670g 34683773 complement(899986..900210) Unknown 1 NW_019212879.1 weakly similar to uniprot|C5DF88 Lachancea thermotolerans KLTH0D13134g hypothetical protein; uncharacterized protein 900210 34683773 LALA0_S01e09670g Lachancea lanzarotensis uncharacterized protein XP_022626634.1 899986 R 1245769 CDS LALA0_S01e09692g 34683774 900376..901662 Unknown 1 NW_019212879.1 similar to uniprot|P33767 Saccharomyces cerevisiae YEL002C WBP1 Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; dolichyl-diphosphooligosaccharide-protein glycotransferase 901662 34683774 LALA0_S01e09692g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_022626635.1 900376 D 1245769 CDS LALA0_S01e09714g 34683775 complement(join(901729..902045,902106..902124)) Unknown 1 NW_019212879.1 highly similar to uniprot|P40005 Saccharomyces cerevisiae YEL003W GIM4 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; tubulin-binding prefolding complex subunit GIM4 902124 34683775 LALA0_S01e09714g Lachancea lanzarotensis tubulin-binding prefolding complex subunit GIM4 XP_022626636.1 901729 R 1245769 CDS LALA0_S01e09736g 34683776 903077..903970 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter; uncharacterized protein 903970 34683776 LALA0_S01e09736g Lachancea lanzarotensis uncharacterized protein XP_022626637.1 903077 D 1245769 CDS LALA0_S01e09758g 34683777 complement(904016..904861) Unknown 1 NW_019212879.1 similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol; iron-sulfur cluster assembly protein CFD1 904861 34683777 LALA0_S01e09758g Lachancea lanzarotensis iron-sulfur cluster assembly protein CFD1 XP_022626638.1 904016 R 1245769 CDS LALA0_S01e09780g 34683778 join(905088..905098,905169..905583) Unknown 1 NW_019212879.1 similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C BET1 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; uncharacterized protein 905583 34683778 LALA0_S01e09780g Lachancea lanzarotensis uncharacterized protein XP_022626639.1 905088 D 1245769 CDS LALA0_S01e09802g 34683779 complement(905642..907744) Unknown 1 NW_019212879.1 similar to uniprot|P40557 Saccharomyces cerevisiae YIL005W EPS1 ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family; protein disulfide isomerase EPS1 907744 34683779 LALA0_S01e09802g Lachancea lanzarotensis protein disulfide isomerase EPS1 XP_022626640.1 905642 R 1245769 CDS LALA0_S01e09824g 34683780 complement(907959..909110) Unknown 1 NW_019212879.1 similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W (ohnolog of YEL006W) YIA6 Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; NAD+ transporter 909110 34683780 LALA0_S01e09824g Lachancea lanzarotensis NAD+ transporter XP_022626641.1 907959 R 1245769 CDS LALA0_S01e09846g 34683781 911991..912800 Unknown 1 NW_019212879.1 similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; amino acid starvation-responsive transcription factor GCN4 912800 34683781 LALA0_S01e09846g Lachancea lanzarotensis amino acid starvation-responsive transcription factor GCN4 XP_022626642.1 911991 D 1245769 CDS LALA0_S01e09868g 34683782 join(912984..913430,913494..913712) Unknown 1 NW_019212879.1 similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C NAS2 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; uncharacterized protein 913712 34683782 LALA0_S01e09868g Lachancea lanzarotensis uncharacterized protein XP_022626643.1 912984 D 1245769 CDS LALA0_S01e09890g 34683783 complement(913759..914064) Unknown 1 NW_019212879.1 highly similar to uniprot|P40554 Saccharomyces cerevisiae YIL008W URM1 Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response; ubiquitin-related modifier URM1 914064 34683783 LALA0_S01e09890g Lachancea lanzarotensis ubiquitin-related modifier URM1 XP_022626644.1 913759 R 1245769 CDS LALA0_S01e09978g 34683787 join(915944..916225,916227..916544) Unknown 1 NW_019212879.1 similar to uniprot|Q03096 Saccharomyces cerevisiae YIL009C-A EST3 Component of the telomerase holoenzyme, involved in telomere replication; telomerase subunit EST3 916544 34683787 LALA0_S01e09978g Lachancea lanzarotensis telomerase subunit EST3 XP_022626645.1 915944 D 1245769 CDS LALA0_S01e10000g 34683788 916916..918241 Unknown 1 NW_019212879.1 highly similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting; uncharacterized protein 918241 34683788 LALA0_S01e10000g Lachancea lanzarotensis uncharacterized protein XP_022626646.1 916916 D 1245769 CDS LALA0_S01e10022g 34683789 complement(918371..919387) Unknown 1 NW_019212879.1 some similarities with uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth; thioredoxin peroxidase DOT5 919387 34683789 LALA0_S01e10022g Lachancea lanzarotensis thioredoxin peroxidase DOT5 XP_022626647.1 918371 R 1245769 CDS LALA0_S01e10044g 34683790 complement(919733..921544) Unknown 1 NW_019212879.1 similar to uniprot|Q08977 Saccharomyces cerevisiae YPL260W Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; uncharacterized protein 921544 34683790 LALA0_S01e10044g Lachancea lanzarotensis uncharacterized protein XP_022626648.1 919733 R 1245769 CDS LALA0_S01e10066g 34683791 complement(922151..923161) Unknown 1 NW_019212879.1 similar to uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response; uncharacterized protein 923161 34683791 LALA0_S01e10066g Lachancea lanzarotensis uncharacterized protein XP_022626649.1 922151 R 1245769 CDS LALA0_S01e10088g 34683792 923386..924126 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40574 Saccharomyces cerevisiae YIR018W (ohnolog of YOL028C) YAP5 Basic leucine zipper (bZIP) transcription factor; uncharacterized protein 924126 34683792 LALA0_S01e10088g Lachancea lanzarotensis uncharacterized protein XP_022626650.1 923386 D 1245769 CDS LALA0_S01e10110g 34683793 complement(924165..925598) Unknown 1 NW_019212879.1 similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall; 1,3-beta-glucanosyltransferase 925598 34683793 LALA0_S01e10110g Lachancea lanzarotensis 1,3-beta-glucanosyltransferase XP_022626651.1 924165 R 1245769 CDS LALA0_S01e10176g 34683796 926874..927395 Unknown 1 NW_019212879.1 similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; acireductone dioxygenase (Ni2+-requiring) 927395 34683796 LALA0_S01e10176g Lachancea lanzarotensis acireductone dioxygenase (Ni2+-requiring) XP_022626652.1 926874 D 1245769 CDS LALA0_S01e10198g 34683797 927776..928855 Unknown 1 NW_019212879.1 similar to uniprot|Q03687 Saccharomyces cerevisiae YMR010W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1; uncharacterized protein 928855 34683797 LALA0_S01e10198g Lachancea lanzarotensis uncharacterized protein XP_022626653.1 927776 D 1245769 CDS LALA0_S01e10220g 34683798 complement(928943..931189) Unknown 1 NW_019212879.1 similar to uniprot|P32606 Saccharomyces cerevisiae YOR017W PET127 Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane; uncharacterized protein 931189 34683798 LALA0_S01e10220g Lachancea lanzarotensis uncharacterized protein XP_022626654.1 928943 R 1245769 CDS LALA0_S01e10242g 34683799 931845..933284 Unknown 1 NW_019212879.1 similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C AIM17 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; uncharacterized protein 933284 34683799 LALA0_S01e10242g Lachancea lanzarotensis uncharacterized protein XP_022626655.1 931845 D 1245769 CDS LALA0_S01e10264g 34683800 933437..934588 Unknown 1 NW_019212879.1 weakly similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation; DNA topoisomerase (ATP-hydrolyzing) 934588 34683800 LALA0_S01e10264g Lachancea lanzarotensis DNA topoisomerase (ATP-hydrolyzing) XP_022626656.1 933437 D 1245769 CDS LALA0_S01e10308g 34683802 935214..935846 Unknown 1 NW_019212879.1 highly similar to uniprot|P39704 Saccharomyces cerevisiae YAL007C (ohnolog of YOR016C) ERP2 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; uncharacterized protein 935846 34683802 LALA0_S01e10308g Lachancea lanzarotensis uncharacterized protein XP_022626657.1 935214 D 1245769 CDS LALA0_S01e10330g 34683803 936222..937448 Unknown 1 NW_019212879.1 highly similar to uniprot|Q06103 Saccharomyces cerevisiae YPR108W RPN7 Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits; proteasome regulatory particle lid subunit RPN7 937448 34683803 LALA0_S01e10330g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN7 XP_022626658.1 936222 D 1245769 CDS LALA0_S01e10352g 34683804 938668..940329 Unknown 1 NW_019212879.1 highly similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide; catalase T 940329 34683804 LALA0_S01e10352g Lachancea lanzarotensis catalase T XP_022626659.1 938668 D 1245769 CDS LALA0_S01e10396g 34683806 complement(941028..945251) Unknown 1 NW_019212879.1 similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene; uncharacterized protein 945251 34683806 LALA0_S01e10396g Lachancea lanzarotensis uncharacterized protein XP_022626660.1 941028 R 1245769 CDS LALA0_S01e10418g 34683807 join(945439..945476,945603..946038) Unknown 1 NW_019212879.1 highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC); E2 SUMO-conjugating protein UBC9 946038 34683807 LALA0_S01e10418g Lachancea lanzarotensis E2 SUMO-conjugating protein UBC9 XP_022626661.1 945439 D 1245769 CDS LALA0_S01e10440g 34683808 complement(946137..947990) Unknown 1 NW_019212879.1 similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; uncharacterized protein 947990 34683808 LALA0_S01e10440g Lachancea lanzarotensis uncharacterized protein XP_022626662.1 946137 R 1245769 CDS LALA0_S01e10462g 34683809 complement(948749..949036) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 949036 34683809 LALA0_S01e10462g Lachancea lanzarotensis uncharacterized protein XP_022626663.1 948749 R 1245769 CDS LALA0_S01e10484g 34683810 949263..952289 Unknown 1 NW_019212879.1 similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family; metalloendopeptidase 952289 34683810 LALA0_S01e10484g Lachancea lanzarotensis metalloendopeptidase XP_022626664.1 949263 D 1245769 CDS LALA0_S01e10506g 34683811 complement(953048..953218) Unknown 1 NW_019212879.1 highly similar to uniprot|P41058 Saccharomyces cerevisiae YDL061C (ohnolog of YLR388W) RPS29B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins; 40S ribosomal protein uS14 953218 34683811 LALA0_S01e10506g Lachancea lanzarotensis 40S ribosomal protein uS14 XP_022626665.1 953048 R 1245769 CDS LALA0_S01e10528g 34683812 954254..956635 Unknown 1 NW_019212879.1 similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; uncharacterized protein 956635 34683812 LALA0_S01e10528g Lachancea lanzarotensis uncharacterized protein XP_022626666.1 954254 D 1245769 CDS LALA0_S01e10550g 34683813 957155..958420 Unknown 1 NW_019212879.1 similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains; uncharacterized protein 958420 34683813 LALA0_S01e10550g Lachancea lanzarotensis uncharacterized protein XP_022626667.1 957155 D 1245769 CDS LALA0_S01e10572g 34683814 complement(join(958832..961416,961508..961511)) Unknown 1 NW_019212879.1 similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p; uncharacterized protein 961511 34683814 LALA0_S01e10572g Lachancea lanzarotensis uncharacterized protein XP_022626668.1 958832 R 1245769 CDS LALA0_S01e10594g 34683815 961683..962093 Unknown 1 NW_019212879.1 similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; uncharacterized protein 962093 34683815 LALA0_S01e10594g Lachancea lanzarotensis uncharacterized protein XP_022626669.1 961683 D 1245769 CDS LALA0_S01e10616g 34683816 962305..966273 Unknown 1 NW_019212879.1 similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD); Elongator subunit IKI3 966273 34683816 LALA0_S01e10616g Lachancea lanzarotensis Elongator subunit IKI3 XP_022626670.1 962305 D 1245769 CDS LALA0_S01e10638g 34683817 complement(966304..966924) Unknown 1 NW_019212879.1 similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p; uncharacterized protein 966924 34683817 LALA0_S01e10638g Lachancea lanzarotensis uncharacterized protein XP_022626671.1 966304 R 1245769 CDS LALA0_S01e10660g 34683818 968049..973193 Unknown 1 NW_019212879.1 similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex; uncharacterized protein 973193 34683818 LALA0_S01e10660g Lachancea lanzarotensis uncharacterized protein XP_022626672.1 968049 D 1245769 CDS LALA0_S01e10682g 34683819 complement(973376..976687) Unknown 1 NW_019212879.1 similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W SMC6 Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18; DNA repair protein SMC6 976687 34683819 LALA0_S01e10682g Lachancea lanzarotensis DNA repair protein SMC6 XP_022626673.1 973376 R 1245769 CDS LALA0_S01e10704g 34683820 978805..981447 Unknown 1 NW_019212879.1 similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; leucine--tRNA ligase NAM2 981447 34683820 LALA0_S01e10704g Lachancea lanzarotensis leucine--tRNA ligase NAM2 XP_022626674.1 978805 D 1245769 CDS LALA0_S01e10726g 34683821 complement(981657..983681) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; uncharacterized protein 983681 34683821 LALA0_S01e10726g Lachancea lanzarotensis uncharacterized protein XP_022626675.1 981657 R 1245769 CDS LALA0_S01e10748g 34683822 complement(983895..985247) Unknown 1 NW_019212879.1 similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; uncharacterized protein 985247 34683822 LALA0_S01e10748g Lachancea lanzarotensis uncharacterized protein XP_022626676.1 983895 R 1245769 CDS LALA0_S01e10770g 34683823 985927..987780 Unknown 1 NW_019212879.1 some similarities with uniprot|Q07379 Saccharomyces cerevisiae YDL057W Putative protein of unknown function; YDL057W is not an essential gene; uncharacterized protein 987780 34683823 LALA0_S01e10770g Lachancea lanzarotensis uncharacterized protein XP_022626677.1 985927 D 1245769 CDS LALA0_S01e10792g 34683824 988984..991266 Unknown 1 NW_019212879.1 similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes; transcription factor MBP1 991266 34683824 LALA0_S01e10792g Lachancea lanzarotensis transcription factor MBP1 XP_022626678.1 988984 D 1245769 CDS LALA0_S01e10814g 34683825 complement(991408..992493) Unknown 1 NW_019212879.1 highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; mannose-1-phosphate guanylyltransferase 992493 34683825 LALA0_S01e10814g Lachancea lanzarotensis mannose-1-phosphate guanylyltransferase XP_022626679.1 991408 R 1245769 CDS LALA0_S01e10836g 34683826 complement(994902..996863) Unknown 1 NW_019212879.1 similar to uniprot|P38196 Saccharomyces cerevisiae YBL042C FUI1 High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; uridine permease 996863 34683826 LALA0_S01e10836g Lachancea lanzarotensis uridine permease XP_022626680.1 994902 R 1245769 CDS LALA0_S01e10880g 34683828 complement(1001873..1003315) Unknown 1 NW_019212879.1 highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER; translocon subunit SEC61 1003315 34683828 LALA0_S01e10880g Lachancea lanzarotensis translocon subunit SEC61 XP_022626681.1 1001873 R 1245769 CDS LALA0_S01e10902g 34683829 complement(1005017..1006387) Unknown 1 NW_019212879.1 similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C MCH1 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; uncharacterized protein 1006387 34683829 LALA0_S01e10902g Lachancea lanzarotensis uncharacterized protein XP_022626682.1 1005017 R 1245769 CDS LALA0_S01e10924g 34683830 complement(1006766..1007185) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; uncharacterized protein 1007185 34683830 LALA0_S01e10924g Lachancea lanzarotensis uncharacterized protein XP_022626683.1 1006766 R 1245769 CDS LALA0_S01e10946g 34683831 1008614..1009657 Unknown 1 NW_019212879.1 highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p; fructose 1,6-bisphosphate 1-phosphatase 1009657 34683831 LALA0_S01e10946g Lachancea lanzarotensis fructose 1,6-bisphosphate 1-phosphatase XP_022626684.1 1008614 D 1245769 CDS LALA0_S01e10968g 34683832 complement(1009752..1010675) Unknown 1 NW_019212879.1 similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes; 1-acylglycerol-3-phosphate O-acyltransferase SLC1 1010675 34683832 LALA0_S01e10968g Lachancea lanzarotensis 1-acylglycerol-3-phosphate O-acyltransferase SLC1 XP_022626685.1 1009752 R 1245769 CDS LALA0_S01e10990g 34683833 join(1011649..1011690,1011762..1012445) Unknown 1 NW_019212879.1 similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C PSY3 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C; uncharacterized protein 1012445 34683833 LALA0_S01e10990g Lachancea lanzarotensis uncharacterized protein XP_022626686.1 1011649 D 1245769 CDS LALA0_S01e11012g 34683834 1012764..1013597 Unknown 1 NW_019212879.1 similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen; uncharacterized protein 1013597 34683834 LALA0_S01e11012g Lachancea lanzarotensis uncharacterized protein XP_022626687.1 1012764 D 1245769 CDS LALA0_S01e11034g 34683835 complement(1013713..1014513) Unknown 1 NW_019212879.1 similar to uniprot|P50112 Saccharomyces cerevisiae YDL049C KNH1 Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance; uncharacterized protein 1014513 34683835 LALA0_S01e11034g Lachancea lanzarotensis uncharacterized protein XP_022626688.1 1013713 R 1245769 CDS LALA0_S01e11056g 34683836 1017267..1018580 Unknown 1 NW_019212879.1 similar to Lachancea thermotolerans KLTH0D13640g hypothetical protein; uncharacterized protein 1018580 34683836 LALA0_S01e11056g Lachancea lanzarotensis uncharacterized protein XP_022626689.1 1017267 D 1245769 CDS LALA0_S01e11078g 34683837 join(1020347..1021528,1021528..1021590) Unknown 1 NW_019212879.1 hypothetical protein; 1021590 34683837 LALA0_S01e11078g Lachancea lanzarotensis 1020347 D 1245769 CDS LALA0_S01e11100g 34683838 complement(1022145..1023134) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C (ohnolog of YLR375W) STP4 Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; uncharacterized protein 1023134 34683838 LALA0_S01e11100g Lachancea lanzarotensis uncharacterized protein XP_022626690.1 1022145 R 1245769 CDS LALA0_S01e11122g 34683839 complement(1024689..1025828) Unknown 1 NW_019212879.1 similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; fatty acid elongase ELO3 1025828 34683839 LALA0_S01e11122g Lachancea lanzarotensis fatty acid elongase ELO3 XP_022626691.1 1024689 R 1245769 CDS LALA0_S01e11144g 34683840 complement(1026144..1030028) Unknown 1 NW_019212879.1 similar to uniprot|P53046 Saccharomyces cerevisiae YGR070W (ohnolog of YLR371W) ROM1 GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; Rho family guanine nucleotide exchange factor ROM2 1030028 34683840 LALA0_S01e11144g Lachancea lanzarotensis Rho family guanine nucleotide exchange factor ROM2 XP_022626692.1 1026144 R 1245769 CDS LALA0_S01e11166g 34683841 join(1031613..1031618,1031685..1032209) Unknown 1 NW_019212879.1 highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; uncharacterized protein 1032209 34683841 LALA0_S01e11166g Lachancea lanzarotensis uncharacterized protein XP_022626693.1 1031613 D 1245769 CDS LALA0_S01e11188g 34683842 complement(1032320..1034239) Unknown 1 NW_019212879.1 highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia; Hsp70 family ATPase SSQ1 1034239 34683842 LALA0_S01e11188g Lachancea lanzarotensis Hsp70 family ATPase SSQ1 XP_022626694.1 1032320 R 1245769 CDS LALA0_S01e11210g 34683843 complement(1035077..1036852) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains; SCF ubiquitin ligase complex subunit MDM30 1036852 34683843 LALA0_S01e11210g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit MDM30 XP_022626695.1 1035077 R 1245769 CDS LALA0_S01e11232g 34683844 1037093..1039000 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C ART5 Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; uncharacterized protein 1039000 34683844 LALA0_S01e11232g Lachancea lanzarotensis uncharacterized protein XP_022626696.1 1037093 D 1245769 CDS LALA0_S01e11254g 34683845 complement(join(1039203..1039462,1039794..1039926)) Unknown 1 NW_019212879.1 highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins; 40S ribosomal protein uS8 1039926 34683845 LALA0_S01e11254g Lachancea lanzarotensis 40S ribosomal protein uS8 XP_022626697.1 1039203 R 1245769 CDS LALA0_S01e11276g 34683846 1041397..1043193 Unknown 1 NW_019212879.1 highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin; uncharacterized protein 1043193 34683846 LALA0_S01e11276g Lachancea lanzarotensis uncharacterized protein XP_022626698.1 1041397 D 1245769 CDS LALA0_S01e11298g 34683847 complement(1043314..1043640) Unknown 1 NW_019212879.1 similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W GRX8 Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic; glutathione-disulfide reductase GRX8 1043640 34683847 LALA0_S01e11298g Lachancea lanzarotensis glutathione-disulfide reductase GRX8 XP_022626699.1 1043314 R 1245769 CDS LALA0_S01e11320g 34683848 1044007..1044315 Unknown 1 NW_019212879.1 highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p; transcription elongation factor SPT4 1044315 34683848 LALA0_S01e11320g Lachancea lanzarotensis transcription elongation factor SPT4 XP_022626700.1 1044007 D 1245769 CDS LALA0_S01e11342g 34683849 1044875..1045816 Unknown 1 NW_019212879.1 similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C COX18 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; membrane insertase COX18 1045816 34683849 LALA0_S01e11342g Lachancea lanzarotensis membrane insertase COX18 XP_022626701.1 1044875 D 1245769 CDS LALA0_S01e11364g 34683850 complement(1045928..1046188) Unknown 1 NW_019212879.1 highly similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; uncharacterized protein 1046188 34683850 LALA0_S01e11364g Lachancea lanzarotensis uncharacterized protein XP_022626702.1 1045928 R 1245769 CDS LALA0_S01e11386g 34683851 1047040..1051080 Unknown 1 NW_019212879.1 highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; phosphoribosylformylglycinamidine synthase 1051080 34683851 LALA0_S01e11386g Lachancea lanzarotensis phosphoribosylformylglycinamidine synthase XP_022626703.1 1047040 D 1245769 CDS LALA0_S01e11408g 34683852 complement(1051290..1052219) Unknown 1 NW_019212879.1 highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; methylsterol monooxygenase 1052219 34683852 LALA0_S01e11408g Lachancea lanzarotensis methylsterol monooxygenase XP_022626704.1 1051290 R 1245769 CDS LALA0_S01e11430g 34683853 1053735..1054406 Unknown 1 NW_019212879.1 similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway; uncharacterized protein 1054406 34683853 LALA0_S01e11430g Lachancea lanzarotensis uncharacterized protein XP_022626705.1 1053735 D 1245769 CDS LALA0_S01e11452g 34683854 complement(join(1055175..1056143,1056223..1056267)) Unknown 1 NW_019212879.1 similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W PEF1 Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; uncharacterized protein 1056267 34683854 LALA0_S01e11452g Lachancea lanzarotensis uncharacterized protein XP_022626706.1 1055175 R 1245769 CDS LALA0_S01e11474g 34683855 complement(join(1056995..1057260,1057562..1057613)) Unknown 1 NW_019212879.1 highly similar to uniprot|Q08745 Saccharomyces cerevisiae YOR293W (ohnolog of YMR230W) RPS10A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10; 40S ribosomal protein eS10 1057613 34683855 LALA0_S01e11474g Lachancea lanzarotensis 40S ribosomal protein eS10 XP_022626707.1 1056995 R 1245769 CDS LALA0_S01e11496g 34683856 1058653..1059624 Unknown 1 NW_019212879.1 similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; uncharacterized protein 1059624 34683856 LALA0_S01e11496g Lachancea lanzarotensis uncharacterized protein XP_022626708.1 1058653 D 1245769 CDS LALA0_S01e11518g 34683857 complement(1059657..1064054) Unknown 1 NW_019212879.1 similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W YPK9 Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; uncharacterized protein 1064054 34683857 LALA0_S01e11518g Lachancea lanzarotensis uncharacterized protein XP_022626709.1 1059657 R 1245769 CDS LALA0_S01e11540g 34683858 1065259..1070466 Unknown 1 NW_019212879.1 similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; uncharacterized protein 1070466 34683858 LALA0_S01e11540g Lachancea lanzarotensis uncharacterized protein XP_022626710.1 1065259 D 1245769 CDS LALA0_S01e11562g 34683859 1070707..1071849 Unknown 1 NW_019212879.1 weakly similar to Lachancea thermotolerans KLTH0D13068g hypothetical protein; uncharacterized protein 1071849 34683859 LALA0_S01e11562g Lachancea lanzarotensis uncharacterized protein XP_022626711.1 1070707 D 1245769 CDS LALA0_S01e11584g 34683860 complement(1071880..1072926) Unknown 1 NW_019212879.1 similar to uniprot|P14908 Saccharomyces cerevisiae YMR228W MTF1 Mitochondrial RNA polymerase specificityfactor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity tobacterial sigma-factors, interacts with mitochondrial corepolymerase Rpo41p; RNA polymerase specificity factor 1072926 34683860 LALA0_S01e11584g Lachancea lanzarotensis RNA polymerase specificity factor XP_022626712.1 1071880 R 1245769 CDS LALA0_S01e11606g 34683861 1073145..1074896 Unknown 1 NW_019212879.1 similar to uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation; TATA-binding protein-associated factor TAF7 1074896 34683861 LALA0_S01e11606g Lachancea lanzarotensis TATA-binding protein-associated factor TAF7 XP_022626713.1 1073145 D 1245769 CDS LALA0_S01e11628g 34683862 complement(1074920..1075480) Unknown 1 NW_019212879.1 similar to uniprot|E4ZYE5 Leptosphaeria maculans LEMA_P113090.1 hypothetical protein; uncharacterized protein 1075480 34683862 LALA0_S01e11628g Lachancea lanzarotensis uncharacterized protein XP_022626714.1 1074920 R 1245769 CDS LALA0_S01e11650g 34683863 join(1075786..1075839,1075940..1080751) Unknown 1 NW_019212879.1 similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p; SWI/SNF catalytic subunit SNF2 1080751 34683863 LALA0_S01e11650g Lachancea lanzarotensis SWI/SNF catalytic subunit SNF2 XP_022626715.1 1075786 D 1245769 CDS LALA0_S01e11672g 34683864 complement(1080788..1081591) Unknown 1 NW_019212879.1 highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; oxidoreductase 1081591 34683864 LALA0_S01e11672g Lachancea lanzarotensis oxidoreductase XP_022626716.1 1080788 R 1245769 CDS LALA0_S01e11738g 34683867 complement(1084458..1085582) Unknown 1 NW_019212879.1 similar to uniprot|P25377 Saccharomyces cerevisiae YCR105W ADH7 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; uncharacterized protein 1085582 34683867 LALA0_S01e11738g Lachancea lanzarotensis uncharacterized protein XP_022626717.1 1084458 R 1245769 CDS LALA0_S01e11760g 34683868 1087719..1090415 Unknown 1 NW_019212879.1 highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; H(+)-exporting P2-type ATPase PMA1 1090415 34683868 LALA0_S01e11760g Lachancea lanzarotensis H(+)-exporting P2-type ATPase PMA1 XP_022626718.1 1087719 D 1245769 CDS LALA0_S01e11804g 34683870 complement(1094832..1096031) Unknown 1 NW_019212879.1 highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; uncharacterized protein 1096031 34683870 LALA0_S01e11804g Lachancea lanzarotensis uncharacterized protein XP_022626719.1 1094832 R 1245769 CDS LALA0_S01e11826g 34683871 1098361..1100541 Unknown 1 NW_019212879.1 similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors; uncharacterized protein 1100541 34683871 LALA0_S01e11826g Lachancea lanzarotensis uncharacterized protein XP_022626720.1 1098361 D 1245769 CDS LALA0_S01e11848g 34683872 complement(1100608..1103313) Unknown 1 NW_019212879.1 weakly similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C (ohnolog of YBL005W) PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; drug-responsive transcription factor PDR1 1103313 34683872 LALA0_S01e11848g Lachancea lanzarotensis drug-responsive transcription factor PDR1 XP_022626721.1 1100608 R 1245769 CDS LALA0_S01e11870g 34683873 1104205..1105605 Unknown 1 NW_019212879.1 highly similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; delta(24(24(1)))-sterol reductase 1105605 34683873 LALA0_S01e11870g Lachancea lanzarotensis delta(24(24(1)))-sterol reductase XP_022626722.1 1104205 D 1245769 CDS LALA0_S01e11892g 34683874 1105868..1106497 Unknown 1 NW_019212879.1 similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions; uncharacterized protein 1106497 34683874 LALA0_S01e11892g Lachancea lanzarotensis uncharacterized protein XP_022626723.1 1105868 D 1245769 CDS LALA0_S01e11914g 34683875 complement(1106709..1107449) Unknown 1 NW_019212879.1 highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; proteasome core particle subunit alpha 1 1107449 34683875 LALA0_S01e11914g Lachancea lanzarotensis proteasome core particle subunit alpha 1 XP_022626724.1 1106709 R 1245769 CDS LALA0_S01e11936g 34683876 1107941..1108453 Unknown 1 NW_019212879.1 similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W Putative protein of unknown function; YGL010W is not an essential gene; uncharacterized protein 1108453 34683876 LALA0_S01e11936g Lachancea lanzarotensis uncharacterized protein XP_022626725.1 1107941 D 1245769 CDS LALA0_S01e11958g 34683877 1109211..1112783 Unknown 1 NW_019212879.1 similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains; cytoskeletal protein-binding protein SLA1 1112783 34683877 LALA0_S01e11958g Lachancea lanzarotensis cytoskeletal protein-binding protein SLA1 XP_022626726.1 1109211 D 1245769 CDS LALA0_S01e11980g 34683878 complement(1112999..1115347) Unknown 1 NW_019212879.1 highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway; 3-isopropylmalate dehydratase LEU1 1115347 34683878 LALA0_S01e11980g Lachancea lanzarotensis 3-isopropylmalate dehydratase LEU1 XP_022626727.1 1112999 R 1245769 CDS LALA0_S01e12002g 34683879 complement(join(1115879..1118409,1118490..1118526)) Unknown 1 NW_019212879.1 similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; uncharacterized protein 1118526 34683879 LALA0_S01e12002g Lachancea lanzarotensis uncharacterized protein XP_022626728.1 1115879 R 1245769 CDS LALA0_S01e12024g 34683880 complement(join(1119542..1122697,1122773..1122799)) Unknown 1 NW_019212879.1 similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; uncharacterized protein 1122799 34683880 LALA0_S01e12024g Lachancea lanzarotensis uncharacterized protein XP_022626729.1 1119542 R 1245769 CDS LALA0_S01e12046g 34683881 complement(1123156..1124799) Unknown 1 NW_019212879.1 similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; arginyltransferase 1124799 34683881 LALA0_S01e12046g Lachancea lanzarotensis arginyltransferase XP_022626730.1 1123156 R 1245769 CDS LALA0_S01e12068g 34683882 1126058..1126618 Unknown 1 NW_019212879.1 similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix; J-type chaperone JAC1 1126618 34683882 LALA0_S01e12068g Lachancea lanzarotensis J-type chaperone JAC1 XP_022626731.1 1126058 D 1245769 CDS LALA0_S01e12090g 34683883 complement(1126811..1127563) Unknown 1 NW_019212879.1 highly similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; casein kinase 2 regulatory subunit CKB1 1127563 34683883 LALA0_S01e12090g Lachancea lanzarotensis casein kinase 2 regulatory subunit CKB1 XP_022626732.1 1126811 R 1245769 CDS LALA0_S01e12112g 34683884 1128182..1128769 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53192 Saccharomyces cerevisiae YGL020C GET1 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; GET complex subunit GET1 1128769 34683884 LALA0_S01e12112g Lachancea lanzarotensis GET complex subunit GET1 XP_022626733.1 1128182 D 1245769 CDS LALA0_S01e12134g 34683885 complement(1129126..1131060) Unknown 1 NW_019212879.1 weakly similar to uniprot|P43633 Saccharomyces cerevisiae YGL021W (ohnolog of YBL009W) ALK1 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins; protein kinase ALK1 1131060 34683885 LALA0_S01e12134g Lachancea lanzarotensis protein kinase ALK1 XP_022626734.1 1129126 R 1245769 CDS LALA0_S01e12156g 34683886 1132018..1132872 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles; uncharacterized protein 1132872 34683886 LALA0_S01e12156g Lachancea lanzarotensis uncharacterized protein XP_022626735.1 1132018 D 1245769 CDS LALA0_S01e12178g 34683887 complement(1132994..1135171) Unknown 1 NW_019212879.1 highly similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 1135171 34683887 LALA0_S01e12178g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 XP_022626736.1 1132994 R 1245769 CDS LALA0_S01e12200g 34683888 1136783..1138444 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C PIB2 Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27; uncharacterized protein 1138444 34683888 LALA0_S01e12200g Lachancea lanzarotensis uncharacterized protein XP_022626737.1 1136783 D 1245769 CDS LALA0_S01e12222g 34683889 complement(1138678..1140786) Unknown 1 NW_019212879.1 similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 1140786 34683889 LALA0_S01e12222g Lachancea lanzarotensis bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 XP_022626738.1 1138678 R 1245769 CDS LALA0_S01e12266g 34683891 complement(1141378..1142517) Unknown 1 NW_019212879.1 similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate; methionyl-tRNA formyltransferase 1142517 34683891 LALA0_S01e12266g Lachancea lanzarotensis methionyl-tRNA formyltransferase XP_022626739.1 1141378 R 1245769 CDS LALA0_S01e12288g 34683892 1143054..1144142 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor; uncharacterized protein 1144142 34683892 LALA0_S01e12288g Lachancea lanzarotensis uncharacterized protein XP_022626740.1 1143054 D 1245769 CDS LALA0_S01e12310g 34683893 1144719..1146848 Unknown 1 NW_019212879.1 highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; tryptophan synthase TRP5 1146848 34683893 LALA0_S01e12310g Lachancea lanzarotensis tryptophan synthase TRP5 XP_022626741.1 1144719 D 1245769 CDS LALA0_S01e12332g 34683894 1147174..1149864 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; uncharacterized protein 1149864 34683894 LALA0_S01e12332g Lachancea lanzarotensis uncharacterized protein XP_022626742.1 1147174 D 1245769 CDS LALA0_S01e12354g 34683895 1150227..1152644 Unknown 1 NW_019212879.1 similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; mannosyl-oligosaccharide glucosidase 1152644 34683895 LALA0_S01e12354g Lachancea lanzarotensis mannosyl-oligosaccharide glucosidase XP_022626743.1 1150227 D 1245769 CDS LALA0_S01e12376g 34683896 1153458..1155080 Unknown 1 NW_019212879.1 similar to uniprot|P53189 Saccharomyces cerevisiae YGL028C SCW11 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; uncharacterized protein 1155080 34683896 LALA0_S01e12376g Lachancea lanzarotensis uncharacterized protein XP_022626744.1 1153458 D 1245769 CDS LALA0_S01e12398g 34683897 complement(1155249..1156244) Unknown 1 NW_019212879.1 highly similar to uniprot|C5DHU1 Lachancea thermotolerans KLTH0E07106g hypothetical protein; uncharacterized protein 1156244 34683897 LALA0_S01e12398g Lachancea lanzarotensis uncharacterized protein XP_022626745.1 1155249 R 1245769 CDS LALA0_S01e12442g 34683899 complement(1156953..1157360) Unknown 1 NW_019212879.1 similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; uncharacterized protein 1157360 34683899 LALA0_S01e12442g Lachancea lanzarotensis uncharacterized protein XP_022626746.1 1156953 R 1245769 CDS LALA0_S01e12464g 34683900 1157645..1160227 Unknown 1 NW_019212879.1 similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C CCM1 Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport; uncharacterized protein 1160227 34683900 LALA0_S01e12464g Lachancea lanzarotensis uncharacterized protein XP_022626747.1 1157645 D 1245769 CDS LALA0_S01e12486g 34683901 complement(1160350..1161561) Unknown 1 NW_019212879.1 similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Putative protein of unknown function; predicted to be an integal membrane protein; glycerophosphocholine acyltransferase 1161561 34683901 LALA0_S01e12486g Lachancea lanzarotensis glycerophosphocholine acyltransferase XP_022626748.1 1160350 R 1245769 CDS LALA0_S01e12508g 34683902 1163694..1165097 Unknown 1 NW_019212879.1 weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; uncharacterized protein 1165097 34683902 LALA0_S01e12508g Lachancea lanzarotensis uncharacterized protein XP_022626749.1 1163694 D 1245769 CDS LALA0_S01e12530g 34683903 1169163..1171295 Unknown 1 NW_019212879.1 similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; serine/threonine protein kinase KNS1 1171295 34683903 LALA0_S01e12530g Lachancea lanzarotensis serine/threonine protein kinase KNS1 XP_022626750.1 1169163 D 1245769 CDS LALA0_S01e12552g 34683904 complement(1171613..1172716) Unknown 1 NW_019212879.1 weakly similar to Lachancea thermotolerans KLTH0E06666g hypothetical protein; uncharacterized protein 1172716 34683904 LALA0_S01e12552g Lachancea lanzarotensis uncharacterized protein XP_022626751.1 1171613 R 1245769 CDS LALA0_S01e12574g 34683905 complement(1173226..1174647) Unknown 1 NW_019212879.1 similar to uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes; FG-nucleoporin NUP49 1174647 34683905 LALA0_S01e12574g Lachancea lanzarotensis FG-nucleoporin NUP49 XP_022626752.1 1173226 R 1245769 CDS LALA0_S01e12596g 34683906 1175183..1179691 Unknown 1 NW_019212879.1 similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; chromatin-binding exonuclease XRN1 1179691 34683906 LALA0_S01e12596g Lachancea lanzarotensis chromatin-binding exonuclease XRN1 XP_022626753.1 1175183 D 1245769 CDS LALA0_S01e12618g 34683907 complement(1179865..1180704) Unknown 1 NW_019212879.1 similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 1180704 34683907 LALA0_S01e12618g Lachancea lanzarotensis uncharacterized protein XP_022626754.1 1179865 R 1245769 CDS LALA0_S01e12640g 34683908 1180885..1182084 Unknown 1 NW_019212879.1 weakly similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents; ssDNA endodeoxyribonuclease SAE2 1182084 34683908 LALA0_S01e12640g Lachancea lanzarotensis ssDNA endodeoxyribonuclease SAE2 XP_022626755.1 1180885 D 1245769 CDS LALA0_S01e12662g 34683909 complement(1182176..1184812) Unknown 1 NW_019212879.1 similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; citrin 1184812 34683909 LALA0_S01e12662g Lachancea lanzarotensis citrin XP_022626756.1 1182176 R 1245769 CDS LALA0_S01e12684g 34683910 complement(1185536..1186465) Unknown 1 NW_019212879.1 similar to uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition; uncharacterized protein 1186465 34683910 LALA0_S01e12684g Lachancea lanzarotensis uncharacterized protein XP_022626757.1 1185536 R 1245769 CDS LALA0_S01e12706g 34683911 1186910..1188181 Unknown 1 NW_019212879.1 similar to uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 Palmitoylated, vacuolar membrane-localizedcasein kinase I isoform; negatively regulates vacuolefusion during hypertonic stress via phosphorylation ofVps41p; shares essential functions with Hrr25p; regulatesvesicle fusion in AP-3 pathway; casein kinase YCK3 1188181 34683911 LALA0_S01e12706g Lachancea lanzarotensis casein kinase YCK3 XP_022626758.1 1186910 D 1245769 CDS LALA0_S01e12728g 34683912 complement(1188371..1190026) Unknown 1 NW_019212879.1 similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; uncharacterized protein 1190026 34683912 LALA0_S01e12728g Lachancea lanzarotensis uncharacterized protein XP_022626759.1 1188371 R 1245769 CDS LALA0_S01e12750g 34683913 1191556..1193982 Unknown 1 NW_019212879.1 highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; NEDD4 family E3 ubiquitin-protein ligase 1193982 34683913 LALA0_S01e12750g Lachancea lanzarotensis NEDD4 family E3 ubiquitin-protein ligase XP_022626760.1 1191556 D 1245769 CDS LALA0_S01e12772g 34683914 1194212..1195720 Unknown 1 NW_019212879.1 weakly similar to uniprot|P46945 Saccharomyces cerevisiae YGL176C Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype; uncharacterized protein 1195720 34683914 LALA0_S01e12772g Lachancea lanzarotensis uncharacterized protein XP_022626761.1 1194212 D 1245769 CDS LALA0_S01e12794g 34683915 complement(1196173..1198167) Unknown 1 NW_019212879.1 similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest; uncharacterized protein 1198167 34683915 LALA0_S01e12794g Lachancea lanzarotensis uncharacterized protein XP_022626762.1 1196173 R 1245769 CDS LALA0_S01e12816g 34683916 complement(1199712..1200497) Unknown 1 NW_019212879.1 highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA; rRNA-processing protein NSA2 1200497 34683916 LALA0_S01e12816g Lachancea lanzarotensis rRNA-processing protein NSA2 XP_022626763.1 1199712 R 1245769 CDS LALA0_S01e12838g 34683917 1200839..1201933 Unknown 1 NW_019212879.1 similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus; uncharacterized protein 1201933 34683917 LALA0_S01e12838g Lachancea lanzarotensis uncharacterized protein XP_022626764.1 1200839 D 1245769 CDS LALA0_S01e12860g 34683918 1202091..1202681 Unknown 1 NW_019212879.1 similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology; uncharacterized protein 1202681 34683918 LALA0_S01e12860g Lachancea lanzarotensis uncharacterized protein XP_022626765.1 1202091 D 1245769 CDS LALA0_S01e12882g 34683919 1203111..1206482 Unknown 1 NW_019212879.1 weakly similar to uniprot|P43637 Saccharomyces cerevisiae YGL179C (ohnolog of YER129W) TOS3 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; uncharacterized protein 1206482 34683919 LALA0_S01e12882g Lachancea lanzarotensis uncharacterized protein XP_022626766.1 1203111 D 1245769 CDS LALA0_S01e12904g 34683920 complement(1206753..1209371) Unknown 1 NW_019212879.1 similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; serine/threonine protein kinase ATG1 1209371 34683920 LALA0_S01e12904g Lachancea lanzarotensis serine/threonine protein kinase ATG1 XP_022626767.1 1206753 R 1245769 CDS LALA0_S01e12926g 34683921 complement(1210014..1211096) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations; uncharacterized protein 1211096 34683921 LALA0_S01e12926g Lachancea lanzarotensis uncharacterized protein XP_022626768.1 1210014 R 1245769 CDS LALA0_S01e12948g 34683922 join(1212520..1212522,1212590..1213261) Unknown 1 NW_019212879.1 similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks; uncharacterized protein 1213261 34683922 LALA0_S01e12948g Lachancea lanzarotensis uncharacterized protein XP_022626769.1 1212520 D 1245769 CDS LALA0_S01e12970g 34683923 complement(1213456..1214748) Unknown 1 NW_019212879.1 weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress; uncharacterized protein 1214748 34683923 LALA0_S01e12970g Lachancea lanzarotensis uncharacterized protein XP_022626770.1 1213456 R 1245769 CDS LALA0_S01e12992g 34683924 complement(1215282..1218110) Unknown 1 NW_019212879.1 similar to uniprot|Q754A2 Ashbya gossypii AFR170Cp hypothetical protein; uncharacterized protein 1218110 34683924 LALA0_S01e12992g Lachancea lanzarotensis uncharacterized protein XP_022626771.1 1215282 R 1245769 CDS LALA0_S01e13014g 34683925 1220531..1221913 Unknown 1 NW_019212879.1 similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p; cystathionine beta-lyase STR3 1221913 34683925 LALA0_S01e13014g Lachancea lanzarotensis cystathionine beta-lyase STR3 XP_022626772.1 1220531 D 1245769 CDS LALA0_S01e13036g 34683926 1222312..1223412 Unknown 1 NW_019212879.1 similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 1223412 34683926 LALA0_S01e13036g Lachancea lanzarotensis uncharacterized protein XP_022626773.1 1222312 D 1245769 CDS LALA0_S01e13058g 34683927 1223811..1225508 Unknown 1 NW_019212879.1 similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p; uncharacterized protein 1225508 34683927 LALA0_S01e13058g Lachancea lanzarotensis uncharacterized protein XP_022626774.1 1223811 D 1245769 CDS LALA0_S01e13080g 34683928 1226206..1226694 Unknown 1 NW_019212879.1 highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation; cytochrome c oxidase subunit IV 1226694 34683928 LALA0_S01e13080g Lachancea lanzarotensis cytochrome c oxidase subunit IV XP_022626775.1 1226206 D 1245769 CDS LALA0_S01e13102g 34683929 1227860..1228222 Unknown 1 NW_019212879.1 highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C (ohnolog of YER131W) RPS26A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein; 40S ribosomal protein eS26 1228222 34683929 LALA0_S01e13102g Lachancea lanzarotensis 40S ribosomal protein eS26 XP_022626776.1 1227860 D 1245769 CDS LALA0_S01e13124g 34683930 1229307..1230737 Unknown 1 NW_019212879.1 similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); involved in regulation of mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains sequestration of the phosphatase Cdc14p in nucleolus during early meiosis, which is essential for meiosis I spindle assembly; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; found in nucleus, bud neck and bud of most cells; protein phosphatase 2A regulatory subunit CDC55 1230737 34683930 LALA0_S01e13124g Lachancea lanzarotensis protein phosphatase 2A regulatory subunit CDC55 XP_022626777.1 1229307 D 1245769 CDS LALA0_S01e13146g 34683931 complement(1231209..1231592) Unknown 1 NW_019212879.1 highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; cytochrome c oxidase subunit VIa 1231592 34683931 LALA0_S01e13146g Lachancea lanzarotensis cytochrome c oxidase subunit VIa XP_022626778.1 1231209 R 1245769 CDS LALA0_S01e13190g 34683933 complement(1233011..1234567) Unknown 1 NW_019212879.1 similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids; mRNA (N6-adenosine)-methyltransferase 1234567 34683933 LALA0_S01e13190g Lachancea lanzarotensis mRNA (N6-adenosine)-methyltransferase XP_022626779.1 1233011 R 1245769 CDS LALA0_S01e13212g 34683934 1236195..1237544 Unknown 1 NW_019212879.1 highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; histone deacetylase HOS2 1237544 34683934 LALA0_S01e13212g Lachancea lanzarotensis histone deacetylase HOS2 XP_022626780.1 1236195 D 1245769 CDS LALA0_S01e13234g 34683935 1237937..1238161 Unknown 1 NW_019212879.1 similar to uniprot|C5DHM3 Lachancea thermotolerans KLTH0E05522g hypothetical protein; uncharacterized protein 1238161 34683935 LALA0_S01e13234g Lachancea lanzarotensis uncharacterized protein XP_022626781.1 1237937 D 1245769 CDS LALA0_S01e13256g 34683936 complement(1238207..1246255) Unknown 1 NW_019212879.1 similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; uncharacterized protein 1246255 34683936 LALA0_S01e13256g Lachancea lanzarotensis uncharacterized protein XP_022626782.1 1238207 R 1245769 CDS LALA0_S01e13278g 34683937 complement(1246759..1251633) Unknown 1 NW_019212879.1 weakly similar to uniprot|P53094 Saccharomyces cerevisiae YGL197W (ohnolog of YER132C) MDS3 Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; uncharacterized protein 1251633 34683937 LALA0_S01e13278g Lachancea lanzarotensis uncharacterized protein XP_022626783.1 1246759 R 1245769 CDS LALA0_S01e13300g 34683938 complement(1251949..1252656) Unknown 1 NW_019212879.1 similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; uncharacterized protein 1252656 34683938 LALA0_S01e13300g Lachancea lanzarotensis uncharacterized protein XP_022626784.1 1251949 R 1245769 CDS LALA0_S01e13322g 34683939 join(1255235..1255411,1256316..1257074) Unknown 1 NW_019212879.1 highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 1257074 34683939 LALA0_S01e13322g Lachancea lanzarotensis type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 XP_022626785.1 1255235 D 1245769 CDS LALA0_S01e13344g 34683940 1258393..1259001 Unknown 1 NW_019212879.1 highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles; uncharacterized protein 1259001 34683940 LALA0_S01e13344g Lachancea lanzarotensis uncharacterized protein XP_022626786.1 1258393 D 1245769 CDS LALA0_S01e13388g 34683942 1259392..1261986 Unknown 1 NW_019212879.1 similar to uniprot|P38742 Saccharomyces cerevisiae YHL023C NPR3 Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; null mutant displays delayed meiotic DNA replication and double-strand break repair; uncharacterized protein 1261986 34683942 LALA0_S01e13388g Lachancea lanzarotensis uncharacterized protein XP_022626787.1 1259392 D 1245769 CDS LALA0_S01e13410g 34683943 complement(1262280..1264496) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes; uncharacterized protein 1264496 34683943 LALA0_S01e13410g Lachancea lanzarotensis uncharacterized protein XP_022626788.1 1262280 R 1245769 CDS LALA0_S01e13432g 34683944 complement(1266287..1267378) Unknown 1 NW_019212879.1 similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W ECM4 Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; S-glutathionyl-(chloro)hydroquinone reductase 1267378 34683944 LALA0_S01e13432g Lachancea lanzarotensis S-glutathionyl-(chloro)hydroquinone reductase XP_022626789.1 1266287 R 1245769 CDS LALA0_S01e13454g 34683945 complement(1268615..1271326) Unknown 1 NW_019212879.1 highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; chaperone ATPase HSP104 1271326 34683945 LALA0_S01e13454g Lachancea lanzarotensis chaperone ATPase HSP104 XP_022626790.1 1268615 R 1245769 CDS LALA0_S01e13476g 34683946 complement(1272363..1273151) Unknown 1 NW_019212879.1 similar to uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; Fe-binding Fe/S cluster assembly protein ISA1 1273151 34683946 LALA0_S01e13476g Lachancea lanzarotensis Fe-binding Fe/S cluster assembly protein ISA1 XP_022626791.1 1272363 R 1245769 CDS LALA0_S01e13498g 34683947 complement(1273999..1276164) Unknown 1 NW_019212879.1 similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W FRA1 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; aminopeptidase P 1276164 34683947 LALA0_S01e13498g Lachancea lanzarotensis aminopeptidase P XP_022626792.1 1273999 R 1245769 CDS LALA0_S01e13520g 34683948 complement(1277156..1278838) Unknown 1 NW_019212879.1 similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane; polyamine transporter TPO1 1278838 34683948 LALA0_S01e13520g Lachancea lanzarotensis polyamine transporter TPO1 XP_022626793.1 1277156 R 1245769 CDS LALA0_S01e13542g 34683949 1280537..1283569 Unknown 1 NW_019212879.1 similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C GPI13 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein; mannose-ethanolamine phosphotransferase GPI13 1283569 34683949 LALA0_S01e13542g Lachancea lanzarotensis mannose-ethanolamine phosphotransferase GPI13 XP_022626794.1 1280537 D 1245769 CDS LALA0_S01e13564g 34683950 complement(1283650..1284594) Unknown 1 NW_019212879.1 weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; uncharacterized protein 1284594 34683950 LALA0_S01e13564g Lachancea lanzarotensis uncharacterized protein XP_022626795.1 1283650 R 1245769 CDS LALA0_S01e13586g 34683951 1285286..1287337 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene; uncharacterized protein 1287337 34683951 LALA0_S01e13586g Lachancea lanzarotensis uncharacterized protein XP_022626796.1 1285286 D 1245769 CDS LALA0_S01e13608g 34683952 complement(1287372..1287986) Unknown 1 NW_019212879.1 similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W IRC19 Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci; uncharacterized protein 1287986 34683952 LALA0_S01e13608g Lachancea lanzarotensis uncharacterized protein XP_022626797.1 1287372 R 1245769 CDS LALA0_S01e13630g 34683953 1288244..1290703 Unknown 1 NW_019212879.1 highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions; uncharacterized protein 1290703 34683953 LALA0_S01e13630g Lachancea lanzarotensis uncharacterized protein XP_022626798.1 1288244 D 1245769 CDS LALA0_S01e13652g 34683954 complement(join(1290760..1292702,1292799..1292808)) Unknown 1 NW_019212879.1 similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated; polynucleotide 5'-hydroxyl-kinase 1292808 34683954 LALA0_S01e13652g Lachancea lanzarotensis polynucleotide 5'-hydroxyl-kinase XP_022626799.1 1290760 R 1245769 CDS LALA0_S01e13674g 34683955 complement(1293063..1294409) Unknown 1 NW_019212879.1 weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W RIM101 Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC; alkaline-responsive transcriptional regulator RIM101 1294409 34683955 LALA0_S01e13674g Lachancea lanzarotensis alkaline-responsive transcriptional regulator RIM101 XP_022626800.1 1293063 R 1245769 CDS LALA0_S01e13696g 34683956 complement(1294923..1296422) Unknown 1 NW_019212879.1 similar to uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3; uncharacterized protein 1296422 34683956 LALA0_S01e13696g Lachancea lanzarotensis uncharacterized protein XP_022626801.1 1294923 R 1245769 CDS LALA0_S01e13718g 34683957 1298206..1299903 Unknown 1 NW_019212879.1 similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C OCA5 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 1299903 34683957 LALA0_S01e13718g Lachancea lanzarotensis uncharacterized protein XP_022626802.1 1298206 D 1245769 CDS LALA0_S01e13740g 34683958 join(1300164..1300176,1300242..1301764) Unknown 1 NW_019212879.1 weakly similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; E3 ubiquitin-protein ligase PRP19 1301764 34683958 LALA0_S01e13740g Lachancea lanzarotensis E3 ubiquitin-protein ligase PRP19 XP_022626803.1 1300164 D 1245769 CDS LALA0_S01e13762g 34683959 1302636..1303406 Unknown 1 NW_019212879.1 similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome; uncharacterized protein 1303406 34683959 LALA0_S01e13762g Lachancea lanzarotensis uncharacterized protein XP_022626804.1 1302636 D 1245769 CDS LALA0_S01e13784g 34683960 1304354..1305043 Unknown 1 NW_019212879.1 some similarities with uniprot|P04838 Saccharomyces cerevisiae YLL039C UBI4 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; ubiquitin 1305043 34683960 LALA0_S01e13784g Lachancea lanzarotensis ubiquitin XP_022626805.1 1304354 D 1245769 CDS LALA0_S01e13806g 34683961 complement(1305118..1310652) Unknown 1 NW_019212879.1 similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Scaffold protein that assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; uncharacterized protein 1310652 34683961 LALA0_S01e13806g Lachancea lanzarotensis uncharacterized protein XP_022626806.1 1305118 R 1245769 CDS LALA0_S01e13828g 34683962 1311004..1320315 Unknown 1 NW_019212879.1 similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention; membrane morphogenesis protein VPS13 1320315 34683962 LALA0_S01e13828g Lachancea lanzarotensis membrane morphogenesis protein VPS13 XP_022626807.1 1311004 D 1245769 CDS LALA0_S01e13850g 34683963 1322333..1323127 Unknown 1 NW_019212879.1 highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; succinate dehydrogenase iron-sulfur protein subunit SDH2 1323127 34683963 LALA0_S01e13850g Lachancea lanzarotensis succinate dehydrogenase iron-sulfur protein subunit SDH2 XP_022626808.1 1322333 D 1245769 CDS LALA0_S01e13872g 34683964 1323437..1323925 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy; E2-like conjugating enzyme 1323925 34683964 LALA0_S01e13872g Lachancea lanzarotensis E2-like conjugating enzyme XP_022626809.1 1323437 D 1245769 CDS LALA0_S01e13894g 34683965 1324045..1324689 Unknown 1 NW_019212879.1 similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28; uncharacterized protein 1324689 34683965 LALA0_S01e13894g Lachancea lanzarotensis uncharacterized protein XP_022626810.1 1324045 D 1245769 CDS LALA0_S01e13916g 34683966 complement(1324764..1326695) Unknown 1 NW_019212879.1 similar to uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress; uncharacterized protein 1326695 34683966 LALA0_S01e13916g Lachancea lanzarotensis uncharacterized protein XP_022626811.1 1324764 R 1245769 CDS LALA0_S01e13938g 34683967 1327750..1328508 Unknown 1 NW_019212879.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 1328508 34683967 LALA0_S01e13938g Lachancea lanzarotensis uncharacterized protein XP_022626812.1 1327750 D 1245769 CDS LALA0_S01e13960g 34683968 1330361..1332424 Unknown 1 NW_019212879.1 similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; glycerol kinase 1332424 34683968 LALA0_S01e13960g Lachancea lanzarotensis glycerol kinase XP_022626813.1 1330361 D 1245769 CDS LALA0_S01e13982g 34683969 1333136..1333906 Unknown 1 NW_019212879.1 highly similar to uniprot|P17076 Saccharomyces cerevisiae YHL033C (ohnolog of YLL045C) RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits; 60S ribosomal protein eL8 1333906 34683969 LALA0_S01e13982g Lachancea lanzarotensis 60S ribosomal protein eL8 XP_022626814.1 1333136 D 1245769 CDS LALA0_S01e14004g 34683970 1334769..1335434 Unknown 1 NW_019212879.1 similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins; CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1335434 34683970 LALA0_S01e14004g Lachancea lanzarotensis CDP-diacylglycerol--inositol 3-phosphatidyltransferase XP_022626815.1 1334769 D 1245769 CDS LALA0_S01e14026g 34683971 complement(1335893..1336834) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcohol dehydrogenase isoenzyme V; involved in ethanol production; uncharacterized protein 1336834 34683971 LALA0_S01e14026g Lachancea lanzarotensis uncharacterized protein XP_022626816.1 1335893 R 1245769 CDS LALA0_S01e14048g 34683972 1337395..1338909 Unknown 1 NW_019212879.1 similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; uncharacterized protein 1338909 34683972 LALA0_S01e14048g Lachancea lanzarotensis uncharacterized protein XP_022626817.1 1337395 D 1245769 CDS LALA0_S01e14070g 34683973 1340245..1341906 Unknown 1 NW_019212879.1 weakly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock; uncharacterized protein 1341906 34683973 LALA0_S01e14070g Lachancea lanzarotensis uncharacterized protein XP_022626818.1 1340245 D 1245769 CDS LALA0_S01e14092g 34683974 1343218..1344273 Unknown 1 NW_019212879.1 highly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcoholdehydrogenase isoenzyme V; involved in ethanol production; uncharacterized protein 1344273 34683974 LALA0_S01e14092g Lachancea lanzarotensis uncharacterized protein XP_022626819.1 1343218 D 1245769 CDS LALA0_S01e14114g 34683975 1345018..1345953 Unknown 1 NW_019212879.1 similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Putative protein of unknown function; uncharacterized protein 1345953 34683975 LALA0_S01e14114g Lachancea lanzarotensis uncharacterized protein XP_022626820.1 1345018 D 1245769 CDS LALA0_S01e14136g 34683976 1346873..1349938 Unknown 1 NW_019212879.1 similar to uniprot|P48361 Saccharomyces cerevisiae YGR097W (ohnolog of YPR115W) ASK10 Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p; uncharacterized protein 1349938 34683976 LALA0_S01e14136g Lachancea lanzarotensis uncharacterized protein XP_022626821.1 1346873 D 1245769 CDS LALA0_S01e14158g 34683977 complement(1350102..1350740) Unknown 1 NW_019212879.1 highly similar to uniprot|Q0UMW8 Phaeosphaeria nodorum SNOG_06896 hypothetical protein; uncharacterized protein 1350740 34683977 LALA0_S01e14158g Lachancea lanzarotensis uncharacterized protein XP_022626822.1 1350102 R 1245769 CDS LALA0_S01e14180g 34683978 1351173..1351985 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W RRG8 Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; uncharacterized protein 1351985 34683978 LALA0_S01e14180g Lachancea lanzarotensis uncharacterized protein XP_022626823.1 1351173 D 1245769 CDS LALA0_S01e14202g 34683979 complement(1352004..1356827) Unknown 1 NW_019212879.1 similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; separase 1356827 34683979 LALA0_S01e14202g Lachancea lanzarotensis separase XP_022626824.1 1352004 R 1245769 CDS LALA0_S01e14224g 34683980 1357000..1359060 Unknown 1 NW_019212879.1 similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; uncharacterized protein 1359060 34683980 LALA0_S01e14224g Lachancea lanzarotensis uncharacterized protein XP_022626825.1 1357000 D 1245769 CDS LALA0_S01e14246g 34683981 1359577..1366857 Unknown 1 NW_019212879.1 similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Putative protein of unknown function; uncharacterized protein 1366857 34683981 LALA0_S01e14246g Lachancea lanzarotensis uncharacterized protein XP_022626826.1 1359577 D 1245769 CDS LALA0_S01e14268g 34683982 1367690..1370527 Unknown 1 NW_019212879.1 similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function; GTPase-activating protein MDR1 1370527 34683982 LALA0_S01e14268g Lachancea lanzarotensis GTPase-activating protein MDR1 XP_022626827.1 1367690 D 1245769 CDS LALA0_S01e14290g 34683983 1370827..1371846 Unknown 1 NW_019212879.1 similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases; rhomboid protease PCP1 1371846 34683983 LALA0_S01e14290g Lachancea lanzarotensis rhomboid protease PCP1 XP_022626828.1 1370827 D 1245769 CDS LALA0_S01e14312g 34683984 complement(1372248..1372739) Unknown 1 NW_019212879.1 similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria; glutamyl-tRNA(Gln) amidotransferase subunit F 1372739 34683984 LALA0_S01e14312g Lachancea lanzarotensis glutamyl-tRNA(Gln) amidotransferase subunit F XP_022626829.1 1372248 R 1245769 CDS LALA0_S01e14334g 34683985 1373960..1375759 Unknown 1 NW_019212879.1 highly similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation; mRNA-binding ribosome synthesis protein NOP7 1375759 34683985 LALA0_S01e14334g Lachancea lanzarotensis mRNA-binding ribosome synthesis protein NOP7 XP_022626830.1 1373960 D 1245769 CDS LALA0_S01e14356g 34683986 complement(1375886..1376701) Unknown 1 NW_019212879.1 similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance; uncharacterized protein 1376701 34683986 LALA0_S01e14356g Lachancea lanzarotensis uncharacterized protein XP_022626831.1 1375886 R 1245769 CDS LALA0_S01e14378g 34683987 join(1376854..1376873,1376969..1377194) Unknown 1 NW_019212879.1 similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER); uncharacterized protein 1377194 34683987 LALA0_S01e14378g Lachancea lanzarotensis uncharacterized protein XP_022626832.1 1376854 D 1245769 CDS LALA0_S01e14400g 34683988 complement(1377363..1378136) Unknown 1 NW_019212879.1 similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C VOA1 Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval; uncharacterized protein 1378136 34683988 LALA0_S01e14400g Lachancea lanzarotensis uncharacterized protein XP_022626833.1 1377363 R 1245769 CDS LALA0_S01e14444g 34683990 1379219..1380469 Unknown 1 NW_019212879.1 similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W MRI1 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; S-methyl-5-thioribose-1-phosphate isomerase MRI1 1380469 34683990 LALA0_S01e14444g Lachancea lanzarotensis S-methyl-5-thioribose-1-phosphate isomerase MRI1 XP_022626834.1 1379219 D 1245769 CDS LALA0_S01e14466g 34683991 1381798..1383120 Unknown 1 NW_019212879.1 similar to uniprot|C5DHI4 Lachancea thermotolerans KLTH0E04576g hypothetical protein; uncharacterized protein 1383120 34683991 LALA0_S01e14466g Lachancea lanzarotensis uncharacterized protein XP_022626835.1 1381798 D 1245769 CDS LALA0_S01e14510g 34683993 1385038..1386537 Unknown 1 NW_019212879.1 similar to uniprot|P24868 Saccharomyces cerevisiae YGR108W (ohnolog of YPR119W) CLB1 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; uncharacterized protein 1386537 34683993 LALA0_S01e14510g Lachancea lanzarotensis uncharacterized protein XP_022626836.1 1385038 D 1245769 CDS LALA0_S01e14532g 34683994 complement(1386978..1388213) Unknown 1 NW_019212879.1 similar to uniprot|P32943 Saccharomyces cerevisiae YGR109C (ohnolog of YPR120C) CLB6 B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; uncharacterized protein 1388213 34683994 LALA0_S01e14532g Lachancea lanzarotensis uncharacterized protein XP_022626837.1 1386978 R 1245769 CDS LALA0_S01e14576g 34683996 1390358..1393912 Unknown 1 NW_019212879.1 similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells; uncharacterized protein 1393912 34683996 LALA0_S01e14576g Lachancea lanzarotensis uncharacterized protein XP_022626838.1 1390358 D 1245769 CDS LALA0_S01e14598g 34683997 1394193..1395398 Unknown 1 NW_019212879.1 similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 1395398 34683997 LALA0_S01e14598g Lachancea lanzarotensis uncharacterized protein XP_022626839.1 1394193 D 1245769 CDS LALA0_S01e14642g 34683999 1395933..1396403 Unknown 1 NW_019212879.1 highly similar to uniprot|P33317 Saccharomyces cerevisiae YBR252W DUT1 deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; bifunctional dITP/dUTP diphosphatase 1396403 34683999 LALA0_S01e14642g Lachancea lanzarotensis bifunctional dITP/dUTP diphosphatase XP_022626840.1 1395933 D 1245769 CDS LALA0_S01e14664g 34684000 1396600..1396962 Unknown 1 NW_019212879.1 similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; uncharacterized protein 1396962 34684000 LALA0_S01e14664g Lachancea lanzarotensis uncharacterized protein XP_022626841.1 1396600 D 1245769 CDS LALA0_S01e14686g 34684001 1397356..1399014 Unknown 1 NW_019212879.1 similar to uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation; MIND complex subunit DSN1 1399014 34684001 LALA0_S01e14686g Lachancea lanzarotensis MIND complex subunit DSN1 XP_022626842.1 1397356 D 1245769 CDS LALA0_S01e14708g 34684002 complement(1399174..1399686) Unknown 1 NW_019212879.1 similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder; TRAPP subunit TRS20 1399686 34684002 LALA0_S01e14708g Lachancea lanzarotensis TRAPP subunit TRS20 XP_022626843.1 1399174 R 1245769 CDS LALA0_S01e14730g 34684003 1400622..1402205 Unknown 1 NW_019212879.1 weakly similar to uniprot|P38335 Saccharomyces cerevisiae YBR255W MTC4 Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1; uncharacterized protein 1402205 34684003 LALA0_S01e14730g Lachancea lanzarotensis uncharacterized protein XP_022626844.1 1400622 D 1245769 CDS LALA0_S01e14752g 34684004 complement(join(1402278..1402574,1402691..1402750)) Unknown 1 NW_019212879.1 highly similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species; uncharacterized protein 1402750 34684004 LALA0_S01e14752g Lachancea lanzarotensis uncharacterized protein XP_022626845.1 1402278 R 1245769 CDS LALA0_S01e14774g 34684005 complement(1403870..1404781) Unknown 1 NW_019212879.1 similar to uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation; uncharacterized protein 1404781 34684005 LALA0_S01e14774g Lachancea lanzarotensis uncharacterized protein XP_022626846.1 1403870 R 1245769 CDS LALA0_S01e14796g 34684006 1405758..1407074 Unknown 1 NW_019212879.1 similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; uncharacterized protein 1407074 34684006 LALA0_S01e14796g Lachancea lanzarotensis uncharacterized protein XP_022626847.1 1405758 D 1245769 CDS LALA0_S01e14818g 34684007 complement(1407190..1407891) Unknown 1 NW_019212879.1 highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; riboflavin synthase 1407891 34684007 LALA0_S01e14818g Lachancea lanzarotensis riboflavin synthase XP_022626848.1 1407190 R 1245769 CDS LALA0_S01e14840g 34684008 complement(1408287..1408850) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40548 Saccharomyces cerevisiae YIL016W SNL1 Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein; uncharacterized protein 1408850 34684008 LALA0_S01e14840g Lachancea lanzarotensis uncharacterized protein XP_022626849.1 1408287 R 1245769 CDS LALA0_S01e14862g 34684009 1410056..1412995 Unknown 1 NW_019212879.1 similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm; glucose-induced degradation complex subunit VID28 1412995 34684009 LALA0_S01e14862g Lachancea lanzarotensis glucose-induced degradation complex subunit VID28 XP_022626850.1 1410056 D 1245769 CDS LALA0_S01e14884g 34684010 1413347..1416457 Unknown 1 NW_019212879.1 similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide; sulfite reductase subunit alpha 1416457 34684010 LALA0_S01e14884g Lachancea lanzarotensis sulfite reductase subunit alpha XP_022626851.1 1413347 D 1245769 CDS LALA0_S01e14906g 34684011 complement(1416573..1420085) Unknown 1 NW_019212879.1 similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus; condensin subunit SMC2 1420085 34684011 LALA0_S01e14906g Lachancea lanzarotensis condensin subunit SMC2 XP_022626852.1 1416573 R 1245769 CDS LALA0_S01e14928g 34684012 complement(join(1420765..1421525,1421839..1421842)) Unknown 1 NW_019212879.1 highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W (ohnolog of YFR031C-A) RPL2B Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures; 60S ribosomal protein uL2 1421842 34684012 LALA0_S01e14928g Lachancea lanzarotensis 60S ribosomal protein uL2 XP_022626853.1 1420765 R 1245769 CDS LALA0_S01e14950g 34684013 complement(1422787..1423686) Unknown 1 NW_019212879.1 weakly similar to uniprot|P43607 Saccharomyces cerevisiae YFR032C RRT5 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation; uncharacterized protein 1423686 34684013 LALA0_S01e14950g Lachancea lanzarotensis uncharacterized protein XP_022626854.1 1422787 R 1245769 CDS LALA0_S01e14972g 34684014 complement(1424132..1424323) Unknown 1 NW_019212879.1 highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate; 60S ribosomal protein eL29 1424323 34684014 LALA0_S01e14972g Lachancea lanzarotensis 60S ribosomal protein eL29 XP_022626855.1 1424132 R 1245769 CDS LALA0_S01e14994g 34684015 complement(1426057..1426545) Unknown 1 NW_019212879.1 similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; ubiquinol--cytochrome-c reductase subunit 6 1426545 34684015 LALA0_S01e14994g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit 6 XP_022626856.1 1426057 R 1245769 CDS LALA0_S01e15016g 34684016 complement(1427628..1429271) Unknown 1 NW_019212879.1 some similarities with uniprot|P07270 Saccharomyces cerevisiae YFR034C PHO4 Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability; phosphate-sensing transcription factor PHO4 1429271 34684016 LALA0_S01e15016g Lachancea lanzarotensis phosphate-sensing transcription factor PHO4 XP_022626857.1 1427628 R 1245769 CDS LALA0_S01e15038g 34684017 complement(1431547..1432554) Unknown 1 NW_019212879.1 similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly; uncharacterized protein 1432554 34684017 LALA0_S01e15038g Lachancea lanzarotensis uncharacterized protein XP_022626858.1 1431547 R 1245769 CDS LALA0_S01e15060g 34684018 1432817..1433611 Unknown 1 NW_019212879.1 highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase HIS6 1433611 34684018 LALA0_S01e15060g Lachancea lanzarotensis 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase HIS6 XP_022626859.1 1432817 D 1245769 CDS LALA0_S01e15082g 34684019 complement(1433756..1434706) Unknown 1 NW_019212879.1 highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W RPB3 RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit; DNA-directed RNA polymerase II core subunit RPB3 1434706 34684019 LALA0_S01e15082g Lachancea lanzarotensis DNA-directed RNA polymerase II core subunit RPB3 XP_022626860.1 1433756 R 1245769 CDS LALA0_S01e15104g 34684020 1435503..1435838 Unknown 1 NW_019212879.1 similar to uniprot|B5RSJ3 Kluyveromyces lactis KLLA0B13123g hypothetical protein; uncharacterized protein 1435838 34684020 LALA0_S01e15104g Lachancea lanzarotensis uncharacterized protein XP_022626861.1 1435503 D 1245769 CDS LALA0_S01e15126g 34684021 complement(1435956..1437194) Unknown 1 NW_019212879.1 highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); protein translocase subunit TIM44 1437194 34684021 LALA0_S01e15126g Lachancea lanzarotensis protein translocase subunit TIM44 XP_022626862.1 1435956 R 1245769 CDS LALA0_S01e15148g 34684022 1437964..1440954 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; SUMO protease ULP2 1440954 34684022 LALA0_S01e15148g Lachancea lanzarotensis SUMO protease ULP2 XP_022626863.1 1437964 D 1245769 CDS LALA0_S01e15170g 34684023 complement(1441314..1445129) Unknown 1 NW_019212879.1 similar to uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; E3 ubiquitin-protein ligase SSM4 1445129 34684023 LALA0_S01e15170g Lachancea lanzarotensis E3 ubiquitin-protein ligase SSM4 XP_022626864.1 1441314 R 1245769 CDS LALA0_S01e15214g 34684025 1445870..1446205 Unknown 1 NW_019212879.1 weakly similar to uniprot|P14724 Saccharomyces cerevisiae YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; uncharacterized protein 1446205 34684025 LALA0_S01e15214g Lachancea lanzarotensis uncharacterized protein XP_022626865.1 1445870 D 1245769 CDS LALA0_S01e15236g 34684026 complement(1446325..1446750) Unknown 1 NW_019212879.1 similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; uncharacterized protein 1446750 34684026 LALA0_S01e15236g Lachancea lanzarotensis uncharacterized protein XP_022626866.1 1446325 R 1245769 CDS LALA0_S01e15258g 34684027 complement(1446957..1450187) Unknown 1 NW_019212879.1 similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability; uncharacterized protein 1450187 34684027 LALA0_S01e15258g Lachancea lanzarotensis uncharacterized protein XP_022626867.1 1446957 R 1245769 CDS LALA0_S01e15280g 34684028 complement(join(1450737..1451198,1451428..1451613)) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; uncharacterized protein 1451613 34684028 LALA0_S01e15280g Lachancea lanzarotensis uncharacterized protein XP_022626868.1 1450737 R 1245769 CDS LALA0_S01e15302g 34684029 complement(1452117..1453454) Unknown 1 NW_019212879.1 weakly similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C YKE4 Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; Zn(2+) transporter YKE4 1453454 34684029 LALA0_S01e15302g Lachancea lanzarotensis Zn(2+) transporter YKE4 XP_022626869.1 1452117 R 1245769 CDS LALA0_S01e15324g 34684030 join(1454408..1454422,1454491..1455693) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; uncharacterized protein 1455693 34684030 LALA0_S01e15324g Lachancea lanzarotensis uncharacterized protein XP_022626870.1 1454408 D 1245769 CDS LALA0_S01e15346g 34684031 complement(1455656..1457410) Unknown 1 NW_019212879.1 similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; phosphoprotein phosphatase 1457410 34684031 LALA0_S01e15346g Lachancea lanzarotensis phosphoprotein phosphatase XP_022626871.1 1455656 R 1245769 CDS LALA0_S01e15368g 34684032 complement(1457554..1457850) Unknown 1 NW_019212879.1 weakly similar to uniprot|C5DJF4 Lachancea thermotolerans KLTH0F15972g hypothetical protein; uncharacterized protein 1457850 34684032 LALA0_S01e15368g Lachancea lanzarotensis uncharacterized protein XP_022626872.1 1457554 R 1245769 CDS LALA0_S01e15390g 34684033 1458727..1460976 Unknown 1 NW_019212879.1 similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; mitogen-activated protein kinase kinase kinase STE11 1460976 34684033 LALA0_S01e15390g Lachancea lanzarotensis mitogen-activated protein kinase kinase kinase STE11 XP_022626873.1 1458727 D 1245769 CDS LALA0_S01e15412g 34684034 1461263..1464340 Unknown 1 NW_019212879.1 similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; tethering complex subunit PEP5 1464340 34684034 LALA0_S01e15412g Lachancea lanzarotensis tethering complex subunit PEP5 XP_022626874.1 1461263 D 1245769 CDS LALA0_S01e15434g 34684035 1464504..1466483 Unknown 1 NW_019212879.1 similar to uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating; uncharacterized protein 1466483 34684035 LALA0_S01e15434g Lachancea lanzarotensis uncharacterized protein XP_022626875.1 1464504 D 1245769 CDS LALA0_S01e15456g 34684036 1466664..1467281 Unknown 1 NW_019212879.1 highly similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice; uncharacterized protein 1467281 34684036 LALA0_S01e15456g Lachancea lanzarotensis uncharacterized protein XP_022626876.1 1466664 D 1245769 CDS LALA0_S01e15478g 34684037 join(1467526..1467561,1467635..1468243) Unknown 1 NW_019212879.1 similar to uniprot|Q08747 Saccharomyces cerevisiae YOR295W (ohnolog of YMR233W) UAF30 Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; uncharacterized protein 1468243 34684037 LALA0_S01e15478g Lachancea lanzarotensis uncharacterized protein XP_022626877.1 1467526 D 1245769 CDS LALA0_S01e15500g 34684038 1468769..1472746 Unknown 1 NW_019212879.1 similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene; uncharacterized protein 1472746 34684038 LALA0_S01e15500g Lachancea lanzarotensis uncharacterized protein XP_022626878.1 1468769 D 1245769 CDS LALA0_S01e15522g 34684039 1474676..1475824 Unknown 1 NW_019212879.1 similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201); RNA-DNA hybrid ribonuclease 1475824 34684039 LALA0_S01e15522g Lachancea lanzarotensis RNA-DNA hybrid ribonuclease XP_022626879.1 1474676 D 1245769 CDS LALA0_S01e15544g 34684040 complement(1476020..1476580) Unknown 1 NW_019212879.1 similar to uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex; uncharacterized protein 1476580 34684040 LALA0_S01e15544g Lachancea lanzarotensis uncharacterized protein XP_022626880.1 1476020 R 1245769 CDS LALA0_S01e15566g 34684041 1477052..1478452 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases; uncharacterized protein 1478452 34684041 LALA0_S01e15566g Lachancea lanzarotensis uncharacterized protein XP_022626881.1 1477052 D 1245769 CDS LALA0_S01e15588g 34684042 complement(1478504..1479727) Unknown 1 NW_019212879.1 similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport; GTPase-activating protein RNA1 1479727 34684042 LALA0_S01e15588g Lachancea lanzarotensis GTPase-activating protein RNA1 XP_022626882.1 1478504 R 1245769 CDS LALA0_S01e15610g 34684043 complement(1480199..1480654) Unknown 1 NW_019212879.1 highly similar to uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; multiprotein-bridging factor 1 1480654 34684043 LALA0_S01e15610g Lachancea lanzarotensis multiprotein-bridging factor 1 XP_022626883.1 1480199 R 1245769 CDS LALA0_S01e15632g 34684044 1481764..1482987 Unknown 1 NW_019212879.1 similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases; 3'-5'-exodeoxyribonuclease 1482987 34684044 LALA0_S01e15632g Lachancea lanzarotensis 3'-5'-exodeoxyribonuclease XP_022626884.1 1481764 D 1245769 CDS LALA0_S01e15654g 34684045 complement(1483546..1484874) Unknown 1 NW_019212879.1 similar to uniprot|P39966 Saccharomyces cerevisiae YER089C (ohnolog of YBL056W) PTC2 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; type 2C protein phosphatase PTC3 1484874 34684045 LALA0_S01e15654g Lachancea lanzarotensis type 2C protein phosphatase PTC3 XP_022626885.1 1483546 R 1245769 CDS LALA0_S01e15676g 34684046 complement(1486576..1488069) Unknown 1 NW_019212879.1 similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; NADPH-adrenodoxin reductase 1488069 34684046 LALA0_S01e15676g Lachancea lanzarotensis NADPH-adrenodoxin reductase XP_022626886.1 1486576 R 1245769 CDS LALA0_S01e15698g 34684047 1488499..1489851 Unknown 1 NW_019212879.1 highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases; bifunctional AAA family ATPase chaperone/translocase BCS1 1489851 34684047 LALA0_S01e15698g Lachancea lanzarotensis bifunctional AAA family ATPase chaperone/translocase BCS1 XP_022626887.1 1488499 D 1245769 CDS LALA0_S01e15720g 34684048 1490270..1491088 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06390 Saccharomyces cerevisiae YDR374C Putative protein of unknown function; mRNA-binding phosphate metabolism regulator 1491088 34684048 LALA0_S01e15720g Lachancea lanzarotensis mRNA-binding phosphate metabolism regulator XP_022626888.1 1490270 D 1245769 CDS LALA0_S01e15742g 34684049 1491202..1491900 Unknown 1 NW_019212879.1 similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; uncharacterized protein 1491900 34684049 LALA0_S01e15742g Lachancea lanzarotensis uncharacterized protein XP_022626889.1 1491202 D 1245769 CDS LALA0_S01e15764g 34684050 complement(1492087..1492659) Unknown 1 NW_019212879.1 highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; frequenin 1492659 34684050 LALA0_S01e15764g Lachancea lanzarotensis frequenin XP_022626890.1 1492087 R 1245769 CDS LALA0_S01e15786g 34684051 1493677..1497390 Unknown 1 NW_019212879.1 similar to uniprot|Q01476 Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity; ubiquitin-specific protease UBP2 1497390 34684051 LALA0_S01e15786g Lachancea lanzarotensis ubiquitin-specific protease UBP2 XP_022626891.1 1493677 D 1245769 CDS LALA0_S01e15808g 34684052 1497747..1498766 Unknown 1 NW_019212879.1 highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74 Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function; uncharacterized protein 1498766 34684052 LALA0_S01e15808g Lachancea lanzarotensis uncharacterized protein XP_022626892.1 1497747 D 1245769 CDS LALA0_S01e15830g 34684053 complement(1498865..1500451) Unknown 1 NW_019212879.1 similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect; uncharacterized protein 1500451 34684053 LALA0_S01e15830g Lachancea lanzarotensis uncharacterized protein XP_022626893.1 1498865 R 1245769 CDS LALA0_S01e15852g 34684054 1500756..1502039 Unknown 1 NW_019212879.1 similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 1502039 34684054 LALA0_S01e15852g Lachancea lanzarotensis uncharacterized protein XP_022626894.1 1500756 D 1245769 CDS LALA0_S01e15874g 34684055 join(1502242..1502254,1502354..1502721) Unknown 1 NW_019212879.1 highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; profilin 1502721 34684055 LALA0_S01e15874g Lachancea lanzarotensis profilin XP_022626895.1 1502242 D 1245769 CDS LALA0_S01e15896g 34684056 complement(1502906..1503217) Unknown 1 NW_019212879.1 similar to uniprot|G8JU42 Eremothecium cymbalariae Ecym_4508 hypothetical protein; uncharacterized protein 1503217 34684056 LALA0_S01e15896g Lachancea lanzarotensis uncharacterized protein XP_022626896.1 1502906 R 1245769 CDS LALA0_S01e15918g 34684057 complement(1504954..1505196) Unknown 1 NW_019212879.1 weakly similar to uniprot|C5DJJ8 Lachancea thermotolerans KLTH0F17006g hypothetical protein; uncharacterized protein 1505196 34684057 LALA0_S01e15918g Lachancea lanzarotensis uncharacterized protein XP_022626897.1 1504954 R 1245769 CDS LALA0_S01e15940g 34684058 1505953..1507101 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Putative protein of unknown function; uncharacterized protein 1507101 34684058 LALA0_S01e15940g Lachancea lanzarotensis uncharacterized protein XP_022626898.1 1505953 D 1245769 CDS LALA0_S01e15962g 34684059 1507501..1508928 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85; uncharacterized protein 1508928 34684059 LALA0_S01e15962g Lachancea lanzarotensis uncharacterized protein XP_022626899.1 1507501 D 1245769 CDS LALA0_S01e15984g 34684060 1509211..1511595 Unknown 1 NW_019212879.1 weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling; uncharacterized protein 1511595 34684060 LALA0_S01e15984g Lachancea lanzarotensis uncharacterized protein XP_022626900.1 1509211 D 1245769 CDS LALA0_S01e16006g 34684061 complement(1511685..1512611) Unknown 1 NW_019212879.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; uncharacterized protein 1512611 34684061 LALA0_S01e16006g Lachancea lanzarotensis uncharacterized protein XP_022626901.1 1511685 R 1245769 CDS LALA0_S01e16028g 34684062 complement(join(1512773..1513414,1513566..1513583)) Unknown 1 NW_019212879.1 similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W KEI1 Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene; uncharacterized protein 1513583 34684062 LALA0_S01e16028g Lachancea lanzarotensis uncharacterized protein XP_022626902.1 1512773 R 1245769 CDS LALA0_S01e16050g 34684063 1513841..1515286 Unknown 1 NW_019212879.1 highly similar to uniprot|Q12196 Saccharomyces cerevisiae YOR119C RIO1 Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; protein kinase RIO1 1515286 34684063 LALA0_S01e16050g Lachancea lanzarotensis protein kinase RIO1 XP_022626903.1 1513841 D 1245769 CDS LALA0_S01e16072g 34684064 complement(1515359..1517020) Unknown 1 NW_019212879.1 similar to uniprot|Q12108 Saccharomyces cerevisiae YOR118W RTC5 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; uncharacterized protein 1517020 34684064 LALA0_S01e16072g Lachancea lanzarotensis uncharacterized protein XP_022626904.1 1515359 R 1245769 CDS LALA0_S01e16094g 34684065 1517769..1519712 Unknown 1 NW_019212879.1 similar to uniprot|Q06344 Saccharomyces cerevisiae YDR365C ESF1 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels; pre-rRNA-processing protein ESF1 1519712 34684065 LALA0_S01e16094g Lachancea lanzarotensis pre-rRNA-processing protein ESF1 XP_022626905.1 1517769 D 1245769 CDS LALA0_S01e16138g 34684067 1520081..1521472 Unknown 1 NW_019212879.1 similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; uncharacterized protein 1521472 34684067 LALA0_S01e16138g Lachancea lanzarotensis uncharacterized protein XP_022626906.1 1520081 D 1245769 CDS LALA0_S01e16160g 34684068 complement(1521516..1522820) Unknown 1 NW_019212879.1 highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1; proteasome regulatory particle base subunit RPT5 1522820 34684068 LALA0_S01e16160g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT5 XP_022626907.1 1521516 R 1245769 CDS LALA0_S01e16182g 34684069 complement(1523369..1523575) Unknown 1 NW_019212879.1 similar to uniprot|O94742 Saccharomyces cerevisiae YDR363W-A SEM1 Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; proteasome regulatory particle lid subunit SEM1 1523575 34684069 LALA0_S01e16182g Lachancea lanzarotensis proteasome regulatory particle lid subunit SEM1 XP_022626908.1 1523369 R 1245769 CDS LALA0_S01e16204g 34684070 1524756..1529138 Unknown 1 NW_019212879.1 highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C RPO31 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; DNA-directed RNA polymerase III core subunit RPO31 1529138 34684070 LALA0_S01e16204g Lachancea lanzarotensis DNA-directed RNA polymerase III core subunit RPO31 XP_022626909.1 1524756 D 1245769 CDS LALA0_S01e16248g 34684072 complement(1529473..1531083) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q06340 Saccharomyces cerevisiae YDR363W ESC2 Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member; uncharacterized protein 1531083 34684072 LALA0_S01e16248g Lachancea lanzarotensis uncharacterized protein XP_022626910.1 1529473 R 1245769 CDS LALA0_S01e16270g 34684073 complement(1531313..1532830) Unknown 1 NW_019212879.1 similar to uniprot|P38821 Saccharomyces cerevisiae YHR113W APE4 Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family; aspartyl aminopeptidase 1532830 34684073 LALA0_S01e16270g Lachancea lanzarotensis aspartyl aminopeptidase XP_022626911.1 1531313 R 1245769 CDS LALA0_S01e16292g 34684074 1533930..1535975 Unknown 1 NW_019212879.1 similar to uniprot|Q06339 Saccharomyces cerevisiae YDR362C TFC6 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110; transcription factor TFIIIC subunit TFC6 1535975 34684074 LALA0_S01e16292g Lachancea lanzarotensis transcription factor TFIIIC subunit TFC6 XP_022626912.1 1533930 D 1245769 CDS LALA0_S01e16314g 34684075 complement(1535985..1537268) Unknown 1 NW_019212879.1 highly similar to uniprot|P38820 Saccharomyces cerevisiae YHR111W UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p; uncharacterized protein 1537268 34684075 LALA0_S01e16314g Lachancea lanzarotensis uncharacterized protein XP_022626913.1 1535985 R 1245769 CDS LALA0_S01e16336g 34684076 complement(1537866..1538489) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W ERP5 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; uncharacterized protein 1538489 34684076 LALA0_S01e16336g Lachancea lanzarotensis uncharacterized protein XP_022626914.1 1537866 R 1245769 CDS LALA0_S01e16358g 34684077 complement(1538520..1540265) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38818 Saccharomyces cerevisiae YHR109W CTM1 Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth; cytochrome c lysine N-methyltransferase 1540265 34684077 LALA0_S01e16358g Lachancea lanzarotensis cytochrome c lysine N-methyltransferase XP_022626915.1 1538520 R 1245769 CDS LALA0_S01e16380g 34684078 1540681..1541490 Unknown 1 NW_019212879.1 similar to uniprot|Q06338 Saccharomyces cerevisiae YDR361C BCP1 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport; protein-transporting protein BCP1 1541490 34684078 LALA0_S01e16380g Lachancea lanzarotensis protein-transporting protein BCP1 XP_022626916.1 1540681 D 1245769 CDS LALA0_S01e16402g 34684079 1541842..1544508 Unknown 1 NW_019212879.1 similar to uniprot|Q06337 Saccharomyces cerevisiae YDR359C EAF1 Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; uncharacterized protein 1544508 34684079 LALA0_S01e16402g Lachancea lanzarotensis uncharacterized protein XP_022626917.1 1541842 D 1245769 CDS LALA0_S01e16424g 34684080 complement(1544616..1546343) Unknown 1 NW_019212879.1 similar to uniprot|P38817 Saccharomyces cerevisiae YHR108W (ohnolog of YDR358W) GGA2 Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; ubiquitin-binding protein 1546343 34684080 LALA0_S01e16424g Lachancea lanzarotensis ubiquitin-binding protein XP_022626918.1 1544616 R 1245769 CDS LALA0_S01e16446g 34684081 1547099..1547443 Unknown 1 NW_019212879.1 similar to uniprot|Q06333 Saccharomyces cerevisiae YDR357C CNL1 Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 1547443 34684081 LALA0_S01e16446g Lachancea lanzarotensis uncharacterized protein XP_022626919.1 1547099 D 1245769 CDS LALA0_S01e16468g 34684082 complement(1547462..1549960) Unknown 1 NW_019212879.1 weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; uncharacterized protein 1549960 34684082 LALA0_S01e16468g Lachancea lanzarotensis uncharacterized protein XP_022626920.1 1547462 R 1245769 CDS LALA0_S01e16490g 34684083 complement(1550316..1551419) Unknown 1 NW_019212879.1 similar to uniprot|P07285 Saccharomyces cerevisiae YDR354W TRP4 Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis; anthranilate phosphoribosyltransferase 1551419 34684083 LALA0_S01e16490g Lachancea lanzarotensis anthranilate phosphoribosyltransferase XP_022626921.1 1550316 R 1245769 CDS LALA0_S01e16512g 34684084 1552853..1554010 Unknown 1 NW_019212879.1 highly similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; septin CDC12 1554010 34684084 LALA0_S01e16512g Lachancea lanzarotensis septin CDC12 XP_022626922.1 1552853 D 1245769 CDS LALA0_S01e16534g 34684085 complement(1554227..1555255) Unknown 1 NW_019212879.1 highly similar to uniprot|P38816 Saccharomyces cerevisiae YHR106W (ohnolog of YDR353W) TRR2 Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; uncharacterized protein 1555255 34684085 LALA0_S01e16534g Lachancea lanzarotensis uncharacterized protein XP_022626923.1 1554227 R 1245769 CDS LALA0_S01e16556g 34684086 complement(1556711..1557190) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38815 Saccharomyces cerevisiae YHR105W YPT35 Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport; uncharacterized protein 1557190 34684086 LALA0_S01e16556g Lachancea lanzarotensis uncharacterized protein XP_022626924.1 1556711 R 1245769 CDS LALA0_S01e16578g 34684087 complement(1557516..1558505) Unknown 1 NW_019212879.1 highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) 1558505 34684087 LALA0_S01e16578g Lachancea lanzarotensis trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) XP_022626925.1 1557516 R 1245769 CDS LALA0_S01e16600g 34684088 complement(1559725..1560582) Unknown 1 NW_019212879.1 similar to uniprot|Q06328 Saccharomyces cerevisiae YDR352W Putative protein of unknown function; uncharacterized protein 1560582 34684088 LALA0_S01e16600g Lachancea lanzarotensis uncharacterized protein XP_022626926.1 1559725 R 1245769 CDS LALA0_S01e16622g 34684089 complement(1560898..1563396) Unknown 1 NW_019212879.1 similar to uniprot|P38814 Saccharomyces cerevisiae YHR103W (ohnolog of YDR351W) SBE22 Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth; uncharacterized protein 1563396 34684089 LALA0_S01e16622g Lachancea lanzarotensis uncharacterized protein XP_022626927.1 1560898 R 1245769 CDS LALA0_S01e16644g 34684090 complement(1563900..1566533) Unknown 1 NW_019212879.1 similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis; uncharacterized protein 1566533 34684090 LALA0_S01e16644g Lachancea lanzarotensis uncharacterized protein XP_022626928.1 1563900 R 1245769 CDS LALA0_S01e16666g 34684091 1567139..1569166 Unknown 1 NW_019212879.1 weakly similar to uniprot|P50273 Saccharomyces cerevisiae YDR350C ATP22 Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane; uncharacterized protein 1569166 34684091 LALA0_S01e16666g Lachancea lanzarotensis uncharacterized protein XP_022626929.1 1567139 D 1245769 CDS LALA0_S01e16688g 34684092 join(1569851..1569948,1570012..1570840) Unknown 1 NW_019212879.1 weakly similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan; uncharacterized protein 1570840 34684092 LALA0_S01e16688g Lachancea lanzarotensis uncharacterized protein XP_022626930.1 1569851 D 1245769 CDS LALA0_S01e16710g 34684093 1571340..1572200 Unknown 1 NW_019212879.1 similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin; SNAP receptor PEP12 1572200 34684093 LALA0_S01e16710g Lachancea lanzarotensis SNAP receptor PEP12 XP_022626931.1 1571340 D 1245769 CDS LALA0_S01e16732g 34684094 complement(1572274..1573266) Unknown 1 NW_019212879.1 similar to uniprot|Q05583 Saccharomyces cerevisiae YDR267C CIA1 WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene; iron-sulfur cluster assembly protein CIA1 1573266 34684094 LALA0_S01e16732g Lachancea lanzarotensis iron-sulfur cluster assembly protein CIA1 XP_022626932.1 1572274 R 1245769 CDS LALA0_S01e16754g 34684095 1573421..1574443 Unknown 1 NW_019212879.1 similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p); oxidoreductase 1574443 34684095 LALA0_S01e16754g Lachancea lanzarotensis oxidoreductase XP_022626933.1 1573421 D 1245769 CDS LALA0_S01e16776g 34684096 1574748..1575866 Unknown 1 NW_019212879.1 similar to uniprot|P04803 Saccharomyces cerevisiae YDR268W MSW1 Mitochondrial tryptophanyl-tRNA synthetase; tryptophan--tRNA ligase MSW1 1575866 34684096 LALA0_S01e16776g Lachancea lanzarotensis tryptophan--tRNA ligase MSW1 XP_022626934.1 1574748 D 1245769 CDS LALA0_S01e16798g 34684097 complement(1575907..1578465) Unknown 1 NW_019212879.1 similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; uncharacterized protein 1578465 34684097 LALA0_S01e16798g Lachancea lanzarotensis uncharacterized protein XP_022626935.1 1575907 R 1245769 CDS LALA0_S01e16820g 34684098 1578653..1579378 Unknown 1 NW_019212879.1 similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase; casein kinase 2 regulatory subunit CKB2 1579378 34684098 LALA0_S01e16820g Lachancea lanzarotensis casein kinase 2 regulatory subunit CKB2 XP_022626936.1 1578653 D 1245769 CDS LALA0_S01e16842g 34684099 1579851..1582811 Unknown 1 NW_019212879.1 similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; Cu(2+)-transporting P-type ATPase CCC2 1582811 34684099 LALA0_S01e16842g Lachancea lanzarotensis Cu(2+)-transporting P-type ATPase CCC2 XP_022626937.1 1579851 D 1245769 CDS LALA0_S01e16864g 34684100 1583111..1584013 Unknown 1 NW_019212879.1 similar to uniprot|Q05584 Saccharomyces cerevisiae YDR272W (ohnolog of YOR040W) GLO2 Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; uncharacterized protein 1584013 34684100 LALA0_S01e16864g Lachancea lanzarotensis uncharacterized protein XP_022626938.1 1583111 D 1245769 CDS LALA0_S01e16886g 34684101 1584397..1585860 Unknown 1 NW_019212879.1 similar to uniprot|Q05610 Saccharomyces cerevisiae YDR273W (ohnolog of YOR042W) DON1 Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; uncharacterized protein 1585860 34684101 LALA0_S01e16886g Lachancea lanzarotensis uncharacterized protein XP_022626939.1 1584397 D 1245769 CDS LALA0_S01e16908g 34684102 1587053..1588375 Unknown 1 NW_019212879.1 similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; uncharacterized protein 1588375 34684102 LALA0_S01e16908g Lachancea lanzarotensis uncharacterized protein XP_022626940.1 1587053 D 1245769 CDS LALA0_S01e16930g 34684103 1592325..1592933 Unknown 1 NW_019212879.1 weakly similar to uniprot|C5DJJ8 Lachancea thermotolerans KLTH0F17006g hypothetical protein; uncharacterized protein 1592933 34684103 LALA0_S01e16930g Lachancea lanzarotensis uncharacterized protein XP_022626941.1 1592325 D 1245769 CDS LALA0_S01e16952g 34684104 1593502..1593675 Unknown 1 NW_019212879.1 similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex; uncharacterized protein 1593675 34684104 LALA0_S01e16952g Lachancea lanzarotensis uncharacterized protein XP_022626942.1 1593502 D 1245769 CDS LALA0_S01e16974g 34684105 complement(join(1594067..1594200,1594329..1594362)) Unknown 1 NW_019212879.1 highly similar to uniprot|P87284 Saccharomyces cerevisiae YDR276C PMP3 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential; uncharacterized protein 1594362 34684105 LALA0_S01e16974g Lachancea lanzarotensis uncharacterized protein XP_022626943.1 1594067 R 1245769 CDS LALA0_S01e16996g 34684106 complement(join(1594715..1596168,1596271..1596277)) Unknown 1 NW_019212879.1 highly similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p; ATP-dependent RNA helicase DBP5 1596277 34684106 LALA0_S01e16996g Lachancea lanzarotensis ATP-dependent RNA helicase DBP5 XP_022626944.1 1594715 R 1245769 CDS LALA0_S01e17018g 34684107 complement(1596607..1597854) Unknown 1 NW_019212879.1 similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C (ohnolog of YOR047C) MTH1 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; uncharacterized protein 1597854 34684107 LALA0_S01e17018g Lachancea lanzarotensis uncharacterized protein XP_022626945.1 1596607 R 1245769 CDS LALA0_S01e17040g 34684108 1598277..1598759 Unknown 1 NW_019212879.1 hypothetical protein; uncharacterized protein 1598759 34684108 LALA0_S01e17040g Lachancea lanzarotensis uncharacterized protein XP_022626946.1 1598277 D 1245769 CDS LALA0_S01e17084g 34684110 join(1599439..1601850,1601850..1602812,1602814..1602984,1602984..1603661,1603661..1604617) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q7LHG5 Saccharomyces cerevisiae YIL082W-A TY3B-I Transposon Ty3-I Gag-Pol polyprotein; 1604617 34684110 LALA0_S01e17084g Lachancea lanzarotensis 1599439 D 1245769 CDS LALA0_S01e17106g 34684111 complement(1604814..1607786) Unknown 1 NW_019212879.1 similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination; ssRNA exonuclease RAT1 1607786 34684111 LALA0_S01e17106g Lachancea lanzarotensis ssRNA exonuclease RAT1 XP_022626947.1 1604814 R 1245769 CDS LALA0_S01e17128g 34684112 1608655..1609800 Unknown 1 NW_019212879.1 similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; type II protein arginine methyltransferase 1609800 34684112 LALA0_S01e17128g Lachancea lanzarotensis type II protein arginine methyltransferase XP_022626948.1 1608655 D 1245769 CDS LALA0_S01e17150g 34684113 complement(1610250..1611401) Unknown 1 NW_019212879.1 similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; phospholipid-translocating ATPase RSB1 1611401 34684113 LALA0_S01e17150g Lachancea lanzarotensis phospholipid-translocating ATPase RSB1 XP_022626949.1 1610250 R 1245769 CDS LALA0_S01e17172g 34684114 1613544..1615661 Unknown 1 NW_019212879.1 similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 1615661 34684114 LALA0_S01e17172g Lachancea lanzarotensis bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 XP_022626950.1 1613544 D 1245769 CDS LALA0_S01e17194g 34684115 complement(1615758..1616366) Unknown 1 NW_019212879.1 highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex; TRAPP complex core subunit BET3 1616366 34684115 LALA0_S01e17194g Lachancea lanzarotensis TRAPP complex core subunit BET3 XP_022626951.1 1615758 R 1245769 CDS LALA0_S01e17216g 34684116 complement(1616557..1617858) Unknown 1 NW_019212879.1 similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C ETT1 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough; uncharacterized protein 1617858 34684116 LALA0_S01e17216g Lachancea lanzarotensis uncharacterized protein XP_022626952.1 1616557 R 1245769 CDS LALA0_S01e17238g 34684117 1618925..1620703 Unknown 1 NW_019212879.1 similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; uroporphyrinogen-III C-methyltransferase 1620703 34684117 LALA0_S01e17238g Lachancea lanzarotensis uroporphyrinogen-III C-methyltransferase XP_022626953.1 1618925 D 1245769 CDS LALA0_S01e17260g 34684118 1621004..1622098 Unknown 1 NW_019212879.1 similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 1622098 34684118 LALA0_S01e17260g Lachancea lanzarotensis uncharacterized protein XP_022626954.1 1621004 D 1245769 CDS LALA0_S01e17282g 34684119 complement(1622268..1622630) Unknown 1 NW_019212879.1 similar to uniprot|O00017 Saccharomyces cerevisiae YOR052C Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; uncharacterized protein 1622630 34684119 LALA0_S01e17282g Lachancea lanzarotensis uncharacterized protein XP_022626955.1 1622268 R 1245769 CDS LALA0_S01e17304g 34684120 complement(1624457..1625488) Unknown 1 NW_019212879.1 similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2 Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1; electron carrier DRE2 1625488 34684120 LALA0_S01e17304g Lachancea lanzarotensis electron carrier DRE2 XP_022626956.1 1624457 R 1245769 CDS LALA0_S01e17326g 34684121 complement(1625901..1627892) Unknown 1 NW_019212879.1 similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C (ohnolog of YKR072C) VHS3 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; phosphopantothenoylcysteine decarboxylase complex subunit VHS3 1627892 34684121 LALA0_S01e17326g Lachancea lanzarotensis phosphopantothenoylcysteine decarboxylase complex subunit VHS3 XP_022626957.1 1625901 R 1245769 CDS LALA0_S01e17348g 34684122 complement(1628378..1629760) Unknown 1 NW_019212879.1 similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; rRNA-binding endoribonuclease 1629760 34684122 LALA0_S01e17348g Lachancea lanzarotensis rRNA-binding endoribonuclease XP_022626958.1 1628378 R 1245769 CDS LALA0_S01e17370g 34684123 1630202..1631332 Unknown 1 NW_019212879.1 similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; co-chaperone SGT1 1631332 34684123 LALA0_S01e17370g Lachancea lanzarotensis co-chaperone SGT1 XP_022626959.1 1630202 D 1245769 CDS LALA0_S01e17392g 34684124 complement(1631403..1634210) Unknown 1 NW_019212879.1 similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; uncharacterized protein 1634210 34684124 LALA0_S01e17392g Lachancea lanzarotensis uncharacterized protein XP_022626960.1 1631403 R 1245769 CDS LALA0_S01e17436g 34684126 join(1634835..1634892,1634969..1635348) Unknown 1 NW_019212879.1 similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W AIM29 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 1635348 34684126 LALA0_S01e17436g Lachancea lanzarotensis uncharacterized protein XP_022626961.1 1634835 D 1245769 CDS LALA0_S01e17458g 34684127 complement(1635644..1637032) Unknown 1 NW_019212879.1 similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4; uncharacterized protein 1637032 34684127 LALA0_S01e17458g Lachancea lanzarotensis uncharacterized protein XP_022626962.1 1635644 R 1245769 CDS LALA0_S01e17480g 34684128 complement(1637551..1638276) Unknown 1 NW_019212879.1 similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C SLD7 Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; uncharacterized protein 1638276 34684128 LALA0_S01e17480g Lachancea lanzarotensis uncharacterized protein XP_022626963.1 1637551 R 1245769 CDS LALA0_S01e17502g 34684129 1639259..1640281 Unknown 1 NW_019212879.1 highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase; casein kinase 2 catalytic subunit CKA2 1640281 34684129 LALA0_S01e17502g Lachancea lanzarotensis casein kinase 2 catalytic subunit CKA2 XP_022626964.1 1639259 D 1245769 CDS LALA0_S01e17524g 34684130 complement(1640615..1641436) Unknown 1 NW_019212879.1 weakly similar to uniprot|P36025 Saccharomyces cerevisiae YOR062C (ohnolog of YKR075C) Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; uncharacterized protein 1641436 34684130 LALA0_S01e17524g Lachancea lanzarotensis uncharacterized protein XP_022626965.1 1640615 R 1245769 CDS LALA0_S01e17546g 34684131 1643402..1644565 Unknown 1 NW_019212879.1 highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W RPL3 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus; 60S ribosomal protein uL3 1644565 34684131 LALA0_S01e17546g Lachancea lanzarotensis 60S ribosomal protein uL3 XP_022626966.1 1643402 D 1245769 CDS LALA0_S01e17568g 34684132 complement(1644840..1645385) Unknown 1 NW_019212879.1 weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1; uncharacterized protein 1645385 34684132 LALA0_S01e17568g Lachancea lanzarotensis uncharacterized protein XP_022626967.1 1644840 R 1245769 CDS LALA0_S01e17590g 34684133 join(1646363..1646404,1646855..1647724) Unknown 1 NW_019212879.1 highly similar to uniprot|P07143 Saccharomyces cerevisiae YOR065W CYT1 Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex; ubiquinol--cytochrome-c reductase catalytic subunit CYT1 1647724 34684133 LALA0_S01e17590g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase catalytic subunit CYT1 XP_022626968.1 1646363 D 1245769 CDS LALA0_S01e17612g 34684134 1650035..1651453 Unknown 1 NW_019212879.1 weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W (ohnolog of YKR077W) MSA1 Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; uncharacterized protein 1651453 34684134 LALA0_S01e17612g Lachancea lanzarotensis uncharacterized protein XP_022626969.1 1650035 D 1245769 CDS LALA0_S01e17634g 34684135 complement(1651626..1653296) Unknown 1 NW_019212879.1 similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase 1653296 34684135 LALA0_S01e17634g Lachancea lanzarotensis dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase XP_022626970.1 1651626 R 1245769 CDS LALA0_S01e17656g 34684136 1653441..1655387 Unknown 1 NW_019212879.1 similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W (ohnolog of YKR078W) VPS5 Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; sorting nexin 1 1655387 34684136 LALA0_S01e17656g Lachancea lanzarotensis sorting nexin 1 XP_022626971.1 1653441 D 1245769 CDS LALA0_S01e17678g 34684137 complement(1655459..1657903) Unknown 1 NW_019212879.1 similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2; tRNase Z 1657903 34684137 LALA0_S01e17678g Lachancea lanzarotensis tRNase Z XP_022626972.1 1655459 R 1245769 CDS LALA0_S01e17700g 34684138 complement(1658244..1660010) Unknown 1 NW_019212879.1 similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; GTPase-activating protein GYP1 1660010 34684138 LALA0_S01e17700g Lachancea lanzarotensis GTPase-activating protein GYP1 XP_022626973.1 1658244 R 1245769 CDS LALA0_S01e17722g 34684139 1660890..1661852 Unknown 1 NW_019212879.1 highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline; methylenetetrahydrofolate dehydrogenase (NAD(+)) 1661852 34684139 LALA0_S01e17722g Lachancea lanzarotensis methylenetetrahydrofolate dehydrogenase (NAD(+)) XP_022626974.1 1660890 D 1245769 CDS LALA0_S01e17744g 34684140 complement(join(1662010..1663018,1663130..1663143)) Unknown 1 NW_019212879.1 highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA-binding ribosome biosynthesis protein RPF2 1663143 34684140 LALA0_S01e17744g Lachancea lanzarotensis rRNA-binding ribosome biosynthesis protein RPF2 XP_022626975.1 1662010 R 1245769 CDS LALA0_S01e17766g 34684141 1663401..1666826 Unknown 1 NW_019212879.1 similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 1666826 34684141 LALA0_S01e17766g Lachancea lanzarotensis uncharacterized protein XP_022626976.1 1663401 D 1245769 CDS LALA0_S01e17788g 34684142 complement(1666873..1667241) Unknown 1 NW_019212879.1 similar to uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 1667241 34684142 LALA0_S01e17788g Lachancea lanzarotensis uncharacterized protein XP_022626977.1 1666873 R 1245769 CDS LALA0_S01e17810g 34684143 1667660..1669528 Unknown 1 NW_019212879.1 similar to uniprot|Q08490 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; uncharacterized protein 1669528 34684143 LALA0_S01e17810g Lachancea lanzarotensis uncharacterized protein XP_022626978.1 1667660 D 1245769 CDS LALA0_S01e17832g 34684144 complement(1669571..1670506) Unknown 1 NW_019212879.1 highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; thymidylate synthase 1670506 34684144 LALA0_S01e17832g Lachancea lanzarotensis thymidylate synthase XP_022626979.1 1669571 R 1245769 CDS LALA0_S01e17854g 34684145 1671393..1672376 Unknown 1 NW_019212879.1 similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER; uncharacterized protein 1672376 34684145 LALA0_S01e17854g Lachancea lanzarotensis uncharacterized protein XP_022626980.1 1671393 D 1245769 CDS LALA0_S01e17876g 34684146 complement(join(1672404..1674655,1674996..1675263)) Unknown 1 NW_019212879.1 some similarities with uniprot|Q08491 Saccharomyces cerevisiae YOR076C (ohnolog of YKR084C) SKI7 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype; ribosome dissociation factor GTPase HBS1 1675263 34684146 LALA0_S01e17876g Lachancea lanzarotensis ribosome dissociation factor GTPase HBS1 XP_022626981.1 1672404 R 1245769 CDS LALA0_S01e17898g 34684147 1676071..1676556 Unknown 1 NW_019212879.1 similar to uniprot|C5DJP5 Lachancea thermotolerans KLTH0F18084g hypothetical protein; uncharacterized protein 1676556 34684147 LALA0_S01e17898g Lachancea lanzarotensis uncharacterized protein XP_022626982.1 1676071 D 1245769 CDS LALA0_S01e17920g 34684148 complement(1676774..1677376) Unknown 1 NW_019212879.1 similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL58 1677376 34684148 LALA0_S01e17920g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL58 XP_022626983.1 1676774 R 1245769 CDS LALA0_S01e17942g 34684149 1678268..1681618 Unknown 1 NW_019212879.1 similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; DEAH-box RNA helicase PRP16 1681618 34684149 LALA0_S01e17942g Lachancea lanzarotensis DEAH-box RNA helicase PRP16 XP_022626984.1 1678268 D 1245769 CDS LALA0_S01e17964g 34684150 complement(1681623..1682672) Unknown 1 NW_019212879.1 similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; metalloendopeptidase 1682672 34684150 LALA0_S01e17964g Lachancea lanzarotensis metalloendopeptidase XP_022626985.1 1681623 R 1245769 CDS LALA0_S01e17986g 34684151 1682871..1683599 Unknown 1 NW_019212879.1 similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W RTS2 Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication; uncharacterized protein 1683599 34684151 LALA0_S01e17986g Lachancea lanzarotensis uncharacterized protein XP_022626986.1 1682871 D 1245769 CDS LALA0_S01e18008g 34684152 complement(1683682..1684608) Unknown 1 NW_019212879.1 similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1684608 34684152 LALA0_S01e18008g Lachancea lanzarotensis uncharacterized protein XP_022626987.1 1683682 R 1245769 CDS LALA0_S01e18030g 34684153 1686624..1687484 Unknown 1 NW_019212879.1 weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; uncharacterized protein 1687484 34684153 LALA0_S01e18030g Lachancea lanzarotensis uncharacterized protein XP_022626988.1 1686624 D 1245769 CDS LALA0_S01e18052g 34684154 1688263..1688889 Unknown 1 NW_019212879.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 1688889 34684154 LALA0_S01e18052g Lachancea lanzarotensis uncharacterized protein XP_022626989.1 1688263 D 1245769 CDS LALA0_S01e18074g 34684155 1689561..1690256 Unknown 1 NW_019212879.1 similar to uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern; uncharacterized protein 1690256 34684155 LALA0_S01e18074g Lachancea lanzarotensis uncharacterized protein XP_022626990.1 1689561 D 1245769 CDS LALA0_S01e18096g 34684156 complement(1690406..1691401) Unknown 1 NW_019212879.1 similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation; Mn(2+) transporter ATX2 1691401 34684156 LALA0_S01e18096g Lachancea lanzarotensis Mn(2+) transporter ATX2 XP_022626991.1 1690406 R 1245769 CDS LALA0_S01e18118g 34684157 1691631..1693700 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; DNA-binding SCF ubiquitin ligase subunit DIA2 1693700 34684157 LALA0_S01e18118g Lachancea lanzarotensis DNA-binding SCF ubiquitin ligase subunit DIA2 XP_022626992.1 1691631 D 1245769 CDS LALA0_S01e18140g 34684158 complement(1693746..1696295) Unknown 1 NW_019212879.1 similar to uniprot|Q12043 Saccharomyces cerevisiae YOR081C (ohnolog of YKR089C) TGL5 Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate; uncharacterized protein 1696295 34684158 LALA0_S01e18140g Lachancea lanzarotensis uncharacterized protein XP_022626993.1 1693746 R 1245769 CDS LALA0_S01e18162g 34684159 1697836..1699350 Unknown 1 NW_019212879.1 similar to uniprot|P40016 Saccharomyces cerevisiae YER021W RPN3 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control; proteasome regulatory particle lid subunit RPN3 1699350 34684159 LALA0_S01e18162g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN3 XP_022626994.1 1697836 D 1245769 CDS LALA0_S01e18184g 34684160 1699588..1701522 Unknown 1 NW_019212879.1 similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination; uncharacterized protein 1701522 34684160 LALA0_S01e18184g Lachancea lanzarotensis uncharacterized protein XP_022626995.1 1699588 D 1245769 CDS LALA0_S01e18206g 34684161 complement(1701626..1702174) Unknown 1 NW_019212879.1 similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth; uncharacterized protein 1702174 34684161 LALA0_S01e18206g Lachancea lanzarotensis uncharacterized protein XP_022626996.1 1701626 R 1245769 CDS LALA0_S01e18228g 34684162 complement(1702499..1703344) Unknown 1 NW_019212879.1 highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis; pyrroline-5-carboxylate reductase 1703344 34684162 LALA0_S01e18228g Lachancea lanzarotensis pyrroline-5-carboxylate reductase XP_022626997.1 1702499 R 1245769 CDS LALA0_S01e18250g 34684163 1703941..1706328 Unknown 1 NW_019212879.1 similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C JHD2 JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation; histone demethylase 1706328 34684163 LALA0_S01e18250g Lachancea lanzarotensis histone demethylase XP_022626998.1 1703941 D 1245769 CDS LALA0_S01e18272g 34684164 1707379..1708866 Unknown 1 NW_019212879.1 highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; F1F0 ATP synthase subunit beta 1708866 34684164 LALA0_S01e18272g Lachancea lanzarotensis F1F0 ATP synthase subunit beta XP_022626999.1 1707379 D 1245769 CDS LALA0_S01e18294g 34684165 1709414..1710817 Unknown 1 NW_019212879.1 similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W IBA57 Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system; uncharacterized protein 1710817 34684165 LALA0_S01e18294g Lachancea lanzarotensis uncharacterized protein XP_022627000.1 1709414 D 1245769 CDS LALA0_S01e18316g 34684166 1711600..1712286 Unknown 1 NW_019212879.1 highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W RPS5 Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins; 40S ribosomal protein uS7 1712286 34684166 LALA0_S01e18316g Lachancea lanzarotensis 40S ribosomal protein uS7 XP_022627001.1 1711600 D 1245769 CDS LALA0_S01e18338g 34684167 1713370..1715682 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40017 Saccharomyces cerevisiae YER024W YAT2 Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane; carnitine O-acetyltransferase YAT2 1715682 34684167 LALA0_S01e18338g Lachancea lanzarotensis carnitine O-acetyltransferase YAT2 XP_022627002.1 1713370 D 1245769 CDS LALA0_S01e18360g 34684168 complement(1715737..1717047) Unknown 1 NW_019212879.1 similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Putative protein of unknown function; expression induced under calcium shortage; uncharacterized protein 1717047 34684168 LALA0_S01e18360g Lachancea lanzarotensis uncharacterized protein XP_022627003.1 1715737 R 1245769 CDS LALA0_S01e18382g 34684169 1717275..1719743 Unknown 1 NW_019212879.1 similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis; leucine-responsive transcriptional regulator LEU3 1719743 34684169 LALA0_S01e18382g Lachancea lanzarotensis leucine-responsive transcriptional regulator LEU3 XP_022627004.1 1717275 D 1245769 CDS LALA0_S01e18404g 34684170 1720147..1721736 Unknown 1 NW_019212879.1 highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; translation initiation factor eIF2 subunit gamma 1721736 34684170 LALA0_S01e18404g Lachancea lanzarotensis translation initiation factor eIF2 subunit gamma XP_022627005.1 1720147 D 1245769 CDS LALA0_S01e18426g 34684171 complement(1721941..1723998) Unknown 1 NW_019212879.1 similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family; GTPase-activating protein SST2 1723998 34684171 LALA0_S01e18426g Lachancea lanzarotensis GTPase-activating protein SST2 XP_022627006.1 1721941 R 1245769 CDS LALA0_S01e18448g 34684172 complement(1724417..1726342) Unknown 1 NW_019212879.1 similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins; cyclin-dependent serine/threonine protein kinase SGV1 1726342 34684172 LALA0_S01e18448g Lachancea lanzarotensis cyclin-dependent serine/threonine protein kinase SGV1 XP_022627007.1 1724417 R 1245769 CDS LALA0_S01e18470g 34684173 complement(1726764..1728500) Unknown 1 NW_019212879.1 similar to uniprot|Q06208 Saccharomyces cerevisiae YLR453C (ohnolog of YPR162C) RIF2 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; origin recognition complex subunit 4 1728500 34684173 LALA0_S01e18470g Lachancea lanzarotensis origin recognition complex subunit 4 XP_022627008.1 1726764 R 1245769 CDS LALA0_S01e18514g 34684174 complement(1729023..1731413) Unknown 1 NW_019212879.1 putative transposase of the Rover4 hAT-like DNA transposon 1731413 34684174 LALA0_S01e18514g Lachancea lanzarotensis putative transposase of the Rover4 hAT-like DNA transposon XP_022627009.1 1729023 R 1245769 CDS LALA0_S01e18558g 34684175 1733734..1735365 Unknown 1 NW_019212879.1 highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol; phosphoenolpyruvate carboxykinase PCK1 1735365 34684175 LALA0_S01e18558g Lachancea lanzarotensis phosphoenolpyruvate carboxykinase PCK1 XP_022627010.1 1733734 D 1245769 CDS LALA0_S01e18580g 34684176 complement(1735510..1736622) Unknown 1 NW_019212879.1 similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; peptidylprolyl isomerase RRD1 1736622 34684176 LALA0_S01e18580g Lachancea lanzarotensis peptidylprolyl isomerase RRD1 XP_022627011.1 1735510 R 1245769 CDS LALA0_S01e18602g 34684177 1737406..1738404 Unknown 1 NW_019212879.1 similar to uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat; uncharacterized protein 1738404 34684177 LALA0_S01e18602g Lachancea lanzarotensis uncharacterized protein XP_022627012.1 1737406 D 1245769 CDS LALA0_S01e18624g 34684178 1740003..1741925 Unknown 1 NW_019212879.1 similar to uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner; glycerol-3-phosphate dehydrogenase 1741925 34684178 LALA0_S01e18624g Lachancea lanzarotensis glycerol-3-phosphate dehydrogenase XP_022627013.1 1740003 D 1245769 CDS LALA0_S01e18646g 34684179 complement(1742165..1745098) Unknown 1 NW_019212879.1 similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W (ohnolog of YKR098C) UBP7 Ubiquitin-specificprotease that cleaves ubiquitin-protein fusions; ubiquitin-specific protease UBP7 1745098 34684179 LALA0_S01e18646g Lachancea lanzarotensis ubiquitin-specific protease UBP7 XP_022627014.1 1742165 R 1245769 CDS LALA0_S01e18668g 34684180 1746112..1748301 Unknown 1 NW_019212879.1 weakly similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes; uncharacterized protein 1748301 34684180 LALA0_S01e18668g Lachancea lanzarotensis uncharacterized protein XP_022627015.1 1746112 D 1245769 CDS LALA0_S01e18690g 34684181 complement(join(1748504..1748716,1748826..1748834)) Unknown 1 NW_019212879.1 highly similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B Putative protein of unknown function, originally identified based on homology to Ashbya gossypii and other related yeasts; mitofissin 1748834 34684181 LALA0_S01e18690g Lachancea lanzarotensis mitofissin XP_022627016.1 1748504 R 1245769 CDS LALA0_S01e18712g 34684182 1749098..1749679 Unknown 1 NW_019212879.1 similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C COA1 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly; uncharacterized protein 1749679 34684182 LALA0_S01e18712g Lachancea lanzarotensis uncharacterized protein XP_022627017.1 1749098 D 1245769 CDS LALA0_S01e18734g 34684183 complement(1749844..1750938) Unknown 1 NW_019212879.1 similar to uniprot|P40451 Saccharomyces cerevisiae YIL158W (ohnolog of YKR100C) AIM20 Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 1750938 34684183 LALA0_S01e18734g Lachancea lanzarotensis uncharacterized protein XP_022627018.1 1749844 R 1245769 CDS LALA0_S01e18756g 34684184 complement(1751635..1755741) Unknown 1 NW_019212879.1 similar to uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1; formin BNR1 1755741 34684184 LALA0_S01e18756g Lachancea lanzarotensis formin BNR1 XP_022627019.1 1751635 R 1245769 CDS LALA0_S01e18778g 34684185 complement(1756820..1757488) Unknown 1 NW_019212879.1 similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels; dethiobiotin synthase 1757488 34684185 LALA0_S01e18778g Lachancea lanzarotensis dethiobiotin synthase XP_022627020.1 1756820 R 1245769 CDS LALA0_S01e18800g 34684186 1757873..1759354 Unknown 1 NW_019212879.1 similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; adenosylmethionine-8-amino-7-oxononanoate transaminase 1759354 34684186 LALA0_S01e18800g Lachancea lanzarotensis adenosylmethionine-8-amino-7-oxononanoate transaminase XP_022627021.1 1757873 D 1245769 CDS LALA0_S01e18822g 34684187 1760183..1762147 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; uncharacterized protein 1762147 34684187 LALA0_S01e18822g Lachancea lanzarotensis uncharacterized protein XP_022627022.1 1760183 D 1245769 CDS LALA0_S01e18844g 34684188 1762721..1763407 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene; uncharacterized protein 1763407 34684188 LALA0_S01e18844g Lachancea lanzarotensis uncharacterized protein XP_022627023.1 1762721 D 1245769 CDS LALA0_S01e18866g 34684189 complement(1763421..1764644) Unknown 1 NW_019212879.1 similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; acetyl-CoA C-acyltransferase 1764644 34684189 LALA0_S01e18866g Lachancea lanzarotensis acetyl-CoA C-acyltransferase XP_022627024.1 1763421 R 1245769 CDS LALA0_S01e18888g 34684190 1767512..1769203 Unknown 1 NW_019212879.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; uncharacterized protein 1769203 34684190 LALA0_S01e18888g Lachancea lanzarotensis uncharacterized protein XP_022627025.1 1767512 D 1245769 CDS LALA0_S01e18910g 34684191 1771036..1772799 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation; uncharacterized protein 1772799 34684191 LALA0_S01e18910g Lachancea lanzarotensis uncharacterized protein XP_022627026.1 1771036 D 1245769 CDS LALA0_S01e18932g 34684192 1773864..1775525 Unknown 1 NW_019212879.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; allantoate permease 1775525 34684192 LALA0_S01e18932g Lachancea lanzarotensis allantoate permease XP_022627027.1 1773864 D 1245769 CDS LALA0_S01e18954g 34684193 1776751..1778592 Unknown 1 NW_019212879.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; uncharacterized protein 1778592 34684193 LALA0_S01e18954g Lachancea lanzarotensis uncharacterized protein XP_022627028.1 1776751 D 1245769 CDS LALA0_S01e18976g 34684194 1780177..1781793 Unknown 1 NW_019212879.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene; uncharacterized protein 1781793 34684194 LALA0_S01e18976g Lachancea lanzarotensis uncharacterized protein XP_022627029.1 1780177 D 1245769 CDS LALA0_S01e18998g 34684195 1783228..1785231 Unknown 1 NW_019212879.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; uncharacterized protein 1785231 34684195 LALA0_S01e18998g Lachancea lanzarotensis uncharacterized protein XP_022627030.1 1783228 D 1245769 CDS LALA0_S01e19020g 34684196 complement(1785388..1786929) Unknown 1 NW_019212879.1 highly similar to uniprot|C5DC69 Lachancea thermotolerans KLTH0B00462g flavin-containing monooxygenase; uncharacterized protein 1786929 34684196 LALA0_S01e19020g Lachancea lanzarotensis uncharacterized protein XP_022627031.1 1785388 R 1245769 CDS LALA0_S01e19042g 34684197 1787412..1788614 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS; uncharacterized protein 1788614 34684197 LALA0_S01e19042g Lachancea lanzarotensis uncharacterized protein XP_022627032.1 1787412 D 1245769 CDS LALA0_S01e19064g 34684198 join(1788887..1789495,1789495..1790586) Unknown 1 NW_019212879.1 weakly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock; 1790586 34684198 LALA0_S01e19064g Lachancea lanzarotensis 1788887 D 1245769 CDS LALA0_S01e19086g 34684199 1791122..1792915 Unknown 1 NW_019212879.1 similar to uniprot|Q6CEC0 Yarrowia lipolytica YALI0B16852g hypothetical protein; uncharacterized protein 1792915 34684199 LALA0_S01e19086g Lachancea lanzarotensis uncharacterized protein XP_022627033.1 1791122 D 1245769 CDS LALA0_S01e19108g 34684200 complement(1793867..1794613) Unknown 1 NW_019212879.1 weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; uncharacterized protein 1794613 34684200 LALA0_S01e19108g Lachancea lanzarotensis uncharacterized protein XP_022627034.1 1793867 R 1245769 CDS LALA0_S01e19130g 34684201 1795829..1796716 Unknown 1 NW_019212879.1 weakly similar to Lachancea thermotolerans KLTH0E03080g hypothetical protein; uncharacterized protein 1796716 34684201 LALA0_S01e19130g Lachancea lanzarotensis uncharacterized protein XP_022627035.1 1795829 D 1245769 CDS LALA0_S01e19152g 34684202 complement(1797902..1799746) Unknown 1 NW_019212879.1 highly similar to uniprot|P0CD99 Saccharomyces cerevisiae YDL247W MPH2 Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication; uncharacterized protein 1799746 34684202 LALA0_S01e19152g Lachancea lanzarotensis uncharacterized protein XP_022627036.1 1797902 R 1245769 CDS LALA0_S01e19174g 34684203 1800657..1802411 Unknown 1 NW_019212879.1 highly similar to uniprot|P38158 Saccharomyces cerevisiae YBR299W MAL32 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; uncharacterized protein 1802411 34684203 LALA0_S01e19174g Lachancea lanzarotensis uncharacterized protein XP_022627037.1 1800657 D 1245769 CDS LALA0_S01e19196g 34684204 complement(1803223..1804575) Unknown 1 NW_019212879.1 some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C (ohnolog of YDR133C) CCW12 Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; uncharacterized protein 1804575 34684204 LALA0_S01e19196g Lachancea lanzarotensis uncharacterized protein XP_022627038.1 1803223 R 1245769 CDS LALA0_S01e19218g 34684205 1807013..1808539 Unknown 1 NW_019212879.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); uncharacterized protein 1808539 34684205 LALA0_S01e19218g Lachancea lanzarotensis uncharacterized protein XP_022627039.1 1807013 D 1245769 CDS LALA0_S01e19240g 34684206 1809409..1810299 Unknown 1 NW_019212879.1 similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis; uncharacterized protein 1810299 34684206 LALA0_S01e19240g Lachancea lanzarotensis uncharacterized protein XP_022627040.1 1809409 D 1245769 CDS LALA0_S01e19284g 34684208 complement(1813238..1814935) Unknown 1 NW_019212879.1 similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane; uncharacterized protein 1814935 34684208 LALA0_S01e19284g Lachancea lanzarotensis uncharacterized protein XP_022627041.1 1813238 R 1245769 CDS LALA0_S01e19306g 34684209 1815459..1815839 Unknown 1 NW_019212879.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes; uncharacterized protein 1815839 34684209 LALA0_S01e19306g Lachancea lanzarotensis uncharacterized protein XP_022627042.1 1815459 D 1245769 CDS LALA0_S01e19328g 34684210 complement(1816270..1817778) Unknown 1 NW_019212879.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); uncharacterized protein 1817778 34684210 LALA0_S01e19328g Lachancea lanzarotensis uncharacterized protein XP_022627043.1 1816270 R 1245769 CDS LALA0_S01e19350g 34684211 1818492..1821038 Unknown 1 NW_019212879.1 weakly similar to uniprot|Q12139 Saccharomyces cerevisiae YPR022C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; uncharacterized protein 1821038 34684211 LALA0_S01e19350g Lachancea lanzarotensis uncharacterized protein XP_022627044.1 1818492 D 1245769 CDS LALA0_S01e19372g 34684212 complement(1821080..1822327) Unknown 1 NW_019212879.1 similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W DSD1 D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate; D-serine ammonia-lyase DSD1 1822327 34684212 LALA0_S01e19372g Lachancea lanzarotensis D-serine ammonia-lyase DSD1 XP_022627045.1 1821080 R 1245769 CDS LALA0_S01e19394g 34684213 1822712..1823788 Unknown 1 NW_019212879.1 highly similar to Lachancea thermotolerans KLTH0F03982g hypothetical protein; uncharacterized protein 1823788 34684213 LALA0_S01e19394g Lachancea lanzarotensis uncharacterized protein XP_022627046.1 1822712 D 1245769 CDS LALA0_S01e19416g 34684214 1827213..1828985 Unknown 1 NW_019212879.1 some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p; 1828985 34684214 LALA0_S01e19416g Lachancea lanzarotensis 1827213 D 1245769 CDS LALA0_S02e00100g 34684215 379..591 Unknown 1 NW_019212880.1 highly similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL33m 591 34684215 LALA0_S02e00100g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL33m XP_022627047.1 379 D 1245769 CDS LALA0_S02e00122g 34684216 complement(923..4006) Unknown 1 NW_019212880.1 similar to uniprot|P27692 Saccharomyces cerevisiae YML010W SPT5 Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p; transcription elongation factor SPT5 4006 34684216 LALA0_S02e00122g Lachancea lanzarotensis transcription elongation factor SPT5 XP_022627048.1 923 R 1245769 CDS LALA0_S02e00144g 34684217 4310..4843 Unknown 1 NW_019212880.1 similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C RAD33 Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; uncharacterized protein 4843 34684217 LALA0_S02e00144g Lachancea lanzarotensis uncharacterized protein XP_022627049.1 4310 D 1245769 CDS LALA0_S02e00166g 34684218 complement(4874..5503) Unknown 1 NW_019212880.1 highly similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport; uncharacterized protein 5503 34684218 LALA0_S02e00166g Lachancea lanzarotensis uncharacterized protein XP_022627050.1 4874 R 1245769 CDS LALA0_S02e00188g 34684219 complement(5956..8916) Unknown 1 NW_019212880.1 similar to uniprot|P32898 Saccharomyces cerevisiae YDR430C CYM1 Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; pitrilysin family metalloprotease 8916 34684219 LALA0_S02e00188g Lachancea lanzarotensis pitrilysin family metalloprotease XP_022627051.1 5956 R 1245769 CDS LALA0_S02e00210g 34684220 10443..11576 Unknown 1 NW_019212880.1 similar to uniprot|Q01560 Saccharomyces cerevisiae YDR432W NPL3 RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; mRNA-binding protein NPL3 11576 34684220 LALA0_S02e00210g Lachancea lanzarotensis mRNA-binding protein NPL3 XP_022627052.1 10443 D 1245769 CDS LALA0_S02e00232g 34684221 complement(12263..14035) Unknown 1 NW_019212880.1 similar to uniprot|Q04228 Saccharomyces cerevisiae YML013W UBX2 Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; uncharacterized protein 14035 34684221 LALA0_S02e00232g Lachancea lanzarotensis uncharacterized protein XP_022627053.1 12263 R 1245769 CDS LALA0_S02e00254g 34684222 complement(14184..15023) Unknown 1 NW_019212880.1 similar to uniprot|P49957 Saccharomyces cerevisiae YML014W TRM9 tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase 15023 34684222 LALA0_S02e00254g Lachancea lanzarotensis tRNA (carboxymethyluridine(34)-5-O)-methyltransferase XP_022627054.1 14184 R 1245769 CDS LALA0_S02e00276g 34684223 15484..17085 Unknown 1 NW_019212880.1 similar to uniprot|Q04080 Saccharomyces cerevisiae YDR434W GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog; GPI-anchor transamidase GPI17 17085 34684223 LALA0_S02e00276g Lachancea lanzarotensis GPI-anchor transamidase GPI17 XP_022627055.1 15484 D 1245769 CDS LALA0_S02e00298g 34684224 17434..18456 Unknown 1 NW_019212880.1 similar to uniprot|Q04226 Saccharomyces cerevisiae YML015C TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors; TATA-binding protein-associated factor TAF11 18456 34684224 LALA0_S02e00298g Lachancea lanzarotensis TATA-binding protein-associated factor TAF11 XP_022627056.1 17434 D 1245769 CDS LALA0_S02e00320g 34684225 complement(18501..19487) Unknown 1 NW_019212880.1 similar to uniprot|Q04081 Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; leucine carboxy methyltransferase 19487 34684225 LALA0_S02e00320g Lachancea lanzarotensis leucine carboxy methyltransferase XP_022627057.1 18501 R 1245769 CDS LALA0_S02e00342g 34684226 20701..21864 Unknown 1 NW_019212880.1 similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder; ubiquitin-protein ligase peroxin 12 21864 34684226 LALA0_S02e00342g Lachancea lanzarotensis ubiquitin-protein ligase peroxin 12 XP_022627058.1 20701 D 1245769 CDS LALA0_S02e00364g 34684227 complement(21875..22624) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04368 Saccharomyces cerevisiae YMR025W CSI1 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; uncharacterized protein 22624 34684227 LALA0_S02e00364g Lachancea lanzarotensis uncharacterized protein XP_022627059.1 21875 R 1245769 CDS LALA0_S02e00386g 34684228 complement(22838..23968) Unknown 1 NW_019212880.1 similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL44 23968 34684228 LALA0_S02e00386g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL44 XP_022627060.1 22838 R 1245769 CDS LALA0_S02e00408g 34684229 complement(25603..26550) Unknown 1 NW_019212880.1 weakly similar to uniprot|C5DGR7 Lachancea thermotolerans KLTH0D07524g hypothetical protein; uncharacterized protein 26550 34684229 LALA0_S02e00408g Lachancea lanzarotensis uncharacterized protein XP_022627061.1 25603 R 1245769 CDS LALA0_S02e00430g 34684230 27011..28504 Unknown 1 NW_019212880.1 similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C MSS1 Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3; uncharacterized protein 28504 34684230 LALA0_S02e00430g Lachancea lanzarotensis uncharacterized protein XP_022627062.1 27011 D 1245769 CDS LALA0_S02e00452g 34684231 complement(28528..28866) Unknown 1 NW_019212880.1 similar to uniprot|P35727 Saccharomyces cerevisiae YKL061W BLI1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; uncharacterized protein 28866 34684231 LALA0_S02e00452g Lachancea lanzarotensis uncharacterized protein XP_022627063.1 28528 R 1245769 CDS LALA0_S02e00474g 34684232 30341..31921 Unknown 1 NW_019212880.1 similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 31921 34684232 LALA0_S02e00474g Lachancea lanzarotensis uncharacterized protein XP_022627064.1 30341 D 1245769 CDS LALA0_S02e00496g 34684233 complement(32099..33445) Unknown 1 NW_019212880.1 similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; uncharacterized protein 33445 34684233 LALA0_S02e00496g Lachancea lanzarotensis uncharacterized protein XP_022627065.1 32099 R 1245769 CDS LALA0_S02e00518g 34684234 complement(33889..34386) Unknown 1 NW_019212880.1 highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W UBC7 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; E2 ubiquitin-conjugating protein UBC7 34386 34684234 LALA0_S02e00518g Lachancea lanzarotensis E2 ubiquitin-conjugating protein UBC7 XP_022627066.1 33889 R 1245769 CDS LALA0_S02e00540g 34684235 34930..36174 Unknown 1 NW_019212880.1 similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport; uncharacterized protein 36174 34684235 LALA0_S02e00540g Lachancea lanzarotensis uncharacterized protein XP_022627067.1 34930 D 1245769 CDS LALA0_S02e00562g 34684236 complement(36261..37769) Unknown 1 NW_019212880.1 similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; polyamine oxidase 37769 34684236 LALA0_S02e00562g Lachancea lanzarotensis polyamine oxidase XP_022627068.1 36261 R 1245769 CDS LALA0_S02e00584g 34684237 38659..40176 Unknown 1 NW_019212880.1 similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair; DNA primase subunit PRI2 40176 34684237 LALA0_S02e00584g Lachancea lanzarotensis DNA primase subunit PRI2 XP_022627069.1 38659 D 1245769 CDS LALA0_S02e00606g 34684238 complement(40223..42160) Unknown 1 NW_019212880.1 some similarities with uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; uncharacterized protein 42160 34684238 LALA0_S02e00606g Lachancea lanzarotensis uncharacterized protein XP_022627070.1 40223 R 1245769 CDS LALA0_S02e00628g 34684239 44298..46283 Unknown 1 NW_019212880.1 weakly similar to uniprot|P53438 Saccharomyces cerevisiae YMR016C (ohnolog of YKL043W) SOK2 Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors; uncharacterized protein 46283 34684239 LALA0_S02e00628g Lachancea lanzarotensis uncharacterized protein XP_022627071.1 44298 D 1245769 CDS LALA0_S02e00650g 34684240 46838..47818 Unknown 1 NW_019212880.1 weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane; uncharacterized protein 47818 34684240 LALA0_S02e00650g Lachancea lanzarotensis uncharacterized protein XP_022627072.1 46838 D 1245769 CDS LALA0_S02e00672g 34684241 48248..49852 Unknown 1 NW_019212880.1 highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; C-22 sterol desaturase 49852 34684241 LALA0_S02e00672g Lachancea lanzarotensis C-22 sterol desaturase XP_022627073.1 48248 D 1245769 CDS LALA0_S02e00694g 34684242 complement(50010..51497) Unknown 1 NW_019212880.1 similar to uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern; uncharacterized protein 51497 34684242 LALA0_S02e00694g Lachancea lanzarotensis uncharacterized protein XP_022627074.1 50010 R 1245769 CDS LALA0_S02e00716g 34684243 54679..56181 Unknown 1 NW_019212880.1 similar to uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation; dolichol kinase 56181 34684243 LALA0_S02e00716g Lachancea lanzarotensis dolichol kinase XP_022627075.1 54679 D 1245769 CDS LALA0_S02e00738g 34684244 complement(56319..60023) Unknown 1 NW_019212880.1 similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W CLU1 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; translation initiation factor 3 subunit CLU1 60023 34684244 LALA0_S02e00738g Lachancea lanzarotensis translation initiation factor 3 subunit CLU1 XP_022627076.1 56319 R 1245769 CDS LALA0_S02e00782g 34684246 60827..61501 Unknown 1 NW_019212880.1 highly similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; ESCRT-III subunit protein VPS24 61501 34684246 LALA0_S02e00782g Lachancea lanzarotensis ESCRT-III subunit protein VPS24 XP_022627077.1 60827 D 1245769 CDS LALA0_S02e00804g 34684247 complement(61591..62904) Unknown 1 NW_019212880.1 weakly similar to uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; transcriptional regulator OPI1 62904 34684247 LALA0_S02e00804g Lachancea lanzarotensis transcriptional regulator OPI1 XP_022627078.1 61591 R 1245769 CDS LALA0_S02e00826g 34684248 63503..64903 Unknown 1 NW_019212880.1 similar to uniprot|C5DGR1 Lachancea thermotolerans KLTH0D07392g hypothetical protein; uncharacterized protein 64903 34684248 LALA0_S02e00826g Lachancea lanzarotensis uncharacterized protein XP_022627079.1 63503 D 1245769 CDS LALA0_S02e00848g 34684249 complement(65002..66558) Unknown 1 NW_019212880.1 similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; uncharacterized protein 66558 34684249 LALA0_S02e00848g Lachancea lanzarotensis uncharacterized protein XP_022627080.1 65002 R 1245769 CDS LALA0_S02e00870g 34684250 66686..67021 Unknown 1 NW_019212880.1 similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS; 4a-hydroxytetrahydrobiopterin dehydratase 67021 34684250 LALA0_S02e00870g Lachancea lanzarotensis 4a-hydroxytetrahydrobiopterin dehydratase XP_022627081.1 66686 D 1245769 CDS LALA0_S02e00892g 34684251 complement(67153..67896) Unknown 1 NW_019212880.1 similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C NFU1 Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria; uncharacterized protein 67896 34684251 LALA0_S02e00892g Lachancea lanzarotensis uncharacterized protein XP_022627082.1 67153 R 1245769 CDS LALA0_S02e00914g 34684252 68788..70266 Unknown 1 NW_019212880.1 similar to uniprot|P38745 Saccharomyces cerevisiae YHL017W (ohnolog of YKL039W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; uncharacterized protein 70266 34684252 LALA0_S02e00914g Lachancea lanzarotensis uncharacterized protein XP_022627083.1 68788 D 1245769 CDS LALA0_S02e00936g 34684253 complement(70774..72933) Unknown 1 NW_019212880.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; uncharacterized protein 72933 34684253 LALA0_S02e00936g Lachancea lanzarotensis uncharacterized protein XP_022627084.1 70774 R 1245769 CDS LALA0_S02e00958g 34684254 complement(73820..75166) Unknown 1 NW_019212880.1 similar to uniprot|C5DGP5 Lachancea thermotolerans KLTH0D06996g hypothetical protein; uncharacterized protein 75166 34684254 LALA0_S02e00958g Lachancea lanzarotensis uncharacterized protein XP_022627085.1 73820 R 1245769 CDS LALA0_S02e00980g 34684255 76202..76558 Unknown 1 NW_019212880.1 highly similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins; 40S ribosomal protein uS10 76558 34684255 LALA0_S02e00980g Lachancea lanzarotensis 40S ribosomal protein uS10 XP_022627086.1 76202 D 1245769 CDS LALA0_S02e01002g 34684256 complement(77451..78704) Unknown 1 NW_019212880.1 similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 78704 34684256 LALA0_S02e01002g Lachancea lanzarotensis uncharacterized protein XP_022627087.1 77451 R 1245769 CDS LALA0_S02e01024g 34684257 complement(78795..79754) Unknown 1 NW_019212880.1 similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C OTU2 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; uncharacterized protein 79754 34684257 LALA0_S02e01024g Lachancea lanzarotensis uncharacterized protein XP_022627088.1 78795 R 1245769 CDS LALA0_S02e01068g 34684259 80547..83477 Unknown 1 NW_019212880.1 weakly similar to uniprot|P32862 Saccharomyces cerevisiae YKL038W (ohnolog of YBR033W EDS1) RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; uncharacterized protein 83477 34684259 LALA0_S02e01068g Lachancea lanzarotensis uncharacterized protein XP_022627089.1 80547 D 1245769 CDS LALA0_S02e01090g 34684260 84058..85560 Unknown 1 NW_019212880.1 highly similar to uniprot|P38709 Saccharomyces cerevisiae YHL012W (ohnolog of YKL035W) Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase; uncharacterized protein 85560 34684260 LALA0_S02e01090g Lachancea lanzarotensis uncharacterized protein XP_022627090.1 84058 D 1245769 CDS LALA0_S02e01112g 34684261 86633..88888 Unknown 1 NW_019212880.1 similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes; ubiquitin-protein ligase TUL1 88888 34684261 LALA0_S02e01112g Lachancea lanzarotensis ubiquitin-protein ligase TUL1 XP_022627091.1 86633 D 1245769 CDS LALA0_S02e01134g 34684262 89165..89836 Unknown 1 NW_019212880.1 similar to uniprot|Q86ZR7 Saccharomyces cerevisiae YKL033W-A Putative protein of unknown function; similar to uncharacterized proteins from other fungi; uncharacterized protein 89836 34684262 LALA0_S02e01134g Lachancea lanzarotensis uncharacterized protein XP_022627092.1 89165 D 1245769 CDS LALA0_S02e01156g 34684263 complement(89939..90901) Unknown 1 NW_019212880.1 highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS3 90901 34684263 LALA0_S02e01156g Lachancea lanzarotensis ribose phosphate diphosphokinase subunit PRS3 XP_022627093.1 89939 R 1245769 CDS LALA0_S02e01178g 34684264 complement(91469..93061) Unknown 1 NW_019212880.1 similar to uniprot|P38748 Saccharomyces cerevisiae YHL010C ETP1 Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences; uncharacterized protein 93061 34684264 LALA0_S02e01178g Lachancea lanzarotensis uncharacterized protein XP_022627094.1 91469 R 1245769 CDS LALA0_S02e01200g 34684265 94531..96168 Unknown 1 NW_019212880.1 weakly similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease; one of threeamino acid permeases (Alp1p, Can1p, Lyp1p) responsible foruptake of cationic amino acids; uncharacterized protein 96168 34684265 LALA0_S02e01200g Lachancea lanzarotensis uncharacterized protein XP_022627095.1 94531 D 1245769 CDS LALA0_S02e01222g 34684266 96432..99563 Unknown 1 NW_019212880.1 similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W TTI1 Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 99563 34684266 LALA0_S02e01222g Lachancea lanzarotensis uncharacterized protein XP_022627096.1 96432 D 1245769 CDS LALA0_S02e01244g 34684267 99839..101719 Unknown 1 NW_019212880.1 similar to uniprot|P38750 Saccharomyces cerevisiae YHL008C Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; uncharacterized protein 101719 34684267 LALA0_S02e01244g Lachancea lanzarotensis uncharacterized protein XP_022627097.1 99839 D 1245769 CDS LALA0_S02e01266g 34684268 102144..105947 Unknown 1 NW_019212880.1 similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis; uncharacterized protein 105947 34684268 LALA0_S02e01266g Lachancea lanzarotensis uncharacterized protein XP_022627098.1 102144 D 1245769 CDS LALA0_S02e01288g 34684269 complement(106026..107984) Unknown 1 NW_019212880.1 similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p; uncharacterized protein 107984 34684269 LALA0_S02e01288g Lachancea lanzarotensis uncharacterized protein XP_022627099.1 106026 R 1245769 CDS LALA0_S02e01310g 34684270 join(109439..109533,109607..109934) Unknown 1 NW_019212880.1 similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; uncharacterized protein 109934 34684270 LALA0_S02e01310g Lachancea lanzarotensis uncharacterized protein XP_022627100.1 109439 D 1245769 CDS LALA0_S02e01332g 34684271 110564..112627 Unknown 1 NW_019212880.1 highly similar to uniprot|C5DGP1 Lachancea thermotolerans KLTH0D06886g hypothetical protein; uncharacterized protein 112627 34684271 LALA0_S02e01332g Lachancea lanzarotensis uncharacterized protein XP_022627101.1 110564 D 1245769 CDS LALA0_S02e01354g 34684272 112984..113541 Unknown 1 NW_019212880.1 similar to uniprot|Q04772 Saccharomyces cerevisiae YMR073C IRC21 Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study; uncharacterized protein 113541 34684272 LALA0_S02e01354g Lachancea lanzarotensis uncharacterized protein XP_022627102.1 112984 D 1245769 CDS LALA0_S02e01376g 34684273 complement(113809..115194) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q02486 Saccharomyces cerevisiae YMR072W (ohnolog of YKL032C) ABF2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; uncharacterized protein 115194 34684273 LALA0_S02e01376g Lachancea lanzarotensis uncharacterized protein XP_022627103.1 113809 R 1245769 CDS LALA0_S02e01398g 34684274 complement(117242..119278) Unknown 1 NW_019212880.1 similar to uniprot|C5DGJ9 Lachancea thermotolerans KLTH0D05940g hypothetical protein; uncharacterized protein 119278 34684274 LALA0_S02e01398g Lachancea lanzarotensis uncharacterized protein XP_022627104.1 117242 R 1245769 CDS LALA0_S02e01420g 34684275 join(119569..119639,119725..120157) Unknown 1 NW_019212880.1 highly similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; uncharacterized protein 120157 34684275 LALA0_S02e01420g Lachancea lanzarotensis uncharacterized protein XP_022627105.1 119569 D 1245769 CDS LALA0_S02e01442g 34684276 complement(120407..121735) Unknown 1 NW_019212880.1 weakly similar to uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; can form the [MOT3+] prion; uncharacterized protein 121735 34684276 LALA0_S02e01442g Lachancea lanzarotensis uncharacterized protein XP_022627106.1 120407 R 1245769 CDS LALA0_S02e01464g 34684277 complement(122606..123379) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A; uncharacterized protein 123379 34684277 LALA0_S02e01464g Lachancea lanzarotensis uncharacterized protein XP_022627107.1 122606 R 1245769 CDS LALA0_S02e01486g 34684278 126123..127244 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12145 Saccharomyces cerevisiae YPR013C Putative zinc finger protein; YPR013C is not an essential gene; uncharacterized protein 127244 34684278 LALA0_S02e01486g Lachancea lanzarotensis uncharacterized protein XP_022627108.1 126123 D 1245769 CDS LALA0_S02e01508g 34684279 128548..129846 Unknown 1 NW_019212880.1 similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard; Nem1-Spo7 phosphatase catalytic subunit NEM1 129846 34684279 LALA0_S02e01508g Lachancea lanzarotensis Nem1-Spo7 phosphatase catalytic subunit NEM1 XP_022627109.1 128548 D 1245769 CDS LALA0_S02e01530g 34684280 130854..133361 Unknown 1 NW_019212880.1 similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; oligopeptide transporter OPT1 133361 34684280 LALA0_S02e01530g Lachancea lanzarotensis oligopeptide transporter OPT1 XP_022627110.1 130854 D 1245769 CDS LALA0_S02e01552g 34684281 complement(133706..135661) Unknown 1 NW_019212880.1 highly similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; malate dehydrogenase (oxaloacetate-decarboxylating) 135661 34684281 LALA0_S02e01552g Lachancea lanzarotensis malate dehydrogenase (oxaloacetate-decarboxylating) XP_022627111.1 133706 R 1245769 CDS LALA0_S02e01574g 34684282 137759..139159 Unknown 1 NW_019212880.1 similar to uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening; transcription factor TFIIE subunit TFA1 139159 34684282 LALA0_S02e01574g Lachancea lanzarotensis transcription factor TFIIE subunit TFA1 XP_022627112.1 137759 D 1245769 CDS LALA0_S02e01596g 34684283 139293..140636 Unknown 1 NW_019212880.1 similar to uniprot|P38756 Saccharomyces cerevisiae YHR003C (ohnolog of YKL027W) Protein of unknown function, localized to the mitochondrial outer membrane; tRNA threonylcarbamoyladenosine dehydratase 140636 34684283 LALA0_S02e01596g Lachancea lanzarotensis tRNA threonylcarbamoyladenosine dehydratase XP_022627113.1 139293 D 1245769 CDS LALA0_S02e01618g 34684284 complement(140716..141765) Unknown 1 NW_019212880.1 similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized; coenzyme A transporter 141765 34684284 LALA0_S02e01618g Lachancea lanzarotensis coenzyme A transporter XP_022627114.1 140716 R 1245769 CDS LALA0_S02e01640g 34684285 143263..144159 Unknown 1 NW_019212880.1 highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family; uncharacterized protein 144159 34684285 LALA0_S02e01640g Lachancea lanzarotensis uncharacterized protein XP_022627115.1 143263 D 1245769 CDS LALA0_S02e01662g 34684286 complement(144331..145182) Unknown 1 NW_019212880.1 similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; uncharacterized protein 145182 34684286 LALA0_S02e01662g Lachancea lanzarotensis uncharacterized protein XP_022627116.1 144331 R 1245769 CDS LALA0_S02e01684g 34684287 complement(145432..147837) Unknown 1 NW_019212880.1 similar to uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; uncharacterized protein 147837 34684287 LALA0_S02e01684g Lachancea lanzarotensis uncharacterized protein XP_022627117.1 145432 R 1245769 CDS LALA0_S02e01728g 34684289 149265..150674 Unknown 1 NW_019212880.1 similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; uncharacterized protein 150674 34684289 LALA0_S02e01728g Lachancea lanzarotensis uncharacterized protein XP_022627118.1 149265 D 1245769 CDS LALA0_S02e01750g 34684290 151056..153746 Unknown 1 NW_019212880.1 highly similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 153746 34684290 LALA0_S02e01750g Lachancea lanzarotensis bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 XP_022627119.1 151056 D 1245769 CDS LALA0_S02e01772g 34684291 complement(154016..154243) Unknown 1 NW_019212880.1 similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain; 154243 34684291 LALA0_S02e01772g Lachancea lanzarotensis 154016 R 1245769 CDS LALA0_S02e01816g 34684292 complement(156892..158550) Unknown 1 NW_019212880.1 similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p; uncharacterized protein 158550 34684292 LALA0_S02e01816g Lachancea lanzarotensis uncharacterized protein XP_022627120.1 156892 R 1245769 CDS LALA0_S02e01838g 34684293 complement(158756..159205) Unknown 1 NW_019212880.1 similar to uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification; uncharacterized protein 159205 34684293 LALA0_S02e01838g Lachancea lanzarotensis uncharacterized protein XP_022627121.1 158756 R 1245769 CDS LALA0_S02e01860g 34684294 160036..160779 Unknown 1 NW_019212880.1 similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation; uncharacterized protein 160779 34684294 LALA0_S02e01860g Lachancea lanzarotensis uncharacterized protein XP_022627122.1 160036 D 1245769 CDS LALA0_S02e01882g 34684295 join(161334..161553,161606..162549) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function; uncharacterized protein 162549 34684295 LALA0_S02e01882g Lachancea lanzarotensis uncharacterized protein XP_022627123.1 161334 D 1245769 CDS LALA0_S02e01904g 34684296 complement(162599..163903) Unknown 1 NW_019212880.1 highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W (ohnolog of YKR003W) OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; oxysterol-binding protein OSH6 163903 34684296 LALA0_S02e01904g Lachancea lanzarotensis oxysterol-binding protein OSH6 XP_022627124.1 162599 R 1245769 CDS LALA0_S02e01926g 34684297 complement(164250..166040) Unknown 1 NW_019212880.1 similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping; polynucleotide adenylyltransferase PAP1 166040 34684297 LALA0_S02e01926g Lachancea lanzarotensis polynucleotide adenylyltransferase PAP1 XP_022627125.1 164250 R 1245769 CDS LALA0_S02e01948g 34684298 166505..168565 Unknown 1 NW_019212880.1 highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis; dynamin-like GTPase VPS1 168565 34684298 LALA0_S02e01948g Lachancea lanzarotensis dynamin-like GTPase VPS1 XP_022627126.1 166505 D 1245769 CDS LALA0_S02e01992g 34684299 join(169230..169342,169400..169883) Unknown 1 NW_019212880.1 highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism; adenylyl-sulfate kinase 169883 34684299 LALA0_S02e01992g Lachancea lanzarotensis adenylyl-sulfate kinase XP_022627127.1 169230 D 1245769 CDS LALA0_S02e02014g 34684300 complement(join(169910..170539,170599..170658)) Unknown 1 NW_019212880.1 highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; ESCRT-III subunit protein DID4 170658 34684300 LALA0_S02e02014g Lachancea lanzarotensis ESCRT-III subunit protein DID4 XP_022627128.1 169910 R 1245769 CDS LALA0_S02e02036g 34684301 170861..171250 Unknown 1 NW_019212880.1 similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator; mitochondrial 37S ribosomal protein bS6m 171250 34684301 LALA0_S02e02036g Lachancea lanzarotensis mitochondrial 37S ribosomal protein bS6m XP_022627129.1 170861 D 1245769 CDS LALA0_S02e02058g 34684302 complement(171409..172653) Unknown 1 NW_019212880.1 similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; inositol phosphorylceramide synthase 172653 34684302 LALA0_S02e02058g Lachancea lanzarotensis inositol phosphorylceramide synthase XP_022627130.1 171409 R 1245769 CDS LALA0_S02e02080g 34684303 174464..176104 Unknown 1 NW_019212880.1 weakly similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit; uncharacterized protein 176104 34684303 LALA0_S02e02080g Lachancea lanzarotensis uncharacterized protein XP_022627131.1 174464 D 1245769 CDS LALA0_S02e02102g 34684304 complement(join(176383..176670,176901..177029)) Unknown 1 NW_019212880.1 highly similar to uniprot|P38754 Saccharomyces cerevisiae YHL001W (ohnolog of YKL006W) RPL14B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein; 60S ribosomal protein eL14 177029 34684304 LALA0_S02e02102g Lachancea lanzarotensis 60S ribosomal protein eL14 XP_022627132.1 176383 R 1245769 CDS LALA0_S02e02124g 34684305 join(178166..178201,178268..178525) Unknown 1 NW_019212880.1 highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment; uncharacterized protein 178525 34684305 LALA0_S02e02124g Lachancea lanzarotensis uncharacterized protein XP_022627133.1 178166 D 1245769 CDS LALA0_S02e02146g 34684306 complement(178605..179402) Unknown 1 NW_019212880.1 similar to uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; uncharacterized protein 179402 34684306 LALA0_S02e02146g Lachancea lanzarotensis uncharacterized protein XP_022627134.1 178605 R 1245769 CDS LALA0_S02e02168g 34684307 complement(179678..181147) Unknown 1 NW_019212880.1 similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes; ESCRT-0 subunit protein HSE1 181147 34684307 LALA0_S02e02168g Lachancea lanzarotensis ESCRT-0 subunit protein HSE1 XP_022627135.1 179678 R 1245769 CDS LALA0_S02e02190g 34684308 182087..183331 Unknown 1 NW_019212880.1 similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C (ohnolog of YKL008C) LAG1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; uncharacterized protein 183331 34684308 LALA0_S02e02190g Lachancea lanzarotensis uncharacterized protein XP_022627136.1 182087 D 1245769 CDS LALA0_S02e02212g 34684309 complement(183521..184747) Unknown 1 NW_019212880.1 similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS2m 184747 34684309 LALA0_S02e02212g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS2m XP_022627137.1 183521 R 1245769 CDS LALA0_S02e02234g 34684310 184998..185465 Unknown 1 NW_019212880.1 weakly similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p; uncharacterized protein 185465 34684310 LALA0_S02e02234g Lachancea lanzarotensis uncharacterized protein XP_022627138.1 184998 D 1245769 CDS LALA0_S02e02256g 34684311 complement(185529..186236) Unknown 1 NW_019212880.1 highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus; uncharacterized protein 186236 34684311 LALA0_S02e02256g Lachancea lanzarotensis uncharacterized protein XP_022627139.1 185529 R 1245769 CDS LALA0_S02e02278g 34684312 187462..191811 Unknown 1 NW_019212880.1 similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; uncharacterized protein 191811 34684312 LALA0_S02e02278g Lachancea lanzarotensis uncharacterized protein XP_022627140.1 187462 D 1245769 CDS LALA0_S02e02300g 34684313 192323..195187 Unknown 1 NW_019212880.1 some similarities with uniprot|Q12469 Saccharomyces cerevisiae YOL113W (ohnolog of YNL298W) SKM1 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; mitogen-activated protein kinase kinase kinase kinase STE20 195187 34684313 LALA0_S02e02300g Lachancea lanzarotensis mitogen-activated protein kinase kinase kinase kinase STE20 XP_022627141.1 192323 D 1245769 CDS LALA0_S02e02322g 34684314 complement(195367..197118) Unknown 1 NW_019212880.1 similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p; uncharacterized protein 197118 34684314 LALA0_S02e02322g Lachancea lanzarotensis uncharacterized protein XP_022627142.1 195367 R 1245769 CDS LALA0_S02e02344g 34684315 complement(197272..198603) Unknown 1 NW_019212880.1 weakly similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination; uncharacterized protein 198603 34684315 LALA0_S02e02344g Lachancea lanzarotensis uncharacterized protein XP_022627143.1 197272 R 1245769 CDS LALA0_S02e02366g 34684316 complement(198776..199486) Unknown 1 NW_019212880.1 similar to uniprot|C5DGG9 Lachancea thermotolerans KLTH0D05236g hypothetical protein; uncharacterized protein 199486 34684316 LALA0_S02e02366g Lachancea lanzarotensis uncharacterized protein XP_022627144.1 198776 R 1245769 CDS LALA0_S02e02388g 34684317 complement(199712..200614) Unknown 1 NW_019212880.1 weakly similar to uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 Basic leucine zipper (bZIP) transcription factor; uncharacterized protein 200614 34684317 LALA0_S02e02388g Lachancea lanzarotensis uncharacterized protein XP_022627145.1 199712 R 1245769 CDS LALA0_S02e02432g 34684319 complement(201392..203506) Unknown 1 NW_019212880.1 similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; uncharacterized protein 203506 34684319 LALA0_S02e02432g Lachancea lanzarotensis uncharacterized protein XP_022627146.1 201392 R 1245769 CDS LALA0_S02e02454g 34684320 join(204373..204381,204943..205839) Unknown 1 NW_019212880.1 highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W (ohnolog of YKL091C) SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs; uncharacterized protein 205839 34684320 LALA0_S02e02454g Lachancea lanzarotensis uncharacterized protein XP_022627147.1 204373 D 1245769 CDS LALA0_S02e02476g 34684321 206079..209240 Unknown 1 NW_019212880.1 similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; GTPase-activating protein BUD2 209240 34684321 LALA0_S02e02476g Lachancea lanzarotensis GTPase-activating protein BUD2 XP_022627148.1 206079 D 1245769 CDS LALA0_S02e02498g 34684322 complement(209379..212300) Unknown 1 NW_019212880.1 highly similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; ATP-dependent RNA helicase NAM7 212300 34684322 LALA0_S02e02498g Lachancea lanzarotensis ATP-dependent RNA helicase NAM7 XP_022627149.1 209379 R 1245769 CDS LALA0_S02e02520g 34684323 complement(212902..213762) Unknown 1 NW_019212880.1 weakly similar to uniprot|P32488 Saccharomyces cerevisiae YMR081C (ohnolog of YKL093W) ISF1 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; uncharacterized protein 213762 34684323 LALA0_S02e02520g Lachancea lanzarotensis uncharacterized protein XP_022627150.1 212902 R 1245769 CDS LALA0_S02e02542g 34684324 complement(214353..215387) Unknown 1 NW_019212880.1 similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family; acylglycerol lipase 215387 34684324 LALA0_S02e02542g Lachancea lanzarotensis acylglycerol lipase XP_022627151.1 214353 R 1245769 CDS LALA0_S02e02564g 34684325 complement(215675..216466) Unknown 1 NW_019212880.1 similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing; mRNA splicing protein YJU2 216466 34684325 LALA0_S02e02564g Lachancea lanzarotensis mRNA splicing protein YJU2 XP_022627152.1 215675 R 1245769 CDS LALA0_S02e02586g 34684326 complement(216923..219421) Unknown 1 NW_019212880.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance; uncharacterized protein 219421 34684326 LALA0_S02e02586g Lachancea lanzarotensis uncharacterized protein XP_022627153.1 216923 R 1245769 CDS LALA0_S02e02608g 34684327 complement(220444..221706) Unknown 1 NW_019212880.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance; uncharacterized protein 221706 34684327 LALA0_S02e02608g Lachancea lanzarotensis uncharacterized protein XP_022627154.1 220444 R 1245769 CDS LALA0_S02e02630g 34684328 complement(222200..223057) Unknown 1 NW_019212880.1 weakly similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W MTC2 Protein of unknown function; mtc2 is synthetically sick with cdc13-1; uncharacterized protein 223057 34684328 LALA0_S02e02630g Lachancea lanzarotensis uncharacterized protein XP_022627155.1 222200 R 1245769 CDS LALA0_S02e02652g 34684329 224081..224851 Unknown 1 NW_019212880.1 similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; rRNA-processing protein UTP11 224851 34684329 LALA0_S02e02652g Lachancea lanzarotensis rRNA-processing protein UTP11 XP_022627156.1 224081 D 1245769 CDS LALA0_S02e02674g 34684330 225573..226739 Unknown 1 NW_019212880.1 highly similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 Mitochondrial alcoholdehydrogenase isozyme III; involved in the shuttling ofmitochondrial NADH to the cytosol under anaerobicconditions and ethanol production; alcohol dehydrogenase ADH3 226739 34684330 LALA0_S02e02674g Lachancea lanzarotensis alcohol dehydrogenase ADH3 XP_022627157.1 225573 D 1245769 CDS LALA0_S02e02696g 34684331 complement(226972..230631) Unknown 1 NW_019212880.1 similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p; protein kinase HSL1 230631 34684331 LALA0_S02e02696g Lachancea lanzarotensis protein kinase HSL1 XP_022627158.1 226972 R 1245769 CDS LALA0_S02e02718g 34684332 232393..233943 Unknown 1 NW_019212880.1 similar to uniprot|P14904 Saccharomyces cerevisiae YKL103C LAP4 Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; metalloaminopeptidase APE1 233943 34684332 LALA0_S02e02718g Lachancea lanzarotensis metalloaminopeptidase APE1 XP_022627159.1 232393 D 1245769 CDS LALA0_S02e02740g 34684333 236287..238395 Unknown 1 NW_019212880.1 highly similar to uniprot|A2P2R3 Saccharomyces cerevisiae YMR084W (ohnolog of YKL104C) Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains; glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 238395 34684333 LALA0_S02e02740g Lachancea lanzarotensis glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 XP_022627160.1 236287 D 1245769 CDS LALA0_S02e02762g 34684334 239976..242204 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04279 Saccharomyces cerevisiae YMR086W (ohnolog of YKL105C) Component of the eisosome with unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; expression is repressed by cAMP; similar to A. gossypii SEG gene which is important for stabilizing eisosomes; uncharacterized protein 242204 34684334 LALA0_S02e02762g Lachancea lanzarotensis uncharacterized protein XP_022627161.1 239976 D 1245769 CDS LALA0_S02e02784g 34684335 complement(242299..243567) Unknown 1 NW_019212880.1 similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; aspartate transaminase AAT1 243567 34684335 LALA0_S02e02784g Lachancea lanzarotensis aspartate transaminase AAT1 XP_022627162.1 242299 R 1245769 CDS LALA0_S02e02806g 34684336 243839..244669 Unknown 1 NW_019212880.1 similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain; uncharacterized protein 244669 34684336 LALA0_S02e02806g Lachancea lanzarotensis uncharacterized protein XP_022627163.1 243839 D 1245769 CDS LALA0_S02e02828g 34684337 complement(244568..246298) Unknown 1 NW_019212880.1 similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 246298 34684337 LALA0_S02e02828g Lachancea lanzarotensis uncharacterized protein XP_022627164.1 244568 R 1245769 CDS LALA0_S02e02850g 34684338 complement(246802..249288) Unknown 1 NW_019212880.1 highly similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; m-AAA protease subunit YTA12 249288 34684338 LALA0_S02e02850g Lachancea lanzarotensis m-AAA protease subunit YTA12 XP_022627165.1 246802 R 1245769 CDS LALA0_S02e02872g 34684339 complement(249585..250937) Unknown 1 NW_019212880.1 similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length; uncharacterized protein 250937 34684339 LALA0_S02e02872g Lachancea lanzarotensis uncharacterized protein XP_022627166.1 249585 R 1245769 CDS LALA0_S02e02894g 34684340 complement(251377..253224) Unknown 1 NW_019212880.1 similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; uncharacterized protein 253224 34684340 LALA0_S02e02894g Lachancea lanzarotensis uncharacterized protein XP_022627167.1 251377 R 1245769 CDS LALA0_S02e02916g 34684341 254078..255604 Unknown 1 NW_019212880.1 highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein UTP15 255604 34684341 LALA0_S02e02916g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein UTP15 XP_022627168.1 254078 D 1245769 CDS LALA0_S02e02938g 34684342 complement(255694..256710) Unknown 1 NW_019212880.1 weakly similar to uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; required for the S phase checkpoint; uncharacterized protein 256710 34684342 LALA0_S02e02938g Lachancea lanzarotensis uncharacterized protein XP_022627169.1 255694 R 1245769 CDS LALA0_S02e02960g 34684343 256905..258059 Unknown 1 NW_019212880.1 weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis; uncharacterized protein 258059 34684343 LALA0_S02e02960g Lachancea lanzarotensis uncharacterized protein XP_022627170.1 256905 D 1245769 CDS LALA0_S02e02982g 34684344 complement(258054..258707) Unknown 1 NW_019212880.1 similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin; uncharacterized protein 258707 34684344 LALA0_S02e02982g Lachancea lanzarotensis uncharacterized protein XP_022627171.1 258054 R 1245769 CDS LALA0_S02e03004g 34684345 259797..260684 Unknown 1 NW_019212880.1 highly similar to uniprot|P53824 Saccharomyces cerevisiae YNL333W Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p; pyridoxine biosynthesis protein SNZ1 260684 34684345 LALA0_S02e03004g Lachancea lanzarotensis pyridoxine biosynthesis protein SNZ1 XP_022627172.1 259797 D 1245769 CDS LALA0_S02e03026g 34684346 complement(261121..263019) Unknown 1 NW_019212880.1 similar to uniprot|C5DFT5 Lachancea thermotolerans KLTH0D17776g hypothetical protein; transcription factor HAP4 263019 34684346 LALA0_S02e03026g Lachancea lanzarotensis transcription factor HAP4 XP_022627173.1 261121 R 1245769 CDS LALA0_S02e03048g 34684347 complement(263826..264971) Unknown 1 NW_019212880.1 similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals; uncharacterized protein 264971 34684347 LALA0_S02e03048g Lachancea lanzarotensis uncharacterized protein XP_022627174.1 263826 R 1245769 CDS LALA0_S02e03070g 34684348 265209..266141 Unknown 1 NW_019212880.1 similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p; uncharacterized protein 266141 34684348 LALA0_S02e03070g Lachancea lanzarotensis uncharacterized protein XP_022627175.1 265209 D 1245769 CDS LALA0_S02e03092g 34684349 complement(266196..267986) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C ATP25 Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene; uncharacterized protein 267986 34684349 LALA0_S02e03092g Lachancea lanzarotensis uncharacterized protein XP_022627176.1 266196 R 1245769 CDS LALA0_S02e03114g 34684350 complement(268709..270109) Unknown 1 NW_019212880.1 some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair; DNA-binding protein ABF1 270109 34684350 LALA0_S02e03114g Lachancea lanzarotensis DNA-binding protein ABF1 XP_022627177.1 268709 R 1245769 CDS LALA0_S02e03136g 34684351 274838..275986 Unknown 1 NW_019212880.1 highly similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family; multifunctional nuclease RAD27 275986 34684351 LALA0_S02e03136g Lachancea lanzarotensis multifunctional nuclease RAD27 XP_022627178.1 274838 D 1245769 CDS LALA0_S02e03158g 34684352 276202..277347 Unknown 1 NW_019212880.1 similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; DNA-(apurinic or apyrimidinic site) lyase APN1 277347 34684352 LALA0_S02e03158g Lachancea lanzarotensis DNA-(apurinic or apyrimidinic site) lyase APN1 XP_022627179.1 276202 D 1245769 CDS LALA0_S02e03180g 34684353 277618..279204 Unknown 1 NW_019212880.1 similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; serine/threonine protein kinase PRR1 279204 34684353 LALA0_S02e03180g Lachancea lanzarotensis serine/threonine protein kinase PRR1 XP_022627180.1 277618 D 1245769 CDS LALA0_S02e03202g 34684354 279509..280399 Unknown 1 NW_019212880.1 highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS; glucose-6-phosphate 1-epimerase 280399 34684354 LALA0_S02e03202g Lachancea lanzarotensis glucose-6-phosphate 1-epimerase XP_022627181.1 279509 D 1245769 CDS LALA0_S02e03224g 34684355 complement(280540..281103) Unknown 1 NW_019212880.1 similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W SBA1 Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity; Hsp90 cochaperone SBA1 281103 34684355 LALA0_S02e03224g Lachancea lanzarotensis Hsp90 cochaperone SBA1 XP_022627182.1 280540 R 1245769 CDS LALA0_S02e03246g 34684356 282026..283546 Unknown 1 NW_019212880.1 similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases; uncharacterized protein 283546 34684356 LALA0_S02e03246g Lachancea lanzarotensis uncharacterized protein XP_022627183.1 282026 D 1245769 CDS LALA0_S02e03268g 34684357 complement(283730..284128) Unknown 1 NW_019212880.1 similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm; signal recognition particle subunit SRP21 284128 34684357 LALA0_S02e03268g Lachancea lanzarotensis signal recognition particle subunit SRP21 XP_022627184.1 283730 R 1245769 CDS LALA0_S02e03290g 34684358 286433..288694 Unknown 1 NW_019212880.1 similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C (ohnolog of YKL121W) Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene; uncharacterized protein 288694 34684358 LALA0_S02e03290g Lachancea lanzarotensis uncharacterized protein XP_022627185.1 286433 D 1245769 CDS LALA0_S02e03312g 34684359 289208..290185 Unknown 1 NW_019212880.1 highly similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family; uncharacterized protein 290185 34684359 LALA0_S02e03312g Lachancea lanzarotensis uncharacterized protein XP_022627186.1 289208 D 1245769 CDS LALA0_S02e03334g 34684360 291112..292203 Unknown 1 NW_019212880.1 similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase; ditrans,polycis-polyprenyl diphosphate synthase 292203 34684360 LALA0_S02e03334g Lachancea lanzarotensis ditrans,polycis-polyprenyl diphosphate synthase XP_022627187.1 291112 D 1245769 CDS LALA0_S02e03356g 34684361 complement(292223..292828) Unknown 1 NW_019212880.1 similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); uncharacterized protein 292828 34684361 LALA0_S02e03356g Lachancea lanzarotensis uncharacterized protein XP_022627188.1 292223 R 1245769 CDS LALA0_S02e03378g 34684362 293016..294728 Unknown 1 NW_019212880.1 similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W MUB1 MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene; uncharacterized protein 294728 34684362 LALA0_S02e03378g Lachancea lanzarotensis uncharacterized protein XP_022627189.1 293016 D 1245769 CDS LALA0_S02e03400g 34684363 complement(join(294928..296625,296697..296891)) Unknown 1 NW_019212880.1 similar to uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; rDNA-binding RNA polymerase I transcriptional factor 296891 34684363 LALA0_S02e03400g Lachancea lanzarotensis rDNA-binding RNA polymerase I transcriptional factor XP_022627190.1 294928 R 1245769 CDS LALA0_S02e03422g 34684364 complement(297787..299931) Unknown 1 NW_019212880.1 similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C (ohnolog of YKL126W) YPK2 Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; serine/threonine protein kinase YPK1 299931 34684364 LALA0_S02e03422g Lachancea lanzarotensis serine/threonine protein kinase YPK1 XP_022627191.1 297787 R 1245769 CDS LALA0_S02e03444g 34684365 complement(300354..302066) Unknown 1 NW_019212880.1 highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C (ohnolog of YKL127W) PGM2 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; uncharacterized protein 302066 34684365 LALA0_S02e03444g Lachancea lanzarotensis uncharacterized protein XP_022627192.1 300354 R 1245769 CDS LALA0_S02e03466g 34684366 complement(302407..304278) Unknown 1 NW_019212880.1 similar to uniprot|Q04437 Saccharomyces cerevisiae YMR106C YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; ATP-dependent DNA helicase YKU80 304278 34684366 LALA0_S02e03466g Lachancea lanzarotensis ATP-dependent DNA helicase YKU80 XP_022627193.1 302407 R 1245769 CDS LALA0_S02e03510g 34684368 complement(304793..307120) Unknown 1 NW_019212880.1 similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C 37165 Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis; metalloendopeptidase 307120 34684368 LALA0_S02e03510g Lachancea lanzarotensis metalloendopeptidase XP_022627194.1 304793 R 1245769 CDS LALA0_S02e03532g 34684369 complement(307298..308731) Unknown 1 NW_019212880.1 similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W (ohnolog of YKL133C) MGR3 Subunit of themitochondrial (mt) i-AAA protease supercomplex, whichdegrades misfolded mitochondrial proteins; forms asubcomplex with Mgr1p that binds to substrates tofacilitate proteolysis; required for growth of cellslacking mtDNA; uncharacterized protein 308731 34684369 LALA0_S02e03532g Lachancea lanzarotensis uncharacterized protein XP_022627195.1 307298 R 1245769 CDS LALA0_S02e03554g 34684370 309446..310498 Unknown 1 NW_019212880.1 similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene; uncharacterized protein 310498 34684370 LALA0_S02e03554g Lachancea lanzarotensis uncharacterized protein XP_022627196.1 309446 D 1245769 CDS LALA0_S02e03576g 34684371 complement(310503..311774) Unknown 1 NW_019212880.1 similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W (ohnolog of YKL132C) FOL3 Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; dihydrofolate synthase 311774 34684371 LALA0_S02e03576g Lachancea lanzarotensis dihydrofolate synthase XP_022627197.1 310503 R 1245769 CDS LALA0_S02e03598g 34684372 312042..312389 Unknown 1 NW_019212880.1 similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein; uncharacterized protein 312389 34684372 LALA0_S02e03598g Lachancea lanzarotensis uncharacterized protein XP_022627198.1 312042 D 1245769 CDS LALA0_S02e03620g 34684373 312762..313970 Unknown 1 NW_019212880.1 similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains; uncharacterized protein 313970 34684373 LALA0_S02e03620g Lachancea lanzarotensis uncharacterized protein XP_022627199.1 312762 D 1245769 CDS LALA0_S02e03642g 34684374 314390..315541 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; uncharacterized protein 315541 34684374 LALA0_S02e03642g Lachancea lanzarotensis uncharacterized protein XP_022627200.1 314390 D 1245769 CDS LALA0_S02e03664g 34684375 complement(315641..316354) Unknown 1 NW_019212880.1 similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; uncharacterized protein 316354 34684375 LALA0_S02e03664g Lachancea lanzarotensis uncharacterized protein XP_022627201.1 315641 R 1245769 CDS LALA0_S02e03686g 34684376 317572..317751 Unknown 1 NW_019212880.1 similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms; F1F0 ATP synthase subunit i 317751 34684376 LALA0_S02e03686g Lachancea lanzarotensis F1F0 ATP synthase subunit i XP_022627202.1 317572 D 1245769 CDS LALA0_S02e03708g 34684377 complement(318025..319965) Unknown 1 NW_019212880.1 similar to uniprot|Q04533 Saccharomyces cerevisiae YML082W (ohnolog of YJR130C) Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene; cystathionine gamma-synthase 319965 34684377 LALA0_S02e03708g Lachancea lanzarotensis cystathionine gamma-synthase XP_022627203.1 318025 R 1245769 CDS LALA0_S02e03730g 34684378 321048..321893 Unknown 1 NW_019212880.1 weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; uncharacterized protein 321893 34684378 LALA0_S02e03730g Lachancea lanzarotensis uncharacterized protein XP_022627204.1 321048 D 1245769 CDS LALA0_S02e03752g 34684379 323100..324737 Unknown 1 NW_019212880.1 similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase 324737 34684379 LALA0_S02e03752g Lachancea lanzarotensis mannosyl-oligosaccharide 1,2-alpha-mannosidase XP_022627205.1 323100 D 1245769 CDS LALA0_S02e03774g 34684380 complement(324822..325211) Unknown 1 NW_019212880.1 similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; uncharacterized protein 325211 34684380 LALA0_S02e03774g Lachancea lanzarotensis uncharacterized protein XP_022627206.1 324822 R 1245769 CDS LALA0_S02e03796g 34684381 326566..327435 Unknown 1 NW_019212880.1 similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; uncharacterized protein 327435 34684381 LALA0_S02e03796g Lachancea lanzarotensis uncharacterized protein XP_022627207.1 326566 D 1245769 CDS LALA0_S02e03818g 34684382 complement(327473..327997) Unknown 1 NW_019212880.1 similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes; uncharacterized protein 327997 34684382 LALA0_S02e03818g Lachancea lanzarotensis uncharacterized protein XP_022627208.1 327473 R 1245769 CDS LALA0_S02e03862g 34684384 328912..330666 Unknown 1 NW_019212880.1 similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; uncharacterized protein 330666 34684384 LALA0_S02e03862g Lachancea lanzarotensis uncharacterized protein XP_022627209.1 328912 D 1245769 CDS LALA0_S02e03884g 34684385 330811..331833 Unknown 1 NW_019212880.1 weakly similar to uniprot|C5DFS6 Lachancea thermotolerans KLTH0D17556g hypothetical protein; uncharacterized protein 331833 34684385 LALA0_S02e03884g Lachancea lanzarotensis uncharacterized protein XP_022627210.1 330811 D 1245769 CDS LALA0_S02e03906g 34684386 332082..335240 Unknown 1 NW_019212880.1 similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog; uncharacterized protein 335240 34684386 LALA0_S02e03906g Lachancea lanzarotensis uncharacterized protein XP_022627211.1 332082 D 1245769 CDS LALA0_S02e03928g 34684387 335582..337237 Unknown 1 NW_019212880.1 similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 337237 34684387 LALA0_S02e03928g Lachancea lanzarotensis uncharacterized protein XP_022627212.1 335582 D 1245769 CDS LALA0_S02e03950g 34684388 337560..338201 Unknown 1 NW_019212880.1 highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine; xanthine phosphoribosyltransferase 338201 34684388 LALA0_S02e03950g Lachancea lanzarotensis xanthine phosphoribosyltransferase XP_022627213.1 337560 D 1245769 CDS LALA0_S02e03972g 34684389 complement(338283..340211) Unknown 1 NW_019212880.1 weakly similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; uncharacterized protein 340211 34684389 LALA0_S02e03972g Lachancea lanzarotensis uncharacterized protein XP_022627214.1 338283 R 1245769 CDS LALA0_S02e03994g 34684390 340931..343219 Unknown 1 NW_019212880.1 similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles; uncharacterized protein 343219 34684390 LALA0_S02e03994g Lachancea lanzarotensis uncharacterized protein XP_022627215.1 340931 D 1245769 CDS LALA0_S02e04016g 34684391 complement(343230..343913) Unknown 1 NW_019212880.1 similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner; uncharacterized protein 343913 34684391 LALA0_S02e04016g Lachancea lanzarotensis uncharacterized protein XP_022627216.1 343230 R 1245769 CDS LALA0_S02e04038g 34684392 344148..344411 Unknown 1 NW_019212880.1 highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome; protein transporter TIM8 344411 34684392 LALA0_S02e04038g Lachancea lanzarotensis protein transporter TIM8 XP_022627217.1 344148 D 1245769 CDS LALA0_S02e04060g 34684393 complement(344642..345907) Unknown 1 NW_019212880.1 similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C TTI2 Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm; uncharacterized protein 345907 34684393 LALA0_S02e04060g Lachancea lanzarotensis uncharacterized protein XP_022627218.1 344642 R 1245769 CDS LALA0_S02e04082g 34684394 346944..349124 Unknown 1 NW_019212880.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 349124 34684394 LALA0_S02e04082g Lachancea lanzarotensis uncharacterized protein XP_022627219.1 346944 D 1245769 CDS LALA0_S02e04104g 34684395 complement(349162..350103) Unknown 1 NW_019212880.1 similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C AIM18 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 350103 34684395 LALA0_S02e04104g Lachancea lanzarotensis uncharacterized protein XP_022627220.1 349162 R 1245769 CDS LALA0_S02e04126g 34684396 complement(350462..354877) Unknown 1 NW_019212880.1 similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C MET5 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine; sulfite reductase (NADPH) subunit beta 354877 34684396 LALA0_S02e04126g Lachancea lanzarotensis sulfite reductase (NADPH) subunit beta XP_022627221.1 350462 R 1245769 CDS LALA0_S02e04148g 34684397 357681..360188 Unknown 1 NW_019212880.1 putative transposase of the Rover hAT-like DNA transposon 360188 34684397 LALA0_S02e04148g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022627222.1 357681 D 1245769 CDS LALA0_S02e04170g 34684398 complement(360456..360668) Unknown 1 NW_019212880.1 highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III; DNA-directed RNA polymerase core subunit RPC10 360668 34684398 LALA0_S02e04170g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPC10 XP_022627223.1 360456 R 1245769 CDS LALA0_S02e04192g 34684399 complement(360959..361969) Unknown 1 NW_019212880.1 weakly similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner; uncharacterized protein 361969 34684399 LALA0_S02e04192g Lachancea lanzarotensis uncharacterized protein XP_022627224.1 360959 R 1245769 CDS LALA0_S02e04214g 34684400 362263..363378 Unknown 1 NW_019212880.1 weakly similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Putative protein of unknown function; YNL165W is not an essential gene; uncharacterized protein 363378 34684400 LALA0_S02e04214g Lachancea lanzarotensis uncharacterized protein XP_022627225.1 362263 D 1245769 CDS LALA0_S02e04236g 34684401 complement(363548..364447) Unknown 1 NW_019212880.1 similar to uniprot|P38844 Saccharomyces cerevisiae YHR143W DSE2 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP; uncharacterized protein 364447 34684401 LALA0_S02e04236g Lachancea lanzarotensis uncharacterized protein XP_022627226.1 363548 R 1245769 CDS LALA0_S02e04258g 34684402 complement(365170..366090) Unknown 1 NW_019212880.1 weakly similar to uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p; uncharacterized protein 366090 34684402 LALA0_S02e04258g Lachancea lanzarotensis uncharacterized protein XP_022627227.1 365170 R 1245769 CDS LALA0_S02e04280g 34684403 complement(366282..369593) Unknown 1 NW_019212880.1 similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C RIA1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p); GTPase RIA1 369593 34684403 LALA0_S02e04280g Lachancea lanzarotensis GTPase RIA1 XP_022627228.1 366282 R 1245769 CDS LALA0_S02e04302g 34684404 369717..369935 Unknown 1 NW_019212880.1 similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A Putative protein of unknown function; identified by homology; uncharacterized protein 369935 34684404 LALA0_S02e04302g Lachancea lanzarotensis uncharacterized protein XP_022627229.1 369717 D 1245769 CDS LALA0_S02e04324g 34684405 complement(370087..371046) Unknown 1 NW_019212880.1 similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER; uncharacterized protein 371046 34684405 LALA0_S02e04324g Lachancea lanzarotensis uncharacterized protein XP_022627230.1 370087 R 1245769 CDS LALA0_S02e04346g 34684406 join(372100..372103,372523..372839) Unknown 1 NW_019212880.1 highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C (ohnolog of YNL162W) RPL42B Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; 60S ribosomal protein eL42 372839 34684406 LALA0_S02e04346g Lachancea lanzarotensis 60S ribosomal protein eL42 XP_022627231.1 372100 D 1245769 CDS LALA0_S02e04368g 34684407 373265..375511 Unknown 1 NW_019212880.1 similar to uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Serine/threonine protein kinase that regulates cell morphogenesis pathways, including cell wall biosynthesis, mating projection morphology, bipolar bud site selection; regulates SRL1 mRNA localization via phosphorylation of substrate Ssd1p; serine/threonine protein kinase CBK1 375511 34684407 LALA0_S02e04368g Lachancea lanzarotensis serine/threonine protein kinase CBK1 XP_022627232.1 373265 D 1245769 CDS LALA0_S02e04390g 34684408 complement(376427..377110) Unknown 1 NW_019212880.1 similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Putative integral membrane protein of unknown function; uncharacterized protein 377110 34684408 LALA0_S02e04390g Lachancea lanzarotensis uncharacterized protein XP_022627233.1 376427 R 1245769 CDS LALA0_S02e04412g 34684409 378213..379355 Unknown 1 NW_019212880.1 similar to uniprot|P13130 Saccharomyces cerevisiae YHR139C (ohnolog of YNL160W) SPS100 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; uncharacterized protein 379355 34684409 LALA0_S02e04412g Lachancea lanzarotensis uncharacterized protein XP_022627234.1 378213 D 1245769 CDS LALA0_S02e04434g 34684410 complement(380504..381589) Unknown 1 NW_019212880.1 similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C Putative dihydrokaempferol 4-reductase; uncharacterized protein 381589 34684410 LALA0_S02e04434g Lachancea lanzarotensis uncharacterized protein XP_022627235.1 380504 R 1245769 CDS LALA0_S02e04456g 34684411 383655..385139 Unknown 1 NW_019212880.1 highly similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; ammonium permease MEP2 385139 34684411 LALA0_S02e04456g Lachancea lanzarotensis ammonium permease MEP2 XP_022627236.1 383655 D 1245769 CDS LALA0_S02e04478g 34684412 join(385412..385472,385548..385828) Unknown 1 NW_019212880.1 similar to uniprot|P38841 Saccharomyces cerevisiae YHR138C Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles; uncharacterized protein 385828 34684412 LALA0_S02e04478g Lachancea lanzarotensis uncharacterized protein XP_022627237.1 385412 D 1245769 CDS LALA0_S02e04500g 34684413 complement(join(386043..386423,386488..386496)) Unknown 1 NW_019212880.1 highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; tubulin-binding prefolding complex subunit GIM3 386496 34684413 LALA0_S02e04500g Lachancea lanzarotensis tubulin-binding prefolding complex subunit GIM3 XP_022627238.1 386043 R 1245769 CDS LALA0_S02e04522g 34684414 complement(386688..388283) Unknown 1 NW_019212880.1 similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism; aromatic-amino-acid:2-oxoglutarate transaminase 388283 34684414 LALA0_S02e04522g Lachancea lanzarotensis aromatic-amino-acid:2-oxoglutarate transaminase XP_022627239.1 386688 R 1245769 CDS LALA0_S02e04544g 34684415 complement(388500..389000) Unknown 1 NW_019212880.1 hypothetical protein; uncharacterized protein 389000 34684415 LALA0_S02e04544g Lachancea lanzarotensis uncharacterized protein XP_022627240.1 388500 R 1245769 CDS LALA0_S02e04566g 34684416 complement(390925..391935) Unknown 1 NW_019212880.1 similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; malate dehydrogenase MDH3 391935 34684416 LALA0_S02e04566g Lachancea lanzarotensis malate dehydrogenase MDH3 XP_022627241.1 390925 R 1245769 CDS LALA0_S02e04588g 34684417 complement(392524..393126) Unknown 1 NW_019212880.1 similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog; Arf family GTPase CIN4 393126 34684417 LALA0_S02e04588g Lachancea lanzarotensis Arf family GTPase CIN4 XP_022627242.1 392524 R 1245769 CDS LALA0_S02e04610g 34684418 393285..395183 Unknown 1 NW_019212880.1 weakly similar to uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; DNA cross-link repair protein PSO2 395183 34684418 LALA0_S02e04610g Lachancea lanzarotensis DNA cross-link repair protein PSO2 XP_022627243.1 393285 D 1245769 CDS LALA0_S02e04632g 34684419 complement(395240..396595) Unknown 1 NW_019212880.1 weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; uncharacterized protein 396595 34684419 LALA0_S02e04632g Lachancea lanzarotensis uncharacterized protein XP_022627244.1 395240 R 1245769 CDS LALA0_S02e04654g 34684420 398833..399993 Unknown 1 NW_019212880.1 similar to uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START; glucose-induced degradation complex subunit GID8 399993 34684420 LALA0_S02e04654g Lachancea lanzarotensis glucose-induced degradation complex subunit GID8 XP_022627245.1 398833 D 1245769 CDS LALA0_S02e04676g 34684421 complement(400049..400789) Unknown 1 NW_019212880.1 similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes; uncharacterized protein 400789 34684421 LALA0_S02e04676g Lachancea lanzarotensis uncharacterized protein XP_022627246.1 400049 R 1245769 CDS LALA0_S02e04698g 34684422 complement(401192..401665) Unknown 1 NW_019212880.1 hypothetical protein; uncharacterized protein 401665 34684422 LALA0_S02e04698g Lachancea lanzarotensis uncharacterized protein XP_022627247.1 401192 R 1245769 CDS LALA0_S02e04720g 34684423 401713..402300 Unknown 1 NW_019212880.1 hypothetical protein; uncharacterized protein 402300 34684423 LALA0_S02e04720g Lachancea lanzarotensis uncharacterized protein XP_022627248.1 401713 D 1245769 CDS LALA0_S02e04742g 34684424 complement(402429..403784) Unknown 1 NW_019212880.1 weakly similar to Lachancea thermotolerans KLTH0E09042g hypothetical protein; uncharacterized protein 403784 34684424 LALA0_S02e04742g Lachancea lanzarotensis uncharacterized protein XP_022627249.1 402429 R 1245769 CDS LALA0_S02e04764g 34684425 404095..404685 Unknown 1 NW_019212880.1 similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein); uncharacterized protein 404685 34684425 LALA0_S02e04764g Lachancea lanzarotensis uncharacterized protein XP_022627250.1 404095 D 1245769 CDS LALA0_S02e04786g 34684426 404994..406598 Unknown 1 NW_019212880.1 highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p; ribosome biosynthesis protein RRB1 406598 34684426 LALA0_S02e04786g Lachancea lanzarotensis ribosome biosynthesis protein RRB1 XP_022627251.1 404994 D 1245769 CDS LALA0_S02e04808g 34684427 406834..409785 Unknown 1 NW_019212880.1 similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes; uncharacterized protein 409785 34684427 LALA0_S02e04808g Lachancea lanzarotensis uncharacterized protein XP_022627252.1 406834 D 1245769 CDS LALA0_S02e04830g 34684428 410074..410322 Unknown 1 NW_019212880.1 highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; cytochrome c oxidase subunit VIb 410322 34684428 LALA0_S02e04830g Lachancea lanzarotensis cytochrome c oxidase subunit VIb XP_022627253.1 410074 D 1245769 CDS LALA0_S02e04852g 34684429 complement(join(410706..411466,411532..411730)) Unknown 1 NW_019212880.1 similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Putative protein of unknown function; YMR130W is not an essential gene; uncharacterized protein 411730 34684429 LALA0_S02e04852g Lachancea lanzarotensis uncharacterized protein XP_022627254.1 410706 R 1245769 CDS LALA0_S02e04874g 34684430 complement(411926..415801) Unknown 1 NW_019212880.1 similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; uncharacterized protein 415801 34684430 LALA0_S02e04874g Lachancea lanzarotensis uncharacterized protein XP_022627255.1 411926 R 1245769 CDS LALA0_S02e04896g 34684431 416935..418341 Unknown 1 NW_019212880.1 highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; uncharacterized protein 418341 34684431 LALA0_S02e04896g Lachancea lanzarotensis uncharacterized protein XP_022627256.1 416935 D 1245769 CDS LALA0_S02e04918g 34684432 complement(join(418422..419922,420020..420066)) Unknown 1 NW_019212880.1 similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance; uncharacterized protein 420066 34684432 LALA0_S02e04918g Lachancea lanzarotensis uncharacterized protein XP_022627257.1 418422 R 1245769 CDS LALA0_S02e04940g 34684433 complement(420393..424121) Unknown 1 NW_019212880.1 similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis; ATP-dependent RNA helicase ECM16 424121 34684433 LALA0_S02e04940g Lachancea lanzarotensis ATP-dependent RNA helicase ECM16 XP_022627258.1 420393 R 1245769 CDS LALA0_S02e04962g 34684434 424437..425408 Unknown 1 NW_019212880.1 similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; histone acetyltransferase 425408 34684434 LALA0_S02e04962g Lachancea lanzarotensis histone acetyltransferase XP_022627259.1 424437 D 1245769 CDS LALA0_S02e04984g 34684435 complement(425457..428882) Unknown 1 NW_019212880.1 similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; DNA helicase RAD5 428882 34684435 LALA0_S02e04984g Lachancea lanzarotensis DNA helicase RAD5 XP_022627260.1 425457 R 1245769 CDS LALA0_S02e05006g 34684436 429334..430296 Unknown 1 NW_019212880.1 similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); uncharacterized protein 430296 34684436 LALA0_S02e05006g Lachancea lanzarotensis uncharacterized protein XP_022627261.1 429334 D 1245769 CDS LALA0_S02e05028g 34684437 complement(join(430369..432908,433192..433216)) Unknown 1 NW_019212880.1 similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; uncharacterized protein 433216 34684437 LALA0_S02e05028g Lachancea lanzarotensis uncharacterized protein XP_022627262.1 430369 R 1245769 CDS LALA0_S02e05050g 34684438 complement(434245..437181) Unknown 1 NW_019212880.1 weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W (ohnolog of YLR031W) Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization; uncharacterized protein 437181 34684438 LALA0_S02e05050g Lachancea lanzarotensis uncharacterized protein XP_022627263.1 434245 R 1245769 CDS LALA0_S02e05072g 34684439 complement(438185..438553) Unknown 1 NW_019212880.1 similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); uncharacterized protein 438553 34684439 LALA0_S02e05072g Lachancea lanzarotensis uncharacterized protein XP_022627264.1 438185 R 1245769 CDS LALA0_S02e05094g 34684440 complement(439015..439341) Unknown 1 NW_019212880.1 similar to uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum; uncharacterized protein 439341 34684440 LALA0_S02e05094g Lachancea lanzarotensis uncharacterized protein XP_022627265.1 439015 R 1245769 CDS LALA0_S02e05116g 34684441 complement(440363..440779) Unknown 1 NW_019212880.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 440779 34684441 LALA0_S02e05116g Lachancea lanzarotensis uncharacterized protein XP_022627266.1 440363 R 1245769 CDS LALA0_S02e05138g 34684442 442367..442981 Unknown 1 NW_019212880.1 highly similar to uniprot|P54780 Saccharomyces cerevisiae YMR121C (ohnolog of YLR029C) RPL15B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA; 60S ribosomal protein eL15 442981 34684442 LALA0_S02e05138g Lachancea lanzarotensis 60S ribosomal protein eL15 XP_022627267.1 442367 D 1245769 CDS LALA0_S02e05160g 34684443 443572..445350 Unknown 1 NW_019212880.1 highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C (ohnolog of YLR028C) ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 445350 34684443 LALA0_S02e05160g Lachancea lanzarotensis bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 XP_022627268.1 443572 D 1245769 CDS LALA0_S02e05182g 34684444 complement(446315..448231) Unknown 1 NW_019212880.1 similar to uniprot|P53983 Saccharomyces cerevisiae YNL008C (ohnolog of YMR119W) ASI3 Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; uncharacterized protein 448231 34684444 LALA0_S02e05182g Lachancea lanzarotensis uncharacterized protein XP_022627269.1 446315 R 1245769 CDS LALA0_S02e05226g 34684446 join(448934..449086,449166..449819) Unknown 1 NW_019212880.1 similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W REC102 Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination; uncharacterized protein 449819 34684446 LALA0_S02e05226g Lachancea lanzarotensis uncharacterized protein XP_022627270.1 448934 D 1245769 CDS LALA0_S02e05248g 34684447 complement(449776..450372) Unknown 1 NW_019212880.1 similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Putative protein of unknown function; uncharacterized protein 450372 34684447 LALA0_S02e05248g Lachancea lanzarotensis uncharacterized protein XP_022627271.1 449776 R 1245769 CDS LALA0_S02e05270g 34684448 450528..451451 Unknown 1 NW_019212880.1 similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; uncharacterized protein 451451 34684448 LALA0_S02e05270g Lachancea lanzarotensis uncharacterized protein XP_022627272.1 450528 D 1245769 CDS LALA0_S02e05292g 34684449 complement(451564..455421) Unknown 1 NW_019212880.1 weakly similar to uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; uncharacterized protein 455421 34684449 LALA0_S02e05292g Lachancea lanzarotensis uncharacterized protein XP_022627273.1 451564 R 1245769 CDS LALA0_S02e05314g 34684450 complement(456570..458237) Unknown 1 NW_019212880.1 similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; uncharacterized protein 458237 34684450 LALA0_S02e05314g Lachancea lanzarotensis uncharacterized protein XP_022627274.1 456570 R 1245769 CDS LALA0_S02e05336g 34684451 complement(459007..460176) Unknown 1 NW_019212880.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Putative cysteine synthase, localized to the mitochondrial outer membrane; uncharacterized protein 460176 34684451 LALA0_S02e05336g Lachancea lanzarotensis uncharacterized protein XP_022627275.1 459007 R 1245769 CDS LALA0_S02e05358g 34684452 complement(461360..463561) Unknown 1 NW_019212880.1 putative transposase of the Rover hAT-like DNA transposon 463561 34684452 LALA0_S02e05358g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022627276.1 461360 R 1245769 CDS LALA0_S02e05380g 34684453 join(466647..467153,467156..467281,467281..467664,467666..468124) Unknown 1 NW_019212880.1 hypothetical protein; 468124 34684453 LALA0_S02e05380g Lachancea lanzarotensis 466647 D 1245769 CDS LALA0_S02e05402g 34684454 469706..472297 Unknown 1 NW_019212880.1 similar to uniprot|C5DGC0 Lachancea thermotolerans KLTH0D04070g hypothetical protein; uncharacterized protein 472297 34684454 LALA0_S02e05402g Lachancea lanzarotensis uncharacterized protein XP_022627277.1 469706 D 1245769 CDS LALA0_S02e05424g 34684455 complement(472654..473982) Unknown 1 NW_019212880.1 similar to uniprot|P53204 Saccharomyces cerevisiae YGR010W (ohnolog of YLR328W) NMA2 Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+); nicotinamide-nucleotide adenylyltransferase NMA2 473982 34684455 LALA0_S02e05424g Lachancea lanzarotensis nicotinamide-nucleotide adenylyltransferase NMA2 XP_022627278.1 472654 R 1245769 CDS LALA0_S02e05446g 34684456 476624..478852 Unknown 1 NW_019212880.1 weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains; uncharacterized protein 478852 34684456 LALA0_S02e05446g Lachancea lanzarotensis uncharacterized protein XP_022627279.1 476624 D 1245769 CDS LALA0_S02e05468g 34684457 complement(478932..480197) Unknown 1 NW_019212880.1 similar to uniprot|P38347 Saccharomyces cerevisiae YBR271W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis; S-adenosylmethionine-dependent methyltransferase 480197 34684457 LALA0_S02e05468g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022627280.1 478932 R 1245769 CDS LALA0_S02e05490g 34684458 480694..482517 Unknown 1 NW_019212880.1 similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C IKS1 Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p; protein kinase IKS1 482517 34684458 LALA0_S02e05490g Lachancea lanzarotensis protein kinase IKS1 XP_022627281.1 480694 D 1245769 CDS LALA0_S02e05512g 34684459 482657..484300 Unknown 1 NW_019212880.1 similar to uniprot|P47041 Saccharomyces cerevisiae YJL058C (ohnolog of YBR270C) BIT61 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; uncharacterized protein 484300 34684459 LALA0_S02e05512g Lachancea lanzarotensis uncharacterized protein XP_022627282.1 482657 D 1245769 CDS LALA0_S02e05534g 34684460 complement(484323..485528) Unknown 1 NW_019212880.1 similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis); amino acid transporter YHC3 485528 34684460 LALA0_S02e05534g Lachancea lanzarotensis amino acid transporter YHC3 XP_022627283.1 484323 R 1245769 CDS LALA0_S02e05556g 34684461 complement(485755..487077) Unknown 1 NW_019212880.1 highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate; kynurenine--oxoglutarate transaminase 487077 34684461 LALA0_S02e05556g Lachancea lanzarotensis kynurenine--oxoglutarate transaminase XP_022627284.1 485755 R 1245769 CDS LALA0_S02e05578g 34684462 487843..491133 Unknown 1 NW_019212880.1 similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats; possibly involved in transcription elongation as a component of the PAF complex; uncharacterized protein 491133 34684462 LALA0_S02e05578g Lachancea lanzarotensis uncharacterized protein XP_022627285.1 487843 D 1245769 CDS LALA0_S02e05600g 34684463 complement(491260..491826) Unknown 1 NW_019212880.1 similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; DNA replication protein PSF3 491826 34684463 LALA0_S02e05600g Lachancea lanzarotensis DNA replication protein PSF3 XP_022627286.1 491260 R 1245769 CDS LALA0_S02e05622g 34684464 493271..493969 Unknown 1 NW_019212880.1 similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p; uncharacterized protein 493969 34684464 LALA0_S02e05622g Lachancea lanzarotensis uncharacterized protein XP_022627287.1 493271 D 1245769 CDS LALA0_S02e05644g 34684465 494226..496067 Unknown 1 NW_019212880.1 similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; uncharacterized protein 496067 34684465 LALA0_S02e05644g Lachancea lanzarotensis uncharacterized protein XP_022627288.1 494226 D 1245769 CDS LALA0_S02e05666g 34684466 complement(496158..496772) Unknown 1 NW_019212880.1 similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; uncharacterized protein 496772 34684466 LALA0_S02e05666g Lachancea lanzarotensis uncharacterized protein XP_022627289.1 496158 R 1245769 CDS LALA0_S02e05688g 34684467 498151..500202 Unknown 1 NW_019212880.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; uncharacterized protein 500202 34684467 LALA0_S02e05688g Lachancea lanzarotensis uncharacterized protein XP_022627290.1 498151 D 1245769 CDS LALA0_S02e05710g 34684468 501396..502769 Unknown 1 NW_019212880.1 weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1; uncharacterized protein 502769 34684468 LALA0_S02e05710g Lachancea lanzarotensis uncharacterized protein XP_022627291.1 501396 D 1245769 CDS LALA0_S02e05732g 34684469 504648..506249 Unknown 1 NW_019212880.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; uncharacterized protein 506249 34684469 LALA0_S02e05732g Lachancea lanzarotensis uncharacterized protein XP_022627292.1 504648 D 1245769 CDS LALA0_S02e05754g 34684470 507271..509808 Unknown 1 NW_019212880.1 similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 509808 34684470 LALA0_S02e05754g Lachancea lanzarotensis uncharacterized protein XP_022627293.1 507271 D 1245769 CDS LALA0_S02e05776g 34684471 complement(511094..512293) Unknown 1 NW_019212880.1 similar to uniprot|P43623 Saccharomyces cerevisiae YFR055W IRC7 Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner; uncharacterized protein 512293 34684471 LALA0_S02e05776g Lachancea lanzarotensis uncharacterized protein XP_022627294.1 511094 R 1245769 CDS LALA0_S02e05798g 34684472 complement(513620..514537) Unknown 1 NW_019212880.1 highly similar to uniprot|G8ZP09 Torulaspora delbrueckii TDEL_0B02240 hypothetical protein; uncharacterized protein 514537 34684472 LALA0_S02e05798g Lachancea lanzarotensis uncharacterized protein XP_022627295.1 513620 R 1245769 CDS LALA0_S02e05820g 34684473 516344..516646 Unknown 1 NW_019212880.1 some similarities with uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; uncharacterized protein 516646 34684473 LALA0_S02e05820g Lachancea lanzarotensis uncharacterized protein XP_022627296.1 516344 D 1245769 CDS LALA0_S02e05842g 34684474 complement(517464..519497) Unknown 1 NW_019212880.1 weakly similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; uncharacterized protein 519497 34684474 LALA0_S02e05842g Lachancea lanzarotensis uncharacterized protein XP_022627297.1 517464 R 1245769 CDS LALA0_S02e05864g 34684475 complement(join(520298..520435,520437..520616,520616..520765,520764..521072,521075..521320)) Unknown 1 NW_019212880.1 some similarities with uniprot|P28273 Saccharomyces cerevisiae YKL215C OXP1 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; 521320 34684475 LALA0_S02e05864g Lachancea lanzarotensis 520298 R 1245769 CDS LALA0_S02e05886g 34684476 complement(522657..523793) Unknown 1 NW_019212880.1 weakly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate; uncharacterized protein 523793 34684476 LALA0_S02e05886g Lachancea lanzarotensis uncharacterized protein XP_022627298.1 522657 R 1245769 CDS LALA0_S02e05908g 34684477 complement(524721..526430) Unknown 1 NW_019212880.1 highly similar to uniprot|C5DC09 Lachancea thermotolerans KLTH0A06908g hypothetical protein; uncharacterized protein 526430 34684477 LALA0_S02e05908g Lachancea lanzarotensis uncharacterized protein XP_022627299.1 524721 R 1245769 CDS LALA0_S02e05930g 34684478 529258..530796 Unknown 1 NW_019212880.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 530796 34684478 LALA0_S02e05930g Lachancea lanzarotensis uncharacterized protein XP_022627300.1 529258 D 1245769 CDS LALA0_S02e05952g 34684479 complement(531105..532325) Unknown 1 NW_019212880.1 some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; uncharacterized protein 532325 34684479 LALA0_S02e05952g Lachancea lanzarotensis uncharacterized protein XP_022627301.1 531105 R 1245769 CDS LALA0_S02e05974g 34684480 533920..535158 Unknown 1 NW_019212880.1 similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; uncharacterized protein 535158 34684480 LALA0_S02e05974g Lachancea lanzarotensis uncharacterized protein XP_022627302.1 533920 D 1245769 CDS LALA0_S02e05996g 34684481 535473..536198 Unknown 1 NW_019212880.1 similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C AIM2 Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor; protein AIM2 536198 34684481 LALA0_S02e05996g Lachancea lanzarotensis protein AIM2 XP_022627303.1 535473 D 1245769 CDS LALA0_S02e06018g 34684482 536675..538549 Unknown 1 NW_019212880.1 weakly similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer; uncharacterized protein 538549 34684482 LALA0_S02e06018g Lachancea lanzarotensis uncharacterized protein XP_022627304.1 536675 D 1245769 CDS LALA0_S02e06040g 34684483 539400..540314 Unknown 1 NW_019212880.1 similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p; uncharacterized protein 540314 34684483 LALA0_S02e06040g Lachancea lanzarotensis uncharacterized protein XP_022627305.1 539400 D 1245769 CDS LALA0_S02e06062g 34684484 complement(541326..543275) Unknown 1 NW_019212880.1 similar to uniprot|P43549 Saccharomyces cerevisiae YFL054C Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol; uncharacterized protein 543275 34684484 LALA0_S02e06062g Lachancea lanzarotensis uncharacterized protein XP_022627306.1 541326 R 1245769 CDS LALA0_S02e06084g 34684485 545770..546723 Unknown 1 NW_019212880.1 similar to uniprot|P53743 Saccharomyces cerevisiae YNR054C ESF2 Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome; RNA-binding ATPase activator ESF2 546723 34684485 LALA0_S02e06084g Lachancea lanzarotensis RNA-binding ATPase activator ESF2 XP_022627307.1 545770 D 1245769 CDS LALA0_S02e06106g 34684486 join(547092..547901,548373..549098) Unknown 1 NW_019212880.1 highly similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; uncharacterized protein 549098 34684486 LALA0_S02e06106g Lachancea lanzarotensis uncharacterized protein XP_022627308.1 547092 D 1245769 CDS LALA0_S02e06128g 34684487 550677..552044 Unknown 1 NW_019212880.1 similar to uniprot|P39008 Saccharomyces cerevisiae YNR052C POP2 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; CCR4-NOT core DEDD family RNase subunit POP2 552044 34684487 LALA0_S02e06128g Lachancea lanzarotensis CCR4-NOT core DEDD family RNase subunit POP2 XP_022627309.1 550677 D 1245769 CDS LALA0_S02e06150g 34684488 552853..554283 Unknown 1 NW_019212880.1 similar to uniprot|P53741 Saccharomyces cerevisiae YNR051C BRE5 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; uncharacterized protein 554283 34684488 LALA0_S02e06150g Lachancea lanzarotensis uncharacterized protein XP_022627310.1 552853 D 1245769 CDS LALA0_S02e06172g 34684489 join(554722..554767,554849..555807) Unknown 1 NW_019212880.1 similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C OCA4 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 555807 34684489 LALA0_S02e06172g Lachancea lanzarotensis uncharacterized protein XP_022627311.1 554722 D 1245769 CDS LALA0_S02e06194g 34684490 556469..557809 Unknown 1 NW_019212880.1 highly similar to uniprot|P38999 Saccharomyces cerevisiae YNR050C LYS9 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112; saccharopine dehydrogenase (NADP+, L-glutamate-forming) 557809 34684490 LALA0_S02e06194g Lachancea lanzarotensis saccharopine dehydrogenase (NADP+, L-glutamate-forming) XP_022627312.1 556469 D 1245769 CDS LALA0_S02e06216g 34684491 558052..558576 Unknown 1 NW_019212880.1 weakly similar to uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of thesecretory vesicle docking complex, acts at a late step insecretion; shows genetic and physical interactions withSec1p; required for prospore membrane formation duringsporulation; uncharacterized protein 558576 34684491 LALA0_S02e06216g Lachancea lanzarotensis uncharacterized protein XP_022627313.1 558052 D 1245769 CDS LALA0_S02e06238g 34684492 complement(559645..560295) Unknown 1 NW_019212880.1 highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; E2 ubiquitin-conjugating protein UBC1 560295 34684492 LALA0_S02e06238g Lachancea lanzarotensis E2 ubiquitin-conjugating protein UBC1 XP_022627314.1 559645 R 1245769 CDS LALA0_S02e06260g 34684493 complement(560455..561639) Unknown 1 NW_019212880.1 similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W (ohnolog of YNR048W) CDC50 Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p; uncharacterized protein 561639 34684493 LALA0_S02e06260g Lachancea lanzarotensis uncharacterized protein XP_022627315.1 560455 R 1245769 CDS LALA0_S02e06282g 34684494 complement(<561976..568632) Unknown 1 NW_019212880.1 similar to uniprot|P25655 Saccharomyces cerevisiae YCR093W CDC39 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; CCR4-NOT core subunit CDC39 568632 34684494 LALA0_S02e06282g Lachancea lanzarotensis CCR4-NOT core subunit CDC39 XP_022627316.1 561976 R 1245769 CDS LALA0_S02e06304g 34684495 569704..572790 Unknown 1 NW_019212880.1 similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability; mismatch repair protein MSH3 572790 34684495 LALA0_S02e06304g Lachancea lanzarotensis mismatch repair protein MSH3 XP_022627317.1 569704 D 1245769 CDS LALA0_S02e06326g 34684496 complement(572851..575412) Unknown 1 NW_019212880.1 similar to uniprot|P25341 Saccharomyces cerevisiae YCR091W (ohnolog of YNR047W) KIN82 Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p; uncharacterized protein 575412 34684496 LALA0_S02e06326g Lachancea lanzarotensis uncharacterized protein XP_022627318.1 572851 R 1245769 CDS LALA0_S02e06348g 34684497 complement(576431..576832) Unknown 1 NW_019212880.1 highly similar to uniprot|P53738 Saccharomyces cerevisiae YNR046W TRM112 Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; RNA methylation protein TRM112 576832 34684497 LALA0_S02e06348g Lachancea lanzarotensis RNA methylation protein TRM112 XP_022627319.1 576431 R 1245769 CDS LALA0_S02e06370g 34684498 complement(577442..578731) Unknown 1 NW_019212880.1 weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane; uncharacterized protein 578731 34684498 LALA0_S02e06370g Lachancea lanzarotensis uncharacterized protein XP_022627320.1 577442 R 1245769 CDS LALA0_S02e06392g 34684499 578946..579503 Unknown 1 NW_019212880.1 similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene; uncharacterized protein 579503 34684499 LALA0_S02e06392g Lachancea lanzarotensis uncharacterized protein XP_022627321.1 578946 D 1245769 CDS LALA0_S02e06414g 34684500 complement(579676..583371) Unknown 1 NW_019212880.1 weakly similar to uniprot|P25653 Saccharomyces cerevisiae YCR089W (ohnolog of YNR044W) FIG2 Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; uncharacterized protein 583371 34684500 LALA0_S02e06414g Lachancea lanzarotensis uncharacterized protein XP_022627322.1 579676 R 1245769 CDS LALA0_S02e06436g 34684501 complement(583881..585686) Unknown 1 NW_019212880.1 similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; uncharacterized protein 585686 34684501 LALA0_S02e06436g Lachancea lanzarotensis uncharacterized protein XP_022627323.1 583881 R 1245769 CDS LALA0_S02e06458g 34684502 586448..586957 Unknown 1 NW_019212880.1 similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene; uncharacterized protein 586957 34684502 LALA0_S02e06458g Lachancea lanzarotensis uncharacterized protein XP_022627324.1 586448 D 1245769 CDS LALA0_S02e06480g 34684503 complement(587229..587777) Unknown 1 NW_019212880.1 similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation; uncharacterized protein 587777 34684503 LALA0_S02e06480g Lachancea lanzarotensis uncharacterized protein XP_022627325.1 587229 R 1245769 CDS LALA0_S02e06502g 34684504 589231..591450 Unknown 1 NW_019212880.1 similar to uniprot|P18323 Saccharomyces cerevisiae YCR084C TUP1 General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes; chromatin-silencing transcriptional regulator TUP1 591450 34684504 LALA0_S02e06502g Lachancea lanzarotensis chromatin-silencing transcriptional regulator TUP1 XP_022627326.1 589231 D 1245769 CDS LALA0_S02e06524g 34684505 complement(591655..593814) Unknown 1 NW_019212880.1 weakly similar to uniprot|P35995 Saccharomyces cerevisiae YKL222C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine; uncharacterized protein 593814 34684505 LALA0_S02e06524g Lachancea lanzarotensis uncharacterized protein XP_022627327.1 591655 R 1245769 CDS LALA0_S02e06546g 34684506 complement(join(594177..595325,595461..595505)) Unknown 1 NW_019212880.1 highly similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer; diphosphomevalonate decarboxylase MVD1 595505 34684506 LALA0_S02e06546g Lachancea lanzarotensis diphosphomevalonate decarboxylase MVD1 XP_022627328.1 594177 R 1245769 CDS LALA0_S02e06568g 34684507 596554..597006 Unknown 1 NW_019212880.1 similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex; uncharacterized protein 597006 34684507 LALA0_S02e06568g Lachancea lanzarotensis uncharacterized protein XP_022627329.1 596554 D 1245769 CDS LALA0_S02e06590g 34684508 598116..598502 Unknown 1 NW_019212880.1 similar to uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p; uncharacterized protein 598502 34684508 LALA0_S02e06590g Lachancea lanzarotensis uncharacterized protein XP_022627330.1 598116 D 1245769 CDS LALA0_S02e06612g 34684509 598690..599523 Unknown 1 NW_019212880.1 weakly similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 599523 34684509 LALA0_S02e06612g Lachancea lanzarotensis uncharacterized protein XP_022627331.1 598690 D 1245769 CDS LALA0_S02e06634g 34684510 complement(599584..600690) Unknown 1 NW_019212880.1 similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; 4-hydroxybenzoate octaprenyltransferase 600690 34684510 LALA0_S02e06634g Lachancea lanzarotensis 4-hydroxybenzoate octaprenyltransferase XP_022627332.1 599584 R 1245769 CDS LALA0_S02e06656g 34684511 601849..603564 Unknown 1 NW_019212880.1 similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc; Zn(2+) transporter ZRG17 603564 34684511 LALA0_S02e06656g Lachancea lanzarotensis Zn(2+) transporter ZRG17 XP_022627333.1 601849 D 1245769 CDS LALA0_S02e06678g 34684512 complement(603638..607753) Unknown 1 NW_019212880.1 similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression; uncharacterized protein 607753 34684512 LALA0_S02e06678g Lachancea lanzarotensis uncharacterized protein XP_022627334.1 603638 R 1245769 CDS LALA0_S02e06700g 34684513 complement(609193..611100) Unknown 1 NW_019212880.1 similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; uncharacterized protein 611100 34684513 LALA0_S02e06700g Lachancea lanzarotensis uncharacterized protein XP_022627335.1 609193 R 1245769 CDS LALA0_S02e06722g 34684514 611278..611553 Unknown 1 NW_019212880.1 highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C RSM19 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein; mitochondrial 37S ribosomal protein uS19m 611553 34684514 LALA0_S02e06722g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS19m XP_022627336.1 611278 D 1245769 CDS LALA0_S02e06744g 34684515 complement(611684..613150) Unknown 1 NW_019212880.1 similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W PTC6 Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase; type 2C protein phosphatase PTC6 613150 34684515 LALA0_S02e06744g Lachancea lanzarotensis type 2C protein phosphatase PTC6 XP_022627337.1 611684 R 1245769 CDS LALA0_S02e06766g 34684516 614191..614712 Unknown 1 NW_019212880.1 similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C MRPS12 Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins; mitochondrial 37S ribosomal protein uS12m 614712 34684516 LALA0_S02e06766g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS12m XP_022627338.1 614191 D 1245769 CDS LALA0_S02e06788g 34684517 614956..615930 Unknown 1 NW_019212880.1 similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin; uncharacterized protein 615930 34684517 LALA0_S02e06788g Lachancea lanzarotensis uncharacterized protein XP_022627339.1 614956 D 1245769 CDS LALA0_S02e06810g 34684518 616343..618976 Unknown 1 NW_019212880.1 similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p; uncharacterized protein 618976 34684518 LALA0_S02e06810g Lachancea lanzarotensis uncharacterized protein XP_022627340.1 616343 D 1245769 CDS LALA0_S02e06832g 34684519 619239..620183 Unknown 1 NW_019212880.1 weakly similar to uniprot|P25659 Saccharomyces cerevisiae YCR076C Putative protein of unknown function; YCR076C is not an essential gene; uncharacterized protein 620183 34684519 LALA0_S02e06832g Lachancea lanzarotensis uncharacterized protein XP_022627341.1 619239 D 1245769 CDS LALA0_S02e06854g 34684520 complement(620300..620557) Unknown 1 NW_019212880.1 similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A (ohnolog of YNR034W-A) Putative protein of unknown function; identified by homology to Ashbya gossypii; uncharacterized protein 620557 34684520 LALA0_S02e06854g Lachancea lanzarotensis uncharacterized protein XP_022627342.1 620300 R 1245769 CDS LALA0_S02e06876g 34684521 621726..623465 Unknown 1 NW_019212880.1 similar to uniprot|C5DBY7 Lachancea thermotolerans KLTH0A06402g hypothetical protein; uncharacterized protein 623465 34684521 LALA0_S02e06876g Lachancea lanzarotensis uncharacterized protein XP_022627343.1 621726 D 1245769 CDS LALA0_S02e06898g 34684522 623774..624526 Unknown 1 NW_019212880.1 similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C ERS1 Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; cystinosin-like protein ERS1 624526 34684522 LALA0_S02e06898g Lachancea lanzarotensis cystinosin-like protein ERS1 XP_022627344.1 623774 D 1245769 CDS LALA0_S02e06920g 34684523 complement(624816..625853) Unknown 1 NW_019212880.1 similar to uniprot|P37262 Saccharomyces cerevisiae YCR073W-A (ohnolog of YNR034W) SOL2 Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p; uncharacterized protein 625853 34684523 LALA0_S02e06920g Lachancea lanzarotensis uncharacterized protein XP_022627345.1 624816 R 1245769 CDS LALA0_S02e06942g 34684524 complement(626511..628802) Unknown 1 NW_019212880.1 similar to uniprot|Q6B1Q1 Saccharomyces cerevisiae YNR033W ABZ1 Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; 4-amino-4-deoxychorismate synthase 628802 34684524 LALA0_S02e06942g Lachancea lanzarotensis 4-amino-4-deoxychorismate synthase XP_022627346.1 626511 R 1245769 CDS LALA0_S02e06964g 34684525 630008..630229 Unknown 1 NW_019212880.1 highly similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear; ubiquitin-like protein HUB1 630229 34684525 LALA0_S02e06964g Lachancea lanzarotensis ubiquitin-like protein HUB1 XP_022627347.1 630008 D 1245769 CDS LALA0_S02e06986g 34684526 complement(630641..631693) Unknown 1 NW_019212880.1 highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases; uncharacterized protein 631693 34684526 LALA0_S02e06986g Lachancea lanzarotensis uncharacterized protein XP_022627348.1 630641 R 1245769 CDS LALA0_S02e07008g 34684527 633833..638563 Unknown 1 NW_019212880.1 similar to uniprot|P25390 Saccharomyces cerevisiae YCR073C (ohnolog of YNR031C) SSK22 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; uncharacterized protein 638563 34684527 LALA0_S02e07008g Lachancea lanzarotensis uncharacterized protein XP_022627349.1 633833 D 1245769 CDS LALA0_S02e07030g 34684528 639504..641048 Unknown 1 NW_019212880.1 highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C RSA4 WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; uncharacterized protein 641048 34684528 LALA0_S02e07030g Lachancea lanzarotensis uncharacterized protein XP_022627350.1 639504 D 1245769 CDS LALA0_S02e07052g 34684529 641352..641873 Unknown 1 NW_019212880.1 similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL49 641873 34684529 LALA0_S02e07052g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL49 XP_022627351.1 641352 D 1245769 CDS LALA0_S02e07074g 34684530 complement(641943..643565) Unknown 1 NW_019212880.1 similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ALG12 Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase 643565 34684530 LALA0_S02e07074g Lachancea lanzarotensis dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase XP_022627352.1 641943 R 1245769 CDS LALA0_S02e07096g 34684531 644446..645663 Unknown 1 NW_019212880.1 similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Putative protein of unknown function, deletion confers reduced fitness in saline; GTP-dependent zinc transferase 645663 34684531 LALA0_S02e07096g Lachancea lanzarotensis GTP-dependent zinc transferase XP_022627353.1 644446 D 1245769 CDS LALA0_S02e07118g 34684532 complement(645816..646754) Unknown 1 NW_019212880.1 similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W (ohnolog of YNR028W) CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; uncharacterized protein 646754 34684532 LALA0_S02e07118g Lachancea lanzarotensis uncharacterized protein XP_022627354.1 645816 R 1245769 CDS LALA0_S02e07140g 34684533 648242..650425 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C URC2 Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism; uncharacterized protein 650425 34684533 LALA0_S02e07140g Lachancea lanzarotensis uncharacterized protein XP_022627355.1 648242 D 1245769 CDS LALA0_S02e07162g 34684534 complement(650515..652056) Unknown 1 NW_019212880.1 similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; triglyceride lipase ATG15 652056 34684534 LALA0_S02e07162g Lachancea lanzarotensis triglyceride lipase ATG15 XP_022627356.1 650515 R 1245769 CDS LALA0_S02e07184g 34684535 complement(652231..653145) Unknown 1 NW_019212880.1 similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK); uncharacterized protein 653145 34684535 LALA0_S02e07184g Lachancea lanzarotensis uncharacterized protein XP_022627357.1 652231 R 1245769 CDS LALA0_S02e07206g 34684536 654104..657007 Unknown 1 NW_019212880.1 some similarities with uniprot|P25365 Saccharomyces cerevisiae YCR067C (ohnolog of YNR026C) SED4 Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p; uncharacterized protein 657007 34684536 LALA0_S02e07206g Lachancea lanzarotensis uncharacterized protein XP_022627358.1 654104 D 1245769 CDS LALA0_S02e07228g 34684537 complement(657067..658467) Unknown 1 NW_019212880.1 similar to uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; E3 ubiquitin-protein ligase RAD18 658467 34684537 LALA0_S02e07228g Lachancea lanzarotensis E3 ubiquitin-protein ligase RAD18 XP_022627359.1 657067 R 1245769 CDS LALA0_S02e07250g 34684538 complement(658879..660417) Unknown 1 NW_019212880.1 weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; uncharacterized protein 660417 34684538 LALA0_S02e07250g Lachancea lanzarotensis uncharacterized protein XP_022627360.1 658879 R 1245769 CDS LALA0_S02e07272g 34684539 complement(660904..661374) Unknown 1 NW_019212880.1 highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; U2 snRNP complex subunit BUD31 661374 34684539 LALA0_S02e07272g Lachancea lanzarotensis U2 snRNP complex subunit BUD31 XP_022627361.1 660904 R 1245769 CDS LALA0_S02e07316g 34684541 complement(662385..664340) Unknown 1 NW_019212880.1 similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation; uncharacterized protein 664340 34684541 LALA0_S02e07316g Lachancea lanzarotensis uncharacterized protein XP_022627362.1 662385 R 1245769 CDS LALA0_S02e07338g 34684542 complement(665923..667971) Unknown 1 NW_019212880.1 similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation; uncharacterized protein 667971 34684542 LALA0_S02e07338g Lachancea lanzarotensis uncharacterized protein XP_022627363.1 665923 R 1245769 CDS LALA0_S02e07360g 34684543 670361..671170 Unknown 1 NW_019212880.1 similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene; uncharacterized protein 671170 34684543 LALA0_S02e07360g Lachancea lanzarotensis uncharacterized protein XP_022627364.1 670361 D 1245769 CDS LALA0_S02e07382g 34684544 complement(671283..671819) Unknown 1 NW_019212880.1 similar to uniprot|C5DBV3 Lachancea thermotolerans KLTH0A05610g hypothetical protein; uncharacterized protein 671819 34684544 LALA0_S02e07382g Lachancea lanzarotensis uncharacterized protein XP_022627365.1 671283 R 1245769 CDS LALA0_S02e07404g 34684545 672024..674777 Unknown 1 NW_019212880.1 highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis; snoRNA-binding rRNA-processing protein PWP2 674777 34684545 LALA0_S02e07404g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein PWP2 XP_022627366.1 672024 D 1245769 CDS LALA0_S02e07426g 34684546 675095..676675 Unknown 1 NW_019212880.1 similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; uncharacterized protein 676675 34684546 LALA0_S02e07426g Lachancea lanzarotensis uncharacterized protein XP_022627367.1 675095 D 1245769 CDS LALA0_S02e07448g 34684547 complement(676749..678281) Unknown 1 NW_019212880.1 highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; threonine synthase THR4 678281 34684547 LALA0_S02e07448g Lachancea lanzarotensis threonine synthase THR4 XP_022627368.1 676749 R 1245769 CDS LALA0_S02e07470g 34684548 complement(678621..680042) Unknown 1 NW_019212880.1 similar to uniprot|P25632 Saccharomyces cerevisiae YCR052W (ohnolog of YNR023W) RSC6 Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p; uncharacterized protein 680042 34684548 LALA0_S02e07470g Lachancea lanzarotensis uncharacterized protein XP_022627369.1 678621 R 1245769 CDS LALA0_S02e07492g 34684549 680963..681370 Unknown 1 NW_019212880.1 similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation; uncharacterized protein 681370 34684549 LALA0_S02e07492g Lachancea lanzarotensis uncharacterized protein XP_022627370.1 680963 D 1245769 CDS LALA0_S02e07514g 34684550 complement(681612..682844) Unknown 1 NW_019212880.1 similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene; uncharacterized protein 682844 34684550 LALA0_S02e07514g Lachancea lanzarotensis uncharacterized protein XP_022627371.1 681612 R 1245769 CDS LALA0_S02e07536g 34684551 complement(684103..684723) Unknown 1 NW_019212880.1 similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene; uncharacterized protein 684723 34684551 LALA0_S02e07536g Lachancea lanzarotensis uncharacterized protein XP_022627372.1 684103 R 1245769 CDS LALA0_S02e07558g 34684552 684910..685656 Unknown 1 NW_019212880.1 similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C ATP23 Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; uncharacterized protein 685656 34684552 LALA0_S02e07558g Lachancea lanzarotensis uncharacterized protein XP_022627373.1 684910 D 1245769 CDS LALA0_S02e07580g 34684553 complement(685777..687477) Unknown 1 NW_019212880.1 similar to uniprot|P25628 Saccharomyces cerevisiae YCR048W (ohnolog of YNR019W) ARE1 Acyl-CoA:sterolacyltransferase, isozyme of Are2p; endoplasmic reticulumenzyme that contributes the major sterol esterificationactivity in the absence of oxygen; sterol acyltransferase 687477 34684553 LALA0_S02e07580g Lachancea lanzarotensis sterol acyltransferase XP_022627374.1 685777 R 1245769 CDS LALA0_S02e07602g 34684554 688497..689303 Unknown 1 NW_019212880.1 highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern; 18S rRNA (guanine1575-N7)-methyltransferase 689303 34684554 LALA0_S02e07602g Lachancea lanzarotensis 18S rRNA (guanine1575-N7)-methyltransferase XP_022627375.1 688497 D 1245769 CDS LALA0_S02e07624g 34684555 689957..690481 Unknown 1 NW_019212880.1 similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome; mitochondrial 54S ribosomal protein bL19m 690481 34684555 LALA0_S02e07624g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL19m XP_022627376.1 689957 D 1245769 CDS LALA0_S02e07646g 34684556 complement(690733..691395) Unknown 1 NW_019212880.1 similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W AIM38 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss; uncharacterized protein 691395 34684556 LALA0_S02e07646g Lachancea lanzarotensis uncharacterized protein XP_022627377.1 690733 R 1245769 CDS LALA0_S02e07668g 34684557 692943..694535 Unknown 1 NW_019212880.1 similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores; uncharacterized protein 694535 34684557 LALA0_S02e07668g Lachancea lanzarotensis uncharacterized protein XP_022627378.1 692943 D 1245769 CDS LALA0_S02e07690g 34684558 complement(694987..695646) Unknown 1 NW_019212880.1 similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W TIM23 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; protein transporter TIM23 695646 34684558 LALA0_S02e07690g Lachancea lanzarotensis protein transporter TIM23 XP_022627379.1 694987 R 1245769 CDS LALA0_S02e07712g 34684559 700229..706924 Unknown 1 NW_019212880.1 highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C (ohnolog of YMR207C) ACC1 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids; acetyl-CoA carboxylase ACC1 706924 34684559 LALA0_S02e07712g Lachancea lanzarotensis acetyl-CoA carboxylase ACC1 XP_022627380.1 700229 D 1245769 CDS LALA0_S02e07734g 34684560 complement(707214..708377) Unknown 1 NW_019212880.1 similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs; tRNA-dihydrouridine(20) synthase (NAD(+)) 708377 34684560 LALA0_S02e07734g Lachancea lanzarotensis tRNA-dihydrouridine(20) synthase (NAD(+)) XP_022627381.1 707214 R 1245769 CDS LALA0_S02e07756g 34684561 709438..712914 Unknown 1 NW_019212880.1 weakly similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; uncharacterized protein 712914 34684561 LALA0_S02e07756g Lachancea lanzarotensis uncharacterized protein XP_022627382.1 709438 D 1245769 CDS LALA0_S02e07778g 34684562 complement(713092..713898) Unknown 1 NW_019212880.1 weakly similar to uniprot|P53719 Saccharomyces cerevisiae YNR014W (ohnolog of YMR206W) Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; uncharacterized protein 713898 34684562 LALA0_S02e07778g Lachancea lanzarotensis uncharacterized protein XP_022627383.1 713092 R 1245769 CDS LALA0_S02e07800g 34684563 717810..720257 Unknown 1 NW_019212880.1 similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; uncharacterized protein 720257 34684563 LALA0_S02e07800g Lachancea lanzarotensis uncharacterized protein XP_022627384.1 717810 D 1245769 CDS LALA0_S02e07822g 34684564 complement(720353..721807) Unknown 1 NW_019212880.1 similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP; uridine kinase URK1 721807 34684564 LALA0_S02e07822g Lachancea lanzarotensis uridine kinase URK1 XP_022627385.1 720353 R 1245769 CDS LALA0_S02e07844g 34684565 722020..724749 Unknown 1 NW_019212880.1 similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16; DEAH-box RNA-dependent ATPase PRP2 724749 34684565 LALA0_S02e07844g Lachancea lanzarotensis DEAH-box RNA-dependent ATPase PRP2 XP_022627386.1 722020 D 1245769 CDS LALA0_S02e07866g 34684566 725368..726408 Unknown 1 NW_019212880.1 similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress; lactoylglutathione lyase GLO1 726408 34684566 LALA0_S02e07866g Lachancea lanzarotensis lactoylglutathione lyase GLO1 XP_022627387.1 725368 D 1245769 CDS LALA0_S02e07888g 34684567 728249..731146 Unknown 1 NW_019212880.1 highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes; 6-phosphofructokinase subunit beta 731146 34684567 LALA0_S02e07888g Lachancea lanzarotensis 6-phosphofructokinase subunit beta XP_022627388.1 728249 D 1245769 CDS LALA0_S02e07910g 34684568 731509..732717 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03694 Saccharomyces cerevisiae YMR204C INP1 Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; uncharacterized protein 732717 34684568 LALA0_S02e07910g Lachancea lanzarotensis uncharacterized protein XP_022627389.1 731509 D 1245769 CDS LALA0_S02e07932g 34684569 complement(732996..734165) Unknown 1 NW_019212880.1 highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; uncharacterized protein 734165 34684569 LALA0_S02e07932g Lachancea lanzarotensis uncharacterized protein XP_022627390.1 732996 R 1245769 CDS LALA0_S02e07954g 34684570 complement(734554..734889) Unknown 1 NW_019212880.1 similar to uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; uncharacterized protein 734889 34684570 LALA0_S02e07954g Lachancea lanzarotensis uncharacterized protein XP_022627391.1 734554 R 1245769 CDS LALA0_S02e07976g 34684571 complement(735213..735884) Unknown 1 NW_019212880.1 highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; C-8 sterol isomerase ERG2 735884 34684571 LALA0_S02e07976g Lachancea lanzarotensis C-8 sterol isomerase ERG2 XP_022627392.1 735213 R 1245769 CDS LALA0_S02e07998g 34684572 complement(736221..736820) Unknown 1 NW_019212880.1 weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W NRM1 Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase; uncharacterized protein 736820 34684572 LALA0_S02e07998g Lachancea lanzarotensis uncharacterized protein XP_022627393.1 736221 R 1245769 CDS LALA0_S02e08020g 34684573 complement(737271..739223) Unknown 1 NW_019212880.1 similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase; phospholipid:diacylglycerol acyltransferase 739223 34684573 LALA0_S02e08020g Lachancea lanzarotensis phospholipid:diacylglycerol acyltransferase XP_022627394.1 737271 R 1245769 CDS LALA0_S02e08042g 34684574 739750..740685 Unknown 1 NW_019212880.1 similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; uncharacterized protein 740685 34684574 LALA0_S02e08042g Lachancea lanzarotensis uncharacterized protein XP_022627395.1 739750 D 1245769 CDS LALA0_S02e08064g 34684575 join(740866..740892,740965..741993) Unknown 1 NW_019212880.1 similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; DNA repair protein RAD14 741993 34684575 LALA0_S02e08064g Lachancea lanzarotensis DNA repair protein RAD14 XP_022627396.1 740866 D 1245769 CDS LALA0_S02e08086g 34684576 complement(742158..744023) Unknown 1 NW_019212880.1 similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p); ESCRT-0 subunit protein VPS27 744023 34684576 LALA0_S02e08086g Lachancea lanzarotensis ESCRT-0 subunit protein VPS27 XP_022627397.1 742158 R 1245769 CDS LALA0_S02e08108g 34684577 complement(744507..745259) Unknown 1 NW_019212880.1 similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; uncharacterized protein 745259 34684577 LALA0_S02e08108g Lachancea lanzarotensis uncharacterized protein XP_022627398.1 744507 R 1245769 CDS LALA0_S02e08130g 34684578 complement(745547..747073) Unknown 1 NW_019212880.1 similar to uniprot|P20438 Saccharomyces cerevisiae YPL256C (ohnolog of YMR199W) CLN2 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); cyclin CLN1 747073 34684578 LALA0_S02e08130g Lachancea lanzarotensis cyclin CLN1 XP_022627399.1 745547 R 1245769 CDS LALA0_S02e08152g 34684579 complement(747730..748923) Unknown 1 NW_019212880.1 weakly similar to Lachancea thermotolerans KLTH0C10164g hypothetical protein; uncharacterized protein 748923 34684579 LALA0_S02e08152g Lachancea lanzarotensis uncharacterized protein XP_022627400.1 747730 R 1245769 CDS LALA0_S02e08174g 34684580 749148..750314 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; uncharacterized protein 750314 34684580 LALA0_S02e08174g Lachancea lanzarotensis uncharacterized protein XP_022627401.1 749148 D 1245769 CDS LALA0_S02e08196g 34684581 750836..752143 Unknown 1 NW_019212880.1 similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; uncharacterized protein 752143 34684581 LALA0_S02e08196g Lachancea lanzarotensis uncharacterized protein XP_022627402.1 750836 D 1245769 CDS LALA0_S02e08218g 34684582 complement(752233..754122) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12045 Saccharomyces cerevisiae YPL253C (ohnolog of YMR198W) VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p; uncharacterized protein 754122 34684582 LALA0_S02e08218g Lachancea lanzarotensis uncharacterized protein XP_022627403.1 752233 R 1245769 CDS LALA0_S02e08240g 34684583 complement(754512..754991) Unknown 1 NW_019212880.1 similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin; adrenodoxin 754991 34684583 LALA0_S02e08240g Lachancea lanzarotensis adrenodoxin XP_022627404.1 754512 R 1245769 CDS LALA0_S02e08262g 34684584 755903..756568 Unknown 1 NW_019212880.1 highly similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; v-SNARE protein VTI1 756568 34684584 LALA0_S02e08262g Lachancea lanzarotensis v-SNARE protein VTI1 XP_022627405.1 755903 D 1245769 CDS LALA0_S02e08284g 34684585 complement(756806..760054) Unknown 1 NW_019212880.1 highly similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene; uncharacterized protein 760054 34684585 LALA0_S02e08284g Lachancea lanzarotensis uncharacterized protein XP_022627406.1 756806 R 1245769 CDS LALA0_S02e08306g 34684586 complement(761712..762059) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q04329 Saccharomyces cerevisiae YMR195W (ohnolog of YPL250C) ICY1 Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; uncharacterized protein 762059 34684586 LALA0_S02e08306g Lachancea lanzarotensis uncharacterized protein XP_022627407.1 761712 R 1245769 CDS LALA0_S02e08328g 34684587 complement(764144..765040) Unknown 1 NW_019212880.1 similar to uniprot|G8ZSK1 Torulaspora delbrueckii TDEL0D00110 hypothetical protein; uncharacterized protein 765040 34684587 LALA0_S02e08328g Lachancea lanzarotensis uncharacterized protein XP_022627408.1 764144 R 1245769 CDS LALA0_S02e08350g 34684588 768465..769061 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03125 Saccharomyces cerevisiae YDR043C (ohnolog of YBR066C) NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; uncharacterized protein 769061 34684588 LALA0_S02e08350g Lachancea lanzarotensis uncharacterized protein XP_022627409.1 768465 D 1245769 CDS LALA0_S02e08372g 34684589 774526..775080 Unknown 1 NW_019212880.1 weakly similar to uniprot|C5DE93 Lachancea thermotolerans KLTH0C07282g hypothetical protein; uncharacterized protein 775080 34684589 LALA0_S02e08372g Lachancea lanzarotensis uncharacterized protein XP_022627410.1 774526 D 1245769 CDS LALA0_S02e08394g 34684590 776162..777145 Unknown 1 NW_019212880.1 highly similar to uniprot|P11353 Saccharomyces cerevisiae YDR044W HEM13 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); coproporphyrinogen oxidase 777145 34684590 LALA0_S02e08394g Lachancea lanzarotensis coproporphyrinogen oxidase XP_022627411.1 776162 D 1245769 CDS LALA0_S02e08416g 34684591 complement(777523..777855) Unknown 1 NW_019212880.1 highly similar to uniprot|Q04307 Saccharomyces cerevisiae YDR045C RPC11 RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS; DNA-directed RNA polymerase III core subunit RPC11 777855 34684591 LALA0_S02e08416g Lachancea lanzarotensis DNA-directed RNA polymerase III core subunit RPC11 XP_022627412.1 777523 R 1245769 CDS LALA0_S02e08438g 34684592 778914..780773 Unknown 1 NW_019212880.1 similar to uniprot|P32833 Saccharomyces cerevisiae YBR060C ORC2 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p; origin recognition complex subunit 2 780773 34684592 LALA0_S02e08438g Lachancea lanzarotensis origin recognition complex subunit 2 XP_022627413.1 778914 D 1245769 CDS LALA0_S02e08460g 34684593 781091..783520 Unknown 1 NW_019212880.1 weakly similar to uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization; serine/threonine protein kinase AKL1 783520 34684593 LALA0_S02e08460g Lachancea lanzarotensis serine/threonine protein kinase AKL1 XP_022627414.1 781091 D 1245769 CDS LALA0_S02e08482g 34684594 783687..783941 Unknown 1 NW_019212880.1 similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis; uncharacterized protein 783941 34684594 LALA0_S02e08482g Lachancea lanzarotensis uncharacterized protein XP_022627415.1 783687 D 1245769 CDS LALA0_S02e08504g 34684595 complement(784203..785354) Unknown 1 NW_019212880.1 highly similar to uniprot|C5DE93 Lachancea thermotolerans KLTH0C07282g hypothetical protein; uncharacterized protein 785354 34684595 LALA0_S02e08504g Lachancea lanzarotensis uncharacterized protein XP_022627416.1 784203 R 1245769 CDS LALA0_S02e08526g 34684596 786590..788041 Unknown 1 NW_019212880.1 similar to uniprot|P28817 Saccharomyces cerevisiae YDR036C EHD3 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; mitochondrial 37S ribosomal protein mS47 788041 34684596 LALA0_S02e08526g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS47 XP_022627417.1 786590 D 1245769 CDS LALA0_S02e08548g 34684597 788278..790590 Unknown 1 NW_019212880.1 similar to uniprot|P38237 Saccharomyces cerevisiae YBR058C UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; ubiquitin-specific protease UBP14 790590 34684597 LALA0_S02e08548g Lachancea lanzarotensis ubiquitin-specific protease UBP14 XP_022627418.1 788278 D 1245769 CDS LALA0_S02e08570g 34684598 join(790780..790824,790895..791797) Unknown 1 NW_019212880.1 weakly similar to uniprot|P38236 Saccharomyces cerevisiae YBR057C MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex; uncharacterized protein 791797 34684598 LALA0_S02e08570g Lachancea lanzarotensis uncharacterized protein XP_022627419.1 790780 D 1245769 CDS LALA0_S02e08592g 34684599 complement(791984..793102) Unknown 1 NW_019212880.1 highly similar to uniprot|P14843 Saccharomyces cerevisiae YDR035W ARO3 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan; 3-deoxy-7-phosphoheptulonate synthase ARO3 793102 34684599 LALA0_S02e08592g Lachancea lanzarotensis 3-deoxy-7-phosphoheptulonate synthase ARO3 XP_022627420.1 791984 R 1245769 CDS LALA0_S02e08636g 34684601 complement(794171..795655) Unknown 1 NW_019212880.1 similar to uniprot|P38081 Saccharomyces cerevisiae YBR056W Putative cytoplasmic protein of unknown function; 17-beta-hydroxysteroid dehydrogenase-like protein 795655 34684601 LALA0_S02e08636g Lachancea lanzarotensis 17-beta-hydroxysteroid dehydrogenase-like protein XP_022627421.1 794171 R 1245769 CDS LALA0_S02e08658g 34684602 complement(796240..797265) Unknown 1 NW_019212880.1 similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Putative protein of unknown function; induced by cell wall perturbation; uncharacterized protein 797265 34684602 LALA0_S02e08658g Lachancea lanzarotensis uncharacterized protein XP_022627422.1 796240 R 1245769 CDS LALA0_S02e08680g 34684603 complement(797787..799286) Unknown 1 NW_019212880.1 weakly similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W ERC1 Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine; uncharacterized protein 799286 34684603 LALA0_S02e08680g Lachancea lanzarotensis uncharacterized protein XP_022627423.1 797787 R 1245769 CDS LALA0_S02e08702g 34684604 799853..801121 Unknown 1 NW_019212880.1 weakly similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance; uncharacterized protein 801121 34684604 LALA0_S02e08702g Lachancea lanzarotensis uncharacterized protein XP_022627424.1 799853 D 1245769 CDS LALA0_S02e08724g 34684605 complement(801195..803540) Unknown 1 NW_019212880.1 similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer; uncharacterized protein 803540 34684605 LALA0_S02e08724g Lachancea lanzarotensis uncharacterized protein XP_022627425.1 801195 R 1245769 CDS LALA0_S02e08746g 34684606 complement(803624..806353) Unknown 1 NW_019212880.1 similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor, component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP6 806353 34684606 LALA0_S02e08746g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP6 XP_022627426.1 803624 R 1245769 CDS LALA0_S02e08768g 34684607 807527..808129 Unknown 1 NW_019212880.1 highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C (ohnolog of YBR052C) PST2 Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; flavodoxin-like fold family protein 808129 34684607 LALA0_S02e08768g Lachancea lanzarotensis flavodoxin-like fold family protein XP_022627427.1 807527 D 1245769 CDS LALA0_S02e08790g 34684608 complement(808292..808630) Unknown 1 NW_019212880.1 similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W MIC14 Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 808630 34684608 LALA0_S02e08790g Lachancea lanzarotensis uncharacterized protein XP_022627428.1 808292 R 1245769 CDS LALA0_S02e08812g 34684609 808681..809148 Unknown 1 NW_019212880.1 hypothetical protein; uncharacterized protein 809148 34684609 LALA0_S02e08812g Lachancea lanzarotensis uncharacterized protein XP_022627429.1 808681 D 1245769 CDS LALA0_S02e08834g 34684610 809187..810482 Unknown 1 NW_019212880.1 similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair; uncharacterized protein 810482 34684610 LALA0_S02e08834g Lachancea lanzarotensis uncharacterized protein XP_022627430.1 809187 D 1245769 CDS LALA0_S02e08856g 34684611 811898..814639 Unknown 1 NW_019212880.1 similar to uniprot|P38232 Saccharomyces cerevisiae YBR050C (ohnolog of YDR028C) REG2 Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; protein phosphatase regulator REG1 814639 34684611 LALA0_S02e08856g Lachancea lanzarotensis protein phosphatase regulator REG1 XP_022627431.1 811898 D 1245769 CDS LALA0_S02e08878g 34684612 814953..817643 Unknown 1 NW_019212880.1 similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p; uncharacterized protein 817643 34684612 LALA0_S02e08878g Lachancea lanzarotensis uncharacterized protein XP_022627432.1 814953 D 1245769 CDS LALA0_S02e08900g 34684613 819037..821166 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12457 Saccharomyces cerevisiae YDR026C (ohnolog of YBR049C) Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p; uncharacterized protein 821166 34684613 LALA0_S02e08900g Lachancea lanzarotensis uncharacterized protein XP_022627433.1 819037 D 1245769 CDS LALA0_S02e08922g 34684614 complement(join(821398..821823,822163..822207)) Unknown 1 NW_019212880.1 highly similar to uniprot|P0CX47 Saccharomyces cerevisiae YDR025W (ohnolog of YBR048W) RPS11A Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins; 40S ribosomal protein uS17 822207 34684614 LALA0_S02e08922g Lachancea lanzarotensis 40S ribosomal protein uS17 XP_022627434.1 821398 R 1245769 CDS LALA0_S02e08944g 34684615 823449..825908 Unknown 1 NW_019212880.1 weakly similar to uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p; protein phosphatase regulator GIP1 825908 34684615 LALA0_S02e08944g Lachancea lanzarotensis protein phosphatase regulator GIP1 XP_022627435.1 823449 D 1245769 CDS LALA0_S02e08966g 34684616 complement(826158..827549) Unknown 1 NW_019212880.1 highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p; serine--tRNA ligase SES1 827549 34684616 LALA0_S02e08966g Lachancea lanzarotensis serine--tRNA ligase SES1 XP_022627436.1 826158 R 1245769 CDS LALA0_S02e09010g 34684618 829412..829825 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion; uncharacterized protein 829825 34684618 LALA0_S02e09010g Lachancea lanzarotensis uncharacterized protein XP_022627437.1 829412 D 1245769 CDS LALA0_S02e09032g 34684619 complement(829907..831106) Unknown 1 NW_019212880.1 highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; ATP-dependent RNA helicase FAL1 831106 34684619 LALA0_S02e09032g Lachancea lanzarotensis ATP-dependent RNA helicase FAL1 XP_022627438.1 829907 R 1245769 CDS LALA0_S02e09054g 34684620 831276..831923 Unknown 1 NW_019212880.1 similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C DAS2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases; uncharacterized protein 831923 34684620 LALA0_S02e09054g Lachancea lanzarotensis uncharacterized protein XP_022627439.1 831276 D 1245769 CDS LALA0_S02e09076g 34684621 832338..833993 Unknown 1 NW_019212880.1 similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone; uncharacterized protein 833993 34684621 LALA0_S02e09076g Lachancea lanzarotensis uncharacterized protein XP_022627440.1 832338 D 1245769 CDS LALA0_S02e09098g 34684622 834445..835635 Unknown 1 NW_019212880.1 similar to uniprot|P48015 Saccharomyces cerevisiae YDR019C GCV1 T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; glycine decarboxylase subunit T 835635 34684622 LALA0_S02e09098g Lachancea lanzarotensis glycine decarboxylase subunit T XP_022627441.1 834445 D 1245769 CDS LALA0_S02e09120g 34684623 836156..837904 Unknown 1 NW_019212880.1 highly similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p; uncharacterized protein 837904 34684623 LALA0_S02e09120g Lachancea lanzarotensis uncharacterized protein XP_022627442.1 836156 D 1245769 CDS LALA0_S02e09142g 34684624 838617..840581 Unknown 1 NW_019212880.1 similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin; uncharacterized protein 840581 34684624 LALA0_S02e09142g Lachancea lanzarotensis uncharacterized protein XP_022627443.1 838617 D 1245769 CDS LALA0_S02e09164g 34684625 841134..842339 Unknown 1 NW_019212880.1 similar to uniprot|Q12185 Saccharomyces cerevisiae YDR018C (ohnolog of YBR042C) Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; uncharacterized protein 842339 34684625 LALA0_S02e09164g Lachancea lanzarotensis uncharacterized protein XP_022627444.1 841134 D 1245769 CDS LALA0_S02e09186g 34684626 complement(842467..844476) Unknown 1 NW_019212880.1 similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids; long-chain fatty acid transporter FAT1 844476 34684626 LALA0_S02e09186g Lachancea lanzarotensis long-chain fatty acid transporter FAT1 XP_022627445.1 842467 R 1245769 CDS LALA0_S02e09208g 34684627 complement(844711..845601) Unknown 1 NW_019212880.1 similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; uncharacterized protein 845601 34684627 LALA0_S02e09208g Lachancea lanzarotensis uncharacterized protein XP_022627446.1 844711 R 1245769 CDS LALA0_S02e09230g 34684628 complement(846392..847273) Unknown 1 NW_019212880.1 similar to uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit gamma 847273 34684628 LALA0_S02e09230g Lachancea lanzarotensis F1F0 ATP synthase subunit gamma XP_022627447.1 846392 R 1245769 CDS LALA0_S02e09252g 34684629 848639..851395 Unknown 1 NW_019212880.1 similar to uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance; inositol polyphosphate kinase KCS1 851395 34684629 LALA0_S02e09252g Lachancea lanzarotensis inositol polyphosphate kinase KCS1 XP_022627448.1 848639 D 1245769 CDS LALA0_S02e09274g 34684630 851830..852108 Unknown 1 NW_019212880.1 similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 852108 34684630 LALA0_S02e09274g Lachancea lanzarotensis uncharacterized protein XP_022627449.1 851830 D 1245769 CDS LALA0_S02e09318g 34684632 complement(852764..853918) Unknown 1 NW_019212880.1 weakly similar to uniprot|C5DED9 Lachancea thermotolerans KLTH0C08404g hypothetical protein; uncharacterized protein 853918 34684632 LALA0_S02e09318g Lachancea lanzarotensis uncharacterized protein XP_022627450.1 852764 R 1245769 CDS LALA0_S02e09340g 34684633 855772..856824 Unknown 1 NW_019212880.1 similar to uniprot|Q08913 Saccharomyces cerevisiae YOR390W Putative protein of unknown function; uncharacterized protein 856824 34684633 LALA0_S02e09340g Lachancea lanzarotensis uncharacterized protein XP_022627451.1 855772 D 1245769 CDS LALA0_S02e09362g 34684634 join(857094..857133,857202..857848) Unknown 1 NW_019212880.1 highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism; pyridoxamine-phosphate oxidase PDX3 857848 34684634 LALA0_S02e09362g Lachancea lanzarotensis pyridoxamine-phosphate oxidase PDX3 XP_022627452.1 857094 D 1245769 CDS LALA0_S02e09384g 34684635 complement(857923..859704) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin; uncharacterized protein 859704 34684635 LALA0_S02e09384g Lachancea lanzarotensis uncharacterized protein XP_022627453.1 857923 R 1245769 CDS LALA0_S02e09406g 34684636 859863..860477 Unknown 1 NW_019212880.1 highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; DNA replication protein PSF1 860477 34684636 LALA0_S02e09406g Lachancea lanzarotensis DNA replication protein PSF1 XP_022627454.1 859863 D 1245769 CDS LALA0_S02e09428g 34684637 860896..861369 Unknown 1 NW_019212880.1 similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL59 861369 34684637 LALA0_S02e09428g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL59 XP_022627455.1 860896 D 1245769 CDS LALA0_S02e09450g 34684638 861584..862321 Unknown 1 NW_019212880.1 similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly; U4/U6-U5 snRNP complex subunit PRP38 862321 34684638 LALA0_S02e09450g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP38 XP_022627456.1 861584 D 1245769 CDS LALA0_S02e09472g 34684639 complement(862480..862899) Unknown 1 NW_019212880.1 similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; mRNA splicing protein SMD1 862899 34684639 LALA0_S02e09472g Lachancea lanzarotensis mRNA splicing protein SMD1 XP_022627457.1 862480 R 1245769 CDS LALA0_S02e09494g 34684640 863729..864376 Unknown 1 NW_019212880.1 similar to Lachancea thermotolerans KLTH0C08624g hypothetical protein; uncharacterized protein 864376 34684640 LALA0_S02e09494g Lachancea lanzarotensis uncharacterized protein XP_022627458.1 863729 D 1245769 CDS LALA0_S02e09516g 34684641 complement(864510..865685) Unknown 1 NW_019212880.1 weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance; uncharacterized protein 865685 34684641 LALA0_S02e09516g Lachancea lanzarotensis uncharacterized protein XP_022627459.1 864510 R 1245769 CDS LALA0_S02e09538g 34684642 865812..867212 Unknown 1 NW_019212880.1 similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding; uncharacterized protein 867212 34684642 LALA0_S02e09538g Lachancea lanzarotensis uncharacterized protein XP_022627460.1 865812 D 1245769 CDS LALA0_S02e09560g 34684643 867820..868749 Unknown 1 NW_019212880.1 highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; type 2A-related serine/threonine-protein phosphatase SIT4 868749 34684643 LALA0_S02e09560g Lachancea lanzarotensis type 2A-related serine/threonine-protein phosphatase SIT4 XP_022627461.1 867820 D 1245769 CDS LALA0_S02e09582g 34684644 869544..870065 Unknown 1 NW_019212880.1 similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; sterol transporter 870065 34684644 LALA0_S02e09582g Lachancea lanzarotensis sterol transporter XP_022627462.1 869544 D 1245769 CDS LALA0_S02e09604g 34684645 870505..870954 Unknown 1 NW_019212880.1 similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma); succinate dehydrogenase assembly factor SDH5 870954 34684645 LALA0_S02e09604g Lachancea lanzarotensis succinate dehydrogenase assembly factor SDH5 XP_022627463.1 870505 D 1245769 CDS LALA0_S02e09626g 34684646 871495..871782 Unknown 1 NW_019212880.1 highly similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; mitochondrial 37S ribosomal protein mS37 871782 34684646 LALA0_S02e09626g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS37 XP_022627464.1 871495 D 1245769 CDS LALA0_S02e09648g 34684647 complement(871913..872833) Unknown 1 NW_019212880.1 similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin; FMN adenylyltransferase 872833 34684647 LALA0_S02e09648g Lachancea lanzarotensis FMN adenylyltransferase XP_022627465.1 871913 R 1245769 CDS LALA0_S02e09670g 34684648 complement(873026..874321) Unknown 1 NW_019212880.1 weakly similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription; uncharacterized protein 874321 34684648 LALA0_S02e09670g Lachancea lanzarotensis uncharacterized protein XP_022627466.1 873026 R 1245769 CDS LALA0_S02e09692g 34684649 complement(874913..876685) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C NBA1 Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate; uncharacterized protein 876685 34684649 LALA0_S02e09692g Lachancea lanzarotensis uncharacterized protein XP_022627467.1 874913 R 1245769 CDS LALA0_S02e09714g 34684650 complement(876974..878683) Unknown 1 NW_019212880.1 similar to uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein; uncharacterized protein 878683 34684650 LALA0_S02e09714g Lachancea lanzarotensis uncharacterized protein XP_022627468.1 876974 R 1245769 CDS LALA0_S02e09736g 34684651 879001..880344 Unknown 1 NW_019212880.1 similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; kinetochore-associated Ndc80 complex subunit NUF2 880344 34684651 LALA0_S02e09736g Lachancea lanzarotensis kinetochore-associated Ndc80 complex subunit NUF2 XP_022627469.1 879001 D 1245769 CDS LALA0_S02e09758g 34684652 complement(880400..881161) Unknown 1 NW_019212880.1 similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; uncharacterized protein 881161 34684652 LALA0_S02e09758g Lachancea lanzarotensis uncharacterized protein XP_022627470.1 880400 R 1245769 CDS LALA0_S02e09780g 34684653 complement(881436..883142) Unknown 1 NW_019212880.1 similar to uniprot|P06700 Saccharomyces cerevisiae YDL042C (ohnolog of YOL068C) SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; NAD-dependent histone deacetylase SIR2 883142 34684653 LALA0_S02e09780g Lachancea lanzarotensis NAD-dependent histone deacetylase SIR2 XP_022627471.1 881436 R 1245769 CDS LALA0_S02e09802g 34684654 complement(883619..884179) Unknown 1 NW_019212880.1 similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus; uncharacterized protein 884179 34684654 LALA0_S02e09802g Lachancea lanzarotensis uncharacterized protein XP_022627472.1 883619 R 1245769 CDS LALA0_S02e09824g 34684655 complement(884517..887060) Unknown 1 NW_019212880.1 similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; peptide alpha-N-acetyltransferase complex A subunit NAT1 887060 34684655 LALA0_S02e09824g Lachancea lanzarotensis peptide alpha-N-acetyltransferase complex A subunit NAT1 XP_022627473.1 884517 R 1245769 CDS LALA0_S02e09846g 34684656 complement(887264..889105) Unknown 1 NW_019212880.1 similar to uniprot|Q12069 Saccharomyces cerevisiae YDL036C (ohnolog of YOL066C) PUS9 Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; uncharacterized protein 889105 34684656 LALA0_S02e09846g Lachancea lanzarotensis uncharacterized protein XP_022627474.1 887264 R 1245769 CDS LALA0_S02e09868g 34684657 complement(889287..890411) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins; phosphoinositide 5-phosphatase INP54 890411 34684657 LALA0_S02e09868g Lachancea lanzarotensis phosphoinositide 5-phosphatase INP54 XP_022627475.1 889287 R 1245769 CDS LALA0_S02e09890g 34684658 complement(890820..893624) Unknown 1 NW_019212880.1 similar to uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; uncharacterized protein 893624 34684658 LALA0_S02e09890g Lachancea lanzarotensis uncharacterized protein XP_022627476.1 890820 R 1245769 CDS LALA0_S02e09912g 34684659 complement(894405..895484) Unknown 1 NW_019212880.1 weakly similar to uniprot|M2N9U1 Baudoinia compniacensis BAUCODRAFT_24881 hypothetical protein; uncharacterized protein 895484 34684659 LALA0_S02e09912g Lachancea lanzarotensis uncharacterized protein XP_022627477.1 894405 R 1245769 CDS LALA0_S02e09934g 34684660 complement(895953..897038) Unknown 1 NW_019212880.1 similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; 3'(2'),5'-bisphosphate nucleotidase 897038 34684660 LALA0_S02e09934g Lachancea lanzarotensis 3'(2'),5'-bisphosphate nucleotidase XP_022627478.1 895953 R 1245769 CDS LALA0_S02e09956g 34684661 complement(897761..899005) Unknown 1 NW_019212880.1 similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF); tRNA-5-taurinomethyluridine 2-sulfurtransferase 899005 34684661 LALA0_S02e09956g Lachancea lanzarotensis tRNA-5-taurinomethyluridine 2-sulfurtransferase XP_022627479.1 897761 R 1245769 CDS LALA0_S02e09978g 34684662 899269..902217 Unknown 1 NW_019212880.1 highly similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; uncharacterized protein 902217 34684662 LALA0_S02e09978g Lachancea lanzarotensis uncharacterized protein XP_022627480.1 899269 D 1245769 CDS LALA0_S02e10000g 34684663 902452..903996 Unknown 1 NW_019212880.1 similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; SF3a splicing factor complex subunit PRP9 903996 34684663 LALA0_S02e10000g Lachancea lanzarotensis SF3a splicing factor complex subunit PRP9 XP_022627481.1 902452 D 1245769 CDS LALA0_S02e10022g 34684664 904269..905585 Unknown 1 NW_019212880.1 similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; phosphatidate cytidylyltransferase 905585 34684664 LALA0_S02e10022g Lachancea lanzarotensis phosphatidate cytidylyltransferase XP_022627482.1 904269 D 1245769 CDS LALA0_S02e10044g 34684665 complement(905672..906502) Unknown 1 NW_019212880.1 weakly similar to Lachancea thermotolerans KLTH0C08954g hypothetical protein; uncharacterized protein 906502 34684665 LALA0_S02e10044g Lachancea lanzarotensis uncharacterized protein XP_022627483.1 905672 R 1245769 CDS LALA0_S02e10066g 34684666 908204..909721 Unknown 1 NW_019212880.1 similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C YPK3 An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; uncharacterized protein 909721 34684666 LALA0_S02e10066g Lachancea lanzarotensis uncharacterized protein XP_022627484.1 908204 D 1245769 CDS LALA0_S02e10088g 34684667 complement(909827..910177) Unknown 1 NW_019212880.1 similar to uniprot|C5DEI6 Lachancea thermotolerans KLTH0C09526g hypothetical protein; uncharacterized protein 910177 34684667 LALA0_S02e10088g Lachancea lanzarotensis uncharacterized protein XP_022627485.1 909827 R 1245769 CDS LALA0_S02e10110g 34684668 911403..913523 Unknown 1 NW_019212880.1 weakly similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; uncharacterized protein 913523 34684668 LALA0_S02e10110g Lachancea lanzarotensis uncharacterized protein XP_022627486.1 911403 D 1245769 CDS LALA0_S02e10132g 34684669 913805..914974 Unknown 1 NW_019212880.1 similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis; enoyl-[acyl-carrier-protein] reductase 914974 34684669 LALA0_S02e10132g Lachancea lanzarotensis enoyl-[acyl-carrier-protein] reductase XP_022627487.1 913805 D 1245769 CDS LALA0_S02e10154g 34684670 complement(915079..916233) Unknown 1 NW_019212880.1 similar to uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; mannosylinositol phosphorylceramide synthase regulatory subunit 916233 34684670 LALA0_S02e10154g Lachancea lanzarotensis mannosylinositol phosphorylceramide synthase regulatory subunit XP_022627488.1 915079 R 1245769 CDS LALA0_S02e10198g 34684672 complement(join(916649..916785,916858..917080)) Unknown 1 NW_019212880.1 weakly similar to uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain; uncharacterized protein 917080 34684672 LALA0_S02e10198g Lachancea lanzarotensis uncharacterized protein XP_022627489.1 916649 R 1245769 CDS LALA0_S02e10242g 34684674 complement(917780..918655) Unknown 1 NW_019212880.1 similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels; mitochondrial 54S ribosomal protein uL15m 918655 34684674 LALA0_S02e10242g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL15m XP_022627490.1 917780 R 1245769 CDS LALA0_S02e10286g 34684676 complement(919107..920360) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12215 Saccharomyces cerevisiae YOL105C (ohnolog of YNL283C) WSC3 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; uncharacterized protein 920360 34684676 LALA0_S02e10286g Lachancea lanzarotensis uncharacterized protein XP_022627491.1 919107 R 1245769 CDS LALA0_S02e10308g 34684677 922620..923225 Unknown 1 NW_019212880.1 similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; uncharacterized protein 923225 34684677 LALA0_S02e10308g Lachancea lanzarotensis uncharacterized protein XP_022627492.1 922620 D 1245769 CDS LALA0_S02e10330g 34684678 923504..923950 Unknown 1 NW_019212880.1 similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; uncharacterized protein 923950 34684678 LALA0_S02e10330g Lachancea lanzarotensis uncharacterized protein XP_022627493.1 923504 D 1245769 CDS LALA0_S02e10352g 34684679 complement(924068..925390) Unknown 1 NW_019212880.1 highly similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions; delta(14)-sterol reductase 925390 34684679 LALA0_S02e10352g Lachancea lanzarotensis delta(14)-sterol reductase XP_022627494.1 924068 R 1245769 CDS LALA0_S02e10374g 34684680 complement(925666..926685) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement; uncharacterized protein 926685 34684680 LALA0_S02e10374g Lachancea lanzarotensis uncharacterized protein XP_022627495.1 925666 R 1245769 CDS LALA0_S02e10396g 34684681 927044..928054 Unknown 1 NW_019212880.1 weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p; uncharacterized protein 928054 34684681 LALA0_S02e10396g Lachancea lanzarotensis uncharacterized protein XP_022627496.1 927044 D 1245769 CDS LALA0_S02e10418g 34684682 929790..931517 Unknown 1 NW_019212880.1 similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; myo-inositol transporter ITR1 931517 34684682 LALA0_S02e10418g Lachancea lanzarotensis myo-inositol transporter ITR1 XP_022627497.1 929790 D 1245769 CDS LALA0_S02e10440g 34684683 931998..933992 Unknown 1 NW_019212880.1 similar to uniprot|Q04373 Saccharomyces cerevisiae YDR496C PUF6 Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis; uncharacterized protein 933992 34684683 LALA0_S02e10440g Lachancea lanzarotensis uncharacterized protein XP_022627498.1 931998 D 1245769 CDS LALA0_S02e10462g 34684684 934187..936979 Unknown 1 NW_019212880.1 weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase; CORVET complex subunit VPS3 936979 34684684 LALA0_S02e10462g Lachancea lanzarotensis CORVET complex subunit VPS3 XP_022627499.1 934187 D 1245769 CDS LALA0_S02e10484g 34684685 complement(937042..938130) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation; uncharacterized protein 938130 34684685 LALA0_S02e10484g Lachancea lanzarotensis uncharacterized protein XP_022627500.1 937042 R 1245769 CDS LALA0_S02e10506g 34684686 complement(938614..939312) Unknown 1 NW_019212880.1 similar to uniprot|Q12272 Saccharomyces cerevisiae YOL102C TPT1 tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide; tRNA 2'-phosphotransferase 939312 34684686 LALA0_S02e10506g Lachancea lanzarotensis tRNA 2'-phosphotransferase XP_022627501.1 938614 R 1245769 CDS LALA0_S02e10528g 34684687 complement(939592..939948) Unknown 1 NW_019212880.1 similar to uniprot|Q03429 Saccharomyces cerevisiae YDR493W MZM1 Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool; null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss; overexpression causes cell cycle delay or arrest; uncharacterized protein 939948 34684687 LALA0_S02e10528g Lachancea lanzarotensis uncharacterized protein XP_022627502.1 939592 R 1245769 CDS LALA0_S02e10550g 34684688 complement(940637..941599) Unknown 1 NW_019212880.1 similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W (ohnolog of YOL101C) IZH1 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; PAQR-type receptor 941599 34684688 LALA0_S02e10550g Lachancea lanzarotensis PAQR-type receptor XP_022627503.1 940637 R 1245769 CDS LALA0_S02e10572g 34684689 complement(942031..942591) Unknown 1 NW_019212880.1 weakly similar to uniprot|C5DEI6 Lachancea thermotolerans KLTH0C09526g hypothetical protein; uncharacterized protein 942591 34684689 LALA0_S02e10572g Lachancea lanzarotensis uncharacterized protein XP_022627504.1 942031 R 1245769 CDS LALA0_S02e10594g 34684690 943109..946093 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03407 Saccharomyces cerevisiae YDR490C (ohnolog of YOL100W) PKH1 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p; serine/threonine protein kinase PKH1 946093 34684690 LALA0_S02e10594g Lachancea lanzarotensis serine/threonine protein kinase PKH1 XP_022627505.1 943109 D 1245769 CDS LALA0_S02e10616g 34684691 complement(946469..949573) Unknown 1 NW_019212880.1 similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Putative metalloprotease; uncharacterized protein 949573 34684691 LALA0_S02e10616g Lachancea lanzarotensis uncharacterized protein XP_022627506.1 946469 R 1245769 CDS LALA0_S02e10638g 34684692 950468..950986 Unknown 1 NW_019212880.1 hypothetical protein; uncharacterized protein 950986 34684692 LALA0_S02e10638g Lachancea lanzarotensis uncharacterized protein XP_022627507.1 950468 D 1245769 CDS LALA0_S02e10660g 34684693 951471..952193 Unknown 1 NW_019212880.1 weakly similar to uniprot|P38195 Saccharomyces cerevisiae YBL043W (ohnolog of YJR115W) ECM13 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; uncharacterized protein 952193 34684693 LALA0_S02e10660g Lachancea lanzarotensis uncharacterized protein XP_022627508.1 951471 D 1245769 CDS LALA0_S02e10682g 34684694 952967..954706 Unknown 1 NW_019212880.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions; uncharacterized protein 954706 34684694 LALA0_S02e10682g Lachancea lanzarotensis uncharacterized protein XP_022627509.1 952967 D 1245769 CDS LALA0_S02e10704g 34684695 954965..955693 Unknown 1 NW_019212880.1 highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 Beta 6 subunit of the 20S proteasome; proteasome core particle subunit beta 6 955693 34684695 LALA0_S02e10704g Lachancea lanzarotensis proteasome core particle subunit beta 6 XP_022627510.1 954965 D 1245769 CDS LALA0_S02e10726g 34684696 complement(955799..956458) Unknown 1 NW_019212880.1 similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins; uncharacterized protein 956458 34684696 LALA0_S02e10726g Lachancea lanzarotensis uncharacterized protein XP_022627511.1 955799 R 1245769 CDS LALA0_S02e10748g 34684697 complement(956744..957853) Unknown 1 NW_019212880.1 weakly similar to Lachancea thermotolerans KLTH0E02024g hypothetical protein; uncharacterized protein 957853 34684697 LALA0_S02e10748g Lachancea lanzarotensis uncharacterized protein XP_022627512.1 956744 R 1245769 CDS LALA0_S02e10770g 34684698 957996..958157 Unknown 1 NW_019212880.1 similar to uniprot|P0C268 Saccharomyces cerevisiae YBL039W-B Putative protein of unknown function; uncharacterized protein 958157 34684698 LALA0_S02e10770g Lachancea lanzarotensis uncharacterized protein XP_022627513.1 957996 D 1245769 CDS LALA0_S02e10792g 34684699 join(958184..958268,958770..959221) Unknown 1 NW_019212880.1 similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; superoxide dismutase SOD1 959221 34684699 LALA0_S02e10792g Lachancea lanzarotensis superoxide dismutase SOD1 XP_022627514.1 958184 D 1245769 CDS LALA0_S02e10814g 34684700 complement(959459..961189) Unknown 1 NW_019212880.1 highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C (ohnolog of YJR103W) URA7 Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; uncharacterized protein 961189 34684700 LALA0_S02e10814g Lachancea lanzarotensis uncharacterized protein XP_022627515.1 959459 R 1245769 CDS LALA0_S02e10836g 34684701 complement(962891..963451) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; uncharacterized protein 963451 34684701 LALA0_S02e10836g Lachancea lanzarotensis uncharacterized protein XP_022627516.1 962891 R 1245769 CDS LALA0_S02e10858g 34684702 963564..964106 Unknown 1 NW_019212880.1 similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; ESCRT-II subunit protein VPS25 964106 34684702 LALA0_S02e10858g Lachancea lanzarotensis ESCRT-II subunit protein VPS25 XP_022627517.1 963564 D 1245769 CDS LALA0_S02e10880g 34684703 complement(964258..965013) Unknown 1 NW_019212880.1 similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS42 965013 34684703 LALA0_S02e10880g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS42 XP_022627518.1 964258 R 1245769 CDS LALA0_S02e10902g 34684704 965879..966862 Unknown 1 NW_019212880.1 similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C AIM25 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss; uncharacterized protein 966862 34684704 LALA0_S02e10902g Lachancea lanzarotensis uncharacterized protein XP_022627519.1 965879 D 1245769 CDS LALA0_S02e10924g 34684705 967191..968162 Unknown 1 NW_019212880.1 highly similar to uniprot|L2FAP4 Colletotrichum gloeosporioides CGGC5_14858 3-carboxymuconate cyclase; uncharacterized protein 968162 34684705 LALA0_S02e10924g Lachancea lanzarotensis uncharacterized protein XP_022627520.1 967191 D 1245769 CDS LALA0_S02e10946g 34684706 968374..969969 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C THP3 Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes; uncharacterized protein 969969 34684706 LALA0_S02e10946g Lachancea lanzarotensis uncharacterized protein XP_022627521.1 968374 D 1245769 CDS LALA0_S02e10968g 34684707 complement(969994..970719) Unknown 1 NW_019212880.1 similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p; ubiquitin-specific protease YUH1 970719 34684707 LALA0_S02e10968g Lachancea lanzarotensis ubiquitin-specific protease YUH1 XP_022627522.1 969994 R 1245769 CDS LALA0_S02e10990g 34684708 972131..972718 Unknown 1 NW_019212880.1 similar to uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP; uncharacterized protein 972718 34684708 LALA0_S02e10990g Lachancea lanzarotensis uncharacterized protein XP_022627523.1 972131 D 1245769 CDS LALA0_S02e11012g 34684709 complement(972834..974423) Unknown 1 NW_019212880.1 similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; uncharacterized protein 974423 34684709 LALA0_S02e11012g Lachancea lanzarotensis uncharacterized protein XP_022627524.1 972834 R 1245769 CDS LALA0_S02e11034g 34684710 974647..975588 Unknown 1 NW_019212880.1 similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; uncharacterized protein 975588 34684710 LALA0_S02e11034g Lachancea lanzarotensis uncharacterized protein XP_022627525.1 974647 D 1245769 CDS LALA0_S02e11056g 34684711 complement(975597..977123) Unknown 1 NW_019212880.1 similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C RKM4 Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein; ribosomal lysine N-methyltransferase 977123 34684711 LALA0_S02e11056g Lachancea lanzarotensis ribosomal lysine N-methyltransferase XP_022627526.1 975597 R 1245769 CDS LALA0_S02e11078g 34684712 977467..979227 Unknown 1 NW_019212880.1 highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop; Hsp90 cochaperone STI1 979227 34684712 LALA0_S02e11078g Lachancea lanzarotensis Hsp90 cochaperone STI1 XP_022627527.1 977467 D 1245769 CDS LALA0_S02e11100g 34684713 complement(979502..981850) Unknown 1 NW_019212880.1 highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates; chaperone ATPase HSP78 981850 34684713 LALA0_S02e11100g Lachancea lanzarotensis chaperone ATPase HSP78 XP_022627528.1 979502 R 1245769 CDS LALA0_S02e11122g 34684714 983839..984681 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03935 Saccharomyces cerevisiae YDR259C (ohnolog of YOR028C) YAP6 Putative basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; uncharacterized protein 984681 34684714 LALA0_S02e11122g Lachancea lanzarotensis uncharacterized protein XP_022627529.1 983839 D 1245769 CDS LALA0_S02e11166g 34684716 985678..986361 Unknown 1 NW_019212880.1 weakly similar to uniprot|P40103 Saccharomyces cerevisiae YER188W Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p; uncharacterized protein 986361 34684716 LALA0_S02e11166g Lachancea lanzarotensis uncharacterized protein XP_022627530.1 985678 D 1245769 CDS LALA0_S02e11188g 34684717 complement(join(986400..988778,988778..989446,989446..990303)) Unknown 1 NW_019212880.1 weakly similar to uniprot|J8TQE5 Saccharomyces cerevisiae YIL080W TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition; 990303 34684717 LALA0_S02e11188g Lachancea lanzarotensis 986400 R 1245769 CDS LALA0_S02e11232g 34684718 992409..993863 Unknown 1 NW_019212880.1 similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; uncharacterized protein 993863 34684718 LALA0_S02e11232g Lachancea lanzarotensis uncharacterized protein XP_022627531.1 992409 D 1245769 CDS LALA0_S02e11254g 34684719 994433..994756 Unknown 1 NW_019212880.1 highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component; ribosomal protein P1 994756 34684719 LALA0_S02e11254g Lachancea lanzarotensis ribosomal protein P1 XP_022627532.1 994433 D 1245769 CDS LALA0_S02e11276g 34684720 complement(join(995191..995789,996081..996084)) Unknown 1 NW_019212880.1 highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082W (ohnolog of YMR142C) RPL13A Proteincomponent of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Bp; not essential for viability; hassimilarity to rat L13 ribosomal protein; 60S ribosomal protein eL13 996084 34684720 LALA0_S02e11276g Lachancea lanzarotensis 60S ribosomal protein eL13 XP_022627533.1 995191 R 1245769 CDS LALA0_S02e11298g 34684721 join(996905..996928,997343..997750) Unknown 1 NW_019212880.1 highly similar to uniprot|P0CX52 Saccharomyces cerevisiae YDL083C (ohnolog of YMR143W) RPS16B Proteincomponent of the small (40S) ribosomal subunit; identicalto Rps16Ap and has similarity to E. coli S9 and rat S16ribosomal proteins; 40S ribosomal protein uS9 997750 34684721 LALA0_S02e11298g Lachancea lanzarotensis 40S ribosomal protein uS9 XP_022627534.1 996905 D 1245769 CDS LALA0_S02e11320g 34684722 998719..999612 Unknown 1 NW_019212880.1 weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene; uncharacterized protein 999612 34684722 LALA0_S02e11320g Lachancea lanzarotensis uncharacterized protein XP_022627535.1 998719 D 1245769 CDS LALA0_S02e11342g 34684723 complement(join(1000121..1001199,1001298..1001544)) Unknown 1 NW_019212880.1 highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; ATP-dependent RNA helicase SUB2 1001544 34684723 LALA0_S02e11342g Lachancea lanzarotensis ATP-dependent RNA helicase SUB2 XP_022627536.1 1000121 R 1245769 CDS LALA0_S02e11364g 34684724 complement(1003011..1004636) Unknown 1 NW_019212880.1 similar to uniprot|Q07500 Saccharomyces cerevisiae YDL085W (ohnolog of YMR145C) NDE2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; uncharacterized protein 1004636 34684724 LALA0_S02e11364g Lachancea lanzarotensis uncharacterized protein XP_022627537.1 1003011 R 1245769 CDS LALA0_S02e11386g 34684725 complement(1005728..1006780) Unknown 1 NW_019212880.1 highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; translation initiation factor eIF3 subunit i 1006780 34684725 LALA0_S02e11386g Lachancea lanzarotensis translation initiation factor eIF3 subunit i XP_022627538.1 1005728 R 1245769 CDS LALA0_S02e11408g 34684726 complement(1007743..1008564) Unknown 1 NW_019212880.1 highly similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene; carboxymethylenebutenolidase 1008564 34684726 LALA0_S02e11408g Lachancea lanzarotensis carboxymethylenebutenolidase XP_022627539.1 1007743 R 1245769 CDS LALA0_S02e11430g 34684727 1008969..1009499 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03083 Saccharomyces cerevisiae YPL034W Putative protein of unknown function; YPL034W is not essential gene; uncharacterized protein 1009499 34684727 LALA0_S02e11430g Lachancea lanzarotensis uncharacterized protein XP_022627540.1 1008969 D 1245769 CDS LALA0_S02e11452g 34684728 join(1009648..1010252,1010435..1011035) Unknown 1 NW_019212880.1 some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W OSW5 Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion; uncharacterized protein 1011035 34684728 LALA0_S02e11452g Lachancea lanzarotensis uncharacterized protein XP_022627541.1 1009648 D 1245769 CDS LALA0_S02e11474g 34684729 1011218..1012051 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum; dolichyl-diphosphooligosaccharide-protein glycotransferase 1012051 34684729 LALA0_S02e11474g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_022627542.1 1011218 D 1245769 CDS LALA0_S02e11496g 34684730 complement(1012106..1012645) Unknown 1 NW_019212880.1 similar to uniprot|P28627 Saccharomyces cerevisiae YMR150C IMP1 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p; endopeptidase catalytic subunit IMP1 1012645 34684730 LALA0_S02e11496g Lachancea lanzarotensis endopeptidase catalytic subunit IMP1 XP_022627543.1 1012106 R 1245769 CDS LALA0_S02e11518g 34684731 1015355..1016206 Unknown 1 NW_019212880.1 similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; uncharacterized protein 1016206 34684731 LALA0_S02e11518g Lachancea lanzarotensis uncharacterized protein XP_022627544.1 1015355 D 1245769 CDS LALA0_S02e11540g 34684732 1016564..1017910 Unknown 1 NW_019212880.1 weakly similar to uniprot|Q05166 Saccharomyces cerevisiae YDL088C (ohnolog of YMR153W) ASM4 Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p; uncharacterized protein 1017910 34684732 LALA0_S02e11540g Lachancea lanzarotensis uncharacterized protein XP_022627545.1 1016564 D 1245769 CDS LALA0_S02e11562g 34684733 complement(1018020..1019777) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W NUR1 Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate; uncharacterized protein 1019777 34684733 LALA0_S02e11562g Lachancea lanzarotensis uncharacterized protein XP_022627546.1 1018020 R 1245769 CDS LALA0_S02e11584g 34684734 complement(1019920..1022025) Unknown 1 NW_019212880.1 weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C RIM13 Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB; uncharacterized protein 1022025 34684734 LALA0_S02e11584g Lachancea lanzarotensis uncharacterized protein XP_022627547.1 1019920 R 1245769 CDS LALA0_S02e11606g 34684735 1022306..1026520 Unknown 1 NW_019212880.1 similar to uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; 1026520 34684735 LALA0_S02e11606g Lachancea lanzarotensis 1022306 D 1245769 CDS LALA0_S03e00100g 34684736 1196..2368 Unknown 1 NW_019212881.1 similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome; ubiquitin domain-containing protein DSK2 2368 34684736 LALA0_S03e00100g Lachancea lanzarotensis ubiquitin domain-containing protein DSK2 XP_022627548.1 1196 D 1245769 CDS LALA0_S03e00122g 34684737 2542..4227 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation; uncharacterized protein 4227 34684737 LALA0_S03e00122g Lachancea lanzarotensis uncharacterized protein XP_022627549.1 2542 D 1245769 CDS LALA0_S03e00144g 34684738 5903..8101 Unknown 1 NW_019212881.1 similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); protein serine/threonine phosphatase 8101 34684738 LALA0_S03e00144g Lachancea lanzarotensis protein serine/threonine phosphatase XP_022627550.1 5903 D 1245769 CDS LALA0_S03e00166g 34684739 8616..10481 Unknown 1 NW_019212881.1 similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W PGM3 Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential; phosphoribomutase PRM15 10481 34684739 LALA0_S03e00166g Lachancea lanzarotensis phosphoribomutase PRM15 XP_022627551.1 8616 D 1245769 CDS LALA0_S03e00188g 34684740 11193..12173 Unknown 1 NW_019212881.1 highly similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C (ohnolog of YPL273W) MHT1 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; S-adenosylmethionine-homocysteine S-methyltransferase SAM4 12173 34684740 LALA0_S03e00188g Lachancea lanzarotensis S-adenosylmethionine-homocysteine S-methyltransferase SAM4 XP_022627552.1 11193 D 1245769 CDS LALA0_S03e00210g 34684741 join(12627..12673,12835..14296) Unknown 1 NW_019212881.1 similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant; uncharacterized protein 14296 34684741 LALA0_S03e00210g Lachancea lanzarotensis uncharacterized protein XP_022627553.1 12627 D 1245769 CDS LALA0_S03e00232g 34684742 complement(14507..16069) Unknown 1 NW_019212881.1 similar to uniprot|Q03263 Saccharomyces cerevisiae YMR279C (ohnolog of YML116W) Putative boron transporterinvolved in boron efflux and resistance; overexpressionmutant but not null mutant displays boron tolerancephenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene;paralog of the efflux pump ATR1; uncharacterized protein 16069 34684742 LALA0_S03e00232g Lachancea lanzarotensis uncharacterized protein XP_022627554.1 14507 R 1245769 CDS LALA0_S03e00254g 34684743 complement(16819..19881) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP; uncharacterized protein 19881 34684743 LALA0_S03e00254g Lachancea lanzarotensis uncharacterized protein XP_022627555.1 16819 R 1245769 CDS LALA0_S03e00276g 34684744 complement(22990..26613) Unknown 1 NW_019212881.1 similar to uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; DNA-binding transcription factor CAT8 26613 34684744 LALA0_S03e00276g Lachancea lanzarotensis DNA-binding transcription factor CAT8 XP_022627556.1 22990 R 1245769 CDS LALA0_S03e00298g 34684745 28003..28767 Unknown 1 NW_019212881.1 weakly similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; N-acetylglucosaminylphosphatidylinositol deacetylase 28767 34684745 LALA0_S03e00298g Lachancea lanzarotensis N-acetylglucosaminylphosphatidylinositol deacetylase XP_022627557.1 28003 D 1245769 CDS LALA0_S03e00320g 34684746 complement(28834..30447) Unknown 1 NW_019212881.1 weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader; uncharacterized protein 30447 34684746 LALA0_S03e00320g Lachancea lanzarotensis uncharacterized protein XP_022627558.1 28834 R 1245769 CDS LALA0_S03e00342g 34684747 complement(30733..32190) Unknown 1 NW_019212881.1 similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA; tRNA A64-2'-O-ribosylphosphate transferase 32190 34684747 LALA0_S03e00342g Lachancea lanzarotensis tRNA A64-2'-O-ribosylphosphate transferase XP_022627559.1 30733 R 1245769 CDS LALA0_S03e00364g 34684748 join(33471..33490,33651..34458) Unknown 1 NW_019212881.1 similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; uncharacterized protein 34458 34684748 LALA0_S03e00364g Lachancea lanzarotensis uncharacterized protein XP_022627560.1 33471 D 1245769 CDS LALA0_S03e00386g 34684749 34793..36517 Unknown 1 NW_019212881.1 similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; alpha-1,2-mannosyltransferase ALG11 36517 34684749 LALA0_S03e00386g Lachancea lanzarotensis alpha-1,2-mannosyltransferase ALG11 XP_022627561.1 34793 D 1245769 CDS LALA0_S03e00408g 34684750 complement(36691..38637) Unknown 1 NW_019212881.1 similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C (ohnolog of YNL047C) SLM1 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; uncharacterized protein 38637 34684750 LALA0_S03e00408g Lachancea lanzarotensis uncharacterized protein XP_022627562.1 36691 R 1245769 CDS LALA0_S03e00430g 34684751 39367..39777 Unknown 1 NW_019212881.1 similar to uniprot|C5DML8 Lachancea thermotolerans KLTH0G09966g hypothetical protein; uncharacterized protein 39777 34684751 LALA0_S03e00430g Lachancea lanzarotensis uncharacterized protein XP_022627563.1 39367 D 1245769 CDS LALA0_S03e00452g 34684752 40273..42267 Unknown 1 NW_019212881.1 similar to uniprot|Q10740 Saccharomyces cerevisiae YNL045W LAP2 Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; bifunctional aminopeptidase/epoxide hydrolase 42267 34684752 LALA0_S03e00452g Lachancea lanzarotensis bifunctional aminopeptidase/epoxide hydrolase XP_022627564.1 40273 D 1245769 CDS LALA0_S03e00474g 34684753 join(42497..42520,42624..43130) Unknown 1 NW_019212881.1 highly similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; uncharacterized protein 43130 34684753 LALA0_S03e00474g Lachancea lanzarotensis uncharacterized protein XP_022627565.1 42497 D 1245769 CDS LALA0_S03e00496g 34684754 43686..44726 Unknown 1 NW_019212881.1 weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury; uncharacterized protein 44726 34684754 LALA0_S03e00496g Lachancea lanzarotensis uncharacterized protein XP_022627566.1 43686 D 1245769 CDS LALA0_S03e00518g 34684755 complement(44779..46284) Unknown 1 NW_019212881.1 similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; Hsp90 cochaperone SHQ1 46284 34684755 LALA0_S03e00518g Lachancea lanzarotensis Hsp90 cochaperone SHQ1 XP_022627567.1 44779 R 1245769 CDS LALA0_S03e00540g 34684756 46522..47781 Unknown 1 NW_019212881.1 highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p; 2-(3-amino-3-carboxypropyl)histidine synthase 47781 34684756 LALA0_S03e00540g Lachancea lanzarotensis 2-(3-amino-3-carboxypropyl)histidine synthase XP_022627568.1 46522 D 1245769 CDS LALA0_S03e00562g 34684757 complement(47820..50264) Unknown 1 NW_019212881.1 similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG6 50264 34684757 LALA0_S03e00562g Lachancea lanzarotensis Golgi transport complex subunit COG6 XP_022627569.1 47820 R 1245769 CDS LALA0_S03e00584g 34684758 complement(50946..52898) Unknown 1 NW_019212881.1 weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; uncharacterized protein 52898 34684758 LALA0_S03e00584g Lachancea lanzarotensis uncharacterized protein XP_022627570.1 50946 R 1245769 CDS LALA0_S03e00606g 34684759 52907..53437 Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 53437 34684759 LALA0_S03e00606g Lachancea lanzarotensis uncharacterized protein XP_022627571.1 52907 D 1245769 CDS LALA0_S03e00628g 34684760 complement(54233..54934) Unknown 1 NW_019212881.1 weakly similar to uniprot|P53174 Saccharomyces cerevisiae YGL053W PRM8 Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; uncharacterized protein 54934 34684760 LALA0_S03e00628g Lachancea lanzarotensis uncharacterized protein XP_022627572.1 54233 R 1245769 CDS LALA0_S03e00650g 34684761 55694..56344 Unknown 1 NW_019212881.1 similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway; carbonate dehydratase NCE103 56344 34684761 LALA0_S03e00650g Lachancea lanzarotensis carbonate dehydratase NCE103 XP_022627573.1 55694 D 1245769 CDS LALA0_S03e00672g 34684762 57094..58947 Unknown 1 NW_019212881.1 weakly similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation; glucan 1,4-alpha-glucosidase 58947 34684762 LALA0_S03e00672g Lachancea lanzarotensis glucan 1,4-alpha-glucosidase XP_022627574.1 57094 D 1245769 CDS LALA0_S03e00694g 34684763 complement(59005..59502) Unknown 1 NW_019212881.1 similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p; uncharacterized protein 59502 34684763 LALA0_S03e00694g Lachancea lanzarotensis uncharacterized protein XP_022627575.1 59005 R 1245769 CDS LALA0_S03e00716g 34684764 60547..61632 Unknown 1 NW_019212881.1 highly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; isocitrate dehydrogenase (NAD(+)) IDH1 61632 34684764 LALA0_S03e00716g Lachancea lanzarotensis isocitrate dehydrogenase (NAD(+)) IDH1 XP_022627576.1 60547 D 1245769 CDS LALA0_S03e00738g 34684765 62091..63590 Unknown 1 NW_019212881.1 similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis; glucose-induced degradation complex subunit FYV10 63590 34684765 LALA0_S03e00738g Lachancea lanzarotensis glucose-induced degradation complex subunit FYV10 XP_022627577.1 62091 D 1245769 CDS LALA0_S03e00760g 34684766 complement(63595..64578) Unknown 1 NW_019212881.1 similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis; 25S rRNA (uracil2634-N3)-methyltransferase 64578 34684766 LALA0_S03e00760g Lachancea lanzarotensis 25S rRNA (uracil2634-N3)-methyltransferase XP_022627578.1 63595 R 1245769 CDS LALA0_S03e00782g 34684767 complement(64905..65372) Unknown 1 NW_019212881.1 some similarities with uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; phosphatidylinositol N-acetylglucosaminyltransferase GPI15 65372 34684767 LALA0_S03e00782g Lachancea lanzarotensis phosphatidylinositol N-acetylglucosaminyltransferase GPI15 XP_022627579.1 64905 R 1245769 CDS LALA0_S03e00804g 34684768 complement(65546..67222) Unknown 1 NW_019212881.1 similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs; transcription factor TFIIIB subunit BDP1 67222 34684768 LALA0_S03e00804g Lachancea lanzarotensis transcription factor TFIIIB subunit BDP1 XP_022627580.1 65546 R 1245769 CDS LALA0_S03e00826g 34684769 complement(67498..68712) Unknown 1 NW_019212881.1 similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; uncharacterized protein 68712 34684769 LALA0_S03e00826g Lachancea lanzarotensis uncharacterized protein XP_022627581.1 67498 R 1245769 CDS LALA0_S03e00848g 34684770 69695..72043 Unknown 1 NW_019212881.1 similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W (ohnolog of YNL020C) PRK1 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; uncharacterized protein 72043 34684770 LALA0_S03e00848g Lachancea lanzarotensis uncharacterized protein XP_022627582.1 69695 D 1245769 CDS LALA0_S03e00870g 34684771 complement(72118..74238) Unknown 1 NW_019212881.1 highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; histone deacetylase HDA1 74238 34684771 LALA0_S03e00870g Lachancea lanzarotensis histone deacetylase HDA1 XP_022627583.1 72118 R 1245769 CDS LALA0_S03e00892g 34684772 74889..76352 Unknown 1 NW_019212881.1 similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis; rRNA (cytosine-C5-)-methyltransferase RCM1 76352 34684772 LALA0_S03e00892g Lachancea lanzarotensis rRNA (cytosine-C5-)-methyltransferase RCM1 XP_022627584.1 74889 D 1245769 CDS LALA0_S03e00914g 34684773 complement(76437..77543) Unknown 1 NW_019212881.1 highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate; homoisocitrate dehydrogenase 77543 34684773 LALA0_S03e00914g Lachancea lanzarotensis homoisocitrate dehydrogenase XP_022627585.1 76437 R 1245769 CDS LALA0_S03e00936g 34684774 79201..82074 Unknown 1 NW_019212881.1 similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C FAP1 Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1; uncharacterized protein 82074 34684774 LALA0_S03e00936g Lachancea lanzarotensis uncharacterized protein XP_022627586.1 79201 D 1245769 CDS LALA0_S03e00958g 34684775 82215..82964 Unknown 1 NW_019212881.1 similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene; uncharacterized protein 82964 34684775 LALA0_S03e00958g Lachancea lanzarotensis uncharacterized protein XP_022627587.1 82215 D 1245769 CDS LALA0_S03e00980g 34684776 complement(83063..83848) Unknown 1 NW_019212881.1 similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS23 83848 34684776 LALA0_S03e00980g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS23 XP_022627588.1 83063 R 1245769 CDS LALA0_S03e01002g 34684777 84468..84686 Unknown 1 NW_019212881.1 highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A KSH1 Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish; uncharacterized protein 84686 34684777 LALA0_S03e01002g Lachancea lanzarotensis uncharacterized protein XP_022627589.1 84468 D 1245769 CDS LALA0_S03e01024g 34684778 complement(84921..87110) Unknown 1 NW_019212881.1 similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C UTP25 Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif; rRNA-binding ribosome biosynthesis protein UTP25 87110 34684778 LALA0_S03e01024g Lachancea lanzarotensis rRNA-binding ribosome biosynthesis protein UTP25 XP_022627590.1 84921 R 1245769 CDS LALA0_S03e01046g 34684779 89209..90645 Unknown 1 NW_019212881.1 similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells; uncharacterized protein 90645 34684779 LALA0_S03e01046g Lachancea lanzarotensis uncharacterized protein XP_022627591.1 89209 D 1245769 CDS LALA0_S03e01068g 34684780 92640..93539 Unknown 1 NW_019212881.1 similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance; cyclin-dependent protein serine/threonine kinase regulator SSN8 93539 34684780 LALA0_S03e01068g Lachancea lanzarotensis cyclin-dependent protein serine/threonine kinase regulator SSN8 XP_022627592.1 92640 D 1245769 CDS LALA0_S03e01090g 34684781 93949..95064 Unknown 1 NW_019212881.1 weakly similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C (ohnolog of YKL008C) LAG1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; uncharacterized protein 95064 34684781 LALA0_S03e01090g Lachancea lanzarotensis uncharacterized protein XP_022627593.1 93949 D 1245769 CDS LALA0_S03e01112g 34684782 complement(95282..96694) Unknown 1 NW_019212881.1 similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 96694 34684782 LALA0_S03e01112g Lachancea lanzarotensis uncharacterized protein XP_022627594.1 95282 R 1245769 CDS LALA0_S03e01134g 34684783 96965..97807 Unknown 1 NW_019212881.1 similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm; uncharacterized protein 97807 34684783 LALA0_S03e01134g Lachancea lanzarotensis uncharacterized protein XP_022627595.1 96965 D 1245769 CDS LALA0_S03e01156g 34684784 complement(97968..98381) Unknown 1 NW_019212881.1 similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C AIM19 Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth; uncharacterized protein 98381 34684784 LALA0_S03e01156g Lachancea lanzarotensis uncharacterized protein XP_022627596.1 97968 R 1245769 CDS LALA0_S03e01178g 34684785 complement(98672..99082) Unknown 1 NW_019212881.1 some similarities with uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; histone H3 99082 34684785 LALA0_S03e01178g Lachancea lanzarotensis histone H3 XP_022627597.1 98672 R 1245769 CDS LALA0_S03e01200g 34684786 99816..100127 Unknown 1 NW_019212881.1 some similarities with uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; histone H4 100127 34684786 LALA0_S03e01200g Lachancea lanzarotensis histone H4 XP_022627598.1 99816 D 1245769 CDS LALA0_S03e01222g 34684787 complement(100460..101938) Unknown 1 NW_019212881.1 similar to uniprot|P40504 Saccharomyces cerevisiae YIL085C (ohnolog of YNL029C) KTR7 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; uncharacterized protein 101938 34684787 LALA0_S03e01222g Lachancea lanzarotensis uncharacterized protein XP_022627599.1 100460 R 1245769 CDS LALA0_S03e01244g 34684788 complement(join(102119..102987,103114..103141)) Unknown 1 NW_019212881.1 similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C SDS3 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes; uncharacterized protein 103141 34684788 LALA0_S03e01244g Lachancea lanzarotensis uncharacterized protein XP_022627600.1 102119 R 1245769 CDS LALA0_S03e01266g 34684789 103301..104560 Unknown 1 NW_019212881.1 similar to uniprot|Q04235 Saccharomyces cerevisiae YML005W TRM12 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase 104560 34684789 LALA0_S03e01266g Lachancea lanzarotensis tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase XP_022627601.1 103301 D 1245769 CDS LALA0_S03e01288g 34684790 104908..106563 Unknown 1 NW_019212881.1 weakly similar to uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; DNA-binding transcription factor CRZ1 106563 34684790 LALA0_S03e01288g Lachancea lanzarotensis DNA-binding transcription factor CRZ1 XP_022627602.1 104908 D 1245769 CDS LALA0_S03e01310g 34684791 106874..108364 Unknown 1 NW_019212881.1 similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85; SAM complex subunit SAM50 108364 34684791 LALA0_S03e01310g Lachancea lanzarotensis SAM complex subunit SAM50 XP_022627603.1 106874 D 1245769 CDS LALA0_S03e01332g 34684792 complement(108430..109464) Unknown 1 NW_019212881.1 similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C CAB2 Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity); phosphopantothenate--cysteine ligase CAB2 109464 34684792 LALA0_S03e01332g Lachancea lanzarotensis phosphopantothenate--cysteine ligase CAB2 XP_022627604.1 108430 R 1245769 CDS LALA0_S03e01376g 34684794 111018..112439 Unknown 1 NW_019212881.1 similar to uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; uncharacterized protein 112439 34684794 LALA0_S03e01376g Lachancea lanzarotensis uncharacterized protein XP_022627605.1 111018 D 1245769 CDS LALA0_S03e01398g 34684795 114058..116394 Unknown 1 NW_019212881.1 similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains; ubiquitin-specific protease UBP1 116394 34684795 LALA0_S03e01398g Lachancea lanzarotensis ubiquitin-specific protease UBP1 XP_022627606.1 114058 D 1245769 CDS LALA0_S03e01420g 34684796 complement(116535..116930) Unknown 1 NW_019212881.1 similar to Lachancea thermotolerans KLTH0G11440g hypothetical protein; uncharacterized protein 116930 34684796 LALA0_S03e01420g Lachancea lanzarotensis uncharacterized protein XP_022627607.1 116535 R 1245769 CDS LALA0_S03e01442g 34684797 117177..117713 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia; ferroxidase 117713 34684797 LALA0_S03e01442g Lachancea lanzarotensis ferroxidase XP_022627608.1 117177 D 1245769 CDS LALA0_S03e01464g 34684798 118086..118316 Unknown 1 NW_019212881.1 similar to uniprot|P01095 Saccharomyces cerevisiae YNL015W PBI2 Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; uncharacterized protein 118316 34684798 LALA0_S03e01464g Lachancea lanzarotensis uncharacterized protein XP_022627609.1 118086 D 1245769 CDS LALA0_S03e01486g 34684799 118769..122005 Unknown 1 NW_019212881.1 highly similar to uniprot|P22855 Saccharomyces cerevisiae YGL156W AMS1 Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; alpha-mannosidase 122005 34684799 LALA0_S03e01486g Lachancea lanzarotensis alpha-mannosidase XP_022627610.1 118769 D 1245769 CDS LALA0_S03e01508g 34684800 122165..123307 Unknown 1 NW_019212881.1 similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis; protein geranylgeranyltransferase type I subunit CDC43 123307 34684800 LALA0_S03e01508g Lachancea lanzarotensis protein geranylgeranyltransferase type I subunit CDC43 XP_022627611.1 122165 D 1245769 CDS LALA0_S03e01530g 34684801 complement(123360..124256) Unknown 1 NW_019212881.1 similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria; uncharacterized protein 124256 34684801 LALA0_S03e01530g Lachancea lanzarotensis uncharacterized protein XP_022627612.1 123360 R 1245769 CDS LALA0_S03e01552g 34684802 complement(124420..125208) Unknown 1 NW_019212881.1 similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine; holo-[acyl-carrier-protein] synthase 125208 34684802 LALA0_S03e01552g Lachancea lanzarotensis holo-[acyl-carrier-protein] synthase XP_022627613.1 124420 R 1245769 CDS LALA0_S03e01574g 34684803 125391..126410 Unknown 1 NW_019212881.1 similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; uncharacterized protein 126410 34684803 LALA0_S03e01574g Lachancea lanzarotensis uncharacterized protein XP_022627614.1 125391 D 1245769 CDS LALA0_S03e01596g 34684804 126607..129828 Unknown 1 NW_019212881.1 similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription; uncharacterized protein 129828 34684804 LALA0_S03e01596g Lachancea lanzarotensis uncharacterized protein XP_022627615.1 126607 D 1245769 CDS LALA0_S03e01618g 34684805 complement(129909..134159) Unknown 1 NW_019212881.1 similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C INO80 ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription; chromatin-remodeling ATPase INO80 134159 34684805 LALA0_S03e01618g Lachancea lanzarotensis chromatin-remodeling ATPase INO80 XP_022627616.1 129909 R 1245769 CDS LALA0_S03e01640g 34684806 complement(136843..138564) Unknown 1 NW_019212881.1 weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; uncharacterized protein 138564 34684806 LALA0_S03e01640g Lachancea lanzarotensis uncharacterized protein XP_022627617.1 136843 R 1245769 CDS LALA0_S03e01662g 34684807 140195..142240 Unknown 1 NW_019212881.1 highly similar to uniprot|P52910 Saccharomyces cerevisiae YLR153C ACS2 Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; acetate--CoA ligase ACS2 142240 34684807 LALA0_S03e01662g Lachancea lanzarotensis acetate--CoA ligase ACS2 XP_022627618.1 140195 D 1245769 CDS LALA0_S03e01684g 34684808 143720..145543 Unknown 1 NW_019212881.1 similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Putative protein of unknown function; YLR152C is not an essential gene; uncharacterized protein 145543 34684808 LALA0_S03e01684g Lachancea lanzarotensis uncharacterized protein XP_022627619.1 143720 D 1245769 CDS LALA0_S03e01706g 34684809 145679..146635 Unknown 1 NW_019212881.1 similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; 8-oxo-dGTP diphosphatase 146635 34684809 LALA0_S03e01706g Lachancea lanzarotensis 8-oxo-dGTP diphosphatase XP_022627620.1 145679 D 1245769 CDS LALA0_S03e01728g 34684810 complement(join(146927..147715,147971..147976)) Unknown 1 NW_019212881.1 similar to uniprot|P39015 Saccharomyces cerevisiae YLR150W STM1 Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; uncharacterized protein 147976 34684810 LALA0_S03e01728g Lachancea lanzarotensis uncharacterized protein XP_022627621.1 146927 R 1245769 CDS LALA0_S03e01750g 34684811 148902..150374 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; uncharacterized protein 150374 34684811 LALA0_S03e01750g Lachancea lanzarotensis uncharacterized protein XP_022627622.1 148902 D 1245769 CDS LALA0_S03e01772g 34684812 151173..153200 Unknown 1 NW_019212881.1 similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; uncharacterized protein 153200 34684812 LALA0_S03e01772g Lachancea lanzarotensis uncharacterized protein XP_022627623.1 151173 D 1245769 CDS LALA0_S03e01794g 34684813 complement(153268..154743) Unknown 1 NW_019212881.1 similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; uncharacterized protein 154743 34684813 LALA0_S03e01794g Lachancea lanzarotensis uncharacterized protein XP_022627624.1 153268 R 1245769 CDS LALA0_S03e01816g 34684814 complement(155236..155829) Unknown 1 NW_019212881.1 similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; uncharacterized protein 155829 34684814 LALA0_S03e01816g Lachancea lanzarotensis uncharacterized protein XP_022627625.1 155236 R 1245769 CDS LALA0_S03e01838g 34684815 complement(156082..158814) Unknown 1 NW_019212881.1 similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis; tethering complex subunit PEP3 158814 34684815 LALA0_S03e01838g Lachancea lanzarotensis tethering complex subunit PEP3 XP_022627626.1 156082 R 1245769 CDS LALA0_S03e01860g 34684816 159008..159316 Unknown 1 NW_019212881.1 highly similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3; mRNA splicing protein SMD3 159316 34684816 LALA0_S03e01860g Lachancea lanzarotensis mRNA splicing protein SMD3 XP_022627627.1 159008 D 1245769 CDS LALA0_S03e01882g 34684817 complement(159976..161052) Unknown 1 NW_019212881.1 similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; uncharacterized protein 161052 34684817 LALA0_S03e01882g Lachancea lanzarotensis uncharacterized protein XP_022627628.1 159976 R 1245769 CDS LALA0_S03e01904g 34684818 162096..164786 Unknown 1 NW_019212881.1 similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC5 164786 34684818 LALA0_S03e01904g Lachancea lanzarotensis exocyst subunit SEC5 XP_022627629.1 162096 D 1245769 CDS LALA0_S03e01926g 34684819 complement(164916..165245) Unknown 1 NW_019212881.1 weakly similar to uniprot|C5DMT9 Lachancea thermotolerans KLTH0G11572g hypothetical protein; uncharacterized protein 165245 34684819 LALA0_S03e01926g Lachancea lanzarotensis uncharacterized protein XP_022627630.1 164916 R 1245769 CDS LALA0_S03e01948g 34684820 complement(165338..166690) Unknown 1 NW_019212881.1 similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA; uncharacterized protein 166690 34684820 LALA0_S03e01948g Lachancea lanzarotensis uncharacterized protein XP_022627631.1 165338 R 1245769 CDS LALA0_S03e01970g 34684821 167763..168665 Unknown 1 NW_019212881.1 similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid; spermine synthase 168665 34684821 LALA0_S03e01970g Lachancea lanzarotensis spermine synthase XP_022627632.1 167763 D 1245769 CDS LALA0_S03e01992g 34684822 complement(168677..169306) Unknown 1 NW_019212881.1 similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P; uncharacterized protein 169306 34684822 LALA0_S03e01992g Lachancea lanzarotensis uncharacterized protein XP_022627633.1 168677 R 1245769 CDS LALA0_S03e02014g 34684823 169810..172128 Unknown 1 NW_019212881.1 similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; endo-1,3(4)-beta-glucanase 172128 34684823 LALA0_S03e02014g Lachancea lanzarotensis endo-1,3(4)-beta-glucanase XP_022627634.1 169810 D 1245769 CDS LALA0_S03e02036g 34684824 join(172550..172580,172654..174722) Unknown 1 NW_019212881.1 similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; uncharacterized protein 174722 34684824 LALA0_S03e02036g Lachancea lanzarotensis uncharacterized protein XP_022627635.1 172550 D 1245769 CDS LALA0_S03e02058g 34684825 complement(174816..175748) Unknown 1 NW_019212881.1 similar to uniprot|C5DL30 Lachancea thermotolerans KLTH0F09526g hypothetical protein; uncharacterized protein 175748 34684825 LALA0_S03e02058g Lachancea lanzarotensis uncharacterized protein XP_022627636.1 174816 R 1245769 CDS LALA0_S03e02080g 34684826 complement(176058..178160) Unknown 1 NW_019212881.1 similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene; diphthine--ammonia ligase 178160 34684826 LALA0_S03e02080g Lachancea lanzarotensis diphthine--ammonia ligase XP_022627637.1 176058 R 1245769 CDS LALA0_S03e02102g 34684827 complement(178506..179933) Unknown 1 NW_019212881.1 similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source; proline dehydrogenase 179933 34684827 LALA0_S03e02102g Lachancea lanzarotensis proline dehydrogenase XP_022627638.1 178506 R 1245769 CDS LALA0_S03e02124g 34684828 complement(180831..182951) Unknown 1 NW_019212881.1 weakly similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery; uncharacterized protein 182951 34684828 LALA0_S03e02124g Lachancea lanzarotensis uncharacterized protein XP_022627639.1 180831 R 1245769 CDS LALA0_S03e02146g 34684829 183191..184651 Unknown 1 NW_019212881.1 some similarities with uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p; uncharacterized protein 184651 34684829 LALA0_S03e02146g Lachancea lanzarotensis uncharacterized protein XP_022627640.1 183191 D 1245769 CDS LALA0_S03e02168g 34684830 complement(184950..185612) Unknown 1 NW_019212881.1 similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W CWC15 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; U2-type spliceosomal complex subunit CWC15 185612 34684830 LALA0_S03e02168g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC15 XP_022627641.1 184950 R 1245769 CDS LALA0_S03e02190g 34684831 186186..186965 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p; uncharacterized protein 186965 34684831 LALA0_S03e02190g Lachancea lanzarotensis uncharacterized protein XP_022627642.1 186186 D 1245769 CDS LALA0_S03e02212g 34684832 complement(187180..188322) Unknown 1 NW_019212881.1 similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD); uncharacterized protein 188322 34684832 LALA0_S03e02212g Lachancea lanzarotensis uncharacterized protein XP_022627643.1 187180 R 1245769 CDS LALA0_S03e02234g 34684833 complement(188540..191023) Unknown 1 NW_019212881.1 similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 191023 34684833 LALA0_S03e02234g Lachancea lanzarotensis uncharacterized protein XP_022627644.1 188540 R 1245769 CDS LALA0_S03e02256g 34684834 complement(join(191248..194157,194299..194322)) Unknown 1 NW_019212881.1 similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W NHA1 Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; uncharacterized protein 194322 34684834 LALA0_S03e02256g Lachancea lanzarotensis uncharacterized protein XP_022627645.1 191248 R 1245769 CDS LALA0_S03e02278g 34684835 complement(194674..198504) Unknown 1 NW_019212881.1 similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; uncharacterized protein 198504 34684835 LALA0_S03e02278g Lachancea lanzarotensis uncharacterized protein XP_022627646.1 194674 R 1245769 CDS LALA0_S03e02300g 34684836 complement(198872..199876) Unknown 1 NW_019212881.1 similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W RKM5 Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species; S-adenosylmethionine-dependent methyltransferase 199876 34684836 LALA0_S03e02300g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022627647.1 198872 R 1245769 CDS LALA0_S03e02322g 34684837 complement(200086..201183) Unknown 1 NW_019212881.1 highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; aspartate-semialdehyde dehydrogenase 201183 34684837 LALA0_S03e02322g Lachancea lanzarotensis aspartate-semialdehyde dehydrogenase XP_022627648.1 200086 R 1245769 CDS LALA0_S03e02344g 34684838 complement(201524..201748) Unknown 1 NW_019212881.1 some similarities with uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14; DNA-directed RNA polymerase I subunit RPA14 201748 34684838 LALA0_S03e02344g Lachancea lanzarotensis DNA-directed RNA polymerase I subunit RPA14 XP_022627649.1 201524 R 1245769 CDS LALA0_S03e02366g 34684839 202757..203245 Unknown 1 NW_019212881.1 highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; peptidylprolyl isomerase CPR1 203245 34684839 LALA0_S03e02366g Lachancea lanzarotensis peptidylprolyl isomerase CPR1 XP_022627650.1 202757 D 1245769 CDS LALA0_S03e02388g 34684840 204205..205398 Unknown 1 NW_019212881.1 similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin; uncharacterized protein 205398 34684840 LALA0_S03e02388g Lachancea lanzarotensis uncharacterized protein XP_022627651.1 204205 D 1245769 CDS LALA0_S03e02410g 34684841 complement(205612..206367) Unknown 1 NW_019212881.1 similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein; uncharacterized protein 206367 34684841 LALA0_S03e02410g Lachancea lanzarotensis uncharacterized protein XP_022627652.1 205612 R 1245769 CDS LALA0_S03e02432g 34684842 209844..210581 Unknown 1 NW_019212881.1 weakly similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C (ohnolog of YLR136C) CTH1 Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; uncharacterized protein 210581 34684842 LALA0_S03e02432g Lachancea lanzarotensis uncharacterized protein XP_022627653.1 209844 D 1245769 CDS LALA0_S03e02454g 34684843 complement(210806..213067) Unknown 1 NW_019212881.1 weakly similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 Protein of unknown function involved in vacuolar protein sorting; uncharacterized protein 213067 34684843 LALA0_S03e02454g Lachancea lanzarotensis uncharacterized protein XP_022627654.1 210806 R 1245769 CDS LALA0_S03e02476g 34684844 complement(213475..222054) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; uncharacterized protein 222054 34684844 LALA0_S03e02476g Lachancea lanzarotensis uncharacterized protein XP_022627655.1 213475 R 1245769 CDS LALA0_S03e02498g 34684845 complement(222274..224157) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; uncharacterized protein 224157 34684845 LALA0_S03e02498g Lachancea lanzarotensis uncharacterized protein XP_022627656.1 222274 R 1245769 CDS LALA0_S03e02520g 34684846 224733..225914 Unknown 1 NW_019212881.1 similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W AIM6 Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene; uncharacterized protein 225914 34684846 LALA0_S03e02520g Lachancea lanzarotensis uncharacterized protein XP_022627657.1 224733 D 1245769 CDS LALA0_S03e02564g 34684848 complement(227064..229607) Unknown 1 NW_019212881.1 similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; ribonuclease P/MRP protein subunit POP1 229607 34684848 LALA0_S03e02564g Lachancea lanzarotensis ribonuclease P/MRP protein subunit POP1 XP_022627658.1 227064 R 1245769 CDS LALA0_S03e02586g 34684849 join(231394..231554,231629..233237) Unknown 1 NW_019212881.1 similar to uniprot|Q05998 Saccharomyces cerevisiae YLR237W THI7 Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia; thiamine transporter THI7 233237 34684849 LALA0_S03e02586g Lachancea lanzarotensis thiamine transporter THI7 XP_022627659.1 231394 D 1245769 CDS LALA0_S03e02608g 34684850 complement(233317..234291) Unknown 1 NW_019212881.1 similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; ubiquinone biosynthesis protein COQ4 234291 34684850 LALA0_S03e02608g Lachancea lanzarotensis ubiquinone biosynthesis protein COQ4 XP_022627660.1 233317 R 1245769 CDS LALA0_S03e02630g 34684851 234459..235475 Unknown 1 NW_019212881.1 similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; uncharacterized protein 235475 34684851 LALA0_S03e02630g Lachancea lanzarotensis uncharacterized protein XP_022627661.1 234459 D 1245769 CDS LALA0_S03e02652g 34684852 complement(235541..236029) Unknown 1 NW_019212881.1 similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body; uncharacterized protein 236029 34684852 LALA0_S03e02652g Lachancea lanzarotensis uncharacterized protein XP_022627662.1 235541 R 1245769 CDS LALA0_S03e02674g 34684853 236191..237570 Unknown 1 NW_019212881.1 similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C (ohnolog of YLR238W) VPS64 Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; uncharacterized protein 237570 34684853 LALA0_S03e02674g Lachancea lanzarotensis uncharacterized protein XP_022627663.1 236191 D 1245769 CDS LALA0_S03e02696g 34684854 complement(237577..238563) Unknown 1 NW_019212881.1 similar to uniprot|Q06005 Saccharomyces cerevisiae YLR239C LIP2 Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups; lipoyl(octanoyl) transferase LIP2 238563 34684854 LALA0_S03e02696g Lachancea lanzarotensis lipoyl(octanoyl) transferase LIP2 XP_022627664.1 237577 R 1245769 CDS LALA0_S03e02718g 34684855 238673..240064 Unknown 1 NW_019212881.1 similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C RKM2 Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; protein-lysine N-methyltransferase 240064 34684855 LALA0_S03e02718g Lachancea lanzarotensis protein-lysine N-methyltransferase XP_022627665.1 238673 D 1245769 CDS LALA0_S03e02740g 34684856 complement(240157..241257) Unknown 1 NW_019212881.1 weakly similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader; uncharacterized protein 241257 34684856 LALA0_S03e02740g Lachancea lanzarotensis uncharacterized protein XP_022627666.1 240157 R 1245769 CDS LALA0_S03e02762g 34684857 241855..242553 Unknown 1 NW_019212881.1 similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C CAB5 Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; uncharacterized protein 242553 34684857 LALA0_S03e02762g Lachancea lanzarotensis uncharacterized protein XP_022627667.1 241855 D 1245769 CDS LALA0_S03e02784g 34684858 complement(242747..244081) Unknown 1 NW_019212881.1 similar to uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; RNA-processing protein REF2 244081 34684858 LALA0_S03e02784g Lachancea lanzarotensis RNA-processing protein REF2 XP_022627668.1 242747 R 1245769 CDS LALA0_S03e02806g 34684859 244594..246591 Unknown 1 NW_019212881.1 similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; ATP-dependent RNA helicase 246591 34684859 LALA0_S03e02806g Lachancea lanzarotensis ATP-dependent RNA helicase XP_022627669.1 244594 D 1245769 CDS LALA0_S03e02828g 34684860 246918..249521 Unknown 1 NW_019212881.1 similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; phosphatidylinositol 3-kinase VPS34 249521 34684860 LALA0_S03e02828g Lachancea lanzarotensis phosphatidylinositol 3-kinase VPS34 XP_022627670.1 246918 D 1245769 CDS LALA0_S03e02850g 34684861 249697..252039 Unknown 1 NW_019212881.1 similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Putative protein of unknown function, may be involved in detoxification; uncharacterized protein 252039 34684861 LALA0_S03e02850g Lachancea lanzarotensis uncharacterized protein XP_022627671.1 249697 D 1245769 CDS LALA0_S03e02872g 34684862 complement(252069..253004) Unknown 1 NW_019212881.1 similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C ARV1 Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p; sterol homeostasis protein ARV1 253004 34684862 LALA0_S03e02872g Lachancea lanzarotensis sterol homeostasis protein ARV1 XP_022627672.1 252069 R 1245769 CDS LALA0_S03e02894g 34684863 253274..254860 Unknown 1 NW_019212881.1 weakly similar to uniprot|P49686 Saccharomyces cerevisiae YDR192C NUP42 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p; FG-nucleoporin NUP42 254860 34684863 LALA0_S03e02894g Lachancea lanzarotensis FG-nucleoporin NUP42 XP_022627673.1 253274 D 1245769 CDS LALA0_S03e02916g 34684864 255231..256046 Unknown 1 NW_019212881.1 highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Putative protein of unknown function; YLR243W is an essential gene; uncharacterized protein 256046 34684864 LALA0_S03e02916g Lachancea lanzarotensis uncharacterized protein XP_022627674.1 255231 D 1245769 CDS LALA0_S03e02938g 34684865 complement(256174..257388) Unknown 1 NW_019212881.1 similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; NAD-dependent histone deacetylase HST4 257388 34684865 LALA0_S03e02938g Lachancea lanzarotensis NAD-dependent histone deacetylase HST4 XP_022627675.1 256174 R 1245769 CDS LALA0_S03e02960g 34684866 257998..259377 Unknown 1 NW_019212881.1 highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family; RuvB family ATP-dependent DNA helicase pontin 259377 34684866 LALA0_S03e02960g Lachancea lanzarotensis RuvB family ATP-dependent DNA helicase pontin XP_022627676.1 257998 D 1245769 CDS LALA0_S03e02982g 34684867 complement(join(259439..261330,261406..261448)) Unknown 1 NW_019212881.1 similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex; syntaxin-binding protein 261448 34684867 LALA0_S03e02982g Lachancea lanzarotensis syntaxin-binding protein XP_022627677.1 259439 R 1245769 CDS LALA0_S03e03004g 34684868 complement(261676..263310) Unknown 1 NW_019212881.1 highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif; chaperonin-containing T-complex subunit CCT6 263310 34684868 LALA0_S03e03004g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT6 XP_022627678.1 261676 R 1245769 CDS LALA0_S03e03026g 34684869 complement(263838..264956) Unknown 1 NW_019212881.1 highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; methionine aminopeptidase MAP1 264956 34684869 LALA0_S03e03026g Lachancea lanzarotensis methionine aminopeptidase MAP1 XP_022627679.1 263838 R 1245769 CDS LALA0_S03e03048g 34684870 complement(265335..265781) Unknown 1 NW_019212881.1 similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm; cytidine deaminase 265781 34684870 LALA0_S03e03048g Lachancea lanzarotensis cytidine deaminase XP_022627680.1 265335 R 1245769 CDS LALA0_S03e03070g 34684871 267027..269228 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04007 Saccharomyces cerevisiae YDR186C Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 269228 34684871 LALA0_S03e03070g Lachancea lanzarotensis uncharacterized protein XP_022627681.1 267027 D 1245769 CDS LALA0_S03e03092g 34684872 269769..270854 Unknown 1 NW_019212881.1 similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase ERF2 270854 34684872 LALA0_S03e03092g Lachancea lanzarotensis palmitoyltransferase ERF2 XP_022627682.1 269769 D 1245769 CDS LALA0_S03e03114g 34684873 271081..271767 Unknown 1 NW_019212881.1 similar to uniprot|Q04006 Saccharomyces cerevisiae YDR185C (ohnolog of YLR168C) UPS3 Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; uncharacterized protein 271767 34684873 LALA0_S03e03114g Lachancea lanzarotensis uncharacterized protein XP_022627683.1 271081 D 1245769 CDS LALA0_S03e03136g 34684874 272268..273182 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q6Q540 Saccharomyces cerevisiae YDR184C ATC1 Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; uncharacterized protein 273182 34684874 LALA0_S03e03136g Lachancea lanzarotensis uncharacterized protein XP_022627684.1 272268 D 1245769 CDS LALA0_S03e03158g 34684875 complement(273485..273937) Unknown 1 NW_019212881.1 highly similar to uniprot|P61864 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; uncharacterized protein 273937 34684875 LALA0_S03e03158g Lachancea lanzarotensis uncharacterized protein XP_022627685.1 273485 R 1245769 CDS LALA0_S03e03180g 34684876 complement(274577..275260) Unknown 1 NW_019212881.1 similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W PLP1 Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators; uncharacterized protein 275260 34684876 LALA0_S03e03180g Lachancea lanzarotensis uncharacterized protein XP_022627686.1 274577 R 1245769 CDS LALA0_S03e03202g 34684877 275408..277855 Unknown 1 NW_019212881.1 similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC10 277855 34684877 LALA0_S03e03202g Lachancea lanzarotensis exocyst subunit SEC10 XP_022627687.1 275408 D 1245769 CDS LALA0_S03e03224g 34684878 complement(277852..279312) Unknown 1 NW_019212881.1 similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution; uncharacterized protein 279312 34684878 LALA0_S03e03224g Lachancea lanzarotensis uncharacterized protein XP_022627688.1 277852 R 1245769 CDS LALA0_S03e03246g 34684879 279679..280833 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181C SAS4 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p; uncharacterized protein 280833 34684879 LALA0_S03e03246g Lachancea lanzarotensis uncharacterized protein XP_022627689.1 279679 D 1245769 CDS LALA0_S03e03268g 34684880 complement(280863..285218) Unknown 1 NW_019212881.1 similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin; cohesin-loading factor complex subunit SCC2 285218 34684880 LALA0_S03e03268g Lachancea lanzarotensis cohesin-loading factor complex subunit SCC2 XP_022627690.1 280863 R 1245769 CDS LALA0_S03e03290g 34684881 285511..286233 Unknown 1 NW_019212881.1 similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5 Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability; uncharacterized protein 286233 34684881 LALA0_S03e03290g Lachancea lanzarotensis uncharacterized protein XP_022627691.1 285511 D 1245769 CDS LALA0_S03e03312g 34684882 complement(286244..287455) Unknown 1 NW_019212881.1 similar to uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Putative protein of unknown function; uncharacterized protein 287455 34684882 LALA0_S03e03312g Lachancea lanzarotensis uncharacterized protein XP_022627692.1 286244 R 1245769 CDS LALA0_S03e03334g 34684883 287632..288114 Unknown 1 NW_019212881.1 similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; uncharacterized protein 288114 34684883 LALA0_S03e03334g Lachancea lanzarotensis uncharacterized protein XP_022627693.1 287632 D 1245769 CDS LALA0_S03e03356g 34684884 complement(288225..288728) Unknown 1 NW_019212881.1 similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W (ohnolog of YLR164W) SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; uncharacterized protein 288728 34684884 LALA0_S03e03356g Lachancea lanzarotensis uncharacterized protein XP_022627694.1 288225 R 1245769 CDS LALA0_S03e03378g 34684885 290166..291542 Unknown 1 NW_019212881.1 highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; mitochondrial processing peptidase 291542 34684885 LALA0_S03e03378g Lachancea lanzarotensis mitochondrial processing peptidase XP_022627695.1 290166 D 1245769 CDS LALA0_S03e03400g 34684886 complement(291619..293571) Unknown 1 NW_019212881.1 similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex; histone acetyltransferase NGG1 293571 34684886 LALA0_S03e03400g Lachancea lanzarotensis histone acetyltransferase NGG1 XP_022627696.1 291619 R 1245769 CDS LALA0_S03e03422g 34684887 294702..295613 Unknown 1 NW_019212881.1 similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS35 295613 34684887 LALA0_S03e03422g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS35 XP_022627697.1 294702 D 1245769 CDS LALA0_S03e03444g 34684888 complement(join(295816..296538,296677..296718)) Unknown 1 NW_019212881.1 highly similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; uncharacterized protein 296718 34684888 LALA0_S03e03444g Lachancea lanzarotensis uncharacterized protein XP_022627698.1 295816 R 1245769 CDS LALA0_S03e03466g 34684889 complement(297328..298920) Unknown 1 NW_019212881.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 298920 34684889 LALA0_S03e03466g Lachancea lanzarotensis uncharacterized protein XP_022627699.1 297328 R 1245769 CDS LALA0_S03e03488g 34684890 300646..301656 Unknown 1 NW_019212881.1 similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes; inositol polyphosphate multikinase 301656 34684890 LALA0_S03e03488g Lachancea lanzarotensis inositol polyphosphate multikinase XP_022627700.1 300646 D 1245769 CDS LALA0_S03e03510g 34684891 complement(301741..303843) Unknown 1 NW_019212881.1 similar to uniprot|P05453 Saccharomyces cerevisiae YDR172W SUP35 Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype; translation termination factor GTPase eRF3 303843 34684891 LALA0_S03e03510g Lachancea lanzarotensis translation termination factor GTPase eRF3 XP_022627701.1 301741 R 1245769 CDS LALA0_S03e03532g 34684892 complement(304231..305283) Unknown 1 NW_019212881.1 similar to uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; heat shock protein HSP42 305283 34684892 LALA0_S03e03532g Lachancea lanzarotensis heat shock protein HSP42 XP_022627702.1 304231 R 1245769 CDS LALA0_S03e03554g 34684893 complement(306329..307678) Unknown 1 NW_019212881.1 highly similar to Lachancea thermotolerans KLTH0F09174g hypothetical protein; uncharacterized protein 307678 34684893 LALA0_S03e03554g Lachancea lanzarotensis uncharacterized protein XP_022627703.1 306329 R 1245769 CDS LALA0_S03e03576g 34684894 310538..315916 Unknown 1 NW_019212881.1 similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles; Arf family guanine nucleotide exchange factor SEC7 315916 34684894 LALA0_S03e03576g Lachancea lanzarotensis Arf family guanine nucleotide exchange factor SEC7 XP_022627704.1 310538 D 1245769 CDS LALA0_S03e03598g 34684895 317389..318519 Unknown 1 NW_019212881.1 highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 318519 34684895 LALA0_S03e03598g Lachancea lanzarotensis bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 XP_022627705.1 317389 D 1245769 CDS LALA0_S03e03620g 34684896 319153..321756 Unknown 1 NW_019212881.1 similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis; uncharacterized protein 321756 34684896 LALA0_S03e03620g Lachancea lanzarotensis uncharacterized protein XP_022627706.1 319153 D 1245769 CDS LALA0_S03e03642g 34684897 322289..324427 Unknown 1 NW_019212881.1 similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export, and NPC biogenesis; required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 324427 34684897 LALA0_S03e03642g Lachancea lanzarotensis uncharacterized protein XP_022627707.1 322289 D 1245769 CDS LALA0_S03e03664g 34684898 complement(324550..325125) Unknown 1 NW_019212881.1 highly similar to uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; 60S ribosomal protein uL6 325125 34684898 LALA0_S03e03664g Lachancea lanzarotensis 60S ribosomal protein uL6 XP_022627708.1 324550 R 1245769 CDS LALA0_S03e03686g 34684899 complement(join(325762..326663,326758..326830)) Unknown 1 NW_019212881.1 similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; uncharacterized protein 326830 34684899 LALA0_S03e03686g Lachancea lanzarotensis uncharacterized protein XP_022627709.1 325762 R 1245769 CDS LALA0_S03e03708g 34684900 complement(327207..329075) Unknown 1 NW_019212881.1 similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate; uncharacterized protein 329075 34684900 LALA0_S03e03708g Lachancea lanzarotensis uncharacterized protein XP_022627710.1 327207 R 1245769 CDS LALA0_S03e03730g 34684901 329353..333534 Unknown 1 NW_019212881.1 similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; tRNA (guanosine(18)-2'-O)-methyltransferase 333534 34684901 LALA0_S03e03730g Lachancea lanzarotensis tRNA (guanosine(18)-2'-O)-methyltransferase XP_022627711.1 329353 D 1245769 CDS LALA0_S03e03752g 34684902 complement(333601..334389) Unknown 1 NW_019212881.1 similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7); exosome non-catalytic core subunit RRP42 334389 34684902 LALA0_S03e03752g Lachancea lanzarotensis exosome non-catalytic core subunit RRP42 XP_022627712.1 333601 R 1245769 CDS LALA0_S03e03774g 34684903 complement(334563..335390) Unknown 1 NW_019212881.1 weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C RRT6 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins; uncharacterized protein 335390 34684903 LALA0_S03e03774g Lachancea lanzarotensis uncharacterized protein XP_022627713.1 334563 R 1245769 CDS LALA0_S03e03796g 34684904 complement(335635..336090) Unknown 1 NW_019212881.1 similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C TMA17 Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion; uncharacterized protein 336090 34684904 LALA0_S03e03796g Lachancea lanzarotensis uncharacterized protein XP_022627714.1 335635 R 1245769 CDS LALA0_S03e03818g 34684905 336432..338486 Unknown 1 NW_019212881.1 similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p; uncharacterized protein 338486 34684905 LALA0_S03e03818g Lachancea lanzarotensis uncharacterized protein XP_022627715.1 336432 D 1245769 CDS LALA0_S03e03840g 34684906 complement(338481..340499) Unknown 1 NW_019212881.1 similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C (ohnolog of YDL109C) ROG1 Protein with putative serine active lipase domain; uncharacterized protein 340499 34684906 LALA0_S03e03840g Lachancea lanzarotensis uncharacterized protein XP_022627716.1 338481 R 1245769 CDS LALA0_S03e03862g 34684907 complement(341140..342381) Unknown 1 NW_019212881.1 similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability; uncharacterized protein 342381 34684907 LALA0_S03e03862g Lachancea lanzarotensis uncharacterized protein XP_022627717.1 341140 R 1245769 CDS LALA0_S03e03884g 34684908 join(342504..342531,342594..343492) Unknown 1 NW_019212881.1 highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; TFIIH complex serine/threonine-protein kinase subunit KIN28 343492 34684908 LALA0_S03e03884g Lachancea lanzarotensis TFIIH complex serine/threonine-protein kinase subunit KIN28 XP_022627718.1 342504 D 1245769 CDS LALA0_S03e03906g 34684909 complement(343521..344747) Unknown 1 NW_019212881.1 similar to uniprot|C5DL30 Lachancea thermotolerans KLTH0F09526g hypothetical protein; uncharacterized protein 344747 34684909 LALA0_S03e03906g Lachancea lanzarotensis uncharacterized protein XP_022627719.1 343521 R 1245769 CDS LALA0_S03e03928g 34684910 345109..346248 Unknown 1 NW_019212881.1 similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; uncharacterized protein 346248 34684910 LALA0_S03e03928g Lachancea lanzarotensis uncharacterized protein XP_022627720.1 345109 D 1245769 CDS LALA0_S03e03950g 34684911 complement(346255..348120) Unknown 1 NW_019212881.1 similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog; uncharacterized protein 348120 34684911 LALA0_S03e03950g Lachancea lanzarotensis uncharacterized protein XP_022627721.1 346255 R 1245769 CDS LALA0_S03e03972g 34684912 348217..350952 Unknown 1 NW_019212881.1 similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W HUL5 Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; ubiquitin-ubiquitin ligase HUL5 350952 34684912 LALA0_S03e03972g Lachancea lanzarotensis ubiquitin-ubiquitin ligase HUL5 XP_022627722.1 348217 D 1245769 CDS LALA0_S03e03994g 34684913 351180..352712 Unknown 1 NW_019212881.1 similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C EAR1 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p; uncharacterized protein 352712 34684913 LALA0_S03e03994g Lachancea lanzarotensis uncharacterized protein XP_022627723.1 351180 D 1245769 CDS LALA0_S03e04016g 34684914 complement(352915..354411) Unknown 1 NW_019212881.1 similar to uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; uncharacterized protein 354411 34684914 LALA0_S03e04016g Lachancea lanzarotensis uncharacterized protein XP_022627724.1 352915 R 1245769 CDS LALA0_S03e04038g 34684915 complement(355995..357506) Unknown 1 NW_019212881.1 similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; uncharacterized protein 357506 34684915 LALA0_S03e04038g Lachancea lanzarotensis uncharacterized protein XP_022627725.1 355995 R 1245769 CDS LALA0_S03e04060g 34684916 358542..360050 Unknown 1 NW_019212881.1 highly similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; uncharacterized protein 360050 34684916 LALA0_S03e04060g Lachancea lanzarotensis uncharacterized protein XP_022627726.1 358542 D 1245769 CDS LALA0_S03e04082g 34684917 360281..362125 Unknown 1 NW_019212881.1 similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain; uncharacterized protein 362125 34684917 LALA0_S03e04082g Lachancea lanzarotensis uncharacterized protein XP_022627727.1 360281 D 1245769 CDS LALA0_S03e04104g 34684918 complement(join(362122..364251,364333..364350)) Unknown 1 NW_019212881.1 similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; mismatch repair ATPase MLH1 364350 34684918 LALA0_S03e04104g Lachancea lanzarotensis mismatch repair ATPase MLH1 XP_022627728.1 362122 R 1245769 CDS LALA0_S03e04126g 34684919 364470..365600 Unknown 1 NW_019212881.1 similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex; Smc5-Smc6 complex subunit NSE4 365600 34684919 LALA0_S03e04126g Lachancea lanzarotensis Smc5-Smc6 complex subunit NSE4 XP_022627729.1 364470 D 1245769 CDS LALA0_S03e04148g 34684920 complement(365614..366816) Unknown 1 NW_019212881.1 similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C QRI7 Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; uncharacterized protein 366816 34684920 LALA0_S03e04148g Lachancea lanzarotensis uncharacterized protein XP_022627730.1 365614 R 1245769 CDS LALA0_S03e04170g 34684921 368118..369167 Unknown 1 NW_019212881.1 similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene; uncharacterized protein 369167 34684921 LALA0_S03e04170g Lachancea lanzarotensis uncharacterized protein XP_022627731.1 368118 D 1245769 CDS LALA0_S03e04192g 34684922 369672..372131 Unknown 1 NW_019212881.1 similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C PAH1 Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets; homologous to mammalian lipin 1; phosphatidate phosphatase PAH1 372131 34684922 LALA0_S03e04192g Lachancea lanzarotensis phosphatidate phosphatase PAH1 XP_022627732.1 369672 D 1245769 CDS LALA0_S03e04214g 34684923 373028..375469 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals; uncharacterized protein 375469 34684923 LALA0_S03e04214g Lachancea lanzarotensis uncharacterized protein XP_022627733.1 373028 D 1245769 CDS LALA0_S03e04236g 34684924 376246..378327 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C INP2 Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene; uncharacterized protein 378327 34684924 LALA0_S03e04236g Lachancea lanzarotensis uncharacterized protein XP_022627734.1 376246 D 1245769 CDS LALA0_S03e04258g 34684925 complement(378370..379788) Unknown 1 NW_019212881.1 similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; UDP-N-acetylglucosamine diphosphorylase 379788 34684925 LALA0_S03e04258g Lachancea lanzarotensis UDP-N-acetylglucosamine diphosphorylase XP_022627735.1 378370 R 1245769 CDS LALA0_S03e04280g 34684926 381846..386690 Unknown 1 NW_019212881.1 similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase; aminophospholipid-translocating P4-type ATPase DNF3 386690 34684926 LALA0_S03e04280g Lachancea lanzarotensis aminophospholipid-translocating P4-type ATPase DNF3 XP_022627736.1 381846 D 1245769 CDS LALA0_S03e04302g 34684927 complement(386971..387696) Unknown 1 NW_019212881.1 similar to uniprot|P48353 Saccharomyces cerevisiae YMR161W HLJ1 Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ; type I HSP40 co-chaperone HLJ1 387696 34684927 LALA0_S03e04302g Lachancea lanzarotensis type I HSP40 co-chaperone HLJ1 XP_022627737.1 386971 R 1245769 CDS LALA0_S03e04324g 34684928 389037..390152 Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 390152 34684928 LALA0_S03e04324g Lachancea lanzarotensis uncharacterized protein XP_022627738.1 389037 D 1245769 CDS LALA0_S03e04346g 34684929 392448..395735 Unknown 1 NW_019212881.1 highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W POL3 Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER); DNA-directed DNA polymerase delta POL3 395735 34684929 LALA0_S03e04346g Lachancea lanzarotensis DNA-directed DNA polymerase delta POL3 XP_022627739.1 392448 D 1245769 CDS LALA0_S03e04368g 34684930 complement(join(395787..397289,397382..397402)) Unknown 1 NW_019212881.1 similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair; serine/threonine protein kinase DUN1 397402 34684930 LALA0_S03e04368g Lachancea lanzarotensis serine/threonine protein kinase DUN1 XP_022627740.1 395787 R 1245769 CDS LALA0_S03e04390g 34684931 complement(397487..399727) Unknown 1 NW_019212881.1 similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; uncharacterized protein 399727 34684931 LALA0_S03e04390g Lachancea lanzarotensis uncharacterized protein XP_022627741.1 397487 R 1245769 CDS LALA0_S03e04412g 34684932 399988..400356 Unknown 1 NW_019212881.1 similar to uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; uncharacterized protein 400356 34684932 LALA0_S03e04412g Lachancea lanzarotensis uncharacterized protein XP_022627742.1 399988 D 1245769 CDS LALA0_S03e04456g 34684934 complement(400784..401836) Unknown 1 NW_019212881.1 highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C GET3 Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; guanine nucleotide exchange factor GET3 401836 34684934 LALA0_S03e04456g Lachancea lanzarotensis guanine nucleotide exchange factor GET3 XP_022627743.1 400784 R 1245769 CDS LALA0_S03e04478g 34684935 402387..403313 Unknown 1 NW_019212881.1 similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W BUG1 Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; uncharacterized protein 403313 34684935 LALA0_S03e04478g Lachancea lanzarotensis uncharacterized protein XP_022627744.1 402387 D 1245769 CDS LALA0_S03e04500g 34684936 complement(403477..403944) Unknown 1 NW_019212881.1 highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS8m 403944 34684936 LALA0_S03e04500g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS8m XP_022627745.1 403477 R 1245769 CDS LALA0_S03e04522g 34684937 404275..404985 Unknown 1 NW_019212881.1 similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C AIM36 Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; uncharacterized protein 404985 34684937 LALA0_S03e04522g Lachancea lanzarotensis uncharacterized protein XP_022627746.1 404275 D 1245769 CDS LALA0_S03e04544g 34684938 complement(405029..405640) Unknown 1 NW_019212881.1 similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome; U4/U6-U5 snRNP complex subunit SNU23 405640 34684938 LALA0_S03e04544g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit SNU23 XP_022627747.1 405029 R 1245769 CDS LALA0_S03e04566g 34684939 405749..406501 Unknown 1 NW_019212881.1 similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily; polynucleotide 3'-phosphatase 406501 34684939 LALA0_S03e04566g Lachancea lanzarotensis polynucleotide 3'-phosphatase XP_022627748.1 405749 D 1245769 CDS LALA0_S03e04588g 34684940 complement(406584..407864) Unknown 1 NW_019212881.1 highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; proteasome regulatory particle lid subunit RPN6 407864 34684940 LALA0_S03e04588g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN6 XP_022627749.1 406584 R 1245769 CDS LALA0_S03e04610g 34684941 409867..412362 Unknown 1 NW_019212881.1 similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 412362 34684941 LALA0_S03e04610g Lachancea lanzarotensis dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 XP_022627750.1 409867 D 1245769 CDS LALA0_S03e04632g 34684942 complement(412468..414420) Unknown 1 NW_019212881.1 similar to uniprot|Q03795 Saccharomyces cerevisiae YMR155W Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; uncharacterized protein 414420 34684942 LALA0_S03e04632g Lachancea lanzarotensis uncharacterized protein XP_022627751.1 412468 R 1245769 CDS LALA0_S03e04654g 34684943 416393..416803 Unknown 1 NW_019212881.1 similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14; RNA-binding signal recognition particle subunit SRP14 416803 34684943 LALA0_S03e04654g Lachancea lanzarotensis RNA-binding signal recognition particle subunit SRP14 XP_022627752.1 416393 D 1245769 CDS LALA0_S03e04676g 34684944 complement(416889..418187) Unknown 1 NW_019212881.1 similar to uniprot|Q12229 Saccharomyces cerevisiae YDL091C UBX3 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 418187 34684944 LALA0_S03e04676g Lachancea lanzarotensis uncharacterized protein XP_022627753.1 416889 R 1245769 CDS LALA0_S03e04698g 34684945 complement(418637..419902) Unknown 1 NW_019212881.1 similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit; protein farnesyltransferase 419902 34684945 LALA0_S03e04698g Lachancea lanzarotensis protein farnesyltransferase XP_022627754.1 418637 R 1245769 CDS LALA0_S03e04720g 34684946 complement(420247..421140) Unknown 1 NW_019212881.1 similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C (ohnolog of YLL046C) SBP1 Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11; uncharacterized protein 421140 34684946 LALA0_S03e04720g Lachancea lanzarotensis uncharacterized protein XP_022627755.1 420247 R 1245769 CDS LALA0_S03e04742g 34684947 424890..429044 Unknown 1 NW_019212881.1 highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p; L-aminoadipate-semialdehyde dehydrogenase 429044 34684947 LALA0_S03e04742g Lachancea lanzarotensis L-aminoadipate-semialdehyde dehydrogenase XP_022627756.1 424890 D 1245769 CDS LALA0_S03e04764g 34684948 complement(429126..431492) Unknown 1 NW_019212881.1 highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; DNA repair protein RAD16 431492 34684948 LALA0_S03e04764g Lachancea lanzarotensis DNA repair protein RAD16 XP_022627757.1 429126 R 1245769 CDS LALA0_S03e04786g 34684949 433959..436583 Unknown 1 NW_019212881.1 similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]; transcription regulator CYC8 436583 34684949 LALA0_S03e04786g Lachancea lanzarotensis transcription regulator CYC8 XP_022627758.1 433959 D 1245769 CDS LALA0_S03e04808g 34684950 complement(join(436652..436731,436813..436952,437115..437194)) Unknown 1 NW_019212881.1 similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; uncharacterized protein 437194 34684950 LALA0_S03e04808g Lachancea lanzarotensis uncharacterized protein XP_022627759.1 436652 R 1245769 CDS LALA0_S03e04830g 34684951 437365..438075 Unknown 1 NW_019212881.1 similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C YSA1 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; ADP-ribose diphosphatase 438075 34684951 LALA0_S03e04830g Lachancea lanzarotensis ADP-ribose diphosphatase XP_022627760.1 437365 D 1245769 CDS LALA0_S03e04852g 34684952 complement(438177..439454) Unknown 1 NW_019212881.1 similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; uncharacterized protein 439454 34684952 LALA0_S03e04852g Lachancea lanzarotensis uncharacterized protein XP_022627761.1 438177 R 1245769 CDS LALA0_S03e04874g 34684953 440809..441693 Unknown 1 NW_019212881.1 highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; spermidine synthase 441693 34684953 LALA0_S03e04874g Lachancea lanzarotensis spermidine synthase XP_022627762.1 440809 D 1245769 CDS LALA0_S03e04896g 34684954 441869..443242 Unknown 1 NW_019212881.1 similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C HOS1 Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex; histone deacetylase 443242 34684954 LALA0_S03e04896g Lachancea lanzarotensis histone deacetylase XP_022627763.1 441869 D 1245769 CDS LALA0_S03e04918g 34684955 complement(443263..444612) Unknown 1 NW_019212881.1 similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase 444612 34684955 LALA0_S03e04918g Lachancea lanzarotensis chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase XP_022627764.1 443263 R 1245769 CDS LALA0_S03e04940g 34684956 444954..445397 Unknown 1 NW_019212881.1 highly similar to uniprot|P06787 Saccharomyces cerevisiae YBR109C CMD1 Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; calmodulin 445397 34684956 LALA0_S03e04940g Lachancea lanzarotensis calmodulin XP_022627765.1 444954 D 1245769 CDS LALA0_S03e04962g 34684957 complement(445686..447845) Unknown 1 NW_019212881.1 weakly similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W AIM3 Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss; uncharacterized protein 447845 34684957 LALA0_S03e04962g Lachancea lanzarotensis uncharacterized protein XP_022627766.1 445686 R 1245769 CDS LALA0_S03e04984g 34684958 449227..449955 Unknown 1 NW_019212881.1 weakly similar to uniprot|P38265 Saccharomyces cerevisiae YBR107C IML3 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p; uncharacterized protein 449955 34684958 LALA0_S03e04984g Lachancea lanzarotensis uncharacterized protein XP_022627767.1 449227 D 1245769 CDS LALA0_S03e05006g 34684959 complement(450055..450681) Unknown 1 NW_019212881.1 similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations; uncharacterized protein 450681 34684959 LALA0_S03e05006g Lachancea lanzarotensis uncharacterized protein XP_022627768.1 450055 R 1245769 CDS LALA0_S03e05028g 34684960 complement(451134..452069) Unknown 1 NW_019212881.1 similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; NEDD8-activating protein UBA3 452069 34684960 LALA0_S03e05028g Lachancea lanzarotensis NEDD8-activating protein UBA3 XP_022627769.1 451134 R 1245769 CDS LALA0_S03e05050g 34684961 complement(452239..452811) Unknown 1 NW_019212881.1 highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; uncharacterized protein 452811 34684961 LALA0_S03e05050g Lachancea lanzarotensis uncharacterized protein XP_022627770.1 452239 R 1245769 CDS LALA0_S03e05072g 34684962 454425..454949 Unknown 1 NW_019212881.1 highly similar to uniprot|Q3E757 Saccharomyces cerevisiae YGR085C (ohnolog of YPR102C) RPL11B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11; 60S ribosomal protein uL5 454949 34684962 LALA0_S03e05072g Lachancea lanzarotensis 60S ribosomal protein uL5 XP_022627771.1 454425 D 1245769 CDS LALA0_S03e05094g 34684963 complement(455063..455638) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06091 Saccharomyces cerevisiae YPR101W SNT309 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p; uncharacterized protein 455638 34684963 LALA0_S03e05094g Lachancea lanzarotensis uncharacterized protein XP_022627772.1 455063 R 1245769 CDS LALA0_S03e05116g 34684964 456094..457044 Unknown 1 NW_019212881.1 similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit; uncharacterized protein 457044 34684964 LALA0_S03e05116g Lachancea lanzarotensis uncharacterized protein XP_022627773.1 456094 D 1245769 CDS LALA0_S03e05138g 34684965 457391..458686 Unknown 1 NW_019212881.1 weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C ART10 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene; uncharacterized protein 458686 34684965 LALA0_S03e05138g Lachancea lanzarotensis uncharacterized protein XP_022627774.1 457391 D 1245769 CDS LALA0_S03e05160g 34684966 459024..460871 Unknown 1 NW_019212881.1 similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B subunit delta 460871 34684966 LALA0_S03e05160g Lachancea lanzarotensis translation initiation factor eIF2B subunit delta XP_022627775.1 459024 D 1245769 CDS LALA0_S03e05182g 34684967 complement(460973..461401) Unknown 1 NW_019212881.1 highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL43 461401 34684967 LALA0_S03e05182g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL43 XP_022627776.1 460973 R 1245769 CDS LALA0_S03e05204g 34684968 join(462745..462791,462860..463298) Unknown 1 NW_019212881.1 similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Protein of unknown function, localized to the mitochondrial outer membrane; uncharacterized protein 463298 34684968 LALA0_S03e05204g Lachancea lanzarotensis uncharacterized protein XP_022627777.1 462745 D 1245769 CDS LALA0_S03e05226g 34684969 complement(463629..464204) Unknown 1 NW_019212881.1 similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; uncharacterized protein 464204 34684969 LALA0_S03e05226g Lachancea lanzarotensis uncharacterized protein XP_022627778.1 463629 R 1245769 CDS LALA0_S03e05248g 34684970 465930..466529 Unknown 1 NW_019212881.1 similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C SLX9 Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant; uncharacterized protein 466529 34684970 LALA0_S03e05248g Lachancea lanzarotensis uncharacterized protein XP_022627779.1 465930 D 1245769 CDS LALA0_S03e05270g 34684971 complement(466563..469550) Unknown 1 NW_019212881.1 similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 469550 34684971 LALA0_S03e05270g Lachancea lanzarotensis uncharacterized protein XP_022627780.1 466563 R 1245769 CDS LALA0_S03e05314g 34684973 470610..473552 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain; Arf family guanine nucleotide exchange factor SYT1 473552 34684973 LALA0_S03e05314g Lachancea lanzarotensis Arf family guanine nucleotide exchange factor SYT1 XP_022627781.1 470610 D 1245769 CDS LALA0_S03e05336g 34684974 complement(473577..473900) Unknown 1 NW_019212881.1 similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance; U2 snRNP complex subunit RDS3 473900 34684974 LALA0_S03e05336g Lachancea lanzarotensis U2 snRNP complex subunit RDS3 XP_022627782.1 473577 R 1245769 CDS LALA0_S03e05358g 34684975 474135..475007 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein; ubiquitin-protein ligase ASR1 475007 34684975 LALA0_S03e05358g Lachancea lanzarotensis ubiquitin-protein ligase ASR1 XP_022627783.1 474135 D 1245769 CDS LALA0_S03e05380g 34684976 complement(475084..476046) Unknown 1 NW_019212881.1 similar to uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly; uncharacterized protein 476046 34684976 LALA0_S03e05380g Lachancea lanzarotensis uncharacterized protein XP_022627784.1 475084 R 1245769 CDS LALA0_S03e05402g 34684977 complement(477087..477788) Unknown 1 NW_019212881.1 similar to uniprot|C5DLC2 Lachancea thermotolerans KLTH0F11792g hypothetical protein; uncharacterized protein 477788 34684977 LALA0_S03e05402g Lachancea lanzarotensis uncharacterized protein XP_022627785.1 477087 R 1245769 CDS LALA0_S03e05424g 34684978 480754..483156 Unknown 1 NW_019212881.1 similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the ER; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; uncharacterized protein 483156 34684978 LALA0_S03e05424g Lachancea lanzarotensis uncharacterized protein XP_022627786.1 480754 D 1245769 CDS LALA0_S03e05446g 34684979 complement(483258..490319) Unknown 1 NW_019212881.1 similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; protein kinase MEC1 490319 34684979 LALA0_S03e05446g Lachancea lanzarotensis protein kinase MEC1 XP_022627787.1 483258 R 1245769 CDS LALA0_S03e05468g 34684980 complement(491209..491523) Unknown 1 NW_019212881.1 similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; cyclin-dependent protein kinase regulatory subunit CKS1 491523 34684980 LALA0_S03e05468g Lachancea lanzarotensis cyclin-dependent protein kinase regulatory subunit CKS1 XP_022627788.1 491209 R 1245769 CDS LALA0_S03e05490g 34684981 493249..495651 Unknown 1 NW_019212881.1 similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; protein arginine N-methyltransferase 495651 34684981 LALA0_S03e05490g Lachancea lanzarotensis protein arginine N-methyltransferase XP_022627789.1 493249 D 1245769 CDS LALA0_S03e05512g 34684982 complement(495767..498142) Unknown 1 NW_019212881.1 similar to uniprot|Q86ZS6 Saccharomyces cerevisiae YPR089W Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p; uncharacterized protein 498142 34684982 LALA0_S03e05512g Lachancea lanzarotensis uncharacterized protein XP_022627790.1 495767 R 1245769 CDS LALA0_S03e05534g 34684983 499741..501516 Unknown 1 NW_019212881.1 similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease; uncharacterized protein 501516 34684983 LALA0_S03e05534g Lachancea lanzarotensis uncharacterized protein XP_022627791.1 499741 D 1245769 CDS LALA0_S03e05556g 34684984 complement(502070..503998) Unknown 1 NW_019212881.1 similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway; uncharacterized protein 503998 34684984 LALA0_S03e05556g Lachancea lanzarotensis uncharacterized protein XP_022627792.1 502070 R 1245769 CDS LALA0_S03e05578g 34684985 504463..506043 Unknown 1 NW_019212881.1 highly similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain; RNA-binding signal recognition particle subunit SRP54 506043 34684985 LALA0_S03e05578g Lachancea lanzarotensis RNA-binding signal recognition particle subunit SRP54 XP_022627793.1 504463 D 1245769 CDS LALA0_S03e05600g 34684986 506267..507577 Unknown 1 NW_019212881.1 weakly similar to uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance; uncharacterized protein 507577 34684986 LALA0_S03e05600g Lachancea lanzarotensis uncharacterized protein XP_022627794.1 506267 D 1245769 CDS LALA0_S03e05622g 34684987 508744..509841 Unknown 1 NW_019212881.1 weakly similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 509841 34684987 LALA0_S03e05622g Lachancea lanzarotensis uncharacterized protein XP_022627795.1 508744 D 1245769 CDS LALA0_S03e05644g 34684988 509993..511252 Unknown 1 NW_019212881.1 similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C ASA1 Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery; uncharacterized protein 511252 34684988 LALA0_S03e05644g Lachancea lanzarotensis uncharacterized protein XP_022627796.1 509993 D 1245769 CDS LALA0_S03e05666g 34684989 complement(511307..512704) Unknown 1 NW_019212881.1 similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Putative protein of unknown function; uncharacterized protein 512704 34684989 LALA0_S03e05666g Lachancea lanzarotensis uncharacterized protein XP_022627797.1 511307 R 1245769 CDS LALA0_S03e05688g 34684990 513818..514810 Unknown 1 NW_019212881.1 weakly similar to uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor; uncharacterized protein 514810 34684990 LALA0_S03e05688g Lachancea lanzarotensis uncharacterized protein XP_022627798.1 513818 D 1245769 CDS LALA0_S03e05710g 34684991 515677..517209 Unknown 1 NW_019212881.1 highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; H(+)-transporting V1 sector ATPase subunit B 517209 34684991 LALA0_S03e05710g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit B XP_022627799.1 515677 D 1245769 CDS LALA0_S03e05732g 34684992 complement(517407..518927) Unknown 1 NW_019212881.1 similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission; uncharacterized protein 518927 34684992 LALA0_S03e05732g Lachancea lanzarotensis uncharacterized protein XP_022627800.1 517407 R 1245769 CDS LALA0_S03e05754g 34684993 519984..521510 Unknown 1 NW_019212881.1 highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 521510 34684993 LALA0_S03e05754g Lachancea lanzarotensis alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 XP_022627801.1 519984 D 1245769 CDS LALA0_S03e05776g 34684994 521943..523136 Unknown 1 NW_019212881.1 similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity; type 2C protein phosphatase PTC4 523136 34684994 LALA0_S03e05776g Lachancea lanzarotensis type 2C protein phosphatase PTC4 XP_022627802.1 521943 D 1245769 CDS LALA0_S03e05798g 34684995 523345..525279 Unknown 1 NW_019212881.1 similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C TFC1 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63; transcription factor TFIIIC subunit TFC1 525279 34684995 LALA0_S03e05798g Lachancea lanzarotensis transcription factor TFIIIC subunit TFC1 XP_022627803.1 523345 D 1245769 CDS LALA0_S03e05820g 34684996 525529..526056 Unknown 1 NW_019212881.1 highly similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region; mitochondrial 54S ribosomal protein bL31m 526056 34684996 LALA0_S03e05820g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL31m XP_022627804.1 525529 D 1245769 CDS LALA0_S03e05842g 34684997 526228..526656 Unknown 1 NW_019212881.1 highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein; U4/U6-U5 snRNP complex subunit DIB1 526656 34684997 LALA0_S03e05842g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit DIB1 XP_022627805.1 526228 D 1245769 CDS LALA0_S03e05864g 34684998 527348..529333 Unknown 1 NW_019212881.1 highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C (ohnolog of YPR081C) GRS1 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; glycine--tRNA ligase 529333 34684998 LALA0_S03e05864g Lachancea lanzarotensis glycine--tRNA ligase XP_022627806.1 527348 D 1245769 CDS LALA0_S03e05886g 34684999 529922..530392 Unknown 1 NW_019212881.1 similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; uncharacterized protein 530392 34684999 LALA0_S03e05886g Lachancea lanzarotensis uncharacterized protein XP_022627807.1 529922 D 1245769 CDS LALA0_S03e05908g 34685000 complement(join(530532..531729,531791..531804)) Unknown 1 NW_019212881.1 some similarities with uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing; uncharacterized protein 531804 34685000 LALA0_S03e05908g Lachancea lanzarotensis uncharacterized protein XP_022627808.1 530532 R 1245769 CDS LALA0_S03e05930g 34685001 complement(532049..533425) Unknown 1 NW_019212881.1 highly similar to uniprot|P02994 Saccharomyces cerevisiae YBR118W (ohnolog of YPR080W) TEF2 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; uncharacterized protein 533425 34685001 LALA0_S03e05930g Lachancea lanzarotensis uncharacterized protein XP_022627809.1 532049 R 1245769 CDS LALA0_S03e05952g 34685002 complement(534421..535461) Unknown 1 NW_019212881.1 similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; uncharacterized protein 535461 34685002 LALA0_S03e05952g Lachancea lanzarotensis uncharacterized protein XP_022627810.1 534421 R 1245769 CDS LALA0_S03e05974g 34685003 535791..536219 Unknown 1 NW_019212881.1 similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated; uncharacterized protein 536219 34685003 LALA0_S03e05974g Lachancea lanzarotensis uncharacterized protein XP_022627811.1 535791 D 1245769 CDS LALA0_S03e06018g 34685005 complement(537129..537908) Unknown 1 NW_019212881.1 similar to uniprot|C5DFF2 Lachancea thermotolerans KLTH0D14608g hypothetical protein; uncharacterized protein 537908 34685005 LALA0_S03e06018g Lachancea lanzarotensis uncharacterized protein XP_022627812.1 537129 R 1245769 CDS LALA0_S03e06040g 34685006 539041..540162 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q6B149 Saccharomyces cerevisiae YPR075C OPY2 Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone; uncharacterized protein 540162 34685006 LALA0_S03e06040g Lachancea lanzarotensis uncharacterized protein XP_022627813.1 539041 D 1245769 CDS LALA0_S03e06062g 34685007 541285..543327 Unknown 1 NW_019212881.1 highly similar to uniprot|P33315 Saccharomyces cerevisiae YBR117C (ohnolog of YPR074C) TKL2 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; transketolase TKL1 543327 34685007 LALA0_S03e06062g Lachancea lanzarotensis transketolase TKL1 XP_022627814.1 541285 D 1245769 CDS LALA0_S03e06084g 34685008 543657..544133 Unknown 1 NW_019212881.1 similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine; tyrosine protein phosphatase LTP1 544133 34685008 LALA0_S03e06084g Lachancea lanzarotensis tyrosine protein phosphatase LTP1 XP_022627815.1 543657 D 1245769 CDS LALA0_S03e06106g 34685009 complement(544280..545899) Unknown 1 NW_019212881.1 similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; CCR4-NOT core subunit NOT5 545899 34685009 LALA0_S03e06106g Lachancea lanzarotensis CCR4-NOT core subunit NOT5 XP_022627816.1 544280 R 1245769 CDS LALA0_S03e06128g 34685010 complement(546382..547341) Unknown 1 NW_019212881.1 similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family; thiamine transporter TPC1 547341 34685010 LALA0_S03e06128g Lachancea lanzarotensis thiamine transporter TPC1 XP_022627817.1 546382 R 1245769 CDS LALA0_S03e06150g 34685011 548365..549036 Unknown 1 NW_019212881.1 similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5); exosome non-catalytic core subunit RRP46 549036 34685011 LALA0_S03e06150g Lachancea lanzarotensis exosome non-catalytic core subunit RRP46 XP_022627818.1 548365 D 1245769 CDS LALA0_S03e06172g 34685012 complement(549150..552458) Unknown 1 NW_019212881.1 highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 Mitochondrial and cytoplasmic valyl-tRNA synthetase; valine--tRNA ligase 552458 34685012 LALA0_S03e06172g Lachancea lanzarotensis valine--tRNA ligase XP_022627819.1 549150 R 1245769 CDS LALA0_S03e06194g 34685013 552952..555633 Unknown 1 NW_019212881.1 similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains; RNA-binding ribosome biosynthesis protein MRD1 555633 34685013 LALA0_S03e06194g Lachancea lanzarotensis RNA-binding ribosome biosynthesis protein MRD1 XP_022627820.1 552952 D 1245769 CDS LALA0_S03e06216g 34685014 complement(join(555699..557175,557245..557255)) Unknown 1 NW_019212881.1 similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; uncharacterized protein 557255 34685014 LALA0_S03e06216g Lachancea lanzarotensis uncharacterized protein XP_022627821.1 555699 R 1245769 CDS LALA0_S03e06238g 34685015 complement(557560..559287) Unknown 1 NW_019212881.1 highly similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W (ohnolog of YPR111W) DBF2 Ser/Thrkinase involved in transcription and stress response;functions as part of a network of genes in exit frommitosis; localization is cell cycle regulated; activatedby Cdc15p during the exit from mitosis; uncharacterized protein 559287 34685015 LALA0_S03e06238g Lachancea lanzarotensis uncharacterized protein XP_022627822.1 557560 R 1245769 CDS LALA0_S03e06260g 34685016 complement(559616..561037) Unknown 1 NW_019212881.1 similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor, component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP31 561037 34685016 LALA0_S03e06260g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP31 XP_022627823.1 559616 R 1245769 CDS LALA0_S03e06282g 34685017 561479..562483 Unknown 1 NW_019212881.1 highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit AC40, common to RNA polymerase I and III; DNA-directed RNA polymerase core subunit RPC40 562483 34685017 LALA0_S03e06282g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPC40 XP_022627824.1 561479 D 1245769 CDS LALA0_S03e06304g 34685018 complement(562569..563501) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q6B2S3 Saccharomyces cerevisiae YPR109W Predicted membrane protein; dipoid deletion strain has high budding index; uncharacterized protein 563501 34685018 LALA0_S03e06304g Lachancea lanzarotensis uncharacterized protein XP_022627825.1 562569 R 1245769 CDS LALA0_S03e06326g 34685019 complement(563812..567525) Unknown 1 NW_019212881.1 similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; rRNA-processing protein UTP22 567525 34685019 LALA0_S03e06326g Lachancea lanzarotensis rRNA-processing protein UTP22 XP_022627826.1 563812 R 1245769 CDS LALA0_S03e06392g 34685021 complement(568679..571201) Unknown 1 NW_019212881.1 similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation; uncharacterized protein 571201 34685021 LALA0_S03e06392g Lachancea lanzarotensis uncharacterized protein XP_022627827.1 568679 R 1245769 CDS LALA0_S03e06436g 34685023 572586..573665 Unknown 1 NW_019212881.1 similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response; uncharacterized protein 573665 34685023 LALA0_S03e06436g Lachancea lanzarotensis uncharacterized protein XP_022627828.1 572586 D 1245769 CDS LALA0_S03e06458g 34685024 complement(573696..575243) Unknown 1 NW_019212881.1 similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; ESCRT-II subunit protein VPS36 575243 34685024 LALA0_S03e06458g Lachancea lanzarotensis ESCRT-II subunit protein VPS36 XP_022627829.1 573696 R 1245769 CDS LALA0_S03e06480g 34685025 complement(575445..577835) Unknown 1 NW_019212881.1 similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins; ATP-binding cassette long-chain fatty acid transporter PXA2 577835 34685025 LALA0_S03e06480g Lachancea lanzarotensis ATP-binding cassette long-chain fatty acid transporter PXA2 XP_022627830.1 575445 R 1245769 CDS LALA0_S03e06502g 34685026 579449..580240 Unknown 1 NW_019212881.1 similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C PUN1 Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress; uncharacterized protein 580240 34685026 LALA0_S03e06502g Lachancea lanzarotensis uncharacterized protein XP_022627831.1 579449 D 1245769 CDS LALA0_S03e06524g 34685027 complement(580502..582532) Unknown 1 NW_019212881.1 similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W (ohnolog of YKL187C) Putative protein of unknown function; YLR413W is not an essential gene; uncharacterized protein 582532 34685027 LALA0_S03e06524g Lachancea lanzarotensis uncharacterized protein XP_022627832.1 580502 R 1245769 CDS LALA0_S03e06546g 34685028 complement(585200..585724) Unknown 1 NW_019212881.1 similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA; uncharacterized protein 585724 34685028 LALA0_S03e06546g Lachancea lanzarotensis uncharacterized protein XP_022627833.1 585200 R 1245769 CDS LALA0_S03e06568g 34685029 586639..588297 Unknown 1 NW_019212881.1 weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate; DNA-binding transcription repressor ASH1 588297 34685029 LALA0_S03e06568g Lachancea lanzarotensis DNA-binding transcription repressor ASH1 XP_022627834.1 586639 D 1245769 CDS LALA0_S03e06590g 34685030 589220..590593 Unknown 1 NW_019212881.1 similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation; ornithine decarboxylase SPE1 590593 34685030 LALA0_S03e06590g Lachancea lanzarotensis ornithine decarboxylase SPE1 XP_022627835.1 589220 D 1245769 CDS LALA0_S03e06612g 34685031 590976..591905 Unknown 1 NW_019212881.1 similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; uncharacterized protein 591905 34685031 LALA0_S03e06612g Lachancea lanzarotensis uncharacterized protein XP_022627836.1 590976 D 1245769 CDS LALA0_S03e06634g 34685032 593625..599780 Unknown 1 NW_019212881.1 highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; tetrafunctional fatty acid synthase subunit FAS1 599780 34685032 LALA0_S03e06634g Lachancea lanzarotensis tetrafunctional fatty acid synthase subunit FAS1 XP_022627837.1 593625 D 1245769 CDS LALA0_S03e06656g 34685033 complement(600104..600910) Unknown 1 NW_019212881.1 similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W BER1 Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene; uncharacterized protein 600910 34685033 LALA0_S03e06656g Lachancea lanzarotensis uncharacterized protein XP_022627838.1 600104 R 1245769 CDS LALA0_S03e06678g 34685034 602374..603654 Unknown 1 NW_019212881.1 highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS1 603654 34685034 LALA0_S03e06678g Lachancea lanzarotensis ribose phosphate diphosphokinase subunit PRS1 XP_022627839.1 602374 D 1245769 CDS LALA0_S03e06700g 34685035 complement(604176..604907) Unknown 1 NW_019212881.1 similar to uniprot|Q06686 Saccharomyces cerevisiae YLR411W CTR3 High-affinity copper transporter of the plasma membrane acts as a trimer gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; high-affinity Cu transporter CTR3 604907 34685035 LALA0_S03e06700g Lachancea lanzarotensis high-affinity Cu transporter CTR3 XP_022627840.1 604176 R 1245769 CDS LALA0_S03e06722g 34685036 complement(605392..608727) Unknown 1 NW_019212881.1 similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol polyphosphate kinase VIP1 608727 34685036 LALA0_S03e06722g Lachancea lanzarotensis inositol polyphosphate kinase VIP1 XP_022627841.1 605392 R 1245769 CDS LALA0_S03e06744g 34685037 610334..613156 Unknown 1 NW_019212881.1 highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; rRNA-processing protein UTP21 613156 34685037 LALA0_S03e06744g Lachancea lanzarotensis rRNA-processing protein UTP21 XP_022627842.1 610334 D 1245769 CDS LALA0_S03e06766g 34685038 complement(613236..616238) Unknown 1 NW_019212881.1 similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p; uncharacterized protein 616238 34685038 LALA0_S03e06766g Lachancea lanzarotensis uncharacterized protein XP_022627843.1 613236 R 1245769 CDS LALA0_S03e06788g 34685039 616936..617268 Unknown 1 NW_019212881.1 similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C BLS1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene; uncharacterized protein 617268 34685039 LALA0_S03e06788g Lachancea lanzarotensis uncharacterized protein XP_022627844.1 616936 D 1245769 CDS LALA0_S03e06810g 34685040 complement(617396..618091) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; uncharacterized protein 618091 34685040 LALA0_S03e06810g Lachancea lanzarotensis uncharacterized protein XP_022627845.1 617396 R 1245769 CDS LALA0_S03e06832g 34685041 complement(618330..619232) Unknown 1 NW_019212881.1 similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Subunit of the RPD3L complex; involved in histone deacetylation; uncharacterized protein 619232 34685041 LALA0_S03e06832g Lachancea lanzarotensis uncharacterized protein XP_022627846.1 618330 R 1245769 CDS LALA0_S03e06854g 34685042 join(620144..620200,620571..620858) Unknown 1 NW_019212881.1 highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W (ohnolog of YLR406C) RPL31A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; 60S ribosomal protein eL31 620858 34685042 LALA0_S03e06854g Lachancea lanzarotensis 60S ribosomal protein eL31 XP_022627847.1 620144 D 1245769 CDS LALA0_S03e06876g 34685043 complement(621779..622825) Unknown 1 NW_019212881.1 similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; tRNA dihydrouridine synthase 622825 34685043 LALA0_S03e06876g Lachancea lanzarotensis tRNA dihydrouridine synthase XP_022627848.1 621779 R 1245769 CDS LALA0_S03e06898g 34685044 complement(623333..625318) Unknown 1 NW_019212881.1 similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; E3 ubiquitin-protein ligase BRE1 625318 34685044 LALA0_S03e06898g Lachancea lanzarotensis E3 ubiquitin-protein ligase BRE1 XP_022627849.1 623333 R 1245769 CDS LALA0_S03e06920g 34685045 626556..629633 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Putative protein of unknown function; YDL073W is not an essential gene; uncharacterized protein 629633 34685045 LALA0_S03e06920g Lachancea lanzarotensis uncharacterized protein XP_022627850.1 626556 D 1245769 CDS LALA0_S03e06942g 34685046 complement(629705..630538) Unknown 1 NW_019212881.1 similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W FLD1 Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy; seipin 630538 34685046 LALA0_S03e06942g Lachancea lanzarotensis seipin XP_022627851.1 629705 R 1245769 CDS LALA0_S03e06964g 34685047 complement(631026..633125) Unknown 1 NW_019212881.1 weakly similar to uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; can form the [ISP+] prion; zinc-coordinating transcription factor SFP1 633125 34685047 LALA0_S03e06964g Lachancea lanzarotensis zinc-coordinating transcription factor SFP1 XP_022627852.1 631026 R 1245769 CDS LALA0_S03e06986g 34685048 635637..637619 Unknown 1 NW_019212881.1 similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; tRNA dihydrouridine synthase DUS3 637619 34685048 LALA0_S03e06986g Lachancea lanzarotensis tRNA dihydrouridine synthase DUS3 XP_022627853.1 635637 D 1245769 CDS LALA0_S03e07008g 34685049 complement(637943..638458) Unknown 1 NW_019212881.1 similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; uncharacterized protein 638458 34685049 LALA0_S03e07008g Lachancea lanzarotensis uncharacterized protein XP_022627854.1 637943 R 1245769 CDS LALA0_S03e07030g 34685050 642159..644066 Unknown 1 NW_019212881.1 similar to uniprot|Q07442 Saccharomyces cerevisiae YDL070W (ohnolog of YLR399C) BDF2 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; chromatin-binding protein BDF1 644066 34685050 LALA0_S03e07030g Lachancea lanzarotensis chromatin-binding protein BDF1 XP_022627855.1 642159 D 1245769 CDS LALA0_S03e07052g 34685051 645326..649141 Unknown 1 NW_019212881.1 similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; SKI complex RNA helicase subunit SKI2 649141 34685051 LALA0_S03e07052g Lachancea lanzarotensis SKI complex RNA helicase subunit SKI2 XP_022627856.1 645326 D 1245769 CDS LALA0_S03e07074g 34685052 complement(649211..649843) Unknown 1 NW_019212881.1 similar to uniprot|C5DFE5 Lachancea thermotolerans KLTH0D14454g hypothetical protein; uncharacterized protein 649843 34685052 LALA0_S03e07074g Lachancea lanzarotensis uncharacterized protein XP_022627857.1 649211 R 1245769 CDS LALA0_S03e07096g 34685053 650011..652338 Unknown 1 NW_019212881.1 highly similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs; AAA family ATPase AFG2 652338 34685053 LALA0_S03e07096g Lachancea lanzarotensis AAA family ATPase AFG2 XP_022627858.1 650011 D 1245769 CDS LALA0_S03e07118g 34685054 652489..654462 Unknown 1 NW_019212881.1 similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole; tethering complex ATP-binding subunit VPS33 654462 34685054 LALA0_S03e07118g Lachancea lanzarotensis tethering complex ATP-binding subunit VPS33 XP_022627859.1 652489 D 1245769 CDS LALA0_S03e07140g 34685055 complement(654768..654950) Unknown 1 NW_019212881.1 similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VIIa 654950 34685055 LALA0_S03e07140g Lachancea lanzarotensis cytochrome c oxidase subunit VIIa XP_022627860.1 654768 R 1245769 CDS LALA0_S03e07162g 34685056 655317..655553 Unknown 1 NW_019212881.1 similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VIII 655553 34685056 LALA0_S03e07162g Lachancea lanzarotensis cytochrome c oxidase subunit VIII XP_022627861.1 655317 D 1245769 CDS LALA0_S03e07184g 34685057 658057..659310 Unknown 1 NW_019212881.1 highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; isocitrate dehydrogenase (NADP(+)) IDP1 659310 34685057 LALA0_S03e07184g Lachancea lanzarotensis isocitrate dehydrogenase (NADP(+)) IDP1 XP_022627862.1 658057 D 1245769 CDS LALA0_S03e07206g 34685058 complement(659505..659708) Unknown 1 NW_019212881.1 similar to uniprot|C5DFJ1 Lachancea thermotolerans KLTH0D15510g hypothetical protein; uncharacterized protein 659708 34685058 LALA0_S03e07206g Lachancea lanzarotensis uncharacterized protein XP_022627863.1 659505 R 1245769 CDS LALA0_S03e07228g 34685059 complement(659859..660722) Unknown 1 NW_019212881.1 similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6; uncharacterized protein 660722 34685059 LALA0_S03e07228g Lachancea lanzarotensis uncharacterized protein XP_022627864.1 659859 R 1245769 CDS LALA0_S03e07250g 34685060 662360..663646 Unknown 1 NW_019212881.1 weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C ART10 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene; uncharacterized protein 663646 34685060 LALA0_S03e07250g Lachancea lanzarotensis uncharacterized protein XP_022627865.1 662360 D 1245769 CDS LALA0_S03e07272g 34685061 complement(663985..664773) Unknown 1 NW_019212881.1 similar to uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall; uncharacterized protein 664773 34685061 LALA0_S03e07272g Lachancea lanzarotensis uncharacterized protein XP_022627866.1 663985 R 1245769 CDS LALA0_S03e07294g 34685062 complement(665844..666737) Unknown 1 NW_019212881.1 similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; uncharacterized protein 666737 34685062 LALA0_S03e07294g Lachancea lanzarotensis uncharacterized protein XP_022627867.1 665844 R 1245769 CDS LALA0_S03e07316g 34685063 666888..668003 Unknown 1 NW_019212881.1 similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 668003 34685063 LALA0_S03e07316g Lachancea lanzarotensis uncharacterized protein XP_022627868.1 666888 D 1245769 CDS LALA0_S03e07338g 34685064 complement(join(669644..670119,670196..670247)) Unknown 1 NW_019212881.1 highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; calcineurin regulatory subunit B 670247 34685064 LALA0_S03e07338g Lachancea lanzarotensis calcineurin regulatory subunit B XP_022627869.1 669644 R 1245769 CDS LALA0_S03e07360g 34685065 complement(670546..672264) Unknown 1 NW_019212881.1 similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p; 2-(3-amino-3-carboxypropyl)histidine synthase 672264 34685065 LALA0_S03e07360g Lachancea lanzarotensis 2-(3-amino-3-carboxypropyl)histidine synthase XP_022627870.1 670546 R 1245769 CDS LALA0_S03e07382g 34685066 672552..673643 Unknown 1 NW_019212881.1 highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate; dihydroorotase 673643 34685066 LALA0_S03e07382g Lachancea lanzarotensis dihydroorotase XP_022627871.1 672552 D 1245769 CDS LALA0_S03e07404g 34685067 complement(join(673777..674125,674199..674701)) Unknown 1 NW_019212881.1 some similarities with uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; proteasome regulatory particle lid subunit RPN13 674701 34685067 LALA0_S03e07404g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN13 XP_022627872.1 673777 R 1245769 CDS LALA0_S03e07426g 34685068 676016..676609 Unknown 1 NW_019212881.1 similar to uniprot|C5DFN1 Lachancea thermotolerans KLTH0D16456g hypothetical protein; uncharacterized protein 676609 34685068 LALA0_S03e07426g Lachancea lanzarotensis uncharacterized protein XP_022627873.1 676016 D 1245769 CDS LALA0_S03e07448g 34685069 676863..682703 Unknown 1 NW_019212881.1 similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein; uncharacterized protein 682703 34685069 LALA0_S03e07448g Lachancea lanzarotensis uncharacterized protein XP_022627874.1 676863 D 1245769 CDS LALA0_S03e07470g 34685070 683166..683540 Unknown 1 NW_019212881.1 similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; acyl carrier protein 683540 34685070 LALA0_S03e07470g Lachancea lanzarotensis acyl carrier protein XP_022627875.1 683166 D 1245769 CDS LALA0_S03e07492g 34685071 683998..685029 Unknown 1 NW_019212881.1 similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis; type 1 protein phosphatase-activating protein SDS22 685029 34685071 LALA0_S03e07492g Lachancea lanzarotensis type 1 protein phosphatase-activating protein SDS22 XP_022627876.1 683998 D 1245769 CDS LALA0_S03e07514g 34685072 685585..686940 Unknown 1 NW_019212881.1 similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase; threonine--tRNA ligase MST1 686940 34685072 LALA0_S03e07514g Lachancea lanzarotensis threonine--tRNA ligase MST1 XP_022627877.1 685585 D 1245769 CDS LALA0_S03e07536g 34685073 complement(686983..688224) Unknown 1 NW_019212881.1 similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells; protein kinase regulatory subunit ATG17 688224 34685073 LALA0_S03e07536g Lachancea lanzarotensis protein kinase regulatory subunit ATG17 XP_022627878.1 686983 R 1245769 CDS LALA0_S03e07558g 34685074 688995..690935 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation; mRNA splicing protein SPP382 690935 34685074 LALA0_S03e07558g Lachancea lanzarotensis mRNA splicing protein SPP382 XP_022627879.1 688995 D 1245769 CDS LALA0_S03e07580g 34685075 complement(691041..691748) Unknown 1 NW_019212881.1 some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins; uncharacterized protein 691748 34685075 LALA0_S03e07580g Lachancea lanzarotensis uncharacterized protein XP_022627880.1 691041 R 1245769 CDS LALA0_S03e07602g 34685076 692931..693533 Unknown 1 NW_019212881.1 highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus; palmitoyltransferase YKT6 693533 34685076 LALA0_S03e07602g Lachancea lanzarotensis palmitoyltransferase YKT6 XP_022627881.1 692931 D 1245769 CDS LALA0_S03e07646g 34685078 694464..698417 Unknown 1 NW_019212881.1 similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate; Rho family guanine nucleotide exchange factor TUS1 698417 34685078 LALA0_S03e07646g Lachancea lanzarotensis Rho family guanine nucleotide exchange factor TUS1 XP_022627882.1 694464 D 1245769 CDS LALA0_S03e07668g 34685079 join(698846..698925,699009..699912) Unknown 1 NW_019212881.1 similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W TDA5 Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; uncharacterized protein 699912 34685079 LALA0_S03e07668g Lachancea lanzarotensis uncharacterized protein XP_022627883.1 698846 D 1245769 CDS LALA0_S03e07690g 34685080 complement(700007..700513) Unknown 1 NW_019212881.1 similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; signal peptidase complex subunit SPC2 700513 34685080 LALA0_S03e07690g Lachancea lanzarotensis signal peptidase complex subunit SPC2 XP_022627884.1 700007 R 1245769 CDS LALA0_S03e07712g 34685081 700803..702701 Unknown 1 NW_019212881.1 similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; uncharacterized protein 702701 34685081 LALA0_S03e07712g Lachancea lanzarotensis uncharacterized protein XP_022627885.1 700803 D 1245769 CDS LALA0_S03e07734g 34685082 join(703063..703067,703156..705187) Unknown 1 NW_019212881.1 similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly; uncharacterized protein 705187 34685082 LALA0_S03e07734g Lachancea lanzarotensis uncharacterized protein XP_022627886.1 703063 D 1245769 CDS LALA0_S03e07756g 34685083 705581..711946 Unknown 1 NW_019212881.1 similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis; DNA/RNA helicase SEN1 711946 34685083 LALA0_S03e07756g Lachancea lanzarotensis DNA/RNA helicase SEN1 XP_022627887.1 705581 D 1245769 CDS LALA0_S03e07778g 34685084 complement(712002..713324) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p; uncharacterized protein 713324 34685084 LALA0_S03e07778g Lachancea lanzarotensis uncharacterized protein XP_022627888.1 712002 R 1245769 CDS LALA0_S03e07800g 34685085 join(715147..715606,715893..717007) Unknown 1 NW_019212881.1 highly similar to uniprot|P50095 Saccharomyces cerevisiae YLR432W (ohnolog of YML056C IMD4) IMD3 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; IMP dehydrogenase IMD3 717007 34685085 LALA0_S03e07800g Lachancea lanzarotensis IMP dehydrogenase IMD3 XP_022627889.1 715147 D 1245769 CDS LALA0_S03e07822g 34685086 complement(717169..718866) Unknown 1 NW_019212881.1 similar to uniprot|P14747 Saccharomyces cerevisiae YML057W (ohnolog of YLR433C) CMP2 Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; calcineurin catalytic subunit A 718866 34685086 LALA0_S03e07822g Lachancea lanzarotensis calcineurin catalytic subunit A XP_022627890.1 717169 R 1245769 CDS LALA0_S03e07844g 34685087 719350..720000 Unknown 1 NW_019212881.1 similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing; uncharacterized protein 720000 34685087 LALA0_S03e07844g Lachancea lanzarotensis uncharacterized protein XP_022627891.1 719350 D 1245769 CDS LALA0_S03e07866g 34685088 complement(720078..723617) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 723617 34685088 LALA0_S03e07866g Lachancea lanzarotensis uncharacterized protein XP_022627892.1 720078 R 1245769 CDS LALA0_S03e07888g 34685089 complement(724211..724627) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04964 Saccharomyces cerevisiae YML058W (ohnolog of YLR437C) SML1 Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; uncharacterized protein 724627 34685089 LALA0_S03e07888g Lachancea lanzarotensis uncharacterized protein XP_022627893.1 724211 R 1245769 CDS LALA0_S03e07910g 34685090 727268..728563 Unknown 1 NW_019212881.1 similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; ornithine-oxo-acid transaminase 728563 34685090 LALA0_S03e07910g Lachancea lanzarotensis ornithine-oxo-acid transaminase XP_022627894.1 727268 D 1245769 CDS LALA0_S03e07932g 34685091 complement(728698..729693) Unknown 1 NW_019212881.1 highly similar to uniprot|P00359 Saccharomyces cerevisiae YGR192C (ohnolog of YJR009C) TDH3 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; uncharacterized protein 729693 34685091 LALA0_S03e07932g Lachancea lanzarotensis uncharacterized protein XP_022627895.1 728698 R 1245769 CDS LALA0_S03e07976g 34685093 732127..736800 Unknown 1 NW_019212881.1 similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes; lysophospholipase 736800 34685093 LALA0_S03e07976g Lachancea lanzarotensis lysophospholipase XP_022627896.1 732127 D 1245769 CDS LALA0_S03e07998g 34685094 complement(737023..737277) Unknown 1 NW_019212881.1 similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; U4/U6-U5 snRNP complex subunit LSM3 737277 34685094 LALA0_S03e07998g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit LSM3 XP_022627897.1 737023 R 1245769 CDS LALA0_S03e08020g 34685095 738002..738958 Unknown 1 NW_019212881.1 similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit; mitochondrial 54S ribosomal protein uL29m 738958 34685095 LALA0_S03e08020g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL29m XP_022627898.1 738002 D 1245769 CDS LALA0_S03e08042g 34685096 complement(739057..740244) Unknown 1 NW_019212881.1 similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance; 8-oxoguanine glycosylase OGG1 740244 34685096 LALA0_S03e08042g Lachancea lanzarotensis 8-oxoguanine glycosylase OGG1 XP_022627899.1 739057 R 1245769 CDS LALA0_S03e08064g 34685097 740619..743213 Unknown 1 NW_019212881.1 similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; DNA helicase PIF1 743213 34685097 LALA0_S03e08064g Lachancea lanzarotensis DNA helicase PIF1 XP_022627900.1 740619 D 1245769 CDS LALA0_S03e08086g 34685098 complement(743332..745401) Unknown 1 NW_019212881.1 similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope; uncharacterized protein 745401 34685098 LALA0_S03e08086g Lachancea lanzarotensis uncharacterized protein XP_022627901.1 743332 R 1245769 CDS LALA0_S03e08108g 34685099 745552..746475 Unknown 1 NW_019212881.1 weakly similar to uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance; uncharacterized protein 746475 34685099 LALA0_S03e08108g Lachancea lanzarotensis uncharacterized protein XP_022627902.1 745552 D 1245769 CDS LALA0_S03e08130g 34685100 complement(746670..747443) Unknown 1 NW_019212881.1 highly similar to uniprot|P23248 Saccharomyces cerevisiae YML063W (ohnolog of YLR441C) RPS1B Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein; 40S ribosomal protein eS1 747443 34685100 LALA0_S03e08130g Lachancea lanzarotensis 40S ribosomal protein eS1 XP_022627903.1 746670 R 1245769 CDS LALA0_S03e08152g 34685101 748369..749040 Unknown 1 NW_019212881.1 similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis; Ras family GTPase TEM1 749040 34685101 LALA0_S03e08152g Lachancea lanzarotensis Ras family GTPase TEM1 XP_022627904.1 748369 D 1245769 CDS LALA0_S03e08174g 34685102 complement(749247..752171) Unknown 1 NW_019212881.1 weakly similar to uniprot|P54784 Saccharomyces cerevisiae YML065W (ohnolog of YLR442C) ORC1 Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity; origin recognition complex subunit 1 752171 34685102 LALA0_S03e08174g Lachancea lanzarotensis origin recognition complex subunit 1 XP_022627905.1 749247 R 1245769 CDS LALA0_S03e08196g 34685103 753999..755204 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency; uncharacterized protein 755204 34685103 LALA0_S03e08196g Lachancea lanzarotensis uncharacterized protein XP_022627906.1 753999 D 1245769 CDS LALA0_S03e08218g 34685104 755333..756520 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; uncharacterized protein 756520 34685104 LALA0_S03e08218g Lachancea lanzarotensis uncharacterized protein XP_022627907.1 755333 D 1245769 CDS LALA0_S03e08240g 34685105 join(756702..756732,756843..757843) Unknown 1 NW_019212881.1 similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; uncharacterized protein 757843 34685105 LALA0_S03e08240g Lachancea lanzarotensis uncharacterized protein XP_022627908.1 756702 D 1245769 CDS LALA0_S03e08262g 34685106 join(757983..758291,758374..758553) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor; uncharacterized protein 758553 34685106 LALA0_S03e08262g Lachancea lanzarotensis uncharacterized protein XP_022627909.1 757983 D 1245769 CDS LALA0_S03e08284g 34685107 complement(758661..760289) Unknown 1 NW_019212881.1 highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; FACT complex subunit POB3 760289 34685107 LALA0_S03e08284g Lachancea lanzarotensis FACT complex subunit POB3 XP_022627910.1 758661 R 1245769 CDS LALA0_S03e08306g 34685108 complement(761397..763154) Unknown 1 NW_019212881.1 highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; dihydroxyacetone kinase 763154 34685108 LALA0_S03e08306g Lachancea lanzarotensis dihydroxyacetone kinase XP_022627911.1 761397 R 1245769 CDS LALA0_S03e08328g 34685109 complement(763877..765226) Unknown 1 NW_019212881.1 weakly similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; uncharacterized protein 765226 34685109 LALA0_S03e08328g Lachancea lanzarotensis uncharacterized protein XP_022627912.1 763877 R 1245769 CDS LALA0_S03e08350g 34685110 complement(765397..767403) Unknown 1 NW_019212881.1 similar to uniprot|C5DFN2 Lachancea thermotolerans KLTH0D16500g hypothetical protein; uncharacterized protein 767403 34685110 LALA0_S03e08350g Lachancea lanzarotensis uncharacterized protein XP_022627913.1 765397 R 1245769 CDS LALA0_S03e08394g 34685112 768833..769342 Unknown 1 NW_019212881.1 similar to uniprot|C5DFN2 Lachancea thermotolerans KLTH0D16500g hypothetical protein; uncharacterized protein 769342 34685112 LALA0_S03e08394g Lachancea lanzarotensis uncharacterized protein XP_022627914.1 768833 D 1245769 CDS LALA0_S03e08416g 34685113 complement(769384..770118) Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 770118 34685113 LALA0_S03e08416g Lachancea lanzarotensis uncharacterized protein XP_022627915.1 769384 R 1245769 CDS LALA0_S03e08438g 34685114 770356..771594 Unknown 1 NW_019212881.1 similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene; hexokinase 771594 34685114 LALA0_S03e08438g Lachancea lanzarotensis hexokinase XP_022627916.1 770356 D 1245769 CDS LALA0_S03e08460g 34685115 complement(772361..772957) Unknown 1 NW_019212881.1 some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; uncharacterized protein 772957 34685115 LALA0_S03e08460g Lachancea lanzarotensis uncharacterized protein XP_022627917.1 772361 R 1245769 CDS LALA0_S03e08482g 34685116 774508..777558 Unknown 1 NW_019212881.1 weakly similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification; uncharacterized protein 777558 34685116 LALA0_S03e08482g Lachancea lanzarotensis uncharacterized protein XP_022627918.1 774508 D 1245769 CDS LALA0_S03e08504g 34685117 complement(777722..778765) Unknown 1 NW_019212881.1 highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane; H(+)-transporting V0 sector ATPase subunit d 778765 34685117 LALA0_S03e08504g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit d XP_022627919.1 777722 R 1245769 CDS LALA0_S03e08526g 34685118 779428..780750 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG8 780750 34685118 LALA0_S03e08526g Lachancea lanzarotensis Golgi transport complex subunit COG8 XP_022627920.1 779428 D 1245769 CDS LALA0_S03e08548g 34685119 781538..786055 Unknown 1 NW_019212881.1 similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact; uncharacterized protein 786055 34685119 LALA0_S03e08548g Lachancea lanzarotensis uncharacterized protein XP_022627921.1 781538 D 1245769 CDS LALA0_S03e08570g 34685120 join(787913..787927,788268..788786) Unknown 1 NW_019212881.1 highly similar to uniprot|Q02326 Saccharomyces cerevisiae YML073C (ohnolog of YLR448W) RPL6A N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA; 60S ribosomal protein eL6 788786 34685120 LALA0_S03e08570g Lachancea lanzarotensis 60S ribosomal protein eL6 XP_022627922.1 787913 D 1245769 CDS LALA0_S03e08592g 34685121 complement(789059..790357) Unknown 1 NW_019212881.1 similar to uniprot|P27466 Saccharomyces cerevisiae YFR014C (ohnolog of YOL016C) CMK1 Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II; uncharacterized protein 790357 34685121 LALA0_S03e08592g Lachancea lanzarotensis uncharacterized protein XP_022627923.1 789059 R 1245769 CDS LALA0_S03e08614g 34685122 complement(791090..793225) Unknown 1 NW_019212881.1 highly similar to uniprot|P23337 Saccharomyces cerevisiae YFR015C (ohnolog of YLR258W) GSY1 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; uncharacterized protein 793225 34685122 LALA0_S03e08614g Lachancea lanzarotensis uncharacterized protein XP_022627924.1 791090 R 1245769 CDS LALA0_S03e08636g 34685123 complement(795177..797672) Unknown 1 NW_019212881.1 similar to uniprot|C5DE00 Lachancea thermotolerans KLTH0C05148g hypothetical protein; uncharacterized protein 797672 34685123 LALA0_S03e08636g Lachancea lanzarotensis uncharacterized protein XP_022627925.1 795177 R 1245769 CDS LALA0_S03e08680g 34685125 complement(799782..801845) Unknown 1 NW_019212881.1 some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene; uncharacterized protein 801845 34685125 LALA0_S03e08680g Lachancea lanzarotensis uncharacterized protein XP_022627926.1 799782 R 1245769 CDS LALA0_S03e08702g 34685126 complement(801876..802781) Unknown 1 NW_019212881.1 similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Putative protein of unknown function; uncharacterized protein 802781 34685126 LALA0_S03e08702g Lachancea lanzarotensis uncharacterized protein XP_022627927.1 801876 R 1245769 CDS LALA0_S03e08746g 34685128 803644..804192 Unknown 1 NW_019212881.1 similar to uniprot|C5DE00 Lachancea thermotolerans KLTH0C05148g hypothetical protein; uncharacterized protein 804192 34685128 LALA0_S03e08746g Lachancea lanzarotensis uncharacterized protein XP_022627928.1 803644 D 1245769 CDS LALA0_S03e08768g 34685129 804535..806145 Unknown 1 NW_019212881.1 similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W AIM14 Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 806145 34685129 LALA0_S03e08768g Lachancea lanzarotensis uncharacterized protein XP_022627929.1 804535 D 1245769 CDS LALA0_S03e08790g 34685130 complement(806713..810492) Unknown 1 NW_019212881.1 similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus; uncharacterized protein 810492 34685130 LALA0_S03e08790g Lachancea lanzarotensis uncharacterized protein XP_022627930.1 806713 R 1245769 CDS LALA0_S03e08812g 34685131 812209..812802 Unknown 1 NW_019212881.1 similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; uncharacterized protein 812802 34685131 LALA0_S03e08812g Lachancea lanzarotensis uncharacterized protein XP_022627931.1 812209 D 1245769 CDS LALA0_S03e08834g 34685132 complement(812848..814533) Unknown 1 NW_019212881.1 similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene; uncharacterized protein 814533 34685132 LALA0_S03e08834g Lachancea lanzarotensis uncharacterized protein XP_022627932.1 812848 R 1245769 CDS LALA0_S03e08856g 34685133 816012..816956 Unknown 1 NW_019212881.1 weakly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; uncharacterized protein 816956 34685133 LALA0_S03e08856g Lachancea lanzarotensis uncharacterized protein XP_022627933.1 816012 D 1245769 CDS LALA0_S03e08878g 34685134 complement(817603..818232) Unknown 1 NW_019212881.1 similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; ethanol metabolism protein 818232 34685134 LALA0_S03e08878g Lachancea lanzarotensis ethanol metabolism protein XP_022627934.1 817603 R 1245769 CDS LALA0_S03e08900g 34685135 818787..819323 Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 819323 34685135 LALA0_S03e08900g Lachancea lanzarotensis uncharacterized protein XP_022627935.1 818787 D 1245769 CDS LALA0_S03e08922g 34685136 820029..824261 Unknown 1 NW_019212881.1 some similarities with Lachancea thermotolerans KLTH0H11682g hypothetical protein; uncharacterized protein 824261 34685136 LALA0_S03e08922g Lachancea lanzarotensis uncharacterized protein XP_022627936.1 820029 D 1245769 CDS LALA0_S03e08944g 34685137 complement(825191..827032) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Putative protein of unknown function; uncharacterized protein 827032 34685137 LALA0_S03e08944g Lachancea lanzarotensis uncharacterized protein XP_022627937.1 825191 R 1245769 CDS LALA0_S03e08966g 34685138 828223..829119 Unknown 1 NW_019212881.1 highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; diphthine synthase 829119 34685138 LALA0_S03e08966g Lachancea lanzarotensis diphthine synthase XP_022627938.1 828223 D 1245769 CDS LALA0_S03e08988g 34685139 829630..830100 Unknown 1 NW_019212881.1 highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex; uncharacterized protein 830100 34685139 LALA0_S03e08988g Lachancea lanzarotensis uncharacterized protein XP_022627939.1 829630 D 1245769 CDS LALA0_S03e09010g 34685140 complement(830230..830613) Unknown 1 NW_019212881.1 weakly similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene; uncharacterized protein 830613 34685140 LALA0_S03e09010g Lachancea lanzarotensis uncharacterized protein XP_022627940.1 830230 R 1245769 CDS LALA0_S03e09054g 34685142 complement(831100..835710) Unknown 1 NW_019212881.1 similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C IRC20 Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci; E3 ubiquitin-protein ligase IRC20 835710 34685142 LALA0_S03e09054g Lachancea lanzarotensis E3 ubiquitin-protein ligase IRC20 XP_022627941.1 831100 R 1245769 CDS LALA0_S03e09076g 34685143 join(838499..838591,838594..838824,838827..838958,838960..839301,839303..839527,839530..839754,839754..839972,839977..840117,840119..840703) Unknown 1 NW_019212881.1 putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate; 840703 34685143 LALA0_S03e09076g Lachancea lanzarotensis 838499 D 1245769 CDS LALA0_S03e09098g 34685144 join(841815..841823,842226..844001) Unknown 1 NW_019212881.1 similar to uniprot|P38622 Saccharomyces cerevisiae YGL158W (ohnolog of YLR248W) RCK1 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; serine/threonine protein kinase RCK2 844001 34685144 LALA0_S03e09098g Lachancea lanzarotensis serine/threonine protein kinase RCK2 XP_022627942.1 841815 D 1245769 CDS LALA0_S03e09120g 34685145 846751..849885 Unknown 1 NW_019212881.1 highly similar to uniprot|P53978 Saccharomyces cerevisiae YNL014W (ohnolog of YLR249W) HEF3 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; translation elongation factor EF-3 849885 34685145 LALA0_S03e09120g Lachancea lanzarotensis translation elongation factor EF-3 XP_022627943.1 846751 D 1245769 CDS LALA0_S03e09142g 34685146 join(850194..850334,850424..852352) Unknown 1 NW_019212881.1 similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W SPO1 Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B; uncharacterized protein 852352 34685146 LALA0_S03e09142g Lachancea lanzarotensis uncharacterized protein XP_022627944.1 850194 D 1245769 CDS LALA0_S03e09164g 34685147 852480..853175 Unknown 1 NW_019212881.1 similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 853175 34685147 LALA0_S03e09164g Lachancea lanzarotensis uncharacterized protein XP_022627945.1 852480 D 1245769 CDS LALA0_S03e09186g 34685148 complement(853247..854620) Unknown 1 NW_019212881.1 similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Putative protein of unknown function; YNL011C is not an essential gene; uncharacterized protein 854620 34685148 LALA0_S03e09186g Lachancea lanzarotensis uncharacterized protein XP_022627946.1 853247 R 1245769 CDS LALA0_S03e09208g 34685149 complement(855049..855546) Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 855546 34685149 LALA0_S03e09208g Lachancea lanzarotensis uncharacterized protein XP_022627947.1 855049 R 1245769 CDS LALA0_S03e09230g 34685150 complement(join(855747..855974,855977..856303,856305..856571,856573..856803,856805..856873,856876..856959,856956..857297,857296..857475)) Unknown 1 NW_019212881.1 putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate; 857475 34685150 LALA0_S03e09230g Lachancea lanzarotensis 855747 R 1245769 CDS LALA0_S03e09252g 34685151 858823..859536 Unknown 1 NW_019212881.1 highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation; uncharacterized protein 859536 34685151 LALA0_S03e09252g Lachancea lanzarotensis uncharacterized protein XP_022627948.1 858823 D 1245769 CDS LALA0_S03e09274g 34685152 860024..861259 Unknown 1 NW_019212881.1 highly similar to uniprot|P53982 Saccharomyces cerevisiae YNL009W (ohnolog of YLR174W) IDP3 Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; isocitrate dehydrogenase (NADP(+)) IDP3 861259 34685152 LALA0_S03e09274g Lachancea lanzarotensis isocitrate dehydrogenase (NADP(+)) IDP3 XP_022627949.1 860024 D 1245769 CDS LALA0_S03e09318g 34685154 complement(join(861838..862125,862196..862207)) Unknown 1 NW_019212881.1 hypothetical protein; uncharacterized protein 862207 34685154 LALA0_S03e09318g Lachancea lanzarotensis uncharacterized protein XP_022627950.1 861838 R 1245769 CDS LALA0_S03e09340g 34685155 join(863090..863149,863217..864404) Unknown 1 NW_019212881.1 similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype; ubiquitin-binding ESCRT-I subunit protein STP22 864404 34685155 LALA0_S03e09340g Lachancea lanzarotensis ubiquitin-binding ESCRT-I subunit protein STP22 XP_022627951.1 863090 D 1245769 CDS LALA0_S03e09362g 34685156 864796..866220 Unknown 1 NW_019212881.1 highly similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; uncharacterized protein 866220 34685156 LALA0_S03e09362g Lachancea lanzarotensis uncharacterized protein XP_022627952.1 864796 D 1245769 CDS LALA0_S03e09384g 34685157 complement(866501..867568) Unknown 1 NW_019212881.1 highly similar to uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins; type II HSP40 co-chaperone SIS1 867568 34685157 LALA0_S03e09384g Lachancea lanzarotensis type II HSP40 co-chaperone SIS1 XP_022627953.1 866501 R 1245769 CDS LALA0_S03e09406g 34685158 868099..869010 Unknown 1 NW_019212881.1 highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; TOR complex subunit LST8 869010 34685158 LALA0_S03e09406g Lachancea lanzarotensis TOR complex subunit LST8 XP_022627954.1 868099 D 1245769 CDS LALA0_S03e09428g 34685159 complement(869315..871888) Unknown 1 NW_019212881.1 weakly similar to uniprot|P48743 Saccharomyces cerevisiae YLR176C RFX1 Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins; uncharacterized protein 871888 34685159 LALA0_S03e09428g Lachancea lanzarotensis uncharacterized protein XP_022627955.1 869315 R 1245769 CDS LALA0_S03e09450g 34685160 873497..874441 Unknown 1 NW_019212881.1 similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C RLP7 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; uncharacterized protein 874441 34685160 LALA0_S03e09450g Lachancea lanzarotensis uncharacterized protein XP_022627956.1 873497 D 1245769 CDS LALA0_S03e09472g 34685161 874764..875858 Unknown 1 NW_019212881.1 highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway; 3-isopropylmalate dehydrogenase 875858 34685161 LALA0_S03e09472g Lachancea lanzarotensis 3-isopropylmalate dehydrogenase XP_022627957.1 874764 D 1245769 CDS LALA0_S03e09494g 34685162 complement(876017..877453) Unknown 1 NW_019212881.1 highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria; cysteine desulfurase 877453 34685162 LALA0_S03e09494g Lachancea lanzarotensis cysteine desulfurase XP_022627958.1 876017 R 1245769 CDS LALA0_S03e09516g 34685163 878415..879239 Unknown 1 NW_019212881.1 similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth; uncharacterized protein 879239 34685163 LALA0_S03e09516g Lachancea lanzarotensis uncharacterized protein XP_022627959.1 878415 D 1245769 CDS LALA0_S03e09538g 34685164 complement(879311..880438) Unknown 1 NW_019212881.1 similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance; uncharacterized protein 880438 34685164 LALA0_S03e09538g Lachancea lanzarotensis uncharacterized protein XP_022627960.1 879311 R 1245769 CDS LALA0_S03e09560g 34685165 881628..886091 Unknown 1 NW_019212881.1 similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; uncharacterized protein 886091 34685165 LALA0_S03e09560g Lachancea lanzarotensis uncharacterized protein XP_022627961.1 881628 D 1245769 CDS LALA0_S03e09582g 34685166 complement(join(886153..886460,886518..886602)) Unknown 1 NW_019212881.1 similar to uniprot|Q8J0M4 Saccharomyces cerevisiae YCL012C Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene; uncharacterized protein 886602 34685166 LALA0_S03e09582g Lachancea lanzarotensis uncharacterized protein XP_022627962.1 886153 R 1245769 CDS LALA0_S03e09604g 34685167 complement(join(886953..888152,888357..888371)) Unknown 1 NW_019212881.1 similar to uniprot|P25555 Saccharomyces cerevisiae YCL011C (ohnolog of YNL004W) GBP2 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro; single-stranded telomeric DNA-binding/mRNA-binding protein 888371 34685167 LALA0_S03e09604g Lachancea lanzarotensis single-stranded telomeric DNA-binding/mRNA-binding protein XP_022627963.1 886953 R 1245769 CDS LALA0_S03e09626g 34685168 complement(888826..889557) Unknown 1 NW_019212881.1 similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA recruitment to target promoters and H3 acetylation; uncharacterized protein 889557 34685168 LALA0_S03e09626g Lachancea lanzarotensis uncharacterized protein XP_022627964.1 888826 R 1245769 CDS LALA0_S03e09648g 34685169 889736..890857 Unknown 1 NW_019212881.1 similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL27m 890857 34685169 LALA0_S03e09648g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL27m XP_022627965.1 889736 D 1245769 CDS LALA0_S03e09670g 34685170 complement(890992..891897) Unknown 1 NW_019212881.1 highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria; acetolactate synthase regulatory subunit 891897 34685170 LALA0_S03e09670g Lachancea lanzarotensis acetolactate synthase regulatory subunit XP_022627966.1 890992 R 1245769 CDS LALA0_S03e09692g 34685171 893413..894312 Unknown 1 NW_019212881.1 weakly similar to uniprot|P25587 Saccharomyces cerevisiae YCL005W LDB16 Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria; uncharacterized protein 894312 34685171 LALA0_S03e09692g Lachancea lanzarotensis uncharacterized protein XP_022627967.1 893413 D 1245769 CDS LALA0_S03e09736g 34685173 894698..896254 Unknown 1 NW_019212881.1 similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 896254 34685173 LALA0_S03e09736g Lachancea lanzarotensis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase XP_022627968.1 894698 D 1245769 CDS LALA0_S03e09758g 34685174 complement(join(896325..897080,897134..897169)) Unknown 1 NW_019212881.1 similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C Putative protein of unknown function; YCL002C is not an essential gene; uncharacterized protein 897169 34685174 LALA0_S03e09758g Lachancea lanzarotensis uncharacterized protein XP_022627969.1 896325 R 1245769 CDS LALA0_S03e09780g 34685175 897311..897853 Unknown 1 NW_019212881.1 similar to uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER; protein retrieval receptor 897853 34685175 LALA0_S03e09780g Lachancea lanzarotensis protein retrieval receptor XP_022627970.1 897311 D 1245769 CDS LALA0_S03e09802g 34685176 898149..899312 Unknown 1 NW_019212881.1 similar to uniprot|Q96VH2 Saccharomyces cerevisiae YCL001W-B (ohnolog of YNL001W) Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III; uncharacterized protein 899312 34685176 LALA0_S03e09802g Lachancea lanzarotensis uncharacterized protein XP_022627971.1 898149 D 1245769 CDS LALA0_S03e09846g 34685177 complement(900075..901073) Unknown 1 NW_019212881.1 highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring that is required for cytokinesis; septins recruit proteins to the mother-bud neck and can act as a barrier to diffusion at the membrane, and they comprise the 10 nm filaments seen with EM; required for the transition from a single to double septin ring; septin CDC10 901073 34685177 LALA0_S03e09846g Lachancea lanzarotensis septin CDC10 XP_022627972.1 900075 R 1245769 CDS LALA0_S03e09868g 34685178 901314..901844 Unknown 1 NW_019212881.1 similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL32m 901844 34685178 LALA0_S03e09868g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL32m XP_022627973.1 901314 D 1245769 CDS LALA0_S03e09890g 34685179 902139..903833 Unknown 1 NW_019212881.1 similar to uniprot|C5E3E2 Lachancea thermotolerans KLTH0H12672g hypothetical protein; uncharacterized protein 903833 34685179 LALA0_S03e09890g Lachancea lanzarotensis uncharacterized protein XP_022627974.1 902139 D 1245769 CDS LALA0_S03e09912g 34685180 complement(903967..904710) Unknown 1 NW_019212881.1 highly similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; flavodoxin-like fold family protein 904710 34685180 LALA0_S03e09912g Lachancea lanzarotensis flavodoxin-like fold family protein XP_022627975.1 903967 R 1245769 CDS LALA0_S03e09934g 34685181 complement(905205..906629) Unknown 1 NW_019212881.1 highly similar to uniprot|P08679 Saccharomyces cerevisiae YCR005C (ohnolog of YNR001C) CIT2 Citratesynthase, catalyzes the condensation of acetyl coenzyme Aand oxaloacetate to form citrate, peroxisomal isozymeinvolved in glyoxylate cycle; expression is controlled byRtg1p and Rtg2p transcription factors; citrate (Si)-synthase CIT2 906629 34685181 LALA0_S03e09934g Lachancea lanzarotensis citrate (Si)-synthase CIT2 XP_022627976.1 905205 R 1245769 CDS LALA0_S03e09978g 34685183 908470..910086 Unknown 1 NW_019212881.1 similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W SAT4 Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p; serine/threonine protein kinase SAT4 910086 34685183 LALA0_S03e09978g Lachancea lanzarotensis serine/threonine protein kinase SAT4 XP_022627977.1 908470 D 1245769 CDS LALA0_S03e10000g 34685184 complement(910379..913984) Unknown 1 NW_019212881.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 913984 34685184 LALA0_S03e10000g Lachancea lanzarotensis uncharacterized protein XP_022627978.1 910379 R 1245769 CDS LALA0_S03e10044g 34685186 complement(915734..916531) Unknown 1 NW_019212881.1 highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress; amphiphysin-like protein RVS161 916531 34685186 LALA0_S03e10044g Lachancea lanzarotensis amphiphysin-like protein RVS161 XP_022627979.1 915734 R 1245769 CDS LALA0_S03e10066g 34685187 complement(917367..918299) Unknown 1 NW_019212881.1 highly similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; DNA-directed RNA polymerase III subunit C34 918299 34685187 LALA0_S03e10066g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit C34 XP_022627980.1 917367 R 1245769 CDS LALA0_S03e10088g 34685188 complement(918475..921552) Unknown 1 NW_019212881.1 similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Putative ATP-dependent permease of the ABC transporter family of proteins; uncharacterized protein 921552 34685188 LALA0_S03e10088g Lachancea lanzarotensis uncharacterized protein XP_022627981.1 918475 R 1245769 CDS LALA0_S03e10110g 34685189 complement(922026..923024) Unknown 1 NW_019212881.1 similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Putative protein of unknown function; uncharacterized protein 923024 34685189 LALA0_S03e10110g Lachancea lanzarotensis uncharacterized protein XP_022627982.1 922026 R 1245769 CDS LALA0_S03e10132g 34685190 923132..929575 Unknown 1 NW_019212881.1 similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis; 1-phosphatidylinositol-3-phosphate 5-kinase 929575 34685190 LALA0_S03e10132g Lachancea lanzarotensis 1-phosphatidylinositol-3-phosphate 5-kinase XP_022627983.1 923132 D 1245769 CDS LALA0_S03e10176g 34685192 complement(join(932469..932910,932968..933044)) Unknown 1 NW_019212881.1 similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR); flavin-linked sulfhydryl oxidase 933044 34685192 LALA0_S03e10176g Lachancea lanzarotensis flavin-linked sulfhydryl oxidase XP_022627984.1 932469 R 1245769 CDS LALA0_S03e10198g 34685193 933353..934948 Unknown 1 NW_019212881.1 similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; phosphoinositide binding protein ATG18 934948 34685193 LALA0_S03e10198g Lachancea lanzarotensis phosphoinositide binding protein ATG18 XP_022627985.1 933353 D 1245769 CDS LALA0_S03e10220g 34685194 935449..937722 Unknown 1 NW_019212881.1 similar to uniprot|P43602 Saccharomyces cerevisiae YFR022W (ohnolog of YOR018W) ROG3 Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; uncharacterized protein 937722 34685194 LALA0_S03e10220g Lachancea lanzarotensis uncharacterized protein XP_022627986.1 935449 D 1245769 CDS LALA0_S03e10242g 34685195 938652..940697 Unknown 1 NW_019212881.1 weakly similar to uniprot|Q07500 Saccharomyces cerevisiae YDL085W (ohnolog of YMR145C) NDE2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; uncharacterized protein 940697 34685195 LALA0_S03e10242g Lachancea lanzarotensis uncharacterized protein XP_022627987.1 938652 D 1245769 CDS LALA0_S03e10264g 34685196 941171..943066 Unknown 1 NW_019212881.1 similar to uniprot|P38760 Saccharomyces cerevisiae YHR015W (ohnolog of YFR023W) MIP6 Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; uncharacterized protein 943066 34685196 LALA0_S03e10264g Lachancea lanzarotensis uncharacterized protein XP_022627988.1 941171 D 1245769 CDS LALA0_S03e10286g 34685197 complement(join(943267..944455,944599..944645)) Unknown 1 NW_019212881.1 similar to uniprot|P32793 Saccharomyces cerevisiae YHR016C (ohnolog of YFR024C-A) YSC84 Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; uncharacterized protein 944645 34685197 LALA0_S03e10286g Lachancea lanzarotensis uncharacterized protein XP_022627989.1 943267 R 1245769 CDS LALA0_S03e10308g 34685198 945620..947614 Unknown 1 NW_019212881.1 putative transposase of the Rover hAT-like DNA transposon 947614 34685198 LALA0_S03e10308g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022627990.1 945620 D 1245769 CDS LALA0_S03e10330g 34685199 948664..949695 Unknown 1 NW_019212881.1 weakly similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W YSC83 Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83; uncharacterized protein 949695 34685199 LALA0_S03e10330g Lachancea lanzarotensis uncharacterized protein XP_022627991.1 948664 D 1245769 CDS LALA0_S03e10352g 34685200 complement(949924..951588) Unknown 1 NW_019212881.1 highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; asparagine--tRNA ligase DED81 951588 34685200 LALA0_S03e10352g Lachancea lanzarotensis asparagine--tRNA ligase DED81 XP_022627992.1 949924 R 1245769 CDS LALA0_S03e10374g 34685201 951925..953955 Unknown 1 NW_019212881.1 highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene; proline--tRNA ligase 953955 34685201 LALA0_S03e10374g Lachancea lanzarotensis proline--tRNA ligase XP_022627993.1 951925 D 1245769 CDS LALA0_S03e10396g 34685202 complement(954045..955034) Unknown 1 NW_019212881.1 similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; histidinol-phosphatase 955034 34685202 LALA0_S03e10396g Lachancea lanzarotensis histidinol-phosphatase XP_022627994.1 954045 R 1245769 CDS LALA0_S04e00100g 34685203 812..1072 Unknown 1 NW_019212882.1 similar to uniprot|P16965 Saccharomyces cerevisiae YGR008C (ohnolog of YLR327C) STF2 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein; uncharacterized protein 1072 34685203 LALA0_S04e00100g Lachancea lanzarotensis uncharacterized protein XP_022627995.1 812 D 1245769 CDS LALA0_S04e00122g 34685204 complement(2288..3253) Unknown 1 NW_019212882.1 similar to uniprot|P33412 Saccharomyces cerevisiae YGR007W ECT1 Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; ethanolamine-phosphate cytidylyltransferase 3253 34685204 LALA0_S04e00122g Lachancea lanzarotensis ethanolamine-phosphate cytidylyltransferase XP_022627996.1 2288 R 1245769 CDS LALA0_S04e00144g 34685205 complement(join(3384..4018,4108..4207)) Unknown 1 NW_019212882.1 similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Putative protein of unknown function, predicted to be palmitoylated; uncharacterized protein 4207 34685205 LALA0_S04e00144g Lachancea lanzarotensis uncharacterized protein XP_022627997.1 3384 R 1245769 CDS LALA0_S04e00166g 34685206 complement(4330..5085) Unknown 1 NW_019212882.1 similar to uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p; mRNA splicing protein PRP18 5085 34685206 LALA0_S04e00166g Lachancea lanzarotensis mRNA splicing protein PRP18 XP_022627998.1 4330 R 1245769 CDS LALA0_S04e00188g 34685207 5310..6521 Unknown 1 NW_019212882.1 highly similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30; transcription factor IIF subunit TFG2 6521 34685207 LALA0_S04e00188g Lachancea lanzarotensis transcription factor IIF subunit TFG2 XP_022627999.1 5310 D 1245769 CDS LALA0_S04e00210g 34685208 6885..7121 Unknown 1 NW_019212882.1 highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein; 60S ribosomal protein eL38 7121 34685208 LALA0_S04e00210g Lachancea lanzarotensis 60S ribosomal protein eL38 XP_022628000.1 6885 D 1245769 CDS LALA0_S04e00232g 34685209 complement(7307..8920) Unknown 1 NW_019212882.1 similar to uniprot|P53203 Saccharomyces cerevisiae YGR004W (ohnolog of YLR324W) PEX31 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; uncharacterized protein 8920 34685209 LALA0_S04e00232g Lachancea lanzarotensis uncharacterized protein XP_022628001.1 7307 R 1245769 CDS LALA0_S04e00254g 34685210 9120..9833 Unknown 1 NW_019212882.1 similar to uniprot|P53769 Saccharomyces cerevisiae YLR323C CWC24 Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p; U2-type spliceosomal complex subunit CWC24 9833 34685210 LALA0_S04e00254g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC24 XP_022628002.1 9120 D 1245769 CDS LALA0_S04e00276g 34685211 complement(9863..12043) Unknown 1 NW_019212882.1 similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W CUL3 Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3; cullin CUL3 12043 34685211 LALA0_S04e00276g Lachancea lanzarotensis cullin CUL3 XP_022628003.1 9863 R 1245769 CDS LALA0_S04e00298g 34685212 12220..13605 Unknown 1 NW_019212882.1 similar to uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; uncharacterized protein 13605 34685212 LALA0_S04e00298g Lachancea lanzarotensis uncharacterized protein XP_022628004.1 12220 D 1245769 CDS LALA0_S04e00320g 34685213 complement(13789..17967) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation; uncharacterized protein 17967 34685213 LALA0_S04e00320g Lachancea lanzarotensis uncharacterized protein XP_022628005.1 13789 R 1245769 CDS LALA0_S04e00342g 34685214 19048..21219 Unknown 1 NW_019212882.1 similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate; uncharacterized protein 21219 34685214 LALA0_S04e00342g Lachancea lanzarotensis uncharacterized protein XP_022628006.1 19048 D 1245769 CDS LALA0_S04e00364g 34685215 complement(21513..23666) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia; telomerase reverse transcriptase 23666 34685215 LALA0_S04e00364g Lachancea lanzarotensis telomerase reverse transcriptase XP_022628007.1 21513 R 1245769 CDS LALA0_S04e00386g 34685216 23794..24762 Unknown 1 NW_019212882.1 similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; uncharacterized protein 24762 34685216 LALA0_S04e00386g Lachancea lanzarotensis uncharacterized protein XP_022628008.1 23794 D 1245769 CDS LALA0_S04e00408g 34685217 complement(24759..25226) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q06162 Saccharomyces cerevisiae YLR315W NKP2 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p); uncharacterized protein 25226 34685217 LALA0_S04e00408g Lachancea lanzarotensis uncharacterized protein XP_022628009.1 24759 R 1245769 CDS LALA0_S04e00430g 34685218 complement(25832..26914) Unknown 1 NW_019212882.1 similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; uncharacterized protein 26914 34685218 LALA0_S04e00430g Lachancea lanzarotensis uncharacterized protein XP_022628010.1 25832 R 1245769 CDS LALA0_S04e00452g 34685219 join(27477..27556,27973..28525) Unknown 1 NW_019212882.1 highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; translation elongation factor 1 subunit beta 28525 34685219 LALA0_S04e00452g Lachancea lanzarotensis translation elongation factor 1 subunit beta XP_022628011.1 27477 D 1245769 CDS LALA0_S04e00474g 34685220 28698..32390 Unknown 1 NW_019212882.1 weakly similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif; CORVET complex membrane-binding subunit VPS8 32390 34685220 LALA0_S04e00474g Lachancea lanzarotensis CORVET complex membrane-binding subunit VPS8 XP_022628012.1 28698 D 1245769 CDS LALA0_S04e00496g 34685221 complement(32535..33575) Unknown 1 NW_019212882.1 highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) 33575 34685221 LALA0_S04e00496g Lachancea lanzarotensis sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) XP_022628013.1 32535 R 1245769 CDS LALA0_S04e00540g 34685222 complement(join(34192..34421,34487..34956,35019..35044)) Unknown 1 NW_019212882.1 similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae; protein-lysine N-methyltransferase 35044 34685222 LALA0_S04e00540g Lachancea lanzarotensis protein-lysine N-methyltransferase XP_022628014.1 34192 R 1245769 CDS LALA0_S04e00562g 34685223 join(35274..35340,35404..38861) Unknown 1 NW_019212882.1 similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; transcription factor TFIIIC subunit TFC3 38861 34685223 LALA0_S04e00562g Lachancea lanzarotensis transcription factor TFIIIC subunit TFC3 XP_022628015.1 35274 D 1245769 CDS LALA0_S04e00606g 34685225 join(39457..39537,39600..41078) Unknown 1 NW_019212882.1 weakly similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1; FG-nucleoporin NUP60 41078 34685225 LALA0_S04e00606g Lachancea lanzarotensis FG-nucleoporin NUP60 XP_022628016.1 39457 D 1245769 CDS LALA0_S04e00628g 34685226 complement(41214..41873) Unknown 1 NW_019212882.1 similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A (ohnolog of YGL002W) ERP1 Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; uncharacterized protein 41873 34685226 LALA0_S04e00628g Lachancea lanzarotensis uncharacterized protein XP_022628017.1 41214 R 1245769 CDS LALA0_S04e00650g 34685227 42027..43376 Unknown 1 NW_019212882.1 similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7; COMPASS subunit protein SWD1 43376 34685227 LALA0_S04e00650g Lachancea lanzarotensis COMPASS subunit protein SWD1 XP_022628018.1 42027 D 1245769 CDS LALA0_S04e00672g 34685228 43551..45218 Unknown 1 NW_019212882.1 similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p; uncharacterized protein 45218 34685228 LALA0_S04e00672g Lachancea lanzarotensis uncharacterized protein XP_022628019.1 43551 D 1245769 CDS LALA0_S04e00694g 34685229 complement(45254..47170) Unknown 1 NW_019212882.1 some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 47170 34685229 LALA0_S04e00694g Lachancea lanzarotensis uncharacterized protein XP_022628020.1 45254 R 1245769 CDS LALA0_S04e00716g 34685230 complement(47718..49604) Unknown 1 NW_019212882.1 similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; replication factor A subunit protein RFA1 49604 34685230 LALA0_S04e00716g Lachancea lanzarotensis replication factor A subunit protein RFA1 XP_022628021.1 47718 R 1245769 CDS LALA0_S04e00738g 34685231 50526..51302 Unknown 1 NW_019212882.1 similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG7 51302 34685231 LALA0_S04e00738g Lachancea lanzarotensis Golgi transport complex subunit COG7 XP_022628022.1 50526 D 1245769 CDS LALA0_S04e00760g 34685232 complement(51400..55086) Unknown 1 NW_019212882.1 similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a; calcium-transporting ATPase PMC1 55086 34685232 LALA0_S04e00760g Lachancea lanzarotensis calcium-transporting ATPase PMC1 XP_022628023.1 51400 R 1245769 CDS LALA0_S04e00782g 34685233 57003..57842 Unknown 1 NW_019212882.1 similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W SEN34 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease; tRNA splicing endonuclease subunit SEN34 57842 34685233 LALA0_S04e00782g Lachancea lanzarotensis tRNA splicing endonuclease subunit SEN34 XP_022628024.1 57003 D 1245769 CDS LALA0_S04e00848g 34685235 complement(59007..59702) Unknown 1 NW_019212882.1 similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 59702 34685235 LALA0_S04e00848g Lachancea lanzarotensis uncharacterized protein XP_022628025.1 59007 R 1245769 CDS LALA0_S04e00870g 34685236 59948..60904 Unknown 1 NW_019212882.1 similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation; protein disulfide isomerase MPD1 60904 34685236 LALA0_S04e00870g Lachancea lanzarotensis protein disulfide isomerase MPD1 XP_022628026.1 59948 D 1245769 CDS LALA0_S04e00892g 34685237 join(61423..61480,61552..61790) Unknown 1 NW_019212882.1 similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL53 61790 34685237 LALA0_S04e00892g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL53 XP_022628027.1 61423 D 1245769 CDS LALA0_S04e00914g 34685238 62073..63023 Unknown 1 NW_019212882.1 similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C RRP36 Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; rRNA-processing protein RRP36 63023 34685238 LALA0_S04e00914g Lachancea lanzarotensis rRNA-processing protein RRP36 XP_022628028.1 62073 D 1245769 CDS LALA0_S04e00936g 34685239 complement(63135..63563) Unknown 1 NW_019212882.1 similar to uniprot|Q08742 Saccharomyces cerevisiae YOR286W RDL2 Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 63563 34685239 LALA0_S04e00936g Lachancea lanzarotensis uncharacterized protein XP_022628029.1 63135 R 1245769 CDS LALA0_S04e00958g 34685240 complement(64037..64447) Unknown 1 NW_019212882.1 similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W RDL1 Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; uncharacterized protein 64447 34685240 LALA0_S04e00958g Lachancea lanzarotensis uncharacterized protein XP_022628030.1 64037 R 1245769 CDS LALA0_S04e00980g 34685241 complement(64775..65467) Unknown 1 NW_019212882.1 similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene; phosphoglycerate mutase 65467 34685241 LALA0_S04e00980g Lachancea lanzarotensis phosphoglycerate mutase XP_022628031.1 64775 R 1245769 CDS LALA0_S04e01002g 34685242 65711..67705 Unknown 1 NW_019212882.1 similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved; MRX complex nuclease subunit 67705 34685242 LALA0_S04e01002g Lachancea lanzarotensis MRX complex nuclease subunit XP_022628032.1 65711 D 1245769 CDS LALA0_S04e01024g 34685243 67873..68682 Unknown 1 NW_019212882.1 highly similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C PLP2 Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; uncharacterized protein 68682 34685243 LALA0_S04e01024g Lachancea lanzarotensis uncharacterized protein XP_022628033.1 67873 D 1245769 CDS LALA0_S04e01046g 34685244 complement(68810..70174) Unknown 1 NW_019212882.1 similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B; ubiquitin-specific protease UBP8 70174 34685244 LALA0_S04e01046g Lachancea lanzarotensis ubiquitin-specific protease UBP8 XP_022628034.1 68810 R 1245769 CDS LALA0_S04e01068g 34685245 71581..73827 Unknown 1 NW_019212882.1 similar to uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal; histone acetyltransferase 73827 34685245 LALA0_S04e01068g Lachancea lanzarotensis histone acetyltransferase XP_022628035.1 71581 D 1245769 CDS LALA0_S04e01090g 34685246 complement(74066..75937) Unknown 1 NW_019212882.1 weakly similar to uniprot|P40059 Saccharomyces cerevisiae YER088C (ohnolog of YBL054W) DOT6 Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; uncharacterized protein 75937 34685246 LALA0_S04e01090g Lachancea lanzarotensis uncharacterized protein XP_022628036.1 74066 R 1245769 CDS LALA0_S04e01112g 34685247 complement(77320..78213) Unknown 1 NW_019212882.1 highly similar to uniprot|C5DCU8 Lachancea thermotolerans KLTH0B05962g hypothetical protein; uncharacterized protein 78213 34685247 LALA0_S04e01112g Lachancea lanzarotensis uncharacterized protein XP_022628037.1 77320 R 1245769 CDS LALA0_S04e01134g 34685248 79529..81988 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family; decapping enzyme complex catalytic subunit 81988 34685248 LALA0_S04e01134g Lachancea lanzarotensis decapping enzyme complex catalytic subunit XP_022628038.1 79529 D 1245769 CDS LALA0_S04e01156g 34685249 complement(82157..83578) Unknown 1 NW_019212882.1 similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; uncharacterized protein 83578 34685249 LALA0_S04e01156g Lachancea lanzarotensis uncharacterized protein XP_022628039.1 82157 R 1245769 CDS LALA0_S04e01178g 34685250 84014..84346 Unknown 1 NW_019212882.1 similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 84346 34685250 LALA0_S04e01178g Lachancea lanzarotensis uncharacterized protein XP_022628040.1 84014 D 1245769 CDS LALA0_S04e01200g 34685251 84804..86621 Unknown 1 NW_019212882.1 similar to uniprot|P38825 Saccharomyces cerevisiae YHR117W (ohnolog of YNL121C) TOM71 Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; protein channel TOM70 86621 34685251 LALA0_S04e01200g Lachancea lanzarotensis protein channel TOM70 XP_022628041.1 84804 D 1245769 CDS LALA0_S04e01222g 34685252 87501..87776 Unknown 1 NW_019212882.1 similar to uniprot|P53921 Saccharomyces cerevisiae YNL122C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene; mitochondrial 54S ribosomal protein bL35m 87776 34685252 LALA0_S04e01222g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL35m XP_022628042.1 87501 D 1245769 CDS LALA0_S04e01244g 34685253 complement(87993..90962) Unknown 1 NW_019212882.1 highly similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W NMA111 Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; uncharacterized protein 90962 34685253 LALA0_S04e01244g Lachancea lanzarotensis uncharacterized protein XP_022628043.1 87993 R 1245769 CDS LALA0_S04e01266g 34685254 complement(91289..92587) Unknown 1 NW_019212882.1 similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; origin recognition complex subunit 6 92587 34685254 LALA0_S04e01266g Lachancea lanzarotensis origin recognition complex subunit 6 XP_022628044.1 91289 R 1245769 CDS LALA0_S04e01288g 34685255 93008..96007 Unknown 1 NW_019212882.1 similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain; histone methyltransferase SET1 96007 34685255 LALA0_S04e01288g Lachancea lanzarotensis histone methyltransferase SET1 XP_022628045.1 93008 D 1245769 CDS LALA0_S04e01310g 34685256 96300..99191 Unknown 1 NW_019212882.1 similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis; mismatch repair ATPase MSH1 99191 34685256 LALA0_S04e01310g Lachancea lanzarotensis mismatch repair ATPase MSH1 XP_022628046.1 96300 D 1245769 CDS LALA0_S04e01332g 34685257 complement(99224..100825) Unknown 1 NW_019212882.1 similar to uniprot|P53919 Saccharomyces cerevisiae YNL124W NAF1 RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p; RNA-binding snoRNP assembly protein 100825 34685257 LALA0_S04e01332g Lachancea lanzarotensis RNA-binding snoRNP assembly protein XP_022628047.1 99224 R 1245769 CDS LALA0_S04e01354g 34685258 102162..103934 Unknown 1 NW_019212882.1 similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane; uncharacterized protein 103934 34685258 LALA0_S04e01354g Lachancea lanzarotensis uncharacterized protein XP_022628048.1 102162 D 1245769 CDS LALA0_S04e01376g 34685259 complement(104009..106546) Unknown 1 NW_019212882.1 similar to uniprot|P53540 Saccharomyces cerevisiae YNL126W SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; uncharacterized protein 106546 34685259 LALA0_S04e01376g Lachancea lanzarotensis uncharacterized protein XP_022628049.1 104009 R 1245769 CDS LALA0_S04e01398g 34685260 complement(106748..109522) Unknown 1 NW_019212882.1 similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2; uncharacterized protein 109522 34685260 LALA0_S04e01398g Lachancea lanzarotensis uncharacterized protein XP_022628050.1 106748 R 1245769 CDS LALA0_S04e01420g 34685261 110408..110728 Unknown 1 NW_019212882.1 some similarities with uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; uncharacterized protein 110728 34685261 LALA0_S04e01420g Lachancea lanzarotensis uncharacterized protein XP_022628051.1 110408 D 1245769 CDS LALA0_S04e01442g 34685262 complement(110873..112177) Unknown 1 NW_019212882.1 similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation; uncharacterized protein 112177 34685262 LALA0_S04e01442g Lachancea lanzarotensis uncharacterized protein XP_022628052.1 110873 R 1245769 CDS LALA0_S04e01464g 34685263 complement(join(112315..112965,113048..113107)) Unknown 1 NW_019212882.1 similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis; ribosylnicotinamide kinase 113107 34685263 LALA0_S04e01464g Lachancea lanzarotensis ribosylnicotinamide kinase XP_022628053.1 112315 R 1245769 CDS LALA0_S04e01486g 34685264 113310..113987 Unknown 1 NW_019212882.1 similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene; iron-sulfur cluster assembly protein CIA2 113987 34685264 LALA0_S04e01486g Lachancea lanzarotensis iron-sulfur cluster assembly protein CIA2 XP_022628054.1 113310 D 1245769 CDS LALA0_S04e01508g 34685265 join(114180..114229,114307..115456) Unknown 1 NW_019212882.1 similar to uniprot|P22140 Saccharomyces cerevisiae YHR123W (ohnolog of YNL130C) EPT1 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; diacylglycerol cholinephosphotransferase 115456 34685265 LALA0_S04e01508g Lachancea lanzarotensis diacylglycerol cholinephosphotransferase XP_022628055.1 114180 D 1245769 CDS LALA0_S04e01530g 34685266 complement(115709..116164) Unknown 1 NW_019212882.1 similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes; uncharacterized protein 116164 34685266 LALA0_S04e01530g Lachancea lanzarotensis uncharacterized protein XP_022628056.1 115709 R 1245769 CDS LALA0_S04e01552g 34685267 complement(116509..119664) Unknown 1 NW_019212882.1 highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; ribosome biosynthesis protein KRE33 119664 34685267 LALA0_S04e01552g Lachancea lanzarotensis ribosome biosynthesis protein KRE33 XP_022628057.1 116509 R 1245769 CDS LALA0_S04e01574g 34685268 120448..122481 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE); transcription factor NDT80 122481 34685268 LALA0_S04e01574g Lachancea lanzarotensis transcription factor NDT80 XP_022628058.1 120448 D 1245769 CDS LALA0_S04e01618g 34685270 122870..123400 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining; uncharacterized protein 123400 34685270 LALA0_S04e01618g Lachancea lanzarotensis uncharacterized protein XP_022628059.1 122870 D 1245769 CDS LALA0_S04e01640g 34685271 124168..125280 Unknown 1 NW_019212882.1 similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS; uncharacterized protein 125280 34685271 LALA0_S04e01640g Lachancea lanzarotensis uncharacterized protein XP_022628060.1 124168 D 1245769 CDS LALA0_S04e01662g 34685272 128169..128423 Unknown 1 NW_019212882.1 similar to uniprot|P43497 Saccharomyces cerevisiae YKL096W-A CWP2 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored; uncharacterized protein 128423 34685272 LALA0_S04e01662g Lachancea lanzarotensis uncharacterized protein XP_022628061.1 128169 D 1245769 CDS LALA0_S04e01684g 34685273 129878..130222 Unknown 1 NW_019212882.1 highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; peptidylprolyl isomerase FPR1 130222 34685273 LALA0_S04e01684g Lachancea lanzarotensis peptidylprolyl isomerase FPR1 XP_022628062.1 129878 D 1245769 CDS LALA0_S04e01706g 34685274 complement(130319..131422) Unknown 1 NW_019212882.1 weakly similar to uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A; uncharacterized protein 131422 34685274 LALA0_S04e01706g Lachancea lanzarotensis uncharacterized protein XP_022628063.1 130319 R 1245769 CDS LALA0_S04e01728g 34685275 132401..133834 Unknown 1 NW_019212882.1 similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit; mitochondrial 37S ribosomal protein uS4m 133834 34685275 LALA0_S04e01728g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS4m XP_022628064.1 132401 D 1245769 CDS LALA0_S04e01750g 34685276 complement(133896..135533) Unknown 1 NW_019212882.1 similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; adenylate cyclase-binding protein 135533 34685276 LALA0_S04e01750g Lachancea lanzarotensis adenylate cyclase-binding protein XP_022628065.1 133896 R 1245769 CDS LALA0_S04e01772g 34685277 135969..136625 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38833 Saccharomyces cerevisiae YHR127W Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis; uncharacterized protein 136625 34685277 LALA0_S04e01772g Lachancea lanzarotensis uncharacterized protein XP_022628066.1 135969 D 1245769 CDS LALA0_S04e01794g 34685278 complement(join(136704..136967,137046..137048)) Unknown 1 NW_019212882.1 similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A YSF3 Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b; U2 snRNP complex subunit YSF3 137048 34685278 LALA0_S04e01794g Lachancea lanzarotensis U2 snRNP complex subunit YSF3 XP_022628067.1 136704 R 1245769 CDS LALA0_S04e01816g 34685279 137211..142121 Unknown 1 NW_019212882.1 similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C THO2 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; uncharacterized protein 142121 34685279 LALA0_S04e01816g Lachancea lanzarotensis uncharacterized protein XP_022628068.1 137211 D 1245769 CDS LALA0_S04e01838g 34685280 142643..143839 Unknown 1 NW_019212882.1 similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W INN1 Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; uncharacterized protein 143839 34685280 LALA0_S04e01838g Lachancea lanzarotensis uncharacterized protein XP_022628069.1 142643 D 1245769 CDS LALA0_S04e01860g 34685281 complement(144071..144760) Unknown 1 NW_019212882.1 similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31; DNA-directed RNA polymerase III subunit C31 144760 34685281 LALA0_S04e01860g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit C31 XP_022628070.1 144071 R 1245769 CDS LALA0_S04e01882g 34685282 complement(145003..145383) Unknown 1 NW_019212882.1 similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C PGA2 Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect; uncharacterized protein 145383 34685282 LALA0_S04e01882g Lachancea lanzarotensis uncharacterized protein XP_022628071.1 145003 R 1245769 CDS LALA0_S04e01904g 34685283 complement(145573..146322) Unknown 1 NW_019212882.1 weakly similar to uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance; uncharacterized protein 146322 34685283 LALA0_S04e01904g Lachancea lanzarotensis uncharacterized protein XP_022628072.1 145573 R 1245769 CDS LALA0_S04e01926g 34685284 join(146485..146496,146604..146927) Unknown 1 NW_019212882.1 similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; Sm-like protein LSM7 146927 34685284 LALA0_S04e01926g Lachancea lanzarotensis Sm-like protein LSM7 XP_022628073.1 146485 D 1245769 CDS LALA0_S04e01948g 34685285 147858..148508 Unknown 1 NW_019212882.1 highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway; uracil phosphoribosyltransferase 148508 34685285 LALA0_S04e01948g Lachancea lanzarotensis uracil phosphoribosyltransferase XP_022628074.1 147858 D 1245769 CDS LALA0_S04e01970g 34685286 complement(148626..149777) Unknown 1 NW_019212882.1 similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin; actin-related protein 1 149777 34685286 LALA0_S04e01970g Lachancea lanzarotensis actin-related protein 1 XP_022628075.1 148626 R 1245769 CDS LALA0_S04e01992g 34685287 complement(149946..151772) Unknown 1 NW_019212882.1 highly similar to uniprot|C5DCW1 Lachancea thermotolerans KLTH0B06248g hypothetical protein; uncharacterized protein 151772 34685287 LALA0_S04e01992g Lachancea lanzarotensis uncharacterized protein XP_022628076.1 149946 R 1245769 CDS LALA0_S04e02014g 34685288 complement(153156..155393) Unknown 1 NW_019212882.1 weakly similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C (ohnolog of YNL144C) Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; uncharacterized protein 155393 34685288 LALA0_S04e02014g Lachancea lanzarotensis uncharacterized protein XP_022628077.1 153156 R 1245769 CDS LALA0_S04e02036g 34685289 complement(155896..157080) Unknown 1 NW_019212882.1 weakly similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance; uncharacterized protein 157080 34685289 LALA0_S04e02036g Lachancea lanzarotensis uncharacterized protein XP_022628078.1 155896 R 1245769 CDS LALA0_S04e02058g 34685290 complement(157429..158166) Unknown 1 NW_019212882.1 weakly similar to uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; uncharacterized protein 158166 34685290 LALA0_S04e02058g Lachancea lanzarotensis uncharacterized protein XP_022628079.1 157429 R 1245769 CDS LALA0_S04e02080g 34685291 158924..159469 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W PGA1 Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes; uncharacterized protein 159469 34685291 LALA0_S04e02080g Lachancea lanzarotensis uncharacterized protein XP_022628080.1 158924 D 1245769 CDS LALA0_S04e02102g 34685292 complement(159512..160834) Unknown 1 NW_019212882.1 similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C ECM14 Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly; uncharacterized protein 160834 34685292 LALA0_S04e02102g Lachancea lanzarotensis uncharacterized protein XP_022628081.1 159512 R 1245769 CDS LALA0_S04e02124g 34685293 162027..162416 Unknown 1 NW_019212882.1 similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A (ohnolog of YNL157W) IGO2 Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p; phosphatase regulator 162416 34685293 LALA0_S04e02124g Lachancea lanzarotensis phosphatase regulator XP_022628082.1 162027 D 1245769 CDS LALA0_S04e02146g 34685294 complement(162831..163619) Unknown 1 NW_019212882.1 similar to uniprot|P38837 Saccharomyces cerevisiae YHR133C (ohnolog of YNL156C) NSG1 Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; uncharacterized protein 163619 34685294 LALA0_S04e02146g Lachancea lanzarotensis uncharacterized protein XP_022628083.1 162831 R 1245769 CDS LALA0_S04e02168g 34685295 165016..165792 Unknown 1 NW_019212882.1 similar to uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response; metalloendopeptidase WSS1 165792 34685295 LALA0_S04e02168g Lachancea lanzarotensis metalloendopeptidase WSS1 XP_022628084.1 165016 D 1245769 CDS LALA0_S04e02190g 34685296 166252..167088 Unknown 1 NW_019212882.1 similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Putative protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; uncharacterized protein 167088 34685296 LALA0_S04e02190g Lachancea lanzarotensis uncharacterized protein XP_022628085.1 166252 D 1245769 CDS LALA0_S04e02212g 34685297 167558..168631 Unknown 1 NW_019212882.1 similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C Putative dihydrokaempferol 4-reductase; uncharacterized protein 168631 34685297 LALA0_S04e02212g Lachancea lanzarotensis uncharacterized protein XP_022628086.1 167558 D 1245769 CDS LALA0_S04e02234g 34685298 complement(169073..170578) Unknown 1 NW_019212882.1 similar to uniprot|P23291 Saccharomyces cerevisiae YHR135C (ohnolog of YNL154C) YCK1 Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p; serine/threonine protein kinase YCK2 170578 34685298 LALA0_S04e02234g Lachancea lanzarotensis serine/threonine protein kinase YCK2 XP_022628087.1 169073 R 1245769 CDS LALA0_S04e02256g 34685299 174203..175276 Unknown 1 NW_019212882.1 similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome; adenine deaminase 175276 34685299 LALA0_S04e02256g Lachancea lanzarotensis adenine deaminase XP_022628088.1 174203 D 1245769 CDS LALA0_S04e02278g 34685300 complement(175529..176146) Unknown 1 NW_019212882.1 weakly similar to uniprot|C5DI46 Lachancea thermotolerans KLTH0E09636g hypothetical protein; uncharacterized protein 176146 34685300 LALA0_S04e02278g Lachancea lanzarotensis uncharacterized protein XP_022628089.1 175529 R 1245769 CDS LALA0_S04e02300g 34685301 177685..178053 Unknown 1 NW_019212882.1 similar to uniprot|C5DI46 Lachancea thermotolerans KLTH0E09636g hypothetical protein; uncharacterized protein 178053 34685301 LALA0_S04e02300g Lachancea lanzarotensis uncharacterized protein XP_022628090.1 177685 D 1245769 CDS LALA0_S04e02322g 34685302 179231..180328 Unknown 1 NW_019212882.1 highly similar to uniprot|P50873 Saccharomyces cerevisiae YDL079C (ohnolog of YMR139W) MRK1 Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; uncharacterized protein 180328 34685302 LALA0_S04e02322g Lachancea lanzarotensis uncharacterized protein XP_022628091.1 179231 D 1245769 CDS LALA0_S04e02344g 34685303 181224..183056 Unknown 1 NW_019212882.1 similar to uniprot|Q07471 Saccharomyces cerevisiae YDL080C THI3 Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis; branched-chain-2-oxoacid decarboxylase THI3 183056 34685303 LALA0_S04e02344g Lachancea lanzarotensis branched-chain-2-oxoacid decarboxylase THI3 XP_022628092.1 181224 D 1245769 CDS LALA0_S04e02366g 34685304 185578..188145 Unknown 1 NW_019212882.1 weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance; uncharacterized protein 188145 34685304 LALA0_S04e02366g Lachancea lanzarotensis uncharacterized protein XP_022628093.1 185578 D 1245769 CDS LALA0_S04e02388g 34685305 188510..189319 Unknown 1 NW_019212882.1 similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Putative protein of unknown function; null mutant is viable; mitochondrial HMG-box protein CIM1 189319 34685305 LALA0_S04e02388g Lachancea lanzarotensis mitochondrial HMG-box protein CIM1 XP_022628094.1 188510 D 1245769 CDS LALA0_S04e02410g 34685306 complement(189400..190155) Unknown 1 NW_019212882.1 similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; uncharacterized protein 190155 34685306 LALA0_S04e02410g Lachancea lanzarotensis uncharacterized protein XP_022628095.1 189400 R 1245769 CDS LALA0_S04e02432g 34685307 190524..192392 Unknown 1 NW_019212882.1 similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins; uncharacterized protein 192392 34685307 LALA0_S04e02432g Lachancea lanzarotensis uncharacterized protein XP_022628096.1 190524 D 1245769 CDS LALA0_S04e02454g 34685308 192988..194790 Unknown 1 NW_019212882.1 similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene; uncharacterized protein 194790 34685308 LALA0_S04e02454g Lachancea lanzarotensis uncharacterized protein XP_022628097.1 192988 D 1245769 CDS LALA0_S04e02476g 34685309 complement(194961..196469) Unknown 1 NW_019212882.1 similar to uniprot|P38823 Saccharomyces cerevisiae YHR115C (ohnolog of YNL116W) DMA1 Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.; uncharacterized protein 196469 34685309 LALA0_S04e02476g Lachancea lanzarotensis uncharacterized protein XP_022628098.1 194961 R 1245769 CDS LALA0_S04e02498g 34685310 complement(197630..199321) Unknown 1 NW_019212882.1 highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium; malate synthase MLS1 199321 34685310 LALA0_S04e02498g Lachancea lanzarotensis malate synthase MLS1 XP_022628099.1 197630 R 1245769 CDS LALA0_S04e02520g 34685311 200999..202312 Unknown 1 NW_019212882.1 similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; uncharacterized protein 202312 34685311 LALA0_S04e02520g Lachancea lanzarotensis uncharacterized protein XP_022628100.1 200999 D 1245769 CDS LALA0_S04e02542g 34685312 202745..203794 Unknown 1 NW_019212882.1 similar to uniprot|P47181 Saccharomyces cerevisiae YJR154W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 203794 34685312 LALA0_S04e02542g Lachancea lanzarotensis uncharacterized protein XP_022628101.1 202745 D 1245769 CDS LALA0_S04e02564g 34685313 204358..205326 Unknown 1 NW_019212882.1 similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 205326 34685313 LALA0_S04e02564g Lachancea lanzarotensis 3-methyl-2-oxobutanoate hydroxymethyltransferase XP_022628102.1 204358 D 1245769 CDS LALA0_S04e02586g 34685314 complement(205350..206774) Unknown 1 NW_019212882.1 similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C FMP30 Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE- specific phospholipase D; N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D 206774 34685314 LALA0_S04e02586g Lachancea lanzarotensis N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D XP_022628103.1 205350 R 1245769 CDS LALA0_S04e02608g 34685315 207190..208530 Unknown 1 NW_019212882.1 similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; Elongator subunit ELP4 208530 34685315 LALA0_S04e02608g Lachancea lanzarotensis Elongator subunit ELP4 XP_022628104.1 207190 D 1245769 CDS LALA0_S04e02630g 34685316 208706..209908 Unknown 1 NW_019212882.1 similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; uncharacterized protein 209908 34685316 LALA0_S04e02630g Lachancea lanzarotensis uncharacterized protein XP_022628105.1 208706 D 1245769 CDS LALA0_S04e02652g 34685317 complement(209976..210488) Unknown 1 NW_019212882.1 similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C AIM43 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 210488 34685317 LALA0_S04e02652g Lachancea lanzarotensis uncharacterized protein XP_022628106.1 209976 R 1245769 CDS LALA0_S04e02674g 34685318 complement(210636..211004) Unknown 1 NW_019212882.1 similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C MGR2 Protein required for growth of cells lacking the mitochondrial genome; uncharacterized protein 211004 34685318 LALA0_S04e02674g Lachancea lanzarotensis uncharacterized protein XP_022628107.1 210636 R 1245769 CDS LALA0_S04e02696g 34685319 211926..213332 Unknown 1 NW_019212882.1 similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W MSY1 Mitochondrial tyrosyl-tRNA synthetase; tyrosine--tRNA ligase MSY1 213332 34685319 LALA0_S04e02696g Lachancea lanzarotensis tyrosine--tRNA ligase MSY1 XP_022628108.1 211926 D 1245769 CDS LALA0_S04e02718g 34685320 complement(213431..213637) Unknown 1 NW_019212882.1 similar to uniprot|P62651 Saccharomyces cerevisiae YPL096C-A ERI1 Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein; uncharacterized protein 213637 34685320 LALA0_S04e02718g Lachancea lanzarotensis uncharacterized protein XP_022628109.1 213431 R 1245769 CDS LALA0_S04e02740g 34685321 213780..214817 Unknown 1 NW_019212882.1 similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase 214817 34685321 LALA0_S04e02740g Lachancea lanzarotensis peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase XP_022628110.1 213780 D 1245769 CDS LALA0_S04e02762g 34685322 complement(214890..216251) Unknown 1 NW_019212882.1 similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C (ohnolog of YPL095C) EHT1 Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; uncharacterized protein 216251 34685322 LALA0_S04e02762g Lachancea lanzarotensis uncharacterized protein XP_022628111.1 214890 R 1245769 CDS LALA0_S04e02784g 34685323 complement(216608..219139) Unknown 1 NW_019212882.1 similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; mitofusin 219139 34685323 LALA0_S04e02784g Lachancea lanzarotensis mitofusin XP_022628112.1 216608 R 1245769 CDS LALA0_S04e02806g 34685324 complement(219465..220199) Unknown 1 NW_019212882.1 similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C SEC62 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; Sec63 complex subunit SEC62 220199 34685324 LALA0_S04e02806g Lachancea lanzarotensis Sec63 complex subunit SEC62 XP_022628113.1 219465 R 1245769 CDS LALA0_S04e02828g 34685325 221127..223073 Unknown 1 NW_019212882.1 highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; uncharacterized protein 223073 34685325 LALA0_S04e02828g Lachancea lanzarotensis uncharacterized protein XP_022628114.1 221127 D 1245769 CDS LALA0_S04e02850g 34685326 223422..225092 Unknown 1 NW_019212882.1 similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; uncharacterized protein 225092 34685326 LALA0_S04e02850g Lachancea lanzarotensis uncharacterized protein XP_022628115.1 223422 D 1245769 CDS LALA0_S04e02872g 34685327 226278..227678 Unknown 1 NW_019212882.1 similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein; uncharacterized protein 227678 34685327 LALA0_S04e02872g Lachancea lanzarotensis uncharacterized protein XP_022628116.1 226278 D 1245769 CDS LALA0_S04e02894g 34685328 228181..229629 Unknown 1 NW_019212882.1 highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; glutathione-disulfide reductase GLR1 229629 34685328 LALA0_S04e02894g Lachancea lanzarotensis glutathione-disulfide reductase GLR1 XP_022628117.1 228181 D 1245769 CDS LALA0_S04e02916g 34685329 complement(join(229924..230628,230981..230986)) Unknown 1 NW_019212882.1 highly similar to uniprot|P0CX38 Saccharomyces cerevisiae YBR181C (ohnolog of YPL090C) RPS6B Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein; 40S ribosomal protein eS6 230986 34685329 LALA0_S04e02916g Lachancea lanzarotensis 40S ribosomal protein eS6 XP_022628118.1 229924 R 1245769 CDS LALA0_S04e02938g 34685330 complement(join(231851..233714,233813..233868)) Unknown 1 NW_019212882.1 weakly similar to uniprot|P38128 Saccharomyces cerevisiae YBR182C (ohnolog of YPL089C) SMP1 Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors; uncharacterized protein 233868 34685330 LALA0_S04e02938g Lachancea lanzarotensis uncharacterized protein XP_022628119.1 231851 R 1245769 CDS LALA0_S04e02960g 34685331 235451..236410 Unknown 1 NW_019212882.1 similar to uniprot|P38298 Saccharomyces cerevisiae YBR183W (ohnolog of YPL087W) YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; alkaline dihydroceramidase 236410 34685331 LALA0_S04e02960g Lachancea lanzarotensis alkaline dihydroceramidase XP_022628120.1 235451 D 1245769 CDS LALA0_S04e02982g 34685332 236794..237951 Unknown 1 NW_019212882.1 similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; uncharacterized protein 237951 34685332 LALA0_S04e02982g Lachancea lanzarotensis uncharacterized protein XP_022628121.1 236794 D 1245769 CDS LALA0_S04e03004g 34685333 complement(237953..239626) Unknown 1 NW_019212882.1 highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; Elongator subunit ELP3 239626 34685333 LALA0_S04e03004g Lachancea lanzarotensis Elongator subunit ELP3 XP_022628122.1 237953 R 1245769 CDS LALA0_S04e03026g 34685334 240872..247747 Unknown 1 NW_019212882.1 weakly similar to uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p; uncharacterized protein 247747 34685334 LALA0_S04e03026g Lachancea lanzarotensis uncharacterized protein XP_022628123.1 240872 D 1245769 CDS LALA0_S04e03048g 34685335 complement(247931..248776) Unknown 1 NW_019212882.1 similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane; uncharacterized protein 248776 34685335 LALA0_S04e03048g Lachancea lanzarotensis uncharacterized protein XP_022628124.1 247931 R 1245769 CDS LALA0_S04e03070g 34685336 250213..252657 Unknown 1 NW_019212882.1 similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; uncharacterized protein 252657 34685336 LALA0_S04e03070g Lachancea lanzarotensis uncharacterized protein XP_022628125.1 250213 D 1245769 CDS LALA0_S04e03092g 34685337 complement(252640..253980) Unknown 1 NW_019212882.1 similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; tRNA splicing endonuclease subunit SEN54 253980 34685337 LALA0_S04e03092g Lachancea lanzarotensis tRNA splicing endonuclease subunit SEN54 XP_022628126.1 252640 R 1245769 CDS LALA0_S04e03114g 34685338 complement(254294..254488) Unknown 1 NW_019212882.1 hypothetical protein; uncharacterized protein 254488 34685338 LALA0_S04e03114g Lachancea lanzarotensis uncharacterized protein XP_022628127.1 254294 R 1245769 CDS LALA0_S04e03136g 34685339 join(254903..256381,256469..256627) Unknown 1 NW_019212882.1 similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; uncharacterized protein 256627 34685339 LALA0_S04e03136g Lachancea lanzarotensis uncharacterized protein XP_022628128.1 254903 D 1245769 CDS LALA0_S04e03158g 34685340 256942..257787 Unknown 1 NW_019212882.1 similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W GDT1 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; uncharacterized protein 257787 34685340 LALA0_S04e03158g Lachancea lanzarotensis uncharacterized protein XP_022628129.1 256942 D 1245769 CDS LALA0_S04e03180g 34685341 complement(257858..258262) Unknown 1 NW_019212882.1 weakly similar to uniprot|P38302 Saccharomyces cerevisiae YBR188C NTC20 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; uncharacterized protein 258262 34685341 LALA0_S04e03180g Lachancea lanzarotensis uncharacterized protein XP_022628130.1 257858 R 1245769 CDS LALA0_S04e03202g 34685342 complement(258505..264156) Unknown 1 NW_019212882.1 highly similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; DNA-binding ATPase 264156 34685342 LALA0_S04e03202g Lachancea lanzarotensis DNA-binding ATPase XP_022628131.1 258505 R 1245769 CDS LALA0_S04e03224g 34685343 265229..266413 Unknown 1 NW_019212882.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W (ohnolog of YDL182W) LYS21 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p; uncharacterized protein 266413 34685343 LALA0_S04e03224g Lachancea lanzarotensis uncharacterized protein XP_022628132.1 265229 D 1245769 CDS LALA0_S04e03246g 34685344 join(267027..267036,267485..268065) Unknown 1 NW_019212882.1 highly similar to uniprot|P05755 Saccharomyces cerevisiae YBR189W (ohnolog of YPL081W) RPS9B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins; 40S ribosomal protein uS4 268065 34685344 LALA0_S04e03246g Lachancea lanzarotensis 40S ribosomal protein uS4 XP_022628133.1 267027 D 1245769 CDS LALA0_S04e03268g 34685345 join(268901..268911,269283..269754) Unknown 1 NW_019212882.1 highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W (ohnolog of YPL079W) RPL21A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein; 60S ribosomal protein eL21 269754 34685345 LALA0_S04e03268g Lachancea lanzarotensis 60S ribosomal protein eL21 XP_022628134.1 268901 D 1245769 CDS LALA0_S04e03290g 34685346 270951..272051 Unknown 1 NW_019212882.1 highly similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family; uncharacterized protein 272051 34685346 LALA0_S04e03290g Lachancea lanzarotensis uncharacterized protein XP_022628135.1 270951 D 1245769 CDS LALA0_S04e03312g 34685347 complement(272165..272812) Unknown 1 NW_019212882.1 similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; uncharacterized protein 272812 34685347 LALA0_S04e03312g Lachancea lanzarotensis uncharacterized protein XP_022628136.1 272165 R 1245769 CDS LALA0_S04e03334g 34685348 complement(join(273196..273835,274141..274211)) Unknown 1 NW_019212882.1 highly similar to uniprot|P05626 Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated; F1F0 ATP synthase subunit 4 274211 34685348 LALA0_S04e03334g Lachancea lanzarotensis F1F0 ATP synthase subunit 4 XP_022628137.1 273196 R 1245769 CDS LALA0_S04e03356g 34685349 complement(274500..275819) Unknown 1 NW_019212882.1 similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; uncharacterized protein 275819 34685349 LALA0_S04e03356g Lachancea lanzarotensis uncharacterized protein XP_022628138.1 274500 R 1245769 CDS LALA0_S04e03378g 34685350 complement(276078..277745) Unknown 1 NW_019212882.1 highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation; glucose-6-phosphate isomerase 277745 34685350 LALA0_S04e03378g Lachancea lanzarotensis glucose-6-phosphate isomerase XP_022628139.1 276078 R 1245769 CDS LALA0_S04e03400g 34685351 complement(278429..278851) Unknown 1 NW_019212882.1 some similarities with uniprot|P38306 Saccharomyces cerevisiae YBR197C (ohnolog of YPL077C) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; uncharacterized protein 278851 34685351 LALA0_S04e03400g Lachancea lanzarotensis uncharacterized protein XP_022628140.1 278429 R 1245769 CDS LALA0_S04e03422g 34685352 278993..279820 Unknown 1 NW_019212882.1 similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; phosphatidylinositol N-acetylglucosaminyltransferase 279820 34685352 LALA0_S04e03422g Lachancea lanzarotensis phosphatidylinositol N-acetylglucosaminyltransferase XP_022628141.1 278993 D 1245769 CDS LALA0_S04e03444g 34685353 complement(279910..282180) Unknown 1 NW_019212882.1 similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; chromatin modification protein 282180 34685353 LALA0_S04e03444g Lachancea lanzarotensis chromatin modification protein XP_022628142.1 279910 R 1245769 CDS LALA0_S04e03466g 34685354 284184..286241 Unknown 1 NW_019212882.1 weakly similar to uniprot|P07261 Saccharomyces cerevisiae YPL075W GCR1 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; transcription regulator GCR1 286241 34685354 LALA0_S04e03466g Lachancea lanzarotensis transcription regulator GCR1 XP_022628143.1 284184 D 1245769 CDS LALA0_S04e03488g 34685355 286717..288882 Unknown 1 NW_019212882.1 similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells; uncharacterized protein 288882 34685355 LALA0_S04e03488g Lachancea lanzarotensis uncharacterized protein XP_022628144.1 286717 D 1245769 CDS LALA0_S04e03510g 34685356 289922..292195 Unknown 1 NW_019212882.1 some similarities with uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria; uncharacterized protein 292195 34685356 LALA0_S04e03510g Lachancea lanzarotensis uncharacterized protein XP_022628145.1 289922 D 1245769 CDS LALA0_S04e03532g 34685357 join(292434..292442,292670..294334) Unknown 1 NW_019212882.1 similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p; phosphatidylinositol-3-phosphate-binding protein BEM1 294334 34685357 LALA0_S04e03532g Lachancea lanzarotensis phosphatidylinositol-3-phosphate-binding protein BEM1 XP_022628146.1 292434 D 1245769 CDS LALA0_S04e03554g 34685358 complement(294486..294935) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 294935 34685358 LALA0_S04e03554g Lachancea lanzarotensis uncharacterized protein XP_022628147.1 294486 R 1245769 CDS LALA0_S04e03576g 34685359 295296..296876 Unknown 1 NW_019212882.1 similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation; guanine nucleotide exchange factor MUK1 296876 34685359 LALA0_S04e03576g Lachancea lanzarotensis guanine nucleotide exchange factor MUK1 XP_022628148.1 295296 D 1245769 CDS LALA0_S04e03598g 34685360 complement(297002..297976) Unknown 1 NW_019212882.1 similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic; farnesyltranstransferase 297976 34685360 LALA0_S04e03598g Lachancea lanzarotensis farnesyltranstransferase XP_022628149.1 297002 R 1245769 CDS LALA0_S04e03620g 34685361 298748..299461 Unknown 1 NW_019212882.1 similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; derlin 299461 34685361 LALA0_S04e03620g Lachancea lanzarotensis derlin XP_022628150.1 298748 D 1245769 CDS LALA0_S04e03642g 34685362 complement(299570..300331) Unknown 1 NW_019212882.1 weakly similar to uniprot|C5DIG7 Lachancea thermotolerans KLTH0E12386g hypothetical protein; uncharacterized protein 300331 34685362 LALA0_S04e03642g Lachancea lanzarotensis uncharacterized protein XP_022628151.1 299570 R 1245769 CDS LALA0_S04e03664g 34685363 complement(300708..301262) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene; uncharacterized protein 301262 34685363 LALA0_S04e03664g Lachancea lanzarotensis uncharacterized protein XP_022628152.1 300708 R 1245769 CDS LALA0_S04e03686g 34685364 302924..305359 Unknown 1 NW_019212882.1 highly similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W MCM7 Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex; DNA replication licensing factor MCM7 305359 34685364 LALA0_S04e03686g Lachancea lanzarotensis DNA replication licensing factor MCM7 XP_022628153.1 302924 D 1245769 CDS LALA0_S04e03708g 34685365 join(305697..305774,305843..307069) Unknown 1 NW_019212882.1 similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source; uncharacterized protein 307069 34685365 LALA0_S04e03708g Lachancea lanzarotensis uncharacterized protein XP_022628154.1 305697 D 1245769 CDS LALA0_S04e03730g 34685366 307370..308059 Unknown 1 NW_019212882.1 similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; ESCRT-I subunit protein VPS28 308059 34685366 LALA0_S04e03730g Lachancea lanzarotensis ESCRT-I subunit protein VPS28 XP_022628155.1 307370 D 1245769 CDS LALA0_S04e03752g 34685367 complement(308068..309045) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q02770 Saccharomyces cerevisiae YPL064C CWC27 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; uncharacterized protein 309045 34685367 LALA0_S04e03752g Lachancea lanzarotensis uncharacterized protein XP_022628156.1 308068 R 1245769 CDS LALA0_S04e03774g 34685368 309217..310632 Unknown 1 NW_019212882.1 similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel; protein translocase subunit TIM50 310632 34685368 LALA0_S04e03774g Lachancea lanzarotensis protein translocase subunit TIM50 XP_022628157.1 309217 D 1245769 CDS LALA0_S04e03796g 34685369 311123..313546 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 313546 34685369 LALA0_S04e03796g Lachancea lanzarotensis uncharacterized protein XP_022628158.1 311123 D 1245769 CDS LALA0_S04e03818g 34685370 314452..316017 Unknown 1 NW_019212882.1 highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress; aldehyde dehydrogenase (NADP(+)) ALD6 316017 34685370 LALA0_S04e03818g Lachancea lanzarotensis aldehyde dehydrogenase (NADP(+)) ALD6 XP_022628159.1 314452 D 1245769 CDS LALA0_S04e03840g 34685371 complement(316115..317125) Unknown 1 NW_019212882.1 similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C LDH1 Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif); triacylglycerol lipase 317125 34685371 LALA0_S04e03840g Lachancea lanzarotensis triacylglycerol lipase XP_022628160.1 316115 R 1245769 CDS LALA0_S04e03862g 34685372 317266..318240 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53324 Saccharomyces cerevisiae YGR263C SAY1 Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; steryl deacetylase 318240 34685372 LALA0_S04e03862g Lachancea lanzarotensis steryl deacetylase XP_022628161.1 317266 D 1245769 CDS LALA0_S04e03884g 34685373 319056..320294 Unknown 1 NW_019212882.1 similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; mannosyltransferase KTR3 320294 34685373 LALA0_S04e03884g Lachancea lanzarotensis mannosyltransferase KTR3 XP_022628162.1 319056 D 1245769 CDS LALA0_S04e03906g 34685374 320519..321712 Unknown 1 NW_019212882.1 similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W MFM1 Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; uncharacterized protein 321712 34685374 LALA0_S04e03906g Lachancea lanzarotensis uncharacterized protein XP_022628163.1 320519 D 1245769 CDS LALA0_S04e03928g 34685375 322117..323439 Unknown 1 NW_019212882.1 similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; uncharacterized protein 323439 34685375 LALA0_S04e03928g Lachancea lanzarotensis uncharacterized protein XP_022628164.1 322117 D 1245769 CDS LALA0_S04e03950g 34685376 complement(323529..329030) Unknown 1 NW_019212882.1 highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1,2 Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; bifunctional urea carboxylase/allophanate hydrolase 329030 34685376 LALA0_S04e03950g Lachancea lanzarotensis bifunctional urea carboxylase/allophanate hydrolase XP_022628165.1 323529 R 1245769 CDS LALA0_S04e03972g 34685377 329914..330327 Unknown 1 NW_019212882.1 similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radicalresponsive glutathione-dependent oxidoreductase;mitochondrial matrix protein involved in thesynthesis/assembly of iron-sulfur centers; monothiolglutaredoxin subfamily member along with Grx3p and Grx4p; monothiol glutaredoxin GRX5 330327 34685377 LALA0_S04e03972g Lachancea lanzarotensis monothiol glutaredoxin GRX5 XP_022628166.1 329914 D 1245769 CDS LALA0_S04e03994g 34685378 complement(330891..332564) Unknown 1 NW_019212882.1 similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W EXO5 Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2; uncharacterized protein 332564 34685378 LALA0_S04e03994g Lachancea lanzarotensis uncharacterized protein XP_022628167.1 330891 R 1245769 CDS LALA0_S04e04016g 34685379 complement(333048..333236) Unknown 1 NW_019212882.1 similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A YSY6 Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion; uncharacterized protein 333236 34685379 LALA0_S04e04016g Lachancea lanzarotensis uncharacterized protein XP_022628168.1 333048 R 1245769 CDS LALA0_S04e04038g 34685380 complement(334168..334779) Unknown 1 NW_019212882.1 hypothetical protein; uncharacterized protein 334779 34685380 LALA0_S04e04038g Lachancea lanzarotensis uncharacterized protein XP_022628169.1 334168 R 1245769 CDS LALA0_S04e04060g 34685381 336021..337409 Unknown 1 NW_019212882.1 similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C; uncharacterized protein 337409 34685381 LALA0_S04e04060g Lachancea lanzarotensis uncharacterized protein XP_022628170.1 336021 D 1245769 CDS LALA0_S04e04082g 34685382 complement(338130..339230) Unknown 1 NW_019212882.1 similar to uniprot|P38287 Saccharomyces cerevisiae YBR161W (ohnolog of YPL057C) CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 339230 34685382 LALA0_S04e04082g Lachancea lanzarotensis mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 XP_022628171.1 338130 R 1245769 CDS LALA0_S04e04104g 34685383 342481..343839 Unknown 1 NW_019212882.1 weakly similar to uniprot|C5DCQ7 Lachancea thermotolerans KLTH0B05038g hypothetical protein; uncharacterized protein 343839 34685383 LALA0_S04e04104g Lachancea lanzarotensis uncharacterized protein XP_022628172.1 342481 D 1245769 CDS LALA0_S04e04126g 34685384 complement(join(344173..344556,344558..344977)) Unknown 1 NW_019212882.1 similar to uniprot|C5DIE2 Lachancea thermotolerans KLTH0E11814g hypothetical protein; 344977 34685384 LALA0_S04e04126g Lachancea lanzarotensis 344173 R 1245769 CDS LALA0_S04e04148g 34685385 complement(347244..348134) Unknown 1 NW_019212882.1 highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; cyclin-dependent serine/threonine-protein kinase CDC28 348134 34685385 LALA0_S04e04148g Lachancea lanzarotensis cyclin-dependent serine/threonine-protein kinase CDC28 XP_022628173.1 347244 R 1245769 CDS LALA0_S04e04170g 34685386 complement(348318..349349) Unknown 1 NW_019212882.1 highly similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W IFA38 Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides; ketoreductase 349349 34685386 LALA0_S04e04170g Lachancea lanzarotensis ketoreductase XP_022628174.1 348318 R 1245769 CDS LALA0_S04e04192g 34685387 complement(join(349615..350260,350355..350374)) Unknown 1 NW_019212882.1 some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division; uncharacterized protein 350374 34685387 LALA0_S04e04192g Lachancea lanzarotensis uncharacterized protein XP_022628175.1 349615 R 1245769 CDS LALA0_S04e04214g 34685388 complement(350789..352303) Unknown 1 NW_019212882.1 similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); uncharacterized protein 352303 34685388 LALA0_S04e04214g Lachancea lanzarotensis uncharacterized protein XP_022628176.1 350789 R 1245769 CDS LALA0_S04e04236g 34685389 354456..355844 Unknown 1 NW_019212882.1 some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Zinc-finger protein of unknown function; uncharacterized protein 355844 34685389 LALA0_S04e04236g Lachancea lanzarotensis uncharacterized protein XP_022628177.1 354456 D 1245769 CDS LALA0_S04e04258g 34685390 357050..358024 Unknown 1 NW_019212882.1 weakly similar to Lachancea thermotolerans KLTH0E11704g hypothetical protein; uncharacterized protein 358024 34685390 LALA0_S04e04258g Lachancea lanzarotensis uncharacterized protein XP_022628178.1 357050 D 1245769 CDS LALA0_S04e04280g 34685391 359572..361818 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; uncharacterized protein 361818 34685391 LALA0_S04e04280g Lachancea lanzarotensis uncharacterized protein XP_022628179.1 359572 D 1245769 CDS LALA0_S04e04302g 34685392 complement(361884..363008) Unknown 1 NW_019212882.1 similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; HSP70/90 family co-chaperone CNS1 363008 34685392 LALA0_S04e04302g Lachancea lanzarotensis HSP70/90 family co-chaperone CNS1 XP_022628180.1 361884 R 1245769 CDS LALA0_S04e04324g 34685393 complement(363948..365285) Unknown 1 NW_019212882.1 similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W (ohnolog of YPL053C) KRE2 Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation; uncharacterized protein 365285 34685393 LALA0_S04e04324g Lachancea lanzarotensis uncharacterized protein XP_022628181.1 363948 R 1245769 CDS LALA0_S04e04346g 34685394 366579..367169 Unknown 1 NW_019212882.1 similar to uniprot|C5DIB0 Lachancea thermotolerans KLTH0E11088g hypothetical protein; 367169 34685394 LALA0_S04e04346g Lachancea lanzarotensis 366579 D 1245769 CDS LALA0_S04e04368g 34685395 367618..368031 Unknown 1 NW_019212882.1 similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C CWC21 Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p; U2-type spliceosomal complex subunit CWC21 368031 34685395 LALA0_S04e04368g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC21 XP_022628182.1 367618 D 1245769 CDS LALA0_S04e04390g 34685396 368486..369079 Unknown 1 NW_019212882.1 highly similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; Arf family GTPase ARL3 369079 34685396 LALA0_S04e04390g Lachancea lanzarotensis Arf family GTPase ARL3 XP_022628183.1 368486 D 1245769 CDS LALA0_S04e04412g 34685397 369915..371546 Unknown 1 NW_019212882.1 similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN; alkaline phosphatase PHO8 371546 34685397 LALA0_S04e04412g Lachancea lanzarotensis alkaline phosphatase PHO8 XP_022628184.1 369915 D 1245769 CDS LALA0_S04e04434g 34685398 complement(371692..372876) Unknown 1 NW_019212882.1 highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; mannosyltransferase complex subunit MNN9 372876 34685398 LALA0_S04e04434g Lachancea lanzarotensis mannosyltransferase complex subunit MNN9 XP_022628185.1 371692 R 1245769 CDS LALA0_S04e04456g 34685399 complement(373470..374672) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q03373 Saccharomyces cerevisiae YDR480W (ohnolog of YPL049C) DIG2 MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; uncharacterized protein 374672 34685399 LALA0_S04e04456g Lachancea lanzarotensis uncharacterized protein XP_022628186.1 373470 R 1245769 CDS LALA0_S04e04478g 34685400 375833..377080 Unknown 1 NW_019212882.1 similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; translation elongation factor EF1B gamma 377080 34685400 LALA0_S04e04478g Lachancea lanzarotensis translation elongation factor EF1B gamma XP_022628187.1 375833 D 1245769 CDS LALA0_S04e04500g 34685401 378391..379929 Unknown 1 NW_019212882.1 highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; catalase A 379929 34685401 LALA0_S04e04500g Lachancea lanzarotensis catalase A XP_022628188.1 378391 D 1245769 CDS LALA0_S04e04522g 34685402 380221..380517 Unknown 1 NW_019212882.1 similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation; SAGA histone acetyltransferase complex subunit SGF11 380517 34685402 LALA0_S04e04522g Lachancea lanzarotensis SAGA histone acetyltransferase complex subunit SGF11 XP_022628189.1 380221 D 1245769 CDS LALA0_S04e04544g 34685403 380875..382086 Unknown 1 NW_019212882.1 similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain; ubiquitin-protein ligase RMD5 382086 34685403 LALA0_S04e04544g Lachancea lanzarotensis ubiquitin-protein ligase RMD5 XP_022628190.1 380875 D 1245769 CDS LALA0_S04e04566g 34685404 complement(382122..382415) Unknown 1 NW_019212882.1 similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair; elongin C 382415 34685404 LALA0_S04e04566g Lachancea lanzarotensis elongin C XP_022628191.1 382122 R 1245769 CDS LALA0_S04e04588g 34685405 382587..384989 Unknown 1 NW_019212882.1 similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages; tethering complex subunit VPS16 384989 34685405 LALA0_S04e04588g Lachancea lanzarotensis tethering complex subunit VPS16 XP_022628192.1 382587 D 1245769 CDS LALA0_S04e04610g 34685406 complement(385013..386158) Unknown 1 NW_019212882.1 weakly similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; uncharacterized protein 386158 34685406 LALA0_S04e04610g Lachancea lanzarotensis uncharacterized protein XP_022628193.1 385013 R 1245769 CDS LALA0_S04e04632g 34685407 386486..388609 Unknown 1 NW_019212882.1 similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); mRNA-binding ribosome biosynthesis protein NOP4 388609 34685407 LALA0_S04e04632g Lachancea lanzarotensis mRNA-binding ribosome biosynthesis protein NOP4 XP_022628194.1 386486 D 1245769 CDS LALA0_S04e04654g 34685408 complement(388785..390485) Unknown 1 NW_019212882.1 similar to uniprot|P39073 Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression; cyclin-dependent serine/threonine protein kinase SSN3 390485 34685408 LALA0_S04e04654g Lachancea lanzarotensis cyclin-dependent serine/threonine protein kinase SSN3 XP_022628195.1 388785 R 1245769 CDS LALA0_S04e04676g 34685409 complement(390679..391323) Unknown 1 NW_019212882.1 similar to uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Protein of unknown function involved in maintenance of proper telomere length; uncharacterized protein 391323 34685409 LALA0_S04e04676g Lachancea lanzarotensis uncharacterized protein XP_022628196.1 390679 R 1245769 CDS LALA0_S04e04698g 34685410 complement(391437..394409) Unknown 1 NW_019212882.1 similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth; isoleucine--tRNA ligase ISM1 394409 34685410 LALA0_S04e04698g Lachancea lanzarotensis isoleucine--tRNA ligase ISM1 XP_022628197.1 391437 R 1245769 CDS LALA0_S04e04720g 34685411 395284..395955 Unknown 1 NW_019212882.1 weakly similar to uniprot|Q12041 Saccharomyces cerevisiae YDR253C (ohnolog of YPL038W) MET32 Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p; uncharacterized protein 395955 34685411 LALA0_S04e04720g Lachancea lanzarotensis uncharacterized protein XP_022628198.1 395284 D 1245769 CDS LALA0_S04e04742g 34685412 complement(396241..396723) Unknown 1 NW_019212882.1 similar to uniprot|P40314 Saccharomyces cerevisiae YDR252W (ohnolog of YPL037C) BTT1 Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; uncharacterized protein 396723 34685412 LALA0_S04e04742g Lachancea lanzarotensis uncharacterized protein XP_022628199.1 396241 R 1245769 CDS LALA0_S04e04786g 34685414 complement(398524..401220) Unknown 1 NW_019212882.1 similar to uniprot|P37304 Saccharomyces cerevisiae YDR251W (ohnolog of YPL032C) PAM1 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; uncharacterized protein 401220 34685414 LALA0_S04e04786g Lachancea lanzarotensis uncharacterized protein XP_022628200.1 398524 R 1245769 CDS LALA0_S04e04808g 34685415 complement(404275..405036) Unknown 1 NW_019212882.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 405036 34685415 LALA0_S04e04808g Lachancea lanzarotensis uncharacterized protein XP_022628201.1 404275 R 1245769 CDS LALA0_S04e04830g 34685416 406375..407487 Unknown 1 NW_019212882.1 weakly similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Putative protein of unknown function; uncharacterized protein 407487 34685416 LALA0_S04e04830g Lachancea lanzarotensis uncharacterized protein XP_022628202.1 406375 D 1245769 CDS LALA0_S04e04852g 34685417 complement(join(407565..408456,408753..408769)) Unknown 1 NW_019212882.1 highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; cyclin-dependent serine/threonine-protein kinase PHO85 408769 34685417 LALA0_S04e04852g Lachancea lanzarotensis cyclin-dependent serine/threonine-protein kinase PHO85 XP_022628203.1 407565 R 1245769 CDS LALA0_S04e04874g 34685418 409031..410623 Unknown 1 NW_019212882.1 similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W TRM44 tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene; tRNA (uracil) methyltransferase 410623 34685418 LALA0_S04e04874g Lachancea lanzarotensis tRNA (uracil) methyltransferase XP_022628204.1 409031 D 1245769 CDS LALA0_S04e04896g 34685419 410800..413022 Unknown 1 NW_019212882.1 similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; ATP-dependent RNA helicase SUV3 413022 34685419 LALA0_S04e04896g Lachancea lanzarotensis ATP-dependent RNA helicase SUV3 XP_022628205.1 410800 D 1245769 CDS LALA0_S04e04918g 34685420 413334..414524 Unknown 1 NW_019212882.1 highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; acetyl-CoA C-acetyltransferase 414524 34685420 LALA0_S04e04918g Lachancea lanzarotensis acetyl-CoA C-acetyltransferase XP_022628206.1 413334 D 1245769 CDS LALA0_S04e04940g 34685421 414934..415494 Unknown 1 NW_019212882.1 similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1; gluconokinase 415494 34685421 LALA0_S04e04940g Lachancea lanzarotensis gluconokinase XP_022628207.1 414934 D 1245769 CDS LALA0_S04e04962g 34685422 complement(415830..417203) Unknown 1 NW_019212882.1 similar to uniprot|Q03785 Saccharomyces cerevisiae YDR247W (ohnolog of YPL026C) VHS1 Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p; uncharacterized protein 417203 34685422 LALA0_S04e04962g Lachancea lanzarotensis uncharacterized protein XP_022628208.1 415830 R 1245769 CDS LALA0_S04e04984g 34685423 complement(420118..421326) Unknown 1 NW_019212882.1 highly similar to uniprot|C5DM90 Lachancea thermotolerans KLTH0G06908g hypothetical protein; uncharacterized protein 421326 34685423 LALA0_S04e04984g Lachancea lanzarotensis uncharacterized protein XP_022628209.1 420118 R 1245769 CDS LALA0_S04e05006g 34685424 complement(421802..422392) Unknown 1 NW_019212882.1 similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4; TRAPP subunit TRS23 422392 34685424 LALA0_S04e05006g Lachancea lanzarotensis TRAPP subunit TRS23 XP_022628210.1 421802 R 1245769 CDS LALA0_S04e05028g 34685425 422549..423223 Unknown 1 NW_019212882.1 similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase; uncharacterized protein 423223 34685425 LALA0_S04e05028g Lachancea lanzarotensis uncharacterized protein XP_022628211.1 422549 D 1245769 CDS LALA0_S04e05050g 34685426 complement(423342..425267) Unknown 1 NW_019212882.1 similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) MET12 425267 34685426 LALA0_S04e05050g Lachancea lanzarotensis methylenetetrahydrofolate reductase (NAD(P)H) MET12 XP_022628212.1 423342 R 1245769 CDS LALA0_S04e05072g 34685427 426244..426954 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity; uncharacterized protein 426954 34685427 LALA0_S04e05072g Lachancea lanzarotensis uncharacterized protein XP_022628213.1 426244 D 1245769 CDS LALA0_S04e05094g 34685428 complement(427094..428431) Unknown 1 NW_019212882.1 highly similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels; prephenate dehydrogenase (NADP(+)) 428431 34685428 LALA0_S04e05094g Lachancea lanzarotensis prephenate dehydrogenase (NADP(+)) XP_022628214.1 427094 R 1245769 CDS LALA0_S04e05116g 34685429 429203..429820 Unknown 1 NW_019212882.1 similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression; ureidoglycolate hydrolase 429820 34685429 LALA0_S04e05116g Lachancea lanzarotensis ureidoglycolate hydrolase XP_022628215.1 429203 D 1245769 CDS LALA0_S04e05138g 34685430 430143..430691 Unknown 1 NW_019212882.1 similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; uncharacterized protein 430691 34685430 LALA0_S04e05138g Lachancea lanzarotensis uncharacterized protein XP_022628216.1 430143 D 1245769 CDS LALA0_S04e05160g 34685431 complement(430769..431179) Unknown 1 NW_019212882.1 similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; ribonuclease P/MRP protein subunit POP7 431179 34685431 LALA0_S04e05160g Lachancea lanzarotensis ribonuclease P/MRP protein subunit POP7 XP_022628217.1 430769 R 1245769 CDS LALA0_S04e05182g 34685432 431375..432547 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; uncharacterized protein 432547 34685432 LALA0_S04e05182g Lachancea lanzarotensis uncharacterized protein XP_022628218.1 431375 D 1245769 CDS LALA0_S04e05204g 34685433 433037..433717 Unknown 1 NW_019212882.1 similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene; uncharacterized protein 433717 34685433 LALA0_S04e05204g Lachancea lanzarotensis uncharacterized protein XP_022628219.1 433037 D 1245769 CDS LALA0_S04e05226g 34685434 complement(433919..436006) Unknown 1 NW_019212882.1 highly similar to uniprot|P32590 Saccharomyces cerevisiae YBR169C (ohnolog of YPL106C) SSE2 Member of theheat shock protein 70 (HSP70) family; may be involved inprotein folding; localized to the cytoplasm; highlyhomologous to the heat shock protein Sse1p; adenyl-nucleotide exchange factor SSE2 436006 34685434 LALA0_S04e05226g Lachancea lanzarotensis adenyl-nucleotide exchange factor SSE2 XP_022628220.1 433919 R 1245769 CDS LALA0_S04e05248g 34685435 complement(436522..438270) Unknown 1 NW_019212882.1 similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD); nuclear protein localization protein 4 438270 34685435 LALA0_S04e05248g Lachancea lanzarotensis nuclear protein localization protein 4 XP_022628221.1 436522 R 1245769 CDS LALA0_S04e05270g 34685436 complement(438753..441326) Unknown 1 NW_019212882.1 weakly similar to uniprot|P37898 Saccharomyces cerevisiae YHR047C (ohnolog of YKL157W) AAP1 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation; uncharacterized protein 441326 34685436 LALA0_S04e05270g Lachancea lanzarotensis uncharacterized protein XP_022628222.1 438753 R 1245769 CDS LALA0_S04e05292g 34685437 442089..442706 Unknown 1 NW_019212882.1 similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; Sec63 complex subunit SEC66 442706 34685437 LALA0_S04e05292g Lachancea lanzarotensis Sec63 complex subunit SEC66 XP_022628223.1 442089 D 1245769 CDS LALA0_S04e05314g 34685438 complement(442882..445275) Unknown 1 NW_019212882.1 weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C (ohnolog of YPL105C) SMY2 Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2; uncharacterized protein 445275 34685438 LALA0_S04e05314g Lachancea lanzarotensis uncharacterized protein XP_022628224.1 442882 R 1245769 CDS LALA0_S04e05336g 34685439 complement(445745..446200) Unknown 1 NW_019212882.1 similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly; uncharacterized protein 446200 34685439 LALA0_S04e05336g Lachancea lanzarotensis uncharacterized protein XP_022628225.1 445745 R 1245769 CDS LALA0_S04e05358g 34685440 446621..447583 Unknown 1 NW_019212882.1 similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5; uncharacterized protein 447583 34685440 LALA0_S04e05358g Lachancea lanzarotensis uncharacterized protein XP_022628226.1 446621 D 1245769 CDS LALA0_S04e05380g 34685441 447771..449723 Unknown 1 NW_019212882.1 similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W MSD1 Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene; aspartate--tRNA ligase MSD1 449723 34685441 LALA0_S04e05380g Lachancea lanzarotensis aspartate--tRNA ligase MSD1 XP_022628227.1 447771 D 1245769 CDS LALA0_S04e05402g 34685442 complement(450049..451374) Unknown 1 NW_019212882.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; uncharacterized protein 451374 34685442 LALA0_S04e05402g Lachancea lanzarotensis uncharacterized protein XP_022628228.1 450049 R 1245769 CDS LALA0_S04e05424g 34685443 452395..455847 Unknown 1 NW_019212882.1 weakly similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization; DNA-binding transcription factor ADR1 455847 34685443 LALA0_S04e05424g Lachancea lanzarotensis DNA-binding transcription factor ADR1 XP_022628229.1 452395 D 1245769 CDS LALA0_S04e05446g 34685444 complement(455908..459207) Unknown 1 NW_019212882.1 weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate; chromatin-binding protein RAD9 459207 34685444 LALA0_S04e05446g Lachancea lanzarotensis chromatin-binding protein RAD9 XP_022628230.1 455908 R 1245769 CDS LALA0_S04e05468g 34685445 join(459335..459344,459482..460884) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; uncharacterized protein 460884 34685445 LALA0_S04e05468g Lachancea lanzarotensis uncharacterized protein XP_022628231.1 459335 D 1245769 CDS LALA0_S04e05490g 34685446 complement(461122..462273) Unknown 1 NW_019212882.1 similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II; uncharacterized protein 462273 34685446 LALA0_S04e05490g Lachancea lanzarotensis uncharacterized protein XP_022628232.1 461122 R 1245769 CDS LALA0_S04e05512g 34685447 complement(462541..463821) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q04922 Saccharomyces cerevisiae YDR219C MFB1 Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding; uncharacterized protein 463821 34685447 LALA0_S04e05512g Lachancea lanzarotensis uncharacterized protein XP_022628233.1 462541 R 1245769 CDS LALA0_S04e05534g 34685448 464821..466818 Unknown 1 NW_019212882.1 similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W GTB1 Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; uncharacterized protein 466818 34685448 LALA0_S04e05534g Lachancea lanzarotensis uncharacterized protein XP_022628234.1 464821 D 1245769 CDS LALA0_S04e05556g 34685449 468202..471144 Unknown 1 NW_019212882.1 similar to uniprot|Q04930 Saccharomyces cerevisiae YDR223W (ohnolog of YLR223C) CRF1 Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; uncharacterized protein 471144 34685449 LALA0_S04e05556g Lachancea lanzarotensis uncharacterized protein XP_022628235.1 468202 D 1245769 CDS LALA0_S04e05578g 34685450 471771..474260 Unknown 1 NW_019212882.1 highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 474260 34685450 LALA0_S04e05578g Lachancea lanzarotensis uncharacterized protein XP_022628236.1 471771 D 1245769 CDS LALA0_S04e05600g 34685451 474451..475059 Unknown 1 NW_019212882.1 similar to uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus; uncharacterized protein 475059 34685451 LALA0_S04e05600g Lachancea lanzarotensis uncharacterized protein XP_022628237.1 474451 D 1245769 CDS LALA0_S04e05622g 34685452 complement(475308..476213) Unknown 1 NW_019212882.1 similar to uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; uncharacterized protein 476213 34685452 LALA0_S04e05622g Lachancea lanzarotensis uncharacterized protein XP_022628238.1 475308 R 1245769 CDS LALA0_S04e05644g 34685453 complement(477852..478250) Unknown 1 NW_019212882.1 highly similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; histone H2B 478250 34685453 LALA0_S04e05644g Lachancea lanzarotensis histone H2B XP_022628239.1 477852 R 1245769 CDS LALA0_S04e05666g 34685454 478905..479300 Unknown 1 NW_019212882.1 highly similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; histone H2A 479300 34685454 LALA0_S04e05666g Lachancea lanzarotensis histone H2A XP_022628240.1 478905 D 1245769 CDS LALA0_S04e05688g 34685455 complement(479495..481594) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; uncharacterized protein 481594 34685455 LALA0_S04e05688g Lachancea lanzarotensis uncharacterized protein XP_022628241.1 479495 R 1245769 CDS LALA0_S04e05754g 34685458 487958..488641 Unknown 1 NW_019212882.1 highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; adenylate kinase ADK1 488641 34685458 LALA0_S04e05754g Lachancea lanzarotensis adenylate kinase ADK1 XP_022628242.1 487958 D 1245769 CDS LALA0_S04e05776g 34685459 489004..494046 Unknown 1 NW_019212882.1 weakly similar to uniprot|P11978 Saccharomyces cerevisiae YDR227W SIR4 Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan; uncharacterized protein 494046 34685459 LALA0_S04e05776g Lachancea lanzarotensis uncharacterized protein XP_022628243.1 489004 D 1245769 CDS LALA0_S04e05798g 34685460 complement(494271..496001) Unknown 1 NW_019212882.1 similar to uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; uncharacterized protein 496001 34685460 LALA0_S04e05798g Lachancea lanzarotensis uncharacterized protein XP_022628244.1 494271 R 1245769 CDS LALA0_S04e05820g 34685461 497687..498583 Unknown 1 NW_019212882.1 highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; uncharacterized protein 498583 34685461 LALA0_S04e05820g Lachancea lanzarotensis uncharacterized protein XP_022628245.1 497687 D 1245769 CDS LALA0_S04e05842g 34685462 complement(498891..499865) Unknown 1 NW_019212882.1 weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; uncharacterized protein 499865 34685462 LALA0_S04e05842g Lachancea lanzarotensis uncharacterized protein XP_022628246.1 498891 R 1245769 CDS LALA0_S04e05864g 34685463 504534..506714 Unknown 1 NW_019212882.1 weakly similar to uniprot|Q12407 Saccharomyces cerevisiae YDL199C Putative transporter, member of the sugar porter family; uncharacterized protein 506714 34685463 LALA0_S04e05864g Lachancea lanzarotensis uncharacterized protein XP_022628247.1 504534 D 1245769 CDS LALA0_S04e05886g 34685464 complement(506832..507683) Unknown 1 NW_019212882.1 highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA; tRNA (guanine46-N7)-methyltransferase 507683 34685464 LALA0_S04e05886g Lachancea lanzarotensis tRNA (guanine46-N7)-methyltransferase XP_022628248.1 506832 R 1245769 CDS LALA0_S04e05908g 34685465 complement(508039..508722) Unknown 1 NW_019212882.1 similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL10m 508722 34685465 LALA0_S04e05908g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL10m XP_022628249.1 508039 R 1245769 CDS LALA0_S04e05930g 34685466 509815..511110 Unknown 1 NW_019212882.1 similar to uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; uncharacterized protein 511110 34685466 LALA0_S04e05930g Lachancea lanzarotensis uncharacterized protein XP_022628250.1 509815 D 1245769 CDS LALA0_S04e05952g 34685467 complement(511221..511775) Unknown 1 NW_019212882.1 similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; uncharacterized protein 511775 34685467 LALA0_S04e05952g Lachancea lanzarotensis uncharacterized protein XP_022628251.1 511221 R 1245769 CDS LALA0_S04e05974g 34685468 512649..514478 Unknown 1 NW_019212882.1 similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C ACK1 Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria; uncharacterized protein 514478 34685468 LALA0_S04e05974g Lachancea lanzarotensis uncharacterized protein XP_022628252.1 512649 D 1245769 CDS LALA0_S04e05996g 34685469 514894..516585 Unknown 1 NW_019212882.1 highly similar to uniprot|P09950 Saccharomyces cerevisiae YDR232W HEM1 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; 5-aminolevulinate synthase 516585 34685469 LALA0_S04e05996g Lachancea lanzarotensis 5-aminolevulinate synthase XP_022628253.1 514894 D 1245769 CDS LALA0_S04e06018g 34685470 complement(517182..517994) Unknown 1 NW_019212882.1 similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C (ohnolog of YDL204W) RTN1 ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily; uncharacterized protein 517994 34685470 LALA0_S04e06018g Lachancea lanzarotensis uncharacterized protein XP_022628254.1 517182 R 1245769 CDS LALA0_S04e06040g 34685471 520177..522237 Unknown 1 NW_019212882.1 highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; homoaconitate hydratase LYS4 522237 34685471 LALA0_S04e06040g Lachancea lanzarotensis homoaconitate hydratase LYS4 XP_022628255.1 520177 D 1245769 CDS LALA0_S04e06062g 34685472 523537..524529 Unknown 1 NW_019212882.1 similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; hydroxymethylbilane synthase 524529 34685472 LALA0_S04e06062g Lachancea lanzarotensis hydroxymethylbilane synthase XP_022628256.1 523537 D 1245769 CDS LALA0_S04e06084g 34685473 524970..526562 Unknown 1 NW_019212882.1 similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats; mRNA splicing protein PRP42 526562 34685473 LALA0_S04e06084g Lachancea lanzarotensis mRNA splicing protein PRP42 XP_022628257.1 524970 D 1245769 CDS LALA0_S04e06106g 34685474 complement(526559..528547) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q12424 Saccharomyces cerevisiae YDL206W Putative protein of unknown function; YDL206W is not an essential protein; uncharacterized protein 528547 34685474 LALA0_S04e06106g Lachancea lanzarotensis uncharacterized protein XP_022628258.1 526559 R 1245769 CDS LALA0_S04e06128g 34685475 complement(528666..529211) Unknown 1 NW_019212882.1 similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane; riboflavin kinase 529211 34685475 LALA0_S04e06128g Lachancea lanzarotensis riboflavin kinase XP_022628259.1 528666 R 1245769 CDS LALA0_S04e06150g 34685476 complement(530953..532566) Unknown 1 NW_019212882.1 similar to uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the ATPase activities of Dbp1p and Dbp5p at the nuclear pore complex during mRNA export; nucleoporin GLE1 532566 34685476 LALA0_S04e06150g Lachancea lanzarotensis nucleoporin GLE1 XP_022628260.1 530953 R 1245769 CDS LALA0_S04e06172g 34685477 532875..533747 Unknown 1 NW_019212882.1 highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL5m 533747 34685477 LALA0_S04e06172g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL5m XP_022628261.1 532875 D 1245769 CDS LALA0_S04e06194g 34685478 complement(533855..536770) Unknown 1 NW_019212882.1 highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP); coatomer subunit beta 536770 34685478 LALA0_S04e06194g Lachancea lanzarotensis coatomer subunit beta XP_022628262.1 533855 R 1245769 CDS LALA0_S04e06216g 34685479 complement(537557..539665) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; uncharacterized protein 539665 34685479 LALA0_S04e06216g Lachancea lanzarotensis uncharacterized protein XP_022628263.1 537557 R 1245769 CDS LALA0_S04e06238g 34685480 complement(539802..541181) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex; uncharacterized protein 541181 34685480 LALA0_S04e06238g Lachancea lanzarotensis uncharacterized protein XP_022628264.1 539802 R 1245769 CDS LALA0_S04e06260g 34685481 complement(541511..541960) Unknown 1 NW_019212882.1 highly similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing; snoRNA-binding protein NHP2 541960 34685481 LALA0_S04e06260g Lachancea lanzarotensis snoRNA-binding protein NHP2 XP_022628265.1 541511 R 1245769 CDS LALA0_S04e06304g 34685483 543199..544947 Unknown 1 NW_019212882.1 similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; divalent metal ion transporter SMF2 544947 34685483 LALA0_S04e06304g Lachancea lanzarotensis divalent metal ion transporter SMF2 XP_022628266.1 543199 D 1245769 CDS LALA0_S04e06326g 34685484 545157..545834 Unknown 1 NW_019212882.1 similar to uniprot|P36054 Saccharomyces cerevisiae YKL159C RCN1 Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region; uncharacterized protein 545834 34685484 LALA0_S04e06326g Lachancea lanzarotensis uncharacterized protein XP_022628267.1 545157 D 1245769 CDS LALA0_S04e06348g 34685485 546224..546673 Unknown 1 NW_019212882.1 highly similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels; cytochrome c oxidase subunit VI 546673 34685485 LALA0_S04e06348g Lachancea lanzarotensis cytochrome c oxidase subunit VI XP_022628268.1 546224 D 1245769 CDS LALA0_S04e06370g 34685486 complement(546936..547394) Unknown 1 NW_019212882.1 similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression; uncharacterized protein 547394 34685486 LALA0_S04e06370g Lachancea lanzarotensis uncharacterized protein XP_022628269.1 546936 R 1245769 CDS LALA0_S04e06392g 34685487 548553..549806 Unknown 1 NW_019212882.1 similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles; uncharacterized protein 549806 34685487 LALA0_S04e06392g Lachancea lanzarotensis uncharacterized protein XP_022628270.1 548553 D 1245769 CDS LALA0_S04e06414g 34685488 550362..551390 Unknown 1 NW_019212882.1 similar to uniprot|C5DMA1 Lachancea thermotolerans KLTH0G07150g hypothetical protein; uncharacterized protein 551390 34685488 LALA0_S04e06414g Lachancea lanzarotensis uncharacterized protein XP_022628271.1 550362 D 1245769 CDS LALA0_S04e06436g 34685489 complement(551511..553376) Unknown 1 NW_019212882.1 similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W ERC1 Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine; uncharacterized protein 553376 34685489 LALA0_S04e06436g Lachancea lanzarotensis uncharacterized protein XP_022628272.1 551511 R 1245769 CDS LALA0_S04e06458g 34685490 554041..556083 Unknown 1 NW_019212882.1 similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p; DNA helicase 556083 34685490 LALA0_S04e06458g Lachancea lanzarotensis DNA helicase XP_022628273.1 554041 D 1245769 CDS LALA0_S04e06480g 34685491 556780..558357 Unknown 1 NW_019212882.1 highly similar to uniprot|Q00772 Saccharomyces cerevisiae YHR030C (ohnolog of YKL161C) SLT2 Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway; mitogen-activated serine/threonine-protein kinase SLT2 558357 34685491 LALA0_S04e06480g Lachancea lanzarotensis mitogen-activated serine/threonine-protein kinase SLT2 XP_022628274.1 556780 D 1245769 CDS LALA0_S04e06502g 34685492 558837..561302 Unknown 1 NW_019212882.1 similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C DAP2 Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p; dipeptidyl aminopeptidase 561302 34685492 LALA0_S04e06502g Lachancea lanzarotensis dipeptidyl aminopeptidase XP_022628275.1 558837 D 1245769 CDS LALA0_S04e06524g 34685493 561765..564695 Unknown 1 NW_019212882.1 highly similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; proteasome regulatory particle base subunit RPN1 564695 34685493 LALA0_S04e06524g Lachancea lanzarotensis proteasome regulatory particle base subunit RPN1 XP_022628276.1 561765 D 1245769 CDS LALA0_S04e06546g 34685494 complement(564957..565595) Unknown 1 NW_019212882.1 highly similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W VMA16 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain; H(+)-transporting V0 sector ATPase subunit c'' 565595 34685494 LALA0_S04e06546g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit c'' XP_022628277.1 564957 R 1245769 CDS LALA0_S04e06568g 34685495 567559..568569 Unknown 1 NW_019212882.1 similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 568569 34685495 LALA0_S04e06568g Lachancea lanzarotensis uncharacterized protein XP_022628278.1 567559 D 1245769 CDS LALA0_S04e06590g 34685496 complement(569025..570128) Unknown 1 NW_019212882.1 highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway; homoserine kinase 570128 34685496 LALA0_S04e06590g Lachancea lanzarotensis homoserine kinase XP_022628279.1 569025 R 1245769 CDS LALA0_S04e06612g 34685497 571570..573045 Unknown 1 NW_019212882.1 highly similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; mitochondrial-processing protease subunit alpha 573045 34685497 LALA0_S04e06612g Lachancea lanzarotensis mitochondrial-processing protease subunit alpha XP_022628280.1 571570 D 1245769 CDS LALA0_S04e06634g 34685498 complement(573118..578697) Unknown 1 NW_019212882.1 similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; myosin 1 578697 34685498 LALA0_S04e06634g Lachancea lanzarotensis myosin 1 XP_022628281.1 573118 R 1245769 CDS LALA0_S04e06656g 34685499 579943..581814 Unknown 1 NW_019212882.1 similar to Lachancea thermotolerans KLTH0G07172g hypothetical protein; uncharacterized protein 581814 34685499 LALA0_S04e06656g Lachancea lanzarotensis uncharacterized protein XP_022628282.1 579943 D 1245769 CDS LALA0_S04e06678g 34685500 582707..583870 Unknown 1 NW_019212882.1 similar to uniprot|C5DMF8 Lachancea thermotolerans KLTH0G08536g hypothetical protein; uncharacterized protein 583870 34685500 LALA0_S04e06678g Lachancea lanzarotensis uncharacterized protein XP_022628283.1 582707 D 1245769 CDS LALA0_S04e06700g 34685501 join(585042..585044,585511..585756) Unknown 1 NW_019212882.1 highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021C (ohnolog of YKL156W) RPS27B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein; 40S ribosomal protein eS27 585756 34685501 LALA0_S04e06700g Lachancea lanzarotensis 40S ribosomal protein eS27 XP_022628284.1 585042 D 1245769 CDS LALA0_S04e06722g 34685502 complement(586216..588276) Unknown 1 NW_019212882.1 similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase; tRNA methyltransferase RSM22 588276 34685502 LALA0_S04e06722g Lachancea lanzarotensis tRNA methyltransferase RSM22 XP_022628285.1 586216 R 1245769 CDS LALA0_S04e06744g 34685503 join(588531..588716,588788..589384) Unknown 1 NW_019212882.1 similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane; Signal recognition particle receptor subunit beta 589384 34685503 LALA0_S04e06744g Lachancea lanzarotensis Signal recognition particle receptor subunit beta XP_022628286.1 588531 D 1245769 CDS LALA0_S04e06766g 34685504 complement(589413..589640) Unknown 1 NW_019212882.1 similar to uniprot|Q2V2P5 Saccharomyces cerevisiae YIL102C-A Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species; uncharacterized protein 589640 34685504 LALA0_S04e06766g Lachancea lanzarotensis uncharacterized protein XP_022628287.1 589413 R 1245769 CDS LALA0_S04e06810g 34685506 590529..595490 Unknown 1 NW_019212882.1 similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205; uncharacterized protein 595490 34685506 LALA0_S04e06810g Lachancea lanzarotensis uncharacterized protein XP_022628288.1 590529 D 1245769 CDS LALA0_S04e06832g 34685507 complement(join(595576..597914,597989)) Unknown 1 NW_019212882.1 weakly similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes; FG-nucleoporin NSP1 597989 34685507 LALA0_S04e06832g Lachancea lanzarotensis FG-nucleoporin NSP1 XP_022628289.1 595576 R 1245769 CDS LALA0_S04e06854g 34685508 complement(598217..602278) Unknown 1 NW_019212882.1 similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins; uncharacterized protein 602278 34685508 LALA0_S04e06854g Lachancea lanzarotensis uncharacterized protein XP_022628290.1 598217 R 1245769 CDS LALA0_S04e06876g 34685509 603138..604289 Unknown 1 NW_019212882.1 similar to uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport; GTPase-activating protein GYP6 604289 34685509 LALA0_S04e06876g Lachancea lanzarotensis GTPase-activating protein GYP6 XP_022628291.1 603138 D 1245769 CDS LALA0_S04e06898g 34685510 complement(604440..605186) Unknown 1 NW_019212882.1 highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; phosphoglycerate mutase GPM1 605186 34685510 LALA0_S04e06898g Lachancea lanzarotensis phosphoglycerate mutase GPM1 XP_022628292.1 604440 R 1245769 CDS LALA0_S04e06920g 34685511 complement(606239..607195) Unknown 1 NW_019212882.1 similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; NADHX dehydratase 607195 34685511 LALA0_S04e06920g Lachancea lanzarotensis NADHX dehydratase XP_022628293.1 606239 R 1245769 CDS LALA0_S04e06942g 34685512 608020..608898 Unknown 1 NW_019212882.1 similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis; cytochrome-b5 reductase 608898 34685512 LALA0_S04e06942g Lachancea lanzarotensis cytochrome-b5 reductase XP_022628294.1 608020 D 1245769 CDS LALA0_S04e06964g 34685513 complement(608977..610062) Unknown 1 NW_019212882.1 similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition; RNA lariat debranching enzyme 610062 34685513 LALA0_S04e06964g Lachancea lanzarotensis RNA lariat debranching enzyme XP_022628295.1 608977 R 1245769 CDS LALA0_S04e06986g 34685514 complement(610257..612173) Unknown 1 NW_019212882.1 highly similar to uniprot|P47052 Saccharomyces cerevisiae YJL045W (ohnolog of YKL148C) Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; succinate dehydrogenase flavoprotein subunit SDH1 612173 34685514 LALA0_S04e06986g Lachancea lanzarotensis succinate dehydrogenase flavoprotein subunit SDH1 XP_022628296.1 610257 R 1245769 CDS LALA0_S04e07008g 34685515 complement(613197..614330) Unknown 1 NW_019212882.1 weakly similar to uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 614330 34685515 LALA0_S04e07008g Lachancea lanzarotensis uncharacterized protein XP_022628297.1 613197 R 1245769 CDS LALA0_S04e07030g 34685516 complement(615746..617557) Unknown 1 NW_019212882.1 similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 617557 34685516 LALA0_S04e07030g Lachancea lanzarotensis uncharacterized protein XP_022628298.1 615746 R 1245769 CDS LALA0_S04e07052g 34685517 join(619357..619470,619729..620952) Unknown 1 NW_019212882.1 highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance; proteasome regulatory particle base subunit RPT1 620952 34685517 LALA0_S04e07052g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT1 XP_022628299.1 619357 D 1245769 CDS LALA0_S04e07074g 34685518 complement(621124..621759) Unknown 1 NW_019212882.1 highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p; DNA-directed RNA polymerase III subunit RPC25 621759 34685518 LALA0_S04e07074g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit RPC25 XP_022628300.1 621124 R 1245769 CDS LALA0_S04e07096g 34685519 622274..623728 Unknown 1 NW_019212882.1 similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature; uncharacterized protein 623728 34685519 LALA0_S04e07096g Lachancea lanzarotensis uncharacterized protein XP_022628301.1 622274 D 1245769 CDS LALA0_S04e07118g 34685520 624057..624719 Unknown 1 NW_019212882.1 similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W MRP8 Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis; uncharacterized protein 624719 34685520 LALA0_S04e07118g Lachancea lanzarotensis uncharacterized protein XP_022628302.1 624057 D 1245769 CDS LALA0_S04e07140g 34685521 complement(624826..626832) Unknown 1 NW_019212882.1 similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C NOP9 Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain; RNA-binding RNA processing protein NOP9 626832 34685521 LALA0_S04e07140g Lachancea lanzarotensis RNA-binding RNA processing protein NOP9 XP_022628303.1 624826 R 1245769 CDS LALA0_S04e07162g 34685522 complement(627066..628742) Unknown 1 NW_019212882.1 highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT8 628742 34685522 LALA0_S04e07162g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT8 XP_022628304.1 627066 R 1245769 CDS LALA0_S04e07206g 34685524 629646..632072 Unknown 1 NW_019212882.1 similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting; uncharacterized protein 632072 34685524 LALA0_S04e07206g Lachancea lanzarotensis uncharacterized protein XP_022628305.1 629646 D 1245769 CDS LALA0_S04e07228g 34685525 complement(632112..632741) Unknown 1 NW_019212882.1 similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; spindle checkpoint protein MAD2 632741 34685525 LALA0_S04e07228g Lachancea lanzarotensis spindle checkpoint protein MAD2 XP_022628306.1 632112 R 1245769 CDS LALA0_S04e07250g 34685526 join(633721..633723,633793..634770) Unknown 1 NW_019212882.1 similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; Rab geranylgeranyltransferase BET4 634770 34685526 LALA0_S04e07250g Lachancea lanzarotensis Rab geranylgeranyltransferase BET4 XP_022628307.1 633721 D 1245769 CDS LALA0_S04e07272g 34685527 complement(634860..635831) Unknown 1 NW_019212882.1 similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C CTK2 Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; uncharacterized protein 635831 34685527 LALA0_S04e07272g Lachancea lanzarotensis uncharacterized protein XP_022628308.1 634860 R 1245769 CDS LALA0_S04e07294g 34685528 complement(636311..638662) Unknown 1 NW_019212882.1 highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; RNA-dependent ATPase HCA4 638662 34685528 LALA0_S04e07294g Lachancea lanzarotensis RNA-dependent ATPase HCA4 XP_022628309.1 636311 R 1245769 CDS LALA0_S04e07316g 34685529 639365..640015 Unknown 1 NW_019212882.1 similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C PML1 Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p; uncharacterized protein 640015 34685529 LALA0_S04e07316g Lachancea lanzarotensis uncharacterized protein XP_022628310.1 639365 D 1245769 CDS LALA0_S04e07338g 34685530 complement(640219..642267) Unknown 1 NW_019212882.1 highly similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p; Hsp70 family ATPase KAR2 642267 34685530 LALA0_S04e07338g Lachancea lanzarotensis Hsp70 family ATPase KAR2 XP_022628311.1 640219 R 1245769 CDS LALA0_S04e07360g 34685531 643370..644122 Unknown 1 NW_019212882.1 similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs; tRNA(adenine34) deaminase 644122 34685531 LALA0_S04e07360g Lachancea lanzarotensis tRNA(adenine34) deaminase XP_022628312.1 643370 D 1245769 CDS LALA0_S04e07382g 34685532 complement(644178..645449) Unknown 1 NW_019212882.1 similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p; uncharacterized protein 645449 34685532 LALA0_S04e07382g Lachancea lanzarotensis uncharacterized protein XP_022628313.1 644178 R 1245769 CDS LALA0_S04e07404g 34685533 complement(646268..647656) Unknown 1 NW_019212882.1 similar to uniprot|P43132 Saccharomyces cerevisiae YLR015W BRE2 Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L; uncharacterized protein 647656 34685533 LALA0_S04e07404g Lachancea lanzarotensis uncharacterized protein XP_022628314.1 646268 R 1245769 CDS LALA0_S04e07426g 34685534 649191..651905 Unknown 1 NW_019212882.1 similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p; uncharacterized protein 651905 34685534 LALA0_S04e07426g Lachancea lanzarotensis uncharacterized protein XP_022628315.1 649191 D 1245769 CDS LALA0_S04e07470g 34685536 652671..653648 Unknown 1 NW_019212882.1 similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; carnitine:acyl carnitine antiporter 653648 34685536 LALA0_S04e07470g Lachancea lanzarotensis carnitine:acyl carnitine antiporter XP_022628316.1 652671 D 1245769 CDS LALA0_S04e07492g 34685537 complement(653744..654919) Unknown 1 NW_019212882.1 similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1,2-mannosyltransferase involved in O-and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; alpha-1,2-mannosyltransferase KTR1 654919 34685537 LALA0_S04e07492g Lachancea lanzarotensis alpha-1,2-mannosyltransferase KTR1 XP_022628317.1 653744 R 1245769 CDS LALA0_S04e07514g 34685538 656132..658771 Unknown 1 NW_019212882.1 weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate; FG-nucleoporin NUP1 658771 34685538 LALA0_S04e07514g Lachancea lanzarotensis FG-nucleoporin NUP1 XP_022628318.1 656132 D 1245769 CDS LALA0_S04e07536g 34685539 complement(658871..660676) Unknown 1 NW_019212882.1 weakly similar to uniprot|P53059 Saccharomyces cerevisiae YGL257C MNT2 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans; uncharacterized protein 660676 34685539 LALA0_S04e07536g Lachancea lanzarotensis uncharacterized protein XP_022628319.1 658871 R 1245769 CDS LALA0_S04e07558g 34685540 662203..662667 Unknown 1 NW_019212882.1 weakly similar to uniprot|Q12274 Saccharomyces cerevisiae YOR097C Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene; uncharacterized protein 662667 34685540 LALA0_S04e07558g Lachancea lanzarotensis uncharacterized protein XP_022628320.1 662203 D 1245769 CDS LALA0_S04e07580g 34685541 complement(join(662839..663267,663466..663606)) Unknown 1 NW_019212882.1 highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W (ohnolog of YNL096C) RPS7A Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins; 40S ribosomal protein eS7 663606 34685541 LALA0_S04e07580g Lachancea lanzarotensis 40S ribosomal protein eS7 XP_022628321.1 662839 R 1245769 CDS LALA0_S04e07602g 34685542 664928..665764 Unknown 1 NW_019212882.1 similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis; ribose-5-phosphate isomerase RKI1 665764 34685542 LALA0_S04e07602g Lachancea lanzarotensis ribose-5-phosphate isomerase RKI1 XP_022628322.1 664928 D 1245769 CDS LALA0_S04e07624g 34685543 complement(666081..666635) Unknown 1 NW_019212882.1 highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity; Arf family GTPase ARF3 666635 34685543 LALA0_S04e07624g Lachancea lanzarotensis Arf family GTPase ARF3 XP_022628323.1 666081 R 1245769 CDS LALA0_S04e07646g 34685544 667705..672558 Unknown 1 NW_019212882.1 similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents; uncharacterized protein 672558 34685544 LALA0_S04e07646g Lachancea lanzarotensis uncharacterized protein XP_022628324.1 667705 D 1245769 CDS LALA0_S04e07668g 34685545 672907..674529 Unknown 1 NW_019212882.1 similar to uniprot|Q99252 Saccharomyces cerevisiae YOR092W (ohnolog of YNL095C) ECM3 Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; uncharacterized protein 674529 34685545 LALA0_S04e07668g Lachancea lanzarotensis uncharacterized protein XP_022628325.1 672907 D 1245769 CDS LALA0_S04e07690g 34685546 675297..677045 Unknown 1 NW_019212882.1 similar to uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization; phosphatidate phosphatase APP1 677045 34685546 LALA0_S04e07690g Lachancea lanzarotensis phosphatidate phosphatase APP1 XP_022628326.1 675297 D 1245769 CDS LALA0_S04e07712g 34685547 complement(677237..678265) Unknown 1 NW_019212882.1 highly similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W TMA46 Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p; uncharacterized protein 678265 34685547 LALA0_S04e07712g Lachancea lanzarotensis uncharacterized protein XP_022628327.1 677237 R 1245769 CDS LALA0_S04e07734g 34685548 678566..679981 Unknown 1 NW_019212882.1 similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p; type 2C protein phosphatase PTC5 679981 34685548 LALA0_S04e07734g Lachancea lanzarotensis type 2C protein phosphatase PTC5 XP_022628328.1 678566 D 1245769 CDS LALA0_S04e07756g 34685549 680606..681250 Unknown 1 NW_019212882.1 highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C (ohnolog of YNL093W) VPS21 Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; uncharacterized protein 681250 34685549 LALA0_S04e07756g Lachancea lanzarotensis uncharacterized protein XP_022628329.1 680606 D 1245769 CDS LALA0_S04e07778g 34685550 complement(681371..683398) Unknown 1 NW_019212882.1 similar to uniprot|Q12324 Saccharomyces cerevisiae YOR087W YVC1 Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock; uncharacterized protein 683398 34685550 LALA0_S04e07778g Lachancea lanzarotensis uncharacterized protein XP_022628330.1 681371 R 1245769 CDS LALA0_S04e07800g 34685551 684494..688198 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; uncharacterized protein 688198 34685551 LALA0_S04e07800g Lachancea lanzarotensis uncharacterized protein XP_022628331.1 684494 D 1245769 CDS LALA0_S04e07822g 34685552 688630..689193 Unknown 1 NW_019212882.1 highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly; Rho family GTPase RHO2 689193 34685552 LALA0_S04e07822g Lachancea lanzarotensis Rho family GTPase RHO2 XP_022628332.1 688630 D 1245769 CDS LALA0_S04e07866g 34685554 689675..694066 Unknown 1 NW_019212882.1 similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; DNA topoisomerase 2 694066 34685554 LALA0_S04e07866g Lachancea lanzarotensis DNA topoisomerase 2 XP_022628333.1 689675 D 1245769 CDS LALA0_S04e07888g 34685555 694543..698058 Unknown 1 NW_019212882.1 similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C (ohnolog of YNL087W) TCB1 Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact; tricalbin 698058 34685555 LALA0_S04e07888g Lachancea lanzarotensis tricalbin XP_022628334.1 694543 D 1245769 CDS LALA0_S04e07910g 34685556 698204..698491 Unknown 1 NW_019212882.1 similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W SNN1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes; uncharacterized protein 698491 34685556 LALA0_S04e07910g Lachancea lanzarotensis uncharacterized protein XP_022628335.1 698204 D 1245769 CDS LALA0_S04e07932g 34685557 complement(698533..699585) Unknown 1 NW_019212882.1 similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 699585 34685557 LALA0_S04e07932g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 XP_022628336.1 698533 R 1245769 CDS LALA0_S04e07954g 34685558 700706..703105 Unknown 1 NW_019212882.1 similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; uncharacterized protein 703105 34685558 LALA0_S04e07954g Lachancea lanzarotensis uncharacterized protein XP_022628337.1 700706 D 1245769 CDS LALA0_S04e07998g 34685560 join(703863..703865,703984..705564) Unknown 1 NW_019212882.1 highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT2 705564 34685560 LALA0_S04e07998g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT2 XP_022628338.1 703863 D 1245769 CDS LALA0_S04e08020g 34685561 complement(705658..706779) Unknown 1 NW_019212882.1 similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p; uncharacterized protein 706779 34685561 LALA0_S04e08020g Lachancea lanzarotensis uncharacterized protein XP_022628339.1 705658 R 1245769 CDS LALA0_S04e08042g 34685562 707873..710362 Unknown 1 NW_019212882.1 similar to uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate; uncharacterized protein 710362 34685562 LALA0_S04e08042g Lachancea lanzarotensis uncharacterized protein XP_022628340.1 707873 D 1245769 CDS LALA0_S04e08064g 34685563 complement(710535..712139) Unknown 1 NW_019212882.1 highly similar to uniprot|C5DMF8 Lachancea thermotolerans KLTH0G08536g hypothetical protein; uncharacterized protein 712139 34685563 LALA0_S04e08064g Lachancea lanzarotensis uncharacterized protein XP_022628341.1 710535 R 1245769 CDS LALA0_S04e08108g 34685565 713228..714775 Unknown 1 NW_019212882.1 similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains; Ca(2+)-binding ATP:ADP antiporter SAL1 714775 34685565 LALA0_S04e08108g Lachancea lanzarotensis Ca(2+)-binding ATP:ADP antiporter SAL1 XP_022628342.1 713228 D 1245769 CDS LALA0_S04e08130g 34685566 complement(714848..715567) Unknown 1 NW_019212882.1 similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; uncharacterized protein 715567 34685566 LALA0_S04e08130g Lachancea lanzarotensis uncharacterized protein XP_022628343.1 714848 R 1245769 CDS LALA0_S04e08152g 34685567 716811..719516 Unknown 1 NW_019212882.1 similar to uniprot|P14242 Saccharomyces cerevisiae YNL082W PMS1 ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL; ATP-binding mismatch repair protein 719516 34685567 LALA0_S04e08152g Lachancea lanzarotensis ATP-binding mismatch repair protein XP_022628344.1 716811 D 1245769 CDS LALA0_S04e08174g 34685568 complement(719677..720114) Unknown 1 NW_019212882.1 highly similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2 Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; mitochondrial 37S ribosomal protein uS13m 720114 34685568 LALA0_S04e08174g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS13m XP_022628345.1 719677 R 1245769 CDS LALA0_S04e08196g 34685569 complement(720481..721575) Unknown 1 NW_019212882.1 similar to uniprot|P53938 Saccharomyces cerevisiae YNL080C EOS1 Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene; uncharacterized protein 721575 34685569 LALA0_S04e08196g Lachancea lanzarotensis uncharacterized protein XP_022628346.1 720481 R 1245769 CDS LALA0_S04e08218g 34685570 complement(join(722431..722898,723061..723078)) Unknown 1 NW_019212882.1 highly similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C (ohnolog of YNL079C) TPM2 Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; tropomyosin TPM1 723078 34685570 LALA0_S04e08218g Lachancea lanzarotensis tropomyosin TPM1 XP_022628347.1 722431 R 1245769 CDS LALA0_S04e08240g 34685571 723508..723969 Unknown 1 NW_019212882.1 hypothetical protein; uncharacterized protein 723969 34685571 LALA0_S04e08240g Lachancea lanzarotensis uncharacterized protein XP_022628348.1 723508 D 1245769 CDS LALA0_S04e08262g 34685572 complement(724182..725552) Unknown 1 NW_019212882.1 similar to uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 725552 34685572 LALA0_S04e08262g Lachancea lanzarotensis uncharacterized protein XP_022628349.1 724182 R 1245769 CDS LALA0_S04e08284g 34685573 725937..728690 Unknown 1 NW_019212882.1 similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C TMA108 Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease; uncharacterized protein 728690 34685573 LALA0_S04e08284g Lachancea lanzarotensis uncharacterized protein XP_022628350.1 725937 D 1245769 CDS LALA0_S04e08306g 34685574 complement(728753..729778) Unknown 1 NW_019212882.1 weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network; uncharacterized protein 729778 34685574 LALA0_S04e08306g Lachancea lanzarotensis uncharacterized protein XP_022628351.1 728753 R 1245769 CDS LALA0_S04e08328g 34685575 732425..734038 Unknown 1 NW_019212882.1 some similarities with uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane; uncharacterized protein 734038 34685575 LALA0_S04e08328g Lachancea lanzarotensis uncharacterized protein XP_022628352.1 732425 D 1245769 CDS LALA0_S04e08350g 34685576 734510..736252 Unknown 1 NW_019212882.1 weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling; uncharacterized protein 736252 34685576 LALA0_S04e08350g Lachancea lanzarotensis uncharacterized protein XP_022628353.1 734510 D 1245769 CDS LALA0_S04e08372g 34685577 736490..737341 Unknown 1 NW_019212882.1 highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; snoRNA-binding rRNA-processing protein IMP4 737341 34685577 LALA0_S04e08372g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein IMP4 XP_022628354.1 736490 D 1245769 CDS LALA0_S04e08394g 34685578 complement(737699..738943) Unknown 1 NW_019212882.1 weakly similar to uniprot|P40463 Saccharomyces cerevisiae YIL135C (ohnolog of YNL074C) VHS2 Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p; uncharacterized protein 738943 34685578 LALA0_S04e08394g Lachancea lanzarotensis uncharacterized protein XP_022628355.1 737699 R 1245769 CDS LALA0_S04e08438g 34685580 746857..748443 Unknown 1 NW_019212882.1 similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys); lysine--tRNA ligase MSK1 748443 34685580 LALA0_S04e08438g Lachancea lanzarotensis lysine--tRNA ligase MSK1 XP_022628356.1 746857 D 1245769 CDS LALA0_S04e08460g 34685581 748695..749630 Unknown 1 NW_019212882.1 similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome; ribonuclease H2 catalytic subunit RNH201 749630 34685581 LALA0_S04e08460g Lachancea lanzarotensis ribonuclease H2 catalytic subunit RNH201 XP_022628357.1 748695 D 1245769 CDS LALA0_S04e08482g 34685582 750605..752020 Unknown 1 NW_019212882.1 highly similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; dihydrolipoyllysine-residue acetyltransferase 752020 34685582 LALA0_S04e08482g Lachancea lanzarotensis dihydrolipoyllysine-residue acetyltransferase XP_022628358.1 750605 D 1245769 CDS LALA0_S04e08504g 34685583 753340..753522 Unknown 1 NW_019212882.1 highly similar to uniprot|P53507 Saccharomyces cerevisiae YNL070W TOM7 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex; uncharacterized protein 753522 34685583 LALA0_S04e08504g Lachancea lanzarotensis uncharacterized protein XP_022628359.1 753340 D 1245769 CDS LALA0_S04e08526g 34685584 753809..754732 Unknown 1 NW_019212882.1 similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane; flavin adenine dinucleotide transporter FLX1 754732 34685584 LALA0_S04e08526g Lachancea lanzarotensis flavin adenine dinucleotide transporter FLX1 XP_022628360.1 753809 D 1245769 CDS LALA0_S04e08548g 34685585 complement(join(755098..755666,755966..755999)) Unknown 1 NW_019212882.1 highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C (ohnolog of YNL069C) RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p; 60S ribosomal protein uL13 755999 34685585 LALA0_S04e08548g Lachancea lanzarotensis 60S ribosomal protein uL13 XP_022628361.1 755098 R 1245769 CDS LALA0_S04e08570g 34685586 complement(756493..757164) Unknown 1 NW_019212882.1 similar to uniprot|P40465 Saccharomyces cerevisiae YIL132C CSM2 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis; uncharacterized protein 757164 34685586 LALA0_S04e08570g Lachancea lanzarotensis uncharacterized protein XP_022628362.1 756493 R 1245769 CDS LALA0_S04e08592g 34685587 complement(757547..759808) Unknown 1 NW_019212882.1 similar to uniprot|P40466 Saccharomyces cerevisiae YIL131C (ohnolog of YNL068C) FKH1 Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching; forkhead family transcription factor FKH1 759808 34685587 LALA0_S04e08592g Lachancea lanzarotensis forkhead family transcription factor FKH1 XP_022628363.1 757547 R 1245769 CDS LALA0_S04e08614g 34685588 762467..764863 Unknown 1 NW_019212882.1 similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; uncharacterized protein 764863 34685588 LALA0_S04e08614g Lachancea lanzarotensis uncharacterized protein XP_022628364.1 762467 D 1245769 CDS LALA0_S04e08636g 34685589 complement(764954..772711) Unknown 1 NW_019212882.1 similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p; uncharacterized protein 772711 34685589 LALA0_S04e08636g Lachancea lanzarotensis uncharacterized protein XP_022628365.1 764954 R 1245769 CDS LALA0_S04e08658g 34685590 773721..776783 Unknown 1 NW_019212882.1 similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance; uncharacterized protein 776783 34685590 LALA0_S04e08658g Lachancea lanzarotensis uncharacterized protein XP_022628366.1 773721 D 1245769 CDS LALA0_S04e08680g 34685591 complement(776879..777487) Unknown 1 NW_019212882.1 similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C RRT14 Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis; uncharacterized protein 777487 34685591 LALA0_S04e08680g Lachancea lanzarotensis uncharacterized protein XP_022628367.1 776879 R 1245769 CDS LALA0_S04e08702g 34685592 778303..782259 Unknown 1 NW_019212882.1 similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p; RSC chromatin remodeling complex ATPase subunit STH1 782259 34685592 LALA0_S04e08702g Lachancea lanzarotensis RSC chromatin remodeling complex ATPase subunit STH1 XP_022628368.1 778303 D 1245769 CDS LALA0_S04e08724g 34685593 782527..783102 Unknown 1 NW_019212882.1 highly similar to uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; 60S ribosomal protein uL6 783102 34685593 LALA0_S04e08724g Lachancea lanzarotensis 60S ribosomal protein uL6 XP_022628369.1 782527 D 1245769 CDS LALA0_S04e08746g 34685594 complement(783763..785298) Unknown 1 NW_019212882.1 similar to uniprot|C5DDJ5 Lachancea thermotolerans KLTH0C01496g hypothetical protein; uncharacterized protein 785298 34685594 LALA0_S04e08746g Lachancea lanzarotensis uncharacterized protein XP_022628370.1 783763 R 1245769 CDS LALA0_S04e08768g 34685595 786852..789902 Unknown 1 NW_019212882.1 highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; alpha-ketoglutarate dehydrogenase KGD1 789902 34685595 LALA0_S04e08768g Lachancea lanzarotensis alpha-ketoglutarate dehydrogenase KGD1 XP_022628371.1 786852 D 1245769 CDS LALA0_S04e08790g 34685596 791828..793180 Unknown 1 NW_019212882.1 similar to uniprot|P40472 Saccharomyces cerevisiae YIL123W (ohnolog of YNL066W) SIM1 Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; uncharacterized protein 793180 34685596 LALA0_S04e08790g Lachancea lanzarotensis uncharacterized protein XP_022628372.1 791828 D 1245769 CDS LALA0_S04e08812g 34685597 795056..796852 Unknown 1 NW_019212882.1 similar to uniprot|P40474 Saccharomyces cerevisiae YIL121W QDR2 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake; cation transporter 796852 34685597 LALA0_S04e08812g Lachancea lanzarotensis cation transporter XP_022628373.1 795056 D 1245769 CDS LALA0_S04e08834g 34685598 797278..799059 Unknown 1 NW_019212882.1 similar to uniprot|P40475 Saccharomyces cerevisiae YIL120W (ohnolog of YNL065W) QDR1 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban; uncharacterized protein 799059 34685598 LALA0_S04e08834g Lachancea lanzarotensis uncharacterized protein XP_022628374.1 797278 D 1245769 CDS LALA0_S04e08856g 34685599 complement(799343..800575) Unknown 1 NW_019212882.1 highly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family; type I HSP40 co-chaperone YDJ1 800575 34685599 LALA0_S04e08856g Lachancea lanzarotensis type I HSP40 co-chaperone YDJ1 XP_022628375.1 799343 R 1245769 CDS LALA0_S04e08878g 34685600 802565..803446 Unknown 1 NW_019212882.1 similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1 S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene; S-adenosylmethionine-dependent methyltransferase 803446 34685600 LALA0_S04e08878g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022628376.1 802565 D 1245769 CDS LALA0_S04e08900g 34685601 complement(803473..804915) Unknown 1 NW_019212882.1 similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; tRNA 1-methyladenosine methyltransferase subunit GCD10 804915 34685601 LALA0_S04e08900g Lachancea lanzarotensis tRNA 1-methyladenosine methyltransferase subunit GCD10 XP_022628377.1 803473 R 1245769 CDS LALA0_S04e08922g 34685602 805889..807868 Unknown 1 NW_019212882.1 highly similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA (cytosine-C5-)-methyltransferase NOP2 807868 34685602 LALA0_S04e08922g Lachancea lanzarotensis rRNA (cytosine-C5-)-methyltransferase NOP2 XP_022628378.1 805889 D 1245769 CDS LALA0_S04e08944g 34685603 complement(807997..810231) Unknown 1 NW_019212882.1 highly similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; uncharacterized protein 810231 34685603 LALA0_S04e08944g Lachancea lanzarotensis uncharacterized protein XP_022628379.1 807997 R 1245769 CDS LALA0_S04e08966g 34685604 complement(810582..815774) Unknown 1 NW_019212882.1 similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities; uncharacterized protein 815774 34685604 LALA0_S04e08966g Lachancea lanzarotensis uncharacterized protein XP_022628380.1 810582 R 1245769 CDS LALA0_S04e08988g 34685605 817344..818066 Unknown 1 NW_019212882.1 highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p; Rho family GTPase RHO3 818066 34685605 LALA0_S04e08988g Lachancea lanzarotensis Rho family GTPase RHO3 XP_022628381.1 817344 D 1245769 CDS LALA0_S04e09010g 34685606 complement(818319..819161) Unknown 1 NW_019212882.1 weakly similar to uniprot|P40476 Saccharomyces cerevisiae YIL117C (ohnolog of YNL058C) PRM5 Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; uncharacterized protein 819161 34685606 LALA0_S04e09010g Lachancea lanzarotensis uncharacterized protein XP_022628382.1 818319 R 1245769 CDS LALA0_S04e09032g 34685607 819517..820050 Unknown 1 NW_019212882.1 similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W OCA2 Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene; uncharacterized protein 820050 34685607 LALA0_S04e09032g Lachancea lanzarotensis uncharacterized protein XP_022628383.1 819517 D 1245769 CDS LALA0_S04e09054g 34685608 820461..821633 Unknown 1 NW_019212882.1 similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; histidinol-phosphate transaminase 821633 34685608 LALA0_S04e09054g Lachancea lanzarotensis histidinol-phosphate transaminase XP_022628384.1 820461 D 1245769 CDS LALA0_S04e09076g 34685609 complement(821675..825835) Unknown 1 NW_019212882.1 weakly similar to uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore; part of the nuclear pore that is found exclusively on the cytoplasmic side; required for mRNA export; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; FG-nucleoporin NUP159 825835 34685609 LALA0_S04e09076g Lachancea lanzarotensis FG-nucleoporin NUP159 XP_022628385.1 821675 R 1245769 CDS LALA0_S04e09098g 34685610 complement(826316..827161) Unknown 1 NW_019212882.1 highly similar to uniprot|P40478 Saccharomyces cerevisiae YIL114C (ohnolog of YNL055C) POR2 Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability; porin POR1 827161 34685610 LALA0_S04e09098g Lachancea lanzarotensis porin POR1 XP_022628386.1 826316 R 1245769 CDS LALA0_S04e09142g 34685612 829382..832150 Unknown 1 NW_019212882.1 weakly similar to uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; uncharacterized protein 832150 34685612 LALA0_S04e09142g Lachancea lanzarotensis uncharacterized protein XP_022628387.1 829382 D 1245769 CDS LALA0_S04e09164g 34685613 complement(832260..832952) Unknown 1 NW_019212882.1 similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 832952 34685613 LALA0_S04e09164g Lachancea lanzarotensis uncharacterized protein XP_022628388.1 832260 R 1245769 CDS LALA0_S04e09186g 34685614 complement(833335..833745) Unknown 1 NW_019212882.1 some similarities with uniprot|P50088 Saccharomyces cerevisiae YGR236C SPG1 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 833745 34685614 LALA0_S04e09186g Lachancea lanzarotensis uncharacterized protein XP_022628389.1 833335 R 1245769 CDS LALA0_S04e09208g 34685615 complement(834204..836210) Unknown 1 NW_019212882.1 similar to uniprot|P50089 Saccharomyces cerevisiae YGR237C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 836210 34685615 LALA0_S04e09208g Lachancea lanzarotensis uncharacterized protein XP_022628390.1 834204 R 1245769 CDS LALA0_S04e09230g 34685616 837182..837631 Unknown 1 NW_019212882.1 weakly similar to uniprot|C5DDJ3 Lachancea thermotolerans KLTH0C01452g TDA11 topoisomerase I damage affected protein 11; uncharacterized protein 837631 34685616 LALA0_S04e09230g Lachancea lanzarotensis uncharacterized protein XP_022628391.1 837182 D 1245769 CDS LALA0_S04e09252g 34685617 complement(837710..840712) Unknown 1 NW_019212882.1 similar to uniprot|P38853 Saccharomyces cerevisiae YHR158C (ohnolog of YGR238C) KEL1 Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; uncharacterized protein 840712 34685617 LALA0_S04e09252g Lachancea lanzarotensis uncharacterized protein XP_022628392.1 837710 R 1245769 CDS LALA0_S04e09274g 34685618 842071..843117 Unknown 1 NW_019212882.1 similar to uniprot|C5DDH4 Lachancea thermotolerans KLTH0C01012g hypothetical protein; uncharacterized protein 843117 34685618 LALA0_S04e09274g Lachancea lanzarotensis uncharacterized protein XP_022628393.1 842071 D 1245769 CDS LALA0_S04e09296g 34685619 complement(843240..844079) Unknown 1 NW_019212882.1 weakly similar to uniprot|P38855 Saccharomyces cerevisiae YHR160C (ohnolog of YGR239C) PEX18 Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; uncharacterized protein 844079 34685619 LALA0_S04e09296g Lachancea lanzarotensis uncharacterized protein XP_022628394.1 843240 R 1245769 CDS LALA0_S04e09318g 34685620 845696..847441 Unknown 1 NW_019212882.1 weakly similar to uniprot|Q06150 Saccharomyces cerevisiae YLR267W BOP2 Protein of unknown function; uncharacterized protein 847441 34685620 LALA0_S04e09318g Lachancea lanzarotensis uncharacterized protein XP_022628395.1 845696 D 1245769 CDS LALA0_S04e09340g 34685621 complement(847908..849086) Unknown 1 NW_019212882.1 highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; H(+)-transporting V1 sector ATPase subunit C 849086 34685621 LALA0_S04e09340g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit C XP_022628396.1 847908 R 1245769 CDS LALA0_S04e09362g 34685622 complement(join(849689..850725,851081..851288)) Unknown 1 NW_019212882.1 similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; translation elongation factor EF1B gamma 851288 34685622 LALA0_S04e09362g Lachancea lanzarotensis translation elongation factor EF1B gamma XP_022628397.1 849689 R 1245769 CDS LALA0_S04e09384g 34685623 852174..853553 Unknown 1 NW_019212882.1 similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF- 6 family; ribosome biosynthesis protein RRP14 853553 34685623 LALA0_S04e09384g Lachancea lanzarotensis ribosome biosynthesis protein RRP14 XP_022628398.1 852174 D 1245769 CDS LALA0_S04e09406g 34685624 853968..856604 Unknown 1 NW_019212882.1 similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Mitochondrial protein of unknown function; uncharacterized protein 856604 34685624 LALA0_S04e09406g Lachancea lanzarotensis uncharacterized protein XP_022628399.1 853968 D 1245769 CDS LALA0_S04e09428g 34685625 complement(856668..857885) Unknown 1 NW_019212882.1 similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; uncharacterized protein 857885 34685625 LALA0_S04e09428g Lachancea lanzarotensis uncharacterized protein XP_022628400.1 856668 R 1245769 CDS LALA0_S04e09450g 34685626 859026..860339 Unknown 1 NW_019212882.1 weakly similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W CLD1 Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; carboxylic ester hydrolase 860339 34685626 LALA0_S04e09450g Lachancea lanzarotensis carboxylic ester hydrolase XP_022628401.1 859026 D 1245769 CDS LALA0_S04e09472g 34685627 860722..861909 Unknown 1 NW_019212882.1 similar to uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; uncharacterized protein 861909 34685627 LALA0_S04e09472g Lachancea lanzarotensis uncharacterized protein XP_022628402.1 860722 D 1245769 CDS LALA0_S04e09494g 34685628 complement(861925..862260) Unknown 1 NW_019212882.1 similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc; uncharacterized protein 862260 34685628 LALA0_S04e09494g Lachancea lanzarotensis uncharacterized protein XP_022628403.1 861925 R 1245769 CDS LALA0_S04e09516g 34685629 complement(862418..863416) Unknown 1 NW_019212882.1 highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; malate dehydrogenase MDH1 863416 34685629 LALA0_S04e09516g Lachancea lanzarotensis malate dehydrogenase MDH1 XP_022628404.1 862418 R 1245769 CDS LALA0_S04e09538g 34685630 complement(864739..865788) Unknown 1 NW_019212882.1 similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C ZTA1 NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin; NADPH:quinone reductase 865788 34685630 LALA0_S04e09538g Lachancea lanzarotensis NADPH:quinone reductase XP_022628405.1 864739 R 1245769 CDS LALA0_S04e09560g 34685631 866701..867669 Unknown 1 NW_019212882.1 weakly similar to uniprot|P54005 Saccharomyces cerevisiae YMR316W DIA1 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 867669 34685631 LALA0_S04e09560g Lachancea lanzarotensis uncharacterized protein XP_022628406.1 866701 D 1245769 CDS LALA0_S04e09582g 34685632 869223..870149 Unknown 1 NW_019212882.1 weakly similar to uniprot|P54005 Saccharomyces cerevisiae YMR316W DIA1 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 870149 34685632 LALA0_S04e09582g Lachancea lanzarotensis uncharacterized protein XP_022628407.1 869223 D 1245769 CDS LALA0_S04e09604g 34685633 complement(870879..871262) Unknown 1 NW_019212882.1 similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; sulfiredoxin 871262 34685633 LALA0_S04e09604g Lachancea lanzarotensis sulfiredoxin XP_022628408.1 870879 R 1245769 CDS LALA0_S04e09626g 34685634 complement(871473..872834) Unknown 1 NW_019212882.1 similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; guanine nucleotide-binding protein subunit alpha 872834 34685634 LALA0_S04e09626g Lachancea lanzarotensis guanine nucleotide-binding protein subunit alpha XP_022628409.1 871473 R 1245769 CDS LALA0_S04e09648g 34685635 874338..875126 Unknown 1 NW_019212882.1 similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; cytochrome c1 heme lyase CYT2 875126 34685635 LALA0_S04e09648g Lachancea lanzarotensis cytochrome c1 heme lyase CYT2 XP_022628410.1 874338 D 1245769 CDS LALA0_S04e09670g 34685636 complement(875459..875740) Unknown 1 NW_019212882.1 highly similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A TIM10 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; protein transporter TIM10 875740 34685636 LALA0_S04e09670g Lachancea lanzarotensis protein transporter TIM10 XP_022628411.1 875459 R 1245769 CDS LALA0_S04e09692g 34685637 complement(876517..878064) Unknown 1 NW_019212882.1 weakly similar to uniprot|P36076 Saccharomyces cerevisiae YKL088W CAB3 Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC; phosphopantothenoylcysteine decarboxylase complex subunit CAB3 878064 34685637 LALA0_S04e09692g Lachancea lanzarotensis phosphopantothenoylcysteine decarboxylase complex subunit CAB3 XP_022628412.1 876517 R 1245769 CDS LALA0_S04e09714g 34685638 complement(878558..879388) Unknown 1 NW_019212882.1 weakly similar to Lachancea thermotolerans KLTH0C00550g hypothetical protein; uncharacterized protein 879388 34685638 LALA0_S04e09714g Lachancea lanzarotensis uncharacterized protein XP_022628413.1 878558 R 1245769 CDS LALA0_S04e09736g 34685639 880427..881479 Unknown 1 NW_019212882.1 similar to uniprot|P07266 Saccharomyces cerevisiae YIR021W (ohnolog of YKL011C) MRS1 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; cruciform cutting endonuclease 881479 34685639 LALA0_S04e09736g Lachancea lanzarotensis cruciform cutting endonuclease XP_022628414.1 880427 D 1245769 CDS LALA0_S04e09758g 34685640 complement(881571..882239) Unknown 1 NW_019212882.1 similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability; uncharacterized protein 882239 34685640 LALA0_S04e09758g Lachancea lanzarotensis uncharacterized protein XP_022628415.1 881571 R 1245769 CDS LALA0_S04e09780g 34685641 883135..883641 Unknown 1 NW_019212882.1 highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; signal peptidase complex catalytic subunit SEC11 883641 34685641 LALA0_S04e09780g Lachancea lanzarotensis signal peptidase complex catalytic subunit SEC11 XP_022628416.1 883135 D 1245769 CDS LALA0_S04e09802g 34685642 complement(883715..885460) Unknown 1 NW_019212882.1 similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex; uncharacterized protein 885460 34685642 LALA0_S04e09802g Lachancea lanzarotensis uncharacterized protein XP_022628417.1 883715 R 1245769 CDS LALA0_S04e09824g 34685643 886036..886551 Unknown 1 NW_019212882.1 highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; uncharacterized protein 886551 34685643 LALA0_S04e09824g Lachancea lanzarotensis uncharacterized protein XP_022628418.1 886036 D 1245769 CDS LALA0_S04e09846g 34685644 887138..890338 Unknown 1 NW_019212882.1 similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; uncharacterized protein 890338 34685644 LALA0_S04e09846g Lachancea lanzarotensis uncharacterized protein XP_022628419.1 887138 D 1245769 CDS LALA0_S04e09868g 34685645 complement(890416..891183) Unknown 1 NW_019212882.1 weakly similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect; uncharacterized protein 891183 34685645 LALA0_S04e09868g Lachancea lanzarotensis uncharacterized protein XP_022628420.1 890416 R 1245769 CDS LALA0_S04e09890g 34685646 891579..896723 Unknown 1 NW_019212882.1 similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit; uncharacterized protein 896723 34685646 LALA0_S04e09890g Lachancea lanzarotensis uncharacterized protein XP_022628421.1 891579 D 1245769 CDS LALA0_S04e09912g 34685647 complement(896966..899413) Unknown 1 NW_019212882.1 similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain; uncharacterized protein 899413 34685647 LALA0_S04e09912g Lachancea lanzarotensis uncharacterized protein XP_022628422.1 896966 R 1245769 CDS LALA0_S04e09956g 34685649 900935..901459 Unknown 1 NW_019212882.1 highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit d 901459 34685649 LALA0_S04e09956g Lachancea lanzarotensis F1F0 ATP synthase subunit d XP_022628423.1 900935 D 1245769 CDS LALA0_S04e09978g 34685650 901623..903602 Unknown 1 NW_019212882.1 similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities; ATP-dependent 5'-3' DNA helicase HCS1 903602 34685650 LALA0_S04e09978g Lachancea lanzarotensis ATP-dependent 5'-3' DNA helicase HCS1 XP_022628424.1 901623 D 1245769 CDS LALA0_S04e10000g 34685651 complement(903633..904619) Unknown 1 NW_019212882.1 highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; WD-repeat containing protein SWD2 904619 34685651 LALA0_S04e10000g Lachancea lanzarotensis WD-repeat containing protein SWD2 XP_022628425.1 903633 R 1245769 CDS LALA0_S04e10022g 34685652 join(905336..905344,905456..905767) Unknown 1 NW_019212882.1 weakly similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 905767 34685652 LALA0_S04e10022g Lachancea lanzarotensis uncharacterized protein XP_022628426.1 905336 D 1245769 CDS LALA0_S04e10044g 34685653 906047..907027 Unknown 1 NW_019212882.1 weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase; uncharacterized protein 907027 34685653 LALA0_S04e10044g Lachancea lanzarotensis uncharacterized protein XP_022628427.1 906047 D 1245769 CDS LALA0_S04e10066g 34685654 complement(907062..908120) Unknown 1 NW_019212882.1 similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases; tyrosine protein phosphatase YVH1 908120 34685654 LALA0_S04e10066g Lachancea lanzarotensis tyrosine protein phosphatase YVH1 XP_022628428.1 907062 R 1245769 CDS LALA0_S04e10088g 34685655 complement(908331..909290) Unknown 1 NW_019212882.1 similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor; bifunctional protein farnesyltransferase/protein geranylgeranyltransferase 909290 34685655 LALA0_S04e10088g Lachancea lanzarotensis bifunctional protein farnesyltransferase/protein geranylgeranyltransferase XP_022628429.1 908331 R 1245769 CDS LALA0_S04e10110g 34685656 911660..914965 Unknown 1 NW_019212882.1 similar to uniprot|P40578 Saccharomyces cerevisiae YIR033W (ohnolog of YKL020C) MGA2 ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; uncharacterized protein 914965 34685656 LALA0_S04e10110g Lachancea lanzarotensis uncharacterized protein XP_022628430.1 911660 D 1245769 CDS LALA0_S04e10132g 34685657 915266..916474 Unknown 1 NW_019212882.1 similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats; uncharacterized protein 916474 34685657 LALA0_S04e10132g Lachancea lanzarotensis uncharacterized protein XP_022628431.1 915266 D 1245769 CDS LALA0_S04e10154g 34685658 complement(916625..917746) Unknown 1 NW_019212882.1 highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity; saccharopine dehydrogenase (NAD+, L-lysine-forming) 917746 34685658 LALA0_S04e10154g Lachancea lanzarotensis saccharopine dehydrogenase (NAD+, L-lysine-forming) XP_022628432.1 916625 R 1245769 CDS LALA0_S04e10176g 34685659 919135..921393 Unknown 1 NW_019212882.1 similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; anaphase promoting complex subunit CDC16 921393 34685659 LALA0_S04e10176g Lachancea lanzarotensis anaphase promoting complex subunit CDC16 XP_022628433.1 919135 D 1245769 CDS LALA0_S04e10198g 34685660 complement(921471..922334) Unknown 1 NW_019212882.1 weakly similar to uniprot|C5DML8 Lachancea thermotolerans KLTH0G09966g hypothetical protein; uncharacterized protein 922334 34685660 LALA0_S04e10198g Lachancea lanzarotensis uncharacterized protein XP_022628434.1 921471 R 1245769 CDS LALA0_S04e10220g 34685661 complement(922609..923490) Unknown 1 NW_019212882.1 some similarities with uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6 Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); uncharacterized protein 923490 34685661 LALA0_S04e10220g Lachancea lanzarotensis uncharacterized protein XP_022628435.1 922609 R 1245769 CDS LALA0_S04e10242g 34685662 complement(join(924361..924690,924753..925178)) Unknown 1 NW_019212882.1 similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C Putative cytoplasmic protein of unknown function; sepiapterin reductase family protein 925178 34685662 LALA0_S04e10242g Lachancea lanzarotensis sepiapterin reductase family protein XP_022628436.1 924361 R 1245769 CDS LALA0_S04e10264g 34685663 926108..928021 Unknown 1 NW_019212882.1 similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; uncharacterized protein 928021 34685663 LALA0_S04e10264g Lachancea lanzarotensis uncharacterized protein XP_022628437.1 926108 D 1245769 CDS LALA0_S04e10286g 34685664 929395..931083 Unknown 1 NW_019212882.1 highly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; uncharacterized protein 931083 34685664 LALA0_S04e10286g Lachancea lanzarotensis uncharacterized protein XP_022628438.1 929395 D 1245769 CDS LALA0_S04e10308g 34685665 join(933829..936147,936153..937132) Unknown 1 NW_019212882.1 weakly similar to uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p; 937132 34685665 LALA0_S04e10308g Lachancea lanzarotensis 933829 D 1245769 CDS LALA0_S05e00100g 34685666 273..1373 Unknown 1 NW_019212883.1 highly similar to Lachancea thermotolerans KLTH0F15818g hypothetical protein; uncharacterized protein 1373 34685666 LALA0_S05e00100g Lachancea lanzarotensis uncharacterized protein XP_022628439.1 273 D 1245769 CDS LALA0_S05e00144g 34685668 2121..2975 Unknown 1 NW_019212883.1 similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; uncharacterized protein 2975 34685668 LALA0_S05e00144g Lachancea lanzarotensis uncharacterized protein XP_022628440.1 2121 D 1245769 CDS LALA0_S05e00166g 34685669 complement(3095..4612) Unknown 1 NW_019212883.1 similar to uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis; phosphoprotein phosphatase CDC14 4612 34685669 LALA0_S05e00166g Lachancea lanzarotensis phosphoprotein phosphatase CDC14 XP_022628441.1 3095 R 1245769 CDS LALA0_S05e00408g 34685672 25788..26858 Unknown 1 NW_019212883.1 similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16); uncharacterized protein 26858 34685672 LALA0_S05e00408g Lachancea lanzarotensis uncharacterized protein XP_022628443.1 25788 D 1245769 CDS LALA0_S05e00430g 34685673 complement(26908..28689) Unknown 1 NW_019212883.1 weakly similar to uniprot|P43595 Saccharomyces cerevisiae YFR012W (ohnolog of YOL019W) Putative protein of unknown function; uncharacterized protein 28689 34685673 LALA0_S05e00430g Lachancea lanzarotensis uncharacterized protein XP_022628444.1 26908 R 1245769 CDS LALA0_S05e00452g 34685674 30080..30541 Unknown 1 NW_019212883.1 similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C AIM13 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss; uncharacterized protein 30541 34685674 LALA0_S05e00452g Lachancea lanzarotensis uncharacterized protein XP_022628445.1 30080 D 1245769 CDS LALA0_S05e00474g 34685675 complement(join(30707..32172,32240..32252)) Unknown 1 NW_019212883.1 highly similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; ubiquitin-specific protease UBP6 32252 34685675 LALA0_S05e00474g Lachancea lanzarotensis ubiquitin-specific protease UBP6 XP_022628446.1 30707 R 1245769 CDS LALA0_S05e00496g 34685676 33943..36903 Unknown 1 NW_019212883.1 highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; exosome catalytic subunit DIS3 36903 34685676 LALA0_S05e00496g Lachancea lanzarotensis exosome catalytic subunit DIS3 XP_022628447.1 33943 D 1245769 CDS LALA0_S05e00518g 34685677 complement(37016..39274) Unknown 1 NW_019212883.1 highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; uncharacterized protein 39274 34685677 LALA0_S05e00518g Lachancea lanzarotensis uncharacterized protein XP_022628448.1 37016 R 1245769 CDS LALA0_S05e00562g 34685679 39987..41201 Unknown 1 NW_019212883.1 similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C TSR4 Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2; uncharacterized protein 41201 34685679 LALA0_S05e00562g Lachancea lanzarotensis uncharacterized protein XP_022628449.1 39987 D 1245769 CDS LALA0_S05e00584g 34685680 complement(41246..43267) Unknown 1 NW_019212883.1 similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2; translation initiation factor 2 43267 34685680 LALA0_S05e00584g Lachancea lanzarotensis translation initiation factor 2 XP_022628450.1 41246 R 1245769 CDS LALA0_S05e00606g 34685681 complement(43558..44793) Unknown 1 NW_019212883.1 weakly similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C AIM17 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; uncharacterized protein 44793 34685681 LALA0_S05e00606g Lachancea lanzarotensis uncharacterized protein XP_022628451.1 43558 R 1245769 CDS LALA0_S05e00628g 34685682 complement(45102..45659) Unknown 1 NW_019212883.1 weakly similar to uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein; uncharacterized protein 45659 34685682 LALA0_S05e00628g Lachancea lanzarotensis uncharacterized protein XP_022628452.1 45102 R 1245769 CDS LALA0_S05e00650g 34685683 complement(46222..48150) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1; uncharacterized protein 48150 34685683 LALA0_S05e00650g Lachancea lanzarotensis uncharacterized protein XP_022628453.1 46222 R 1245769 CDS LALA0_S05e00672g 34685684 49747..50997 Unknown 1 NW_019212883.1 highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis; phosphoglycerate kinase 50997 34685684 LALA0_S05e00672g Lachancea lanzarotensis phosphoglycerate kinase XP_022628454.1 49747 D 1245769 CDS LALA0_S05e00694g 34685685 complement(51116..52807) Unknown 1 NW_019212883.1 similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta; DNA-directed DNA polymerase IV 52807 34685685 LALA0_S05e00694g Lachancea lanzarotensis DNA-directed DNA polymerase IV XP_022628455.1 51116 R 1245769 CDS LALA0_S05e00716g 34685686 complement(53137..54042) Unknown 1 NW_019212883.1 similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Putative protein of unknown function; YCR015C is not an essential gene; uncharacterized protein 54042 34685686 LALA0_S05e00716g Lachancea lanzarotensis uncharacterized protein XP_022628456.1 53137 R 1245769 CDS LALA0_S05e00738g 34685687 54685..55518 Unknown 1 NW_019212883.1 similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis; RNA-binding ribosome assembly factor RBP95 55518 34685687 LALA0_S05e00738g Lachancea lanzarotensis RNA-binding ribosome assembly factor RBP95 XP_022628457.1 54685 D 1245769 CDS LALA0_S05e00760g 34685688 55962..56696 Unknown 1 NW_019212883.1 similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; isoamyl acetate-hydrolyzing esterase 56696 34685688 LALA0_S05e00760g Lachancea lanzarotensis isoamyl acetate-hydrolyzing esterase XP_022628458.1 55962 D 1245769 CDS LALA0_S05e00782g 34685689 complement(57267..58145) Unknown 1 NW_019212883.1 similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; inositol pentakisphosphate 2-kinase 58145 34685689 LALA0_S05e00782g Lachancea lanzarotensis inositol pentakisphosphate 2-kinase XP_022628459.1 57267 R 1245769 CDS LALA0_S05e00804g 34685690 58358..59500 Unknown 1 NW_019212883.1 highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; deoxyhypusine synthase 59500 34685690 LALA0_S05e00804g Lachancea lanzarotensis deoxyhypusine synthase XP_022628460.1 58358 D 1245769 CDS LALA0_S05e00826g 34685691 61325..62989 Unknown 1 NW_019212883.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 62989 34685691 LALA0_S05e00826g Lachancea lanzarotensis uncharacterized protein XP_022628461.1 61325 D 1245769 CDS LALA0_S05e00848g 34685692 63530..63898 Unknown 1 NW_019212883.1 weakly similar to uniprot|P40342 Saccharomyces cerevisiae YNR004W SWM2 Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds; uncharacterized protein 63898 34685692 LALA0_S05e00848g Lachancea lanzarotensis uncharacterized protein XP_022628462.1 63530 D 1245769 CDS LALA0_S05e00870g 34685693 complement(63959..67009) Unknown 1 NW_019212883.1 similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; uncharacterized protein 67009 34685693 LALA0_S05e00870g Lachancea lanzarotensis uncharacterized protein XP_022628463.1 63959 R 1245769 CDS LALA0_S05e00892g 34685694 complement(67315..69429) Unknown 1 NW_019212883.1 highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; 1,4-alpha-glucan branching enzyme 69429 34685694 LALA0_S05e00892g Lachancea lanzarotensis 1,4-alpha-glucan branching enzyme XP_022628464.1 67315 R 1245769 CDS LALA0_S05e00914g 34685695 complement(join(69993..70749,70838..70842)) Unknown 1 NW_019212883.1 similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; E2 ubiquitin-conjugating protein UBC8 70842 34685695 LALA0_S05e00914g Lachancea lanzarotensis E2 ubiquitin-conjugating protein UBC8 XP_022628465.1 69993 R 1245769 CDS LALA0_S05e00936g 34685696 complement(71118..71339) Unknown 1 NW_019212883.1 similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance; uncharacterized protein 71339 34685696 LALA0_S05e00936g Lachancea lanzarotensis uncharacterized protein XP_022628466.1 71118 R 1245769 CDS LALA0_S05e00958g 34685697 71939..72205 Unknown 1 NW_019212883.1 similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family; uncharacterized protein 72205 34685697 LALA0_S05e00958g Lachancea lanzarotensis uncharacterized protein XP_022628467.1 71939 D 1245769 CDS LALA0_S05e00980g 34685698 72633..73274 Unknown 1 NW_019212883.1 similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin; uncharacterized protein 73274 34685698 LALA0_S05e00980g Lachancea lanzarotensis uncharacterized protein XP_022628468.1 72633 D 1245769 CDS LALA0_S05e01002g 34685699 complement(73280..74332) Unknown 1 NW_019212883.1 similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles; uncharacterized protein 74332 34685699 LALA0_S05e01002g Lachancea lanzarotensis uncharacterized protein XP_022628469.1 73280 R 1245769 CDS LALA0_S05e01046g 34685701 complement(75411..77102) Unknown 1 NW_019212883.1 highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions; protein anchor VAC8 77102 34685701 LALA0_S05e01046g Lachancea lanzarotensis protein anchor VAC8 XP_022628470.1 75411 R 1245769 CDS LALA0_S05e01068g 34685702 complement(78108..79568) Unknown 1 NW_019212883.1 similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; uncharacterized protein 79568 34685702 LALA0_S05e01068g Lachancea lanzarotensis uncharacterized protein XP_022628471.1 78108 R 1245769 CDS LALA0_S05e01090g 34685703 80003..80596 Unknown 1 NW_019212883.1 similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins; uncharacterized protein 80596 34685703 LALA0_S05e01090g Lachancea lanzarotensis uncharacterized protein XP_022628472.1 80003 D 1245769 CDS LALA0_S05e01112g 34685704 complement(80928..81869) Unknown 1 NW_019212883.1 weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; uncharacterized protein 81869 34685704 LALA0_S05e01112g Lachancea lanzarotensis uncharacterized protein XP_022628473.1 80928 R 1245769 CDS LALA0_S05e01134g 34685705 complement(83583..84893) Unknown 1 NW_019212883.1 similar to uniprot|C5E3J9 Lachancea thermotolerans KLTH0H14190g hypothetical protein; uncharacterized protein 84893 34685705 LALA0_S05e01134g Lachancea lanzarotensis uncharacterized protein XP_022628474.1 83583 R 1245769 CDS LALA0_S05e01156g 34685706 86479..87492 Unknown 1 NW_019212883.1 weakly similar to uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery; uncharacterized protein 87492 34685706 LALA0_S05e01156g Lachancea lanzarotensis uncharacterized protein XP_022628475.1 86479 D 1245769 CDS LALA0_S05e01178g 34685707 88381..88500 Unknown 1 NW_019212883.1 similar to uniprot|P40975 Saccharomyces cerevisiae YEL017C-A (ohnolog of YCR024C-A) PMP2 Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1; proteolipid ATPase 88500 34685707 LALA0_S05e01178g Lachancea lanzarotensis proteolipid ATPase XP_022628476.1 88381 D 1245769 CDS LALA0_S05e01200g 34685708 complement(90148..90804) Unknown 1 NW_019212883.1 weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex; uncharacterized protein 90804 34685708 LALA0_S05e01200g Lachancea lanzarotensis uncharacterized protein XP_022628477.1 90148 R 1245769 CDS LALA0_S05e01222g 34685709 90925..91716 Unknown 1 NW_019212883.1 similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; SUMO ligase MMS21 91716 34685709 LALA0_S05e01222g Lachancea lanzarotensis SUMO ligase MMS21 XP_022628478.1 90925 D 1245769 CDS LALA0_S05e01244g 34685710 91830..93281 Unknown 1 NW_019212883.1 similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase; asparagine--tRNA ligase SLM5 93281 34685710 LALA0_S05e01244g Lachancea lanzarotensis asparagine--tRNA ligase SLM5 XP_022628479.1 91830 D 1245769 CDS LALA0_S05e01266g 34685711 93557..95215 Unknown 1 NW_019212883.1 similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical protein with low sequence identity to Pdc1p; uncharacterized protein 95215 34685711 LALA0_S05e01266g Lachancea lanzarotensis uncharacterized protein XP_022628480.1 93557 D 1245769 CDS LALA0_S05e01288g 34685712 complement(95947..96210) Unknown 1 NW_019212883.1 highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; protein transporter TIM9 96210 34685712 LALA0_S05e01288g Lachancea lanzarotensis protein transporter TIM9 XP_022628481.1 95947 R 1245769 CDS LALA0_S05e01310g 34685713 complement(96542..97360) Unknown 1 NW_019212883.1 highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound; orotidine-5'-phosphate decarboxylase 97360 34685713 LALA0_S05e01310g Lachancea lanzarotensis orotidine-5'-phosphate decarboxylase XP_022628482.1 96542 R 1245769 CDS LALA0_S05e01332g 34685714 98005..99270 Unknown 1 NW_019212883.1 similar to uniprot|C5E3J9 Lachancea thermotolerans KLTH0H14190g hypothetical protein; uncharacterized protein 99270 34685714 LALA0_S05e01332g Lachancea lanzarotensis uncharacterized protein XP_022628483.1 98005 D 1245769 CDS LALA0_S05e01354g 34685715 complement(99344..103540) Unknown 1 NW_019212883.1 similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W (ohnolog of YJR031C) GEA2 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p; Arf family guanine nucleotide exchange factor GEA2 103540 34685715 LALA0_S05e01354g Lachancea lanzarotensis Arf family guanine nucleotide exchange factor GEA2 XP_022628484.1 99344 R 1245769 CDS LALA0_S05e01376g 34685716 104391..105575 Unknown 1 NW_019212883.1 similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; peptidylprolyl isomerase CPR7 105575 34685716 LALA0_S05e01376g Lachancea lanzarotensis peptidylprolyl isomerase CPR7 XP_022628485.1 104391 D 1245769 CDS LALA0_S05e01398g 34685717 complement(105612..109619) Unknown 1 NW_019212883.1 similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate; uncharacterized protein 109619 34685717 LALA0_S05e01398g Lachancea lanzarotensis uncharacterized protein XP_022628486.1 105612 R 1245769 CDS LALA0_S05e01420g 34685718 110630..110956 Unknown 1 NW_019212883.1 highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif; uncharacterized protein 110956 34685718 LALA0_S05e01420g Lachancea lanzarotensis uncharacterized protein XP_022628487.1 110630 D 1245769 CDS LALA0_S05e01442g 34685719 111389..114478 Unknown 1 NW_019212883.1 similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein; DNA-dependent ATPase RAD26 114478 34685719 LALA0_S05e01442g Lachancea lanzarotensis DNA-dependent ATPase RAD26 XP_022628488.1 111389 D 1245769 CDS LALA0_S05e01464g 34685720 114681..116696 Unknown 1 NW_019212883.1 similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene; uncharacterized protein 116696 34685720 LALA0_S05e01464g Lachancea lanzarotensis uncharacterized protein XP_022628489.1 114681 D 1245769 CDS LALA0_S05e01486g 34685721 complement(117241..117885) Unknown 1 NW_019212883.1 highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; ubiquinol--cytochrome-c reductase catalytic subunit RIP1 117885 34685721 LALA0_S05e01486g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase catalytic subunit RIP1 XP_022628490.1 117241 R 1245769 CDS LALA0_S05e01508g 34685722 complement(118948..121473) Unknown 1 NW_019212883.1 similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; uncharacterized protein 121473 34685722 LALA0_S05e01508g Lachancea lanzarotensis uncharacterized protein XP_022628491.1 118948 R 1245769 CDS LALA0_S05e01530g 34685723 121959..125327 Unknown 1 NW_019212883.1 weakly similar to uniprot|P39991 Saccharomyces cerevisiae YEL025C (ohnolog of YJR039W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 125327 34685723 LALA0_S05e01530g Lachancea lanzarotensis uncharacterized protein XP_022628492.1 121959 D 1245769 CDS LALA0_S05e01552g 34685724 complement(125553..125936) Unknown 1 NW_019212883.1 highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; RNA binding protein SNU13 125936 34685724 LALA0_S05e01552g Lachancea lanzarotensis RNA binding protein SNU13 XP_022628493.1 125553 R 1245769 CDS LALA0_S05e01574g 34685725 126797..129088 Unknown 1 NW_019212883.1 similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; uncharacterized protein 129088 34685725 LALA0_S05e01574g Lachancea lanzarotensis uncharacterized protein XP_022628494.1 126797 D 1245769 CDS LALA0_S05e01596g 34685726 complement(129149..132628) Unknown 1 NW_019212883.1 weakly similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis; uncharacterized protein 132628 34685726 LALA0_S05e01596g Lachancea lanzarotensis uncharacterized protein XP_022628495.1 129149 R 1245769 CDS LALA0_S05e01618g 34685727 132912..135170 Unknown 1 NW_019212883.1 similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; the Nup84 subcomplex has a role in transcription elongation; uncharacterized protein 135170 34685727 LALA0_S05e01618g Lachancea lanzarotensis uncharacterized protein XP_022628496.1 132912 D 1245769 CDS LALA0_S05e01640g 34685728 complement(135565..136047) Unknown 1 NW_019212883.1 highly similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W VMA3 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis; H(+)-transporting V0 sector ATPase subunit c 136047 34685728 LALA0_S05e01640g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit c XP_022628497.1 135565 R 1245769 CDS LALA0_S05e01662g 34685729 complement(136385..136762) Unknown 1 NW_019212883.1 hypothetical protein; 136762 34685729 LALA0_S05e01662g Lachancea lanzarotensis 136385 R 1245769 CDS LALA0_S05e01684g 34685730 complement(137987..139036) Unknown 1 NW_019212883.1 similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p; DNA polymerase delta subunit POL32 139036 34685730 LALA0_S05e01684g Lachancea lanzarotensis DNA polymerase delta subunit POL32 XP_022628498.1 137987 R 1245769 CDS LALA0_S05e01728g 34685732 complement(139491..140369) Unknown 1 NW_019212883.1 weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; uncharacterized protein 140369 34685732 LALA0_S05e01728g Lachancea lanzarotensis uncharacterized protein XP_022628499.1 139491 R 1245769 CDS LALA0_S05e01750g 34685733 141176..142102 Unknown 1 NW_019212883.1 similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C BUD16 Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK); uncharacterized protein 142102 34685733 LALA0_S05e01750g Lachancea lanzarotensis uncharacterized protein XP_022628500.1 141176 D 1245769 CDS LALA0_S05e01772g 34685734 142789..143643 Unknown 1 NW_019212883.1 weakly similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology; hydroxyacyl-thioester dehydratase HTD2 143643 34685734 LALA0_S05e01772g Lachancea lanzarotensis hydroxyacyl-thioester dehydratase HTD2 XP_022628501.1 142789 D 1245769 CDS LALA0_S05e01794g 34685735 144180..145523 Unknown 1 NW_019212883.1 similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations; uncharacterized protein 145523 34685735 LALA0_S05e01794g Lachancea lanzarotensis uncharacterized protein XP_022628502.1 144180 D 1245769 CDS LALA0_S05e01816g 34685736 complement(145595..146662) Unknown 1 NW_019212883.1 highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2); exosome non-catalytic core subunit RRP4 146662 34685736 LALA0_S05e01816g Lachancea lanzarotensis exosome non-catalytic core subunit RRP4 XP_022628503.1 145595 R 1245769 CDS LALA0_S05e01838g 34685737 147441..148946 Unknown 1 NW_019212883.1 similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya; tRNA (guanine) methyltransferase 148946 34685737 LALA0_S05e01838g Lachancea lanzarotensis tRNA (guanine) methyltransferase XP_022628504.1 147441 D 1245769 CDS LALA0_S05e01860g 34685738 150216..150902 Unknown 1 NW_019212883.1 similar to uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity; uncharacterized protein 150902 34685738 LALA0_S05e01860g Lachancea lanzarotensis uncharacterized protein XP_022628505.1 150216 D 1245769 CDS LALA0_S05e01926g 34685740 join(151470..152072,152072..152605,152608..153090,153090..153212,153214..153285,153287..153391,153391..153522,153524..153772,153774..155624) Unknown 1 NW_019212883.1 similar to uniprot|Q99315 Saccharomyces cerevisiae YGR109W-B TY3B-G Transposon Ty3-G Gag-Pol polyprotein; 155624 34685740 LALA0_S05e01926g Lachancea lanzarotensis 151470 D 1245769 CDS LALA0_S05e01970g 34685741 156480..158009 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W HIM1 Protein of unknown function involved in DNA repair; uncharacterized protein 158009 34685741 LALA0_S05e01970g Lachancea lanzarotensis uncharacterized protein XP_022628506.1 156480 D 1245769 CDS LALA0_S05e01992g 34685742 join(158225..158273,158337..159337) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; uncharacterized protein 159337 34685742 LALA0_S05e01992g Lachancea lanzarotensis uncharacterized protein XP_022628507.1 158225 D 1245769 CDS LALA0_S05e02014g 34685743 complement(159326..160096) Unknown 1 NW_019212883.1 similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens; uncharacterized protein 160096 34685743 LALA0_S05e02014g Lachancea lanzarotensis uncharacterized protein XP_022628508.1 159326 R 1245769 CDS LALA0_S05e02036g 34685744 160280..162460 Unknown 1 NW_019212883.1 similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; lanosterol synthase ERG7 162460 34685744 LALA0_S05e02036g Lachancea lanzarotensis lanosterol synthase ERG7 XP_022628509.1 160280 D 1245769 CDS LALA0_S05e02058g 34685745 complement(162568..164328) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; uncharacterized protein 164328 34685745 LALA0_S05e02058g Lachancea lanzarotensis uncharacterized protein XP_022628510.1 162568 R 1245769 CDS LALA0_S05e02080g 34685746 164660..164833 Unknown 1 NW_019212883.1 highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA; snoRNP complex protein NOP10 164833 34685746 LALA0_S05e02080g Lachancea lanzarotensis snoRNP complex protein NOP10 XP_022628511.1 164660 D 1245769 CDS LALA0_S05e02102g 34685747 complement(165006..165224) Unknown 1 NW_019212883.1 highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 165224 34685747 LALA0_S05e02102g Lachancea lanzarotensis uncharacterized protein XP_022628512.1 165006 R 1245769 CDS LALA0_S05e02124g 34685748 165773..168439 Unknown 1 NW_019212883.1 similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; oxysterol-binding protein related protein OSH3 168439 34685748 LALA0_S05e02124g Lachancea lanzarotensis oxysterol-binding protein related protein OSH3 XP_022628513.1 165773 D 1245769 CDS LALA0_S05e02146g 34685749 168746..169882 Unknown 1 NW_019212883.1 similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase, involved in asparagine catabolism; asparaginase ASP1 169882 34685749 LALA0_S05e02146g Lachancea lanzarotensis asparaginase ASP1 XP_022628514.1 168746 D 1245769 CDS LALA0_S05e02168g 34685750 170139..171170 Unknown 1 NW_019212883.1 highly similar to Lachancea thermotolerans KLTH0H15136g hypothetical protein; uncharacterized protein 171170 34685750 LALA0_S05e02168g Lachancea lanzarotensis uncharacterized protein XP_022628515.1 170139 D 1245769 CDS LALA0_S05e02190g 34685751 171408..173552 Unknown 1 NW_019212883.1 highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; glutamine-dependent NAD(+) synthetase 173552 34685751 LALA0_S05e02190g Lachancea lanzarotensis glutamine-dependent NAD(+) synthetase XP_022628516.1 171408 D 1245769 CDS LALA0_S05e02212g 34685752 complement(173606..174703) Unknown 1 NW_019212883.1 similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; phosphoprotein phosphatase methylesterase 1 174703 34685752 LALA0_S05e02212g Lachancea lanzarotensis phosphoprotein phosphatase methylesterase 1 XP_022628517.1 173606 R 1245769 CDS LALA0_S05e02234g 34685753 176810..177811 Unknown 1 NW_019212883.1 some similarities with uniprot|P38704 Saccharomyces cerevisiae YHR006W (ohnolog of YDR463W) STP2 Transcriptionfactor, activated by proteolytic processing in response tosignals from the SPS sensor system for external aminoacids; activates transcription of amino acid permeasegenes; uncharacterized protein 177811 34685753 LALA0_S05e02234g Lachancea lanzarotensis uncharacterized protein XP_022628518.1 176810 D 1245769 CDS LALA0_S05e02256g 34685754 178378..179715 Unknown 1 NW_019212883.1 similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily; uncharacterized protein 179715 34685754 LALA0_S05e02256g Lachancea lanzarotensis uncharacterized protein XP_022628519.1 178378 D 1245769 CDS LALA0_S05e02322g 34685756 183039..184238 Unknown 1 NW_019212883.1 highly similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader; carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 184238 34685756 LALA0_S05e02322g Lachancea lanzarotensis carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 XP_022628520.1 183039 D 1245769 CDS LALA0_S05e02344g 34685757 185005..189246 Unknown 1 NW_019212883.1 similar to Lachancea thermotolerans KLTH0E02244g hypothetical protein; uncharacterized protein 189246 34685757 LALA0_S05e02344g Lachancea lanzarotensis uncharacterized protein XP_022628521.1 185005 D 1245769 CDS LALA0_S05e02366g 34685758 189648..192722 Unknown 1 NW_019212883.1 similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; DNA translocase 192722 34685758 LALA0_S05e02366g Lachancea lanzarotensis DNA translocase XP_022628522.1 189648 D 1245769 CDS LALA0_S05e02388g 34685759 complement(192748..194253) Unknown 1 NW_019212883.1 similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination; ribonuclease III 194253 34685759 LALA0_S05e02388g Lachancea lanzarotensis ribonuclease III XP_022628523.1 192748 R 1245769 CDS LALA0_S05e02410g 34685760 complement(194893..196413) Unknown 1 NW_019212883.1 similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p; U2 snRNP complex subunit CUS1 196413 34685760 LALA0_S05e02410g Lachancea lanzarotensis U2 snRNP complex subunit CUS1 XP_022628524.1 194893 R 1245769 CDS LALA0_S05e02432g 34685761 complement(196732..196941) Unknown 1 NW_019212883.1 weakly similar to uniprot|O14468 Saccharomyces cerevisiae YOR304C-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; uncharacterized protein 196941 34685761 LALA0_S05e02432g Lachancea lanzarotensis uncharacterized protein XP_022628525.1 196732 R 1245769 CDS LALA0_S05e02454g 34685762 197624..198343 Unknown 1 NW_019212883.1 similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W RRG7 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene; uncharacterized protein 198343 34685762 LALA0_S05e02454g Lachancea lanzarotensis uncharacterized protein XP_022628526.1 197624 D 1245769 CDS LALA0_S05e02476g 34685763 198811..199749 Unknown 1 NW_019212883.1 highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome; uncharacterized protein 199749 34685763 LALA0_S05e02476g Lachancea lanzarotensis uncharacterized protein XP_022628527.1 198811 D 1245769 CDS LALA0_S05e02498g 34685764 complement(199943..201289) Unknown 1 NW_019212883.1 similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 Protein involved in ER-to-Golgi transport; uncharacterized protein 201289 34685764 LALA0_S05e02498g Lachancea lanzarotensis uncharacterized protein XP_022628528.1 199943 R 1245769 CDS LALA0_S05e02542g 34685766 complement(202204..203934) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1; U4/U6-U5 snRNP complex subunit SNU66 203934 34685766 LALA0_S05e02542g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit SNU66 XP_022628529.1 202204 R 1245769 CDS LALA0_S05e02564g 34685767 complement(204372..205922) Unknown 1 NW_019212883.1 similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W NOP56 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects; RNA-processing protein NOP58 205922 34685767 LALA0_S05e02564g Lachancea lanzarotensis RNA-processing protein NOP58 XP_022628530.1 204372 R 1245769 CDS LALA0_S05e02586g 34685768 complement(206787..207689) Unknown 1 NW_019212883.1 similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C DGK1 Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain; diacylglycerol kinase 207689 34685768 LALA0_S05e02586g Lachancea lanzarotensis diacylglycerol kinase XP_022628531.1 206787 R 1245769 CDS LALA0_S05e02608g 34685769 complement(208416..208949) Unknown 1 NW_019212883.1 highly similar to uniprot|P0CX24 Saccharomyces cerevisiae YOR312C (ohnolog of YMR242C) RPL20B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein; 60S ribosomal protein eL20 208949 34685769 LALA0_S05e02608g Lachancea lanzarotensis 60S ribosomal protein eL20 XP_022628532.1 208416 R 1245769 CDS LALA0_S05e02630g 34685770 complement(210102..210956) Unknown 1 NW_019212883.1 weakly similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage; uncharacterized protein 210956 34685770 LALA0_S05e02630g Lachancea lanzarotensis uncharacterized protein XP_022628533.1 210102 R 1245769 CDS LALA0_S05e02652g 34685771 212206..213213 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W SFG1 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate; uncharacterized protein 213213 34685771 LALA0_S05e02652g Lachancea lanzarotensis uncharacterized protein XP_022628534.1 212206 D 1245769 CDS LALA0_S05e02674g 34685772 complement(213541..214854) Unknown 1 NW_019212883.1 similar to uniprot|P32798 Saccharomyces cerevisiae YOR316C (ohnolog of YMR243C) COT1 Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; uncharacterized protein 214854 34685772 LALA0_S05e02674g Lachancea lanzarotensis uncharacterized protein XP_022628535.1 213541 R 1245769 CDS LALA0_S05e02696g 34685773 216979..218022 Unknown 1 NW_019212883.1 similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Putative protein of unknown function; uncharacterized protein 218022 34685773 LALA0_S05e02696g Lachancea lanzarotensis uncharacterized protein XP_022628536.1 216979 D 1245769 CDS LALA0_S05e02718g 34685774 complement(219169..220155) Unknown 1 NW_019212883.1 similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase; uncharacterized protein 220155 34685774 LALA0_S05e02718g Lachancea lanzarotensis uncharacterized protein XP_022628537.1 219169 R 1245769 CDS LALA0_S05e02740g 34685775 complement(221107..221436) Unknown 1 NW_019212883.1 similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene; uncharacterized protein 221436 34685775 LALA0_S05e02740g Lachancea lanzarotensis uncharacterized protein XP_022628538.1 221107 R 1245769 CDS LALA0_S05e02762g 34685776 222806..223147 Unknown 1 NW_019212883.1 similar to uniprot|C5DHA9 Lachancea thermotolerans KLTH0E02794g hypothetical protein; uncharacterized protein 223147 34685776 LALA0_S05e02762g Lachancea lanzarotensis uncharacterized protein XP_022628539.1 222806 D 1245769 CDS LALA0_S05e02784g 34685777 223498..225042 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p; uncharacterized protein 225042 34685777 LALA0_S05e02784g Lachancea lanzarotensis uncharacterized protein XP_022628540.1 223498 D 1245769 CDS LALA0_S05e02828g 34685779 225463..226314 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment; uncharacterized protein 226314 34685779 LALA0_S05e02828g Lachancea lanzarotensis uncharacterized protein XP_022628541.1 225463 D 1245769 CDS LALA0_S05e02850g 34685780 complement(226582..228831) Unknown 1 NW_019212883.1 some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; uncharacterized protein 228831 34685780 LALA0_S05e02850g Lachancea lanzarotensis uncharacterized protein XP_022628542.1 226582 R 1245769 CDS LALA0_S05e02872g 34685781 complement(229920..231869) Unknown 1 NW_019212883.1 similar to uniprot|Q12086 Saccharomyces cerevisiae YDR263C (ohnolog of YOR033C) DIN7 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; uncharacterized protein 231869 34685781 LALA0_S05e02872g Lachancea lanzarotensis uncharacterized protein XP_022628543.1 229920 R 1245769 CDS LALA0_S05e02894g 34685782 complement(232181..234376) Unknown 1 NW_019212883.1 similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C (ohnolog of YOR034C) AKR1 Palmitoyl transferaseinvolved in protein palmitoylation; acts as a negativeregulator of pheromone response pathway; required forendocytosis of pheromone receptors; involved in cell shapecontrol; contains ankyrin repeats; palmitoyltransferase AKR1 234376 34685782 LALA0_S05e02894g Lachancea lanzarotensis palmitoyltransferase AKR1 XP_022628544.1 232181 R 1245769 CDS LALA0_S05e02916g 34685783 complement(235139..237460) Unknown 1 NW_019212883.1 similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization; uncharacterized protein 237460 34685783 LALA0_S05e02916g Lachancea lanzarotensis uncharacterized protein XP_022628545.1 235139 R 1245769 CDS LALA0_S05e02938g 34685784 join(238439..238508,238600..239567) Unknown 1 NW_019212883.1 similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders; ubiquitin-protein ligase peroxin 10 239567 34685784 LALA0_S05e02938g Lachancea lanzarotensis ubiquitin-protein ligase peroxin 10 XP_022628546.1 238439 D 1245769 CDS LALA0_S05e02960g 34685785 complement(239616..241481) Unknown 1 NW_019212883.1 similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain; E3 ubiquitin-protein ligase HEL2 241481 34685785 LALA0_S05e02960g Lachancea lanzarotensis E3 ubiquitin-protein ligase HEL2 XP_022628547.1 239616 R 1245769 CDS LALA0_S05e02982g 34685786 join(241830..242018,242106..242471) Unknown 1 NW_019212883.1 similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C GEP4 Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT; phosphatidylglycerophosphatase 242471 34685786 LALA0_S05e02982g Lachancea lanzarotensis phosphatidylglycerophosphatase XP_022628548.1 241830 D 1245769 CDS LALA0_S05e03004g 34685787 complement(243208..254382) Unknown 1 NW_019212883.1 highly similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; histone acetyltransferase TRA1 254382 34685787 LALA0_S05e03004g Lachancea lanzarotensis histone acetyltransferase TRA1 XP_022628549.1 243208 R 1245769 CDS LALA0_S05e03026g 34685788 complement(255021..256517) Unknown 1 NW_019212883.1 similar to uniprot|P25346 Saccharomyces cerevisiae YCR098C GIT1 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; uncharacterized protein 256517 34685788 LALA0_S05e03026g Lachancea lanzarotensis uncharacterized protein XP_022628550.1 255021 R 1245769 CDS LALA0_S05e03070g 34685790 258042..259814 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum; uncharacterized protein 259814 34685790 LALA0_S05e03070g Lachancea lanzarotensis uncharacterized protein XP_022628551.1 258042 D 1245769 CDS LALA0_S05e03092g 34685791 260182..262860 Unknown 1 NW_019212883.1 similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p; uncharacterized protein 262860 34685791 LALA0_S05e03092g Lachancea lanzarotensis uncharacterized protein XP_022628552.1 260182 D 1245769 CDS LALA0_S05e03114g 34685792 join(263557..263861,264452..265541) Unknown 1 NW_019212883.1 similar to uniprot|P38809 Saccharomyces cerevisiae YHR097C (ohnolog of YDR348C) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; uncharacterized protein 265541 34685792 LALA0_S05e03114g Lachancea lanzarotensis uncharacterized protein XP_022628553.1 263557 D 1245769 CDS LALA0_S05e03136g 34685793 complement(265848..266774) Unknown 1 NW_019212883.1 similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein; mitochondrial 37S ribosomal protein mS43 266774 34685793 LALA0_S05e03136g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS43 XP_022628554.1 265848 R 1245769 CDS LALA0_S05e03180g 34685795 268487..269710 Unknown 1 NW_019212883.1 similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance; uncharacterized protein 269710 34685795 LALA0_S05e03180g Lachancea lanzarotensis uncharacterized protein XP_022628555.1 268487 D 1245769 CDS LALA0_S05e03202g 34685796 271714..273444 Unknown 1 NW_019212883.1 highly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C (ohnolog of YHR096C) HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions; uncharacterized protein 273444 34685796 LALA0_S05e03202g Lachancea lanzarotensis uncharacterized protein XP_022628556.1 271714 D 1245769 CDS LALA0_S05e03224g 34685797 279541..281262 Unknown 1 NW_019212883.1 highly similar to uniprot|P13181 Saccharomyces cerevisiae YLR081W GAL2 Galactose permease, required for utilization of galactose; also able to transport glucose; uncharacterized protein 281262 34685797 LALA0_S05e03224g Lachancea lanzarotensis uncharacterized protein XP_022628557.1 279541 D 1245769 CDS LALA0_S05e03246g 34685798 complement(281444..282283) Unknown 1 NW_019212883.1 weakly similar to uniprot|C5DHB7 Lachancea thermotolerans KLTH0E02992g hypothetical protein; uncharacterized protein 282283 34685798 LALA0_S05e03246g Lachancea lanzarotensis uncharacterized protein XP_022628558.1 281444 R 1245769 CDS LALA0_S05e03268g 34685799 282872..284812 Unknown 1 NW_019212883.1 highly similar to uniprot|P38714 Saccharomyces cerevisiae YHR091C (ohnolog of YDR341C) MSR1 Mitochondrial arginyl-tRNA synthetase; arginine--tRNA ligase 284812 34685799 LALA0_S05e03268g Lachancea lanzarotensis arginine--tRNA ligase XP_022628559.1 282872 D 1245769 CDS LALA0_S05e03312g 34685801 285503..286072 Unknown 1 NW_019212883.1 highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C FCF1 Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p; rRNA-processing protein FCF1 286072 34685801 LALA0_S05e03312g Lachancea lanzarotensis rRNA-processing protein FCF1 XP_022628560.1 285503 D 1245769 CDS LALA0_S05e03334g 34685802 complement(286146..286733) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Putative protein of unknown function, predicted to be palmitoylated; uncharacterized protein 286733 34685802 LALA0_S05e03334g Lachancea lanzarotensis uncharacterized protein XP_022628561.1 286146 R 1245769 CDS LALA0_S05e03356g 34685803 290198..291004 Unknown 1 NW_019212883.1 similar to uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5; histone acetyltransferase YNG2 291004 34685803 LALA0_S05e03356g Lachancea lanzarotensis histone acetyltransferase YNG2 XP_022628562.1 290198 D 1245769 CDS LALA0_S05e03378g 34685804 291262..293316 Unknown 1 NW_019212883.1 similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; uncharacterized protein 293316 34685804 LALA0_S05e03378g Lachancea lanzarotensis uncharacterized protein XP_022628563.1 291262 D 1245769 CDS LALA0_S05e03400g 34685805 293658..295145 Unknown 1 NW_019212883.1 weakly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; uncharacterized protein 295145 34685805 LALA0_S05e03400g Lachancea lanzarotensis uncharacterized protein XP_022628564.1 293658 D 1245769 CDS LALA0_S05e03422g 34685806 complement(295257..296126) Unknown 1 NW_019212883.1 similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS15m 296126 34685806 LALA0_S05e03422g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS15m XP_022628565.1 295257 R 1245769 CDS LALA0_S05e03444g 34685807 complement(296313..299372) Unknown 1 NW_019212883.1 similar to uniprot|C5DHD3 Lachancea thermotolerans KLTH0E03432g hypothetical protein; uncharacterized protein 299372 34685807 LALA0_S05e03444g Lachancea lanzarotensis uncharacterized protein XP_022628566.1 296313 R 1245769 CDS LALA0_S05e03466g 34685808 300522..301187 Unknown 1 NW_019212883.1 similar to uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA; uncharacterized protein 301187 34685808 LALA0_S05e03466g Lachancea lanzarotensis uncharacterized protein XP_022628567.1 300522 D 1245769 CDS LALA0_S05e03488g 34685809 complement(301365..302432) Unknown 1 NW_019212883.1 similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene; uncharacterized protein 302432 34685809 LALA0_S05e03488g Lachancea lanzarotensis uncharacterized protein XP_022628568.1 301365 R 1245769 CDS LALA0_S05e03510g 34685810 complement(302674..306339) Unknown 1 NW_019212883.1 highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; karyopherin MSN5 306339 34685810 LALA0_S05e03510g Lachancea lanzarotensis karyopherin MSN5 XP_022628569.1 302674 R 1245769 CDS LALA0_S05e03532g 34685811 complement(307518..308399) Unknown 1 NW_019212883.1 highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA; rRNA-binding ribosome biosynthesis protein RPF1 308399 34685811 LALA0_S05e03532g Lachancea lanzarotensis rRNA-binding ribosome biosynthesis protein RPF1 XP_022628570.1 307518 R 1245769 CDS LALA0_S05e03554g 34685812 complement(309672..314195) Unknown 1 NW_019212883.1 similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W (ohnolog of YOR153W) PDR15 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; uncharacterized protein 314195 34685812 LALA0_S05e03554g Lachancea lanzarotensis uncharacterized protein XP_022628571.1 309672 R 1245769 CDS LALA0_S05e03576g 34685813 316823..318877 Unknown 1 NW_019212883.1 similar to uniprot|C5DHD3 Lachancea thermotolerans KLTH0E03432g hypothetical protein; uncharacterized protein 318877 34685813 LALA0_S05e03576g Lachancea lanzarotensis uncharacterized protein XP_022628572.1 316823 D 1245769 CDS LALA0_S05e03598g 34685814 complement(319057..319368) Unknown 1 NW_019212883.1 similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W RTC3 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; uncharacterized protein 319368 34685814 LALA0_S05e03598g Lachancea lanzarotensis uncharacterized protein XP_022628573.1 319057 R 1245769 CDS LALA0_S05e03620g 34685815 complement(321146..325576) Unknown 1 NW_019212883.1 similar to uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; chromatin-remodeling protein SWR1 325576 34685815 LALA0_S05e03620g Lachancea lanzarotensis chromatin-remodeling protein SWR1 XP_022628574.1 321146 R 1245769 CDS LALA0_S05e03664g 34685817 complement(327062..328612) Unknown 1 NW_019212883.1 similar to uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre- mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; uncharacterized protein 328612 34685817 LALA0_S05e03664g Lachancea lanzarotensis uncharacterized protein XP_022628575.1 327062 R 1245769 CDS LALA0_S05e03686g 34685818 complement(329690..330775) Unknown 1 NW_019212883.1 similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles; uncharacterized protein 330775 34685818 LALA0_S05e03686g Lachancea lanzarotensis uncharacterized protein XP_022628576.1 329690 R 1245769 CDS LALA0_S05e03708g 34685819 331718..333862 Unknown 1 NW_019212883.1 similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Putative protein of unknown function; uncharacterized protein 333862 34685819 LALA0_S05e03708g Lachancea lanzarotensis uncharacterized protein XP_022628577.1 331718 D 1245769 CDS LALA0_S05e03730g 34685820 complement(333977..336046) Unknown 1 NW_019212883.1 weakly similar to uniprot|P13574 Saccharomyces cerevisiae YHR084W STE12 Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; homeodomain family transcription factor STE12 336046 34685820 LALA0_S05e03730g Lachancea lanzarotensis homeodomain family transcription factor STE12 XP_022628578.1 333977 R 1245769 CDS LALA0_S05e03752g 34685821 complement(336901..337869) Unknown 1 NW_019212883.1 similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane; SAM complex subunit SAM35 337869 34685821 LALA0_S05e03752g Lachancea lanzarotensis SAM complex subunit SAM35 XP_022628579.1 336901 R 1245769 CDS LALA0_S05e03774g 34685822 complement(338410..340422) Unknown 1 NW_019212883.1 similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W IRC3 Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; double-stranded DNA-dependent ATPase 340422 34685822 LALA0_S05e03774g Lachancea lanzarotensis double-stranded DNA-dependent ATPase XP_022628580.1 338410 R 1245769 CDS LALA0_S05e03796g 34685823 341913..344381 Unknown 1 NW_019212883.1 similar to uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; uncharacterized protein 344381 34685823 LALA0_S05e03796g Lachancea lanzarotensis uncharacterized protein XP_022628581.1 341913 D 1245769 CDS LALA0_S05e03818g 34685824 complement(344712..345887) Unknown 1 NW_019212883.1 similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog; GPI-anchor transamidase 345887 34685824 LALA0_S05e03818g Lachancea lanzarotensis GPI-anchor transamidase XP_022628582.1 344712 R 1245769 CDS LALA0_S05e03840g 34685825 complement(346175..347626) Unknown 1 NW_019212883.1 similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; uncharacterized protein 347626 34685825 LALA0_S05e03840g Lachancea lanzarotensis uncharacterized protein XP_022628583.1 346175 R 1245769 CDS LALA0_S05e03862g 34685826 complement(348184..348729) Unknown 1 NW_019212883.1 similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination; uncharacterized protein 348729 34685826 LALA0_S05e03862g Lachancea lanzarotensis uncharacterized protein XP_022628584.1 348184 R 1245769 CDS LALA0_S05e03884g 34685827 349599..350996 Unknown 1 NW_019212883.1 similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p; uncharacterized protein 350996 34685827 LALA0_S05e03884g Lachancea lanzarotensis uncharacterized protein XP_022628585.1 349599 D 1245769 CDS LALA0_S05e03906g 34685828 351670..352218 Unknown 1 NW_019212883.1 highly similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; SCF ubiquitin ligase subunit SKP1 352218 34685828 LALA0_S05e03906g Lachancea lanzarotensis SCF ubiquitin ligase subunit SKP1 XP_022628586.1 351670 D 1245769 CDS LALA0_S05e03928g 34685829 353358..357263 Unknown 1 NW_019212883.1 weakly similar to uniprot|P38800 Saccharomyces cerevisiae YHR080C (ohnolog of YDR326C) Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 357263 34685829 LALA0_S05e03928g Lachancea lanzarotensis uncharacterized protein XP_022628587.1 353358 D 1245769 CDS LALA0_S05e03950g 34685830 join(357547..357665,357740..357908) Unknown 1 NW_019212883.1 similar to uniprot|P89114 Saccharomyces cerevisiae YHR079C-A SAE3 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p; uncharacterized protein 357908 34685830 LALA0_S05e03950g Lachancea lanzarotensis uncharacterized protein XP_022628588.1 357547 D 1245769 CDS LALA0_S05e03972g 34685831 358304..361648 Unknown 1 NW_019212883.1 similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; bifunctional endoribonuclease/protein kinase IRE1 361648 34685831 LALA0_S05e03972g Lachancea lanzarotensis bifunctional endoribonuclease/protein kinase IRE1 XP_022628589.1 358304 D 1245769 CDS LALA0_S05e03994g 34685832 complement(361765..364827) Unknown 1 NW_019212883.1 similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; condensin subunit YCG1 364827 34685832 LALA0_S05e03994g Lachancea lanzarotensis condensin subunit YCG1 XP_022628590.1 361765 R 1245769 CDS LALA0_S05e04016g 34685833 366124..368364 Unknown 1 NW_019212883.1 similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; uncharacterized protein 368364 34685833 LALA0_S05e04016g Lachancea lanzarotensis uncharacterized protein XP_022628591.1 366124 D 1245769 CDS LALA0_S05e04038g 34685834 complement(368381..370015) Unknown 1 NW_019212883.1 similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W High osmolarity-regulated gene of unknown function; uncharacterized protein 370015 34685834 LALA0_S05e04038g Lachancea lanzarotensis uncharacterized protein XP_022628592.1 368381 R 1245769 CDS LALA0_S05e04060g 34685835 370355..371905 Unknown 1 NW_019212883.1 similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance; phosphatidylinositol-3-phosphate binding protein 371905 34685835 LALA0_S05e04060g Lachancea lanzarotensis phosphatidylinositol-3-phosphate binding protein XP_022628593.1 370355 D 1245769 CDS LALA0_S05e04082g 34685836 join(372082..372087,372177..375242) Unknown 1 NW_019212883.1 similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance; uncharacterized protein 375242 34685836 LALA0_S05e04082g Lachancea lanzarotensis uncharacterized protein XP_022628594.1 372082 D 1245769 CDS LALA0_S05e04104g 34685837 complement(375341..376420) Unknown 1 NW_019212883.1 similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; type 2C protein phosphatase PTC7 376420 34685837 LALA0_S05e04104g Lachancea lanzarotensis type 2C protein phosphatase PTC7 XP_022628595.1 375341 R 1245769 CDS LALA0_S05e04126g 34685838 376795..377073 Unknown 1 NW_019212883.1 similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase; F1F0 ATP synthase subunit e 377073 34685838 LALA0_S05e04126g Lachancea lanzarotensis F1F0 ATP synthase subunit e XP_022628596.1 376795 D 1245769 CDS LALA0_S05e04148g 34685839 complement(377271..378347) Unknown 1 NW_019212883.1 similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL38 378347 34685839 LALA0_S05e04148g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL38 XP_022628597.1 377271 R 1245769 CDS LALA0_S05e04170g 34685840 complement(379895..381271) Unknown 1 NW_019212883.1 highly similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p; uncharacterized protein 381271 34685840 LALA0_S05e04170g Lachancea lanzarotensis uncharacterized protein XP_022628598.1 379895 R 1245769 CDS LALA0_S05e04192g 34685841 complement(join(381659..383711,383792..383817)) Unknown 1 NW_019212883.1 similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W (ohnolog of YMR237W) BUD7 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; exomer complex subunit 383817 34685841 LALA0_S05e04192g Lachancea lanzarotensis exomer complex subunit XP_022628599.1 381659 R 1245769 CDS LALA0_S05e04214g 34685842 complement(384233..384661) Unknown 1 NW_019212883.1 similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9 Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3; chromatin modification protein 384661 34685842 LALA0_S05e04214g Lachancea lanzarotensis chromatin modification protein XP_022628600.1 384233 R 1245769 CDS LALA0_S05e04236g 34685843 join(385786..385899,386131..386337) Unknown 1 NW_019212883.1 highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component; ribosomal protein P1 beta 386337 34685843 LALA0_S05e04236g Lachancea lanzarotensis ribosomal protein P1 beta XP_022628601.1 385786 D 1245769 CDS LALA0_S05e04258g 34685844 387111..387734 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; uncharacterized protein 387734 34685844 LALA0_S05e04258g Lachancea lanzarotensis uncharacterized protein XP_022628602.1 387111 D 1245769 CDS LALA0_S05e04280g 34685845 388817..390193 Unknown 1 NW_019212883.1 similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; uncharacterized protein 390193 34685845 LALA0_S05e04280g Lachancea lanzarotensis uncharacterized protein XP_022628603.1 388817 D 1245769 CDS LALA0_S05e04302g 34685846 390802..392019 Unknown 1 NW_019212883.1 highly similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W VCX1 Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; uncharacterized protein 392019 34685846 LALA0_S05e04302g Lachancea lanzarotensis uncharacterized protein XP_022628604.1 390802 D 1245769 CDS LALA0_S05e04324g 34685847 392872..393768 Unknown 1 NW_019212883.1 similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W (ohnolog of YDL179W) PCL2 Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; cyclin PCL2 393768 34685847 LALA0_S05e04324g Lachancea lanzarotensis cyclin PCL2 XP_022628605.1 392872 D 1245769 CDS LALA0_S05e04346g 34685848 complement(394045..396534) Unknown 1 NW_019212883.1 highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase involved in ubiquitin-mediated protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD); along with Npl4-Ufd1 complex, important for maintaining the cell wall integrity during heat stress to allow G1 progression; AAA family ATPase CDC48 396534 34685848 LALA0_S05e04346g Lachancea lanzarotensis AAA family ATPase CDC48 XP_022628606.1 394045 R 1245769 CDS LALA0_S05e04368g 34685849 complement(join(397144..397538,397606..397660)) Unknown 1 NW_019212883.1 similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C HNT1 Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; adenosine 5'-monophosphoramidase 397660 34685849 LALA0_S05e04368g Lachancea lanzarotensis adenosine 5'-monophosphoramidase XP_022628607.1 397144 R 1245769 CDS LALA0_S05e04390g 34685850 398242..399873 Unknown 1 NW_019212883.1 highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase, located in the mitochondrial matrix; D-lactate dehydrogenase 399873 34685850 LALA0_S05e04390g Lachancea lanzarotensis D-lactate dehydrogenase XP_022628608.1 398242 D 1245769 CDS LALA0_S05e04412g 34685851 complement(399973..400470) Unknown 1 NW_019212883.1 similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene; uncharacterized protein 400470 34685851 LALA0_S05e04412g Lachancea lanzarotensis uncharacterized protein XP_022628609.1 399973 R 1245769 CDS LALA0_S05e04434g 34685852 400618..402702 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene; uncharacterized protein 402702 34685852 LALA0_S05e04434g Lachancea lanzarotensis uncharacterized protein XP_022628610.1 400618 D 1245769 CDS LALA0_S05e04456g 34685853 complement(402894..403886) Unknown 1 NW_019212883.1 similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C (ohnolog of YIL079C) AIR2 Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p; uncharacterized protein 403886 34685853 LALA0_S05e04456g Lachancea lanzarotensis uncharacterized protein XP_022628611.1 402894 R 1245769 CDS LALA0_S05e04478g 34685854 404824..407022 Unknown 1 NW_019212883.1 highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase, essential cytoplasmic protein; threonine--tRNA ligase THS1 407022 34685854 LALA0_S05e04478g Lachancea lanzarotensis threonine--tRNA ligase THS1 XP_022628612.1 404824 D 1245769 CDS LALA0_S05e04500g 34685855 complement(407108..408148) Unknown 1 NW_019212883.1 similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); uncharacterized protein 408148 34685855 LALA0_S05e04500g Lachancea lanzarotensis uncharacterized protein XP_022628613.1 407108 R 1245769 CDS LALA0_S05e04522g 34685856 409926..410804 Unknown 1 NW_019212883.1 similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; coatomer subunit epsilon 410804 34685856 LALA0_S05e04522g Lachancea lanzarotensis coatomer subunit epsilon XP_022628614.1 409926 D 1245769 CDS LALA0_S05e04544g 34685857 411072..411992 Unknown 1 NW_019212883.1 similar to uniprot|P40056 Saccharomyces cerevisiae YER083C GET2 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division; GET complex subunit GET2 411992 34685857 LALA0_S05e04544g Lachancea lanzarotensis GET complex subunit GET2 XP_022628615.1 411072 D 1245769 CDS LALA0_S05e04566g 34685858 complement(412062..413387) Unknown 1 NW_019212883.1 highly similar to Lachancea thermotolerans KLTH0A05104g hypothetical protein; uncharacterized protein 413387 34685858 LALA0_S05e04566g Lachancea lanzarotensis uncharacterized protein XP_022628616.1 412062 R 1245769 CDS LALA0_S05e04588g 34685859 415344..415988 Unknown 1 NW_019212883.1 highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); uncharacterized protein 415988 34685859 LALA0_S05e04588g Lachancea lanzarotensis uncharacterized protein XP_022628617.1 415344 D 1245769 CDS LALA0_S05e04610g 34685860 416924..417556 Unknown 1 NW_019212883.1 highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); uncharacterized protein 417556 34685860 LALA0_S05e04610g Lachancea lanzarotensis uncharacterized protein XP_022628618.1 416924 D 1245769 CDS LALA0_S05e04632g 34685861 complement(417987..418334) Unknown 1 NW_019212883.1 highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS14m 418334 34685861 LALA0_S05e04632g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS14m XP_022628619.1 417987 R 1245769 CDS LALA0_S05e04654g 34685862 complement(418365..418496) Unknown 1 NW_019212883.1 hypothetical protein; uncharacterized protein 418496 34685862 LALA0_S05e04654g Lachancea lanzarotensis uncharacterized protein XP_022628620.1 418365 R 1245769 CDS LALA0_S05e04676g 34685863 complement(418619..419422) Unknown 1 NW_019212883.1 highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; phosphoadenylyl-sulfate reductase (thioredoxin) 419422 34685863 LALA0_S05e04676g Lachancea lanzarotensis phosphoadenylyl-sulfate reductase (thioredoxin) XP_022628621.1 418619 R 1245769 CDS LALA0_S05e04698g 34685864 420142..420585 Unknown 1 NW_019212883.1 similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; mediator complex subunit NUT2 420585 34685864 LALA0_S05e04698g Lachancea lanzarotensis mediator complex subunit NUT2 XP_022628622.1 420142 D 1245769 CDS LALA0_S05e04720g 34685865 420936..422516 Unknown 1 NW_019212883.1 similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; uncharacterized protein 422516 34685865 LALA0_S05e04720g Lachancea lanzarotensis uncharacterized protein XP_022628623.1 420936 D 1245769 CDS LALA0_S05e04764g 34685867 423052..424584 Unknown 1 NW_019212883.1 similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; divalent metal ion transporter SMF1 424584 34685867 LALA0_S05e04764g Lachancea lanzarotensis divalent metal ion transporter SMF1 XP_022628624.1 423052 D 1245769 CDS LALA0_S05e04786g 34685868 complement(424789..426537) Unknown 1 NW_019212883.1 similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; uncharacterized protein 426537 34685868 LALA0_S05e04786g Lachancea lanzarotensis uncharacterized protein XP_022628625.1 424789 R 1245769 CDS LALA0_S05e04808g 34685869 427554..428867 Unknown 1 NW_019212883.1 highly similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C TRM11 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; tRNA (guanine-N2-)-methyltransferase 428867 34685869 LALA0_S05e04808g Lachancea lanzarotensis tRNA (guanine-N2-)-methyltransferase XP_022628626.1 427554 D 1245769 CDS LALA0_S05e04830g 34685870 complement(428969..430237) Unknown 1 NW_019212883.1 similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells; Rab family GTPase YPT11 430237 34685870 LALA0_S05e04830g Lachancea lanzarotensis Rab family GTPase YPT11 XP_022628627.1 428969 R 1245769 CDS LALA0_S05e04852g 34685871 complement(430575..431939) Unknown 1 NW_019212883.1 similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W TRM13 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases; tRNA:m4X modification enzyme 431939 34685871 LALA0_S05e04852g Lachancea lanzarotensis tRNA:m4X modification enzyme XP_022628628.1 430575 R 1245769 CDS LALA0_S05e04874g 34685872 433683..434822 Unknown 1 NW_019212883.1 similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; malate dehydrogenase MDH2 434822 34685872 LALA0_S05e04874g Lachancea lanzarotensis malate dehydrogenase MDH2 XP_022628629.1 433683 D 1245769 CDS LALA0_S05e04896g 34685873 435562..436494 Unknown 1 NW_019212883.1 similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p; uncharacterized protein 436494 34685873 LALA0_S05e04896g Lachancea lanzarotensis uncharacterized protein XP_022628630.1 435562 D 1245769 CDS LALA0_S05e04918g 34685874 complement(join(436610..437025,437448..437460)) Unknown 1 NW_019212883.1 highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W RPL25 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 25S rRNA via a conserved C-terminal motif; 60S ribosomal protein uL23 437460 34685874 LALA0_S05e04918g Lachancea lanzarotensis 60S ribosomal protein uL23 XP_022628631.1 436610 R 1245769 CDS LALA0_S05e04940g 34685875 complement(438287..438934) Unknown 1 NW_019212883.1 similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins; mitochondrial 37S ribosomal protein uS11m 438934 34685875 LALA0_S05e04940g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS11m XP_022628632.1 438287 R 1245769 CDS LALA0_S05e04962g 34685876 440477..441574 Unknown 1 NW_019212883.1 highly similar to uniprot|Q12222 Saccharomyces cerevisiae YOL128C (ohnolog of YNL307C) YGK3 Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; serine/threonine/tyrosine protein kinase MCK1 441574 34685876 LALA0_S05e04962g Lachancea lanzarotensis serine/threonine/tyrosine protein kinase MCK1 XP_022628633.1 440477 D 1245769 CDS LALA0_S05e04984g 34685877 complement(442110..442640) Unknown 1 NW_019212883.1 highly similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68 Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria; uncharacterized protein 442640 34685877 LALA0_S05e04984g Lachancea lanzarotensis uncharacterized protein XP_022628634.1 442110 R 1245769 CDS LALA0_S05e05006g 34685878 444264..445937 Unknown 1 NW_019212883.1 similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p; uncharacterized protein 445937 34685878 LALA0_S05e05006g Lachancea lanzarotensis uncharacterized protein XP_022628635.1 444264 D 1245769 CDS LALA0_S05e05028g 34685879 complement(446089..448452) Unknown 1 NW_019212883.1 similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Mg(2+) transporter ALR1 448452 34685879 LALA0_S05e05028g Lachancea lanzarotensis Mg(2+) transporter ALR1 XP_022628636.1 446089 R 1245769 CDS LALA0_S05e05050g 34685880 complement(449265..450167) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q08270 Saccharomyces cerevisiae YOL131W (ohnolog of YNL309W) Putative protein of unknown function; uncharacterized protein 450167 34685880 LALA0_S05e05050g Lachancea lanzarotensis uncharacterized protein XP_022628637.1 449265 R 1245769 CDS LALA0_S05e05072g 34685881 450353..450904 Unknown 1 NW_019212883.1 similar to uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; uncharacterized protein 450904 34685881 LALA0_S05e05072g Lachancea lanzarotensis uncharacterized protein XP_022628638.1 450353 D 1245769 CDS LALA0_S05e05094g 34685882 451282..453399 Unknown 1 NW_019212883.1 similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C SKP2 F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments; uncharacterized protein 453399 34685882 LALA0_S05e05094g Lachancea lanzarotensis uncharacterized protein XP_022628639.1 451282 D 1245769 CDS LALA0_S05e05116g 34685883 complement(453448..454929) Unknown 1 NW_019212883.1 similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall; 1,3-beta-glucanosyltransferase 454929 34685883 LALA0_S05e05116g Lachancea lanzarotensis 1,3-beta-glucanosyltransferase XP_022628640.1 453448 R 1245769 CDS LALA0_S05e05138g 34685884 complement(join(455161..456023,456106..456112)) Unknown 1 NW_019212883.1 similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; uncharacterized protein 456112 34685884 LALA0_S05e05138g Lachancea lanzarotensis uncharacterized protein XP_022628641.1 455161 R 1245769 CDS LALA0_S05e05160g 34685885 456951..459674 Unknown 1 NW_019212883.1 similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C EMW1 Essential conserved protein with a role in maintaining cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; tetratricopeptide repeat-containing protein EMW1 459674 34685885 LALA0_S05e05160g Lachancea lanzarotensis tetratricopeptide repeat-containing protein EMW1 XP_022628642.1 456951 D 1245769 CDS LALA0_S05e05182g 34685886 complement(459792..460652) Unknown 1 NW_019212883.1 weakly similar to uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain; uncharacterized protein 460652 34685886 LALA0_S05e05182g Lachancea lanzarotensis uncharacterized protein XP_022628643.1 459792 R 1245769 CDS LALA0_S05e05204g 34685887 461456..462469 Unknown 1 NW_019212883.1 similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; uncharacterized protein 462469 34685887 LALA0_S05e05204g Lachancea lanzarotensis uncharacterized protein XP_022628644.1 461456 D 1245769 CDS LALA0_S05e05226g 34685888 462704..463723 Unknown 1 NW_019212883.1 similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway; prephenate dehydratase PHA2 463723 34685888 LALA0_S05e05226g Lachancea lanzarotensis prephenate dehydratase PHA2 XP_022628645.1 462704 D 1245769 CDS LALA0_S05e05248g 34685889 complement(463985..464365) Unknown 1 NW_019212883.1 highly similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; SCF ubiquitin ligase complex subunit HRT1 464365 34685889 LALA0_S05e05248g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit HRT1 XP_022628646.1 463985 R 1245769 CDS LALA0_S05e05270g 34685890 465579..466202 Unknown 1 NW_019212883.1 similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C MED7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; mediator complex subunit MED7 466202 34685890 LALA0_S05e05270g Lachancea lanzarotensis mediator complex subunit MED7 XP_022628647.1 465579 D 1245769 CDS LALA0_S05e05292g 34685891 467122..468390 Unknown 1 NW_019212883.1 similar to uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A; 6-phosphofructo-2-kinase 468390 34685891 LALA0_S05e05292g Lachancea lanzarotensis 6-phosphofructo-2-kinase XP_022628648.1 467122 D 1245769 CDS LALA0_S05e05314g 34685892 complement(468545..469900) Unknown 1 NW_019212883.1 similar to uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex; cleavage polyadenylation factor subunit PFS2 469900 34685892 LALA0_S05e05314g Lachancea lanzarotensis cleavage polyadenylation factor subunit PFS2 XP_022628649.1 468545 R 1245769 CDS LALA0_S05e05336g 34685893 complement(470453..471829) Unknown 1 NW_019212883.1 similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; uncharacterized protein 471829 34685893 LALA0_S05e05336g Lachancea lanzarotensis uncharacterized protein XP_022628650.1 470453 R 1245769 CDS LALA0_S05e05358g 34685894 473380..474183 Unknown 1 NW_019212883.1 similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W LCL3 Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS; uncharacterized protein 474183 34685894 LALA0_S05e05358g Lachancea lanzarotensis uncharacterized protein XP_022628651.1 473380 D 1245769 CDS LALA0_S05e05380g 34685895 complement(474220..475992) Unknown 1 NW_019212883.1 similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C (ohnolog of YPL189W) GUP1 Plasma membrane proteininvolved in remodeling GPI anchors; member of the MBOATfamily of putative membrane-bound O-acyltransferases;proposed to be involved in glycerol transport; uncharacterized protein 475992 34685895 LALA0_S05e05380g Lachancea lanzarotensis uncharacterized protein XP_022628652.1 474220 R 1245769 CDS LALA0_S05e05402g 34685896 477472..478233 Unknown 1 NW_019212883.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 478233 34685896 LALA0_S05e05402g Lachancea lanzarotensis uncharacterized protein XP_022628653.1 477472 D 1245769 CDS LALA0_S05e05446g 34685898 479178..481595 Unknown 1 NW_019212883.1 similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase; uncharacterized protein 481595 34685898 LALA0_S05e05446g Lachancea lanzarotensis uncharacterized protein XP_022628654.1 479178 D 1245769 CDS LALA0_S05e05468g 34685899 482131..482328 Unknown 1 NW_019212883.1 similar to uniprot|Q3E823 Saccharomyces cerevisiae YPL189C-A COA2 Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p; uncharacterized protein 482328 34685899 LALA0_S05e05468g Lachancea lanzarotensis uncharacterized protein XP_022628655.1 482131 D 1245769 CDS LALA0_S05e05490g 34685900 482993..485395 Unknown 1 NW_019212883.1 similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p; uncharacterized protein 485395 34685900 LALA0_S05e05490g Lachancea lanzarotensis uncharacterized protein XP_022628656.1 482993 D 1245769 CDS LALA0_S05e05512g 34685901 485480..485938 Unknown 1 NW_019212883.1 hypothetical protein; uncharacterized protein 485938 34685901 LALA0_S05e05512g Lachancea lanzarotensis uncharacterized protein XP_022628657.1 485480 D 1245769 CDS LALA0_S05e05534g 34685902 486212..487336 Unknown 1 NW_019212883.1 similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W (ohnolog of YPL191C) Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene; uncharacterized protein 487336 34685902 LALA0_S05e05534g Lachancea lanzarotensis uncharacterized protein XP_022628658.1 486212 D 1245769 CDS LALA0_S05e05556g 34685903 487852..489066 Unknown 1 NW_019212883.1 weakly similar to uniprot|P53156 Saccharomyces cerevisiae YGL081W Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis; uncharacterized protein 489066 34685903 LALA0_S05e05556g Lachancea lanzarotensis uncharacterized protein XP_022628659.1 487852 D 1245769 CDS LALA0_S05e05578g 34685904 complement(489723..490745) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly; uncharacterized protein 490745 34685904 LALA0_S05e05578g Lachancea lanzarotensis uncharacterized protein XP_022628660.1 489723 R 1245769 CDS LALA0_S05e05600g 34685905 491473..491871 Unknown 1 NW_019212883.1 similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37 Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; pyruvate transporter MPC1 491871 34685905 LALA0_S05e05600g Lachancea lanzarotensis pyruvate transporter MPC1 XP_022628661.1 491473 D 1245769 CDS LALA0_S05e05622g 34685906 complement(491967..493613) Unknown 1 NW_019212883.1 similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; uncharacterized protein 493613 34685906 LALA0_S05e05622g Lachancea lanzarotensis uncharacterized protein XP_022628662.1 491967 R 1245769 CDS LALA0_S05e05644g 34685907 complement(493840..496647) Unknown 1 NW_019212883.1 similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; uncharacterized protein 496647 34685907 LALA0_S05e05644g Lachancea lanzarotensis uncharacterized protein XP_022628663.1 493840 R 1245769 CDS LALA0_S05e05666g 34685908 496841..497386 Unknown 1 NW_019212883.1 weakly similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W KXD1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome; uncharacterized protein 497386 34685908 LALA0_S05e05666g Lachancea lanzarotensis uncharacterized protein XP_022628664.1 496841 D 1245769 CDS LALA0_S05e05688g 34685909 complement(497526..498248) Unknown 1 NW_019212883.1 similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes; uncharacterized protein 498248 34685909 LALA0_S05e05688g Lachancea lanzarotensis uncharacterized protein XP_022628665.1 497526 R 1245769 CDS LALA0_S05e05710g 34685910 complement(499352..500959) Unknown 1 NW_019212883.1 similar to uniprot|C5E2F3 Lachancea thermotolerans KLTH0H04488g hypothetical protein; uncharacterized protein 500959 34685910 LALA0_S05e05710g Lachancea lanzarotensis uncharacterized protein XP_022628666.1 499352 R 1245769 CDS LALA0_S05e05732g 34685911 complement(501521..503158) Unknown 1 NW_019212883.1 highly similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; RNA-dependent ATPase DBP3 503158 34685911 LALA0_S05e05732g Lachancea lanzarotensis RNA-dependent ATPase DBP3 XP_022628667.1 501521 R 1245769 CDS LALA0_S05e05754g 34685912 complement(503884..505488) Unknown 1 NW_019212883.1 similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; uncharacterized protein 505488 34685912 LALA0_S05e05754g Lachancea lanzarotensis uncharacterized protein XP_022628668.1 503884 R 1245769 CDS LALA0_S05e05776g 34685913 complement(join(506311..506940,507273..507366,507839..507972)) Unknown 1 NW_019212883.1 highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C (ohnolog of YPL198W) RPL7A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); 60S ribosomal uL30 domain-containing protein 507972 34685913 LALA0_S05e05776g Lachancea lanzarotensis 60S ribosomal uL30 domain-containing protein XP_022628669.1 506311 R 1245769 CDS LALA0_S05e05798g 34685914 complement(509299..510141) Unknown 1 NW_019212883.1 hypothetical protein; uncharacterized protein 510141 34685914 LALA0_S05e05798g Lachancea lanzarotensis uncharacterized protein XP_022628670.1 509299 R 1245769 CDS LALA0_S05e05820g 34685915 512930..513706 Unknown 1 NW_019212883.1 similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Putative protein of unknown function, predicted to be palmitoylated; uncharacterized protein 513706 34685915 LALA0_S05e05820g Lachancea lanzarotensis uncharacterized protein XP_022628671.1 512930 D 1245769 CDS LALA0_S05e05842g 34685916 complement(513776..514948) Unknown 1 NW_019212883.1 weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C (ohnolog of YPL200W CSM4) MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p; uncharacterized protein 514948 34685916 LALA0_S05e05842g Lachancea lanzarotensis uncharacterized protein XP_022628672.1 513776 R 1245769 CDS LALA0_S05e05864g 34685917 516145..517965 Unknown 1 NW_019212883.1 weakly similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated; stress-responsive transcription factor HSF1 517965 34685917 LALA0_S05e05864g Lachancea lanzarotensis stress-responsive transcription factor HSF1 XP_022628673.1 516145 D 1245769 CDS LALA0_S05e05886g 34685918 518450..519535 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q08956 Saccharomyces cerevisiae YPL201C YIG1 Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol; uncharacterized protein 519535 34685918 LALA0_S05e05886g Lachancea lanzarotensis uncharacterized protein XP_022628674.1 518450 D 1245769 CDS LALA0_S05e05908g 34685919 520016..521563 Unknown 1 NW_019212883.1 weakly similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W (ohnolog of YPL202C) AFT1 Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; uncharacterized protein 521563 34685919 LALA0_S05e05908g Lachancea lanzarotensis uncharacterized protein XP_022628675.1 520016 D 1245769 CDS LALA0_S05e05930g 34685920 complement(521729..522097) Unknown 1 NW_019212883.1 highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription; DNA-directed RNA polymerase II core subunit RPB9 522097 34685920 LALA0_S05e05930g Lachancea lanzarotensis DNA-directed RNA polymerase II core subunit RPB9 XP_022628676.1 521729 R 1245769 CDS LALA0_S05e05952g 34685921 523522..524037 Unknown 1 NW_019212883.1 similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth; mitochondrial 54S ribosomal protein bL12m 524037 34685921 LALA0_S05e05952g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL12m XP_022628677.1 523522 D 1245769 CDS LALA0_S05e05974g 34685922 complement(524268..525326) Unknown 1 NW_019212883.1 highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; cAMP-dependent protein kinase catalytic subunit TPK2 525326 34685922 LALA0_S05e05974g Lachancea lanzarotensis cAMP-dependent protein kinase catalytic subunit TPK2 XP_022628678.1 524268 R 1245769 CDS LALA0_S05e05996g 34685923 complement(525965..527482) Unknown 1 NW_019212883.1 similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta); serine/threonine protein kinase HRR25 527482 34685923 LALA0_S05e05996g Lachancea lanzarotensis serine/threonine protein kinase HRR25 XP_022628679.1 525965 R 1245769 CDS LALA0_S05e06018g 34685924 531091..532176 Unknown 1 NW_019212883.1 similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; NAD(+) diphosphatase 532176 34685924 LALA0_S05e06018g Lachancea lanzarotensis NAD(+) diphosphatase XP_022628680.1 531091 D 1245769 CDS LALA0_S05e06040g 34685925 532426..533391 Unknown 1 NW_019212883.1 similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C PGC1 Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs; phosphatidylglycerol phospholipase 533391 34685925 LALA0_S05e06040g Lachancea lanzarotensis phosphatidylglycerol phospholipase XP_022628681.1 532426 D 1245769 CDS LALA0_S05e06062g 34685926 534233..535882 Unknown 1 NW_019212883.1 similar to uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; deubiquitination module subunit SGF73 535882 34685926 LALA0_S05e06062g Lachancea lanzarotensis deubiquitination module subunit SGF73 XP_022628682.1 534233 D 1245769 CDS LALA0_S05e06084g 34685927 complement(535950..537485) Unknown 1 NW_019212883.1 similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase 537485 34685927 LALA0_S05e06084g Lachancea lanzarotensis GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase XP_022628683.1 535950 R 1245769 CDS LALA0_S05e06106g 34685928 537615..538823 Unknown 1 NW_019212883.1 similar to uniprot|C5E2D5 Lachancea thermotolerans KLTH0H04048g hypothetical protein; uncharacterized protein 538823 34685928 LALA0_S05e06106g Lachancea lanzarotensis uncharacterized protein XP_022628684.1 537615 D 1245769 CDS LALA0_S05e06128g 34685929 complement(538916..541249) Unknown 1 NW_019212883.1 similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W TYW1 Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; uncharacterized protein 541249 34685929 LALA0_S05e06128g Lachancea lanzarotensis uncharacterized protein XP_022628685.1 538916 R 1245769 CDS LALA0_S05e06150g 34685930 complement(541490..543253) Unknown 1 NW_019212883.1 similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W RKM1 SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B); protein-lysine N-methyltransferase 543253 34685930 LALA0_S05e06150g Lachancea lanzarotensis protein-lysine N-methyltransferase XP_022628686.1 541490 R 1245769 CDS LALA0_S05e06172g 34685931 544149..545303 Unknown 1 NW_019212883.1 similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; aurora kinase 545303 34685931 LALA0_S05e06172g Lachancea lanzarotensis aurora kinase XP_022628687.1 544149 D 1245769 CDS LALA0_S05e06194g 34685932 complement(545346..547004) Unknown 1 NW_019212883.1 similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function; ATP-dependent RNA helicase 547004 34685932 LALA0_S05e06194g Lachancea lanzarotensis ATP-dependent RNA helicase XP_022628688.1 545346 R 1245769 CDS LALA0_S05e06216g 34685933 547200..549005 Unknown 1 NW_019212883.1 similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; signal recognition particle subunit SRP72 549005 34685933 LALA0_S05e06216g Lachancea lanzarotensis signal recognition particle subunit SRP72 XP_022628689.1 547200 D 1245769 CDS LALA0_S05e06238g 34685934 complement(549189..549734) Unknown 1 NW_019212883.1 highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p; ribosome biosynthesis protein NIP7 549734 34685934 LALA0_S05e06238g Lachancea lanzarotensis ribosome biosynthesis protein NIP7 XP_022628690.1 549189 R 1245769 CDS LALA0_S05e06260g 34685935 join(550742..550893,550975..552457) Unknown 1 NW_019212883.1 similar to uniprot|P53167 Saccharomyces cerevisiae YGL063W (ohnolog of YPL212C) PUS2 Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; uncharacterized protein 552457 34685935 LALA0_S05e06260g Lachancea lanzarotensis uncharacterized protein XP_022628691.1 550742 D 1245769 CDS LALA0_S05e06282g 34685936 553090..554412 Unknown 1 NW_019212883.1 similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p; mitochondrial 37S ribosomal protein mS29 554412 34685936 LALA0_S05e06282g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS29 XP_022628692.1 553090 D 1245769 CDS LALA0_S05e06304g 34685937 complement(554488..555903) Unknown 1 NW_019212883.1 similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; mRNA guanylyltransferase 555903 34685937 LALA0_S05e06304g Lachancea lanzarotensis mRNA guanylyltransferase XP_022628693.1 554488 R 1245769 CDS LALA0_S05e06326g 34685938 557767..562224 Unknown 1 NW_019212883.1 similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters; DNA-binding E3 ubiquitin-protein ligase SNT2 562224 34685938 LALA0_S05e06326g Lachancea lanzarotensis DNA-binding E3 ubiquitin-protein ligase SNT2 XP_022628694.1 557767 D 1245769 CDS LALA0_S05e06348g 34685939 complement(562290..563012) Unknown 1 NW_019212883.1 similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; U2 snRNP complex subunit LEA1 563012 34685939 LALA0_S05e06348g Lachancea lanzarotensis U2 snRNP complex subunit LEA1 XP_022628695.1 562290 R 1245769 CDS LALA0_S05e06370g 34685940 564722..566335 Unknown 1 NW_019212883.1 similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase 566335 34685940 LALA0_S05e06370g Lachancea lanzarotensis bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase XP_022628696.1 564722 D 1245769 CDS LALA0_S05e06392g 34685941 complement(566394..567407) Unknown 1 NW_019212883.1 similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; uncharacterized protein 567407 34685941 LALA0_S05e06392g Lachancea lanzarotensis uncharacterized protein XP_022628697.1 566394 R 1245769 CDS LALA0_S05e06414g 34685942 complement(567654..570908) Unknown 1 NW_019212883.1 similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W (ohnolog of YPL216W) ITC1 Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; uncharacterized protein 570908 34685942 LALA0_S05e06414g Lachancea lanzarotensis uncharacterized protein XP_022628698.1 567654 R 1245769 CDS LALA0_S05e06436g 34685943 571752..575261 Unknown 1 NW_019212883.1 highly similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p; GTPase BMS1 575261 34685943 LALA0_S05e06436g Lachancea lanzarotensis GTPase BMS1 XP_022628699.1 571752 D 1245769 CDS LALA0_S05e06458g 34685944 complement(join(575393..575937,576058..576079)) Unknown 1 NW_019212883.1 highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport; Arf family GTPase SAR1 576079 34685944 LALA0_S05e06458g Lachancea lanzarotensis Arf family GTPase SAR1 XP_022628700.1 575393 R 1245769 CDS LALA0_S05e06480g 34685945 complement(576739..578184) Unknown 1 NW_019212883.1 weakly similar to uniprot|P53124 Saccharomyces cerevisiae YGL134W (ohnolog of YPL219W) PCL10 Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; uncharacterized protein 578184 34685945 LALA0_S05e06480g Lachancea lanzarotensis uncharacterized protein XP_022628701.1 576739 R 1245769 CDS LALA0_S05e06502g 34685946 complement(578499..579152) Unknown 1 NW_019212883.1 highly similar to uniprot|P0CX44 Saccharomyces cerevisiae YGL135W (ohnolog of YPL220W) RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal; 60S ribosomal protein uL1 579152 34685946 LALA0_S05e06502g Lachancea lanzarotensis 60S ribosomal protein uL1 XP_022628702.1 578499 R 1245769 CDS LALA0_S05e06524g 34685947 580051..580968 Unknown 1 NW_019212883.1 similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ; 21S rRNA (uridine2791-2'-O) methyltransferase 580968 34685947 LALA0_S05e06524g Lachancea lanzarotensis 21S rRNA (uridine2791-2'-O) methyltransferase XP_022628703.1 580051 D 1245769 CDS LALA0_S05e06546g 34685948 complement(join(581086..583662,583871..583888)) Unknown 1 NW_019212883.1 highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP; coatomer subunit beta' 583888 34685948 LALA0_S05e06546g Lachancea lanzarotensis coatomer subunit beta' XP_022628704.1 581086 R 1245769 CDS LALA0_S05e06568g 34685949 584205..585416 Unknown 1 NW_019212883.1 weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C Putative protein of unknown function; has no significant sequence similarity to any known protein; uncharacterized protein 585416 34685949 LALA0_S05e06568g Lachancea lanzarotensis uncharacterized protein XP_022628705.1 584205 D 1245769 CDS LALA0_S05e06590g 34685950 complement(585974..588421) Unknown 1 NW_019212883.1 similar to uniprot|P53121 Saccharomyces cerevisiae YGL139W (ohnolog of YPL221W) FLC3 Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; uncharacterized protein 588421 34685950 LALA0_S05e06590g Lachancea lanzarotensis uncharacterized protein XP_022628706.1 585974 R 1245769 CDS LALA0_S05e06612g 34685951 complement(588991..591915) Unknown 1 NW_019212883.1 weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; uncharacterized protein 591915 34685951 LALA0_S05e06612g Lachancea lanzarotensis uncharacterized protein XP_022628707.1 588991 R 1245769 CDS LALA0_S05e06634g 34685952 complement(592288..594285) Unknown 1 NW_019212883.1 similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 594285 34685952 LALA0_S05e06634g Lachancea lanzarotensis uncharacterized protein XP_022628708.1 592288 R 1245769 CDS LALA0_S05e06656g 34685953 595501..597327 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q03213 Saccharomyces cerevisiae YMR172W HOT1 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p; uncharacterized protein 597327 34685953 LALA0_S05e06656g Lachancea lanzarotensis uncharacterized protein XP_022628709.1 595501 D 1245769 CDS LALA0_S05e06678g 34685954 598402..600744 Unknown 1 NW_019212883.1 some similarities with uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; DNA damage-responsive protein 48 600744 34685954 LALA0_S05e06678g Lachancea lanzarotensis DNA damage-responsive protein 48 XP_022628710.1 598402 D 1245769 CDS LALA0_S05e06700g 34685955 complement(601260..601778) Unknown 1 NW_019212883.1 hypothetical protein; uncharacterized protein 601778 34685955 LALA0_S05e06700g Lachancea lanzarotensis uncharacterized protein XP_022628711.1 601260 R 1245769 CDS LALA0_S05e06722g 34685956 603014..603436 Unknown 1 NW_019212883.1 similar to Lachancea thermotolerans KLTH0H03212g hypothetical protein; uncharacterized protein 603436 34685956 LALA0_S05e06722g Lachancea lanzarotensis uncharacterized protein XP_022628712.1 603014 D 1245769 CDS LALA0_S05e06744g 34685957 604648..609054 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; uncharacterized protein 609054 34685957 LALA0_S05e06744g Lachancea lanzarotensis uncharacterized protein XP_022628713.1 604648 D 1245769 CDS LALA0_S05e06766g 34685958 609397..610914 Unknown 1 NW_019212883.1 similar to uniprot|Q08970 Saccharomyces cerevisiae YPL224C (ohnolog of YMR177W) MMT2 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p; uncharacterized protein 610914 34685958 LALA0_S05e06766g Lachancea lanzarotensis uncharacterized protein XP_022628714.1 609397 D 1245769 CDS LALA0_S05e06788g 34685959 complement(611012..611452) Unknown 1 NW_019212883.1 highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ribosome-associated Tef1p biogenesis chaperone CHP1 611452 34685959 LALA0_S05e06788g Lachancea lanzarotensis ribosome-associated Tef1p biogenesis chaperone CHP1 XP_022628715.1 611012 R 1245769 CDS LALA0_S05e06810g 34685960 611910..612797 Unknown 1 NW_019212883.1 similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene; uncharacterized protein 612797 34685960 LALA0_S05e06810g Lachancea lanzarotensis uncharacterized protein XP_022628716.1 611910 D 1245769 CDS LALA0_S05e06832g 34685961 complement(612980..616471) Unknown 1 NW_019212883.1 highly similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; uncharacterized protein 616471 34685961 LALA0_S05e06832g Lachancea lanzarotensis uncharacterized protein XP_022628717.1 612980 R 1245769 CDS LALA0_S05e06854g 34685962 617409..619415 Unknown 1 NW_019212883.1 weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; uncharacterized protein 619415 34685962 LALA0_S05e06854g Lachancea lanzarotensis uncharacterized protein XP_022628718.1 617409 D 1245769 CDS LALA0_S05e06876g 34685963 619780..620778 Unknown 1 NW_019212883.1 similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum; dolichyl-phosphate beta-glucosyltransferase 620778 34685963 LALA0_S05e06876g Lachancea lanzarotensis dolichyl-phosphate beta-glucosyltransferase XP_022628719.1 619780 D 1245769 CDS LALA0_S05e06898g 34685964 complement(620901..622451) Unknown 1 NW_019212883.1 similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W (ohnolog of YMR180C) CET1 Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; polynucleotide 5'-phosphatase 622451 34685964 LALA0_S05e06898g Lachancea lanzarotensis polynucleotide 5'-phosphatase XP_022628720.1 620901 R 1245769 CDS LALA0_S05e06920g 34685965 complement(623786..624187) Unknown 1 NW_019212883.1 similar to uniprot|C5E284 Lachancea thermotolerans KLTH0H02904g hypothetical protein; uncharacterized protein 624187 34685965 LALA0_S05e06920g Lachancea lanzarotensis uncharacterized protein XP_022628721.1 623786 R 1245769 CDS LALA0_S05e06942g 34685966 complement(624778..630462) Unknown 1 NW_019212883.1 highly similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acidsynthetase, which catalyzes the synthesis of long-chainsaturated fatty acids; contains the acyl-carrier proteindomain and beta-ketoacyl reductase, beta-ketoacyl synthaseand self-pantetheinylation activities; trifunctional fatty acid synthase subunit FAS2 630462 34685966 LALA0_S05e06942g Lachancea lanzarotensis trifunctional fatty acid synthase subunit FAS2 XP_022628722.1 624778 R 1245769 CDS LALA0_S05e06964g 34685967 complement(632084..632959) Unknown 1 NW_019212883.1 highly similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W (ohnolog of YMR183C) SSO1 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; syntaxin 632959 34685967 LALA0_S05e06964g Lachancea lanzarotensis syntaxin XP_022628723.1 632084 R 1245769 CDS LALA0_S05e06986g 34685968 complement(633497..634138) Unknown 1 NW_019212883.1 similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; MIND complex subunit NSL1 634138 34685968 LALA0_S05e06986g Lachancea lanzarotensis MIND complex subunit NSL1 XP_022628724.1 633497 R 1245769 CDS LALA0_S05e07008g 34685969 634654..635148 Unknown 1 NW_019212883.1 highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C VMA11 Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen; H(+)-transporting V0 sector ATPase subunit c' 635148 34685969 LALA0_S05e07008g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit c' XP_022628725.1 634654 D 1245769 CDS LALA0_S05e07030g 34685970 complement(635333..636745) Unknown 1 NW_019212883.1 highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family; RuvB family ATP-dependent DNA helicase reptin 636745 34685970 LALA0_S05e07030g Lachancea lanzarotensis RuvB family ATP-dependent DNA helicase reptin XP_022628726.1 635333 R 1245769 CDS LALA0_S05e07052g 34685971 637357..638394 Unknown 1 NW_019212883.1 similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Putative protein of unknown function; uncharacterized protein 638394 34685971 LALA0_S05e07052g Lachancea lanzarotensis uncharacterized protein XP_022628727.1 637357 D 1245769 CDS LALA0_S05e07074g 34685972 638520..639044 Unknown 1 NW_019212883.1 similar to uniprot|Q03233 Saccharomyces cerevisiae YMR184W ADD37 Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; uncharacterized protein 639044 34685972 LALA0_S05e07074g Lachancea lanzarotensis uncharacterized protein XP_022628728.1 638520 D 1245769 CDS LALA0_S05e07096g 34685973 complement(639365..640267) Unknown 1 NW_019212883.1 highly similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding; translation initiation factor eIF2 subunit beta 640267 34685973 LALA0_S05e07096g Lachancea lanzarotensis translation initiation factor eIF2 subunit beta XP_022628729.1 639365 R 1245769 CDS LALA0_S05e07118g 34685974 complement(640737..641351) Unknown 1 NW_019212883.1 similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1 Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock; uncharacterized protein 641351 34685974 LALA0_S05e07118g Lachancea lanzarotensis uncharacterized protein XP_022628730.1 640737 R 1245769 CDS LALA0_S05e07140g 34685975 642574..645549 Unknown 1 NW_019212883.1 similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; uncharacterized protein 645549 34685975 LALA0_S05e07140g Lachancea lanzarotensis uncharacterized protein XP_022628731.1 642574 D 1245769 CDS LALA0_S05e07162g 34685976 645921..648035 Unknown 1 NW_019212883.1 highly similar to uniprot|P02829 Saccharomyces cerevisiae YPL240C (ohnolog of YMR186W) HSP82 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; Hsp90 family chaperone HSP82 648035 34685976 LALA0_S05e07162g Lachancea lanzarotensis Hsp90 family chaperone HSP82 XP_022628732.1 645921 D 1245769 CDS LALA0_S05e07184g 34685977 join(648274..648340,648409..649199) Unknown 1 NW_019212883.1 weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2; uncharacterized protein 649199 34685977 LALA0_S05e07184g Lachancea lanzarotensis uncharacterized protein XP_022628733.1 648274 D 1245769 CDS LALA0_S05e07206g 34685978 649504..654009 Unknown 1 NW_019212883.1 similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; uncharacterized protein 654009 34685978 LALA0_S05e07206g Lachancea lanzarotensis uncharacterized protein XP_022628734.1 649504 D 1245769 CDS LALA0_S05e07228g 34685979 complement(654279..656066) Unknown 1 NW_019212883.1 similar to uniprot|C5E269 Lachancea thermotolerans KLTH0H02574g hypothetical protein; uncharacterized protein 656066 34685979 LALA0_S05e07228g Lachancea lanzarotensis uncharacterized protein XP_022628735.1 654279 R 1245769 CDS LALA0_S05e07250g 34685980 complement(656386..658179) Unknown 1 NW_019212883.1 similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; signal recognition particle subunit SRP68 658179 34685980 LALA0_S05e07250g Lachancea lanzarotensis signal recognition particle subunit SRP68 XP_022628736.1 656386 R 1245769 CDS LALA0_S05e07272g 34685981 658486..659496 Unknown 1 NW_019212883.1 similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1; UDP-galactose transporter HUT1 659496 34685981 LALA0_S05e07272g Lachancea lanzarotensis UDP-galactose transporter HUT1 XP_022628737.1 658486 D 1245769 CDS LALA0_S05e07294g 34685982 join(660187..660322,660400..661046) Unknown 1 NW_019212883.1 similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p; uncharacterized protein 661046 34685982 LALA0_S05e07294g Lachancea lanzarotensis uncharacterized protein XP_022628738.1 660187 D 1245769 CDS LALA0_S05e07316g 34685983 complement(661127..661816) Unknown 1 NW_019212883.1 similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS17m 661816 34685983 LALA0_S05e07316g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS17m XP_022628739.1 661127 R 1245769 CDS LALA0_S05e07338g 34685984 662972..664309 Unknown 1 NW_019212883.1 similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest; uncharacterized protein 664309 34685984 LALA0_S05e07338g Lachancea lanzarotensis uncharacterized protein XP_022628740.1 662972 D 1245769 CDS LALA0_S05e07360g 34685985 664931..667975 Unknown 1 NW_019212883.1 highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm; glycine decarboxylase subunit P 667975 34685985 LALA0_S05e07360g Lachancea lanzarotensis glycine decarboxylase subunit P XP_022628741.1 664931 D 1245769 CDS LALA0_S05e07382g 34685986 672596..674374 Unknown 1 NW_019212883.1 similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide; uncharacterized protein 674374 34685986 LALA0_S05e07382g Lachancea lanzarotensis uncharacterized protein XP_022628742.1 672596 D 1245769 CDS LALA0_S05e07404g 34685987 complement(674517..678731) Unknown 1 NW_019212883.1 similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; ATP-dependent DNA helicase SGS1 678731 34685987 LALA0_S05e07404g Lachancea lanzarotensis ATP-dependent DNA helicase SGS1 XP_022628743.1 674517 R 1245769 CDS LALA0_S05e07426g 34685988 679121..681289 Unknown 1 NW_019212883.1 weakly similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p; galactose-responsive transcription factor GAL4 681289 34685988 LALA0_S05e07426g Lachancea lanzarotensis galactose-responsive transcription factor GAL4 XP_022628744.1 679121 D 1245769 CDS LALA0_S05e07448g 34685989 681605..682720 Unknown 1 NW_019212883.1 weakly similar to uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; uncharacterized protein 682720 34685989 LALA0_S05e07448g Lachancea lanzarotensis uncharacterized protein XP_022628745.1 681605 D 1245769 CDS LALA0_S05e07470g 34685990 683747..686095 Unknown 1 NW_019212883.1 similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C (ohnolog of YMR192W) GYP5 GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; uncharacterized protein 686095 34685990 LALA0_S05e07470g Lachancea lanzarotensis uncharacterized protein XP_022628746.1 683747 D 1245769 CDS LALA0_S05e07492g 34685991 686301..687071 Unknown 1 NW_019212883.1 highly similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL28m 687071 34685991 LALA0_S05e07492g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL28m XP_022628747.1 686301 D 1245769 CDS LALA0_S05e07514g 34685992 join(687897..687912,688417..688703) Unknown 1 NW_019212883.1 highly similar to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A (ohnolog of YMR194W) RPL36B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA; 60S ribosomal protein eL36 688703 34685992 LALA0_S05e07514g Lachancea lanzarotensis 60S ribosomal protein eL36 XP_022628748.1 687897 D 1245769 CDS LALA0_S05e07536g 34685993 689010..689609 Unknown 1 NW_019212883.1 similar to Lachancea thermotolerans KLTH0H02508g hypothetical protein; uncharacterized protein 689609 34685993 LALA0_S05e07536g Lachancea lanzarotensis uncharacterized protein XP_022628749.1 689010 D 1245769 CDS LALA0_S05e07558g 34685994 complement(join(690314..690504,690577..690616)) Unknown 1 NW_019212883.1 similar to uniprot|Q3E7A9 Saccharomyces cerevisiae YMR194C-B CMC4 Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs; uncharacterized protein 690616 34685994 LALA0_S05e07558g Lachancea lanzarotensis uncharacterized protein XP_022628750.1 690314 R 1245769 CDS LALA0_S05e07580g 34685995 complement(691002..691394) Unknown 1 NW_019212883.1 some similarities with uniprot|P01098 Saccharomyces cerevisiae YDL130W-A (ohnolog of YDL181W) STF1 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein; uncharacterized protein 691394 34685995 LALA0_S05e07580g Lachancea lanzarotensis uncharacterized protein XP_022628751.1 691002 R 1245769 CDS LALA0_S05e07602g 34685996 692241..693170 Unknown 1 NW_019212883.1 similar to uniprot|C5E258 Lachancea thermotolerans KLTH0H02332g hypothetical protein; uncharacterized protein 693170 34685996 LALA0_S05e07602g Lachancea lanzarotensis uncharacterized protein XP_022628752.1 692241 D 1245769 CDS LALA0_S05e07624g 34685997 complement(693265..694599) Unknown 1 NW_019212883.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W (ohnolog of YDL182W) LYS21 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p; uncharacterized protein 694599 34685997 LALA0_S05e07624g Lachancea lanzarotensis uncharacterized protein XP_022628753.1 693265 R 1245769 CDS LALA0_S05e07646g 34685998 complement(695235..697688) Unknown 1 NW_019212883.1 similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; cullin CDC53 697688 34685998 LALA0_S05e07646g Lachancea lanzarotensis cullin CDC53 XP_022628754.1 695235 R 1245769 CDS LALA0_S05e07668g 34685999 complement(697981..699417) Unknown 1 NW_019212883.1 similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W SRF1 Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients; uncharacterized protein 699417 34685999 LALA0_S05e07668g Lachancea lanzarotensis uncharacterized protein XP_022628755.1 697981 R 1245769 CDS LALA0_S05e07690g 34686000 699831..700751 Unknown 1 NW_019212883.1 similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene; uncharacterized protein 700751 34686000 LALA0_S05e07690g Lachancea lanzarotensis uncharacterized protein XP_022628756.1 699831 D 1245769 CDS LALA0_S05e07734g 34686001 complement(702411..704267) Unknown 1 NW_019212883.1 some similarities with uniprot|Q6FQS3 Saccharomyces cerevisiae YDL185W VMA1 Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; H(+)-transporting V1 sector ATPase subunit A 704267 34686001 LALA0_S05e07734g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit A XP_022628757.1 702411 R 1245769 CDS LALA0_S05e07756g 34686002 complement(705665..706411) Unknown 1 NW_019212883.1 weakly similar to uniprot|P48568 Saccharomyces cerevisiae YDL186W Putative protein of unknown function; YDL186W is not an essential gene; uncharacterized protein 706411 34686002 LALA0_S05e07756g Lachancea lanzarotensis uncharacterized protein XP_022628758.1 705665 R 1245769 CDS LALA0_S05e07778g 34686003 707774..708862 Unknown 1 NW_019212883.1 highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C (ohnolog of YDL188C) PPH21 Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; phosphoprotein phosphatase 2A catalytic subunit PPH22 708862 34686003 LALA0_S05e07778g Lachancea lanzarotensis phosphoprotein phosphatase 2A catalytic subunit PPH22 XP_022628759.1 707774 D 1245769 CDS LALA0_S05e07800g 34686004 complement(709270..709845) Unknown 1 NW_019212883.1 similar to uniprot|C5E256 Lachancea thermotolerans KLTH0H02288g hypothetical protein; uncharacterized protein 709845 34686004 LALA0_S05e07800g Lachancea lanzarotensis uncharacterized protein XP_022628760.1 709270 R 1245769 CDS LALA0_S05e07822g 34686005 710315..710917 Unknown 1 NW_019212883.1 highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p; uncharacterized protein 710917 34686005 LALA0_S05e07822g Lachancea lanzarotensis uncharacterized protein XP_022628761.1 710315 D 1245769 CDS LALA0_S05e07844g 34686006 complement(711237..712133) Unknown 1 NW_019212883.1 similar to uniprot|C5E219 Lachancea thermotolerans KLTH0H01474g hypothetical protein; uncharacterized protein 712133 34686006 LALA0_S05e07844g Lachancea lanzarotensis uncharacterized protein XP_022628762.1 711237 R 1245769 CDS LALA0_S05e07866g 34686007 712552..715422 Unknown 1 NW_019212883.1 highly similar to uniprot|P54860 Saccharomyces cerevisiae YDL190C UFD2 Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3; ubiquitin-ubiquitin ligase UFD2 715422 34686007 LALA0_S05e07866g Lachancea lanzarotensis ubiquitin-ubiquitin ligase UFD2 XP_022628763.1 712552 D 1245769 CDS LALA0_S05e07888g 34686008 complement(join(715665..716024,716379..716381)) Unknown 1 NW_019212883.1 highly similar to uniprot|P0CX85 Saccharomyces cerevisiae YDL136W (ohnolog of YDL191W) RPL35B Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein; 60S ribosomal protein uL29 716381 34686008 LALA0_S05e07888g Lachancea lanzarotensis 60S ribosomal protein uL29 XP_022628764.1 715665 R 1245769 CDS LALA0_S05e07910g 34686009 complement(717360..717905) Unknown 1 NW_019212883.1 highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W (ohnolog of YDL137W) ARF1 ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p; uncharacterized protein 717905 34686009 LALA0_S05e07910g Lachancea lanzarotensis uncharacterized protein XP_022628765.1 717360 R 1245769 CDS LALA0_S05e07932g 34686010 complement(718960..720006) Unknown 1 NW_019212883.1 similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1 Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY; ditrans,polycis-polyprenyl diphosphate synthase 720006 34686010 LALA0_S05e07932g Lachancea lanzarotensis ditrans,polycis-polyprenyl diphosphate synthase XP_022628766.1 718960 R 1245769 CDS LALA0_S05e07954g 34686011 complement(721382..723604) Unknown 1 NW_019212883.1 similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 723604 34686011 LALA0_S05e07954g Lachancea lanzarotensis uncharacterized protein XP_022628767.1 721382 R 1245769 CDS LALA0_S05e07976g 34686012 complement(724531..728403) Unknown 1 NW_019212883.1 similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance; uncharacterized protein 728403 34686012 LALA0_S05e07976g Lachancea lanzarotensis uncharacterized protein XP_022628768.1 724531 R 1245769 CDS LALA0_S05e07998g 34686013 730758..731009 Unknown 1 NW_019212883.1 some similarities with uniprot|Q05809 Saccharomyces cerevisiae YLR218C COA4 Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; uncharacterized protein 731009 34686013 LALA0_S05e07998g Lachancea lanzarotensis uncharacterized protein XP_022628769.1 730758 D 1245769 CDS LALA0_S05e08020g 34686014 731156..731785 Unknown 1 NW_019212883.1 similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; uncharacterized protein 731785 34686014 LALA0_S05e08020g Lachancea lanzarotensis uncharacterized protein XP_022628770.1 731156 D 1245769 CDS LALA0_S05e08042g 34686015 731959..733071 Unknown 1 NW_019212883.1 highly similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; peptidylprolyl isomerase CPR6 733071 34686015 LALA0_S05e08042g Lachancea lanzarotensis peptidylprolyl isomerase CPR6 XP_022628771.1 731959 D 1245769 CDS LALA0_S05e08064g 34686016 734021..739261 Unknown 1 NW_019212883.1 weakly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C RPO31 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; DNA-directed RNA polymerase II subunit RPB1 739261 34686016 LALA0_S05e08064g Lachancea lanzarotensis DNA-directed RNA polymerase II subunit RPB1 XP_022628772.1 734021 D 1245769 CDS LALA0_S05e08086g 34686017 complement(739458..741509) Unknown 1 NW_019212883.1 similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; biotin--[acetyl-CoA-carboxylase] ligase BPL1 741509 34686017 LALA0_S05e08086g Lachancea lanzarotensis biotin--[acetyl-CoA-carboxylase] ligase BPL1 XP_022628773.1 739458 R 1245769 CDS LALA0_S05e08108g 34686018 741875..742687 Unknown 1 NW_019212883.1 similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis; cardiolipin synthase 742687 34686018 LALA0_S05e08108g Lachancea lanzarotensis cardiolipin synthase XP_022628774.1 741875 D 1245769 CDS LALA0_S05e08130g 34686019 complement(742870..744456) Unknown 1 NW_019212883.1 highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT4 744456 34686019 LALA0_S05e08130g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT4 XP_022628775.1 742870 R 1245769 CDS LALA0_S05e08152g 34686020 744904..746016 Unknown 1 NW_019212883.1 similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein; cell proliferation protein CDC123 746016 34686020 LALA0_S05e08152g Lachancea lanzarotensis cell proliferation protein CDC123 XP_022628776.1 744904 D 1245769 CDS LALA0_S05e08174g 34686021 complement(746079..748154) Unknown 1 NW_019212883.1 similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; ferric/cupric-chelate reductase 748154 34686021 LALA0_S05e08174g Lachancea lanzarotensis ferric/cupric-chelate reductase XP_022628777.1 746079 R 1245769 CDS LALA0_S05e08196g 34686022 749686..750771 Unknown 1 NW_019212883.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.; uncharacterized protein 750771 34686022 LALA0_S05e08196g Lachancea lanzarotensis uncharacterized protein XP_022628778.1 749686 D 1245769 CDS LALA0_S05e08218g 34686023 750994..752385 Unknown 1 NW_019212883.1 similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C CRR1 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation; uncharacterized protein 752385 34686023 LALA0_S05e08218g Lachancea lanzarotensis uncharacterized protein XP_022628779.1 750994 D 1245769 CDS LALA0_S05e08240g 34686024 752917..756552 Unknown 1 NW_019212883.1 highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway; coatomer subunit alpha 756552 34686024 LALA0_S05e08240g Lachancea lanzarotensis coatomer subunit alpha XP_022628780.1 752917 D 1245769 CDS LALA0_S05e08262g 34686025 756915..758327 Unknown 1 NW_019212883.1 similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; gamma-tubulin 758327 34686025 LALA0_S05e08262g Lachancea lanzarotensis gamma-tubulin XP_022628781.1 756915 D 1245769 CDS LALA0_S05e08284g 34686026 complement(758400..759887) Unknown 1 NW_019212883.1 similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W LDB17 Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck; uncharacterized protein 759887 34686026 LALA0_S05e08284g Lachancea lanzarotensis uncharacterized protein XP_022628782.1 758400 R 1245769 CDS LALA0_S05e08306g 34686027 join(760104..760121,760202..760771) Unknown 1 NW_019212883.1 weakly similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron; uncharacterized protein 760771 34686027 LALA0_S05e08306g Lachancea lanzarotensis uncharacterized protein XP_022628783.1 760104 D 1245769 CDS LALA0_S05e08328g 34686028 complement(760872..762197) Unknown 1 NW_019212883.1 highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; proteasome regulatory particle lid subunit RPN5 762197 34686028 LALA0_S05e08328g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN5 XP_022628784.1 760872 R 1245769 CDS LALA0_S05e08350g 34686029 763328..765778 Unknown 1 NW_019212883.1 similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein NOP14 765778 34686029 LALA0_S05e08350g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein NOP14 XP_022628785.1 763328 D 1245769 CDS LALA0_S05e08372g 34686030 complement(765852..768632) Unknown 1 NW_019212883.1 similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS; autophagy protein ATG9 768632 34686030 LALA0_S05e08372g Lachancea lanzarotensis autophagy protein ATG9 XP_022628786.1 765852 R 1245769 CDS LALA0_S05e08394g 34686031 complement(769630..770937) Unknown 1 NW_019212883.1 similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53; DNA-directed RNA polymerase III subunit C53 770937 34686031 LALA0_S05e08394g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit C53 XP_022628787.1 769630 R 1245769 CDS LALA0_S05e08416g 34686032 771363..773156 Unknown 1 NW_019212883.1 similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; rRNA-processing protein SAS10 773156 34686032 LALA0_S05e08416g Lachancea lanzarotensis rRNA-processing protein SAS10 XP_022628788.1 771363 D 1245769 CDS LALA0_S05e08438g 34686033 complement(773345..774604) Unknown 1 NW_019212883.1 similar to uniprot|P24870 Saccharomyces cerevisiae YDL155W (ohnolog of YLR210W) CLB3 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; uncharacterized protein 774604 34686033 LALA0_S05e08438g Lachancea lanzarotensis uncharacterized protein XP_022628789.1 773345 R 1245769 CDS LALA0_S05e08460g 34686034 776929..779166 Unknown 1 NW_019212883.1 weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 779166 34686034 LALA0_S05e08460g Lachancea lanzarotensis uncharacterized protein XP_022628790.1 776929 D 1245769 CDS LALA0_S05e08482g 34686035 780024..780764 Unknown 1 NW_019212883.1 similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 780764 34686035 LALA0_S05e08482g Lachancea lanzarotensis uncharacterized protein XP_022628791.1 780024 D 1245769 CDS LALA0_S05e08504g 34686036 complement(781075..782604) Unknown 1 NW_019212883.1 similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the YDL156W promoter region; uncharacterized protein 782604 34686036 LALA0_S05e08504g Lachancea lanzarotensis uncharacterized protein XP_022628792.1 781075 R 1245769 CDS LALA0_S05e08526g 34686037 782757..783074 Unknown 1 NW_019212883.1 similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 783074 34686037 LALA0_S05e08526g Lachancea lanzarotensis uncharacterized protein XP_022628793.1 782757 D 1245769 CDS LALA0_S05e08548g 34686038 complement(783233..784567) Unknown 1 NW_019212883.1 similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway; mitogen-activated protein kinase kinase STE7 784567 34686038 LALA0_S05e08548g Lachancea lanzarotensis mitogen-activated protein kinase kinase STE7 XP_022628794.1 783233 R 1245769 CDS LALA0_S05e08570g 34686039 785193..786800 Unknown 1 NW_019212883.1 highly similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; DExD/H-box ATP-dependent RNA helicase DHH1 786800 34686039 LALA0_S05e08570g Lachancea lanzarotensis DExD/H-box ATP-dependent RNA helicase DHH1 XP_022628795.1 785193 D 1245769 CDS LALA0_S05e08592g 34686040 787521..788438 Unknown 1 NW_019212883.1 similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; purine-nucleoside phosphorylase 788438 34686040 LALA0_S05e08592g Lachancea lanzarotensis purine-nucleoside phosphorylase XP_022628796.1 787521 D 1245769 CDS LALA0_S05e08614g 34686041 complement(788578..789462) Unknown 1 NW_019212883.1 highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex; required for vesicle formation in ER to Golgi transport and nuclear pore complex organization; the Nup84 subcomplex has a role in transcription elongation; GTPase-activating protein SEC13 789462 34686041 LALA0_S05e08614g Lachancea lanzarotensis GTPase-activating protein SEC13 XP_022628797.1 788578 R 1245769 CDS LALA0_S05e08636g 34686042 complement(790518..792761) Unknown 1 NW_019212883.1 similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; ubiquitin ligase complex subunit HRD3 792761 34686042 LALA0_S05e08636g Lachancea lanzarotensis ubiquitin ligase complex subunit HRD3 XP_022628798.1 790518 R 1245769 CDS LALA0_S05e08658g 34686043 794051..795229 Unknown 1 NW_019212883.1 similar to uniprot|C5E214 Lachancea thermotolerans KLTH0H01364g hypothetical protein; uncharacterized protein 795229 34686043 LALA0_S05e08658g Lachancea lanzarotensis uncharacterized protein XP_022628799.1 794051 D 1245769 CDS LALA0_S05e08680g 34686044 795325..795585 Unknown 1 NW_019212883.1 similar to uniprot|Q3E829 Saccharomyces cerevisiae YDL160C-A Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability; uncharacterized protein 795585 34686044 LALA0_S05e08680g Lachancea lanzarotensis uncharacterized protein XP_022628800.1 795325 D 1245769 CDS LALA0_S05e08702g 34686045 complement(796354..797820) Unknown 1 NW_019212883.1 similar to uniprot|Q12518 Saccharomyces cerevisiae YDL161W (ohnolog of YLR206W) ENT1 Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; epsin 797820 34686045 LALA0_S05e08702g Lachancea lanzarotensis epsin XP_022628801.1 796354 R 1245769 CDS LALA0_S05e08724g 34686046 798537..800657 Unknown 1 NW_019212883.1 similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination; DNA ligase (ATP) CDC9 800657 34686046 LALA0_S05e08724g Lachancea lanzarotensis DNA ligase (ATP) CDC9 XP_022628802.1 798537 D 1245769 CDS LALA0_S05e08746g 34686047 801086..802012 Unknown 1 NW_019212883.1 similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants; uncharacterized protein 802012 34686047 LALA0_S05e08746g Lachancea lanzarotensis uncharacterized protein XP_022628803.1 801086 D 1245769 CDS LALA0_S05e08768g 34686048 complement(802239..802532) Unknown 1 NW_019212883.1 similar to uniprot|C5E214 Lachancea thermotolerans KLTH0H01364g hypothetical protein; uncharacterized protein 802532 34686048 LALA0_S05e08768g Lachancea lanzarotensis uncharacterized protein XP_022628804.1 802239 R 1245769 CDS LALA0_S05e08790g 34686049 803835..805103 Unknown 1 NW_019212883.1 highly similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; uncharacterized protein 805103 34686049 LALA0_S05e08790g Lachancea lanzarotensis uncharacterized protein XP_022628805.1 803835 D 1245769 CDS LALA0_S05e08812g 34686050 complement(805238..805810) Unknown 1 NW_019212883.1 highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; CCR4-NOT core subunit CDC36 805810 34686050 LALA0_S05e08812g Lachancea lanzarotensis CCR4-NOT core subunit CDC36 XP_022628806.1 805238 R 1245769 CDS LALA0_S05e08834g 34686051 806047..806688 Unknown 1 NW_019212883.1 similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; nucleoside-triphosphatase 806688 34686051 LALA0_S05e08834g Lachancea lanzarotensis nucleoside-triphosphatase XP_022628807.1 806047 D 1245769 CDS LALA0_S05e08856g 34686052 807083..808690 Unknown 1 NW_019212883.1 similar to uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1 Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis; uncharacterized protein 808690 34686052 LALA0_S05e08856g Lachancea lanzarotensis uncharacterized protein XP_022628808.1 807083 D 1245769 CDS LALA0_S05e08878g 34686053 complement(808915..810060) Unknown 1 NW_019212883.1 highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase 810060 34686053 LALA0_S05e08878g Lachancea lanzarotensis bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase XP_022628809.1 808915 R 1245769 CDS LALA0_S05e08900g 34686054 810778..811560 Unknown 1 NW_019212883.1 similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C COQ9 Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone biosynthesis protein COQ9 811560 34686054 LALA0_S05e08900g Lachancea lanzarotensis ubiquinone biosynthesis protein COQ9 XP_022628810.1 810778 D 1245769 CDS LALA0_S05e08922g 34686055 complement(811683..812033) Unknown 1 NW_019212883.1 similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin; tubulin-binding prefolding complex subunit YKE2 812033 34686055 LALA0_S05e08922g Lachancea lanzarotensis tubulin-binding prefolding complex subunit YKE2 XP_022628811.1 811683 R 1245769 CDS LALA0_S05e08944g 34686056 join(812219..812224,812288..813091) Unknown 1 NW_019212883.1 similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C PBA1 Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly; uncharacterized protein 813091 34686056 LALA0_S05e08944g Lachancea lanzarotensis uncharacterized protein XP_022628812.1 812219 D 1245769 CDS LALA0_S05e08966g 34686057 complement(813239..814762) Unknown 1 NW_019212883.1 highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W NOP56 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects; snoRNP complex protein NOP56 814762 34686057 LALA0_S05e08966g Lachancea lanzarotensis snoRNP complex protein NOP56 XP_022628813.1 813239 R 1245769 CDS LALA0_S05e08988g 34686058 815240..815731 Unknown 1 NW_019212883.1 weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 Protein of unknown function, transcript accumulates in response to any combination of stress conditions; uncharacterized protein 815731 34686058 LALA0_S05e08988g Lachancea lanzarotensis uncharacterized protein XP_022628814.1 815240 D 1245769 CDS LALA0_S05e09010g 34686059 complement(815899..817617) Unknown 1 NW_019212883.1 similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; rRNA-processing protein PWP1 817617 34686059 LALA0_S05e09010g Lachancea lanzarotensis rRNA-processing protein PWP1 XP_022628815.1 815899 R 1245769 CDS LALA0_S05e09032g 34686060 818819..820168 Unknown 1 NW_019212883.1 highly similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; glycylpeptide N-tetradecanoyltransferase NMT1 820168 34686060 LALA0_S05e09032g Lachancea lanzarotensis glycylpeptide N-tetradecanoyltransferase NMT1 XP_022628816.1 818819 D 1245769 CDS LALA0_S05e09054g 34686061 820608..821150 Unknown 1 NW_019212883.1 weakly similar to uniprot|Q05777 Saccharomyces cerevisiae YLR194C Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; uncharacterized protein 821150 34686061 LALA0_S05e09054g Lachancea lanzarotensis uncharacterized protein XP_022628817.1 820608 D 1245769 CDS LALA0_S05e09076g 34686062 821651..822175 Unknown 1 NW_019212883.1 similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C UPS1 Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI; uncharacterized protein 822175 34686062 LALA0_S05e09076g Lachancea lanzarotensis uncharacterized protein XP_022628818.1 821651 D 1245769 CDS LALA0_S05e09098g 34686063 complement(822332..824305) Unknown 1 NW_019212883.1 weakly similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; uncharacterized protein 824305 34686063 LALA0_S05e09098g Lachancea lanzarotensis uncharacterized protein XP_022628819.1 822332 R 1245769 CDS LALA0_S05e09120g 34686064 complement(824835..825482) Unknown 1 NW_019212883.1 similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; 2',3'-cyclic-nucleotide 3'-phosphodiesterase 825482 34686064 LALA0_S05e09120g Lachancea lanzarotensis 2',3'-cyclic-nucleotide 3'-phosphodiesterase XP_022628820.1 824835 R 1245769 CDS LALA0_S05e09142g 34686065 826255..827961 Unknown 1 NW_019212883.1 similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; transcription factor TFIIIB subunit BRF1 827961 34686065 LALA0_S05e09142g Lachancea lanzarotensis transcription factor TFIIIB subunit BRF1 XP_022628821.1 826255 D 1245769 CDS LALA0_S05e09164g 34686066 828221..830386 Unknown 1 NW_019212883.1 highly similar to uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis; uncharacterized protein 830386 34686066 LALA0_S05e09164g Lachancea lanzarotensis uncharacterized protein XP_022628822.1 828221 D 1245769 CDS LALA0_S05e09186g 34686067 831474..832727 Unknown 1 NW_019212883.1 highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; succinate--CoA ligase (GDP-forming) subunit beta 832727 34686067 LALA0_S05e09186g Lachancea lanzarotensis succinate--CoA ligase (GDP-forming) subunit beta XP_022628823.1 831474 D 1245769 CDS LALA0_S05e09208g 34686068 complement(join(833040..833399,833904..833978)) Unknown 1 NW_019212883.1 similar to uniprot|P38857 Saccharomyces cerevisiae YHR162W (ohnolog of YGR243W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; uncharacterized protein 833978 34686068 LALA0_S05e09208g Lachancea lanzarotensis uncharacterized protein XP_022628824.1 833040 R 1245769 CDS LALA0_S05e09252g 34686070 complement(836164..836931) Unknown 1 NW_019212883.1 similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W (ohnolog of YGR248W) SOL3 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; 6-phosphogluconolactonase SOL3 836931 34686070 LALA0_S05e09252g Lachancea lanzarotensis 6-phosphogluconolactonase SOL3 XP_022628825.1 836164 R 1245769 CDS LALA0_S05e09274g 34686071 840931..842136 Unknown 1 NW_019212883.1 weakly similar to uniprot|P53050 Saccharomyces cerevisiae YGR249W MGA1 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants; uncharacterized protein 842136 34686071 LALA0_S05e09274g Lachancea lanzarotensis uncharacterized protein XP_022628826.1 840931 D 1245769 CDS LALA0_S05e09296g 34686072 complement(842609..845044) Unknown 1 NW_019212883.1 similar to uniprot|P53316 Saccharomyces cerevisiae YGR250C Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid; uncharacterized protein 845044 34686072 LALA0_S05e09296g Lachancea lanzarotensis uncharacterized protein XP_022628827.1 842609 R 1245769 CDS LALA0_S05e09318g 34686073 complement(845659..850431) Unknown 1 NW_019212883.1 similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 850431 34686073 LALA0_S05e09318g Lachancea lanzarotensis bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 XP_022628828.1 845659 R 1245769 CDS LALA0_S05e09340g 34686074 complement(850873..851652) Unknown 1 NW_019212883.1 hypothetical protein; uncharacterized protein 851652 34686074 LALA0_S05e09340g Lachancea lanzarotensis uncharacterized protein XP_022628829.1 850873 R 1245769 CDS LALA0_S05e09362g 34686075 complement(851890..859230) Unknown 1 NW_019212883.1 highly similar to uniprot|W9XS86 Capronia coronata A1O1_07019 hypothetical protein; U4/U6-U5 snRNP complex subunit PRP8 859230 34686075 LALA0_S05e09362g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP8 XP_022628830.1 851890 R 1245769 CDS LALA0_S05e09384g 34686076 complement(859435..861303) Unknown 1 NW_019212883.1 similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; anaphase promoting complex subunit CDC23 861303 34686076 LALA0_S05e09384g Lachancea lanzarotensis anaphase promoting complex subunit CDC23 XP_022628831.1 859435 R 1245769 CDS LALA0_S05e09406g 34686077 861504..862286 Unknown 1 NW_019212883.1 weakly similar to uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance; uncharacterized protein 862286 34686077 LALA0_S05e09406g Lachancea lanzarotensis uncharacterized protein XP_022628832.1 861504 D 1245769 CDS LALA0_S05e09428g 34686078 862516..864138 Unknown 1 NW_019212883.1 similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; uncharacterized protein 864138 34686078 LALA0_S05e09428g Lachancea lanzarotensis uncharacterized protein XP_022628833.1 862516 D 1245769 CDS LALA0_S05e09450g 34686079 864296..865603 Unknown 1 NW_019212883.1 highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; ATP-dependent RNA helicase DBP8 865603 34686079 LALA0_S05e09450g Lachancea lanzarotensis ATP-dependent RNA helicase DBP8 XP_022628834.1 864296 D 1245769 CDS LALA0_S05e09472g 34686080 865868..866461 Unknown 1 NW_019212883.1 similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; uncharacterized protein 866461 34686080 LALA0_S05e09472g Lachancea lanzarotensis uncharacterized protein XP_022628835.1 865868 D 1245769 CDS LALA0_S05e09494g 34686081 866764..868293 Unknown 1 NW_019212883.1 highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; ribosome-binding protein NMD3 868293 34686081 LALA0_S05e09494g Lachancea lanzarotensis ribosome-binding protein NMD3 XP_022628836.1 866764 D 1245769 CDS LALA0_S05e09516g 34686082 868532..870421 Unknown 1 NW_019212883.1 similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation; uncharacterized protein 870421 34686082 LALA0_S05e09516g Lachancea lanzarotensis uncharacterized protein XP_022628837.1 868532 D 1245769 CDS LALA0_S05e09538g 34686083 870609..871901 Unknown 1 NW_019212883.1 highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; histone acetyltransferase GCN5 871901 34686083 LALA0_S05e09538g Lachancea lanzarotensis histone acetyltransferase GCN5 XP_022628838.1 870609 D 1245769 CDS LALA0_S05e09560g 34686084 complement(872033..872818) Unknown 1 NW_019212883.1 highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; proteasome core particle subunit alpha 5 872818 34686084 LALA0_S05e09560g Lachancea lanzarotensis proteasome core particle subunit alpha 5 XP_022628839.1 872033 R 1245769 CDS LALA0_S05e09582g 34686085 complement(873262..876090) Unknown 1 NW_019212883.1 similar to uniprot|P32259 Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription; uncharacterized protein 876090 34686085 LALA0_S05e09582g Lachancea lanzarotensis uncharacterized protein XP_022628840.1 873262 R 1245769 CDS LALA0_S05e09604g 34686086 complement(876534..877868) Unknown 1 NW_019212883.1 similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W YTP1 Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins; uncharacterized protein 877868 34686086 LALA0_S05e09604g Lachancea lanzarotensis uncharacterized protein XP_022628841.1 876534 R 1245769 CDS LALA0_S05e09626g 34686087 complement(878146..880509) Unknown 1 NW_019212883.1 similar to uniprot|P13134 Saccharomyces cerevisiae YNL238W KEX2 Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; kexin KEX2 880509 34686087 LALA0_S05e09626g Lachancea lanzarotensis kexin KEX2 XP_022628842.1 878146 R 1245769 CDS LALA0_S05e09648g 34686088 881807..883198 Unknown 1 NW_019212883.1 similar to uniprot|P23503 Saccharomyces cerevisiae YNL240C NAR1 Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf; iron-sulfur cluster assembly protein NAR1 883198 34686088 LALA0_S05e09648g Lachancea lanzarotensis iron-sulfur cluster assembly protein NAR1 XP_022628843.1 881807 D 1245769 CDS LALA0_S05e09670g 34686089 885124..886653 Unknown 1 NW_019212883.1 highly similar to uniprot|P11412 Saccharomyces cerevisiae YNL241C ZWF1 Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; glucose-6-phosphate dehydrogenase 886653 34686089 LALA0_S05e09670g Lachancea lanzarotensis glucose-6-phosphate dehydrogenase XP_022628844.1 885124 D 1245769 CDS LALA0_S05e09692g 34686090 complement(886994..890110) Unknown 1 NW_019212883.1 similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis; GTPase-activating protein LRG1 890110 34686090 LALA0_S05e09692g Lachancea lanzarotensis GTPase-activating protein LRG1 XP_022628845.1 886994 R 1245769 CDS LALA0_S05e09714g 34686091 complement(890477..895174) Unknown 1 NW_019212883.1 similar to uniprot|P53855 Saccharomyces cerevisiae YNL242W ATG2 Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; uncharacterized protein 895174 34686091 LALA0_S05e09714g Lachancea lanzarotensis uncharacterized protein XP_022628846.1 890477 R 1245769 CDS LALA0_S05e09736g 34686092 complement(895817..897349) Unknown 1 NW_019212883.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 897349 34686092 LALA0_S05e09736g Lachancea lanzarotensis uncharacterized protein XP_022628847.1 895817 R 1245769 CDS LALA0_S05e09758g 34686093 898790..900232 Unknown 1 NW_019212883.1 weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1; uncharacterized protein 900232 34686093 LALA0_S05e09758g Lachancea lanzarotensis uncharacterized protein XP_022628848.1 898790 D 1245769 CDS LALA0_S05e09780g 34686094 complement(900622..902124) Unknown 1 NW_019212883.1 weakly similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; uncharacterized protein 902124 34686094 LALA0_S05e09780g Lachancea lanzarotensis uncharacterized protein XP_022628849.1 900622 R 1245769 CDS LALA0_S05e09802g 34686095 902413..903435 Unknown 1 NW_019212883.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.; uncharacterized protein 903435 34686095 LALA0_S05e09802g Lachancea lanzarotensis uncharacterized protein XP_022628850.1 902413 D 1245769 CDS LALA0_S05e09824g 34686096 complement(903582..904997) Unknown 1 NW_019212883.1 similar to uniprot|C5DGZ8 Lachancea thermotolerans KLTH0E00154g putative inosine/uridine hydrolase; uncharacterized protein 904997 34686096 LALA0_S05e09824g Lachancea lanzarotensis uncharacterized protein XP_022628851.1 903582 R 1245769 CDS LALA0_S05e09846g 34686097 complement(905836..907389) Unknown 1 NW_019212883.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 907389 34686097 LALA0_S05e09846g Lachancea lanzarotensis uncharacterized protein XP_022628852.1 905836 R 1245769 CDS LALA0_S05e09868g 34686098 complement(907723..909849) Unknown 1 NW_019212883.1 weakly similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p; uncharacterized protein 909849 34686098 LALA0_S05e09868g Lachancea lanzarotensis uncharacterized protein XP_022628853.1 907723 R 1245769 CDS LALA0_S05e09890g 34686099 complement(join(910297..910443,910445..910666)) Unknown 1 NW_019212883.1 some similarities with Lachancea thermotolerans KLTH0C00440g hypothetical protein; 910666 34686099 LALA0_S05e09890g Lachancea lanzarotensis 910297 R 1245769 CDS LALA0_S06e00100g 34686100 complement(1656..2390) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin; uncharacterized protein 2390 34686100 LALA0_S06e00100g Lachancea lanzarotensis uncharacterized protein XP_022628854.1 1656 R 1245769 CDS LALA0_S06e00122g 34686101 complement(5221..8259) Unknown 1 NW_019212884.1 similar to uniprot|P38360 Saccharomyces cerevisiae YBR295W PCA1 Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function; cation-transporting P-type ATPase PCA1 8259 34686101 LALA0_S06e00122g Lachancea lanzarotensis cation-transporting P-type ATPase PCA1 XP_022628855.1 5221 R 1245769 CDS LALA0_S06e00144g 34686102 complement(11019..12689) Unknown 1 NW_019212884.1 similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinitytransport of proline; also transports the toxic prolineanalog azetidine-2-carboxylate (AzC); PUT4 transcriptionis repressed in ammonia-grown cells; uncharacterized protein 12689 34686102 LALA0_S06e00144g Lachancea lanzarotensis uncharacterized protein XP_022628856.1 11019 R 1245769 CDS LALA0_S06e00166g 34686103 15875..17575 Unknown 1 NW_019212884.1 similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively; uncharacterized protein 17575 34686103 LALA0_S06e00166g Lachancea lanzarotensis uncharacterized protein XP_022628857.1 15875 D 1245769 CDS LALA0_S06e00188g 34686104 complement(20318..21508) Unknown 1 NW_019212884.1 similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; flavohemoglobin 21508 34686104 LALA0_S06e00188g Lachancea lanzarotensis flavohemoglobin XP_022628858.1 20318 R 1245769 CDS LALA0_S06e00210g 34686105 complement(22530..24191) Unknown 1 NW_019212884.1 similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase; uncharacterized protein 24191 34686105 LALA0_S06e00210g Lachancea lanzarotensis uncharacterized protein XP_022628859.1 22530 R 1245769 CDS LALA0_S06e00232g 34686106 25017..25721 Unknown 1 NW_019212884.1 highly similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p; bifunctional glutathione transferase/peroxidase 25721 34686106 LALA0_S06e00232g Lachancea lanzarotensis bifunctional glutathione transferase/peroxidase XP_022628860.1 25017 D 1245769 CDS LALA0_S06e00254g 34686107 27543..29024 Unknown 1 NW_019212884.1 highly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 29024 34686107 LALA0_S06e00254g Lachancea lanzarotensis uncharacterized protein XP_022628861.1 27543 D 1245769 CDS LALA0_S06e00276g 34686108 30642..31559 Unknown 1 NW_019212884.1 highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated; uncharacterized protein 31559 34686108 LALA0_S06e00276g Lachancea lanzarotensis uncharacterized protein XP_022628862.1 30642 D 1245769 CDS LALA0_S06e00298g 34686109 complement(join(31741..32277,32514..32555)) Unknown 1 NW_019212884.1 similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus; uncharacterized protein 32555 34686109 LALA0_S06e00298g Lachancea lanzarotensis uncharacterized protein XP_022628863.1 31741 R 1245769 CDS LALA0_S06e00320g 34686110 complement(32692..34854) Unknown 1 NW_019212884.1 similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; uncharacterized protein 34854 34686110 LALA0_S06e00320g Lachancea lanzarotensis uncharacterized protein XP_022628864.1 32692 R 1245769 CDS LALA0_S06e00342g 34686111 36064..37938 Unknown 1 NW_019212884.1 similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; phosphatidylinositol-3-phosphatase SAC1 37938 34686111 LALA0_S06e00342g Lachancea lanzarotensis phosphatidylinositol-3-phosphatase SAC1 XP_022628865.1 36064 D 1245769 CDS LALA0_S06e00364g 34686112 complement(37991..39457) Unknown 1 NW_019212884.1 highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p; bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase 39457 34686112 LALA0_S06e00364g Lachancea lanzarotensis bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase XP_022628866.1 37991 R 1245769 CDS LALA0_S06e00386g 34686113 40412..41641 Unknown 1 NW_019212884.1 highly similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; septin CDC11 41641 34686113 LALA0_S06e00386g Lachancea lanzarotensis septin CDC11 XP_022628867.1 40412 D 1245769 CDS LALA0_S06e00408g 34686114 complement(42220..43422) Unknown 1 NW_019212884.1 similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele; alpha-1,6-mannosyltransferase 43422 34686114 LALA0_S06e00408g Lachancea lanzarotensis alpha-1,6-mannosyltransferase XP_022628868.1 42220 R 1245769 CDS LALA0_S06e00430g 34686115 complement(43784..44386) Unknown 1 NW_019212884.1 similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p; Ran GTPase-binding protein MOG1 44386 34686115 LALA0_S06e00430g Lachancea lanzarotensis Ran GTPase-binding protein MOG1 XP_022628869.1 43784 R 1245769 CDS LALA0_S06e00452g 34686116 44978..47110 Unknown 1 NW_019212884.1 putative transposase of the Rover hAT-like DNA transposon 47110 34686116 LALA0_S06e00452g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022628870.1 44978 D 1245769 CDS LALA0_S06e00474g 34686117 47719..50766 Unknown 1 NW_019212884.1 highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability; E1 ubiquitin-activating protein UBA1 50766 34686117 LALA0_S06e00474g Lachancea lanzarotensis E1 ubiquitin-activating protein UBA1 XP_022628871.1 47719 D 1245769 CDS LALA0_S06e00496g 34686118 complement(50850..54734) Unknown 1 NW_019212884.1 similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; ATP-binding cassette a-factor transporter STE6 54734 34686118 LALA0_S06e00496g Lachancea lanzarotensis ATP-binding cassette a-factor transporter STE6 XP_022628872.1 50850 R 1245769 CDS LALA0_S06e00518g 34686119 55891..56553 Unknown 1 NW_019212884.1 similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase 56553 34686119 LALA0_S06e00518g Lachancea lanzarotensis bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase XP_022628873.1 55891 D 1245769 CDS LALA0_S06e00540g 34686120 56996..58231 Unknown 1 NW_019212884.1 highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 58231 34686120 LALA0_S06e00540g Lachancea lanzarotensis uncharacterized protein XP_022628874.1 56996 D 1245769 CDS LALA0_S06e00562g 34686121 60256..61980 Unknown 1 NW_019212884.1 similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease, mediateshigh-affinity and high-capacity transport of L-glutamateand L-aspartate; also a transporter for Gln, Asn, Ser,Ala, and Gly; dicarboxylic amino acid permease 61980 34686121 LALA0_S06e00562g Lachancea lanzarotensis dicarboxylic amino acid permease XP_022628875.1 60256 D 1245769 CDS LALA0_S06e00584g 34686122 62773..64044 Unknown 1 NW_019212884.1 weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 64044 34686122 LALA0_S06e00584g Lachancea lanzarotensis uncharacterized protein XP_022628876.1 62773 D 1245769 CDS LALA0_S06e00606g 34686123 64540..65622 Unknown 1 NW_019212884.1 weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 65622 34686123 LALA0_S06e00606g Lachancea lanzarotensis uncharacterized protein XP_022628877.1 64540 D 1245769 CDS LALA0_S06e00628g 34686124 67835..68920 Unknown 1 NW_019212884.1 weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 68920 34686124 LALA0_S06e00628g Lachancea lanzarotensis uncharacterized protein XP_022628878.1 67835 D 1245769 CDS LALA0_S06e00650g 34686125 69978..71063 Unknown 1 NW_019212884.1 weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 71063 34686125 LALA0_S06e00650g Lachancea lanzarotensis uncharacterized protein XP_022628879.1 69978 D 1245769 CDS LALA0_S06e00672g 34686126 72106..73224 Unknown 1 NW_019212884.1 weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 73224 34686126 LALA0_S06e00672g Lachancea lanzarotensis uncharacterized protein XP_022628880.1 72106 D 1245769 CDS LALA0_S06e00694g 34686127 complement(74069..75763) Unknown 1 NW_019212884.1 highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvatedecarboxylase isozymes, key enzyme in alcoholicfermentation, decarboxylates pyruvate to acetaldehyde;subject to glucose-, ethanol-, and autoregulation;involved in amino acid catabolism; uncharacterized protein 75763 34686127 LALA0_S06e00694g Lachancea lanzarotensis uncharacterized protein XP_022628881.1 74069 R 1245769 CDS LALA0_S06e00716g 34686128 complement(78053..79261) Unknown 1 NW_019212884.1 similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core; uncharacterized protein 79261 34686128 LALA0_S06e00716g Lachancea lanzarotensis uncharacterized protein XP_022628882.1 78053 R 1245769 CDS LALA0_S06e00738g 34686129 complement(79785..81527) Unknown 1 NW_019212884.1 similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains; xylulokinase 81527 34686129 LALA0_S06e00738g Lachancea lanzarotensis xylulokinase XP_022628883.1 79785 R 1245769 CDS LALA0_S06e00760g 34686130 complement(81902..82168) Unknown 1 NW_019212884.1 similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A SPC1 Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex; signal peptidase complex subunit SPC1 82168 34686130 LALA0_S06e00760g Lachancea lanzarotensis signal peptidase complex subunit SPC1 XP_022628884.1 81902 R 1245769 CDS LALA0_S06e00782g 34686131 complement(82403..83182) Unknown 1 NW_019212884.1 weakly similar to uniprot|P47086 Saccharomyces cerevisiae YJR011C Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; uncharacterized protein 83182 34686131 LALA0_S06e00782g Lachancea lanzarotensis uncharacterized protein XP_022628885.1 82403 R 1245769 CDS LALA0_S06e00804g 34686132 84470..85375 Unknown 1 NW_019212884.1 weakly similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p; uncharacterized protein 85375 34686132 LALA0_S06e00804g Lachancea lanzarotensis uncharacterized protein XP_022628886.1 84470 D 1245769 CDS LALA0_S06e00826g 34686133 complement(85564..85920) Unknown 1 NW_019212884.1 some similarities with uniprot|P47087 Saccharomyces cerevisiae YJR012C Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W; uncharacterized protein 85920 34686133 LALA0_S06e00826g Lachancea lanzarotensis uncharacterized protein XP_022628887.1 85564 R 1245769 CDS LALA0_S06e00848g 34686134 86134..87321 Unknown 1 NW_019212884.1 similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M; glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I 87321 34686134 LALA0_S06e00848g Lachancea lanzarotensis glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I XP_022628888.1 86134 D 1245769 CDS LALA0_S06e00870g 34686135 87487..88230 Unknown 1 NW_019212884.1 highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4); exosome non-catalytic core subunit SKI6 88230 34686135 LALA0_S06e00870g Lachancea lanzarotensis exosome non-catalytic core subunit SKI6 XP_022628889.1 87487 D 1245769 CDS LALA0_S06e00892g 34686136 complement(88346..90829) Unknown 1 NW_019212884.1 weakly similar to uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function, required for survival upon exposure to K1 killer toxin; uncharacterized protein 90829 34686136 LALA0_S06e00892g Lachancea lanzarotensis uncharacterized protein XP_022628890.1 88346 R 1245769 CDS LALA0_S06e00914g 34686137 91743..92342 Unknown 1 NW_019212884.1 highly similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W TMA22 Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; uncharacterized protein 92342 34686137 LALA0_S06e00914g Lachancea lanzarotensis uncharacterized protein XP_022628891.1 91743 D 1245769 CDS LALA0_S06e00936g 34686138 92507..94708 Unknown 1 NW_019212884.1 similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W YPP1 Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene; uncharacterized protein 94708 34686138 LALA0_S06e00936g Lachancea lanzarotensis uncharacterized protein XP_022628892.1 92507 D 1245769 CDS LALA0_S06e00958g 34686139 94959..97214 Unknown 1 NW_019212884.1 similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases; dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 97214 34686139 LALA0_S06e00958g Lachancea lanzarotensis dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 XP_022628893.1 94959 D 1245769 CDS LALA0_S06e00980g 34686140 complement(97240..99627) Unknown 1 NW_019212884.1 similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin; Elongator subunit ELP2 99627 34686140 LALA0_S06e00980g Lachancea lanzarotensis Elongator subunit ELP2 XP_022628894.1 97240 R 1245769 CDS LALA0_S06e01002g 34686141 complement(99983..101749) Unknown 1 NW_019212884.1 highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; dihydroxy-acid dehydratase ILV3 101749 34686141 LALA0_S06e01002g Lachancea lanzarotensis dihydroxy-acid dehydratase ILV3 XP_022628895.1 99983 R 1245769 CDS LALA0_S06e01024g 34686142 complement(102048..103208) Unknown 1 NW_019212884.1 similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; choline-phosphate cytidylyltransferase 103208 34686142 LALA0_S06e01024g Lachancea lanzarotensis choline-phosphate cytidylyltransferase XP_022628896.1 102048 R 1245769 CDS LALA0_S06e01046g 34686143 103924..104361 Unknown 1 NW_019212884.1 similar to uniprot|P42937 Saccharomyces cerevisiae YGR203W YCH1 Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; phosphatase YCH1 104361 34686143 LALA0_S06e01046g Lachancea lanzarotensis phosphatase YCH1 XP_022628897.1 103924 D 1245769 CDS LALA0_S06e01068g 34686144 complement(104481..104969) Unknown 1 NW_019212884.1 similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain; peptidylprolyl isomerase ESS1 104969 34686144 LALA0_S06e01068g Lachancea lanzarotensis peptidylprolyl isomerase ESS1 XP_022628898.1 104481 R 1245769 CDS LALA0_S06e01090g 34686145 106351..109188 Unknown 1 NW_019212884.1 similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine; trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 109188 34686145 LALA0_S06e01090g Lachancea lanzarotensis trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 XP_022628899.1 106351 D 1245769 CDS LALA0_S06e01112g 34686146 complement(109282..110268) Unknown 1 NW_019212884.1 similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids; palmitoyl-CoA hydrolase 110268 34686146 LALA0_S06e01112g Lachancea lanzarotensis palmitoyl-CoA hydrolase XP_022628900.1 109282 R 1245769 CDS LALA0_S06e01134g 34686147 110467..111366 Unknown 1 NW_019212884.1 similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W TDA10 ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele; uncharacterized protein 111366 34686147 LALA0_S06e01134g Lachancea lanzarotensis uncharacterized protein XP_022628901.1 110467 D 1245769 CDS LALA0_S06e01156g 34686148 complement(join(111509..112344,112419..112644)) Unknown 1 NW_019212884.1 weakly similar to uniprot|P21651 Saccharomyces cerevisiae YJR021C REC107 Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation; uncharacterized protein 112644 34686148 LALA0_S06e01156g Lachancea lanzarotensis uncharacterized protein XP_022628902.1 111509 R 1245769 CDS LALA0_S06e01178g 34686149 113020..113367 Unknown 1 NW_019212884.1 similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA; U4/U6-U5 snRNP complex subunit LSM8 113367 34686149 LALA0_S06e01178g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit LSM8 XP_022628903.1 113020 D 1245769 CDS LALA0_S06e01200g 34686150 complement(113532..114314) Unknown 1 NW_019212884.1 similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C MDE1 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; 114314 34686150 LALA0_S06e01200g Lachancea lanzarotensis 113532 R 1245769 CDS LALA0_S06e01222g 34686151 complement(114642..115172) Unknown 1 NW_019212884.1 highly similar to uniprot|P47096 Saccharomyces cerevisiae YJR025C BNA1 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; 3-hydroxyanthranilate 3,4-dioxygenase 115172 34686151 LALA0_S06e01222g Lachancea lanzarotensis 3-hydroxyanthranilate 3,4-dioxygenase XP_022628904.1 114642 R 1245769 CDS LALA0_S06e01244g 34686152 116095..116403 Unknown 1 NW_019212884.1 weakly similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W MVB12 ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin; ubiquitin-binding ESCRT-I subunit protein MVB12 116403 34686152 LALA0_S06e01244g Lachancea lanzarotensis ubiquitin-binding ESCRT-I subunit protein MVB12 XP_022628905.1 116095 D 1245769 CDS LALA0_S06e01266g 34686153 complement(116576..117352) Unknown 1 NW_019212884.1 highly similar to uniprot|P42940 Saccharomyces cerevisiae YGR207C CIR1 Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response; uncharacterized protein 117352 34686153 LALA0_S06e01266g Lachancea lanzarotensis uncharacterized protein XP_022628906.1 116576 R 1245769 CDS LALA0_S06e01288g 34686154 117776..118711 Unknown 1 NW_019212884.1 similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source; phosphoserine phosphatase 118711 34686154 LALA0_S06e01288g Lachancea lanzarotensis phosphoserine phosphatase XP_022628907.1 117776 D 1245769 CDS LALA0_S06e01310g 34686155 complement(118881..119192) Unknown 1 NW_019212884.1 highly similar to uniprot|P22803 Saccharomyces cerevisiae YGR209C (ohnolog of YLR043C) TRX2 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; thioredoxin TRX2 119192 34686155 LALA0_S06e01310g Lachancea lanzarotensis thioredoxin TRX2 XP_022628908.1 118881 R 1245769 CDS LALA0_S06e01354g 34686157 120905..123541 Unknown 1 NW_019212884.1 similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p; uncharacterized protein 123541 34686157 LALA0_S06e01354g Lachancea lanzarotensis uncharacterized protein XP_022628909.1 120905 D 1245769 CDS LALA0_S06e01376g 34686158 complement(123687..124709) Unknown 1 NW_019212884.1 similar to uniprot|C5DCD0 Lachancea thermotolerans KLTH0B02024g hypothetical protein; uncharacterized protein 124709 34686158 LALA0_S06e01376g Lachancea lanzarotensis uncharacterized protein XP_022628910.1 123687 R 1245769 CDS LALA0_S06e01398g 34686159 complement(125767..127281) Unknown 1 NW_019212884.1 highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; sulfate adenylyltransferase 127281 34686159 LALA0_S06e01398g Lachancea lanzarotensis sulfate adenylyltransferase XP_022628911.1 125767 R 1245769 CDS LALA0_S06e01420g 34686160 complement(129247..130221) Unknown 1 NW_019212884.1 similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.; uncharacterized protein 130221 34686160 LALA0_S06e01420g Lachancea lanzarotensis uncharacterized protein XP_022628912.1 129247 R 1245769 CDS LALA0_S06e01442g 34686161 complement(130564..131472) Unknown 1 NW_019212884.1 highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; translation initiation factor eIF2 subunit alpha 131472 34686161 LALA0_S06e01442g Lachancea lanzarotensis translation initiation factor eIF2 subunit alpha XP_022628913.1 130564 R 1245769 CDS LALA0_S06e01464g 34686162 complement(133117..137316) Unknown 1 NW_019212884.1 similar to uniprot|C5DCF3 Lachancea thermotolerans KLTH0B02596g hypothetical protein; uncharacterized protein 137316 34686162 LALA0_S06e01464g Lachancea lanzarotensis uncharacterized protein XP_022628914.1 133117 R 1245769 CDS LALA0_S06e01508g 34686164 138723..140099 Unknown 1 NW_019212884.1 similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress; transglycosylase 140099 34686164 LALA0_S06e01508g Lachancea lanzarotensis transglycosylase XP_022628915.1 138723 D 1245769 CDS LALA0_S06e01552g 34686166 140784..141251 Unknown 1 NW_019212884.1 similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; DNA-directed RNA polymerase III subunit RPC17 141251 34686166 LALA0_S06e01552g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit RPC17 XP_022628916.1 140784 D 1245769 CDS LALA0_S06e01574g 34686167 142010..144142 Unknown 1 NW_019212884.1 highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; uncharacterized protein 144142 34686167 LALA0_S06e01574g Lachancea lanzarotensis uncharacterized protein XP_022628917.1 142010 D 1245769 CDS LALA0_S06e01596g 34686168 144459..147425 Unknown 1 NW_019212884.1 similar to uniprot|P47074 Saccharomyces cerevisiae YJL013C (ohnolog of YGR188C) MAD3 Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; uncharacterized protein 147425 34686168 LALA0_S06e01596g Lachancea lanzarotensis uncharacterized protein XP_022628918.1 144459 D 1245769 CDS LALA0_S06e01618g 34686169 complement(147562..149160) Unknown 1 NW_019212884.1 highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT3 149160 34686169 LALA0_S06e01618g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT3 XP_022628919.1 147562 R 1245769 CDS LALA0_S06e01640g 34686170 complement(150757..152322) Unknown 1 NW_019212884.1 weakly similar to uniprot|P47071 Saccharomyces cerevisiae YJL016W Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species; uncharacterized protein 152322 34686170 LALA0_S06e01640g Lachancea lanzarotensis uncharacterized protein XP_022628920.1 150757 R 1245769 CDS LALA0_S06e01662g 34686171 complement(152862..154865) Unknown 1 NW_019212884.1 similar to uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere- led rapid prophase movement; uncharacterized protein 154865 34686171 LALA0_S06e01662g Lachancea lanzarotensis uncharacterized protein XP_022628921.1 152862 R 1245769 CDS LALA0_S06e01684g 34686172 join(156899..157492,157766..158215) Unknown 1 NW_019212884.1 similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets; mitochondrial 37S ribosomal protein mS45 158215 34686172 LALA0_S06e01684g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS45 XP_022628922.1 156899 D 1245769 CDS LALA0_S06e01706g 34686173 158752..160143 Unknown 1 NW_019212884.1 weakly similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W TRS65 Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response; uncharacterized protein 160143 34686173 LALA0_S06e01706g Lachancea lanzarotensis uncharacterized protein XP_022628923.1 158752 D 1245769 CDS LALA0_S06e01728g 34686174 160464..161108 Unknown 1 NW_019212884.1 similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; uncharacterized protein 161108 34686174 LALA0_S06e01728g Lachancea lanzarotensis uncharacterized protein XP_022628924.1 160464 D 1245769 CDS LALA0_S06e01750g 34686175 complement(161312..162343) Unknown 1 NW_019212884.1 weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Putative protein of unknown function; YGR168C is not an essential gene; uncharacterized protein 162343 34686175 LALA0_S06e01750g Lachancea lanzarotensis uncharacterized protein XP_022628925.1 161312 R 1245769 CDS LALA0_S06e01772g 34686176 163715..167023 Unknown 1 NW_019212884.1 weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; uncharacterized protein 167023 34686176 LALA0_S06e01772g Lachancea lanzarotensis uncharacterized protein XP_022628926.1 163715 D 1245769 CDS LALA0_S06e01794g 34686177 complement(167079..168335) Unknown 1 NW_019212884.1 similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability; uncharacterized protein 168335 34686177 LALA0_S06e01794g Lachancea lanzarotensis uncharacterized protein XP_022628927.1 167079 R 1245769 CDS LALA0_S06e01816g 34686178 169080..170090 Unknown 1 NW_019212884.1 weakly similar to uniprot|P47065 Saccharomyces cerevisiae YJL023C PET130 Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 170090 34686178 LALA0_S06e01816g Lachancea lanzarotensis uncharacterized protein XP_022628928.1 169080 D 1245769 CDS LALA0_S06e01838g 34686179 complement(170332..170598) Unknown 1 NW_019212884.1 similar to uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A (ohnolog of YJR005C-A) Putative protein of unknown function; uncharacterized protein 170598 34686179 LALA0_S06e01838g Lachancea lanzarotensis uncharacterized protein XP_022628929.1 170332 R 1245769 CDS LALA0_S06e01860g 34686180 171489..174767 Unknown 1 NW_019212884.1 similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine; phosphatidylserine decarboxylase 2 174767 34686180 LALA0_S06e01860g Lachancea lanzarotensis phosphatidylserine decarboxylase 2 XP_022628930.1 171489 D 1245769 CDS LALA0_S06e01882g 34686181 join(175200..175225,175310..176681) Unknown 1 NW_019212884.1 similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W POL31 DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair; DNA-directed DNA polymerase delta subunit POL31 176681 34686181 LALA0_S06e01882g Lachancea lanzarotensis DNA-directed DNA polymerase delta subunit POL31 XP_022628931.1 175200 D 1245769 CDS LALA0_S06e01904g 34686182 complement(176720..178453) Unknown 1 NW_019212884.1 similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p; methionine--tRNA ligase MSM1 178453 34686182 LALA0_S06e01904g Lachancea lanzarotensis methionine--tRNA ligase MSM1 XP_022628932.1 176720 R 1245769 CDS LALA0_S06e01926g 34686183 complement(178720..179469) Unknown 1 NW_019212884.1 similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4; transporter YIP1 179469 34686183 LALA0_S06e01926g Lachancea lanzarotensis transporter YIP1 XP_022628933.1 178720 R 1245769 CDS LALA0_S06e01948g 34686184 182353..183459 Unknown 1 NW_019212884.1 highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W RBG2 Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; uncharacterized protein 183459 34686184 LALA0_S06e01948g Lachancea lanzarotensis uncharacterized protein XP_022628934.1 182353 D 1245769 CDS LALA0_S06e01992g 34686186 complement(184626..185654) Unknown 1 NW_019212884.1 highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; uncharacterized protein 185654 34686186 LALA0_S06e01992g Lachancea lanzarotensis uncharacterized protein XP_022628935.1 184626 R 1245769 CDS LALA0_S06e02014g 34686187 186171..186590 Unknown 1 NW_019212884.1 similar to uniprot|C5DCG1 Lachancea thermotolerans KLTH0B02772g hypothetical protein; uncharacterized protein 186590 34686187 LALA0_S06e02014g Lachancea lanzarotensis uncharacterized protein XP_022628936.1 186171 D 1245769 CDS LALA0_S06e02036g 34686188 complement(188107..188691) Unknown 1 NW_019212884.1 highly similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis; ATPase-activating ribosome biosynthesis protein 188691 34686188 LALA0_S06e02036g Lachancea lanzarotensis ATPase-activating ribosome biosynthesis protein XP_022628937.1 188107 R 1245769 CDS LALA0_S06e02058g 34686189 189086..189583 Unknown 1 NW_019212884.1 similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p; uncharacterized protein 189583 34686189 LALA0_S06e02058g Lachancea lanzarotensis uncharacterized protein XP_022628938.1 189086 D 1245769 CDS LALA0_S06e02080g 34686190 complement(189677..190510) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes; Smc5-Smc6 complex subunit NSE1 190510 34686190 LALA0_S06e02080g Lachancea lanzarotensis Smc5-Smc6 complex subunit NSE1 XP_022628939.1 189677 R 1245769 CDS LALA0_S06e02102g 34686191 192128..193960 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate; mitogen-activated protein kinase kinase kinase SSK1 193960 34686191 LALA0_S06e02102g Lachancea lanzarotensis mitogen-activated protein kinase kinase kinase SSK1 XP_022628940.1 192128 D 1245769 CDS LALA0_S06e02124g 34686192 194546..196642 Unknown 1 NW_019212884.1 similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex; uncharacterized protein 196642 34686192 LALA0_S06e02124g Lachancea lanzarotensis uncharacterized protein XP_022628941.1 194546 D 1245769 CDS LALA0_S06e02146g 34686193 complement(196724..197593) Unknown 1 NW_019212884.1 similar to uniprot|Q07897 Saccharomyces cerevisiae YLR003C CMS1 Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable; uncharacterized protein 197593 34686193 LALA0_S06e02146g Lachancea lanzarotensis uncharacterized protein XP_022628942.1 196724 R 1245769 CDS LALA0_S06e02168g 34686194 complement(197760..199331) Unknown 1 NW_019212884.1 highly similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C THI73 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; uncharacterized protein 199331 34686194 LALA0_S06e02168g Lachancea lanzarotensis uncharacterized protein XP_022628943.1 197760 R 1245769 CDS LALA0_S06e02190g 34686195 200038..202533 Unknown 1 NW_019212884.1 similar to uniprot|C5DCG6 Lachancea thermotolerans KLTH0B02904g hypothetical protein; uncharacterized protein 202533 34686195 LALA0_S06e02190g Lachancea lanzarotensis uncharacterized protein XP_022628944.1 200038 D 1245769 CDS LALA0_S06e02212g 34686196 203031..204446 Unknown 1 NW_019212884.1 highly similar to uniprot|Q04673 Saccharomyces cerevisiae YLR005W SSL1 Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p; TFIIH/NER complex subunit SSL1 204446 34686196 LALA0_S06e02212g Lachancea lanzarotensis TFIIH/NER complex subunit SSL1 XP_022628945.1 203031 D 1245769 CDS LALA0_S06e02234g 34686197 204970..206706 Unknown 1 NW_019212884.1 highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake; uncharacterized protein 206706 34686197 LALA0_S06e02234g Lachancea lanzarotensis uncharacterized protein XP_022628946.1 204970 D 1245769 CDS LALA0_S06e02278g 34686199 208346..211285 Unknown 1 NW_019212884.1 some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor; uncharacterized protein 211285 34686199 LALA0_S06e02278g Lachancea lanzarotensis uncharacterized protein XP_022628947.1 208346 D 1245769 CDS LALA0_S06e02300g 34686200 211514..213043 Unknown 1 NW_019212884.1 weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis; uncharacterized protein 213043 34686200 LALA0_S06e02300g Lachancea lanzarotensis uncharacterized protein XP_022628948.1 211514 D 1245769 CDS LALA0_S06e02322g 34686201 complement(213246..213917) Unknown 1 NW_019212884.1 similar to uniprot|C5DG07 Lachancea thermotolerans KLTH0D01452g hypothetical protein; uncharacterized protein 213917 34686201 LALA0_S06e02322g Lachancea lanzarotensis uncharacterized protein XP_022628949.1 213246 R 1245769 CDS LALA0_S06e02344g 34686202 215044..217020 Unknown 1 NW_019212884.1 similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation; uncharacterized protein 217020 34686202 LALA0_S06e02344g Lachancea lanzarotensis uncharacterized protein XP_022628950.1 215044 D 1245769 CDS LALA0_S06e02366g 34686203 complement(217289..219118) Unknown 1 NW_019212884.1 similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W MPP10 Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; rRNA-processing protein MPP10 219118 34686203 LALA0_S06e02366g Lachancea lanzarotensis rRNA-processing protein MPP10 XP_022628951.1 217289 R 1245769 CDS LALA0_S06e02388g 34686204 complement(219307..221082) Unknown 1 NW_019212884.1 similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 221082 34686204 LALA0_S06e02388g Lachancea lanzarotensis uncharacterized protein XP_022628952.1 219307 R 1245769 CDS LALA0_S06e02410g 34686205 complement(221585..222277) Unknown 1 NW_019212884.1 some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; uncharacterized protein 222277 34686205 LALA0_S06e02410g Lachancea lanzarotensis uncharacterized protein XP_022628953.1 221585 R 1245769 CDS LALA0_S06e02432g 34686206 222528..225131 Unknown 1 NW_019212884.1 similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated; uncharacterized protein 225131 34686206 LALA0_S06e02432g Lachancea lanzarotensis uncharacterized protein XP_022628954.1 222528 D 1245769 CDS LALA0_S06e02542g 34686207 complement(225425..227725) Unknown 1 NW_019212884.1 highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance; dynamin-related GTPase DNM1 227725 34686207 LALA0_S06e02542g Lachancea lanzarotensis dynamin-related GTPase DNM1 XP_022628955.1 225425 R 1245769 CDS LALA0_S06e02564g 34686208 complement(227933..229240) Unknown 1 NW_019212884.1 similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p; H3 histone acetyltransferase RTT109 229240 34686208 LALA0_S06e02564g Lachancea lanzarotensis H3 histone acetyltransferase RTT109 XP_022628956.1 227933 R 1245769 CDS LALA0_S06e02586g 34686209 complement(join(229391..229973,230035..230099)) Unknown 1 NW_019212884.1 highly similar to uniprot|P38624 Saccharomyces cerevisiae YJL001W PRE3 Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides; proteasome core particle subunit beta 1 230099 34686209 LALA0_S06e02586g Lachancea lanzarotensis proteasome core particle subunit beta 1 XP_022628957.1 229391 R 1245769 CDS LALA0_S06e02608g 34686210 complement(230273..233167) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1 Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C; uncharacterized protein 233167 34686210 LALA0_S06e02608g Lachancea lanzarotensis uncharacterized protein XP_022628958.1 230273 R 1245769 CDS LALA0_S06e02630g 34686211 233314..234729 Unknown 1 NW_019212884.1 similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 234729 34686211 LALA0_S06e02630g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 XP_022628959.1 233314 D 1245769 CDS LALA0_S06e02652g 34686212 complement(234827..236731) Unknown 1 NW_019212884.1 similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; origin recognition complex subunit 3 236731 34686212 LALA0_S06e02652g Lachancea lanzarotensis origin recognition complex subunit 3 XP_022628960.1 234827 R 1245769 CDS LALA0_S06e02674g 34686213 complement(237521..237877) Unknown 1 NW_019212884.1 highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase; uncharacterized protein 237877 34686213 LALA0_S06e02674g Lachancea lanzarotensis uncharacterized protein XP_022628961.1 237521 R 1245769 CDS LALA0_S06e02696g 34686214 complement(238560..239915) Unknown 1 NW_019212884.1 similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; ERMES complex subunit MMM1 239915 34686214 LALA0_S06e02696g Lachancea lanzarotensis ERMES complex subunit MMM1 XP_022628962.1 238560 R 1245769 CDS LALA0_S06e02718g 34686215 240230..242131 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene; uncharacterized protein 242131 34686215 LALA0_S06e02718g Lachancea lanzarotensis uncharacterized protein XP_022628963.1 240230 D 1245769 CDS LALA0_S06e02740g 34686216 complement(242212..244443) Unknown 1 NW_019212884.1 highly similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; uncharacterized protein 244443 34686216 LALA0_S06e02740g Lachancea lanzarotensis uncharacterized protein XP_022628964.1 242212 R 1245769 CDS LALA0_S06e02762g 34686217 244728..245327 Unknown 1 NW_019212884.1 highly similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation; uncharacterized protein 245327 34686217 LALA0_S06e02762g Lachancea lanzarotensis uncharacterized protein XP_022628965.1 244728 D 1245769 CDS LALA0_S06e02784g 34686218 complement(245584..251226) Unknown 1 NW_019212884.1 similar to uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase, required for cAMPproduction and cAMP-dependent protein kinase signaling;the cAMP pathway controls a variety of cellular processes,including metabolism, cell cycle, stress response,stationary phase, and sporulation; adenylate cyclase 251226 34686218 LALA0_S06e02784g Lachancea lanzarotensis adenylate cyclase XP_022628966.1 245584 R 1245769 CDS LALA0_S06e02806g 34686219 252255..252449 Unknown 1 NW_019212884.1 similar to uniprot|Q12287 Saccharomyces cerevisiae YLL009C COX17 Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; copper metallochaperone COX17 252449 34686219 LALA0_S06e02806g Lachancea lanzarotensis copper metallochaperone COX17 XP_022628967.1 252255 D 1245769 CDS LALA0_S06e02828g 34686220 252750..253712 Unknown 1 NW_019212884.1 highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression; S-methyl-5-thioadenosine phosphorylase 253712 34686220 LALA0_S06e02828g Lachancea lanzarotensis S-methyl-5-thioadenosine phosphorylase XP_022628968.1 252750 D 1245769 CDS LALA0_S06e02850g 34686221 complement(253788..254837) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex; uncharacterized protein 254837 34686221 LALA0_S06e02850g Lachancea lanzarotensis uncharacterized protein XP_022628969.1 253788 R 1245769 CDS LALA0_S06e02872g 34686222 256776..258035 Unknown 1 NW_019212884.1 similar to uniprot|Q07949 Saccharomyces cerevisiae YLR019W (ohnolog of YLL010C) PSR2 Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; phosphatase 258035 34686222 LALA0_S06e02872g Lachancea lanzarotensis phosphatase XP_022628970.1 256776 D 1245769 CDS LALA0_S06e02894g 34686223 complement(258340..259773) Unknown 1 NW_019212884.1 highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W SOF1 Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; rRNA-processing protein SOF1 259773 34686223 LALA0_S06e02894g Lachancea lanzarotensis rRNA-processing protein SOF1 XP_022628971.1 258340 R 1245769 CDS LALA0_S06e02916g 34686224 complement(259937..261454) Unknown 1 NW_019212884.1 similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C (ohnolog of YLL012W) YEH2 Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; uncharacterized protein 261454 34686224 LALA0_S06e02916g Lachancea lanzarotensis uncharacterized protein XP_022628972.1 259937 R 1245769 CDS LALA0_S06e02938g 34686225 261623..262165 Unknown 1 NW_019212884.1 similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W IRC25 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; uncharacterized protein 262165 34686225 LALA0_S06e02938g Lachancea lanzarotensis uncharacterized protein XP_022628973.1 261623 D 1245769 CDS LALA0_S06e02960g 34686226 complement(262244..262972) Unknown 1 NW_019212884.1 highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes; guanine nucleotide exchange factor SDO1 262972 34686226 LALA0_S06e02960g Lachancea lanzarotensis guanine nucleotide exchange factor SDO1 XP_022628974.1 262244 R 1245769 CDS LALA0_S06e02982g 34686227 complement(263333..265372) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; uncharacterized protein 265372 34686227 LALA0_S06e02982g Lachancea lanzarotensis uncharacterized protein XP_022628975.1 263333 R 1245769 CDS LALA0_S06e03004g 34686228 267100..269385 Unknown 1 NW_019212884.1 weakly similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors; mRNA-binding protein PUF3 269385 34686228 LALA0_S06e03004g Lachancea lanzarotensis mRNA-binding protein PUF3 XP_022628976.1 267100 D 1245769 CDS LALA0_S06e03026g 34686229 complement(269617..269940) Unknown 1 NW_019212884.1 similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W EMC6 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; uncharacterized protein 269940 34686229 LALA0_S06e03026g Lachancea lanzarotensis uncharacterized protein XP_022628977.1 269617 R 1245769 CDS LALA0_S06e03048g 34686230 270272..271420 Unknown 1 NW_019212884.1 highly similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C HGH1 Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); uncharacterized protein 271420 34686230 LALA0_S06e03048g Lachancea lanzarotensis uncharacterized protein XP_022628978.1 270272 D 1245769 CDS LALA0_S06e03070g 34686231 complement(271524..273572) Unknown 1 NW_019212884.1 similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74; transcription factor IIF subunit TFG1 273572 34686231 LALA0_S06e03070g Lachancea lanzarotensis transcription factor IIF subunit TFG1 XP_022628979.1 271524 R 1245769 CDS LALA0_S06e03092g 34686232 275157..276383 Unknown 1 NW_019212884.1 highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; tyrosine--tRNA ligase TYS1 276383 34686232 LALA0_S06e03092g Lachancea lanzarotensis tyrosine--tRNA ligase TYS1 XP_022628980.1 275157 D 1245769 CDS LALA0_S06e03114g 34686233 complement(276546..281909) Unknown 1 NW_019212884.1 similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex; uncharacterized protein 281909 34686233 LALA0_S06e03114g Lachancea lanzarotensis uncharacterized protein XP_022628981.1 276546 R 1245769 CDS LALA0_S06e03136g 34686234 282468..288287 Unknown 1 NW_019212884.1 similar to uniprot|P19812 Saccharomyces cerevisiae YGR184C UBR1 E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS); E3 ubiquitin-protein ligase UBR1 288287 34686234 LALA0_S06e03136g Lachancea lanzarotensis E3 ubiquitin-protein ligase UBR1 XP_022628982.1 282468 D 1245769 CDS LALA0_S06e03158g 34686235 join(288711..288713,288958..289161) Unknown 1 NW_019212884.1 similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex; ubiquinol--cytochrome-c reductase subunit 9 289161 34686235 LALA0_S06e03158g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit 9 XP_022628983.1 288711 D 1245769 CDS LALA0_S06e03180g 34686236 complement(289508..289828) Unknown 1 NW_019212884.1 highly similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; protein translocase subunit TIM13 289828 34686236 LALA0_S06e03180g Lachancea lanzarotensis protein translocase subunit TIM13 XP_022628984.1 289508 R 1245769 CDS LALA0_S06e03224g 34686238 join(290302..290323,290403..290956) Unknown 1 NW_019212884.1 highly similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; uncharacterized protein 290956 34686238 LALA0_S06e03224g Lachancea lanzarotensis uncharacterized protein XP_022628985.1 290302 D 1245769 CDS LALA0_S06e03246g 34686239 complement(291089..291520) Unknown 1 NW_019212884.1 similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex; uncharacterized protein 291520 34686239 LALA0_S06e03246g Lachancea lanzarotensis uncharacterized protein XP_022628986.1 291089 R 1245769 CDS LALA0_S06e03268g 34686240 complement(291872..293368) Unknown 1 NW_019212884.1 highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; squalene monooxygenase 293368 34686240 LALA0_S06e03268g Lachancea lanzarotensis squalene monooxygenase XP_022628987.1 291872 R 1245769 CDS LALA0_S06e03290g 34686241 295542..296861 Unknown 1 NW_019212884.1 similar to uniprot|G8ZZ34 Torulaspora delbrueckii TDEL_0H00190 hypothetical protein; uncharacterized protein 296861 34686241 LALA0_S06e03290g Lachancea lanzarotensis uncharacterized protein XP_022628988.1 295542 D 1245769 CDS LALA0_S06e03312g 34686242 complement(297710..299266) Unknown 1 NW_019212884.1 similar to uniprot|P40353 Saccharomyces cerevisiae YOR377W ATF1 Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation; alcohol O-acetyltransferase 299266 34686242 LALA0_S06e03312g Lachancea lanzarotensis alcohol O-acetyltransferase XP_022628989.1 297710 R 1245769 CDS LALA0_S06e03334g 34686243 complement(299786..301294) Unknown 1 NW_019212884.1 similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; uncharacterized protein 301294 34686243 LALA0_S06e03334g Lachancea lanzarotensis uncharacterized protein XP_022628990.1 299786 R 1245769 CDS LALA0_S06e03356g 34686244 complement(301669..303903) Unknown 1 NW_019212884.1 similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; uncharacterized protein 303903 34686244 LALA0_S06e03356g Lachancea lanzarotensis uncharacterized protein XP_022628991.1 301669 R 1245769 CDS LALA0_S06e03378g 34686245 complement(304409..305458) Unknown 1 NW_019212884.1 weakly similar to uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; uncharacterized protein 305458 34686245 LALA0_S06e03378g Lachancea lanzarotensis uncharacterized protein XP_022628992.1 304409 R 1245769 CDS LALA0_S06e03400g 34686246 307573..308559 Unknown 1 NW_019212884.1 highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents; thiamine thiazole synthase 308559 34686246 LALA0_S06e03400g Lachancea lanzarotensis thiamine thiazole synthase XP_022628993.1 307573 D 1245769 CDS LALA0_S06e03422g 34686247 complement(308686..310194) Unknown 1 NW_019212884.1 some similarities with uniprot|G8ZZ34 Torulaspora delbrueckii TDEL_0H00190 hypothetical protein; uncharacterized protein 310194 34686247 LALA0_S06e03422g Lachancea lanzarotensis uncharacterized protein XP_022628994.1 308686 R 1245769 CDS LALA0_S06e03444g 34686248 complement(310545..311774) Unknown 1 NW_019212884.1 highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W (ohnolog of YGR180C) RNR2 Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; uncharacterized protein 311774 34686248 LALA0_S06e03444g Lachancea lanzarotensis uncharacterized protein XP_022628995.1 310545 R 1245769 CDS LALA0_S06e03488g 34686250 complement(313187..313645) Unknown 1 NW_019212884.1 highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; nucleoside diphosphate kinase 313645 34686250 LALA0_S06e03488g Lachancea lanzarotensis nucleoside diphosphate kinase XP_022628996.1 313187 R 1245769 CDS LALA0_S06e03510g 34686251 315153..315854 Unknown 1 NW_019212884.1 some similarities with uniprot|P07249 Saccharomyces cerevisiae YMR042W ARG80 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p; uncharacterized protein 315854 34686251 LALA0_S06e03510g Lachancea lanzarotensis uncharacterized protein XP_022628997.1 315153 D 1245769 CDS LALA0_S06e03532g 34686252 316620..317930 Unknown 1 NW_019212884.1 similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif; uncharacterized protein 317930 34686252 LALA0_S06e03532g Lachancea lanzarotensis uncharacterized protein XP_022628998.1 316620 D 1245769 CDS LALA0_S06e03554g 34686253 complement(318087..321695) Unknown 1 NW_019212884.1 similar to uniprot|Q02630 Saccharomyces cerevisiae YMR047C (ohnolog of YKL068W) NUP116 Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p; FG-nucleoporin NUP116 321695 34686253 LALA0_S06e03554g Lachancea lanzarotensis FG-nucleoporin NUP116 XP_022628999.1 318087 R 1245769 CDS LALA0_S06e03576g 34686254 324676..325191 Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 325191 34686254 LALA0_S06e03576g Lachancea lanzarotensis uncharacterized protein XP_022629000.1 324676 D 1245769 CDS LALA0_S06e03598g 34686255 325654..326511 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; uncharacterized protein 326511 34686255 LALA0_S06e03598g Lachancea lanzarotensis uncharacterized protein XP_022629001.1 325654 D 1245769 CDS LALA0_S06e03620g 34686256 complement(326653..329106) Unknown 1 NW_019212884.1 highly similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1; uncharacterized protein 329106 34686256 LALA0_S06e03620g Lachancea lanzarotensis uncharacterized protein XP_022629002.1 326653 R 1245769 CDS LALA0_S06e03664g 34686258 complement(329478..330017) Unknown 1 NW_019212884.1 similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; L-methionine (R)-S-oxide reductase 330017 34686258 LALA0_S06e03664g Lachancea lanzarotensis L-methionine (R)-S-oxide reductase XP_022629003.1 329478 R 1245769 CDS LALA0_S06e03708g 34686260 330880..331491 Unknown 1 NW_019212884.1 similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; uncharacterized protein 331491 34686260 LALA0_S06e03708g Lachancea lanzarotensis uncharacterized protein XP_022629004.1 330880 D 1245769 CDS LALA0_S06e03730g 34686261 complement(331565..333847) Unknown 1 NW_019212884.1 weakly similar to uniprot|P46679 Saccharomyces cerevisiae YMR053C (ohnolog of YKL072W) STB2 Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p; uncharacterized protein 333847 34686261 LALA0_S06e03730g Lachancea lanzarotensis uncharacterized protein XP_022629005.1 331565 R 1245769 CDS LALA0_S06e03752g 34686262 join(334468..334492,334621..337214) Unknown 1 NW_019212884.1 similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; H(+)-transporting V0 sector ATPase subunit a 337214 34686262 LALA0_S06e03752g Lachancea lanzarotensis H(+)-transporting V0 sector ATPase subunit a XP_022629006.1 334468 D 1245769 CDS LALA0_S06e03774g 34686263 complement(337368..339998) Unknown 1 NW_019212884.1 similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway; Hsp70 family chaperone LHS1 339998 34686263 LALA0_S06e03774g Lachancea lanzarotensis Hsp70 family chaperone LHS1 XP_022629007.1 337368 R 1245769 CDS LALA0_S06e03796g 34686264 340224..341645 Unknown 1 NW_019212884.1 weakly similar to uniprot|P36084 Saccharomyces cerevisiae YKL074C MUD2 Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65; uncharacterized protein 341645 34686264 LALA0_S06e03796g Lachancea lanzarotensis uncharacterized protein XP_022629008.1 340224 D 1245769 CDS LALA0_S06e03818g 34686265 complement(341796..342704) Unknown 1 NW_019212884.1 highly similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; uncharacterized protein 342704 34686265 LALA0_S06e03818g Lachancea lanzarotensis uncharacterized protein XP_022629009.1 341796 R 1245769 CDS LALA0_S06e03840g 34686266 complement(join(343869..344006,344008..344226,344228..344398)) Unknown 1 NW_019212884.1 some similarities with uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein; 344398 34686266 LALA0_S06e03840g Lachancea lanzarotensis 343869 R 1245769 CDS LALA0_S06e03862g 34686267 347042..348925 Unknown 1 NW_019212884.1 similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; ferroxidase FET3 348925 34686267 LALA0_S06e03862g Lachancea lanzarotensis ferroxidase FET3 XP_022629010.1 347042 D 1245769 CDS LALA0_S06e03884g 34686268 349294..350442 Unknown 1 NW_019212884.1 similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin; uncharacterized protein 350442 34686268 LALA0_S06e03884g Lachancea lanzarotensis uncharacterized protein XP_022629011.1 349294 D 1245769 CDS LALA0_S06e03906g 34686269 complement(350497..351672) Unknown 1 NW_019212884.1 similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; uncharacterized protein 351672 34686269 LALA0_S06e03906g Lachancea lanzarotensis uncharacterized protein XP_022629012.1 350497 R 1245769 CDS LALA0_S06e03928g 34686270 351830..352177 Unknown 1 NW_019212884.1 similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; uncharacterized protein 352177 34686270 LALA0_S06e03928g Lachancea lanzarotensis uncharacterized protein XP_022629013.1 351830 D 1245769 CDS LALA0_S06e03950g 34686271 complement(352188..353111) Unknown 1 NW_019212884.1 similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability; SAM complex subunit SAM37 353111 34686271 LALA0_S06e03950g Lachancea lanzarotensis SAM complex subunit SAM37 XP_022629014.1 352188 R 1245769 CDS LALA0_S06e03972g 34686272 354070..356037 Unknown 1 NW_019212884.1 similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component; involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; cleavage polyadenylation factor subunit RNA14 356037 34686272 LALA0_S06e03972g Lachancea lanzarotensis cleavage polyadenylation factor subunit RNA14 XP_022629015.1 354070 D 1245769 CDS LALA0_S06e03994g 34686273 complement(356067..357392) Unknown 1 NW_019212884.1 highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ARG7 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; glutamate N-acetyltransferase 357392 34686273 LALA0_S06e03994g Lachancea lanzarotensis glutamate N-acetyltransferase XP_022629016.1 356067 R 1245769 CDS LALA0_S06e04016g 34686274 complement(358582..360327) Unknown 1 NW_019212884.1 similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock; glucose-inactivated glycerol proton symporter STL1 360327 34686274 LALA0_S06e04016g Lachancea lanzarotensis glucose-inactivated glycerol proton symporter STL1 XP_022629017.1 358582 R 1245769 CDS LALA0_S06e04038g 34686275 363326..363790 Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 363790 34686275 LALA0_S06e04038g Lachancea lanzarotensis uncharacterized protein XP_022629018.1 363326 D 1245769 CDS LALA0_S06e04060g 34686276 366902..370315 Unknown 1 NW_019212884.1 similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Acid trehalase required for utilization of extracellular trehalose; alpha,alpha-trehalase ATH1 370315 34686276 LALA0_S06e04060g Lachancea lanzarotensis alpha,alpha-trehalase ATH1 XP_022629019.1 366902 D 1245769 CDS LALA0_S06e04104g 34686278 join(370774..370824,370912..371421) Unknown 1 NW_019212884.1 similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; uncharacterized protein 371421 34686278 LALA0_S06e04104g Lachancea lanzarotensis uncharacterized protein XP_022629020.1 370774 D 1245769 CDS LALA0_S06e04126g 34686279 complement(371588..373960) Unknown 1 NW_019212884.1 similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport; uncharacterized protein 373960 34686279 LALA0_S06e04126g Lachancea lanzarotensis uncharacterized protein XP_022629021.1 371588 R 1245769 CDS LALA0_S06e04148g 34686280 375311..378157 Unknown 1 NW_019212884.1 similar to uniprot|P38167 Saccharomyces cerevisiae YBL101C (ohnolog of YPR030W) ECM21 Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements; uncharacterized protein 378157 34686280 LALA0_S06e04148g Lachancea lanzarotensis uncharacterized protein XP_022629022.1 375311 D 1245769 CDS LALA0_S06e04170g 34686281 complement(378249..378884) Unknown 1 NW_019212884.1 highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W SFT2 Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5; uncharacterized protein 378884 34686281 LALA0_S06e04170g Lachancea lanzarotensis uncharacterized protein XP_022629023.1 378249 R 1245769 CDS LALA0_S06e04192g 34686282 379315..380541 Unknown 1 NW_019212884.1 weakly similar to uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways; uncharacterized protein 380541 34686282 LALA0_S06e04192g Lachancea lanzarotensis uncharacterized protein XP_022629024.1 379315 D 1245769 CDS LALA0_S06e04214g 34686283 380997..383225 Unknown 1 NW_019212884.1 similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; uncharacterized protein 383225 34686283 LALA0_S06e04214g Lachancea lanzarotensis uncharacterized protein XP_022629025.1 380997 D 1245769 CDS LALA0_S06e04236g 34686284 383383..386334 Unknown 1 NW_019212884.1 similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C SEA4 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites; uncharacterized protein 386334 34686284 LALA0_S06e04236g Lachancea lanzarotensis uncharacterized protein XP_022629026.1 383383 D 1245769 CDS LALA0_S06e04258g 34686285 387280..390741 Unknown 1 NW_019212884.1 similar to uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); protein kinase C 390741 34686285 LALA0_S06e04258g Lachancea lanzarotensis protein kinase C XP_022629027.1 387280 D 1245769 CDS LALA0_S06e04280g 34686286 391002..394049 Unknown 1 NW_019212884.1 similar to uniprot|P38163 Saccharomyces cerevisiae YBL106C (ohnolog of YPR032W) SRO77 Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; uncharacterized protein 394049 34686286 LALA0_S06e04280g Lachancea lanzarotensis uncharacterized protein XP_022629028.1 391002 D 1245769 CDS LALA0_S06e04302g 34686287 394249..394836 Unknown 1 NW_019212884.1 similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene; uncharacterized protein 394836 34686287 LALA0_S06e04302g Lachancea lanzarotensis uncharacterized protein XP_022629029.1 394249 D 1245769 CDS LALA0_S06e04324g 34686288 395338..396786 Unknown 1 NW_019212884.1 similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp; dioxygenase BNA2 396786 34686288 LALA0_S06e04324g Lachancea lanzarotensis dioxygenase BNA2 XP_022629030.1 395338 D 1245769 CDS LALA0_S06e04346g 34686289 complement(396971..398575) Unknown 1 NW_019212884.1 highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome; histidine--tRNA ligase 398575 34686289 LALA0_S06e04346g Lachancea lanzarotensis histidine--tRNA ligase XP_022629031.1 396971 R 1245769 CDS LALA0_S06e04368g 34686290 complement(398836..400053) Unknown 1 NW_019212884.1 weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C AIM24 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; uncharacterized protein 400053 34686290 LALA0_S06e04368g Lachancea lanzarotensis uncharacterized protein XP_022629032.1 398836 R 1245769 CDS LALA0_S06e04390g 34686291 complement(400735..401028) Unknown 1 NW_019212884.1 similar to uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; uncharacterized protein 401028 34686291 LALA0_S06e04390g Lachancea lanzarotensis uncharacterized protein XP_022629033.1 400735 R 1245769 CDS LALA0_S06e04412g 34686292 401235..402425 Unknown 1 NW_019212884.1 similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; uncharacterized protein 402425 34686292 LALA0_S06e04412g Lachancea lanzarotensis uncharacterized protein XP_022629034.1 401235 D 1245769 CDS LALA0_S06e04434g 34686293 402843..403487 Unknown 1 NW_019212884.1 similar to uniprot|C5DDX4 Lachancea thermotolerans KLTH0C04532g hypothetical protein; uncharacterized protein 403487 34686293 LALA0_S06e04434g Lachancea lanzarotensis uncharacterized protein XP_022629035.1 402843 D 1245769 CDS LALA0_S06e04456g 34686294 404440..405453 Unknown 1 NW_019212884.1 similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; uncharacterized protein 405453 34686294 LALA0_S06e04456g Lachancea lanzarotensis uncharacterized protein XP_022629036.1 404440 D 1245769 CDS LALA0_S06e04478g 34686295 join(405770..405785,405853..406298) Unknown 1 NW_019212884.1 similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.; uncharacterized protein 406298 34686295 LALA0_S06e04478g Lachancea lanzarotensis uncharacterized protein XP_022629037.1 405770 D 1245769 CDS LALA0_S06e04500g 34686296 complement(406357..406977) Unknown 1 NW_019212884.1 similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins; mitochondrial 37S ribosomal protein uS10m 406977 34686296 LALA0_S06e04500g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS10m XP_022629038.1 406357 R 1245769 CDS LALA0_S06e04522g 34686297 407299..408213 Unknown 1 NW_019212884.1 highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; tRNA methyltransferase TRM7 408213 34686297 LALA0_S06e04522g Lachancea lanzarotensis tRNA methyltransferase TRM7 XP_022629039.1 407299 D 1245769 CDS LALA0_S06e04544g 34686298 complement(408428..410203) Unknown 1 NW_019212884.1 highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase; lysine--tRNA ligase KRS1 410203 34686298 LALA0_S06e04544g Lachancea lanzarotensis lysine--tRNA ligase KRS1 XP_022629040.1 408428 R 1245769 CDS LALA0_S06e04566g 34686299 411121..412053 Unknown 1 NW_019212884.1 similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C DET1 Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel; acid phosphatase DET1 412053 34686299 LALA0_S06e04566g Lachancea lanzarotensis acid phosphatase DET1 XP_022629041.1 411121 D 1245769 CDS LALA0_S06e04588g 34686300 412786..413532 Unknown 1 NW_019212884.1 highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; triose-phosphate isomerase TPI1 413532 34686300 LALA0_S06e04588g Lachancea lanzarotensis triose-phosphate isomerase TPI1 XP_022629042.1 412786 D 1245769 CDS LALA0_S06e04610g 34686301 complement(413893..414588) Unknown 1 NW_019212884.1 similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 414588 34686301 LALA0_S06e04610g Lachancea lanzarotensis N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 XP_022629043.1 413893 R 1245769 CDS LALA0_S06e04632g 34686302 415063..415641 Unknown 1 NW_019212884.1 weakly similar to uniprot|P38243 Saccharomyces cerevisiae YBR071W Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking; uncharacterized protein 415641 34686302 LALA0_S06e04632g Lachancea lanzarotensis uncharacterized protein XP_022629044.1 415063 D 1245769 CDS LALA0_S06e04654g 34686303 416283..419012 Unknown 1 NW_019212884.1 similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; DNA-dependent ATPase RDH54 419012 34686303 LALA0_S06e04654g Lachancea lanzarotensis DNA-dependent ATPase RDH54 XP_022629045.1 416283 D 1245769 CDS LALA0_S06e04676g 34686304 complement(419056..420927) Unknown 1 NW_019212884.1 similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W VMS1 Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans; uncharacterized protein 420927 34686304 LALA0_S06e04676g Lachancea lanzarotensis uncharacterized protein XP_022629046.1 419056 R 1245769 CDS LALA0_S06e04698g 34686305 complement(421136..422239) Unknown 1 NW_019212884.1 highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda; uroporphyrinogen decarboxylase HEM12 422239 34686305 LALA0_S06e04698g Lachancea lanzarotensis uroporphyrinogen decarboxylase HEM12 XP_022629047.1 421136 R 1245769 CDS LALA0_S06e04720g 34686306 423404..426268 Unknown 1 NW_019212884.1 similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Putative metalloprotease; uncharacterized protein 426268 34686306 LALA0_S06e04720g Lachancea lanzarotensis uncharacterized protein XP_022629048.1 423404 D 1245769 CDS LALA0_S06e04742g 34686307 complement(426493..428313) Unknown 1 NW_019212884.1 some similarities with uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]; uncharacterized protein 428313 34686307 LALA0_S06e04742g Lachancea lanzarotensis uncharacterized protein XP_022629049.1 426493 R 1245769 CDS LALA0_S06e04764g 34686308 complement(431148..434786) Unknown 1 NW_019212884.1 similar to uniprot|P53753 Saccharomyces cerevisiae YNR067C DSE4 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; endo-1,3(4)-beta-glucanase 434786 34686308 LALA0_S06e04764g Lachancea lanzarotensis endo-1,3(4)-beta-glucanase XP_022629050.1 431148 R 1245769 CDS LALA0_S06e04786g 34686309 435766..436566 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q12145 Saccharomyces cerevisiae YPR013C Putative zinc finger protein; YPR013C is not an essential gene; uncharacterized protein 436566 34686309 LALA0_S06e04786g Lachancea lanzarotensis uncharacterized protein XP_022629051.1 435766 D 1245769 CDS LALA0_S06e04808g 34686310 complement(437001..438908) Unknown 1 NW_019212884.1 similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; protein serine/threonine kinase activating protein DBF4 438908 34686310 LALA0_S06e04808g Lachancea lanzarotensis protein serine/threonine kinase activating protein DBF4 XP_022629052.1 437001 R 1245769 CDS LALA0_S06e04830g 34686311 complement(439291..439767) Unknown 1 NW_019212884.1 similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4; uncharacterized protein 439767 34686311 LALA0_S06e04830g Lachancea lanzarotensis uncharacterized protein XP_022629053.1 439291 R 1245769 CDS LALA0_S06e04852g 34686312 complement(440394..441221) Unknown 1 NW_019212884.1 highly similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 441221 34686312 LALA0_S06e04852g Lachancea lanzarotensis SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 XP_022629054.1 440394 R 1245769 CDS LALA0_S06e04874g 34686313 443712..445433 Unknown 1 NW_019212884.1 weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase; uncharacterized protein 445433 34686313 LALA0_S06e04874g Lachancea lanzarotensis uncharacterized protein XP_022629055.1 443712 D 1245769 CDS LALA0_S06e04896g 34686314 complement(445452..445817) Unknown 1 NW_019212884.1 similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene; uncharacterized protein 445817 34686314 LALA0_S06e04896g Lachancea lanzarotensis uncharacterized protein XP_022629056.1 445452 R 1245769 CDS LALA0_S06e04918g 34686315 complement(446359..447507) Unknown 1 NW_019212884.1 similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene; uncharacterized protein 447507 34686315 LALA0_S06e04918g Lachancea lanzarotensis uncharacterized protein XP_022629057.1 446359 R 1245769 CDS LALA0_S06e04940g 34686316 447773..448450 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q04839 Saccharomyces cerevisiae YMR255W GFD1 Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation; uncharacterized protein 448450 34686316 LALA0_S06e04940g Lachancea lanzarotensis uncharacterized protein XP_022629058.1 447773 D 1245769 CDS LALA0_S06e04962g 34686317 complement(448470..449441) Unknown 1 NW_019212884.1 similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W AIM39 Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 449441 34686317 LALA0_S06e04962g Lachancea lanzarotensis uncharacterized protein XP_022629059.1 448470 R 1245769 CDS LALA0_S06e04984g 34686318 complement(450050..450232) Unknown 1 NW_019212884.1 highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VII 450232 34686318 LALA0_S06e04984g Lachancea lanzarotensis cytochrome c oxidase subunit VII XP_022629060.1 450050 R 1245769 CDS LALA0_S06e05006g 34686319 complement(450510..451481) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p; ubiquitin-protein ligase PSH1 451481 34686319 LALA0_S06e05006g Lachancea lanzarotensis ubiquitin-protein ligase PSH1 XP_022629061.1 450510 R 1245769 CDS LALA0_S06e05028g 34686320 complement(452086..454431) Unknown 1 NW_019212884.1 weakly similar to uniprot|P08468 Saccharomyces cerevisiae YMR257C PET111 Mitochondrial translationalactivator specific for the COX2 mRNA; located in themitochondrial inner membrane; uncharacterized protein 454431 34686320 LALA0_S06e05028g Lachancea lanzarotensis uncharacterized protein XP_022629062.1 452086 R 1245769 CDS LALA0_S06e05050g 34686321 complement(454883..456544) Unknown 1 NW_019212884.1 similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C ROY1 GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p; uncharacterized protein 456544 34686321 LALA0_S06e05050g Lachancea lanzarotensis uncharacterized protein XP_022629063.1 454883 R 1245769 CDS LALA0_S06e05094g 34686323 complement(457108..461463) Unknown 1 NW_019212884.1 similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene; tRNA methylation protein TRM732 461463 34686323 LALA0_S06e05094g Lachancea lanzarotensis tRNA methylation protein TRM732 XP_022629064.1 457108 R 1245769 CDS LALA0_S06e05116g 34686324 462632..463702 Unknown 1 NW_019212884.1 highly similar to uniprot|C5DLS2 Lachancea thermotolerans KLTH0G03014g hypothetical protein; uncharacterized protein 463702 34686324 LALA0_S06e05116g Lachancea lanzarotensis uncharacterized protein XP_022629065.1 462632 D 1245769 CDS LALA0_S06e05138g 34686325 complement(463994..464455) Unknown 1 NW_019212884.1 highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; uncharacterized protein 464455 34686325 LALA0_S06e05138g Lachancea lanzarotensis uncharacterized protein XP_022629066.1 463994 R 1245769 CDS LALA0_S06e05160g 34686326 complement(464883..468257) Unknown 1 NW_019212884.1 similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C (ohnolog of YML100W) TPS3 Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; trehalose 6-phosphate synthase/phosphatase complex subunit 468257 34686326 LALA0_S06e05160g Lachancea lanzarotensis trehalose 6-phosphate synthase/phosphatase complex subunit XP_022629067.1 464883 R 1245769 CDS LALA0_S06e05182g 34686327 469372..470322 Unknown 1 NW_019212884.1 similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene; uncharacterized protein 470322 34686327 LALA0_S06e05182g Lachancea lanzarotensis uncharacterized protein XP_022629068.1 469372 D 1245769 CDS LALA0_S06e05204g 34686328 470475..470984 Unknown 1 NW_019212884.1 similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; uncharacterized protein 470984 34686328 LALA0_S06e05204g Lachancea lanzarotensis uncharacterized protein XP_022629069.1 470475 D 1245769 CDS LALA0_S06e05226g 34686329 471184..471798 Unknown 1 NW_019212884.1 similar to uniprot|Q04201 Saccharomyces cerevisiae YML101C (ohnolog of YMR264W) CUE4 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; uncharacterized protein 471798 34686329 LALA0_S06e05226g Lachancea lanzarotensis uncharacterized protein XP_022629070.1 471184 D 1245769 CDS LALA0_S06e05248g 34686330 complement(471839..473368) Unknown 1 NW_019212884.1 similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans; uncharacterized protein 473368 34686330 LALA0_S06e05248g Lachancea lanzarotensis uncharacterized protein XP_022629071.1 471839 R 1245769 CDS LALA0_S06e05270g 34686331 complement(473692..475107) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q03508 Saccharomyces cerevisiae YMR265C Putative protein of unknown function; uncharacterized protein 475107 34686331 LALA0_S06e05270g Lachancea lanzarotensis uncharacterized protein XP_022629072.1 473692 R 1245769 CDS LALA0_S06e05292g 34686332 476661..479369 Unknown 1 NW_019212884.1 similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane; uncharacterized protein 479369 34686332 LALA0_S06e05292g Lachancea lanzarotensis uncharacterized protein XP_022629073.1 476661 D 1245769 CDS LALA0_S06e05314g 34686333 479532..480431 Unknown 1 NW_019212884.1 similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; inorganic diphosphatase PPA2 480431 34686333 LALA0_S06e05314g Lachancea lanzarotensis inorganic diphosphatase PPA2 XP_022629074.1 479532 D 1245769 CDS LALA0_S06e05336g 34686334 480788..485650 Unknown 1 NW_019212884.1 similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p; uncharacterized protein 485650 34686334 LALA0_S06e05336g Lachancea lanzarotensis uncharacterized protein XP_022629075.1 480788 D 1245769 CDS LALA0_S06e05358g 34686335 complement(485676..486986) Unknown 1 NW_019212884.1 similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling; U6 snRNP complex subunit PRP24 486986 34686335 LALA0_S06e05358g Lachancea lanzarotensis U6 snRNP complex subunit PRP24 XP_022629076.1 485676 R 1245769 CDS LALA0_S06e05380g 34686336 487305..487913 Unknown 1 NW_019212884.1 similar to uniprot|Q03525 Saccharomyces cerevisiae YMR269W TMA23 Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan; uncharacterized protein 487913 34686336 LALA0_S06e05380g Lachancea lanzarotensis uncharacterized protein XP_022629077.1 487305 D 1245769 CDS LALA0_S06e05402g 34686337 488422..491847 Unknown 1 NW_019212884.1 similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); uncharacterized protein 491847 34686337 LALA0_S06e05402g Lachancea lanzarotensis uncharacterized protein XP_022629078.1 488422 D 1245769 CDS LALA0_S06e05424g 34686338 complement(491818..492921) Unknown 1 NW_019212884.1 similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I; uncharacterized protein 492921 34686338 LALA0_S06e05424g Lachancea lanzarotensis uncharacterized protein XP_022629079.1 491818 R 1245769 CDS LALA0_S06e05446g 34686339 493793..494569 Unknown 1 NW_019212884.1 similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; RNA-binding signal recognition particle subunit SEC65 494569 34686339 LALA0_S06e05446g Lachancea lanzarotensis RNA-binding signal recognition particle subunit SEC65 XP_022629080.1 493793 D 1245769 CDS LALA0_S06e05468g 34686340 complement(494967..495641) Unknown 1 NW_019212884.1 highly similar to uniprot|P30402 Saccharomyces cerevisiae YMR271C (ohnolog of YML106W) URA10 Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5; orotate phosphoribosyltransferase URA10 495641 34686340 LALA0_S06e05468g Lachancea lanzarotensis orotate phosphoribosyltransferase URA10 XP_022629081.1 494967 R 1245769 CDS LALA0_S06e05490g 34686341 498067..499035 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C PML39 Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes; uncharacterized protein 499035 34686341 LALA0_S06e05490g Lachancea lanzarotensis uncharacterized protein XP_022629082.1 498067 D 1245769 CDS LALA0_S06e05512g 34686342 complement(499139..500284) Unknown 1 NW_019212884.1 highly similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; fatty acid alpha-hydroxylase 500284 34686342 LALA0_S06e05512g Lachancea lanzarotensis fatty acid alpha-hydroxylase XP_022629083.1 499139 R 1245769 CDS LALA0_S06e05556g 34686344 complement(500948..503380) Unknown 1 NW_019212884.1 similar to uniprot|Q04048 Saccharomyces cerevisiae YDR416W SYF1 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans; mRNA splicing protein SYF1 503380 34686344 LALA0_S06e05556g Lachancea lanzarotensis mRNA splicing protein SYF1 XP_022629084.1 500948 R 1245769 CDS LALA0_S06e05578g 34686345 503719..504534 Unknown 1 NW_019212884.1 highly similar to uniprot|P32610 Saccharomyces cerevisiae YEL051W VMA8 Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; H(+)-transporting V1 sector ATPase subunit D 504534 34686345 LALA0_S06e05578g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit D XP_022629085.1 503719 D 1245769 CDS LALA0_S06e05600g 34686346 504702..505823 Unknown 1 NW_019212884.1 similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C Putative protein of unknown function; uncharacterized protein 505823 34686346 LALA0_S06e05600g Lachancea lanzarotensis uncharacterized protein XP_022629086.1 504702 D 1245769 CDS LALA0_S06e05622g 34686347 complement(505930..507084) Unknown 1 NW_019212884.1 highly similar to uniprot|P32611 Saccharomyces cerevisiae YEL050C RML2 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor; mitochondrial 54S ribosomal protein uL2m 507084 34686347 LALA0_S06e05622g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL2m XP_022629087.1 505930 R 1245769 CDS LALA0_S06e05644g 34686348 509366..511297 Unknown 1 NW_019212884.1 similar to uniprot|P05316 Saccharomyces cerevisiae YBR021W FUR4 Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues; uncharacterized protein 511297 34686348 LALA0_S06e05644g Lachancea lanzarotensis uncharacterized protein XP_022629088.1 509366 D 1245769 CDS LALA0_S06e05666g 34686349 512498..513637 Unknown 1 NW_019212884.1 weakly similar to uniprot|P16151 Saccharomyces cerevisiae YDR414C ERD1 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p); uncharacterized protein 513637 34686349 LALA0_S06e05666g Lachancea lanzarotensis uncharacterized protein XP_022629089.1 512498 D 1245769 CDS LALA0_S06e05688g 34686350 complement(513814..514524) Unknown 1 NW_019212884.1 similar to uniprot|Q04031 Saccharomyces cerevisiae YDR412W RRP17 Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5' end processing of pre-60S ribosomal RNA; uncharacterized protein 514524 34686350 LALA0_S06e05688g Lachancea lanzarotensis uncharacterized protein XP_022629090.1 513814 R 1245769 CDS LALA0_S06e05710g 34686351 515827..516789 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1 Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p; uncharacterized protein 516789 34686351 LALA0_S06e05710g Lachancea lanzarotensis uncharacterized protein XP_022629091.1 515827 D 1245769 CDS LALA0_S06e05732g 34686352 517282..519231 Unknown 1 NW_019212884.1 similar to uniprot|P32796 Saccharomyces cerevisiae YML042W CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes; carnitine O-acetyltransferase CAT2 519231 34686352 LALA0_S06e05732g Lachancea lanzarotensis carnitine O-acetyltransferase CAT2 XP_022629092.1 517282 D 1245769 CDS LALA0_S06e05776g 34686354 519604..520380 Unknown 1 NW_019212884.1 similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting; uncharacterized protein 520380 34686354 LALA0_S06e05776g Lachancea lanzarotensis uncharacterized protein XP_022629093.1 519604 D 1245769 CDS LALA0_S06e05798g 34686355 520648..521415 Unknown 1 NW_019212884.1 similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; protein-S-isoprenylcysteine carboxyl O-methyltransferase 521415 34686355 LALA0_S06e05798g Lachancea lanzarotensis protein-S-isoprenylcysteine carboxyl O-methyltransferase XP_022629094.1 520648 D 1245769 CDS LALA0_S06e05820g 34686356 complement(521496..524108) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q04195 Saccharomyces cerevisiae YDR409W (ohnolog of YOR156C) SIZ1 SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring; uncharacterized protein 524108 34686356 LALA0_S06e05820g Lachancea lanzarotensis uncharacterized protein XP_022629095.1 521496 R 1245769 CDS LALA0_S06e05842g 34686357 525041..525673 Unknown 1 NW_019212884.1 highly similar to uniprot|P04161 Saccharomyces cerevisiae YDR408C ADE8 Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; phosphoribosylglycinamide formyltransferase 525673 34686357 LALA0_S06e05842g Lachancea lanzarotensis phosphoribosylglycinamide formyltransferase XP_022629096.1 525041 D 1245769 CDS LALA0_S06e05864g 34686358 complement(525759..526550) Unknown 1 NW_019212884.1 highly similar to uniprot|P25043 Saccharomyces cerevisiae YOR157C PUP1 Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z; proteasome core particle subunit beta 2 526550 34686358 LALA0_S06e05864g Lachancea lanzarotensis proteasome core particle subunit beta 2 XP_022629097.1 525759 R 1245769 CDS LALA0_S06e05886g 34686359 527565..531245 Unknown 1 NW_019212884.1 similar to uniprot|Q04183 Saccharomyces cerevisiae YDR407C TRS120 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; uncharacterized protein 531245 34686359 LALA0_S06e05886g Lachancea lanzarotensis uncharacterized protein XP_022629098.1 527565 D 1245769 CDS LALA0_S06e05908g 34686360 531395..532312 Unknown 1 NW_019212884.1 similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator; uncharacterized protein 532312 34686360 LALA0_S06e05908g Lachancea lanzarotensis uncharacterized protein XP_022629099.1 531395 D 1245769 CDS LALA0_S06e05930g 34686361 complement(532432..532716) Unknown 1 NW_019212884.1 similar to uniprot|Q12330 Saccharomyces cerevisiae YOR159C SME1 Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E; mRNA splicing protein SME1 532716 34686361 LALA0_S06e05930g Lachancea lanzarotensis mRNA splicing protein SME1 XP_022629100.1 532432 R 1245769 CDS LALA0_S06e05952g 34686362 533538..536438 Unknown 1 NW_019212884.1 similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; uncharacterized protein 536438 34686362 LALA0_S06e05952g Lachancea lanzarotensis uncharacterized protein XP_022629101.1 533538 D 1245769 CDS LALA0_S06e05974g 34686363 complement(536641..538254) Unknown 1 NW_019212884.1 highly similar to uniprot|Q12412 Saccharomyces cerevisiae YOR161C PNS1 Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; uncharacterized protein 538254 34686363 LALA0_S06e05974g Lachancea lanzarotensis uncharacterized protein XP_022629102.1 536641 R 1245769 CDS LALA0_S06e05996g 34686364 539770..541059 Unknown 1 NW_019212884.1 similar to uniprot|Q99312 Saccharomyces cerevisiae YOR155C ISN1 Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms; IMP 5'-nucleotidase 541059 34686364 LALA0_S06e05996g Lachancea lanzarotensis IMP 5'-nucleotidase XP_022629103.1 539770 D 1245769 CDS LALA0_S06e06018g 34686365 541600..542106 Unknown 1 NW_019212884.1 similar to uniprot|C5DLS2 Lachancea thermotolerans KLTH0G03014g hypothetical protein; uncharacterized protein 542106 34686365 LALA0_S06e06018g Lachancea lanzarotensis uncharacterized protein XP_022629104.1 541600 D 1245769 CDS LALA0_S06e06040g 34686366 complement(542313..543056) Unknown 1 NW_019212884.1 similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL23m 543056 34686366 LALA0_S06e06040g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL23m XP_022629105.1 542313 R 1245769 CDS LALA0_S06e06062g 34686367 544268..547927 Unknown 1 NW_019212884.1 highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C RPB2 RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit; DNA-directed RNA polymerase II subunit RPB2 547927 34686367 LALA0_S06e06062g Lachancea lanzarotensis DNA-directed RNA polymerase II subunit RPB2 XP_022629106.1 544268 D 1245769 CDS LALA0_S06e06084g 34686368 complement(548181..548663) Unknown 1 NW_019212884.1 highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL13m 548663 34686368 LALA0_S06e06084g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL13m XP_022629107.1 548181 R 1245769 CDS LALA0_S06e06106g 34686369 549021..549536 Unknown 1 NW_019212884.1 highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; DNA-directed RNA polymerase II subunit RPB7 549536 34686369 LALA0_S06e06106g Lachancea lanzarotensis DNA-directed RNA polymerase II subunit RPB7 XP_022629108.1 549021 D 1245769 CDS LALA0_S06e06128g 34686370 complement(549823..551382) Unknown 1 NW_019212884.1 similar to uniprot|P21623 Saccharomyces cerevisiae YDR403W DIT1 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure; uncharacterized protein 551382 34686370 LALA0_S06e06128g Lachancea lanzarotensis uncharacterized protein XP_022629109.1 549823 R 1245769 CDS LALA0_S06e06150g 34686371 552286..553851 Unknown 1 NW_019212884.1 similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; uncharacterized protein 553851 34686371 LALA0_S06e06150g Lachancea lanzarotensis uncharacterized protein XP_022629110.1 552286 D 1245769 CDS LALA0_S06e06172g 34686372 complement(553848..554882) Unknown 1 NW_019212884.1 similar to uniprot|Q04179 Saccharomyces cerevisiae YDR400W URH1 Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase 554882 34686372 LALA0_S06e06172g Lachancea lanzarotensis trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase XP_022629111.1 553848 R 1245769 CDS LALA0_S06e06194g 34686373 555942..557408 Unknown 1 NW_019212884.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; uncharacterized protein 557408 34686373 LALA0_S06e06194g Lachancea lanzarotensis uncharacterized protein XP_022629112.1 555942 D 1245769 CDS LALA0_S06e06216g 34686374 complement(557877..558515) Unknown 1 NW_019212884.1 highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome; hypoxanthine phosphoribosyltransferase 558515 34686374 LALA0_S06e06216g Lachancea lanzarotensis hypoxanthine phosphoribosyltransferase XP_022629113.1 557877 R 1245769 CDS LALA0_S06e06238g 34686375 complement(558866..560731) Unknown 1 NW_019212884.1 similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; uncharacterized protein 560731 34686375 LALA0_S06e06238g Lachancea lanzarotensis uncharacterized protein XP_022629114.1 558866 R 1245769 CDS LALA0_S06e06260g 34686376 561607..562110 Unknown 1 NW_019212884.1 similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; negative cofactor 2 transcription regulator complex subunit NCB2 562110 34686376 LALA0_S06e06260g Lachancea lanzarotensis negative cofactor 2 transcription regulator complex subunit NCB2 XP_022629115.1 561607 D 1245769 CDS LALA0_S06e06282g 34686377 complement(562398..565247) Unknown 1 NW_019212884.1 similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; uncharacterized protein 565247 34686377 LALA0_S06e06282g Lachancea lanzarotensis uncharacterized protein XP_022629116.1 562398 R 1245769 CDS LALA0_S06e06304g 34686378 565841..567364 Unknown 1 NW_019212884.1 similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure; glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase 567364 34686378 LALA0_S06e06304g Lachancea lanzarotensis glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase XP_022629117.1 565841 D 1245769 CDS LALA0_S06e06326g 34686379 complement(567460..568752) Unknown 1 NW_019212884.1 highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B; proteasome regulatory particle base subunit RPT3 568752 34686379 LALA0_S06e06326g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT3 XP_022629118.1 567460 R 1245769 CDS LALA0_S06e06348g 34686380 complement(568955..570280) Unknown 1 NW_019212884.1 similar to uniprot|Q04172 Saccharomyces cerevisiae YDR393W SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex; uncharacterized protein 570280 34686380 LALA0_S06e06348g Lachancea lanzarotensis uncharacterized protein XP_022629119.1 568955 R 1245769 CDS LALA0_S06e06370g 34686381 570439..571068 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; uncharacterized protein 571068 34686381 LALA0_S06e06370g Lachancea lanzarotensis uncharacterized protein XP_022629120.1 570439 D 1245769 CDS LALA0_S06e06392g 34686382 complement(571168..572943) Unknown 1 NW_019212884.1 similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; uncharacterized protein 572943 34686382 LALA0_S06e06392g Lachancea lanzarotensis uncharacterized protein XP_022629121.1 571168 R 1245769 CDS LALA0_S06e06414g 34686383 573958..574788 Unknown 1 NW_019212884.1 highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain; uncharacterized protein 574788 34686383 LALA0_S06e06414g Lachancea lanzarotensis uncharacterized protein XP_022629122.1 573958 D 1245769 CDS LALA0_S06e06436g 34686384 575017..577371 Unknown 1 NW_019212884.1 weakly similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; uncharacterized protein 577371 34686384 LALA0_S06e06436g Lachancea lanzarotensis uncharacterized protein XP_022629123.1 575017 D 1245769 CDS LALA0_S06e06458g 34686385 complement(577391..578383) Unknown 1 NW_019212884.1 highly similar to uniprot|P06844 Saccharomyces cerevisiae YDR392W SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; transcriptional regulator SPT3 578383 34686385 LALA0_S06e06458g Lachancea lanzarotensis transcriptional regulator SPT3 XP_022629124.1 577391 R 1245769 CDS LALA0_S06e06480g 34686386 578709..579644 Unknown 1 NW_019212884.1 similar to uniprot|P35202 Saccharomyces cerevisiae YOR143C THI80 Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); thiamine diphosphokinase 579644 34686386 LALA0_S06e06480g Lachancea lanzarotensis thiamine diphosphokinase XP_022629125.1 578709 D 1245769 CDS LALA0_S06e06502g 34686387 580127..580582 Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 580582 34686387 LALA0_S06e06502g Lachancea lanzarotensis uncharacterized protein XP_022629126.1 580127 D 1245769 CDS LALA0_S06e06546g 34686389 complement(581205..582197) Unknown 1 NW_019212884.1 highly similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; succinate--CoA ligase (GDP-forming) subunit alpha 582197 34686389 LALA0_S06e06546g Lachancea lanzarotensis succinate--CoA ligase (GDP-forming) subunit alpha XP_022629127.1 581205 R 1245769 CDS LALA0_S06e06568g 34686390 583758..587114 Unknown 1 NW_019212884.1 similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; CCR4-NOT core subunit CAF130 587114 34686390 LALA0_S06e06568g Lachancea lanzarotensis CCR4-NOT core subunit CAF130 XP_022629128.1 583758 D 1245769 CDS LALA0_S06e06590g 34686391 587513..588391 Unknown 1 NW_019212884.1 similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; uncharacterized protein 588391 34686391 LALA0_S06e06590g Lachancea lanzarotensis uncharacterized protein XP_022629129.1 587513 D 1245769 CDS LALA0_S06e06612g 34686392 complement(588426..589745) Unknown 1 NW_019212884.1 weakly similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C URN1 Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase; uncharacterized protein 589745 34686392 LALA0_S06e06612g Lachancea lanzarotensis uncharacterized protein XP_022629130.1 588426 R 1245769 CDS LALA0_S06e06634g 34686393 590252..591004 Unknown 1 NW_019212884.1 highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; proteasome core particle subunit alpha 3 591004 34686393 LALA0_S06e06634g Lachancea lanzarotensis proteasome core particle subunit alpha 3 XP_022629131.1 590252 D 1245769 CDS LALA0_S06e06656g 34686394 join(591333..591337,591414..591707,591778..591901) Unknown 1 NW_019212884.1 similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Putative protein of unknown function; uncharacterized protein 591901 34686394 LALA0_S06e06656g Lachancea lanzarotensis uncharacterized protein XP_022629132.1 591333 D 1245769 CDS LALA0_S06e06678g 34686395 592290..593027 Unknown 1 NW_019212884.1 similar to uniprot|P53281 Saccharomyces cerevisiae YGR136W (ohnolog of YPR154W) LSB1 Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; uncharacterized protein 593027 34686395 LALA0_S06e06678g Lachancea lanzarotensis uncharacterized protein XP_022629133.1 592290 D 1245769 CDS LALA0_S06e06700g 34686396 complement(593125..594948) Unknown 1 NW_019212884.1 similar to uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p; uncharacterized protein 594948 34686396 LALA0_S06e06700g Lachancea lanzarotensis uncharacterized protein XP_022629134.1 593125 R 1245769 CDS LALA0_S06e06722g 34686397 complement(595596..596447) Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 596447 34686397 LALA0_S06e06722g Lachancea lanzarotensis uncharacterized protein XP_022629135.1 595596 R 1245769 CDS LALA0_S06e06744g 34686398 complement(598321..600231) Unknown 1 NW_019212884.1 highly similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C (ohnolog of YPR156C) TPO2 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily; spermine transporter 600231 34686398 LALA0_S06e06744g Lachancea lanzarotensis spermine transporter XP_022629136.1 598321 R 1245769 CDS LALA0_S06e06766g 34686399 602768..605206 Unknown 1 NW_019212884.1 similar to uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; uncharacterized protein 605206 34686399 LALA0_S06e06766g Lachancea lanzarotensis uncharacterized protein XP_022629137.1 602768 D 1245769 CDS LALA0_S06e06788g 34686400 605407..606738 Unknown 1 NW_019212884.1 similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W (ohnolog of YPR157W) VPS62 Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins; uncharacterized protein 606738 34686400 LALA0_S06e06788g Lachancea lanzarotensis uncharacterized protein XP_022629138.1 605407 D 1245769 CDS LALA0_S06e06810g 34686401 607273..608463 Unknown 1 NW_019212884.1 similar to uniprot|P53286 Saccharomyces cerevisiae YGR142W (ohnolog of YPR158W) BTN2 v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; uncharacterized protein 608463 34686401 LALA0_S06e06810g Lachancea lanzarotensis uncharacterized protein XP_022629139.1 607273 D 1245769 CDS LALA0_S06e06854g 34686403 609434..610405 Unknown 1 NW_019212884.1 similar to uniprot|C5DLN5 Lachancea thermotolerans KLTH0G02156g hypothetical protein; uncharacterized protein 610405 34686403 LALA0_S06e06854g Lachancea lanzarotensis uncharacterized protein XP_022629140.1 609434 D 1245769 CDS LALA0_S06e06898g 34686405 616790..618979 Unknown 1 NW_019212884.1 similar to uniprot|P33336 Saccharomyces cerevisiae YGR143W (ohnolog of YPR159W) SKN1 Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p; beta-glucan synthesis-associated protein KRE6 618979 34686405 LALA0_S06e06898g Lachancea lanzarotensis beta-glucan synthesis-associated protein KRE6 XP_022629141.1 616790 D 1245769 CDS LALA0_S06e06964g 34686408 620365..623469 Unknown 1 NW_019212884.1 similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p; MCM DNA helicase complex subunit MCM6 623469 34686408 LALA0_S06e06964g Lachancea lanzarotensis MCM DNA helicase complex subunit MCM6 XP_022629142.1 620365 D 1245769 CDS LALA0_S06e06986g 34686409 623932..626679 Unknown 1 NW_019212884.1 highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway; glycogen phosphorylase 626679 34686409 LALA0_S06e06986g Lachancea lanzarotensis glycogen phosphorylase XP_022629143.1 623932 D 1245769 CDS LALA0_S06e07008g 34686410 627311..628966 Unknown 1 NW_019212884.1 weakly similar to uniprot|P36035 Saccharomyces cerevisiae YKL217W JEN1 Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; monocarboxylate/H+ symporter 628966 34686410 LALA0_S06e07008g Lachancea lanzarotensis monocarboxylate/H+ symporter XP_022629144.1 627311 D 1245769 CDS LALA0_S06e07030g 34686411 complement(629143..630633) Unknown 1 NW_019212884.1 similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis; bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase 630633 34686411 LALA0_S06e07030g Lachancea lanzarotensis bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase XP_022629145.1 629143 R 1245769 CDS LALA0_S06e07052g 34686412 632651..634753 Unknown 1 NW_019212884.1 similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins; serine-type carboxypeptidase 634753 34686412 LALA0_S06e07052g Lachancea lanzarotensis serine-type carboxypeptidase XP_022629146.1 632651 D 1245769 CDS LALA0_S06e07074g 34686413 complement(635565..636359) Unknown 1 NW_019212884.1 similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline; CDP-diacylglycerol-serine O-phosphatidyltransferase 636359 34686413 LALA0_S06e07074g Lachancea lanzarotensis CDP-diacylglycerol-serine O-phosphatidyltransferase XP_022629147.1 635565 R 1245769 CDS LALA0_S06e07096g 34686414 complement(636923..639136) Unknown 1 NW_019212884.1 similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; acyl-CoA oxidase 639136 34686414 LALA0_S06e07096g Lachancea lanzarotensis acyl-CoA oxidase XP_022629148.1 636923 R 1245769 CDS LALA0_S06e07118g 34686415 640298..640513 Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 640513 34686415 LALA0_S06e07118g Lachancea lanzarotensis uncharacterized protein XP_022629149.1 640298 D 1245769 CDS LALA0_S06e07140g 34686416 complement(640680..641600) Unknown 1 NW_019212884.1 similar to uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein; uncharacterized protein 641600 34686416 LALA0_S06e07140g Lachancea lanzarotensis uncharacterized protein XP_022629150.1 640680 R 1245769 CDS LALA0_S06e07162g 34686417 644086..649059 Unknown 1 NW_019212884.1 highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function; clathrin heavy chain 649059 34686417 LALA0_S06e07162g Lachancea lanzarotensis clathrin heavy chain XP_022629151.1 644086 D 1245769 CDS LALA0_S06e07184g 34686418 complement(649219..652323) Unknown 1 NW_019212884.1 highly similar to uniprot|P32558 Saccharomyces cerevisiae YGL207W SPT16 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; chromatin-remodeling protein SPT16 652323 34686418 LALA0_S06e07184g Lachancea lanzarotensis chromatin-remodeling protein SPT16 XP_022629152.1 649219 R 1245769 CDS LALA0_S06e07206g 34686419 complement(652710..654104) Unknown 1 NW_019212884.1 similar to uniprot|P34164 Saccharomyces cerevisiae YGL208W (ohnolog of YER027C) SIP2 One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; uncharacterized protein 654104 34686419 LALA0_S06e07206g Lachancea lanzarotensis uncharacterized protein XP_022629153.1 652710 R 1245769 CDS LALA0_S06e07228g 34686420 complement(654579..655349) Unknown 1 NW_019212884.1 some similarities with uniprot|P53035 Saccharomyces cerevisiae YGL209W (ohnolog of YER028C) MIG2 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter; uncharacterized protein 655349 34686420 LALA0_S06e07228g Lachancea lanzarotensis uncharacterized protein XP_022629154.1 654579 R 1245769 CDS LALA0_S06e07250g 34686421 660464..661681 Unknown 1 NW_019212884.1 similar to Lachancea thermotolerans KLTH0E00308g hypothetical protein; uncharacterized protein 661681 34686421 LALA0_S06e07250g Lachancea lanzarotensis uncharacterized protein XP_022629155.1 660464 D 1245769 CDS LALA0_S06e07272g 34686422 complement(663294..663803) Unknown 1 NW_019212884.1 similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'; mRNA splicing protein SMB1 663803 34686422 LALA0_S06e07272g Lachancea lanzarotensis mRNA splicing protein SMB1 XP_022629156.1 663294 R 1245769 CDS LALA0_S06e07294g 34686423 663977..664414 Unknown 1 NW_019212884.1 similar to uniprot|P40019 Saccharomyces cerevisiae YER030W CHZ1 Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; uncharacterized protein 664414 34686423 LALA0_S06e07294g Lachancea lanzarotensis uncharacterized protein XP_022629157.1 663977 D 1245769 CDS LALA0_S06e07316g 34686424 complement(join(664527..665137,665320..665365)) Unknown 1 NW_019212884.1 highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W (ohnolog of YER031C) YPT32 Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; uncharacterized protein 665365 34686424 LALA0_S06e07316g Lachancea lanzarotensis uncharacterized protein XP_022629158.1 664527 R 1245769 CDS LALA0_S06e07338g 34686425 666857..669634 Unknown 1 NW_019212884.1 weakly similar to uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; uncharacterized protein 669634 34686425 LALA0_S06e07338g Lachancea lanzarotensis uncharacterized protein XP_022629159.1 666857 D 1245769 CDS LALA0_S06e07360g 34686426 complement(669824..672415) Unknown 1 NW_019212884.1 weakly similar to uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency; uncharacterized protein 672415 34686426 LALA0_S06e07360g Lachancea lanzarotensis uncharacterized protein XP_022629160.1 669824 R 1245769 CDS LALA0_S06e07382g 34686427 complement(672853..673974) Unknown 1 NW_019212884.1 highly similar to uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; uncharacterized protein 673974 34686427 LALA0_S06e07382g Lachancea lanzarotensis uncharacterized protein XP_022629161.1 672853 R 1245769 CDS LALA0_S06e07404g 34686428 complement(674266..675294) Unknown 1 NW_019212884.1 weakly similar to uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Vacuolar SNARE protein that functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; uncharacterized protein 675294 34686428 LALA0_S06e07404g Lachancea lanzarotensis uncharacterized protein XP_022629162.1 674266 R 1245769 CDS LALA0_S06e07426g 34686429 join(675528..675530,675641..676849) Unknown 1 NW_019212884.1 similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype; SKI complex subunit WD repeat protein SKI8 676849 34686429 LALA0_S06e07426g Lachancea lanzarotensis SKI complex subunit WD repeat protein SKI8 XP_022629163.1 675528 D 1245769 CDS LALA0_S06e07448g 34686430 complement(677268..678506) Unknown 1 NW_019212884.1 similar to uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2; uncharacterized protein 678506 34686430 LALA0_S06e07448g Lachancea lanzarotensis uncharacterized protein XP_022629164.1 677268 R 1245769 CDS LALA0_S06e07470g 34686431 complement(679949..682405) Unknown 1 NW_019212884.1 similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning; tubulin-dependent ATPase KIP3 682405 34686431 LALA0_S06e07470g Lachancea lanzarotensis tubulin-dependent ATPase KIP3 XP_022629165.1 679949 R 1245769 CDS LALA0_S06e07492g 34686432 682900..684546 Unknown 1 NW_019212884.1 similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; ERMES complex subunit MDM34 684546 34686432 LALA0_S06e07492g Lachancea lanzarotensis ERMES complex subunit MDM34 XP_022629166.1 682900 D 1245769 CDS LALA0_S06e07514g 34686433 complement(684752..685006) Unknown 1 NW_019212884.1 similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W FRA2 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel; uncharacterized protein 685006 34686433 LALA0_S06e07514g Lachancea lanzarotensis uncharacterized protein XP_022629167.1 684752 R 1245769 CDS LALA0_S06e07536g 34686434 686389..687246 Unknown 1 NW_019212884.1 similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C NIF3 Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 687246 34686434 LALA0_S06e07536g Lachancea lanzarotensis uncharacterized protein XP_022629168.1 686389 D 1245769 CDS LALA0_S06e07558g 34686435 687464..688021 Unknown 1 NW_019212884.1 similar to uniprot|P40022 Saccharomyces cerevisiae YER034W Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage; uncharacterized protein 688021 34686435 LALA0_S06e07558g Lachancea lanzarotensis uncharacterized protein XP_022629169.1 687464 D 1245769 CDS LALA0_S06e07580g 34686436 688432..689655 Unknown 1 NW_019212884.1 some similarities with uniprot|P53080 Saccharomyces cerevisiae YGL222C (ohnolog of YER035W) EDC1 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; uncharacterized protein 689655 34686436 LALA0_S06e07580g Lachancea lanzarotensis uncharacterized protein XP_022629170.1 688432 D 1245769 CDS LALA0_S06e07602g 34686437 complement(690051..691874) Unknown 1 NW_019212884.1 highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C ARB1 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; ATP-binding cassette family ATPase ARB1 691874 34686437 LALA0_S06e07602g Lachancea lanzarotensis ATP-binding cassette family ATPase ARB1 XP_022629171.1 690051 R 1245769 CDS LALA0_S06e07624g 34686438 694484..695593 Unknown 1 NW_019212884.1 highly similar to uniprot|C5E1W6 Lachancea thermotolerans KLTH0H00198g hypothetical protein; uncharacterized protein 695593 34686438 LALA0_S06e07624g Lachancea lanzarotensis uncharacterized protein XP_022629172.1 694484 D 1245769 CDS LALA0_S06e07646g 34686439 complement(696092..696607) Unknown 1 NW_019212884.1 similar to Lachancea thermotolerans KLTH0G01408g hypothetical protein; uncharacterized protein 696607 34686439 LALA0_S06e07646g Lachancea lanzarotensis uncharacterized protein XP_022629173.1 696092 R 1245769 CDS LALA0_S06e07668g 34686440 699603..701300 Unknown 1 NW_019212884.1 weakly similar to Lachancea thermotolerans KLTH0G01408g hypothetical protein; uncharacterized protein 701300 34686440 LALA0_S06e07668g Lachancea lanzarotensis uncharacterized protein XP_022629174.1 699603 D 1245769 CDS LALA0_S06e07690g 34686441 701476..702381 Unknown 1 NW_019212884.1 similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C (ohnolog of YER037W) SDT1 Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; nucleotidase 702381 34686441 LALA0_S06e07690g Lachancea lanzarotensis nucleotidase XP_022629175.1 701476 D 1245769 CDS LALA0_S06e07712g 34686442 complement(702408..703613) Unknown 1 NW_019212884.1 weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; Smc5-Smc6 complex subunit KRE29 703613 34686442 LALA0_S06e07712g Lachancea lanzarotensis Smc5-Smc6 complex subunit KRE29 XP_022629176.1 702408 R 1245769 CDS LALA0_S06e07734g 34686443 complement(703915..704901) Unknown 1 NW_019212884.1 highly similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W (ohnolog of YER039C) VRG4 Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; GDP-mannose transporter 704901 34686443 LALA0_S06e07734g Lachancea lanzarotensis GDP-mannose transporter XP_022629177.1 703915 R 1245769 CDS LALA0_S06e07756g 34686444 708267..710369 Unknown 1 NW_019212884.1 weakly similar to uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source; nitrogen-responsive transcriptional regulator GLN3 710369 34686444 LALA0_S06e07756g Lachancea lanzarotensis nitrogen-responsive transcriptional regulator GLN3 XP_022629178.1 708267 D 1245769 CDS LALA0_S06e07778g 34686445 710635..712647 Unknown 1 NW_019212884.1 weakly similar to uniprot|P40028 Saccharomyces cerevisiae YER041W YEN1 Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p; crossover junction endodeoxyribonuclease 712647 34686445 LALA0_S06e07778g Lachancea lanzarotensis crossover junction endodeoxyribonuclease XP_022629179.1 710635 D 1245769 CDS LALA0_S06e07800g 34686446 712997..713542 Unknown 1 NW_019212884.1 highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; peptide-methionine-S-sulfoxide reductase 713542 34686446 LALA0_S06e07800g Lachancea lanzarotensis peptide-methionine-S-sulfoxide reductase XP_022629180.1 712997 D 1245769 CDS LALA0_S06e07822g 34686447 complement(713556..713987) Unknown 1 NW_019212884.1 weakly similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W MTC3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1; uncharacterized protein 713987 34686447 LALA0_S06e07822g Lachancea lanzarotensis uncharacterized protein XP_022629181.1 713556 R 1245769 CDS LALA0_S06e07844g 34686448 join(714166..714189,714246..714491) Unknown 1 NW_019212884.1 similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit 714491 34686448 LALA0_S06e07844g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide--protein glycotransferase subunit XP_022629182.1 714166 D 1245769 CDS LALA0_S06e07866g 34686449 complement(714658..717282) Unknown 1 NW_019212884.1 similar to uniprot|P53076 Saccharomyces cerevisiae YGL227W VID30 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm; glucose-induced degradation complex subunit VID30 717282 34686449 LALA0_S06e07866g Lachancea lanzarotensis glucose-induced degradation complex subunit VID30 XP_022629183.1 714658 R 1245769 CDS LALA0_S06e07888g 34686450 complement(717878..719227) Unknown 1 NW_019212884.1 highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; adenosylhomocysteinase 719227 34686450 LALA0_S06e07888g Lachancea lanzarotensis adenosylhomocysteinase XP_022629184.1 717878 R 1245769 CDS LALA0_S06e07910g 34686451 complement(720386..722266) Unknown 1 NW_019212884.1 weakly similar to uniprot|P53075 Saccharomyces cerevisiae YGL228W (ohnolog of YFR039C) SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest; uncharacterized protein 722266 34686451 LALA0_S06e07910g Lachancea lanzarotensis uncharacterized protein XP_022629185.1 720386 R 1245769 CDS LALA0_S06e07932g 34686452 724005..726530 Unknown 1 NW_019212884.1 similar to uniprot|P53036 Saccharomyces cerevisiae YGL229C (ohnolog of YFR040W) SAP4 Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; uncharacterized protein 726530 34686452 LALA0_S06e07932g Lachancea lanzarotensis uncharacterized protein XP_022629186.1 724005 D 1245769 CDS LALA0_S06e07954g 34686453 complement(726720..727625) Unknown 1 NW_019212884.1 similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response; uncharacterized protein 727625 34686453 LALA0_S06e07954g Lachancea lanzarotensis uncharacterized protein XP_022629187.1 726720 R 1245769 CDS LALA0_S06e07976g 34686454 727840..728493 Unknown 1 NW_019212884.1 similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W KEG1 Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability; uncharacterized protein 728493 34686454 LALA0_S06e07976g Lachancea lanzarotensis uncharacterized protein XP_022629188.1 727840 D 1245769 CDS LALA0_S06e07998g 34686455 complement(728526..729287) Unknown 1 NW_019212884.1 weakly similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C IRC6 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; uncharacterized protein 729287 34686455 LALA0_S06e07998g Lachancea lanzarotensis uncharacterized protein XP_022629189.1 728526 R 1245769 CDS LALA0_S06e08020g 34686456 729602..730135 Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 730135 34686456 LALA0_S06e08020g Lachancea lanzarotensis uncharacterized protein XP_022629190.1 729602 D 1245769 CDS LALA0_S06e08042g 34686457 730409..730960 Unknown 1 NW_019212884.1 similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C EMC4 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis; chaperone EMC4 730960 34686457 LALA0_S06e08042g Lachancea lanzarotensis chaperone EMC4 XP_022629191.1 730409 D 1245769 CDS LALA0_S06e08064g 34686458 complement(join(731058..731849,731930..731977)) Unknown 1 NW_019212884.1 similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; uncharacterized protein 731977 34686458 LALA0_S06e08064g Lachancea lanzarotensis uncharacterized protein XP_022629192.1 731058 R 1245769 CDS LALA0_S06e08086g 34686459 complement(732229..734865) Unknown 1 NW_019212884.1 similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles; Rab GTPase-binding exocyst subunit SEC15 734865 34686459 LALA0_S06e08086g Lachancea lanzarotensis Rab GTPase-binding exocyst subunit SEC15 XP_022629193.1 732229 R 1245769 CDS LALA0_S06e08108g 34686460 complement(735967..737538) Unknown 1 NW_019212884.1 similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C DUG1 Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); metallodipeptidase 737538 34686460 LALA0_S06e08108g Lachancea lanzarotensis metallodipeptidase XP_022629194.1 735967 R 1245769 CDS LALA0_S06e08130g 34686461 join(738235..738243,738320..739282) Unknown 1 NW_019212884.1 similar to uniprot|P43617 Saccharomyces cerevisiae YFR045W Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white; uncharacterized protein 739282 34686461 LALA0_S06e08130g Lachancea lanzarotensis uncharacterized protein XP_022629195.1 738235 D 1245769 CDS LALA0_S06e08152g 34686462 complement(739382..741769) Unknown 1 NW_019212884.1 similar to uniprot|P07244 Saccharomyces cerevisiae YGL234W ADE5,7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase 741769 34686462 LALA0_S06e08152g Lachancea lanzarotensis bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase XP_022629196.1 739382 R 1245769 CDS LALA0_S06e08174g 34686463 743002..745011 Unknown 1 NW_019212884.1 similar to uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; tRNA modification protein MTO1 745011 34686463 LALA0_S06e08174g Lachancea lanzarotensis tRNA modification protein MTO1 XP_022629197.1 743002 D 1245769 CDS LALA0_S06e08196g 34686464 complement(745042..745875) Unknown 1 NW_019212884.1 hypothetical protein; uncharacterized protein 745875 34686464 LALA0_S06e08196g Lachancea lanzarotensis uncharacterized protein XP_022629198.1 745042 R 1245769 CDS LALA0_S06e08218g 34686465 746327..747193 Unknown 1 NW_019212884.1 weakly similar to uniprot|P06774 Saccharomyces cerevisiae YGL237C HAP2 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; transcription activator HAP2 747193 34686465 LALA0_S06e08218g Lachancea lanzarotensis transcription activator HAP2 XP_022629199.1 746327 D 1245769 CDS LALA0_S06e08240g 34686466 complement(747259..750138) Unknown 1 NW_019212884.1 highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation; importin-alpha export receptor 750138 34686466 LALA0_S06e08240g Lachancea lanzarotensis importin-alpha export receptor XP_022629200.1 747259 R 1245769 CDS LALA0_S06e08262g 34686467 complement(750340..751089) Unknown 1 NW_019212884.1 similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain; anaphase promoting complex subunit DOC1 751089 34686467 LALA0_S06e08262g Lachancea lanzarotensis anaphase promoting complex subunit DOC1 XP_022629201.1 750340 R 1245769 CDS LALA0_S06e08284g 34686468 complement(751664..752572) Unknown 1 NW_019212884.1 highly similar to uniprot|P43619 Saccharomyces cerevisiae YFR047C BNA6 Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; nicotinate-nucleotide diphosphorylase (carboxylating) 752572 34686468 LALA0_S06e08284g Lachancea lanzarotensis nicotinate-nucleotide diphosphorylase (carboxylating) XP_022629202.1 751664 R 1245769 CDS LALA0_S06e08306g 34686469 complement(753082..756153) Unknown 1 NW_019212884.1 similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W KAP114 Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; uncharacterized protein 756153 34686469 LALA0_S06e08306g Lachancea lanzarotensis uncharacterized protein XP_022629203.1 753082 R 1245769 CDS LALA0_S06e08328g 34686470 756391..756903 Unknown 1 NW_019212884.1 similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Putative protein of unknown function; deletion mutant is viable; uncharacterized protein 756903 34686470 LALA0_S06e08328g Lachancea lanzarotensis uncharacterized protein XP_022629204.1 756391 D 1245769 CDS LALA0_S06e08350g 34686471 complement(757009..758163) Unknown 1 NW_019212884.1 similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala; tRNA-specific adenosine deaminase 758163 34686471 LALA0_S06e08350g Lachancea lanzarotensis tRNA-specific adenosine deaminase XP_022629205.1 757009 R 1245769 CDS LALA0_S06e08372g 34686472 complement(758335..760026) Unknown 1 NW_019212884.1 similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 760026 34686472 LALA0_S06e08372g Lachancea lanzarotensis uncharacterized protein XP_022629206.1 758335 R 1245769 CDS LALA0_S06e08394g 34686473 760468..762357 Unknown 1 NW_019212884.1 similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation; uncharacterized protein 762357 34686473 LALA0_S06e08394g Lachancea lanzarotensis uncharacterized protein XP_022629207.1 760468 D 1245769 CDS LALA0_S06e08416g 34686474 complement(762445..764559) Unknown 1 NW_019212884.1 highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; glutamate--tRNA ligase GUS1 764559 34686474 LALA0_S06e08416g Lachancea lanzarotensis glutamate--tRNA ligase GUS1 XP_022629208.1 762445 R 1245769 CDS LALA0_S06e08438g 34686475 764910..766070 Unknown 1 NW_019212884.1 similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z; decapping nuclease 766070 34686475 LALA0_S06e08438g Lachancea lanzarotensis decapping nuclease XP_022629209.1 764910 D 1245769 CDS LALA0_S06e08460g 34686476 complement(766488..767039) Unknown 1 NW_019212884.1 weakly similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; uncharacterized protein 767039 34686476 LALA0_S06e08460g Lachancea lanzarotensis uncharacterized protein XP_022629210.1 766488 R 1245769 CDS LALA0_S06e08482g 34686477 767953..768333 Unknown 1 NW_019212884.1 similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W YMR31 Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36; alpha-ketoglutarate dehydrogenase subunit KGD4 768333 34686477 LALA0_S06e08482g Lachancea lanzarotensis alpha-ketoglutarate dehydrogenase subunit KGD4 XP_022629211.1 767953 D 1245769 CDS LALA0_S06e08504g 34686478 complement(768380..769462) Unknown 1 NW_019212884.1 similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation; 3',5'-cyclic-nucleotide phosphodiesterase PDE1 769462 34686478 LALA0_S06e08504g Lachancea lanzarotensis 3',5'-cyclic-nucleotide phosphodiesterase PDE1 XP_022629212.1 768380 R 1245769 CDS LALA0_S06e08526g 34686479 complement(769729..770526) Unknown 1 NW_019212884.1 highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 Beta 7 subunit of the 20S proteasome; proteasome core particle subunit beta 7 770526 34686479 LALA0_S06e08526g Lachancea lanzarotensis proteasome core particle subunit beta 7 XP_022629213.1 769729 R 1245769 CDS LALA0_S06e08548g 34686480 complement(770810..772438) Unknown 1 NW_019212884.1 similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; coatomer subunit delta 772438 34686480 LALA0_S06e08548g Lachancea lanzarotensis coatomer subunit delta XP_022629214.1 770810 R 1245769 CDS LALA0_S06e08570g 34686481 complement(772995..774092) Unknown 1 NW_019212884.1 some similarities with uniprot|P53060 Saccharomyces cerevisiae YGL250W RMR1 Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus; uncharacterized protein 774092 34686481 LALA0_S06e08570g Lachancea lanzarotensis uncharacterized protein XP_022629215.1 772995 R 1245769 CDS LALA0_S06e08592g 34686482 775141..776886 Unknown 1 NW_019212884.1 highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; uncharacterized protein 776886 34686482 LALA0_S06e08592g Lachancea lanzarotensis uncharacterized protein XP_022629216.1 775141 D 1245769 CDS LALA0_S06e08614g 34686483 777129..777926 Unknown 1 NW_019212884.1 similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; proteasome regulatory particle lid subunit RPN12 777926 34686483 LALA0_S06e08614g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN12 XP_022629217.1 777129 D 1245769 CDS LALA0_S06e08636g 34686484 complement(778161..779618) Unknown 1 NW_019212884.1 highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W (ohnolog of YFR053C) HXK2 Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; hexokinase 2 779618 34686484 LALA0_S06e08636g Lachancea lanzarotensis hexokinase 2 XP_022629218.1 778161 R 1245769 CDS LALA0_S06e08658g 34686485 complement(join(783933..784169,784173..784313)) Unknown 1 NW_019212884.1 some similarities with uniprot|B5FV78 Kluyveromyces lactis KLLA0D15576g hypothetical protein; 784313 34686485 LALA0_S06e08658g Lachancea lanzarotensis 783933 R 1245769 CDS LALA0_S07e00100g 34686486 241..1800 Unknown 1 NW_019212885.1 similar to uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; mRNA-binding protein NAB2 1800 34686486 LALA0_S07e00100g Lachancea lanzarotensis mRNA-binding protein NAB2 XP_022629219.1 241 D 1245769 CDS LALA0_S07e00122g 34686487 complement(2525..3301) Unknown 1 NW_019212885.1 highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2 Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; 40S ribosomal protein uS5 3301 34686487 LALA0_S07e00122g Lachancea lanzarotensis 40S ribosomal protein uS5 XP_022629220.1 2525 R 1245769 CDS LALA0_S07e00144g 34686488 join(4630..4637,4716..5220) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38325 Saccharomyces cerevisiae YBR230C OM14 Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron; uncharacterized protein 5220 34686488 LALA0_S07e00144g Lachancea lanzarotensis uncharacterized protein XP_022629221.1 4630 D 1245769 CDS LALA0_S07e00166g 34686489 5777..7642 Unknown 1 NW_019212885.1 similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate; uncharacterized protein 7642 34686489 LALA0_S07e00166g Lachancea lanzarotensis uncharacterized protein XP_022629222.1 5777 D 1245769 CDS LALA0_S07e00188g 34686490 complement(7727..8938) Unknown 1 NW_019212885.1 weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; uncharacterized protein 8938 34686490 LALA0_S07e00188g Lachancea lanzarotensis uncharacterized protein XP_022629223.1 7727 R 1245769 CDS LALA0_S07e00210g 34686491 9562..12336 Unknown 1 NW_019212885.1 similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; glucan 1,3-alpha-glucosidase ROT2 12336 34686491 LALA0_S07e00210g Lachancea lanzarotensis glucan 1,3-alpha-glucosidase ROT2 XP_022629224.1 9562 D 1245769 CDS LALA0_S07e00232g 34686492 complement(12354..13259) Unknown 1 NW_019212885.1 similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; endonuclease 13259 34686492 LALA0_S07e00232g Lachancea lanzarotensis endonuclease XP_022629225.1 12354 R 1245769 CDS LALA0_S07e00254g 34686493 13411..14928 Unknown 1 NW_019212885.1 similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1 Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins; uncharacterized protein 14928 34686493 LALA0_S07e00254g Lachancea lanzarotensis uncharacterized protein XP_022629226.1 13411 D 1245769 CDS LALA0_S07e00276g 34686494 complement(14980..17298) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components; uncharacterized protein 17298 34686494 LALA0_S07e00276g Lachancea lanzarotensis uncharacterized protein XP_022629227.1 14980 R 1245769 CDS LALA0_S07e00298g 34686495 complement(18082..19881) Unknown 1 NW_019212885.1 highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway; methylenetetrahydrofolate reductase (NAD(P)H) MET13 19881 34686495 LALA0_S07e00298g Lachancea lanzarotensis methylenetetrahydrofolate reductase (NAD(P)H) MET13 XP_022629228.1 18082 R 1245769 CDS LALA0_S07e00320g 34686496 21477..23201 Unknown 1 NW_019212885.1 similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI; tyrosyl-DNA phosphodiesterase 1 23201 34686496 LALA0_S07e00320g Lachancea lanzarotensis tyrosyl-DNA phosphodiesterase 1 XP_022629229.1 21477 D 1245769 CDS LALA0_S07e00342g 34686497 24011..25630 Unknown 1 NW_019212885.1 highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60 Peroxisomal protein that bindsAMP and mRNA, localizes to both the peroxisomal peripheralmembrane and matrix, expression is highly inducible byoleic acid, similar to E. coli long chain acyl-CoAsynthetase; uncharacterized protein 25630 34686497 LALA0_S07e00342g Lachancea lanzarotensis uncharacterized protein XP_022629230.1 24011 D 1245769 CDS LALA0_S07e00364g 34686498 26153..27274 Unknown 1 NW_019212885.1 highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria; pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta 27274 34686498 LALA0_S07e00364g Lachancea lanzarotensis pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta XP_022629231.1 26153 D 1245769 CDS LALA0_S07e00386g 34686499 28599..30233 Unknown 1 NW_019212885.1 similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Putative protein of unknown function; YBR220C is not an essential gene; uncharacterized protein 30233 34686499 LALA0_S07e00386g Lachancea lanzarotensis uncharacterized protein XP_022629232.1 28599 D 1245769 CDS LALA0_S07e00408g 34686500 complement(30271..31362) Unknown 1 NW_019212885.1 similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol; uncharacterized protein 31362 34686500 LALA0_S07e00408g Lachancea lanzarotensis uncharacterized protein XP_022629233.1 30271 R 1245769 CDS LALA0_S07e00430g 34686501 31671..32054 Unknown 1 NW_019212885.1 similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits; mediator complex subunit SOH1 32054 34686501 LALA0_S07e00430g Lachancea lanzarotensis mediator complex subunit SOH1 XP_022629234.1 31671 D 1245769 CDS LALA0_S07e00452g 34686502 32869..36390 Unknown 1 NW_019212885.1 highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W (ohnolog of YBR218C) PYC1 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis; pyruvate carboxylase 2 36390 34686502 LALA0_S07e00452g Lachancea lanzarotensis pyruvate carboxylase 2 XP_022629235.1 32869 D 1245769 CDS LALA0_S07e00474g 34686503 complement(36537..37145) Unknown 1 NW_019212885.1 weakly similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 37145 34686503 LALA0_S07e00474g Lachancea lanzarotensis uncharacterized protein XP_022629236.1 36537 R 1245769 CDS LALA0_S07e00496g 34686504 complement(37551..38144) Unknown 1 NW_019212885.1 similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation; uncharacterized protein 38144 34686504 LALA0_S07e00496g Lachancea lanzarotensis uncharacterized protein XP_022629237.1 37551 R 1245769 CDS LALA0_S07e00518g 34686505 38963..41047 Unknown 1 NW_019212885.1 similar to uniprot|P53169 Saccharomyces cerevisiae YGL060W (ohnolog of YBR216C) YBP2 Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p; uncharacterized protein 41047 34686505 LALA0_S07e00518g Lachancea lanzarotensis uncharacterized protein XP_022629238.1 38963 D 1245769 CDS LALA0_S07e00540g 34686506 complement(join(41083..43205,43290..43302)) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes; uncharacterized protein 43302 34686506 LALA0_S07e00540g Lachancea lanzarotensis uncharacterized protein XP_022629239.1 41083 R 1245769 CDS LALA0_S07e00562g 34686507 43433..44947 Unknown 1 NW_019212885.1 similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W PKP2 Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; protein kinase PKP2 44947 34686507 LALA0_S07e00562g Lachancea lanzarotensis protein kinase PKP2 XP_022629240.1 43433 D 1245769 CDS LALA0_S07e00584g 34686508 join(45216..45257,45329..45808) Unknown 1 NW_019212885.1 highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p; E2 ubiquitin-conjugating protein RAD6 45808 34686508 LALA0_S07e00584g Lachancea lanzarotensis E2 ubiquitin-conjugating protein RAD6 XP_022629241.1 45216 D 1245769 CDS LALA0_S07e00606g 34686509 complement(45932..46777) Unknown 1 NW_019212885.1 weakly similar to uniprot|P53171 Saccharomyces cerevisiae YGL057C GEP7 Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 46777 34686509 LALA0_S07e00606g Lachancea lanzarotensis uncharacterized protein XP_022629242.1 45932 R 1245769 CDS LALA0_S07e00628g 34686510 complement(47069..48481) Unknown 1 NW_019212885.1 similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C (ohnolog of YBR214W) SDS23 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; uncharacterized protein 48481 34686510 LALA0_S07e00628g Lachancea lanzarotensis uncharacterized protein XP_022629243.1 47069 R 1245769 CDS LALA0_S07e00650g 34686511 49741..50874 Unknown 1 NW_019212885.1 similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; uncharacterized protein 50874 34686511 LALA0_S07e00650g Lachancea lanzarotensis uncharacterized protein XP_022629244.1 49741 D 1245769 CDS LALA0_S07e00672g 34686512 51890..53566 Unknown 1 NW_019212885.1 similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease; uncharacterized protein 53566 34686512 LALA0_S07e00672g Lachancea lanzarotensis uncharacterized protein XP_022629245.1 51890 D 1245769 CDS LALA0_S07e00694g 34686513 54904..56445 Unknown 1 NW_019212885.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 56445 34686513 LALA0_S07e00694g Lachancea lanzarotensis uncharacterized protein XP_022629246.1 54904 D 1245769 CDS LALA0_S07e00716g 34686514 58913..60511 Unknown 1 NW_019212885.1 similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Delta(9) fatty acid desaturase, required formonounsaturated fatty acid synthesis and for normaldistribution of mitochondria; stearoyl-CoA 9-desaturase 60511 34686514 LALA0_S07e00716g Lachancea lanzarotensis stearoyl-CoA 9-desaturase XP_022629247.1 58913 D 1245769 CDS LALA0_S07e00738g 34686515 complement(60793..61800) Unknown 1 NW_019212885.1 similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 61800 34686515 LALA0_S07e00738g Lachancea lanzarotensis bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 XP_022629248.1 60793 R 1245769 CDS LALA0_S07e00760g 34686516 complement(62366..64243) Unknown 1 NW_019212885.1 weakly similar to uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase; uncharacterized protein 64243 34686516 LALA0_S07e00760g Lachancea lanzarotensis uncharacterized protein XP_022629249.1 62366 R 1245769 CDS LALA0_S07e00782g 34686517 66215..67216 Unknown 1 NW_019212885.1 weakly similar to uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; uncharacterized protein 67216 34686517 LALA0_S07e00782g Lachancea lanzarotensis uncharacterized protein XP_022629250.1 66215 D 1245769 CDS LALA0_S07e00804g 34686518 complement(67453..67860) Unknown 1 NW_019212885.1 highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C (ohnolog of YBR210W) ERV14 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; uncharacterized protein 67860 34686518 LALA0_S07e00804g Lachancea lanzarotensis uncharacterized protein XP_022629251.1 67453 R 1245769 CDS LALA0_S07e00848g 34686520 complement(68471..69205) Unknown 1 NW_019212885.1 similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W HRI1 Protein of unknown function that interacts with Sec72p and Hrr25p; uncharacterized protein 69205 34686520 LALA0_S07e00848g Lachancea lanzarotensis uncharacterized protein XP_022629252.1 68471 R 1245769 CDS LALA0_S07e00870g 34686521 complement(69476..73450) Unknown 1 NW_019212885.1 similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W ULS1 RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; translocase ULS1 73450 34686521 LALA0_S07e00870g Lachancea lanzarotensis translocase ULS1 XP_022629253.1 69476 R 1245769 CDS LALA0_S07e00892g 34686522 complement(74094..75419) Unknown 1 NW_019212885.1 highly similar to uniprot|P32603 Saccharomyces cerevisiae YOR190W (ohnolog of YLR300W) SPR1 Sporulation-specific exo-1,3-beta-glucanase; contributes to ascosporethermoresistance; glucan 1,3-beta-glucosidase 75419 34686522 LALA0_S07e00892g Lachancea lanzarotensis glucan 1,3-beta-glucosidase XP_022629254.1 74094 R 1245769 CDS LALA0_S07e00914g 34686523 complement(76912..77409) Unknown 1 NW_019212885.1 some similarities with uniprot|C5E2R1 Lachancea thermotolerans KLTH0H07018g hypothetical protein; uncharacterized protein 77409 34686523 LALA0_S07e00914g Lachancea lanzarotensis uncharacterized protein XP_022629255.1 76912 R 1245769 CDS LALA0_S07e00958g 34686525 complement(77751..80636) Unknown 1 NW_019212885.1 weakly similar to Lachancea thermotolerans KLTH0H07150g hypothetical protein; uncharacterized protein 80636 34686525 LALA0_S07e00958g Lachancea lanzarotensis uncharacterized protein XP_022629256.1 77751 R 1245769 CDS LALA0_S07e00980g 34686526 complement(81414..85079) Unknown 1 NW_019212885.1 similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; uncharacterized protein 85079 34686526 LALA0_S07e00980g Lachancea lanzarotensis uncharacterized protein XP_022629257.1 81414 R 1245769 CDS LALA0_S07e01002g 34686527 complement(85297..87141) Unknown 1 NW_019212885.1 similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation; gamma-glutamyltransferase 87141 34686527 LALA0_S07e01002g Lachancea lanzarotensis gamma-glutamyltransferase XP_022629258.1 85297 R 1245769 CDS LALA0_S07e01024g 34686528 complement(87518..88798) Unknown 1 NW_019212885.1 highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; translation elongation factor Tu 88798 34686528 LALA0_S07e01024g Lachancea lanzarotensis translation elongation factor Tu XP_022629259.1 87518 R 1245769 CDS LALA0_S07e01046g 34686529 89139..89831 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site; uncharacterized protein 89831 34686529 LALA0_S07e01046g Lachancea lanzarotensis uncharacterized protein XP_022629260.1 89139 D 1245769 CDS LALA0_S07e01068g 34686530 complement(91363..92754) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; uncharacterized protein 92754 34686530 LALA0_S07e01068g Lachancea lanzarotensis uncharacterized protein XP_022629261.1 91363 R 1245769 CDS LALA0_S07e01090g 34686531 93074..93523 Unknown 1 NW_019212885.1 similar to uniprot|C5E2W0 Lachancea thermotolerans KLTH0H08140g hypothetical protein; uncharacterized protein 93523 34686531 LALA0_S07e01090g Lachancea lanzarotensis uncharacterized protein XP_022629262.1 93074 D 1245769 CDS LALA0_S07e01112g 34686532 94043..96373 Unknown 1 NW_019212885.1 similar to uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes; uncharacterized protein 96373 34686532 LALA0_S07e01112g Lachancea lanzarotensis uncharacterized protein XP_022629263.1 94043 D 1245769 CDS LALA0_S07e01134g 34686533 complement(96494..99511) Unknown 1 NW_019212885.1 similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport; uncharacterized protein 99511 34686533 LALA0_S07e01134g Lachancea lanzarotensis uncharacterized protein XP_022629264.1 96494 R 1245769 CDS LALA0_S07e01156g 34686534 99644..99862 Unknown 1 NW_019212885.1 highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1- S protein involved in DNA repair; TFIIH complex subunit TFB5 99862 34686534 LALA0_S07e01156g Lachancea lanzarotensis TFIIH complex subunit TFB5 XP_022629265.1 99644 D 1245769 CDS LALA0_S07e01178g 34686535 complement(join(100016..102139,102201..102272)) Unknown 1 NW_019212885.1 similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG3 102272 34686535 LALA0_S07e01178g Lachancea lanzarotensis Golgi transport complex subunit COG3 XP_022629266.1 100016 R 1245769 CDS LALA0_S07e01200g 34686536 103228..105027 Unknown 1 NW_019212885.1 similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C (ohnolog of YPR156C) TPO2 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily; uncharacterized protein 105027 34686536 LALA0_S07e01200g Lachancea lanzarotensis uncharacterized protein XP_022629267.1 103228 D 1245769 CDS LALA0_S07e01222g 34686537 complement(105274..105591) Unknown 1 NW_019212885.1 highly similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme; uncharacterized protein 105591 34686537 LALA0_S07e01222g Lachancea lanzarotensis uncharacterized protein XP_022629268.1 105274 R 1245769 CDS LALA0_S07e01244g 34686538 105815..106900 Unknown 1 NW_019212885.1 similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1; uncharacterized protein 106900 34686538 LALA0_S07e01244g Lachancea lanzarotensis uncharacterized protein XP_022629269.1 105815 D 1245769 CDS LALA0_S07e01266g 34686539 108036..113954 Unknown 1 NW_019212885.1 similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; GTPase-activating protein BEM2 113954 34686539 LALA0_S07e01266g Lachancea lanzarotensis GTPase-activating protein BEM2 XP_022629270.1 108036 D 1245769 CDS LALA0_S07e01288g 34686540 complement(join(114186..115331,115436..115471)) Unknown 1 NW_019212885.1 similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals; membrane insertase OXA1 115471 34686540 LALA0_S07e01288g Lachancea lanzarotensis membrane insertase OXA1 XP_022629271.1 114186 R 1245769 CDS LALA0_S07e01310g 34686541 115868..116746 Unknown 1 NW_019212885.1 weakly similar to uniprot|P10355 Saccharomyces cerevisiae YER153C PET122 Mitochondrial translationalactivator specific for the COX3 mRNA, acts together withPet54p and Pet494p; located in the mitochondrial innermembrane; uncharacterized protein 116746 34686541 LALA0_S07e01310g Lachancea lanzarotensis uncharacterized protein XP_022629272.1 115868 D 1245769 CDS LALA0_S07e01332g 34686542 117163..118509 Unknown 1 NW_019212885.1 similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene; 2-aminoadipate transaminase 118509 34686542 LALA0_S07e01332g Lachancea lanzarotensis 2-aminoadipate transaminase XP_022629273.1 117163 D 1245769 CDS LALA0_S07e01354g 34686543 118781..119713 Unknown 1 NW_019212885.1 some similarities with uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p; uncharacterized protein 119713 34686543 LALA0_S07e01354g Lachancea lanzarotensis uncharacterized protein XP_022629274.1 118781 D 1245769 CDS LALA0_S07e01376g 34686544 120124..122538 Unknown 1 NW_019212885.1 similar to uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; mRNA-binding ubiquitin-specific protease UBP3 122538 34686544 LALA0_S07e01376g Lachancea lanzarotensis mRNA-binding ubiquitin-specific protease UBP3 XP_022629275.1 120124 D 1245769 CDS LALA0_S07e01398g 34686545 complement(124221..124979) Unknown 1 NW_019212885.1 weakly similar to uniprot|P40092 Saccharomyces cerevisiae YER150W (ohnolog of YDR077W) SPI1 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p; uncharacterized protein 124979 34686545 LALA0_S07e01398g Lachancea lanzarotensis uncharacterized protein XP_022629276.1 124221 R 1245769 CDS LALA0_S07e01420g 34686546 complement(126120..127325) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p; uncharacterized protein 127325 34686546 LALA0_S07e01420g Lachancea lanzarotensis uncharacterized protein XP_022629277.1 126120 R 1245769 CDS LALA0_S07e01442g 34686547 complement(127644..128567) Unknown 1 NW_019212885.1 highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes; phosphoprotein phosphatase PP4 catalytic subunit PPH3 128567 34686547 LALA0_S07e01442g Lachancea lanzarotensis phosphoprotein phosphatase PP4 catalytic subunit PPH3 XP_022629278.1 127644 R 1245769 CDS LALA0_S07e01464g 34686548 128875..129978 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth; uncharacterized protein 129978 34686548 LALA0_S07e01464g Lachancea lanzarotensis uncharacterized protein XP_022629279.1 128875 D 1245769 CDS LALA0_S07e01486g 34686549 complement(130127..130819) Unknown 1 NW_019212885.1 highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; TATA-binding protein 130819 34686549 LALA0_S07e01486g Lachancea lanzarotensis TATA-binding protein XP_022629280.1 130127 R 1245769 CDS LALA0_S07e01508g 34686550 131181..133022 Unknown 1 NW_019212885.1 similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX; cohesin-loading factor complex subunit SCC4 133022 34686550 LALA0_S07e01508g Lachancea lanzarotensis cohesin-loading factor complex subunit SCC4 XP_022629281.1 131181 D 1245769 CDS LALA0_S07e01530g 34686551 complement(133082..135826) Unknown 1 NW_019212885.1 similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; trehalose-phosphatase TPS2 135826 34686551 LALA0_S07e01530g Lachancea lanzarotensis trehalose-phosphatase TPS2 XP_022629282.1 133082 R 1245769 CDS LALA0_S07e01552g 34686552 complement(136188..136499) Unknown 1 NW_019212885.1 some similarities with uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; uncharacterized protein 136499 34686552 LALA0_S07e01552g Lachancea lanzarotensis uncharacterized protein XP_022629283.1 136188 R 1245769 CDS LALA0_S07e01574g 34686553 140056..141600 Unknown 1 NW_019212885.1 similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin; inositolphosphotransferase 141600 34686553 LALA0_S07e01574g Lachancea lanzarotensis inositolphosphotransferase XP_022629284.1 140056 D 1245769 CDS LALA0_S07e01596g 34686554 complement(141899..142144) Unknown 1 NW_019212885.1 similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; RNA-binding protein LSM5 142144 34686554 LALA0_S07e01596g Lachancea lanzarotensis RNA-binding protein LSM5 XP_022629285.1 141899 R 1245769 CDS LALA0_S07e01618g 34686555 142939..143526 Unknown 1 NW_019212885.1 similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; polyamine acetyltransferase 143526 34686555 LALA0_S07e01618g Lachancea lanzarotensis polyamine acetyltransferase XP_022629286.1 142939 D 1245769 CDS LALA0_S07e01640g 34686556 144157..144456 Unknown 1 NW_019212885.1 similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 144456 34686556 LALA0_S07e01640g Lachancea lanzarotensis uncharacterized protein XP_022629287.1 144157 D 1245769 CDS LALA0_S07e01662g 34686557 145650..148238 Unknown 1 NW_019212885.1 similar to uniprot|P39944 Saccharomyces cerevisiae YER144C (ohnolog of YDR069C) UBP5 Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck; ubiquitin-specific protease DOA4 148238 34686557 LALA0_S07e01662g Lachancea lanzarotensis ubiquitin-specific protease DOA4 XP_022629288.1 145650 D 1245769 CDS LALA0_S07e01684g 34686558 complement(148357..149238) Unknown 1 NW_019212885.1 similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 149238 34686558 LALA0_S07e01684g Lachancea lanzarotensis uncharacterized protein XP_022629289.1 148357 R 1245769 CDS LALA0_S07e01706g 34686559 149447..150154 Unknown 1 NW_019212885.1 similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C OCA6 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT; protein-tyrosine-phosphatase 150154 34686559 LALA0_S07e01706g Lachancea lanzarotensis protein-tyrosine-phosphatase XP_022629290.1 149447 D 1245769 CDS LALA0_S07e01728g 34686560 150740..151570 Unknown 1 NW_019212885.1 similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; DNA-3-methyladenine glycosylase II 151570 34686560 LALA0_S07e01728g Lachancea lanzarotensis DNA-3-methyladenine glycosylase II XP_022629291.1 150740 D 1245769 CDS LALA0_S07e01750g 34686561 complement(151646..153100) Unknown 1 NW_019212885.1 similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase; uncharacterized protein 153100 34686561 LALA0_S07e01750g Lachancea lanzarotensis uncharacterized protein XP_022629292.1 151646 R 1245769 CDS LALA0_S07e01772g 34686562 complement(153310..154836) Unknown 1 NW_019212885.1 similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins; uncharacterized protein 154836 34686562 LALA0_S07e01772g Lachancea lanzarotensis uncharacterized protein XP_022629293.1 153310 R 1245769 CDS LALA0_S07e01794g 34686563 156500..157183 Unknown 1 NW_019212885.1 similar to uniprot|P40084 Saccharomyces cerevisiae YER139C (ohnolog of YDR066C) RTR1 CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; uncharacterized protein 157183 34686563 LALA0_S07e01794g Lachancea lanzarotensis uncharacterized protein XP_022629294.1 156500 D 1245769 CDS LALA0_S07e01816g 34686564 complement(157215..158324) Unknown 1 NW_019212885.1 similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W RRG1 Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 158324 34686564 LALA0_S07e01816g Lachancea lanzarotensis uncharacterized protein XP_022629295.1 157215 R 1245769 CDS LALA0_S07e01838g 34686565 complement(join(158604..159038,159468..159488)) Unknown 1 NW_019212885.1 highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins; 40S ribosomal protein uS15 159488 34686565 LALA0_S07e01838g Lachancea lanzarotensis 40S ribosomal protein uS15 XP_022629296.1 158604 R 1245769 CDS LALA0_S07e01860g 34686566 complement(160325..160765) Unknown 1 NW_019212885.1 similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W AIM7 Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss; uncharacterized protein 160765 34686566 LALA0_S07e01860g Lachancea lanzarotensis uncharacterized protein XP_022629297.1 160325 R 1245769 CDS LALA0_S07e01882g 34686567 complement(161262..162950) Unknown 1 NW_019212885.1 highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; serine C-palmitoyltransferase LCB2 162950 34686567 LALA0_S07e01882g Lachancea lanzarotensis serine C-palmitoyltransferase LCB2 XP_022629298.1 161262 R 1245769 CDS LALA0_S07e01904g 34686568 complement(163222..164802) Unknown 1 NW_019212885.1 similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; uncharacterized protein 164802 34686568 LALA0_S07e01904g Lachancea lanzarotensis uncharacterized protein XP_022629299.1 163222 R 1245769 CDS LALA0_S07e01926g 34686569 complement(165062..167239) Unknown 1 NW_019212885.1 similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family; uncharacterized protein 167239 34686569 LALA0_S07e01926g Lachancea lanzarotensis uncharacterized protein XP_022629300.1 165062 R 1245769 CDS LALA0_S07e01948g 34686570 169112..170455 Unknown 1 NW_019212885.1 highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; uncharacterized protein 170455 34686570 LALA0_S07e01948g Lachancea lanzarotensis uncharacterized protein XP_022629301.1 169112 D 1245769 CDS LALA0_S07e01970g 34686571 join(170922..170975,171048..171284) Unknown 1 NW_019212885.1 highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; Sm-like protein LSM2 171284 34686571 LALA0_S07e01970g Lachancea lanzarotensis Sm-like protein LSM2 XP_022629302.1 170922 D 1245769 CDS LALA0_S07e01992g 34686572 complement(171469..171927) Unknown 1 NW_019212885.1 weakly similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Putative protein of unknown function; uncharacterized protein 171927 34686572 LALA0_S07e01992g Lachancea lanzarotensis uncharacterized protein XP_022629303.1 171469 R 1245769 CDS LALA0_S07e02014g 34686573 173023..173433 Unknown 1 NW_019212885.1 similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I; uncharacterized protein 173433 34686573 LALA0_S07e02014g Lachancea lanzarotensis uncharacterized protein XP_022629304.1 173023 D 1245769 CDS LALA0_S07e02036g 34686574 173700..175751 Unknown 1 NW_019212885.1 highly similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W NCL1 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120; tRNA (cytosine-C5-)-methyltransferase 175751 34686574 LALA0_S07e02036g Lachancea lanzarotensis tRNA (cytosine-C5-)-methyltransferase XP_022629305.1 173700 D 1245769 CDS LALA0_S07e02058g 34686575 complement(175864..178422) Unknown 1 NW_019212885.1 highly similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; MCM DNA helicase complex subunit MCM2 178422 34686575 LALA0_S07e02058g Lachancea lanzarotensis MCM DNA helicase complex subunit MCM2 XP_022629306.1 175864 R 1245769 CDS LALA0_S07e02080g 34686576 180405..181556 Unknown 1 NW_019212885.1 similar to Lachancea thermotolerans KLTH0G09680g hypothetical protein; uncharacterized protein 181556 34686576 LALA0_S07e02080g Lachancea lanzarotensis uncharacterized protein XP_022629307.1 180405 D 1245769 CDS LALA0_S07e02102g 34686577 complement(181584..183071) Unknown 1 NW_019212885.1 similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; uncharacterized protein 183071 34686577 LALA0_S07e02102g Lachancea lanzarotensis uncharacterized protein XP_022629308.1 181584 R 1245769 CDS LALA0_S07e02124g 34686578 complement(183320..186610) Unknown 1 NW_019212885.1 similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; ATP-dependent Lon protease PIM1 186610 34686578 LALA0_S07e02124g Lachancea lanzarotensis ATP-dependent Lon protease PIM1 XP_022629309.1 183320 R 1245769 CDS LALA0_S07e02146g 34686579 complement(187340..187855) Unknown 1 NW_019212885.1 similar to uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding; uncharacterized protein 187855 34686579 LALA0_S07e02146g Lachancea lanzarotensis uncharacterized protein XP_022629310.1 187340 R 1245769 CDS LALA0_S07e02168g 34686580 188098..189801 Unknown 1 NW_019212885.1 similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; glycolipid translocation protein 189801 34686580 LALA0_S07e02168g Lachancea lanzarotensis glycolipid translocation protein XP_022629311.1 188098 D 1245769 CDS LALA0_S07e02190g 34686581 189872..191422 Unknown 1 NW_019212885.1 similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII; DNA-(apurinic or apyrimidinic site) lyase APN2 191422 34686581 LALA0_S07e02190g Lachancea lanzarotensis DNA-(apurinic or apyrimidinic site) lyase APN2 XP_022629312.1 189872 D 1245769 CDS LALA0_S07e02212g 34686582 complement(191477..191788) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; ribonuclease P 191788 34686582 LALA0_S07e02212g Lachancea lanzarotensis ribonuclease P XP_022629313.1 191477 R 1245769 CDS LALA0_S07e02234g 34686583 complement(192253..196764) Unknown 1 NW_019212885.1 similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; type I sorting receptor 196764 34686583 LALA0_S07e02234g Lachancea lanzarotensis type I sorting receptor XP_022629314.1 192253 R 1245769 CDS LALA0_S07e02256g 34686584 197952..199007 Unknown 1 NW_019212885.1 highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation; mitogen-activated serine/threonine-protein kinase FUS3 199007 34686584 LALA0_S07e02256g Lachancea lanzarotensis mitogen-activated serine/threonine-protein kinase FUS3 XP_022629315.1 197952 D 1245769 CDS LALA0_S07e02278g 34686585 complement(199905..201023) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 201023 34686585 LALA0_S07e02278g Lachancea lanzarotensis uncharacterized protein XP_022629316.1 199905 R 1245769 CDS LALA0_S07e02300g 34686586 202578..203540 Unknown 1 NW_019212885.1 similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance; arginase 203540 34686586 LALA0_S07e02300g Lachancea lanzarotensis arginase XP_022629317.1 202578 D 1245769 CDS LALA0_S07e02322g 34686587 203962..204414 Unknown 1 NW_019212885.1 similar to uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit AC19, common to RNA polymerases I and III; DNA-directed RNA polymerase core subunit RPC19 204414 34686587 LALA0_S07e02322g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPC19 XP_022629318.1 203962 D 1245769 CDS LALA0_S07e02344g 34686588 205101..206669 Unknown 1 NW_019212885.1 similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; guanosine diphosphatase 206669 34686588 LALA0_S07e02344g Lachancea lanzarotensis guanosine diphosphatase XP_022629319.1 205101 D 1245769 CDS LALA0_S07e02366g 34686589 207194..208792 Unknown 1 NW_019212885.1 similar to uniprot|P32622 Saccharomyces cerevisiae YEL041W (ohnolog of YJR049C) YEF1 ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes; NADH/NAD(+) kinase 208792 34686589 LALA0_S07e02366g Lachancea lanzarotensis NADH/NAD(+) kinase XP_022629320.1 207194 D 1245769 CDS LALA0_S07e02388g 34686590 209002..210351 Unknown 1 NW_019212885.1 similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck; chitin transglycosylase UTR2 210351 34686590 LALA0_S07e02388g Lachancea lanzarotensis chitin transglycosylase UTR2 XP_022629321.1 209002 D 1245769 CDS LALA0_S07e02410g 34686591 complement(210783..211115) Unknown 1 NW_019212885.1 highly similar to uniprot|P00045 Saccharomyces cerevisiae YEL039C (ohnolog of YJR048W CYC1) CYC7 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; cytochrome c isoform 2 211115 34686591 LALA0_S07e02410g Lachancea lanzarotensis cytochrome c isoform 2 XP_022629322.1 210783 R 1245769 CDS LALA0_S07e02432g 34686592 212162..212821 Unknown 1 NW_019212885.1 similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus; uncharacterized protein 212821 34686592 LALA0_S07e02432g Lachancea lanzarotensis uncharacterized protein XP_022629323.1 212162 D 1245769 CDS LALA0_S07e02454g 34686593 complement(212902..214113) Unknown 1 NW_019212885.1 similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23 Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; uncharacterized protein 214113 34686593 LALA0_S07e02454g Lachancea lanzarotensis uncharacterized protein XP_022629324.1 212902 R 1245769 CDS LALA0_S07e02476g 34686594 complement(214895..216421) Unknown 1 NW_019212885.1 similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; uncharacterized protein 216421 34686594 LALA0_S07e02476g Lachancea lanzarotensis uncharacterized protein XP_022629325.1 214895 R 1245769 CDS LALA0_S07e02498g 34686595 218595..219068 Unknown 1 NW_019212885.1 highly similar to uniprot|P23301 Saccharomyces cerevisiae YEL034W (ohnolog of YJR047C ANB1) HYP2 Translation elongation factor eIF-5A that may function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; translation elongation factor eIF-5A 219068 34686595 LALA0_S07e02498g Lachancea lanzarotensis translation elongation factor eIF-5A XP_022629326.1 218595 D 1245769 CDS LALA0_S07e02520g 34686596 219853..222708 Unknown 1 NW_019212885.1 similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; MCM DNA helicase complex subunit MCM3 222708 34686596 LALA0_S07e02520g Lachancea lanzarotensis MCM DNA helicase complex subunit MCM3 XP_022629327.1 219853 D 1245769 CDS LALA0_S07e02542g 34686597 223755..227375 Unknown 1 NW_019212885.1 highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; ion-transporting P-type ATPase SPF1 227375 34686597 LALA0_S07e02542g Lachancea lanzarotensis ion-transporting P-type ATPase SPF1 XP_022629328.1 223755 D 1245769 CDS LALA0_S07e02564g 34686598 complement(227799..229505) Unknown 1 NW_019212885.1 similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 DNA replication licensing factor, required for pre-replication complex assembly; uncharacterized protein 229505 34686598 LALA0_S07e02564g Lachancea lanzarotensis uncharacterized protein XP_022629329.1 227799 R 1245769 CDS LALA0_S07e02586g 34686599 229693..231435 Unknown 1 NW_019212885.1 similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; ATP-dependent DNA helicase YKU70 231435 34686599 LALA0_S07e02586g Lachancea lanzarotensis ATP-dependent DNA helicase YKU70 XP_022629330.1 229693 D 1245769 CDS LALA0_S07e02608g 34686600 complement(231512..233011) Unknown 1 NW_019212885.1 similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C (ohnolog of YML118W) NGL2 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; RNA exonuclease 233011 34686600 LALA0_S07e02608g Lachancea lanzarotensis RNA exonuclease XP_022629331.1 231512 R 1245769 CDS LALA0_S07e02630g 34686601 233418..233672 Unknown 1 NW_019212885.1 highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL30m 233672 34686601 LALA0_S07e02630g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL30m XP_022629332.1 233418 D 1245769 CDS LALA0_S07e02652g 34686602 complement(233811..234773) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q03208 Saccharomyces cerevisiae YML119W Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate; uncharacterized protein 234773 34686602 LALA0_S07e02652g Lachancea lanzarotensis uncharacterized protein XP_022629333.1 233811 R 1245769 CDS LALA0_S07e02674g 34686603 complement(235338..238157) Unknown 1 NW_019212885.1 similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C DSS1 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs; exoribonuclease II 238157 34686603 LALA0_S07e02674g Lachancea lanzarotensis exoribonuclease II XP_022629334.1 235338 R 1245769 CDS LALA0_S07e02696g 34686604 complement(239469..240233) Unknown 1 NW_019212885.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 240233 34686604 LALA0_S07e02696g Lachancea lanzarotensis uncharacterized protein XP_022629335.1 239469 R 1245769 CDS LALA0_S07e02718g 34686605 241510..243759 Unknown 1 NW_019212885.1 similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A; 6-phosphofructo-2-kinase 243759 34686605 LALA0_S07e02718g Lachancea lanzarotensis 6-phosphofructo-2-kinase XP_022629336.1 241510 D 1245769 CDS LALA0_S07e02740g 34686606 complement(243882..245954) Unknown 1 NW_019212885.1 similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Putative metalloprotease; uncharacterized protein 245954 34686606 LALA0_S07e02740g Lachancea lanzarotensis uncharacterized protein XP_022629337.1 243882 R 1245769 CDS LALA0_S07e02762g 34686607 246381..249122 Unknown 1 NW_019212885.1 similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C (ohnolog of YNL049C) SEC24 Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p; COPII subunit SEC24 249122 34686607 LALA0_S07e02762g Lachancea lanzarotensis COPII subunit SEC24 XP_022629338.1 246381 D 1245769 CDS LALA0_S07e02784g 34686608 249316..250251 Unknown 1 NW_019212885.1 weakly similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C Putative protein of unknown function; YNL050c is not an essential gene; uncharacterized protein 250251 34686608 LALA0_S07e02784g Lachancea lanzarotensis uncharacterized protein XP_022629339.1 249316 D 1245769 CDS LALA0_S07e02806g 34686609 complement(250328..251500) Unknown 1 NW_019212885.1 similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG5 251500 34686609 LALA0_S07e02806g Lachancea lanzarotensis Golgi transport complex subunit COG5 XP_022629340.1 250328 R 1245769 CDS LALA0_S07e02828g 34686610 complement(251792..252934) Unknown 1 NW_019212885.1 similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W HPM1 AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance; protein-histidine N-methyltransferase 252934 34686610 LALA0_S07e02828g Lachancea lanzarotensis protein-histidine N-methyltransferase XP_022629341.1 251792 R 1245769 CDS LALA0_S07e02850g 34686611 complement(join(253369..253820,254175)) Unknown 1 NW_019212885.1 highly similar to uniprot|P00425 Saccharomyces cerevisiae YIL111W (ohnolog of YNL052W) COX5B Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; uncharacterized protein 254175 34686611 LALA0_S07e02850g Lachancea lanzarotensis uncharacterized protein XP_022629342.1 253369 R 1245769 CDS LALA0_S07e02872g 34686612 complement(254466..257801) Unknown 1 NW_019212885.1 similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate; uncharacterized protein 257801 34686612 LALA0_S07e02872g Lachancea lanzarotensis uncharacterized protein XP_022629343.1 254466 R 1245769 CDS LALA0_S07e02894g 34686613 complement(258152..259483) Unknown 1 NW_019212885.1 weakly similar to uniprot|P40479 Saccharomyces cerevisiae YIL113W (ohnolog of YNL053W) SDP1 Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; mitogen-activated protein kinase tyrosine protein phosphatase SDP1 259483 34686613 LALA0_S07e02894g Lachancea lanzarotensis mitogen-activated protein kinase tyrosine protein phosphatase SDP1 XP_022629344.1 258152 R 1245769 CDS LALA0_S07e02916g 34686614 complement(260399..262507) Unknown 1 NW_019212885.1 similar to Lachancea thermotolerans KLTH0C02156g hypothetical protein; uncharacterized protein 262507 34686614 LALA0_S07e02916g Lachancea lanzarotensis uncharacterized protein XP_022629345.1 260399 R 1245769 CDS LALA0_S07e02938g 34686615 265230..268523 Unknown 1 NW_019212885.1 similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; uncharacterized protein 268523 34686615 LALA0_S07e02938g Lachancea lanzarotensis uncharacterized protein XP_022629346.1 265230 D 1245769 CDS LALA0_S07e02960g 34686616 complement(268616..269314) Unknown 1 NW_019212885.1 similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6; uncharacterized protein 269314 34686616 LALA0_S07e02960g Lachancea lanzarotensis uncharacterized protein XP_022629347.1 268616 R 1245769 CDS LALA0_S07e02982g 34686617 269957..270892 Unknown 1 NW_019212885.1 highly similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin subunit PHB2 270892 34686617 LALA0_S07e02982g Lachancea lanzarotensis prohibitin subunit PHB2 XP_022629348.1 269957 D 1245769 CDS LALA0_S07e03004g 34686618 complement(271367..271630) Unknown 1 NW_019212885.1 some similarities with uniprot|P17123 Saccharomyces cerevisiae YHR152W (ohnolog of YGR230W) SPO12 Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; uncharacterized protein 271630 34686618 LALA0_S07e03004g Lachancea lanzarotensis uncharacterized protein XP_022629349.1 271367 R 1245769 CDS LALA0_S07e03026g 34686619 join(273205..274522,274607..275202) Unknown 1 NW_019212885.1 similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; uncharacterized protein 275202 34686619 LALA0_S07e03026g Lachancea lanzarotensis uncharacterized protein XP_022629350.1 273205 D 1245769 CDS LALA0_S07e03048g 34686620 275443..277071 Unknown 1 NW_019212885.1 similar to uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; uncharacterized protein 277071 34686620 LALA0_S07e03048g Lachancea lanzarotensis uncharacterized protein XP_022629351.1 275443 D 1245769 CDS LALA0_S07e03070g 34686621 complement(277176..278699) Unknown 1 NW_019212885.1 similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C MTC6 Protein of unknown function; mtc6 is synthetically sick with cdc13-1; uncharacterized protein 278699 34686621 LALA0_S07e03070g Lachancea lanzarotensis uncharacterized protein XP_022629352.1 277176 R 1245769 CDS LALA0_S07e03092g 34686622 278986..280503 Unknown 1 NW_019212885.1 similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase 280503 34686622 LALA0_S07e03092g Lachancea lanzarotensis dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase XP_022629353.1 278986 D 1245769 CDS LALA0_S07e03114g 34686623 complement(280627..282210) Unknown 1 NW_019212885.1 similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity; uncharacterized protein 282210 34686623 LALA0_S07e03114g Lachancea lanzarotensis uncharacterized protein XP_022629354.1 280627 R 1245769 CDS LALA0_S07e03136g 34686624 283665..284915 Unknown 1 NW_019212885.1 similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization; uncharacterized protein 284915 34686624 LALA0_S07e03136g Lachancea lanzarotensis uncharacterized protein XP_022629355.1 283665 D 1245769 CDS LALA0_S07e03158g 34686625 complement(284986..285798) Unknown 1 NW_019212885.1 similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; uncharacterized protein 285798 34686625 LALA0_S07e03158g Lachancea lanzarotensis uncharacterized protein XP_022629356.1 284986 R 1245769 CDS LALA0_S07e03202g 34686627 287025..289031 Unknown 1 NW_019212885.1 weakly similar to uniprot|P32900 Saccharomyces cerevisiae YHR149C (ohnolog of YGR221C) SKG6 Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; uncharacterized protein 289031 34686627 LALA0_S07e03202g Lachancea lanzarotensis uncharacterized protein XP_022629357.1 287025 D 1245769 CDS LALA0_S07e03224g 34686628 complement(289242..289793) Unknown 1 NW_019212885.1 highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; snoRNA-binding rRNA-processing protein IMP3 289793 34686628 LALA0_S07e03224g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein IMP3 XP_022629358.1 289242 R 1245769 CDS LALA0_S07e03246g 34686629 290794..291465 Unknown 1 NW_019212885.1 similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL6m 291465 34686629 LALA0_S07e03246g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL6m XP_022629359.1 290794 D 1245769 CDS LALA0_S07e03268g 34686630 291937..292743 Unknown 1 NW_019212885.1 highly similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL3m 292743 34686630 LALA0_S07e03268g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL3m XP_022629360.1 291937 D 1245769 CDS LALA0_S07e03290g 34686631 complement(292952..296206) Unknown 1 NW_019212885.1 highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin; exportin CRM1 296206 34686631 LALA0_S07e03290g Lachancea lanzarotensis exportin CRM1 XP_022629361.1 292952 R 1245769 CDS LALA0_S07e03312g 34686632 complement(296927..302959) Unknown 1 NW_019212885.1 similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together; uncharacterized protein 302959 34686632 LALA0_S07e03312g Lachancea lanzarotensis uncharacterized protein XP_022629362.1 296927 R 1245769 CDS LALA0_S07e03334g 34686633 304026..305837 Unknown 1 NW_019212885.1 similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs; phosphatidylinositol N-acetylglucosaminyltransferase 305837 34686633 LALA0_S07e03334g Lachancea lanzarotensis phosphatidylinositol N-acetylglucosaminyltransferase XP_022629363.1 304026 D 1245769 CDS LALA0_S07e03356g 34686634 complement(305997..306323) Unknown 1 NW_019212885.1 highly similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS33 306323 34686634 LALA0_S07e03356g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS33 XP_022629364.1 305997 R 1245769 CDS LALA0_S07e03378g 34686635 complement(join(307218..307886,308183..308272)) Unknown 1 NW_019212885.1 highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W (ohnolog of YLR048W) RPS0A Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; 40S ribosomal protein uS2 308272 34686635 LALA0_S07e03378g Lachancea lanzarotensis 40S ribosomal protein uS2 XP_022629365.1 307218 R 1245769 CDS LALA0_S07e03400g 34686636 309960..311996 Unknown 1 NW_019212885.1 similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C FRE8 Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; uncharacterized protein 311996 34686636 LALA0_S07e03400g Lachancea lanzarotensis uncharacterized protein XP_022629366.1 309960 D 1245769 CDS LALA0_S07e03422g 34686637 complement(312064..314475) Unknown 1 NW_019212885.1 similar to uniprot|C5DDM7 Lachancea thermotolerans KLTH0C02266g hypothetical protein; uncharacterized protein 314475 34686637 LALA0_S07e03422g Lachancea lanzarotensis uncharacterized protein XP_022629367.1 312064 R 1245769 CDS LALA0_S07e03444g 34686638 complement(314654..316042) Unknown 1 NW_019212885.1 similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin; N-acetyltransferase 316042 34686638 LALA0_S07e03444g Lachancea lanzarotensis N-acetyltransferase XP_022629368.1 314654 R 1245769 CDS LALA0_S07e03466g 34686639 complement(316746..318194) Unknown 1 NW_019212885.1 highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); zinc finger-containing protein ZPR1 318194 34686639 LALA0_S07e03466g Lachancea lanzarotensis zinc finger-containing protein ZPR1 XP_022629369.1 316746 R 1245769 CDS LALA0_S07e03510g 34686641 319462..320229 Unknown 1 NW_019212885.1 weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p; uncharacterized protein 320229 34686641 LALA0_S07e03510g Lachancea lanzarotensis uncharacterized protein XP_022629370.1 319462 D 1245769 CDS LALA0_S07e03532g 34686642 320371..322215 Unknown 1 NW_019212885.1 similar to uniprot|C5DDN4 Lachancea thermotolerans KLTH0C02420g hypothetical protein; uncharacterized protein 322215 34686642 LALA0_S07e03532g Lachancea lanzarotensis uncharacterized protein XP_022629371.1 320371 D 1245769 CDS LALA0_S07e03554g 34686643 322516..323313 Unknown 1 NW_019212885.1 similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W AIM27 Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; uncharacterized protein 323313 34686643 LALA0_S07e03554g Lachancea lanzarotensis uncharacterized protein XP_022629372.1 322516 D 1245769 CDS LALA0_S07e03576g 34686644 323592..324755 Unknown 1 NW_019212885.1 highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex; GTPase NPA3 324755 34686644 LALA0_S07e03576g Lachancea lanzarotensis GTPase NPA3 XP_022629373.1 323592 D 1245769 CDS LALA0_S07e03598g 34686645 complement(324789..325607) Unknown 1 NW_019212885.1 similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C ADD66 Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly; uncharacterized protein 325607 34686645 LALA0_S07e03598g Lachancea lanzarotensis uncharacterized protein XP_022629374.1 324789 R 1245769 CDS LALA0_S07e03620g 34686646 327389..328357 Unknown 1 NW_019212885.1 highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; deoxyhypusine monooxygenase 328357 34686646 LALA0_S07e03620g Lachancea lanzarotensis deoxyhypusine monooxygenase XP_022629375.1 327389 D 1245769 CDS LALA0_S07e03642g 34686647 328608..329204 Unknown 1 NW_019212885.1 similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; nucleoside triphosphate pyrophosphohydrolase HAM1 329204 34686647 LALA0_S07e03642g Lachancea lanzarotensis nucleoside triphosphate pyrophosphohydrolase HAM1 XP_022629376.1 328608 D 1245769 CDS LALA0_S07e03664g 34686648 329999..333160 Unknown 1 NW_019212885.1 similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; Ran GTPase-binding protein LOS1 333160 34686648 LALA0_S07e03664g Lachancea lanzarotensis Ran GTPase-binding protein LOS1 XP_022629377.1 329999 D 1245769 CDS LALA0_S07e03686g 34686649 334093..335760 Unknown 1 NW_019212885.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 335760 34686649 LALA0_S07e03686g Lachancea lanzarotensis uncharacterized protein XP_022629378.1 334093 D 1245769 CDS LALA0_S07e03708g 34686650 complement(335890..336960) Unknown 1 NW_019212885.1 similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 2 336960 34686650 LALA0_S07e03708g Lachancea lanzarotensis replication factor C subunit 2 XP_022629379.1 335890 R 1245769 CDS LALA0_S07e03730g 34686651 338269..338709 Unknown 1 NW_019212885.1 similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions; uncharacterized protein 338709 34686651 LALA0_S07e03730g Lachancea lanzarotensis uncharacterized protein XP_022629380.1 338269 D 1245769 CDS LALA0_S07e03752g 34686652 complement(338739..346127) Unknown 1 NW_019212885.1 highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C (ohnolog of YJR066W) TOR2 PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; phosphatidylinositol kinase-related protein kinase TOR1 346127 34686652 LALA0_S07e03752g Lachancea lanzarotensis phosphatidylinositol kinase-related protein kinase TOR1 XP_022629381.1 338739 R 1245769 CDS LALA0_S07e03774g 34686653 347046..348401 Unknown 1 NW_019212885.1 highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; actin-related protein 3 348401 34686653 LALA0_S07e03774g Lachancea lanzarotensis actin-related protein 3 XP_022629382.1 347046 D 1245769 CDS LALA0_S07e03796g 34686654 complement(348528..350210) Unknown 1 NW_019212885.1 highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT5 350210 34686654 LALA0_S07e03796g Lachancea lanzarotensis chaperonin-containing T-complex subunit CCT5 XP_022629383.1 348528 R 1245769 CDS LALA0_S07e03818g 34686655 complement(350783..351160) Unknown 1 NW_019212885.1 highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; DNA-directed RNA polymerase I core subunit RPA12 351160 34686655 LALA0_S07e03818g Lachancea lanzarotensis DNA-directed RNA polymerase I core subunit RPA12 XP_022629384.1 350783 R 1245769 CDS LALA0_S07e03840g 34686656 353054..356065 Unknown 1 NW_019212885.1 weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C (ohnolog of YJR061W) MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; uncharacterized protein 356065 34686656 LALA0_S07e03840g Lachancea lanzarotensis uncharacterized protein XP_022629385.1 353054 D 1245769 CDS LALA0_S07e03862g 34686657 356606..357871 Unknown 1 NW_019212885.1 similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; amidase 357871 34686657 LALA0_S07e03862g Lachancea lanzarotensis amidase XP_022629386.1 356606 D 1245769 CDS LALA0_S07e03884g 34686658 complement(357995..360775) Unknown 1 NW_019212885.1 weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C (ohnolog of YJR061W) MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; uncharacterized protein 360775 34686658 LALA0_S07e03884g Lachancea lanzarotensis uncharacterized protein XP_022629387.1 357995 R 1245769 CDS LALA0_S07e03906g 34686659 complement(362291..363244) Unknown 1 NW_019212885.1 weakly similar to uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; uncharacterized protein 363244 34686659 LALA0_S07e03906g Lachancea lanzarotensis uncharacterized protein XP_022629388.1 362291 R 1245769 CDS LALA0_S07e03928g 34686660 complement(366836..369346) Unknown 1 NW_019212885.1 putative transposase of the Rover hAT-like DNA transposon 369346 34686660 LALA0_S07e03928g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022629389.1 366836 R 1245769 CDS LALA0_S07e03950g 34686661 complement(370390..372603) Unknown 1 NW_019212885.1 weakly similar to uniprot|P36002 Saccharomyces cerevisiae YKL198C (ohnolog of YJR059W) PTK1 Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; protein kinase PTK2 372603 34686661 LALA0_S07e03950g Lachancea lanzarotensis protein kinase PTK2 XP_022629390.1 370390 R 1245769 CDS LALA0_S07e03972g 34686662 complement(373091..376189) Unknown 1 NW_019212885.1 similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; AAA family ATPase peroxin 1 376189 34686662 LALA0_S07e03972g Lachancea lanzarotensis AAA family ATPase peroxin 1 XP_022629391.1 373091 R 1245769 CDS LALA0_S07e03994g 34686663 376382..376825 Unknown 1 NW_019212885.1 highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex; uncharacterized protein 376825 34686663 LALA0_S07e03994g Lachancea lanzarotensis uncharacterized protein XP_022629392.1 376382 D 1245769 CDS LALA0_S07e04016g 34686664 complement(376822..377466) Unknown 1 NW_019212885.1 similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p; bifunctional thymidylate/uridylate kinase 377466 34686664 LALA0_S07e04016g Lachancea lanzarotensis bifunctional thymidylate/uridylate kinase XP_022629393.1 376822 R 1245769 CDS LALA0_S07e04060g 34686666 complement(377956..378456) Unknown 1 NW_019212885.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 378456 34686666 LALA0_S07e04060g Lachancea lanzarotensis uncharacterized protein XP_022629394.1 377956 R 1245769 CDS LALA0_S07e04082g 34686667 379184..379699 Unknown 1 NW_019212885.1 weakly similar to uniprot|P47115 Saccharomyces cerevisiae YJR056C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 379699 34686667 LALA0_S07e04082g Lachancea lanzarotensis uncharacterized protein XP_022629395.1 379184 D 1245769 CDS LALA0_S07e04104g 34686668 381659..382561 Unknown 1 NW_019212885.1 similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants; uncharacterized protein 382561 34686668 LALA0_S07e04104g Lachancea lanzarotensis uncharacterized protein XP_022629396.1 381659 D 1245769 CDS LALA0_S07e04126g 34686669 383733..385010 Unknown 1 NW_019212885.1 similar to uniprot|P04387 Saccharomyces cerevisiae YML051W GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding; transcription regulator GAL80 385010 34686669 LALA0_S07e04126g Lachancea lanzarotensis transcription regulator GAL80 XP_022629397.1 383733 D 1245769 CDS LALA0_S07e04148g 34686670 complement(385046..385507) Unknown 1 NW_019212885.1 similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function, required for growth at high temperature; uncharacterized protein 385507 34686670 LALA0_S07e04148g Lachancea lanzarotensis uncharacterized protein XP_022629398.1 385046 R 1245769 CDS LALA0_S07e04170g 34686671 385931..386938 Unknown 1 NW_019212885.1 similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W AIM32 Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; uncharacterized protein 386938 34686671 LALA0_S07e04170g Lachancea lanzarotensis uncharacterized protein XP_022629399.1 385931 D 1245769 CDS LALA0_S07e04192g 34686672 complement(386946..390758) Unknown 1 NW_019212885.1 similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; U2 snRNP complex subunit RSE1 390758 34686672 LALA0_S07e04192g Lachancea lanzarotensis U2 snRNP complex subunit RSE1 XP_022629400.1 386946 R 1245769 CDS LALA0_S07e04214g 34686673 391833..392993 Unknown 1 NW_019212885.1 similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression; uncharacterized protein 392993 34686673 LALA0_S07e04214g Lachancea lanzarotensis uncharacterized protein XP_022629401.1 391833 D 1245769 CDS LALA0_S07e04236g 34686674 complement(393242..393415) Unknown 1 NW_019212885.1 similar to uniprot|P87284 Saccharomyces cerevisiae YDR276C PMP3 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential; uncharacterized protein 393415 34686674 LALA0_S07e04236g Lachancea lanzarotensis uncharacterized protein XP_022629402.1 393242 R 1245769 CDS LALA0_S07e04258g 34686675 394546..397377 Unknown 1 NW_019212885.1 putative transposase of the Rover hAT-like DNA transposon 397377 34686675 LALA0_S07e04258g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022629403.1 394546 D 1245769 CDS LALA0_S07e04302g 34686677 complement(398290..400440) Unknown 1 NW_019212885.1 weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; uncharacterized protein 400440 34686677 LALA0_S07e04302g Lachancea lanzarotensis uncharacterized protein XP_022629404.1 398290 R 1245769 CDS LALA0_S07e04324g 34686678 complement(400978..401658) Unknown 1 NW_019212885.1 highly similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment; uncharacterized protein 401658 34686678 LALA0_S07e04324g Lachancea lanzarotensis uncharacterized protein XP_022629405.1 400978 R 1245769 CDS LALA0_S07e04368g 34686680 complement(402216..404174) Unknown 1 NW_019212885.1 similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; uncharacterized protein 404174 34686680 LALA0_S07e04368g Lachancea lanzarotensis uncharacterized protein XP_022629406.1 402216 R 1245769 CDS LALA0_S07e04390g 34686681 complement(404553..405845) Unknown 1 NW_019212885.1 similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; N,N-dimethylaniline monooxygenase 405845 34686681 LALA0_S07e04390g Lachancea lanzarotensis N,N-dimethylaniline monooxygenase XP_022629407.1 404553 R 1245769 CDS LALA0_S07e04412g 34686682 complement(406954..407382) Unknown 1 NW_019212885.1 similar to uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2 Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; low-affinity Cu transporter 407382 34686682 LALA0_S07e04412g Lachancea lanzarotensis low-affinity Cu transporter XP_022629408.1 406954 R 1245769 CDS LALA0_S07e04434g 34686683 complement(407680..408993) Unknown 1 NW_019212885.1 highly similar to uniprot|P00925 Saccharomyces cerevisiae YHR174W (ohnolog of YGR254W) ENO2 Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose; phosphopyruvate hydratase ENO2 408993 34686683 LALA0_S07e04434g Lachancea lanzarotensis phosphopyruvate hydratase ENO2 XP_022629409.1 407680 R 1245769 CDS LALA0_S07e04456g 34686684 412324..414597 Unknown 1 NW_019212885.1 putative transposase of the Rover hAT-like DNA transposon 414597 34686684 LALA0_S07e04456g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022629410.1 412324 D 1245769 CDS LALA0_S07e04500g 34686686 complement(415439..417853) Unknown 1 NW_019212885.1 similar to uniprot|P38863 Saccharomyces cerevisiae YHR172W SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; uncharacterized protein 417853 34686686 LALA0_S07e04500g Lachancea lanzarotensis uncharacterized protein XP_022629411.1 415439 R 1245769 CDS LALA0_S07e04522g 34686687 419994..421343 Unknown 1 NW_019212885.1 weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1; uncharacterized protein 421343 34686687 LALA0_S07e04522g Lachancea lanzarotensis uncharacterized protein XP_022629412.1 419994 D 1245769 CDS LALA0_S07e04544g 34686688 421842..424439 Unknown 1 NW_019212885.1 weakly similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; uncharacterized protein 424439 34686688 LALA0_S07e04544g Lachancea lanzarotensis uncharacterized protein XP_022629413.1 421842 D 1245769 CDS LALA0_S07e04566g 34686689 424678..425574 Unknown 1 NW_019212885.1 similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1); exosome non-catalytic core subunit CSL4 425574 34686689 LALA0_S07e04566g Lachancea lanzarotensis exosome non-catalytic core subunit CSL4 XP_022629414.1 424678 D 1245769 CDS LALA0_S07e04588g 34686690 complement(425737..426792) Unknown 1 NW_019212885.1 similar to uniprot|P53860 Saccharomyces cerevisiae YNL231C PDR16 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p; phosphatidylinositol transporter 426792 34686690 LALA0_S07e04588g Lachancea lanzarotensis phosphatidylinositol transporter XP_022629415.1 425737 R 1245769 CDS LALA0_S07e04610g 34686691 complement(428026..429771) Unknown 1 NW_019212885.1 similar to uniprot|P53379 Saccharomyces cerevisiae YDR144C (ohnolog of YLR120C) MKC7 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; uncharacterized protein 429771 34686691 LALA0_S07e04610g Lachancea lanzarotensis uncharacterized protein XP_022629416.1 428026 R 1245769 CDS LALA0_S07e04632g 34686692 complement(431224..432324) Unknown 1 NW_019212885.1 similar to uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex; elongin A 432324 34686692 LALA0_S07e04632g Lachancea lanzarotensis elongin A XP_022629417.1 431224 R 1245769 CDS LALA0_S07e04654g 34686693 complement(432792..433946) Unknown 1 NW_019212885.1 similar to uniprot|P23202 Saccharomyces cerevisiae YNL229C URE2 Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion; glutathione peroxidase 433946 34686693 LALA0_S07e04654g Lachancea lanzarotensis glutathione peroxidase XP_022629418.1 432792 R 1245769 CDS LALA0_S07e04676g 34686694 complement(434283..436034) Unknown 1 NW_019212885.1 similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis; uncharacterized protein 436034 34686694 LALA0_S07e04676g Lachancea lanzarotensis uncharacterized protein XP_022629419.1 434283 R 1245769 CDS LALA0_S07e04698g 34686695 complement(436177..439035) Unknown 1 NW_019212885.1 similar to uniprot|C5DB75 Lachancea thermotolerans KLTH0A00110g hypothetical protein; uncharacterized protein 439035 34686695 LALA0_S07e04698g Lachancea lanzarotensis uncharacterized protein XP_022629420.1 436177 R 1245769 CDS LALA0_S07e04720g 34686696 complement(439431..441656) Unknown 1 NW_019212885.1 similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C SQS1 Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; uncharacterized protein 441656 34686696 LALA0_S07e04720g Lachancea lanzarotensis uncharacterized protein XP_022629421.1 439431 R 1245769 CDS LALA0_S07e04742g 34686697 complement(442856..444604) Unknown 1 NW_019212885.1 similar to uniprot|Q08485 Saccharomyces cerevisiae YOR071C NRT1 High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity; uncharacterized protein 444604 34686697 LALA0_S07e04742g Lachancea lanzarotensis uncharacterized protein XP_022629422.1 442856 R 1245769 CDS LALA0_S07e04764g 34686698 445982..447403 Unknown 1 NW_019212885.1 similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; cysteine protease ATG4 447403 34686698 LALA0_S07e04764g Lachancea lanzarotensis cysteine protease ATG4 XP_022629423.1 445982 D 1245769 CDS LALA0_S07e04786g 34686699 449021..449641 Unknown 1 NW_019212885.1 highly similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo; RNA polymerase II subunit A C-terminal domain phosphatase 449641 34686699 LALA0_S07e04786g Lachancea lanzarotensis RNA polymerase II subunit A C-terminal domain phosphatase XP_022629424.1 449021 D 1245769 CDS LALA0_S07e04808g 34686700 complement(449696..451108) Unknown 1 NW_019212885.1 similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures; guanine deaminase 451108 34686700 LALA0_S07e04808g Lachancea lanzarotensis guanine deaminase XP_022629425.1 449696 R 1245769 CDS LALA0_S07e04830g 34686701 452979..454283 Unknown 1 NW_019212885.1 similar to uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated; dihydrolipoyl transsuccinylase 454283 34686701 LALA0_S07e04830g Lachancea lanzarotensis dihydrolipoyl transsuccinylase XP_022629426.1 452979 D 1245769 CDS LALA0_S07e04852g 34686702 complement(454651..456288) Unknown 1 NW_019212885.1 similar to uniprot|Q03764 Saccharomyces cerevisiae YDR147W (ohnolog of YLR133W) EKI1 Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; bifunctional choline kinase/ethanolamine kinase EKI1 456288 34686702 LALA0_S07e04852g Lachancea lanzarotensis bifunctional choline kinase/ethanolamine kinase EKI1 XP_022629427.1 454651 R 1245769 CDS LALA0_S07e04874g 34686703 456648..457568 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus; phosphoric diester hydrolase 457568 34686703 LALA0_S07e04874g Lachancea lanzarotensis phosphoric diester hydrolase XP_022629428.1 456648 D 1245769 CDS LALA0_S07e04896g 34686704 458341..460722 Unknown 1 NW_019212885.1 weakly similar to uniprot|P08153 Saccharomyces cerevisiae YDR146C (ohnolog of YLR131C) SWI5 Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; uncharacterized protein 460722 34686704 LALA0_S07e04896g Lachancea lanzarotensis uncharacterized protein XP_022629429.1 458341 D 1245769 CDS LALA0_S07e04918g 34686705 complement(460813..463626) Unknown 1 NW_019212885.1 highly similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex; snoRNA-binding rRNA-processing protein DIP2 463626 34686705 LALA0_S07e04918g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein DIP2 XP_022629430.1 460813 R 1245769 CDS LALA0_S07e04940g 34686706 complement(463898..465433) Unknown 1 NW_019212885.1 similar to uniprot|Q03761 Saccharomyces cerevisiae YDR145W TAF12 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; uncharacterized protein 465433 34686706 LALA0_S07e04940g Lachancea lanzarotensis uncharacterized protein XP_022629431.1 463898 R 1245769 CDS LALA0_S07e04962g 34686707 complement(join(465768..466550,466634..466636)) Unknown 1 NW_019212885.1 similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation; NEDD8 ligase DCN1 466636 34686707 LALA0_S07e04962g Lachancea lanzarotensis NEDD8 ligase DCN1 XP_022629432.1 465768 R 1245769 CDS LALA0_S07e04984g 34686708 466819..469170 Unknown 1 NW_019212885.1 similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C APC2 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p; anaphase promoting complex subunit 2 469170 34686708 LALA0_S07e04984g Lachancea lanzarotensis anaphase promoting complex subunit 2 XP_022629433.1 466819 D 1245769 CDS LALA0_S07e05006g 34686709 469757..471514 Unknown 1 NW_019212885.1 weakly similar to uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; ubiquitin-protein ligase SAN1 471514 34686709 LALA0_S07e05006g Lachancea lanzarotensis ubiquitin-protein ligase SAN1 XP_022629434.1 469757 D 1245769 CDS LALA0_S07e05028g 34686710 471813..472919 Unknown 1 NW_019212885.1 similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP); uncharacterized protein 472919 34686710 LALA0_S07e05028g Lachancea lanzarotensis uncharacterized protein XP_022629435.1 471813 D 1245769 CDS LALA0_S07e05050g 34686711 complement(472928..473458) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus; uncharacterized protein 473458 34686711 LALA0_S07e05050g Lachancea lanzarotensis uncharacterized protein XP_022629436.1 472928 R 1245769 CDS LALA0_S07e05072g 34686712 473602..474294 Unknown 1 NW_019212885.1 similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; palmitoyl-(protein) hydrolase 474294 34686712 LALA0_S07e05072g Lachancea lanzarotensis palmitoyl-(protein) hydrolase XP_022629437.1 473602 D 1245769 CDS LALA0_S07e05094g 34686713 474677..479719 Unknown 1 NW_019212885.1 similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1 Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 479719 34686713 LALA0_S07e05094g Lachancea lanzarotensis uncharacterized protein XP_022629438.1 474677 D 1245769 CDS LALA0_S07e05116g 34686714 complement(479772..480464) Unknown 1 NW_019212885.1 similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; S-adenosylmethionine-dependent methyltransferase 480464 34686714 LALA0_S07e05116g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022629439.1 479772 R 1245769 CDS LALA0_S07e05138g 34686715 join(480592..480740,480847..480931) Unknown 1 NW_019212885.1 highly similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme); NEDD8 family protein RUB1 480931 34686715 LALA0_S07e05138g Lachancea lanzarotensis NEDD8 family protein RUB1 XP_022629440.1 480592 D 1245769 CDS LALA0_S07e05160g 34686716 481405..483474 Unknown 1 NW_019212885.1 similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins; uncharacterized protein 483474 34686716 LALA0_S07e05160g Lachancea lanzarotensis uncharacterized protein XP_022629441.1 481405 D 1245769 CDS LALA0_S07e05182g 34686717 complement(483533..485278) Unknown 1 NW_019212885.1 similar to uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; mRNA splicing protein MSL5 485278 34686717 LALA0_S07e05182g Lachancea lanzarotensis mRNA splicing protein MSL5 XP_022629442.1 483533 R 1245769 CDS LALA0_S07e05204g 34686718 complement(485394..487853) Unknown 1 NW_019212885.1 similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W CFT2 Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.; cleavage polyadenylation factor subunit CFT2 487853 34686718 LALA0_S07e05204g Lachancea lanzarotensis cleavage polyadenylation factor subunit CFT2 XP_022629443.1 485394 R 1245769 CDS LALA0_S07e05226g 34686719 complement(488713..490902) Unknown 1 NW_019212885.1 weakly similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W HPR1 Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p; uncharacterized protein 490902 34686719 LALA0_S07e05226g Lachancea lanzarotensis uncharacterized protein XP_022629444.1 488713 R 1245769 CDS LALA0_S07e05248g 34686720 491140..493056 Unknown 1 NW_019212885.1 similar to uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; uncharacterized protein 493056 34686720 LALA0_S07e05248g Lachancea lanzarotensis uncharacterized protein XP_022629445.1 491140 D 1245769 CDS LALA0_S07e05270g 34686721 complement(493115..494950) Unknown 1 NW_019212885.1 similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; uncharacterized protein 494950 34686721 LALA0_S07e05270g Lachancea lanzarotensis uncharacterized protein XP_022629446.1 493115 R 1245769 CDS LALA0_S07e05314g 34686723 496478..500983 Unknown 1 NW_019212885.1 highly similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C YCF1 Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR; ATP-binding cassette glutathione S-conjugate transporter YCF1 500983 34686723 LALA0_S07e05314g Lachancea lanzarotensis ATP-binding cassette glutathione S-conjugate transporter YCF1 XP_022629447.1 496478 D 1245769 CDS LALA0_S07e05336g 34686724 complement(501031..502326) Unknown 1 NW_019212885.1 highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; mitogen-activated protein kinase HOG1 502326 34686724 LALA0_S07e05336g Lachancea lanzarotensis mitogen-activated protein kinase HOG1 XP_022629448.1 501031 R 1245769 CDS LALA0_S07e05358g 34686725 506472..506867 Unknown 1 NW_019212885.1 similar to uniprot|Q12127 Saccharomyces cerevisiae YLR110C (ohnolog of YDR133C) CCW12 Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; uncharacterized protein 506867 34686725 LALA0_S07e05358g Lachancea lanzarotensis uncharacterized protein XP_022629449.1 506472 D 1245769 CDS LALA0_S07e05380g 34686726 507693..508994 Unknown 1 NW_019212885.1 similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C (ohnolog of YLR108C) Putative protein of unknown function; uncharacterized protein 508994 34686726 LALA0_S07e05380g Lachancea lanzarotensis uncharacterized protein XP_022629450.1 507693 D 1245769 CDS LALA0_S07e05424g 34686728 509429..510988 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex; uncharacterized protein 510988 34686728 LALA0_S07e05424g Lachancea lanzarotensis uncharacterized protein XP_022629451.1 509429 D 1245769 CDS LALA0_S07e05446g 34686729 511279..512046 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation; uncharacterized protein 512046 34686729 LALA0_S07e05446g Lachancea lanzarotensis uncharacterized protein XP_022629452.1 511279 D 1245769 CDS LALA0_S07e05468g 34686730 complement(512067..513260) Unknown 1 NW_019212885.1 similar to uniprot|Q7LI70 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; RNA exonuclease 513260 34686730 LALA0_S07e05468g Lachancea lanzarotensis RNA exonuclease XP_022629453.1 512067 R 1245769 CDS LALA0_S07e05490g 34686731 513565..528342 Unknown 1 NW_019212885.1 similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus; AAA family ATPase midasin 528342 34686731 LALA0_S07e05490g Lachancea lanzarotensis AAA family ATPase midasin XP_022629454.1 513565 D 1245769 CDS LALA0_S07e05512g 34686732 529801..530862 Unknown 1 NW_019212885.1 similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C SEN2 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; tRNA splicing endonuclease subunit SEN2 530862 34686732 LALA0_S07e05512g Lachancea lanzarotensis tRNA splicing endonuclease subunit SEN2 XP_022629455.1 529801 D 1245769 CDS LALA0_S07e05534g 34686733 complement(530977..531357) Unknown 1 NW_019212885.1 similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W LCL2 Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); uncharacterized protein 531357 34686733 LALA0_S07e05534g Lachancea lanzarotensis uncharacterized protein XP_022629456.1 530977 R 1245769 CDS LALA0_S07e05556g 34686734 531579..533546 Unknown 1 NW_019212885.1 similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes; DNA replication initiation factor CDC45 533546 34686734 LALA0_S07e05556g Lachancea lanzarotensis DNA replication initiation factor CDC45 XP_022629457.1 531579 D 1245769 CDS LALA0_S07e05578g 34686735 533961..534896 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q12107 Saccharomyces cerevisiae YLR102C APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; anaphase promoting complex subunit 9 534896 34686735 LALA0_S07e05578g Lachancea lanzarotensis anaphase promoting complex subunit 9 XP_022629458.1 533961 D 1245769 CDS LALA0_S07e05600g 34686736 join(535103..535123,535235..537145) Unknown 1 NW_019212885.1 highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; fimbrin 537145 34686736 LALA0_S07e05600g Lachancea lanzarotensis fimbrin XP_022629459.1 535103 D 1245769 CDS LALA0_S07e05622g 34686737 complement(join(537222..538218,538281..538324)) Unknown 1 NW_019212885.1 highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase, catalyzes the last of three steps required to remove two C- 4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; 3-keto-steroid reductase 538324 34686737 LALA0_S07e05622g Lachancea lanzarotensis 3-keto-steroid reductase XP_022629460.1 537222 R 1245769 CDS LALA0_S07e05644g 34686738 complement(538527..541838) Unknown 1 NW_019212885.1 similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W MTC5 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13- 1; uncharacterized protein 541838 34686738 LALA0_S07e05644g Lachancea lanzarotensis uncharacterized protein XP_022629461.1 538527 R 1245769 CDS LALA0_S07e05666g 34686739 complement(542204..546928) Unknown 1 NW_019212885.1 highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; pentafunctional protein ARO1p 546928 34686739 LALA0_S07e05666g Lachancea lanzarotensis pentafunctional protein ARO1p XP_022629462.1 542204 R 1245769 CDS LALA0_S07e05688g 34686740 complement(547807..548253) Unknown 1 NW_019212885.1 similar to uniprot|C5DN04 Lachancea thermotolerans KLTH0G13134g hypothetical protein; uncharacterized protein 548253 34686740 LALA0_S07e05688g Lachancea lanzarotensis uncharacterized protein XP_022629463.1 547807 R 1245769 CDS LALA0_S07e05710g 34686741 complement(549416..550393) Unknown 1 NW_019212885.1 similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion; palmitoyltransferase SWF1 550393 34686741 LALA0_S07e05710g Lachancea lanzarotensis palmitoyltransferase SWF1 XP_022629464.1 549416 R 1245769 CDS LALA0_S07e05732g 34686742 550530..551024 Unknown 1 NW_019212885.1 similar to uniprot|C5DN35 Lachancea thermotolerans KLTH0G13816g hypothetical protein; uncharacterized protein 551024 34686742 LALA0_S07e05732g Lachancea lanzarotensis uncharacterized protein XP_022629465.1 550530 D 1245769 CDS LALA0_S07e05754g 34686743 complement(551130..551504) Unknown 1 NW_019212885.1 some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Putative protein of unknown function; uncharacterized protein 551504 34686743 LALA0_S07e05754g Lachancea lanzarotensis uncharacterized protein XP_022629466.1 551130 R 1245769 CDS LALA0_S07e05776g 34686744 551706..552932 Unknown 1 NW_019212885.1 similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C (ohnolog of YLR099C) ECM18 Protein of unknown function, similar to Rlp24p; alpha/beta hydrolase family protein 552932 34686744 LALA0_S07e05776g Lachancea lanzarotensis alpha/beta hydrolase family protein XP_022629467.1 551706 D 1245769 CDS LALA0_S07e05798g 34686745 complement(553694..554734) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q04608 Saccharomyces cerevisiae YDR124W Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor; uncharacterized protein 554734 34686745 LALA0_S07e05798g Lachancea lanzarotensis uncharacterized protein XP_022629468.1 553694 R 1245769 CDS LALA0_S07e05820g 34686746 555061..556119 Unknown 1 NW_019212885.1 similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies; SCF ubiquitin ligase complex subunit HRT3 556119 34686746 LALA0_S07e05820g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit HRT3 XP_022629469.1 555061 D 1245769 CDS LALA0_S07e05842g 34686747 556499..557500 Unknown 1 NW_019212885.1 weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; uncharacterized protein 557500 34686747 LALA0_S07e05842g Lachancea lanzarotensis uncharacterized protein XP_022629470.1 556499 D 1245769 CDS LALA0_S07e05864g 34686748 complement(557702..560935) Unknown 1 NW_019212885.1 similar to uniprot|P13185 Saccharomyces cerevisiae YDR122W (ohnolog of YLR096W) KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p; uncharacterized protein 560935 34686748 LALA0_S07e05864g Lachancea lanzarotensis uncharacterized protein XP_022629471.1 557702 R 1245769 CDS LALA0_S07e05886g 34686749 563634..565637 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif; uncharacterized protein 565637 34686749 LALA0_S07e05886g Lachancea lanzarotensis uncharacterized protein XP_022629472.1 563634 D 1245769 CDS LALA0_S07e05908g 34686750 566220..567572 Unknown 1 NW_019212885.1 weakly similar to uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function; uncharacterized protein 567572 34686750 LALA0_S07e05908g Lachancea lanzarotensis uncharacterized protein XP_022629473.1 566220 D 1245769 CDS LALA0_S07e05930g 34686751 570249..571757 Unknown 1 NW_019212885.1 weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; uncharacterized protein 571757 34686751 LALA0_S07e05930g Lachancea lanzarotensis uncharacterized protein XP_022629474.1 570249 D 1245769 CDS LALA0_S07e05952g 34686752 join(572531..572546,572638..573308) Unknown 1 NW_019212885.1 similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane; uncharacterized protein 573308 34686752 LALA0_S07e05952g Lachancea lanzarotensis uncharacterized protein XP_022629475.1 572531 D 1245769 CDS LALA0_S07e05974g 34686753 complement(573491..574000) Unknown 1 NW_019212885.1 similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing; DNA polymerase epsilon noncatalytic subunit 574000 34686753 LALA0_S07e05974g Lachancea lanzarotensis DNA polymerase epsilon noncatalytic subunit XP_022629476.1 573491 R 1245769 CDS LALA0_S07e05996g 34686754 574651..576309 Unknown 1 NW_019212885.1 similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments; tRNA (guanine26-N2)-dimethyltransferase 576309 34686754 LALA0_S07e05996g Lachancea lanzarotensis tRNA (guanine26-N2)-dimethyltransferase XP_022629477.1 574651 D 1245769 CDS LALA0_S07e06018g 34686755 complement(576489..576734) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); uncharacterized protein 576734 34686755 LALA0_S07e06018g Lachancea lanzarotensis uncharacterized protein XP_022629478.1 576489 R 1245769 CDS LALA0_S07e06040g 34686756 complement(577775..579571) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 579571 34686756 LALA0_S07e06040g Lachancea lanzarotensis uncharacterized protein XP_022629479.1 577775 R 1245769 CDS LALA0_S07e06062g 34686757 complement(580213..582882) Unknown 1 NW_019212885.1 similar to uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; sulfate permease 582882 34686757 LALA0_S07e06062g Lachancea lanzarotensis sulfate permease XP_022629480.1 580213 R 1245769 CDS LALA0_S07e06084g 34686758 complement(583326..585434) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q04601 Saccharomyces cerevisiae YDR118W APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; anaphase promoting complex subunit 4 585434 34686758 LALA0_S07e06084g Lachancea lanzarotensis anaphase promoting complex subunit 4 XP_022629481.1 583326 R 1245769 CDS LALA0_S07e06106g 34686759 585961..587730 Unknown 1 NW_019212885.1 similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C TMA64 Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity; uncharacterized protein 587730 34686759 LALA0_S07e06106g Lachancea lanzarotensis uncharacterized protein XP_022629482.1 585961 D 1245769 CDS LALA0_S07e06128g 34686760 587965..588810 Unknown 1 NW_019212885.1 similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL1m 588810 34686760 LALA0_S07e06128g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL1m XP_022629483.1 587965 D 1245769 CDS LALA0_S07e06150g 34686761 complement(589007..589345) Unknown 1 NW_019212885.1 similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; mitochondrial 54S ribosomal protein bL34m 589345 34686761 LALA0_S07e06150g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL34m XP_022629484.1 589007 R 1245769 CDS LALA0_S07e06172g 34686762 complement(589733..590560) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q12393 Saccharomyces cerevisiae YLR091W GEP5 Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; uncharacterized protein 590560 34686762 LALA0_S07e06172g Lachancea lanzarotensis uncharacterized protein XP_022629485.1 589733 R 1245769 CDS LALA0_S07e06194g 34686763 591157..592143 Unknown 1 NW_019212885.1 weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; securin 592143 34686763 LALA0_S07e06194g Lachancea lanzarotensis securin XP_022629486.1 591157 D 1245769 CDS LALA0_S07e06216g 34686764 complement(592227..593477) Unknown 1 NW_019212885.1 similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 593477 34686764 LALA0_S07e06216g Lachancea lanzarotensis uncharacterized protein XP_022629487.1 592227 R 1245769 CDS LALA0_S07e06238g 34686765 595144..596730 Unknown 1 NW_019212885.1 similar to uniprot|P52892 Saccharomyces cerevisiae YDR111C (ohnolog of YLR089C) ALT2 Putative alanine transaminase (glutamic pyruvic transaminase); alanine transaminase ALT1 596730 34686765 LALA0_S07e06238g Lachancea lanzarotensis alanine transaminase ALT1 XP_022629488.1 595144 D 1245769 CDS LALA0_S07e06260g 34686766 complement(596799..598238) Unknown 1 NW_019212885.1 weakly similar to uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases; replication fork barrier binding protein FOB1 598238 34686766 LALA0_S07e06260g Lachancea lanzarotensis replication fork barrier binding protein FOB1 XP_022629489.1 596799 R 1245769 CDS LALA0_S07e06282g 34686767 complement(598400..600184) Unknown 1 NW_019212885.1 similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER; GPI-anchor transamidase subunit GAA1 600184 34686767 LALA0_S07e06282g Lachancea lanzarotensis GPI-anchor transamidase subunit GAA1 XP_022629490.1 598400 R 1245769 CDS LALA0_S07e06304g 34686768 601186..610041 Unknown 1 NW_019212885.1 similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 610041 34686768 LALA0_S07e06304g Lachancea lanzarotensis uncharacterized protein XP_022629491.1 601186 D 1245769 CDS LALA0_S07e06326g 34686769 complement(610084..614259) Unknown 1 NW_019212885.1 similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate; condensin subunit SMC4 614259 34686769 LALA0_S07e06326g Lachancea lanzarotensis condensin subunit SMC4 XP_022629492.1 610084 R 1245769 CDS LALA0_S07e06348g 34686770 615595..616884 Unknown 1 NW_019212885.1 similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; uncharacterized protein 616884 34686770 LALA0_S07e06348g Lachancea lanzarotensis uncharacterized protein XP_022629493.1 615595 D 1245769 CDS LALA0_S07e06370g 34686771 619883..622033 Unknown 1 NW_019212885.1 similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Putative kinase; uncharacterized protein 622033 34686771 LALA0_S07e06370g Lachancea lanzarotensis uncharacterized protein XP_022629494.1 619883 D 1245769 CDS LALA0_S07e06392g 34686772 623433..625382 Unknown 1 NW_019212885.1 similar to uniprot|C5DN41 Lachancea thermotolerans KLTH0G13970g putative actin-related protein; uncharacterized protein 625382 34686772 LALA0_S07e06392g Lachancea lanzarotensis uncharacterized protein XP_022629495.1 623433 D 1245769 CDS LALA0_S07e06414g 34686773 626726..630373 Unknown 1 NW_019212885.1 similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p; uncharacterized protein 630373 34686773 LALA0_S07e06414g Lachancea lanzarotensis uncharacterized protein XP_022629496.1 626726 D 1245769 CDS LALA0_S07e06436g 34686774 complement(630506..632605) Unknown 1 NW_019212885.1 similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W TRS85 Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role; uncharacterized protein 632605 34686774 LALA0_S07e06436g Lachancea lanzarotensis uncharacterized protein XP_022629497.1 630506 R 1245769 CDS LALA0_S07e06458g 34686775 634111..636177 Unknown 1 NW_019212885.1 similar to uniprot|Q04562 Saccharomyces cerevisiae YDR107C (ohnolog of YLR083C) TMN2 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; uncharacterized protein 636177 34686775 LALA0_S07e06458g Lachancea lanzarotensis uncharacterized protein XP_022629498.1 634111 D 1245769 CDS LALA0_S07e06502g 34686777 636674..636925 Unknown 1 NW_019212885.1 similar to uniprot|Q3E784 Saccharomyces cerevisiae YER180C-A SLO1 Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO; uncharacterized protein 636925 34686777 LALA0_S07e06502g Lachancea lanzarotensis uncharacterized protein XP_022629499.1 636674 D 1245769 CDS LALA0_S07e06524g 34686778 637131..637886 Unknown 1 NW_019212885.1 weakly similar to uniprot|P32645 Saccharomyces cerevisiae YER180C ISC10 Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells; uncharacterized protein 637886 34686778 LALA0_S07e06524g Lachancea lanzarotensis uncharacterized protein XP_022629500.1 637131 D 1245769 CDS LALA0_S07e06546g 34686779 complement(637963..639156) Unknown 1 NW_019212885.1 some similarities with uniprot|C5DN79 Lachancea thermotolerans KLTH0G14828g hypothetical protein; uncharacterized protein 639156 34686779 LALA0_S07e06546g Lachancea lanzarotensis uncharacterized protein XP_022629501.1 637963 R 1245769 CDS LALA0_S07e06568g 34686780 640059..641480 Unknown 1 NW_019212885.1 highly similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance; uncharacterized protein 641480 34686780 LALA0_S07e06568g Lachancea lanzarotensis uncharacterized protein XP_022629502.1 640059 D 1245769 CDS LALA0_S07e06590g 34686781 complement(join(641545..642417,642521..642649)) Unknown 1 NW_019212885.1 highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; recombinase DMC1 642649 34686781 LALA0_S07e06590g Lachancea lanzarotensis recombinase DMC1 XP_022629503.1 641545 R 1245769 CDS LALA0_S07e06612g 34686782 complement(643160..644947) Unknown 1 NW_019212885.1 similar to uniprot|Q03862 Saccharomyces cerevisiae YDR101C ARX1 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex; uncharacterized protein 644947 34686782 LALA0_S07e06612g Lachancea lanzarotensis uncharacterized protein XP_022629504.1 643160 R 1245769 CDS LALA0_S07e06634g 34686783 646121..647350 Unknown 1 NW_019212885.1 highly similar to uniprot|P16387 Saccharomyces cerevisiae YER178W PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha 647350 34686783 LALA0_S07e06634g Lachancea lanzarotensis pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha XP_022629505.1 646121 D 1245769 CDS LALA0_S07e06656g 34686784 648407..651286 Unknown 1 NW_019212885.1 weakly similar to uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p; uncharacterized protein 651286 34686784 LALA0_S07e06656g Lachancea lanzarotensis uncharacterized protein XP_022629506.1 648407 D 1245769 CDS LALA0_S07e06678g 34686785 complement(651325..655311) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; uncharacterized protein 655311 34686785 LALA0_S07e06678g Lachancea lanzarotensis uncharacterized protein XP_022629507.1 651325 R 1245769 CDS LALA0_S07e06700g 34686786 complement(655831..656250) Unknown 1 NW_019212885.1 similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; uncharacterized protein 656250 34686786 LALA0_S07e06700g Lachancea lanzarotensis uncharacterized protein XP_022629508.1 655831 R 1245769 CDS LALA0_S07e06722g 34686787 complement(657125..657886) Unknown 1 NW_019212885.1 highly similar to uniprot|P29311 Saccharomyces cerevisiae YER177W (ohnolog of YDR099W) BMH1 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; uncharacterized protein 657886 34686787 LALA0_S07e06722g Lachancea lanzarotensis uncharacterized protein XP_022629509.1 657125 R 1245769 CDS LALA0_S07e06766g 34686789 complement(659714..662407) Unknown 1 NW_019212885.1 similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes; RNA helicase 662407 34686789 LALA0_S07e06766g Lachancea lanzarotensis RNA helicase XP_022629510.1 659714 R 1245769 CDS LALA0_S07e06788g 34686790 663164..664030 Unknown 1 NW_019212885.1 similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; trans-aconitate 3-methyltransferase 664030 34686790 LALA0_S07e06788g Lachancea lanzarotensis trans-aconitate 3-methyltransferase XP_022629511.1 663164 D 1245769 CDS LALA0_S07e06810g 34686791 664432..665202 Unknown 1 NW_019212885.1 similar to uniprot|P32642 Saccharomyces cerevisiae YER174C (ohnolog of YDR098C) GRX4 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; uncharacterized protein 665202 34686791 LALA0_S07e06810g Lachancea lanzarotensis uncharacterized protein XP_022629512.1 664432 D 1245769 CDS LALA0_S07e06832g 34686792 complement(665333..667258) Unknown 1 NW_019212885.1 similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein; uncharacterized protein 667258 34686792 LALA0_S07e06832g Lachancea lanzarotensis uncharacterized protein XP_022629513.1 665333 R 1245769 CDS LALA0_S07e06854g 34686793 667651..674211 Unknown 1 NW_019212885.1 similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD; ATP-dependent RNA helicase BRR2 674211 34686793 LALA0_S07e06854g Lachancea lanzarotensis ATP-dependent RNA helicase BRR2 XP_022629514.1 667651 D 1245769 CDS LALA0_S07e06876g 34686794 complement(674311..676641) Unknown 1 NW_019212885.1 highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 676641 34686794 LALA0_S07e06876g Lachancea lanzarotensis TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 XP_022629515.1 674311 R 1245769 CDS LALA0_S07e06898g 34686795 complement(676995..677669) Unknown 1 NW_019212885.1 similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background; adenylate kinase ADK2 677669 34686795 LALA0_S07e06898g Lachancea lanzarotensis adenylate kinase ADK2 XP_022629516.1 676995 R 1245769 CDS LALA0_S07e06920g 34686796 679481..681298 Unknown 1 NW_019212885.1 highly similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; polyadenylate-binding protein 681298 34686796 LALA0_S07e06920g Lachancea lanzarotensis polyadenylate-binding protein XP_022629517.1 679481 D 1245769 CDS LALA0_S07e06942g 34686797 join(681492..681743,681820..682245) Unknown 1 NW_019212885.1 some similarities with uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus; E2 ubiquitin-conjugating protein UBC13 682245 34686797 LALA0_S07e06942g Lachancea lanzarotensis E2 ubiquitin-conjugating protein UBC13 XP_022629518.1 681492 D 1245769 CDS LALA0_S07e06964g 34686798 683272..688062 Unknown 1 NW_019212885.1 similar to uniprot|P32660 Saccharomyces cerevisiae YER166W (ohnolog of YDR093W) DNF1 Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; aminophospholipid-translocating P4-type ATPase DNF1 688062 34686798 LALA0_S07e06964g Lachancea lanzarotensis aminophospholipid-translocating P4-type ATPase DNF1 XP_022629519.1 683272 D 1245769 CDS LALA0_S07e06986g 34686799 689943..691976 Unknown 1 NW_019212885.1 weakly similar to uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations; uncharacterized protein 691976 34686799 LALA0_S07e06986g Lachancea lanzarotensis uncharacterized protein XP_022629520.1 689943 D 1245769 CDS LALA0_S07e07008g 34686800 complement(692174..693733) Unknown 1 NW_019212885.1 similar to uniprot|P21269 Saccharomyces cerevisiae YER168C CCA1 ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; tRNA adenylyltransferase 693733 34686800 LALA0_S07e07008g Lachancea lanzarotensis tRNA adenylyltransferase XP_022629521.1 692174 R 1245769 CDS LALA0_S07e07030g 34686801 694930..697449 Unknown 1 NW_019212885.1 similar to uniprot|P39956 Saccharomyces cerevisiae YER169W (ohnolog of YDR096W) RPH1 JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri-and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; uncharacterized protein 697449 34686801 LALA0_S07e07030g Lachancea lanzarotensis uncharacterized protein XP_022629522.1 694930 D 1245769 CDS LALA0_S07e07052g 34686802 complement(697596..701384) Unknown 1 NW_019212885.1 similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p; mismatch repair ATPase MSH6 701384 34686802 LALA0_S07e07052g Lachancea lanzarotensis mismatch repair ATPase MSH6 XP_022629523.1 697596 R 1245769 CDS LALA0_S07e07074g 34686803 complement(702242..706579) Unknown 1 NW_019212885.1 similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes; chromatin-remodeling ATPase CHD1 706579 34686803 LALA0_S07e07074g Lachancea lanzarotensis chromatin-remodeling ATPase CHD1 XP_022629524.1 702242 R 1245769 CDS LALA0_S07e07096g 34686804 708834..710660 Unknown 1 NW_019212885.1 highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; Fe-S cluster-binding ribosome biosynthesis protein 710660 34686804 LALA0_S07e07096g Lachancea lanzarotensis Fe-S cluster-binding ribosome biosynthesis protein XP_022629525.1 708834 D 1245769 CDS LALA0_S07e07118g 34686805 711406..712197 Unknown 1 NW_019212885.1 similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Putative protein of unknown function; uncharacterized protein 712197 34686805 LALA0_S07e07118g Lachancea lanzarotensis uncharacterized protein XP_022629526.1 711406 D 1245769 CDS LALA0_S07e07140g 34686806 712412..714850 Unknown 1 NW_019212885.1 similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; uncharacterized protein 714850 34686806 LALA0_S07e07140g Lachancea lanzarotensis uncharacterized protein XP_022629527.1 712412 D 1245769 CDS LALA0_S07e07162g 34686807 715125..716099 Unknown 1 NW_019212885.1 similar to uniprot|P06843 Saccharomyces cerevisiae YER161C SPT2 Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins; uncharacterized protein 716099 34686807 LALA0_S07e07162g Lachancea lanzarotensis uncharacterized protein XP_022629528.1 715125 D 1245769 CDS LALA0_S07e07184g 34686808 complement(716156..718594) Unknown 1 NW_019212885.1 similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Protein of unknown function; deletion confers resistance to Nickel; uncharacterized protein 718594 34686808 LALA0_S07e07184g Lachancea lanzarotensis uncharacterized protein XP_022629529.1 716156 R 1245769 CDS LALA0_S07e07206g 34686809 720471..721493 Unknown 1 NW_019212885.1 similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain; mRNA splicing protein SLU7 721493 34686809 LALA0_S07e07206g Lachancea lanzarotensis mRNA splicing protein SLU7 XP_022629530.1 720471 D 1245769 CDS LALA0_S07e07228g 34686810 721929..722792 Unknown 1 NW_019212885.1 similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles; uncharacterized protein 722792 34686810 LALA0_S07e07228g Lachancea lanzarotensis uncharacterized protein XP_022629531.1 721929 D 1245769 CDS LALA0_S07e07250g 34686811 723049..723261 Unknown 1 NW_019212885.1 similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; translocon subunit SSS1 723261 34686811 LALA0_S07e07250g Lachancea lanzarotensis translocon subunit SSS1 XP_022629532.1 723049 D 1245769 CDS LALA0_S07e07272g 34686812 724007..724378 Unknown 1 NW_019212885.1 similar to uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; negative cofactor 2 transcription regulator complex subunit BUR6 724378 34686812 LALA0_S07e07272g Lachancea lanzarotensis negative cofactor 2 transcription regulator complex subunit BUR6 XP_022629533.1 724007 D 1245769 CDS LALA0_S07e07294g 34686813 725268..726854 Unknown 1 NW_019212885.1 weakly similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; uncharacterized protein 726854 34686813 LALA0_S07e07294g Lachancea lanzarotensis uncharacterized protein XP_022629534.1 725268 D 1245769 CDS LALA0_S07e07316g 34686814 727480..729474 Unknown 1 NW_019212885.1 weakly similar to uniprot|P40095 Saccharomyces cerevisiae YER158C (ohnolog of YDR085C) Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p; uncharacterized protein 729474 34686814 LALA0_S07e07316g Lachancea lanzarotensis uncharacterized protein XP_022629535.1 727480 D 1245769 CDS LALA0_S07e07338g 34686815 729889..730476 Unknown 1 NW_019212885.1 similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 730476 34686815 LALA0_S07e07338g Lachancea lanzarotensis uncharacterized protein XP_022629536.1 729889 D 1245769 CDS LALA0_S07e07360g 34686816 complement(730616..731830) Unknown 1 NW_019212885.1 similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8 Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation; 25S rRNA (adenine645-N1)-methyltransferase 731830 34686816 LALA0_S07e07360g Lachancea lanzarotensis 25S rRNA (adenine645-N1)-methyltransferase XP_022629537.1 730616 R 1245769 CDS LALA0_S07e07382g 34686817 732871..732972 Unknown 1 NW_019212885.1 similar to uniprot|P34166 Saccharomyces cerevisiae YNL145W MFA2 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1; mating pheromone a 732972 34686817 LALA0_S07e07382g Lachancea lanzarotensis mating pheromone a XP_022629538.1 732871 D 1245769 CDS LALA0_S07e07404g 34686818 733834..734172 Unknown 1 NW_019212885.1 similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit h 734172 34686818 LALA0_S07e07404g Lachancea lanzarotensis F1F0 ATP synthase subunit h XP_022629539.1 733834 D 1245769 CDS LALA0_S07e07426g 34686819 734595..735350 Unknown 1 NW_019212885.1 similar to uniprot|C5DM03 Lachancea thermotolerans KLTH0G04906g hypothetical protein; uncharacterized protein 735350 34686819 LALA0_S07e07426g Lachancea lanzarotensis uncharacterized protein XP_022629540.1 734595 D 1245769 CDS LALA0_S07e07448g 34686820 736086..736730 Unknown 1 NW_019212885.1 highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C (ohnolog of YLR293C) GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; Ran GTPase GSP1 736730 34686820 LALA0_S07e07448g Lachancea lanzarotensis Ran GTPase GSP1 XP_022629541.1 736086 D 1245769 CDS LALA0_S07e07470g 34686821 737324..737914 Unknown 1 NW_019212885.1 similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; Sec63 complex subunit SEC72 737914 34686821 LALA0_S07e07470g Lachancea lanzarotensis Sec63 complex subunit SEC72 XP_022629542.1 737324 D 1245769 CDS LALA0_S07e07492g 34686822 738316..739464 Unknown 1 NW_019212885.1 similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B subunit beta 739464 34686822 LALA0_S07e07492g Lachancea lanzarotensis translation initiation factor eIF2B subunit beta XP_022629543.1 738316 D 1245769 CDS LALA0_S07e07514g 34686823 740082..740900 Unknown 1 NW_019212885.1 similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene; ubiquinone biosynthesis protein COQ11 740900 34686823 LALA0_S07e07514g Lachancea lanzarotensis ubiquinone biosynthesis protein COQ11 XP_022629544.1 740082 D 1245769 CDS LALA0_S07e07536g 34686824 complement(740984..742906) Unknown 1 NW_019212885.1 highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor; GTPase GUF1 742906 34686824 LALA0_S07e07536g Lachancea lanzarotensis GTPase GUF1 XP_022629545.1 740984 R 1245769 CDS LALA0_S07e07558g 34686825 743820..745112 Unknown 1 NW_019212885.1 similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1; uncharacterized protein 745112 34686825 LALA0_S07e07558g Lachancea lanzarotensis uncharacterized protein XP_022629546.1 743820 D 1245769 CDS LALA0_S07e07580g 34686826 complement(745339..746523) Unknown 1 NW_019212885.1 highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; O-phospho-L-serine:2-oxoglutarate transaminase 746523 34686826 LALA0_S07e07580g Lachancea lanzarotensis O-phospho-L-serine:2-oxoglutarate transaminase XP_022629547.1 745339 R 1245769 CDS LALA0_S07e07602g 34686827 join(748032..748034,748395..748580) Unknown 1 NW_019212885.1 highly similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C (ohnolog of YLR287C-A) RPS30B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein; 40S ribosomal protein eS30 748580 34686827 LALA0_S07e07602g Lachancea lanzarotensis 40S ribosomal protein eS30 XP_022629548.1 748032 D 1245769 CDS LALA0_S07e07624g 34686828 748878..749939 Unknown 1 NW_019212885.1 similar to uniprot|Q05881 Saccharomyces cerevisiae YLR287C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene; uncharacterized protein 749939 34686828 LALA0_S07e07624g Lachancea lanzarotensis uncharacterized protein XP_022629549.1 748878 D 1245769 CDS LALA0_S07e07646g 34686829 complement(750029..750346) Unknown 1 NW_019212885.1 highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES; uncharacterized protein 750346 34686829 LALA0_S07e07646g Lachancea lanzarotensis uncharacterized protein XP_022629550.1 750029 R 1245769 CDS LALA0_S07e07668g 34686830 complement(751162..753195) Unknown 1 NW_019212885.1 similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP); actin-binding protein LAS17 753195 34686830 LALA0_S07e07668g Lachancea lanzarotensis actin-binding protein LAS17 XP_022629551.1 751162 R 1245769 CDS LALA0_S07e07690g 34686831 complement(754184..756502) Unknown 1 NW_019212885.1 weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W IRC8 Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc; uncharacterized protein 756502 34686831 LALA0_S07e07690g Lachancea lanzarotensis uncharacterized protein XP_022629552.1 754184 R 1245769 CDS LALA0_S07e07712g 34686832 complement(757172..758110) Unknown 1 NW_019212885.1 similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; retromer subunit PEP8 758110 34686832 LALA0_S07e07712g Lachancea lanzarotensis retromer subunit PEP8 XP_022629553.1 757172 R 1245769 CDS LALA0_S07e07734g 34686833 complement(758704..760098) Unknown 1 NW_019212885.1 similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; uncharacterized protein 760098 34686833 LALA0_S07e07734g Lachancea lanzarotensis uncharacterized protein XP_022629554.1 758704 R 1245769 CDS LALA0_S07e07756g 34686834 complement(760704..762185) Unknown 1 NW_019212885.1 weakly similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; uncharacterized protein 762185 34686834 LALA0_S07e07756g Lachancea lanzarotensis uncharacterized protein XP_022629555.1 760704 R 1245769 CDS LALA0_S07e07778g 34686835 complement(764844..765563) Unknown 1 NW_019212885.1 similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU; uncharacterized protein 765563 34686835 LALA0_S07e07778g Lachancea lanzarotensis uncharacterized protein XP_022629556.1 764844 R 1245769 CDS LALA0_S08e00100g 34686836 complement(1..345) Unknown 1 NW_019212886.1 some similarities with uniprot|Q2US70 Aspergillus oryzae AOR_1_960174 hypothetical protein; 345 34686836 LALA0_S08e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S08e00122g 34686837 join(2397..2534,2534..2863) Unknown 1 NW_019212886.1 similar to uniprot|Q2US70 Aspergillus oryzae AOR_1_960174 hypothetical protein; 2863 34686837 LALA0_S08e00122g Lachancea lanzarotensis 2397 D 1245769 CDS LALA0_S08e00144g 34686838 complement(3783..4778) Unknown 1 NW_019212886.1 similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; uncharacterized protein 4778 34686838 LALA0_S08e00144g Lachancea lanzarotensis uncharacterized protein XP_022629557.1 3783 R 1245769 CDS LALA0_S08e00166g 34686839 complement(5354..6679) Unknown 1 NW_019212886.1 some similarities with uniprot|P40896 Saccharomyces cerevisiae YJL213W Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p; uncharacterized protein 6679 34686839 LALA0_S08e00166g Lachancea lanzarotensis uncharacterized protein XP_022629558.1 5354 R 1245769 CDS LALA0_S08e00188g 34686840 7390..8865 Unknown 1 NW_019212886.1 weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 8865 34686840 LALA0_S08e00188g Lachancea lanzarotensis uncharacterized protein XP_022629559.1 7390 D 1245769 CDS LALA0_S08e00210g 34686841 9669..10121 Unknown 1 NW_019212886.1 hypothetical protein; uncharacterized protein 10121 34686841 LALA0_S08e00210g Lachancea lanzarotensis uncharacterized protein XP_022629560.1 9669 D 1245769 CDS LALA0_S08e00232g 34686842 complement(11847..13913) Unknown 1 NW_019212886.1 similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase 13913 34686842 LALA0_S08e00232g Lachancea lanzarotensis bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase XP_022629561.1 11847 R 1245769 CDS LALA0_S08e00254g 34686843 join(14211..14849,14854..15147) Unknown 1 NW_019212886.1 some similarities with uniprot|P13045 Saccharomyces cerevisiae YDR009W (ohnolog of YBR020W) GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; 15147 34686843 LALA0_S08e00254g Lachancea lanzarotensis 14211 D 1245769 CDS LALA0_S08e00276g 34686844 complement(15594..16694) Unknown 1 NW_019212886.1 highly similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; UDP-glucose:hexose-1-phosphate uridylyltransferase 16694 34686844 LALA0_S08e00276g Lachancea lanzarotensis UDP-glucose:hexose-1-phosphate uridylyltransferase XP_022629562.1 15594 R 1245769 CDS LALA0_S08e00298g 34686845 18668..20026 Unknown 1 NW_019212886.1 some similarities with uniprot|G2QVF1 Thielavia terrestris THITE_2040324 hypothetical protein; uncharacterized protein 20026 34686845 LALA0_S08e00298g Lachancea lanzarotensis uncharacterized protein XP_022629563.1 18668 D 1245769 CDS LALA0_S08e00320g 34686846 complement(22493..23125) Unknown 1 NW_019212886.1 similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W VEL1 Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; uncharacterized protein 23125 34686846 LALA0_S08e00320g Lachancea lanzarotensis uncharacterized protein XP_022629564.1 22493 R 1245769 CDS LALA0_S08e00342g 34686847 complement(join(24237..24923,24923..25153,25153..25191)) Unknown 1 NW_019212886.1 weakly similar to Lachancea thermotolerans KLTH0E00176g hypothetical protein; 25191 34686847 LALA0_S08e00342g Lachancea lanzarotensis 24237 R 1245769 CDS LALA0_S08e00364g 34686848 complement(26529..27431) Unknown 1 NW_019212886.1 similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Putative protein of unknown function; proposed to be a palmitoylated membrane protein; uncharacterized protein 27431 34686848 LALA0_S08e00364g Lachancea lanzarotensis uncharacterized protein XP_022629565.1 26529 R 1245769 CDS LALA0_S08e00386g 34686849 28405..29430 Unknown 1 NW_019212886.1 similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; uncharacterized protein 29430 34686849 LALA0_S08e00386g Lachancea lanzarotensis uncharacterized protein XP_022629566.1 28405 D 1245769 CDS LALA0_S08e00408g 34686850 complement(30733..32505) Unknown 1 NW_019212886.1 similar to uniprot|Q6BVQ7 Debaryomyces hansenii DEHA2C00726g hypothetical protein; uncharacterized protein 32505 34686850 LALA0_S08e00408g Lachancea lanzarotensis uncharacterized protein XP_022629567.1 30733 R 1245769 CDS LALA0_S08e00430g 34686851 complement(33876..35534) Unknown 1 NW_019212886.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene; uncharacterized protein 35534 34686851 LALA0_S08e00430g Lachancea lanzarotensis uncharacterized protein XP_022629568.1 33876 R 1245769 CDS LALA0_S08e00452g 34686852 complement(37102..38763) Unknown 1 NW_019212886.1 similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane; uncharacterized protein 38763 34686852 LALA0_S08e00452g Lachancea lanzarotensis uncharacterized protein XP_022629569.1 37102 R 1245769 CDS LALA0_S08e00474g 34686853 40315..41226 Unknown 1 NW_019212886.1 similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p; uncharacterized protein 41226 34686853 LALA0_S08e00474g Lachancea lanzarotensis uncharacterized protein XP_022629570.1 40315 D 1245769 CDS LALA0_S08e00496g 34686854 42167..43174 Unknown 1 NW_019212886.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.; uncharacterized protein 43174 34686854 LALA0_S08e00496g Lachancea lanzarotensis uncharacterized protein XP_022629571.1 42167 D 1245769 CDS LALA0_S08e00518g 34686855 48401..50128 Unknown 1 NW_019212886.1 some similarities with uniprot|P25653 Saccharomyces cerevisiae YCR089W (ohnolog of YNR044W) FIG2 Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; uncharacterized protein 50128 34686855 LALA0_S08e00518g Lachancea lanzarotensis uncharacterized protein XP_022629572.1 48401 D 1245769 CDS LALA0_S08e00540g 34686856 complement(50610..51719) Unknown 1 NW_019212886.1 weakly similar to uniprot|P52923 Saccharomyces cerevisiae YNR074C AIF1 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; uncharacterized protein 51719 34686856 LALA0_S08e00540g Lachancea lanzarotensis uncharacterized protein XP_022629573.1 50610 R 1245769 CDS LALA0_S08e00562g 34686857 complement(52547..54067) Unknown 1 NW_019212886.1 weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; uncharacterized protein 54067 34686857 LALA0_S08e00562g Lachancea lanzarotensis uncharacterized protein XP_022629574.1 52547 R 1245769 CDS LALA0_S08e00584g 34686858 complement(55092..56633) Unknown 1 NW_019212886.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 56633 34686858 LALA0_S08e00584g Lachancea lanzarotensis uncharacterized protein XP_022629575.1 55092 R 1245769 CDS LALA0_S08e00606g 34686859 complement(57376..58365) Unknown 1 NW_019212886.1 similar to uniprot|C5DES4 Lachancea thermotolerans KLTH0C11682g hypothetical protein; uncharacterized protein 58365 34686859 LALA0_S08e00606g Lachancea lanzarotensis uncharacterized protein XP_022629576.1 57376 R 1245769 CDS LALA0_S08e00650g 34686861 complement(60776..61744) Unknown 1 NW_019212886.1 highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; uncharacterized protein 61744 34686861 LALA0_S08e00650g Lachancea lanzarotensis uncharacterized protein XP_022629577.1 60776 R 1245769 CDS LALA0_S08e00672g 34686862 complement(62324..62827) Unknown 1 NW_019212886.1 weakly similar to uniprot|C5DES4 Lachancea thermotolerans KLTH0C11682g hypothetical protein; uncharacterized protein 62827 34686862 LALA0_S08e00672g Lachancea lanzarotensis uncharacterized protein XP_022629578.1 62324 R 1245769 CDS LALA0_S08e00694g 34686863 complement(63192..65741) Unknown 1 NW_019212886.1 similar to uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; phosphatidylinositol phospholipase C 65741 34686863 LALA0_S08e00694g Lachancea lanzarotensis phosphatidylinositol phospholipase C XP_022629579.1 63192 R 1245769 CDS LALA0_S08e00716g 34686864 complement(65952..67712) Unknown 1 NW_019212886.1 weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase; uncharacterized protein 67712 34686864 LALA0_S08e00716g Lachancea lanzarotensis uncharacterized protein XP_022629580.1 65952 R 1245769 CDS LALA0_S08e00738g 34686865 complement(68094..70313) Unknown 1 NW_019212886.1 similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; ATP-binding cassette permease MDL2 70313 34686865 LALA0_S08e00738g Lachancea lanzarotensis ATP-binding cassette permease MDL2 XP_022629581.1 68094 R 1245769 CDS LALA0_S08e00760g 34686866 complement(71058..71246) Unknown 1 NW_019212886.1 similar to uniprot|P21306 Saccharomyces cerevisiae YPL271W ATP15 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; F1F0 ATP synthase subunit epsilon 71246 34686866 LALA0_S08e00760g Lachancea lanzarotensis F1F0 ATP synthase subunit epsilon XP_022629582.1 71058 R 1245769 CDS LALA0_S08e00782g 34686867 71638..74718 Unknown 1 NW_019212886.1 similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C POL5 DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA; DNA-directed DNA polymerase 74718 34686867 LALA0_S08e00782g Lachancea lanzarotensis DNA-directed DNA polymerase XP_022629583.1 71638 D 1245769 CDS LALA0_S08e00804g 34686868 join(75096..75374,75479..76615) Unknown 1 NW_019212886.1 weakly similar to uniprot|Q08984 Saccharomyces cerevisiae YPL272C Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene; uncharacterized protein 76615 34686868 LALA0_S08e00804g Lachancea lanzarotensis uncharacterized protein XP_022629584.1 75096 D 1245769 CDS LALA0_S08e00826g 34686869 complement(76689..77951) Unknown 1 NW_019212886.1 similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W HAT2 Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; uncharacterized protein 77951 34686869 LALA0_S08e00826g Lachancea lanzarotensis uncharacterized protein XP_022629585.1 76689 R 1245769 CDS LALA0_S08e00848g 34686870 complement(78377..80296) Unknown 1 NW_019212886.1 similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function; uncharacterized protein 80296 34686870 LALA0_S08e00848g Lachancea lanzarotensis uncharacterized protein XP_022629586.1 78377 R 1245769 CDS LALA0_S08e00870g 34686871 complement(81352..82992) Unknown 1 NW_019212886.1 similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors; phosphoacetylglucosamine mutase PCM1 82992 34686871 LALA0_S08e00870g Lachancea lanzarotensis phosphoacetylglucosamine mutase PCM1 XP_022629587.1 81352 R 1245769 CDS LALA0_S08e00892g 34686872 83218..83487 Unknown 1 NW_019212886.1 similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A SOM1 Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 83487 34686872 LALA0_S08e00892g Lachancea lanzarotensis uncharacterized protein XP_022629588.1 83218 D 1245769 CDS LALA0_S08e00914g 34686873 84895..86379 Unknown 1 NW_019212886.1 highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; fumarase FUM1 86379 34686873 LALA0_S08e00914g Lachancea lanzarotensis fumarase FUM1 XP_022629589.1 84895 D 1245769 CDS LALA0_S08e00936g 34686874 86736..88289 Unknown 1 NW_019212886.1 similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking; uncharacterized protein 88289 34686874 LALA0_S08e00936g Lachancea lanzarotensis uncharacterized protein XP_022629590.1 86736 D 1245769 CDS LALA0_S08e00958g 34686875 complement(88495..90984) Unknown 1 NW_019212886.1 weakly similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes; uncharacterized protein 90984 34686875 LALA0_S08e00958g Lachancea lanzarotensis uncharacterized protein XP_022629591.1 88495 R 1245769 CDS LALA0_S08e00980g 34686876 95720..97393 Unknown 1 NW_019212886.1 similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C (ohnolog of YOR003W) PRB1 Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; proteinase B 97393 34686876 LALA0_S08e00980g Lachancea lanzarotensis proteinase B XP_022629592.1 95720 D 1245769 CDS LALA0_S08e01002g 34686877 97885..98463 Unknown 1 NW_019212886.1 hypothetical protein; uncharacterized protein 98463 34686877 LALA0_S08e01002g Lachancea lanzarotensis uncharacterized protein XP_022629593.1 97885 D 1245769 CDS LALA0_S08e01024g 34686878 98730..99575 Unknown 1 NW_019212886.1 similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W UTP23 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; rRNA-binding ribosome biosynthesis protein UTP23 99575 34686878 LALA0_S08e01024g Lachancea lanzarotensis rRNA-binding ribosome biosynthesis protein UTP23 XP_022629594.1 98730 D 1245769 CDS LALA0_S08e01046g 34686879 100262..103135 Unknown 1 NW_019212886.1 similar to uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; kinesin motor protein CIN8 103135 34686879 LALA0_S08e01046g Lachancea lanzarotensis kinesin motor protein CIN8 XP_022629595.1 100262 D 1245769 CDS LALA0_S08e01068g 34686880 complement(103220..105280) Unknown 1 NW_019212886.1 similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline; nitrogen permease regulating protein NPR2 105280 34686880 LALA0_S08e01068g Lachancea lanzarotensis nitrogen permease regulating protein NPR2 XP_022629596.1 103220 R 1245769 CDS LALA0_S08e01090g 34686881 complement(106399..109242) Unknown 1 NW_019212886.1 similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; DNA ligase (ATP) DNL4 109242 34686881 LALA0_S08e01090g Lachancea lanzarotensis DNA ligase (ATP) DNL4 XP_022629597.1 106399 R 1245769 CDS LALA0_S08e01112g 34686882 complement(109463..110446) Unknown 1 NW_019212886.1 similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C TSR3 Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; ribosome biogenesis protein TSR3 110446 34686882 LALA0_S08e01112g Lachancea lanzarotensis ribosome biogenesis protein TSR3 XP_022629598.1 109463 R 1245769 CDS LALA0_S08e01134g 34686883 111360..114662 Unknown 1 NW_019212886.1 some similarities with uniprot|Q04263 Saccharomyces cerevisiae YML002W Putative protein of unknown function; expression induced by heat and by calcium shortage; uncharacterized protein 114662 34686883 LALA0_S08e01134g Lachancea lanzarotensis uncharacterized protein XP_022629599.1 111360 D 1245769 CDS LALA0_S08e01156g 34686884 complement(114701..115717) Unknown 1 NW_019212886.1 similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT; uncharacterized protein 115717 34686884 LALA0_S08e01156g Lachancea lanzarotensis uncharacterized protein XP_022629600.1 114701 R 1245769 CDS LALA0_S08e01200g 34686886 complement(116490..118100) Unknown 1 NW_019212886.1 similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase 118100 34686886 LALA0_S08e01200g Lachancea lanzarotensis dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase XP_022629601.1 116490 R 1245769 CDS LALA0_S08e01222g 34686887 complement(118626..119549) Unknown 1 NW_019212886.1 highly similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein; uncharacterized protein 119549 34686887 LALA0_S08e01222g Lachancea lanzarotensis uncharacterized protein XP_022629602.1 118626 R 1245769 CDS LALA0_S08e01244g 34686888 120968..121594 Unknown 1 NW_019212886.1 highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7; Rab family GTPase YPT7 121594 34686888 LALA0_S08e01244g Lachancea lanzarotensis Rab family GTPase YPT7 XP_022629603.1 120968 D 1245769 CDS LALA0_S08e01266g 34686889 122118..123062 Unknown 1 NW_019212886.1 similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling; uncharacterized protein 123062 34686889 LALA0_S08e01266g Lachancea lanzarotensis uncharacterized protein XP_022629604.1 122118 D 1245769 CDS LALA0_S08e01288g 34686890 123724..125925 Unknown 1 NW_019212886.1 similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; exosome nuclease subunit RRP6 125925 34686890 LALA0_S08e01288g Lachancea lanzarotensis exosome nuclease subunit RRP6 XP_022629605.1 123724 D 1245769 CDS LALA0_S08e01310g 34686891 126327..127286 Unknown 1 NW_019212886.1 similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc; PAQR-type receptor 127286 34686891 LALA0_S08e01310g Lachancea lanzarotensis PAQR-type receptor XP_022629606.1 126327 D 1245769 CDS LALA0_S08e01354g 34686893 128485..129618 Unknown 1 NW_019212886.1 similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C PFA4 Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases; palmitoyltransferase PFA4 129618 34686893 LALA0_S08e01354g Lachancea lanzarotensis palmitoyltransferase PFA4 XP_022629607.1 128485 D 1245769 CDS LALA0_S08e01376g 34686894 complement(129702..133970) Unknown 1 NW_019212886.1 similar to uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity; transcriptional regulator SIN3 133970 34686894 LALA0_S08e01376g Lachancea lanzarotensis transcriptional regulator SIN3 XP_022629608.1 129702 R 1245769 CDS LALA0_S08e01398g 34686895 134421..134789 Unknown 1 NW_019212886.1 highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C RPB11 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit; DNA-directed RNA polymerase II core subunit RPB11 134789 34686895 LALA0_S08e01398g Lachancea lanzarotensis DNA-directed RNA polymerase II core subunit RPB11 XP_022629609.1 134421 D 1245769 CDS LALA0_S08e01420g 34686896 complement(135104..137197) Unknown 1 NW_019212886.1 highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C CDC5 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate; polo kinase CDC5 137197 34686896 LALA0_S08e01420g Lachancea lanzarotensis polo kinase CDC5 XP_022629610.1 135104 R 1245769 CDS LALA0_S08e01442g 34686897 138528..140837 Unknown 1 NW_019212886.1 highly similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; DNA topoisomerase 1 140837 34686897 LALA0_S08e01442g Lachancea lanzarotensis DNA topoisomerase 1 XP_022629611.1 138528 D 1245769 CDS LALA0_S08e01464g 34686898 141149..142012 Unknown 1 NW_019212886.1 weakly similar to uniprot|Q08054 Saccharomyces cerevisiae YOL007C CSI2 Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene; uncharacterized protein 142012 34686898 LALA0_S08e01464g Lachancea lanzarotensis uncharacterized protein XP_022629612.1 141149 D 1245769 CDS LALA0_S08e01486g 34686899 142381..142854 Unknown 1 NW_019212886.1 similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W MIC17 Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 142854 34686899 LALA0_S08e01486g Lachancea lanzarotensis uncharacterized protein XP_022629613.1 142381 D 1245769 CDS LALA0_S08e01508g 34686900 143996..144802 Unknown 1 NW_019212886.1 some similarities with uniprot|Q03673 Saccharomyces cerevisiae YMR003W AIM34 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss; uncharacterized protein 144802 34686900 LALA0_S08e01508g Lachancea lanzarotensis uncharacterized protein XP_022629614.1 143996 D 1245769 CDS LALA0_S08e01530g 34686901 complement(144922..145539) Unknown 1 NW_019212886.1 weakly similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W COQ10 Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; ubiquinone-binding protein COQ10 145539 34686901 LALA0_S08e01530g Lachancea lanzarotensis ubiquinone-binding protein COQ10 XP_022629615.1 144922 R 1245769 CDS LALA0_S08e01552g 34686902 145689..146537 Unknown 1 NW_019212886.1 similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex subunit MDM12 146537 34686902 LALA0_S08e01552g Lachancea lanzarotensis ERMES complex subunit MDM12 XP_022629616.1 145689 D 1245769 CDS LALA0_S08e01574g 34686903 147218..148810 Unknown 1 NW_019212886.1 similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; uncharacterized protein 148810 34686903 LALA0_S08e01574g Lachancea lanzarotensis uncharacterized protein XP_022629617.1 147218 D 1245769 CDS LALA0_S08e01596g 34686904 complement(148938..150032) Unknown 1 NW_019212886.1 highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected; rRNA-processing endoribonuclease 150032 34686904 LALA0_S08e01596g Lachancea lanzarotensis rRNA-processing endoribonuclease XP_022629618.1 148938 R 1245769 CDS LALA0_S08e01618g 34686905 complement(150660..151313) Unknown 1 NW_019212886.1 weakly similar to uniprot|C5DEN2 Lachancea thermotolerans KLTH0C10626g hypothetical protein; uncharacterized protein 151313 34686905 LALA0_S08e01618g Lachancea lanzarotensis uncharacterized protein XP_022629619.1 150660 R 1245769 CDS LALA0_S08e01640g 34686906 153115..154332 Unknown 1 NW_019212886.1 similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate; uncharacterized protein 154332 34686906 LALA0_S08e01640g Lachancea lanzarotensis uncharacterized protein XP_022629620.1 153115 D 1245769 CDS LALA0_S08e01684g 34686908 complement(155122..157065) Unknown 1 NW_019212886.1 similar to uniprot|Q08108 Saccharomyces cerevisiae YOL011W (ohnolog of YMR008C) PLB3 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; lysophospholipase 157065 34686908 LALA0_S08e01684g Lachancea lanzarotensis lysophospholipase XP_022629621.1 155122 R 1245769 CDS LALA0_S08e01706g 34686909 158175..159887 Unknown 1 NW_019212886.1 highly similar to uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; uncharacterized protein 159887 34686909 LALA0_S08e01706g Lachancea lanzarotensis uncharacterized protein XP_022629622.1 158175 D 1245769 CDS LALA0_S08e01728g 34686910 160407..160811 Unknown 1 NW_019212886.1 highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; histone H2AZ 160811 34686910 LALA0_S08e01728g Lachancea lanzarotensis histone H2AZ XP_022629623.1 160407 D 1245769 CDS LALA0_S08e01750g 34686911 complement(160886..161341) Unknown 1 NW_019212886.1 similar to Lachancea thermotolerans KLTH0C10252g hypothetical protein; uncharacterized protein 161341 34686911 LALA0_S08e01750g Lachancea lanzarotensis uncharacterized protein XP_022629624.1 160886 R 1245769 CDS LALA0_S08e01772g 34686912 161852..163396 Unknown 1 NW_019212886.1 similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; E3 ubiquitin-protein ligase HRD1 163396 34686912 LALA0_S08e01772g Lachancea lanzarotensis E3 ubiquitin-protein ligase HRD1 XP_022629625.1 161852 D 1245769 CDS LALA0_S08e01794g 34686913 complement(163580..165040) Unknown 1 NW_019212886.1 similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; uncharacterized protein 165040 34686913 LALA0_S08e01794g Lachancea lanzarotensis uncharacterized protein XP_022629626.1 163580 R 1245769 CDS LALA0_S08e01838g 34686915 166083..167684 Unknown 1 NW_019212886.1 weakly similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Putative protein of unknown function, deletion confers reduced fitness in saline; uncharacterized protein 167684 34686915 LALA0_S08e01838g Lachancea lanzarotensis uncharacterized protein XP_022629627.1 166083 D 1245769 CDS LALA0_S08e01860g 34686916 complement(167990..169696) Unknown 1 NW_019212886.1 highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; chaperone ATPase HSP60 169696 34686916 LALA0_S08e01860g Lachancea lanzarotensis chaperone ATPase HSP60 XP_022629628.1 167990 R 1245769 CDS LALA0_S08e01882g 34686917 170837..172483 Unknown 1 NW_019212886.1 weakly similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; uncharacterized protein 172483 34686917 LALA0_S08e01882g Lachancea lanzarotensis uncharacterized protein XP_022629629.1 170837 D 1245769 CDS LALA0_S08e01904g 34686918 173626..175311 Unknown 1 NW_019212886.1 similar to uniprot|Q12246 Saccharomyces cerevisiae YOR171C (ohnolog of YLR260W) LCB4 Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; uncharacterized protein 175311 34686918 LALA0_S08e01904g Lachancea lanzarotensis uncharacterized protein XP_022629630.1 173626 D 1245769 CDS LALA0_S08e01926g 34686919 complement(175571..176215) Unknown 1 NW_019212886.1 highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6; Rab family GTPase YPT6 176215 34686919 LALA0_S08e01926g Lachancea lanzarotensis Rab family GTPase YPT6 XP_022629631.1 175571 R 1245769 CDS LALA0_S08e01948g 34686920 complement(177041..177235) Unknown 1 NW_019212886.1 highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A TMA7 Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; uncharacterized protein 177235 34686920 LALA0_S08e01948g Lachancea lanzarotensis uncharacterized protein XP_022629632.1 177041 R 1245769 CDS LALA0_S08e01970g 34686921 complement(177667..180090) Unknown 1 NW_019212886.1 highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions; glutamine--tRNA ligase 180090 34686921 LALA0_S08e01970g Lachancea lanzarotensis glutamine--tRNA ligase XP_022629633.1 177667 R 1245769 CDS LALA0_S08e01992g 34686922 join(180611..180898,181018..183018) Unknown 1 NW_019212886.1 weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p; uncharacterized protein 183018 34686922 LALA0_S08e01992g Lachancea lanzarotensis uncharacterized protein XP_022629634.1 180611 D 1245769 CDS LALA0_S08e02014g 34686923 183317..183520 Unknown 1 NW_019212886.1 some similarities with uniprot|Q3E7X9 Saccharomyces cerevisiae YOR167C (ohnolog of YLR264W) RPS28A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein; 40S ribosomal protein eS28 183520 34686923 LALA0_S08e02014g Lachancea lanzarotensis 40S ribosomal protein eS28 XP_022629635.1 183317 D 1245769 CDS LALA0_S08e02036g 34686924 184921..186282 Unknown 1 NW_019212886.1 similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C SWT1 RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain; mRNA-processing endoribonuclease 186282 34686924 LALA0_S08e02036g Lachancea lanzarotensis mRNA-processing endoribonuclease XP_022629636.1 184921 D 1245769 CDS LALA0_S08e02058g 34686925 complement(186309..187334) Unknown 1 NW_019212886.1 weakly similar to uniprot|C5DBL9 Lachancea thermotolerans KLTH0A03674g hypothetical protein; uncharacterized protein 187334 34686925 LALA0_S08e02058g Lachancea lanzarotensis uncharacterized protein XP_022629637.1 186309 R 1245769 CDS LALA0_S08e02080g 34686926 complement(187517..189925) Unknown 1 NW_019212886.1 similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3; dynamin-like GTPase SEY1 189925 34686926 LALA0_S08e02080g Lachancea lanzarotensis dynamin-like GTPase SEY1 XP_022629638.1 187517 R 1245769 CDS LALA0_S08e02102g 34686927 190976..191887 Unknown 1 NW_019212886.1 similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C GET4 Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20; uncharacterized protein 191887 34686927 LALA0_S08e02102g Lachancea lanzarotensis uncharacterized protein XP_022629639.1 190976 D 1245769 CDS LALA0_S08e02124g 34686928 complement(192029..192571) Unknown 1 NW_019212886.1 similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa-and pentaphosphates; exhibits endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; member of the MutT family of nucleotide hydrolases; polyphosphatase DDP1 192571 34686928 LALA0_S08e02124g Lachancea lanzarotensis polyphosphatase DDP1 XP_022629640.1 192029 R 1245769 CDS LALA0_S08e02146g 34686929 complement(193053..194861) Unknown 1 NW_019212886.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations; uncharacterized protein 194861 34686929 LALA0_S08e02146g Lachancea lanzarotensis uncharacterized protein XP_022629641.1 193053 R 1245769 CDS LALA0_S08e02168g 34686930 complement(195661..197445) Unknown 1 NW_019212886.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations; uncharacterized protein 197445 34686930 LALA0_S08e02168g Lachancea lanzarotensis uncharacterized protein XP_022629642.1 195661 R 1245769 CDS LALA0_S08e02190g 34686931 199021..201336 Unknown 1 NW_019212886.1 weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W (ohnolog of YLR266C) YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes; uncharacterized protein 201336 34686931 LALA0_S08e02190g Lachancea lanzarotensis uncharacterized protein XP_022629643.1 199021 D 1245769 CDS LALA0_S08e02212g 34686932 201980..202714 Unknown 1 NW_019212886.1 similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p; protein disulfide isomerase MPD2 202714 34686932 LALA0_S08e02212g Lachancea lanzarotensis protein disulfide isomerase MPD2 XP_022629644.1 201980 D 1245769 CDS LALA0_S08e02234g 34686933 complement(202737..203651) Unknown 1 NW_019212886.1 similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; uncharacterized protein 203651 34686933 LALA0_S08e02234g Lachancea lanzarotensis uncharacterized protein XP_022629645.1 202737 R 1245769 CDS LALA0_S08e02256g 34686934 204351..207068 Unknown 1 NW_019212886.1 weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 207068 34686934 LALA0_S08e02256g Lachancea lanzarotensis uncharacterized protein XP_022629646.1 204351 D 1245769 CDS LALA0_S08e02278g 34686935 complement(207221..208189) Unknown 1 NW_019212886.1 similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product; D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 208189 34686935 LALA0_S08e02278g Lachancea lanzarotensis D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 XP_022629647.1 207221 R 1245769 CDS LALA0_S08e02300g 34686936 complement(208806..211676) Unknown 1 NW_019212886.1 highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP; mismatch repair ATPase MSH2 211676 34686936 LALA0_S08e02300g Lachancea lanzarotensis mismatch repair ATPase MSH2 XP_022629648.1 208806 R 1245769 CDS LALA0_S08e02322g 34686937 complement(212365..214629) Unknown 1 NW_019212886.1 weakly similar to uniprot|P38280 Saccharomyces cerevisiae YBR148W (ohnolog of YOL091W) YSW1 Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; uncharacterized protein 214629 34686937 LALA0_S08e02322g Lachancea lanzarotensis uncharacterized protein XP_022629649.1 212365 R 1245769 CDS LALA0_S08e02344g 34686938 complement(214985..215914) Unknown 1 NW_019212886.1 similar to uniprot|P38279 Saccharomyces cerevisiae YBR147W (ohnolog of YOL092W) RTC2 Protein of unknown function; mutant produces large lipid droplets, is resistant to fluconazole, has decreased levels of rDNA transcription, growth defects on minimal media, and suppresses cdc13-1; detected in highly purified mitochondria; similar to a G-protein coupled receptor from S. pombe; cationic amino acid transporter 215914 34686938 LALA0_S08e02344g Lachancea lanzarotensis cationic amino acid transporter XP_022629650.1 214985 R 1245769 CDS LALA0_S08e02366g 34686939 complement(216587..217588) Unknown 1 NW_019212886.1 similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W TRM10 tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs; tRNA (guanine(9)-N(1))-methyltransferase 217588 34686939 LALA0_S08e02366g Lachancea lanzarotensis tRNA (guanine(9)-N(1))-methyltransferase XP_022629651.1 216587 R 1245769 CDS LALA0_S08e02388g 34686940 217817..218785 Unknown 1 NW_019212886.1 highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 4 218785 34686940 LALA0_S08e02388g Lachancea lanzarotensis replication factor C subunit 4 XP_022629652.1 217817 D 1245769 CDS LALA0_S08e02410g 34686941 218966..220720 Unknown 1 NW_019212886.1 similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W VPS52 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin; uncharacterized protein 220720 34686941 LALA0_S08e02410g Lachancea lanzarotensis uncharacterized protein XP_022629653.1 218966 D 1245769 CDS LALA0_S08e02432g 34686942 220900..223038 Unknown 1 NW_019212886.1 similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD; ATP-dependent 3'-5' DNA helicase 223038 34686942 LALA0_S08e02432g Lachancea lanzarotensis ATP-dependent 3'-5' DNA helicase XP_022629654.1 220900 D 1245769 CDS LALA0_S08e02454g 34686943 complement(223050..225098) Unknown 1 NW_019212886.1 similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting; uncharacterized protein 225098 34686943 LALA0_S08e02454g Lachancea lanzarotensis uncharacterized protein XP_022629655.1 223050 R 1245769 CDS LALA0_S08e02476g 34686944 225342..226277 Unknown 1 NW_019212886.1 similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C COQ3 O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; hexaprenyldihydroxybenzoate methyltransferase 226277 34686944 LALA0_S08e02476g Lachancea lanzarotensis hexaprenyldihydroxybenzoate methyltransferase XP_022629656.1 225342 D 1245769 CDS LALA0_S08e02498g 34686945 complement(226368..227057) Unknown 1 NW_019212886.1 similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p; uncharacterized protein 227057 34686945 LALA0_S08e02498g Lachancea lanzarotensis uncharacterized protein XP_022629657.1 226368 R 1245769 CDS LALA0_S08e02520g 34686946 227873..229141 Unknown 1 NW_019212886.1 highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA; tryptophan--tRNA ligase WRS1 229141 34686946 LALA0_S08e02520g Lachancea lanzarotensis tryptophan--tRNA ligase WRS1 XP_022629658.1 227873 D 1245769 CDS LALA0_S08e02542g 34686947 complement(229256..229894) Unknown 1 NW_019212886.1 similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration; 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 229894 34686947 LALA0_S08e02542g Lachancea lanzarotensis 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 XP_022629659.1 229256 R 1245769 CDS LALA0_S08e02586g 34686949 complement(231310..233058) Unknown 1 NW_019212886.1 weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8; dynein intermediate chain 233058 34686949 LALA0_S08e02586g Lachancea lanzarotensis dynein intermediate chain XP_022629660.1 231310 R 1245769 CDS LALA0_S08e02608g 34686950 233228..234112 Unknown 1 NW_019212886.1 similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; DNA replication protein SLD5 234112 34686950 LALA0_S08e02608g Lachancea lanzarotensis DNA replication protein SLD5 XP_022629661.1 233228 D 1245769 CDS LALA0_S08e02630g 34686951 235227..236150 Unknown 1 NW_019212886.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; uncharacterized protein 236150 34686951 LALA0_S08e02630g Lachancea lanzarotensis uncharacterized protein XP_022629662.1 235227 D 1245769 CDS LALA0_S08e02652g 34686952 237948..239666 Unknown 1 NW_019212886.1 similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; proline permease PUT4 239666 34686952 LALA0_S08e02652g Lachancea lanzarotensis proline permease PUT4 XP_022629663.1 237948 D 1245769 CDS LALA0_S08e02674g 34686953 241072..242493 Unknown 1 NW_019212886.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; uncharacterized protein 242493 34686953 LALA0_S08e02674g Lachancea lanzarotensis uncharacterized protein XP_022629664.1 241072 D 1245769 CDS LALA0_S08e02696g 34686954 243375..245054 Unknown 1 NW_019212886.1 similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; uncharacterized protein 245054 34686954 LALA0_S08e02696g Lachancea lanzarotensis uncharacterized protein XP_022629665.1 243375 D 1245769 CDS LALA0_S08e02718g 34686955 complement(245534..245926) Unknown 1 NW_019212886.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes; uncharacterized protein 245926 34686955 LALA0_S08e02718g Lachancea lanzarotensis uncharacterized protein XP_022629666.1 245534 R 1245769 CDS LALA0_S08e02740g 34686956 247315..248655 Unknown 1 NW_019212886.1 similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain; ubiquinol--cytochrome-c reductase subunit COR1 248655 34686956 LALA0_S08e02740g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit COR1 XP_022629667.1 247315 D 1245769 CDS LALA0_S08e02762g 34686957 complement(249033..250283) Unknown 1 NW_019212886.1 weakly similar to uniprot|P38193 Saccharomyces cerevisiae YBL046W PSY4 Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2; uncharacterized protein 250283 34686957 LALA0_S08e02762g Lachancea lanzarotensis uncharacterized protein XP_022629668.1 249033 R 1245769 CDS LALA0_S08e02784g 34686958 251772..252590 Unknown 1 NW_019212886.1 similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein; mitochondrial 37S ribosomal protein uS7m 252590 34686958 LALA0_S08e02784g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS7m XP_022629669.1 251772 D 1245769 CDS LALA0_S08e02806g 34686959 complement(join(252684..252986,252988..253071)) Unknown 1 NW_019212886.1 similar to uniprot|Q3E743 Saccharomyces cerevisiae YJR112W-A Putative protein of unknown function; identified based on homology to Ashbya gossypii; 253071 34686959 LALA0_S08e02806g Lachancea lanzarotensis 252684 R 1245769 CDS LALA0_S08e02850g 34686961 253670..257596 Unknown 1 NW_019212886.1 similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; uncharacterized protein 257596 34686961 LALA0_S08e02850g Lachancea lanzarotensis uncharacterized protein XP_022629670.1 253670 D 1245769 CDS LALA0_S08e02872g 34686962 complement(257663..258271) Unknown 1 NW_019212886.1 similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; MIND complex subunit NNF1 258271 34686962 LALA0_S08e02872g Lachancea lanzarotensis MIND complex subunit NNF1 XP_022629671.1 257663 R 1245769 CDS LALA0_S08e02894g 34686963 259394..262798 Unknown 1 NW_019212886.1 highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus; uncharacterized protein 262798 34686963 LALA0_S08e02894g Lachancea lanzarotensis uncharacterized protein XP_022629672.1 259394 D 1245769 CDS LALA0_S08e02916g 34686964 complement(262847..265432) Unknown 1 NW_019212886.1 similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency; uncharacterized protein 265432 34686964 LALA0_S08e02916g Lachancea lanzarotensis uncharacterized protein XP_022629673.1 262847 R 1245769 CDS LALA0_S08e02938g 34686965 join(266727..266778,266888..267729) Unknown 1 NW_019212886.1 highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; ATP phosphoribosyltransferase 267729 34686965 LALA0_S08e02938g Lachancea lanzarotensis ATP phosphoribosyltransferase XP_022629674.1 266727 D 1245769 CDS LALA0_S08e02960g 34686966 270056..271903 Unknown 1 NW_019212886.1 similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 271903 34686966 LALA0_S08e02960g Lachancea lanzarotensis ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 XP_022629675.1 270056 D 1245769 CDS LALA0_S08e02982g 34686967 272850..274181 Unknown 1 NW_019212886.1 weakly similar to uniprot|P40187 Saccharomyces cerevisiae YIL045W (ohnolog of YER054C) PIG2 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; uncharacterized protein 274181 34686967 LALA0_S08e02982g Lachancea lanzarotensis uncharacterized protein XP_022629676.1 272850 D 1245769 CDS LALA0_S08e03004g 34686968 275998..276117 Unknown 1 NW_019212886.1 similar to uniprot|Q3E7B0 Saccharomyces cerevisiae YER053C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; uncharacterized protein 276117 34686968 LALA0_S08e03004g Lachancea lanzarotensis uncharacterized protein XP_022629677.1 275998 D 1245769 CDS LALA0_S08e03026g 34686969 277204..278127 Unknown 1 NW_019212886.1 similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature; Cu/Pi carrier 278127 34686969 LALA0_S08e03026g Lachancea lanzarotensis Cu/Pi carrier XP_022629678.1 277204 D 1245769 CDS LALA0_S08e03048g 34686970 complement(278241..279032) Unknown 1 NW_019212886.1 similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif; GTPase-activating protein AGE2 279032 34686970 LALA0_S08e03048g Lachancea lanzarotensis GTPase-activating protein AGE2 XP_022629679.1 278241 R 1245769 CDS LALA0_S08e03070g 34686971 279377..280051 Unknown 1 NW_019212886.1 some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; uncharacterized protein 280051 34686971 LALA0_S08e03070g Lachancea lanzarotensis uncharacterized protein XP_022629680.1 279377 D 1245769 CDS LALA0_S08e03092g 34686972 280643..282211 Unknown 1 NW_019212886.1 highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; aspartate kinase 282211 34686972 LALA0_S08e03092g Lachancea lanzarotensis aspartate kinase XP_022629681.1 280643 D 1245769 CDS LALA0_S08e03114g 34686973 complement(282459..283307) Unknown 1 NW_019212886.1 similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia; cytochrome-b5 reductase 283307 34686973 LALA0_S08e03114g Lachancea lanzarotensis cytochrome-b5 reductase XP_022629682.1 282459 R 1245769 CDS LALA0_S08e03136g 34686974 complement(283547..284968) Unknown 1 NW_019212886.1 similar to uniprot|P40034 Saccharomyces cerevisiae YER051W JHD1 JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; [Histone H3]-lysine-36 demethylase 284968 34686974 LALA0_S08e03136g Lachancea lanzarotensis [Histone H3]-lysine-36 demethylase XP_022629683.1 283547 R 1245769 CDS LALA0_S08e03158g 34686975 286080..286598 Unknown 1 NW_019212886.1 similar to uniprot|P40033 Saccharomyces cerevisiae YER050C RSM18 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein; mitochondrial 37S ribosomal protein bS18m 286598 34686975 LALA0_S08e03158g Lachancea lanzarotensis mitochondrial 37S ribosomal protein bS18m XP_022629684.1 286080 D 1245769 CDS LALA0_S08e03180g 34686976 complement(286730..287983) Unknown 1 NW_019212886.1 similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p; protein kinase PKP1 287983 34686976 LALA0_S08e03180g Lachancea lanzarotensis protein kinase PKP1 XP_022629685.1 286730 R 1245769 CDS LALA0_S08e03202g 34686977 288294..289265 Unknown 1 NW_019212886.1 similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis; uncharacterized protein 289265 34686977 LALA0_S08e03202g Lachancea lanzarotensis uncharacterized protein XP_022629686.1 288294 D 1245769 CDS LALA0_S08e03224g 34686978 complement(289326..291209) Unknown 1 NW_019212886.1 similar to uniprot|P40032 Saccharomyces cerevisiae YER049W TPA1 Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate; oxidative DNA demethylase 291209 34686978 LALA0_S08e03224g Lachancea lanzarotensis oxidative DNA demethylase XP_022629687.1 289326 R 1245769 CDS LALA0_S08e03246g 34686979 complement(291576..291869) Unknown 1 NW_019212886.1 similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A ISD11 Protein required for mitochondrial iron-sulfur cluster biosynthesis; uncharacterized protein 291869 34686979 LALA0_S08e03246g Lachancea lanzarotensis uncharacterized protein XP_022629688.1 291576 R 1245769 CDS LALA0_S08e03290g 34686981 293200..293649 Unknown 1 NW_019212886.1 weakly similar to uniprot|P40532 Saccharomyces cerevisiae YIL040W APQ12 Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; uncharacterized protein 293649 34686981 LALA0_S08e03290g Lachancea lanzarotensis uncharacterized protein XP_022629689.1 293200 D 1245769 CDS LALA0_S08e03312g 34686982 294042..295244 Unknown 1 NW_019212886.1 similar to uniprot|P39101 Saccharomyces cerevisiae YER048C CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; uncharacterized protein 295244 34686982 LALA0_S08e03312g Lachancea lanzarotensis uncharacterized protein XP_022629690.1 294042 D 1245769 CDS LALA0_S08e03334g 34686983 295422..296861 Unknown 1 NW_019212886.1 similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W TED1 Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); uncharacterized protein 296861 34686983 LALA0_S08e03334g Lachancea lanzarotensis uncharacterized protein XP_022629691.1 295422 D 1245769 CDS LALA0_S08e03356g 34686984 297308..299650 Unknown 1 NW_019212886.1 similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system; uncharacterized protein 299650 34686984 LALA0_S08e03356g Lachancea lanzarotensis uncharacterized protein XP_022629692.1 297308 D 1245769 CDS LALA0_S08e03378g 34686985 300251..301384 Unknown 1 NW_019212886.1 highly similar to uniprot|C5DBJ4 Lachancea thermotolerans KLTH0A03124g hypothetical protein; uncharacterized protein 301384 34686985 LALA0_S08e03378g Lachancea lanzarotensis uncharacterized protein XP_022629693.1 300251 D 1245769 CDS LALA0_S08e03400g 34686986 complement(301592..303949) Unknown 1 NW_019212886.1 similar to uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; CCR4-NOT core subunit NOT3 303949 34686986 LALA0_S08e03400g Lachancea lanzarotensis CCR4-NOT core subunit NOT3 XP_022629694.1 301592 R 1245769 CDS LALA0_S08e03422g 34686987 complement(304287..306122) Unknown 1 NW_019212886.1 weakly similar to uniprot|P40534 Saccharomyces cerevisiae YIL037C PRM2 Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion; pheromone-regulated protein PRM2 306122 34686987 LALA0_S08e03422g Lachancea lanzarotensis pheromone-regulated protein PRM2 XP_022629695.1 304287 R 1245769 CDS LALA0_S08e03444g 34686988 complement(306256..306993) Unknown 1 NW_019212886.1 some similarities with uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis; uncharacterized protein 306993 34686988 LALA0_S08e03444g Lachancea lanzarotensis uncharacterized protein XP_022629696.1 306256 R 1245769 CDS LALA0_S08e03466g 34686989 308665..309885 Unknown 1 NW_019212886.1 some similarities with uniprot|P40535 Saccharomyces cerevisiae YIL036W (ohnolog of YER045C) CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; uncharacterized protein 309885 34686989 LALA0_S08e03466g Lachancea lanzarotensis uncharacterized protein XP_022629697.1 308665 D 1245769 CDS LALA0_S08e03488g 34686990 join(311091..311138,311226..312341) Unknown 1 NW_019212886.1 weakly similar to uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores; uncharacterized protein 312341 34686990 LALA0_S08e03488g Lachancea lanzarotensis uncharacterized protein XP_022629698.1 311091 D 1245769 CDS LALA0_S08e03510g 34686991 complement(312394..313518) Unknown 1 NW_019212886.1 highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; casein kinase 2 catalytic subunit CKA1 313518 34686991 LALA0_S08e03510g Lachancea lanzarotensis casein kinase 2 catalytic subunit CKA1 XP_022629699.1 312394 R 1245769 CDS LALA0_S08e03532g 34686992 complement(313934..314764) Unknown 1 NW_019212886.1 similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; F-actin-capping protein subunit beta 314764 34686992 LALA0_S08e03532g Lachancea lanzarotensis F-actin-capping protein subunit beta XP_022629700.1 313934 R 1245769 CDS LALA0_S08e03554g 34686993 316716..317633 Unknown 1 NW_019212886.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; uncharacterized protein 317633 34686993 LALA0_S08e03554g Lachancea lanzarotensis uncharacterized protein XP_022629701.1 316716 D 1245769 CDS LALA0_S08e03576g 34686994 317902..318348 Unknown 1 NW_019212886.1 highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p; uncharacterized protein 318348 34686994 LALA0_S08e03576g Lachancea lanzarotensis uncharacterized protein XP_022629702.1 317902 D 1245769 CDS LALA0_S08e03598g 34686995 complement(318525..319925) Unknown 1 NW_019212886.1 similar to uniprot|P07278 Saccharomyces cerevisiae YIL033C BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; cAMP-dependent protein kinase regulatory subunit BCY1 319925 34686995 LALA0_S08e03598g Lachancea lanzarotensis cAMP-dependent protein kinase regulatory subunit BCY1 XP_022629703.1 318525 R 1245769 CDS LALA0_S08e03620g 34686996 complement(320511..322922) Unknown 1 NW_019212886.1 similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W IRC5 Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; uncharacterized protein 322922 34686996 LALA0_S08e03620g Lachancea lanzarotensis uncharacterized protein XP_022629704.1 320511 R 1245769 CDS LALA0_S08e03642g 34686997 323427..325163 Unknown 1 NW_019212886.1 similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters; uncharacterized protein 325163 34686997 LALA0_S08e03642g Lachancea lanzarotensis uncharacterized protein XP_022629705.1 323427 D 1245769 CDS LALA0_S08e03664g 34686998 326398..327105 Unknown 1 NW_019212886.1 similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; uncharacterized protein 327105 34686998 LALA0_S08e03664g Lachancea lanzarotensis uncharacterized protein XP_022629706.1 326398 D 1245769 CDS LALA0_S08e03686g 34686999 complement(327245..328693) Unknown 1 NW_019212886.1 highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; adenylosuccinase ADE13 328693 34686999 LALA0_S08e03686g Lachancea lanzarotensis adenylosuccinase ADE13 XP_022629707.1 327245 R 1245769 CDS LALA0_S08e03708g 34687000 complement(329510..332134) Unknown 1 NW_019212886.1 similar to uniprot|P53236 Saccharomyces cerevisiae YGR056W (ohnolog of YLR357W) RSC1 Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; uncharacterized protein 332134 34687000 LALA0_S08e03708g Lachancea lanzarotensis uncharacterized protein XP_022629708.1 329510 R 1245769 CDS LALA0_S08e03730g 34687001 332746..333849 Unknown 1 NW_019212886.1 weakly similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; uncharacterized protein 333849 34687001 LALA0_S08e03730g Lachancea lanzarotensis uncharacterized protein XP_022629709.1 332746 D 1245769 CDS LALA0_S08e03752g 34687002 complement(333949..335592) Unknown 1 NW_019212886.1 highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; uncharacterized protein 335592 34687002 LALA0_S08e03752g Lachancea lanzarotensis uncharacterized protein XP_022629710.1 333949 R 1245769 CDS LALA0_S08e03774g 34687003 337935..339206 Unknown 1 NW_019212886.1 similar to uniprot|D6VTK4 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone; seventransmembrane-domain GPCR that interacts with bothpheromone and a heterotrimeric G protein to initiate thesignaling response that leads to mating between haploid aand alpha cells; alpha-factor pheromone receptor STE2 339206 34687003 LALA0_S08e03774g Lachancea lanzarotensis alpha-factor pheromone receptor STE2 XP_022629711.1 337935 D 1245769 CDS LALA0_S08e03796g 34687004 complement(339380..342463) Unknown 1 NW_019212886.1 similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; uncharacterized protein 342463 34687004 LALA0_S08e03796g Lachancea lanzarotensis uncharacterized protein XP_022629712.1 339380 R 1245769 CDS LALA0_S08e03818g 34687005 complement(342979..345342) Unknown 1 NW_019212886.1 similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb; uncharacterized protein 345342 34687005 LALA0_S08e03818g Lachancea lanzarotensis uncharacterized protein XP_022629713.1 342979 R 1245769 CDS LALA0_S08e03840g 34687006 347446..348099 Unknown 1 NW_019212886.1 weakly similar to uniprot|P39552 Saccharomyces cerevisiae YAR033W MST28 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles; 348099 34687006 LALA0_S08e03840g Lachancea lanzarotensis 347446 D 1245769 CDS LALA0_S08e03862g 34687007 349833..352058 Unknown 1 NW_019212886.1 similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; uncharacterized protein 352058 34687007 LALA0_S08e03862g Lachancea lanzarotensis uncharacterized protein XP_022629714.1 349833 D 1245769 CDS LALA0_S08e03884g 34687008 353800..355047 Unknown 1 NW_019212886.1 weakly similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; uncharacterized protein 355047 34687008 LALA0_S08e03884g Lachancea lanzarotensis uncharacterized protein XP_022629715.1 353800 D 1245769 CDS LALA0_S08e03906g 34687009 join(355414..355441,355518..357499) Unknown 1 NW_019212886.1 similar to uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall; uncharacterized protein 357499 34687009 LALA0_S08e03906g Lachancea lanzarotensis uncharacterized protein XP_022629716.1 355414 D 1245769 CDS LALA0_S08e03928g 34687010 358819..359487 Unknown 1 NW_019212886.1 weakly similar to Lachancea thermotolerans KLTH0A02838g hypothetical protein; uncharacterized protein 359487 34687010 LALA0_S08e03928g Lachancea lanzarotensis uncharacterized protein XP_022629717.1 358819 D 1245769 CDS LALA0_S08e03950g 34687011 complement(359681..361180) Unknown 1 NW_019212886.1 highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C FRS2 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar; phenylalanine--tRNA ligase subunit alpha 361180 34687011 LALA0_S08e03950g Lachancea lanzarotensis phenylalanine--tRNA ligase subunit alpha XP_022629718.1 359681 R 1245769 CDS LALA0_S08e03972g 34687012 complement(361742..362428) Unknown 1 NW_019212886.1 weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex; uncharacterized protein 362428 34687012 LALA0_S08e03972g Lachancea lanzarotensis uncharacterized protein XP_022629719.1 361742 R 1245769 CDS LALA0_S08e03994g 34687013 362635..363321 Unknown 1 NW_019212886.1 similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C FCF2 Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; uncharacterized protein 363321 34687013 LALA0_S08e03994g Lachancea lanzarotensis uncharacterized protein XP_022629720.1 362635 D 1245769 CDS LALA0_S08e04016g 34687014 366076..368061 Unknown 1 NW_019212886.1 weakly similar to uniprot|P43574 Saccharomyces cerevisiae YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; uncharacterized protein 368061 34687014 LALA0_S08e04016g Lachancea lanzarotensis uncharacterized protein XP_022629721.1 366076 D 1245769 CDS LALA0_S08e04060g 34687016 complement(368888..370384) Unknown 1 NW_019212886.1 highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C (ohnolog of YPL017C) LPD1 Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; dihydrolipoyl dehydrogenase 370384 34687016 LALA0_S08e04060g Lachancea lanzarotensis dihydrolipoyl dehydrogenase XP_022629722.1 368888 R 1245769 CDS LALA0_S08e04104g 34687018 join(371748..371774,371840..372043) Unknown 1 NW_019212886.1 similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2 Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G; mRNA splicing protein SMX2 372043 34687018 LALA0_S08e04104g Lachancea lanzarotensis mRNA splicing protein SMX2 XP_022629723.1 371748 D 1245769 CDS LALA0_S08e04126g 34687019 complement(372134..372607) Unknown 1 NW_019212886.1 similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA; glucosamine 6-phosphate N-acetyltransferase 372607 34687019 LALA0_S08e04126g Lachancea lanzarotensis glucosamine 6-phosphate N-acetyltransferase XP_022629724.1 372134 R 1245769 CDS LALA0_S08e04148g 34687020 complement(372944..373456) Unknown 1 NW_019212886.1 similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene; uncharacterized protein 373456 34687020 LALA0_S08e04148g Lachancea lanzarotensis uncharacterized protein XP_022629725.1 372944 R 1245769 CDS LALA0_S08e04170g 34687021 complement(374214..375695) Unknown 1 NW_019212886.1 similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones; uncharacterized protein 375695 34687021 LALA0_S08e04170g Lachancea lanzarotensis uncharacterized protein XP_022629726.1 374214 R 1245769 CDS LALA0_S08e04192g 34687022 378566..379975 Unknown 1 NW_019212886.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 379975 34687022 LALA0_S08e04192g Lachancea lanzarotensis uncharacterized protein XP_022629727.1 378566 D 1245769 CDS LALA0_S08e04214g 34687023 382395..382712 Unknown 1 NW_019212886.1 similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; regulated by HOG and Ras-Pka pathways; lipid-binding protein HSP12 382712 34687023 LALA0_S08e04214g Lachancea lanzarotensis lipid-binding protein HSP12 XP_022629728.1 382395 D 1245769 CDS LALA0_S08e04236g 34687024 383481..384212 Unknown 1 NW_019212886.1 weakly similar to uniprot|C5DBH9 Lachancea thermotolerans KLTH0A02772g hypothetical protein; uncharacterized protein 384212 34687024 LALA0_S08e04236g Lachancea lanzarotensis uncharacterized protein XP_022629729.1 383481 D 1245769 CDS LALA0_S08e04258g 34687025 complement(384230..386209) Unknown 1 NW_019212886.1 similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex; uncharacterized protein 386209 34687025 LALA0_S08e04258g Lachancea lanzarotensis uncharacterized protein XP_022629730.1 384230 R 1245769 CDS LALA0_S08e04280g 34687026 complement(386552..387220) Unknown 1 NW_019212886.1 similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1; uncharacterized protein 387220 34687026 LALA0_S08e04280g Lachancea lanzarotensis uncharacterized protein XP_022629731.1 386552 R 1245769 CDS LALA0_S08e04302g 34687027 complement(387636..388733) Unknown 1 NW_019212886.1 similar to uniprot|C5DBH7 Lachancea thermotolerans KLTH0A02728g hypothetical protein; uncharacterized protein 388733 34687027 LALA0_S08e04302g Lachancea lanzarotensis uncharacterized protein XP_022629732.1 387636 R 1245769 CDS LALA0_S08e04324g 34687028 389452..391587 Unknown 1 NW_019212886.1 similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; SCF ubiquitin ligase complex subunit CDC4 391587 34687028 LALA0_S08e04324g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit CDC4 XP_022629733.1 389452 D 1245769 CDS LALA0_S08e04346g 34687029 391963..392403 Unknown 1 NW_019212886.1 similar to uniprot|C5DCQ7 Lachancea thermotolerans KLTH0B05038g hypothetical protein; uncharacterized protein 392403 34687029 LALA0_S08e04346g Lachancea lanzarotensis uncharacterized protein XP_022629734.1 391963 D 1245769 CDS LALA0_S08e04368g 34687030 392734..396420 Unknown 1 NW_019212886.1 similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; cohesin subunit SMC1 396420 34687030 LALA0_S08e04368g Lachancea lanzarotensis cohesin subunit SMC1 XP_022629735.1 392734 D 1245769 CDS LALA0_S08e04390g 34687031 396820..403272 Unknown 1 NW_019212886.1 similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM10 Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200; uncharacterized protein 403272 34687031 LALA0_S08e04390g Lachancea lanzarotensis uncharacterized protein XP_022629736.1 396820 D 1245769 CDS LALA0_S08e04412g 34687032 403679..404320 Unknown 1 NW_019212886.1 highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; Rab family GTPase SEC4 404320 34687032 LALA0_S08e04412g Lachancea lanzarotensis Rab family GTPase SEC4 XP_022629737.1 403679 D 1245769 CDS LALA0_S08e04434g 34687033 join(404917..405222,405225..405563,405563..405916,405916..406302) Unknown 1 NW_019212886.1 some similarities with uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein; 406302 34687033 LALA0_S08e04434g Lachancea lanzarotensis 404917 D 1245769 CDS LALA0_S08e04456g 34687034 complement(406353..407717) Unknown 1 NW_019212886.1 similar to uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein; uncharacterized protein 407717 34687034 LALA0_S08e04456g Lachancea lanzarotensis uncharacterized protein XP_022629738.1 406353 R 1245769 CDS LALA0_S08e04478g 34687035 408449..410953 Unknown 1 NW_019212886.1 similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W (ohnolog of YPL019C) VTC2 Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; vacuolar transporter chaperone 410953 34687035 LALA0_S08e04478g Lachancea lanzarotensis vacuolar transporter chaperone XP_022629739.1 408449 D 1245769 CDS LALA0_S08e04500g 34687036 411556..413889 Unknown 1 NW_019212886.1 similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 Protein of unknown function involved in vacuolar protein sorting; uncharacterized protein 413889 34687036 LALA0_S08e04500g Lachancea lanzarotensis uncharacterized protein XP_022629740.1 411556 D 1245769 CDS LALA0_S08e04522g 34687037 414085..414642 Unknown 1 NW_019212886.1 highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria; peptidylprolyl isomerase CPR3 414642 34687037 LALA0_S08e04522g Lachancea lanzarotensis peptidylprolyl isomerase CPR3 XP_022629741.1 414085 D 1245769 CDS LALA0_S08e04544g 34687038 415042..416244 Unknown 1 NW_019212886.1 similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p; uncharacterized protein 416244 34687038 LALA0_S08e04544g Lachancea lanzarotensis uncharacterized protein XP_022629742.1 415042 D 1245769 CDS LALA0_S08e04566g 34687039 join(416485..416521,416605..417044) Unknown 1 NW_019212886.1 similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi; TRAPP subunit BET5 417044 34687039 LALA0_S08e04566g Lachancea lanzarotensis TRAPP subunit BET5 XP_022629743.1 416485 D 1245769 CDS LALA0_S08e04588g 34687040 complement(417131..419806) Unknown 1 NW_019212886.1 weakly similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively; uncharacterized protein 419806 34687040 LALA0_S08e04588g Lachancea lanzarotensis uncharacterized protein XP_022629744.1 417131 R 1245769 CDS LALA0_S08e04610g 34687041 420321..420923 Unknown 1 NW_019212886.1 hypothetical protein; uncharacterized protein 420923 34687041 LALA0_S08e04610g Lachancea lanzarotensis uncharacterized protein XP_022629745.1 420321 D 1245769 CDS LALA0_S08e04632g 34687042 complement(421326..424490) Unknown 1 NW_019212886.1 similar to uniprot|P12683 Saccharomyces cerevisiae YML075C (ohnolog of YLR450W) HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 424490 34687042 LALA0_S08e04632g Lachancea lanzarotensis hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 XP_022629746.1 421326 R 1245769 CDS LALA0_S08e04654g 34687043 complement(425381..426637) Unknown 1 NW_019212886.1 similar to uniprot|P38911 Saccharomyces cerevisiae YML074C (ohnolog of YLR449W) FPR3 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; peptidylprolyl isomerase FPR3 426637 34687043 LALA0_S08e04654g Lachancea lanzarotensis peptidylprolyl isomerase FPR3 XP_022629747.1 425381 R 1245769 CDS LALA0_S08e04698g 34687045 427342..428523 Unknown 1 NW_019212886.1 highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C OLA1 P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide; Obg-like ATPase 428523 34687045 LALA0_S08e04698g Lachancea lanzarotensis Obg-like ATPase XP_022629748.1 427342 D 1245769 CDS LALA0_S08e04720g 34687046 complement(428702..429616) Unknown 1 NW_019212886.1 similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C (ohnolog of YBR024W) SCO1 Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins; uncharacterized protein 429616 34687046 LALA0_S08e04720g Lachancea lanzarotensis uncharacterized protein XP_022629749.1 428702 R 1245769 CDS LALA0_S08e04742g 34687047 431001..433787 Unknown 1 NW_019212886.1 similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; chitin synthase CHS2 433787 34687047 LALA0_S08e04742g Lachancea lanzarotensis chitin synthase CHS2 XP_022629750.1 431001 D 1245769 CDS LALA0_S08e04764g 34687048 complement(433844..435211) Unknown 1 NW_019212886.1 highly similar to Lachancea thermotolerans KLTH0A01848g hypothetical protein; uncharacterized protein 435211 34687048 LALA0_S08e04764g Lachancea lanzarotensis uncharacterized protein XP_022629751.1 433844 R 1245769 CDS LALA0_S08e04786g 34687049 437812..441057 Unknown 1 NW_019212886.1 similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; chitin synthase CHS3 441057 34687049 LALA0_S08e04786g Lachancea lanzarotensis chitin synthase CHS3 XP_022629752.1 437812 D 1245769 CDS LALA0_S08e04808g 34687050 complement(441240..441794) Unknown 1 NW_019212886.1 similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing; ADP-ribose 1''-phosphate phosphatase 441794 34687050 LALA0_S08e04808g Lachancea lanzarotensis ADP-ribose 1''-phosphate phosphatase XP_022629753.1 441240 R 1245769 CDS LALA0_S08e04830g 34687051 complement(442072..446562) Unknown 1 NW_019212886.1 similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; ATP-binding cassette transporter SNQ2 446562 34687051 LALA0_S08e04830g Lachancea lanzarotensis ATP-binding cassette transporter SNQ2 XP_022629754.1 442072 R 1245769 CDS LALA0_S08e04852g 34687052 complement(447989..449575) Unknown 1 NW_019212886.1 similar to uniprot|P13045 Saccharomyces cerevisiae YDR009W (ohnolog of YBR020W) GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; galactokinase 449575 34687052 LALA0_S08e04852g Lachancea lanzarotensis galactokinase XP_022629755.1 447989 R 1245769 CDS LALA0_S08e04874g 34687053 join(450270..450656,450656..450781) Unknown 1 NW_019212886.1 some similarities with uniprot|C5DBG4 Lachancea thermotolerans KLTH0A02398g hypothetical protein; 450781 34687053 LALA0_S08e04874g Lachancea lanzarotensis 450270 D 1245769 CDS LALA0_S08e04918g 34687055 complement(452305..453861) Unknown 1 NW_019212886.1 similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene; uncharacterized protein 453861 34687055 LALA0_S08e04918g Lachancea lanzarotensis uncharacterized protein XP_022629756.1 452305 R 1245769 CDS LALA0_S08e04940g 34687056 454037..455401 Unknown 1 NW_019212886.1 similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle; mRNA splicing protein SAD1 455401 34687056 LALA0_S08e04940g Lachancea lanzarotensis mRNA splicing protein SAD1 XP_022629757.1 454037 D 1245769 CDS LALA0_S08e04962g 34687057 complement(455484..456422) Unknown 1 NW_019212886.1 highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; proteasome regulatory particle lid subunit RPN11 456422 34687057 LALA0_S08e04962g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN11 XP_022629758.1 455484 R 1245769 CDS LALA0_S08e04984g 34687058 456744..457232 Unknown 1 NW_019212886.1 similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen; type 1 protein phosphatase-activating protein YPI1 457232 34687058 LALA0_S08e04984g Lachancea lanzarotensis type 1 protein phosphatase-activating protein YPI1 XP_022629759.1 456744 D 1245769 CDS LALA0_S08e05006g 34687059 complement(457381..459924) Unknown 1 NW_019212886.1 similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p; linker nucleoporin NIC96 459924 34687059 LALA0_S08e05006g Lachancea lanzarotensis linker nucleoporin NIC96 XP_022629760.1 457381 R 1245769 CDS LALA0_S08e05028g 34687060 complement(460346..460966) Unknown 1 NW_019212886.1 similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; uncharacterized protein 460966 34687060 LALA0_S08e05028g Lachancea lanzarotensis uncharacterized protein XP_022629761.1 460346 R 1245769 CDS LALA0_S08e05138g 34687061 complement(461491..462666) Unknown 1 NW_019212886.1 similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair; histone acetyltransferase catalytic subunit HAT1 462666 34687061 LALA0_S08e05138g Lachancea lanzarotensis histone acetyltransferase catalytic subunit HAT1 XP_022629762.1 461491 R 1245769 CDS LALA0_S08e05160g 34687062 462857..463561 Unknown 1 NW_019212886.1 similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression; ESCRT-II subunit protein SNF8 463561 34687062 LALA0_S08e05160g Lachancea lanzarotensis ESCRT-II subunit protein SNF8 XP_022629763.1 462857 D 1245769 CDS LALA0_S08e05182g 34687063 complement(463591..464907) Unknown 1 NW_019212886.1 similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability; uncharacterized protein 464907 34687063 LALA0_S08e05182g Lachancea lanzarotensis uncharacterized protein XP_022629764.1 463591 R 1245769 CDS LALA0_S08e05204g 34687064 465100..466896 Unknown 1 NW_019212886.1 similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients; uncharacterized protein 466896 34687064 LALA0_S08e05204g Lachancea lanzarotensis uncharacterized protein XP_022629765.1 465100 D 1245769 CDS LALA0_S08e05226g 34687065 complement(466918..468216) Unknown 1 NW_019212886.1 weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; uncharacterized protein 468216 34687065 LALA0_S08e05226g Lachancea lanzarotensis uncharacterized protein XP_022629766.1 466918 R 1245769 CDS LALA0_S08e05248g 34687066 469521..470471 Unknown 1 NW_019212886.1 highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family; lipid-binding protein LSP1 470471 34687066 LALA0_S08e05248g Lachancea lanzarotensis lipid-binding protein LSP1 XP_022629767.1 469521 D 1245769 CDS LALA0_S08e05270g 34687067 complement(471322..473118) Unknown 1 NW_019212886.1 similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA; uncharacterized protein 473118 34687067 LALA0_S08e05270g Lachancea lanzarotensis uncharacterized protein XP_022629768.1 471322 R 1245769 CDS LALA0_S08e05292g 34687068 complement(473377..476907) Unknown 1 NW_019212886.1 similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein; sphingolipid transporter 476907 34687068 LALA0_S08e05292g Lachancea lanzarotensis sphingolipid transporter XP_022629769.1 473377 R 1245769 CDS LALA0_S08e05314g 34687069 477588..479306 Unknown 1 NW_019212886.1 similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90; transcription factor TFIIIC subunit TFC8 479306 34687069 LALA0_S08e05314g Lachancea lanzarotensis transcription factor TFIIIC subunit TFC8 XP_022629770.1 477588 D 1245769 CDS LALA0_S08e05336g 34687070 complement(479356..481830) Unknown 1 NW_019212886.1 similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W CHL1 Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; DNA helicase 481830 34687070 LALA0_S08e05336g Lachancea lanzarotensis DNA helicase XP_022629771.1 479356 R 1245769 CDS LALA0_S08e05358g 34687071 482093..483103 Unknown 1 NW_019212886.1 similar to uniprot|C5DBG4 Lachancea thermotolerans KLTH0A02398g hypothetical protein; uncharacterized protein 483103 34687071 LALA0_S08e05358g Lachancea lanzarotensis uncharacterized protein XP_022629772.1 482093 D 1245769 CDS LALA0_S08e05380g 34687072 483113..483268 Unknown 1 NW_019212886.1 hypothetical protein; uncharacterized protein 483268 34687072 LALA0_S08e05380g Lachancea lanzarotensis uncharacterized protein XP_022629773.1 483113 D 1245769 CDS LALA0_S08e05402g 34687073 484028..485089 Unknown 1 NW_019212886.1 weakly similar to uniprot|Q02606 Saccharomyces cerevisiae YPL014W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; uncharacterized protein 485089 34687073 LALA0_S08e05402g Lachancea lanzarotensis uncharacterized protein XP_022629774.1 484028 D 1245769 CDS LALA0_S08e05424g 34687074 complement(485470..485829) Unknown 1 NW_019212886.1 similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein bS16m 485829 34687074 LALA0_S08e05424g Lachancea lanzarotensis mitochondrial 37S ribosomal protein bS16m XP_022629775.1 485470 R 1245769 CDS LALA0_S08e05446g 34687075 486100..489765 Unknown 1 NW_019212886.1 similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats; mRNA-binding protein RRP12 489765 34687075 LALA0_S08e05446g Lachancea lanzarotensis mRNA-binding protein RRP12 XP_022629776.1 486100 D 1245769 CDS LALA0_S08e05468g 34687076 complement(489956..491011) Unknown 1 NW_019212886.1 similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation; uncharacterized protein 491011 34687076 LALA0_S08e05468g Lachancea lanzarotensis uncharacterized protein XP_022629777.1 489956 R 1245769 CDS LALA0_S08e05490g 34687077 491325..491897 Unknown 1 NW_019212886.1 similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; coatomer subunit zeta 491897 34687077 LALA0_S08e05490g Lachancea lanzarotensis coatomer subunit zeta XP_022629778.1 491325 D 1245769 CDS LALA0_S08e05512g 34687078 complement(492055..495264) Unknown 1 NW_019212886.1 similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C TAE2 Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 495264 34687078 LALA0_S08e05512g Lachancea lanzarotensis uncharacterized protein XP_022629779.1 492055 R 1245769 CDS LALA0_S08e05556g 34687080 497573..498706 Unknown 1 NW_019212886.1 similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; histone deacetylase HST2 498706 34687080 LALA0_S08e05556g Lachancea lanzarotensis histone deacetylase HST2 XP_022629780.1 497573 D 1245769 CDS LALA0_S08e05578g 34687081 complement(499008..500744) Unknown 1 NW_019212886.1 similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions; SUMO protease ULP1 500744 34687081 LALA0_S08e05578g Lachancea lanzarotensis SUMO protease ULP1 XP_022629781.1 499008 R 1245769 CDS LALA0_S08e05600g 34687082 complement(502018..502677) Unknown 1 NW_019212886.1 similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm; uncharacterized protein 502677 34687082 LALA0_S08e05600g Lachancea lanzarotensis uncharacterized protein XP_022629782.1 502018 R 1245769 CDS LALA0_S08e05622g 34687083 complement(502851..504140) Unknown 1 NW_019212886.1 similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; tRNA dihydrouridine synthase 504140 34687083 LALA0_S08e05622g Lachancea lanzarotensis tRNA dihydrouridine synthase XP_022629783.1 502851 R 1245769 CDS LALA0_S08e05644g 34687084 complement(504424..508002) Unknown 1 NW_019212886.1 similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W (ohnolog of YJR127C) TDA9 DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; uncharacterized protein 508002 34687084 LALA0_S08e05644g Lachancea lanzarotensis uncharacterized protein XP_022629784.1 504424 R 1245769 CDS LALA0_S08e05666g 34687085 complement(510042..510287) Unknown 1 NW_019212886.1 similar to uniprot|C5DGC9 Lachancea thermotolerans KLTH0D04290g hypothetical protein; uncharacterized protein 510287 34687085 LALA0_S08e05666g Lachancea lanzarotensis uncharacterized protein XP_022629785.1 510042 R 1245769 CDS LALA0_S08e05688g 34687086 complement(511370..512320) Unknown 1 NW_019212886.1 similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein-lysine N-methyltransferase 512320 34687086 LALA0_S08e05688g Lachancea lanzarotensis protein-lysine N-methyltransferase XP_022629786.1 511370 R 1245769 CDS LALA0_S08e05710g 34687087 complement(512445..513497) Unknown 1 NW_019212886.1 similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; allantoicase 513497 34687087 LALA0_S08e05710g Lachancea lanzarotensis allantoicase XP_022629787.1 512445 R 1245769 CDS LALA0_S08e05732g 34687088 514931..516511 Unknown 1 NW_019212886.1 similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C HFD1 Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome; hexadecenal dehydrogenase 516511 34687088 LALA0_S08e05732g Lachancea lanzarotensis hexadecenal dehydrogenase XP_022629788.1 514931 D 1245769 CDS LALA0_S08e05754g 34687089 complement(516636..520382) Unknown 1 NW_019212886.1 highly similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W (ohnolog of YKL129C) MYO5 One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; uncharacterized protein 520382 34687089 LALA0_S08e05754g Lachancea lanzarotensis uncharacterized protein XP_022629789.1 516636 R 1245769 CDS LALA0_S08e05776g 34687090 complement(520807..522867) Unknown 1 NW_019212886.1 highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control; acetolactate synthase catalytic subunit 522867 34687090 LALA0_S08e05776g Lachancea lanzarotensis acetolactate synthase catalytic subunit XP_022629790.1 520807 R 1245769 CDS LALA0_S08e05798g 34687091 complement(524277..524600) Unknown 1 NW_019212886.1 similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; uncharacterized protein 524600 34687091 LALA0_S08e05798g Lachancea lanzarotensis uncharacterized protein XP_022629791.1 524277 R 1245769 CDS LALA0_S08e05820g 34687092 complement(join(525138..525560,525842..526378)) Unknown 1 NW_019212886.1 highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation; 40S ribosomal protein RACK1 526378 34687092 LALA0_S08e05820g Lachancea lanzarotensis 40S ribosomal protein RACK1 XP_022629792.1 525138 R 1245769 CDS LALA0_S08e05842g 34687093 528519..530660 Unknown 1 NW_019212886.1 similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; uncharacterized protein 530660 34687093 LALA0_S08e05842g Lachancea lanzarotensis uncharacterized protein XP_022629793.1 528519 D 1245769 CDS LALA0_S08e05864g 34687094 complement(530778..531110) Unknown 1 NW_019212886.1 similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W CMC1 Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif; uncharacterized protein 531110 34687094 LALA0_S08e05864g Lachancea lanzarotensis uncharacterized protein XP_022629794.1 530778 R 1245769 CDS LALA0_S08e05886g 34687095 531397..531792 Unknown 1 NW_019212886.1 similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL60 531792 34687095 LALA0_S08e05886g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL60 XP_022629795.1 531397 D 1245769 CDS LALA0_S08e05908g 34687096 complement(531947..532552) Unknown 1 NW_019212886.1 similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; kinetochore-associated Ndc80 complex subunit SPC24 532552 34687096 LALA0_S08e05908g Lachancea lanzarotensis kinetochore-associated Ndc80 complex subunit SPC24 XP_022629796.1 531947 R 1245769 CDS LALA0_S08e05930g 34687097 532730..532945 Unknown 1 NW_019212886.1 similar to uniprot|P69852 Saccharomyces cerevisiae YKL138C-A HSK3 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 532945 34687097 LALA0_S08e05930g Lachancea lanzarotensis uncharacterized protein XP_022629797.1 532730 D 1245769 CDS LALA0_S08e05952g 34687098 complement(join(533143..534554,534625..534637)) Unknown 1 NW_019212886.1 similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13; cyclin-dependent serine/threonine protein kinase CTK1 534637 34687098 LALA0_S08e05952g Lachancea lanzarotensis cyclin-dependent serine/threonine protein kinase CTK1 XP_022629798.1 533143 R 1245769 CDS LALA0_S08e05974g 34687099 complement(534912..536297) Unknown 1 NW_019212886.1 similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; sterol esterase 536297 34687099 LALA0_S08e05974g Lachancea lanzarotensis sterol esterase XP_022629799.1 534912 R 1245769 CDS LALA0_S08e05996g 34687100 complement(538154..538660) Unknown 1 NW_019212886.1 similar to uniprot|Q04487 Saccharomyces cerevisiae YMR118C (ohnolog of YKL141W) Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene; succinate dehydrogenase cytochrome b subunit SDH3 538660 34687100 LALA0_S08e05996g Lachancea lanzarotensis succinate dehydrogenase cytochrome b subunit SDH3 XP_022629800.1 538154 R 1245769 CDS LALA0_S08e06018g 34687101 complement(539401..540021) Unknown 1 NW_019212886.1 similar to uniprot|C5DGB7 Lachancea thermotolerans KLTH0D04004g hypothetical protein; uncharacterized protein 540021 34687101 LALA0_S08e06018g Lachancea lanzarotensis uncharacterized protein XP_022629801.1 539401 R 1245769 CDS LALA0_S08e06040g 34687102 541811..542497 Unknown 1 NW_019212886.1 similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III subunit protein SNF7 542497 34687102 LALA0_S08e06040g Lachancea lanzarotensis ESCRT-III subunit protein SNF7 XP_022629802.1 541811 D 1245769 CDS LALA0_S08e06062g 34687103 complement(542737..543621) Unknown 1 NW_019212886.1 similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; t-SNARE syntaxin 543621 34687103 LALA0_S08e06062g Lachancea lanzarotensis t-SNARE syntaxin XP_022629803.1 542737 R 1245769 CDS LALA0_S08e06084g 34687104 545531..547321 Unknown 1 NW_019212886.1 weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 547321 34687104 LALA0_S08e06084g Lachancea lanzarotensis uncharacterized protein XP_022629804.1 545531 D 1245769 CDS LALA0_S08e06106g 34687105 complement(547394..548656) Unknown 1 NW_019212886.1 highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; aspartate transaminase AAT2 548656 34687105 LALA0_S08e06106g Lachancea lanzarotensis aspartate transaminase AAT2 XP_022629805.1 547394 R 1245769 CDS LALA0_S08e06150g 34687107 complement(550092..551282) Unknown 1 NW_019212886.1 similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64; cleavage polyadenylation factor subunit PTI1 551282 34687107 LALA0_S08e06150g Lachancea lanzarotensis cleavage polyadenylation factor subunit PTI1 XP_022629806.1 550092 R 1245769 CDS LALA0_S08e06172g 34687108 complement(552001..552801) Unknown 1 NW_019212886.1 similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; uncharacterized protein 552801 34687108 LALA0_S08e06172g Lachancea lanzarotensis uncharacterized protein XP_022629807.1 552001 R 1245769 CDS LALA0_S08e06194g 34687109 553111..554016 Unknown 1 NW_019212886.1 similar to uniprot|P07273 Saccharomyces cerevisiae YGL043W DST1 General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; transcription elongation factor DST1 554016 34687109 LALA0_S08e06194g Lachancea lanzarotensis transcription elongation factor DST1 XP_022629808.1 553111 D 1245769 CDS LALA0_S08e06216g 34687110 554277..554705 Unknown 1 NW_019212886.1 similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry; uncharacterized protein 554705 34687110 LALA0_S08e06216g Lachancea lanzarotensis uncharacterized protein XP_022629809.1 554277 D 1245769 CDS LALA0_S08e06238g 34687111 complement(554780..556270) Unknown 1 NW_019212886.1 highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria; cystathionine beta-synthase CYS4 556270 34687111 LALA0_S08e06238g Lachancea lanzarotensis cystathionine beta-synthase CYS4 XP_022629810.1 554780 R 1245769 CDS LALA0_S08e06260g 34687112 558117..558791 Unknown 1 NW_019212886.1 similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes; ESCRT-III subunit protein VPS20 558791 34687112 LALA0_S08e06260g Lachancea lanzarotensis ESCRT-III subunit protein VPS20 XP_022629811.1 558117 D 1245769 CDS LALA0_S08e06282g 34687113 complement(558923..559945) Unknown 1 NW_019212886.1 highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; porphobilinogen synthase HEM2 559945 34687113 LALA0_S08e06282g Lachancea lanzarotensis porphobilinogen synthase HEM2 XP_022629812.1 558923 R 1245769 CDS LALA0_S08e06304g 34687114 560139..560879 Unknown 1 NW_019212886.1 similar to uniprot|C5DGB7 Lachancea thermotolerans KLTH0D04004g hypothetical protein; uncharacterized protein 560879 34687114 LALA0_S08e06304g Lachancea lanzarotensis uncharacterized protein XP_022629813.1 560139 D 1245769 CDS LALA0_S08e06326g 34687115 562156..564696 Unknown 1 NW_019212886.1 similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis; phosphatidylethanolamine N-methyltransferase 564696 34687115 LALA0_S08e06326g Lachancea lanzarotensis phosphatidylethanolamine N-methyltransferase XP_022629814.1 562156 D 1245769 CDS LALA0_S08e06348g 34687116 complement(564878..565624) Unknown 1 NW_019212886.1 similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6); exosome non-catalytic core subunit MTR3 565624 34687116 LALA0_S08e06348g Lachancea lanzarotensis exosome non-catalytic core subunit MTR3 XP_022629815.1 564878 R 1245769 CDS LALA0_S08e06370g 34687117 complement(565840..567528) Unknown 1 NW_019212886.1 similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family; uncharacterized protein 567528 34687117 LALA0_S08e06370g Lachancea lanzarotensis uncharacterized protein XP_022629816.1 565840 R 1245769 CDS LALA0_S08e06392g 34687118 complement(568683..570089) Unknown 1 NW_019212886.1 similar to uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis; uncharacterized protein 570089 34687118 LALA0_S08e06392g Lachancea lanzarotensis uncharacterized protein XP_022629817.1 568683 R 1245769 CDS LALA0_S08e06414g 34687119 complement(570696..572972) Unknown 1 NW_019212886.1 hypothetical protein; uncharacterized protein 572972 34687119 LALA0_S08e06414g Lachancea lanzarotensis uncharacterized protein XP_022629818.1 570696 R 1245769 CDS LALA0_S08e06436g 34687120 complement(573874..574938) Unknown 1 NW_019212886.1 similar to uniprot|C5DG83 Lachancea thermotolerans KLTH0D03146g hypothetical protein; uncharacterized protein 574938 34687120 LALA0_S08e06436g Lachancea lanzarotensis uncharacterized protein XP_022629819.1 573874 R 1245769 CDS LALA0_S08e06458g 34687121 complement(576079..576687) Unknown 1 NW_019212886.1 similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W ALG13 Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 576687 34687121 LALA0_S08e06458g Lachancea lanzarotensis N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 XP_022629820.1 576079 R 1245769 CDS LALA0_S08e06480g 34687122 576933..578147 Unknown 1 NW_019212886.1 highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; proteasome regulatory particle base subunit RPT6 578147 34687122 LALA0_S08e06480g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT6 XP_022629821.1 576933 D 1245769 CDS LALA0_S08e06502g 34687123 580773..583763 Unknown 1 NW_019212886.1 similar to uniprot|P39935 Saccharomyces cerevisiae YGR162W (ohnolog of YGL049C) TIF4631 Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; uncharacterized protein 583763 34687123 LALA0_S08e06502g Lachancea lanzarotensis uncharacterized protein XP_022629822.1 580773 D 1245769 CDS LALA0_S08e06524g 34687124 complement(584124..584912) Unknown 1 NW_019212886.1 similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W TYW3 tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; tRNA methyltransferase TYW3 584912 34687124 LALA0_S08e06524g Lachancea lanzarotensis tRNA methyltransferase TYW3 XP_022629823.1 584124 R 1245769 CDS LALA0_S08e06546g 34687125 join(585854..585912,586011..586980) Unknown 1 NW_019212886.1 highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD; uncharacterized protein 586980 34687125 LALA0_S08e06546g Lachancea lanzarotensis uncharacterized protein XP_022629824.1 585854 D 1245769 CDS LALA0_S08e06568g 34687126 587639..589756 Unknown 1 NW_019212886.1 weakly similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion; uncharacterized protein 589756 34687126 LALA0_S08e06568g Lachancea lanzarotensis uncharacterized protein XP_022629825.1 587639 D 1245769 CDS LALA0_S08e06634g 34687129 591954..593285 Unknown 1 NW_019212886.1 highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis; bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 593285 34687129 LALA0_S08e06634g Lachancea lanzarotensis bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 XP_022629826.1 591954 D 1245769 CDS LALA0_S08e06656g 34687130 complement(593432..598039) Unknown 1 NW_019212886.1 similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p; ATP-binding cassette bilirubin transporter BPT1 598039 34687130 LALA0_S08e06656g Lachancea lanzarotensis ATP-binding cassette bilirubin transporter BPT1 XP_022629827.1 593432 R 1245769 CDS LALA0_S08e06678g 34687131 complement(598426..600759) Unknown 1 NW_019212886.1 highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; aconitate hydratase ACO1 600759 34687131 LALA0_S08e06678g Lachancea lanzarotensis aconitate hydratase ACO1 XP_022629828.1 598426 R 1245769 CDS LALA0_S08e06700g 34687132 complement(join(601291..606937,606999..607012)) Unknown 1 NW_019212886.1 similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; 1-phosphatidylinositol 4-kinase STT4 607012 34687132 LALA0_S08e06700g Lachancea lanzarotensis 1-phosphatidylinositol 4-kinase STT4 XP_022629829.1 601291 R 1245769 CDS LALA0_S08e06722g 34687133 complement(607387..608340) Unknown 1 NW_019212886.1 weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C NTR2 Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly; uncharacterized protein 608340 34687133 LALA0_S08e06722g Lachancea lanzarotensis uncharacterized protein XP_022629830.1 607387 R 1245769 CDS LALA0_S08e06744g 34687134 complement(608560..611151) Unknown 1 NW_019212886.1 weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus; uncharacterized protein 611151 34687134 LALA0_S08e06744g Lachancea lanzarotensis uncharacterized protein XP_022629831.1 608560 R 1245769 CDS LALA0_S08e06766g 34687135 612727..614901 Unknown 1 NW_019212886.1 similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; protein kinase activating protein DPB11 614901 34687135 LALA0_S08e06766g Lachancea lanzarotensis protein kinase activating protein DPB11 XP_022629832.1 612727 D 1245769 CDS LALA0_S08e06788g 34687136 615118..616590 Unknown 1 NW_019212886.1 similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; glucosaminyl-phosphotidylinositol O-acyltransferase 616590 34687136 LALA0_S08e06788g Lachancea lanzarotensis glucosaminyl-phosphotidylinositol O-acyltransferase XP_022629833.1 615118 D 1245769 CDS LALA0_S08e06810g 34687137 complement(616625..619876) Unknown 1 NW_019212886.1 similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W SRS2 DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability; DNA helicase SRS2 619876 34687137 LALA0_S08e06810g Lachancea lanzarotensis DNA helicase SRS2 XP_022629834.1 616625 R 1245769 CDS LALA0_S08e06832g 34687138 621206..622984 Unknown 1 NW_019212886.1 similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin; uncharacterized protein 622984 34687138 LALA0_S08e06832g Lachancea lanzarotensis uncharacterized protein XP_022629835.1 621206 D 1245769 CDS LALA0_S08e06854g 34687139 complement(623072..627469) Unknown 1 NW_019212886.1 similar to uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; mitogen-activated protein kinase kinase kinase BCK1 627469 34687139 LALA0_S08e06854g Lachancea lanzarotensis mitogen-activated protein kinase kinase kinase BCK1 XP_022629836.1 623072 R 1245769 CDS LALA0_S08e06876g 34687140 complement(627854..628357) Unknown 1 NW_019212886.1 similar to uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL21m 628357 34687140 LALA0_S08e06876g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL21m XP_022629837.1 627854 R 1245769 CDS LALA0_S08e06898g 34687141 complement(628677..629324) Unknown 1 NW_019212886.1 similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W PHS1 Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking; enoyl-CoA hydratase PHS1 629324 34687141 LALA0_S08e06898g Lachancea lanzarotensis enoyl-CoA hydratase PHS1 XP_022629838.1 628677 R 1245769 CDS LALA0_S08e06920g 34687142 complement(630003..633302) Unknown 1 NW_019212886.1 similar to uniprot|P40856 Saccharomyces cerevisiae YJL098W (ohnolog of YKR028W) SAP185 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; uncharacterized protein 633302 34687142 LALA0_S08e06920g Lachancea lanzarotensis uncharacterized protein XP_022629839.1 630003 R 1245769 CDS LALA0_S08e06942g 34687143 complement(633723..635942) Unknown 1 NW_019212886.1 similar to uniprot|P40955 Saccharomyces cerevisiae YJL099W (ohnolog of YKR027W) CHS6 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; uncharacterized protein 635942 34687143 LALA0_S08e06942g Lachancea lanzarotensis uncharacterized protein XP_022629840.1 633723 R 1245769 CDS LALA0_S08e06964g 34687144 complement(636143..637735) Unknown 1 NW_019212886.1 similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; 1-phosphatidylinositol 4-kinase LSB6 637735 34687144 LALA0_S08e06964g Lachancea lanzarotensis 1-phosphatidylinositol 4-kinase LSB6 XP_022629841.1 636143 R 1245769 CDS LALA0_S08e06986g 34687145 640994..642958 Unknown 1 NW_019212886.1 similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; glutamate--cysteine ligase 642958 34687145 LALA0_S08e06986g Lachancea lanzarotensis glutamate--cysteine ligase XP_022629842.1 640994 D 1245769 CDS LALA0_S08e07030g 34687147 complement(643393..645789) Unknown 1 NW_019212886.1 similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 Mitochondrial elongation factor involved in translational elongation; uncharacterized protein 645789 34687147 LALA0_S08e07030g Lachancea lanzarotensis uncharacterized protein XP_022629843.1 643393 R 1245769 CDS LALA0_S08e07052g 34687148 646002..646919 Unknown 1 NW_019212886.1 highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression; translation initiation factor eIF2B subunit alpha 646919 34687148 LALA0_S08e07052g Lachancea lanzarotensis translation initiation factor eIF2B subunit alpha XP_022629844.1 646002 D 1245769 CDS LALA0_S08e07074g 34687149 complement(646962..647729) Unknown 1 NW_019212886.1 similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37; DNA-directed RNA polymerase III subunit C37 647729 34687149 LALA0_S08e07074g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit C37 XP_022629845.1 646962 R 1245769 CDS LALA0_S08e07096g 34687150 647905..650061 Unknown 1 NW_019212886.1 similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions; uncharacterized protein 650061 34687150 LALA0_S08e07096g Lachancea lanzarotensis uncharacterized protein XP_022629846.1 647905 D 1245769 CDS LALA0_S08e07118g 34687151 complement(650411..651949) Unknown 1 NW_019212886.1 similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 651949 34687151 LALA0_S08e07118g Lachancea lanzarotensis uncharacterized protein XP_022629847.1 650411 R 1245769 CDS LALA0_S08e07140g 34687152 652185..653540 Unknown 1 NW_019212886.1 similar to uniprot|Q6CLI0 Kluyveromyces lactis hypothetical protein; uncharacterized protein 653540 34687152 LALA0_S08e07140g Lachancea lanzarotensis uncharacterized protein XP_022629848.1 652185 D 1245769 CDS LALA0_S08e07162g 34687153 complement(654584..654994) Unknown 1 NW_019212886.1 similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W PAM16 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain; import motor complex subunit PAM16 654994 34687153 LALA0_S08e07162g Lachancea lanzarotensis import motor complex subunit PAM16 XP_022629849.1 654584 R 1245769 CDS LALA0_S08e07184g 34687154 complement(655247..657475) Unknown 1 NW_019212886.1 similar to uniprot|P42948 Saccharomyces cerevisiae YJL105W (ohnolog of YKR029C) SET4 Protein of unknown function, contains a SET domain; uncharacterized protein 657475 34687154 LALA0_S08e07184g Lachancea lanzarotensis uncharacterized protein XP_022629850.1 655247 R 1245769 CDS LALA0_S08e07206g 34687155 complement(658362..659636) Unknown 1 NW_019212886.1 similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein; uncharacterized protein 659636 34687155 LALA0_S08e07206g Lachancea lanzarotensis uncharacterized protein XP_022629851.1 658362 R 1245769 CDS LALA0_S08e07228g 34687156 complement(659886..661868) Unknown 1 NW_019212886.1 similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; protein kinase IME2 661868 34687156 LALA0_S08e07228g Lachancea lanzarotensis protein kinase IME2 XP_022629852.1 659886 R 1245769 CDS LALA0_S08e07250g 34687157 664999..665643 Unknown 1 NW_019212886.1 weakly similar to uniprot|C5DNK5 Lachancea thermotolerans KLTH0G17798g hypothetical protein; uncharacterized protein 665643 34687157 LALA0_S08e07250g Lachancea lanzarotensis uncharacterized protein XP_022629853.1 664999 D 1245769 CDS LALA0_S08e07272g 34687158 666653..667297 Unknown 1 NW_019212886.1 weakly similar to uniprot|P25354 Saccharomyces cerevisiae YCR007C Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene; uncharacterized protein 667297 34687158 LALA0_S08e07272g Lachancea lanzarotensis uncharacterized protein XP_022629854.1 666653 D 1245769 CDS LALA0_S08e07294g 34687159 668231..669094 Unknown 1 NW_019212886.1 highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome; proteasome core particle subunit beta 5 669094 34687159 LALA0_S08e07294g Lachancea lanzarotensis proteasome core particle subunit beta 5 XP_022629855.1 668231 D 1245769 CDS LALA0_S08e07316g 34687160 complement(669204..671837) Unknown 1 NW_019212886.1 similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C FHL1 Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants; uncharacterized protein 671837 34687160 LALA0_S08e07316g Lachancea lanzarotensis uncharacterized protein XP_022629856.1 669204 R 1245769 CDS LALA0_S08e07338g 34687161 complement(672407..674857) Unknown 1 NW_019212886.1 similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG4 674857 34687161 LALA0_S08e07338g Lachancea lanzarotensis Golgi transport complex subunit COG4 XP_022629857.1 672407 R 1245769 CDS LALA0_S08e07360g 34687162 complement(675631..676569) Unknown 1 NW_019212886.1 highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; uncharacterized protein 676569 34687162 LALA0_S08e07360g Lachancea lanzarotensis uncharacterized protein XP_022629858.1 675631 R 1245769 CDS LALA0_S08e07382g 34687163 680379..681575 Unknown 1 NW_019212886.1 weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 681575 34687163 LALA0_S08e07382g Lachancea lanzarotensis uncharacterized protein XP_022629859.1 680379 D 1245769 CDS LALA0_S08e07404g 34687164 complement(682364..682702) Unknown 1 NW_019212886.1 some similarities with uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; uncharacterized protein 682702 34687164 LALA0_S08e07404g Lachancea lanzarotensis uncharacterized protein XP_022629860.1 682364 R 1245769 CDS LALA0_S08e07426g 34687165 683553..684680 Unknown 1 NW_019212886.1 weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; uncharacterized protein 684680 34687165 LALA0_S08e07426g Lachancea lanzarotensis uncharacterized protein XP_022629861.1 683553 D 1245769 CDS LALA0_S08e07448g 34687166 complement(685259..685891) Unknown 1 NW_019212886.1 highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; uncharacterized protein 685891 34687166 LALA0_S08e07448g Lachancea lanzarotensis uncharacterized protein XP_022629862.1 685259 R 1245769 CDS LALA0_S08e07470g 34687167 complement(686526..687116) Unknown 1 NW_019212886.1 weakly similar to uniprot|P18411 Saccharomyces cerevisiae YAL008W FUN14 Mitochondrial protein of unknown function; uncharacterized protein 687116 34687167 LALA0_S08e07470g Lachancea lanzarotensis uncharacterized protein XP_022629863.1 686526 R 1245769 CDS LALA0_S08e07492g 34687168 complement(join(687605..689626,689743..689763)) Unknown 1 NW_019212886.1 similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p; homolog of the mammalian B' subunit of PP2A; protein phosphatase 2A regulatory subunit RTS1 689763 34687168 LALA0_S08e07492g Lachancea lanzarotensis protein phosphatase 2A regulatory subunit RTS1 XP_022629864.1 687605 R 1245769 CDS LALA0_S08e07514g 34687169 complement(690133..691122) Unknown 1 NW_019212886.1 similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation; Nem1-Spo7 phosphatase regulatory subunit SPO7 691122 34687169 LALA0_S08e07514g Lachancea lanzarotensis Nem1-Spo7 phosphatase regulatory subunit SPO7 XP_022629865.1 690133 R 1245769 CDS LALA0_S08e07536g 34687170 691550..692869 Unknown 1 NW_019212886.1 similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins; uncharacterized protein 692869 34687170 LALA0_S08e07536g Lachancea lanzarotensis uncharacterized protein XP_022629866.1 691550 D 1245769 CDS LALA0_S08e07558g 34687171 complement(692964..694763) Unknown 1 NW_019212886.1 similar to uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; uncharacterized protein 694763 34687171 LALA0_S08e07558g Lachancea lanzarotensis uncharacterized protein XP_022629867.1 692964 R 1245769 CDS LALA0_S08e07580g 34687172 695401..698679 Unknown 1 NW_019212886.1 similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; DNA repair ATPase SMC5 698679 34687172 LALA0_S08e07580g Lachancea lanzarotensis DNA repair ATPase SMC5 XP_022629868.1 695401 D 1245769 CDS LALA0_S08e07602g 34687173 699008..700714 Unknown 1 NW_019212886.1 similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated; 700714 34687173 LALA0_S08e07602g Lachancea lanzarotensis 699008 D 1245769 CDS LALA0_S08e07624g 34687174 700970..701674 Unknown 1 NW_019212886.1 similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W OPI10 Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline; uncharacterized protein 701674 34687174 LALA0_S08e07624g Lachancea lanzarotensis uncharacterized protein XP_022629869.1 700970 D 1245769 CDS LALA0_S08e07646g 34687175 complement(701770..702954) Unknown 1 NW_019212886.1 similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein; uncharacterized protein 702954 34687175 LALA0_S08e07646g Lachancea lanzarotensis uncharacterized protein XP_022629870.1 701770 R 1245769 CDS LALA0_S08e07668g 34687176 complement(703156..704331) Unknown 1 NW_019212886.1 highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; cystathionine gamma-lyase CYS3 704331 34687176 LALA0_S08e07668g Lachancea lanzarotensis cystathionine gamma-lyase CYS3 XP_022629871.1 703156 R 1245769 CDS LALA0_S08e07690g 34687177 708168..709175 Unknown 1 NW_019212886.1 highly similar to uniprot|P53228 Saccharomyces cerevisiae YGR043C (ohnolog of YLR354C) NQM1 Transaldolaseof unknown function; transcription is repressed by Mot1pand induced by alpha-factor and during diauxic shift; sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase TAL1 709175 34687177 LALA0_S08e07690g Lachancea lanzarotensis sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase TAL1 XP_022629872.1 708168 D 1245769 CDS LALA0_S08e07712g 34687178 complement(709358..710260) Unknown 1 NW_019212886.1 weakly similar to uniprot|P53227 Saccharomyces cerevisiae YGR042W Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 710260 34687178 LALA0_S08e07712g Lachancea lanzarotensis uncharacterized protein XP_022629873.1 709358 R 1245769 CDS LALA0_S08e07734g 34687179 complement(710805..712394) Unknown 1 NW_019212886.1 weakly similar to uniprot|P53226 Saccharomyces cerevisiae YGR041W (ohnolog of YLR353W) BUD9 Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; uncharacterized protein 712394 34687179 LALA0_S08e07734g Lachancea lanzarotensis uncharacterized protein XP_022629874.1 710805 R 1245769 CDS LALA0_S08e07756g 34687180 complement(713389..715539) Unknown 1 NW_019212886.1 similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene; uncharacterized protein 715539 34687180 LALA0_S08e07756g Lachancea lanzarotensis uncharacterized protein XP_022629875.1 713389 R 1245769 CDS LALA0_S08e07778g 34687181 complement(715780..716877) Unknown 1 NW_019212886.1 highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains; mitogen-activated serine/threonine-protein kinase KSS1 716877 34687181 LALA0_S08e07778g Lachancea lanzarotensis mitogen-activated serine/threonine-protein kinase KSS1 XP_022629876.1 715780 R 1245769 CDS LALA0_S08e07800g 34687182 717985..718851 Unknown 1 NW_019212886.1 similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C NIT3 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; uncharacterized protein 718851 34687182 LALA0_S08e07800g Lachancea lanzarotensis uncharacterized protein XP_022629877.1 717985 D 1245769 CDS LALA0_S08e07822g 34687183 complement(718991..719608) Unknown 1 NW_019212886.1 highly similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W (ohnolog of YLR350W) ORM1 Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; uncharacterized protein 719608 34687183 LALA0_S08e07822g Lachancea lanzarotensis uncharacterized protein XP_022629878.1 718991 R 1245769 CDS LALA0_S08e07844g 34687184 720720..720980 Unknown 1 NW_019212886.1 similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; long-chain fatty acid transporter ACB1 720980 34687184 LALA0_S08e07844g Lachancea lanzarotensis long-chain fatty acid transporter ACB1 XP_022629879.1 720720 D 1245769 CDS LALA0_S08e07866g 34687185 721777..724371 Unknown 1 NW_019212886.1 highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p; karyopherin beta 724371 34687185 LALA0_S08e07866g Lachancea lanzarotensis karyopherin beta XP_022629880.1 721777 D 1245769 CDS LALA0_S08e07888g 34687186 724991..725713 Unknown 1 NW_019212886.1 similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation; dolichyldiphosphatase 725713 34687186 LALA0_S08e07888g Lachancea lanzarotensis dolichyldiphosphatase XP_022629881.1 724991 D 1245769 CDS LALA0_S08e07910g 34687187 complement(725818..727515) Unknown 1 NW_019212886.1 similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene; bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase 727515 34687187 LALA0_S08e07910g Lachancea lanzarotensis bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase XP_022629882.1 725818 R 1245769 CDS LALA0_S08e07932g 34687188 complement(join(728821..729185,729583..729601)) Unknown 1 NW_019212886.1 highly similar to uniprot|P53221 Saccharomyces cerevisiae YGR034W (ohnolog of YLR344W) RPL26B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA; 60S ribosomal protein uL24 729601 34687188 LALA0_S08e07932g Lachancea lanzarotensis 60S ribosomal protein uL24 XP_022629883.1 728821 R 1245769 CDS LALA0_S08e07976g 34687190 730826..731530 Unknown 1 NW_019212886.1 similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C TIM21 Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity; uncharacterized protein 731530 34687190 LALA0_S08e07976g Lachancea lanzarotensis uncharacterized protein XP_022629884.1 730826 D 1245769 CDS LALA0_S08e07998g 34687191 complement(731756..733402) Unknown 1 NW_019212886.1 similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p; 1,3-beta-glucanosyltransferase 733402 34687191 LALA0_S08e07998g Lachancea lanzarotensis 1,3-beta-glucanosyltransferase XP_022629885.1 731756 R 1245769 CDS LALA0_S08e08020g 34687192 complement(733806..739523) Unknown 1 NW_019212886.1 highly similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W (ohnolog of YLR342W) GSC2 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p); 1,3-beta-D-glucan synthase 739523 34687192 LALA0_S08e08020g Lachancea lanzarotensis 1,3-beta-D-glucan synthase XP_022629886.1 733806 R 1245769 CDS LALA0_S08e08042g 34687193 complement(742227..743318) Unknown 1 NW_019212886.1 similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W IMO32 Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1; uncharacterized protein 743318 34687193 LALA0_S08e08042g Lachancea lanzarotensis uncharacterized protein XP_022629887.1 742227 R 1245769 CDS LALA0_S08e08064g 34687194 complement(743939..745957) Unknown 1 NW_019212886.1 similar to uniprot|C5DNK8 Lachancea thermotolerans KLTH0G17864g hypothetical protein; uncharacterized protein 745957 34687194 LALA0_S08e08064g Lachancea lanzarotensis uncharacterized protein XP_022629888.1 743939 R 1245769 CDS LALA0_S08e08086g 34687195 complement(746916..747851) Unknown 1 NW_019212886.1 highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302; 60S ribosomal protein uL10 747851 34687195 LALA0_S08e08086g Lachancea lanzarotensis 60S ribosomal protein uL10 XP_022629889.1 746916 R 1245769 CDS LALA0_S08e08108g 34687196 749397..749873 Unknown 1 NW_019212886.1 weakly similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; ribonuclease P/MRP protein subunit POP6 749873 34687196 LALA0_S08e08108g Lachancea lanzarotensis ribonuclease P/MRP protein subunit POP6 XP_022629890.1 749397 D 1245769 CDS LALA0_S08e08130g 34687197 750287..751723 Unknown 1 NW_019212886.1 similar to uniprot|C5E2R0 Lachancea thermotolerans KLTH0H06996g hypothetical protein; uncharacterized protein 751723 34687197 LALA0_S08e08130g Lachancea lanzarotensis uncharacterized protein XP_022629891.1 750287 D 1245769 CDS LALA0_S09e00100g 34687198 193..1968 Unknown 1 NW_019212887.1 similar to uniprot|Q04089 Saccharomyces cerevisiae YDR440W DOT1 Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; histone methyltransferase DOT1 1968 34687198 LALA0_S09e00100g Lachancea lanzarotensis histone methyltransferase DOT1 XP_022629892.1 193 D 1245769 CDS LALA0_S09e00122g 34687199 complement(2328..2888) Unknown 1 NW_019212887.1 highly similar to uniprot|P36973 Saccharomyces cerevisiae YDR441C (ohnolog of YML022W) APT2 Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; adenine phosphoribosyltransferase APT2 2888 34687199 LALA0_S09e00122g Lachancea lanzarotensis adenine phosphoribosyltransferase APT2 XP_022629893.1 2328 R 1245769 CDS LALA0_S09e00144g 34687200 3277..4857 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair; Smc5-Smc6 complex subunit NSE5 4857 34687200 LALA0_S09e00144g Lachancea lanzarotensis Smc5-Smc6 complex subunit NSE5 XP_022629894.1 3277 D 1245769 CDS LALA0_S09e00166g 34687201 complement(4879..8961) Unknown 1 NW_019212887.1 similar to uniprot|P38931 Saccharomyces cerevisiae YDR443C SSN2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation; uncharacterized protein 8961 34687201 LALA0_S09e00166g Lachancea lanzarotensis uncharacterized protein XP_022629895.1 4879 R 1245769 CDS LALA0_S09e00188g 34687202 9168..11054 Unknown 1 NW_019212887.1 similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W Putative protein of unknown function; uncharacterized protein 11054 34687202 LALA0_S09e00188g Lachancea lanzarotensis uncharacterized protein XP_022629896.1 9168 D 1245769 CDS LALA0_S09e00210g 34687203 complement(11196..12908) Unknown 1 NW_019212887.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; uncharacterized protein 12908 34687203 LALA0_S09e00210g Lachancea lanzarotensis uncharacterized protein XP_022629897.1 11196 R 1245769 CDS LALA0_S09e00232g 34687204 13421..14395 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure; uncharacterized protein 14395 34687204 LALA0_S09e00232g Lachancea lanzarotensis uncharacterized protein XP_022629898.1 13421 D 1245769 CDS LALA0_S09e00254g 34687205 complement(join(14661..15068,15400..15402)) Unknown 1 NW_019212887.1 highly similar to uniprot|P14127 Saccharomyces cerevisiae YDR447C (ohnolog of YML024W) RPS17B Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein; 40S ribosomal protein eS17 15402 34687205 LALA0_S09e00254g Lachancea lanzarotensis 40S ribosomal protein eS17 XP_022629899.1 14661 R 1245769 CDS LALA0_S09e00276g 34687206 16599..17900 Unknown 1 NW_019212887.1 highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes; chromatin-binding transcription regulator ADA2 17900 34687206 LALA0_S09e00276g Lachancea lanzarotensis chromatin-binding transcription regulator ADA2 XP_022629900.1 16599 D 1245769 CDS LALA0_S09e00298g 34687207 complement(17988..19346) Unknown 1 NW_019212887.1 highly similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein UTP6 19346 34687207 LALA0_S09e00298g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein UTP6 XP_022629901.1 17988 R 1245769 CDS LALA0_S09e00320g 34687208 join(19810..19845,19957..20730) Unknown 1 NW_019212887.1 similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins; mitochondrial 54S ribosomal protein uL4m 20730 34687208 LALA0_S09e00320g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL4m XP_022629902.1 19810 D 1245769 CDS LALA0_S09e00342g 34687209 join(21419..21465,21782..22175) Unknown 1 NW_019212887.1 highly similar to uniprot|P0CX55 Saccharomyces cerevisiae YDR450W (ohnolog of YML026C) RPS18A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins; 40S ribosomal protein uS13 22175 34687209 LALA0_S09e00342g Lachancea lanzarotensis 40S ribosomal protein uS13 XP_022629903.1 21419 D 1245769 CDS LALA0_S09e00364g 34687210 complement(22528..23547) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q04116 Saccharomyces cerevisiae YDR451C (ohnolog of YML027W) YHP1 One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; uncharacterized protein 23547 34687210 LALA0_S09e00364g Lachancea lanzarotensis uncharacterized protein XP_022629904.1 22528 R 1245769 CDS LALA0_S09e00386g 34687211 25038..27050 Unknown 1 NW_019212887.1 similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; endopolyphosphatase 27050 34687211 LALA0_S09e00386g Lachancea lanzarotensis endopolyphosphatase XP_022629905.1 25038 D 1245769 CDS LALA0_S09e00408g 34687212 complement(27206..27796) Unknown 1 NW_019212887.1 highly similar to uniprot|Q04120 Saccharomyces cerevisiae YDR453C (ohnolog of YML028W) TSA2 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; thioredoxin peroxidase TSA2 27796 34687212 LALA0_S09e00408g Lachancea lanzarotensis thioredoxin peroxidase TSA2 XP_022629906.1 27206 R 1245769 CDS LALA0_S09e00430g 34687213 complement(28702..31050) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p; uncharacterized protein 31050 34687213 LALA0_S09e00430g Lachancea lanzarotensis uncharacterized protein XP_022629907.1 28702 R 1245769 CDS LALA0_S09e00452g 34687214 complement(31341..31823) Unknown 1 NW_019212887.1 highly similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W AIM31 Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss; uncharacterized protein 31823 34687214 LALA0_S09e00452g Lachancea lanzarotensis uncharacterized protein XP_022629908.1 31341 R 1245769 CDS LALA0_S09e00474g 34687215 complement(32465..33022) Unknown 1 NW_019212887.1 highly similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins; guanylate kinase 33022 34687215 LALA0_S09e00474g Lachancea lanzarotensis guanylate kinase XP_022629909.1 32465 R 1245769 CDS LALA0_S09e00496g 34687216 33861..35720 Unknown 1 NW_019212887.1 highly similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; bifunctional K:H/Na:H antiporter NHX1 35720 34687216 LALA0_S09e00496g Lachancea lanzarotensis bifunctional K:H/Na:H antiporter NHX1 XP_022629910.1 33861 D 1245769 CDS LALA0_S09e00518g 34687217 complement(35812..37599) Unknown 1 NW_019212887.1 similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II; uncharacterized protein 37599 34687217 LALA0_S09e00518g Lachancea lanzarotensis uncharacterized protein XP_022629911.1 35812 R 1245769 CDS LALA0_S09e00540g 34687218 37885..39228 Unknown 1 NW_019212887.1 similar to uniprot|P06778 Saccharomyces cerevisiae YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis; recombinase RAD52 39228 34687218 LALA0_S09e00540g Lachancea lanzarotensis recombinase RAD52 XP_022629912.1 37885 D 1245769 CDS LALA0_S09e00562g 34687219 39631..49374 Unknown 1 NW_019212887.1 similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; E3 ubiquitin-protein ligase TOM1 49374 34687219 LALA0_S09e00562g Lachancea lanzarotensis E3 ubiquitin-protein ligase TOM1 XP_022629913.1 39631 D 1245769 CDS LALA0_S09e00584g 34687220 complement(49634..49876) Unknown 1 NW_019212887.1 similar to uniprot|C5DM22 Lachancea thermotolerans KLTH0G05324g hypothetical protein; uncharacterized protein 49876 34687220 LALA0_S09e00584g Lachancea lanzarotensis uncharacterized protein XP_022629914.1 49634 R 1245769 CDS LALA0_S09e00606g 34687221 complement(join(50242..50787,50884..52737)) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03281 Saccharomyces cerevisiae YDR458C (ohnolog of YML034W) HEH2 Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; uncharacterized protein 52737 34687221 LALA0_S09e00606g Lachancea lanzarotensis uncharacterized protein XP_022629915.1 50242 R 1245769 CDS LALA0_S09e00628g 34687222 54215..56506 Unknown 1 NW_019212887.1 similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools; AMP deaminase 56506 34687222 LALA0_S09e00628g Lachancea lanzarotensis AMP deaminase XP_022629916.1 54215 D 1245769 CDS LALA0_S09e00650g 34687223 complement(56585..57712) Unknown 1 NW_019212887.1 similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C PFA5 Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; palmitoyltransferase PFA5 57712 34687223 LALA0_S09e00650g Lachancea lanzarotensis palmitoyltransferase PFA5 XP_022629917.1 56585 R 1245769 CDS LALA0_S09e00672g 34687224 58006..58980 Unknown 1 NW_019212887.1 highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W TFB3 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit; TFIIH/NER complex subunit TFB3 58980 34687224 LALA0_S09e00672g Lachancea lanzarotensis TFIIH/NER complex subunit TFB3 XP_022629918.1 58006 D 1245769 CDS LALA0_S09e00694g 34687225 complement(59144..59605) Unknown 1 NW_019212887.1 similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W CGI121 Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification; uncharacterized protein 59605 34687225 LALA0_S09e00694g Lachancea lanzarotensis uncharacterized protein XP_022629919.1 59144 R 1245769 CDS LALA0_S09e00716g 34687226 59747..60832 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene; uncharacterized protein 60832 34687226 LALA0_S09e00716g Lachancea lanzarotensis uncharacterized protein XP_022629920.1 59747 D 1245769 CDS LALA0_S09e00738g 34687227 join(61146..61199,61855..62325) Unknown 1 NW_019212887.1 similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL40 62325 34687227 LALA0_S09e00738g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL40 XP_022629921.1 61146 D 1245769 CDS LALA0_S09e00760g 34687228 62699..63841 Unknown 1 NW_019212887.1 similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8 Putative nucleotide sugar transporter, has similarity to Vrg4p; uncharacterized protein 63841 34687228 LALA0_S09e00760g Lachancea lanzarotensis uncharacterized protein XP_022629922.1 62699 D 1245769 CDS LALA0_S09e00782g 34687229 64207..65817 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38704 Saccharomyces cerevisiae YHR006W (ohnolog of YDR463W) STP2 Transcriptionfactor, activated by proteolytic processing in response tosignals from the SPS sensor system for external aminoacids; activates transcription of amino acid permeasegenes; uncharacterized protein 65817 34687229 LALA0_S09e00782g Lachancea lanzarotensis uncharacterized protein XP_022629923.1 64207 D 1245769 CDS LALA0_S09e00804g 34687230 66276..71183 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3; uncharacterized protein 71183 34687230 LALA0_S09e00804g Lachancea lanzarotensis uncharacterized protein XP_022629924.1 66276 D 1245769 CDS LALA0_S09e00826g 34687231 complement(71391..73001) Unknown 1 NW_019212887.1 highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; sterol 14-demethylase 73001 34687231 LALA0_S09e00826g Lachancea lanzarotensis sterol 14-demethylase XP_022629925.1 71391 R 1245769 CDS LALA0_S09e00848g 34687232 complement(73679..74884) Unknown 1 NW_019212887.1 similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; protein-arginine N5-methyltransferase 74884 34687232 LALA0_S09e00848g Lachancea lanzarotensis protein-arginine N5-methyltransferase XP_022629926.1 73679 R 1245769 CDS LALA0_S09e00870g 34687233 complement(75113..75796) Unknown 1 NW_019212887.1 highly similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated; superoxide dismutase SOD2 75796 34687233 LALA0_S09e00870g Lachancea lanzarotensis superoxide dismutase SOD2 XP_022629927.1 75113 R 1245769 CDS LALA0_S09e00892g 34687234 77669..79504 Unknown 1 NW_019212887.1 some similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466W PKH3 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant; protein kinase PKH3 79504 34687234 LALA0_S09e00892g Lachancea lanzarotensis protein kinase PKH3 XP_022629928.1 77669 D 1245769 CDS LALA0_S09e00914g 34687235 complement(79660..81195) Unknown 1 NW_019212887.1 similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C TDA3 Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1; uncharacterized protein 81195 34687235 LALA0_S09e00914g Lachancea lanzarotensis uncharacterized protein XP_022629929.1 79660 R 1245769 CDS LALA0_S09e00936g 34687236 complement(82794..83429) Unknown 1 NW_019212887.1 similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; uncharacterized protein 83429 34687236 LALA0_S09e00936g Lachancea lanzarotensis uncharacterized protein XP_022629930.1 82794 R 1245769 CDS LALA0_S09e00958g 34687237 83579..83848 Unknown 1 NW_019212887.1 some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W SDC1 Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30; uncharacterized protein 83848 34687237 LALA0_S09e00958g Lachancea lanzarotensis uncharacterized protein XP_022629931.1 83579 D 1245769 CDS LALA0_S09e00980g 34687238 complement(84003..85445) Unknown 1 NW_019212887.1 similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1 Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion; uncharacterized protein 85445 34687238 LALA0_S09e00980g Lachancea lanzarotensis uncharacterized protein XP_022629932.1 84003 R 1245769 CDS LALA0_S09e01002g 34687239 complement(85730..86590) Unknown 1 NW_019212887.1 similar to Lachancea thermotolerans KLTH0G05874g hypothetical protein; uncharacterized protein 86590 34687239 LALA0_S09e01002g Lachancea lanzarotensis uncharacterized protein XP_022629933.1 85730 R 1245769 CDS LALA0_S09e01024g 34687240 join(87269..87299,87592..87971) Unknown 1 NW_019212887.1 highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W (ohnolog of YDR471W) RPL27A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein; 60S ribosomal protein eL27 87971 34687240 LALA0_S09e01024g Lachancea lanzarotensis 60S ribosomal protein eL27 XP_022629934.1 87269 D 1245769 CDS LALA0_S09e01046g 34687241 88235..89563 Unknown 1 NW_019212887.1 similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth; uncharacterized protein 89563 34687241 LALA0_S09e01046g Lachancea lanzarotensis uncharacterized protein XP_022629935.1 88235 D 1245769 CDS LALA0_S09e01068g 34687242 join(89800..89847,89919..90605) Unknown 1 NW_019212887.1 similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval; retromer subunit VPS29 90605 34687242 LALA0_S09e01068g Lachancea lanzarotensis retromer subunit VPS29 XP_022629936.1 89800 D 1245769 CDS LALA0_S09e01090g 34687243 complement(91274..91966) Unknown 1 NW_019212887.1 similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; peptide alpha-N-acetyltransferase complex A subunit ARD1 91966 34687243 LALA0_S09e01090g Lachancea lanzarotensis peptide alpha-N-acetyltransferase complex A subunit ARD1 XP_022629937.1 91274 R 1245769 CDS LALA0_S09e01112g 34687244 92971..93846 Unknown 1 NW_019212887.1 similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; TRAPP subunit TRS31 93846 34687244 LALA0_S09e01112g Lachancea lanzarotensis TRAPP subunit TRS31 XP_022629938.1 92971 D 1245769 CDS LALA0_S09e01134g 34687245 93914..94792 Unknown 1 NW_019212887.1 weakly similar to uniprot|P23624 Saccharomyces cerevisiae YHR014W SPO13 Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; uncharacterized protein 94792 34687245 LALA0_S09e01134g Lachancea lanzarotensis uncharacterized protein XP_022629939.1 93914 D 1245769 CDS LALA0_S09e01178g 34687247 95463..97163 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex; uncharacterized protein 97163 34687247 LALA0_S09e01178g Lachancea lanzarotensis uncharacterized protein XP_022629940.1 95463 D 1245769 CDS LALA0_S09e01200g 34687248 97334..99331 Unknown 1 NW_019212887.1 similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 99331 34687248 LALA0_S09e01200g Lachancea lanzarotensis uncharacterized protein XP_022629941.1 97334 D 1245769 CDS LALA0_S09e01222g 34687249 99469..100107 Unknown 1 NW_019212887.1 highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism; protein-arginine N-methyltransferase SFM1 100107 34687249 LALA0_S09e01222g Lachancea lanzarotensis protein-arginine N-methyltransferase SFM1 XP_022629942.1 99469 D 1245769 CDS LALA0_S09e01244g 34687250 complement(100217..100450) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q3E824 Saccharomyces cerevisiae YOR020W-A Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 100450 34687250 LALA0_S09e01244g Lachancea lanzarotensis uncharacterized protein XP_022629943.1 100217 R 1245769 CDS LALA0_S09e01266g 34687251 complement(100997..102331) Unknown 1 NW_019212887.1 similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor, component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP3 102331 34687251 LALA0_S09e01266g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP3 XP_022629944.1 100997 R 1245769 CDS LALA0_S09e01288g 34687252 complement(102768..104969) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03361 Saccharomyces cerevisiae YDR475C (ohnolog of YOR019W) JIP4 Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence; uncharacterized protein 104969 34687252 LALA0_S09e01288g Lachancea lanzarotensis uncharacterized protein XP_022629945.1 102768 R 1245769 CDS LALA0_S09e01310g 34687253 complement(join(105254..105934,106024..106101)) Unknown 1 NW_019212887.1 some similarities with uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity; uncharacterized protein 106101 34687253 LALA0_S09e01310g Lachancea lanzarotensis uncharacterized protein XP_022629946.1 105254 R 1245769 CDS LALA0_S09e01332g 34687254 complement(106497..107123) Unknown 1 NW_019212887.1 similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene; uncharacterized protein 107123 34687254 LALA0_S09e01332g Lachancea lanzarotensis uncharacterized protein XP_022629947.1 106497 R 1245769 CDS LALA0_S09e01354g 34687255 107985..109781 Unknown 1 NW_019212887.1 highly similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 109781 34687255 LALA0_S09e01354g Lachancea lanzarotensis AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 XP_022629948.1 107985 D 1245769 CDS LALA0_S09e01376g 34687256 110165..111661 Unknown 1 NW_019212887.1 similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; NAD-dependent histone deacetylase HST3 111661 34687256 LALA0_S09e01376g Lachancea lanzarotensis NAD-dependent histone deacetylase HST3 XP_022629949.1 110165 D 1245769 CDS LALA0_S09e01398g 34687257 complement(111745..113220) Unknown 1 NW_019212887.1 weakly similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p; uncharacterized protein 113220 34687257 LALA0_S09e01398g Lachancea lanzarotensis uncharacterized protein XP_022629950.1 111745 R 1245769 CDS LALA0_S09e01420g 34687258 complement(114656..115510) Unknown 1 NW_019212887.1 highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; aldo-keto reductase superfamily protein 115510 34687258 LALA0_S09e01420g Lachancea lanzarotensis aldo-keto reductase superfamily protein XP_022629951.1 114656 R 1245769 CDS LALA0_S09e01442g 34687259 complement(115930..116964) Unknown 1 NW_019212887.1 similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization; uncharacterized protein 116964 34687259 LALA0_S09e01442g Lachancea lanzarotensis uncharacterized protein XP_022629952.1 115930 R 1245769 CDS LALA0_S09e01464g 34687260 complement(join(119251..119527,119849..119850)) Unknown 1 NW_019212887.1 highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W (ohnolog of YJR094W-A) RPL43A Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype; 60S ribosomal protein eL43 119850 34687260 LALA0_S09e01464g Lachancea lanzarotensis 60S ribosomal protein eL43 XP_022629953.1 119251 R 1245769 CDS LALA0_S09e01486g 34687261 122159..122899 Unknown 1 NW_019212887.1 weakly similar to uniprot|C5DM47 Lachancea thermotolerans KLTH0G05940g hypothetical protein; uncharacterized protein 122899 34687261 LALA0_S09e01486g Lachancea lanzarotensis uncharacterized protein XP_022629954.1 122159 D 1245769 CDS LALA0_S09e01508g 34687262 123095..123832 Unknown 1 NW_019212887.1 similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; mediator complex subunit MED6 123832 34687262 LALA0_S09e01508g Lachancea lanzarotensis mediator complex subunit MED6 XP_022629955.1 123095 D 1245769 CDS LALA0_S09e01530g 34687263 124014..124634 Unknown 1 NW_019212887.1 similar to uniprot|P23285 Saccharomyces cerevisiae YHR057C (ohnolog of YDR304C) CPR2 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; uncharacterized protein 124634 34687263 LALA0_S09e01530g Lachancea lanzarotensis uncharacterized protein XP_022629956.1 124014 D 1245769 CDS LALA0_S09e01552g 34687264 124932..125738 Unknown 1 NW_019212887.1 similar to uniprot|C4Y9Y0 Clavispora lusitaniae CLUG_05201 hypothetical protein; uncharacterized protein 125738 34687264 LALA0_S09e01552g Lachancea lanzarotensis uncharacterized protein XP_022629957.1 124932 D 1245769 CDS LALA0_S09e01574g 34687265 complement(125889..126548) Unknown 1 NW_019212887.1 similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog; mannose-ethanolamine phosphotransferase GPI11 126548 34687265 LALA0_S09e01574g Lachancea lanzarotensis mannose-ethanolamine phosphotransferase GPI11 XP_022629958.1 125889 R 1245769 CDS LALA0_S09e01596g 34687266 complement(127140..131099) Unknown 1 NW_019212887.1 similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; cleavage/polyadenylation factor CFT1 131099 34687266 LALA0_S09e01596g Lachancea lanzarotensis cleavage/polyadenylation factor CFT1 XP_022629959.1 127140 R 1245769 CDS LALA0_S09e01618g 34687267 131656..132909 Unknown 1 NW_019212887.1 highly similar to uniprot|P38690 Saccharomyces cerevisiae YHR033W (ohnolog of YDR300C) Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; glutamate 5-kinase 132909 34687267 LALA0_S09e01618g Lachancea lanzarotensis glutamate 5-kinase XP_022629960.1 131656 D 1245769 CDS LALA0_S09e01640g 34687268 complement(133000..134016) Unknown 1 NW_019212887.1 similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p); uncharacterized protein 134016 34687268 LALA0_S09e01640g Lachancea lanzarotensis uncharacterized protein XP_022629961.1 133000 R 1245769 CDS LALA0_S09e01662g 34687269 135057..136670 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; uncharacterized protein 136670 34687269 LALA0_S09e01662g Lachancea lanzarotensis uncharacterized protein XP_022629962.1 135057 D 1245769 CDS LALA0_S09e01684g 34687270 complement(136731..138335) Unknown 1 NW_019212887.1 similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock; rRNA-processing protein BFR2 138335 34687270 LALA0_S09e01684g Lachancea lanzarotensis rRNA-processing protein BFR2 XP_022629963.1 136731 R 1245769 CDS LALA0_S09e01706g 34687271 139480..140103 Unknown 1 NW_019212887.1 similar to uniprot|P09457 Saccharomyces cerevisiae YDR298C ATP5 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated; F1F0 ATP synthase subunit 5 140103 34687271 LALA0_S09e01706g Lachancea lanzarotensis F1F0 ATP synthase subunit 5 XP_022629964.1 139480 D 1245769 CDS LALA0_S09e01728g 34687272 complement(140334..141335) Unknown 1 NW_019212887.1 similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis; sphingosine hydroxylase 141335 34687272 LALA0_S09e01728g Lachancea lanzarotensis sphingosine hydroxylase XP_022629965.1 140334 R 1245769 CDS LALA0_S09e01750g 34687273 complement(141995..142627) Unknown 1 NW_019212887.1 similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress; mitochondrial 54S ribosomal protein mL67 142627 34687273 LALA0_S09e01750g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL67 XP_022629966.1 141995 R 1245769 CDS LALA0_S09e01772g 34687274 144275..146278 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Putative protein of unknown function; not an essential gene; GTPase-activating protein NEL1 146278 34687274 LALA0_S09e01772g Lachancea lanzarotensis GTPase-activating protein NEL1 XP_022629967.1 144275 D 1245769 CDS LALA0_S09e01794g 34687275 147587..149425 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q06629 Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; uncharacterized protein 149425 34687275 LALA0_S09e01794g Lachancea lanzarotensis uncharacterized protein XP_022629968.1 147587 D 1245769 CDS LALA0_S09e01816g 34687276 complement(149616..150374) Unknown 1 NW_019212887.1 similar to uniprot|Q12288 Saccharomyces cerevisiae YLR126C Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; uncharacterized protein 150374 34687276 LALA0_S09e01816g Lachancea lanzarotensis uncharacterized protein XP_022629969.1 149616 R 1245769 CDS LALA0_S09e01838g 34687277 complement(151026..152261) Unknown 1 NW_019212887.1 similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W BRL1 Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export; uncharacterized protein 152261 34687277 LALA0_S09e01838g Lachancea lanzarotensis uncharacterized protein XP_022629970.1 151026 R 1245769 CDS LALA0_S09e01860g 34687278 complement(152468..154159) Unknown 1 NW_019212887.1 similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; sphinganine-1-phosphate aldolase DPL1 154159 34687278 LALA0_S09e01860g Lachancea lanzarotensis sphinganine-1-phosphate aldolase DPL1 XP_022629971.1 152468 R 1245769 CDS LALA0_S09e01882g 34687279 155492..157213 Unknown 1 NW_019212887.1 highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism; 1-pyrroline-5-carboxylate dehydrogenase 157213 34687279 LALA0_S09e01882g Lachancea lanzarotensis 1-pyrroline-5-carboxylate dehydrogenase XP_022629972.1 155492 D 1245769 CDS LALA0_S09e01904g 34687280 158062..161826 Unknown 1 NW_019212887.1 similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Translational repressor with a role in cell wall polar growth and integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control of specific mRNAs; interacts with TOR pathway components; mRNA-binding translational repressor SSD1 161826 34687280 LALA0_S09e01904g Lachancea lanzarotensis mRNA-binding translational repressor SSD1 XP_022629973.1 158062 D 1245769 CDS LALA0_S09e01926g 34687281 162103..162813 Unknown 1 NW_019212887.1 similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria; uncharacterized protein 162813 34687281 LALA0_S09e01926g Lachancea lanzarotensis uncharacterized protein XP_022629974.1 162103 D 1245769 CDS LALA0_S09e01948g 34687282 complement(162875..164812) Unknown 1 NW_019212887.1 highly similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; meiotic recombination directing protein 164812 34687282 LALA0_S09e01948g Lachancea lanzarotensis meiotic recombination directing protein XP_022629975.1 162875 R 1245769 CDS LALA0_S09e01970g 34687283 complement(join(165189..165530,165821..165823)) Unknown 1 NW_019212887.1 highly similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; H(+)-transporting V1 sector ATPase subunit G 165823 34687283 LALA0_S09e01970g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit G XP_022629976.1 165189 R 1245769 CDS LALA0_S09e01992g 34687284 166661..167932 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA; uncharacterized protein 167932 34687284 LALA0_S09e01992g Lachancea lanzarotensis uncharacterized protein XP_022629977.1 166661 D 1245769 CDS LALA0_S09e02014g 34687285 complement(168028..169611) Unknown 1 NW_019212887.1 weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Delta(9) fatty acid desaturase,required for monounsaturated fatty acid synthesis and fornormal distribution of mitochondria; uncharacterized protein 169611 34687285 LALA0_S09e02014g Lachancea lanzarotensis uncharacterized protein XP_022629978.1 168028 R 1245769 CDS LALA0_S09e02036g 34687286 170895..172655 Unknown 1 NW_019212887.1 similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p; Signal recognition particle receptor subunit alpha 172655 34687286 LALA0_S09e02036g Lachancea lanzarotensis Signal recognition particle receptor subunit alpha XP_022629979.1 170895 D 1245769 CDS LALA0_S09e02058g 34687287 complement(172733..175999) Unknown 1 NW_019212887.1 highly similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W HRQ1 Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS); ATP-dependent 3'-5' DNA helicase 175999 34687287 LALA0_S09e02058g Lachancea lanzarotensis ATP-dependent 3'-5' DNA helicase XP_022629980.1 172733 R 1245769 CDS LALA0_S09e02080g 34687288 176199..177296 Unknown 1 NW_019212887.1 similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition; uncharacterized protein 177296 34687288 LALA0_S09e02080g Lachancea lanzarotensis uncharacterized protein XP_022629981.1 176199 D 1245769 CDS LALA0_S09e02102g 34687289 complement(join(177346..177973,178053..178063)) Unknown 1 NW_019212887.1 similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance; uncharacterized protein 178063 34687289 LALA0_S09e02102g Lachancea lanzarotensis uncharacterized protein XP_022629982.1 177346 R 1245769 CDS LALA0_S09e02124g 34687290 complement(178278..183323) Unknown 1 NW_019212887.1 similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control; serine/threonine-protein kinase GCN2 183323 34687290 LALA0_S09e02124g Lachancea lanzarotensis serine/threonine-protein kinase GCN2 XP_022629983.1 178278 R 1245769 CDS LALA0_S09e02146g 34687291 complement(183601..184476) Unknown 1 NW_019212887.1 similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism; bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase 184476 34687291 LALA0_S09e02146g Lachancea lanzarotensis bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase XP_022629984.1 183601 R 1245769 CDS LALA0_S09e02168g 34687292 join(184858..185831,185911..187255) Unknown 1 NW_019212887.1 weakly similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate; uncharacterized protein 187255 34687292 LALA0_S09e02168g Lachancea lanzarotensis uncharacterized protein XP_022629985.1 184858 D 1245769 CDS LALA0_S09e02190g 34687293 complement(187271..187594) Unknown 1 NW_019212887.1 similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; uncharacterized protein 187594 34687293 LALA0_S09e02190g Lachancea lanzarotensis uncharacterized protein XP_022629986.1 187271 R 1245769 CDS LALA0_S09e02234g 34687295 188292..189182 Unknown 1 NW_019212887.1 similar to uniprot|Q05533 Saccharomyces cerevisiae YDR287W INM2 Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy; inositol monophosphate 1-phosphatase INM2 189182 34687295 LALA0_S09e02234g Lachancea lanzarotensis inositol monophosphate 1-phosphatase INM2 XP_022629987.1 188292 D 1245769 CDS LALA0_S09e02256g 34687296 189534..190388 Unknown 1 NW_019212887.1 similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth; Smc5-Smc6 complex subunit NSE3 190388 34687296 LALA0_S09e02256g Lachancea lanzarotensis Smc5-Smc6 complex subunit NSE3 XP_022629988.1 189534 D 1245769 CDS LALA0_S09e02278g 34687297 190863..192932 Unknown 1 NW_019212887.1 similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p; NADPH--hemoprotein reductase 192932 34687297 LALA0_S09e02278g Lachancea lanzarotensis NADPH--hemoprotein reductase XP_022629989.1 190863 D 1245769 CDS LALA0_S09e02300g 34687298 193101..194282 Unknown 1 NW_019212887.1 similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Putative protein of unknown function; uncharacterized protein 194282 34687298 LALA0_S09e02300g Lachancea lanzarotensis uncharacterized protein XP_022629990.1 193101 D 1245769 CDS LALA0_S09e02322g 34687299 complement(194319..195062) Unknown 1 NW_019212887.1 similar to uniprot|P38774 Saccharomyces cerevisiae YHR044C DOG1 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified; uncharacterized protein 195062 34687299 LALA0_S09e02322g Lachancea lanzarotensis uncharacterized protein XP_022629991.1 194319 R 1245769 CDS LALA0_S09e02344g 34687300 complement(195580..196497) Unknown 1 NW_019212887.1 highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); exosome non-catalytic core subunit RRP45 196497 34687300 LALA0_S09e02344g Lachancea lanzarotensis exosome non-catalytic core subunit RRP45 XP_022629992.1 195580 R 1245769 CDS LALA0_S09e02366g 34687301 complement(196721..197737) Unknown 1 NW_019212887.1 similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome; uncharacterized protein 197737 34687301 LALA0_S09e02366g Lachancea lanzarotensis uncharacterized protein XP_022629993.1 196721 R 1245769 CDS LALA0_S09e02388g 34687302 198087..199742 Unknown 1 NW_019212887.1 similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; uncharacterized protein 199742 34687302 LALA0_S09e02388g Lachancea lanzarotensis uncharacterized protein XP_022629994.1 198087 D 1245769 CDS LALA0_S09e02410g 34687303 complement(199825..200775) Unknown 1 NW_019212887.1 highly similar to uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate; inositol monophosphate 1-phosphatase INM1 200775 34687303 LALA0_S09e02410g Lachancea lanzarotensis inositol monophosphate 1-phosphatase INM1 XP_022629995.1 199825 R 1245769 CDS LALA0_S09e02432g 34687304 complement(200961..203549) Unknown 1 NW_019212887.1 similar to uniprot|P37898 Saccharomyces cerevisiae YHR047C (ohnolog of YKL157W) AAP1 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation; arginine/alanine aminopeptidase 203549 34687304 LALA0_S09e02432g Lachancea lanzarotensis arginine/alanine aminopeptidase XP_022629996.1 200961 R 1245769 CDS LALA0_S09e02454g 34687305 206326..207807 Unknown 1 NW_019212887.1 similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W YHK8 Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles; uncharacterized protein 207807 34687305 LALA0_S09e02454g Lachancea lanzarotensis uncharacterized protein XP_022629997.1 206326 D 1245769 CDS LALA0_S09e02476g 34687306 208352..209068 Unknown 1 NW_019212887.1 highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W FSH1 Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2; uncharacterized protein 209068 34687306 LALA0_S09e02476g Lachancea lanzarotensis uncharacterized protein XP_022629998.1 208352 D 1245769 CDS LALA0_S09e02498g 34687307 210110..211126 Unknown 1 NW_019212887.1 similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C CWC2 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2; uncharacterized protein 211126 34687307 LALA0_S09e02498g Lachancea lanzarotensis uncharacterized protein XP_022629999.1 210110 D 1245769 CDS LALA0_S09e02520g 34687308 complement(211171..212895) Unknown 1 NW_019212887.1 similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site; mRNA splicing protein PRP28 212895 34687308 LALA0_S09e02520g Lachancea lanzarotensis mRNA splicing protein PRP28 XP_022630000.1 211171 R 1245769 CDS LALA0_S09e02542g 34687309 213873..215279 Unknown 1 NW_019212887.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; uncharacterized protein 215279 34687309 LALA0_S09e02542g Lachancea lanzarotensis uncharacterized protein XP_022630001.1 213873 D 1245769 CDS LALA0_S09e02564g 34687310 215484..216119 Unknown 1 NW_019212887.1 weakly similar to uniprot|C5DIN5 Lachancea thermotolerans KLTH0E13904g hypothetical protein; uncharacterized protein 216119 34687310 LALA0_S09e02564g Lachancea lanzarotensis uncharacterized protein XP_022630002.1 215484 D 1245769 CDS LALA0_S09e02586g 34687311 216628..218349 Unknown 1 NW_019212887.1 similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions; uncharacterized protein 218349 34687311 LALA0_S09e02586g Lachancea lanzarotensis uncharacterized protein XP_022630003.1 216628 D 1245769 CDS LALA0_S09e02608g 34687312 218676..219689 Unknown 1 NW_019212887.1 similar to uniprot|P50108 Saccharomyces cerevisiae YDR245W MNN10 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; alpha-1,6-mannosyltransferase 219689 34687312 LALA0_S09e02608g Lachancea lanzarotensis alpha-1,6-mannosyltransferase XP_022630004.1 218676 D 1245769 CDS LALA0_S09e02630g 34687313 220362..223673 Unknown 1 NW_019212887.1 weakly similar to uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; uncharacterized protein 223673 34687313 LALA0_S09e02630g Lachancea lanzarotensis uncharacterized protein XP_022630005.1 220362 D 1245769 CDS LALA0_S09e02652g 34687314 complement(223769..226900) Unknown 1 NW_019212887.1 similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein; ssDNA endodeoxyribonuclease RAD1 226900 34687314 LALA0_S09e02652g Lachancea lanzarotensis ssDNA endodeoxyribonuclease RAD1 XP_022630006.1 223769 R 1245769 CDS LALA0_S09e02674g 34687315 228131..228682 Unknown 1 NW_019212887.1 highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; Arf family GTPase ARL1 228682 34687315 LALA0_S09e02674g Lachancea lanzarotensis Arf family GTPase ARL1 XP_022630007.1 228131 D 1245769 CDS LALA0_S09e02696g 34687316 join(228960..230698,230782..230917,230990..231034) Unknown 1 NW_019212887.1 similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 231034 34687316 LALA0_S09e02696g Lachancea lanzarotensis uncharacterized protein XP_022630008.1 228960 D 1245769 CDS LALA0_S09e02718g 34687317 231227..235009 Unknown 1 NW_019212887.1 similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C GDE1 Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes; glycerophosphocholine phosphodiesterase 235009 34687317 LALA0_S09e02718g Lachancea lanzarotensis glycerophosphocholine phosphodiesterase XP_022630009.1 231227 D 1245769 CDS LALA0_S09e02740g 34687318 complement(235119..235508) Unknown 1 NW_019212887.1 similar to uniprot|C5DIN8 Lachancea thermotolerans KLTH0E13970g hypothetical protein; uncharacterized protein 235508 34687318 LALA0_S09e02740g Lachancea lanzarotensis uncharacterized protein XP_022630010.1 235119 R 1245769 CDS LALA0_S09e02762g 34687319 238248..240335 Unknown 1 NW_019212887.1 similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W (ohnolog of YMR246W) FAA1 Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; uncharacterized protein 240335 34687319 LALA0_S09e02762g Lachancea lanzarotensis uncharacterized protein XP_022630011.1 238248 D 1245769 CDS LALA0_S09e02784g 34687320 241030..241914 Unknown 1 NW_019212887.1 similar to uniprot|C5DIN8 Lachancea thermotolerans KLTH0E13970g hypothetical protein; uncharacterized protein 241914 34687320 LALA0_S09e02784g Lachancea lanzarotensis uncharacterized protein XP_022630012.1 241030 D 1245769 CDS LALA0_S09e02806g 34687321 242282..246928 Unknown 1 NW_019212887.1 similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C RKR1 RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice; ubiquitin-protein ligase RKR1 246928 34687321 LALA0_S09e02806g Lachancea lanzarotensis ubiquitin-protein ligase RKR1 XP_022630013.1 242282 D 1245769 CDS LALA0_S09e02828g 34687322 247320..248774 Unknown 1 NW_019212887.1 similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus; glucose N-acetyltransferase 248774 34687322 LALA0_S09e02828g Lachancea lanzarotensis glucose N-acetyltransferase XP_022630014.1 247320 D 1245769 CDS LALA0_S09e02850g 34687323 complement(248804..249454) Unknown 1 NW_019212887.1 similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W HSH49 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); U2 snRNP complex subunit HSH49 249454 34687323 LALA0_S09e02850g Lachancea lanzarotensis U2 snRNP complex subunit HSH49 XP_022630015.1 248804 R 1245769 CDS LALA0_S09e02872g 34687324 251410..252591 Unknown 1 NW_019212887.1 similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically; adenosylmethionine decarboxylase SPE2 252591 34687324 LALA0_S09e02872g Lachancea lanzarotensis adenosylmethionine decarboxylase SPE2 XP_022630016.1 251410 D 1245769 CDS LALA0_S09e02894g 34687325 252958..254676 Unknown 1 NW_019212887.1 similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress; glutamate decarboxylase GAD1 254676 34687325 LALA0_S09e02894g Lachancea lanzarotensis glutamate decarboxylase GAD1 XP_022630017.1 252958 D 1245769 CDS LALA0_S09e02916g 34687326 256720..256887 Unknown 1 NW_019212887.1 hypothetical protein; uncharacterized protein 256887 34687326 LALA0_S09e02916g Lachancea lanzarotensis uncharacterized protein XP_022630018.1 256720 D 1245769 CDS LALA0_S09e02938g 34687327 join(260140..260200,260302..261518) Unknown 1 NW_019212887.1 similar to uniprot|Q12355 Saccharomyces cerevisiae YDR055W (ohnolog of YBR078W) PST1 Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; uncharacterized protein 261518 34687327 LALA0_S09e02938g Lachancea lanzarotensis uncharacterized protein XP_022630019.1 260140 D 1245769 CDS LALA0_S09e02960g 34687328 complement(262226..262819) Unknown 1 NW_019212887.1 highly similar to uniprot|C5DH44 Lachancea thermotolerans KLTH0E01232g hypothetical protein; uncharacterized protein 262819 34687328 LALA0_S09e02960g Lachancea lanzarotensis uncharacterized protein XP_022630020.1 262226 R 1245769 CDS LALA0_S09e02982g 34687329 complement(263338..266259) Unknown 1 NW_019212887.1 similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation; translation initiation factor eIF3 core subunit a 266259 34687329 LALA0_S09e02982g Lachancea lanzarotensis translation initiation factor eIF3 core subunit a XP_022630021.1 263338 R 1245769 CDS LALA0_S09e03004g 34687330 complement(266492..268783) Unknown 1 NW_019212887.1 highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF; AAA family ATPase SEC18 268783 34687330 LALA0_S09e03004g Lachancea lanzarotensis AAA family ATPase SEC18 XP_022630022.1 266492 R 1245769 CDS LALA0_S09e03026g 34687331 complement(join(269110..269448,269520..269759)) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q12025 Saccharomyces cerevisiae YDR056C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein; uncharacterized protein 269759 34687331 LALA0_S09e03026g Lachancea lanzarotensis uncharacterized protein XP_022630023.1 269110 R 1245769 CDS LALA0_S09e03048g 34687332 270000..271547 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family; uncharacterized protein 271547 34687332 LALA0_S09e03048g Lachancea lanzarotensis uncharacterized protein XP_022630024.1 270000 D 1245769 CDS LALA0_S09e03070g 34687333 complement(271633..275535) Unknown 1 NW_019212887.1 similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; SAGA histone acetyltransferase complex subunit SPT7 275535 34687333 LALA0_S09e03070g Lachancea lanzarotensis SAGA histone acetyltransferase complex subunit SPT7 XP_022630025.1 271633 R 1245769 CDS LALA0_S09e03114g 34687335 complement(join(276713..277112,277470..277513)) Unknown 1 NW_019212887.1 highly similar to uniprot|P15732 Saccharomyces cerevisiae YDR059C (ohnolog of YBR082C) UBC5 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; uncharacterized protein 277513 34687335 LALA0_S09e03114g Lachancea lanzarotensis uncharacterized protein XP_022630026.1 276713 R 1245769 CDS LALA0_S09e03136g 34687336 279246..282356 Unknown 1 NW_019212887.1 similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein; RNA-binding ribosome biosynthesis protein MAK21 282356 34687336 LALA0_S09e03136g Lachancea lanzarotensis RNA-binding ribosome biosynthesis protein MAK21 XP_022630027.1 279246 D 1245769 CDS LALA0_S09e03158g 34687337 283242..284669 Unknown 1 NW_019212887.1 weakly similar to uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member; uncharacterized protein 284669 34687337 LALA0_S09e03158g Lachancea lanzarotensis uncharacterized protein XP_022630028.1 283242 D 1245769 CDS LALA0_S09e03180g 34687338 285951..288878 Unknown 1 NW_019212887.1 highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 288878 34687338 LALA0_S09e03180g Lachancea lanzarotensis trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 XP_022630029.1 285951 D 1245769 CDS LALA0_S09e03202g 34687339 complement(join(289179..289746,290073..290074)) Unknown 1 NW_019212887.1 highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A (ohnolog of YBL027W) RPL19A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; 60S ribosomal protein eL19 290074 34687339 LALA0_S09e03202g Lachancea lanzarotensis 60S ribosomal protein eL19 XP_022630030.1 289179 R 1245769 CDS LALA0_S09e03224g 34687340 290591..290929 Unknown 1 NW_019212887.1 similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis; uncharacterized protein 290929 34687340 LALA0_S09e03224g Lachancea lanzarotensis uncharacterized protein XP_022630031.1 290591 D 1245769 CDS LALA0_S09e03246g 34687341 complement(291368..292675) Unknown 1 NW_019212887.1 weakly similar to uniprot|P38201 Saccharomyces cerevisiae YBL029W Non-essential protein of unknown function; uncharacterized protein 292675 34687341 LALA0_S09e03246g Lachancea lanzarotensis uncharacterized protein XP_022630032.1 291368 R 1245769 CDS LALA0_S09e03268g 34687342 294478..294765 Unknown 1 NW_019212887.1 similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica; uncharacterized protein 294765 34687342 LALA0_S09e03268g Lachancea lanzarotensis uncharacterized protein XP_022630033.1 294478 D 1245769 CDS LALA0_S09e03290g 34687343 complement(294835..297489) Unknown 1 NW_019212887.1 weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 297489 34687343 LALA0_S09e03290g Lachancea lanzarotensis uncharacterized protein XP_022630034.1 294835 R 1245769 CDS LALA0_S09e03312g 34687344 299062..299976 Unknown 1 NW_019212887.1 highly similar to uniprot|P18238 Saccharomyces cerevisiae YBR085W (ohnolog of YBL030C) AAC3 Mitochondrialinner membrane ADP/ATP translocator, exchanges cytosolicADP for mitochondrially synthesized ATP; expressed underanaerobic conditions; similar to Pet9p and Aac1p; hasroles in maintenance of viability and in respiration; ADP/ATP carrier protein PET9 299976 34687344 LALA0_S09e03312g Lachancea lanzarotensis ADP/ATP carrier protein PET9 XP_022630035.1 299062 D 1245769 CDS LALA0_S09e03334g 34687345 complement(300302..301339) Unknown 1 NW_019212887.1 weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; uncharacterized protein 301339 34687345 LALA0_S09e03334g Lachancea lanzarotensis uncharacterized protein XP_022630036.1 300302 R 1245769 CDS LALA0_S09e03356g 34687346 complement(301698..302555) Unknown 1 NW_019212887.1 similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W HEK2 RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K; uncharacterized protein 302555 34687346 LALA0_S09e03356g Lachancea lanzarotensis uncharacterized protein XP_022630037.1 301698 R 1245769 CDS LALA0_S09e03378g 34687347 304084..305019 Unknown 1 NW_019212887.1 similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway; GTP cyclohydrolase II 305019 34687347 LALA0_S09e03378g Lachancea lanzarotensis GTP cyclohydrolase II XP_022630038.1 304084 D 1245769 CDS LALA0_S09e03400g 34687348 complement(305347..305598) Unknown 1 NW_019212887.1 similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; uncharacterized protein 305598 34687348 LALA0_S09e03400g Lachancea lanzarotensis uncharacterized protein XP_022630039.1 305347 R 1245769 CDS LALA0_S09e03422g 34687349 306212..310333 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles; uncharacterized protein 310333 34687349 LALA0_S09e03422g Lachancea lanzarotensis uncharacterized protein XP_022630040.1 306212 D 1245769 CDS LALA0_S09e03444g 34687350 310456..312426 Unknown 1 NW_019212887.1 similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation; DNA-directed DNA polymerase alpha subunit POL12 312426 34687350 LALA0_S09e03444g Lachancea lanzarotensis DNA-directed DNA polymerase alpha subunit POL12 XP_022630041.1 310456 D 1245769 CDS LALA0_S09e03466g 34687351 complement(312551..315169) Unknown 1 NW_019212887.1 weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2 Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process; uncharacterized protein 315169 34687351 LALA0_S09e03466g Lachancea lanzarotensis uncharacterized protein XP_022630042.1 312551 R 1245769 CDS LALA0_S09e03488g 34687352 316457..317212 Unknown 1 NW_019212887.1 similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS; uncharacterized protein 317212 34687352 LALA0_S09e03488g Lachancea lanzarotensis uncharacterized protein XP_022630043.1 316457 D 1245769 CDS LALA0_S09e03510g 34687353 complement(317361..320279) Unknown 1 NW_019212887.1 similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; uncharacterized protein 320279 34687353 LALA0_S09e03510g Lachancea lanzarotensis uncharacterized protein XP_022630044.1 317361 R 1245769 CDS LALA0_S09e03532g 34687354 320598..321674 Unknown 1 NW_019212887.1 highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 5 321674 34687354 LALA0_S09e03532g Lachancea lanzarotensis replication factor C subunit 5 XP_022630045.1 320598 D 1245769 CDS LALA0_S09e03554g 34687355 complement(321875..322528) Unknown 1 NW_019212887.1 similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL16m 322528 34687355 LALA0_S09e03554g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL16m XP_022630046.1 321875 R 1245769 CDS LALA0_S09e03576g 34687356 323253..324668 Unknown 1 NW_019212887.1 similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W MSF1 Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase; phenylalanine--tRNA ligase 324668 34687356 LALA0_S09e03576g Lachancea lanzarotensis phenylalanine--tRNA ligase XP_022630047.1 323253 D 1245769 CDS LALA0_S09e03598g 34687357 324873..326714 Unknown 1 NW_019212887.1 similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; NAPDH-dependent diflavin reductase 326714 34687357 LALA0_S09e03598g Lachancea lanzarotensis NAPDH-dependent diflavin reductase XP_022630048.1 324873 D 1245769 CDS LALA0_S09e03620g 34687358 complement(326946..330242) Unknown 1 NW_019212887.1 similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS); autophagy protein ATG11 330242 34687358 LALA0_S09e03620g Lachancea lanzarotensis autophagy protein ATG11 XP_022630049.1 326946 R 1245769 CDS LALA0_S09e03642g 34687359 330805..331332 Unknown 1 NW_019212887.1 similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; peptide alpha-N-acetyltransferase MAK3 331332 34687359 LALA0_S09e03642g Lachancea lanzarotensis peptide alpha-N-acetyltransferase MAK3 XP_022630050.1 330805 D 1245769 CDS LALA0_S09e03664g 34687360 complement(331494..332270) Unknown 1 NW_019212887.1 highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; proliferating cell nuclear antigen 332270 34687360 LALA0_S09e03664g Lachancea lanzarotensis proliferating cell nuclear antigen XP_022630051.1 331494 R 1245769 CDS LALA0_S09e03686g 34687361 complement(333001..333282) Unknown 1 NW_019212887.1 highly similar to uniprot|P11633 Saccharomyces cerevisiae YBR089C-A (ohnolog of YPR052C) NHP6B High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; high-mobility group nucleosome-binding protein 333282 34687361 LALA0_S09e03686g Lachancea lanzarotensis high-mobility group nucleosome-binding protein XP_022630052.1 333001 R 1245769 CDS LALA0_S09e03708g 34687362 complement(335309..335605) Unknown 1 NW_019212887.1 similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C TIM12 Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins; uncharacterized protein 335605 34687362 LALA0_S09e03708g Lachancea lanzarotensis uncharacterized protein XP_022630053.1 335309 R 1245769 CDS LALA0_S09e03730g 34687363 join(336245..336256,336482..338674) Unknown 1 NW_019212887.1 similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W PBY1 Putative tubulin tyrosine ligase associated with P-bodies; uncharacterized protein 338674 34687363 LALA0_S09e03730g Lachancea lanzarotensis uncharacterized protein XP_022630054.1 336245 D 1245769 CDS LALA0_S09e03752g 34687364 complement(338739..339776) Unknown 1 NW_019212887.1 similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; uncharacterized protein 339776 34687364 LALA0_S09e03752g Lachancea lanzarotensis uncharacterized protein XP_022630055.1 338739 R 1245769 CDS LALA0_S09e03774g 34687365 340519..341211 Unknown 1 NW_019212887.1 similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; uncharacterized protein 341211 34687365 LALA0_S09e03774g Lachancea lanzarotensis uncharacterized protein XP_022630056.1 340519 D 1245769 CDS LALA0_S09e03796g 34687366 341674..342930 Unknown 1 NW_019212887.1 similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p; mitogen-activated protein kinase SMK1 342930 34687366 LALA0_S09e03796g Lachancea lanzarotensis mitogen-activated protein kinase SMK1 XP_022630057.1 341674 D 1245769 CDS LALA0_S09e03818g 34687367 343297..347568 Unknown 1 NW_019212887.1 similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; ubiquitin-binding serine/threonine protein kinase VPS15 347568 34687367 LALA0_S09e03818g Lachancea lanzarotensis ubiquitin-binding serine/threonine protein kinase VPS15 XP_022630058.1 343297 D 1245769 CDS LALA0_S09e03840g 34687368 348112..351165 Unknown 1 NW_019212887.1 similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC8 351165 34687368 LALA0_S09e03840g Lachancea lanzarotensis exocyst subunit SEC8 XP_022630059.1 348112 D 1245769 CDS LALA0_S09e03862g 34687369 351376..353304 Unknown 1 NW_019212887.1 weakly similar to uniprot|P38257 Saccharomyces cerevisiae YBR098W MMS4 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; uncharacterized protein 353304 34687369 LALA0_S09e03862g Lachancea lanzarotensis uncharacterized protein XP_022630060.1 351376 D 1245769 CDS LALA0_S09e03884g 34687370 complement(353378..354253) Unknown 1 NW_019212887.1 similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; Hsp70 nucleotide exchange factor FES1 354253 34687370 LALA0_S09e03884g Lachancea lanzarotensis Hsp70 nucleotide exchange factor FES1 XP_022630061.1 353378 R 1245769 CDS LALA0_S09e03906g 34687371 complement(354856..356997) Unknown 1 NW_019212887.1 similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit EXO84 356997 34687371 LALA0_S09e03906g Lachancea lanzarotensis exocyst subunit EXO84 XP_022630062.1 354856 R 1245769 CDS LALA0_S09e03928g 34687372 357282..358832 Unknown 1 NW_019212887.1 similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus; uncharacterized protein 358832 34687372 LALA0_S09e03928g Lachancea lanzarotensis uncharacterized protein XP_022630063.1 357282 D 1245769 CDS LALA0_S09e03950g 34687373 359159..360178 Unknown 1 NW_019212887.1 highly similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W TFB4 Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p; TFIIH/NER complex subunit TFB4 360178 34687373 LALA0_S09e03950g Lachancea lanzarotensis TFIIH/NER complex subunit TFB4 XP_022630064.1 359159 D 1245769 CDS LALA0_S09e03972g 34687374 360624..361694 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; uncharacterized protein 361694 34687374 LALA0_S09e03972g Lachancea lanzarotensis uncharacterized protein XP_022630065.1 360624 D 1245769 CDS LALA0_S09e03994g 34687375 362110..362931 Unknown 1 NW_019212887.1 similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; uncharacterized protein 362931 34687375 LALA0_S09e03994g Lachancea lanzarotensis uncharacterized protein XP_022630066.1 362110 D 1245769 CDS LALA0_S09e04016g 34687376 complement(join(363226..365166,365249..365272)) Unknown 1 NW_019212887.1 similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family; phosphatidylinositol-3-phosphatase YMR1 365272 34687376 LALA0_S09e04016g Lachancea lanzarotensis phosphatidylinositol-3-phosphatase YMR1 XP_022630067.1 363226 R 1245769 CDS LALA0_S09e04038g 34687377 complement(365932..366285) Unknown 1 NW_019212887.1 similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase; uncharacterized protein 366285 34687377 LALA0_S09e04038g Lachancea lanzarotensis uncharacterized protein XP_022630068.1 365932 R 1245769 CDS LALA0_S09e04060g 34687378 complement(366969..369116) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; uncharacterized protein 369116 34687378 LALA0_S09e04060g Lachancea lanzarotensis uncharacterized protein XP_022630069.1 366969 R 1245769 CDS LALA0_S09e04082g 34687379 complement(join(370837..371685,371760..371789)) Unknown 1 NW_019212887.1 similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17 Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP; uncharacterized protein 371789 34687379 LALA0_S09e04082g Lachancea lanzarotensis uncharacterized protein XP_022630070.1 370837 R 1245769 CDS LALA0_S09e04104g 34687380 complement(372213..374351) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; uncharacterized protein 374351 34687380 LALA0_S09e04104g Lachancea lanzarotensis uncharacterized protein XP_022630071.1 372213 R 1245769 CDS LALA0_S09e04126g 34687381 379275..381737 Unknown 1 NW_019212887.1 similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; uncharacterized protein 381737 34687381 LALA0_S09e04126g Lachancea lanzarotensis uncharacterized protein XP_022630072.1 379275 D 1245769 CDS LALA0_S09e04148g 34687382 382860..386216 Unknown 1 NW_019212887.1 highly similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 386216 34687382 LALA0_S09e04148g Lachancea lanzarotensis carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 XP_022630073.1 382860 D 1245769 CDS LALA0_S09e04170g 34687383 387386..388930 Unknown 1 NW_019212887.1 some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p; uncharacterized protein 388930 34687383 LALA0_S09e04170g Lachancea lanzarotensis uncharacterized protein XP_022630074.1 387386 D 1245769 CDS LALA0_S09e04192g 34687384 391450..392778 Unknown 1 NW_019212887.1 similar to uniprot|P10823 Saccharomyces cerevisiae YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; guanine nucleotide-binding protein subunit alpha 392778 34687384 LALA0_S09e04192g Lachancea lanzarotensis guanine nucleotide-binding protein subunit alpha XP_022630075.1 391450 D 1245769 CDS LALA0_S09e04214g 34687385 complement(393086..394282) Unknown 1 NW_019212887.1 similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Putative protein of unknown function; has sequence or structural similarity to lipases; uncharacterized protein 394282 34687385 LALA0_S09e04214g Lachancea lanzarotensis uncharacterized protein XP_022630076.1 393086 R 1245769 CDS LALA0_S09e04236g 34687386 complement(394527..396566) Unknown 1 NW_019212887.1 similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p; uncharacterized protein 396566 34687386 LALA0_S09e04236g Lachancea lanzarotensis uncharacterized protein XP_022630077.1 394527 R 1245769 CDS LALA0_S09e04258g 34687387 complement(396769..397800) Unknown 1 NW_019212887.1 highly similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle; adenosine kinase 397800 34687387 LALA0_S09e04258g Lachancea lanzarotensis adenosine kinase XP_022630078.1 396769 R 1245769 CDS LALA0_S09e04280g 34687388 401236..402048 Unknown 1 NW_019212887.1 similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W TDA4 Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; uncharacterized protein 402048 34687388 LALA0_S09e04280g Lachancea lanzarotensis uncharacterized protein XP_022630079.1 401236 D 1245769 CDS LALA0_S09e04302g 34687389 402552..403919 Unknown 1 NW_019212887.1 similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans; zinc metalloprotease 403919 34687389 LALA0_S09e04302g Lachancea lanzarotensis zinc metalloprotease XP_022630080.1 402552 D 1245769 CDS LALA0_S09e04324g 34687390 404282..406594 Unknown 1 NW_019212887.1 weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin; uncharacterized protein 406594 34687390 LALA0_S09e04324g Lachancea lanzarotensis uncharacterized protein XP_022630081.1 404282 D 1245769 CDS LALA0_S09e04346g 34687391 407383..408432 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q12416 Saccharomyces cerevisiae YOR083W (ohnolog of YKR091W) WHI5 Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1; uncharacterized protein 408432 34687391 LALA0_S09e04346g Lachancea lanzarotensis uncharacterized protein XP_022630082.1 407383 D 1245769 CDS LALA0_S09e04368g 34687392 408736..409857 Unknown 1 NW_019212887.1 similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W LPX1 Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction; triglyceride lipase 409857 34687392 LALA0_S09e04368g Lachancea lanzarotensis triglyceride lipase XP_022630083.1 408736 D 1245769 CDS LALA0_S09e04390g 34687393 complement(410013..411161) Unknown 1 NW_019212887.1 similar to uniprot|C5DH34 Lachancea thermotolerans KLTH0E01012g hypothetical protein; uncharacterized protein 411161 34687393 LALA0_S09e04390g Lachancea lanzarotensis uncharacterized protein XP_022630084.1 410013 R 1245769 CDS LALA0_S09e04412g 34687394 411549..414101 Unknown 1 NW_019212887.1 highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2 Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3; TFIIH/NER complex ATPase/helicase subunit SSL2 414101 34687394 LALA0_S09e04412g Lachancea lanzarotensis TFIIH/NER complex ATPase/helicase subunit SSL2 XP_022630085.1 411549 D 1245769 CDS LALA0_S09e04434g 34687395 complement(414198..416231) Unknown 1 NW_019212887.1 similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering; kinetochore-associated Ndc80 complex subunit NDC80 416231 34687395 LALA0_S09e04434g Lachancea lanzarotensis kinetochore-associated Ndc80 complex subunit NDC80 XP_022630086.1 414198 R 1245769 CDS LALA0_S09e04456g 34687396 417084..418001 Unknown 1 NW_019212887.1 similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; pantoate--beta-alanine ligase PAN6 418001 34687396 LALA0_S09e04456g Lachancea lanzarotensis pantoate--beta-alanine ligase PAN6 XP_022630087.1 417084 D 1245769 CDS LALA0_S09e04478g 34687397 418580..420301 Unknown 1 NW_019212887.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; uncharacterized protein 420301 34687397 LALA0_S09e04478g Lachancea lanzarotensis uncharacterized protein XP_022630088.1 418580 D 1245769 CDS LALA0_S09e04500g 34687398 421515..423050 Unknown 1 NW_019212887.1 weakly similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ATG32 Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; mitophagy protein ATG32 423050 34687398 LALA0_S09e04500g Lachancea lanzarotensis mitophagy protein ATG32 XP_022630089.1 421515 D 1245769 CDS LALA0_S09e04522g 34687399 423464..426862 Unknown 1 NW_019212887.1 similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; histidine kinase 426862 34687399 LALA0_S09e04522g Lachancea lanzarotensis histidine kinase XP_022630090.1 423464 D 1245769 CDS LALA0_S09e04544g 34687400 complement(join(427103..427481,427836..427843)) Unknown 1 NW_019212887.1 some similarities with uniprot|P0CH08 Saccharomyces cerevisiae YIL148W (ohnolog of YKR094C) RPL40A Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; uncharacterized protein 427843 34687400 LALA0_S09e04544g Lachancea lanzarotensis uncharacterized protein XP_022630091.1 427103 R 1245769 CDS LALA0_S09e04566g 34687401 428609..433990 Unknown 1 NW_019212887.1 similar to uniprot|P40457 Saccharomyces cerevisiae YIL149C (ohnolog of YKR095W) MLP2 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; uncharacterized protein 433990 34687401 LALA0_S09e04566g Lachancea lanzarotensis uncharacterized protein XP_022630092.1 428609 D 1245769 CDS LALA0_S09e04588g 34687402 join(435332..435419,435503..437175) Unknown 1 NW_019212887.1 similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins; uncharacterized protein 437175 34687402 LALA0_S09e04588g Lachancea lanzarotensis uncharacterized protein XP_022630093.1 435332 D 1245769 CDS LALA0_S09e04610g 34687403 complement(437181..438359) Unknown 1 NW_019212887.1 similar to uniprot|C5DH31 Lachancea thermotolerans KLTH0E00946g hypothetical protein; uncharacterized protein 438359 34687403 LALA0_S09e04610g Lachancea lanzarotensis uncharacterized protein XP_022630094.1 437181 R 1245769 CDS LALA0_S09e04632g 34687404 join(438970..439007,439079..439307) Unknown 1 NW_019212887.1 similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; chromatin DNA-binding EKC/KEOPS complex subunit PCC1 439307 34687404 LALA0_S09e04632g Lachancea lanzarotensis chromatin DNA-binding EKC/KEOPS complex subunit PCC1 XP_022630095.1 438970 D 1245769 CDS LALA0_S09e04654g 34687405 440014..443559 Unknown 1 NW_019212887.1 similar to uniprot|P40456 Saccharomyces cerevisiae YIL151C (ohnolog of YKR096W) Putative protein of unknown function, predicted to contain a PINc domain; uncharacterized protein 443559 34687405 LALA0_S09e04654g Lachancea lanzarotensis uncharacterized protein XP_022630096.1 440014 D 1245769 CDS LALA0_S09e04676g 34687406 complement(443765..444415) Unknown 1 NW_019212887.1 similar to uniprot|G8BPP0 Tetrapisispora phaffii TPHA0B02990 hypothetical protein; uncharacterized protein 444415 34687406 LALA0_S09e04676g Lachancea lanzarotensis uncharacterized protein XP_022630097.1 443765 R 1245769 CDS LALA0_S09e04698g 34687407 complement(446030..447358) Unknown 1 NW_019212887.1 similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA; uncharacterized protein 447358 34687407 LALA0_S09e04698g Lachancea lanzarotensis uncharacterized protein XP_022630098.1 446030 R 1245769 CDS LALA0_S09e04720g 34687408 449549..457744 Unknown 1 NW_019212887.1 similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 457744 34687408 LALA0_S09e04720g Lachancea lanzarotensis uncharacterized protein XP_022630099.1 449549 D 1245769 CDS LALA0_S09e04742g 34687409 join(458226..459507,460260..460648) Unknown 1 NW_019212887.1 highly similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing; DEAD-box ATP-dependent RNA helicase DBP2 460648 34687409 LALA0_S09e04742g Lachancea lanzarotensis DEAD-box ATP-dependent RNA helicase DBP2 XP_022630100.1 458226 D 1245769 CDS LALA0_S09e04764g 34687410 complement(460797..462929) Unknown 1 NW_019212887.1 similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W CEX1 Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p; uncharacterized protein 462929 34687410 LALA0_S09e04764g Lachancea lanzarotensis uncharacterized protein XP_022630101.1 460797 R 1245769 CDS LALA0_S09e04786g 34687411 complement(463210..463581) Unknown 1 NW_019212887.1 similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation; uncharacterized protein 463581 34687411 LALA0_S09e04786g Lachancea lanzarotensis uncharacterized protein XP_022630102.1 463210 R 1245769 CDS LALA0_S09e04808g 34687412 complement(465047..465712) Unknown 1 NW_019212887.1 similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; rRNA-binding ribosome biosynthesis protein NOP15 465712 34687412 LALA0_S09e04808g Lachancea lanzarotensis rRNA-binding ribosome biosynthesis protein NOP15 XP_022630103.1 465047 R 1245769 CDS LALA0_S09e04830g 34687413 complement(466309..466989) Unknown 1 NW_019212887.1 similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Putative protein of unknown function; nucleotide diphosphatase 466989 34687413 LALA0_S09e04830g Lachancea lanzarotensis nucleotide diphosphatase XP_022630104.1 466309 R 1245769 CDS LALA0_S09e04852g 34687414 complement(join(467256..468488,468587..468616)) Unknown 1 NW_019212887.1 similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W (ohnolog of YNL108C) TFC7 One of six subunits ofthe RNA polymerase III transcription initiation factorcomplex (TFIIIC); part of the TauA globular domain ofTFIIIC that binds DNA at the BoxA promoter sites of tRNAand similar genes; uncharacterized protein 468616 34687414 LALA0_S09e04852g Lachancea lanzarotensis uncharacterized protein XP_022630105.1 467256 R 1245769 CDS LALA0_S09e04874g 34687415 468805..469458 Unknown 1 NW_019212887.1 similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain; YEATS domain-containing protein YAF9 469458 34687415 LALA0_S09e04874g Lachancea lanzarotensis YEATS domain-containing protein YAF9 XP_022630106.1 468805 D 1245769 CDS LALA0_S09e04896g 34687416 complement(469598..473011) Unknown 1 NW_019212887.1 similar to uniprot|Q12271 Saccharomyces cerevisiae YOR109W (ohnolog of YNL106C) INP53 Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 473011 34687416 LALA0_S09e04896g Lachancea lanzarotensis phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 XP_022630107.1 469598 R 1245769 CDS LALA0_S09e04918g 34687417 complement(473718..475547) Unknown 1 NW_019212887.1 highly similar to uniprot|Q12166 Saccharomyces cerevisiae YOR108W (ohnolog of YNL104C) LEU9 Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; 2-isopropylmalate synthase LEU4 475547 34687417 LALA0_S09e04918g Lachancea lanzarotensis 2-isopropylmalate synthase LEU4 XP_022630108.1 473718 R 1245769 CDS LALA0_S09e04940g 34687418 complement(477882..479006) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p; GTPase-activating protein RGS2 479006 34687418 LALA0_S09e04940g Lachancea lanzarotensis GTPase-activating protein RGS2 XP_022630109.1 477882 R 1245769 CDS LALA0_S09e04962g 34687419 482477..484255 Unknown 1 NW_019212887.1 weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p; uncharacterized protein 484255 34687419 LALA0_S09e04962g Lachancea lanzarotensis uncharacterized protein XP_022630110.1 482477 D 1245769 CDS LALA0_S09e04984g 34687420 complement(484321..485121) Unknown 1 NW_019212887.1 similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region; SNAP receptor VAM3 485121 34687420 LALA0_S09e04984g Lachancea lanzarotensis SNAP receptor VAM3 XP_022630111.1 484321 R 1245769 CDS LALA0_S09e05006g 34687421 485458..489885 Unknown 1 NW_019212887.1 similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; DNA-directed DNA polymerase alpha catalytic subunit POL1 489885 34687421 LALA0_S09e05006g Lachancea lanzarotensis DNA-directed DNA polymerase alpha catalytic subunit POL1 XP_022630112.1 485458 D 1245769 CDS LALA0_S09e05028g 34687422 complement(489979..490434) Unknown 1 NW_019212887.1 highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); cytosine deaminase 490434 34687422 LALA0_S09e05028g Lachancea lanzarotensis cytosine deaminase XP_022630113.1 489979 R 1245769 CDS LALA0_S09e05050g 34687423 491533..493716 Unknown 1 NW_019212887.1 similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 493716 34687423 LALA0_S09e05050g Lachancea lanzarotensis uncharacterized protein XP_022630114.1 491533 D 1245769 CDS LALA0_S09e05072g 34687424 494412..495098 Unknown 1 NW_019212887.1 similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W AIM37 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss; uncharacterized protein 495098 34687424 LALA0_S09e05072g Lachancea lanzarotensis uncharacterized protein XP_022630115.1 494412 D 1245769 CDS LALA0_S09e05094g 34687425 complement(495926..496348) Unknown 1 NW_019212887.1 some similarities with uniprot|G8ZQA3 Torulaspora delbrueckii TDEL_0B06680 hypothetical protein; uncharacterized protein 496348 34687425 LALA0_S09e05094g Lachancea lanzarotensis uncharacterized protein XP_022630116.1 495926 R 1245769 CDS LALA0_S09e05116g 34687426 complement(497359..497964) Unknown 1 NW_019212887.1 similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA; uncharacterized protein 497964 34687426 LALA0_S09e05116g Lachancea lanzarotensis uncharacterized protein XP_022630117.1 497359 R 1245769 CDS LALA0_S09e05138g 34687427 499224..499604 Unknown 1 NW_019212887.1 similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide-protein glycotransferase 499604 34687427 LALA0_S09e05138g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_022630118.1 499224 D 1245769 CDS LALA0_S09e05160g 34687428 complement(join(500088..500900,501180..501194)) Unknown 1 NW_019212887.1 similar to uniprot|P01119 Saccharomyces cerevisiae YOR101W (ohnolog of YNL098C) RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; Ras family GTPase RAS2 501194 34687428 LALA0_S09e05160g Lachancea lanzarotensis Ras family GTPase RAS2 XP_022630119.1 500088 R 1245769 CDS LALA0_S09e05182g 34687429 complement(501800..502843) Unknown 1 NW_019212887.1 similar to uniprot|P50947 Saccharomyces cerevisiae YNL097C PHO23 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3; uncharacterized protein 502843 34687429 LALA0_S09e05182g Lachancea lanzarotensis uncharacterized protein XP_022630120.1 501800 R 1245769 CDS LALA0_S09e05226g 34687431 503437..504066 Unknown 1 NW_019212887.1 similar to uniprot|Q04210 Saccharomyces cerevisiae YMR040W (ohnolog of YKL065C) YET2 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; uncharacterized protein 504066 34687431 LALA0_S09e05226g Lachancea lanzarotensis uncharacterized protein XP_022630121.1 503437 D 1245769 CDS LALA0_S09e05248g 34687432 complement(504197..505225) Unknown 1 NW_019212887.1 similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C ARA2 NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 505225 34687432 LALA0_S09e05248g Lachancea lanzarotensis D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 XP_022630122.1 504197 R 1245769 CDS LALA0_S09e05270g 34687433 505446..506351 Unknown 1 NW_019212887.1 similar to uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; chromatin-binding transcription coactivator SUB1 506351 34687433 LALA0_S09e05270g Lachancea lanzarotensis chromatin-binding transcription coactivator SUB1 XP_022630123.1 505446 D 1245769 CDS LALA0_S09e05292g 34687434 507138..509960 Unknown 1 NW_019212887.1 similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W MNR2 Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; uncharacterized protein 509960 34687434 LALA0_S09e05292g Lachancea lanzarotensis uncharacterized protein XP_022630124.1 507138 D 1245769 CDS LALA0_S09e05314g 34687435 510225..510959 Unknown 1 NW_019212887.1 similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; copper chaperone CCS1 510959 34687435 LALA0_S09e05314g Lachancea lanzarotensis copper chaperone CCS1 XP_022630125.1 510225 D 1245769 CDS LALA0_S09e05336g 34687436 complement(511295..511975) Unknown 1 NW_019212887.1 some similarities with uniprot|P35725 Saccharomyces cerevisiae YKL063C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi; uncharacterized protein 511975 34687436 LALA0_S09e05336g Lachancea lanzarotensis uncharacterized protein XP_022630126.1 511295 R 1245769 CDS LALA0_S09e05358g 34687437 514418..516403 Unknown 1 NW_019212887.1 weakly similar to uniprot|P33748 Saccharomyces cerevisiae YMR037C (ohnolog of YKL062W) MSN2 Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; uncharacterized protein 516403 34687437 LALA0_S09e05358g Lachancea lanzarotensis uncharacterized protein XP_022630127.1 514418 D 1245769 CDS LALA0_S09e05380g 34687438 516667..518496 Unknown 1 NW_019212887.1 similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring; serine/threonine protein kinase ELM1 518496 34687438 LALA0_S09e05380g Lachancea lanzarotensis serine/threonine protein kinase ELM1 XP_022630128.1 516667 D 1245769 CDS LALA0_S09e05402g 34687439 519300..520949 Unknown 1 NW_019212887.1 weakly similar to uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25; uncharacterized protein 520949 34687439 LALA0_S09e05402g Lachancea lanzarotensis uncharacterized protein XP_022630129.1 519300 D 1245769 CDS LALA0_S09e05424g 34687440 complement(521124..521654) Unknown 1 NW_019212887.1 similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p; endopeptidase catalytic subunit 521654 34687440 LALA0_S09e05424g Lachancea lanzarotensis endopeptidase catalytic subunit XP_022630130.1 521124 R 1245769 CDS LALA0_S09e05446g 34687441 complement(join(522101..523432,523509..523538)) Unknown 1 NW_019212887.1 similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; uncharacterized protein 523538 34687441 LALA0_S09e05446g Lachancea lanzarotensis uncharacterized protein XP_022630131.1 522101 R 1245769 CDS LALA0_S09e05468g 34687442 523697..524236 Unknown 1 NW_019212887.1 similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; centromeric DNA-binding histone H3-like protein CSE4 524236 34687442 LALA0_S09e05468g Lachancea lanzarotensis centromeric DNA-binding histone H3-like protein CSE4 XP_022630132.1 523697 D 1245769 CDS LALA0_S09e05490g 34687443 complement(524350..526239) Unknown 1 NW_019212887.1 similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p; formin-binding protein HOF1 526239 34687443 LALA0_S09e05490g Lachancea lanzarotensis formin-binding protein HOF1 XP_022630133.1 524350 R 1245769 CDS LALA0_S09e05512g 34687444 528241..530916 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C (ohnolog of YKL050C) EIS1 Component of the eisosome that is required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; uncharacterized protein 530916 34687444 LALA0_S09e05512g Lachancea lanzarotensis uncharacterized protein XP_022630134.1 528241 D 1245769 CDS LALA0_S09e05534g 34687445 complement(531156..532115) Unknown 1 NW_019212887.1 similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W SFK1 Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane; uncharacterized protein 532115 34687445 LALA0_S09e05534g Lachancea lanzarotensis uncharacterized protein XP_022630135.1 531156 R 1245769 CDS LALA0_S09e05556g 34687446 534895..535734 Unknown 1 NW_019212887.1 similar to uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; uncharacterized protein 535734 34687446 LALA0_S09e05556g Lachancea lanzarotensis uncharacterized protein XP_022630136.1 534895 D 1245769 CDS LALA0_S09e05578g 34687447 535884..536144 Unknown 1 NW_019212887.1 highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 536144 34687447 LALA0_S09e05578g Lachancea lanzarotensis uncharacterized protein XP_022630137.1 535884 D 1245769 CDS LALA0_S09e05600g 34687448 537340..539517 Unknown 1 NW_019212887.1 weakly similar to uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis; DNA damage-responsive RNA polymerase-degradation factor DEF1 539517 34687448 LALA0_S09e05600g Lachancea lanzarotensis DNA damage-responsive RNA polymerase-degradation factor DEF1 XP_022630138.1 537340 D 1245769 CDS LALA0_S09e05622g 34687449 539824..540627 Unknown 1 NW_019212887.1 similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) 540627 34687449 LALA0_S09e05622g Lachancea lanzarotensis 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) XP_022630139.1 539824 D 1245769 CDS LALA0_S09e05644g 34687450 541067..541570 Unknown 1 NW_019212887.1 highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C TMA19 Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; uncharacterized protein 541570 34687450 LALA0_S09e05644g Lachancea lanzarotensis uncharacterized protein XP_022630140.1 541067 D 1245769 CDS LALA0_S09e05666g 34687451 542078..543811 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p; uncharacterized protein 543811 34687451 LALA0_S09e05666g Lachancea lanzarotensis uncharacterized protein XP_022630141.1 542078 D 1245769 CDS LALA0_S09e05688g 34687452 544718..547810 Unknown 1 NW_019212887.1 similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; the Nup84 subcomplex has a role in transcription elongation; uncharacterized protein 547810 34687452 LALA0_S09e05688g Lachancea lanzarotensis uncharacterized protein XP_022630142.1 544718 D 1245769 CDS LALA0_S09e05710g 34687453 complement(547892..548986) Unknown 1 NW_019212887.1 similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; uncharacterized protein 548986 34687453 LALA0_S09e05710g Lachancea lanzarotensis uncharacterized protein XP_022630143.1 547892 R 1245769 CDS LALA0_S09e05732g 34687454 complement(549114..549464) Unknown 1 NW_019212887.1 similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; transcription initiation factor IIA subunit gamma 549464 34687454 LALA0_S09e05732g Lachancea lanzarotensis transcription initiation factor IIA subunit gamma XP_022630144.1 549114 R 1245769 CDS LALA0_S09e05754g 34687455 550210..551400 Unknown 1 NW_019212887.1 similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif; cleavage polyadenylation factor subunit MPE1 551400 34687455 LALA0_S09e05754g Lachancea lanzarotensis cleavage polyadenylation factor subunit MPE1 XP_022630145.1 550210 D 1245769 CDS LALA0_S09e05776g 34687456 complement(551428..552807) Unknown 1 NW_019212887.1 similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene; uncharacterized protein 552807 34687456 LALA0_S09e05776g Lachancea lanzarotensis uncharacterized protein XP_022630146.1 551428 R 1245769 CDS LALA0_S09e05798g 34687457 554097..555182 Unknown 1 NW_019212887.1 highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; fructose-bisphosphate aldolase FBA1 555182 34687457 LALA0_S09e05798g Lachancea lanzarotensis fructose-bisphosphate aldolase FBA1 XP_022630147.1 554097 D 1245769 CDS LALA0_S09e05820g 34687458 556061..558004 Unknown 1 NW_019212887.1 weakly similar to uniprot|Q6CRU7 Kluyveromyces lactis hypothetical protein; uncharacterized protein 558004 34687458 LALA0_S09e05820g Lachancea lanzarotensis uncharacterized protein XP_022630148.1 556061 D 1245769 CDS LALA0_S09e05842g 34687459 complement(559146..561404) Unknown 1 NW_019212887.1 similar to uniprot|G8ZQA3 Torulaspora delbrueckii TDEL_0B06680 hypothetical protein; uncharacterized protein 561404 34687459 LALA0_S09e05842g Lachancea lanzarotensis uncharacterized protein XP_022630149.1 559146 R 1245769 CDS LALA0_S09e05864g 34687460 563304..565232 Unknown 1 NW_019212887.1 weakly similar to uniprot|G8JP94 Eremothecium cymbalariae Ecym_2420 hypothetical protein; uncharacterized protein 565232 34687460 LALA0_S09e05864g Lachancea lanzarotensis uncharacterized protein XP_022630150.1 563304 D 1245769 CDS LALA0_S09e05886g 34687461 complement(565849..566160) Unknown 1 NW_019212887.1 some similarities with uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; histone H4 566160 34687461 LALA0_S09e05886g Lachancea lanzarotensis histone H4 XP_022630151.1 565849 R 1245769 CDS LALA0_S09e05908g 34687462 566806..567216 Unknown 1 NW_019212887.1 some similarities with uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; histone H3 567216 34687462 LALA0_S09e05908g Lachancea lanzarotensis histone H3 XP_022630152.1 566806 D 1245769 CDS LALA0_S09e05930g 34687463 567641..568312 Unknown 1 NW_019212887.1 similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); phosphoribosylanthranilate isomerase TRP1 568312 34687463 LALA0_S09e05930g Lachancea lanzarotensis phosphoribosylanthranilate isomerase TRP1 XP_022630153.1 567641 D 1245769 CDS LALA0_S09e05952g 34687464 complement(568393..569256) Unknown 1 NW_019212887.1 highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase; inorganic diphosphatase IPP1 569256 34687464 LALA0_S09e05952g Lachancea lanzarotensis inorganic diphosphatase IPP1 XP_022630154.1 568393 R 1245769 CDS LALA0_S09e05974g 34687465 complement(569812..570516) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W (ohnolog of YBR005W) RCR2 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p; uncharacterized protein 570516 34687465 LALA0_S09e05974g Lachancea lanzarotensis uncharacterized protein XP_022630155.1 569812 R 1245769 CDS LALA0_S09e05996g 34687466 570743..572035 Unknown 1 NW_019212887.1 similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria; GPI-anchor transamidase GPI18 572035 34687466 LALA0_S09e05996g Lachancea lanzarotensis GPI-anchor transamidase GPI18 XP_022630156.1 570743 D 1245769 CDS LALA0_S09e06018g 34687467 complement(572267..573676) Unknown 1 NW_019212887.1 highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; trans-hexaprenyltranstransferase 573676 34687467 LALA0_S09e06018g Lachancea lanzarotensis trans-hexaprenyltranstransferase XP_022630157.1 572267 R 1245769 CDS LALA0_S09e06040g 34687468 573793..574650 Unknown 1 NW_019212887.1 similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; ditrans,polycis-polyprenyl diphosphate synthase 574650 34687468 LALA0_S09e06040g Lachancea lanzarotensis ditrans,polycis-polyprenyl diphosphate synthase XP_022630158.1 573793 D 1245769 CDS LALA0_S09e06062g 34687469 complement(574837..575451) Unknown 1 NW_019212887.1 highly similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1; Ran GTPase-binding protein YRB1 575451 34687469 LALA0_S09e06062g Lachancea lanzarotensis Ran GTPase-binding protein YRB1 XP_022630159.1 574837 R 1245769 CDS LALA0_S09e06084g 34687470 575758..577995 Unknown 1 NW_019212887.1 highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C (ohnolog of YBR001C) NTH1 Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; uncharacterized protein 577995 34687470 LALA0_S09e06084g Lachancea lanzarotensis uncharacterized protein XP_022630160.1 575758 D 1245769 CDS LALA0_S09e06128g 34687471 join(578936..578977,579042..579311) Unknown 1 NW_019212887.1 highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis; uncharacterized protein 579311 34687471 LALA0_S09e06128g Lachancea lanzarotensis uncharacterized protein XP_022630161.1 578936 D 1245769 CDS LALA0_S09e06150g 34687472 complement(579516..579914) Unknown 1 NW_019212887.1 highly similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; histone H2B 579914 34687472 LALA0_S09e06150g Lachancea lanzarotensis histone H2B XP_022630162.1 579516 R 1245769 CDS LALA0_S09e06172g 34687473 580564..580962 Unknown 1 NW_019212887.1 highly similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; histone H2A 580962 34687473 LALA0_S09e06172g Lachancea lanzarotensis histone H2A XP_022630163.1 580564 D 1245769 CDS LALA0_S09e06194g 34687474 complement(581161..582375) Unknown 1 NW_019212887.1 highly similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation; uncharacterized protein 582375 34687474 LALA0_S09e06194g Lachancea lanzarotensis uncharacterized protein XP_022630164.1 581161 R 1245769 CDS LALA0_S09e06216g 34687475 582616..583227 Unknown 1 NW_019212887.1 similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair; uncharacterized protein 583227 34687475 LALA0_S09e06216g Lachancea lanzarotensis uncharacterized protein XP_022630165.1 582616 D 1245769 CDS LALA0_S09e06238g 34687476 complement(583374..590828) Unknown 1 NW_019212887.1 similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA; uncharacterized protein 590828 34687476 LALA0_S09e06238g Lachancea lanzarotensis uncharacterized protein XP_022630166.1 583374 R 1245769 CDS LALA0_S09e06260g 34687477 complement(591121..592893) Unknown 1 NW_019212887.1 similar to uniprot|Q05325 Saccharomyces cerevisiae YDL003W MCD1 Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase; kleisin alpha 592893 34687477 LALA0_S09e06260g Lachancea lanzarotensis kleisin alpha XP_022630167.1 591121 R 1245769 CDS LALA0_S09e06282g 34687478 complement(593410..593886) Unknown 1 NW_019212887.1 highly similar to uniprot|Q12165 Saccharomyces cerevisiae YDL004W ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; F1F0 ATP synthase subunit delta 593886 34687478 LALA0_S09e06282g Lachancea lanzarotensis F1F0 ATP synthase subunit delta XP_022630168.1 593410 R 1245769 CDS LALA0_S09e06304g 34687479 594326..595228 Unknown 1 NW_019212887.1 some similarities with uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; uncharacterized protein 595228 34687479 LALA0_S09e06304g Lachancea lanzarotensis uncharacterized protein XP_022630169.1 594326 D 1245769 CDS LALA0_S09e06326g 34687480 complement(595332..596219) Unknown 1 NW_019212887.1 highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; type 2C protein phosphatase PTC1 596219 34687480 LALA0_S09e06326g Lachancea lanzarotensis type 2C protein phosphatase PTC1 XP_022630170.1 595332 R 1245769 CDS LALA0_S09e06348g 34687481 complement(join(596738..598042,598145..598147)) Unknown 1 NW_019212887.1 highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; proteasome regulatory particle base subunit RPT2 598147 34687481 LALA0_S09e06348g Lachancea lanzarotensis proteasome regulatory particle base subunit RPT2 XP_022630171.1 596738 R 1245769 CDS LALA0_S09e06392g 34687483 complement(599065..601269) Unknown 1 NW_019212887.1 similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; uncharacterized protein 601269 34687483 LALA0_S09e06392g Lachancea lanzarotensis uncharacterized protein XP_022630172.1 599065 R 1245769 CDS LALA0_S09e06414g 34687484 complement(602051..603091) Unknown 1 NW_019212887.1 similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C AIM45 Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; uncharacterized protein 603091 34687484 LALA0_S09e06414g Lachancea lanzarotensis uncharacterized protein XP_022630173.1 602051 R 1245769 CDS LALA0_S09e06436g 34687485 604291..605340 Unknown 1 NW_019212887.1 similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W YFH7 Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; uncharacterized protein 605340 34687485 LALA0_S09e06436g Lachancea lanzarotensis uncharacterized protein XP_022630174.1 604291 D 1245769 CDS LALA0_S09e06458g 34687486 complement(605741..607747) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p; uncharacterized protein 607747 34687486 LALA0_S09e06458g Lachancea lanzarotensis uncharacterized protein XP_022630175.1 605741 R 1245769 CDS LALA0_S09e06480g 34687487 608065..608667 Unknown 1 NW_019212887.1 similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; uncharacterized protein 608667 34687487 LALA0_S09e06480g Lachancea lanzarotensis uncharacterized protein XP_022630176.1 608065 D 1245769 CDS LALA0_S09e06524g 34687489 609803..611029 Unknown 1 NW_019212887.1 highly similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; high-affinity iron permease FTR1 611029 34687489 LALA0_S09e06524g Lachancea lanzarotensis high-affinity iron permease FTR1 XP_022630177.1 609803 D 1245769 CDS LALA0_S09e06546g 34687490 612801..614603 Unknown 1 NW_019212887.1 weakly similar to uniprot|P15315 Saccharomyces cerevisiae YGL166W (ohnolog of YPR008W) CUP2 Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; uncharacterized protein 614603 34687490 LALA0_S09e06546g Lachancea lanzarotensis uncharacterized protein XP_022630178.1 612801 D 1245769 CDS LALA0_S09e06568g 34687491 complement(614810..616060) Unknown 1 NW_019212887.1 similar to uniprot|P53107 Saccharomyces cerevisiae YGL164C YRB30 RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes; uncharacterized protein 616060 34687491 LALA0_S09e06568g Lachancea lanzarotensis uncharacterized protein XP_022630179.1 614810 R 1245769 CDS LALA0_S09e06590g 34687492 complement(616174..618924) Unknown 1 NW_019212887.1 similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; DNA-dependent ATPase RAD54 618924 34687492 LALA0_S09e06590g Lachancea lanzarotensis DNA-dependent ATPase RAD54 XP_022630180.1 616174 R 1245769 CDS LALA0_S09e06612g 34687493 623536..624390 Unknown 1 NW_019212887.1 weakly similar to uniprot|P53032 Saccharomyces cerevisiae YGL162W (ohnolog of YPR009W) SUT1 Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; uncharacterized protein 624390 34687493 LALA0_S09e06612g Lachancea lanzarotensis uncharacterized protein XP_022630181.1 623536 D 1245769 CDS LALA0_S09e06634g 34687494 complement(625545..626327) Unknown 1 NW_019212887.1 weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; uncharacterized protein 626327 34687494 LALA0_S09e06634g Lachancea lanzarotensis uncharacterized protein XP_022630182.1 625545 R 1245769 CDS LALA0_S09e06678g 34687496 628075..629280 Unknown 1 NW_019212887.1 similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; threonylcarbamoyladenylate synthase 629280 34687496 LALA0_S09e06678g Lachancea lanzarotensis threonylcarbamoyladenylate synthase XP_022630183.1 628075 D 1245769 CDS LALA0_S09e06700g 34687497 complement(629310..632129) Unknown 1 NW_019212887.1 highly similar to uniprot|P13586 Saccharomyces cerevisiae YGL167C PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 632129 34687497 LALA0_S09e06700g Lachancea lanzarotensis Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 XP_022630184.1 629310 R 1245769 CDS LALA0_S09e06722g 34687498 complement(632600..636193) Unknown 1 NW_019212887.1 highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I second largest subunit A135; DNA-directed RNA polymerase I core subunit RPA135 636193 34687498 LALA0_S09e06722g Lachancea lanzarotensis DNA-directed RNA polymerase I core subunit RPA135 XP_022630185.1 632600 R 1245769 CDS LALA0_S09e06766g 34687500 637856..638881 Unknown 1 NW_019212887.1 similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C (ohnolog of YMR305C) SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; uncharacterized protein 638881 34687500 LALA0_S09e06766g Lachancea lanzarotensis uncharacterized protein XP_022630186.1 637856 D 1245769 CDS LALA0_S09e06788g 34687501 639800..640981 Unknown 1 NW_019212887.1 similar to uniprot|P53214 Saccharomyces cerevisiae YGR023W (ohnolog of YLR332W) MTL1 Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; uncharacterized protein 640981 34687501 LALA0_S09e06788g Lachancea lanzarotensis uncharacterized protein XP_022630187.1 639800 D 1245769 CDS LALA0_S09e06832g 34687503 641724..642818 Unknown 1 NW_019212887.1 similar to uniprot|C5DNI6 Lachancea thermotolerans KLTH0G17358g hypothetical protein; uncharacterized protein 642818 34687503 LALA0_S09e06832g Lachancea lanzarotensis uncharacterized protein XP_022630188.1 641724 D 1245769 CDS LALA0_S09e06854g 34687504 complement(642836..643612) Unknown 1 NW_019212887.1 highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes; tRNA guanylyltransferase 643612 34687504 LALA0_S09e06854g Lachancea lanzarotensis tRNA guanylyltransferase XP_022630189.1 642836 R 1245769 CDS LALA0_S09e06876g 34687505 644659..645849 Unknown 1 NW_019212887.1 highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids; ketol-acid reductoisomerase 645849 34687505 LALA0_S09e06876g Lachancea lanzarotensis ketol-acid reductoisomerase XP_022630190.1 644659 D 1245769 CDS LALA0_S09e06898g 34687506 648434..650278 Unknown 1 NW_019212887.1 some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; uncharacterized protein 650278 34687506 LALA0_S09e06898g Lachancea lanzarotensis uncharacterized protein XP_022630191.1 648434 D 1245769 CDS LALA0_S09e06920g 34687507 652467..655982 Unknown 1 NW_019212887.1 similar to uniprot|C5DG58 Lachancea thermotolerans KLTH0D02596g hypothetical protein; uncharacterized protein 655982 34687507 LALA0_S09e06920g Lachancea lanzarotensis uncharacterized protein XP_022630192.1 652467 D 1245769 CDS LALA0_S09e06942g 34687508 complement(656594..656920) Unknown 1 NW_019212887.1 similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; ribosomal protein P2 alpha 656920 34687508 LALA0_S09e06942g Lachancea lanzarotensis ribosomal protein P2 alpha XP_022630193.1 656594 R 1245769 CDS LALA0_S09e06964g 34687509 657624..658049 Unknown 1 NW_019212887.1 highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C RPS15 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins; 40S ribosomal protein uS19 658049 34687509 LALA0_S09e06964g Lachancea lanzarotensis 40S ribosomal protein uS19 XP_022630194.1 657624 D 1245769 CDS LALA0_S09e06986g 34687510 complement(join(658319..660351,660440..660467)) Unknown 1 NW_019212887.1 some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation; Rpd3L histone deacetylase complex subunit DEP1 660467 34687510 LALA0_S09e06986g Lachancea lanzarotensis Rpd3L histone deacetylase complex subunit DEP1 XP_022630195.1 658319 R 1245769 CDS LALA0_S09e07008g 34687511 662147..663556 Unknown 1 NW_019212887.1 similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C NOP12 Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p; uncharacterized protein 663556 34687511 LALA0_S09e07008g Lachancea lanzarotensis uncharacterized protein XP_022630196.1 662147 D 1245769 CDS LALA0_S09e07030g 34687512 664219..665052 Unknown 1 NW_019212887.1 similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8; syntaxin 665052 34687512 LALA0_S09e07030g Lachancea lanzarotensis syntaxin XP_022630197.1 664219 D 1245769 CDS LALA0_S09e07052g 34687513 complement(665327..665827) Unknown 1 NW_019212887.1 weakly similar to uniprot|C5DG58 Lachancea thermotolerans KLTH0D02596g hypothetical protein; uncharacterized protein 665827 34687513 LALA0_S09e07052g Lachancea lanzarotensis uncharacterized protein XP_022630198.1 665327 R 1245769 CDS LALA0_S09e07074g 34687514 complement(666744..667838) Unknown 1 NW_019212887.1 similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W NGL1 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RNA exonuclease 667838 34687514 LALA0_S09e07074g Lachancea lanzarotensis RNA exonuclease XP_022630199.1 666744 R 1245769 CDS LALA0_S09e07096g 34687515 669025..670170 Unknown 1 NW_019212887.1 similar to uniprot|P31378 Saccharomyces cerevisiae YAL015C (ohnolog of YOL043C) NTG1 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; uncharacterized protein 670170 34687515 LALA0_S09e07096g Lachancea lanzarotensis uncharacterized protein XP_022630200.1 669025 D 1245769 CDS LALA0_S09e07118g 34687516 complement(670338..672272) Unknown 1 NW_019212887.1 highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III; protein phosphatase 2A structural subunit TPD3 672272 34687516 LALA0_S09e07118g Lachancea lanzarotensis protein phosphatase 2A structural subunit TPD3 XP_022630201.1 670338 R 1245769 CDS LALA0_S09e07140g 34687517 complement(672574..673662) Unknown 1 NW_019212887.1 weakly similar to uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly; uncharacterized protein 673662 34687517 LALA0_S09e07140g Lachancea lanzarotensis uncharacterized protein XP_022630202.1 672574 R 1245769 CDS LALA0_S09e07162g 34687518 complement(674027..677710) Unknown 1 NW_019212887.1 similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W (ohnolog of YOL045W) PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; uncharacterized protein 677710 34687518 LALA0_S09e07162g Lachancea lanzarotensis uncharacterized protein XP_022630203.1 674027 R 1245769 CDS LALA0_S09e07184g 34687519 join(679637..679861,679948..680706) Unknown 1 NW_019212887.1 similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function; uncharacterized protein 680706 34687519 LALA0_S09e07184g Lachancea lanzarotensis uncharacterized protein XP_022630204.1 679637 D 1245769 CDS LALA0_S09e07206g 34687520 681227..681943 Unknown 1 NW_019212887.1 weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function; uncharacterized protein 681943 34687520 LALA0_S09e07206g Lachancea lanzarotensis uncharacterized protein XP_022630205.1 681227 D 1245769 CDS LALA0_S09e07228g 34687521 join(682147..682353,682434..683141) Unknown 1 NW_019212887.1 weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function; uncharacterized protein 683141 34687521 LALA0_S09e07228g Lachancea lanzarotensis uncharacterized protein XP_022630206.1 682147 D 1245769 CDS LALA0_S09e07250g 34687522 complement(683172..684635) Unknown 1 NW_019212887.1 similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock; glutathione synthase 684635 34687522 LALA0_S09e07250g Lachancea lanzarotensis glutathione synthase XP_022630207.1 683172 R 1245769 CDS LALA0_S09e07272g 34687523 complement(686288..690211) Unknown 1 NW_019212887.1 weakly similar to uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator; uncharacterized protein 690211 34687523 LALA0_S09e07272g Lachancea lanzarotensis uncharacterized protein XP_022630208.1 686288 R 1245769 CDS LALA0_S09e07294g 34687524 complement(690961..694134) Unknown 1 NW_019212887.1 similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; DNA-dependent ATPase FUN30 694134 34687524 LALA0_S09e07294g Lachancea lanzarotensis DNA-dependent ATPase FUN30 XP_022630209.1 690961 R 1245769 CDS LALA0_S09e07316g 34687525 694724..695755 Unknown 1 NW_019212887.1 weakly similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle; uncharacterized protein 695755 34687525 LALA0_S09e07316g Lachancea lanzarotensis uncharacterized protein XP_022630210.1 694724 D 1245769 CDS LALA0_S09e07338g 34687526 697203..699740 Unknown 1 NW_019212887.1 weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 699740 34687526 LALA0_S09e07338g Lachancea lanzarotensis uncharacterized protein XP_022630211.1 697203 D 1245769 CDS LALA0_S09e07360g 34687527 700219..702465 Unknown 1 NW_019212887.1 similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C LDB19 Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye; uncharacterized protein 702465 34687527 LALA0_S09e07360g Lachancea lanzarotensis uncharacterized protein XP_022630212.1 700219 D 1245769 CDS LALA0_S09e07382g 34687528 complement(702613..704844) Unknown 1 NW_019212887.1 highly similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C (ohnolog of YOR321W) PMT2 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal; dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 704844 34687528 LALA0_S09e07382g Lachancea lanzarotensis dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 XP_022630213.1 702613 R 1245769 CDS LALA0_S09e07404g 34687529 complement(705360..706655) Unknown 1 NW_019212887.1 similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; nucleoside transmembrane transporter FUN26 706655 34687529 LALA0_S09e07404g Lachancea lanzarotensis nucleoside transmembrane transporter FUN26 XP_022630214.1 705360 R 1245769 CDS LALA0_S09e07426g 34687530 complement(707283..709637) Unknown 1 NW_019212887.1 similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; CCR4-NOT core exoribonuclease subunit CCR4 709637 34687530 LALA0_S09e07426g Lachancea lanzarotensis CCR4-NOT core exoribonuclease subunit CCR4 XP_022630215.1 707283 R 1245769 CDS LALA0_S09e07448g 34687531 join(711748..711828,711907..712155) Unknown 1 NW_019212887.1 highly similar to uniprot|P31109 Saccharomyces cerevisiae YAL030W (ohnolog of YOR327C) SNC1 Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; uncharacterized protein 712155 34687531 LALA0_S09e07448g Lachancea lanzarotensis uncharacterized protein XP_022630216.1 711748 D 1245769 CDS LALA0_S09e07470g 34687532 complement(712375..717096) Unknown 1 NW_019212887.1 similar to uniprot|P32492 Saccharomyces cerevisiae YAL029C (ohnolog of YOR326W) MYO4 One of two type V myosinmotors (along with MYO2) involved in actin-based transportof cargos; required for mRNA transport, including ASH1mRNA, and facilitating the growth and movement of ERtubules into the growing bud along with She3p; uncharacterized protein 717096 34687532 LALA0_S09e07470g Lachancea lanzarotensis uncharacterized protein XP_022630217.1 712375 R 1245769 CDS LALA0_S10e00100g 34687533 complement(join(1..261,265..2349)) Unknown 1 NW_019212888.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C FLO9 Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; 2349 34687533 LALA0_S10e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S10e00122g 34687534 complement(6623..8221) Unknown 1 NW_019212888.1 highly similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene; uncharacterized protein 8221 34687534 LALA0_S10e00122g Lachancea lanzarotensis uncharacterized protein XP_022630218.1 6623 R 1245769 CDS LALA0_S10e00144g 34687535 10723..11310 Unknown 1 NW_019212888.1 similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene; acetyltransferase 11310 34687535 LALA0_S10e00144g Lachancea lanzarotensis acetyltransferase XP_022630219.1 10723 D 1245769 CDS LALA0_S10e00166g 34687536 11877..12821 Unknown 1 NW_019212888.1 highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 Dihydroorotate dehydrogenase,catalyzes the fourth enzymatic step in the de novobiosynthesis of pyrimidines, converting dihydroorotic acidinto orotic acid; dihydroorotate dehydrogenase 12821 34687536 LALA0_S10e00166g Lachancea lanzarotensis dihydroorotate dehydrogenase XP_022630220.1 11877 D 1245769 CDS LALA0_S10e00188g 34687537 complement(13371..14132) Unknown 1 NW_019212888.1 similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 14132 34687537 LALA0_S10e00188g Lachancea lanzarotensis uncharacterized protein XP_022630221.1 13371 R 1245769 CDS LALA0_S10e00210g 34687538 15409..16203 Unknown 1 NW_019212888.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH; uncharacterized protein 16203 34687538 LALA0_S10e00210g Lachancea lanzarotensis uncharacterized protein XP_022630222.1 15409 D 1245769 CDS LALA0_S10e00232g 34687539 complement(16876..17985) Unknown 1 NW_019212888.1 some similarities with uniprot|Q751S6 Ashbya gossypii AGL345Wp hypothetical protein; 17985 34687539 LALA0_S10e00232g Lachancea lanzarotensis 16876 R 1245769 CDS LALA0_S10e00254g 34687540 21569..23245 Unknown 1 NW_019212888.1 weakly similar to uniprot|C5DEV0 Lachancea thermotolerans KLTH0D09966g hypothetical protein; uncharacterized protein 23245 34687540 LALA0_S10e00254g Lachancea lanzarotensis uncharacterized protein XP_022630223.1 21569 D 1245769 CDS LALA0_S10e00276g 34687541 complement(23499..25994) Unknown 1 NW_019212888.1 similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection; translation initiation factor eIF3 core subunit c 25994 34687541 LALA0_S10e00276g Lachancea lanzarotensis translation initiation factor eIF3 core subunit c XP_022630224.1 23499 R 1245769 CDS LALA0_S10e00298g 34687542 complement(27473..28393) Unknown 1 NW_019212888.1 highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance; glucan 1,3-beta-glucosidase 28393 34687542 LALA0_S10e00298g Lachancea lanzarotensis glucan 1,3-beta-glucosidase XP_022630225.1 27473 R 1245769 CDS LALA0_S10e00320g 34687543 complement(29514..30686) Unknown 1 NW_019212888.1 similar to uniprot|P53336 Saccharomyces cerevisiae YGR283C (ohnolog of YMR310C) Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; uncharacterized protein 30686 34687543 LALA0_S10e00320g Lachancea lanzarotensis uncharacterized protein XP_022630226.1 29514 R 1245769 CDS LALA0_S10e00342g 34687544 complement(30914..31531) Unknown 1 NW_019212888.1 similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; uncharacterized protein 31531 34687544 LALA0_S10e00342g Lachancea lanzarotensis uncharacterized protein XP_022630227.1 30914 R 1245769 CDS LALA0_S10e00364g 34687545 complement(32071..32988) Unknown 1 NW_019212888.1 highly similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; uncharacterized protein 32988 34687545 LALA0_S10e00364g Lachancea lanzarotensis uncharacterized protein XP_022630228.1 32071 R 1245769 CDS LALA0_S10e00386g 34687546 complement(33721..35007) Unknown 1 NW_019212888.1 highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; zuotin 35007 34687546 LALA0_S10e00386g Lachancea lanzarotensis zuotin XP_022630229.1 33721 R 1245769 CDS LALA0_S10e00408g 34687547 35359..36201 Unknown 1 NW_019212888.1 similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; Elongator subunit ELP6 36201 34687547 LALA0_S10e00408g Lachancea lanzarotensis Elongator subunit ELP6 XP_022630230.1 35359 D 1245769 CDS LALA0_S10e00430g 34687548 complement(36232..37974) Unknown 1 NW_019212888.1 similar to uniprot|P40308 Saccharomyces cerevisiae YMR313C TGL3 Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation; bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase 37974 34687548 LALA0_S10e00430g Lachancea lanzarotensis bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase XP_022630231.1 36232 R 1245769 CDS LALA0_S10e00452g 34687549 39116..39817 Unknown 1 NW_019212888.1 highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 Alpha 6 subunit of the 20S proteasome; proteasome core particle subunit alpha 6 39817 34687549 LALA0_S10e00452g Lachancea lanzarotensis proteasome core particle subunit alpha 6 XP_022630232.1 39116 D 1245769 CDS LALA0_S10e00474g 34687550 40251..42362 Unknown 1 NW_019212888.1 highly similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; ATP-binding cassette Fe/S cluster precursor transporter ATM1 42362 34687550 LALA0_S10e00474g Lachancea lanzarotensis ATP-binding cassette Fe/S cluster precursor transporter ATM1 XP_022630233.1 40251 D 1245769 CDS LALA0_S10e00496g 34687551 43329..44861 Unknown 1 NW_019212888.1 highly similar to uniprot|P04046 Saccharomyces cerevisiae YMR300C ADE4 Phosphoribosylpyrophosphateamidotransferase (PRPPAT; amidophosphoribosyltransferase),catalyzes first step of the 'de novo' purine nucleotidebiosynthetic pathway; amidophosphoribosyltransferase 44861 34687551 LALA0_S10e00496g Lachancea lanzarotensis amidophosphoribosyltransferase XP_022630234.1 43329 D 1245769 CDS LALA0_S10e00518g 34687552 45156..46181 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration; dynein light intermediate chain 46181 34687552 LALA0_S10e00518g Lachancea lanzarotensis dynein light intermediate chain XP_022630235.1 45156 D 1245769 CDS LALA0_S10e00540g 34687553 46690..48648 Unknown 1 NW_019212888.1 similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; uncharacterized protein 48648 34687553 LALA0_S10e00540g Lachancea lanzarotensis uncharacterized protein XP_022630236.1 46690 D 1245769 CDS LALA0_S10e00562g 34687554 complement(49366..49947) Unknown 1 NW_019212888.1 weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; uncharacterized protein 49947 34687554 LALA0_S10e00562g Lachancea lanzarotensis uncharacterized protein XP_022630237.1 49366 R 1245769 CDS LALA0_S10e00584g 34687555 51273..54305 Unknown 1 NW_019212888.1 similar to uniprot|P46677 Saccharomyces cerevisiae YGR274C TAF1 TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; histone acetyltransferase 54305 34687555 LALA0_S10e00584g Lachancea lanzarotensis histone acetyltransferase XP_022630238.1 51273 D 1245769 CDS LALA0_S10e00606g 34687556 complement(54400..54822) Unknown 1 NW_019212888.1 similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W LIP1 Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis; sphingosine N-acyltransferase subunit LIP1 54822 34687556 LALA0_S10e00606g Lachancea lanzarotensis sphingosine N-acyltransferase subunit LIP1 XP_022630239.1 54400 R 1245769 CDS LALA0_S10e00628g 34687557 complement(55251..56831) Unknown 1 NW_019212888.1 similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; carboxypeptidase C PRC1 56831 34687557 LALA0_S10e00628g Lachancea lanzarotensis carboxypeptidase C PRC1 XP_022630240.1 55251 R 1245769 CDS LALA0_S10e00650g 34687558 58382..60040 Unknown 1 NW_019212888.1 similar to uniprot|P25045 Saccharomyces cerevisiae YMR296C LCB1 Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; serine C-palmitoyltransferase LCB1 60040 34687558 LALA0_S10e00650g Lachancea lanzarotensis serine C-palmitoyltransferase LCB1 XP_022630241.1 58382 D 1245769 CDS LALA0_S10e00672g 34687559 complement(60200..61246) Unknown 1 NW_019212888.1 weakly similar to uniprot|P53047 Saccharomyces cerevisiae YGR213C (ohnolog of YLR046C) RTA1 Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; uncharacterized protein 61246 34687559 LALA0_S10e00672g Lachancea lanzarotensis uncharacterized protein XP_022630242.1 60200 R 1245769 CDS LALA0_S10e00694g 34687560 63697..64257 Unknown 1 NW_019212888.1 similar to uniprot|P53329 Saccharomyces cerevisiae YGR273C (ohnolog of YMR295C) Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene; uncharacterized protein 64257 34687560 LALA0_S10e00694g Lachancea lanzarotensis uncharacterized protein XP_022630243.1 63697 D 1245769 CDS LALA0_S10e00716g 34687561 65296..65994 Unknown 1 NW_019212888.1 similar to uniprot|Q3E705 Saccharomyces cerevisiae YGR271C-A EFG1 Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; uncharacterized protein 65994 34687561 LALA0_S10e00716g Lachancea lanzarotensis uncharacterized protein XP_022630244.1 65296 D 1245769 CDS LALA0_S10e00738g 34687562 complement(66073..71940) Unknown 1 NW_019212888.1 highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; uncharacterized protein 71940 34687562 LALA0_S10e00738g Lachancea lanzarotensis uncharacterized protein XP_022630245.1 66073 R 1245769 CDS LALA0_S10e00760g 34687563 complement(72304..73401) Unknown 1 NW_019212888.1 weakly similar to uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B; uncharacterized protein 73401 34687563 LALA0_S10e00760g Lachancea lanzarotensis uncharacterized protein XP_022630246.1 72304 R 1245769 CDS LALA0_S10e00782g 34687564 73595..75007 Unknown 1 NW_019212888.1 similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase; glutamyl-tRNA(Gln) amidotransferase subunit HER2 75007 34687564 LALA0_S10e00782g Lachancea lanzarotensis glutamyl-tRNA(Gln) amidotransferase subunit HER2 XP_022630247.1 73595 D 1245769 CDS LALA0_S10e00804g 34687565 complement(75013..79098) Unknown 1 NW_019212888.1 similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p; uncharacterized protein 79098 34687565 LALA0_S10e00804g Lachancea lanzarotensis uncharacterized protein XP_022630248.1 75013 R 1245769 CDS LALA0_S10e00826g 34687566 complement(join(79801..80195,80255..80276)) Unknown 1 NW_019212888.1 highly similar to uniprot|Q03554 Saccharomyces cerevisiae YMR292W GOT1 Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition; uncharacterized protein 80276 34687566 LALA0_S10e00826g Lachancea lanzarotensis uncharacterized protein XP_022630249.1 79801 R 1245769 CDS LALA0_S10e00848g 34687567 81628..82191 Unknown 1 NW_019212888.1 similar to uniprot|P40325 Saccharomyces cerevisiae YGR268C HUA1 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly; uncharacterized protein 82191 34687567 LALA0_S10e00848g Lachancea lanzarotensis uncharacterized protein XP_022630250.1 81628 D 1245769 CDS LALA0_S10e00870g 34687568 82426..83157 Unknown 1 NW_019212888.1 highly similar to uniprot|P51601 Saccharomyces cerevisiae YGR267C FOL2 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway; GTP cyclohydrolase I 83157 34687568 LALA0_S10e00870g Lachancea lanzarotensis GTP cyclohydrolase I XP_022630251.1 82426 D 1245769 CDS LALA0_S10e00892g 34687569 complement(83243..84745) Unknown 1 NW_019212888.1 similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W TDA1 Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; protein kinase TDA1 84745 34687569 LALA0_S10e00892g Lachancea lanzarotensis protein kinase TDA1 XP_022630252.1 83243 R 1245769 CDS LALA0_S10e00914g 34687570 complement(85776..87854) Unknown 1 NW_019212888.1 similar to uniprot|P53326 Saccharomyces cerevisiae YGR266W Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; uncharacterized protein 87854 34687570 LALA0_S10e00914g Lachancea lanzarotensis uncharacterized protein XP_022630253.1 85776 R 1245769 CDS LALA0_S10e00936g 34687571 88948..90471 Unknown 1 NW_019212888.1 highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles; ATP-dependent RNA helicase HAS1 90471 34687571 LALA0_S10e00936g Lachancea lanzarotensis ATP-dependent RNA helicase HAS1 XP_022630254.1 88948 D 1245769 CDS LALA0_S10e00958g 34687572 91233..93488 Unknown 1 NW_019212888.1 highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; methionine--tRNA ligase MES1 93488 34687572 LALA0_S10e00958g Lachancea lanzarotensis methionine--tRNA ligase MES1 XP_022630255.1 91233 D 1245769 CDS LALA0_S10e00980g 34687573 93740..94531 Unknown 1 NW_019212888.1 highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; serine/threonine protein kinase BUD32 94531 34687573 LALA0_S10e00980g Lachancea lanzarotensis serine/threonine protein kinase BUD32 XP_022630256.1 93740 D 1245769 CDS LALA0_S10e01002g 34687574 complement(94570..95721) Unknown 1 NW_019212888.1 similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis; aminodeoxychorismate lyase ABZ2 95721 34687574 LALA0_S10e01002g Lachancea lanzarotensis aminodeoxychorismate lyase ABZ2 XP_022630257.1 94570 R 1245769 CDS LALA0_S10e01046g 34687576 96962..99340 Unknown 1 NW_019212888.1 similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools; uncharacterized protein 99340 34687576 LALA0_S10e01046g Lachancea lanzarotensis uncharacterized protein XP_022630258.1 96962 D 1245769 CDS LALA0_S10e01068g 34687577 complement(99450..102437) Unknown 1 NW_019212888.1 similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; U2 snRNP complex subunit HSH155 102437 34687577 LALA0_S10e01068g Lachancea lanzarotensis U2 snRNP complex subunit HSH155 XP_022630259.1 99450 R 1245769 CDS LALA0_S10e01090g 34687578 102693..104684 Unknown 1 NW_019212888.1 similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog; GPI-anchor transamidase subunit GPI16 104684 34687578 LALA0_S10e01090g Lachancea lanzarotensis GPI-anchor transamidase subunit GPI16 XP_022630260.1 102693 D 1245769 CDS LALA0_S10e01112g 34687579 complement(105265..106164) Unknown 1 NW_019212888.1 similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; Elongator subunit IKI1 106164 34687579 LALA0_S10e01112g Lachancea lanzarotensis Elongator subunit IKI1 XP_022630261.1 105265 R 1245769 CDS LALA0_S10e01134g 34687580 108526..113082 Unknown 1 NW_019212888.1 similar to uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; ubiquitin-binding TORC1 subunit KOG1 113082 34687580 LALA0_S10e01134g Lachancea lanzarotensis ubiquitin-binding TORC1 subunit KOG1 XP_022630262.1 108526 D 1245769 CDS LALA0_S10e01178g 34687582 114080..116968 Unknown 1 NW_019212888.1 similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein; ssDNA endodeoxyribonuclease RAD2 116968 34687582 LALA0_S10e01178g Lachancea lanzarotensis ssDNA endodeoxyribonuclease RAD2 XP_022630263.1 114080 D 1245769 CDS LALA0_S10e01200g 34687583 117193..117999 Unknown 1 NW_019212888.1 weakly similar to uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation; uncharacterized protein 117999 34687583 LALA0_S10e01200g Lachancea lanzarotensis uncharacterized protein XP_022630264.1 117193 D 1245769 CDS LALA0_S10e01222g 34687584 118368..119396 Unknown 1 NW_019212888.1 similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor; uncharacterized protein 119396 34687584 LALA0_S10e01222g Lachancea lanzarotensis uncharacterized protein XP_022630265.1 118368 D 1245769 CDS LALA0_S10e01244g 34687585 complement(119520..121307) Unknown 1 NW_019212888.1 weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis; uncharacterized protein 121307 34687585 LALA0_S10e01244g Lachancea lanzarotensis uncharacterized protein XP_022630266.1 119520 R 1245769 CDS LALA0_S10e01266g 34687586 complement(121783..123261) Unknown 1 NW_019212888.1 highly similar to uniprot|P38720 Saccharomyces cerevisiae YHR183W (ohnolog of YGR256W) GND1 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; uncharacterized protein 123261 34687586 LALA0_S10e01266g Lachancea lanzarotensis uncharacterized protein XP_022630267.1 121783 R 1245769 CDS LALA0_S10e01288g 34687587 complement(124393..125874) Unknown 1 NW_019212888.1 similar to uniprot|Q04705 Saccharomyces cerevisiae YML047C (ohnolog of YJR054W) PRM6 Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating; uncharacterized protein 125874 34687587 LALA0_S10e01288g Lachancea lanzarotensis uncharacterized protein XP_022630268.1 124393 R 1245769 CDS LALA0_S10e01310g 34687588 complement(126756..128393) Unknown 1 NW_019212888.1 weakly similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis; uncharacterized protein 128393 34687588 LALA0_S10e01310g Lachancea lanzarotensis uncharacterized protein XP_022630269.1 126756 R 1245769 CDS LALA0_S10e01332g 34687589 129491..131377 Unknown 1 NW_019212888.1 similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats; uncharacterized protein 131377 34687589 LALA0_S10e01332g Lachancea lanzarotensis uncharacterized protein XP_022630270.1 129491 D 1245769 CDS LALA0_S10e01354g 34687590 complement(131394..133238) Unknown 1 NW_019212888.1 similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; UV-damaged DNA-binding protein RAD7 133238 34687590 LALA0_S10e01354g Lachancea lanzarotensis UV-damaged DNA-binding protein RAD7 XP_022630271.1 131394 R 1245769 CDS LALA0_S10e01398g 34687592 134159..135733 Unknown 1 NW_019212888.1 weakly similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4; uncharacterized protein 135733 34687592 LALA0_S10e01398g Lachancea lanzarotensis uncharacterized protein XP_022630272.1 134159 D 1245769 CDS LALA0_S10e01420g 34687593 complement(135771..136193) Unknown 1 NW_019212888.1 similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C TCA17 Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder; uncharacterized protein 136193 34687593 LALA0_S10e01420g Lachancea lanzarotensis uncharacterized protein XP_022630273.1 135771 R 1245769 CDS LALA0_S10e01442g 34687594 complement(136455..137951) Unknown 1 NW_019212888.1 similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C (ohnolog of YJR051W) Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; fumarate reductase 137951 34687594 LALA0_S10e01442g Lachancea lanzarotensis fumarate reductase XP_022630274.1 136455 R 1245769 CDS LALA0_S10e01464g 34687595 complement(138952..140127) Unknown 1 NW_019212888.1 highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; threonine aldolase GLY1 140127 34687595 LALA0_S10e01464g Lachancea lanzarotensis threonine aldolase GLY1 XP_022630275.1 138952 R 1245769 CDS LALA0_S10e01508g 34687597 141392..141781 Unknown 1 NW_019212888.1 similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; uncharacterized protein 141781 34687597 LALA0_S10e01508g Lachancea lanzarotensis uncharacterized protein XP_022630276.1 141392 D 1245769 CDS LALA0_S10e01530g 34687598 143255..145636 Unknown 1 NW_019212888.1 weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold; uncharacterized protein 145636 34687598 LALA0_S10e01530g Lachancea lanzarotensis uncharacterized protein XP_022630277.1 143255 D 1245769 CDS LALA0_S10e01552g 34687599 complement(145738..146538) Unknown 1 NW_019212888.1 similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles; uncharacterized protein 146538 34687599 LALA0_S10e01552g Lachancea lanzarotensis uncharacterized protein XP_022630278.1 145738 R 1245769 CDS LALA0_S10e01574g 34687600 147040..150567 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q06211 Saccharomyces cerevisiae YPR164W MMS1 Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay; uncharacterized protein 150567 34687600 LALA0_S10e01574g Lachancea lanzarotensis uncharacterized protein XP_022630279.1 147040 D 1245769 CDS LALA0_S10e01596g 34687601 151080..152045 Unknown 1 NW_019212888.1 similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; [acyl-carrier-protein] S-malonyltransferase 152045 34687601 LALA0_S10e01596g Lachancea lanzarotensis [acyl-carrier-protein] S-malonyltransferase XP_022630280.1 151080 D 1245769 CDS LALA0_S10e01618g 34687602 complement(152062..153132) Unknown 1 NW_019212888.1 similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole; gluconeogenesis transcription factor RDS2 153132 34687602 LALA0_S10e01618g Lachancea lanzarotensis gluconeogenesis transcription factor RDS2 XP_022630281.1 152062 R 1245769 CDS LALA0_S10e01640g 34687603 153747..154508 Unknown 1 NW_019212888.1 similar to uniprot|P19516 Saccharomyces cerevisiae YPL132W COX11 Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; uncharacterized protein 154508 34687603 LALA0_S10e01640g Lachancea lanzarotensis uncharacterized protein XP_022630282.1 153747 D 1245769 CDS LALA0_S10e01662g 34687604 complement(154620..155267) Unknown 1 NW_019212888.1 similar to uniprot|Q12044 Saccharomyces cerevisiae YOR220W RCN2 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor; uncharacterized protein 155267 34687604 LALA0_S10e01662g Lachancea lanzarotensis uncharacterized protein XP_022630283.1 154620 R 1245769 CDS LALA0_S10e01684g 34687605 156807..157694 Unknown 1 NW_019212888.1 highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly; 60S ribosomal protein uL18 157694 34687605 LALA0_S10e01684g Lachancea lanzarotensis 60S ribosomal protein uL18 XP_022630284.1 156807 D 1245769 CDS LALA0_S10e01706g 34687606 158503..161127 Unknown 1 NW_019212888.1 similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor; uncharacterized protein 161127 34687606 LALA0_S10e01706g Lachancea lanzarotensis uncharacterized protein XP_022630285.1 158503 D 1245769 CDS LALA0_S10e01728g 34687607 complement(161215..163836) Unknown 1 NW_019212888.1 similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 1 163836 34687607 LALA0_S10e01728g Lachancea lanzarotensis replication factor C subunit 1 XP_022630286.1 161215 R 1245769 CDS LALA0_S10e01750g 34687608 164758..166110 Unknown 1 NW_019212888.1 similar to uniprot|Q12234 Saccharomyces cerevisiae YOR216C RUD3 Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1; uncharacterized protein 166110 34687608 LALA0_S10e01750g Lachancea lanzarotensis uncharacterized protein XP_022630287.1 164758 D 1245769 CDS LALA0_S10e01772g 34687609 166384..166950 Unknown 1 NW_019212888.1 similar to uniprot|Q12032 Saccharomyces cerevisiae YOR215C AIM41 Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; uncharacterized protein 166950 34687609 LALA0_S10e01772g Lachancea lanzarotensis uncharacterized protein XP_022630288.1 166384 D 1245769 CDS LALA0_S10e01794g 34687610 join(167396..167404,167489..168247) Unknown 1 NW_019212888.1 highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W (ohnolog of YOR213C) TAF14 Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; uncharacterized protein 168247 34687610 LALA0_S10e01794g Lachancea lanzarotensis uncharacterized protein XP_022630289.1 167396 D 1245769 CDS LALA0_S10e01816g 34687611 join(168601..168609,168675..169325) Unknown 1 NW_019212888.1 weakly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W (ohnolog of YOR213C) TAF14 Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; uncharacterized protein 169325 34687611 LALA0_S10e01816g Lachancea lanzarotensis uncharacterized protein XP_022630290.1 168601 D 1245769 CDS LALA0_S10e01838g 34687612 complement(169374..170645) Unknown 1 NW_019212888.1 similar to uniprot|P18851 Saccharomyces cerevisiae YOR212W STE4 G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats; G protein subunit beta 170645 34687612 LALA0_S10e01838g Lachancea lanzarotensis G protein subunit beta XP_022630291.1 169374 R 1245769 CDS LALA0_S10e01860g 34687613 complement(171120..172652) Unknown 1 NW_019212888.1 weakly similar to uniprot|Q02457 Saccharomyces cerevisiae YPL128C TBF1 Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; uncharacterized protein 172652 34687613 LALA0_S10e01860g Lachancea lanzarotensis uncharacterized protein XP_022630292.1 171120 R 1245769 CDS LALA0_S10e01882g 34687614 complement(join(173554..174059,174131..174290)) Unknown 1 NW_019212888.1 weakly similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation; histone H1 174290 34687614 LALA0_S10e01882g Lachancea lanzarotensis histone H1 XP_022630293.1 173554 R 1245769 CDS LALA0_S10e01904g 34687615 175089..177680 Unknown 1 NW_019212888.1 similar to uniprot|P32266 Saccharomyces cerevisiae YOR211C MGM1 Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy; dynamin-related GTPase MGM1 177680 34687615 LALA0_S10e01904g Lachancea lanzarotensis dynamin-related GTPase MGM1 XP_022630294.1 175089 D 1245769 CDS LALA0_S10e01926g 34687616 complement(178016..178228) Unknown 1 NW_019212888.1 some similarities with uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III; DNA-directed RNA polymerase core subunit RPB10 178228 34687616 LALA0_S10e01926g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPB10 XP_022630295.1 178016 R 1245769 CDS LALA0_S10e01948g 34687617 178521..181148 Unknown 1 NW_019212888.1 similar to uniprot|Q02931 Saccharomyces cerevisiae YPL126W NAN1 U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; uncharacterized protein 181148 34687617 LALA0_S10e01948g Lachancea lanzarotensis uncharacterized protein XP_022630296.1 178521 D 1245769 CDS LALA0_S10e01970g 34687618 181377..182666 Unknown 1 NW_019212888.1 similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus; nicotinate phosphoribosyltransferase 182666 34687618 LALA0_S10e01970g Lachancea lanzarotensis nicotinate phosphoribosyltransferase XP_022630297.1 181377 D 1245769 CDS LALA0_S10e01992g 34687619 182926..186024 Unknown 1 NW_019212888.1 similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p; uncharacterized protein 186024 34687619 LALA0_S10e01992g Lachancea lanzarotensis uncharacterized protein XP_022630298.1 182926 D 1245769 CDS LALA0_S10e02014g 34687620 complement(186132..188705) Unknown 1 NW_019212888.1 weakly similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus; tyrosine protein phosphatase PTP2 188705 34687620 LALA0_S10e02014g Lachancea lanzarotensis tyrosine protein phosphatase PTP2 XP_022630299.1 186132 R 1245769 CDS LALA0_S10e02036g 34687621 190455..>191144 Unknown 1 NW_019212888.1 similar to uniprot|C5DGZ6 Lachancea thermotolerans KLTH0D09570g hypothetical protein; uncharacterized protein 191144 34687621 LALA0_S10e02036g Lachancea lanzarotensis uncharacterized protein XP_022630300.1 190455 D 1245769 CDS LALA0_S10e02058g 34687622 complement(191311..192633) Unknown 1 NW_019212888.1 similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity; ribonuclease T2 192633 34687622 LALA0_S10e02058g Lachancea lanzarotensis ribonuclease T2 XP_022630301.1 191311 R 1245769 CDS LALA0_S10e02080g 34687623 complement(193478..196096) Unknown 1 NW_019212888.1 similar to uniprot|P21672 Saccharomyces cerevisiae YIL066C (ohnolog of YER070W) RNR3 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; uncharacterized protein 196096 34687623 LALA0_S10e02080g Lachancea lanzarotensis uncharacterized protein XP_022630302.1 193478 R 1245769 CDS LALA0_S10e02102g 34687624 complement(196402..197766) Unknown 1 NW_019212888.1 similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential inautophagy and Complex II is required for vacuolar proteinsorting; ortholog of the higher eukaryotic gene Beclin 1; beclin 1 197766 34687624 LALA0_S10e02102g Lachancea lanzarotensis beclin 1 XP_022630303.1 196402 R 1245769 CDS LALA0_S10e02124g 34687625 complement(198243..199862) Unknown 1 NW_019212888.1 similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C GEP3 Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; uncharacterized protein 199862 34687625 LALA0_S10e02124g Lachancea lanzarotensis uncharacterized protein XP_022630304.1 198243 R 1245769 CDS LALA0_S10e02146g 34687626 200319..202457 Unknown 1 NW_019212888.1 highly similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; mRNA-binding ribosome synthesis protein NOC2 202457 34687626 LALA0_S10e02146g Lachancea lanzarotensis mRNA-binding ribosome synthesis protein NOC2 XP_022630305.1 200319 D 1245769 CDS LALA0_S10e02168g 34687627 202768..203394 Unknown 1 NW_019212888.1 similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p; uncharacterized protein 203394 34687627 LALA0_S10e02168g Lachancea lanzarotensis uncharacterized protein XP_022630306.1 202768 D 1245769 CDS LALA0_S10e02190g 34687628 complement(203522..206956) Unknown 1 NW_019212888.1 highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; DNA-directed RNA polymerase III core subunit RET1 206956 34687628 LALA0_S10e02190g Lachancea lanzarotensis DNA-directed RNA polymerase III core subunit RET1 XP_022630307.1 203522 R 1245769 CDS LALA0_S10e02212g 34687629 208648..210177 Unknown 1 NW_019212888.1 highly similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C TFB2 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH; TFIIH/NER complex subunit TFB2 210177 34687629 LALA0_S10e02212g Lachancea lanzarotensis TFIIH/NER complex subunit TFB2 XP_022630308.1 208648 D 1245769 CDS LALA0_S10e02256g 34687631 complement(211311..213185) Unknown 1 NW_019212888.1 similar to uniprot|P24784 Saccharomyces cerevisiae YPL119C (ohnolog of YOR204W) DBP1 Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; DEAD-box ATP-dependent RNA helicase DED1 213185 34687631 LALA0_S10e02256g Lachancea lanzarotensis DEAD-box ATP-dependent RNA helicase DED1 XP_022630309.1 211311 R 1245769 CDS LALA0_S10e02278g 34687632 214440..215498 Unknown 1 NW_019212888.1 similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; mitochondrial 37S ribosomal protein bS1m 215498 34687632 LALA0_S10e02278g Lachancea lanzarotensis mitochondrial 37S ribosomal protein bS1m XP_022630310.1 214440 D 1245769 CDS LALA0_S10e02300g 34687633 complement(215645..216331) Unknown 1 NW_019212888.1 highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphatedehydratase, catalyzes the sixth step in histidinebiosynthesis; mutations cause histidine auxotrophy andsensitivity to Cu, Co, and Ni salts; transcription isregulated by general amino acid control via Gcn4p; imidazoleglycerol-phosphate dehydratase HIS3 216331 34687633 LALA0_S10e02300g Lachancea lanzarotensis imidazoleglycerol-phosphate dehydratase HIS3 XP_022630311.1 215645 R 1245769 CDS LALA0_S10e02322g 34687634 216493..217677 Unknown 1 NW_019212888.1 similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; uncharacterized protein 217677 34687634 LALA0_S10e02322g Lachancea lanzarotensis uncharacterized protein XP_022630312.1 216493 D 1245769 CDS LALA0_S10e02344g 34687635 complement(217854..218684) Unknown 1 NW_019212888.1 highly similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl-diphosphate delta-isomerase IDI1 218684 34687635 LALA0_S10e02344g Lachancea lanzarotensis isopentenyl-diphosphate delta-isomerase IDI1 XP_022630313.1 217854 R 1245769 CDS LALA0_S10e02366g 34687636 220135..221535 Unknown 1 NW_019212888.1 similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity; uncharacterized protein 221535 34687636 LALA0_S10e02366g Lachancea lanzarotensis uncharacterized protein XP_022630314.1 220135 D 1245769 CDS LALA0_S10e02388g 34687637 complement(221671..222957) Unknown 1 NW_019212888.1 similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression; Ca(2+)-dependent cysteine protease MCA1 222957 34687637 LALA0_S10e02388g Lachancea lanzarotensis Ca(2+)-dependent cysteine protease MCA1 XP_022630315.1 221671 R 1245769 CDS LALA0_S10e02410g 34687638 224202..226376 Unknown 1 NW_019212888.1 similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats; histone deacetylase 226376 34687638 LALA0_S10e02410g Lachancea lanzarotensis histone deacetylase XP_022630316.1 224202 D 1245769 CDS LALA0_S10e02432g 34687639 227914..228141 Unknown 1 NW_019212888.1 highly similar to uniprot|C5E2X3 Lachancea thermotolerans KLTH0H08492g hypothetical protein; uncharacterized protein 228141 34687639 LALA0_S10e02432g Lachancea lanzarotensis uncharacterized protein XP_022630317.1 227914 D 1245769 CDS LALA0_S10e02454g 34687640 complement(229414..231048) Unknown 1 NW_019212888.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; uncharacterized protein 231048 34687640 LALA0_S10e02454g Lachancea lanzarotensis uncharacterized protein XP_022630318.1 229414 R 1245769 CDS LALA0_S10e02476g 34687641 232676..233788 Unknown 1 NW_019212888.1 similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C LIP5 Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase; uncharacterized protein 233788 34687641 LALA0_S10e02476g Lachancea lanzarotensis uncharacterized protein XP_022630319.1 232676 D 1245769 CDS LALA0_S10e02498g 34687642 complement(233908..236991) Unknown 1 NW_019212888.1 similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly; GTPase-activating protein BEM3 236991 34687642 LALA0_S10e02498g Lachancea lanzarotensis GTPase-activating protein BEM3 XP_022630320.1 233908 R 1245769 CDS LALA0_S10e02520g 34687643 complement(237331..239499) Unknown 1 NW_019212888.1 weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate; uncharacterized protein 239499 34687643 LALA0_S10e02520g Lachancea lanzarotensis uncharacterized protein XP_022630321.1 237331 R 1245769 CDS LALA0_S10e02542g 34687644 240475..241221 Unknown 1 NW_019212888.1 similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA; transcription initiation factor IIA large subunit 241221 34687644 LALA0_S10e02542g Lachancea lanzarotensis transcription initiation factor IIA large subunit XP_022630322.1 240475 D 1245769 CDS LALA0_S10e02564g 34687645 complement(241530..242675) Unknown 1 NW_019212888.1 similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; glyoxylate reductase 242675 34687645 LALA0_S10e02564g Lachancea lanzarotensis glyoxylate reductase XP_022630323.1 241530 R 1245769 CDS LALA0_S10e02586g 34687646 complement(242879..244147) Unknown 1 NW_019212888.1 similar to uniprot|Q08580 Saccharomyces cerevisiae YOR193W (ohnolog of YPL112C) PEX27 Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p; uncharacterized protein 244147 34687646 LALA0_S10e02586g Lachancea lanzarotensis uncharacterized protein XP_022630324.1 242879 R 1245769 CDS LALA0_S10e02630g 34687648 245696..247264 Unknown 1 NW_019212888.1 highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth; acetyl-CoA hydrolase 247264 34687648 LALA0_S10e02630g Lachancea lanzarotensis acetyl-CoA hydrolase XP_022630325.1 245696 D 1245769 CDS LALA0_S10e02674g 34687650 247783..248316 Unknown 1 NW_019212888.1 highly similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene; Mg-dependent acid phosphatase 248316 34687650 LALA0_S10e02674g Lachancea lanzarotensis Mg-dependent acid phosphatase XP_022630326.1 247783 D 1245769 CDS LALA0_S10e02784g 34687655 complement(250206..252131) Unknown 1 NW_019212888.1 highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; Hsp70 family chaperone SSA2 252131 34687655 LALA0_S10e02784g Lachancea lanzarotensis Hsp70 family chaperone SSA2 XP_022630327.1 250206 R 1245769 CDS LALA0_S10e02806g 34687656 complement(252957..253760) Unknown 1 NW_019212888.1 similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C POM33 Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; nucleoporin POM33 253760 34687656 LALA0_S10e02806g Lachancea lanzarotensis nucleoporin POM33 XP_022630328.1 252957 R 1245769 CDS LALA0_S10e02828g 34687657 complement(253958..255034) Unknown 1 NW_019212888.1 similar to uniprot|C5E2Y7 Lachancea thermotolerans KLTH0H08888g hypothetical protein; uncharacterized protein 255034 34687657 LALA0_S10e02828g Lachancea lanzarotensis uncharacterized protein XP_022630329.1 253958 R 1245769 CDS LALA0_S10e02850g 34687658 255303..256883 Unknown 1 NW_019212888.1 similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; septin CDC3 256883 34687658 LALA0_S10e02850g Lachancea lanzarotensis septin CDC3 XP_022630330.1 255303 D 1245769 CDS LALA0_S10e02872g 34687659 257188..260856 Unknown 1 NW_019212888.1 weakly similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; uncharacterized protein 260856 34687659 LALA0_S10e02872g Lachancea lanzarotensis uncharacterized protein XP_022630331.1 257188 D 1245769 CDS LALA0_S10e02938g 34687662 262530..266852 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q06160 Saccharomyces cerevisiae YLR313C (ohnolog of YLL021W) SPH1 Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; uncharacterized protein 266852 34687662 LALA0_S10e02938g Lachancea lanzarotensis uncharacterized protein XP_022630332.1 262530 D 1245769 CDS LALA0_S10e02960g 34687663 complement(267202..267906) Unknown 1 NW_019212888.1 similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL57 267906 34687663 LALA0_S10e02960g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL57 XP_022630333.1 267202 R 1245769 CDS LALA0_S10e02982g 34687664 268309..270027 Unknown 1 NW_019212888.1 highly similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis; RNA-dependent ATPase ROK1 270027 34687664 LALA0_S10e02982g Lachancea lanzarotensis RNA-dependent ATPase ROK1 XP_022630334.1 268309 D 1245769 CDS LALA0_S10e03004g 34687665 complement(270387..270746) Unknown 1 NW_019212888.1 highly similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex; F1F0 ATP synthase subunit g 270746 34687665 LALA0_S10e03004g Lachancea lanzarotensis F1F0 ATP synthase subunit g XP_022630335.1 270387 R 1245769 CDS LALA0_S10e03026g 34687666 complement(271538..274276) Unknown 1 NW_019212888.1 highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W MCM4 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p; MCM DNA helicase complex subunit MCM4 274276 34687666 LALA0_S10e03026g Lachancea lanzarotensis MCM DNA helicase complex subunit MCM4 XP_022630336.1 271538 R 1245769 CDS LALA0_S10e03048g 34687667 complement(274493..276196) Unknown 1 NW_019212888.1 similar to uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin; uncharacterized protein 276196 34687667 LALA0_S10e03048g Lachancea lanzarotensis uncharacterized protein XP_022630337.1 274493 R 1245769 CDS LALA0_S10e03070g 34687668 complement(276611..278122) Unknown 1 NW_019212888.1 weakly similar to uniprot|P45819 Saccharomyces cerevisiae YGL170C SPO74 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; uncharacterized protein 278122 34687668 LALA0_S10e03070g Lachancea lanzarotensis uncharacterized protein XP_022630338.1 276611 R 1245769 CDS LALA0_S10e03092g 34687669 278685..279113 Unknown 1 NW_019212888.1 similar to uniprot|P32601 Saccharomyces cerevisiae YPR017C DSS4 Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol; guanine nucleotide exchange factor DSS4 279113 34687669 LALA0_S10e03092g Lachancea lanzarotensis guanine nucleotide exchange factor DSS4 XP_022630339.1 278685 D 1245769 CDS LALA0_S10e03114g 34687670 279525..280262 Unknown 1 NW_019212888.1 highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016C TIF6 Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits; translation initiation factor 6 280262 34687670 LALA0_S10e03114g Lachancea lanzarotensis translation initiation factor 6 XP_022630340.1 279525 D 1245769 CDS LALA0_S10e03136g 34687671 282180..282812 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; uncharacterized protein 282812 34687671 LALA0_S10e03136g Lachancea lanzarotensis uncharacterized protein XP_022630341.1 282180 D 1245769 CDS LALA0_S10e03180g 34687673 284045..285013 Unknown 1 NW_019212888.1 similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 285013 34687673 LALA0_S10e03180g Lachancea lanzarotensis uncharacterized protein XP_022630342.1 284045 D 1245769 CDS LALA0_S10e03202g 34687674 join(285331..285363,285463..285651) Unknown 1 NW_019212888.1 similar to uniprot|A5Z2X5 Saccharomyces cerevisiae YPR010C-A Putative protein of unknown function; conserved among Saccharomyces sensu stricto species; uncharacterized protein 285651 34687674 LALA0_S10e03202g Lachancea lanzarotensis uncharacterized protein XP_022630343.1 285331 D 1245769 CDS LALA0_S10e03224g 34687675 complement(286016..287881) Unknown 1 NW_019212888.1 highly similar to Lachancea thermotolerans KLTH0H09020g hypothetical protein; uncharacterized protein 287881 34687675 LALA0_S10e03224g Lachancea lanzarotensis uncharacterized protein XP_022630344.1 286016 R 1245769 CDS LALA0_S10e03246g 34687676 complement(288557..289414) Unknown 1 NW_019212888.1 similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 289414 34687676 LALA0_S10e03246g Lachancea lanzarotensis uncharacterized protein XP_022630345.1 288557 R 1245769 CDS LALA0_S10e03268g 34687677 289885..290241 Unknown 1 NW_019212888.1 highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; H(+)-transporting V1 sector ATPase subunit F 290241 34687677 LALA0_S10e03268g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit F XP_022630346.1 289885 D 1245769 CDS LALA0_S10e03290g 34687678 complement(290466..292466) Unknown 1 NW_019212888.1 similar to uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; uncharacterized protein 292466 34687678 LALA0_S10e03290g Lachancea lanzarotensis uncharacterized protein XP_022630347.1 290466 R 1245769 CDS LALA0_S10e03312g 34687679 complement(292847..294262) Unknown 1 NW_019212888.1 highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; 4-aminobutyrate transaminase 294262 34687679 LALA0_S10e03312g Lachancea lanzarotensis 4-aminobutyrate transaminase XP_022630348.1 292847 R 1245769 CDS LALA0_S10e03334g 34687680 complement(294707..295651) Unknown 1 NW_019212888.1 similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm; uncharacterized protein 295651 34687680 LALA0_S10e03334g Lachancea lanzarotensis uncharacterized protein XP_022630349.1 294707 R 1245769 CDS LALA0_S10e03356g 34687681 complement(295889..296539) Unknown 1 NW_019212888.1 similar to uniprot|C5E300 Lachancea thermotolerans KLTH0H09174g hypothetical protein; uncharacterized protein 296539 34687681 LALA0_S10e03356g Lachancea lanzarotensis uncharacterized protein XP_022630350.1 295889 R 1245769 CDS LALA0_S10e03378g 34687682 296752..297498 Unknown 1 NW_019212888.1 similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases; Ras family GTPase RSR1 297498 34687682 LALA0_S10e03378g Lachancea lanzarotensis Ras family GTPase RSR1 XP_022630351.1 296752 D 1245769 CDS LALA0_S10e03400g 34687683 complement(297608..298990) Unknown 1 NW_019212888.1 similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; initiation-specific alpha-1,6-mannosyltransferase 298990 34687683 LALA0_S10e03400g Lachancea lanzarotensis initiation-specific alpha-1,6-mannosyltransferase XP_022630352.1 297608 R 1245769 CDS LALA0_S10e03422g 34687684 complement(299473..300114) Unknown 1 NW_019212888.1 similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; nicotinamidase 300114 34687684 LALA0_S10e03422g Lachancea lanzarotensis nicotinamidase XP_022630353.1 299473 R 1245769 CDS LALA0_S10e03444g 34687685 301416..303821 Unknown 1 NW_019212888.1 weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene; uncharacterized protein 303821 34687685 LALA0_S10e03444g Lachancea lanzarotensis uncharacterized protein XP_022630354.1 301416 D 1245769 CDS LALA0_S10e03466g 34687686 304036..306147 Unknown 1 NW_019212888.1 highly similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p; ribosome biosynthesis protein ENP2 306147 34687686 LALA0_S10e03466g Lachancea lanzarotensis ribosome biosynthesis protein ENP2 XP_022630355.1 304036 D 1245769 CDS LALA0_S10e03488g 34687687 306387..308186 Unknown 1 NW_019212888.1 similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog; uncharacterized protein 308186 34687687 LALA0_S10e03488g Lachancea lanzarotensis uncharacterized protein XP_022630356.1 306387 D 1245769 CDS LALA0_S10e03510g 34687688 complement(308574..308942) Unknown 1 NW_019212888.1 similar to uniprot|C5E302 Lachancea thermotolerans KLTH0H09218g hypothetical protein; uncharacterized protein 308942 34687688 LALA0_S10e03510g Lachancea lanzarotensis uncharacterized protein XP_022630357.1 308574 R 1245769 CDS LALA0_S10e03532g 34687689 complement(310926..312308) Unknown 1 NW_019212888.1 weakly similar to uniprot|P27705 Saccharomyces cerevisiae YGL035C MIG1 Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; transcription factor MIG1 312308 34687689 LALA0_S10e03532g Lachancea lanzarotensis transcription factor MIG1 XP_022630358.1 310926 R 1245769 CDS LALA0_S10e03554g 34687690 313978..316503 Unknown 1 NW_019212888.1 similar to uniprot|C5E304 Lachancea thermotolerans KLTH0H09262g hypothetical protein; uncharacterized protein 316503 34687690 LALA0_S10e03554g Lachancea lanzarotensis uncharacterized protein XP_022630359.1 313978 D 1245769 CDS LALA0_S10e03576g 34687691 join(316974..317013,317106..317713) Unknown 1 NW_019212888.1 similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; uncharacterized protein 317713 34687691 LALA0_S10e03576g Lachancea lanzarotensis uncharacterized protein XP_022630360.1 316974 D 1245769 CDS LALA0_S10e03598g 34687692 318245..319168 Unknown 1 NW_019212888.1 highly similar to uniprot|C5E304 Lachancea thermotolerans KLTH0H09262g hypothetical protein; uncharacterized protein 319168 34687692 LALA0_S10e03598g Lachancea lanzarotensis uncharacterized protein XP_022630361.1 318245 D 1245769 CDS LALA0_S10e03620g 34687693 complement(319346..320020) Unknown 1 NW_019212888.1 similar to uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 Protein with an apparent role in acetylation of N-terminal methionine residues; uncharacterized protein 320020 34687693 LALA0_S10e03620g Lachancea lanzarotensis uncharacterized protein XP_022630362.1 319346 R 1245769 CDS LALA0_S10e03642g 34687694 complement(320619..320897) Unknown 1 NW_019212888.1 similar to uniprot|P32781 Saccharomyces cerevisiae YGL032C AGA2 Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds; uncharacterized protein 320897 34687694 LALA0_S10e03642g Lachancea lanzarotensis uncharacterized protein XP_022630363.1 320619 R 1245769 CDS LALA0_S10e03664g 34687695 complement(321431..321898) Unknown 1 NW_019212888.1 highly similar to uniprot|P24000 Saccharomyces cerevisiae YGR148C (ohnolog of YGL031C) RPL24B Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate; 60S ribosomal protein eL24 321898 34687695 LALA0_S10e03664g Lachancea lanzarotensis 60S ribosomal protein eL24 XP_022630364.1 321431 R 1245769 CDS LALA0_S10e03686g 34687696 join(322853..322855,322942..323256) Unknown 1 NW_019212888.1 some similarities with uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; 60S ribosomal protein eL30 323256 34687696 LALA0_S10e03686g Lachancea lanzarotensis 60S ribosomal protein eL30 XP_022630365.1 322853 D 1245769 CDS LALA0_S10e03708g 34687697 complement(323433..323714) Unknown 1 NW_019212888.1 similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 323714 34687697 LALA0_S10e03708g Lachancea lanzarotensis uncharacterized protein XP_022630366.1 323433 R 1245769 CDS LALA0_S10e03730g 34687698 complement(323941..325653) Unknown 1 NW_019212888.1 highly similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; aspartate--tRNA ligase DPS1 325653 34687698 LALA0_S10e03730g Lachancea lanzarotensis aspartate--tRNA ligase DPS1 XP_022630367.1 323941 R 1245769 CDS LALA0_S10e03752g 34687699 327379..332184 Unknown 1 NW_019212888.1 some similarities with uniprot|P04821 Saccharomyces cerevisiae YLR310C (ohnolog of YLL016W) CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; Ras family guanine nucleotide exchange factor CDC25 332184 34687699 LALA0_S10e03752g Lachancea lanzarotensis Ras family guanine nucleotide exchange factor CDC25 XP_022630368.1 327379 D 1245769 CDS LALA0_S10e03774g 34687700 332484..335183 Unknown 1 NW_019212888.1 similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; uncharacterized protein 335183 34687700 LALA0_S10e03774g Lachancea lanzarotensis uncharacterized protein XP_022630369.1 332484 D 1245769 CDS LALA0_S10e03796g 34687701 complement(335600..336589) Unknown 1 NW_019212888.1 similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; uncharacterized protein 336589 34687701 LALA0_S10e03796g Lachancea lanzarotensis uncharacterized protein XP_022630370.1 335600 R 1245769 CDS LALA0_S10e03818g 34687702 complement(join(337552..338109,338172..338174)) Unknown 1 NW_019212888.1 similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes; NEDD8-conjugating protein UBC12 338174 34687702 LALA0_S10e03818g Lachancea lanzarotensis NEDD8-conjugating protein UBC12 XP_022630371.1 337552 R 1245769 CDS LALA0_S10e03840g 34687703 339348..340325 Unknown 1 NW_019212888.1 highly similar to uniprot|P05150 Saccharomyces cerevisiae YJL088W ARG3 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine; ornithine carbamoyltransferase 340325 34687703 LALA0_S10e03840g Lachancea lanzarotensis ornithine carbamoyltransferase XP_022630372.1 339348 D 1245769 CDS LALA0_S10e03862g 34687704 complement(340383..342848) Unknown 1 NW_019212888.1 similar to uniprot|P09880 Saccharomyces cerevisiae YJL087C TRL1 tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes; tRNA ligase 342848 34687704 LALA0_S10e03862g Lachancea lanzarotensis tRNA ligase XP_022630373.1 340383 R 1245769 CDS LALA0_S10e03884g 34687705 343152..345017 Unknown 1 NW_019212888.1 similar to uniprot|P19658 Saccharomyces cerevisiae YJL085W EXO70 Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding; GTP-Rho binding exocyst subunit EXO70 345017 34687705 LALA0_S10e03884g Lachancea lanzarotensis GTP-Rho binding exocyst subunit EXO70 XP_022630374.1 343152 D 1245769 CDS LALA0_S10e03906g 34687706 complement(345102..347924) Unknown 1 NW_019212888.1 similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C (ohnolog of YKR021W) ALY2 Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; uncharacterized protein 347924 34687706 LALA0_S10e03906g Lachancea lanzarotensis uncharacterized protein XP_022630375.1 345102 R 1245769 CDS LALA0_S10e03928g 34687707 complement(348362..348766) Unknown 1 NW_019212888.1 similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p; uncharacterized protein 348766 34687707 LALA0_S10e03928g Lachancea lanzarotensis uncharacterized protein XP_022630376.1 348362 R 1245769 CDS LALA0_S10e03950g 34687708 349112..351106 Unknown 1 NW_019212888.1 weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W (ohnolog of YKR019C) TAX4 EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; uncharacterized protein 351106 34687708 LALA0_S10e03950g Lachancea lanzarotensis uncharacterized protein XP_022630377.1 349112 D 1245769 CDS LALA0_S10e03972g 34687709 351412..353589 Unknown 1 NW_019212888.1 similar to uniprot|P47031 Saccharomyces cerevisiae YJL082W (ohnolog of YKR018C) IML2 Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 353589 34687709 LALA0_S10e03972g Lachancea lanzarotensis uncharacterized protein XP_022630378.1 351412 D 1245769 CDS LALA0_S10e03994g 34687710 353784..355415 Unknown 1 NW_019212888.1 similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Putative protein of unknown function; contains a RING finger motif; E3 ubiquitin-protein ligase HEL1 355415 34687710 LALA0_S10e03994g Lachancea lanzarotensis E3 ubiquitin-protein ligase HEL1 XP_022630379.1 353784 D 1245769 CDS LALA0_S10e04016g 34687711 complement(355508..356950) Unknown 1 NW_019212888.1 similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; uncharacterized protein 356950 34687711 LALA0_S10e04016g Lachancea lanzarotensis uncharacterized protein XP_022630380.1 355508 R 1245769 CDS LALA0_S10e04038g 34687712 complement(357253..358851) Unknown 1 NW_019212888.1 similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FCJ1 Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance; uncharacterized protein 358851 34687712 LALA0_S10e04038g Lachancea lanzarotensis uncharacterized protein XP_022630381.1 357253 R 1245769 CDS LALA0_S10e04060g 34687713 359465..359926 Unknown 1 NW_019212888.1 hypothetical protein; uncharacterized protein 359926 34687713 LALA0_S10e04060g Lachancea lanzarotensis uncharacterized protein XP_022630382.1 359465 D 1245769 CDS LALA0_S10e04082g 34687714 360331..361620 Unknown 1 NW_019212888.1 similar to uniprot|C5E339 Lachancea thermotolerans KLTH0H10142g hypothetical protein; uncharacterized protein 361620 34687714 LALA0_S10e04082g Lachancea lanzarotensis uncharacterized protein XP_022630383.1 360331 D 1245769 CDS LALA0_S10e04104g 34687715 362449..363078 Unknown 1 NW_019212888.1 similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; Rab family GTPase YPT52 363078 34687715 LALA0_S10e04104g Lachancea lanzarotensis Rab family GTPase YPT52 XP_022630384.1 362449 D 1245769 CDS LALA0_S10e04126g 34687716 complement(363402..367016) Unknown 1 NW_019212888.1 similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins; uncharacterized protein 367016 34687716 LALA0_S10e04126g Lachancea lanzarotensis uncharacterized protein XP_022630385.1 363402 R 1245769 CDS LALA0_S10e04148g 34687717 complement(367560..368282) Unknown 1 NW_019212888.1 some similarities with uniprot|P47033 Saccharomyces cerevisiae YJL078C PRY3 Cell wall protein with a role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; uncharacterized protein 368282 34687717 LALA0_S10e04148g Lachancea lanzarotensis uncharacterized protein XP_022630386.1 367560 R 1245769 CDS LALA0_S10e04170g 34687718 complement(368601..369665) Unknown 1 NW_019212888.1 similar to uniprot|P47032 Saccharomyces cerevisiae YJL079C (ohnolog of YKR013W) PRY1 Protein of unknown function; uncharacterized protein 369665 34687718 LALA0_S10e04170g Lachancea lanzarotensis uncharacterized protein XP_022630387.1 368601 R 1245769 CDS LALA0_S10e04192g 34687719 complement(371333..372802) Unknown 1 NW_019212888.1 weakly similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane; uncharacterized protein 372802 34687719 LALA0_S10e04192g Lachancea lanzarotensis uncharacterized protein XP_022630388.1 371333 R 1245769 CDS LALA0_S10e04214g 34687720 373542..374180 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q96VH4 Saccharomyces cerevisiae YCL026C-B HBN1 Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; uncharacterized protein 374180 34687720 LALA0_S10e04214g Lachancea lanzarotensis uncharacterized protein XP_022630389.1 373542 D 1245769 CDS LALA0_S10e04236g 34687721 375042..377054 Unknown 1 NW_019212888.1 weakly similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment; uncharacterized protein 377054 34687721 LALA0_S10e04236g Lachancea lanzarotensis uncharacterized protein XP_022630390.1 375042 D 1245769 CDS LALA0_S10e04280g 34687723 378720..379679 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q02209 Saccharomyces cerevisiae YKR011C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; uncharacterized protein 379679 34687723 LALA0_S10e04280g Lachancea lanzarotensis uncharacterized protein XP_022630391.1 378720 D 1245769 CDS LALA0_S10e04302g 34687724 complement(379809..381563) Unknown 1 NW_019212888.1 similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p; deoxyribodipyrimidine photo-lyase PHR1 381563 34687724 LALA0_S10e04302g Lachancea lanzarotensis deoxyribodipyrimidine photo-lyase PHR1 XP_022630392.1 379809 R 1245769 CDS LALA0_S10e04324g 34687725 complement(382093..382968) Unknown 1 NW_019212888.1 similar to uniprot|P38765 Saccharomyces cerevisiae YHR029C YHI9 Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production; uncharacterized protein 382968 34687725 LALA0_S10e04324g Lachancea lanzarotensis uncharacterized protein XP_022630393.1 382093 R 1245769 CDS LALA0_S10e04346g 34687726 384210..387968 Unknown 1 NW_019212888.1 weakly similar to uniprot|P47035 Saccharomyces cerevisiae YJL076W (ohnolog of YKR010C) NET1 Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; uncharacterized protein 387968 34687726 LALA0_S10e04346g Lachancea lanzarotensis uncharacterized protein XP_022630394.1 384210 D 1245769 CDS LALA0_S10e04368g 34687727 complement(388070..391711) Unknown 1 NW_019212888.1 similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member; cohesin subunit SMC3 391711 34687727 LALA0_S10e04368g Lachancea lanzarotensis cohesin subunit SMC3 XP_022630395.1 388070 R 1245769 CDS LALA0_S10e04412g 34687729 complement(393215..394459) Unknown 1 NW_019212888.1 similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene; uncharacterized protein 394459 34687729 LALA0_S10e04412g Lachancea lanzarotensis uncharacterized protein XP_022630396.1 393215 R 1245769 CDS LALA0_S10e04434g 34687730 395213..397087 Unknown 1 NW_019212888.1 similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2; uncharacterized protein 397087 34687730 LALA0_S10e04434g Lachancea lanzarotensis uncharacterized protein XP_022630397.1 395213 D 1245769 CDS LALA0_S10e04456g 34687731 complement(397192..398736) Unknown 1 NW_019212888.1 similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y, processed to mature form by Prb1p; aminopeptidase Y 398736 34687731 LALA0_S10e04456g Lachancea lanzarotensis aminopeptidase Y XP_022630398.1 397192 R 1245769 CDS LALA0_S10e04500g 34687733 complement(399543..400052) Unknown 1 NW_019212888.1 similar to uniprot|C5DNA2 Lachancea thermotolerans KLTH0G15334g hypothetical protein; uncharacterized protein 400052 34687733 LALA0_S10e04500g Lachancea lanzarotensis uncharacterized protein XP_022630399.1 399543 R 1245769 CDS LALA0_S10e04522g 34687734 complement(400582..401205) Unknown 1 NW_019212888.1 similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; DNA replication protein PSF2 401205 34687734 LALA0_S10e04522g Lachancea lanzarotensis DNA replication protein PSF2 XP_022630400.1 400582 R 1245769 CDS LALA0_S10e04544g 34687735 401416..403071 Unknown 1 NW_019212888.1 similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p; acetyl-CoA:L-glutamate N-acetyltransferase 403071 34687735 LALA0_S10e04544g Lachancea lanzarotensis acetyl-CoA:L-glutamate N-acetyltransferase XP_022630401.1 401416 D 1245769 CDS LALA0_S10e04566g 34687736 complement(403382..405733) Unknown 1 NW_019212888.1 similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C (ohnolog of YBR284W) Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene; metallo-dependent hydrolase superfamily protein 405733 34687736 LALA0_S10e04566g Lachancea lanzarotensis metallo-dependent hydrolase superfamily protein XP_022630402.1 403382 R 1245769 CDS LALA0_S10e04610g 34687738 407377..408858 Unknown 1 NW_019212888.1 highly similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine; glycine hydroxymethyltransferase SHM1 408858 34687738 LALA0_S10e04610g Lachancea lanzarotensis glycine hydroxymethyltransferase SHM1 XP_022630403.1 407377 D 1245769 CDS LALA0_S10e04632g 34687739 complement(408932..409537) Unknown 1 NW_019212888.1 similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C (ohnolog of YNL093W) VPS21 Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; Rab family GTPase YPT10 409537 34687739 LALA0_S10e04632g Lachancea lanzarotensis Rab family GTPase YPT10 XP_022630404.1 408932 R 1245769 CDS LALA0_S10e04654g 34687740 410750..415396 Unknown 1 NW_019212888.1 weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; DNA-binding protein RIF1 415396 34687740 LALA0_S10e04654g Lachancea lanzarotensis DNA-binding protein RIF1 XP_022630405.1 410750 D 1245769 CDS LALA0_S10e04676g 34687741 complement(join(415475..416918,416995..417083)) Unknown 1 NW_019212888.1 similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase; serine/threonine protein kinase CHK1 417083 34687741 LALA0_S10e04676g Lachancea lanzarotensis serine/threonine protein kinase CHK1 XP_022630406.1 415475 R 1245769 CDS LALA0_S10e04698g 34687742 417945..419231 Unknown 1 NW_019212888.1 similar to uniprot|P47049 Saccharomyces cerevisiae YJL048C (ohnolog of YBR273C) UBX6 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; uncharacterized protein 419231 34687742 LALA0_S10e04698g Lachancea lanzarotensis uncharacterized protein XP_022630407.1 417945 D 1245769 CDS LALA0_S10e04720g 34687743 complement(419245..420618) Unknown 1 NW_019212888.1 weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Putative protein of unknown function; YJL049W is a non-essential gene; uncharacterized protein 420618 34687743 LALA0_S10e04720g Lachancea lanzarotensis uncharacterized protein XP_022630408.1 419245 R 1245769 CDS LALA0_S10e04742g 34687744 420782..422233 Unknown 1 NW_019212888.1 similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C HSM3 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; uncharacterized protein 422233 34687744 LALA0_S10e04742g Lachancea lanzarotensis uncharacterized protein XP_022630409.1 420782 D 1245769 CDS LALA0_S10e04764g 34687745 complement(422272..425529) Unknown 1 NW_019212888.1 highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity; ATP-dependent RNA helicase MTR4 425529 34687745 LALA0_S10e04764g Lachancea lanzarotensis ATP-dependent RNA helicase MTR4 XP_022630410.1 422272 R 1245769 CDS LALA0_S10e04786g 34687746 427735..429690 Unknown 1 NW_019212888.1 similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; chitinase 429690 34687746 LALA0_S10e04786g Lachancea lanzarotensis chitinase XP_022630411.1 427735 D 1245769 CDS LALA0_S10e04808g 34687747 complement(429819..430613) Unknown 1 NW_019212888.1 similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination; S-adenosylmethionine-dependent methyltransferase 430613 34687747 LALA0_S10e04808g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022630412.1 429819 R 1245769 CDS LALA0_S10e04830g 34687748 431733..432572 Unknown 1 NW_019212888.1 similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; dodecenoyl-CoA isomerase 432572 34687748 LALA0_S10e04830g Lachancea lanzarotensis dodecenoyl-CoA isomerase XP_022630413.1 431733 D 1245769 CDS LALA0_S10e04852g 34687749 complement(432695..433591) Unknown 1 NW_019212888.1 similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene; uncharacterized protein 433591 34687749 LALA0_S10e04852g Lachancea lanzarotensis uncharacterized protein XP_022630414.1 432695 R 1245769 CDS LALA0_S10e04874g 34687750 complement(434481..435389) Unknown 1 NW_019212888.1 similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response; uncharacterized protein 435389 34687750 LALA0_S10e04874g Lachancea lanzarotensis uncharacterized protein XP_022630415.1 434481 R 1245769 CDS LALA0_S10e04896g 34687751 435536..436027 Unknown 1 NW_019212888.1 similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene; uncharacterized protein 436027 34687751 LALA0_S10e04896g Lachancea lanzarotensis uncharacterized protein XP_022630416.1 435536 D 1245769 CDS LALA0_S10e04918g 34687752 436699..440106 Unknown 1 NW_019212888.1 similar to uniprot|Q05854 Saccharomyces cerevisiae YLR278C Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene; uncharacterized protein 440106 34687752 LALA0_S10e04918g Lachancea lanzarotensis uncharacterized protein XP_022630417.1 436699 D 1245769 CDS LALA0_S10e04940g 34687753 441019..443349 Unknown 1 NW_019212888.1 highly similar to uniprot|Q08553 Saccharomyces cerevisiae YOR179C (ohnolog of YLR277C) SYC1 Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; cleavage polyadenylation factor subunit YSH1 443349 34687753 LALA0_S10e04940g Lachancea lanzarotensis cleavage polyadenylation factor subunit YSH1 XP_022630418.1 441019 D 1245769 CDS LALA0_S10e04962g 34687754 443550..445343 Unknown 1 NW_019212888.1 highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit; ATP-dependent DNA/RNA helicase 445343 34687754 LALA0_S10e04962g Lachancea lanzarotensis ATP-dependent DNA/RNA helicase XP_022630419.1 443550 D 1245769 CDS LALA0_S10e04984g 34687755 complement(join(445504..445825,445909..445913)) Unknown 1 NW_019212888.1 highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2; mRNA splicing protein SMD2 445913 34687755 LALA0_S10e04984g Lachancea lanzarotensis mRNA splicing protein SMD2 XP_022630420.1 445504 R 1245769 CDS LALA0_S10e05006g 34687756 complement(446101..448392) Unknown 1 NW_019212888.1 highly similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W MCM5 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; MCM DNA helicase complex subunit MCM5 448392 34687756 LALA0_S10e05006g Lachancea lanzarotensis MCM DNA helicase complex subunit MCM5 XP_022630421.1 446101 R 1245769 CDS LALA0_S10e05050g 34687758 454162..456267 Unknown 1 NW_019212888.1 weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C (ohnolog of YLR273C) GAC1 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; 456267 34687758 LALA0_S10e05050g Lachancea lanzarotensis 454162 D 1245769 CDS LALA0_S10e05072g 34687759 456811..458514 Unknown 1 NW_019212888.1 similar to uniprot|C5DNB0 Lachancea thermotolerans KLTH0G15532g hypothetical protein; uncharacterized protein 458514 34687759 LALA0_S10e05072g Lachancea lanzarotensis uncharacterized protein XP_022630422.1 456811 D 1245769 CDS LALA0_S10e05116g 34687761 459150..462587 Unknown 1 NW_019212888.1 similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; condensin subunit YCS4 462587 34687761 LALA0_S10e05116g Lachancea lanzarotensis condensin subunit YCS4 XP_022630423.1 459150 D 1245769 CDS LALA0_S10e05138g 34687762 complement(462659..463810) Unknown 1 NW_019212888.1 highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; ferrochelatase HEM15 463810 34687762 LALA0_S10e05138g Lachancea lanzarotensis ferrochelatase HEM15 XP_022630424.1 462659 R 1245769 CDS LALA0_S10e05160g 34687763 465081..466901 Unknown 1 NW_019212888.1 similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C ALE1 Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids; lysophospholipid acyltransferase 466901 34687763 LALA0_S10e05160g Lachancea lanzarotensis lysophospholipid acyltransferase XP_022630425.1 465081 D 1245769 CDS LALA0_S10e05182g 34687764 complement(466961..467761) Unknown 1 NW_019212888.1 similar to uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; uncharacterized protein 467761 34687764 LALA0_S10e05182g Lachancea lanzarotensis uncharacterized protein XP_022630426.1 466961 R 1245769 CDS LALA0_S10e05204g 34687765 complement(468184..468969) Unknown 1 NW_019212888.1 weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; uncharacterized protein 468969 34687765 LALA0_S10e05204g Lachancea lanzarotensis uncharacterized protein XP_022630427.1 468184 R 1245769 CDS LALA0_S10e05226g 34687766 complement(469260..470342) Unknown 1 NW_019212888.1 highly similar to uniprot|Q12123 Saccharomyces cerevisiae YOR173W (ohnolog of YLR270W) DCS2 Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase 470342 34687766 LALA0_S10e05226g Lachancea lanzarotensis 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase XP_022630428.1 469260 R 1245769 CDS LALA0_S10e05248g 34687767 complement(join(471190..471800,471873..471906)) Unknown 1 NW_019212888.1 highly similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog; SNAP receptor SEC22 471906 34687767 LALA0_S10e05248g Lachancea lanzarotensis SNAP receptor SEC22 XP_022630429.1 471190 R 1245769 CDS LALA0_S10e05270g 34687768 473046..473990 Unknown 1 NW_019212888.1 weakly similar to Lachancea thermotolerans KLTH0F00264g hypothetical protein; uncharacterized protein 473990 34687768 LALA0_S10e05270g Lachancea lanzarotensis uncharacterized protein XP_022630430.1 473046 D 1245769 CDS LALA0_S10e05292g 34687769 474303..475325 Unknown 1 NW_019212888.1 weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W SPP381 mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; U4/U6-U5 snRNP complex subunit SPP381 475325 34687769 LALA0_S10e05292g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit SPP381 XP_022630431.1 474303 D 1245769 CDS LALA0_S10e05314g 34687770 475486..476238 Unknown 1 NW_019212888.1 similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase 476238 34687770 LALA0_S10e05314g Lachancea lanzarotensis 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase XP_022630432.1 475486 D 1245769 CDS LALA0_S10e05336g 34687771 complement(476376..477023) Unknown 1 NW_019212888.1 highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; DNA-directed RNA polymerase core subunit RPB5 477023 34687771 LALA0_S10e05336g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPB5 XP_022630433.1 476376 R 1245769 CDS LALA0_S10e05358g 34687772 complement(477377..480175) Unknown 1 NW_019212888.1 similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid; uncharacterized protein 480175 34687772 LALA0_S10e05358g Lachancea lanzarotensis uncharacterized protein XP_022630434.1 477377 R 1245769 CDS LALA0_S10e05380g 34687773 480511..480861 Unknown 1 NW_019212888.1 similar to uniprot|Q3E835 Saccharomyces cerevisiae YOL086W-A Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability; uncharacterized protein 480861 34687773 LALA0_S10e05380g Lachancea lanzarotensis uncharacterized protein XP_022630435.1 480511 D 1245769 CDS LALA0_S10e05402g 34687774 complement(481066..481905) Unknown 1 NW_019212888.1 highly similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS9m 481905 34687774 LALA0_S10e05402g Lachancea lanzarotensis mitochondrial 37S ribosomal protein uS9m XP_022630436.1 481066 R 1245769 CDS LALA0_S10e05424g 34687775 complement(482515..483570) Unknown 1 NW_019212888.1 highly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcohol dehydrogenase isoenzyme V; involved in ethanol production; alcohol dehydrogenase ADH5 483570 34687775 LALA0_S10e05424g Lachancea lanzarotensis alcohol dehydrogenase ADH5 XP_022630437.1 482515 R 1245769 CDS LALA0_S10e05446g 34687776 485621..486619 Unknown 1 NW_019212888.1 highly similar to uniprot|P00359 Saccharomyces cerevisiae YGR192C (ohnolog of YJR009C) TDH3 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; uncharacterized protein 486619 34687776 LALA0_S10e05446g Lachancea lanzarotensis uncharacterized protein XP_022630438.1 485621 D 1245769 CDS LALA0_S10e05468g 34687777 488060..490960 Unknown 1 NW_019212888.1 similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; uncharacterized protein 490960 34687777 LALA0_S10e05468g Lachancea lanzarotensis uncharacterized protein XP_022630439.1 488060 D 1245769 CDS LALA0_S10e05490g 34687778 complement(491840..493702) Unknown 1 NW_019212888.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; uncharacterized protein 493702 34687778 LALA0_S10e05490g Lachancea lanzarotensis uncharacterized protein XP_022630440.1 491840 R 1245769 CDS LALA0_S10e05512g 34687779 495866..497425 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q12292 Saccharomyces cerevisiae YOL083W ATG34 Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog; uncharacterized protein 497425 34687779 LALA0_S10e05512g Lachancea lanzarotensis uncharacterized protein XP_022630441.1 495866 D 1245769 CDS LALA0_S10e05534g 34687780 497969..499282 Unknown 1 NW_019212888.1 highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; translation termination factor eRF1 499282 34687780 LALA0_S10e05534g Lachancea lanzarotensis translation termination factor eRF1 XP_022630442.1 497969 D 1245769 CDS LALA0_S10e05556g 34687781 complement(499472..501901) Unknown 1 NW_019212888.1 similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; uncharacterized protein 501901 34687781 LALA0_S10e05556g Lachancea lanzarotensis uncharacterized protein XP_022630443.1 499472 R 1245769 CDS LALA0_S10e05578g 34687782 502118..503119 Unknown 1 NW_019212888.1 similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene; 25S rRNA (adenine2142-N1)-methyltransferase 503119 34687782 LALA0_S10e05578g Lachancea lanzarotensis 25S rRNA (adenine2142-N1)-methyltransferase XP_022630444.1 502118 D 1245769 CDS LALA0_S10e05600g 34687783 503950..512586 Unknown 1 NW_019212888.1 similar to uniprot|P18963 Saccharomyces cerevisiae YBR140C (ohnolog of YOL081W) IRA1 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; uncharacterized protein 512586 34687783 LALA0_S10e05600g Lachancea lanzarotensis uncharacterized protein XP_022630445.1 503950 D 1245769 CDS LALA0_S10e05622g 34687784 complement(512692..513612) Unknown 1 NW_019212888.1 similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly; uncharacterized protein 513612 34687784 LALA0_S10e05622g Lachancea lanzarotensis uncharacterized protein XP_022630446.1 512692 R 1245769 CDS LALA0_S10e05644g 34687785 514523..517753 Unknown 1 NW_019212888.1 similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; uncharacterized protein 517753 34687785 LALA0_S10e05644g Lachancea lanzarotensis uncharacterized protein XP_022630447.1 514523 D 1245769 CDS LALA0_S10e05666g 34687786 complement(517774..519246) Unknown 1 NW_019212888.1 similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; carboxypeptidase C 519246 34687786 LALA0_S10e05666g Lachancea lanzarotensis carboxypeptidase C XP_022630448.1 517774 R 1245769 CDS LALA0_S10e05688g 34687787 520079..520288 Unknown 1 NW_019212888.1 similar to uniprot|P81451 Saccharomyces cerevisiae YOL077W-A ATP19 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase; F1F0 ATP synthase subunit k 520288 34687787 LALA0_S10e05688g Lachancea lanzarotensis F1F0 ATP synthase subunit k XP_022630449.1 520079 D 1245769 CDS LALA0_S10e05710g 34687788 complement(520511..521398) Unknown 1 NW_019212888.1 highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif; ribosome biogenesis protein BRX1 521398 34687788 LALA0_S10e05710g Lachancea lanzarotensis ribosome biogenesis protein BRX1 XP_022630450.1 520511 R 1245769 CDS LALA0_S10e05732g 34687789 521723..524065 Unknown 1 NW_019212888.1 similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; uncharacterized protein 524065 34687789 LALA0_S10e05732g Lachancea lanzarotensis uncharacterized protein XP_022630451.1 521723 D 1245769 CDS LALA0_S10e05754g 34687790 524440..526326 Unknown 1 NW_019212888.1 similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; alpha-1,2-mannosyltransferase MNN2 526326 34687790 LALA0_S10e05754g Lachancea lanzarotensis alpha-1,2-mannosyltransferase MNN2 XP_022630452.1 524440 D 1245769 CDS LALA0_S10e05776g 34687791 527040..527723 Unknown 1 NW_019212888.1 similar to uniprot|Q12438 Saccharomyces cerevisiae YDL010W (ohnolog of YBR014C) GRX6 Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7; uncharacterized protein 527723 34687791 LALA0_S10e05776g Lachancea lanzarotensis uncharacterized protein XP_022630453.1 527040 D 1245769 CDS LALA0_S10e05798g 34687792 528131..528541 Unknown 1 NW_019212888.1 similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity; anaphase promoting complex subunit 11 528541 34687792 LALA0_S10e05798g Lachancea lanzarotensis anaphase promoting complex subunit 11 XP_022630454.1 528131 D 1245769 CDS LALA0_S10e05820g 34687793 join(529340..529364,529429..529991) Unknown 1 NW_019212888.1 weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W (ohnolog of YBR005W) RCR2 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p; uncharacterized protein 529991 34687793 LALA0_S10e05820g Lachancea lanzarotensis uncharacterized protein XP_022630455.1 529340 D 1245769 CDS LALA0_S10e05842g 34687794 530392..531876 Unknown 1 NW_019212888.1 highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; succinate-semialdehyde dehydrogenase (NAD(P)(+)) 531876 34687794 LALA0_S10e05842g Lachancea lanzarotensis succinate-semialdehyde dehydrogenase (NAD(P)(+)) XP_022630456.1 530392 D 1245769 CDS LALA0_S10e05864g 34687795 532100..533539 Unknown 1 NW_019212888.1 similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p; uncharacterized protein 533539 34687795 LALA0_S10e05864g Lachancea lanzarotensis uncharacterized protein XP_022630457.1 532100 D 1245769 CDS LALA0_S10e05886g 34687796 complement(join(533779..534915,535048..535053)) Unknown 1 NW_019212888.1 similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB; RNA polymerase III-inhibiting protein MAF1 535053 34687796 LALA0_S10e05886g Lachancea lanzarotensis RNA polymerase III-inhibiting protein MAF1 XP_022630458.1 533779 R 1245769 CDS LALA0_S10e05908g 34687797 complement(535563..537458) Unknown 1 NW_019212888.1 weakly similar to uniprot|P38213 Saccharomyces cerevisiae YBR007C DSF2 Deletion suppressor of mpt5 mutation; uncharacterized protein 537458 34687797 LALA0_S10e05908g Lachancea lanzarotensis uncharacterized protein XP_022630459.1 535563 R 1245769 CDS LALA0_S10e05930g 34687798 complement(537868..540573) Unknown 1 NW_019212888.1 similar to uniprot|P40317 Saccharomyces cerevisiae YDR006C SOK1 Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13; uncharacterized protein 540573 34687798 LALA0_S10e05930g Lachancea lanzarotensis uncharacterized protein XP_022630460.1 537868 R 1245769 CDS LALA0_S10e05952g 34687799 544985..546913 Unknown 1 NW_019212888.1 similar to uniprot|P33329 Saccharomyces cerevisiae YDR436W (ohnolog of YML016C) PPZ2 Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; salt homeostasis regulator 546913 34687799 LALA0_S10e05952g Lachancea lanzarotensis salt homeostasis regulator XP_022630461.1 544985 D 1245769 CDS LALA0_S10e05974g 34687800 547105..547548 Unknown 1 NW_019212888.1 similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W GPI19 Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P; phosphatidylinositol N-acetylglucosaminyltransferase GPI19 547548 34687800 LALA0_S10e05974g Lachancea lanzarotensis phosphatidylinositol N-acetylglucosaminyltransferase GPI19 XP_022630462.1 547105 D 1245769 CDS LALA0_S10e05996g 34687801 complement(547653..549041) Unknown 1 NW_019212888.1 weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing; uncharacterized protein 549041 34687801 LALA0_S10e05996g Lachancea lanzarotensis uncharacterized protein XP_022630463.1 547653 R 1245769 CDS LALA0_S10e06018g 34687802 550727..551929 Unknown 1 NW_019212888.1 similar to uniprot|Q04083 Saccharomyces cerevisiae YDR438W (ohnolog of YML018C) THI74 Mitochondrial transporter repressible by thiamine; uncharacterized protein 551929 34687802 LALA0_S10e06018g Lachancea lanzarotensis uncharacterized protein XP_022630464.1 550727 D 1245769 CDS LALA0_S10e06040g 34687803 complement(552048..553019) Unknown 1 NW_019212888.1 similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W OST6 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; dolichyl-diphosphooligosaccharide--protein glycotransferase 553019 34687803 LALA0_S10e06040g Lachancea lanzarotensis dolichyl-diphosphooligosaccharide--protein glycotransferase XP_022630465.1 552048 R 1245769 CDS LALA0_S10e06062g 34687804 553896..554648 Unknown 1 NW_019212888.1 weakly similar to uniprot|Q04087 Saccharomyces cerevisiae YDR439W LRS4 Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation; uncharacterized protein 554648 34687804 LALA0_S10e06062g Lachancea lanzarotensis uncharacterized protein XP_022630466.1 553896 D 1245769 CDS LALA0_S10e06084g 34687805 complement(554712..556706) Unknown 1 NW_019212888.1 similar to uniprot|Q03722 Saccharomyces cerevisiae YML020W Putative protein of unknown function; uncharacterized protein 556706 34687805 LALA0_S10e06084g Lachancea lanzarotensis uncharacterized protein XP_022630467.1 554712 R 1245769 CDS LALA0_S10e06106g 34687806 557091..558095 Unknown 1 NW_019212888.1 similar to uniprot|P12887 Saccharomyces cerevisiae YML021C UNG1 Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus; uracil-DNA glycosylase 558095 34687806 LALA0_S10e06106g Lachancea lanzarotensis uracil-DNA glycosylase XP_022630468.1 557091 D 1245769 CDS LALA0_S11e00100g 34687807 2..97 Unknown 1 NW_019212889.1 hypothetical protein; 97 34687807 LALA0_S11e00100g Lachancea lanzarotensis 2 D 1245769 CDS LALA0_S11e00122g 34687808 1494..2834 Unknown 1 NW_019212889.1 weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; uncharacterized protein 2834 34687808 LALA0_S11e00122g Lachancea lanzarotensis uncharacterized protein XP_022630469.1 1494 D 1245769 CDS LALA0_S11e00144g 34687809 complement(2864..5935) Unknown 1 NW_019212889.1 weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres; chromatin-modulating protein MRC1 5935 34687809 LALA0_S11e00144g Lachancea lanzarotensis chromatin-modulating protein MRC1 XP_022630470.1 2864 R 1245769 CDS LALA0_S11e00166g 34687810 complement(6195..7202) Unknown 1 NW_019212889.1 highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; ribosome biosynthesis protein KRR1 7202 34687810 LALA0_S11e00166g Lachancea lanzarotensis ribosome biosynthesis protein KRR1 XP_022630471.1 6195 R 1245769 CDS LALA0_S11e00188g 34687811 7654..7974 Unknown 1 NW_019212889.1 similar to uniprot|Q2V2Q1 Saccharomyces cerevisiae YCL058W-A ADF1 Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand; uncharacterized protein 7974 34687811 LALA0_S11e00188g Lachancea lanzarotensis uncharacterized protein XP_022630472.1 7654 D 1245769 CDS LALA0_S11e00210g 34687812 complement(8340..8588) Unknown 1 NW_019212889.1 similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 8588 34687812 LALA0_S11e00210g Lachancea lanzarotensis uncharacterized protein XP_022630473.1 8340 R 1245769 CDS LALA0_S11e00232g 34687813 complement(9193..9783) Unknown 1 NW_019212889.1 similar to uniprot|C5DJZ6 Lachancea thermotolerans KLTH0F00594g hypothetical protein; uncharacterized protein 9783 34687813 LALA0_S11e00232g Lachancea lanzarotensis uncharacterized protein XP_022630474.1 9193 R 1245769 CDS LALA0_S11e00254g 34687814 complement(9917..11113) Unknown 1 NW_019212889.1 similar to uniprot|C5DJZ7 Lachancea thermotolerans KLTH0F00616g hypothetical protein; uncharacterized protein 11113 34687814 LALA0_S11e00254g Lachancea lanzarotensis uncharacterized protein XP_022630475.1 9917 R 1245769 CDS LALA0_S11e00276g 34687815 12804..13943 Unknown 1 NW_019212889.1 similar to Lachancea thermotolerans KLTH0F00682g hypothetical protein; uncharacterized protein 13943 34687815 LALA0_S11e00276g Lachancea lanzarotensis uncharacterized protein XP_022630476.1 12804 D 1245769 CDS LALA0_S11e00298g 34687816 15062..16027 Unknown 1 NW_019212889.1 similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KAR4 Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone; uncharacterized protein 16027 34687816 LALA0_S11e00298g Lachancea lanzarotensis uncharacterized protein XP_022630477.1 15062 D 1245769 CDS LALA0_S11e00320g 34687817 complement(16158..17675) Unknown 1 NW_019212889.1 highly similar to Lachancea thermotolerans KLTH0F00748g hypothetical protein; uncharacterized protein 17675 34687817 LALA0_S11e00320g Lachancea lanzarotensis uncharacterized protein XP_022630478.1 16158 R 1245769 CDS LALA0_S11e00342g 34687818 18512..20983 Unknown 1 NW_019212889.1 highly similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants; 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase 20983 34687818 LALA0_S11e00342g Lachancea lanzarotensis 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase XP_022630479.1 18512 D 1245769 CDS LALA0_S11e00364g 34687819 complement(21039..22286) Unknown 1 NW_019212889.1 similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X; uncharacterized protein 22286 34687819 LALA0_S11e00364g Lachancea lanzarotensis uncharacterized protein XP_022630480.1 21039 R 1245769 CDS LALA0_S11e00386g 34687820 23619..24839 Unknown 1 NW_019212889.1 similar to Lachancea thermotolerans KLTH0F00748g hypothetical protein; uncharacterized protein 24839 34687820 LALA0_S11e00386g Lachancea lanzarotensis uncharacterized protein XP_022630481.1 23619 D 1245769 CDS LALA0_S11e00408g 34687821 complement(25154..25540) Unknown 1 NW_019212889.1 highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C QCR7 Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; ubiquinol--cytochrome-c reductase subunit 7 25540 34687821 LALA0_S11e00408g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit 7 XP_022630482.1 25154 R 1245769 CDS LALA0_S11e00430g 34687822 complement(25749..26705) Unknown 1 NW_019212889.1 similar to uniprot|P22108 Saccharomyces cerevisiae YDR530C (ohnolog of YCL050C) APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p; uncharacterized protein 26705 34687822 LALA0_S11e00430g Lachancea lanzarotensis uncharacterized protein XP_022630483.1 25749 R 1245769 CDS LALA0_S11e00452g 34687823 28082..29185 Unknown 1 NW_019212889.1 similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W CAB1 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element; pantothenate kinase 29185 34687823 LALA0_S11e00452g Lachancea lanzarotensis pantothenate kinase XP_022630484.1 28082 D 1245769 CDS LALA0_S11e00474g 34687824 complement(29260..30345) Unknown 1 NW_019212889.1 weakly similar to uniprot|Q6Q537 Saccharomyces cerevisiae YDR532C KRE28 Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components; uncharacterized protein 30345 34687824 LALA0_S11e00474g Lachancea lanzarotensis uncharacterized protein XP_022630485.1 29260 R 1245769 CDS LALA0_S11e00496g 34687825 complement(31296..32645) Unknown 1 NW_019212889.1 similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W RBA50 Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; uncharacterized protein 32645 34687825 LALA0_S11e00496g Lachancea lanzarotensis uncharacterized protein XP_022630486.1 31296 R 1245769 CDS LALA0_S11e00518g 34687826 complement(33657..33887) Unknown 1 NW_019212889.1 similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A SNA2 Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 33887 34687826 LALA0_S11e00518g Lachancea lanzarotensis uncharacterized protein XP_022630487.1 33657 R 1245769 CDS LALA0_S11e00540g 34687827 complement(34051..34854) Unknown 1 NW_019212889.1 similar to uniprot|P32460 Saccharomyces cerevisiae YIR030C DCG1 Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain; uncharacterized protein 34854 34687827 LALA0_S11e00540g Lachancea lanzarotensis uncharacterized protein XP_022630488.1 34051 R 1245769 CDS LALA0_S11e00584g 34687829 36266..36463 Unknown 1 NW_019212889.1 highly similar to uniprot|Q3E6R4 Saccharomyces cerevisiae YDR524C-B (ohnolog of YCL048W-A) Putative protein of unknown function; uncharacterized protein 36463 34687829 LALA0_S11e00584g Lachancea lanzarotensis uncharacterized protein XP_022630489.1 36266 D 1245769 CDS LALA0_S11e00606g 34687830 37323..39866 Unknown 1 NW_019212889.1 some similarities with uniprot|Q04412 Saccharomyces cerevisiae YDR524C AGE1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif; GTPase-activating protein AGE1 39866 34687830 LALA0_S11e00606g Lachancea lanzarotensis GTPase-activating protein AGE1 XP_022630490.1 37323 D 1245769 CDS LALA0_S11e00628g 34687831 40354..41847 Unknown 1 NW_019212889.1 similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis; uncharacterized protein 41847 34687831 LALA0_S11e00628g Lachancea lanzarotensis uncharacterized protein XP_022630491.1 40354 D 1245769 CDS LALA0_S11e00650g 34687832 42077..43513 Unknown 1 NW_019212889.1 similar to uniprot|P08459 Saccharomyces cerevisiae YDR522C (ohnolog of YCL048W) SPS2 Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component; uncharacterized protein 43513 34687832 LALA0_S11e00650g Lachancea lanzarotensis uncharacterized protein XP_022630492.1 42077 D 1245769 CDS LALA0_S11e00672g 34687833 44581..46896 Unknown 1 NW_019212889.1 similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C URC2 Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism; uncharacterized protein 46896 34687833 LALA0_S11e00672g Lachancea lanzarotensis uncharacterized protein XP_022630493.1 44581 D 1245769 CDS LALA0_S11e00694g 34687834 complement(46929..47714) Unknown 1 NW_019212889.1 similar to uniprot|P25576 Saccharomyces cerevisiae YCL047C POF1 Protein involved in the filamentation pathway; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; nicotinamide-nucleotide adenylyltransferase 47714 34687834 LALA0_S11e00694g Lachancea lanzarotensis nicotinamide-nucleotide adenylyltransferase XP_022630494.1 46929 R 1245769 CDS LALA0_S11e00716g 34687835 complement(48578..48994) Unknown 1 NW_019212889.1 similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; peptidylprolyl isomerase family protein FPR2 48994 34687835 LALA0_S11e00716g Lachancea lanzarotensis peptidylprolyl isomerase family protein FPR2 XP_022630495.1 48578 R 1245769 CDS LALA0_S11e00738g 34687836 complement(49683..51911) Unknown 1 NW_019212889.1 similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C EMC1 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; uncharacterized protein 51911 34687836 LALA0_S11e00738g Lachancea lanzarotensis uncharacterized protein XP_022630496.1 49683 R 1245769 CDS LALA0_S11e00760g 34687837 complement(52104..53315) Unknown 1 NW_019212889.1 similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C MGR1 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA; uncharacterized protein 53315 34687837 LALA0_S11e00760g Lachancea lanzarotensis uncharacterized protein XP_022630497.1 52104 R 1245769 CDS LALA0_S11e00782g 34687838 complement(53516..55084) Unknown 1 NW_019212889.1 similar to uniprot|P32474 Saccharomyces cerevisiae YDR518W (ohnolog of YCL043C) EUG1 Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER; protein disulfide isomerase PDI1 55084 34687838 LALA0_S11e00782g Lachancea lanzarotensis protein disulfide isomerase PDI1 XP_022630498.1 53516 R 1245769 CDS LALA0_S11e00804g 34687839 complement(55644..56798) Unknown 1 NW_019212889.1 similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; uncharacterized protein 56798 34687839 LALA0_S11e00804g Lachancea lanzarotensis uncharacterized protein XP_022630499.1 55644 R 1245769 CDS LALA0_S11e00826g 34687840 57635..59119 Unknown 1 NW_019212889.1 highly similar to uniprot|Q04409 Saccharomyces cerevisiae YDR516C (ohnolog of YCL040W) EMI2 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p; uncharacterized protein 59119 34687840 LALA0_S11e00826g Lachancea lanzarotensis uncharacterized protein XP_022630500.1 57635 D 1245769 CDS LALA0_S11e00848g 34687841 59491..61743 Unknown 1 NW_019212889.1 similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W GID7 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions; glucose-induced degradation complex subunit GID7 61743 34687841 LALA0_S11e00848g Lachancea lanzarotensis glucose-induced degradation complex subunit GID7 XP_022630501.1 59491 D 1245769 CDS LALA0_S11e00870g 34687842 complement(61816..63327) Unknown 1 NW_019212889.1 similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; uncharacterized protein 63327 34687842 LALA0_S11e00870g Lachancea lanzarotensis uncharacterized protein XP_022630502.1 61816 R 1245769 CDS LALA0_S11e00892g 34687843 complement(64668..66164) Unknown 1 NW_019212889.1 weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515W (ohnolog of YCL037C) SLF1 RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; uncharacterized protein 66164 34687843 LALA0_S11e00892g Lachancea lanzarotensis uncharacterized protein XP_022630503.1 64668 R 1245769 CDS LALA0_S11e00914g 34687844 66788..68185 Unknown 1 NW_019212889.1 similar to uniprot|P25370 Saccharomyces cerevisiae YDR514C (ohnolog of YCL036W) Protein of unknown function that localizes to mitochondria; overexpression of YDR514C affects endocytic protein trafficking; uncharacterized protein 68185 34687844 LALA0_S11e00914g Lachancea lanzarotensis uncharacterized protein XP_022630504.1 66788 D 1245769 CDS LALA0_S11e00936g 34687845 68854..69390 Unknown 1 NW_019212889.1 hypothetical protein; uncharacterized protein 69390 34687845 LALA0_S11e00936g Lachancea lanzarotensis uncharacterized protein XP_022630505.1 68854 D 1245769 CDS LALA0_S11e00958g 34687846 69464..71203 Unknown 1 NW_019212889.1 weakly similar to uniprot|G8ZQQ7 Torulaspora delbrueckii TDEL0C06550 hypothetical protein; uncharacterized protein 71203 34687846 LALA0_S11e00958g Lachancea lanzarotensis uncharacterized protein XP_022630506.1 69464 D 1245769 CDS LALA0_S11e00980g 34687847 complement(71941..72360) Unknown 1 NW_019212889.1 similar to uniprot|P17695 Saccharomyces cerevisiae YDR513W (ohnolog of YCL035C) GRX2 Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; dithiol glutaredoxin GRX1 72360 34687847 LALA0_S11e00980g Lachancea lanzarotensis dithiol glutaredoxin GRX1 XP_022630507.1 71941 R 1245769 CDS LALA0_S11e01002g 34687848 72695..73699 Unknown 1 NW_019212889.1 similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat; uncharacterized protein 73699 34687848 LALA0_S11e01002g Lachancea lanzarotensis uncharacterized protein XP_022630508.1 72695 D 1245769 CDS LALA0_S11e01024g 34687849 complement(73822..74313) Unknown 1 NW_019212889.1 similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C MXR2 Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan; peptide-methionine (R)-S-oxide reductase 74313 34687849 LALA0_S11e01024g Lachancea lanzarotensis peptide-methionine (R)-S-oxide reductase XP_022630509.1 73822 R 1245769 CDS LALA0_S11e01046g 34687850 74510..74776 Unknown 1 NW_019212889.1 some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C EMI1 Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; uncharacterized protein 74776 34687850 LALA0_S11e01046g Lachancea lanzarotensis uncharacterized protein XP_022630510.1 74510 D 1245769 CDS LALA0_S11e01068g 34687851 76303..77262 Unknown 1 NW_019212889.1 similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; uncharacterized protein 77262 34687851 LALA0_S11e01068g Lachancea lanzarotensis uncharacterized protein XP_022630511.1 76303 D 1245769 CDS LALA0_S11e01090g 34687852 complement(77369..78277) Unknown 1 NW_019212889.1 similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 Essential protein involved in rRNA processing and ribosome biogenesis; uncharacterized protein 78277 34687852 LALA0_S11e01090g Lachancea lanzarotensis uncharacterized protein XP_022630512.1 77369 R 1245769 CDS LALA0_S11e01112g 34687853 complement(78838..79224) Unknown 1 NW_019212889.1 similar to uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes; uncharacterized protein 79224 34687853 LALA0_S11e01112g Lachancea lanzarotensis uncharacterized protein XP_022630513.1 78838 R 1245769 CDS LALA0_S11e01134g 34687854 complement(80057..81301) Unknown 1 NW_019212889.1 weakly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; prion domain-containing protein RNQ1 81301 34687854 LALA0_S11e01134g Lachancea lanzarotensis prion domain-containing protein RNQ1 XP_022630514.1 80057 R 1245769 CDS LALA0_S11e01156g 34687855 81616..82965 Unknown 1 NW_019212889.1 similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170; uncharacterized protein 82965 34687855 LALA0_S11e01156g Lachancea lanzarotensis uncharacterized protein XP_022630515.1 81616 D 1245769 CDS LALA0_S11e01178g 34687856 83280..85709 Unknown 1 NW_019212889.1 highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C HIS4 Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 85709 34687856 LALA0_S11e01178g Lachancea lanzarotensis trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase XP_022630516.1 83280 D 1245769 CDS LALA0_S11e01200g 34687857 complement(85983..86870) Unknown 1 NW_019212889.1 weakly similar to uniprot|P47032 Saccharomyces cerevisiae YJL079C (ohnolog of YKR013W) PRY1 Protein of unknown function; uncharacterized protein 86870 34687857 LALA0_S11e01200g Lachancea lanzarotensis uncharacterized protein XP_022630517.1 85983 R 1245769 CDS LALA0_S11e01222g 34687858 89896..91602 Unknown 1 NW_019212889.1 weakly similar to uniprot|P11710 Saccharomyces cerevisiae YCL027W FUS1 Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate; uncharacterized protein 91602 34687858 LALA0_S11e01222g Lachancea lanzarotensis uncharacterized protein XP_022630518.1 89896 D 1245769 CDS LALA0_S11e01244g 34687859 complement(91635..92222) Unknown 1 NW_019212889.1 similar to uniprot|P37261 Saccharomyces cerevisiae YCL026C-A FRM2 Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases; uncharacterized protein 92222 34687859 LALA0_S11e01244g Lachancea lanzarotensis uncharacterized protein XP_022630519.1 91635 R 1245769 CDS LALA0_S11e01266g 34687860 complement(93552..95315) Unknown 1 NW_019212889.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C (ohnolog of YCL025C) GNP1 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; uncharacterized protein 95315 34687860 LALA0_S11e01266g Lachancea lanzarotensis uncharacterized protein XP_022630520.1 93552 R 1245769 CDS LALA0_S11e01288g 34687861 complement(96258..98054) Unknown 1 NW_019212889.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C (ohnolog of YCL025C) GNP1 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; uncharacterized protein 98054 34687861 LALA0_S11e01288g Lachancea lanzarotensis uncharacterized protein XP_022630521.1 96258 R 1245769 CDS LALA0_S11e01310g 34687862 99211..99495 Unknown 1 NW_019212889.1 highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W SMT3 Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2; SUMO family protein SMT3 99495 34687862 LALA0_S11e01310g Lachancea lanzarotensis SUMO family protein SMT3 XP_022630522.1 99211 D 1245769 CDS LALA0_S11e01332g 34687863 100331..102742 Unknown 1 NW_019212889.1 putative transposase of the Rover hAT-like DNA transposon 102742 34687863 LALA0_S11e01332g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022630523.1 100331 D 1245769 CDS LALA0_S11e01354g 34687864 103767..107264 Unknown 1 NW_019212889.1 similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C (ohnolog of YCL024W) GIN4 Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p; uncharacterized protein 107264 34687864 LALA0_S11e01354g Lachancea lanzarotensis uncharacterized protein XP_022630524.1 103767 D 1245769 CDS LALA0_S11e01376g 34687865 107794..109659 Unknown 1 NW_019212889.1 similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Possible membrane-localized protein; uncharacterized protein 109659 34687865 LALA0_S11e01376g Lachancea lanzarotensis uncharacterized protein XP_022630525.1 107794 D 1245769 CDS LALA0_S11e01398g 34687866 111065..113275 Unknown 1 NW_019212889.1 similar to uniprot|P50896 Saccharomyces cerevisiae YDR505C (ohnolog of YLR177W) PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; uncharacterized protein 113275 34687866 LALA0_S11e01398g Lachancea lanzarotensis uncharacterized protein XP_022630526.1 111065 D 1245769 CDS LALA0_S11e01420g 34687867 complement(113542..114168) Unknown 1 NW_019212889.1 similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; uncharacterized protein 114168 34687867 LALA0_S11e01420g Lachancea lanzarotensis uncharacterized protein XP_022630527.1 113542 R 1245769 CDS LALA0_S11e01442g 34687868 114936..115733 Unknown 1 NW_019212889.1 similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA; phosphatidate phosphatase LPP1 115733 34687868 LALA0_S11e01442g Lachancea lanzarotensis phosphatidate phosphatase LPP1 XP_022630528.1 114936 D 1245769 CDS LALA0_S11e01464g 34687869 117426..118574 Unknown 1 NW_019212889.1 highly similar to uniprot|P19358 Saccharomyces cerevisiae YDR502C (ohnolog of YLR180W) SAM2 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p); uncharacterized protein 118574 34687869 LALA0_S11e01464g Lachancea lanzarotensis uncharacterized protein XP_022630529.1 117426 D 1245769 CDS LALA0_S11e01486g 34687870 complement(118888..120003) Unknown 1 NW_019212889.1 weakly similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain; uncharacterized protein 120003 34687870 LALA0_S11e01486g Lachancea lanzarotensis uncharacterized protein XP_022630530.1 118888 R 1245769 CDS LALA0_S11e01508g 34687871 120690..121769 Unknown 1 NW_019212889.1 similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W YIM1 Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 121769 34687871 LALA0_S11e01508g Lachancea lanzarotensis uncharacterized protein XP_022630531.1 120690 D 1245769 CDS LALA0_S11e01530g 34687872 123201..125306 Unknown 1 NW_019212889.1 similar to uniprot|P09959 Saccharomyces cerevisiae YLR182W SWI6 Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; transcriptional regulator SWI6 125306 34687872 LALA0_S11e01530g Lachancea lanzarotensis transcriptional regulator SWI6 XP_022630532.1 123201 D 1245769 CDS LALA0_S11e01552g 34687873 complement(125438..127213) Unknown 1 NW_019212889.1 weakly similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W (ohnolog of YLR183C) PLM2 Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4; uncharacterized protein 127213 34687873 LALA0_S11e01552g Lachancea lanzarotensis uncharacterized protein XP_022630533.1 125438 R 1245769 CDS LALA0_S11e01574g 34687874 complement(127972..129654) Unknown 1 NW_019212889.1 similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene; uncharacterized protein 129654 34687874 LALA0_S11e01574g Lachancea lanzarotensis uncharacterized protein XP_022630534.1 127972 R 1245769 CDS LALA0_S11e01596g 34687875 130620..131789 Unknown 1 NW_019212889.1 similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; uncharacterized protein 131789 34687875 LALA0_S11e01596g Lachancea lanzarotensis uncharacterized protein XP_022630535.1 130620 D 1245769 CDS LALA0_S11e01618g 34687876 132233..133144 Unknown 1 NW_019212889.1 similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; uncharacterized protein 133144 34687876 LALA0_S11e01618g Lachancea lanzarotensis uncharacterized protein XP_022630536.1 132233 D 1245769 CDS LALA0_S11e01640g 34687877 join(134177..134183,134542..134801) Unknown 1 NW_019212889.1 highly similar to uniprot|P51402 Saccharomyces cerevisiae YDR500C (ohnolog of YLR185W) RPL37B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein; 60S ribosomal protein eL37 134801 34687877 LALA0_S11e01640g Lachancea lanzarotensis 60S ribosomal protein eL37 XP_022630537.1 134177 D 1245769 CDS LALA0_S11e01662g 34687878 complement(135012..137129) Unknown 1 NW_019212889.1 similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; uncharacterized protein 137129 34687878 LALA0_S11e01662g Lachancea lanzarotensis uncharacterized protein XP_022630538.1 135012 R 1245769 CDS LALA0_S11e01684g 34687879 137862..138620 Unknown 1 NW_019212889.1 highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers; uncharacterized protein 138620 34687879 LALA0_S11e01684g Lachancea lanzarotensis uncharacterized protein XP_022630539.1 137862 D 1245769 CDS LALA0_S11e01706g 34687880 138861..140759 Unknown 1 NW_019212889.1 similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p; pheromone-regulated protein PRM1 140759 34687880 LALA0_S11e01706g Lachancea lanzarotensis pheromone-regulated protein PRM1 XP_022630540.1 138861 D 1245769 CDS LALA0_S11e01728g 34687881 141178..144252 Unknown 1 NW_019212889.1 similar to uniprot|P53836 Saccharomyces cerevisiae YNL278W (ohnolog of YLR187W) CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; uncharacterized protein 144252 34687881 LALA0_S11e01728g Lachancea lanzarotensis uncharacterized protein XP_022630541.1 141178 D 1245769 CDS LALA0_S11e01750g 34687882 144671..146851 Unknown 1 NW_019212889.1 similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress; ATP-binding cassette permease MDL1 146851 34687882 LALA0_S11e01750g Lachancea lanzarotensis ATP-binding cassette permease MDL1 XP_022630542.1 144671 D 1245769 CDS LALA0_S11e01772g 34687883 147313..148773 Unknown 1 NW_019212889.1 highly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; homoserine O-acetyltransferase 148773 34687883 LALA0_S11e01772g Lachancea lanzarotensis homoserine O-acetyltransferase XP_022630543.1 147313 D 1245769 CDS LALA0_S11e01794g 34687884 complement(148883..152719) Unknown 1 NW_019212889.1 similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy; sterol 3-beta-glucosyltransferase 152719 34687884 LALA0_S11e01794g Lachancea lanzarotensis sterol 3-beta-glucosyltransferase XP_022630544.1 148883 R 1245769 CDS LALA0_S11e01816g 34687885 complement(153344..154669) Unknown 1 NW_019212889.1 similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; inositol phosphosphingolipid phospholipase 154669 34687885 LALA0_S11e01816g Lachancea lanzarotensis inositol phosphosphingolipid phospholipase XP_022630545.1 153344 R 1245769 CDS LALA0_S11e01838g 34687886 join(154945..155149,155217..155701) Unknown 1 NW_019212889.1 weakly similar to uniprot|P40014 Saccharomyces cerevisiae YER018C SPC25 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; uncharacterized protein 155701 34687886 LALA0_S11e01838g Lachancea lanzarotensis uncharacterized protein XP_022630546.1 154945 D 1245769 CDS LALA0_S11e01860g 34687887 155847..156911 Unknown 1 NW_019212889.1 similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1; uncharacterized protein 156911 34687887 LALA0_S11e01860g Lachancea lanzarotensis uncharacterized protein XP_022630547.1 155847 D 1245769 CDS LALA0_S11e01882g 34687888 157570..159210 Unknown 1 NW_019212889.1 similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W BOR1 Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; uncharacterized protein 159210 34687888 LALA0_S11e01882g Lachancea lanzarotensis uncharacterized protein XP_022630548.1 157570 D 1245769 CDS LALA0_S11e01904g 34687889 161478..162524 Unknown 1 NW_019212889.1 similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; glyoxylate reductase 162524 34687889 LALA0_S11e01904g Lachancea lanzarotensis glyoxylate reductase XP_022630549.1 161478 D 1245769 CDS LALA0_S11e01926g 34687890 complement(162672..163034) Unknown 1 NW_019212889.1 similar to uniprot|P25361 Saccharomyces cerevisiae YCR043C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene; uncharacterized protein 163034 34687890 LALA0_S11e01926g Lachancea lanzarotensis uncharacterized protein XP_022630550.1 162672 R 1245769 CDS LALA0_S11e01948g 34687891 164419..168693 Unknown 1 NW_019212889.1 similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation; uncharacterized protein 168693 34687891 LALA0_S11e01948g Lachancea lanzarotensis uncharacterized protein XP_022630551.1 164419 D 1245769 CDS LALA0_S11e01970g 34687892 168956..171028 Unknown 1 NW_019212889.1 weakly similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W SLP1 Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; uncharacterized protein 171028 34687892 LALA0_S11e01970g Lachancea lanzarotensis uncharacterized protein XP_022630552.1 168956 D 1245769 CDS LALA0_S11e01992g 34687893 complement(171675..172757) Unknown 1 NW_019212889.1 some similarities with uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; uncharacterized protein 172757 34687893 LALA0_S11e01992g Lachancea lanzarotensis uncharacterized protein XP_022630553.1 171675 R 1245769 CDS LALA0_S11e02014g 34687894 173690..174826 Unknown 1 NW_019212889.1 weakly similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores; uncharacterized protein 174826 34687894 LALA0_S11e02014g Lachancea lanzarotensis uncharacterized protein XP_022630554.1 173690 D 1245769 CDS LALA0_S11e02036g 34687895 175536..179153 Unknown 1 NW_019212889.1 similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; uncharacterized protein 179153 34687895 LALA0_S11e02036g Lachancea lanzarotensis uncharacterized protein XP_022630555.1 175536 D 1245769 CDS LALA0_S11e02058g 34687896 complement(179189..180607) Unknown 1 NW_019212889.1 similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 180607 34687896 LALA0_S11e02058g Lachancea lanzarotensis uncharacterized protein XP_022630556.1 179189 R 1245769 CDS LALA0_S11e02080g 34687897 complement(180780..182948) Unknown 1 NW_019212889.1 similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles; guanine nucleotide exchange factor SEC2 182948 34687897 LALA0_S11e02080g Lachancea lanzarotensis guanine nucleotide exchange factor SEC2 XP_022630557.1 180780 R 1245769 CDS LALA0_S11e02102g 34687898 complement(183276..189296) Unknown 1 NW_019212889.1 similar to uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1; formin BNI1 189296 34687898 LALA0_S11e02102g Lachancea lanzarotensis formin BNI1 XP_022630558.1 183276 R 1245769 CDS LALA0_S11e02124g 34687899 191271..192992 Unknown 1 NW_019212889.1 similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids; lysine permease 192992 34687899 LALA0_S11e02124g Lachancea lanzarotensis lysine permease XP_022630559.1 191271 D 1245769 CDS LALA0_S11e02146g 34687900 193543..196602 Unknown 1 NW_019212889.1 similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; 1-phosphatidylinositol 4-kinase 196602 34687900 LALA0_S11e02146g Lachancea lanzarotensis 1-phosphatidylinositol 4-kinase XP_022630560.1 193543 D 1245769 CDS LALA0_S11e02168g 34687901 197165..198331 Unknown 1 NW_019212889.1 similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W TAM41 Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud; uncharacterized protein 198331 34687901 LALA0_S11e02168g Lachancea lanzarotensis uncharacterized protein XP_022630561.1 197165 D 1245769 CDS LALA0_S11e02190g 34687902 complement(198413..199210) Unknown 1 NW_019212889.1 similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p; uncharacterized protein 199210 34687902 LALA0_S11e02190g Lachancea lanzarotensis uncharacterized protein XP_022630562.1 198413 R 1245769 CDS LALA0_S11e02212g 34687903 complement(199571..202699) Unknown 1 NW_019212889.1 similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C TFC4 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102; transcription factor TFIIIC subunit TFC4 202699 34687903 LALA0_S11e02212g Lachancea lanzarotensis transcription factor TFIIIC subunit TFC4 XP_022630563.1 199571 R 1245769 CDS LALA0_S11e02234g 34687904 203212..204285 Unknown 1 NW_019212889.1 similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol; polyubiquitin-binding protein UFD1 204285 34687904 LALA0_S11e02234g Lachancea lanzarotensis polyubiquitin-binding protein UFD1 XP_022630564.1 203212 D 1245769 CDS LALA0_S11e02256g 34687905 complement(204376..207957) Unknown 1 NW_019212889.1 similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains; uncharacterized protein 207957 34687905 LALA0_S11e02256g Lachancea lanzarotensis uncharacterized protein XP_022630565.1 204376 R 1245769 CDS LALA0_S11e02278g 34687906 complement(209009..210070) Unknown 1 NW_019212889.1 similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition; phosphatidylinositol transporter 210070 34687906 LALA0_S11e02278g Lachancea lanzarotensis phosphatidylinositol transporter XP_022630566.1 209009 R 1245769 CDS LALA0_S11e02300g 34687907 complement(210258..211106) Unknown 1 NW_019212889.1 similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C CWC23 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p; U2-type spliceosomal complex subunit CWC23 211106 34687907 LALA0_S11e02300g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC23 XP_022630567.1 210258 R 1245769 CDS LALA0_S11e02322g 34687908 complement(211359..212306) Unknown 1 NW_019212889.1 similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C YIF1 Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3; protein transporter YIF1 212306 34687908 LALA0_S11e02322g Lachancea lanzarotensis protein transporter YIF1 XP_022630568.1 211359 R 1245769 CDS LALA0_S11e02344g 34687909 213467..220099 Unknown 1 NW_019212889.1 similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p; DNA polymerase epsilon catalytic subunit 220099 34687909 LALA0_S11e02344g Lachancea lanzarotensis DNA polymerase epsilon catalytic subunit XP_022630569.1 213467 D 1245769 CDS LALA0_S11e02366g 34687910 220261..221682 Unknown 1 NW_019212889.1 similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; origin recognition complex subunit 5 221682 34687910 LALA0_S11e02366g Lachancea lanzarotensis origin recognition complex subunit 5 XP_022630570.1 220261 D 1245769 CDS LALA0_S11e02388g 34687911 221830..222912 Unknown 1 NW_019212889.1 weakly similar to uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication; U5 snRNP complex subunit LIN1 222912 34687911 LALA0_S11e02388g Lachancea lanzarotensis U5 snRNP complex subunit LIN1 XP_022630571.1 221830 D 1245769 CDS LALA0_S11e02410g 34687912 complement(222946..223437) Unknown 1 NW_019212889.1 similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm; ribosome biosynthesis protein LTO1 223437 34687912 LALA0_S11e02410g Lachancea lanzarotensis ribosome biosynthesis protein LTO1 XP_022630572.1 222946 R 1245769 CDS LALA0_S11e02432g 34687913 complement(223792..224013) Unknown 1 NW_019212889.1 highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; copper metallochaperone ATX1 224013 34687913 LALA0_S11e02432g Lachancea lanzarotensis copper metallochaperone ATX1 XP_022630573.1 223792 R 1245769 CDS LALA0_S11e02454g 34687914 complement(224367..226607) Unknown 1 NW_019212889.1 similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; uncharacterized protein 226607 34687914 LALA0_S11e02454g Lachancea lanzarotensis uncharacterized protein XP_022630574.1 224367 R 1245769 CDS LALA0_S11e02476g 34687915 complement(227246..230911) Unknown 1 NW_019212889.1 similar to uniprot|P38851 Saccharomyces cerevisiae YHR155W (ohnolog of YNL257C) YSP1 Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; uncharacterized protein 230911 34687915 LALA0_S11e02476g Lachancea lanzarotensis uncharacterized protein XP_022630575.1 227246 R 1245769 CDS LALA0_S11e02498g 34687916 complement(231166..232395) Unknown 1 NW_019212889.1 similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; triglyceride lipase 232395 34687916 LALA0_S11e02498g Lachancea lanzarotensis triglyceride lipase XP_022630576.1 231166 R 1245769 CDS LALA0_S11e02520g 34687917 complement(232583..233572) Unknown 1 NW_019212889.1 some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; uncharacterized protein 233572 34687917 LALA0_S11e02520g Lachancea lanzarotensis uncharacterized protein XP_022630577.1 232583 R 1245769 CDS LALA0_S11e02542g 34687918 complement(233717..235141) Unknown 1 NW_019212889.1 similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS); uncharacterized protein 235141 34687918 LALA0_S11e02542g Lachancea lanzarotensis uncharacterized protein XP_022630578.1 233717 R 1245769 CDS LALA0_S11e02564g 34687919 235767..238181 Unknown 1 NW_019212889.1 similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities; trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 238181 34687919 LALA0_S11e02564g Lachancea lanzarotensis trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 XP_022630579.1 235767 D 1245769 CDS LALA0_S11e02586g 34687920 complement(238477..238995) Unknown 1 NW_019212889.1 similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C GIS2 Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2; mRNA-binding translational activator GIS2 238995 34687920 LALA0_S11e02586g Lachancea lanzarotensis mRNA-binding translational activator GIS2 XP_022630580.1 238477 R 1245769 CDS LALA0_S11e02608g 34687921 complement(239995..241203) Unknown 1 NW_019212889.1 weakly similar to uniprot|P53850 Saccharomyces cerevisiae YNL254C RTC4 Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; uncharacterized protein 241203 34687921 LALA0_S11e02608g Lachancea lanzarotensis uncharacterized protein XP_022630581.1 239995 R 1245769 CDS LALA0_S11e02630g 34687922 242078..243307 Unknown 1 NW_019212889.1 weakly similar to uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 Protein involved in mRNA export, component of the transcription export (TREX) complex; uncharacterized protein 243307 34687922 LALA0_S11e02630g Lachancea lanzarotensis uncharacterized protein XP_022630582.1 242078 D 1245769 CDS LALA0_S11e02652g 34687923 complement(243470..244291) Unknown 1 NW_019212889.1 similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL46 244291 34687923 LALA0_S11e02652g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL46 XP_022630583.1 243470 R 1245769 CDS LALA0_S11e02674g 34687924 complement(245111..246865) Unknown 1 NW_019212889.1 similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs); interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; required for 3' end maturation of nonpolyadenylated RNAs; Nrd1 complex RNA-binding subunit 246865 34687924 LALA0_S11e02674g Lachancea lanzarotensis Nrd1 complex RNA-binding subunit XP_022630584.1 245111 R 1245769 CDS LALA0_S11e02696g 34687925 247564..251457 Unknown 1 NW_019212889.1 similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; MRX complex DNA-binding subunit 251457 34687925 LALA0_S11e02696g Lachancea lanzarotensis MRX complex DNA-binding subunit XP_022630585.1 247564 D 1245769 CDS LALA0_S11e02718g 34687926 complement(251482..253074) Unknown 1 NW_019212889.1 similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 253074 34687926 LALA0_S11e02718g Lachancea lanzarotensis uncharacterized protein XP_022630586.1 251482 R 1245769 CDS LALA0_S11e02740g 34687927 complement(253218..254456) Unknown 1 NW_019212889.1 highly similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit RPA49 254456 34687927 LALA0_S11e02740g Lachancea lanzarotensis DNA-directed RNA polymerase I subunit RPA49 XP_022630587.1 253218 R 1245769 CDS LALA0_S11e02762g 34687928 254904..255395 Unknown 1 NW_019212889.1 similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein; uncharacterized protein 255395 34687928 LALA0_S11e02762g Lachancea lanzarotensis uncharacterized protein XP_022630588.1 254904 D 1245769 CDS LALA0_S11e02784g 34687929 complement(255464..257284) Unknown 1 NW_019212889.1 similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 257284 34687929 LALA0_S11e02784g Lachancea lanzarotensis uncharacterized protein XP_022630589.1 255464 R 1245769 CDS LALA0_S11e02806g 34687930 258502..260832 Unknown 1 NW_019212889.1 similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; cysteine--tRNA ligase 260832 34687930 LALA0_S11e02806g Lachancea lanzarotensis cysteine--tRNA ligase XP_022630590.1 258502 D 1245769 CDS LALA0_S11e02828g 34687931 join(261194..261210,261276..262080) Unknown 1 NW_019212889.1 similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75 NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; uncharacterized protein 262080 34687931 LALA0_S11e02828g Lachancea lanzarotensis uncharacterized protein XP_022630591.1 261194 D 1245769 CDS LALA0_S11e02850g 34687932 complement(262126..262704) Unknown 1 NW_019212889.1 similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C CWC25 Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p; U2-type spliceosomal complex subunit CWC25 262704 34687932 LALA0_S11e02850g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC25 XP_022630592.1 262126 R 1245769 CDS LALA0_S11e02872g 34687933 complement(263162..263488) Unknown 1 NW_019212889.1 highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; translation initiation factor eIF1 263488 34687933 LALA0_S11e02872g Lachancea lanzarotensis translation initiation factor eIF1 XP_022630593.1 263162 R 1245769 CDS LALA0_S11e02894g 34687934 264762..266357 Unknown 1 NW_019212889.1 some similarities with uniprot|P33338 Saccharomyces cerevisiae YNL243W SLA2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; 266357 34687934 LALA0_S11e02894g Lachancea lanzarotensis 264762 D 1245769 CDS LALA0_S11e02938g 34687935 complement(266560..268104) Unknown 1 NW_019212889.1 similar to uniprot|C5DKC3 Lachancea thermotolerans KLTH0F03454g hypothetical protein; uncharacterized protein 268104 34687935 LALA0_S11e02938g Lachancea lanzarotensis uncharacterized protein XP_022630594.1 266560 R 1245769 CDS LALA0_S11e02960g 34687936 268823..269650 Unknown 1 NW_019212889.1 weakly similar to uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import; ubiquitin-protein ligase peroxin 2 269650 34687936 LALA0_S11e02960g Lachancea lanzarotensis ubiquitin-protein ligase peroxin 2 XP_022630595.1 268823 D 1245769 CDS LALA0_S11e02982g 34687937 269897..271828 Unknown 1 NW_019212889.1 weakly similar to uniprot|P07252 Saccharomyces cerevisiae YJL209W CBP1 Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p; uncharacterized protein 271828 34687937 LALA0_S11e02982g Lachancea lanzarotensis uncharacterized protein XP_022630596.1 269897 D 1245769 CDS LALA0_S11e03004g 34687938 complement(271882..272907) Unknown 1 NW_019212889.1 similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; ribonuclease 272907 34687938 LALA0_S11e03004g Lachancea lanzarotensis ribonuclease XP_022630597.1 271882 R 1245769 CDS LALA0_S11e03026g 34687939 complement(273167..279085) Unknown 1 NW_019212889.1 similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C LAA1 AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene; uncharacterized protein 279085 34687939 LALA0_S11e03026g Lachancea lanzarotensis uncharacterized protein XP_022630598.1 273167 R 1245769 CDS LALA0_S11e03048g 34687940 complement(279551..281731) Unknown 1 NW_019212889.1 weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; uncharacterized protein 281731 34687940 LALA0_S11e03048g Lachancea lanzarotensis uncharacterized protein XP_022630599.1 279551 R 1245769 CDS LALA0_S11e03070g 34687941 complement(join(281964..282114,282218..282249)) Unknown 1 NW_019212889.1 similar to uniprot|Q02820 Saccharomyces cerevisiae YJL205C NCE101 Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences; uncharacterized protein 282249 34687941 LALA0_S11e03070g Lachancea lanzarotensis uncharacterized protein XP_022630600.1 281964 R 1245769 CDS LALA0_S11e03092g 34687942 282438..282845 Unknown 1 NW_019212889.1 weakly similar to uniprot|Q12338 Saccharomyces cerevisiae YLR154C RNH203 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome; uncharacterized protein 282845 34687942 LALA0_S11e03092g Lachancea lanzarotensis uncharacterized protein XP_022630601.1 282438 D 1245769 CDS LALA0_S11e03114g 34687943 283199..284209 Unknown 1 NW_019212889.1 similar to Lachancea thermotolerans KLTH0F03498g hypothetical protein; uncharacterized protein 284209 34687943 LALA0_S11e03114g Lachancea lanzarotensis uncharacterized protein XP_022630602.1 283199 D 1245769 CDS LALA0_S11e03136g 34687944 complement(284242..286557) Unknown 1 NW_019212889.1 similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; uncharacterized protein 286557 34687944 LALA0_S11e03136g Lachancea lanzarotensis uncharacterized protein XP_022630603.1 284242 R 1245769 CDS LALA0_S11e03158g 34687945 287158..288312 Unknown 1 NW_019212889.1 similar to uniprot|C5DKH7 Lachancea thermotolerans KLTH0F04752g hypothetical protein; uncharacterized protein 288312 34687945 LALA0_S11e03158g Lachancea lanzarotensis uncharacterized protein XP_022630604.1 287158 D 1245769 CDS LALA0_S11e03202g 34687947 288952..290805 Unknown 1 NW_019212889.1 similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p; uncharacterized protein 290805 34687947 LALA0_S11e03202g Lachancea lanzarotensis uncharacterized protein XP_022630605.1 288952 D 1245769 CDS LALA0_S11e03224g 34687948 291143..295429 Unknown 1 NW_019212889.1 some similarities with uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; Ras family guanine nucleotide exchange factor BUD5 295429 34687948 LALA0_S11e03224g Lachancea lanzarotensis Ras family guanine nucleotide exchange factor BUD5 XP_022630606.1 291143 D 1245769 CDS LALA0_S11e03246g 34687949 complement(295574..297934) Unknown 1 NW_019212889.1 highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C ACO2 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol; aconitate hydratase ACO2 297934 34687949 LALA0_S11e03246g Lachancea lanzarotensis aconitate hydratase ACO2 XP_022630607.1 295574 R 1245769 CDS LALA0_S11e03290g 34687951 299669..302383 Unknown 1 NW_019212889.1 similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C (ohnolog of YJL198W) PHO87 Low-affinity inorganicphosphate (Pi) transporter, involved in activation of PHOpathway; expression is independent of Pi concentration andPho4p activity; contains 12 membrane-spanning segments; SPX domain-containing inorganic phosphate transporter 302383 34687951 LALA0_S11e03290g Lachancea lanzarotensis SPX domain-containing inorganic phosphate transporter XP_022630608.1 299669 D 1245769 CDS LALA0_S11e03312g 34687952 303157..306549 Unknown 1 NW_019212889.1 similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins; uncharacterized protein 306549 34687952 LALA0_S11e03312g Lachancea lanzarotensis uncharacterized protein XP_022630609.1 303157 D 1245769 CDS LALA0_S11e03334g 34687953 complement(306676..307689) Unknown 1 NW_019212889.1 similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase; uncharacterized protein 307689 34687953 LALA0_S11e03334g Lachancea lanzarotensis uncharacterized protein XP_022630610.1 306676 R 1245769 CDS LALA0_S11e03356g 34687954 308784..309914 Unknown 1 NW_019212889.1 similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); exosome non-catalytic core subunit RRP43 309914 34687954 LALA0_S11e03356g Lachancea lanzarotensis exosome non-catalytic core subunit RRP43 XP_022630611.1 308784 D 1245769 CDS LALA0_S11e03378g 34687955 complement(310050..311078) Unknown 1 NW_019212889.1 highly similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W (ohnolog of YJL196C) FEN1 Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; uncharacterized protein 311078 34687955 LALA0_S11e03378g Lachancea lanzarotensis uncharacterized protein XP_022630612.1 310050 R 1245769 CDS LALA0_S11e03400g 34687956 complement(311733..315626) Unknown 1 NW_019212889.1 weakly similar to uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance; uncharacterized protein 315626 34687956 LALA0_S11e03400g Lachancea lanzarotensis uncharacterized protein XP_022630613.1 311733 R 1245769 CDS LALA0_S11e03422g 34687957 318326..319912 Unknown 1 NW_019212889.1 similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; AAA family ATPase CDC6 319912 34687957 LALA0_S11e03422g Lachancea lanzarotensis AAA family ATPase CDC6 XP_022630614.1 318326 D 1245769 CDS LALA0_S11e03444g 34687958 complement(320023..326346) Unknown 1 NW_019212889.1 similar to uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1 PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting; uncharacterized protein 326346 34687958 LALA0_S11e03444g Lachancea lanzarotensis uncharacterized protein XP_022630615.1 320023 R 1245769 CDS LALA0_S11e03466g 34687959 complement(326617..327351) Unknown 1 NW_019212889.1 similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER; uncharacterized protein 327351 34687959 LALA0_S11e03466g Lachancea lanzarotensis uncharacterized protein XP_022630616.1 326617 R 1245769 CDS LALA0_S11e03488g 34687960 join(328375..328384,328762..329168) Unknown 1 NW_019212889.1 highly similar to uniprot|P06367 Saccharomyces cerevisiae YCR031C (ohnolog of YJL191W) RPS14A Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins; 40S ribosomal protein uS11 329168 34687960 LALA0_S11e03488g Lachancea lanzarotensis 40S ribosomal protein uS11 XP_022630617.1 328375 D 1245769 CDS LALA0_S11e03510g 34687961 complement(329702..330094) Unknown 1 NW_019212889.1 highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins; 40S ribosomal protein uS8 330094 34687961 LALA0_S11e03510g Lachancea lanzarotensis 40S ribosomal protein uS8 XP_022630618.1 329702 R 1245769 CDS LALA0_S11e03532g 34687962 join(330629..330634,331051..331200) Unknown 1 NW_019212889.1 highly similar to uniprot|P04650 Saccharomyces cerevisiae YJL189W RPL39 Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; 60S ribosomal protein eL39 331200 34687962 LALA0_S11e03532g Lachancea lanzarotensis 60S ribosomal protein eL39 XP_022630619.1 330629 D 1245769 CDS LALA0_S11e03554g 34687963 complement(331893..334142) Unknown 1 NW_019212889.1 similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate; tyrosine protein kinase SWE1 334142 34687963 LALA0_S11e03554g Lachancea lanzarotensis tyrosine protein kinase SWE1 XP_022630620.1 331893 R 1245769 CDS LALA0_S11e03576g 34687964 337064..338731 Unknown 1 NW_019212889.1 similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; alpha-1,2-mannosyltransferase MNN5 338731 34687964 LALA0_S11e03576g Lachancea lanzarotensis alpha-1,2-mannosyltransferase MNN5 XP_022630621.1 337064 D 1245769 CDS LALA0_S11e03598g 34687965 339148..341670 Unknown 1 NW_019212889.1 similar to uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization; uncharacterized protein 341670 34687965 LALA0_S11e03598g Lachancea lanzarotensis uncharacterized protein XP_022630622.1 339148 D 1245769 CDS LALA0_S11e03620g 34687966 complement(341772..342662) Unknown 1 NW_019212889.1 weakly similar to uniprot|P46983 Saccharomyces cerevisiae YJL185C Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene; uncharacterized protein 342662 34687966 LALA0_S11e03620g Lachancea lanzarotensis uncharacterized protein XP_022630623.1 341772 R 1245769 CDS LALA0_S11e03642g 34687967 join(343537..343775,343857..343974) Unknown 1 NW_019212889.1 similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; uncharacterized protein 343974 34687967 LALA0_S11e03642g Lachancea lanzarotensis uncharacterized protein XP_022630624.1 343537 D 1245769 CDS LALA0_S11e03664g 34687968 344426..344806 Unknown 1 NW_019212889.1 similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response; chromatin DNA-binding EKC/KEOPS complex subunit GON7 344806 34687968 LALA0_S11e03664g Lachancea lanzarotensis chromatin DNA-binding EKC/KEOPS complex subunit GON7 XP_022630625.1 344426 D 1245769 CDS LALA0_S11e03686g 34687969 345073..346518 Unknown 1 NW_019212889.1 similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; uncharacterized protein 346518 34687969 LALA0_S11e03686g Lachancea lanzarotensis uncharacterized protein XP_022630626.1 345073 D 1245769 CDS LALA0_S11e03708g 34687970 347480..348724 Unknown 1 NW_019212889.1 similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; alpha-1,6-mannosyltransferase 348724 34687970 LALA0_S11e03708g Lachancea lanzarotensis alpha-1,6-mannosyltransferase XP_022630627.1 347480 D 1245769 CDS LALA0_S11e03730g 34687971 349392..351926 Unknown 1 NW_019212889.1 weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C (ohnolog of YJL181W) Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene; uncharacterized protein 351926 34687971 LALA0_S11e03730g Lachancea lanzarotensis uncharacterized protein XP_022630628.1 349392 D 1245769 CDS LALA0_S11e03752g 34687972 complement(351981..352949) Unknown 1 NW_019212889.1 similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency; ATP synthase complex assembly protein ATP12 352949 34687972 LALA0_S11e03752g Lachancea lanzarotensis ATP synthase complex assembly protein ATP12 XP_022630629.1 351981 R 1245769 CDS LALA0_S11e03774g 34687973 353259..353594 Unknown 1 NW_019212889.1 similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha-and gamma-tubulin; prefolding complex chaperone subunit 353594 34687973 LALA0_S11e03774g Lachancea lanzarotensis prefolding complex chaperone subunit XP_022630630.1 353259 D 1245769 CDS LALA0_S11e03796g 34687974 complement(353701..354534) Unknown 1 NW_019212889.1 similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site; uncharacterized protein 354534 34687974 LALA0_S11e03796g Lachancea lanzarotensis uncharacterized protein XP_022630631.1 353701 R 1245769 CDS LALA0_S11e03818g 34687975 join(355711..356019,356241..356486) Unknown 1 NW_019212889.1 highly similar to uniprot|P05740 Saccharomyces cerevisiae YKL180W (ohnolog of YJL177W) RPL17A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex); 60S ribosomal protein uL22 356486 34687975 LALA0_S11e03818g Lachancea lanzarotensis 60S ribosomal protein uL22 XP_022630632.1 355711 D 1245769 CDS LALA0_S11e03840g 34687976 complement(356779..358677) Unknown 1 NW_019212889.1 similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C COY1 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function; uncharacterized protein 358677 34687976 LALA0_S11e03840g Lachancea lanzarotensis uncharacterized protein XP_022630633.1 356779 R 1245769 CDS LALA0_S11e03862g 34687977 complement(359463..361985) Unknown 1 NW_019212889.1 similar to uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; uncharacterized protein 361985 34687977 LALA0_S11e03862g Lachancea lanzarotensis uncharacterized protein XP_022630634.1 359463 R 1245769 CDS LALA0_S11e03884g 34687978 363255..364103 Unknown 1 NW_019212889.1 similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects; uncharacterized protein 364103 34687978 LALA0_S11e03884g Lachancea lanzarotensis uncharacterized protein XP_022630635.1 363255 D 1245769 CDS LALA0_S11e03906g 34687979 complement(364352..364702) Unknown 1 NW_019212889.1 similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; uncharacterized protein 364702 34687979 LALA0_S11e03906g Lachancea lanzarotensis uncharacterized protein XP_022630636.1 364352 R 1245769 CDS LALA0_S11e03928g 34687980 365510..367222 Unknown 1 NW_019212889.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions; Gly-Xaa carboxypeptidase 367222 34687980 LALA0_S11e03928g Lachancea lanzarotensis Gly-Xaa carboxypeptidase XP_022630637.1 365510 D 1245769 CDS LALA0_S11e03950g 34687981 complement(367767..369155) Unknown 1 NW_019212889.1 similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR; uncharacterized protein 369155 34687981 LALA0_S11e03950g Lachancea lanzarotensis uncharacterized protein XP_022630638.1 367767 R 1245769 CDS LALA0_S11e03972g 34687982 complement(369623..370816) Unknown 1 NW_019212889.1 similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; uncharacterized protein 370816 34687982 LALA0_S11e03972g Lachancea lanzarotensis uncharacterized protein XP_022630639.1 369623 R 1245769 CDS LALA0_S11e03994g 34687983 complement(371153..371767) Unknown 1 NW_019212889.1 weakly similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor; uncharacterized protein 371767 34687983 LALA0_S11e03994g Lachancea lanzarotensis uncharacterized protein XP_022630640.1 371153 R 1245769 CDS LALA0_S11e04016g 34687984 complement(372212..374293) Unknown 1 NW_019212889.1 similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p; histone methyltransferase SET2 374293 34687984 LALA0_S11e04016g Lachancea lanzarotensis histone methyltransferase SET2 XP_022630641.1 372212 R 1245769 CDS LALA0_S11e04038g 34687985 complement(374724..376820) Unknown 1 NW_019212889.1 similar to uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; uncharacterized protein 376820 34687985 LALA0_S11e04038g Lachancea lanzarotensis uncharacterized protein XP_022630642.1 374724 R 1245769 CDS LALA0_S11e04060g 34687986 378063..379466 Unknown 1 NW_019212889.1 similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; Zn(2+) transporter ZRT3 379466 34687986 LALA0_S11e04060g Lachancea lanzarotensis Zn(2+) transporter ZRT3 XP_022630643.1 378063 D 1245769 CDS LALA0_S11e04082g 34687987 complement(379591..381342) Unknown 1 NW_019212889.1 similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles; uncharacterized protein 381342 34687987 LALA0_S11e04082g Lachancea lanzarotensis uncharacterized protein XP_022630644.1 379591 R 1245769 CDS LALA0_S11e04104g 34687988 join(382320..382342,382405..385216) Unknown 1 NW_019212889.1 similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2; U5 snRNP GTPase SNU114 385216 34687988 LALA0_S11e04104g Lachancea lanzarotensis U5 snRNP GTPase SNU114 XP_022630645.1 382320 D 1245769 CDS LALA0_S11e04126g 34687989 385579..386844 Unknown 1 NW_019212889.1 similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; uncharacterized protein 386844 34687989 LALA0_S11e04126g Lachancea lanzarotensis uncharacterized protein XP_022630646.1 385579 D 1245769 CDS LALA0_S11e04148g 34687990 387177..388232 Unknown 1 NW_019212889.1 highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167W ERG20 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase 388232 34687990 LALA0_S11e04148g Lachancea lanzarotensis bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase XP_022630647.1 387177 D 1245769 CDS LALA0_S11e04170g 34687991 388583..388867 Unknown 1 NW_019212889.1 highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p; ubiquinol--cytochrome-c reductase subunit 8 388867 34687991 LALA0_S11e04170g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit 8 XP_022630648.1 388583 D 1245769 CDS LALA0_S11e04192g 34687992 389456..391969 Unknown 1 NW_019212889.1 weakly similar to uniprot|P36003 Saccharomyces cerevisiae YKL171W NNK1 Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm; protein kinase NNK1 391969 34687992 LALA0_S11e04192g Lachancea lanzarotensis protein kinase NNK1 XP_022630649.1 389456 D 1245769 CDS LALA0_S11e04214g 34687993 392212..392628 Unknown 1 NW_019212889.1 highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; mitochondrial 54S ribosomal protein uL14m 392628 34687993 LALA0_S11e04214g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL14m XP_022630650.1 392212 D 1245769 CDS LALA0_S11e04236g 34687994 complement(392795..394918) Unknown 1 NW_019212889.1 similar to uniprot|P36004 Saccharomyces cerevisiae YKL168C (ohnolog of YJL165C) KKQ8 Putative serine/threonine protein kinase with unknown cellular role; uncharacterized protein 394918 34687994 LALA0_S11e04236g Lachancea lanzarotensis uncharacterized protein XP_022630651.1 392795 R 1245769 CDS LALA0_S11e04258g 34687995 complement(395235..397103) Unknown 1 NW_019212889.1 similar to Lachancea thermotolerans KLTH0F05082g hypothetical protein; uncharacterized protein 397103 34687995 LALA0_S11e04258g Lachancea lanzarotensis uncharacterized protein XP_022630652.1 395235 R 1245769 CDS LALA0_S11e04280g 34687996 complement(397513..397908) Unknown 1 NW_019212889.1 similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation; mitochondrial 54S ribosomal protein mL61 397908 34687996 LALA0_S11e04280g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL61 XP_022630653.1 397513 R 1245769 CDS LALA0_S11e04302g 34687997 complement(398366..399523) Unknown 1 NW_019212889.1 similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C (ohnolog of YJL164C) TPK3 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; cAMP-dependent protein kinase catalytic subunit TPK3 399523 34687997 LALA0_S11e04302g Lachancea lanzarotensis cAMP-dependent protein kinase catalytic subunit TPK3 XP_022630654.1 398366 R 1245769 CDS LALA0_S11e04324g 34687998 complement(400136..401959) Unknown 1 NW_019212889.1 similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C Putative protein of unknown function; uncharacterized protein 401959 34687998 LALA0_S11e04324g Lachancea lanzarotensis uncharacterized protein XP_022630655.1 400136 R 1245769 CDS LALA0_S11e04346g 34687999 complement(402370..405138) Unknown 1 NW_019212889.1 highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; mannose-ethanolamine phosphotransferase MCD4 405138 34687999 LALA0_S11e04346g Lachancea lanzarotensis mannose-ethanolamine phosphotransferase MCD4 XP_022630656.1 402370 R 1245769 CDS LALA0_S11e04368g 34688000 complement(405333..407126) Unknown 1 NW_019212889.1 weakly similar to uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein; uncharacterized protein 407126 34688000 LALA0_S11e04368g Lachancea lanzarotensis uncharacterized protein XP_022630657.1 405333 R 1245769 CDS LALA0_S11e04456g 34688003 408506..408919 Unknown 1 NW_019212889.1 weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161W FMP33 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 408919 34688003 LALA0_S11e04456g Lachancea lanzarotensis uncharacterized protein XP_022630658.1 408506 D 1245769 CDS LALA0_S11e04478g 34688004 complement(409215..410258) Unknown 1 NW_019212889.1 similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; uncharacterized protein 410258 34688004 LALA0_S11e04478g Lachancea lanzarotensis uncharacterized protein XP_022630659.1 409215 R 1245769 CDS LALA0_S11e04500g 34688005 411809..412999 Unknown 1 NW_019212889.1 similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; uncharacterized protein 412999 34688005 LALA0_S11e04500g Lachancea lanzarotensis uncharacterized protein XP_022630660.1 411809 D 1245769 CDS LALA0_S11e04544g 34688007 413918..414787 Unknown 1 NW_019212889.1 similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones; acylglycerone-phosphate reductase 414787 34688007 LALA0_S11e04544g Lachancea lanzarotensis acylglycerone-phosphate reductase XP_022630661.1 413918 D 1245769 CDS LALA0_S11e04566g 34688008 complement(415037..415873) Unknown 1 NW_019212889.1 similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; uncharacterized protein 415873 34688008 LALA0_S11e04566g Lachancea lanzarotensis uncharacterized protein XP_022630662.1 415037 R 1245769 CDS LALA0_S11e04588g 34688009 complement(417982..421239) Unknown 1 NW_019212889.1 similar to uniprot|C5DKK5 Lachancea thermotolerans KLTH0F05478g hypothetical protein; cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 421239 34688009 LALA0_S11e04588g Lachancea lanzarotensis cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 XP_022630663.1 417982 R 1245769 CDS LALA0_S11e04610g 34688010 complement(422275..424317) Unknown 1 NW_019212889.1 similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; uncharacterized protein 424317 34688010 LALA0_S11e04610g Lachancea lanzarotensis uncharacterized protein XP_022630664.1 422275 R 1245769 CDS LALA0_S11e04632g 34688011 complement(join(424598..425920,426045..426068)) Unknown 1 NW_019212889.1 highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2,6-bisphosphatase, required for glucose metabolism; fructose-2,6-bisphosphatase 426068 34688011 LALA0_S11e04632g Lachancea lanzarotensis fructose-2,6-bisphosphatase XP_022630665.1 424598 R 1245769 CDS LALA0_S11e04654g 34688012 complement(426287..428857) Unknown 1 NW_019212889.1 similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; retromer subunit VPS35 428857 34688012 LALA0_S11e04654g Lachancea lanzarotensis retromer subunit VPS35 XP_022630666.1 426287 R 1245769 CDS LALA0_S11e04676g 34688013 429994..431037 Unknown 1 NW_019212889.1 similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; cytochrome-c peroxidase 431037 34688013 LALA0_S11e04676g Lachancea lanzarotensis cytochrome-c peroxidase XP_022630667.1 429994 D 1245769 CDS LALA0_S11e04698g 34688014 431404..431988 Unknown 1 NW_019212889.1 similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C PAM17 Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex; uncharacterized protein 431988 34688014 LALA0_S11e04698g Lachancea lanzarotensis uncharacterized protein XP_022630668.1 431404 D 1245769 CDS LALA0_S11e04720g 34688015 complement(432340..432708) Unknown 1 NW_019212889.1 similar to uniprot|P14359 Saccharomyces cerevisiae YJL151C SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; uncharacterized protein 432708 34688015 LALA0_S11e04720g Lachancea lanzarotensis uncharacterized protein XP_022630669.1 432340 R 1245769 CDS LALA0_S11e04742g 34688016 433973..435781 Unknown 1 NW_019212889.1 similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W DAS1 Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; SCF ubiquitin ligase complex subunit DAS1 435781 34688016 LALA0_S11e04742g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit DAS1 XP_022630670.1 433973 D 1245769 CDS LALA0_S11e04764g 34688017 complement(435890..438274) Unknown 1 NW_019212889.1 weakly similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W OAF3 Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 438274 34688017 LALA0_S11e04764g Lachancea lanzarotensis uncharacterized protein XP_022630671.1 435890 R 1245769 CDS LALA0_S11e04786g 34688018 438535..439932 Unknown 1 NW_019212889.1 weakly similar to uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability; rRNA-processing protein LAS1 439932 34688018 LALA0_S11e04786g Lachancea lanzarotensis rRNA-processing protein LAS1 XP_022630672.1 438535 D 1245769 CDS LALA0_S11e04808g 34688019 441506..441991 Unknown 1 NW_019212889.1 some similarities with uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5; DNA-directed RNA polymerase I subunit RPA34 441991 34688019 LALA0_S11e04808g Lachancea lanzarotensis DNA-directed RNA polymerase I subunit RPA34 XP_022630673.1 441506 D 1245769 CDS LALA0_S11e04830g 34688020 complement(442374..443210) Unknown 1 NW_019212889.1 similar to uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit, involved in RNA polymerase II transcription initiation; transcription factor TFIIE subunit TFA2 443210 34688020 LALA0_S11e04830g Lachancea lanzarotensis transcription factor TFIIE subunit TFA2 XP_022630674.1 442374 R 1245769 CDS LALA0_S11e04852g 34688021 complement(443819..444901) Unknown 1 NW_019212889.1 weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene; uncharacterized protein 444901 34688021 LALA0_S11e04852g Lachancea lanzarotensis uncharacterized protein XP_022630675.1 443819 R 1245769 CDS LALA0_S11e04874g 34688022 445974..447107 Unknown 1 NW_019212889.1 weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation; uncharacterized protein 447107 34688022 LALA0_S11e04874g Lachancea lanzarotensis uncharacterized protein XP_022630676.1 445974 D 1245769 CDS LALA0_S11e04896g 34688023 447497..448354 Unknown 1 NW_019212889.1 similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; uncharacterized protein 448354 34688023 LALA0_S11e04896g Lachancea lanzarotensis uncharacterized protein XP_022630677.1 447497 D 1245769 CDS LALA0_S11e04918g 34688024 complement(448447..449601) Unknown 1 NW_019212889.1 highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; biotin synthase 449601 34688024 LALA0_S11e04918g Lachancea lanzarotensis biotin synthase XP_022630678.1 448447 R 1245769 CDS LALA0_S11e04940g 34688025 451047..451403 Unknown 1 NW_019212889.1 similar to uniprot|C5DKM6 Lachancea thermotolerans KLTH0F05940g hypothetical protein; uncharacterized protein 451403 34688025 LALA0_S11e04940g Lachancea lanzarotensis uncharacterized protein XP_022630679.1 451047 D 1245769 CDS LALA0_S11e04962g 34688026 451910..452386 Unknown 1 NW_019212889.1 highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex; protein transporter TIM17 452386 34688026 LALA0_S11e04962g Lachancea lanzarotensis protein transporter TIM17 XP_022630680.1 451910 D 1245769 CDS LALA0_S11e04984g 34688027 complement(452662..454692) Unknown 1 NW_019212889.1 similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose; serine/threonine protein kinase YAK1 454692 34688027 LALA0_S11e04984g Lachancea lanzarotensis serine/threonine protein kinase YAK1 XP_022630681.1 452662 R 1245769 CDS LALA0_S11e05006g 34688028 456269..456862 Unknown 1 NW_019212889.1 similar to uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; DNA-directed RNA polymerase II subunit RPB4 456862 34688028 LALA0_S11e05006g Lachancea lanzarotensis DNA-directed RNA polymerase II subunit RPB4 XP_022630682.1 456269 D 1245769 CDS LALA0_S11e05028g 34688029 complement(456911..458188) Unknown 1 NW_019212889.1 similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W (ohnolog of YJL139C) KTR2 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; uncharacterized protein 458188 34688029 LALA0_S11e05028g Lachancea lanzarotensis uncharacterized protein XP_022630683.1 456911 R 1245769 CDS LALA0_S11e05050g 34688030 complement(458498..459310) Unknown 1 NW_019212889.1 similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; uncharacterized protein 459310 34688030 LALA0_S11e05050g Lachancea lanzarotensis uncharacterized protein XP_022630684.1 458498 R 1245769 CDS LALA0_S11e05072g 34688031 complement(459724..460914) Unknown 1 NW_019212889.1 highly similar to uniprot|P10081 Saccharomyces cerevisiae YJL138C (ohnolog of YKR059W) TIF2 Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; uncharacterized protein 460914 34688031 LALA0_S11e05072g Lachancea lanzarotensis uncharacterized protein XP_022630685.1 459724 R 1245769 CDS LALA0_S11e05094g 34688032 complement(461500..462690) Unknown 1 NW_019212889.1 weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C (ohnolog of YKR058W) GLG2 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; uncharacterized protein 462690 34688032 LALA0_S11e05094g Lachancea lanzarotensis uncharacterized protein XP_022630686.1 461500 R 1245769 CDS LALA0_S11e05116g 34688033 complement(join(463078..463317,463673..463696)) Unknown 1 NW_019212889.1 highly similar to uniprot|P05760 Saccharomyces cerevisiae YJL136C (ohnolog of YKR057W) RPS21B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein; 40S ribosomal protein eS21 463696 34688033 LALA0_S11e05116g Lachancea lanzarotensis 40S ribosomal protein eS21 XP_022630687.1 463078 R 1245769 CDS LALA0_S11e05138g 34688034 complement(464310..466100) Unknown 1 NW_019212889.1 similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; tRNA (uracil(54)-C(5))-methyltransferase 466100 34688034 LALA0_S11e05138g Lachancea lanzarotensis tRNA (uracil(54)-C(5))-methyltransferase XP_022630688.1 464310 R 1245769 CDS LALA0_S11e05160g 34688035 complement(466922..467632) Unknown 1 NW_019212889.1 similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity; Rho family GTPase RHO4 467632 34688035 LALA0_S11e05160g Lachancea lanzarotensis Rho family GTPase RHO4 XP_022630689.1 466922 R 1245769 CDS LALA0_S11e05182g 34688036 468011..480319 Unknown 1 NW_019212889.1 similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; dynein heavy chain 480319 34688036 LALA0_S11e05182g Lachancea lanzarotensis dynein heavy chain XP_022630690.1 468011 D 1245769 CDS LALA0_S11e05204g 34688037 480585..481811 Unknown 1 NW_019212889.1 similar to uniprot|P47013 Saccharomyces cerevisiae YJL134W (ohnolog of YKR053C) LCB3 Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; uncharacterized protein 481811 34688037 LALA0_S11e05204g Lachancea lanzarotensis uncharacterized protein XP_022630691.1 480585 D 1245769 CDS LALA0_S11e05226g 34688038 483749..484681 Unknown 1 NW_019212889.1 similar to uniprot|P10566 Saccharomyces cerevisiae YJL133W (ohnolog of YKR052C) MRS3 Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations; uncharacterized protein 484681 34688038 LALA0_S11e05226g Lachancea lanzarotensis uncharacterized protein XP_022630692.1 483749 D 1245769 CDS LALA0_S11e05248g 34688039 complement(484934..486184) Unknown 1 NW_019212889.1 similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Putative protein of unknown function; uncharacterized protein 486184 34688039 LALA0_S11e05248g Lachancea lanzarotensis uncharacterized protein XP_022630693.1 484934 R 1245769 CDS LALA0_S11e05270g 34688040 488018..490216 Unknown 1 NW_019212889.1 similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene; uncharacterized protein 490216 34688040 LALA0_S11e05270g Lachancea lanzarotensis uncharacterized protein XP_022630694.1 488018 D 1245769 CDS LALA0_S11e05292g 34688041 complement(490315..491427) Unknown 1 NW_019212889.1 similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C AIM23 Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss; uncharacterized protein 491427 34688041 LALA0_S11e05292g Lachancea lanzarotensis uncharacterized protein XP_022630695.1 490315 R 1245769 CDS LALA0_S11e05314g 34688042 complement(491772..498428) Unknown 1 NW_019212889.1 highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase 498428 34688042 LALA0_S11e05314g Lachancea lanzarotensis bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase XP_022630696.1 491772 R 1245769 CDS LALA0_S11e05336g 34688043 complement(499782..503291) Unknown 1 NW_019212889.1 some similarities with uniprot|P12685 Saccharomyces cerevisiae YJL129C (ohnolog of YKR050W) TRK1 Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; uncharacterized protein 503291 34688043 LALA0_S11e05336g Lachancea lanzarotensis uncharacterized protein XP_022630697.1 499782 R 1245769 CDS LALA0_S11e05358g 34688044 complement(503751..505679) Unknown 1 NW_019212889.1 similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition; mitogen-activated protein kinase kinase PBS2 505679 34688044 LALA0_S11e05358g Lachancea lanzarotensis mitogen-activated protein kinase kinase PBS2 XP_022630698.1 503751 R 1245769 CDS LALA0_S11e05380g 34688045 complement(506309..506461) Unknown 1 NW_019212889.1 similar to uniprot|Q3E828 Saccharomyces cerevisiae YJL127C-B Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii; uncharacterized protein 506461 34688045 LALA0_S11e05380g Lachancea lanzarotensis uncharacterized protein XP_022630699.1 506309 R 1245769 CDS LALA0_S11e05402g 34688046 507017..508975 Unknown 1 NW_019212889.1 similar to uniprot|C5DGT5 Lachancea thermotolerans KLTH0D08118g hypothetical protein; uncharacterized protein 508975 34688046 LALA0_S11e05402g Lachancea lanzarotensis uncharacterized protein XP_022630700.1 507017 D 1245769 CDS LALA0_S11e05424g 34688047 complement(509011..510672) Unknown 1 NW_019212889.1 similar to uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box; uncharacterized protein 510672 34688047 LALA0_S11e05424g Lachancea lanzarotensis uncharacterized protein XP_022630701.1 509011 R 1245769 CDS LALA0_S12e00100g 34688048 complement(join(2547..2651,2654..3124)) Unknown 1 NW_019212890.1 some similarities with uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; 3124 34688048 LALA0_S12e00100g Lachancea lanzarotensis 2547 R 1245769 CDS LALA0_S12e00122g 34688049 4325..4942 Unknown 1 NW_019212890.1 some similarities with uniprot|C5DFQ0 Lachancea thermotolerans KLTH0D16940g hypothetical protein; uncharacterized protein 4942 34688049 LALA0_S12e00122g Lachancea lanzarotensis uncharacterized protein XP_022630702.1 4325 D 1245769 CDS LALA0_S12e00144g 34688050 complement(6999..7607) Unknown 1 NW_019212890.1 weakly similar to uniprot|C5DNS2 Lachancea thermotolerans KLTH0G19382g hypothetical protein; uncharacterized protein 7607 34688050 LALA0_S12e00144g Lachancea lanzarotensis uncharacterized protein XP_022630703.1 6999 R 1245769 CDS LALA0_S12e00166g 34688051 complement(9530..10111) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C HSP31 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; uncharacterized protein 10111 34688051 LALA0_S12e00166g Lachancea lanzarotensis uncharacterized protein XP_022630704.1 9530 R 1245769 CDS LALA0_S12e00188g 34688052 complement(11336..13033) Unknown 1 NW_019212890.1 similar to uniprot|C5DDC7 Lachancea thermotolerans KLTH0B10164g hypothetical protein; uncharacterized protein 13033 34688052 LALA0_S12e00188g Lachancea lanzarotensis uncharacterized protein XP_022630705.1 11336 R 1245769 CDS LALA0_S12e00210g 34688053 18135..19865 Unknown 1 NW_019212890.1 some similarities with uniprot|Q7LHD1 Saccharomyces cerevisiae YDR134C YDR134C Putative uncharacterized cell wall protein; uncharacterized protein 19865 34688053 LALA0_S12e00210g Lachancea lanzarotensis uncharacterized protein XP_022630706.1 18135 D 1245769 CDS LALA0_S12e00232g 34688054 complement(21055..22806) Unknown 1 NW_019212890.1 similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p; uncharacterized protein 22806 34688054 LALA0_S12e00232g Lachancea lanzarotensis uncharacterized protein XP_022630707.1 21055 R 1245769 CDS LALA0_S12e00254g 34688055 25041..26051 Unknown 1 NW_019212890.1 similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C (ohnolog of YPL273W) MHT1 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; uncharacterized protein 26051 34688055 LALA0_S12e00254g Lachancea lanzarotensis uncharacterized protein XP_022630708.1 25041 D 1245769 CDS LALA0_S12e00276g 34688056 29007..29930 Unknown 1 NW_019212890.1 similar to uniprot|C5DKP4 Lachancea thermotolerans KLTH0F06380g hypothetical protein; uncharacterized protein 29930 34688056 LALA0_S12e00276g Lachancea lanzarotensis uncharacterized protein XP_022630709.1 29007 D 1245769 CDS LALA0_S12e00298g 34688057 complement(30473..31771) Unknown 1 NW_019212890.1 similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein; uncharacterized protein 31771 34688057 LALA0_S12e00298g Lachancea lanzarotensis uncharacterized protein XP_022630710.1 30473 R 1245769 CDS LALA0_S12e00320g 34688058 complement(32458..33216) Unknown 1 NW_019212890.1 weakly similar to uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; uncharacterized protein 33216 34688058 LALA0_S12e00320g Lachancea lanzarotensis uncharacterized protein XP_022630711.1 32458 R 1245769 CDS LALA0_S12e00342g 34688059 35329..37032 Unknown 1 NW_019212890.1 similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively; beta-fructofuranosidase SUC2 37032 34688059 LALA0_S12e00342g Lachancea lanzarotensis beta-fructofuranosidase SUC2 XP_022630712.1 35329 D 1245769 CDS LALA0_S12e00364g 34688060 complement(38241..39893) Unknown 1 NW_019212890.1 similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane; uncharacterized protein 39893 34688060 LALA0_S12e00364g Lachancea lanzarotensis uncharacterized protein XP_022630713.1 38241 R 1245769 CDS LALA0_S12e00386g 34688061 complement(42720..43436) Unknown 1 NW_019212890.1 highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C HSP31 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; uncharacterized protein 43436 34688061 LALA0_S12e00386g Lachancea lanzarotensis uncharacterized protein XP_022630714.1 42720 R 1245769 CDS LALA0_S12e00474g 34688063 46735..48096 Unknown 1 NW_019212890.1 similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; histone chaperone NAP1 48096 34688063 LALA0_S12e00474g Lachancea lanzarotensis histone chaperone NAP1 XP_022630715.1 46735 D 1245769 CDS LALA0_S12e00496g 34688064 48696..49667 Unknown 1 NW_019212890.1 weakly similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange; uncharacterized protein 49667 34688064 LALA0_S12e00496g Lachancea lanzarotensis uncharacterized protein XP_022630716.1 48696 D 1245769 CDS LALA0_S12e00518g 34688065 join(50756..50789,50869..51458) Unknown 1 NW_019212890.1 weakly similar to uniprot|P36138 Saccharomyces cerevisiae YKR045C Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; uncharacterized protein 51458 34688065 LALA0_S12e00518g Lachancea lanzarotensis uncharacterized protein XP_022630717.1 50756 D 1245769 CDS LALA0_S12e00540g 34688066 51859..52869 Unknown 1 NW_019212890.1 similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; uncharacterized protein 52869 34688066 LALA0_S12e00540g Lachancea lanzarotensis uncharacterized protein XP_022630718.1 51859 D 1245769 CDS LALA0_S12e00562g 34688067 complement(52926..54182) Unknown 1 NW_019212890.1 similar to uniprot|P36137 Saccharomyces cerevisiae YKR044W UIP5 Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; uncharacterized protein 54182 34688067 LALA0_S12e00562g Lachancea lanzarotensis uncharacterized protein XP_022630719.1 52926 R 1245769 CDS LALA0_S12e00584g 34688068 56072..56887 Unknown 1 NW_019212890.1 highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus; sedoheptulose-bisphosphatase 56887 34688068 LALA0_S12e00584g Lachancea lanzarotensis sedoheptulose-bisphosphatase XP_022630720.1 56072 D 1245769 CDS LALA0_S12e00606g 34688069 57013..57951 Unknown 1 NW_019212890.1 weakly similar to uniprot|Q05947 Saccharomyces cerevisiae YLR224W F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene; uncharacterized protein 57951 34688069 LALA0_S12e00606g Lachancea lanzarotensis uncharacterized protein XP_022630721.1 57013 D 1245769 CDS LALA0_S12e00628g 34688070 complement(58484..59530) Unknown 1 NW_019212890.1 similar to uniprot|P46955 Saccharomyces cerevisiae YJL116C (ohnolog of YKR042W) NCA3 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; SUN family protein UTH1 59530 34688070 LALA0_S12e00628g Lachancea lanzarotensis SUN family protein UTH1 XP_022630722.1 58484 R 1245769 CDS LALA0_S12e00672g 34688072 64994..66187 Unknown 1 NW_019212890.1 similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 66187 34688072 LALA0_S12e00672g Lachancea lanzarotensis uncharacterized protein XP_022630723.1 64994 D 1245769 CDS LALA0_S12e00694g 34688073 66522..67439 Unknown 1 NW_019212890.1 similar to uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition; nucleosome assembly factor ASF1 67439 34688073 LALA0_S12e00694g Lachancea lanzarotensis nucleosome assembly factor ASF1 XP_022630724.1 66522 D 1245769 CDS LALA0_S12e00716g 34688074 complement(67492..68349) Unknown 1 NW_019212890.1 weakly similar to uniprot|P36134 Saccharomyces cerevisiae YKR041W Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking; uncharacterized protein 68349 34688074 LALA0_S12e00716g Lachancea lanzarotensis uncharacterized protein XP_022630725.1 67492 R 1245769 CDS LALA0_S12e00738g 34688075 68868..71333 Unknown 1 NW_019212890.1 similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p; serine/threonine/tyrosine protein kinase MPS1 71333 34688075 LALA0_S12e00738g Lachancea lanzarotensis serine/threonine/tyrosine protein kinase MPS1 XP_022630726.1 68868 D 1245769 CDS LALA0_S12e00760g 34688076 complement(join(71508..72661,72783..72804)) Unknown 1 NW_019212890.1 highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; actin-related protein 2 72804 34688076 LALA0_S12e00760g Lachancea lanzarotensis actin-related protein 2 XP_022630727.1 71508 R 1245769 CDS LALA0_S12e00782g 34688077 complement(73072..74181) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene; uncharacterized protein 74181 34688077 LALA0_S12e00782g Lachancea lanzarotensis uncharacterized protein XP_022630728.1 73072 R 1245769 CDS LALA0_S12e00804g 34688078 complement(74342..75736) Unknown 1 NW_019212890.1 similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport; uncharacterized protein 75736 34688078 LALA0_S12e00804g Lachancea lanzarotensis uncharacterized protein XP_022630729.1 74342 R 1245769 CDS LALA0_S12e00826g 34688079 76776..78188 Unknown 1 NW_019212890.1 similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS5 78188 34688079 LALA0_S12e00826g Lachancea lanzarotensis ribose phosphate diphosphokinase subunit PRS5 XP_022630730.1 76776 D 1245769 CDS LALA0_S12e00848g 34688080 complement(78323..80068) Unknown 1 NW_019212890.1 similar to uniprot|Q12100 Saccharomyces cerevisiae YDL025C RTK1 Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; uncharacterized protein 80068 34688080 LALA0_S12e00848g Lachancea lanzarotensis uncharacterized protein XP_022630731.1 78323 R 1245769 CDS LALA0_S12e00870g 34688081 complement(80455..82527) Unknown 1 NW_019212890.1 similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C MAM3 Protein required for normal mitochondrial morphology, has similarity to hemolysins; uncharacterized protein 82527 34688081 LALA0_S12e00870g Lachancea lanzarotensis uncharacterized protein XP_022630732.1 80455 R 1245769 CDS LALA0_S12e00892g 34688082 complement(join(83720..85480,85482..86102)) Unknown 1 NW_019212890.1 putative transposase of a hAT-like DNA transposon, degenerate;putative transposase of a hAT-like DNA transposon, degenerate; 86102 34688082 LALA0_S12e00892g Lachancea lanzarotensis 83720 R 1245769 CDS LALA0_S12e00958g 34688083 87718..88884 Unknown 1 NW_019212890.1 highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W (ohnolog of YOL059W) GPD1 NAD-dependentglycerol-3-phosphate dehydrogenase, key enzyme of glycerolsynthesis, essential for growth under osmotic stress;expression regulated by high-osmolarity glycerol responsepathway; homolog of Gpd2p; uncharacterized protein 88884 34688083 LALA0_S12e00958g Lachancea lanzarotensis uncharacterized protein XP_022630733.1 87718 D 1245769 CDS LALA0_S12e00980g 34688084 complement(89210..89971) Unknown 1 NW_019212890.1 weakly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; uncharacterized protein 89971 34688084 LALA0_S12e00980g Lachancea lanzarotensis uncharacterized protein XP_022630734.1 89210 R 1245769 CDS LALA0_S12e01002g 34688085 91503..93131 Unknown 1 NW_019212890.1 weakly similar to uniprot|P25297 Saccharomyces cerevisiae YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; uncharacterized protein 93131 34688085 LALA0_S12e01002g Lachancea lanzarotensis uncharacterized protein XP_022630735.1 91503 D 1245769 CDS LALA0_S12e01024g 34688086 96133..97392 Unknown 1 NW_019212890.1 highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate; argininosuccinate synthase 97392 34688086 LALA0_S12e01024g Lachancea lanzarotensis argininosuccinate synthase XP_022630736.1 96133 D 1245769 CDS LALA0_S12e01046g 34688087 98438..100585 Unknown 1 NW_019212890.1 similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers; dipeptidyl-peptidase III 100585 34688087 LALA0_S12e01046g Lachancea lanzarotensis dipeptidyl-peptidase III XP_022630737.1 98438 D 1245769 CDS LALA0_S12e01068g 34688088 100837..101739 Unknown 1 NW_019212890.1 similar to uniprot|Q12008 Saccharomyces cerevisiae YDL021W (ohnolog of YOL056W) GPM2 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event; phosphoglycerate mutase family protein GPM3 101739 34688088 LALA0_S12e01068g Lachancea lanzarotensis phosphoglycerate mutase family protein GPM3 XP_022630738.1 100837 D 1245769 CDS LALA0_S12e01090g 34688089 complement(101989..103455) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; stress-regulated transcription factor RPN4 103455 34688089 LALA0_S12e01090g Lachancea lanzarotensis stress-regulated transcription factor RPN4 XP_022630739.1 101989 R 1245769 CDS LALA0_S12e01112g 34688090 complement(104132..105862) Unknown 1 NW_019212890.1 similar to uniprot|Q6B2F0 Saccharomyces cerevisiae YOL055C THI20 Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p; trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase 105862 34688090 LALA0_S12e01112g Lachancea lanzarotensis trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase XP_022630740.1 104132 R 1245769 CDS LALA0_S12e01134g 34688091 106732..109131 Unknown 1 NW_019212890.1 some similarities with uniprot|P53379 Saccharomyces cerevisiae YDR144C (ohnolog of YLR120C) MKC7 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; uncharacterized protein 109131 34688091 LALA0_S12e01134g Lachancea lanzarotensis uncharacterized protein XP_022630741.1 106732 D 1245769 CDS LALA0_S12e01156g 34688092 complement(109299..109919) Unknown 1 NW_019212890.1 similar to uniprot|Q07923 Saccharomyces cerevisiae YLR011W LOT6 FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions; flavin-dependent quinone reductase 109919 34688092 LALA0_S12e01156g Lachancea lanzarotensis flavin-dependent quinone reductase XP_022630742.1 109299 R 1245769 CDS LALA0_S12e01178g 34688093 110774..112705 Unknown 1 NW_019212890.1 similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation; SCF ubiquitin ligase complex subunit UFO1 112705 34688093 LALA0_S12e01178g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit UFO1 XP_022630743.1 110774 D 1245769 CDS LALA0_S12e01200g 34688094 complement(112772..113698) Unknown 1 NW_019212890.1 similar to uniprot|Q04516 Saccharomyces cerevisiae YML087C (ohnolog of YML125C) AIM33 Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; uncharacterized protein 113698 34688094 LALA0_S12e01200g Lachancea lanzarotensis uncharacterized protein XP_022630744.1 112772 R 1245769 CDS LALA0_S12e01222g 34688095 complement(114085..115671) Unknown 1 NW_019212890.1 similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; D-arabinono-1,4-lactone oxidase 115671 34688095 LALA0_S12e01222g Lachancea lanzarotensis D-arabinono-1,4-lactone oxidase XP_022630745.1 114085 R 1245769 CDS LALA0_S12e01244g 34688096 complement(join(116353..117671,117998..118022)) Unknown 1 NW_019212890.1 highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C (ohnolog of YML124C) TUB1 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; uncharacterized protein 118022 34688096 LALA0_S12e01244g Lachancea lanzarotensis uncharacterized protein XP_022630746.1 116353 R 1245769 CDS LALA0_S12e01266g 34688097 complement(119214..120938) Unknown 1 NW_019212890.1 highly similar to uniprot|P25297 Saccharomyces cerevisiae YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; phosphate transporter PHO84 120938 34688097 LALA0_S12e01266g Lachancea lanzarotensis phosphate transporter PHO84 XP_022630747.1 119214 R 1245769 CDS LALA0_S12e01288g 34688098 complement(123710..124603) Unknown 1 NW_019212890.1 similar to uniprot|C5DKT0 Lachancea thermotolerans KLTH0F07238g hypothetical protein; uncharacterized protein 124603 34688098 LALA0_S12e01288g Lachancea lanzarotensis uncharacterized protein XP_022630748.1 123710 R 1245769 CDS LALA0_S12e01310g 34688099 complement(125136..126461) Unknown 1 NW_019212890.1 similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase 126461 34688099 LALA0_S12e01310g Lachancea lanzarotensis bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase XP_022630749.1 125136 R 1245769 CDS LALA0_S12e01354g 34688101 complement(127085..127714) Unknown 1 NW_019212890.1 similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; aminoacyl-tRNA hydrolase 127714 34688101 LALA0_S12e01354g Lachancea lanzarotensis aminoacyl-tRNA hydrolase XP_022630750.1 127085 R 1245769 CDS LALA0_S12e01376g 34688102 127901..128800 Unknown 1 NW_019212890.1 highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB; Rag GTPase GTR1 128800 34688102 LALA0_S12e01376g Lachancea lanzarotensis Rag GTPase GTR1 XP_022630751.1 127901 D 1245769 CDS LALA0_S12e01398g 34688103 complement(129066..130607) Unknown 1 NW_019212890.1 highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID; NADH-ubiquinone reductase (H(+)-translocating) NDI1 130607 34688103 LALA0_S12e01398g Lachancea lanzarotensis NADH-ubiquinone reductase (H(+)-translocating) NDI1 XP_022630752.1 129066 R 1245769 CDS LALA0_S12e01420g 34688104 133588..135531 Unknown 1 NW_019212890.1 highly similar to uniprot|P39987 Saccharomyces cerevisiae YEL030W (ohnolog of YJR045C) ECM10 Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; Hsp70 family ATPase SSC1 135531 34688104 LALA0_S12e01420g Lachancea lanzarotensis Hsp70 family ATPase SSC1 XP_022630753.1 133588 D 1245769 CDS LALA0_S12e01442g 34688105 join(135899..136019,136101..136402) Unknown 1 NW_019212890.1 similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP); uncharacterized protein 136402 34688105 LALA0_S12e01442g Lachancea lanzarotensis uncharacterized protein XP_022630754.1 135899 D 1245769 CDS LALA0_S12e01486g 34688107 137557..138471 Unknown 1 NW_019212890.1 similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain; phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase 138471 34688107 LALA0_S12e01486g Lachancea lanzarotensis phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase XP_022630755.1 137557 D 1245769 CDS LALA0_S12e01508g 34688108 complement(138632..139975) Unknown 1 NW_019212890.1 similar to uniprot|P38789 Saccharomyces cerevisiae YHR066W (ohnolog of YDR312W) SSF1 Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; uncharacterized protein 139975 34688108 LALA0_S12e01508g Lachancea lanzarotensis uncharacterized protein XP_022630756.1 138632 R 1245769 CDS LALA0_S12e01530g 34688109 140782..142278 Unknown 1 NW_019212890.1 highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity; RNA-dependent ATPase RRP3 142278 34688109 LALA0_S12e01530g Lachancea lanzarotensis RNA-dependent ATPase RRP3 XP_022630757.1 140782 D 1245769 CDS LALA0_S12e01552g 34688110 complement(142402..144249) Unknown 1 NW_019212890.1 similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators; TFIIH/NER complex subunit TFB1 144249 34688110 LALA0_S12e01552g Lachancea lanzarotensis TFIIH/NER complex subunit TFB1 XP_022630758.1 142402 R 1245769 CDS LALA0_S12e01574g 34688111 144710..146320 Unknown 1 NW_019212890.1 highly similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP; uncharacterized protein 146320 34688111 LALA0_S12e01574g Lachancea lanzarotensis uncharacterized protein XP_022630759.1 144710 D 1245769 CDS LALA0_S12e01596g 34688112 146736..147857 Unknown 1 NW_019212890.1 similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE; 2-dehydropantoate 2-reductase PAN5 147857 34688112 LALA0_S12e01596g Lachancea lanzarotensis 2-dehydropantoate 2-reductase PAN5 XP_022630760.1 146736 D 1245769 CDS LALA0_S12e01618g 34688113 149115..152030 Unknown 1 NW_019212890.1 weakly similar to uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint; uncharacterized protein 152030 34688113 LALA0_S12e01618g Lachancea lanzarotensis uncharacterized protein XP_022630761.1 149115 D 1245769 CDS LALA0_S12e01640g 34688114 152388..153269 Unknown 1 NW_019212890.1 similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; RNA-binding RNA processing protein RPP1 153269 34688114 LALA0_S12e01640g Lachancea lanzarotensis RNA-binding RNA processing protein RPP1 XP_022630762.1 152388 D 1245769 CDS LALA0_S12e01662g 34688115 153532..154317 Unknown 1 NW_019212890.1 weakly similar to uniprot|C5DKT5 Lachancea thermotolerans KLTH0F07348g hypothetical protein; uncharacterized protein 154317 34688115 LALA0_S12e01662g Lachancea lanzarotensis uncharacterized protein XP_022630763.1 153532 D 1245769 CDS LALA0_S12e01684g 34688116 154731..155855 Unknown 1 NW_019212890.1 weakly similar to uniprot|P38785 Saccharomyces cerevisiae YHR061C (ohnolog of YDR309C) GIC1 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; uncharacterized protein 155855 34688116 LALA0_S12e01684g Lachancea lanzarotensis uncharacterized protein XP_022630764.1 154731 D 1245769 CDS LALA0_S12e01706g 34688117 complement(156097..156606) Unknown 1 NW_019212890.1 similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER); uncharacterized protein 156606 34688117 LALA0_S12e01706g Lachancea lanzarotensis uncharacterized protein XP_022630765.1 156097 R 1245769 CDS LALA0_S12e01728g 34688118 156818..157267 Unknown 1 NW_019212890.1 similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p; uncharacterized protein 157267 34688118 LALA0_S12e01728g Lachancea lanzarotensis uncharacterized protein XP_022630766.1 156818 D 1245769 CDS LALA0_S12e01750g 34688119 complement(157358..159352) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Putative protein of unknown function; uncharacterized protein 159352 34688119 LALA0_S12e01750g Lachancea lanzarotensis uncharacterized protein XP_022630767.1 157358 R 1245769 CDS LALA0_S12e01772g 34688120 160506..162266 Unknown 1 NW_019212890.1 similar to uniprot|G8ZRR4 Torulaspora delbrueckii TDEL_0C03170 hypothetical protein; uncharacterized protein 162266 34688120 LALA0_S12e01772g Lachancea lanzarotensis uncharacterized protein XP_022630768.1 160506 D 1245769 CDS LALA0_S12e01816g 34688122 162809..164119 Unknown 1 NW_019212890.1 similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain; uncharacterized protein 164119 34688122 LALA0_S12e01816g Lachancea lanzarotensis uncharacterized protein XP_022630769.1 162809 D 1245769 CDS LALA0_S12e01838g 34688123 join(164309..164362,164416..164895) Unknown 1 NW_019212890.1 similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins; bis(5'-adenosyl)-triphosphatase 164895 34688123 LALA0_S12e01838g Lachancea lanzarotensis bis(5'-adenosyl)-triphosphatase XP_022630770.1 164309 D 1245769 CDS LALA0_S12e01860g 34688124 complement(165031..165438) Unknown 1 NW_019212890.1 similar to uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function, required for survival upon exposure to K1 killer toxin; mitochondrial 37S ribosomal protein mS41 165438 34688124 LALA0_S12e01860g Lachancea lanzarotensis mitochondrial 37S ribosomal protein mS41 XP_022630771.1 165031 R 1245769 CDS LALA0_S12e01882g 34688125 165816..166658 Unknown 1 NW_019212890.1 similar to uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p; cleavage polyadenylation factor subunit FIP1 166658 34688125 LALA0_S12e01882g Lachancea lanzarotensis cleavage polyadenylation factor subunit FIP1 XP_022630772.1 165816 D 1245769 CDS LALA0_S12e01904g 34688126 complement(166742..170779) Unknown 1 NW_019212890.1 weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Involved in bud-site selection and required for the axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; required for the formation of a double septin ring, and generally for the organization of septin structures; potential Cdc28p substrate; uncharacterized protein 170779 34688126 LALA0_S12e01904g Lachancea lanzarotensis uncharacterized protein XP_022630773.1 166742 R 1245769 CDS LALA0_S12e01948g 34688128 172326..175583 Unknown 1 NW_019212890.1 similar to uniprot|Q12221 Saccharomyces cerevisiae YPR042C (ohnolog of YJR091C) PUF2 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; uncharacterized protein 175583 34688128 LALA0_S12e01948g Lachancea lanzarotensis uncharacterized protein XP_022630774.1 172326 D 1245769 CDS LALA0_S12e01970g 34688129 176164..179532 Unknown 1 NW_019212890.1 similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification; SCF ubiquitin ligase complex subunit GRR1 179532 34688129 LALA0_S12e01970g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit GRR1 XP_022630775.1 176164 D 1245769 CDS LALA0_S12e01992g 34688130 complement(179589..182171) Unknown 1 NW_019212890.1 weakly similar to uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; survivin 182171 34688130 LALA0_S12e01992g Lachancea lanzarotensis survivin XP_022630776.1 179589 R 1245769 CDS LALA0_S12e02014g 34688131 complement(183080..184294) Unknown 1 NW_019212890.1 highly similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2; translation initiation factor eIF5 184294 34688131 LALA0_S12e02014g Lachancea lanzarotensis translation initiation factor eIF5 XP_022630777.1 183080 R 1245769 CDS LALA0_S12e02036g 34688132 185668..186522 Unknown 1 NW_019212890.1 similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C EMC2 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; uncharacterized protein 186522 34688132 LALA0_S12e02036g Lachancea lanzarotensis uncharacterized protein XP_022630778.1 185668 D 1245769 CDS LALA0_S12e02058g 34688133 complement(186625..187710) Unknown 1 NW_019212890.1 similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway; uncharacterized protein 187710 34688133 LALA0_S12e02058g Lachancea lanzarotensis uncharacterized protein XP_022630779.1 186625 R 1245769 CDS LALA0_S12e02080g 34688134 188072..188674 Unknown 1 NW_019212890.1 similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER; flavin-linked sulfhydryl oxidase 188674 34688134 LALA0_S12e02080g Lachancea lanzarotensis flavin-linked sulfhydryl oxidase XP_022630780.1 188072 D 1245769 CDS LALA0_S12e02102g 34688135 complement(188808..189095) Unknown 1 NW_019212890.1 similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; uncharacterized protein 189095 34688135 LALA0_S12e02102g Lachancea lanzarotensis uncharacterized protein XP_022630781.1 188808 R 1245769 CDS LALA0_S12e02124g 34688136 190483..190797 Unknown 1 NW_019212890.1 similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 190797 34688136 LALA0_S12e02124g Lachancea lanzarotensis uncharacterized protein XP_022630782.1 190483 D 1245769 CDS LALA0_S12e02146g 34688137 complement(190990..191115) Unknown 1 NW_019212890.1 similar to uniprot|I6ND86 Eremothecium cymbalariae Ecym_5263 hypothetical protein; uncharacterized protein 191115 34688137 LALA0_S12e02146g Lachancea lanzarotensis uncharacterized protein XP_022630783.1 190990 R 1245769 CDS LALA0_S12e02168g 34688138 complement(191802..193109) Unknown 1 NW_019212890.1 similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome; uncharacterized protein 193109 34688138 LALA0_S12e02168g Lachancea lanzarotensis uncharacterized protein XP_022630784.1 191802 R 1245769 CDS LALA0_S12e02190g 34688139 193780..194610 Unknown 1 NW_019212890.1 weakly similar to uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate; uncharacterized protein 194610 34688139 LALA0_S12e02190g Lachancea lanzarotensis uncharacterized protein XP_022630785.1 193780 D 1245769 CDS LALA0_S12e02212g 34688140 complement(194702..196099) Unknown 1 NW_019212890.1 similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; H(+)-transporting V1 sector ATPase subunit H 196099 34688140 LALA0_S12e02212g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit H XP_022630786.1 194702 R 1245769 CDS LALA0_S12e02234g 34688141 complement(197517..198635) Unknown 1 NW_019212890.1 highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; glutamate--ammonia ligase 198635 34688141 LALA0_S12e02234g Lachancea lanzarotensis glutamate--ammonia ligase XP_022630787.1 197517 R 1245769 CDS LALA0_S12e02256g 34688142 202197..203861 Unknown 1 NW_019212890.1 some similarities with uniprot|P36151 Saccharomyces cerevisiae YKR070W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 203861 34688142 LALA0_S12e02256g Lachancea lanzarotensis uncharacterized protein XP_022630788.1 202197 D 1245769 CDS LALA0_S12e02278g 34688143 complement(204354..205385) Unknown 1 NW_019212890.1 similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; uncharacterized protein 205385 34688143 LALA0_S12e02278g Lachancea lanzarotensis uncharacterized protein XP_022630789.1 204354 R 1245769 CDS LALA0_S12e02300g 34688144 complement(205662..207947) Unknown 1 NW_019212890.1 similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion; uncharacterized protein 207947 34688144 LALA0_S12e02300g Lachancea lanzarotensis uncharacterized protein XP_022630790.1 205662 R 1245769 CDS LALA0_S12e02322g 34688145 complement(209100..210782) Unknown 1 NW_019212890.1 highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein; chaperonin-containing T-complex alpha subunit TCP1 210782 34688145 LALA0_S12e02322g Lachancea lanzarotensis chaperonin-containing T-complex alpha subunit TCP1 XP_022630791.1 209100 R 1245769 CDS LALA0_S12e02344g 34688146 complement(211469..212044) Unknown 1 NW_019212890.1 highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins; Rho family GTPase CDC42 212044 34688146 LALA0_S12e02344g Lachancea lanzarotensis Rho family GTPase CDC42 XP_022630792.1 211469 R 1245769 CDS LALA0_S12e02366g 34688147 complement(212807..215008) Unknown 1 NW_019212890.1 similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B catalytic subunit epsilon 215008 34688147 LALA0_S12e02366g Lachancea lanzarotensis translation initiation factor eIF2B catalytic subunit epsilon XP_022630793.1 212807 R 1245769 CDS LALA0_S12e02410g 34688149 complement(215984..216220) Unknown 1 NW_019212890.1 some similarities with uniprot|C5DD14 Lachancea thermotolerans KLTH0B07502g hypothetical protein; cysteine-rich palmitoylated domain-containing protein CPP2 216220 34688149 LALA0_S12e02410g Lachancea lanzarotensis cysteine-rich palmitoylated domain-containing protein CPP2 XP_022630794.1 215984 R 1245769 CDS LALA0_S12e02432g 34688150 complement(216803..218929) Unknown 1 NW_019212890.1 similar to uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; 1-phosphatidylinositol-4-phosphate 5-kinase 218929 34688150 LALA0_S12e02432g Lachancea lanzarotensis 1-phosphatidylinositol-4-phosphate 5-kinase XP_022630795.1 216803 R 1245769 CDS LALA0_S12e02454g 34688151 221547..222548 Unknown 1 NW_019212890.1 similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Putative protein of unknown function; deletion mutant has no detectable phenotype; uncharacterized protein 222548 34688151 LALA0_S12e02454g Lachancea lanzarotensis uncharacterized protein XP_022630796.1 221547 D 1245769 CDS LALA0_S12e02476g 34688152 223695..226967 Unknown 1 NW_019212890.1 similar to uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; uncharacterized protein 226967 34688152 LALA0_S12e02476g Lachancea lanzarotensis uncharacterized protein XP_022630797.1 223695 D 1245769 CDS LALA0_S12e02498g 34688153 complement(227077..228465) Unknown 1 NW_019212890.1 similar to uniprot|Q05979 Saccharomyces cerevisiae YLR231C BNA5 Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; kynureninase 228465 34688153 LALA0_S12e02498g Lachancea lanzarotensis kynureninase XP_022630798.1 227077 R 1245769 CDS LALA0_S12e02520g 34688154 complement(229084..230661) Unknown 1 NW_019212890.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; uncharacterized protein 230661 34688154 LALA0_S12e02520g Lachancea lanzarotensis uncharacterized protein XP_022630799.1 229084 R 1245769 CDS LALA0_S12e02542g 34688155 232640..234895 Unknown 1 NW_019212890.1 weakly similar to uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p; DNA-binding transcriptional regulator UME6 234895 34688155 LALA0_S12e02542g Lachancea lanzarotensis DNA-binding transcriptional regulator UME6 XP_022630800.1 232640 D 1245769 CDS LALA0_S12e02564g 34688156 complement(235571..238093) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q03466 Saccharomyces cerevisiae YDR206W (ohnolog of YLR233C) EBS1 Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; uncharacterized protein 238093 34688156 LALA0_S12e02564g Lachancea lanzarotensis uncharacterized protein XP_022630801.1 235571 R 1245769 CDS LALA0_S12e02586g 34688157 238488..240377 Unknown 1 NW_019212890.1 similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination; DNA topoisomerase 3 240377 34688157 LALA0_S12e02586g Lachancea lanzarotensis DNA topoisomerase 3 XP_022630802.1 238488 D 1245769 CDS LALA0_S12e02608g 34688158 complement(240458..242527) Unknown 1 NW_019212890.1 similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; metal cation transporter MSC2 242527 34688158 LALA0_S12e02608g Lachancea lanzarotensis metal cation transporter MSC2 XP_022630803.1 240458 R 1245769 CDS LALA0_S12e02630g 34688159 244041..245342 Unknown 1 NW_019212890.1 highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence; adenylosuccinate synthase 245342 34688159 LALA0_S12e02630g Lachancea lanzarotensis adenylosuccinate synthase XP_022630804.1 244041 D 1245769 CDS LALA0_S12e02652g 34688160 complement(245436..247085) Unknown 1 NW_019212890.1 similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase 247085 34688160 LALA0_S12e02652g Lachancea lanzarotensis dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase XP_022630805.1 245436 R 1245769 CDS LALA0_S12e02674g 34688161 247883..248809 Unknown 1 NW_019212890.1 similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; 4-nitrophenylphosphatase 248809 34688161 LALA0_S12e02674g Lachancea lanzarotensis 4-nitrophenylphosphatase XP_022630806.1 247883 D 1245769 CDS LALA0_S12e02696g 34688162 249010..250656 Unknown 1 NW_019212890.1 similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); ssDNA-dependent ATPase MGS1 250656 34688162 LALA0_S12e02696g Lachancea lanzarotensis ssDNA-dependent ATPase MGS1 XP_022630807.1 249010 D 1245769 CDS LALA0_S12e02718g 34688163 complement(250840..251256) Unknown 1 NW_019212890.1 similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; uncharacterized protein 251256 34688163 LALA0_S12e02718g Lachancea lanzarotensis uncharacterized protein XP_022630808.1 250840 R 1245769 CDS LALA0_S12e02740g 34688164 252383..253318 Unknown 1 NW_019212890.1 similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate; uncharacterized protein 253318 34688164 LALA0_S12e02740g Lachancea lanzarotensis uncharacterized protein XP_022630809.1 252383 D 1245769 CDS LALA0_S12e02762g 34688165 254660..256813 Unknown 1 NW_019212890.1 similar to uniprot|P11938 Saccharomyces cerevisiae YNL216W RAP1 DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure; DNA-binding transcription factor RAP1 256813 34688165 LALA0_S12e02762g Lachancea lanzarotensis DNA-binding transcription factor RAP1 XP_022630810.1 254660 D 1245769 CDS LALA0_S12e02784g 34688166 complement(257009..259252) Unknown 1 NW_019212890.1 similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; GTPase-activating protein GYP7 259252 34688166 LALA0_S12e02784g Lachancea lanzarotensis GTPase-activating protein GYP7 XP_022630811.1 257009 R 1245769 CDS LALA0_S12e02806g 34688167 260148..260954 Unknown 1 NW_019212890.1 similar to uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions; uncharacterized protein 260954 34688167 LALA0_S12e02806g Lachancea lanzarotensis uncharacterized protein XP_022630812.1 260148 D 1245769 CDS LALA0_S12e02828g 34688168 261451..263253 Unknown 1 NW_019212890.1 some similarities with uniprot|Q07684 Saccharomyces cerevisiae YDL233W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene; uncharacterized protein 263253 34688168 LALA0_S12e02828g Lachancea lanzarotensis uncharacterized protein XP_022630813.1 261451 D 1245769 CDS LALA0_S12e02850g 34688169 264330..264953 Unknown 1 NW_019212890.1 weakly similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis; uncharacterized protein 264953 34688169 LALA0_S12e02850g Lachancea lanzarotensis uncharacterized protein XP_022630814.1 264330 D 1245769 CDS LALA0_S12e02872g 34688170 complement(265002..265712) Unknown 1 NW_019212890.1 similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C RRG9 Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 265712 34688170 LALA0_S12e02872g Lachancea lanzarotensis uncharacterized protein XP_022630815.1 265002 R 1245769 CDS LALA0_S12e02894g 34688171 266027..268438 Unknown 1 NW_019212890.1 similar to uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; uncharacterized protein 268438 34688171 LALA0_S12e02894g Lachancea lanzarotensis uncharacterized protein XP_022630816.1 266027 D 1245769 CDS LALA0_S12e02916g 34688172 complement(268651..268905) Unknown 1 NW_019212890.1 similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene; uncharacterized protein 268905 34688172 LALA0_S12e02916g Lachancea lanzarotensis uncharacterized protein XP_022630817.1 268651 R 1245769 CDS LALA0_S12e02938g 34688173 269085..269207 Unknown 1 NW_019212890.1 similar to uniprot|Q99380 Saccharomyces cerevisiae YDL232W OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex; olichyl-diphosphooligosaccharide--protein glycotransferase OST4 269207 34688173 LALA0_S12e02938g Lachancea lanzarotensis olichyl-diphosphooligosaccharide--protein glycotransferase OST4 XP_022630818.1 269085 D 1245769 CDS LALA0_S12e02960g 34688174 complement(269427..272579) Unknown 1 NW_019212890.1 similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; uncharacterized protein 272579 34688174 LALA0_S12e02960g Lachancea lanzarotensis uncharacterized protein XP_022630819.1 269427 R 1245769 CDS LALA0_S12e02982g 34688175 272777..273748 Unknown 1 NW_019212890.1 similar to uniprot|P25044 Saccharomyces cerevisiae YDL230W PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation; tyrosine protein phosphatase PTP1 273748 34688175 LALA0_S12e02982g Lachancea lanzarotensis tyrosine protein phosphatase PTP1 XP_022630820.1 272777 D 1245769 CDS LALA0_S12e03004g 34688176 274259..275236 Unknown 1 NW_019212890.1 weakly similar to uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22; uncharacterized protein 275236 34688176 LALA0_S12e03004g Lachancea lanzarotensis uncharacterized protein XP_022630821.1 274259 D 1245769 CDS LALA0_S12e03026g 34688177 275784..277625 Unknown 1 NW_019212890.1 highly similar to uniprot|P11484 Saccharomyces cerevisiae YDL229W (ohnolog of YNL209W) SSB1 Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; Hsp70 family ATPase SSB2 277625 34688177 LALA0_S12e03026g Lachancea lanzarotensis Hsp70 family ATPase SSB2 XP_022630822.1 275784 D 1245769 CDS LALA0_S12e03048g 34688178 278890..280167 Unknown 1 NW_019212890.1 highly similar to uniprot|P40160 Saccharomyces cerevisiae YNL207W RIO2 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p; protein kinase RIO2 280167 34688178 LALA0_S12e03048g Lachancea lanzarotensis protein kinase RIO2 XP_022630823.1 278890 D 1245769 CDS LALA0_S12e03070g 34688179 complement(280238..281611) Unknown 1 NW_019212890.1 similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; uncharacterized protein 281611 34688179 LALA0_S12e03070g Lachancea lanzarotensis uncharacterized protein XP_022630824.1 280238 R 1245769 CDS LALA0_S12e03092g 34688180 complement(282059..283162) Unknown 1 NW_019212890.1 similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C (ohnolog of YNL204C) GCS1 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p; uncharacterized protein 283162 34688180 LALA0_S12e03092g Lachancea lanzarotensis uncharacterized protein XP_022630825.1 282059 R 1245769 CDS LALA0_S12e03114g 34688181 284981..285853 Unknown 1 NW_019212890.1 highly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; 2,4-dienoyl-CoA reductase (NADPH) 285853 34688181 LALA0_S12e03114g Lachancea lanzarotensis 2,4-dienoyl-CoA reductase (NADPH) XP_022630826.1 284981 D 1245769 CDS LALA0_S12e03136g 34688182 complement(285872..288247) Unknown 1 NW_019212890.1 similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3; uncharacterized protein 288247 34688182 LALA0_S12e03136g Lachancea lanzarotensis uncharacterized protein XP_022630827.1 285872 R 1245769 CDS LALA0_S12e03158g 34688183 complement(289393..290124) Unknown 1 NW_019212890.1 highly similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; NADHX epimerase 290124 34688183 LALA0_S12e03158g Lachancea lanzarotensis NADHX epimerase XP_022630828.1 289393 R 1245769 CDS LALA0_S12e03180g 34688184 complement(290322..291731) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q01722 Saccharomyces cerevisiae YNL199C GCR2 Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p; uncharacterized protein 291731 34688184 LALA0_S12e03180g Lachancea lanzarotensis uncharacterized protein XP_022630829.1 290322 R 1245769 CDS LALA0_S12e03202g 34688185 293594..295237 Unknown 1 NW_019212890.1 similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis; septin SHS1 295237 34688185 LALA0_S12e03202g Lachancea lanzarotensis septin SHS1 XP_022630830.1 293594 D 1245769 CDS LALA0_S12e03224g 34688186 complement(295793..297664) Unknown 1 NW_019212890.1 similar to uniprot|Q07655 Saccharomyces cerevisiae YDL224C (ohnolog of YNL197C) WHI4 Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division; uncharacterized protein 297664 34688186 LALA0_S12e03224g Lachancea lanzarotensis uncharacterized protein XP_022630831.1 295793 R 1245769 CDS LALA0_S12e03246g 34688187 complement(300190..303177) Unknown 1 NW_019212890.1 weakly similar to uniprot|C5DCZ5 Lachancea thermotolerans KLTH0B07062g hypothetical protein; uncharacterized protein 303177 34688187 LALA0_S12e03246g Lachancea lanzarotensis uncharacterized protein XP_022630832.1 300190 R 1245769 CDS LALA0_S12e03268g 34688188 complement(303330..304241) Unknown 1 NW_019212890.1 similar to uniprot|Q07651 Saccharomyces cerevisiae YDL222C (ohnolog of YNL194C) FMP45 Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C; uncharacterized protein 304241 34688188 LALA0_S12e03268g Lachancea lanzarotensis uncharacterized protein XP_022630833.1 303330 R 1245769 CDS LALA0_S12e03290g 34688189 complement(305067..307769) Unknown 1 NW_019212890.1 weakly similar to uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; telomere-binding protein CDC13 307769 34688189 LALA0_S12e03290g Lachancea lanzarotensis telomere-binding protein CDC13 XP_022630834.1 305067 R 1245769 CDS LALA0_S12e03312g 34688190 307948..309483 Unknown 1 NW_019212890.1 similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis; uncharacterized protein 309483 34688190 LALA0_S12e03312g Lachancea lanzarotensis uncharacterized protein XP_022630835.1 307948 D 1245769 CDS LALA0_S12e03334g 34688191 309782..312958 Unknown 1 NW_019212890.1 similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor; chitin synthase I 312958 34688191 LALA0_S12e03334g Lachancea lanzarotensis chitin synthase I XP_022630836.1 309782 D 1245769 CDS LALA0_S12e03356g 34688192 join(313156..313220,313278..313665) Unknown 1 NW_019212890.1 highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; D-tyrosyl-tRNA(Tyr) deacylase 313665 34688192 LALA0_S12e03356g Lachancea lanzarotensis D-tyrosyl-tRNA(Tyr) deacylase XP_022630837.1 313156 D 1245769 CDS LALA0_S12e03378g 34688193 join(313912..313936,314028..315073) Unknown 1 NW_019212890.1 highly similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W DUG3 Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); glutamine amidotransferase subunit DUG3 315073 34688193 LALA0_S12e03378g Lachancea lanzarotensis glutamine amidotransferase subunit DUG3 XP_022630838.1 313912 D 1245769 CDS LALA0_S12e03400g 34688194 315809..316954 Unknown 1 NW_019212890.1 weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin; uncharacterized protein 316954 34688194 LALA0_S12e03400g Lachancea lanzarotensis uncharacterized protein XP_022630839.1 315809 D 1245769 CDS LALA0_S12e03422g 34688195 318668..319243 Unknown 1 NW_019212890.1 similar to uniprot|P53872 Saccharomyces cerevisiae YNL190W Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site; uncharacterized protein 319243 34688195 LALA0_S12e03422g Lachancea lanzarotensis uncharacterized protein XP_022630840.1 318668 D 1245769 CDS LALA0_S12e03444g 34688196 320107..321732 Unknown 1 NW_019212890.1 highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation; karyopherin alpha 321732 34688196 LALA0_S12e03444g Lachancea lanzarotensis karyopherin alpha XP_022630841.1 320107 D 1245769 CDS LALA0_S12e03466g 34688197 322094..323125 Unknown 1 NW_019212890.1 weakly similar to uniprot|P11927 Saccharomyces cerevisiae YNL188W KAR1 Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p; uncharacterized protein 323125 34688197 LALA0_S12e03466g Lachancea lanzarotensis uncharacterized protein XP_022630842.1 322094 D 1245769 CDS LALA0_S12e03488g 34688198 complement(323236..323826) Unknown 1 NW_019212890.1 highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported; translocation channel protein TIM22 323826 34688198 LALA0_S12e03488g Lachancea lanzarotensis translocation channel protein TIM22 XP_022630843.1 323236 R 1245769 CDS LALA0_S12e03510g 34688199 324039..325301 Unknown 1 NW_019212890.1 weakly similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W SWT21 Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats; uncharacterized protein 325301 34688199 LALA0_S12e03510g Lachancea lanzarotensis uncharacterized protein XP_022630844.1 324039 D 1245769 CDS LALA0_S12e03532g 34688200 complement(325318..326577) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; COP9 signalosome catalytic subunit RRI1 326577 34688200 LALA0_S12e03532g Lachancea lanzarotensis COP9 signalosome catalytic subunit RRI1 XP_022630845.1 325318 R 1245769 CDS LALA0_S12e03554g 34688201 complement(326764..329946) Unknown 1 NW_019212890.1 similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; glutamate dehydrogenase (NAD(+)) 329946 34688201 LALA0_S12e03554g Lachancea lanzarotensis glutamate dehydrogenase (NAD(+)) XP_022630846.1 326764 R 1245769 CDS LALA0_S12e03576g 34688202 331283..333514 Unknown 1 NW_019212890.1 similar to uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus; ubiquitin-specific protease UBP10 333514 34688202 LALA0_S12e03576g Lachancea lanzarotensis ubiquitin-specific protease UBP10 XP_022630847.1 331283 D 1245769 CDS LALA0_S12e03598g 34688203 complement(333711..334160) Unknown 1 NW_019212890.1 highly similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL11m 334160 34688203 LALA0_S12e03598g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL11m XP_022630848.1 333711 R 1245769 CDS LALA0_S12e03620g 34688204 complement(334801..337092) Unknown 1 NW_019212890.1 similar to uniprot|Q12310 Saccharomyces cerevisiae YDL214C (ohnolog of YNL183C) PRR2 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; serine/threonine protein kinase NPR1 337092 34688204 LALA0_S12e03620g Lachancea lanzarotensis serine/threonine protein kinase NPR1 XP_022630849.1 334801 R 1245769 CDS LALA0_S12e03642g 34688205 complement(337959..338588) Unknown 1 NW_019212890.1 similar to uniprot|Q07623 Saccharomyces cerevisiae YDL213C NOP6 rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes; uncharacterized protein 338588 34688205 LALA0_S12e03642g Lachancea lanzarotensis uncharacterized protein XP_022630850.1 337959 R 1245769 CDS LALA0_S12e03664g 34688206 338803..339120 Unknown 1 NW_019212890.1 similar to Lachancea thermotolerans KLTH0B06908g hypothetical protein; uncharacterized protein 339120 34688206 LALA0_S12e03664g Lachancea lanzarotensis uncharacterized protein XP_022630851.1 338803 D 1245769 CDS LALA0_S12e03686g 34688207 complement(339217..340737) Unknown 1 NW_019212890.1 similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles; chromatin-binding/pre-rRNA-processing protein IPI3 340737 34688207 LALA0_S12e03686g Lachancea lanzarotensis chromatin-binding/pre-rRNA-processing protein IPI3 XP_022630852.1 339217 R 1245769 CDS LALA0_S12e03708g 34688208 340905..342077 Unknown 1 NW_019212890.1 similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Putative oxidoreductase; required for cell viability; uncharacterized protein 342077 34688208 LALA0_S12e03708g Lachancea lanzarotensis uncharacterized protein XP_022630853.1 340905 D 1245769 CDS LALA0_S12e03730g 34688209 complement(342202..342984) Unknown 1 NW_019212890.1 similar to uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; Rho family GTPase RHO5 342984 34688209 LALA0_S12e03730g Lachancea lanzarotensis Rho family GTPase RHO5 XP_022630854.1 342202 R 1245769 CDS LALA0_S12e03752g 34688210 344934..346082 Unknown 1 NW_019212890.1 some similarities with uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; uncharacterized protein 346082 34688210 LALA0_S12e03752g Lachancea lanzarotensis uncharacterized protein XP_022630855.1 344934 D 1245769 CDS LALA0_S12e03774g 34688211 346791..347534 Unknown 1 NW_019212890.1 highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins; 40S ribosomal protein uS3 347534 34688211 LALA0_S12e03774g Lachancea lanzarotensis 40S ribosomal protein uS3 XP_022630856.1 346791 D 1245769 CDS LALA0_S12e03796g 34688212 348458..349048 Unknown 1 NW_019212890.1 similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; uncharacterized protein 349048 34688212 LALA0_S12e03796g Lachancea lanzarotensis uncharacterized protein XP_022630857.1 348458 D 1245769 CDS LALA0_S12e03818g 34688213 complement(349170..350075) Unknown 1 NW_019212890.1 similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL22m 350075 34688213 LALA0_S12e03818g Lachancea lanzarotensis mitochondrial 54S ribosomal protein uL22m XP_022630858.1 349170 R 1245769 CDS LALA0_S12e03840g 34688214 complement(350595..351713) Unknown 1 NW_019212890.1 similar to Lachancea thermotolerans KLTH0B06908g hypothetical protein; uncharacterized protein 351713 34688214 LALA0_S12e03840g Lachancea lanzarotensis uncharacterized protein XP_022630859.1 350595 R 1245769 CDS LALA0_S12e03862g 34688215 complement(352142..353344) Unknown 1 NW_019212890.1 similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C NOP13 Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); uncharacterized protein 353344 34688215 LALA0_S12e03862g Lachancea lanzarotensis uncharacterized protein XP_022630860.1 352142 R 1245769 CDS LALA0_S12e03884g 34688216 complement(353799..355898) Unknown 1 NW_019212890.1 some similarities with uniprot|P38845 Saccharomyces cerevisiae YHR146W (ohnolog of YNL173C) CRP1 Protein that binds to cruciform DNA structures; uncharacterized protein 355898 34688216 LALA0_S12e03884g Lachancea lanzarotensis uncharacterized protein XP_022630861.1 353799 R 1245769 CDS LALA0_S12e03928g 34688218 361243..366369 Unknown 1 NW_019212890.1 similar to uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; anaphase promoting complex subunit 1 366369 34688218 LALA0_S12e03928g Lachancea lanzarotensis anaphase promoting complex subunit 1 XP_022630862.1 361243 D 1245769 CDS LALA0_S12e03950g 34688219 complement(366455..367969) Unknown 1 NW_019212890.1 similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine; phosphatidylserine decarboxylase 1 367969 34688219 LALA0_S12e03950g Lachancea lanzarotensis phosphatidylserine decarboxylase 1 XP_022630863.1 366455 R 1245769 CDS LALA0_S12e03972g 34688220 368950..369921 Unknown 1 NW_019212890.1 similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated; deoxycytidine monophosphate deaminase 369921 34688220 LALA0_S12e03972g Lachancea lanzarotensis deoxycytidine monophosphate deaminase XP_022630864.1 368950 D 1245769 CDS LALA0_S12e03994g 34688221 complement(370354..372288) Unknown 1 NW_019212890.1 weakly similar to uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses; uncharacterized protein 372288 34688221 LALA0_S12e03994g Lachancea lanzarotensis uncharacterized protein XP_022630865.1 370354 R 1245769 CDS LALA0_S13e00100g 34688222 complement(join(1..255,259..1593)) Unknown 1 NW_019212891.1 some similarities with uniprot|P08068 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); 1593 34688222 LALA0_S13e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S13e00122g 34688223 complement(4493..6511) Unknown 1 NW_019212891.1 weakly similar to uniprot|P36033 Saccharomyces cerevisiae YKL220C FRE2 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; uncharacterized protein 6511 34688223 LALA0_S13e00122g Lachancea lanzarotensis uncharacterized protein XP_022630866.1 4493 R 1245769 CDS LALA0_S13e00144g 34688224 complement(7304..8404) Unknown 1 NW_019212891.1 similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme; ubiquinol--cytochrome-c reductase subunit 2 8404 34688224 LALA0_S13e00144g Lachancea lanzarotensis ubiquinol--cytochrome-c reductase subunit 2 XP_022630867.1 7304 R 1245769 CDS LALA0_S13e00166g 34688225 9869..11737 Unknown 1 NW_019212891.1 similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82; DNA-directed RNA polymerase III subunit C82 11737 34688225 LALA0_S13e00166g Lachancea lanzarotensis DNA-directed RNA polymerase III subunit C82 XP_022630868.1 9869 D 1245769 CDS LALA0_S13e00188g 34688226 complement(11775..15995) Unknown 1 NW_019212891.1 similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; SKI complex subunit tetratricopeptide repeat protein SKI3 15995 34688226 LALA0_S13e00188g Lachancea lanzarotensis SKI complex subunit tetratricopeptide repeat protein SKI3 XP_022630869.1 11775 R 1245769 CDS LALA0_S13e00210g 34688227 16724..17191 Unknown 1 NW_019212891.1 similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring; uncharacterized protein 17191 34688227 LALA0_S13e00210g Lachancea lanzarotensis uncharacterized protein XP_022630870.1 16724 D 1245769 CDS LALA0_S13e00232g 34688228 complement(join(17637..18087,18210..18229)) Unknown 1 NW_019212891.1 highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; DNA-directed RNA polymerase core subunit RPO26 18229 34688228 LALA0_S13e00232g Lachancea lanzarotensis DNA-directed RNA polymerase core subunit RPO26 XP_022630871.1 17637 R 1245769 CDS LALA0_S13e00254g 34688229 18824..20116 Unknown 1 NW_019212891.1 similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA; uncharacterized protein 20116 34688229 LALA0_S13e00254g Lachancea lanzarotensis uncharacterized protein XP_022630872.1 18824 D 1245769 CDS LALA0_S13e00276g 34688230 complement(20302..22368) Unknown 1 NW_019212891.1 similar to uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling; serine/threonine protein kinase regulatory subunit ATG13 22368 34688230 LALA0_S13e00276g Lachancea lanzarotensis serine/threonine protein kinase regulatory subunit ATG13 XP_022630873.1 20302 R 1245769 CDS LALA0_S13e00298g 34688231 complement(23289..27854) Unknown 1 NW_019212891.1 highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase 27854 34688231 LALA0_S13e00298g Lachancea lanzarotensis bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase XP_022630874.1 23289 R 1245769 CDS LALA0_S13e00320g 34688232 complement(28576..29373) Unknown 1 NW_019212891.1 highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation; dolichyl-phosphate beta-D-mannosyltransferase 29373 34688232 LALA0_S13e00320g Lachancea lanzarotensis dolichyl-phosphate beta-D-mannosyltransferase XP_022630875.1 28576 R 1245769 CDS LALA0_S13e00342g 34688233 complement(join(29776..30114,30173..30181)) Unknown 1 NW_019212891.1 some similarities with uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F; mRNA splicing protein SMX3 30181 34688233 LALA0_S13e00342g Lachancea lanzarotensis mRNA splicing protein SMX3 XP_022630876.1 29776 R 1245769 CDS LALA0_S13e00364g 34688234 complement(30616..31788) Unknown 1 NW_019212891.1 similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI; GPI-anchor transamidase subunit GAB1 31788 34688234 LALA0_S13e00364g Lachancea lanzarotensis GPI-anchor transamidase subunit GAB1 XP_022630877.1 30616 R 1245769 CDS LALA0_S13e00386g 34688235 33740..36043 Unknown 1 NW_019212891.1 highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; GTPase-activating protein SEC23 36043 34688235 LALA0_S13e00386g Lachancea lanzarotensis GTPase-activating protein SEC23 XP_022630878.1 33740 D 1245769 CDS LALA0_S13e00408g 34688236 complement(36315..37259) Unknown 1 NW_019212891.1 similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; E1 ubiquitin-activating protein AOS1 37259 34688236 LALA0_S13e00408g Lachancea lanzarotensis E1 ubiquitin-activating protein AOS1 XP_022630879.1 36315 R 1245769 CDS LALA0_S13e00430g 34688237 38401..40344 Unknown 1 NW_019212891.1 similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p; uncharacterized protein 40344 34688237 LALA0_S13e00430g Lachancea lanzarotensis uncharacterized protein XP_022630880.1 38401 D 1245769 CDS LALA0_S13e00452g 34688238 complement(40387..41817) Unknown 1 NW_019212891.1 similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor, component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP4 41817 34688238 LALA0_S13e00452g Lachancea lanzarotensis U4/U6-U5 snRNP complex subunit PRP4 XP_022630881.1 40387 R 1245769 CDS LALA0_S13e00474g 34688239 41957..42955 Unknown 1 NW_019212891.1 highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; Rab geranylgeranyltransferase BET2 42955 34688239 LALA0_S13e00474g Lachancea lanzarotensis Rab geranylgeranyltransferase BET2 XP_022630882.1 41957 D 1245769 CDS LALA0_S13e00496g 34688240 complement(43008..45053) Unknown 1 NW_019212891.1 similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate; DNA polymerase epsilon noncatalytic subunit 45053 34688240 LALA0_S13e00496g Lachancea lanzarotensis DNA polymerase epsilon noncatalytic subunit XP_022630883.1 43008 R 1245769 CDS LALA0_S13e00518g 34688241 45490..46479 Unknown 1 NW_019212891.1 weakly similar to uniprot|Q06616 Saccharomyces cerevisiae YPR174C (ohnolog of YLR457C) Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; uncharacterized protein 46479 34688241 LALA0_S13e00518g Lachancea lanzarotensis uncharacterized protein XP_022630884.1 45490 D 1245769 CDS LALA0_S13e00540g 34688242 46724..48016 Unknown 1 NW_019212891.1 highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism; AAA family ATPase VPS4 48016 34688242 LALA0_S13e00540g Lachancea lanzarotensis AAA family ATPase VPS4 XP_022630885.1 46724 D 1245769 CDS LALA0_S13e00562g 34688243 complement(48166..48813) Unknown 1 NW_019212891.1 similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W (ohnolog of YLR456W) Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; pyridoxal 5'-phosphate synthase 48813 34688243 LALA0_S13e00562g Lachancea lanzarotensis pyridoxal 5'-phosphate synthase XP_022630886.1 48166 R 1245769 CDS LALA0_S13e00584g 34688244 complement(49241..50161) Unknown 1 NW_019212891.1 similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); uncharacterized protein 50161 34688244 LALA0_S13e00584g Lachancea lanzarotensis uncharacterized protein XP_022630887.1 49241 R 1245769 CDS LALA0_S13e00606g 34688245 51045..52655 Unknown 1 NW_019212891.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); uncharacterized protein 52655 34688245 LALA0_S13e00606g Lachancea lanzarotensis uncharacterized protein XP_022630888.1 51045 D 1245769 CDS LALA0_S13e00628g 34688246 complement(52717..54654) Unknown 1 NW_019212891.1 weakly similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton; uncharacterized protein 54654 34688246 LALA0_S13e00628g Lachancea lanzarotensis uncharacterized protein XP_022630889.1 52717 R 1245769 CDS LALA0_S13e00650g 34688247 complement(join(54975..55083,55244..55374,55545..55562)) Unknown 1 NW_019212891.1 highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C; uncharacterized protein 55562 34688247 LALA0_S13e00650g Lachancea lanzarotensis uncharacterized protein XP_022630890.1 54975 R 1245769 CDS LALA0_S13e00694g 34688249 complement(join(56033..56447,56896..56915)) Unknown 1 NW_019212891.1 highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C (ohnolog of YNL302C) RPS19A Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp; 40S ribosomal protein eS19 56915 34688249 LALA0_S13e00694g Lachancea lanzarotensis 40S ribosomal protein eS19 XP_022630891.1 56033 R 1245769 CDS LALA0_S13e00716g 34688250 complement(join(57574..58022,58469..58580)) Unknown 1 NW_019212891.1 highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C (ohnolog of YNL301C) RPL18A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; 60S ribosomal protein eL18 58580 34688250 LALA0_S13e00716g Lachancea lanzarotensis 60S ribosomal protein eL18 XP_022630892.1 57574 R 1245769 CDS LALA0_S13e00738g 34688251 complement(59094..60554) Unknown 1 NW_019212891.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; uncharacterized protein 60554 34688251 LALA0_S13e00738g Lachancea lanzarotensis uncharacterized protein XP_022630893.1 59094 R 1245769 CDS LALA0_S13e00760g 34688252 complement(61799..62371) Unknown 1 NW_019212891.1 weakly similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; thioredoxin peroxidase AHP1 62371 34688252 LALA0_S13e00760g Lachancea lanzarotensis thioredoxin peroxidase AHP1 XP_022630894.1 61799 R 1245769 CDS LALA0_S13e00782g 34688253 63121..64932 Unknown 1 NW_019212891.1 weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response; uncharacterized protein 64932 34688253 LALA0_S13e00782g Lachancea lanzarotensis uncharacterized protein XP_022630895.1 63121 D 1245769 CDS LALA0_S13e00804g 34688254 65507..65935 Unknown 1 NW_019212891.1 some similarities with uniprot|P48560 Saccharomyces cerevisiae YNL300W TOS6 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid; uncharacterized protein 65935 34688254 LALA0_S13e00804g Lachancea lanzarotensis uncharacterized protein XP_022630896.1 65507 D 1245769 CDS LALA0_S13e00826g 34688255 66995..69022 Unknown 1 NW_019212891.1 similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W (ohnolog of YNL299W) PAP2 Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p; non-canonical poly(A) polymerase TRF5 69022 34688255 LALA0_S13e00826g Lachancea lanzarotensis non-canonical poly(A) polymerase TRF5 XP_022630897.1 66995 D 1245769 CDS LALA0_S13e00848g 34688256 complement(69108..69659) Unknown 1 NW_019212891.1 similar to uniprot|Q12322 Saccharomyces cerevisiae YOL114C Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene; uncharacterized protein 69659 34688256 LALA0_S13e00848g Lachancea lanzarotensis uncharacterized protein XP_022630898.1 69108 R 1245769 CDS LALA0_S13e00870g 34688257 71340..73904 Unknown 1 NW_019212891.1 similar to uniprot|Q12469 Saccharomyces cerevisiae YOL113W (ohnolog of YNL298W) SKM1 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; serine/threonine protein kinase CLA4 73904 34688257 LALA0_S13e00870g Lachancea lanzarotensis serine/threonine protein kinase CLA4 XP_022630899.1 71340 D 1245769 CDS LALA0_S13e00892g 34688258 complement(73977..78815) Unknown 1 NW_019212891.1 similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; uncharacterized protein 78815 34688258 LALA0_S13e00892g Lachancea lanzarotensis uncharacterized protein XP_022630900.1 73977 R 1245769 CDS LALA0_S13e00936g 34688260 79445..80836 Unknown 1 NW_019212891.1 similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W Putative protein of unknown function; uncharacterized protein 80836 34688260 LALA0_S13e00936g Lachancea lanzarotensis uncharacterized protein XP_022630901.1 79445 D 1245769 CDS LALA0_S13e00958g 34688261 complement(80946..82502) Unknown 1 NW_019212891.1 similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH; uncharacterized protein 82502 34688261 LALA0_S13e00958g Lachancea lanzarotensis uncharacterized protein XP_022630902.1 80946 R 1245769 CDS LALA0_S13e00980g 34688262 84456..86165 Unknown 1 NW_019212891.1 similar to uniprot|Q12317 Saccharomyces cerevisiae YOL112W (ohnolog of YNL293W) MSB4 GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization; Rab GTPase-activating protein MSB3 86165 34688262 LALA0_S13e00980g Lachancea lanzarotensis Rab GTPase-activating protein MSB3 XP_022630903.1 84456 D 1245769 CDS LALA0_S13e01002g 34688263 complement(86288..86992) Unknown 1 NW_019212891.1 similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C MDY2 Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes; uncharacterized protein 86992 34688263 LALA0_S13e01002g Lachancea lanzarotensis uncharacterized protein XP_022630904.1 86288 R 1245769 CDS LALA0_S13e01024g 34688264 87823..88491 Unknown 1 NW_019212891.1 similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; uncharacterized protein 88491 34688264 LALA0_S13e01024g Lachancea lanzarotensis uncharacterized protein XP_022630905.1 87823 D 1245769 CDS LALA0_S13e01046g 34688265 88842..90077 Unknown 1 NW_019212891.1 similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype); uncharacterized protein 90077 34688265 LALA0_S13e01046g Lachancea lanzarotensis uncharacterized protein XP_022630906.1 88842 D 1245769 CDS LALA0_S13e01068g 34688266 complement(90078..91682) Unknown 1 NW_019212891.1 similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer; uncharacterized protein 91682 34688266 LALA0_S13e01068g Lachancea lanzarotensis uncharacterized protein XP_022630907.1 90078 R 1245769 CDS LALA0_S13e01112g 34688268 93202..94191 Unknown 1 NW_019212891.1 highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 3 94191 34688268 LALA0_S13e01112g Lachancea lanzarotensis replication factor C subunit 3 XP_022630908.1 93202 D 1245769 CDS LALA0_S13e01134g 34688269 95647..96441 Unknown 1 NW_019212891.1 similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; uncharacterized protein 96441 34688269 LALA0_S13e01134g Lachancea lanzarotensis uncharacterized protein XP_022630909.1 95647 D 1245769 CDS LALA0_S13e01156g 34688270 98043..98711 Unknown 1 NW_019212891.1 highly similar to uniprot|C5DBD3 Lachancea thermotolerans KLTH0A01628g hypothetical protein; uncharacterized protein 98711 34688270 LALA0_S13e01156g Lachancea lanzarotensis uncharacterized protein XP_022630910.1 98043 D 1245769 CDS LALA0_S13e01178g 34688271 100189..100527 Unknown 1 NW_019212891.1 hypothetical protein; uncharacterized protein 100527 34688271 LALA0_S13e01178g Lachancea lanzarotensis uncharacterized protein XP_022630911.1 100189 D 1245769 CDS LALA0_S13e01200g 34688272 101348..102370 Unknown 1 NW_019212891.1 similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p; CCR4-NOT core subunit CAF40 102370 34688272 LALA0_S13e01200g Lachancea lanzarotensis CCR4-NOT core subunit CAF40 XP_022630912.1 101348 D 1245769 CDS LALA0_S13e01222g 34688273 102887..105688 Unknown 1 NW_019212891.1 highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo; coatomer subunit gamma 105688 34688273 LALA0_S13e01222g Lachancea lanzarotensis coatomer subunit gamma XP_022630913.1 102887 D 1245769 CDS LALA0_S13e01244g 34688274 105851..106753 Unknown 1 NW_019212891.1 similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); U2 snRNP complex subunit CUS2 106753 34688274 LALA0_S13e01244g Lachancea lanzarotensis U2 snRNP complex subunit CUS2 XP_022630914.1 105851 D 1245769 CDS LALA0_S13e01310g 34688277 complement(107443..109866) Unknown 1 NW_019212891.1 weakly similar to uniprot|P43596 Saccharomyces cerevisiae YFR013W (ohnolog of YOL017W) IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing; uncharacterized protein 109866 34688277 LALA0_S13e01310g Lachancea lanzarotensis uncharacterized protein XP_022630915.1 107443 R 1245769 CDS LALA0_S13e01332g 34688278 complement(110503..111402) Unknown 1 NW_019212891.1 highly similar to uniprot|C5E390 Lachancea thermotolerans KLTH0H11308g hypothetical protein; uncharacterized protein 111402 34688278 LALA0_S13e01332g Lachancea lanzarotensis uncharacterized protein XP_022630916.1 110503 R 1245769 CDS LALA0_S13e01354g 34688279 112011..114026 Unknown 1 NW_019212891.1 similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 114026 34688279 LALA0_S13e01354g Lachancea lanzarotensis uncharacterized protein XP_022630917.1 112011 D 1245769 CDS LALA0_S13e01376g 34688280 complement(114043..115281) Unknown 1 NW_019212891.1 similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W AIM22 Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss; uncharacterized protein 115281 34688280 LALA0_S13e01376g Lachancea lanzarotensis uncharacterized protein XP_022630918.1 114043 R 1245769 CDS LALA0_S13e01398g 34688281 115442..116263 Unknown 1 NW_019212891.1 similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; RNase P/RNase MRP complex subunit 116263 34688281 LALA0_S13e01398g Lachancea lanzarotensis RNase P/RNase MRP complex subunit XP_022630919.1 115442 D 1245769 CDS LALA0_S13e01420g 34688282 complement(116289..116714) Unknown 1 NW_019212891.1 weakly similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; uncharacterized protein 116714 34688282 LALA0_S13e01420g Lachancea lanzarotensis uncharacterized protein XP_022630920.1 116289 R 1245769 CDS LALA0_S13e01442g 34688283 116993..118963 Unknown 1 NW_019212891.1 weakly similar to uniprot|P38338 Saccharomyces cerevisiae YBR259W (ohnolog of YJL047C) Putative protein of unknown function; YBR259W is not an essential gene; uncharacterized protein 118963 34688283 LALA0_S13e01442g Lachancea lanzarotensis uncharacterized protein XP_022630921.1 116993 D 1245769 CDS LALA0_S13e01464g 34688284 119558..121879 Unknown 1 NW_019212891.1 weakly similar to uniprot|P38338 Saccharomyces cerevisiae YBR259W (ohnolog of YJL047C) Putative protein of unknown function; YBR259W is not an essential gene; cullin RTT101 121879 34688284 LALA0_S13e01464g Lachancea lanzarotensis cullin RTT101 XP_022630922.1 119558 D 1245769 CDS LALA0_S13e01486g 34688285 complement(122024..124123) Unknown 1 NW_019212891.1 similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization; GTPase-activating protein RGD1 124123 34688285 LALA0_S13e01486g Lachancea lanzarotensis GTPase-activating protein RGD1 XP_022630923.1 122024 R 1245769 CDS LALA0_S13e01508g 34688286 complement(126005..126700) Unknown 1 NW_019212891.1 highly similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C TAE1 AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm; N-terminal protein methyltransferase 126700 34688286 LALA0_S13e01508g Lachancea lanzarotensis N-terminal protein methyltransferase XP_022630924.1 126005 R 1245769 CDS LALA0_S13e01530g 34688287 complement(127868..128158) Unknown 1 NW_019212891.1 similar to uniprot|P38341 Saccharomyces cerevisiae YBR262C AIM5 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 128158 34688287 LALA0_S13e01530g Lachancea lanzarotensis uncharacterized protein XP_022630925.1 127868 R 1245769 CDS LALA0_S13e01552g 34688288 join(129307..129316,129385..130865) Unknown 1 NW_019212891.1 highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; uncharacterized protein 130865 34688288 LALA0_S13e01552g Lachancea lanzarotensis uncharacterized protein XP_022630926.1 129307 D 1245769 CDS LALA0_S13e01574g 34688289 complement(131184..131621) Unknown 1 NW_019212891.1 similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL41 131621 34688289 LALA0_S13e01574g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL41 XP_022630927.1 131184 R 1245769 CDS LALA0_S13e01596g 34688290 complement(131984..133717) Unknown 1 NW_019212891.1 similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; uncharacterized protein 133717 34688290 LALA0_S13e01596g Lachancea lanzarotensis uncharacterized protein XP_022630928.1 131984 R 1245769 CDS LALA0_S13e01618g 34688291 135213..137789 Unknown 1 NW_019212891.1 similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C DUG2 Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); glutamine amidotransferase subunit DUG2 137789 34688291 LALA0_S13e01618g Lachancea lanzarotensis glutamine amidotransferase subunit DUG2 XP_022630929.1 135213 D 1245769 CDS LALA0_S13e01640g 34688292 138039..139778 Unknown 1 NW_019212891.1 similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C SAF1 F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1; SCF ubiquitin ligase complex subunit SAF1 139778 34688292 LALA0_S13e01640g Lachancea lanzarotensis SCF ubiquitin ligase complex subunit SAF1 XP_022630930.1 138039 D 1245769 CDS LALA0_S13e01662g 34688293 complement(139828..140736) Unknown 1 NW_019212891.1 similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D; S-formylglutathione hydrolase 140736 34688293 LALA0_S13e01662g Lachancea lanzarotensis S-formylglutathione hydrolase XP_022630931.1 139828 R 1245769 CDS LALA0_S13e01684g 34688294 complement(141034..142293) Unknown 1 NW_019212891.1 similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; uncharacterized protein 142293 34688294 LALA0_S13e01684g Lachancea lanzarotensis uncharacterized protein XP_022630932.1 141034 R 1245769 CDS LALA0_S13e01706g 34688295 complement(142760..143632) Unknown 1 NW_019212891.1 weakly similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches; uncharacterized protein 143632 34688295 LALA0_S13e01706g Lachancea lanzarotensis uncharacterized protein XP_022630933.1 142760 R 1245769 CDS LALA0_S13e01728g 34688296 complement(143956..144651) Unknown 1 NW_019212891.1 some similarities with uniprot|P40366 Saccharomyces cerevisiae YJL065C (ohnolog of YBR278W) DLS1 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; uncharacterized protein 144651 34688296 LALA0_S13e01728g Lachancea lanzarotensis uncharacterized protein XP_022630934.1 143956 R 1245769 CDS LALA0_S13e01750g 34688297 146016..148406 Unknown 1 NW_019212891.1 weakly similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; tyrosine/serine/threonine protein phosphatase PPS1 148406 34688297 LALA0_S13e01750g Lachancea lanzarotensis tyrosine/serine/threonine protein phosphatase PPS1 XP_022630935.1 146016 D 1245769 CDS LALA0_S13e01772g 34688298 complement(148479..149525) Unknown 1 NW_019212891.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Putative cysteine synthase, localized to the mitochondrial outer membrane; uncharacterized protein 149525 34688298 LALA0_S13e01772g Lachancea lanzarotensis uncharacterized protein XP_022630936.1 148479 R 1245769 CDS LALA0_S13e01794g 34688299 complement(149849..150568) Unknown 1 NW_019212891.1 similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL17m 150568 34688299 LALA0_S13e01794g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL17m XP_022630937.1 149849 R 1245769 CDS LALA0_S13e01816g 34688300 151442..151711 Unknown 1 NW_019212891.1 similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A COA3 Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly; uncharacterized protein 151711 34688300 LALA0_S13e01816g Lachancea lanzarotensis uncharacterized protein XP_022630938.1 151442 D 1245769 CDS LALA0_S13e01838g 34688301 151993..152931 Unknown 1 NW_019212891.1 similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family; 3-dehydrosphinganine reductase 152931 34688301 LALA0_S13e01838g Lachancea lanzarotensis 3-dehydrosphinganine reductase XP_022630939.1 151993 D 1245769 CDS LALA0_S13e01860g 34688302 153437..154654 Unknown 1 NW_019212891.1 similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network; uncharacterized protein 154654 34688302 LALA0_S13e01860g Lachancea lanzarotensis uncharacterized protein XP_022630940.1 153437 D 1245769 CDS LALA0_S13e01882g 34688303 155001..157454 Unknown 1 NW_019212891.1 similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity; mannose-ethanolamine phosphotransferase LAS21 157454 34688303 LALA0_S13e01882g Lachancea lanzarotensis mannose-ethanolamine phosphotransferase LAS21 XP_022630941.1 155001 D 1245769 CDS LALA0_S13e01904g 34688304 157650..157970 Unknown 1 NW_019212891.1 similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL54 157970 34688304 LALA0_S13e01904g Lachancea lanzarotensis mitochondrial 54S ribosomal protein mL54 XP_022630942.1 157650 D 1245769 CDS LALA0_S13e01926g 34688305 158249..160309 Unknown 1 NW_019212891.1 weakly similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC; linker nucleoporin NUP82 160309 34688305 LALA0_S13e01926g Lachancea lanzarotensis linker nucleoporin NUP82 XP_022630943.1 158249 D 1245769 CDS LALA0_S13e01948g 34688306 complement(160495..160890) Unknown 1 NW_019212891.1 similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 160890 34688306 LALA0_S13e01948g Lachancea lanzarotensis uncharacterized protein XP_022630944.1 160495 R 1245769 CDS LALA0_S13e01970g 34688307 162990..164351 Unknown 1 NW_019212891.1 similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis; uncharacterized protein 164351 34688307 LALA0_S13e01970g Lachancea lanzarotensis uncharacterized protein XP_022630945.1 162990 D 1245769 CDS LALA0_S13e01992g 34688308 complement(164427..164906) Unknown 1 NW_019212891.1 highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; lumazine synthase RIB4 164906 34688308 LALA0_S13e01992g Lachancea lanzarotensis lumazine synthase RIB4 XP_022630946.1 164427 R 1245769 CDS LALA0_S13e02014g 34688309 165870..166307 Unknown 1 NW_019212891.1 similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain; uncharacterized protein 166307 34688309 LALA0_S13e02014g Lachancea lanzarotensis uncharacterized protein XP_022630947.1 165870 D 1245769 CDS LALA0_S13e02036g 34688310 166652..169777 Unknown 1 NW_019212891.1 similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; AAA family ATPase peroxin 6 169777 34688310 LALA0_S13e02036g Lachancea lanzarotensis AAA family ATPase peroxin 6 XP_022630948.1 166652 D 1245769 CDS LALA0_S13e02058g 34688311 170368..171666 Unknown 1 NW_019212891.1 highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; histone deacetylase RPD3 171666 34688311 LALA0_S13e02058g Lachancea lanzarotensis histone deacetylase RPD3 XP_022630949.1 170368 D 1245769 CDS LALA0_S13e02080g 34688312 172804..175437 Unknown 1 NW_019212891.1 weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; uncharacterized protein 175437 34688312 LALA0_S13e02080g Lachancea lanzarotensis uncharacterized protein XP_022630950.1 172804 D 1245769 CDS LALA0_S13e02102g 34688313 complement(175578..176585) Unknown 1 NW_019212891.1 similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions; palmitoyltransferase PFA3 176585 34688313 LALA0_S13e02102g Lachancea lanzarotensis palmitoyltransferase PFA3 XP_022630951.1 175578 R 1245769 CDS LALA0_S13e02124g 34688314 177398..178108 Unknown 1 NW_019212891.1 similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3); exosome non-catalytic core subunit RRP40 178108 34688314 LALA0_S13e02124g Lachancea lanzarotensis exosome non-catalytic core subunit RRP40 XP_022630952.1 177398 D 1245769 CDS LALA0_S13e02146g 34688315 complement(178155..180710) Unknown 1 NW_019212891.1 similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; phosphatidylinositol-3,5-bisphosphate 5-phosphatase 180710 34688315 LALA0_S13e02146g Lachancea lanzarotensis phosphatidylinositol-3,5-bisphosphate 5-phosphatase XP_022630953.1 178155 R 1245769 CDS LALA0_S13e02168g 34688316 182181..184190 Unknown 1 NW_019212891.1 similar to uniprot|Q08282 Saccharomyces cerevisiae YOL141W PPM2 AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p; tRNA methyltransferase PPM2 184190 34688316 LALA0_S13e02168g Lachancea lanzarotensis tRNA methyltransferase PPM2 XP_022630954.1 182181 D 1245769 CDS LALA0_S13e02190g 34688317 complement(184240..185715) Unknown 1 NW_019212891.1 similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C (ohnolog of YJR015W) SNG1 Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance; uncharacterized protein 185715 34688317 LALA0_S13e02190g Lachancea lanzarotensis uncharacterized protein XP_022630955.1 184240 R 1245769 CDS LALA0_S13e02212g 34688318 187158..188399 Unknown 1 NW_019212891.1 similar to uniprot|P42838 Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; uncharacterized protein 188399 34688318 LALA0_S13e02212g Lachancea lanzarotensis uncharacterized protein XP_022630956.1 187158 D 1245769 CDS LALA0_S13e02234g 34688319 188642..189916 Unknown 1 NW_019212891.1 highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; acetylornithine transaminase 189916 34688319 LALA0_S13e02234g Lachancea lanzarotensis acetylornithine transaminase XP_022630957.1 188642 D 1245769 CDS LALA0_S13e02256g 34688320 complement(190010..190876) Unknown 1 NW_019212891.1 similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor; uncharacterized protein 190876 34688320 LALA0_S13e02256g Lachancea lanzarotensis uncharacterized protein XP_022630958.1 190010 R 1245769 CDS LALA0_S13e02278g 34688321 193393..195843 Unknown 1 NW_019212891.1 similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W VNX1 Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; uncharacterized protein 195843 34688321 LALA0_S13e02278g Lachancea lanzarotensis uncharacterized protein XP_022630959.1 193393 D 1245769 CDS LALA0_S13e02300g 34688322 complement(195955..196584) Unknown 1 NW_019212891.1 similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); translation initiation factor eIF4E 196584 34688322 LALA0_S13e02300g Lachancea lanzarotensis translation initiation factor eIF4E XP_022630960.1 195955 R 1245769 CDS LALA0_S13e02322g 34688323 198686..199534 Unknown 1 NW_019212891.1 similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 199534 34688323 LALA0_S13e02322g Lachancea lanzarotensis uncharacterized protein XP_022630961.1 198686 D 1245769 CDS LALA0_S13e02344g 34688324 complement(199556..203413) Unknown 1 NW_019212891.1 similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C RTC1 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif; uncharacterized protein 203413 34688324 LALA0_S13e02344g Lachancea lanzarotensis uncharacterized protein XP_022630962.1 199556 R 1245769 CDS LALA0_S13e02366g 34688325 complement(203803..205770) Unknown 1 NW_019212891.1 similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p; coiled-coil domain-containing protein MAD1 205770 34688325 LALA0_S13e02366g Lachancea lanzarotensis coiled-coil domain-containing protein MAD1 XP_022630963.1 203803 R 1245769 CDS LALA0_S13e02388g 34688326 join(206022..206032,206100..206505) Unknown 1 NW_019212891.1 highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; E2 ubiquitin-conjugating protein MMS2 206505 34688326 LALA0_S13e02388g Lachancea lanzarotensis E2 ubiquitin-conjugating protein MMS2 XP_022630964.1 206022 D 1245769 CDS LALA0_S13e02410g 34688327 206943..208196 Unknown 1 NW_019212891.1 highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress; NADH kinase 208196 34688327 LALA0_S13e02410g Lachancea lanzarotensis NADH kinase XP_022630965.1 206943 D 1245769 CDS LALA0_S13e02432g 34688328 complement(208943..210277) Unknown 1 NW_019212891.1 weakly similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; uncharacterized protein 210277 34688328 LALA0_S13e02432g Lachancea lanzarotensis uncharacterized protein XP_022630966.1 208943 R 1245769 CDS LALA0_S13e02454g 34688329 <211665..>212270 Unknown 1 NW_019212891.1 similar to uniprot|P32435 Saccharomyces cerevisiae YGL089C (ohnolog of YPL187W) MF(ALPHA)2 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2; uncharacterized protein 212270 34688329 LALA0_S13e02454g Lachancea lanzarotensis uncharacterized protein XP_022630967.1 211665 D 1245769 CDS LALA0_S13e02476g 34688330 complement(212676..213386) Unknown 1 NW_019212891.1 weakly similar to uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope; uncharacterized protein 213386 34688330 LALA0_S13e02476g Lachancea lanzarotensis uncharacterized protein XP_022630968.1 212676 R 1245769 CDS LALA0_S13e02498g 34688331 complement(215286..216992) Unknown 1 NW_019212891.1 similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C MRN1 RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); uncharacterized protein 216992 34688331 LALA0_S13e02498g Lachancea lanzarotensis uncharacterized protein XP_022630969.1 215286 R 1245769 CDS LALA0_S13e02520g 34688332 complement(217558..218841) Unknown 1 NW_019212891.1 weakly similar to uniprot|P53150 Saccharomyces cerevisiae YGL090W LIF1 Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein; uncharacterized protein 218841 34688332 LALA0_S13e02520g Lachancea lanzarotensis uncharacterized protein XP_022630970.1 217558 R 1245769 CDS LALA0_S13e02542g 34688333 219620..220594 Unknown 1 NW_019212891.1 highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases; Fe-S cluster-binding ATPase 220594 34688333 LALA0_S13e02542g Lachancea lanzarotensis Fe-S cluster-binding ATPase XP_022630971.1 219620 D 1245769 CDS LALA0_S13e02564g 34688334 complement(220675..224556) Unknown 1 NW_019212891.1 weakly similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin, subunit of the Nup84p subcomplex; catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p; the Nup84 subcomplex has a role in transcription elongation; nucleocytoplasmic transporter NUP145 224556 34688334 LALA0_S13e02564g Lachancea lanzarotensis nucleocytoplasmic transporter NUP145 XP_022630972.1 220675 R 1245769 CDS LALA0_S13e02586g 34688335 complement(224931..227498) Unknown 1 NW_019212891.1 weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; uncharacterized protein 227498 34688335 LALA0_S13e02586g Lachancea lanzarotensis uncharacterized protein XP_022630973.1 224931 R 1245769 CDS LALA0_S13e02608g 34688336 join(227719..227871,227940..228011) Unknown 1 NW_019212891.1 similar to uniprot|O14464 Saccharomyces cerevisiae YPL183W-A RTC6 Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus; mitochondrial 54S ribosomal protein bL36m 228011 34688336 LALA0_S13e02608g Lachancea lanzarotensis mitochondrial 54S ribosomal protein bL36m XP_022630974.1 227719 D 1245769 CDS LALA0_S13e02630g 34688337 complement(228218..231214) Unknown 1 NW_019212891.1 similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C RTT10 Cytoplasmic protein with a role in regulation of Ty1 transposition; uncharacterized protein 231214 34688337 LALA0_S13e02630g Lachancea lanzarotensis uncharacterized protein XP_022630975.1 228218 R 1245769 CDS LALA0_S13e02652g 34688338 231590..234979 Unknown 1 NW_019212891.1 similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; poly(A)-specific ribonuclease 234979 34688338 LALA0_S13e02652g Lachancea lanzarotensis poly(A)-specific ribonuclease XP_022630976.1 231590 D 1245769 CDS LALA0_S13e02674g 34688339 complement(235119..237257) Unknown 1 NW_019212891.1 weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin; uncharacterized protein 237257 34688339 LALA0_S13e02674g Lachancea lanzarotensis uncharacterized protein XP_022630977.1 235119 R 1245769 CDS LALA0_S13e02696g 34688340 239558..241294 Unknown 1 NW_019212891.1 similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; uncharacterized protein 241294 34688340 LALA0_S13e02696g Lachancea lanzarotensis uncharacterized protein XP_022630978.1 239558 D 1245769 CDS LALA0_S13e02718g 34688341 complement(241317..242825) Unknown 1 NW_019212891.1 weakly similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain; uncharacterized protein 242825 34688341 LALA0_S13e02718g Lachancea lanzarotensis uncharacterized protein XP_022630979.1 241317 R 1245769 CDS LALA0_S13e02740g 34688342 244389..246020 Unknown 1 NW_019212891.1 similar to uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors; protein-serine/threonine phosphatase 246020 34688342 LALA0_S13e02740g Lachancea lanzarotensis protein-serine/threonine phosphatase XP_022630980.1 244389 D 1245769 CDS LALA0_S13e02784g 34688344 246663..247277 Unknown 1 NW_019212891.1 highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif; nuclear cap-binding protein subunit CBC2 247277 34688344 LALA0_S13e02784g Lachancea lanzarotensis nuclear cap-binding protein subunit CBC2 XP_022630981.1 246663 D 1245769 CDS LALA0_S13e02806g 34688345 complement(247524..248270) Unknown 1 NW_019212891.1 weakly similar to uniprot|P53147 Saccharomyces cerevisiae YGL096W (ohnolog of YPL177C) TOS8 Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor; 248270 34688345 LALA0_S13e02806g Lachancea lanzarotensis 247524 R 1245769 CDS LALA0_S13e02828g 34688346 249482..249988 Unknown 1 NW_019212891.1 hypothetical protein; uncharacterized protein 249988 34688346 LALA0_S13e02828g Lachancea lanzarotensis uncharacterized protein XP_022630982.1 249482 D 1245769 CDS LALA0_S13e02850g 34688347 250701..252098 Unknown 1 NW_019212891.1 weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W SPO23 Protein of unknown function; associates with meiosis-specific protein Spo1p; uncharacterized protein 252098 34688347 LALA0_S13e02850g Lachancea lanzarotensis uncharacterized protein XP_022630983.1 250701 D 1245769 CDS LALA0_S13e02872g 34688348 complement(252409..254229) Unknown 1 NW_019212891.1 similar to uniprot|P38156 Saccharomyces cerevisiae YBR298C MAL31 Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; uncharacterized protein 254229 34688348 LALA0_S13e02872g Lachancea lanzarotensis uncharacterized protein XP_022630984.1 252409 R 1245769 CDS LALA0_S13e02894g 34688349 257307..259085 Unknown 1 NW_019212891.1 similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C IMA1 Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family; uncharacterized protein 259085 34688349 LALA0_S13e02894g Lachancea lanzarotensis uncharacterized protein XP_022630985.1 257307 D 1245769 CDS LALA0_S13e02916g 34688350 259718..260818 Unknown 1 NW_019212891.1 highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; 3-deoxy-7-phosphoheptulonate synthase ARO4 260818 34688350 LALA0_S13e02916g Lachancea lanzarotensis 3-deoxy-7-phosphoheptulonate synthase ARO4 XP_022630986.1 259718 D 1245769 CDS LALA0_S13e02938g 34688351 261486..263132 Unknown 1 NW_019212891.1 highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor; imidazoleglycerol-phosphate synthase 263132 34688351 LALA0_S13e02938g Lachancea lanzarotensis imidazoleglycerol-phosphate synthase XP_022630987.1 261486 D 1245769 CDS LALA0_S13e02960g 34688352 complement(263339..264784) Unknown 1 NW_019212891.1 highly similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; Ran guanyl-nucleotide exchange factor 264784 34688352 LALA0_S13e02960g Lachancea lanzarotensis Ran guanyl-nucleotide exchange factor XP_022630988.1 263339 R 1245769 CDS LALA0_S13e02982g 34688353 265215..266075 Unknown 1 NW_019212891.1 similar to uniprot|C5E2J1 Lachancea thermotolerans KLTH0H05412g hypothetical protein; uncharacterized protein 266075 34688353 LALA0_S13e02982g Lachancea lanzarotensis uncharacterized protein XP_022630989.1 265215 D 1245769 CDS LALA0_S13e03004g 34688354 266312..267745 Unknown 1 NW_019212891.1 highly similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; snoRNA-binding rRNA-processing protein ENP1 267745 34688354 LALA0_S13e03004g Lachancea lanzarotensis snoRNA-binding rRNA-processing protein ENP1 XP_022630990.1 266312 D 1245769 CDS LALA0_S13e03026g 34688355 complement(268453..269274) Unknown 1 NW_019212891.1 similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p; SNAP receptor USE1 269274 34688355 LALA0_S13e03026g Lachancea lanzarotensis SNAP receptor USE1 XP_022630991.1 268453 R 1245769 CDS LALA0_S13e03048g 34688356 complement(270493..272412) Unknown 1 NW_019212891.1 highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; uncharacterized protein 272412 34688356 LALA0_S13e03048g Lachancea lanzarotensis uncharacterized protein XP_022630992.1 270493 R 1245769 CDS LALA0_S13e03070g 34688357 complement(272705..273844) Unknown 1 NW_019212891.1 similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W RRT2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype; diphthamide synthase 273844 34688357 LALA0_S13e03070g Lachancea lanzarotensis diphthamide synthase XP_022630993.1 272705 R 1245769 CDS LALA0_S13e03092g 34688358 274111..277323 Unknown 1 NW_019212891.1 similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation; chromatin-remodeling ATPase ISW1 277323 34688358 LALA0_S13e03092g Lachancea lanzarotensis chromatin-remodeling ATPase ISW1 XP_022630994.1 274111 D 1245769 CDS LALA0_S13e03114g 34688359 complement(277525..278088) Unknown 1 NW_019212891.1 similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W (ohnolog of YKL026C) HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; glutathione peroxidase GPX2 278088 34688359 LALA0_S13e03114g Lachancea lanzarotensis glutathione peroxidase GPX2 XP_022630995.1 277525 R 1245769 CDS LALA0_S13e03136g 34688360 join(280974..281237,281240..281626,281628..282149,282151..282270,282270..282473) Unknown 1 NW_019212891.1 putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate; 282473 34688360 LALA0_S13e03136g Lachancea lanzarotensis 280974 D 1245769 CDS LALA0_S13e03158g 34688361 complement(283524..284543) Unknown 1 NW_019212891.1 highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein of the conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); part of the SEA (Seh1-associated) complex, a coatamer-related complex that associates dynamically with the vacuole; homologous to Sec13p; the Nup84 subcomplex has a role in transcription elongation; uncharacterized protein 284543 34688361 LALA0_S13e03158g Lachancea lanzarotensis uncharacterized protein XP_022630996.1 283524 R 1245769 CDS LALA0_S13e03180g 34688362 284751..286097 Unknown 1 NW_019212891.1 highly similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 286097 34688362 LALA0_S13e03180g Lachancea lanzarotensis UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase XP_022630997.1 284751 D 1245769 CDS LALA0_S13e03202g 34688363 complement(286207..286929) Unknown 1 NW_019212891.1 similar to uniprot|P53144 Saccharomyces cerevisiae YGL101W (ohnolog of YBR242W) Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p; 5'-deoxynucleotidase 286929 34688363 LALA0_S13e03202g Lachancea lanzarotensis 5'-deoxynucleotidase XP_022630998.1 286207 R 1245769 CDS LALA0_S13e03224g 34688364 complement(join(287196..287596,288020..288068)) Unknown 1 NW_019212891.1 highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance; 60S ribosomal protein uL15 288068 34688364 LALA0_S13e03224g Lachancea lanzarotensis 60S ribosomal protein uL15 XP_022630999.1 287196 R 1245769 CDS LALA0_S13e03246g 34688365 289152..290663 Unknown 1 NW_019212891.1 similar to uniprot|P53142 Saccharomyces cerevisiae YGL104C (ohnolog of YBR241C) VPS73 Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; uncharacterized protein 290663 34688365 LALA0_S13e03246g Lachancea lanzarotensis uncharacterized protein XP_022631000.1 289152 D 1245769 CDS LALA0_S13e03268g 34688366 291085..292455 Unknown 1 NW_019212891.1 weakly similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes; uncharacterized protein 292455 34688366 LALA0_S13e03268g Lachancea lanzarotensis uncharacterized protein XP_022631001.1 291085 D 1245769 CDS LALA0_S13e03290g 34688367 complement(292547..293668) Unknown 1 NW_019212891.1 similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; uncharacterized protein 293668 34688367 LALA0_S13e03290g Lachancea lanzarotensis uncharacterized protein XP_022631002.1 292547 R 1245769 CDS LALA0_S13e03312g 34688368 294571..295977 Unknown 1 NW_019212891.1 similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C ERT1 Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; uncharacterized protein 295977 34688368 LALA0_S13e03312g Lachancea lanzarotensis uncharacterized protein XP_022631003.1 294571 D 1245769 CDS LALA0_S13e03334g 34688369 complement(296108..296539) Unknown 1 NW_019212891.1 highly similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition; uncharacterized protein 296539 34688369 LALA0_S13e03334g Lachancea lanzarotensis uncharacterized protein XP_022631004.1 296108 R 1245769 CDS LALA0_S13e03356g 34688370 298346..300325 Unknown 1 NW_019212891.1 similar to uniprot|P53140 Saccharomyces cerevisiae YGL107C (ohnolog of YBR238C) RMD9 Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; uncharacterized protein 300325 34688370 LALA0_S13e03356g Lachancea lanzarotensis uncharacterized protein XP_022631005.1 298346 D 1245769 CDS LALA0_S13e03378g 34688371 300601..300984 Unknown 1 NW_019212891.1 similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 300984 34688371 LALA0_S13e03378g Lachancea lanzarotensis uncharacterized protein XP_022631006.1 300601 D 1245769 CDS LALA0_S13e03400g 34688372 complement(301087..303630) Unknown 1 NW_019212891.1 similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA; DEAD-box RNA helicase PRP5 303630 34688372 LALA0_S13e03400g Lachancea lanzarotensis DEAD-box RNA helicase PRP5 XP_022631007.1 301087 R 1245769 CDS LALA0_S13e03422g 34688373 303796..305061 Unknown 1 NW_019212891.1 highly similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; mRNA (guanine-N7)-methyltransferase 305061 34688373 LALA0_S13e03422g Lachancea lanzarotensis mRNA (guanine-N7)-methyltransferase XP_022631008.1 303796 D 1245769 CDS LALA0_S13e03444g 34688374 complement(305091..308477) Unknown 1 NW_019212891.1 similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; uncharacterized protein 308477 34688374 LALA0_S13e03444g Lachancea lanzarotensis uncharacterized protein XP_022631009.1 305091 R 1245769 CDS LALA0_S13e03466g 34688375 308843..310612 Unknown 1 NW_019212891.1 similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; uncharacterized protein 310612 34688375 LALA0_S13e03466g Lachancea lanzarotensis uncharacterized protein XP_022631010.1 308843 D 1245769 CDS LALA0_S13e03488g 34688376 complement(310676..311998) Unknown 1 NW_019212891.1 similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; 311998 34688376 LALA0_S13e03488g Lachancea lanzarotensis 310676 R 1245769 CDS LALA0_S13e03510g 34688377 312843..313967 Unknown 1 NW_019212891.1 highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; uncharacterized protein 313967 34688377 LALA0_S13e03510g Lachancea lanzarotensis uncharacterized protein XP_022631011.1 312843 D 1245769 CDS LALA0_S13e03532g 34688378 complement(314027..314287) Unknown 1 NW_019212891.1 similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; uncharacterized protein 314287 34688378 LALA0_S13e03532g Lachancea lanzarotensis uncharacterized protein XP_022631012.1 314027 R 1245769 CDS LALA0_S13e03554g 34688379 315404..316936 Unknown 1 NW_019212891.1 highly similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; TATA-binding protein-associated factor TAF6 316936 34688379 LALA0_S13e03554g Lachancea lanzarotensis TATA-binding protein-associated factor TAF6 XP_022631013.1 315404 D 1245769 CDS LALA0_S13e03576g 34688380 complement(317021..319165) Unknown 1 NW_019212891.1 weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; uncharacterized protein 319165 34688380 LALA0_S13e03576g Lachancea lanzarotensis uncharacterized protein XP_022631014.1 317021 R 1245769 CDS LALA0_S13e03598g 34688381 complement(319362..320759) Unknown 1 NW_019212891.1 similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W PBP2 RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; uncharacterized protein 320759 34688381 LALA0_S13e03598g Lachancea lanzarotensis uncharacterized protein XP_022631015.1 319362 R 1245769 CDS LALA0_S13e03620g 34688382 320989..321867 Unknown 1 NW_019212891.1 similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; uncharacterized protein 321867 34688382 LALA0_S13e03620g Lachancea lanzarotensis uncharacterized protein XP_022631016.1 320989 D 1245769 CDS LALA0_S13e03642g 34688383 complement(321920..324106) Unknown 1 NW_019212891.1 similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters; uncharacterized protein 324106 34688383 LALA0_S13e03642g Lachancea lanzarotensis uncharacterized protein XP_022631017.1 321920 R 1245769 CDS LALA0_S13e03664g 34688384 complement(324767..325717) Unknown 1 NW_019212891.1 highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 325717 34688384 LALA0_S13e03664g Lachancea lanzarotensis AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 XP_022631018.1 324767 R 1245769 CDS LALA0_S13e03708g 34688386 complement(326796..328526) Unknown 1 NW_019212891.1 similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate; ubiquitin-protein transferase activating protein CDC20 328526 34688386 LALA0_S13e03708g Lachancea lanzarotensis ubiquitin-protein transferase activating protein CDC20 XP_022631019.1 326796 R 1245769 CDS LALA0_S13e03730g 34688387 complement(329018..330268) Unknown 1 NW_019212891.1 highly similar to uniprot|C5DIA2 Lachancea thermotolerans KLTH0E10912g hypothetical protein; uncharacterized protein 330268 34688387 LALA0_S13e03730g Lachancea lanzarotensis uncharacterized protein XP_022631020.1 329018 R 1245769 CDS LALA0_S13e03752g 34688388 complement(331017..331805) Unknown 1 NW_019212891.1 similar to uniprot|C5DC79 Lachancea thermotolerans KLTH0B00836g hypothetical protein; uncharacterized protein 331805 34688388 LALA0_S13e03752g Lachancea lanzarotensis uncharacterized protein XP_022631021.1 331017 R 1245769 CDS LALA0_S13e03796g 34688390 complement(join(332553..333881,333956..334288)) Unknown 1 NW_019212891.1 similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W (ohnolog of YBR230W-A) COQ8 Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; protein kinase COQ8 334288 34688390 LALA0_S13e03796g Lachancea lanzarotensis protein kinase COQ8 XP_022631022.1 332553 R 1245769 CDS LALA0_S13e03818g 34688391 335289..337601 Unknown 1 NW_019212891.1 highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; DEAH-box ATP-dependent RNA helicase PRP43 337601 34688391 LALA0_S13e03818g Lachancea lanzarotensis DEAH-box ATP-dependent RNA helicase PRP43 XP_022631023.1 335289 D 1245769 CDS LALA0_S14e00100g 34688392 996..2102 Unknown 1 NW_019212892.1 similar to uniprot|I6NCR2 Eremothecium cymbalariae Ecym_5064 hypothetical protein; uncharacterized protein 2102 34688392 LALA0_S14e00100g Lachancea lanzarotensis uncharacterized protein XP_022631024.1 996 D 1245769 CDS LALA0_S14e00122g 34688393 join(2373..2383,2455..2543,2622..3349) Unknown 1 NW_019212892.1 similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W SAW1 Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; DNA-binding protein SAW1 3349 34688393 LALA0_S14e00122g Lachancea lanzarotensis DNA-binding protein SAW1 XP_022631025.1 2373 D 1245769 CDS LALA0_S14e00144g 34688394 3582..4955 Unknown 1 NW_019212892.1 highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis; glutamate-5-semialdehyde dehydrogenase 4955 34688394 LALA0_S14e00144g Lachancea lanzarotensis glutamate-5-semialdehyde dehydrogenase XP_022631026.1 3582 D 1245769 CDS LALA0_S14e00166g 34688395 complement(5041..8988) Unknown 1 NW_019212892.1 similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease; aminophospholipid-translocating P4-type ATPase DRS2 8988 34688395 LALA0_S14e00166g Lachancea lanzarotensis aminophospholipid-translocating P4-type ATPase DRS2 XP_022631027.1 5041 R 1245769 CDS LALA0_S14e00188g 34688396 complement(9396..10319) Unknown 1 NW_019212892.1 highly similar to uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus; ribosome biosynthesis protein MAK16 10319 34688396 LALA0_S14e00188g Lachancea lanzarotensis ribosome biosynthesis protein MAK16 XP_022631028.1 9396 R 1245769 CDS LALA0_S14e00210g 34688397 complement(10682..14842) Unknown 1 NW_019212892.1 similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures; mitotic regulator LTE1 14842 34688397 LALA0_S14e00210g Lachancea lanzarotensis mitotic regulator LTE1 XP_022631029.1 10682 R 1245769 CDS LALA0_S14e00232g 34688398 complement(15854..17881) Unknown 1 NW_019212892.1 weakly similar to uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency; uncharacterized protein 17881 34688398 LALA0_S14e00232g Lachancea lanzarotensis uncharacterized protein XP_022631030.1 15854 R 1245769 CDS LALA0_S14e00254g 34688399 18127..18894 Unknown 1 NW_019212892.1 weakly similar to uniprot|Q01090 Lachancea waltii pKW1_04 hypothetical protein; uncharacterized protein 18894 34688399 LALA0_S14e00254g Lachancea lanzarotensis uncharacterized protein XP_022631031.1 18127 D 1245769 CDS LALA0_S14e00276g 34688400 complement(18908..22519) Unknown 1 NW_019212892.1 similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases; DNA-directed DNA polymerase gamma MIP1 22519 34688400 LALA0_S14e00276g Lachancea lanzarotensis DNA-directed DNA polymerase gamma MIP1 XP_022631032.1 18908 R 1245769 CDS LALA0_S14e00298g 34688401 26066..26758 Unknown 1 NW_019212892.1 highly similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; H(+)-transporting V1 sector ATPase subunit E 26758 34688401 LALA0_S14e00298g Lachancea lanzarotensis H(+)-transporting V1 sector ATPase subunit E XP_022631033.1 26066 D 1245769 CDS LALA0_S14e00320g 34688402 27099..28373 Unknown 1 NW_019212892.1 similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; uncharacterized protein 28373 34688402 LALA0_S14e00320g Lachancea lanzarotensis uncharacterized protein XP_022631034.1 27099 D 1245769 CDS LALA0_S14e00342g 34688403 28684..31152 Unknown 1 NW_019212892.1 weakly similar to uniprot|P39732 Saccharomyces cerevisiae YAL031C GIP4 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate; protein phosphatase regulator GIP4 31152 34688403 LALA0_S14e00342g Lachancea lanzarotensis protein phosphatase regulator GIP4 XP_022631035.1 28684 D 1245769 CDS LALA0_S14e00364g 34688404 31615..32994 Unknown 1 NW_019212892.1 similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene; mRNA splicing protein PRP45 32994 34688404 LALA0_S14e00364g Lachancea lanzarotensis mRNA splicing protein PRP45 XP_022631036.1 31615 D 1245769 CDS LALA0_S14e00386g 34688405 complement(33090..33578) Unknown 1 NW_019212892.1 similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; RNA-binding protein POP5 33578 34688405 LALA0_S14e00386g Lachancea lanzarotensis RNA-binding protein POP5 XP_022631037.1 33090 R 1245769 CDS LALA0_S14e00408g 34688406 complement(33832..36693) Unknown 1 NW_019212892.1 highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; alanine--tRNA ligase 36693 34688406 LALA0_S14e00408g Lachancea lanzarotensis alanine--tRNA ligase XP_022631038.1 33832 R 1245769 CDS LALA0_S14e00430g 34688407 38127..42098 Unknown 1 NW_019212892.1 similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; uncharacterized protein 42098 34688407 LALA0_S14e00430g Lachancea lanzarotensis uncharacterized protein XP_022631039.1 38127 D 1245769 CDS LALA0_S14e00452g 34688408 42508..44502 Unknown 1 NW_019212892.1 similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein; uncharacterized protein 44502 34688408 LALA0_S14e00452g Lachancea lanzarotensis uncharacterized protein XP_022631040.1 42508 D 1245769 CDS LALA0_S14e00474g 34688409 complement(join(45105..45161,45161..45451,45453..45752)) Unknown 1 NW_019212892.1 weakly similar to uniprot|Q01090 Lachancea waltii pKW1_04 hypothetical protein; 45752 34688409 LALA0_S14e00474g Lachancea lanzarotensis 45105 R 1245769 CDS LALA0_S14e00496g 34688410 46027..46509 Unknown 1 NW_019212892.1 hypothetical protein; uncharacterized protein 46509 34688410 LALA0_S14e00496g Lachancea lanzarotensis uncharacterized protein XP_022631041.1 46027 D 1245769 CDS LALA0_S14e00518g 34688411 46792..47865 Unknown 1 NW_019212892.1 similar to uniprot|O13515 Saccharomyces cerevisiae YAL034C (ohnolog of YOR338W) FUN19 Non-essential protein of unknown function; expression induced in response to heat stress; uncharacterized protein 47865 34688411 LALA0_S14e00518g Lachancea lanzarotensis uncharacterized protein XP_022631042.1 46792 D 1245769 CDS LALA0_S14e00540g 34688412 complement(48192..48677) Unknown 1 NW_019212892.1 similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C UBC11 Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2; uncharacterized protein 48677 34688412 LALA0_S14e00540g Lachancea lanzarotensis uncharacterized protein XP_022631043.1 48192 R 1245769 CDS LALA0_S14e00562g 34688413 complement(48930..49835) Unknown 1 NW_019212892.1 similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; MIND complex subunit MTW1 49835 34688413 LALA0_S14e00562g Lachancea lanzarotensis MIND complex subunit MTW1 XP_022631044.1 48930 R 1245769 CDS LALA0_S14e00584g 34688414 complement(50278..51177) Unknown 1 NW_019212892.1 similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43; DNA-directed RNA polymerase I subunit RPA43 51177 34688414 LALA0_S14e00584g Lachancea lanzarotensis DNA-directed RNA polymerase I subunit RPA43 XP_022631045.1 50278 R 1245769 CDS LALA0_S14e00606g 34688415 complement(51890..52081) Unknown 1 NW_019212892.1 highly similar to uniprot|G8BZN7 Tetrapisispora phaffii TPHA0K02350 hypothetical protein; uncharacterized protein 52081 34688415 LALA0_S14e00606g Lachancea lanzarotensis uncharacterized protein XP_022631046.1 51890 R 1245769 CDS LALA0_S14e00628g 34688416 53010..57983 Unknown 1 NW_019212892.1 highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I largest subunit A190; DNA-directed RNA polymerase I core subunit RPA190 57983 34688416 LALA0_S14e00628g Lachancea lanzarotensis DNA-directed RNA polymerase I core subunit RPA190 XP_022631047.1 53010 D 1245769 CDS LALA0_S14e00650g 34688417 complement(58266..61244) Unknown 1 NW_019212892.1 highly similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2; translation initiation factor eIF5B 61244 34688417 LALA0_S14e00650g Lachancea lanzarotensis translation initiation factor eIF5B XP_022631048.1 58266 R 1245769 CDS LALA0_S14e00672g 34688418 62401..63186 Unknown 1 NW_019212892.1 weakly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein; uncharacterized protein 63186 34688418 LALA0_S14e00672g Lachancea lanzarotensis uncharacterized protein XP_022631049.1 62401 D 1245769 CDS LALA0_S14e00694g 34688419 64058..65167 Unknown 1 NW_019212892.1 highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; GTP-binding protein RBG1 65167 34688419 LALA0_S14e00694g Lachancea lanzarotensis GTP-binding protein RBG1 XP_022631050.1 64058 D 1245769 CDS LALA0_S14e00716g 34688420 complement(65353..66300) Unknown 1 NW_019212892.1 weakly similar to uniprot|P39728 Saccharomyces cerevisiae YAL037W (ohnolog of YOR342C) Putative protein of unknown function; uncharacterized protein 66300 34688420 LALA0_S14e00716g Lachancea lanzarotensis uncharacterized protein XP_022631051.1 65353 R 1245769 CDS LALA0_S14e00738g 34688421 complement(66808..67833) Unknown 1 NW_019212892.1 weakly similar to uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; uncharacterized protein 67833 34688421 LALA0_S14e00738g Lachancea lanzarotensis uncharacterized protein XP_022631052.1 66808 R 1245769 CDS LALA0_S14e00760g 34688422 69464..72424 Unknown 1 NW_019212892.1 similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; deoxycytidyl transferase 72424 34688422 LALA0_S14e00760g Lachancea lanzarotensis deoxycytidyl transferase XP_022631053.1 69464 D 1245769 CDS LALA0_S14e00782g 34688423 complement(72548..74053) Unknown 1 NW_019212892.1 highly similar to uniprot|P00549 Saccharomyces cerevisiae YAL038W (ohnolog of YOR347C) CDC19 Pyruvatekinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, the input foraerobic (TCA cycle) or anaerobic (glucose fermentation)respiration; pyruvate kinase PYK2 74053 34688423 LALA0_S14e00782g Lachancea lanzarotensis pyruvate kinase PYK2 XP_022631054.1 72548 R 1245769 CDS LALA0_S14e00804g 34688424 75639..78650 Unknown 1 NW_019212892.1 weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; uncharacterized protein 78650 34688424 LALA0_S14e00804g Lachancea lanzarotensis uncharacterized protein XP_022631055.1 75639 D 1245769 CDS LALA0_S14e00826g 34688425 complement(78713..80596) Unknown 1 NW_019212892.1 weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C MNE1 Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA; uncharacterized protein 80596 34688425 LALA0_S14e00826g Lachancea lanzarotensis uncharacterized protein XP_022631056.1 78713 R 1245769 CDS LALA0_S14e00848g 34688426 complement(join(80900..81739,81800..82411)) Unknown 1 NW_019212892.1 similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; serine/threonine protein kinase MEK1 82411 34688426 LALA0_S14e00848g Lachancea lanzarotensis serine/threonine protein kinase MEK1 XP_022631057.1 80900 R 1245769 CDS LALA0_S14e00870g 34688427 83168..84064 Unknown 1 NW_019212892.1 similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; TFIIH complex subunit TFB6 84064 34688427 LALA0_S14e00870g Lachancea lanzarotensis TFIIH complex subunit TFB6 XP_022631058.1 83168 D 1245769 CDS LALA0_S14e00892g 34688428 complement(84093..86255) Unknown 1 NW_019212892.1 similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis; uncharacterized protein 86255 34688428 LALA0_S14e00892g Lachancea lanzarotensis uncharacterized protein XP_022631059.1 84093 R 1245769 CDS LALA0_S14e00914g 34688429 join(87223..87252,87324..88127) Unknown 1 NW_019212892.1 similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); holocytochrome c synthase CYC3 88127 34688429 LALA0_S14e00914g Lachancea lanzarotensis holocytochrome c synthase CYC3 XP_022631060.1 87223 D 1245769 CDS LALA0_S14e00936g 34688430 complement(88312..90351) Unknown 1 NW_019212892.1 weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 90351 34688430 LALA0_S14e00936g Lachancea lanzarotensis uncharacterized protein XP_022631061.1 88312 R 1245769 CDS LALA0_S14e00958g 34688431 92081..95089 Unknown 1 NW_019212892.1 putative transposase of the Rover hAT-like DNA transposon 95089 34688431 LALA0_S14e00958g Lachancea lanzarotensis putative transposase of the Rover hAT-like DNA transposon XP_022631062.1 92081 D 1245769 CDS LALA0_S14e00980g 34688432 98632..99951 Unknown 1 NW_019212892.1 weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; cyclin CLN3 99951 34688432 LALA0_S14e00980g Lachancea lanzarotensis cyclin CLN3 XP_022631063.1 98632 D 1245769 CDS LALA0_S14e01002g 34688433 100720..102345 Unknown 1 NW_019212892.1 similar to uniprot|C5DFX2 Lachancea thermotolerans KLTH0D00660g hypothetical protein; uncharacterized protein 102345 34688433 LALA0_S14e01002g Lachancea lanzarotensis uncharacterized protein XP_022631064.1 100720 D 1245769 CDS LALA0_S14e01024g 34688434 103330..104661 Unknown 1 NW_019212892.1 similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 104661 34688434 LALA0_S14e01024g Lachancea lanzarotensis uncharacterized protein XP_022631065.1 103330 D 1245769 CDS LALA0_S14e01046g 34688435 105136..107121 Unknown 1 NW_019212892.1 similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W CIR2 Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; uncharacterized protein 107121 34688435 LALA0_S14e01046g Lachancea lanzarotensis uncharacterized protein XP_022631066.1 105136 D 1245769 CDS LALA0_S14e01068g 34688436 complement(107556..109799) Unknown 1 NW_019212892.1 similar to uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; Rho family guanine nucleotide exchange factor CDC24 109799 34688436 LALA0_S14e01068g Lachancea lanzarotensis Rho family guanine nucleotide exchange factor CDC24 XP_022631067.1 107556 R 1245769 CDS LALA0_S14e01090g 34688437 complement(110253..111458) Unknown 1 NW_019212892.1 highly similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport; uncharacterized protein 111458 34688437 LALA0_S14e01090g Lachancea lanzarotensis uncharacterized protein XP_022631068.1 110253 R 1245769 CDS LALA0_S14e01112g 34688438 complement(112873..113355) Unknown 1 NW_019212892.1 highly similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C SNX3 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p; uncharacterized protein 113355 34688438 LALA0_S14e01112g Lachancea lanzarotensis uncharacterized protein XP_022631069.1 112873 R 1245769 CDS LALA0_S14e01134g 34688439 113551..113967 Unknown 1 NW_019212892.1 some similarities with uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex; uncharacterized protein 113967 34688439 LALA0_S14e01134g Lachancea lanzarotensis uncharacterized protein XP_022631070.1 113551 D 1245769 CDS LALA0_S14e01156g 34688440 114845..117016 Unknown 1 NW_019212892.1 similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII; RNA-processing protein PTA1 117016 34688440 LALA0_S14e01156g Lachancea lanzarotensis RNA-processing protein PTA1 XP_022631071.1 114845 D 1245769 CDS LALA0_S14e01178g 34688441 117988..119121 Unknown 1 NW_019212892.1 similar to uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1 Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain; uncharacterized protein 119121 34688441 LALA0_S14e01178g Lachancea lanzarotensis uncharacterized protein XP_022631072.1 117988 D 1245769 CDS LALA0_S14e01200g 34688442 complement(119303..120841) Unknown 1 NW_019212892.1 similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon; 3',5'-cyclic-nucleotide phosphodiesterase PDE2 120841 34688442 LALA0_S14e01200g Lachancea lanzarotensis 3',5'-cyclic-nucleotide phosphodiesterase PDE2 XP_022631073.1 119303 R 1245769 CDS LALA0_S14e01222g 34688443 124321..124836 Unknown 1 NW_019212892.1 similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; glycine decarboxylase subunit H 124836 34688443 LALA0_S14e01222g Lachancea lanzarotensis glycine decarboxylase subunit H XP_022631074.1 124321 D 1245769 CDS LALA0_S14e01244g 34688444 complement(124989..125336) Unknown 1 NW_019212892.1 similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein; uncharacterized protein 125336 34688444 LALA0_S14e01244g Lachancea lanzarotensis uncharacterized protein XP_022631075.1 124989 R 1245769 CDS LALA0_S14e01266g 34688445 125505..125768 Unknown 1 NW_019212892.1 similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C AIM1 Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss; uncharacterized protein 125768 34688445 LALA0_S14e01266g Lachancea lanzarotensis uncharacterized protein XP_022631076.1 125505 D 1245769 CDS LALA0_S14e01288g 34688446 complement(125928..128126) Unknown 1 NW_019212892.1 similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; translation initiation factor eIF3 core subunit b 128126 34688446 LALA0_S14e01288g Lachancea lanzarotensis translation initiation factor eIF3 core subunit b XP_022631077.1 125928 R 1245769 CDS LALA0_S14e01310g 34688447 128545..130692 Unknown 1 NW_019212892.1 weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization; gamma-tubulin complex subunit SPC72 130692 34688447 LALA0_S14e01310g Lachancea lanzarotensis gamma-tubulin complex subunit SPC72 XP_022631078.1 128545 D 1245769 CDS LALA0_S14e01332g 34688448 complement(join(130784..131614,131720..131722)) Unknown 1 NW_019212892.1 highly similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 Alpha 7 subunit of the 20S proteasome; proteasome core particle subunit alpha 7 131722 34688448 LALA0_S14e01332g Lachancea lanzarotensis proteasome core particle subunit alpha 7 XP_022631079.1 130784 R 1245769 CDS LALA0_S14e01354g 34688449 133169..135163 Unknown 1 NW_019212892.1 highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death; ERMES complex Ca(2+)-binding regulatory GTPase GEM1 135163 34688449 LALA0_S14e01354g Lachancea lanzarotensis ERMES complex Ca(2+)-binding regulatory GTPase GEM1 XP_022631080.1 133169 D 1245769 CDS LALA0_S14e01376g 34688450 complement(135303..138179) Unknown 1 NW_019212892.1 weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 138179 34688450 LALA0_S14e01376g Lachancea lanzarotensis uncharacterized protein XP_022631081.1 135303 R 1245769 CDS LALA0_S14e01398g 34688451 complement(138789..141125) Unknown 1 NW_019212892.1 similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W (ohnolog of YOR365C) FLC2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; uncharacterized protein 141125 34688451 LALA0_S14e01398g Lachancea lanzarotensis uncharacterized protein XP_022631082.1 138789 R 1245769 CDS LALA0_S14e01420g 34688452 142134..142754 Unknown 1 NW_019212892.1 similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W SCP1 Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin; uncharacterized protein 142754 34688452 LALA0_S14e01420g Lachancea lanzarotensis uncharacterized protein XP_022631083.1 142134 D 1245769 CDS LALA0_S14e01442g 34688453 complement(142777..143211) Unknown 1 NW_019212892.1 weakly similar to uniprot|P39718 Saccharomyces cerevisiae YAL055W PEX22 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation; uncharacterized protein 143211 34688453 LALA0_S14e01442g Lachancea lanzarotensis uncharacterized protein XP_022631084.1 142777 R 1245769 CDS LALA0_S14e01464g 34688454 143731..144909 Unknown 1 NW_019212892.1 similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; uncharacterized protein 144909 34688454 LALA0_S14e01464g Lachancea lanzarotensis uncharacterized protein XP_022631085.1 143731 D 1245769 CDS LALA0_S14e01486g 34688455 complement(145064..145495) Unknown 1 NW_019212892.1 highly similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C RPS12 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12; 40S ribosomal protein eS12 145495 34688455 LALA0_S14e01486g Lachancea lanzarotensis 40S ribosomal protein eS12 XP_022631086.1 145064 R 1245769 CDS LALA0_S14e01508g 34688456 complement(146939..148771) Unknown 1 NW_019212892.1 highly similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; GTPase-activating protein MRS6 148771 34688456 LALA0_S14e01508g Lachancea lanzarotensis GTPase-activating protein MRS6 XP_022631087.1 146939 R 1245769 CDS LALA0_S14e01530g 34688457 complement(149280..151775) Unknown 1 NW_019212892.1 weakly similar to uniprot|P39717 Saccharomyces cerevisiae YAL056W (ohnolog of YOR371C) GPB2 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; uncharacterized protein 151775 34688457 LALA0_S14e01530g Lachancea lanzarotensis uncharacterized protein XP_022631088.1 149280 R 1245769 CDS LALA0_S14e01552g 34688458 complement(152367..153908) Unknown 1 NW_019212892.1 weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; uncharacterized protein 153908 34688458 LALA0_S14e01552g Lachancea lanzarotensis uncharacterized protein XP_022631089.1 152367 R 1245769 CDS LALA0_S14e01574g 34688459 155564..157729 Unknown 1 NW_019212892.1 weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque, required for exit from mitosis; uncharacterized protein 157729 34688459 LALA0_S14e01574g Lachancea lanzarotensis uncharacterized protein XP_022631090.1 155564 D 1245769 CDS LALA0_S14e01596g 34688460 159653..161221 Unknown 1 NW_019212892.1 highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; aldehyde dehydrogenase (NADP(+)) ALD4 161221 34688460 LALA0_S14e01596g Lachancea lanzarotensis aldehyde dehydrogenase (NADP(+)) ALD4 XP_022631091.1 159653 D 1245769 CDS LALA0_S14e01618g 34688461 complement(161698..162081) Unknown 1 NW_019212892.1 similar to uniprot|G0RUS3 Hypocrea jecorina TRIREDRAFT_69077 hypothetical protein; uncharacterized protein 162081 34688461 LALA0_S14e01618g Lachancea lanzarotensis uncharacterized protein XP_022631092.1 161698 R 1245769 CDS LALA0_S14e01640g 34688462 complement(162569..163120) Unknown 1 NW_019212892.1 similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm; uncharacterized protein 163120 34688462 LALA0_S14e01640g Lachancea lanzarotensis uncharacterized protein XP_022631093.1 162569 R 1245769 CDS LALA0_S14e01662g 34688463 complement(164882..166258) Unknown 1 NW_019212892.1 highly similar to uniprot|P39708 Saccharomyces cerevisiae YAL062W (ohnolog of YOR375C) GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; glutamate dehydrogenase (NADP(+)) GDH1 166258 34688463 LALA0_S14e01662g Lachancea lanzarotensis glutamate dehydrogenase (NADP(+)) GDH1 XP_022631094.1 164882 R 1245769 CDS LALA0_S14e01684g 34688464 complement(168398..169048) Unknown 1 NW_019212892.1 weakly similar to uniprot|P38195 Saccharomyces cerevisiae YBL043W (ohnolog of YJR115W) ECM13 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; uncharacterized protein 169048 34688464 LALA0_S14e01684g Lachancea lanzarotensis uncharacterized protein XP_022631095.1 168398 R 1245769 CDS LALA0_S14e01706g 34688465 complement(join(170074..171129,171129..171218)) Unknown 1 NW_019212892.1 similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway; 171218 34688465 LALA0_S14e01706g Lachancea lanzarotensis 170074 R 1245769 CDS LALA0_S14e01728g 34688466 complement(172189..173928) Unknown 1 NW_019212892.1 weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake; uncharacterized protein 173928 34688466 LALA0_S14e01728g Lachancea lanzarotensis uncharacterized protein XP_022631096.1 172189 R 1245769 CDS LALA0_S14e01750g 34688467 175025..177025 Unknown 1 NW_019212892.1 weakly similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion; 177025 34688467 LALA0_S14e01750g Lachancea lanzarotensis 175025 D 1245769 CDS LALA0_S14e01772g 34688468 177809..179101 Unknown 1 NW_019212892.1 similar to uniprot|C5DJ05 Lachancea thermotolerans KLTH0E16610g hypothetical protein; uncharacterized protein 179101 34688468 LALA0_S14e01772g Lachancea lanzarotensis uncharacterized protein XP_022631097.1 177809 D 1245769 CDS LALA0_S14e01794g 34688469 180200..181228 Unknown 1 NW_019212892.1 similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; aldo-keto reductase superfamily protein 181228 34688469 LALA0_S14e01794g Lachancea lanzarotensis aldo-keto reductase superfamily protein XP_022631098.1 180200 D 1245769 CDS LALA0_S14e01816g 34688470 183905..185575 Unknown 1 NW_019212892.1 similar to uniprot|P38358 Saccharomyces cerevisiae YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 185575 34688470 LALA0_S14e01816g Lachancea lanzarotensis uncharacterized protein XP_022631099.1 183905 D 1245769 CDS LALA0_S14e01838g 34688471 186678..188366 Unknown 1 NW_019212892.1 highly similar to uniprot|C5DCQ9 Lachancea thermotolerans KLTH0B05082g hypothetical protein; uncharacterized protein 188366 34688471 LALA0_S14e01838g Lachancea lanzarotensis uncharacterized protein XP_022631100.1 186678 D 1245769 CDS LALA0_S14e01860g 34688472 complement(188904..189620) Unknown 1 NW_019212892.1 similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Putative protein of unknown function; YIR042C is a non-essential gene; uncharacterized protein 189620 34688472 LALA0_S14e01860g Lachancea lanzarotensis uncharacterized protein XP_022631101.1 188904 R 1245769 CDS LALA0_S14e01882g 34688473 complement(191860..193089) Unknown 1 NW_019212892.1 similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; uncharacterized protein 193089 34688473 LALA0_S14e01882g Lachancea lanzarotensis uncharacterized protein XP_022631102.1 191860 R 1245769 CDS LALA0_S14e01904g 34688474 197087..197818 Unknown 1 NW_019212892.1 weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin; uncharacterized protein 197818 34688474 LALA0_S14e01904g Lachancea lanzarotensis uncharacterized protein XP_022631103.1 197087 D 1245769 CDS LALA0_S14e01926g 34688475 complement(199398..200366) Unknown 1 NW_019212892.1 some similarities with uniprot|P40447 Saccharomyces cerevisiae YIL164C NIT1 Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene; uncharacterized protein 200366 34688475 LALA0_S14e01926g Lachancea lanzarotensis uncharacterized protein XP_022631104.1 199398 R 1245769 CDS LALA0_S14e01948g 34688476 complement(201033..201929) Unknown 1 NW_019212892.1 similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; epoxide hydrolase 201929 34688476 LALA0_S14e01948g Lachancea lanzarotensis epoxide hydrolase XP_022631105.1 201033 R 1245769 CDS LALA0_S15e00100g 34688477 300..2519 Unknown 1 NW_019212893.1 weakly similar to uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP); uncharacterized protein 2519 34688477 LALA0_S15e00100g Lachancea lanzarotensis uncharacterized protein XP_022631106.1 300 D 1245769 CDS LALA0_S15e00122g 34688478 complement(2880..3986) Unknown 1 NW_019212893.1 similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase; uncharacterized protein 3986 34688478 LALA0_S15e00122g Lachancea lanzarotensis uncharacterized protein XP_022631107.1 2880 R 1245769 CDS LALA0_S15e00144g 34688479 4164..7313 Unknown 1 NW_019212893.1 similar to uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia; uncharacterized protein 7313 34688479 LALA0_S15e00144g Lachancea lanzarotensis uncharacterized protein XP_022631108.1 4164 D 1245769 CDS LALA0_S15e00166g 34688480 complement(7417..9546) Unknown 1 NW_019212893.1 similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; nucleoporin NUP2 9546 34688480 LALA0_S15e00166g Lachancea lanzarotensis nucleoporin NUP2 XP_022631109.1 7417 R 1245769 CDS LALA0_S15e00210g 34688482 10906..11229 Unknown 1 NW_019212893.1 highly similar to uniprot|Q3E792 Saccharomyces cerevisiae YGR027C (ohnolog of YLR333C) RPS25A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein; 40S ribosomal protein eS25 11229 34688482 LALA0_S15e00210g Lachancea lanzarotensis 40S ribosomal protein eS25 XP_022631110.1 10906 D 1245769 CDS LALA0_S15e00232g 34688483 complement(12291..13133) Unknown 1 NW_019212893.1 similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 13133 34688483 LALA0_S15e00232g Lachancea lanzarotensis uncharacterized protein XP_022631111.1 12291 R 1245769 CDS LALA0_S15e00254g 34688484 14395..15141 Unknown 1 NW_019212893.1 weakly similar to uniprot|P43600 Saccharomyces cerevisiae YFR020W Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; uncharacterized protein 15141 34688484 LALA0_S15e00254g Lachancea lanzarotensis uncharacterized protein XP_022631112.1 14395 D 1245769 CDS LALA0_S15e00276g 34688485 join(15395..15730,15730..15879,15879..16385,16385..16570,16570..16707) Unknown 1 NW_019212893.1 some similarities with uniprot|Q12491 Saccharomyces cerevisiae YBL100W-B TY2B-B Transposon Ty2-B Gag-Pol polyprotein; 16707 34688485 LALA0_S15e00276g Lachancea lanzarotensis 15395 D 1245769 CDS LALA0_S15e00298g 34688486 17500..17985 Unknown 1 NW_019212893.1 hypothetical protein; uncharacterized protein 17985 34688486 LALA0_S15e00298g Lachancea lanzarotensis uncharacterized protein XP_022631113.1 17500 D 1245769 CDS LALA0_S15e00320g 34688487 18220..18909 Unknown 1 NW_019212893.1 similar to uniprot|P32564 Saccharomyces cerevisiae YGR049W (ohnolog of YLR356W) SCM4 Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis; uncharacterized protein 18909 34688487 LALA0_S15e00320g Lachancea lanzarotensis uncharacterized protein XP_022631114.1 18220 D 1245769 CDS LALA0_S15e00342g 34688488 19821..21098 Unknown 1 NW_019212893.1 weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation; protein kinase FMP48 21098 34688488 LALA0_S15e00342g Lachancea lanzarotensis protein kinase FMP48 XP_022631115.1 19821 D 1245769 CDS LALA0_S15e00364g 34688489 complement(21495..22292) Unknown 1 NW_019212893.1 weakly similar to uniprot|P53234 Saccharomyces cerevisiae YGR053C Putative protein of unknown function; uncharacterized protein 22292 34688489 LALA0_S15e00364g Lachancea lanzarotensis uncharacterized protein XP_022631116.1 21495 R 1245769 CDS LALA0_S15e00386g 34688490 23685..25568 Unknown 1 NW_019212893.1 similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A; uncharacterized protein 25568 34688490 LALA0_S15e00386g Lachancea lanzarotensis uncharacterized protein XP_022631117.1 23685 D 1245769 CDS LALA0_S15e00408g 34688491 26084..26323 Unknown 1 NW_019212893.1 similar to uniprot|C5DNR7 Lachancea thermotolerans KLTH0G19272g hypothetical protein; uncharacterized protein 26323 34688491 LALA0_S15e00408g Lachancea lanzarotensis uncharacterized protein XP_022631118.1 26084 D 1245769 CDS LALA0_S15e00430g 34688492 complement(26369..27415) Unknown 1 NW_019212893.1 similar to uniprot|P43568 Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; cyclin-dependent protein kinase-activating kinase CAK1 27415 34688492 LALA0_S15e00430g Lachancea lanzarotensis cyclin-dependent protein kinase-activating kinase CAK1 XP_022631119.1 26369 R 1245769 CDS LALA0_S15e00452g 34688493 complement(27750..28835) Unknown 1 NW_019212893.1 similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; C-5 sterol desaturase 28835 34688493 LALA0_S15e00452g Lachancea lanzarotensis C-5 sterol desaturase XP_022631120.1 27750 R 1245769 CDS LALA0_S15e00474g 34688494 complement(29364..30182) Unknown 1 NW_019212893.1 similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator; uncharacterized protein 30182 34688494 LALA0_S15e00474g Lachancea lanzarotensis uncharacterized protein XP_022631121.1 29364 R 1245769 CDS LALA0_S15e00496g 34688495 31454..33292 Unknown 1 NW_019212893.1 similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters; SAGA complex subunit SPT8 33292 34688495 LALA0_S15e00496g Lachancea lanzarotensis SAGA complex subunit SPT8 XP_022631122.1 31454 D 1245769 CDS LALA0_S15e00518g 34688496 complement(33357..34907) Unknown 1 NW_019212893.1 weakly similar to uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; GTPase-activating protein GYP8 34907 34688496 LALA0_S15e00518g Lachancea lanzarotensis GTPase-activating protein GYP8 XP_022631123.1 33357 R 1245769 CDS LALA0_S15e00540g 34688497 complement(36954..37787) Unknown 1 NW_019212893.1 some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; uncharacterized protein 37787 34688497 LALA0_S15e00540g Lachancea lanzarotensis uncharacterized protein XP_022631124.1 36954 R 1245769 CDS LALA0_S15e00562g 34688498 complement(38967..39902) Unknown 1 NW_019212893.1 weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; uncharacterized protein 39902 34688498 LALA0_S15e00562g Lachancea lanzarotensis uncharacterized protein XP_022631125.1 38967 R 1245769 CDS LALA0_S15e00584g 34688499 complement(40572..41669) Unknown 1 NW_019212893.1 weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; uncharacterized protein 41669 34688499 LALA0_S15e00584g Lachancea lanzarotensis uncharacterized protein XP_022631126.1 40572 R 1245769 CDS LALA0_S15e00606g 34688500 43994..46318 Unknown 1 NW_019212893.1 weakly similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Putative protein of unknown function; YLR050W is not an essential gene; uncharacterized protein 46318 34688500 LALA0_S15e00606g Lachancea lanzarotensis uncharacterized protein XP_022631127.1 43994 D 1245769 CDS LALA0_S15e00628g 34688501 complement(46600..48009) Unknown 1 NW_019212893.1 highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; glycine hydroxymethyltransferase SHM2 48009 34688501 LALA0_S15e00628g Lachancea lanzarotensis glycine hydroxymethyltransferase SHM2 XP_022631128.1 46600 R 1245769 CDS LALA0_S15e00650g 34688502 complement(49349..50473) Unknown 1 NW_019212893.1 similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W AGX1 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases; alanine--glyoxylate transaminase 50473 34688502 LALA0_S15e00650g Lachancea lanzarotensis alanine--glyoxylate transaminase XP_022631129.1 49349 R 1245769 CDS LALA0_S15e00672g 34688503 complement(50695..51588) Unknown 1 NW_019212893.1 weakly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family; uncharacterized protein 51588 34688503 LALA0_S15e00672g Lachancea lanzarotensis uncharacterized protein XP_022631130.1 50695 R 1245769 CDS LALA0_S15e00694g 34688504 complement(52065..53039) Unknown 1 NW_019212893.1 weakly similar to uniprot|P03870 Saccharomyces cerevisiae R0010W FLP1 Site-specific recombinase Flp; uncharacterized protein 53039 34688504 LALA0_S15e00694g Lachancea lanzarotensis uncharacterized protein XP_022631131.1 52065 R 1245769 CDS LALA0_S15e00716g 34688505 complement(53979..54809) Unknown 1 NW_019212893.1 weakly similar to uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; transcription factor HAC1 54809 34688505 LALA0_S15e00716g Lachancea lanzarotensis transcription factor HAC1 XP_022631132.1 53979 R 1245769 CDS LALA0_S15e00738g 34688506 complement(55348..56343) Unknown 1 NW_019212893.1 weakly similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; uncharacterized protein 56343 34688506 LALA0_S15e00738g Lachancea lanzarotensis uncharacterized protein XP_022631133.1 55348 R 1245769 CDS LALA0_S15e00760g 34688507 57034..61587 Unknown 1 NW_019212893.1 similar to uniprot|P43565 Saccharomyces cerevisiae YFL033C RIM15 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase; protein kinase RIM15 61587 34688507 LALA0_S15e00760g Lachancea lanzarotensis protein kinase RIM15 XP_022631134.1 57034 D 1245769 CDS LALA0_S15e00782g 34688508 61980..63764 Unknown 1 NW_019212893.1 highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control; phenylalanine--tRNA ligase subunit beta 63764 34688508 LALA0_S15e00782g Lachancea lanzarotensis phenylalanine--tRNA ligase subunit beta XP_022631135.1 61980 D 1245769 CDS LALA0_S15e00804g 34688509 complement(63815..66745) Unknown 1 NW_019212893.1 similar to uniprot|P43564 Saccharomyces cerevisiae YFL034W Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk; uncharacterized protein 66745 34688509 LALA0_S15e00804g Lachancea lanzarotensis uncharacterized protein XP_022631136.1 63815 R 1245769 CDS LALA0_S15e00826g 34688510 join(67859..67870,68192..68539) Unknown 1 NW_019212893.1 highly similar to uniprot|P56628 Saccharomyces cerevisiae YFL034C-A (ohnolog of YLR061W) RPL22B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein; 60S ribosomal protein eL22 68539 34688510 LALA0_S15e00826g Lachancea lanzarotensis 60S ribosomal protein eL22 XP_022631137.1 67859 D 1245769 CDS LALA0_S15e00848g 34688511 68978..69919 Unknown 1 NW_019212893.1 similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene; 25S rRNA (uracil2843-N3)-methyltransferase 69919 34688511 LALA0_S15e00848g Lachancea lanzarotensis 25S rRNA (uracil2843-N3)-methyltransferase XP_022631138.1 68978 D 1245769 CDS LALA0_S15e00870g 34688512 join(70220..70242,70317..71148) Unknown 1 NW_019212893.1 highly similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p; uncharacterized protein 71148 34688512 LALA0_S15e00870g Lachancea lanzarotensis uncharacterized protein XP_022631139.1 70220 D 1245769 CDS LALA0_S15e00892g 34688513 complement(71344..75228) Unknown 1 NW_019212893.1 similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W RPO41 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; DNA-directed RNA polymerase 75228 34688513 LALA0_S15e00892g Lachancea lanzarotensis DNA-directed RNA polymerase XP_022631140.1 71344 R 1245769 CDS LALA0_S15e00914g 34688514 complement(join(76058..77395,77561..77572)) Unknown 1 NW_019212893.1 highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; beta-tubulin 77572 34688514 LALA0_S15e00914g Lachancea lanzarotensis beta-tubulin XP_022631141.1 76058 R 1245769 CDS LALA0_S15e00936g 34688515 81203..81817 Unknown 1 NW_019212893.1 highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); Rab family GTPase YPT1 81817 34688515 LALA0_S15e00936g Lachancea lanzarotensis Rab family GTPase YPT1 XP_022631142.1 81203 D 1245769 CDS LALA0_S15e00958g 34688516 complement(82052..82576) Unknown 1 NW_019212893.1 similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Putative protein of unknown function; YLR065C is not an essential gene; uncharacterized protein 82576 34688516 LALA0_S15e00958g Lachancea lanzarotensis uncharacterized protein XP_022631143.1 82052 R 1245769 CDS LALA0_S15e00980g 34688517 join(83354..83363,84103..85220) Unknown 1 NW_019212893.1 highly similar to uniprot|P02579 Saccharomyces cerevisiae YFL039C ACT1 Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; actin 85220 34688517 LALA0_S15e00980g Lachancea lanzarotensis actin XP_022631144.1 83354 D 1245769 CDS LALA0_S15e01002g 34688518 complement(85514..87034) Unknown 1 NW_019212893.1 similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W Putative transporter, member of the sugar porter family; YFL040W is not an essential gene; uncharacterized protein 87034 34688518 LALA0_S15e01002g Lachancea lanzarotensis uncharacterized protein XP_022631145.1 85514 R 1245769 CDS LALA0_S15e01024g 34688519 join(87439..87590,87667..88114) Unknown 1 NW_019212893.1 similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; signal peptidase complex subunit SPC3 88114 34688519 LALA0_S15e01024g Lachancea lanzarotensis signal peptidase complex subunit SPC3 XP_022631146.1 87439 D 1245769 CDS LALA0_S15e01046g 34688520 complement(88268..91096) Unknown 1 NW_019212893.1 similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); uncharacterized protein 91096 34688520 LALA0_S15e01046g Lachancea lanzarotensis uncharacterized protein XP_022631147.1 88268 R 1245769 CDS LALA0_S15e01068g 34688521 91488..91928 Unknown 1 NW_019212893.1 similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin; uncharacterized protein 91928 34688521 LALA0_S15e01068g Lachancea lanzarotensis uncharacterized protein XP_022631148.1 91488 D 1245769 CDS LALA0_S15e01090g 34688522 complement(92111..94402) Unknown 1 NW_019212893.1 highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 Mitochondrial elongation factor involved in translational elongation; uncharacterized protein 94402 34688522 LALA0_S15e01090g Lachancea lanzarotensis uncharacterized protein XP_022631149.1 92111 R 1245769 CDS LALA0_S15e01112g 34688523 complement(94600..96438) Unknown 1 NW_019212893.1 similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W FET5 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport; ferroxidase FET5 96438 34688523 LALA0_S15e01112g Lachancea lanzarotensis ferroxidase FET5 XP_022631150.1 94600 R 1245769 CDS LALA0_S15e01134g 34688524 complement(97395..98459) Unknown 1 NW_019212893.1 similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; D-xylulose reductase XYL2 98459 34688524 LALA0_S15e01134g Lachancea lanzarotensis D-xylulose reductase XYL2 XP_022631151.1 97395 R 1245769 CDS LALA0_S15e01156g 34688525 complement(98892..101900) Unknown 1 NW_019212893.1 similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation; uncharacterized protein 101900 34688525 LALA0_S15e01156g Lachancea lanzarotensis uncharacterized protein XP_022631152.1 98892 R 1245769 CDS LALA0_S15e01178g 34688526 102613..105390 Unknown 1 NW_019212893.1 some similarities with uniprot|P43560 Saccharomyces cerevisiae YFL042C (ohnolog of YLR072W) Putative protein of unknown function; YFL042C is not an essential gene; uncharacterized protein 105390 34688526 LALA0_S15e01178g Lachancea lanzarotensis uncharacterized protein XP_022631153.1 102613 D 1245769 CDS LALA0_S15e01200g 34688527 complement(105445..106020) Unknown 1 NW_019212893.1 similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C RFU1 Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes; uncharacterized protein 106020 34688527 LALA0_S15e01200g Lachancea lanzarotensis uncharacterized protein XP_022631154.1 105445 R 1245769 CDS LALA0_S15e01222g 34688528 106923..107891 Unknown 1 NW_019212893.1 similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C OTU1 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; ubiquitin-specific protease OTU1 107891 34688528 LALA0_S15e01222g Lachancea lanzarotensis ubiquitin-specific protease OTU1 XP_022631155.1 106923 D 1245769 CDS LALA0_S15e01244g 34688529 complement(108023..108520) Unknown 1 NW_019212893.1 similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 108520 34688529 LALA0_S15e01244g Lachancea lanzarotensis uncharacterized protein XP_022631156.1 108023 R 1245769 CDS LALA0_S15e01266g 34688530 109482..110144 Unknown 1 NW_019212893.1 highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W RPL10 Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family; 60S ribosomal protein uL16 110144 34688530 LALA0_S15e01266g Lachancea lanzarotensis 60S ribosomal protein uL16 XP_022631157.1 109482 D 1245769 CDS LALA0_S15e01288g 34688531 110878..111645 Unknown 1 NW_019212893.1 highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; phosphomannomutase SEC53 111645 34688531 LALA0_S15e01288g Lachancea lanzarotensis phosphomannomutase SEC53 XP_022631158.1 110878 D 1245769 CDS LALA0_S15e01310g 34688532 complement(111742..112413) Unknown 1 NW_019212893.1 similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 112413 34688532 LALA0_S15e01310g Lachancea lanzarotensis uncharacterized protein XP_022631159.1 111742 R 1245769 CDS LALA0_S15e01332g 34688533 112605..114383 Unknown 1 NW_019212893.1 similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria; uncharacterized protein 114383 34688533 LALA0_S15e01332g Lachancea lanzarotensis uncharacterized protein XP_022631160.1 112605 D 1245769 CDS LALA0_S15e01354g 34688534 complement(join(114453..115169,115244..115246)) Unknown 1 NW_019212893.1 similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; uncharacterized protein 115246 34688534 LALA0_S15e01354g Lachancea lanzarotensis uncharacterized protein XP_022631161.1 114453 R 1245769 CDS LALA0_S15e01376g 34688535 116232..117128 Unknown 1 NW_019212893.1 weakly similar to uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1; cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 117128 34688535 LALA0_S15e01376g Lachancea lanzarotensis cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 XP_022631162.1 116232 D 1245769 CDS LALA0_S15e01398g 34688536 complement(117250..119355) Unknown 1 NW_019212893.1 similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; GTPase-activating protein RGD2 119355 34688536 LALA0_S15e01398g Lachancea lanzarotensis GTPase-activating protein RGD2 XP_022631163.1 117250 R 1245769 CDS LALA0_S15e01420g 34688537 119474..119842 Unknown 1 NW_019212893.1 similar to GI|495487560 Rhodanobacter sp. 2,4-dichlorophenol 6-monooxygenase; uncharacterized protein 119842 34688537 LALA0_S15e01420g Lachancea lanzarotensis uncharacterized protein XP_022631164.1 119474 D 1245769 CDS LALA0_S15e01442g 34688538 120502..121797 Unknown 1 NW_019212893.1 similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C (ohnolog of YLR080W) EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; uncharacterized protein 121797 34688538 LALA0_S15e01442g Lachancea lanzarotensis uncharacterized protein XP_022631165.1 120502 D 1245769 CDS LALA0_S15e01464g 34688539 complement(121859..123418) Unknown 1 NW_019212893.1 weakly similar to uniprot|P43554 Saccharomyces cerevisiae YFL049W SWP82 Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; uncharacterized protein 123418 34688539 LALA0_S15e01464g Lachancea lanzarotensis uncharacterized protein XP_022631166.1 121859 R 1245769 CDS LALA0_S15e01486g 34688540 124632..126227 Unknown 1 NW_019212893.1 similar to Lachancea thermotolerans KLTH0F00110g hypothetical protein; uncharacterized protein 126227 34688540 LALA0_S15e01486g Lachancea lanzarotensis uncharacterized protein XP_022631167.1 124632 D 1245769 CDS LALA0_S15e01508g 34688541 complement(126463..127857) Unknown 1 NW_019212893.1 highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; argininosuccinate lyase ARG4 127857 34688541 LALA0_S15e01508g Lachancea lanzarotensis argininosuccinate lyase ARG4 XP_022631168.1 126463 R 1245769 CDS LALA0_S15e01530g 34688542 complement(128158..129063) Unknown 1 NW_019212893.1 similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Putative protein of unknown function; proposed to be a palmitoylated membrane protein; uncharacterized protein 129063 34688542 LALA0_S15e01530g Lachancea lanzarotensis uncharacterized protein XP_022631169.1 128158 R 1245769 CDS LALA0_S15e01552g 34688543 130491..131897 Unknown 1 NW_019212893.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 131897 34688543 LALA0_S15e01552g Lachancea lanzarotensis uncharacterized protein XP_022631170.1 130491 D 1245769 CDS LALA0_S15e01574g 34688544 134600..135496 Unknown 1 NW_019212893.1 similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; uncharacterized protein 135496 34688544 LALA0_S15e01574g Lachancea lanzarotensis uncharacterized protein XP_022631171.1 134600 D 1245769 CDS LALA0_S15e01596g 34688545 complement(135948..136793) Unknown 1 NW_019212893.1 highly similar to uniprot|C5E3F9 Lachancea thermotolerans KLTH0H13090g hypothetical protein; uncharacterized protein 136793 34688545 LALA0_S15e01596g Lachancea lanzarotensis uncharacterized protein XP_022631172.1 135948 R 1245769 CDS LALA0_S15e01618g 34688546 138332..139231 Unknown 1 NW_019212893.1 similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; uncharacterized protein 139231 34688546 LALA0_S15e01618g Lachancea lanzarotensis uncharacterized protein XP_022631173.1 138332 D 1245769 CDS LALA0_S15e01640g 34688547 140285..141181 Unknown 1 NW_019212893.1 similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; uncharacterized protein 141181 34688547 LALA0_S15e01640g Lachancea lanzarotensis uncharacterized protein XP_022631174.1 140285 D 1245769 CDS LALA0_S15e01662g 34688548 143062..143964 Unknown 1 NW_019212893.1 similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; uncharacterized protein 143964 34688548 LALA0_S15e01662g Lachancea lanzarotensis uncharacterized protein XP_022631175.1 143062 D 1245769 CDS LALA0_S15e01684g 34688549 complement(144190..145935) Unknown 1 NW_019212893.1 weakly similar to uniprot|P53745 Saccharomyces cerevisiae YNR059W MNT4 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation; uncharacterized protein 145935 34688549 LALA0_S15e01684g Lachancea lanzarotensis uncharacterized protein XP_022631176.1 144190 R 1245769 CDS LALA0_S15e01750g 34688550 147046..147756 Unknown 1 NW_019212893.1 highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress; ribulose-phosphate 3-epimerase RPE1 147756 34688550 LALA0_S15e01750g Lachancea lanzarotensis ribulose-phosphate 3-epimerase RPE1 XP_022631177.1 147046 D 1245769 CDS LALA0_S15e01772g 34688551 complement(147863..148336) Unknown 1 NW_019212893.1 similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W ALB1 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p; uncharacterized protein 148336 34688551 LALA0_S15e01772g Lachancea lanzarotensis uncharacterized protein XP_022631178.1 147863 R 1245769 CDS LALA0_S15e01794g 34688552 149116..150486 Unknown 1 NW_019212893.1 similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C MTC1 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1; uncharacterized protein 150486 34688552 LALA0_S15e01794g Lachancea lanzarotensis uncharacterized protein XP_022631179.1 149116 D 1245769 CDS LALA0_S15e01816g 34688553 complement(150590..150976) Unknown 1 NW_019212893.1 similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 150976 34688553 LALA0_S15e01816g Lachancea lanzarotensis uncharacterized protein XP_022631180.1 150590 R 1245769 CDS LALA0_S15e01838g 34688554 151485..151979 Unknown 1 NW_019212893.1 similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; uncharacterized protein 151979 34688554 LALA0_S15e01838g Lachancea lanzarotensis uncharacterized protein XP_022631181.1 151485 D 1245769 CDS LALA0_S15e01860g 34688555 152300..153499 Unknown 1 NW_019212893.1 similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; tRNA 1-methyladenosine methyltransferase subunit GCD14 153499 34688555 LALA0_S15e01860g Lachancea lanzarotensis tRNA 1-methyladenosine methyltransferase subunit GCD14 XP_022631182.1 152300 D 1245769 CDS LALA0_S15e01882g 34688556 complement(153552..154460) Unknown 1 NW_019212893.1 similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W NIT2 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; uncharacterized protein 154460 34688556 LALA0_S15e01882g Lachancea lanzarotensis uncharacterized protein XP_022631183.1 153552 R 1245769 CDS LALA0_S16e00100g 34688557 1661..2659 Unknown 1 NW_019212894.1 similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; uncharacterized protein 2659 34688557 LALA0_S16e00100g Lachancea lanzarotensis uncharacterized protein XP_022631184.1 1661 D 1245769 CDS LALA0_S16e00122g 34688558 5435..6562 Unknown 1 NW_019212894.1 highly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; uncharacterized protein 6562 34688558 LALA0_S16e00122g Lachancea lanzarotensis uncharacterized protein XP_022631185.1 5435 D 1245769 CDS LALA0_S16e00144g 34688559 complement(6949..8097) Unknown 1 NW_019212894.1 highly similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W ADH4 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; uncharacterized protein 8097 34688559 LALA0_S16e00144g Lachancea lanzarotensis uncharacterized protein XP_022631186.1 6949 R 1245769 CDS LALA0_S16e00166g 34688560 complement(9899..11680) Unknown 1 NW_019212894.1 similar to uniprot|Q08579 Saccharomyces cerevisiae YOR192C THI72 Transporter of thiamine or related compound; shares sequence similarity with Thi7p; uncharacterized protein 11680 34688560 LALA0_S16e00166g Lachancea lanzarotensis uncharacterized protein XP_022631187.1 9899 R 1245769 CDS LALA0_S16e00188g 34688561 13955..14215 Unknown 1 NW_019212894.1 similar to uniprot|C5DC55 Lachancea thermotolerans KLTH0B00110g putative transmembrane transporter; uncharacterized protein 14215 34688561 LALA0_S16e00188g Lachancea lanzarotensis uncharacterized protein XP_022631188.1 13955 D 1245769 CDS LALA0_S16e00210g 34688562 14942..16225 Unknown 1 NW_019212894.1 similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene; uncharacterized protein 16225 34688562 LALA0_S16e00210g Lachancea lanzarotensis uncharacterized protein XP_022631189.1 14942 D 1245769 CDS LALA0_S16e00232g 34688563 16540..17118 Unknown 1 NW_019212894.1 weakly similar to uniprot|P26188 Saccharomyces cerevisiae YDL200C MGT1 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage; uncharacterized protein 17118 34688563 LALA0_S16e00232g Lachancea lanzarotensis uncharacterized protein XP_022631190.1 16540 D 1245769 CDS LALA0_S16e00254g 34688564 complement(17135..18781) Unknown 1 NW_019212894.1 similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; uncharacterized protein 18781 34688564 LALA0_S16e00254g Lachancea lanzarotensis uncharacterized protein XP_022631191.1 17135 R 1245769 CDS LALA0_S16e00276g 34688565 complement(19238..21682) Unknown 1 NW_019212894.1 similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C YME2 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases; uncharacterized protein 21682 34688565 LALA0_S16e00276g Lachancea lanzarotensis uncharacterized protein XP_022631192.1 19238 R 1245769 CDS LALA0_S16e00298g 34688566 22163..25732 Unknown 1 NW_019212894.1 similar to uniprot|P50101 Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; ubiquitin-specific protease UBP15 25732 34688566 LALA0_S16e00298g Lachancea lanzarotensis ubiquitin-specific protease UBP15 XP_022631193.1 22163 D 1245769 CDS LALA0_S16e00320g 34688567 complement(25779..26657) Unknown 1 NW_019212894.1 similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C CAB4 Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved; uncharacterized protein 26657 34688567 LALA0_S16e00320g Lachancea lanzarotensis uncharacterized protein XP_022631194.1 25779 R 1245769 CDS LALA0_S16e00342g 34688568 26781..28487 Unknown 1 NW_019212894.1 similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein; U2-type spliceosomal complex subunit CWC22 28487 34688568 LALA0_S16e00342g Lachancea lanzarotensis U2-type spliceosomal complex subunit CWC22 XP_022631195.1 26781 D 1245769 CDS LALA0_S16e00364g 34688569 complement(28821..30005) Unknown 1 NW_019212894.1 similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C (ohnolog of YMR305C) SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; uncharacterized protein 30005 34688569 LALA0_S16e00364g Lachancea lanzarotensis uncharacterized protein XP_022631196.1 28821 R 1245769 CDS LALA0_S16e00386g 34688570 31432..36729 Unknown 1 NW_019212894.1 highly similar to uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 36729 34688570 LALA0_S16e00386g Lachancea lanzarotensis uncharacterized protein XP_022631197.1 31432 D 1245769 CDS LALA0_S16e00408g 34688571 37748..39400 Unknown 1 NW_019212894.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery; 1,3-beta-glucanosyltransferase GAS1 39400 34688571 LALA0_S16e00408g Lachancea lanzarotensis 1,3-beta-glucanosyltransferase GAS1 XP_022631198.1 37748 D 1245769 CDS LALA0_S16e00430g 34688572 40205..41851 Unknown 1 NW_019212894.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery; uncharacterized protein 41851 34688572 LALA0_S16e00430g Lachancea lanzarotensis uncharacterized protein XP_022631199.1 40205 D 1245769 CDS LALA0_S16e00452g 34688573 complement(42574..43494) Unknown 1 NW_019212894.1 similar to uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain; telomerase inhibitor 43494 34688573 LALA0_S16e00452g Lachancea lanzarotensis telomerase inhibitor XP_022631200.1 42574 R 1245769 CDS LALA0_S16e00474g 34688574 complement(44123..47401) Unknown 1 NW_019212894.1 highly similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; uncharacterized protein 47401 34688574 LALA0_S16e00474g Lachancea lanzarotensis uncharacterized protein XP_022631201.1 44123 R 1245769 CDS LALA0_S16e00496g 34688575 47837..50050 Unknown 1 NW_019212894.1 weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 50050 34688575 LALA0_S16e00496g Lachancea lanzarotensis uncharacterized protein XP_022631202.1 47837 D 1245769 CDS LALA0_S16e00518g 34688576 55379..59719 Unknown 1 NW_019212894.1 similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR); ATP-binding cassette transporter YOR1 59719 34688576 LALA0_S16e00518g Lachancea lanzarotensis ATP-binding cassette transporter YOR1 XP_022631203.1 55379 D 1245769 CDS LALA0_S16e00540g 34688577 60697..61758 Unknown 1 NW_019212894.1 similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; uncharacterized protein 61758 34688577 LALA0_S16e00540g Lachancea lanzarotensis uncharacterized protein XP_022631204.1 60697 D 1245769 CDS LALA0_S16e00562g 34688578 complement(63865..66114) Unknown 1 NW_019212894.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p; 66114 34688578 LALA0_S16e00562g Lachancea lanzarotensis 63865 R 1245769 CDS LALA0_S17e00100g 34688579 complement(1..2031) Unknown 1 NW_019212895.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p; 2031 34688579 LALA0_S17e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S17e00122g 34688580 3370..3876 Unknown 1 NW_019212895.1 hypothetical protein; uncharacterized protein 3876 34688580 LALA0_S17e00122g Lachancea lanzarotensis uncharacterized protein XP_022631205.1 3370 D 1245769 CDS LALA0_S17e00144g 34688581 complement(4677..5282) Unknown 1 NW_019212895.1 weakly similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 5282 34688581 LALA0_S17e00144g Lachancea lanzarotensis uncharacterized protein XP_022631206.1 4677 R 1245769 CDS LALA0_S17e00166g 34688582 6070..7764 Unknown 1 NW_019212895.1 weakly similar to uniprot|P24813 Saccharomyces cerevisiae YDR423C (ohnolog of YML007W) CAD1 AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; uncharacterized protein 7764 34688582 LALA0_S17e00166g Lachancea lanzarotensis uncharacterized protein XP_022631207.1 6070 D 1245769 CDS LALA0_S17e00188g 34688583 9078..11225 Unknown 1 NW_019212895.1 weakly similar to uniprot|P32578 Saccharomyces cerevisiae YDR422C SIP1 Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions; uncharacterized protein 11225 34688583 LALA0_S17e00188g Lachancea lanzarotensis uncharacterized protein XP_022631208.1 9078 D 1245769 CDS LALA0_S17e00210g 34688584 complement(11293..13275) Unknown 1 NW_019212895.1 weakly similar to uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway; uncharacterized protein 13275 34688584 LALA0_S17e00210g Lachancea lanzarotensis uncharacterized protein XP_022631209.1 11293 R 1245769 CDS LALA0_S17e00232g 34688585 complement(14610..20630) Unknown 1 NW_019212895.1 weakly similar to uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; uncharacterized protein 20630 34688585 LALA0_S17e00232g Lachancea lanzarotensis uncharacterized protein XP_022631210.1 14610 R 1245769 CDS LALA0_S17e00254g 34688586 complement(21513..22928) Unknown 1 NW_019212895.1 similar to uniprot|P32317 Saccharomyces cerevisiae YEL052W AFG1 Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain; uncharacterized protein 22928 34688586 LALA0_S17e00254g Lachancea lanzarotensis uncharacterized protein XP_022631211.1 21513 R 1245769 CDS LALA0_S17e00276g 34688587 23406..25691 Unknown 1 NW_019212895.1 similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible; uncharacterized protein 25691 34688587 LALA0_S17e00276g Lachancea lanzarotensis uncharacterized protein XP_022631212.1 23406 D 1245769 CDS LALA0_S17e00298g 34688588 26654..27151 Unknown 1 NW_019212895.1 highly similar to uniprot|P17079 Saccharomyces cerevisiae YEL054C (ohnolog of YDR418W) RPL12A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins; 60S ribosomal protein uL11 27151 34688588 LALA0_S17e00298g Lachancea lanzarotensis 60S ribosomal protein uL11 XP_022631213.1 26654 D 1245769 CDS LALA0_S17e00320g 34688589 28149..29039 Unknown 1 NW_019212895.1 some similarities with uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; uncharacterized protein 29039 34688589 LALA0_S17e00320g Lachancea lanzarotensis uncharacterized protein XP_022631214.1 28149 D 1245769 CDS LALA0_S17e00342g 34688590 29390..31273 Unknown 1 NW_019212895.1 similar to uniprot|Q04049 Saccharomyces cerevisiae YDR419W RAD30 DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV; DNA-directed DNA polymerase eta 31273 34688590 LALA0_S17e00342g Lachancea lanzarotensis DNA-directed DNA polymerase eta XP_022631215.1 29390 D 1245769 CDS LALA0_S17e00386g 34688592 complement(31767..32141) Unknown 1 NW_019212895.1 similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; uncharacterized protein 32141 34688592 LALA0_S17e00386g Lachancea lanzarotensis uncharacterized protein XP_022631216.1 31767 R 1245769 CDS LALA0_S17e00408g 34688593 complement(32390..35158) Unknown 1 NW_019212895.1 weakly similar to uniprot|P50111 Saccharomyces cerevisiae YMR273C (ohnolog of YML109W) ZDS1 Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation; uncharacterized protein 35158 34688593 LALA0_S17e00408g Lachancea lanzarotensis uncharacterized protein XP_022631217.1 32390 R 1245769 CDS LALA0_S17e00430g 34688594 complement(35512..36465) Unknown 1 NW_019212895.1 similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone; CAAX prenyl protease 36465 34688594 LALA0_S17e00430g Lachancea lanzarotensis CAAX prenyl protease XP_022631218.1 35512 R 1245769 CDS LALA0_S17e00474g 34688596 38226..39146 Unknown 1 NW_019212895.1 highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 39146 34688596 LALA0_S17e00474g Lachancea lanzarotensis 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase XP_022631219.1 38226 D 1245769 CDS LALA0_S17e00496g 34688597 complement(39222..41930) Unknown 1 NW_019212895.1 similar to uniprot|P48524 Saccharomyces cerevisiae YMR275C (ohnolog of YML111W) BUL1 Ubiquitin-bindingcomponent of the Rsp5p E3-ubiquitin ligase complex,functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting ofamino acid permeases; ubiquitin-ubiquitin ligase BUL2 41930 34688597 LALA0_S17e00496g Lachancea lanzarotensis ubiquitin-ubiquitin ligase BUL2 XP_022631220.1 39222 R 1245769 CDS LALA0_S17e00518g 34688598 complement(42461..43351) Unknown 1 NW_019212895.1 similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; uncharacterized protein 43351 34688598 LALA0_S17e00518g Lachancea lanzarotensis uncharacterized protein XP_022631221.1 42461 R 1245769 CDS LALA0_S17e00540g 34688599 complement(43656..44591) Unknown 1 NW_019212895.1 weakly similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability; uncharacterized protein 44591 34688599 LALA0_S17e00540g Lachancea lanzarotensis uncharacterized protein XP_022631222.1 43656 R 1245769 CDS LALA0_S18e00100g 34688600 complement(1..1665) Unknown 1 NW_019212896.1 some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p; 1665 34688600 LALA0_S18e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S18e00122g 34688601 complement(3812..5002) Unknown 1 NW_019212896.1 highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W (ohnolog of YJR148W) BAT1 Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; uncharacterized protein 5002 34688601 LALA0_S18e00122g Lachancea lanzarotensis uncharacterized protein XP_022631223.1 3812 R 1245769 CDS LALA0_S18e00144g 34688602 6900..7559 Unknown 1 NW_019212896.1 similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis; 5-formyltetrahydrofolate cyclo-ligase 7559 34688602 LALA0_S18e00144g Lachancea lanzarotensis 5-formyltetrahydrofolate cyclo-ligase XP_022631224.1 6900 D 1245769 CDS LALA0_S18e00166g 34688603 complement(7633..8343) Unknown 1 NW_019212896.1 similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; uncharacterized protein 8343 34688603 LALA0_S18e00166g Lachancea lanzarotensis uncharacterized protein XP_022631225.1 7633 R 1245769 CDS LALA0_S18e00188g 34688604 8703..10184 Unknown 1 NW_019212896.1 similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5 Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; S-adenosylmethionine-dependent methyltransferase 10184 34688604 LALA0_S18e00188g Lachancea lanzarotensis S-adenosylmethionine-dependent methyltransferase XP_022631226.1 8703 D 1245769 CDS LALA0_S18e00210g 34688605 complement(10323..11726) Unknown 1 NW_019212896.1 similar to uniprot|P38889 Saccharomyces cerevisiae YHR206W (ohnolog of YJR147W) SKN7 Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; uncharacterized protein 11726 34688605 LALA0_S18e00210g Lachancea lanzarotensis uncharacterized protein XP_022631227.1 10323 R 1245769 CDS LALA0_S18e00232g 34688606 complement(12203..14527) Unknown 1 NW_019212896.1 similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB; serine/threonine protein kinase SCH9 14527 34688606 LALA0_S18e00232g Lachancea lanzarotensis serine/threonine protein kinase SCH9 XP_022631228.1 12203 R 1245769 CDS LALA0_S18e00254g 34688607 join(17106..17119,17416..18187) Unknown 1 NW_019212896.1 highly similar to uniprot|P0CX36 Saccharomyces cerevisiae YHR203C (ohnolog of YJR145C) RPS4B Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein; 40S ribosomal protein eS4 18187 34688607 LALA0_S18e00254g Lachancea lanzarotensis 40S ribosomal protein eS4 XP_022631229.1 17106 D 1245769 CDS LALA0_S18e00276g 34688608 complement(18380..20140) Unknown 1 NW_019212896.1 similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization; uncharacterized protein 20140 34688608 LALA0_S18e00276g Lachancea lanzarotensis uncharacterized protein XP_022631230.1 18380 R 1245769 CDS LALA0_S18e00298g 34688609 complement(20515..21303) Unknown 1 NW_019212896.1 similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage; uncharacterized protein 21303 34688609 LALA0_S18e00298g Lachancea lanzarotensis uncharacterized protein XP_022631231.1 20515 R 1245769 CDS LALA0_S18e00320g 34688610 21972..24248 Unknown 1 NW_019212896.1 similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals; dolichyl-phosphate-mannose-protein mannosyltransferase 24248 34688610 LALA0_S18e00320g Lachancea lanzarotensis dolichyl-phosphate-mannose-protein mannosyltransferase XP_022631232.1 21972 D 1245769 CDS LALA0_S18e00342g 34688611 complement(24308..25336) Unknown 1 NW_019212896.1 similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; uncharacterized protein 25336 34688611 LALA0_S18e00342g Lachancea lanzarotensis uncharacterized protein XP_022631233.1 24308 R 1245769 CDS LALA0_S18e00364g 34688612 26249..27403 Unknown 1 NW_019212896.1 similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix; exopolyphosphatase 27403 34688612 LALA0_S18e00364g Lachancea lanzarotensis exopolyphosphatase XP_022631234.1 26249 D 1245769 CDS LALA0_S18e00386g 34688613 complement(27416..28480) Unknown 1 NW_019212896.1 similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Essential protein of unknown function; uncharacterized protein 28480 34688613 LALA0_S18e00386g Lachancea lanzarotensis uncharacterized protein XP_022631235.1 27416 R 1245769 CDS LALA0_S18e00408g 34688614 30110..35050 Unknown 1 NW_019212896.1 similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein; uncharacterized protein 35050 34688614 LALA0_S18e00408g Lachancea lanzarotensis uncharacterized protein XP_022631236.1 30110 D 1245769 CDS LALA0_S18e00430g 34688615 join(35805..35838,36000..37033) Unknown 1 NW_019212896.1 highly similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions; homoserine dehydrogenase 37033 34688615 LALA0_S18e00430g Lachancea lanzarotensis homoserine dehydrogenase XP_022631237.1 35805 D 1245769 CDS LALA0_S18e00452g 34688616 complement(37172..41791) Unknown 1 NW_019212896.1 similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal CDC48-like domain and a C-terminal DEP domain; central region is readily accessible to proteases; GTPase-activating protein IML1 41791 34688616 LALA0_S18e00452g Lachancea lanzarotensis GTPase-activating protein IML1 XP_022631238.1 37172 R 1245769 CDS LALA0_S18e00474g 34688617 complement(42481..43266) Unknown 1 NW_019212896.1 highly similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein; proteasome regulatory particle base subunit RPN10 43266 34688617 LALA0_S18e00474g Lachancea lanzarotensis proteasome regulatory particle base subunit RPN10 XP_022631239.1 42481 R 1245769 CDS LALA0_S19e00100g 34688618 join(3416..3694,3694..4161,4160..4357,4359..4565) Unknown 1 NW_019212897.1 some similarities with uniprot|C5DHK8 Lachancea thermotolerans KLTH0E05148g hypothetical protein; 4565 34688618 LALA0_S19e00100g Lachancea lanzarotensis 3416 D 1245769 CDS LALA0_S19e00122g 34688619 5505..7211 Unknown 1 NW_019212897.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; uncharacterized protein 7211 34688619 LALA0_S19e00122g Lachancea lanzarotensis uncharacterized protein XP_022631240.1 5505 D 1245769 CDS LALA0_S19e00144g 34688620 complement(9619..10620) Unknown 1 NW_019212897.1 similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; uncharacterized protein 10620 34688620 LALA0_S19e00144g Lachancea lanzarotensis uncharacterized protein XP_022631241.1 9619 R 1245769 CDS LALA0_S19e00166g 34688621 complement(11184..12509) Unknown 1 NW_019212897.1 some similarities with uniprot|P40896 Saccharomyces cerevisiae YJL213W Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p; uncharacterized protein 12509 34688621 LALA0_S19e00166g Lachancea lanzarotensis uncharacterized protein XP_022631242.1 11184 R 1245769 CDS LALA0_S19e00188g 34688622 13201..14676 Unknown 1 NW_019212897.1 weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 14676 34688622 LALA0_S19e00188g Lachancea lanzarotensis uncharacterized protein XP_022631243.1 13201 D 1245769 CDS LALA0_S19e00210g 34688623 20468..21595 Unknown 1 NW_019212897.1 highly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; uncharacterized protein 21595 34688623 LALA0_S19e00210g Lachancea lanzarotensis uncharacterized protein XP_022631244.1 20468 D 1245769 CDS LALA0_S19e00232g 34688624 complement(21977..23125) Unknown 1 NW_019212897.1 highly similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W ADH4 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; uncharacterized protein 23125 34688624 LALA0_S19e00232g Lachancea lanzarotensis uncharacterized protein XP_022631245.1 21977 R 1245769 CDS LALA0_S19e00254g 34688625 24522..24782 Unknown 1 NW_019212897.1 similar to uniprot|A8WRF6 Caenorhabditis briggsae CBG01854 hypothetical protein; uncharacterized protein 24782 34688625 LALA0_S19e00254g Lachancea lanzarotensis uncharacterized protein XP_022631246.1 24522 D 1245769 CDS LALA0_S19e00276g 34688626 join(25930..26409,26411..26644,26644..27054) Unknown 1 NW_019212897.1 similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene; 27054 34688626 LALA0_S19e00276g Lachancea lanzarotensis 25930 D 1245769 CDS LALA0_S19e00298g 34688627 27511..28116 Unknown 1 NW_019212897.1 similar to uniprot|P26188 Saccharomyces cerevisiae YDL200C MGT1 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage; uncharacterized protein 28116 34688627 LALA0_S19e00298g Lachancea lanzarotensis uncharacterized protein XP_022631247.1 27511 D 1245769 CDS LALA0_S19e00320g 34688628 complement(28784..31066) Unknown 1 NW_019212897.1 some similarities with uniprot|A8WRF6 Caenorhabditis briggsae CBG01854 hypothetical protein; 31066 34688628 LALA0_S19e00320g Lachancea lanzarotensis 28784 R 1245769 CDS LALA0_S20e00100g 34688629 2..1195 Unknown 1 NW_019212898.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p; 1195 34688629 LALA0_S20e00100g Lachancea lanzarotensis 2 D 1245769 CDS LALA0_S20e00122g 34688630 3869..4990 Unknown 1 NW_019212898.1 similar to uniprot|P41816 Saccharomyces cerevisiae YPL171C OYE3 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death; uncharacterized protein 4990 34688630 LALA0_S20e00122g Lachancea lanzarotensis uncharacterized protein XP_022631248.1 3869 D 1245769 CDS LALA0_S20e00144g 34688631 8176..9297 Unknown 1 NW_019212898.1 highly similar to uniprot|P25087 Saccharomyces cerevisiae YML008C ERG6 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane; sterol 24-C-methyltransferase 9297 34688631 LALA0_S20e00144g Lachancea lanzarotensis sterol 24-C-methyltransferase XP_022631249.1 8176 D 1245769 CDS LALA0_S20e00166g 34688632 10201..11859 Unknown 1 NW_019212898.1 weakly similar to uniprot|P25346 Saccharomyces cerevisiae YCR098C GIT1 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; uncharacterized protein 11859 34688632 LALA0_S20e00166g Lachancea lanzarotensis uncharacterized protein XP_022631250.1 10201 D 1245769 CDS LALA0_S20e00188g 34688633 12216..13664 Unknown 1 NW_019212898.1 some similarities with uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning; uncharacterized protein 13664 34688633 LALA0_S20e00188g Lachancea lanzarotensis uncharacterized protein XP_022631251.1 12216 D 1245769 CDS LALA0_S20e00210g 34688634 complement(join(13758..13988,14063..14085,14175..14187)) Unknown 1 NW_019212898.1 highly similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex; dynein light chain 14187 34688634 LALA0_S20e00210g Lachancea lanzarotensis dynein light chain XP_022631252.1 13758 R 1245769 CDS LALA0_S20e00232g 34688635 14337..16199 Unknown 1 NW_019212898.1 similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p; uncharacterized protein 16199 34688635 LALA0_S20e00232g Lachancea lanzarotensis uncharacterized protein XP_022631253.1 14337 D 1245769 CDS LALA0_S20e00254g 34688636 16897..18081 Unknown 1 NW_019212898.1 highly similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W RPN9 Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; proteasome regulatory particle lid subunit RPN9 18081 34688636 LALA0_S20e00254g Lachancea lanzarotensis proteasome regulatory particle lid subunit RPN9 XP_022631254.1 16897 D 1245769 CDS LALA0_S20e00276g 34688637 complement(18106..18828) Unknown 1 NW_019212898.1 similar to uniprot|Q04066 Saccharomyces cerevisiae YDR428C BNA7 Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine; arylformamidase 18828 34688637 LALA0_S20e00276g Lachancea lanzarotensis arylformamidase XP_022631255.1 18106 R 1245769 CDS LALA0_S20e00298g 34688638 complement(18969..19820) Unknown 1 NW_019212898.1 similar to uniprot|Q04067 Saccharomyces cerevisiae YDR429C TIF35 eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; translation initiation factor eIF3 core subunit g 19820 34688638 LALA0_S20e00298g Lachancea lanzarotensis translation initiation factor eIF3 core subunit g XP_022631256.1 18969 R 1245769 CDS LALA0_S21e00100g 34688639 38..340 Unknown 1 NW_019212899.1 some similarities with uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; uncharacterized protein 340 34688639 LALA0_S21e00100g Lachancea lanzarotensis uncharacterized protein XP_022631257.1 38 D 1245769 CDS LALA0_S21e00122g 34688640 1685..3490 Unknown 1 NW_019212899.1 some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 3490 34688640 LALA0_S21e00122g Lachancea lanzarotensis uncharacterized protein XP_022631258.1 1685 D 1245769 CDS LALA0_S21e00144g 34688641 complement(3643..5682) Unknown 1 NW_019212899.1 weakly similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W FET5 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport; uncharacterized protein 5682 34688641 LALA0_S21e00144g Lachancea lanzarotensis uncharacterized protein XP_022631259.1 3643 R 1245769 CDS LALA0_S21e00166g 34688642 6654..8078 Unknown 1 NW_019212899.1 similar to Lachancea thermotolerans KLTH0B10318g hypothetical protein; uncharacterized protein 8078 34688642 LALA0_S21e00166g Lachancea lanzarotensis uncharacterized protein XP_022631260.1 6654 D 1245769 CDS LALA0_S21e00188g 34688643 9047..10780 Unknown 1 NW_019212899.1 similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W EFM1 Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein-lysine N-methyltransferase 10780 34688643 LALA0_S21e00188g Lachancea lanzarotensis protein-lysine N-methyltransferase XP_022631261.1 9047 D 1245769 CDS LALA0_S21e00210g 34688644 complement(join(10914..11331,11682..11695)) Unknown 1 NW_019212899.1 highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; cofilin 11695 34688644 LALA0_S21e00210g Lachancea lanzarotensis cofilin XP_022631262.1 10914 R 1245769 CDS LALA0_S21e00232g 34688645 11929..12477 Unknown 1 NW_019212899.1 weakly similar to uniprot|Q07887 Saccharomyces cerevisiae YLL049W LDB18 Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24; uncharacterized protein 12477 34688645 LALA0_S21e00232g Lachancea lanzarotensis uncharacterized protein XP_022631263.1 11929 D 1245769 CDS LALA0_S21e00254g 34688646 complement(12718..14460) Unknown 1 NW_019212899.1 weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene; uncharacterized protein 14460 34688646 LALA0_S21e00254g Lachancea lanzarotensis uncharacterized protein XP_022631264.1 12718 R 1245769 CDS LALA0_S21e00276g 34688647 15476..17122 Unknown 1 NW_019212899.1 similar to uniprot|P38734 Saccharomyces cerevisiae YHL036W MUP3 Low affinity methionine permease, similar to Mup1p; uncharacterized protein 17122 34688647 LALA0_S21e00276g Lachancea lanzarotensis uncharacterized protein XP_022631265.1 15476 D 1245769 CDS LALA0_S21e00298g 34688648 complement(join(17201..17380,17384..17572)) Unknown 1 NW_019212899.1 some similarities with uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; 17572 34688648 LALA0_S21e00298g Lachancea lanzarotensis 17201 R 1245769 CDS LALA0_S22e00100g 34688649 complement(join(1..276,279..443,446..1726)) Unknown 1 NW_019212900.1 putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate; 1726 34688649 LALA0_S22e00100g Lachancea lanzarotensis 1 R 1245769 CDS LALA0_S22e00122g 34688650 2705..4219 Unknown 1 NW_019212900.1 weakly similar to uniprot|P40475 Saccharomyces cerevisiae YIL120W (ohnolog of YNL065W) QDR1 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban; uncharacterized protein 4219 34688650 LALA0_S22e00122g Lachancea lanzarotensis uncharacterized protein XP_022631269.1 2705 D 1245769 CDS LALA0_S22e00144g 34688651 4690..5247 Unknown 1 NW_019212900.1 similar to uniprot|P0CH64 Saccharomyces cerevisiae YNL335W DDI3 Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants; uncharacterized protein 5247 34688651 LALA0_S22e00144g Lachancea lanzarotensis uncharacterized protein XP_022631270.1 4690 D 1245769 CDS LALA0_S22e00166g 34688652 6613..8271 Unknown 1 NW_019212900.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations; uncharacterized protein 8271 34688652 LALA0_S22e00166g Lachancea lanzarotensis uncharacterized protein XP_022631271.1 6613 D 1245769 CDS LALA0_S22e00188g 34688653 complement(8693..10381) Unknown 1 NW_019212900.1 weakly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C ARB1 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; uncharacterized protein 10381 34688653 LALA0_S22e00188g Lachancea lanzarotensis uncharacterized protein XP_022631272.1 8693 R 1245769 CDS LALA0_S22e00210g 34688654 complement(11397..13076) Unknown 1 NW_019212900.1 similar to uniprot|Q12198 Saccharomyces cerevisiae YLL058W Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene; cystathionine gamma-synthase 13076 34688654 LALA0_S22e00210g Lachancea lanzarotensis cystathionine gamma-synthase XP_022631273.1 11397 R 1245769 CDS LALA0_S22e00232g 34688655 complement(14788..>15765) Unknown 1 NW_019212900.1 some similarities with uniprot|C5DG35 Lachancea thermotolerans KLTH0D02090g hypothetical protein; uncharacterized protein 15765 34688655 LALA0_S22e00232g Lachancea lanzarotensis uncharacterized protein XP_022631274.1 14788 R 1245769 CDS LALA0_S23e00100g 34688656 complement(446..1594) Unknown 1 NW_019212901.1 similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; uncharacterized protein 1594 34688656 LALA0_S23e00100g Lachancea lanzarotensis uncharacterized protein XP_022631266.1 446 R 1245769 CDS LALA0_S23e00122g 34688657 complement(3514..5211) Unknown 1 NW_019212901.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; uncharacterized protein 5211 34688657 LALA0_S23e00122g Lachancea lanzarotensis uncharacterized protein XP_022631267.1 3514 R 1245769 CDS LALA0_S23e00144g 34688658 9874..14103 Unknown 1 NW_019212901.1 similar to uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; 14103 34688658 LALA0_S23e00144g Lachancea lanzarotensis 9874 D 1245769 CDS LALA0_S24e00100g 34688659 1796..2707 Unknown 1 NW_019212902.1 similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein,putative inner membrane transporter with a role in oleatemetabolism and glutamate biosynthesis; member of themitochondrial carrier (MCF) family; has similarity withYmc1p; uncharacterized protein 2707 34688659 LALA0_S24e00100g Lachancea lanzarotensis uncharacterized protein XP_022631268.1 1796 D 1245769 CDS