-- dump date 20250517_145709 -- class Genbank::CDS -- table cds_note -- id note CAALFM_C100020CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C100030CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C100040WA Putative transcription factor; Med2 mediator domain; activates transcription in 1-hybrid assay in S. cerevisiae; repressed by Efg1; member of a family of telomere-proximal genes; Tbf1-induced CAALFM_C100060WA Transcriptional corepressor; represses filamentous growth; regulates switching; role in germ tube induction, farnesol response; in repression pathways with Nrg1, Rfg1; farnesol upregulated in biofilm; rat catheter, Spider biofilm repressed CAALFM_C100070WA Mevalonate diphosphate decarboxylase; functional homolog of S. cerevisiae Erg19; possible drug target; regulated by carbon source, yeast-hypha switch, growth phase, antifungals; gene has intron; rat catheter, Spider biofilm repressed CAALFM_C100080CA Protein involved in regulation of carbonic anhydrases; controls CO2 sensing; bZIP domain-containing transcription factor of the ATF/CREB family; null mutant displays slow growth, abnormal colony morphology and invasive growth CAALFM_C100090WA Ortholog(s) have role in ascospore wall assembly, ascospore-type prospore membrane assembly and cytosol, prospore membrane localization CAALFM_C100100CA Cardiolipin synthase; ortholog of S. cerevisiae Crd1; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; mutants are viable; Spider biofilm repressed CAALFM_C100110WA Chaperonin-containing T-complex subunit; role in hyphal morphogenesis, particularly starvation-induced; essential; expression in S. cerevisiae inhibits Ras2-mediated pathways; CCT8 and TRP1 overlap; Spider biofilm repressed CAALFM_C100120CA Phosphoribosylanthranilate isomerase; tryptophan biosynthesis; expected unifunctional, unlike trifunctional enzyme of some other fungi; complements E. coli trpC, S. cerevisiae trp1 mutant; CCT1 and TRP1 overlap; Spider biofilm repressed CAALFM_C100130CA Ortholog(s) have role in Golgi to vacuole transport, cellular sphingolipid homeostasis, retrograde transport, endosome to Golgi and GARP complex localization CAALFM_C100140WA Kelch repeat domain-containing protein; localizes to sites of polarized growth; mutant colonies exhibit slightly decreased filamentation ratio; not required for buccal epithelial cell adherence or virulence in mice CAALFM_C100150CA Beta-arrestin-like protein; involved in pH response; required for pathogenesis, activation of Rim101 and alkaline pH-induced hyphal growth; colony morphology-related gene regulation by Ssn6p negative feedback regulation target CAALFM_C100160CA Putative nucleolar protein with a predicted role in pre-rRNA processing and ribosome biogenesis; repressed by nitric oxide; required for flow model biofilm formation; Spider biofilm repressed CAALFM_C100170WA Putative 2-isopropylmalate synthase; regulated by Nrg1, Mig1, Tup1, Gcn4; induced by human whole blood or PMNs; macrophage/pseudohyphal-repressed after 16h; Spider biofilm repressed CAALFM_C100180WA Ribosomal protein; transposon mutation affects filamentous growth; repressed upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed CAALFM_C100190CA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C100200CA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_C100210CA Ortholog(s) have unfolded protein binding activity, role in protein folding, protein localization to cell surface and integral component of endoplasmic reticulum membrane, mitochondrial outer membrane localization CAALFM_C100220WA Glycosidase; role in vaginal not systemic infection (low pH not neutral); low pH, high iron, fluconazole, Hap43-induced; Rim101-repressed at pH8; rat catheter biofilm induced; Bcr1-repressed in RPMI a/a biofilms CAALFM_C100230CA Ortholog(s) have GDP-dissociation inhibitor activity, GTPase activator activity, role in mitotic spindle orientation checkpoint and Bfa1-Bub2 complex localization CAALFM_C100270WA Predicted ORF in retrotransposon Tca8 with similarity to the Gag region encoding nucleocapsid-like protein; repressed by ciclopirox olamine; filament induced; regulated by Rfg1, Tup1; overlaps orf19.6078.1 CAALFM_C100280CA Putative replication factor C complex protein; periodic mRNA expression, peak at cell-cycle G1/S phase; overlaps orf19.6079 CAALFM_C100290WA Predicted ORF in retrotransposon Tca8 with similarity to the Pol region of retrotransposons encoding reverse transcriptase, protease and integrase; downregulated in response to ciclopirox olamine; F-12/CO2 early biofilm induced CAALFM_C100310WA Putative protein of unknown function; shows colony morphology-related gene regulation by Ssn6p CAALFM_C100320WA Ortholog(s) have protein transporter activity, role in intracellular protein transport, retrograde transport, endosome to Golgi and cytosol, endosome, nucleus, retromer, cargo-selective complex localization CAALFM_C100330CA Putative CCR4-Not complex transcription factor; ortholog of S. cerevisiae Cdc36; Hap43-repressed gene CAALFM_C100340WA Essential protein involved in regulation of MTL gene expression; hemoglobin-regulated inhibitor of white-opaque switching, may affect survival in host; activator of MTLalpha1 and MTLalpha2; transcript activated by hemoglobin CAALFM_C100350CA Heme oxygenase; utilization of hemin iron; transcript induced by heat, low iron, or hemin; repressed by Efg1; induced by low iron; upregulated by Rim101 at pH 8; Hap43-induced; Spider and flow model biofilm induced CAALFM_C100360WA Essential protein with similarity to S. cerevisiae Cdc13p, involved in telomere maintenance CAALFM_C100370WA Protein of unknown function CAALFM_C100380CA Ortholog(s) have peptide alpha-N-acetyltransferase activity and role in N-terminal peptidyl-methionine acetylation, cytoskeleton organization, mitochondrion inheritance, regulation of actin cytoskeleton organization CAALFM_C100390WA Putative sodium transporter; induced by ciclopirox olamine; alkaline induced by Rim101; repressed by high-level peroxide stress; induced in oral candidiasis clinical isolates; possibly essential gene; rat catheter and Spider biofilm induced CAALFM_C100400WA Putative survival factor; stationary phase enriched protein; fluconazole-induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-AT treatment); fungal-specific (no human or murine homolog) CAALFM_C100410CA Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; Spider biofilm induced CAALFM_C100420WA RNA polymerase II holoenzyme/mediator subunit; regulated by Mig1, Tup1; amphotericin B, caspofungin repressed; protein present in exponential and stationary growth phase yeast; Hap43-repressed; Spider biofilm repressed CAALFM_C100430WA Ortholog(s) have phosphatidylinositol-3,5-bisphosphate binding, ubiquitin binding activity CAALFM_C100440WA Putative ubiquitin-specific protease of the 26S proteasome; oxidative stress-induced via Cap1p CAALFM_C100450CA Mitochondrial protein; component of the mitochondrial inner membrane organizing system; role in maintenance of crista junctions and inner membrane architecture; Spider biofilm repressed CAALFM_C100460WA Putative TIM23 translocase complex subunit; membrane-localized; Hap43-repressed CAALFM_C100470CA Ortholog(s) have role in N-acylethanolamine metabolic process, N-acylphosphatidylethanolamine metabolic process and integral component of mitochondrial inner membrane localization CAALFM_C100480CA YEF3-subfamily ABC family protein, predicted not to be a transporter CAALFM_C100490CA Putative glutaredoxin; described as a glutathione reductase; induced by human neutrophils and benomyl treatment; alkaline repressed; regulated by Gcn2 and Gcn4; required for virulence in mouse model; Spider biofilm induced CAALFM_C100500CA Putative monomeric glyoxalase I; oxidative stress-induced via Cap1; flow model and rat catheter biofilm repressed CAALFM_C100510WA Ortholog(s) have 3-methyl-2-oxobutanoate hydroxymethyltransferase activity, role in pantothenate biosynthetic process, respiratory chain complex IV assembly and mitochondrion localization CAALFM_C100520WA Ortholog(s) have phosphatase activity, role in dephosphorylation and cytosol, nucleus localization CAALFM_C100530CA Ortholog of C. dubliniensis CD36 : Cd36_00460, C. parapsilosis CDC317 : CPAR2_800010, Candida tenuis NRRL Y-1498 : CANTEDRAFT_125085 and Debaryomyces hansenii CBS767 : DEHA2D09086g CAALFM_C100540CA Protein with a Bul1 domain; binds the ubiquitin ligase Rsp5 and is involved in intracellular trafficking of a general amino acid permease Gap1; repressed in an azole-resistant strain overexpressing MDR1; Spider biofilm induced CAALFM_C100550WA Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm; Gcn4p-regulated CAALFM_C100560WA Putative co-chaperone; Hap43p-induced gene; mutation confers hypersensitivity to radicicol CAALFM_C100570CA Ortholog(s) have protein kinase activator activity, role in protein phosphorylation, regulation of cytokinesis and chromosome passenger complex, kinetochore microtubule, spindle midzone localization CAALFM_C100580WA Protein of unknown function; Spider biofilm induced CAALFM_C100590WA Translation elongation factor TU; macrophage/pseudohyphal-induced; repressed upon phagocytosis by murine macrophage; levels decrease in stationary phase cells; Spider biofilm repressed CAALFM_C100600WA Putative Anaphase-Promoting Complex/Cyclosome subunit; essential for growth; periodic mRNA expression, peak at cell-cycle S/G2 phase CAALFM_C100610WA Phosphatidylserine decarboxylase; involved in phosphatidylethanolamine synthesis; Spider biofilm repressed CAALFM_C100620WA Mob1/phocein domain protein of RAM signaling network; cell wall integrity; role in cell separation, cortical actin polarization; required for hyphal growth; phosphorylated by Cdc28 on hyphal induction; activates Cbk1; mRNA binds She3 CAALFM_C100630WA Ortholog(s) have mitochondrial membrane localization CAALFM_C100640CA Putative mitochondrial RNA polymerase; repressed in core stress response; Spider biofilm induced CAALFM_C100650CA ESCRT III complex protein; role in proteolytic activation of Rim101 and Rim8 processing/activation; separable roles in RIM101 pathway and in transport from MVB to vacuole; involved in echinocandin and azole sensitivity CAALFM_C100660CA Ortholog(s) have SNAP receptor activity and role in ER to Golgi vesicle-mediated transport, Golgi organization, intra-Golgi vesicle-mediated transport, vesicle fusion with Golgi apparatus CAALFM_C100670CA Predicted Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Uga3, a transcription factor involved in the regulation of gamma-aminobutyrate metabolism genes; rat catheter biofilm induced CAALFM_C100680WA Putative secreted acid sphingomyelin phosphodiesterase; possible Kex2 substrate; transcript increased in an azole-resistant strain that overexpresses MDR1; flow model biofilm induced; F-12/CO2 early biofilm induced CAALFM_C100690WA Ortholog of S. cerevisiae Ric1 guanyl-nucleotide exchange factor; mutant is viable; rat catheter biofilm repressed CAALFM_C100700WA Protein of unknown function; repressed by nitric oxide CAALFM_C100710CA Beta-tubulin; functional homolog of ScTub2; overproduction makes S. cerevisiae inviable; has two introns; GlcNAc, hypha fluconazole-induced; slow growth, ectopic expression increases white-to opaque switch; rat catheter biofilm repressed CAALFM_C100730CA Catalytic subunit of calcineurin (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type virulence, resistance to high pH, Na(+), Li(+), Mn(2+), and fluconazole tolerance; micafungin is fungicidal to null mutant CAALFM_C100740CA Ornithine decarboxylase; enzyme of polyamine biosynthesis; mutant is viable; functionally complements polyamine auxotrophy of S. cerevisiae spe1 mutant; downregulated upon adherence to polystyrene CAALFM_C100750CA Putative ESCRT-0 complex protein with a role in multivesicular body (MVB) trafficking CAALFM_C100760WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C100770CA Similar to S. cerevisiae Rot1p, which is involved in cell wall 1,6-beta-glucan biosynthesis; has predicted transmembrane region; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C100780CA Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis, biofilm formation; Cdc28-Hgc1 maintains Cdc11 S394 phosphorylation during hyphal growth; required for virulence in mice; regulated by Nrg1, Tup1, farnesol CAALFM_C100790WA Ortholog of C. dubliniensis CD36 : Cd36_00740, C. parapsilosis CDC317 : CPAR2_110170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133175 and Debaryomyces hansenii CBS767 : DEHA2D09724g CAALFM_C100800CA C-8 sterol isomerase; enzyme of ergosterol biosynthesis; converts fecosterol to episterol; mutant is hypersensitive to multiple drugs; ketoconazole-induced; flow model and Spider biofilm repressed CAALFM_C100810WA Ortholog(s) have N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity and role in dolichol-linked oligosaccharide biosynthetic process CAALFM_C100820WA Ortholog of C. dubliniensis CD36 : Cd36_00770, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112621, Debaryomyces hansenii CBS767 : DEHA2D09812g and Pichia stipitis Pignal : PICST_61958 CAALFM_C100830WA Protein with a predicted multidrug transporter domain; Hap43-repressed gene CAALFM_C100840CA Transcriptional regulator of cell cycle gene expression; regulates expression of genes involved in DNA replication stress; interacts with Swi4 and Swi6; repressed during core stress response; Spider biofilm repressed CAALFM_C100850WA Protein of unknown function; induced during hyphae development; induced in low iron; Spider biofilm induced CAALFM_C100860WA Ortholog(s) have Atg8 ligase activity, role in C-terminal protein lipidation, CVT pathway, autophagosome assembly, late nucleophagy, mitophagy, piecemeal microautophagy of nucleus and cytosol, nucleus localization CAALFM_C100870WA Acyltransferase that catalyzes diacylglycerol esterification of phospholipids; role in lipid storage, triglyceride biosynthesis; flow model biofilm repressed CAALFM_C100880WA Protein of unknown function; Spider biofilm induced CAALFM_C100890WA Ortholog(s) have GTPase activity, calcium ion binding activity and role in mitochondrion inheritance, mitochondrion-ER tethering, phospholipid homeostasis, regulation of mitochondrion organization CAALFM_C100900WA Putative ribosome biogenesis and nuclear export protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C100910WA Ortholog(s) have cytosol, nucleolus localization CAALFM_C100920WA Ortholog(s) have cell division site, cell tip, cytosol localization CAALFM_C100930CA Protein similar to S. cerevisiae Sin3p (transcriptional corepressor involved in histone deacetylase recruitment); has paired amphipathic helix PAH1 domain; interacts with ScOpi1p, not CaOpi1p; transposon mutation affects filamentous growth CAALFM_C100940WA Putative RNA polymerase II subunit; flucytosine induced CAALFM_C100950CA Polo-like kinase; member of conserved Mcm1 regulon; depletion causes defects in spindle elongation and Cdc35-dependent filamentation; virulence-group-correlated expression; likely essential (UAU1 method); Spider biofilm repressed CAALFM_C100960CA Lysine histone methyltransferase; methylates histone H3 K4; regulates of white-opaque switch, epithelial cell adhesion, agar-embedded filamentation, virulence in mice; unique N-terminus immunogenic in human; rat catheter biofilm repressed CAALFM_C100970WA Ortholog of C. dubliniensis CD36 : Cd36_00920, Debaryomyces hansenii CBS767 : DEHA2F20724g, Pichia stipitis Pignal : PICST_32745 and Candida albicans WO-1 : CAWG_01277 CAALFM_C100980WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C100990CA Putative serine protease and general molecular chaperone; macrophage-induced gene; repressed in core stress response; merged with orf19.3288.1 in Assembly 21 CAALFM_C101000CA Phosphorylated protein of unknown function CAALFM_C101010WA Plasma membrane-localized protein; repressed by nitric oxide; Hap43p-repressed gene CAALFM_C101030WA Major type I protein arginine methyltransferase (PRMT); involved in asymmetric dimethylation of arginine residues; involved in nuclear export of Npl3p; Spider biofilm repressed CAALFM_C101040WA Ortholog(s) have peptide-methionine (R)-S-oxide reductase activity, role in cellular response to oxidative stress and cytosol, mitochondrion, nucleus localization CAALFM_C101050CA Putative enoyl reductase involved in very long chain fatty acid elongation; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C101060WA Putative transcriptional coactivator; caspofungin repressed; involved in virulence CAALFM_C101070CA Has domain(s) with predicted role in cell division, chromosome segregation and MIS12/MIND type complex localization CAALFM_C101080WA Ortholog of C. dubliniensis CD36 : Cd36_01020, C. parapsilosis CDC317 : CPAR2_110130, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93515 and Debaryomyces hansenii CBS767 : DEHA2D14542g CAALFM_C101090CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C101100WA Voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcript regulated by Nrg1 and Mig1; flow model biofilm repressed CAALFM_C101110CA Protein with putative zinc finger; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); upregulation correlates with clinical development of fluconazole resistance CAALFM_C101130WA Putative ubiquitin ligase complex component; induced by heavy metal (cadmium) stress; Hog1-induced; transcript induced by Mnl1p under weak acid stress; flow model biofilm induced; Spider biofilm induced CAALFM_C101140CA Putative type-1 protein phosphatase targeting subunit; transcript repressed by yeast-hyphal switch; transcript induced by Mnl1p under weak acid stress; flow model biofilm induced CAALFM_C101150CA Ortholog(s) have tRNA methyltransferase activity, role in tRNA methylation, wybutosine biosynthetic process and cytosol, mitochondrion, nucleus localization CAALFM_C101160CA Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in the nucleus and cytoplasm; Spider biofilm induced CAALFM_C101170CA Putative Zn(II)2Cys6 transcription factor CAALFM_C101180CA Ortholog(s) have four-way junction DNA binding activity, role in meiotic recombination checkpoint, synaptonemal complex assembly and lateral element localization CAALFM_C101190CA Flavin-containing monooxygenase; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; Spider biofilm repressed CAALFM_C101200WA Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Stb5p; Hap43p-repressed gene CAALFM_C101210WA Ortholog of Candida tropicalis MYA-3404 : CTRG_04422 and Candida albicans WO-1 : CAWG_01254 CAALFM_C101220CA Protein of unknown function; Hap43-repressed; rat catheter and Spider biofilm induced CAALFM_C101240WA Putative aldo/keto reductase; Mig1-regulated CAALFM_C101250WA Protein of unknown function; flow model and Spider biofilm repressed CAALFM_C101260CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, protein complex assembly and TRAPPI protein complex, TRAPPII protein complex, TRAPPIII protein complex, cytosol, nucleus localization CAALFM_C101270WA Protein required for normal filamentous growth; induced during the mating process; mRNA binds She3; activates transcription in 1-hybrid assay in S. cerevisiae CAALFM_C101280CA RNA polymerase II mediator complex subunit CAALFM_C101290CA Ortholog(s) have cytoplasm localization CAALFM_C101300WA Putative thioredoxin; Spider biofilm repressed CAALFM_C101320WA Member of the LETM1-like protein family, mitochondrial membrane protein CAALFM_C101330CA dUTP pyrophosphatase; cell-cycle regulated if expressed in S. cerevisiae; upstream MluI and SCB elements; 17-beta-estradiol, ethynyl estradiol, macrophage induced; decreased in stationary phase yeast; rat catheter, Spider biofilm repressed CAALFM_C101340CA Ortholog of C. dubliniensis CD36 : Cd36_01240, C. parapsilosis CDC317 : CPAR2_109140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114227 and Debaryomyces hansenii CBS767 : DEHA2D15026g CAALFM_C101350CA Translation initiation factor; upregulated in highly virulent strain compared to less virulent strain; antigenic in human; flucytosine induced; downregulated upon phagocytosis by macrophages; Spider biofilm repressed CAALFM_C101360CA Putative glycogen synthesis initiator; regulated by Efg1 and Efh1; Hog1-repressed; colony morphology-related gene regulation by Ssn6; induced by prostaglandins; flow model biofilm induced CAALFM_C101370CA Ribosomal protein S21; regulated by Nrg1, Tup1; colony morphology-related gene regulation by Ssn6; positively regulated by Tbf1, Hap43; Spider biofilm repressed CAALFM_C101380CA Putative tRNA methyltransferase; repressed by prostaglandins; Spider biofilm induced CAALFM_C101390CA Putative transcription factor; S. cerevisiae ortholog Hot1 is required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; filament induced CAALFM_C101400CA Ortholog(s) have sphingosine-1-phosphate phosphatase activity, role in calcium-mediated signaling and endoplasmic reticulum localization CAALFM_C101420CA Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response CAALFM_C101440CA Similar to Pox18, a peroxisomal protein; induced during chlamydospore formation in C. albicans and C. dubliniensis; A21 sequence updated based on new sequence and analysis, the allelic orf19.10841 was reinstated; Spider biofilm induced CAALFM_C101450WA Putative ubiquinol-cytochrome-c reductase; induced upon adherence to polystyrene; flow model biofilm induced; Spider biofilm induced CAALFM_C101460WA Ortholog of Bre4 in S. cerevisiae has a role in brefeldin A resistence; a drug that affect intracellular transport; Spider biofilm induced CAALFM_C101470WA Ortholog(s) have 5S rRNA binding, 7S RNA binding, mRNA binding, poly(A) binding, ribonuclease P RNA binding, tRNA binding activity CAALFM_C101480CA Protein component of the small (40S) subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed CAALFM_C101490WA Plasma membrane protein of unknown function; colony morphology-related gene regulation by Ssn6; repressed by nitric oxide CAALFM_C101510WA Protein of unknown function; merged with orf19.3338; rat catheter, flow and Spider model biofilm induced; promoter bound by Bcr1, Efg1, Ndt80, and Rob1; orf19.3338 Bcr1-repressed in RPMI a/a biofilms CAALFM_C101520CA Mitochondrial Mn-containing superoxide dismutase; protection against oxidative stress; homotetramer active; N-terminal 34 amino acids removed on mitochondrial import; H2O2-induced via Cap1p; Hap43p-, alkaline-downregulated, farnesol-induced CAALFM_C101530CA Putative tRNA-Arg synthetase; essential; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; downregulated by growth in the mouse cecum CAALFM_C101540WA Ortholog(s) have role in positive regulation of protein autoubiquitination, protein deubiquitination and cytoplasm, nucleus localization CAALFM_C101550WA Ortholog(s) have phosphatidylinositol-3-phosphate binding, protein transporter activity and role in ascospore-type prospore membrane assembly, intracellular protein transport, retrograde transport, endosome to Golgi CAALFM_C101560WA Possible SUMO/Smt3 ligase; Rim101-repressed CAALFM_C101570CA Functional homolog of S. cerevisiae Rpb7; essential subunit of RNA Polymerase II; enhances hyperfilamentation of an S. cerevisiae rpb4 mutant; suppresses defects of S. cerevisiae rpb4 and ess1 mutants; Spider biofilm repressed CAALFM_C101580WA Ortholog(s) have structural constituent of ribosome activity and fungal-type vacuole, mitochondrial large ribosomal subunit localization CAALFM_C101590CA Putative RNA polymerase II subunit B150; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test CAALFM_C101600WA Component of mitochondrial ribosome; decreased expression in hyphae compared to yeast-form cells CAALFM_C101610CA Protein of unknown function; Hap43-induced; Spider biofilm induced CAALFM_C101620CA Has domain(s) with predicted oxidoreductase activity and role in metabolic process CAALFM_C101630WA Protein similar to a mitochondrial complex I intermediate-associated protein; fluconazole-repressed; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C101640WA Predicted ribosomal protein S4, component of the small ribosomal subunit; has paralog RPS41 CAALFM_C101650WA Putative inosine 5'-monophosphate 5'-nucleotidase; fungal-specific (no human or murine homolog) CAALFM_C101670CA Putative caspase-like cysteine protease; mutation confers increased sensitivity to nocodazole; periodic mRNA expression, peak at cell-cycle S/G2 phase; mRNA binds She3 CAALFM_C101680CA Ortholog(s) have mitochondrion localization CAALFM_C101690CA Putative succinate-CoA ligase subunit; induced by high iron; fluconazole-induced; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C101700WA Putative chromatin-remodeling enzyme complex protein; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B; rat catheter biofilm induced; sequence variation between haplotype A and haplotype B alleles within strain SC5314 CAALFM_C101710WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C101740WA Carnitine acetyl transferase; required for growth on nonfermentable carbon sources, not for hyphal growth or virulence in mice; induced in macrophage; macrophage/pseudohyphal-repressed after 16 hr; rat catheter, Spider biofilm induced CAALFM_C101750WA Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; flow model biofilm induced CAALFM_C101760WA Protein lacking an ortholog in S. cerevisiae; member of a family of related proteins; transposon mutation affects filamentous growth; macrophage-induced gene; Hap43p-repressed gene CAALFM_C101770WA Putative protein involved in the structural stability of L-A double-stranded RNA-containing particles; downregulated upon adherence to polystyrene CAALFM_C101780CA Putative ion transporter; alkaline induced by Rim101; Plc1-regulated; caspofungin repressed; rat catheter and Spider biofilm induced CAALFM_C101790WA Putative component of the SBF transcription complex involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase; predicted, conserved MBF binding sites upstream of G1/S-regulated genes CAALFM_C101800WA Ortholog of C. dubliniensis CD36 : Cd36_01640, C. parapsilosis CDC317 : CPAR2_106830, Candida tenuis NRRL Y-1498 : cten_CGOB_00039 and Debaryomyces hansenii CBS767 : DEHA2B06578g CAALFM_C101810CA Predicted succinate semialdehyde dehydrogenase; predicted role in glutamate catabolism; transcription regulated by Mig1, Tup1, Gcn4; mutants are viable CAALFM_C101820CA Ortholog(s) have cyclin-dependent protein serine/threonine kinase regulator activity CAALFM_C101830CA Predicted ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase; induced by alpha pheromone in SpiderM medium CAALFM_C101840CA Protein with a Rho GDP-dissociation inhibitor domain; Hap43-repressed gene; Spider biofilm induced CAALFM_C101850CA Ortholog(s) have mRNA binding, protein heterodimerization activity and role in mRNA polyadenylation, pre-mRNA cleavage required for polyadenylation, response to DNA damage checkpoint signaling CAALFM_C101860WA Ortholog(s) have RNA polymerase II core binding, RNA polymerase II regulatory region DNA binding, transcription factor activity, core RNA polymerase II recruiting activity CAALFM_C101870CA Cystathionine beta-synthase; sulfur amino acid biosynthesis; antigenic in mouse; flow model biofilm induced; alkaline induced; macrophage/pseudohyphal-induced; present in exponential and stationary growth phase yeast cultures CAALFM_C101880CA Protein similar to S. cerevisiae Ptr3p, which is a sensor of external amino acids; expression upregulated in an ssr1 null mutant CAALFM_C101890CA Putative UBX-domain (ubiquitin-regulatory domain) protein; macrophage-downregulated gene CAALFM_C101900CA Ortholog(s) have RNA binding activity, role in rRNA processing and ribosome localization CAALFM_C101910WA Protein of unknown function; present in exponential and stationary growth phase yeast cultures CAALFM_C101920WA Putative PDR-subfamily ABC transporter involved in sensitivity to azoles; Spider biofilm induced CAALFM_C101930WA Protein of unknown function; regulated by Nrg1, Tup1; Spider and flow model biofilm induced CAALFM_C101940CA Ortholog of Srp21, signal recognition particle subunit, functions in protein targeting to the endoplasmic reticulum membrane; predicted adhesin-like protein; mutants are viable CAALFM_C101950CA Ortholog(s) have role in vacuolar protein processing and endoplasmic reticulum localization CAALFM_C101970WA Protein of unknown function CAALFM_C101980WA High-affinity MFS glucose transporter; induced by progesterone, chloramphenicol, benomyl; likely essential for growth; protein newly produced during adaptation to the serum; rat catheter and Spider biofilm induced CAALFM_C101990WA Putative heat shock protein; fluconazole repressed; amphotericin B induced; Spider biofilm induced; rat catheter biofilm induced CAALFM_C102000WA Ortholog(s) have endoplasmic reticulum, nuclear pore localization CAALFM_C102010CA Predicted Zn(II)2Cys6 transcription factor; caspofungin induced; Hap43-repressed CAALFM_C102020WA Ortholog(s) have 5-formyltetrahydrofolate cyclo-ligase activity, role in folic acid-containing compound biosynthetic process and mitochondrion localization CAALFM_C102030CA Ortholog(s) have role in response to drug and cytosol, nucleus localization CAALFM_C102040CA Putative deubiquitinating enzyme; induced by Mnl1 under weak acid stress CAALFM_C102050CA Putative low-affinity phosphate transporter; fungal-specific (no human or murine homolog) CAALFM_C102060WA Predicted plasma membrane protein; gene has intron CAALFM_C102070WA Putative 30 kda heat shock protein; repressed during the mating process; rat catheter biofilm induced CAALFM_C102080WA Ortholog of S. cerevisiae Set6, a SET domain protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_C102090CA Predicted debranching enzyme-associated ribonuclease; rat catheter biofilm induced CAALFM_C102100WA Ortholog(s) have microtubule motor activity, protein homodimerization activity and kinesin complex localization CAALFM_C102110CA Putative MFS glucose transporter; 20 member C. albicans glucose transporter family; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose; rat catheter and Spider biofilm induced CAALFM_C102120CA Putative ser/thr kinase involved in glucose transport; Tn mutation affects filamentous growth; fluconazole-induced; ketoconazole-repressed; induced in by alpha pheromone in SpiderM; possibly essential; flow model biofilm induced CAALFM_C102130CA Galactokinase; galactose, Mig1, Tup1, Hap43 regulated; fluconazole, ketoconazole-induced; stationary phase enriched protein; GlcNAc-induced protein; farnesol, hypoxia-repressed in biofilm; rat catheter and Spider biofilm induced CAALFM_C102150WA UDP-glucose 4-epimerase; galactose utilization; mutant has cell wall defects and increased filamentation; GlcNAc-, fluconazole- and ketoconazole-induced; stationary phase enriched protein; rat catheter and flow model biofilm induced CAALFM_C102160WA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity and role in ER to Golgi vesicle-mediated transport, chromosome organization CAALFM_C102170CA UDP-glucose 4,6-dehydratase; role in mannosylation of cell wall proteins; mutation confers hypersensitivity to toxic ergosterol analog; overlaps orf19.3673; Spider biofilm induced CAALFM_C102180WA Putative galactose-1-phoshphate uridyl transferase; downregulated by hypoxia, upregulated by ketoconazole; macrophage/pseudohyphal-repressed CAALFM_C102190WA Ortholog of S. cerevisiae actin-binding protein Abp140; Hap43-induced; F-12/CO2 early biofilm induced CAALFM_C102200CA Ortholog(s) have Atg8 ligase activity, enzyme activator activity and role in C-terminal protein lipidation, CVT pathway, late nucleophagy, macroautophagy, mitophagy, piecemeal microautophagy of nucleus CAALFM_C102210WA Ortholog of C. dubliniensis CD36 : Cd36_02060, C. parapsilosis CDC317 : CPAR2_106200, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96322 and Debaryomyces hansenii CBS767 : DEHA2C02310g CAALFM_C102220CA Putative protein of unknown function; stationary phase enriched protein CAALFM_C102230WA Septin, required for wild-type invasive growth in vitro but not required for virulence in a mouse model of systemic infection; localizes to hyphal septum or bud neck; Asn-rich; aberrant gel mobility; phosphorylated in vitro by Gin4p CAALFM_C102240WA Ortholog(s) have Ran guanyl-nucleotide exchange factor activity, protein transporter activity CAALFM_C102250WA Putative dolichyl pyrophosphate (Dol-P-P) phosphatase; ketoconazole-induced; expression is increased in a fluconazole-resistant isolate; clade-associated gene expression; Hap43p-induced gene CAALFM_C102260CA Putative ADP-ribosylation factor GTPase activating protein, functional ortholog of S. cerevisiae GCS1; mutation affects endocytosis, hyphal growth, chemical and drug resistance, and sensitivity to cell wall inhibitors CAALFM_C102270CA Putative oxidoreductase; Spider biofilm induced CAALFM_C102280CA Putative protein phosphatase PP4 complex subunit; macrophage-induced gene CAALFM_C102290CA Ortholog(s) have protein domain specific binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization CAALFM_C102300WA Ortholog(s) have unfolded protein binding activity, role in cytoskeleton organization, positive regulation of transcription elongation from RNA polymerase II promoter, protein folding and prefoldin complex localization CAALFM_C102310CA Ortholog(s) have chromatin DNA binding activity and role in cell wall mannoprotein biosynthetic process, positive regulation of transcription from RNA polymerase II promoter, telomere maintenance via recombination CAALFM_C102320CA Putative protein similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; expression downregulated in an ssr1 null mutant CAALFM_C102330CA Ribosomal 60S subunit protein; Spider biofilm repressed CAALFM_C102350WA Component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); for protein import into mitochondria; Hap43, ketoconazole-repressed; Spider biofilm repressed CAALFM_C102360CA Putative GPI-anchored beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; fungal-specific (no human or murine homolog) CAALFM_C102370CA Ortholog of C. dubliniensis CD36 : Cd36_02210, C. parapsilosis CDC317 : CPAR2_106350, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116785 and Debaryomyces hansenii CBS767 : DEHA2C01980g CAALFM_C102380CA Ortholog(s) have role in protein folding, tubulin complex assembly and cytoplasm localization CAALFM_C102390WA Putative nuclease required for DNA single- and double-strand break repair; rat catheter biofilm induced CAALFM_C102400CA Ortholog(s) have alpha-1,2-galactosyltransferase activity, alpha-1,6-mannosyltransferase activity CAALFM_C102410CA Ortholog(s) have COPI-coated vesicle, Golgi apparatus localization CAALFM_C102420CA Essential beta-1,3-glucan synthase subunit; gsc1 allele determines resistance/sensitivity to echinocandins; 16 predicted membrane-spanning regions; mRNA abundance declines after yeast-to-hypha transition; Spider biofilm induced CAALFM_C102430CA Predicted translation initiation factor; role in translational initiation; Spider biofilm repressed CAALFM_C102440CA Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination, regulation of transcription, DNA-templated and cytoplasm, nucleus localization CAALFM_C102450CA Similar to S. cerevisiae Bud20; predicted role in cellular bud site selection; rat catheter and Spider biofilm induced CAALFM_C102460WA Ribosomal protein L10; intron in 5'-UTR; downregulated upon phagocytosis by murine macrophage; transcription regulated by yeast-hypha switch; Spider biofilm repressed CAALFM_C102470WA Ortholog of C. parapsilosis CDC317 : CPAR2_106450, C. dubliniensis CD36 : Cd36_02330, Lodderomyces elongisporus NRLL YB-4239 : LELG_01618 and Candida orthopsilosis Co 90-125 : CORT_0B07690 CAALFM_C102480WA Phosphomannomutase; enzyme of O- and N-linked mannosylation; interconverts mannose-6-phosphate and mannose-l-phosphate; functional homolog of S. cerevisiae Sec53; antigenic in mice; Hap43-induced; flow model and Spider biofilm repressed CAALFM_C102490CA Putative mitochondrial inner membrane protein with a predicted role in the assembly of respiratory complex III; Hap43p-repressed gene; S. cerevisiae ortholog FMP25 localizes to mitochondrion CAALFM_C102500WA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrion localization CAALFM_C102510WA Putative v-SNARE of the endoplasmic reticulum membrane; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C102520WA Putative cell wall protein; substrate for Kex2p processing in vitro; expression regulated by white-opaque switch; alkaline repressed; possibly essential (UAU1 method); flow model biofilm induced; Spider biofilm induced CAALFM_C102530CA Dicarboxylic amino acid permease; mutation confers hypersensitivity to toxic ergosterol analog; induced upon phagocytosis by macrophage; Gcn4-regulated; upregulated by Rim101 at pH 8; rat catheter and Spider biofilm induced CAALFM_C102570CA Putative proline permease; fungal-specific (no human or murine homolog); repressed during the mating process CAALFM_C102580WA Putative choline permease; fungal-specific (no human or murine homolog) CAALFM_C102590CA Stationary phase protein; vitamin B synthesis; induced byyeast-hypha switch, 3-AT or in azole-resistant strain overexpressing MDR1; soluble in hyphae; regulated by Gcn4, macrophage; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C102600WA Protein with a predicted role in pyridoxine metabolism; stationary phase protein; regulated by Tup1, Efg1; Spider biofilm induced CAALFM_C102610WA Putative protein with a role in autophagy; rat catheter biofilm induced CAALFM_C102620CA Putative homoserine dehydrogenase; Gcn4-regulated; induced by amino acid starvation (3-ATtreatment); macrophage-induced protein; protein level decreases in stationary phase cultures; flow model biofilm repressed CAALFM_C102630CA GPI-anchored cell wall protein, similar to S. cerevisiae exo-1,3-beta-glucosidase Exg2p; predicted Kex2p substrate; induced during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed CAALFM_C102640CA Putative mitochondrial primary import receptor CAALFM_C102650WA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide CAALFM_C102660CA Putative mitochondrial genome maintenance protein; fungal-specific (no human or murine homolog); mutation confers hypersensitivity to tubercidin (7-deazaadenosine) CAALFM_C102670CA Protein required for transfer of mannosylphosphate; induced by alpha pheromone in SpiderM medium CAALFM_C102680CA Planktonic growth-induced gene CAALFM_C102690CA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C102700CA Gene induced by hypoxia and ketoconazole; oral infection upregulated; mutants have reduced capacity to damage oral epithelial cells; Spider biofilm induced CAALFM_C102710WA Putative tRNA-Phe synthetase; downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C102720WA Putative transcription factor with zinc finger DNA-binding motif CAALFM_C102730WA Protein of unknown function; Spider biofilm induced CAALFM_C102740CA Has domain(s) with predicted NAD+ binding activity CAALFM_C102750CA Ortholog(s) have DNA translocase activity CAALFM_C102760WA Putative guanyl-nucleotide exchange factor; Spider biofilm repressed CAALFM_C102770WA Protein of unknown function; similar to human SERF2; gene has an alternatively spliced intron CAALFM_C102780WA Predicted dienelactone hydrolase domain; clade-associated gene expression; farnesol-downregulated; rat catheter biofilm repressed CAALFM_C102790WA Putative translation initiation factor eIF3, p39 subunit; mutation confers hypersensitivity to roridin A, verrucarin A; downregulated upon phagocytosis by murine macrophages; Spider biofilm repressed CAALFM_C102800WA Protein of unknown function; Spider biofilm induced CAALFM_C102810WA Ortholog of S. cerevisiae Rad16; a protein that recognizes and binds damaged DNA; flucytosine induced; rat catheter and Spider biofilm induced CAALFM_C102820WA Heterodimeric alpha-aminoadipate reductase large subunit; lysine biosynthesis; predicted binding sites for AMP and alpha-aminoadipate; inhibited by lys or thialysine; regulated by Gcn2 and Gcn4; Spider biofilm induced, flow model repressed CAALFM_C102830WA Ortholog of C. dubliniensis CD36 : Cd36_02630, C. parapsilosis CDC317 : CPAR2_108390, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115724 and Debaryomyces hansenii CBS767 : DEHA2D07986g CAALFM_C102840WA High affinity cyclic nucleotide phosphodiesterase; moderates signaling by cAMP; required for virulence, switching, cell wall, hyphal, not pseudohyphal growth; expressed shortly after hyphal induction; rat catheter and Spider biofilm induced CAALFM_C102850WA Ortholog(s) have RNA binding, flap-structured DNA binding activity and role in nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of endodeoxyribonuclease activity CAALFM_C102860CA Putative protein of the vacuolar SNARE complex; predicted role in vacuolar fusion; rat catheter biofilm repressed CAALFM_C102870WA Protein of YPT/RAB family; induced during the mating process CAALFM_C102880CA Predicted component of the mitochondrial intermembrane space import machinery; Hap43p-repressed gene CAALFM_C102890CA Protein of unknown function; Hap43-repressed gene CAALFM_C102900CA Ortholog(s) have ATP-dependent RNA helicase activity and role in generation of catalytic spliceosome for first transesterification step, spliceosomal complex disassembly CAALFM_C102910CA Ortholog(s) have protein complex scaffold, protein kinase activator activity and role in activation of protein kinase activity, autophagosome assembly, late nucleophagy, mitophagy, pexophagy, piecemeal microautophagy of nucleus CAALFM_C102920WA Putative transcription elongation factor; cdc73 kap114 double transposon mutation affects filamentous growth; Spider biofilm repressed CAALFM_C102930CA Ortholog(s) have role in mitochondrial threonyl-tRNA aminoacylation and mitochondrion localization CAALFM_C102940CA Protein of unknown function; Hap43-repressed gene CAALFM_C102950WA Ortholog of C. dubliniensis CD36 : Cd36_02750, C. parapsilosis CDC317 : CPAR2_106015, Candida tenuis NRRL Y-1498 : CANTEDRAFT_107500 and Debaryomyces hansenii CBS767 : DEHA2D08250g CAALFM_C102960CA Ortholog(s) have role in cellular ion homeostasis, establishment or maintenance of cell polarity, mitochondrion inheritance, regulation of cardiolipin metabolic process and mitochondrial inner membrane, nucleus localization CAALFM_C102970WA Predicted aminotransferase based on S. pombe ortholog SPBC660.12c; flow model biofilm induced CAALFM_C102980WA Ortholog(s) have glyoxylate reductase activity, role in glyoxylate catabolic process and cytosol, extracellular region, mitochondrion, nucleus localization CAALFM_C102990CA Exo-1,3-beta-glucanase; 5 glycosyl hydrolase family member; affects sensitivity to chitin and glucan synthesis inhibitors; not required for yeast-to-hypha transition or for virulence in mice; Hap43-induced; Spider biofilm induced CAALFM_C103000WA Putative MFS transporter; regulated by Nrg1; macrophage/pseudohyphal-repressed; induced by alpha pheromone in SpiderM medium; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C103010WA Conserved acidic ribosomal protein; likely role in regulation of translation elongation; interacts with Rpp2B; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1Bp, Rpp2A, Rpp2B); Hap43-induced; Spider biofilm repressed CAALFM_C103020CA Putative ribosomal subunit; antigenic during murine infection; downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C103030WA Putative 40S ribosomal subunit; macrophage/pseudohyphal-induced after 16 h; Spider biofilm repressed CAALFM_C103040WA Protein of unknown function; induced by nitric oxide; rat catheter and Spider biofilm induced; sequence variation between haplotype A and haplotype B alleles within strain SC5314 CAALFM_C103050WA Ortholog(s) have cytoplasm localization CAALFM_C103060CA Protein with a predicted role in pre-rRNA processing; repressed by prostaglandins CAALFM_C103070CA Putative origin recognition complex large subunit; essential for viability; similar to S. cerevisiae Orc1p origin recognition complex subunit CAALFM_C103080CA Putative GTPase involved in mitotic exit and cytokinesis; induced under Cdc5p depletion CAALFM_C103090WA Putative ribosomal protein 10 of the 40S subunit; elicits host antibody response during infection; transcript induced during active growth; Spider biofilm repressed CAALFM_C103100WA Putative lipid-binding protein with a predicted role in calcium-dependent phospholipid-binding CAALFM_C103110WA Ortholog of S. cerevisiae ribosomal subunit, Rpl6B; transposon mutation affects filamentous growth; translation-related genes are downregulated upon phagocytosis by murine macrophage; Hap43-induced; Spider biofilm repressed CAALFM_C103120WA Ortholog(s) have fungal-type vacuole localization CAALFM_C103130CA Protein involved in Golgi trafficking; rat catheter and Spider biofilm repressed CAALFM_C103140WA Ortholog(s) have role in endosome organization, regulation of protein localization and BLOC-1 complex localization CAALFM_C103150CA Ortholog of C. dubliniensis CD36 : Cd36_02950, C. parapsilosis CDC317 : CPAR2_108520, Candida tenuis NRRL Y-1498 : CANTEDRAFT_100285 and Debaryomyces hansenii CBS767 : DEHA2G15774g CAALFM_C103160CA Protein with a putative role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage; Hap43p-repressed gene CAALFM_C103170CA Ortholog(s) have nucleus-vacuole junction localization CAALFM_C103180WA Putative lipoyl ligase; role in modification of mitochondrial enzymes by attachment of lipoic acid groups; rat catheter biofilm induced CAALFM_C103190CA GPI-anchored cell wall protein; mutants show cell-wall defects and reduced adhesion, host cell damage, and endocytosis; mutant infection is immunoprotective in murine model; fluconazole-induced; caspofungin repressed CAALFM_C103200CA Zn(II)2Cys6 transcription factor; transcriptional activator of aromatic amino acid catabolism; regulator of aromatic alcohol biosynthesis via the Ehrlich pathway; mutant is viable CAALFM_C103210CA Septin; essential for viability; forms ring at sites of cell division and also forms filaments in mature chlamydospore; filamentous growth induced; regulated by Nrg1, Tup1, tyrosol and cell density; rat catheter biofilm repressed CAALFM_C103220CA Sole 14-3-3 protein in C. albicans; role in hyphal growth; possibly regulated by host interaction; localizes to yeast-form cell surface, not hyphae; alternatively spliced 5' UTR intron; Spider biofilm repressed CAALFM_C103230CA Putative ribosomal large subunit biogenesis protein; repressed in core stress response; repressed by prostaglandins CAALFM_C103240WA Ortholog(s) have cytosol, nucleus localization CAALFM_C103250CA Putative histone methyltransferase; induced by nitric oxide independent of Yhb1p; cell-cycle regulated periodic mRNA expression CAALFM_C103260WA Putative DNA-dependent ATPase; transcription may be increased in an azole-resistant strain that overexpresses MDR1 CAALFM_C103270WA Putative protein of unknown function; Hap43-repressed gene; Spider biofilm induced CAALFM_C103280WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C103290WA Ortholog(s) have histone acetyltransferase activity and role in histone acetylation, regulation of transcription from RNA polymerase II promoter CAALFM_C103300CA Putative mitochondrial processing protease; Hap43-repressed; transcript regulated by Nrg1; oxidative stress-induced via Cap1 CAALFM_C103310WA Putative DNA translocase; Spider biofilm repressed CAALFM_C103320CA Predicted 3-hydroxyisobutyryl-CoA hydrolase; mitochondrially localized; Spider biofilm induced CAALFM_C103330CA Ortholog(s) have phosphatidylinositol-3,5-bisphosphate binding activity CAALFM_C103340CA Putative endoplasmic reticulum (ER) protein-translocation complex subunit CAALFM_C103350CA Member of RNase L inhibitor (RLI) subfamily of ABC family; predicted not to be a transporter; regulated by Sef1p, Sfu1p, and Hap43p CAALFM_C103360WA Ortholog(s) have ATP-dependent DNA helicase activity, chromatin DNA binding, methylated histone binding, nucleosome-dependent ATPase activity, rDNA binding activity CAALFM_C103370WA Putative poly(A)-binding protein; regulated by Gcn4p; induced in response to amino acid starvation (3-AT treatment); protein present in exponential and stationary growth phase yeast cultures CAALFM_C103380WA Trehalose-6-phosphate (Tre6P) phosphatase; mutant heat sensitive, accumulates Tre6P, decreased mouse virulence; possible drug target; 2 conserved phospohydrolase motifs; no mammalian homolog; Hap43-repressed; flow model biofilm induced CAALFM_C103390WA Putative acyl-coenzymeA:ethanol O-acyltransferase; regulated by Sef1, Sfu1, and Hap43; induced by alpha pheromone in SpiderM medium; Spider biofilm induced; promoter bound by Ndt80 CAALFM_C103400WA Ortholog(s) have ubiquitin protein ligase binding activity CAALFM_C103410WA Protein of unknown function; Hap43-induced; rat catheter biofilm induced CAALFM_C103430WA Ortholog(s) have triglyceride lipase activity, role in triglyceride catabolic process and mitochondrion localization CAALFM_C103440CA Predicted aldehyde dehydrogenase domain; virulence-group-correlated expression CAALFM_C103450CA Protein kinase-related protein, required for normal sensitivity to caspofungin CAALFM_C103460CA Protein of unknown function; repressed by alpha pheromone in SpiderM medium CAALFM_C103470CA Ortholog(s) have protein kinase activity, role in ascospore wall assembly, protein phosphorylation and cell division site, cytosol, nucleus localization CAALFM_C103480CA Putative GTPase activator; induced in low iron; rat catheter biofilm repressed CAALFM_C103490WA Protein of unknown function; S. pombe ortholog SPAC17A2.02c plays a role in resistance to cadmium; colony morphology-related gene regulation by Ssn6; Spider biofilm repressed CAALFM_C103500WA Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles CAALFM_C103510CA Protein of unknown function; present in exponential and stationary phase yeast; identified in extracts from biofilm and planktonic cells; flow model biofilm induced gene; GlcNAc-induced protein CAALFM_C103520WA Putative non-ATPase regulatory subunit of the 26S proteasome lid; amphotericin B repressed; oxidative stress-induced via Cap1p CAALFM_C103530WA Putative RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C103540CA Ortholog(s) have role in mitochondrial genome maintenance and endoplasmic reticulum localization CAALFM_C103550CA Ortholog(s) have oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen activity CAALFM_C103560CA Transcription factor TFIIB; required for transcription initiation and start site selection by RNA polymerase II; downregulated during planktonic growth, whereas related SUA72 is induced; induced by Tbf1; rat catheter, Spider biofilm induced CAALFM_C103580WA ORF added to Assembly 21 based on comparative genome analysis; overlaps orf19.3059.2, which is annotated as a blocked reading frame CAALFM_C103600WA OPutative dolichyl-diphosphooligosaccharide-protein glycotransferase; role in protein N-linked glycosylation; Spider biofilm repressed CAALFM_C103610CA Predicted subunit of the mitochondrial inner membrane peptidase complex involved in protein targeting to mitochondria CAALFM_C103620CA Ortholog of S. cerevisiae Rps22Ap and Rps22Bp; gene contains 5' UTR intron CAALFM_C103630WA Ortholog(s) have ASTRA complex, mitochondrion localization CAALFM_C103640CA HAP5-like; ortholog of S. cerevisiae Dpb3; third-largest subunit of DNA polymerase II (DNA polymerase epsilon); phosphorylated protein; mutants have a growth defect CAALFM_C103650CA Putative 60S ribosomal protein L27, mitochondrial precursor CAALFM_C103660WA Ortholog of C. parapsilosis CDC317 : CPAR2_108915, Candida tenuis NRRL Y-1498 : CANTEDRAFT_102387, Debaryomyces hansenii CBS767 : DEHA2B06776g and Pichia stipitis Pignal : psti_CGOB_00149 CAALFM_C103670CA Putative D-amino acid oxidase; transcription is regulated upon yeast-hyphal switch CAALFM_C103680WA Endo-1,3-beta-glucanase; ortholog of S. cerevisiae Dse4 needed for cell separation; caspofungin, fluconazole repressed; repressed by alpha pheromone in SpiderM medium; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C103690WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, protein secretion and COPII vesicle coat, Golgi membrane, cis-Golgi network localization CAALFM_C103710CA Putative regulator of transcription; expression in S. cerevisiae flo8 and flo11 mutants suggests a role in regulation of adhesion factors CAALFM_C103720CA Protein of unknown function; rat catheter biofilm repressed CAALFM_C103730CA Alpha-1,2-mannosidase; processes Man9GlcNAc2 to Man8GlcNAc2 isomer B; member of ER localized glycosyl hydrolase family 47; ER form is converted by Kex2 to cytosolic form; flow model biofilm repressed CAALFM_C103740WA Zn(II)2Cys6 transcription factor; plays a role in resistance to weak organic acids; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C103750WA Protein with a predicted cytochrome b5-like Heme/Steroid binding domain; Hap43, caspofungin repressed; flow model biofilm induced CAALFM_C103760CA Ortholog(s) have cystathionine gamma-synthase activity, role in transsulfuration and cytosol, nucleus localization CAALFM_C103770WA bZIP transcription factor; involved in cell wall damage response; represses the yeast-to-hypha transition; mutants are caspofungin sensitive; induced by osmotic stress via Hog1; induced by Mnl1 under weak acid stress CAALFM_C103780CA HMG-CoA reductase; enzyme of sterol pathway; inhibited by lovastatin; gene not transcriptionally regulated in response to lovastatin and fluconazole CAALFM_C103790CA Putative peptidyl-prolyl cis-trans isomerase CAALFM_C103800WA Putative ortholog of S. cerevisiae Rpp1; subunit of both RNase MRP and nuclear RNase P; rat catheter and Spider biofilm induced CAALFM_C103810CA Elongin A; F-box protein; ubiquitin-protein ligase; role in protein ubiquitination and ubiquitin-dependent protein catabolism; rat catheter biofilm induced CAALFM_C103820WA Phosphatidylinositol transfer protein; induction correlates with CDR1, CDR2 overexpression/azole resistance; fluphenazine, 17-beta-estradiol, ethynyl estradiol, NO induced; farnesol-downregulated in biofilm; rat catheter biofilm induced CAALFM_C103830CA Ortholog(s) have role in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C103840WA Ortholog of C. dubliniensis CD36 : Cd36_03580, C. parapsilosis CDC317 : CPAR2_105090, Candida tenuis NRRL Y-1498 : CANTEDRAFT_106351 and Debaryomyces hansenii CBS767 : DEHA2A09548g CAALFM_C103860CA Protein required for wild-type cell wall chitin distribution, morphology, hyphal growth; not essential; similar to S. cerevisiae Bni4p (targeting subunit for Glc7p phosphatase, involved in bud-neck localization of chitin synthase III) CAALFM_C103870CA Predicted heme-binding stress-related protein; Tn mutation affects filamentous growth; induced during chlamydospore formation in C. albicans and C. dubliniensis; Spider biofilm induced CAALFM_C103880CA Ortholog of Candida albicans WO-1 : CAWG_01005 CAALFM_C103890WA Ortholog of Candida albicans WO-1 : CAWG_01004 CAALFM_C103900WA Similar to delta subunit of tRNA splicing endonuclease; increased transcription is observed upon fluphenazine treatment CAALFM_C103910CA Protein of unknown function; Spider biofilm induced CAALFM_C103920CA Ortholog(s) have protein-cysteine S-palmitoyltransferase activity and role in protein palmitoylation, protein targeting to membrane CAALFM_C103930WA Ortholog of C. dubliniensis CD36 : Cd36_03660, C. parapsilosis CDC317 : CPAR2_106860, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96694 and Debaryomyces hansenii CBS767 : DEHA2G15950g CAALFM_C103940WA Putative succinate dehydrogenase; localized to the mitochondrial membrane; Hap43p-repressed gene CAALFM_C103950CA Protein of unknown function; Hap43-repressed gene CAALFM_C103960CA Ortholog(s) have role in TOR signaling, protein targeting to vacuole, re-entry into mitotic cell cycle after pheromone arrest and endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment localization CAALFM_C103980WA Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C103990WA Ortholog(s) have proteasome binding activity, role in cellular response to arsenic-containing substance, proteasome-mediated ubiquitin-dependent protein catabolic process and cytoplasm, nucleus localization CAALFM_C104000CA Mannosyltransferase; induced during cell wall regeneration; fungal-specific (no human or murine homolog); Bcr1-repressed in RPMI a/a biofilms CAALFM_C104010CA Protein with a NADP-dependent oxidoreductase domain; transcript induced by ketoconazole; rat catheter and Spider biofilm induced CAALFM_C104020CA Aldo-keto reductase; role in fibronectin adhesion, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C104030WA Ortholog(s) have aspartate-tRNA ligase activity, role in mitochondrial aspartyl-tRNA aminoacylation and mitochondrion localization CAALFM_C104040CA Putative U3-containing 90S preribosome subunit; Hap43-induced; repressed in core stress response; Spider biofilm induced CAALFM_C104050CA Alpha factor mating pheromone precursor; three copies of pheromone that are proteolytically processed by Kex2p and possibly by Orf19.5851p; required for alpha cells to mate; expressed specifically in opaque phase MTLalpha/MTLalpha cells CAALFM_C104060WA Protein of unknown function; constitutive expression independent of MTL or white-opaque status CAALFM_C104070CA Ortholog(s) have Rab geranylgeranyltransferase activity and role in ER to Golgi vesicle-mediated transport, protein geranylgeranylation, protein targeting to membrane CAALFM_C104080WA Protein required for the spindle assembly checkpoint of the cell cycle; necessary for survival in host cell macrophages and for virulence in a mouse model of systemic candidiasis CAALFM_C104090CA Ortholog(s) have role in positive regulation of DNA-templated transcription, elongation, positive regulation of transcription from RNA polymerase I promoter, positive regulation of translational fidelity, protein phosphorylation CAALFM_C104100CA Mitochondrial outer membrane porin; in detergent-resistant membrane fraction (possible lipid raft component); antigenic in human, mouse; Hap43p-induced; flucytosine-, macrophage-, farnesol- induced; fluconazole, caspofungin repressed CAALFM_C104110WA Ortholog(s) have lysophosphatidic acid acyltransferase activity, role in cellular triglyceride homeostasis, lipid particle organization, protein targeting to vacuole and Golgi apparatus, endoplasmic reticulum, lipid particle localization CAALFM_C104120CA Putative U2 snRNP protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C104130WA Protein with a predicted role in ribosomal large subunit biogenesis; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); hyphal, macrophage repressed CAALFM_C104140WA Aldo-keto reductase; similar to aryl alcohol dehydrogenases; protein increase correlates with MDR1 overexpression (not CDR1 or CDR2) in fluconazole-resistant clinical isolates; farnesol regulated; possibly essential; Spider biofilm induced CAALFM_C104150CA Predicted NUDIX hydrolase domain; Hap43-induced CAALFM_C104160CA Ortholog of S. cerevisiae : YMR087W, C. glabrata CBS138 : CAGL0J01397g, C. dubliniensis CD36 : Cd36_03920, C. parapsilosis CDC317 : CPAR2_107150 and Pichia stipitis Pignal : PICST_61741 CAALFM_C104170CA Putative histone H2A; farnesol regulated; rat catheter biofilm repressed; Spider biofilm repressed; Hap43-induced CAALFM_C104180WA Predicted histone H2B; Hap43-induced gene; Spider biofilm repressed CAALFM_C104190CA Ortholog(s) have phosphatidylinositol deacylase activity CAALFM_C104200CA Ortholog(s) have structural constituent of nuclear pore activity CAALFM_C104210CA Septin; essential for viability; functional homolog of S. cerevisiae Cdc3p; down-regulation associated with azole resistance; macrophage/pseudohyphal-repressed; virulence-group-correlated expression; gene has intron CAALFM_C104220CA Ortholog of C. dubliniensis CD36 : Cd36_03980, C. parapsilosis CDC317 : CPAR2_107050, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113999 and Debaryomyces hansenii CBS767 : DEHA2D12518g CAALFM_C104230WA Ortholog(s) have ubiquitin binding activity, role in ubiquitin-dependent protein catabolic process and proteasome regulatory particle, lid subcomplex, proteasome storage granule localization CAALFM_C104240CA Putative histone H4; repressed in fkh2 mutant; regulated by Efg1; fluconazole induced; amphotericin B repressed; farnesol regulated; colony morphology-related gene regulation by Ssn6; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_C104260WA Putative histone H3; amphotericin B repressed; regulated by Efg1, farnesol; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_C104270CA Ortholog of C. dubliniensis CD36 : Cd36_04020, C. parapsilosis CDC317 : CPAR2_107000, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113990 and Pichia stipitis Pignal : PICST_32780 CAALFM_C104280CA Ortholog(s) have dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity and role in GPI anchor biosynthetic process CAALFM_C104290CA Acetyl-CoA synthetase; antigenic during human and murine infection; induced by Efg1; macrophage-induced protein; soluble protein in hyphae; gene contains intron; flow model and Spider biofilm repressed CAALFM_C104300CA HSP70 family chaperone; cell wall fractions; antigenic; beta-defensin peptides impport; ATPase domain binds histatin 5; at hyphal surface, not yeast; farnesol-repressed in biofilm; flow model, Spider biofilm repressed; caspofungin repressed CAALFM_C104310CA Protein induced by N-acetylglucosamine (GlcNAc); localized in cytoplasm; mutation causes increased resistance to nikkomycin Z CAALFM_C104320WA Putative phosphoglycerate mutase; repressed in hyphae; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C104330WA C2H2 transcription factor; putative regulator of proteasome genes; DNA recognition sequence (GAAGGCAAAA) enriched in regions upstream of proteasome genes; induced in core stress response; Hap43-induced; Spider biofilm induced CAALFM_C104340CA Ortholog(s) have cytoplasm localization CAALFM_C104350CA Protein of unknown function; Hap43-induced gene CAALFM_C104360CA Has domain(s) with predicted ATPase inhibitor activity, role in negative regulation of ATPase activity, negative regulation of nucleotide metabolic process and mitochondrion localization CAALFM_C104370CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C104380WA Serine/threonine protein phosphatase catalytic subunit; has a role in cell wall maintenance, hyphal growth, and virulence in a mouse systemic infection model CAALFM_C104390CA Putative nucleolar protein; Hap43-induced; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); represses in core stress response CAALFM_C104400CA Neutral arginine, alanine, leucine specific metallo-aminopeptidase; purified from cell wall/intracellular fractions; protein repressed during mating; Hog1, farnesol-induced; may be essential (UAU1 method); rat catheter biofilm repressed CAALFM_C104410CA Prolyl isomerase (parvulin class); essential; involved in yeast-hyphal switching, Cph1p pathway; has inflexible linker between WW and isomerase domains, unlike human homolog; functional homolog of S. cerevisiae Ess1p CAALFM_C104420CA Ortholog(s) have adenylate kinase activity, uridylate kinase activity, role in 'de novo' pyrimidine nucleobase biosynthetic process and cytosol, mitochondrion, nucleus localization CAALFM_C104430CA Putative protein of unknown function; clade-associated gene expression CAALFM_C104440WA Ortholog of Candida albicans WO-1 : CAWG_00951 CAALFM_C104450CA Putative oxidoreductase; induced by ciclopirox olamine; upregulation correlates with clinical development of fluconazole resistance; Spider biofilm repressed CAALFM_C104460CA Putative protein of unknown function, transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced CAALFM_C104470CA Protein of unknown function; transcript detected in high-resolution tiling arrays; transcription induced by alpha pheromone in SpiderM medium; Spider and early-stage flow model biofilm induced CAALFM_C104480CA Putative guanine nucleotide exchange factor; induced by Mnl1 under weak acid stress; Spider biofilm induced CAALFM_C104490WA Ortholog(s) have role in CENP-A containing nucleosome assembly, chromatin maintenance, chromatin silencing at centromere, mitotic sister chromatid segregation and nucleoplasm localization CAALFM_C104500WA Isocitrate lyase; glyoxylate cycle enzyme; required for virulence in mice; induced upon phagocytosis by macrophage; farnesol regulated; Pex5-dependent peroxisomal localization; stationary phase enriched; rat catheter, Spider biofilm induced CAALFM_C104510WA Putative transcription factor with bZIP DNA-binding motif; rat catheter biofilm induced CAALFM_C104520CA Functional homolog of S. cerevisiae Pho85p, a cyclin-dependent kinase that regulates transcription of PHO genes involved in phosphate metabolism; necessary for geldanamycin-induced filamentation; gene has intron CAALFM_C104530CA Putative tRNA U44 2'-O-methyltransferase; virulence-group-correlated expression; induced during oral infection; mutants have reduced ability to damage oral epithelial cells; early-stage flow model biofilm induced CAALFM_C104540CA Protein similar to S. cerevisiae Vps16p, which is involved in protein-vacuolar targeting; likely to be essential for growth, based on insertional mutagenesis; downregulated in biofilm or in azole-resistant strain that overexpresses MDR1 CAALFM_C104550WA Putative elongin C; transcript regulated by Nrg1 and Mig1; regulated by Gcn2 and Gcn4 CAALFM_C104560WA Putative transcription factor with C3HC4 zinc finger DNA-binding motif; mutants are viable CAALFM_C104570CA Protein described as having role in chromosome segregation; RNA abundance regulated by tyrosol and cell density CAALFM_C104580CA Ortholog of Rmd6 involved in S. cerevisiae sporulation; flow model biofilm induced CAALFM_C104590WA Protein of unknown function; Spider biofilm induced CAALFM_C104600CA Protein of unknown function; Spider biofilm repressed CAALFM_C104610WA ATP synthase alpha subunit; antigenic in human/mouse; at hyphal surface; ciclopirox, ketoconazole, flucytosine induced; Efg1, caspofungin repressed; may be essential; sumoylation target; stationary phase-enriched; Spider biofilm repressed CAALFM_C104620WA Ortholog of C. dubliniensis CD36 : Cd36_04370, C. parapsilosis CDC317 : CPAR2_105410, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114891 and Debaryomyces hansenii CBS767 : DEHA2D13420g CAALFM_C104630CA Ortholog(s) have role in endocytosis, retrograde vesicle-mediated transport, Golgi to ER, vacuole organization and COPI-coated vesicle, Golgi membrane, endosome localization CAALFM_C104640WA Ortholog(s) have serine hydrolase activity, triglyceride lipase activity, role in lipid homeostasis and lipid particle localization CAALFM_C104650WA High affinity spermidine transporter; expression is induced by urea; fungal-specific (no human or murine homolog); not required for virulence in a mouse intravenous model CAALFM_C104660WA Urea amidolyase; hydrolyzes urea to CO2; use of urea as N source and for hyphal switch in macrophage; regulated by Nrg1/Hap43; required for virulence; promotes mouse kidney and brain colonization; rat catheter and flow model biofilm induced CAALFM_C104670WA Hat1-Hat2 histone acetyltransferase complex subunit; involved in DNA damage repair and morphogenesis; mutations cause constitutive pseudohyphal growth, white to opaque switch, caspofungin sensitivity; rat catheter, Spider biofilm repressed CAALFM_C104680WA Eisosome component; predicted role in endocytosis; echinocandin-binding protein; localizes to cell surface of hyphae, but not yeast-form cells; Hap43, YNB biofilm induced; rat catheter biofilm repressed CAALFM_C104690CA Ortholog(s) have role in meiotic sister chromatid cohesion, protein localization to chromosome, centromeric region, reciprocal meiotic recombination, synaptonemal complex assembly CAALFM_C104700CA Ortholog of C. dubliniensis CD36 : Cd36_04450, C. parapsilosis CDC317 : CPAR2_105460, Debaryomyces hansenii CBS767 : DEHA2D07128g and Pichia stipitis Pignal : PICST_80203 CAALFM_C104710CA Protein similar to S. cerevisiae Rsa3 predicted nucleolar protein involved in maturation of pre-60S ribosomal particles; rat catheter and Spider biofilm induced CAALFM_C104720WA Ortholog of C. parapsilosis CDC317 : CPAR2_105440, Lodderomyces elongisporus NRLL YB-4239 : LELG_01504, Pichia stipitis Pignal : psti_CGOB_00118 and Candida orthopsilosis Co 90-125 : CORT_0B06660 CAALFM_C104730CA Homocitrate synthase, major isoform; lysine biosynthesis; expression increased in a fluconazole-resistant isolate; colony morphology-related gene regulation by Ssn6; ketoconazole-repressed; regulated by Gcn2, Gcn4, Hap43 CAALFM_C104740WA Aldo-keto reductase family protein; similar to aryl alcohol dehydrogenases; osmotic stress-induced, correlates with overexpression of MDR1 in fluconazole-resistant isolate; stationary phase enriched protein CAALFM_C104750WA Putative medium-chain alcohol dehydrogenase; rat catheter and Spider biofilm repressed CAALFM_C104760CA Ortholog(s) have role in signal transduction and Golgi apparatus, endoplasmic reticulum, mitochondrion, plasma membrane localization CAALFM_C104770CA C-5 sterol desaturase; introduces C-5(6) double bond into episterol; some clinical isolates show increased azole resistance and defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced CAALFM_C104780CA Ortholog(s) have clathrin-coated vesicle, cytoplasm localization CAALFM_C104790WA Small subunit of the heterodimeric cap binding complex; component of the spliceosomal commitment complex; Spider biofilm repressed CAALFM_C104800CA Ortholog of C. parapsilosis CDC317 : CPAR2_105580, C. dubliniensis CD36 : Cd36_04550, Lodderomyces elongisporus NRLL YB-4239 : LELG_03202 and Candida orthopsilosis Co 90-125 : CORT_0B06800 CAALFM_C104810WA Putative homolog of S. cerevisiae Tco89p, which is a component of the TOR C1 complex that is involved in the regulation of growth and cell wall integrity; heterozygous null mutant displays sensitivity to rapamycin CAALFM_C104820CA Ortholog(s) have role in ribosome biogenesis and mitochondrion localization CAALFM_C104830WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER and COPI vesicle coat, endosome localization CAALFM_C104840CA Ortholog(s) have signal sequence binding activity, role in vacuolar transport and late endosome localization CAALFM_C104860WA Ortholog of S. cerevisiae : YPR089W, C. glabrata CBS138 : CAGL0K08008g, C. dubliniensis CD36 : Cd36_04600, C. parapsilosis CDC317 : CPAR2_105630 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_129373 CAALFM_C104870WA Pepstatin A-insensitive secreted aspartyl protease; self-processing; expressed in human oral infection; Ssn6p-regulated; role in murine intravenous infection; induced during, but not required for, murine vaginal infection; N-glycosylated CAALFM_C104880CA Putative mitochondrial large subunit ribosomal protein; shows colony morphology-related gene regulation by Ssn6p CAALFM_C104890WA P-loop ATPase with similarity to human OLA1 and bacterial YchF; Spider biofilm repressed CAALFM_C104900WA Putative alpha-1,3-mannosyltransferase; predicted role in protein O-linked glycosylation; Spider biofilm induced CAALFM_C104910CA Has domain(s) with predicted methyltransferase activity and role in metabolic process CAALFM_C104930CA Ortholog of C. dubliniensis CD36 : Cd36_04660, Candida tropicalis MYA-3404 : CTRG_04484 and Candida albicans WO-1 : CAWG_00904 CAALFM_C104940CA Protein of unknown function; exogenously expressed protein is a substrate for Kex2p processing in vitro CAALFM_C104950CA Mitochondrial RNase P subunit; roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, mitochondrial translation; virulence-group-correlated expression; likely essential (UAU1 method); rat catheter biofilm induced CAALFM_C104960CA Ortholog(s) have role in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cellular response to DNA damage stimulus, cellular response to methylmercury and SCF ubiquitin ligase complex, cytosol, nucleus localization CAALFM_C104970WA Ortholog(s) have mRNA binding activity, role in cytoplasmic translational initiation and eukaryotic translation initiation factor 3 complex localization CAALFM_C104980CA Ortholog(s) have role in cellular iron ion homeostasis and mitochondrion localization CAALFM_C104990CA Ortholog(s) have role in mRNA cis splicing, via spliceosome and U2-type prespliceosome, U2AF, commitment complex, cytosol localization CAALFM_C105000WA Putative beta-mannosyltransferase required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; 9-gene family memebr; regulated on yeast-hypha and white-opaque switches; Spider biofilm repressed CAALFM_C105010CA Ortholog(s) have role in cellular zinc ion homeostasis and endoplasmic reticulum localization CAALFM_C105020CA Putative enzyme of arginine biosynthesis; transcription of genes of arginine biosynthesis pathway, except for ARG2, is induced upon phagocytosis by macrophage CAALFM_C105030CA Ortholog(s) have role in double-strand break repair via break-induced replication, mitotic DNA replication and GINS complex, cytosol, nuclear chromatin, replication fork protection complex localization CAALFM_C105050CA Putative nuclear exosome exonuclease component; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C105060WA Putative cytoplasmic pre-60S factor; Hap43-induced; repressed by prostaglandins CAALFM_C105070CA Protein involved in attachment of GPI-linked proteins to cell wall; member of major facilitator superfamily; phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi7p CAALFM_C105080WA GABA/polyamine transporter; 9 to 11 membrane spanning segments; complements GABA uptake defect of an S. cerevisiae uga4 put4 gap1 triple mutant; complements growth of an S. cerevisiae spe1 mutant under polyamine limitation CAALFM_C105090WA Transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C105100WA Protein of unknown function; clade-associated gene expression CAALFM_C105110CA 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by tyrosine if produced in S. cerevisiae Aro3p and Aro4p catalyze same reaction; protein decreases in stationary phase CAALFM_C105120WA Ortholog(s) have role in actin cortical patch localization, arginine transport, endocytosis, late endosome to vacuole transport, lysine transport, regulation of intracellular pH CAALFM_C105140WA Transcription factor; recruits Hda1 to hypha-specific promoters; Tn mutation affects filamentation; Hap43-repressed; Spider and flow model biofilm induced; required for Spider biofilm formation; Bcr1-repressed in RPMI a/a biofilms CAALFM_C105150CA Protein of unknown function CAALFM_C105160CA Putative phosphatidyl synthase; stationary phase enriched protein; transcript repressed by yeast-hypha switch; Hap43-repressed; rat catheter, Spider and flow model biofilm induced CAALFM_C105170CA Predicted ubiquitin-binding protein; rat catheter biofilm repressed CAALFM_C105180CA Protein with a NADH-ubiquinone oxidoreductase B18 subunit domain; gene has intron CAALFM_C105190CA Protein with a NADH-ubiquinone oxidoreductase B18 subunit domain; gene has intron CAALFM_C105200CA Protein of unknown function; constitutive expression independent of MTL or white-opaque status; upregulated in a cyr1 mutant CAALFM_C105210CA Protein of unknown function; repressed by prostaglandins CAALFM_C105220CA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_C105230WA Ortholog(s) have RNA polymerase III activity and role in tRNA transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase III type 2 promoter CAALFM_C105240CA Putative 26S proteasome regulatory subunit 7; Hap43p-repressed gene; regulated by Gcn2p and Gcn4p; overlaps orf19.442 CAALFM_C105250WA Ortholog of Candida guilliermondii ATCC 6260 : PGUG_05525, Candida lusitaniae ATCC 42720 : CLUG_03378 and Candida albicans WO-1 : CAWG_00876 CAALFM_C105260CA Putative mitochondrial succinate dehydrogenase; macrophage/pseudohyphal-induced; repressed by nitric oxide CAALFM_C105270CA Ortholog(s) have recombinase activity, single-stranded DNA binding, structural constituent of ribosome activity CAALFM_C105280WA Has domain(s) with predicted membrane localization CAALFM_C105290WA Putative tRNA-Gly synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein CAALFM_C105300CA Putative proteinase; transcript regulated by Nrg1, Mig1, and Tup1; Hogp-induced; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm repressed CAALFM_C105320CA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in intra-Golgi vesicle-mediated transport, protein complex assembly and TRAPPII protein complex, trans-Golgi network localization CAALFM_C105330CA Predicted SCF ubiquitin ligase complex protein; Spider biofilm induced; rat catheter biofilm induced CAALFM_C105340CA Zn(II)2Cys6 transcription factor; regulates sulfite tolerance through expression of SSU1 and CDG1; Hap43-repressed; Spider biofilm induced CAALFM_C105350WA Rab-family GTPase involved in vacuolar trafficking, colocolizes with Vps1p and Ypt52p in late endosome; Hap43-repressed gene CAALFM_C105360CA Putative non-canonical poly(A) polymerase; repressed by nitric oxide; Spider biofilm induced CAALFM_C105370CA Putative serine/threonine kinase; induced during planktonic growth; rat catheter biofilm repressed CAALFM_C105380CA Ortholog(s) have telomeric DNA binding activity CAALFM_C105390CA Ortholog of C. dubliniensis CD36 : Cd36_05120, C. parapsilosis CDC317 : CPAR2_107740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136277 and Debaryomyces hansenii CBS767 : DEHA2A02266g CAALFM_C105400CA Ortholog(s) have mitochondrial large ribosomal subunit localization CAALFM_C105410CA Putative thioredoxin peroxidase/alkyl hydroperoxide reductase; induced in low iron; regulated by Gcn4; induced in response to amino acid starvation (3-AT treatment) CAALFM_C105420WA Ortholog(s) have enzyme activator activity, mRNA binding activity, role in deadenylation-dependent decapping of nuclear-transcribed mRNA and cytoplasmic mRNA processing body, nucleus localization CAALFM_C105430WA Putative transcription factor; downregulated upon adherence to polystyrene; flucytosine repressed CAALFM_C105440CA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C105450WA Protein of unknown function CAALFM_C105460WA Putative TORC1 subunit; heterozygous null mutant displays sensitivity to rapamycin; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C105470WA Ortholog(s) have metallochaperone activity, pyridoxal phosphate binding activity, role in manganese ion transport, pyridoxal phosphate transport and mitochondrion localization CAALFM_C105480CA Ortholog of C. dubliniensis CD36 : Cd36_05200, C. parapsilosis CDC317 : CPAR2_107660, Candida tenuis NRRL Y-1498 : cten_CGOB_00159 and Debaryomyces hansenii CBS767 : DEHA2E07854g CAALFM_C105490CA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C105500WA Predicted mitochondrial small ribosomal subunit; rat catheter and Spider biofilm induced CAALFM_C105510CA Ribosomal protein S27; rat catheter and Spider biofilm induced CAALFM_C105520WA Protein of unknown function; induced by Sfu1; Spider biofilm induced CAALFM_C105530CA Protein with a role in protein translocation across membranes CAALFM_C105540CA Protein similar to GTPase regulators; induced in low iron; transcript activated by Mnl1 under weak acid stress; Hap43-, Sfu1- and Sef1-regulated; flow model biofilm induced, Spider biofilm induced CAALFM_C105560WA Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase); catalyzes the penultimate step in the synthesis of riboflavin; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_C105600WA Beta-1,3-glucan synthase subunit; 10 predicted transmembrane regions; caspofungin induced; repressed by yeast-to-hypha transition; young biofilm repressed, induced by biofilm drug exposure; Bcr1-repressed in RPMI a/a biofilms CAALFM_C105610WA Ortholog(s) have glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, role in glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation and glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion localization CAALFM_C105620CA Protein similar to S. cerevisiae Ste3p, the receptor for a-factor mating pheromone; alpha mating-type-specific transcription CAALFM_C105630CA Putative karyopherin beta; repressed by nitric oxide CAALFM_C105640CA eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; predicted nucleolar protein required for maturation of 18S rRNA; Spider biofilm induced CAALFM_C105650WA Protein with a predicted phosphoribulokinase/uridine kinase domain; Spider biofilm induced CAALFM_C105660CA Ortholog(s) have structural constituent of nuclear pore activity and role in chromosome segregation, heterochromatin assembly involved in chromatin silencing, nuclear pore complex assembly, protein targeting to nuclear inner membrane CAALFM_C105670WA Has domain(s) with predicted peptidase activity and role in proteolysis CAALFM_C105680CA Putative single-stranded DNA-binding protein; protein level decreases in stationary phase cultures; rat catheter biofilm repressed CAALFM_C105690CA Protein of unknown function; Spider biofilm induced CAALFM_C105700WA Putative autophagosome protein; macrophage/pseudohyphal-repressed; alternatively spliced intron in 5' UTR; Spider biofilm induced CAALFM_C105710CA Putative gamma-aminobutyric acid/polyamine permease; nitrogen catabolite repressed gene, induced in absence of preferred N sources; transcriptionally induced upon phagocytosis by macrophage; gene regulation by nitrogen source requires Gat1p CAALFM_C105720WA 60S ribosomal protein L7; snoRNA snR39b encoded within the 2nd intron CAALFM_C105740CA Ortholog of C. dubliniensis CD36 : Cd36_05410, C. parapsilosis CDC317 : CPAR2_107480, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94695 and Debaryomyces hansenii CBS767 : DEHA2D02288g CAALFM_C105750CA Ortholog(s) have histone demethylase activity (H3-trimethyl-K4 specific) activity CAALFM_C105760CA GPI-anchored adhesin-like protein of the cell wall; role in cell wall integrity; required for normal virulence; induced in high iron and during cell wall regeneration; Hap43-repressed CAALFM_C105770CA Putative carboxypeptidase Y precursor; transcript regulated by Nrg1 and Mig1; regulated by Gcn2 and Gcn4 CAALFM_C105780WA Putative RSC chromatin remodeling complex component; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 CAALFM_C105790WA Ortholog of C. dubliniensis CD36 : Cd36_61610, C. parapsilosis CDC317 : CPAR2_107530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115252 and Debaryomyces hansenii CBS767 : DEHA2D02200g CAALFM_C105800CA Ortholog of S. pombe replication termination factor Rtf2; Spider biofilm induced CAALFM_C105810WA Putative heterohexameric cochaperone prefoldin complex subunit; macrophage/pseudohyphal-repressed gene and macrophage-induced protein CAALFM_C105820CA Ortholog of S. cerevisiae Rad10, an endonuclease involved in nucleotide excision repair; mutant is extremely sensitive to UV irradiation; transcript repressed in alkaline conditions CAALFM_C105830WA Ortholog(s) have trans-aconitate 3-methyltransferase activity and cytosol, nucleus localization CAALFM_C105840WA Protein with similarity to pirins; induced by benomyl and in response to alpha pheromone in SpiderM medium; transcript induced by Mnl1 in weak acid stress; rat catheter and Spider biofilm induced CAALFM_C105850WA Putative subunit of DNA polymerase delta, involved in chromosomal DNA replication; cell-cycle regulated periodic mRNA expression CAALFM_C105860WA Protein similar to pirin; Hap43p-repressed gene CAALFM_C105870WA Protein similar to pirin; induced by Mnl1 under weak acid stress; Hap43-repressed; Spider biofilm induced CAALFM_C105880WA Protein with similarity to pirins; induced by benomyl treatment; flow model biofilm repressed CAALFM_C105890WA Protein of unknown function; substrate for Kex2 processing in vitro; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced; Bcr1-repressed in a/a RPMI biofilms CAALFM_C105900WA Protein of unknown function; mRNA binds to She3; Hap43 repressed gene; Spider biofilm induced CAALFM_C105910WA Protein of unknown function; flow model, rat catheter and Spider biofilm induced CAALFM_C105920WA Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Spider biofilm induced CAALFM_C105930CA Ortholog(s) have gamma-glutamyltransferase activity, omega peptidase activity, role in glutathione catabolic process and cytoplasm, glutathione hydrolase complex, nuclear periphery localization CAALFM_C105940WA Putative phosphate permease; transcript repressed by Rim101 at pH 8; regulated by white-opaque switch; caspofungin repressed; virulence-group-correlated expression; flow model biofilm induced CAALFM_C105950CA Protein of unknown function; induced in high iron; repressed in core caspofungin response; ketoconazole-repressed; colony morphology-related gene regulation by Ssn6; possibly subject to Kex2 processing CAALFM_C105960WA Putative GPI-anchored cell wall protein; repressed in core caspofungin response; Hog1-induced; regulated by Ssn6; Mob2-dependent hyphal regulation; flow model biofilm induced CAALFM_C105970WA Putative adhesin-like protein; macrophage-induced gene CAALFM_C105980WA Putative Type II phosphatidylinositol 4-kinase; Ssr1-repressed; flow model biofilm repressed CAALFM_C105990CA Ortholog(s) have cell division site, cell tip, cytoplasm, nucleus localization CAALFM_C106000WA Putative dicarboxylic amino acid permease; fungal-specific (no human or murine homolog); induced by alpha pheromone in SpiderM medium CAALFM_C106010WA Protein required for wild-type chitin synthase III activity; similar to (but not functional homolog of) S. cerevisiae Chs7p, which effects ER export of Chs3p; induced cyr1 mutant hyphae and ras1 yeast-form cells; Spider biofilm induced CAALFM_C106020WA GTPase activator protein; transcript induced in low iron; alkaline upregulated; localized to the bud emergence area in G1 phase and in the bud tip during S and G2 phases CAALFM_C106030CA Ortholog of S. cerevisiae Shg1; a COMPASS (Set1C) complex subunit that methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; repressed in an azole-resistant strain overexpressing MDR1 CAALFM_C106040WA Putative cullin subunit of E3 ubiquitin ligase complex, involved in response to DNA damage; induced by alpha pheromone in SpiderM medium CAALFM_C106050CA Ortholog(s) have ubiquinol-cytochrome-c reductase activity, role in aerobic respiration, mitochondrial electron transport, ubiquinol to cytochrome c and mitochondrial respiratory chain complex III localization CAALFM_C106060CA Putative mitochondrial acyl carrier protein involved in fatty acid biosynthesis; shows colony morphology-related gene regulation by Ssn6p; protein newly produced during adaptation to the serum CAALFM_C106070WA Ortholog(s) have mitochondrion, ribosome localization CAALFM_C106080CA Putative ARP2/3 complex subunit; shows colony morphology-related gene regulation by Ssn6p; mutation confers hypersensitivity to cytochalasin D CAALFM_C106090CA Predicted protein serine/threonine kinase; Spider biofilm induced CAALFM_C106100CA Essential HSP70 family protein; required for fluconazole resistance and calcineurin-dependent transcription; interacts with Cgr1; transcript regulated by iron; rat catheter biofilm induced; farnesol repressed in biofilm; sumoylation target CAALFM_C106110CA Putative ubiquitin-binding protein; regulated by Gcn2p and Gcn4p CAALFM_C106120CA Has domain(s) with predicted flap-structured DNA binding activity and role in double-strand break repair via single-strand annealing, removal of nonhomologous ends CAALFM_C106130CA bZIP transcription factor; role in unfolded protein response and control of morphology; transcript undergoes atypical splicing at C terminus under ER stress; induced during mating and by caspofungin; mRNA binds She3; Spider biofilm induced CAALFM_C106150WA Ortholog of Candida albicans WO-1 : CAWG_00792 CAALFM_C106160WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C106180WA Non-telomeric member of a family of telomere-proximal genes of unknown function; predicted N-terminus is extended, relative to that of other family members; overlaps orf19.2662 CAALFM_C106190CA Predicted ORF of unknown function; overlaps TLO34/orf19.2661 CAALFM_C106200WA Ortholog of Pichia stipitis Pignal : PICST_29216 and Candida albicans WO-1 : CAWG_00788 CAALFM_C106210WA Putative pyridoxal kinase; a key enzyme in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; involved in bud-site selection and genome integrity in S. cerevisiae; induced by alpha pheromone in SpiderM medium CAALFM_C106220CA Protein of unknown function; flow model biofilm induced; induced by alpha pheromone in SpiderM medium CAALFM_C106230CA Putative zinc finger transcription factor; macrophage-downregulated; flow model biofilm induced; flow model and Spider biofilm induced CAALFM_C106250WA Protein of unknown function; mutants are viable; filament induced; regulated by Nrg1, Rfg1, Tup1 CAALFM_C106260WA Putative GPI-anchored protein; adhesin-like protein CAALFM_C106270WA Predicted membrane protein; transcript repressed by ciclopirox olamine CAALFM_C106280CA Zn(II)2Cys6 transcription factor; role in hyphal extension, virulence, adherence to plastic; rat catheter biofilm induced; has a long 5'-UTR that regulates translational efficiency and controls transition to filamentous growth CAALFM_C106320WA Has domain(s) with predicted phosphatidylinositol binding activity and role in cell communication CAALFM_C106340WA Has domain(s) with predicted phosphatidylinositol binding activity and role in cell communication CAALFM_C106350WA Protein of unknown function; rat catheter biofilm repressed CAALFM_C106360WA Ortholog(s) have ribosomal protein S6 kinase activity, role in TORC1 signaling, peptidyl-serine phosphorylation, protein autophosphorylation and cytosol localization CAALFM_C106370CA Protein of unknown function; required for cohesion, adhesion, and RPMI biofilm formation; induced by alpha pheromone in white cells; fluconazole-induced; Spider biofilm induced CAALFM_C106380CA Ortholog of C. dubliniensis CD36 : Cd36_05960, C. parapsilosis CDC317 : CPAR2_301790, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112420 and Debaryomyces hansenii CBS767 : DEHA2G15290g CAALFM_C106390WA Putative ubiquitin C-terminal hydrolase; regulated by Gcn2p and Gcn4p CAALFM_C106400CA Ortholog(s) have role in mRNA splicing, via spliceosome and nucleus, transcriptionally active chromatin localization CAALFM_C106410WA Ortholog of C. dubliniensis CD36 : Cd36_05990, Candida tenuis NRRL Y-1498 : CANTEDRAFT_91852, Debaryomyces hansenii CBS767 : DEHA2G15356g and Pichia stipitis Pignal : PICST_87044 CAALFM_C106420CA Putative cohesin complex subunit; expression downregulated in an ssr1 null mutant CAALFM_C106430CA Ortholog of C. dubliniensis CD36 : Cd36_06020, C. parapsilosis CDC317 : CPAR2_803380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_91858 and Pichia stipitis Pignal : PICST_30337 CAALFM_C106440CA Protein of unknown function; Spider biofilm induced CAALFM_C106450CA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed CAALFM_C106460CA Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C106470WA Ortholog of S. cerevisiae Rpl39; a component of the 60S ribosomal subunit; Hap43-induced; Spider biofilm repressed CAALFM_C106480CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and ER to Golgi transport vesicle, Golgi apparatus, endoplasmic reticulum localization CAALFM_C106500WA Ortholog of C. dubliniensis CD36 : Cd36_06080, C. parapsilosis CDC317 : CPAR2_803360, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112428 and Debaryomyces hansenii CBS767 : DEHA2G15532g CAALFM_C106510CA Predicted MFS membrane transporter; member of the monocarboxylate porter (MCP) family; Spider biofilm induced CAALFM_C106520CA Ortholog of S. cerevisiae Bph1; a putative ortholog of human Chediak-Higashi syndrome protein and murine beige gene implicated in disease syndromes involving defective lysosomal trafficking; mutant is viable CAALFM_C106530CA Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; Spider biofilm induced CAALFM_C106540CA Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in the nucleus and cytoplasm; Spider biofilm induced CAALFM_C106550WA Putative glutamate synthase; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm repressed CAALFM_C106560WA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C106570WA Peroxisomal adenine nucleotide transporter; role in beta-oxidation of medium-chain fatty acid and peroxisome proliferation; rat catheter biofilm induced CAALFM_C106580WA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C106590CA Ortholog(s) have transcription factor activity, RNA polymerase II transcription factor binding, transcription factor activity, core RNA polymerase II binding activity CAALFM_C106600WA Ortholog(s) have eukaryotic initiation factor 4G binding, mRNA binding activity and role in cytoplasmic mRNA processing body assembly, negative regulation of translational initiation, stress granule assembly CAALFM_C106610CA Putative potassium transporter; similar to Schwanniomyces occidentalis Hak1p; amphotericin B induced; induced upon phagocytosis by macrophage; Hap43-repressed; rat catheter biofilm repressed CAALFM_C106620CA Ortholog of C. dubliniensis CD36 : Cd36_06210, Candida tropicalis MYA-3404 : CTRG_04227 and Candida albicans WO-1 : CAWG_00750 CAALFM_C106630WA Ortholog(s) have chromatin binding activity CAALFM_C106640CA Ortholog(s) have protein channel activity and role in mitochondrial outer membrane translocase complex assembly, protein targeting to mitochondrion CAALFM_C106650WA Ortholog(s) have peptide alpha-N-acetyltransferase activity, role in N-terminal peptidyl-methionine acetylation, mitochondrion inheritance, regulation of actin cytoskeleton organization and NatB complex, cytosol, nucleus localization CAALFM_C106660WA Protein of unknown function; regulated by osmotic stress via Hog1 and oxidative stress (Hog1- and Cap1-independent); induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C106670WA Ortholog of C. dubliniensis CD36 : Cd36_06250, C. parapsilosis CDC317 : CPAR2_206820, Candida tenuis NRRL Y-1498 : CANTEDRAFT_125137 and Debaryomyces hansenii CBS767 : DEHA2G13266g CAALFM_C106680WA Autophosphorylated class III phosphatidylinositol 3-kinase; required for normal vesicle transport, hyphal growth, fibroblast adherence, virulence in mouse systemic infection; growth-regulated; caspofungin and hydrogen peroxide sensitivity CAALFM_C106690WA Essential protein involved in cytokinesis; contains an SH3 domain CAALFM_C106700WA SH3-domain protein; role in barrier septum assembly involved in cell cycle cytokinesis; activates the Chs2 chitin synthase activity during cytokinesis; Spider biofilm repressed CAALFM_C106710WA Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C106720CA Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process CAALFM_C106730WA G-protein of RAC subfamily; required for embedded filamentous growth, not for serum-induced hyphal growth; dynamic localization at plasma membrane and nucleus; similar to, but not interchangeable with, Cdc42p; lacks S. cerevisiae homolog CAALFM_C106740CA Putative ortholog of S. cerevisiae Nop6; role in ribosomal small subunit biogenesis; Spider biofilm induced CAALFM_C106750WA Protein of unknown function; Spider biofilm induced CAALFM_C106770WA Ortholog(s) have endoplasmic reticulum, nuclear envelope localization CAALFM_C106780WA Predicted serine/threonine protein kinase, involved in regulation of ammonium transport; induced in core stress response; Hap43p-repressed gene CAALFM_C106790CA Putative ribosomal protein; induced upon adherence to polystyrene; Spider biofilm repressed CAALFM_C106800WA Ortholog(s) have GDP binding, RNA pyrophosphohydrolase activity, enzyme regulator activity, phosphodiesterase decapping endonuclease activity CAALFM_C106810WA Catalase; resistance to oxidative stress, neutrophils, peroxide; role in virulence; regulated by iron, ciclopirox, fluconazole, carbon source, pH, Rim101, Ssn6, Hog1, Hap43, Sfu1, Sef1, farnesol, core stress response; Spider biofilm induced CAALFM_C106820WA Ortholog of C. dubliniensis CD36 : Cd36_06390, C. parapsilosis CDC317 : CPAR2_209040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114052 and Debaryomyces hansenii CBS767 : DEHA2D14300g CAALFM_C106840CA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrion localization CAALFM_C106850WA Putative cyclin-like protein; possible Pho85 cyclin; hyphal repressed; induced by Mnl1 under weak acid stress CAALFM_C106860WA RTA domain protein; predicted role in response to stress; Spider biofilm induced CAALFM_C106870CA Ortholog of C. parapsilosis CDC317 : CPAR2_208910, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114047, Debaryomyces hansenii CBS767 : DEHA2D14388g and Pichia stipitis Pignal : PICST_37629 CAALFM_C106880CA Ortholog(s) have role in positive regulation of protein sumoylation, regulation of synaptonemal complex assembly and condensed nuclear chromosome, nucleus localization CAALFM_C106890CA Ribosomal 60S subunit protein; Spider biofilm repressed CAALFM_C106900CA Mitochondrial protein; possibly required for transamination of isoleucine; macrophage-downregulated protein abundance; rat catheter and Spider biofilm repressed CAALFM_C106910CA Ortholog(s) have role in positive regulation of transcription elongation from RNA polymerase II promoter and CCR4-NOT core complex localization CAALFM_C106920CA Ortholog of C. dubliniensis CD36 : Cd36_06470, C. parapsilosis CDC317 : CPAR2_208960, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114040 and Pichia stipitis Pignal : PICST_51125 CAALFM_C106930WA Component COPII vesicle coat; required for vesicle formation in ER to Golgi transport; predicted GPI-anchor; flow model and Spider biofilm repressed CAALFM_C106940CA Cell wall acid trehalase; catalyzes hydrolysis of the disaccharide trehalose; similar to S. cerevisiae vacuolar acid trehalase (Ath1p); Hap43p-repressed gene CAALFM_C106960WA Translation initiation factor eIF2, alpha chain; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein CAALFM_C106970CA Protein of unknown function; protein newly produced during adaptation to the serum CAALFM_C106980CA Predicted membrane transporter; monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); possibly essential, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced CAALFM_C107000WA Putative mitochondrial translation elongation factor; caspofungin induced CAALFM_C107010WA Ortholog of C. dubliniensis CD36 : Cd36_06550, C. parapsilosis CDC317 : CPAR2_209030, Candida tenuis NRRL Y-1498 : CANTEDRAFT_111035 and Debaryomyces hansenii CBS767 : DEHA2F25300g CAALFM_C107020CA Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Put3, a transcription factor involved in the regulation of proline utilization genes CAALFM_C107030CA Pry family protein; required for virulence in mouse systemic/rabbit corneal infections; not filamentation; mRNA binds She3, is localized to hyphal tips; Hap43-induced; in both yeast and hyphal culture supernatants; Spider biofilm induced CAALFM_C107040CA Pry family pathogenesis-related protein; oral infection upregulated gene; mutant has reduced capacity to damage oral epithelial cells CAALFM_C107050CA Ortholog(s) have ATP-dependent 5'-3' DNA helicase activity and DNA helicase A complex, alpha DNA polymerase:primase complex, cytosol localization CAALFM_C107060CA Ortholog of S. cerevisiae : YIL156W-B, C. glabrata CBS138 : CAGL0H06732g, C. dubliniensis CD36 : Cd36_06600, C. parapsilosis CDC317 : CPAR2_208850 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_116509 CAALFM_C107070CA Putative RNA helicase CAALFM_C107080WA Component of the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; Spider biofilm induced CAALFM_C107090CA Ortholog(s) have 3'-5'-exoribonuclease activity CAALFM_C107100CA Ortholog of C. dubliniensis CD36 : Cd36_06640, C. parapsilosis CDC317 : CPAR2_208220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136902 and Debaryomyces hansenii CBS767 : DEHA2F26730g CAALFM_C107110WA Protein similar to S. cerevisiae Taf145p, a component of RNA polymerase II transcription factor TFIID; flucytosine repressed; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C107120WA Putative amino acid permease; hyphal induced; regulated by Hap43, Gcn2 and Gcn4; colony morphology-related gene regulation by Ssnp; detected at plasma membrane of yeast and germ tube by mass spec; Spider biofilm induced CAALFM_C107130CA Protein of unknown function; Spider biofilm induced CAALFM_C107140CA Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C107150WA Ortholog of C. dubliniensis CD36 : Cd36_06690, Debaryomyces hansenii CBS767 : DEHA2F26620g, Pichia stipitis Pignal : PICST_62738 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00038 CAALFM_C107160CA Protein conserved among the CTG-clade; 2 adjacent upstream SRE-1 elements; highly up-regulated in cecum-grown cells in a Cph2-dependent manner; Hap43-repressed; rat catheter, Spider and flow model biofilm induced CAALFM_C107170CA Predicted Zn(II)2Cys6 transcription factor; ortholog of S. cerevisiae Gsm1; flow model biofilm induced CAALFM_C107180WA Copper chaperone involved in activation and protection of superoxide dismutase Sod1p CAALFM_C107190WA Leucine-rich-repeat domain protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; lacks orthologs in higher eukaryotes CAALFM_C107200WA Putative inner mitochondrial membrane transporter; flucytosine induced; Spider biofilm repressed CAALFM_C107210CA Protein similar to ammomium permeases that is probably inactive, as a mep2 mep3 double homozygous null mutation abolishes cellular ammomium permease activity; fungal-specific (no human or murine homolog) CAALFM_C107220WA Protein of unknown function; Plc1p-regulated; expression induced early upon infection of reconstituted human epithelium (RHE), while expression of the C. dubliniensis ortholog is not; mutant is viable; Spider biofilm induced CAALFM_C107230WA 4-nitrophenyl phosphatase, possible histone H2A phosphatase; involved in regulation of white-opaque switch; hyphal repressed; induced in core stress response; induced by cadmium stress via Hog1; rat catheter and Spider biofilm repressed CAALFM_C107240WA Phosphohistidine intermediate protein in a phosphorelay signal transduction pathway; residue His69 is the phosphoacceptor histidine; predicted to be soluble and cytosolic; functional homolog of S. cerevisiae Ypd1p CAALFM_C107250CA Putative mannosyltransferase; similar to S. cerevisiae Alg9p; has HKEXRF motif CAALFM_C107260CA Ortholog(s) have DNA replication origin binding, single-stranded DNA binding activity CAALFM_C107270WA Ortholog(s) have protein transporter activity and role in CVT pathway, ER to Golgi vesicle-mediated transport, macroautophagy, pexophagy, retrograde transport, vesicle recycling within Golgi CAALFM_C107280CA Ortholog(s) have role in nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, transcription from RNA polymerase II promoter and core TFIIH complex, cytosol, holo TFIIH complex localization CAALFM_C107330WA Zinc finger protein; controls meiosis in S. cerevisae; white-specific transcript; upregulation correlates with clinical development of fluconazole resistance; Upc2-regulated in hypoxia; flow model biofilm induced; Spider biofilm repressed CAALFM_C107340WA Ortholog(s) have ATPase activity, DNA binding, nucleosome binding, rDNA binding activity CAALFM_C107350CA Putative glutathione peroxidase involved in Cap1p-dependent oxidative stress response, required for Cap1p oxidation in response to H2O2; planktonic growth-induced CAALFM_C107360WA Ortholog(s) have structural constituent of cytoskeleton activity, role in microtubule nucleation and spindle pole body localization CAALFM_C107370CA Transcription factor; for mating, filamentation on solid media, pheromone-stimulated biofilms; in pathway with Ess1, Czf1; required with Efg1 for host cytokine response; regulates galactose metabolism genes; rat cathether biofilm repressed CAALFM_C107380CA Putative serine/threonine protein kinase; mRNA binds She3 and is localized to hyphal tips; mutation confers hypersensitivity to amphotericin B CAALFM_C107390WA Ortholog(s) have ubiquitin binding activity, role in proteasome-mediated ubiquitin-dependent protein catabolic process and cytoplasm, nucleus localization CAALFM_C107400CA Ortholog of C. dubliniensis CD36 : Cd36_06910, C. parapsilosis CDC317 : CPAR2_208560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95854 and Debaryomyces hansenii CBS767 : DEHA2F25982g CAALFM_C107410CA Putative subunit D of kinetochore protein complex CBF3; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) CAALFM_C107420CA Putative peroxisomal protein involved in targeting proteins into peroxisomes; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C107430WA Putative inducible acid phosphatase; DTT-extractable and observed in culture supernatant in low-phosphate conditions; slight effect on murine virulence; virulence-group-correlated expression; N-glycosylated; F-12/CO2 early biofilm induced CAALFM_C107440WA Putative glucosyltransferase; localized to the mitochondrial membrane CAALFM_C107460CA Protein similar to S. cerevisiae Gpi8p, which is a subunit of the GPI transamidase complex that adds GPI anchors to proteins; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C107470CA Putative helicase; fungal-specific (no human or murine homolog) CAALFM_C107480CA Has domain(s) with predicted ATP binding, DNA binding, helicase activity, hydrolase activity, nucleic acid binding activity CAALFM_C107490CA Ortholog(s) have DNA-directed DNA polymerase activity, role in DNA replication initiation, telomere capping and alpha DNA polymerase:primase complex, nuclear envelope localization CAALFM_C107500CA Ortholog(s) have tRNA binding activity, role in tRNA 3'-trailer cleavage, endonucleolytic and nucleolus, nucleoplasm localization CAALFM_C107510WA Putative non-specific single-domain racemase; regulated by Gcn4p; repressed in response to amino acid starvation (3-AT treatment); alkaline upregulated; macrophage-induced protein CAALFM_C107520CA Ortholog(s) have lipid binding activity and role in endoplasmic reticulum membrane organization, protein localization to plasma membrane, regulation of phosphatidylinositol dephosphorylation CAALFM_C107530WA Ortholog of Candida albicans WO-1 : CAWG_00667 CAALFM_C107540CA Putative SH3-domain-containing protein CAALFM_C107550WA Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity CAALFM_C107560WA Ortholog of C. dubliniensis CD36 : Cd36_07040, C. parapsilosis CDC317 : CPAR2_208700, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108836 and Debaryomyces hansenii CBS767 : DEHA2F25674g CAALFM_C107570CA Has domain(s) with predicted RNA binding, pseudouridine synthase activity and role in pseudouridine synthesis CAALFM_C107580CA Pry family pathogenesis-related protein; extracellular; opaque specific transcript; repressed by alpha pheromone in SpiderM medium; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C107590CA Ortholog(s) have AP-2 adaptor complex, cellular bud neck localization CAALFM_C107600WA Putative subunit of the F1F0-ATPase complex; colony morphology-related gene regulation by Ssn6; farnesol, macrophage-downregulated protein abundance; protein present in exponential and stationary yeast growth phases; Hap43-induced CAALFM_C107610CA Ortholog of C. dubliniensis CD36 : Cd36_07090, Candida tenuis NRRL Y-1498 : cten_CGOB_00237, Debaryomyces hansenii CBS767 : DEHA2F25542g and Pichia stipitis Pignal : psti_CGOB_00186 CAALFM_C107620CA Cell wall protein, putative structural component of the cell wall; mutation leads to increased chitin content, increased virulence and resistance to stresses; macrophage-induced gene CAALFM_C107630WA Ortholog(s) have glutathione disulfide oxidoreductase activity, role in cellular response to oxidative stress, response to osmotic stress and mitochondrial matrix localization CAALFM_C107640CA Protein with predicted serine/threonine kinase and tyrosine kinase domains; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C107650WA Protein of unknown function; Hap43-repressed gene CAALFM_C107660WA Protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis CAALFM_C107670WA Putative Zn(II)2Cys6 transcription factor CAALFM_C107680WA CCAAT-binding transcription factor; regulates low-iron induction of FRP1; in these conditions CBF comprises Hap43 and probably Hap2 and Hap3; possibly essential, disruptants not obtained by UAU1 method; Cap1-dependent induction in low iron CAALFM_C107690CA Ortholog(s) have nuclear export signal receptor activity, role in protein export from nucleus and nuclear membrane, nuclear periphery localization CAALFM_C107700CA GDP-mannose transporter; essential; required for glycosylation, hyphal growth; functional homolog of S. cerevisiae Vrg4p, which imports GDP-mannose from cytoplasm to Golgi for protein and lipid mannosylation; no mammalian homolog CAALFM_C107710CA Putative phosphoribosylpyrophosphate amidotransferase; flucytosine induced CAALFM_C107780WA Ortholog of C. dubliniensis CD36 : Cd36_07300, C. parapsilosis CDC317 : CPAR2_208300, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95879 and Debaryomyces hansenii CBS767 : DEHA2F26246g CAALFM_C107790CA Putative U3-containing 90S preribosome processome complex subunit; Hap43-induced gene; rat catheter and Spider biofilm induced; F-12/CO2 early biofilm induced CAALFM_C107800WA Putative mitochondrial protein; rat catheter biofilm induced CAALFM_C107810CA Has domain(s) with predicted protein heterodimerization activity CAALFM_C107820WA Ortholog of S. cerevisiae : YFR045W, C. glabrata CBS138 : CAGL0C02013g, C. dubliniensis CD36 : Cd36_07340, C. parapsilosis CDC317 : CPAR2_208340 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_116470 CAALFM_C107830CA Ortholog(s) have acetyltransferase activity, chromatin binding activity CAALFM_C107840WA Putative quinolinate phosphoribosyl transferase, involved in NAD biosynthesis; Hap43p-repressed gene CAALFM_C107850CA Ortholog(s) have APC-Cdc20 complex activity, enzyme regulator activity CAALFM_C107860WA Ortholog of C. dubliniensis CD36 : Cd36_07380 and Candida albicans WO-1 : CAWG_00634 CAALFM_C107870CA Cell wall biosynthesis protein; Hap43, caspofungin-repressed; Cyr1-induced in hyphal cells; reduced biofilm cell wall glucan in mutant; possibly essential (UAU1 method); flow model biofilm induced CAALFM_C107880CA Gamma-glutamylcysteine synthetase; glutathione synthesis, required for virulence;induced in low iron, H2O2, Cd, or presence of human neutrophils; possibly adherence-induced; Spider and F-12/CO2 biofilm induced CAALFM_C107890CA Phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced in GCN response, in contrast to S. cerevisiae ortholog CAALFM_C107900WA Secreted protein; ciclopirox olamine induced; regulated by Ssn6; induced by nitric oxide independent of Yhb1; Hap43-induced; Spider biofilm repressed CAALFM_C107910CA Ribosomal protein of the large subunit, mitochondrial; repressed in core stress response; protein present in exponential and stationary growth phase yeast cultures CAALFM_C107920WA Ortholog of C. dubliniensis CD36 : Cd36_07450, C. parapsilosis CDC317 : CPAR2_208450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116488 and Debaryomyces hansenii CBS767 : DEHA2F26114g CAALFM_C107930CA Putative membrane protein required for the retention of lumenal endoplasmic reticulum proteins; rat catheter biofilm induced CAALFM_C107950CA Putative pre-60S pre-ribosomal particle subunit; essential gene; S. cerevisiae ortholog RRP17 is essential; Hap43p-induced; rat catheter biofilm induced CAALFM_C107960WA Predicted nuclear exosome-associated nucleic acid binding protein; rat catheter and Spider biofilm induced CAALFM_C107970CA Putative protein kinase; role in cell wall regulation; mutant is hypersensitive to caspofungin; Spider biofilm induced CAALFM_C107980CA Ortholog of S. cerevisiae Sae3; meiosis specific protein involved in DMC1-dependent meiotic recombination in S. cerevisiae; Spider biofilm induced CAALFM_C107990CA Similar to cell-wall mannoproteins; induced in low iron; induced in cyr1 homozygous null; regulated by osmotic and oxidative stress via Hog1; Spider biofilm induced CAALFM_C108000WA Ortholog(s) have cytoplasmic stress granule, nucleolus localization CAALFM_C108010WA Dolichol-phosphate mannose synthase catalytic subunit; filament induced; Tup1-regulated; flow model and rat catheter biofilm repressed CAALFM_C108020WA Ortholog(s) have SUMO activating enzyme activity, role in protein sumoylation and SUMO activating enzyme complex localization CAALFM_C108030WA Profilin; functional homolog of S. cerevisiae Pfy1; hyphae, macrophage/pseudohyphal-induced; regulated by Nrg1, Tup1; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential CAALFM_C108040WA Ortholog of C. parapsilosis CDC317 : CPAR2_804320, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114112, Debaryomyces hansenii CBS767 : DEHA2G14938g and Candida orthopsilosis Co 90-125 : CORT_0A04360 CAALFM_C108050WA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide CAALFM_C108060WA Protein involved in regulation of white-opaque switching; Hap43-repressed gene; rat catheter biofilm repressed CAALFM_C108070WA Putative ABC transporter superfamily; fluconazole, Sfu1, Hog1, core stress response induced; caspofungin repressed; fluconazole resistance not affected by mutation or correlated with expression; rat catheter and flow model biofilm induced CAALFM_C108080CA Ortholog(s) have role in NADH oxidation, programmed cell death and mitochondrial respiratory chain complex I, membrane segment localization CAALFM_C108090CA Functional homolog of S. cerevisiae Fun12 translation initiation factor eIF5B; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C108100WA Member of the DRG family of GTP-binding proteins; involved in regulation of invasive filamentous growth CAALFM_C108110WA Ortholog(s) have nuclear localization sequence binding, protein transporter activity and role in mRNA export from nucleus, protein import into nucleus, regulation of mitotic nuclear division, regulation of protein desumoylation CAALFM_C108120WA Protein required for Spitzenkorper formation in hyphal cells (wild-type localization of Mlc1p to the Spitzenkorper); localizes to polarisome CAALFM_C108130CA Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs CAALFM_C108140WA Ortholog(s) have tRNA-specific adenosine deaminase activity, tRNA-specific adenosine-34 deaminase activity and role in adenosine to inosine editing, tRNA modification CAALFM_C108150CA Ortholog of C. parapsilosis CDC317 : CPAR2_207660.1, C. dubliniensis CD36 : Cd36_07680, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113324 and Debaryomyces hansenii CBS767 : DEHA2C11088g CAALFM_C108160WA Ortholog(s) have DNA translocase activity CAALFM_C108170CA Protein similar but not orthologous to S. cerevisiae Bul1; a protein involved in selection of substrates for ubiquitination; mutants are viable; macrophage/pseudohyphal-induced; rat catheter biofilm induced CAALFM_C108180CA Putative oxysterol-binding protein; caspofungin induced; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C108190CA Zn(II)2Cys6 transcription factor; similar to S. cerevisiae Cat8 but mutant phenotype suggests different target genes; mutant displays increased filamentous/invasive growth; flucytosine repressed; rat catheter biofilm induced CAALFM_C108200WA Protein with strong similarity to both S. cerevisiae Ntg1 and Ntg2 DNA repair glycosylases; transcript induced by iron; Hap43-repressed gene; Spider biofilm induced CAALFM_C108210CA Vacuolar membrane transporter; MRP subfamily of ABC family; may transport organic anions conjugated to glutathione, glucuronate, or sulfate; needed for virulence in mouse peritonitis; Spider biofilm induced; flow model biofilm repressed CAALFM_C108220WA Component of the Ccr4-Pop2 mRNA deadenylase; transposon mutation affects filamentous growth CAALFM_C108230CA Putative GPI-linked phospholipase B, fungal-specific (no mammalian homolog); null mutation eliminates cell-associated phospholipase A2 activity and attenuates virulence; fluconazole-repressed; flow model biofilm repressed CAALFM_C108240CA Protein with a predicted phosphoglycerate mutase family domain; Hap43-repressed; clade-associated gene expression; induced by hypoxia CAALFM_C108260CA Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Ltp1p CAALFM_C108270CA RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C108290CA Putative small ribonucleoprotein complex; Tn mutation affects filamentous growth; physically interacts with TAP-tagged Nop1; heterozygous null mutant exhibits resistance to parnafungin; Hap43-induced gene; Spider biofilm induced CAALFM_C108300WA Protein with similarity to S. cerevisiae Not5p, a member of the transcription regulatory CCR4-NOT complex; required for hyphal growth; antigenic during human oral infection; greater expression in yeast-form cells than hyphae CAALFM_C108310WA Predicted transmembrane protein; role in cell wall biogenesis; required for Cek1 phosphorylation; Spider biofilm induced CAALFM_C108320WA Putative transketolase; localizes to surface of yeast cells, not hyphae; soluble protein in hyphae; transcript regulated by Nrg1, Mig1, and Tup1; antigenic in human or murine infection; possibly essential (by UAU1 method) CAALFM_C108330CA Alcohol dehydrogenase; soluble in hyphae; expression regulated by white-opaque switching; regulated by Ssn6; indued by Mnl1 in weak acid stress; protein enriched in stationary phase yeast cultures; Spider biofilm induced CAALFM_C108340CA Sorting nexin; role in maintaining late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; Spider biofilm induced CAALFM_C108350CA Ortholog of C. dubliniensis CD36 : Cd36_02630, C. parapsilosis CDC317 : CPAR2_206910, Candida tenuis NRRL Y-1498 : cten_CGOB_00051 and Pichia stipitis Pignal : psti_CGOB_00173 CAALFM_C108360CA Fatty acid desaturase, essential protein involved in oleic acid synthesis; required for aerobic hyphal growth and chlamydospore formation; subject to hypoxic regulation; fluconazole-induced; caspofungin repressed; Hap43p-induced CAALFM_C108370WA Protein similar to S. cerevisiae Sds24 involved in cell separation during budding; transcript regulated by Mig1 and Tup1; fluconazole-induced; flow model biofilm induced CAALFM_C108380WA Translation elongation factor 1-alpha; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C108390CA Ortholog(s) have Golgi apparatus, cytosol, nucleus localization CAALFM_C108400CA Glycine decarboxylase P subunit; protein of glycine catabolism; repressed by Efg1; Hog1-induced; induced by Rim101 at acid pH; transcript induced in elevated CO2; stationary phase enriched protein CAALFM_C108410CA Putative S-adenosylmethionine-homocysteine methyltransferase; Hap43-repressed; alkaline induced; Spider biofilm repressed CAALFM_C108420WA Functional homolog of S. cerevisiae Gcr3, which acts in regulation of glycolytic genes; no intron predicted, in contrast to intron in S. cerevisiae GCR3 gene CAALFM_C108430WA ABC family protein, predicted not to be a transporter; Hap43, caspofungin repressed; rat catheter and Spider biofilm repressed CAALFM_C108440CA Protein of unknown function; Hap43-induced gene CAALFM_C108450CA Rho-type GTPase; required for budding and maintenance of hyphal growth; GGTase I geranylgeranylated; misexpression blocks hyphal growth, causes avirulence in mouse IV infection; shows actin-dependent localization to hyphal tip CAALFM_C108460CA Zn2-Cys6 transcript factor; regulator of ergosterol biosynthetic genes and sterol uptake; binds ERG2 promoter; induced by ergosterol depletion, by azoles, anaerobicity; macrophage/pseudohyphal-repressed; flow model biofilm induced CAALFM_C108470WA Ortholog(s) have role in mitochondrial respiratory chain complex III assembly and integral component of mitochondrial membrane localization CAALFM_C108480CA Component of the adaptor complex AP-3, which is involved in vacuolar protein sorting CAALFM_C108490WA Putative kynureninase; predicted role in NAD biosynthesis; Hap43-repressed gene; flow model biofilm induced CAALFM_C108500CA Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential CAALFM_C108510WA Subunit of the NuA4 histone acetyltransferase complex; Hap43-repressed; Spider biofilm repressed CAALFM_C108520CA Ortholog(s) have structural constituent of ribosome activity and cytosol, mitochondrial large ribosomal subunit, nucleus localization CAALFM_C108530WA Ortholog of C. dubliniensis CD36 : Cd36_08040, C. parapsilosis CDC317 : CPAR2_207180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114140 and Debaryomyces hansenii CBS767 : DEHA2G13992g CAALFM_C108540CA Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C108550CA HMG box mitochondrial protein; binds to mt DNA and the HWP1 promoter; mutant phenotype and functional complementation of an S. cerevisiae abf2 mutation suggest role in mt genome replication, maintenance; flow and Spider biofilm repressed CAALFM_C108560WA Chaperonin-containing T-complex subunit, induced by alpha pheromone in SpiderM medium; stationary phase enriched protein CAALFM_C108570CA Cyclin homolog; reduced expression observed upon depletion of Cln3; farnesol regulated; periodic mRNA expression, peak at cell-cycle G1/S phase; Hap43-induced; rat catheter biofilm repressed CAALFM_C108580CA Putative H+/Ca2+ antiporter; Spider biofilm repressed CAALFM_C108590CA Squalene epoxidase, epoxidation of squalene to 2,3(S)-oxidosqualene; ergosterol biosynthesis; allylamine antifungal drug target; NADH reducing cofactor but S. cerevisiae Erg1 uses NADPH; flow model biofilm induced; Spider biofilm repressed CAALFM_C108600CA Ortholog of S. cerevisiae Gcd6; catalytic epsilon subunit of the translation initiation factor eIF2B; genes encoding translation factors are repressed by phagocytosis by murine macrophages CAALFM_C108610CA Ortholog of S. cerevisiae Aim38/Rcf2, cytochrome c oxidase subunit; plasma membrane localized; Hap43-repressed; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm repressed CAALFM_C108620WA Putative low-affinity copper transporter of the vacuolar membrane; induced by nitric oxide; clade-associated gene expression; rat catheter and flow model biofilm induced CAALFM_C108630WA Ortholog(s) have RNA binding activity, role in cytoplasmic translation, mRNA processing and mitochondrion localization CAALFM_C108640WA Ortholog(s) have RNA polymerase II transcription factor activity, sequence-specific DNA binding activity, role in cellular response to oleic acid, mitochondria-nucleus signaling pathway and cytoplasm, nucleus localization CAALFM_C108650CA Ortholog(s) have ATP binding, FMN adenylyltransferase activity, magnesium ion binding activity, role in FAD biosynthetic process and cytosol, nucleus localization CAALFM_C108660CA Ortholog(s) have RNA binding activity, role in spliceosomal complex assembly and U2-type prespliceosome localization CAALFM_C108670WA Putative component of the MBF and SBF transcription complexes involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_C108680CA Ortholog(s) have 1-phosphatidylinositol 4-kinase activator activity, calcium ion binding activity CAALFM_C108690WA Ortholog(s) have role in ascospore formation, mitochondrial respiratory chain complex II assembly, positive regulation of transcription from RNA polymerase II promoter, protein-FAD linkage, tricarboxylic acid cycle CAALFM_C108700WA Ortholog(s) have role in histone deacetylation, negative regulation of meiotic nuclear division and Set3 complex localization CAALFM_C108710WA Ortholog of S. cerevisiae : YNL050C, C. glabrata CBS138 : CAGL0G01276g, C. dubliniensis CD36 : Cd36_08220, C. parapsilosis CDC317 : CPAR2_804440 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_94168 CAALFM_C108730WA Ortholog(s) have role in CVT pathway, intra-Golgi vesicle-mediated transport and Golgi transport complex localization CAALFM_C108740CA Protein with a possible role in ER to Golgi transport; induced upon yeast-hyphal switch; sumoylation target; Spider biofilm repressed CAALFM_C108750WA Putative mitochondrial carrier protein; Gcn4-regulated; F-12/ CO2 early biofilm induced; Spider biofilm induced CAALFM_C108760WA Protein of unknown function; Hap43-repressed CAALFM_C108770WA Ornithine cyclodeaminase family protein; Sef1, Sfu1, and Hap43-regulated; ortholog of S. cerevisiae YGL159W and S. pombe SPAP11E10.01; rat catheter biofilm induced CAALFM_C108780WA Ortholog(s) have alkaline phosphatase activity, role in nicotinamide nucleotide metabolic process, protein dephosphorylation and extracellular region, fungal-type vacuole membrane localization CAALFM_C108790WA Putative polyamine transporter; MFS-MDR family; induced by Sfu1, regulated upon white-opaque; decreased expression in hyphae vs yeast-form cells; regulated by Nrg1; Spider biofilm repressed CAALFM_C108800WA Ortholog(s) have role in protein folding in endoplasmic reticulum and integral component of endoplasmic reticulum membrane localization CAALFM_C108810CA Putative DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; Hap43-induced; rat catheter biofilm induced CAALFM_C108820CA Ortholog(s) have aminoacyl-tRNA hydrolase activity, role in mitochondrial translation and mitochondrion localization CAALFM_C108830CA Protein of unknown function; C. albicans- and C. dubliniensis specific gene; rat catheter biofilm repressed CAALFM_C108840WA Putative SH3-domain-containing protein CAALFM_C108850CA Putative mitochondrial ATPase of the AAA family; similar but not orthologous to S. cerevisiae Afg1; mutant is viable; regulated by Sef1, Sfu1, and Hap43 CAALFM_C108860CA Putative phosphatidylinositol 3-phosphate (PI3P) phosphatase; repressed by alpha pheromone in SpiderM medium CAALFM_C108870CA Ortholog of S. cerevisiae Jip5; predicted role in biogenesis of the large ribosomal subunit; repressed in core stress response; Hap43-induced gene CAALFM_C108880WA Putative protoporphyrinogen oxidase; involved in heme biosynthesis; predicted Kex2p substrate; iron regulated transcript; Yfh1-induced; Hap43-repressed; rat catheter biofilm repressed CAALFM_C108890CA Putative U2B'' component of the U2 snRNP, involved in splicing; contains an RNA recognition motif (RRM); ortholog of S. cerevisiae MSL1; Hap43p-induced gene CAALFM_C108900WA Protein of unknown function; hyphal-induced expression, regulated by Cyr1, Ras1, Efg1; Hap43-induced gene; Spider biofilm induced CAALFM_C108910CA Ortholog of C. dubliniensis CD36 : Cd36_08410, C. parapsilosis CDC317 : CPAR2_301700, Candida tenuis NRRL Y-1498 : cten_CGOB_00267 and Debaryomyces hansenii CBS767 : DEHA2C10560g CAALFM_C108920WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C108930CA Has domain(s) with predicted NADH dehydrogenase (ubiquinone) activity, role in electron transport chain and mitochondrial respiratory chain complex I localization CAALFM_C108940CA Zinc finger transcription factor; similar to S. cerevisiae Msn4, but not a significant stress response regulator in C. albicans; partly complements STRE-activation defect of S. cerevisiae msn2 msn4 double mutant; flow model biofilm induced CAALFM_C108950WA Putative 6-phosphofructo-2-kinase; protein repressed during the mating process CAALFM_C108980CA Glucose-6-phosphate dehydrogenase; antigenic in mice; activity induced by O2 or oxidizing agents H2O2, menadione, macrophage; caspofungin repressed; induced in core stress response; regulated by Gcn2, Gcn4; rat catheter biofilm repressed CAALFM_C108990CA Subtilisin-like protease (proprotein convertase); processes aspartyl proteinase Sap2; required for hyphal growth and wild-type virulence in mice; functional homolog of S. cerevisiae Kex2, which processes alpha-factor; Tup1-repressed CAALFM_C109000WA Ortholog of S. cerevisiae : YTP1, C. dubliniensis CD36 : Cd36_08490, C. parapsilosis CDC317 : CPAR2_801590, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109732 and Debaryomyces hansenii CBS767 : DEHA2C10384g CAALFM_C109010WA Putative cytosolic iron-sulfur (FeS) protein assembly machinery protein; induced by nitric oxide; oxidative stress-induced via Cap1p CAALFM_C109020WA Putative reductase or dehydrogenase; Hap43-repressed gene; alkaline repressed CAALFM_C109030CA Cytochrome oxidase subunit V; putative upstream CCAAT box regulatory element; macrophage/pseudohyphal-induced; repressed by nitric oxide; intron in 5'-UTR; Hap43p-dependent repression in low iron medium CAALFM_C109050WA Putative histone deacetylase, involved in regulation of white-opaque switching CAALFM_C109060CA Protein of unknown function; possibly membrane bound; mutants are viable; rat catheter biofilm repressed CAALFM_C109070WA Ortholog(s) have poly(A)-specific ribonuclease activity, role in nuclear-transcribed mRNA poly(A) tail shortening, postreplication repair and PAN complex localization CAALFM_C109080CA GPI-anchored cell wall adhesin-like protein; induced by high iron; upregulated upon Als2 depletion; mRNA binds She3 and is localized to hyphal tips; Spider biofilm repressed CAALFM_C109090CA Zn(II)2Cys6 transcription factor; required for utilization of ornithine as a nitrogen source and for wild-type resistance to caffeine; required for yeast cell adherence to silicone substrate CAALFM_C109100WA Zn(II)2Cys6 transcription factor; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C109110WA Protein of unknown function; Spider biofilm induced CAALFM_C109120WA Inositol phosphoryl transferase; catalyzes the synthesis of the most abundant sphingolipid, mannose-(inositol-P)2-ceramide, M(IP)2C, from MIPC; required for wild-type membrane localization of Cdr1; Spider biofilm induced CAALFM_C109130WA Protein of unknown function; Spider biofilm induced CAALFM_C109140CA Predicted adaptor protein involved in activation of MAP kinase-dependent signaling pathways; links response to oxidative stress to morphogenesis and cell wall biosynthesis; caspofungin repressed CAALFM_C109150WA Alternative oxidase; cyanide-resistant respiration; induced by antimycin A, oxidants; growth; Hap43, chlamydospore formation repressed; rat catheter, Spider biofilm induced; regulated in Spider biofilms by Bcr1, Tec1, Ndt80, Brg1 CAALFM_C109160WA Alternative oxidase; low abundance; constitutively expressed; one of two isoforms (Aox1p and Aox2p); involved in a cyanide-resistant respiratory pathway present in plants, protists, and some fungi, absent in S. cerevisiae; Hap43p-repressed CAALFM_C109170WA Essential transcription factor, mediates heat shock transcriptional induction; in the absence of heat stress, Cta8p levels are modulated by growth temperature to regulate basal expression of genes involved in protein folding CAALFM_C109180WA Zn(II)2Cys6 transcription factor; ortholog of S. cerevisiae Lys14 involved in the regulation of lysine biosynthesis genes CAALFM_C109190CA Putative dihydroxyacetone kinase; repressed by yeast-hypha switch; fluconazole-induced; caspofungin repressed; protein enriched in stationary phase yeast cultures; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C109200WA Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, involved in the regulation of lysine biosynthesis genes; fungal-specific CAALFM_C109210CA Putative transporter; slightly similar to the Sit1p siderophore transporter; Gcn4p-regulated; fungal-specific; induced by Mnl1p under weak acid stress CAALFM_C109220WA Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced CAALFM_C109230CA Protein similar to dihydroflavonol-4-reductases CAALFM_C109240CA Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_C109250WA Copper transporter; CPx P1-type ATPase; mediates Cu resistance; similar to Menkes and Wilson disease proteins; copper-induced; Tbf1-activated; suppresses Cu sensitivity of S. cerevisiae cup1 mutant; flow model biofilm induced CAALFM_C109260CA Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc1p; mutant shows virulence defect CAALFM_C109270WA Protein lacking an S. cerevisiae ortholog; transposon mutation affects filamentous growth; induced by by Mnl1 under weak acid stress CAALFM_C109280WA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C109290CA Arginine biosynthetic enzyme; processed in S. cerevisiae into 2 polypeptides with acetylglutamate kinase (Arg6) activity and acetylglutamate-phosphate reductase (Arg5) activity; Gcn4 regulated; alkaline repressed; Spider biofilm induced CAALFM_C109300CA Has domain(s) with predicted metal ion binding activity CAALFM_C109310CA Protein of unknown function; Spider biofilm induced CAALFM_C109320CA Protein with a regulator of G-protein signaling domain; Plc1-regulated; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C109330WA Putative ribosome-associated protein; ortholog of S. cerevisiae Tma16; Hap43-induced gene; Spider biofilm induced CAALFM_C109340CA Protein of unknown function; Sef1-, Sfu1-, and Hap43 regulated; Spider biofilm induced CAALFM_C109350WA Putative eIF-4E-binding repressor of CAP-dependent translation; stationary phase enriched protein CAALFM_C109360CA Ortholog(s) have role in establishment of protein localization to plasma membrane and mitochondrion, plasma membrane localization CAALFM_C109370WA Putative mRNA splicing factor; ortholog is essential in S. cerevisiae; Spider biofilm induced CAALFM_C109380WA Protein involved in the pH response pathway; binds to the transcription factor Rim101 and may serve as a scaffold to facilitate the C-terminal proteolytic cleavage that activates Rim101; required for alkaline pH-induced hyphal growth CAALFM_C109390WA Ortholog(s) have tRNA binding, tRNA dimethylallyltransferase activity, role in tRNA modification, transfer RNA gene-mediated silencing and cytosol, mitochondrion, nucleolus localization CAALFM_C109400CA Protein similar to S. cerevisiae Fth1p, a high affinity iron transporter for intravacuolar stores of iron; repressed by Sfu1p, amphotericin B, caspofungin; induced by alkaline pH, ciclopirox olamine; regulated by Sef1p, Sfu1p, and Hap43p CAALFM_C109420WA Secreted lipase; member of a differentially expressed lipase gene family; expressed in alimentary tract, but not oral tissue, during mouse oral infection; may have a role in nutrition and/or in creating an acidic microenvironment CAALFM_C109430WA Putative membrane protein; induced by alpha pheromone in SpiderM medium; Hap4-induced gene; Spider biofilm induced CAALFM_C109440WA Ortholog(s) have inorganic diphosphatase activity, role in aerobic respiration and mitochondrion localization CAALFM_C109450CA Putative nuclear pore complex subunit; transcript regulated by Nrg1 and Mig1 CAALFM_C109460WA Ortholog(s) have mevalonate kinase activity and role in ergosterol biosynthetic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isopentenyl diphosphate biosynthetic process, mevalonate pathway CAALFM_C109470CA Putative tricarboxylate carrier family protein; localized to the mitochondrial membrane CAALFM_C109480WA Phosphopantetheinyl transferase (PPTase); Spider biofilm induced CAALFM_C109490CA Putative GMP synthase, involved in the final step of guanine biosynthesis; soluble protein in hyphae; flucytosine induced; macrophage-downregulated protein abundance; protein level decreases in stationary phase cultures CAALFM_C109500WA Ortholog of C. dubliniensis CD36 : Cd36_08960, C. parapsilosis CDC317 : CPAR2_301680, Candida tenuis NRRL Y-1498 : cten_CGOB_00021 and Debaryomyces hansenii CBS767 : DEHA2F11088g CAALFM_C109510WA Protein similar to S. cerevisiae Ytm1p, which is involved in biogenesis of the large ribosomal subunit; transposon mutation affects filamentous growth; protein level decreases in stationary phase cultures; Hap43p-induced gene CAALFM_C109520CA Protein of unknown function; induced by nitric oxide CAALFM_C109530WA Alpha subunit of heterodimeric protein geranylgeranyltransferase type I and farnesyltransferase; a-specific transcript; lovastatin, fluconazole regulated; GGTase I binds zinc, is Mg-dependent; Cdc42 substrate; rat catheter biofilm repressed CAALFM_C109540WA Protein of unknown function; Spider biofilm induced CAALFM_C109550WA Protein of unknown function; transcript detected on high-resolution tiling arrays; rat catheter biofilm induced CAALFM_C109570WA Ortholog(s) have mitochondrion localization CAALFM_C109580CA Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment CAALFM_C109590CA Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment CAALFM_C109600CA Secreted lipase, member of family of lipase genes expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment; induced on adherence to polystyrene CAALFM_C109610WA Planktonic growth-induced gene CAALFM_C109620CA Mitochondrial matrix protein; required for assembly/stability of the F1 sector of mitochondrial F1F0 ATP synthase at high temperature; rat catheter biofilm repressed CAALFM_C109630WA Putative mitochondrial NAD-isocitrate dehydrogenase subunit 1; soluble protein in hyphae; protein level decrease in stationary phase cultures CAALFM_C109640WA Adenylosuccinate synthase; upregulated in biofilm; decreased expression in hyphae vs yeast-form cells; not induced during GCN response, in contrast to S. cerevisiae ADE12, which is induced by Gcn4p; stationary phase-enriched protein CAALFM_C109650WA WD repeat domain protein; Hap43-repressed gene; flow model biofilm induced CAALFM_C109660WA WD repeat protein; required for ubiquitin-mediated protein degradation; role in control of cellular ubiquitin levels; may promote efficient NHEJ in postdiauxic/stationary phase; Spider biofilm repressed CAALFM_C109670CA Has domain(s) with predicted DNA binding activity, role in DNA recombination, DNA repair, DNA replication and nucleus localization CAALFM_C109680WA Sphingolipid C9-methyltransferase; catalyzes methylation of the 9th carbon in the long chain base component of glucosylceramides; glucosylceramide biosynthesis is important for virulence; Spider biofilm repressed CAALFM_C109690WA Malate synthase; glyoxylate cycle enzyme; no mammalian homolog; regulated upon white-opaque switch; phagocytosis, strong oxidative stress induced; stationary phase enriched; flow model biofilm repressed; rat catheter, Spider biofilm induced CAALFM_C109700WA Ortholog of C. dubliniensis CD36 : Cd36_09140, C. parapsilosis CDC317 : CPAR2_804920, Debaryomyces hansenii CBS767 : DEHA2B10516g and Pichia stipitis Pignal : PICST_30058 CAALFM_C109710CA Ortholog(s) have role in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C109720WA Dihydroorotate dehydrogenase; de novo pyrimidine biosynthesis; regulated by yeast-hypha switch, Nrg1/Mig1/Tup1; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C109730WA Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C109740CA Ortholog of C. parapsilosis CDC317 : CPAR2_804880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_111283, Debaryomyces hansenii CBS767 : DEHA2B10604g and Pichia stipitis Pignal : PICST_40454 CAALFM_C109750WA GET complex subunit; expression downregulated in an ssr1 null mutant CAALFM_C109760CA Cytochrome c oxidase biosynthesis protein; transcript regulated by Nrg1 and Mig1 CAALFM_C109770WA Protein of unknown function; Spider biofilm induced CAALFM_C109780CA Putative iron/copper reductas; involved in iron homeostasis; rat catheter and Spider biofilm induced CAALFM_C109790CA Ortholog(s) have ATP-dependent 3'-5' RNA helicase activity, RNA binding, polynucleotide adenylyltransferase activity, protein binding, bridging activity CAALFM_C109800CA Putative integral membrane protein; fluconazole-induced CAALFM_C109810WA GlcNAc-induced protein CAALFM_C109820CA Ortholog of Candida albicans WO-1 : CAWG_00450 CAALFM_C109830WA Ortholog(s) have role in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay and Ski complex, cytosol localization CAALFM_C109840CA Protein required for localizing proteasomes to the nucleus; involved in ubiquitin-mediated protein degradation; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C109850CA Ortholog(s) have cytosol, nucleus localization CAALFM_C109860CA Protein with polyglutamate motifs and abundant Ser/Thr residues; described as a subunit of TFIIE, which is a basal transcription initiation factor of RNA Polymerase II; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C109870WA Protein with forkhead domain; similar to S. cerevisiae Hcm1p; Hap43p-induced gene CAALFM_C109880CA Bud31 ortholog; not subject to mating-type regulation, in contrast to S. cerevisiae Bud31 which has a role in specifying the bud site; Spider biofilm induced CAALFM_C109900WA Secreted lipase; gene family member whose members are expressed differentially in response to carbon source and infection; possible role in nutrition and/or in creating an acidic microenvironment; flow model biofilm induced CAALFM_C109910CA Protein with a dual-specificity phosphatase domain; Hap43-induced gene CAALFM_C109920WA Protein similar to S. cerevisiae Vps41p, which is involved in vacuole organization and biogenesis; transposon mutation affects filamentous growth; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) CAALFM_C109930WA Protein of unknown function; rat catheter biofilm repressed CAALFM_C109940WA Protein of unknown function CAALFM_C109950CA Putative integral membrane protein; S. cerevisiae ortholog Tvp23 localizes to late Golgi vesicles; rat catheter biofilm induced CAALFM_C109960WA Chaperone that facilitates the assembly of cytochrome c oxidase; plasma membrane protein CAALFM_C109970CA Homeodomain-like transcription factor; regulator of pyruvate decarboxylase; contains a putative C-terminal activation domain, Glu- and Pro-rich; complements glucose utilization defect of S. cerevisiae pdc2 mutant CAALFM_C109980CA Ortholog(s) have acylglycerol lipase activity, serine hydrolase activity, role in triglyceride metabolic process and lipid particle, mitochondrial outer membrane, plasma membrane localization CAALFM_C109990WA Putative phosphatidylinositol phosphate (PtdInsP) phosphatase, involved in cell wall integrity and morphogenesis CAALFM_C110000CA VH1 family MAPK phosphatase; regulates Cst20-Hst7-Cek1-Cph1 filamentation pathway; represses yeast-hyphal switch; required for virulence in mice; yeast-enriched; induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C110010CA Putative protein kinase with a role in control of growth and morphogenesis, required for full virulence; mutant cells are small, rounded, and sometimes binucleate; not required for filamentous growth; mutant is hypersensitive to caspofungin CAALFM_C110020WA GATA-type transcription factor; regulator of iron-responsive genes; represses iron utilization genes if iron is present; Hap43-repressed; promotes gastrointestinal commensalism in mice; Spider biofilm induced CAALFM_C110030WA Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; repressed by prostaglandins; Spider biofilm induced CAALFM_C110040WA Ortholog of S. cerevisiae Ero1; role in formation of disulfide bonds in the endoplasmic reticulum; fluconazole-induced; induced by Mnl1 under weak acid stress; Spider biofilm induced CAALFM_C110050WA Protein of unknown function; induced by Mnl1 under weak acid stress; Hap43-induced; mutant is viable CAALFM_C110060CA Protein of unknown function; transcript regulated by white-opaque switch; flow model biofilm induced; Spider biofilm induced CAALFM_C110070CA Alpha-1,2-mannosyltransferase; mutants hypersensitive to toxic ergosterol analog, amphotericin B, calcofluor white, growth at 42 degrees and have decreased cell wall mannan; flow model biofilm induced CAALFM_C110080WA Ortholog(s) have role in mRNA splicing, via spliceosome and U2-type spliceosomal complex localization CAALFM_C110090CA Protein of unknown function; Hap43-repressed; rat catheter biofilm repressed CAALFM_C110100CA Putative nuclear envelope protein; regulated by Ssn6; rat catheter biofilm repressed CAALFM_C110110WA Protein of unknown function; flow model biofilm induced CAALFM_C110120CA TFIIE small subunit; involved in RNA polymerase II transcription initiation; Spider biofilm induced CAALFM_C110140CA Protein of unknown function; S. cerevisiae ortholog Cos111 confers resistance to the antifungal drug ciclopirox olamine; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced CAALFM_C110150WA Transcription factor ('master switch') of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors CAALFM_C110160WA Putative mitochondrial phosphate transporter; caspofungin repressed; expression is increased in a fluconazole-resistant isolate; induced upon adherence to polystyrene CAALFM_C110170WA Putative adhesin-like protein; Hap43-repressed; rat catheter and Spider biofilm induced CAALFM_C110180CA Predicted regulator of endcytosis of plasma membrane proteins; fluconazole induced, alkaline induced by Rim101; repressed by caspofungin and in azole-resistant strain overexpressing MDR1; flow model, rat catheter and Spider biofilm induced CAALFM_C110190WA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_C110200CA Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced CAALFM_C110210CA Ste20p family Ser/Thr kinase required for wild-type filamentous growth, organ colonization and virulence in mouse systemic infection; role in chlamydospore formation; functional homolog of S. cerevisiae Cla4p; mutant caspofungin sensitive CAALFM_C110220CA cAMP-dependent protein kinase catalytic subunit; Tpk2 isoform; control of morphogenesis and stress response; WT nuclear localization requires Bcy1; produced during stationary, not exponential growth; rat catheter and Spider biofilm induced CAALFM_C110230CA Ortholog of C. dubliniensis CD36 : Cd36_09630, C. parapsilosis CDC317 : CPAR2_805080, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136811 and Debaryomyces hansenii CBS767 : DEHA2B12364g CAALFM_C110240CA Protein with similarity to S. cerevisiae Yer010cp, a protein of unknown function belonging to the prokaryotic RraA family; repressed by benomyl; Hap43-induced; Spider biofilm induced CAALFM_C110250CA Ortholog of C. dubliniensis CD36 : Cd36_09650, C. parapsilosis CDC317 : CPAR2_805060, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95780 and Debaryomyces hansenii CBS767 : DEHA2B12320g CAALFM_C110260CA Putative RNA polymerase I subunit; rat catheter biofilm induced CAALFM_C110270CA Putative phosphatidylinositol transporter; rat catheter and Spider biofilm repressed CAALFM_C110280CA Putative protein of unknown function; induced by prostaglandins CAALFM_C110290WA Extracellular/plasma membrane-associated glucoamylase; expressed in rat oral infection; regulated by carbohydrates, pH, galactose; promotes biofilm matrix formation; flow model biofilm induced; Bcr1 repressed in RPMI a/a biofilms CAALFM_C110300WA Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation CAALFM_C110310WA Predicted methyltransferase; Spider biofilm induced CAALFM_C110320WA Ortholog(s) have endoplasmic reticulum localization CAALFM_C110330CA Ortholog(s) have nucleosome binding activity, role in chromatin silencing at telomere, histone exchange and Swr1 complex, cytosol, nuclear chromosome, telomeric region, nuclear periphery localization CAALFM_C110340WA Putative MFS transporter; Hap43p-induced gene; also regulated by regulated by Sef1p and Sfu1p; repressed in a ssr1 null mutant CAALFM_C110350CA Putative adhesin-like protein; positively regulated by Tbf1; Spider biofilm induced CAALFM_C110360CA Putative protein of unknown function; Hap43p-repressed gene; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human/murine homolog CAALFM_C110380CA Ser/Thr kinase of cell wall integrity pathway; mutants show abnormal morphology and aggregation; Mob2p associated; required for wild-type hyphal growth and transcriptional regulation of cell-wall-associated genes CAALFM_C110390CA Putative 60S ribosomal subunit protein; colony morphology-related gene regulation by Ssn6; Spider biofilm repressed CAALFM_C110400CA Putative GPI-anchored adhesin-like protein; transposon mutation affects filamentous growth; Spider biofilm repressed CAALFM_C110410WA BED zinc finger protein; predicted DNA binding protein; Spider biofilm repressed CAALFM_C110420CA Ortholog(s) have ubiquitin protein ligase binding activity and role in positive regulation of receptor internalization, protein ubiquitination, ubiquitin-dependent endocytosis CAALFM_C110430WA Putative repressible vacuolar alkaline phosphatase; Rim101-induced transcript; regulated by Tsa1, Tsa1B in minimal media at 37 deg; possibly adherence-induced CAALFM_C110440WA Ortholog(s) have endoplasmic reticulum, ribosome localization CAALFM_C110450WA L-threonine aldolase; complements glycine auxotrophy of S. cerevisiae shm1 shm2 gly1-1 triple mutant; macrophage/pseudohyphal-induced; the GLY1 locus has an RFLP and is triploid in strain SGY269; flow model biofilm induced CAALFM_C110460WA Protein of unknown function; oral infection upregulated gene; upregulated in strains from HIV+ patients with oral candidiasis; mutants have reduced ability to damage oral epithelial cells; transcript possibly regulated upon hyphal formation CAALFM_C110470WA Mitochondrial ribosomal protein of the small subunit; Spider biofilm repressed CAALFM_C110480WA Similar to bacterial DnaJ; reported to have a role in peroxisome biogenesis; induced in low iron and upon adherence to polystyrene CAALFM_C110490WA Putative leukotriene A(4) hydrolase; repressed during the mating process; Hog1p-induced CAALFM_C110500WA Protein of unknown function; rat catheter biofilm repressed CAALFM_C110510WA Protein of unknown function; induced by Mnl1 under weak acid stress; flow model biofilm repressed CAALFM_C110520WA Protein with a predicted leucine-rich repeat domain; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C110530WA Ribosome-associated protein predicted to function in protein synthesis; 1 predicted transmembrane domain; rat catheter biofilm repressed CAALFM_C110540CA Putative adapter protein; links synaptojanins Inp52 and Inp53 to the cortical actin cytoskeleton in S. cerevisiae; mutants are viable CAALFM_C110550CA Predicted extracellular glucoamylase; induced by ketoconazole; possibly essential, disruptants not obtained by UAU1 method; promotes biofilm matrix formation; Spider biofilm induced; Bcr1-induced in RPMI a/a biofilms CAALFM_C110560CA Protein of unknown function; Hap43-repressed gene CAALFM_C110570CA Protein with predicted RNI-like domains; rat catheter biofilm induced CAALFM_C110580CA Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_C110610WA Putative transporter; Gcn4p-regulated; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases CAALFM_C110620WA Ortholog(s) have mRNA binding, pseudouridine synthase activity CAALFM_C110630CA Ortholog of C. dubliniensis CD36 : Cd36_09960, C. parapsilosis CDC317 : CPAR2_212580, Debaryomyces hansenii CBS767 : DEHA2G11770g and Pichia stipitis Pignal : PICST_51041 CAALFM_C110640CA Putative coiled-coil polarisome; predicted role in polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; rat catheter biofilm induced; sequence variation between haplotype A and haplotype B alleles within strain SC5314 CAALFM_C110650WA Putative class II abasic (AP) endonuclease; flucytosine induced CAALFM_C110660WA Transcription initiation factor; binds TATA box sequence, binding does not require TFIIA; caspofungin repressed; functional homolog of S. cerevisiae and human TATA-binding proteins; Spider biofilm induced CAALFM_C110670CA Putative RNA polymerase I subunit A190; Hap43p-induced gene; flucytosine induced CAALFM_C110680CA Predicted lipid-binding ER protein; involved in ER-plasma membrane tethering; Spider biofilm induced CAALFM_C110690WA Ortholog(s) have mitochondrion localization CAALFM_C110700CA Putative nitrilase; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures CAALFM_C110710CA Protein similar to S. cerevisiae Yor378w; MFS family transporter; transposon mutation affects filamentous growth; null mutants are viable; fungal-specific (no human or murine homolog) CAALFM_C110720CA Alpha-1,2-mannosyltransferase; similar to S. cerevisiae Mnn2; role in cell wall integrity, temperature sensitivity; iron utilization in low iron; Tn mutation affects filamentous growth; filament induced; increased chitin exposes beta-glucan CAALFM_C110730WA Putative protein of unknown function, transcription is positively regulated by Tbf1p CAALFM_C110740CA Heat shock protein; transcript regulated by cAMP, osmotic stress, ciclopirox olamine, ketoconazole; repressed by Cyr1, Ras1; colony morphology-related regulated by Ssn6; stationary phase enriched; Hap43-induced; Spider biofilm induced CAALFM_C110750CA Putative vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; added to Assembly 21 based on comparative genome analysis CAALFM_C110760WA ESCRT I protein sorting complex protein; involved in proteolytic activation of Rim101, which regulates pH response; ortholog of S. cerevisiae Stp22/Vps23 CAALFM_C110770WA Putative membrane protein; transcript regulated by Mig1; Spider biofilm induced CAALFM_C110780CA Protein with similarity to protein kinase C inhibitor-I; protein level decreases in stationary phase cultures CAALFM_C110790WA Putative microsomal ATPase; plasma membrane-localized; regulated by Gcn2 and Gcn4; induced by amino acid starvation (3-AT); macrophage/pseudohyphal-repressed; protein levels decrease in stationary phase yeast; Spider biofilm repressed CAALFM_C110800CA Cystine transporter; present in pathogenic yeasts (no human or murine homolog); Spider biofilm induced CAALFM_C110810WA Pry family pathogenesis-related protein; predicted to be extracellular CAALFM_C110820CA Putative aspartyl aminopeptidase; stationary phase enriched protein; mutation confers hypersensitivity to 5-fluorouracil (5-FU); Hog1-induced; planktonic growth-induced; rat catheter and Spider biofilm repressed CAALFM_C110830WA Endoplasmic reticulum (ER) protein; ortholog of S. cerevisiae Big1; required for beta-1,6-glucan synthesis, filamentation, adhesion, and virulence; rat catheter biofilm repressed CAALFM_C110840CA Ortholog(s) have role in retrograde transport, endosome to Golgi and cytosol, late endosome, nucleus localization CAALFM_C110850WA Ortholog of C. parapsilosis CDC317 : CPAR2_210560, C. dubliniensis CD36 : Cd36_10180, Candida orthopsilosis Co 90-125 : CORT_0A09890 and Candida tropicalis MYA-3404 : CTRG_04072 CAALFM_C110860CA Zinc finger and homeodomain transcriptional coactivator; role in cell wall integrity and in sensitivity to caspofungin; required for the normal transcriptional response to caspofungin; required for yeast cell adherence to silicone substrate CAALFM_C110870WA Ribosomal protein 17B; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed CAALFM_C110880WA Putative U3 snoRNA-associated protein; Hap43-induced; transposon mutation affects filamentous growth; repressed by prostaglandins CAALFM_C110890CA Ortholog of C. dubliniensis CD36 : Cd36_10220, C. parapsilosis CDC317 : CPAR2_210530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105553 and Debaryomyces hansenii CBS767 : DEHA2G14432g CAALFM_C110910CA Ortholog(s) have role in chromatin silencing at silent mating-type cassette, double-strand break repair via homologous recombination, intra-S DNA damage checkpoint and mitotic sister chromatid cohesion, more CAALFM_C110920WA Ortholog(s) have RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, chromatin insulator sequence binding and tDNA binding, more CAALFM_C110930CA Putative ubiquitin activating protein; Hap43-repressed; induced by prostaglandins; clade-associated gene expression CAALFM_C110940CA Protein involved in ER to Golgi transport; rat catheter and Spider biofilm repressed CAALFM_C110950CA Putative serine/threonine-protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C110960WA Ortholog(s) have inositol phosphoceramide synthase regulator activity, role in inositolphosphoceramide metabolic process and inositol phosphoceramide synthase complex, integral component of Golgi membrane localization CAALFM_C110970WA Putative nucleolar protein with a predicted role in pre-rRNA processing; Hap43-induced gene; repressed in core stress response CAALFM_C110980WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C110990CA Putative transcription factor with bZIP DNA-binding motif; mutants are sensitive to cations and antifungal drugs, and defective in filamentous growth CAALFM_C111000CA Protein with a role in nucleolar integrity and processing of pre-rRNA; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Hap43-induced; Spider biofilm induced CAALFM_C111010CA Putative ortholog of S. cerevisiae Pex32 a peroxisomal integral membrane protein with a role in negative regulation of peroxisome size; Hap43-repressed gene CAALFM_C111020WA Protein similar to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C111030WA Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C111040WA Ribosomal protein L29; induced upon germ tube formation; colony morphology-related gene regulation by Ssn6; intron in 5'-UTR; Spider biofilm repressed CAALFM_C111050WA Predicted single-stranded nucleic acid binding protein; flow model biofilm induced CAALFM_C111060CA Putative 60S ribosomal protein L2; Hap43-induced gene; repressed in infected rabbit kidney in SC5314, but not NGY152, strain background; Spider biofilm repressed CAALFM_C111070WA Protein with a predicted role in 5'-end processing of mitochondrial RNAs; ortholog of S. cerevisiae Pet127; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_C111080WA Putative 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; Hap43-repressed; flow model, rat catheter and Spider biofilm induced CAALFM_C111090CA Ortholog(s) have role in mRNA polyadenylation, pre-mRNA cleavage required for polyadenylation and cytosol, mRNA cleavage and polyadenylation specificity factor complex, nuclear chromatin localization CAALFM_C111100WA Ortholog(s) have acireductone dioxygenase (Ni2+-requiring) activity, role in L-methionine biosynthetic process from methylthioadenosine and cytosol, nucleus localization CAALFM_C111110CA Ortholog(s) have tubulin binding activity, role in tubulin complex assembly and cytoplasm, prefoldin complex localization CAALFM_C111120CA Protein similar to S. cerevisiae Gvp36p; transposon mutation affects filamentous growth CAALFM_C111130WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; fluconazole-downregulated CAALFM_C111140WA Ortholog(s) have enzyme regulator activity, role in cellular calcium ion homeostasis and integral component of endoplasmic reticulum membrane localization CAALFM_C111150WA Ortholog(s) have role in proteasome regulatory particle assembly and cytosol, nucleus localization CAALFM_C111160CA Ortholog(s) have protein tag activity and role in cell budding, cellular response to oxidative stress, invasive growth in response to glucose limitation, protein urmylation, tRNA wobble position uridine thiolation CAALFM_C111170WA Putative oligosaccharyltransferase subunit; Spider biofilm repressed CAALFM_C111190WA Putative Ras superfamily GTPase; induced by nitric oxide independent of Yhb1p CAALFM_C111200WA Predicted mucin-like protein; ketoconazole-induced; fluconazole-repressed; induced in cyr1 mutant; colony morphology-related gene regulation by Ssn6; flow model biofilm induced; Spider biofilm induced CAALFM_C111210CA CCAAT-binding factor-dependent transcription factor; repressor; also called CAP2; required for low iron response; similar to bZIP transcription factor AP-1; repressed by Sfu1; ciclopirox olamine induced; rat catheter, Spider biofilm induced CAALFM_C111220CA Predicted component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in mitochondrial protein import; Spider biofilm repressed CAALFM_C111230WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C111240CA Putative phosphatidylserine synthase; ortholog of S. cerevisiae CHO1; transposon mutation affects filamentous growth; regulated by Nrg1, Tup1 CAALFM_C111250WA Microtubule-binding protein of the cortical microtubule; delays exit from mitosis when the spindle is abnormally oriented; Spider biofilm repressed CAALFM_C111260CA Putative adhesin-like protein CAALFM_C111270WA Cell wall protein; induced in core stress response and core caspofungin response; iron-regulated; amphotericin B, ketoconazole, and hypoxia induced; regulated by Cyr1, Ssn6; induced in oralpharyngeal candidasis; Spider biofilm repressed CAALFM_C111280WA Ortholog(s) have U6 snRNA binding, pre-mRNA binding activity and role in mRNA cis splicing, via spliceosome, spliceosomal snRNP assembly CAALFM_C111290WA Has domain(s) with predicted FMN binding, catalytic activity, oxidoreductase activity and role in oxidation-reduction process CAALFM_C111300CA Ortholog(s) have RNA binding, first spliceosomal transesterification activity, role in mRNA 5'-splice site recognition and U5 snRNP localization CAALFM_C111310CA Protein repressed during the mating process CAALFM_C111320CA Protein of unknown function; hypoxia, Hap43-repressed; ketoconazole induced; induced in oralpharyngeal candidasis; 16h flow model biofilm repressed, late-stage flow model biofilm induced; rat catheter and Spider biofilm induced CAALFM_C111330CA SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins CAALFM_C111340WA Putative membrane protein with a predicted role in membrane fusion during mating; Hap43p-repressed gene; protein induced during the mating process CAALFM_C111350CA Putative fork-head transcription factor; rat catheter and Spider biofilm repressed CAALFM_C111360WA Ribosomal protein L37; Hap43-induced; Spider biofilm repressed CAALFM_C111370CA Essential protein required for the DNA integrity checkpoint pathway; Spider biofilm induced CAALFM_C111380WA Ortholog(s) have rRNA (pseudouridine) methyltransferase activity CAALFM_C111390WA Ortholog of C. dubliniensis CD36 : Cd36_10680, Debaryomyces hansenii CBS767 : DEHA2E14058g, Pichia stipitis Pignal : PICST_29620 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_146037 CAALFM_C111400CA Autophosphorylated kinase; role in pseudohyphal-hyphal switch and cytokinesis; phosphorylates Cdc11p on S395; necessary for septin ring within germ tube but not for septin band at mother cell junction; physically associates with septins CAALFM_C111410CA Predicted ORF from original SGTC Assembly 19 annotation, removed from the reduced ORF set by the SGTC; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C111420WA Putative nucleolar protein; repressed benomyl treatment or in an azole-resistant strain that overexpresses MDR1; F-12/CO2 early biofilm induced CAALFM_C111430WA Protein of unknown function; mRNA binds She3 CAALFM_C111440CA Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA replication checkpoint; ortholog of S. cerevisiae Mrc1p, an S-phase checkpoint protein; Hap43p-induced gene CAALFM_C111450CA S-adenosylmethionine synthetase; localizes to surface of hyphae, not yeast cells; alkaline, Hog1-induced; farnesol-downregulated; F-12/CO2 early biofilm induced; Spider biofilm repressed CAALFM_C111470CA Putative diacylglycerol pyrophosphate phosphatase of diacylglycerol production for phospholipid biosynthesis; downregulation correlates with clinical development of fluconazole resistance CAALFM_C111480WA High-affinity phosphate transporter; transcript regulated by white-opaque switch; Hog1, ciclopirox olamine or alkaline induced; caspofungin, stress repressed; upregulated in RHE model; Spider and flow model biofilm induced, Hap43-induced CAALFM_C111490CA Ortholog of C. dubliniensis CD36 : Cd36_10780, C. parapsilosis CDC317 : CPAR2_208080, Candida tenuis NRRL Y-1498 : CANTEDRAFT_120956 and Debaryomyces hansenii CBS767 : DEHA2F24508g CAALFM_C111500CA Putative chorismate mutase; fungal-specific (no human or murine homolog); alkaline upregulated CAALFM_C111510CA Putative DnaJ-like molecular chaperone; Spider biofilm induced CAALFM_C111520CA Zn(II)2Cys6 domain transcription factor; required for filamentous growth, resistance to rapamycin and flucytosine; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider and flow model biofilm induced CAALFM_C111530CA Ortholog(s) have sulfonate dioxygenase activity and role in sulfur compound catabolic process CAALFM_C111540CA Protein similar to S. cerevisiae Ede1p, which is involved in endocytosis; activates transcription in 1-hybrid assay in S. cerevisiae CAALFM_C111550WA Putative H/ACA snoRNP pseudouridylase complex protein; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); macrophage/pseudohyphal-induced; Spider biofilm repressed CAALFM_C111560CA Has domain(s) with predicted GTP binding activity CAALFM_C111570WA Ortholog(s) have Golgi apparatus localization CAALFM_C111580WA Protein of unknown function; transcript upregulated by benomyl treatment CAALFM_C111590WA Phospholipase D1; required for phosphatidic acid and for most diacylglycerol production; required for wild-type mouse virulence, but not rat oral virulence; mutant defect in hyphal growth on solid substrates; similar to S. cerevisiae Spo14p CAALFM_C111600WA Ortholog(s) have COPII adaptor activity and role in ER to Golgi vesicle-mediated transport, fungal-type cell wall organization, protein glycosylation, protein retention in Golgi apparatus CAALFM_C111610CA Protein similar to A. nidulans CysA serine O-trans-acetylase; suggests that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; F-12/CO2 early biofilm induced; Spider biofilm induced CAALFM_C111620WA Ortholog of S. cerevisiae Yft2 required for normal ER membrane biosynthesis; Hap43-repressed gene CAALFM_C111630CA Membrane protein required for mating; ortholog of S. cerevisiae Fus1; transcript induced by Cph1 in cells homozygous for the MTLa locus; alpha factor induced CAALFM_C111640CA Protein similar to S. cerevisiae pyrophosphate phosphatase Lpp1p; possible role in farnesol biosynthesis CAALFM_C111650WA Putative GAL4 DNA-binding enhancer protein; soluble protein in hyphae; biofilm induced; macrophage/pseudohyphal-induced; equal level of protein in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C111660WA Putative glutamate decarboxylase; alkaline, macrophage-downregulated gene; amphotericin B induced; induced by Mnl1 under weak acid stress; stationary phase enriched protein; rat catheter biofilm repressed CAALFM_C111670WA Protein of unknown function; induced in core stress response; Gcn2 and Gcn4 regulated; flow model biofilm induced; Spider biofilm induced CAALFM_C111680CA Ortholog of C. dubliniensis CD36 : Cd36_10990, C. parapsilosis CDC317 : CPAR2_804585, Candida tenuis NRRL Y-1498 : cten_CGOB_00256 and Debaryomyces hansenii CBS767 : DEHA2F10406g CAALFM_C111690WA GATA-like transcription factor; oral infection induced; mutant has reduced capacity to damage oral epithelial cells; regulated by Gcn2 and Gcn4; Spider biofilm induced CAALFM_C111700CA Putative mitochondrial respiratory protein; induced by farnesol, benomyl, nitric oxide, core stress response; oxidative stress-induced via Cap1; stationary-phase enriched protein; Spider biofilm induced CAALFM_C111710CA Ortholog of C. dubliniensis CD36 : Cd36_11020 and Candida albicans WO-1 : CAWG_00266 CAALFM_C111720WA Ortholog of Candida albicans WO-1 : CAWG_00265 CAALFM_C111730WA Protein with SEL-1 like protein domain; early-stage flow model biofilm induced CAALFM_C111740WA Ortholog of Pichia stipitis Pignal : PICST_30878, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_60017, Candida guilliermondii ATCC 6260 : PGUG_05223 and Candida tropicalis MYA-3404 : CTRG_01052 CAALFM_C111750WA Putative vacuolar transporter of large neutral amino acids; induced by alpha pheromone in SpiderM medium CAALFM_C111760CA Protein of unknown function; Spider biofilm repressed CAALFM_C111770CA Protein of unknown funtion; S. cerevisiae ortholog Svl3 plays a role in endocytosis and is localized to the bud neck; Spider biofilm induced CAALFM_C111790WA Ortholog(s) have thymidylate kinase activity, uridylate kinase activity, role in dTDP biosynthetic process, dTTP biosynthetic process, dUDP biosynthetic process and cytosol, nucleus localization CAALFM_C111800CA Ortholog(s) have AP-2 adaptor complex, cytosol, nucleus, prospore membrane localization CAALFM_C111810WA Putative transcription factor with Ku70/Ku80 beta-barrel DNA-binding motif; involved in telomerase regulation and telomere protection; mutation causes marginal increase in caspofungin sensitivity CAALFM_C111850WA Protein of unknown function; Hap43-repressed gene; mRNA binds to She3; repressed in hyphae; Efg1 and Efh1 regulated; 5'-UTR intron; induced by Mnl1 under weak acid stress; rat catheter biofilm induced CAALFM_C111860WA Predicted essential RNA-binding G protein; ortholog an effector of mating response pathway in S. cerevisiae; mainly associated with nuclear envelope and ER; flow model and Spider biofilm repressed CAALFM_C111870WA Putative high affinity methionine permease; alkaline upregulated by Rim101; Spider biofilm induced CAALFM_C111880WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C111890WA Protein of unknown function; Spider biofilm induced CAALFM_C111900CA Ortholog(s) have mRNA binding activity, role in DNA recombination, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, protein ubiquitination and cytoplasm, nucleolus, polysome localization CAALFM_C111910WA Putative nuclear pore-associated protein; Hap43p-induced gene; induced upon low-level peroxide stress; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C111920WA Ortholog(s) have ATPase activator activity, role in late endosome to vacuole transport via multivesicular body sorting pathway, positive regulation of protein oligomerization and endosome membrane, multivesicular body localization CAALFM_C111930WA Ortholog(s) have cellular bud neck, cellular bud tip, cytoplasm localization CAALFM_C111940CA Protein of unknown function; Hap43-induced gene CAALFM_C111950WA Protein of unknown function; rat catheter biofilm induced CAALFM_C111960CA Ortholog(s) have endoplasmic reticulum localization CAALFM_C111970CA Ortholog of C. dubliniensis CD36 : Cd36_11210, C. parapsilosis CDC317 : CPAR2_805180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116279 and Debaryomyces hansenii CBS767 : DEHA2B10714g CAALFM_C111980WA RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C111990WA Putative cell wall adhesin-like protein; repressed in core caspofungin response and by alpha pheromone in SpiderM medium; transcript reduced in ace2 mutant; flow model, rat catheter and Spider biofilm repressed CAALFM_C112000CA Planktonic growth-induced gene CAALFM_C112010CA S. cerevisiae Smy1 ortholog; Tn mutation affects filamentous growth; filament induced; has Mob2-dependent hyphal regulation; regulated by Nrg1, Tup1; oralpharyngeal candidasis induced; Spider biofilm induced; flow model biofilm repressed CAALFM_C112030WA Predicted enzyme of amino acid biosynthesis; Gcn4p-regulated; upregulated in biofilm; protein present in exponential and stationary growth phase yeast cultures; S. cerevisiae ortholog is Gcn4p regulated CAALFM_C112040WA Ortholog of C. dubliniensis CD36 : Cd36_11270 and Candida albicans WO-1 : CAWG_00238 CAALFM_C112050WA Putative 26S proteasome subunit; transcript regulated by Mig1; caspofungin repressed; regulated by Gcn2 and Gcn4; gene used for strain identification by multilocus sequence typing CAALFM_C112060CA Ortholog of C. dubliniensis CD36 : Cd36_11290, C. parapsilosis CDC317 : CPAR2_805090, Pichia stipitis Pignal : PICST_28850 and Candida guilliermondii ATCC 6260 : PGUG_02709 CAALFM_C112070CA Protein of unknown function; induced by nitric oxide CAALFM_C112080WA Putative sphingosine kinase; Tac1p-regulated expression; rat catheter biofilm induced CAALFM_C112090CA Protein of unknown function; Hap43-repressed gene; induced by alpha pheromone in SpiderM medium CAALFM_C112100CA Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC transporter; Gcn4p-regulated CAALFM_C112110CA Protein of unknown function; repressed by nitric oxide CAALFM_C112120WA Has domain(s) with predicted ATP binding, protein kinase activity, protein tyrosine kinase activity and role in protein phosphorylation CAALFM_C112130CA Predicted Zn(II)2Cys6 transcription factor; mutants are viable; repressed by fluphenazine; Spider biofilm induced CAALFM_C112140WA Has domain(s) with predicted cofactor binding activity CAALFM_C112150CA Ortholog(s) have role in macroautophagy and cytosol, nucleus, pre-autophagosomal structure localization CAALFM_C112160WA Putative secretory protein involved in S. cerevisiae sporulation; repressed during pseudohyphal growth in the presence of lysed macrophages; Hap43-repressed; Spider biofilm induced CAALFM_C112170CA Ortholog(s) have cytoplasm localization CAALFM_C112180CA Protein of unknown function; Hap43-repressed gene CAALFM_C112190WA Protein with a predicted BUL1 N-terminal and C-terminal domains; Bul1 binds the ubiquitin ligase Rsp5 in S. cerevisiae; Hap43-repressed gene; rat catheter biofilm induced CAALFM_C112200WA Protein of major facilitator superfamily; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Mcd4p, which acts in GPI anchor biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C112210WA Putative bifunctional enzyme with predicted indole-3-glycerol-phosphate synthase and anthranilate synthase activities; regulated by Gcn2p and Gcn4p CAALFM_C112220WA Putative ATP-binding protein with a predicted role in DNA replication; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle M/G1 phase CAALFM_C112230WA Ortholog of S. cerevisiae Snt1; an NAD-independent histone deacetylase; heterozygous transposon mutation affects filamentous growth; null mutants are viable CAALFM_C112240CA Predicted alanine-tRNA ligase; oxidative stress-induced via Cap1 CAALFM_C112250CA Ortholog(s) have cytosol, nucleus localization CAALFM_C112260WA Ortholog(s) have role in vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly and Vma12-Vma22 assembly complex, endoplasmic reticulum membrane localization CAALFM_C112270WA Ortholog(s) have dehydrodolichyl diphosphate synthase activity, role in dolichol biosynthetic process, protein glycosylation and dehydrodolichyl diphosphate synthase complex, lipid particle localization CAALFM_C112280CA Putative mitochondrial ribosomal protein of the large subunit; Hap43-induced; mutants are viable; protein level decreases in stationary phase CAALFM_C112290CA Rhomboid-like protein; similar to putative intramembrane serine proteases; role in filamentous growth; Gcn4-regulated; caspofungin repressed; Spider biofilm induced CAALFM_C112310CA Putative 66S pre-ribosomal particle component; Hap43-induced; essential for growth; transposon mutation affects filamentous growth; Spider biofilm induced CAALFM_C112320CA Subunit k of the mitochondrial F1F0 ATP synthase; a large enzyme complex required for ATP synthesis; Spider biofilm repressed CAALFM_C112330WA Protein of unknown function; flow model biofilm induced CAALFM_C112340CA Mitochondrial ribosomal protein S9; has N-terminal mitochondrial targeting signal and an S9 consensus motif; overexpression in S. cerevisiae causes respiratory defect that is reversible upon cessation of C. albicans gene expression CAALFM_C112350WA Ortholog(s) have 3'-5'-exoribonuclease activity, Ran GTPase binding, endoribonuclease activity, tRNA binding activity CAALFM_C112360CA 3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction CAALFM_C112370WA Chaperone component; involved in assembly of alpha subunits into the 20S proteasome; flow model biofilm induced CAALFM_C112380CA Putative tRNA-Trp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages CAALFM_C112390CA Ribosomal protein L27; Spider biofilm repressed CAALFM_C112400CA Ortholog of Candida albicans WO-1 : CAWG_00201 CAALFM_C112410CA Putative serine/threonine protein kinase; predicted role in sphingolipid-mediated signaling pathway that controls endocytosis; mRNA binds She3 and is localized to hyphal tips CAALFM_C112430WA Ortholog(s) have phosphatidylinositol-4,5-bisphosphate binding activity CAALFM_C112440WA Putative RNA exonuclease; induced in a ssr1 null mutant CAALFM_C112450CA GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form; Spider biofilm induced; flow model biofilm repressed CAALFM_C112470WA Protein of unknown function; induced by Mnl1 under weak acid stress CAALFM_C112480WA Ortholog of C. dubliniensis CD36 : Cd36_11670, C. parapsilosis CDC317 : CPAR2_201750, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115679 and Debaryomyces hansenii CBS767 : DEHA2E16940g CAALFM_C112490WA Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between late-Golgi and prevacuolar endosome-like compartments; rat catheter biofilm repressed CAALFM_C112510WA Plasma membrane protein involved in establishment of bud sites and linear direction of hyphal growth; filament induced, repressed by Rim101, Tup1; Hap43-induced; Spider biofilm induced CAALFM_C112520WA Putative subunit of the TRAPP complex; involved in targeting of ER-to-Golgi transport vesicles; flow model biofilm induced CAALFM_C112530CA Has domain(s) with predicted serine-type endopeptidase activity, role in retrograde vesicle-mediated transport, Golgi to ER and integral component of membrane localization CAALFM_C112540WA Ortholog of C. dubliniensis CD36 : Cd36_11720, C. parapsilosis CDC317 : CPAR2_201890, Candida tenuis NRRL Y-1498 : CANTEDRAFT_91948 and Debaryomyces hansenii CBS767 : DEHA2E16786g CAALFM_C112550CA Putative pre-replication complex helicase subunit; transcript regulated by Nrg1 and Mig1; periodic mRNA expression, peak at cell-cycle M/G1 phase; Hap43-induced CAALFM_C112560CA Functional homolog of S. cerevisiae Dmc1; a meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes CAALFM_C112570CA Putative elongator complex subunit; for modification of wobble nucleosides in tRNA; Spider biofilm induced CAALFM_C112580WA Ortholog(s) have fungal-type vacuole membrane localization CAALFM_C112590WA Putative mitochondrial ATP synthase; shows colony morphology-related gene regulation by Ssn6p; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced CAALFM_C112600CA Predicted DEAD-box ATP-dependent RNA helicase; functional homolog of S. cerevisiae Rok1; Hap43-induced; Spider biofilm induced CAALFM_C112610WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C112620WA Protein involved in cell polarity, Spitzenkorper formation; required for mouse virulence; localizes to hyphal tip; cell-cycle regulated localization in yeast-form cells; functional domains conserved with S. cerevisiae; Hap43p-induced gene CAALFM_C112630CA Protein involved in pre-mRNA splicing; Spider biofilm induced CAALFM_C112640WA Ortholog(s) have role in mitochondrial respiratory chain complex assembly, proteolysis and mitochondrial inner membrane peptidase complex localization CAALFM_C112650CA Ortholog(s) have ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity and role in free ubiquitin chain polymerization, postreplication repair, protein K63-linked ubiquitination CAALFM_C112660WA Ortholog(s) have role in activation of mitotic cell cycle spindle assembly checkpoint, mitotic DNA integrity checkpoint and mitotic spindle assembly checkpoint, more CAALFM_C112670CA Ortholog(s) have role in mRNA splicing, via spliceosome and U4/U6 snRNP, U4/U6 x U5 tri-snRNP complex localization CAALFM_C112680WA Ortholog(s) have unfolded protein binding activity, role in ribosome biogenesis and nucleolus localization CAALFM_C112690CA Ortholog of C. dubliniensis CD36 : Cd36_11870, C. parapsilosis CDC317 : CPAR2_201650, Candida tenuis NRRL Y-1498 : cten_CGOB_00224 and Debaryomyces hansenii CBS767 : DEHA2D04884g CAALFM_C112700WA Ortholog of Candida albicans WO-1 : CAWG_00172 CAALFM_C112710CA Ortholog of C. dubliniensis CD36 : Cd36_11880, Candida tenuis NRRL Y-1498 : cten_CGOB_00231, Debaryomyces hansenii CBS767 : DEHA2D04928g and Pichia stipitis Pignal : PICST_29234 CAALFM_C112720CA Ortholog of C. dubliniensis CD36 : Cd36_11890 and Candida albicans WO-1 : CAWG_00170 CAALFM_C112730WA Protein containing a BAR domain, which is found in proteins involved in membrane curvature; null mutant does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by mutants in related genes RVS161 and RVS167 CAALFM_C112740WA Predicted cysteine proteinase domain; mutants are viable CAALFM_C112750CA Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing; possible role in cell cycle progression; Spider biofilm induced CAALFM_C112760WA Putative nuclear export protein; Hap43p-induced gene; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 CAALFM_C112770WA Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C112780WA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C112790CA Putative fatty acid elongase; predicted role in sphingolipid biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method; Spider and flow model biofilm induced CAALFM_C112800WA Ortholog of C. dubliniensis CD36 : Cd36_11980, C. parapsilosis CDC317 : CPAR2_201330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114815 and Debaryomyces hansenii CBS767 : DEHA2G10032g CAALFM_C112810WA Ortholog(s) have 5-amino-6-(5-phosphoribosylamino)uracil reductase activity, role in riboflavin biosynthetic process and cytosol, nucleus localization CAALFM_C112820CA Ortholog(s) have RNA polymerase I activity, RNA polymerase II activity, RNA polymerase III activity, RNA-directed RNA polymerase activity CAALFM_C112830CA Ortholog(s) have ubiquitin binding activity and cytoplasm localization CAALFM_C112840WA Ortholog(s) have role in cellular response to DNA damage stimulus and FANCM-MHF complex localization CAALFM_C112850WA Protein of unknown function, serum-induced CAALFM_C112860CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C112870CA Ortholog of Candida albicans WO-1 : CAWG_00155 CAALFM_C112880CA Has domain(s) with predicted DNA binding, nucleic acid binding activity CAALFM_C112900WA Ortholog of C. dubliniensis CD36 : Cd36_12030 and Candida albicans WO-1 : CAWG_00152 CAALFM_C112910WA Protein of unknown function; Spider biofilm repressed CAALFM_C112920CA Ortholog(s) have Rab GTPase binding activity and Golgi apparatus, endoplasmic reticulum localization CAALFM_C112930CA Predicted membrane transporter; sugar porter (SP) family member, major facilitator superfamily; caspofungin induced; Spider biofilm induced CAALFM_C112940CA Ortholog of C. parapsilosis CDC317 : CPAR2_801655, Candida tropicalis MYA-3404 : CTRG_06172 and Candida albicans WO-1 : CAWG_02233 CAALFM_C112950WA Protein of unknown function; repressed in ssr1 mutant; Spider biofilm induced CAALFM_C112960CA Formin; role in cytoskeletal organization, cell polarity; role in systemic virulence in mouse; cell-cycle regulated localization to site of polarized growth, bud neck; localizes to Spitzenkorper of hyphae, minor localization at septum CAALFM_C112970CA Guanyl-nucleotide exchange factor for the small G-protein Sec4; delivery of post-Golgi secretory vesicles to sites of polarized growth; phosphorylation by Cdc28 needed for normal hyphal growth; Hap43-repressed; flow model biofilm induced CAALFM_C113010WA Ortholog(s) have mRNA binding, translation regulator activity and role in mitochondrial respiratory chain complex IV biogenesis, positive regulation of mitochondrial translational initiation CAALFM_C113020CA Essential protein; similar to S. cerevisiae Spc3p, a component of the signal peptidase complex required for signal peptidase activity; predicted integral ER membrane protein; complements spc3 and suppresses sec61 S. cerevisiae mutants CAALFM_C113030CA Putative tRNA-Cys synthetase; induced by alpha pheromone in SpiderM medium; ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C113050WA Ribosomal protein L14; promoter bound directly by Tbf1p; Hap43p-induced gene CAALFM_C113060CA Ortholog(s) have role in mitochondrial translation and mitochondrion localization CAALFM_C113070CA Omega-3 fatty acid desaturase; production of alpha-linolenic acid, a major component of membranes; caspofungin induced; Plc1-regulated; colony morphology-related gene regulation by Ssn6; Spider biofilm induced, flow model biofilm repressed CAALFM_C113080WA Ala- Leu- and Ser-rich protein; secreted; N-terminal hydrophobic region; possible glycosylation; opaque-specific transcript; repressed by alpha pheromone in opaque MTLa homozygotes; fluconazole-induced; Spider biofilm induced CAALFM_C113100WA Putative adhesin-like protein; Spider biofilm induced CAALFM_C113110CA Major chitin synthase of yeast and hyphae; synthesizes short-chitin fibrils; Chs4-activated; transcript induced at yeast-hyphal transition; Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289; Spider biofilm induced CAALFM_C113120CA Peripheral membrane protein; role in endocytosis and vacuole integrity; flow model and rat catheter biofilm repressed CAALFM_C113130CA Putative histidine permease; fungal-specific (no human or murine homolog); Hap43p-induced gene CAALFM_C113140CA bHLH transcription factor; control of glycolysis; required for biofilm formation; hyphally regulated by Cph1, Cyr1; flucytosine, Hog1 induced; amphotericin B, caspofungin repressed; induced in flow model biofilm and planktonic cultures CAALFM_C113160WA Mannose-1-phosphate guanyltransferase; Hap43, macrophage-repressed; stationary phase enriched protein; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C113170CA Protein similar to S. cerevisiae Msh6p, which is involved in mismatch repair; repressed under Cdc5p depletion; Hap43p-induced gene CAALFM_C113180WA Ortholog of C. dubliniensis CD36 : Cd36_12240, C. parapsilosis CDC317 : CPAR2_801750, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135403 and Pichia stipitis Pignal : PICST_29111 CAALFM_C113190WA Mitochondrial membrane protein of unknown function; Spider biofilm induced CAALFM_C113200CA Ortholog(s) have 3'-5'-exoribonuclease activity and role in U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) CAALFM_C113220CA Ankyrin-repeat protein; induced by fluphenazine CAALFM_C113240WA Protein of unknown function; Spider biofilm induced CAALFM_C113250WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C113260WA Ortholog(s) have FK506 binding activity and cytoplasm, nucleus localization CAALFM_C113270WA Putative ATPase; predicted role in ER-associated protein catabolism; induced during chlamydospore formation in both C. albicans and C. dubliniensis; rat catheter biofilm repressed CAALFM_C113280CA Ortholog(s) have endoplasmic reticulum, integral component of membrane localization CAALFM_C113290WA Ortholog(s) have role in ascospore wall assembly and ascospore wall, endoplasmic reticulum, mitochondrion, prospore membrane localization CAALFM_C113300CA Putative 19S regulatory particle of the 26S proteasome; regulated by Gcn2p and Gcn4p CAALFM_C113310WA Non-essential protein involved in cell morphogenesis CAALFM_C113320CA Protein of unknown function; Spider biofilm repressed CAALFM_C113330CA Ortholog(s) have spermine synthase activity, role in pantothenate biosynthetic process, spermine biosynthetic process and cytoplasm localization CAALFM_C113350WA Amino-acid-regulated transcription factor; activates transcription of amino acid permease genes; activated by amino-acid-induced proteolytic processing (Ssy1, Csh3 dependent); required for alkalinization of medium; Spider biofilm induced CAALFM_C113360CA Ortholog of Rmp1; subunit of RNase MRP subunit that processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; rat catheter and Spider biofilm induced CAALFM_C113370WA Ortholog(s) have role in ER-associated ubiquitin-dependent protein catabolic process and cytoplasm, nucleus localization CAALFM_C113380WA Ortholog(s) have role in cellular bud site selection, mRNA export from nucleus, mRNA splicing, via spliceosome and RES complex localization CAALFM_C113390WA Protein of unknown function; rat catheter biofilm induced CAALFM_C113400CA Putative mitochondrial carrier protein; transcript is alkaline upregulated rat catheter biofilm induced CAALFM_C113410WA Putative cytochrome c oxidase assembly protein; Plc1-regulated; rat catheter biofilm induced CAALFM_C113420CA 5'->3' exoribonuclease of cytoplasmic stress granules; role in filamentous growth; complements slow growth/mating of S. cerevisiae kem1 mutant; required for SD or Spider medium biofilm formation CAALFM_C113430CA Protein of unknown function; Spider biofilm induced CAALFM_C113440CA Putative transcription factor with zinc finger DNA-binding motif, involved in regulation of white-opaque switching and filamentous growth CAALFM_C113450WA GPI-anchored hyphal cell wall protein; macrophage-induced; repressed by neutrophils; resistance to killing by neutrophils, azoles; regulated by Rfg1, Efg1, Nrg1, Tup1, Cyr1, Bcr1, Hap43; Spider and flow model biofilm induced CAALFM_C113470WA Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway, phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; Spider and flow model biofilm induced CAALFM_C113480WA Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; surface localized in yeast and hyphae; antigenic in host; farnesol-downregulated in biofilm; Spider biofilm induced CAALFM_C113490CA Ortholog(s) have endoplasmic reticulum localization CAALFM_C113510CA Has domain(s) with predicted role in lipid metabolic process CAALFM_C113520CA Mitochondrial protein involved in utilization of carbon sources, filamentous growth and virulence CAALFM_C113540WA Putative O-acyltransferase with a role in glycerol uptake; functionally complements growth of S. cerevisiae gup1 mutant under salt stress; required for normal ergosterol distribution, hyphal growth, biofilm formation CAALFM_C113550CA Nuclear pore protein CAALFM_C113560WA S. cerevisiae ortholog Sae2 is an endonuclease that processes hairpin DNA structures with the MRX complex, involved in meiotic and mitotic double-strand break repair; upregulated in a cyr1 null mutant CAALFM_C113570WA Putative RNA-binding protein; Hap43p-repressed gene; protein induced during the mating process CAALFM_C113580WA Functional homolog of S. cerevisiae Sec18p, which acts in protein transport; conserved ATP binding site; not glycosylated CAALFM_C113590WA Ortholog of C. dubliniensis CD36 : Cd36_12580 CAALFM_C113600WA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C113610CA Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p; interacts with Snf4p; interaction with Snf1p complex is regulated by carbon source, decreased on ethanol; N-terminal myristoylation; Hog1p-downregulated CAALFM_C113620WA Zn(II)2Cys6 transcription factor; required for Spider model biofilm formation; mutant displays abnormal colony morphology and invasive growth; caspofungin repressed; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C113630WA Putative cytochrome b2 precursor; induced in high iron; alkaline repressed; colony morphology-related gene regulation by Ssn6; Hap43-repressed; pider biofilm induced CAALFM_C113640WA Putative copper-binding transcription factor; required for normal resistance to copper; activates transcription of metallothionein genes; Hap43-repressed; Spider biofilm induced CAALFM_C113650CA Ortholog(s) have GTPase regulator activity and cytoplasm, nuclear envelope localization CAALFM_C113660WA Putative DNA-dependent ATPase involved in DNA repair; induced under hydroxyurea treatment; plays an essential role during mitotic growth; mutants display aberrant cell and nuclear morphology CAALFM_C113670WA Putative mitochondrial fumarate reductase; regulated by Ssn6p, Gcn2p, and Gcn4p; Hog1p-downregulated; stationary phase enriched protein; Hap43p-repressed gene CAALFM_C113680CA Glycine decarboxylase, subunit H; protein level decrease in stationary phase cultures CAALFM_C113690CA Ortholog(s) have SNAP receptor activity and role in Golgi to plasma membrane transport, endocytosis, exocytosis, vesicle fusion CAALFM_C113700WA Actin; gene has intron; transcript regulated by growth phase, starvation; at polarized growth site in budding and hyphal cells; required for wild-type Cdc42 localization; unprocessed N terminus; Hap43-induced; Spider biofilm repressed CAALFM_C113710CA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C113720WA Ortholog(s) have cytoplasm localization CAALFM_C113730CA Putative 18S rRNA dimethylase; predicted role in rRNA modification and processing; Hap43-induced; likely to be essential for growth based on insertional mutagenesis strategy; F-12/CO2 early biofilm induced CAALFM_C113740WA Ortholog of S. cerevisiae Kar9; role in mitotic spindle positioning; nonessential; localizes to bud tip, bud neck, hyphal tip; wild-type localization requires actin and microtubule cytoskeleton; induced by alpha factor CAALFM_C113750CA Ortholog of C. dubliniensis CD36 : Cd36_12740, C. parapsilosis CDC317 : CPAR2_201620, Candida tenuis NRRL Y-1498 : CANTEDRAFT_107586 and Debaryomyces hansenii CBS767 : DEHA2D04994g CAALFM_C113760WA Phosphoacetylglucosamine mutase (N-acetylglucosamine-phosphate mutase); enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis CAALFM_C113770CA Ortholog(s) have mitochondrion localization CAALFM_C113780WA Class V myosin; nonessential; sole class V myosin in C. albicans; required for WT actin cytoskeletal polarity, nuclear organization, migration, hyphal growth; conserved myosin ATPase/tail domains; Hap43-induced; flow model biofilm repressed CAALFM_C113790CA Ortholog(s) have cytosol, nucleus localization CAALFM_C113800CA Putative urea transporter; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C113810WA Ortholog of C. dubliniensis CD36 : Cd36_12800, C. parapsilosis CDC317 : CPAR2_203460, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94106 and Debaryomyces hansenii CBS767 : DEHA2C13948g CAALFM_C113820CA Protein of unknown function; Hap43-induced; Spider biofilm induced CAALFM_C113830CA Pyruvate dehydrogenase complex protein X; essential component of the mitochondrial pyruvate dehydrogenase complex; role in the respiratory pathway; protein present in exponential and stationary growth phase yeast; Spider biofilm repressed CAALFM_C113840WA Ortholog(s) have inorganic cation transmembrane transporter activity and role in cellular cobalt ion homeostasis, cellular manganese ion homeostasis, cobalt ion transport, manganese ion transport CAALFM_C113850CA Putative allantoate permease; mutant is viable CAALFM_C113860CA 6-phosphogluconate dehydrogenase; soluble in hyphae; farnesol, macrophage-induced protein; antigenic in mice; dual localization to cytosol and peroxisomes depends on alternative splicing; rat catheter and Spider biofilm repressed CAALFM_C113870WA ATP sulfurlyase; sulfate assimilation; repressed by Met, Cys, Sfu1, or in fluconazole-resistant isolate; Hog1, caspofungin, white phase-induced; induced on biofilm formation, even in presence of Met and Cys; Spider, F-12/CO2 biofilm induced CAALFM_C113880CA C2H2 transcription factor; Spider biofilm induced CAALFM_C113900CA Putative serine palmitoyltransferase component; mutation confers hypersensitivity to aureobasidin A CAALFM_C113910CA Ortholog(s) have mitochondrion localization CAALFM_C113920WA Protein of unknown function; induced during planktonic growth CAALFM_C113930WA Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast; peroxisomal targeting sequence (PTS1); Spider biofilm induced CAALFM_C113940WA Adhesin-like protein; involved in cell wall maintenance, redundant with Sun41; possibly secreted; macrophage-repressed; repressed by Rim101, Cyr1, Ras1; Spider biofilm induced CAALFM_C113950CA Ortholog(s) have Atg8 ligase activity, enzyme activator activity, protein tag activity and role in C-terminal protein lipidation, CVT pathway, autophagosome assembly, late nucleophagy, mitophagy, piecemeal microautophagy of nucleus CAALFM_C113960WA Protein involved in response to oxidative stress, binds and stabilizes Cap1p transcription factor in response to H2O2; essential for macrophage killing CAALFM_C113970CA Ortholog(s) have DNA binding, nucleosome binding activity CAALFM_C113980CA Putative urea transporter; fungal-specific (no human or murine homolog) CAALFM_C113990WA Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca6p; mutant shows virulence defect CAALFM_C114000CA Ortholog of S. cerevisiae Doa4;, a ubiquitin hydrolase involved in recycling ubiquitin from proteasome-bound ubiquitinated intermediates; oxidative stress-induced via Cap1; mutants are viable CAALFM_C114010WA Putative mitogen-activated protein (MAP) kinase with an unknown role; null mutant produces wrinkled colonies; similar to S. cerevisiae Smk1p, which is a protein kinase required for sporulation CAALFM_C114020WA Putative Rho GDP dissociation inhibitor; induced by nitric oxide independent of Yhb1p CAALFM_C114030WA Protein of unknown function; Spider biofilm induced CAALFM_C114040WA Phosphorylated protein; homozygous transposon insertion causes decreased colony wrinkling in filamentous growth-inducing conditions, but does not block hyphal formation in liquid media; Hap43-repressed CAALFM_C114050CA Putative ATP-dependent RNA helicase; fungal-specific (no human or murine homolog) CAALFM_C114060WA Glucan 1,3-beta-glucosidase; regulated by Nrg1, Tup1 and possibly Tac1; induced by NO and during cell wall regeneration; stationary phase enriched; possibly essential (UAU1 method); F-12/CO2 early biofilm induced; flow biofilm repressed CAALFM_C114080WA Nucleolar protein; component of the small subunit processome containing the U3 snoRNA; involved in pre-18S rRNA processing; flow model biofilm repressed CAALFM_C114090WA Ortholog(s) have chaperone binding, unfolded protein binding activity, role in chaperone-mediated protein complex assembly, protein import into mitochondrial intermembrane space, protein refolding and mitochondrial matrix localization CAALFM_C114100WA Rab-family GTPase involved in vacuolar trafficking, colocolizes with Vps1p and Ypt53p in late endosome CAALFM_C114110CA Ribosomal protein 4B; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C114120CA Pry family cell wall protein; Rim101, Efg1, Ssn6, alkaline repressed; O-glycosylation; no GPI anchor predicted; ketoconazol induced; regulated by Sef1, Sfu1, Hap4; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C114130WA High-affinity iron permease; required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p, Sef1p, Sfu1p, and Hap43p regulated; complements S. cerevisiae ftr1 iron transport; Hap43p-repressed CAALFM_C114140CA NAD-dependent histone deacetylase; mutations affect filamentous growth; genetic evidence suggests Set3/Hos2 function as a complex to regulate white-opaque switching, morphogenesis, and virulence; flow model biofilm induced CAALFM_C114150CA Putative maltase; regulated by Gcn4; repressed by amino acid starvation (3-AT); rat catheter biofilm induced CAALFM_C114160WA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine monomethylation and cytosol, nucleus localization CAALFM_C114170WA Ortholog(s) have ubiquitin-protein transferase activity and role in histone catabolic process, histone ubiquitination CAALFM_C114180WA Ortholog of C. dubliniensis CD36 : Cd36_13150, C. parapsilosis CDC317 : CPAR2_700610, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135418 and Debaryomyces hansenii CBS767 : DEHA2B01298g CAALFM_C114190CA Protein phosphatase inhibitor; Hap43-repressed; homozygous Tn insertion decreases colony wrinkling but does not block hyphal growth in liquid media; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced CAALFM_C114200WA Possible Golgi membrane protein; transcript positively regulated by Tbf1; mRNA binds She3 CAALFM_C114210CA Protein of unknown function; early-stage flow model biofilm induced; Hap43-repressed; Spider biofilm repressed CAALFM_C114220CA High-affinity iron permease; probably interacts with ferrous oxidase; regulated by iron level, ciclopirox olamine, amphotericin B, caspofungin; complements S. cerevisiae ftr1 iron transport defect; Hap43-repressed; Spider biofilm induced CAALFM_C114230CA Putative cohesin complex subunit; cell-cycle regulated periodic mRNA expression CAALFM_C114240WA Putative RSC chromatin remodeling complex component; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C114250CA Putative protein of unknown function; mutation confers hypersensitivity to amphotericin B CAALFM_C114260CA Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C114270WA Ortholog(s) have arylformamidase activity and role in NAD biosynthetic process CAALFM_C114280CA Putative RNA-binding protein; required for normal flow model biofilm growth; nuclear export is facilitated by Hmt1p; transcript upregulated in RHE model of oralcandidiasis; Spider biofilm repressed CAALFM_C114290CA Ortholog(s) have role in pheromone-dependent signal transduction involved in conjugation with cellular fusion and cytoplasm, membrane raft, nucleus, plasma membrane localization CAALFM_C114300CA Putative vacuolar membrane protein; predicted role in sphingolipid metabolism; transcript regulated by Nrg1 and Mig1; induced by prostaglandins CAALFM_C114310WA Deoxycytidine monophosphate (dCMP) deaminase; role in dUMP and dTMP biosynthesis; Spider biofilm repressed CAALFM_C114320CA Putative fumarylacetoacetate hydrolase; induced by nitric oxide independent of Yhb1; regulated by Sef1, Sfu1, Hap43; flow model biofilm induced CAALFM_C114330WA Ortholog(s) have tRNA-5-taurinomethyluridine 2-sulfurtransferase activity, role in mitochondrial tRNA wobble position uridine thiolation and mitochondrion localization CAALFM_C114340CA Transcription factor; alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mice; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation; Spider biofilm induced CAALFM_C114350WA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C114360CA Putative cell wall integrity and stress response subunit 4 precursor; transcription is specific to white cell type CAALFM_C114380CA Ortholog(s) have role in mRNA metabolic process, mitochondrial translational initiation and extrinsic component of membrane, mitochondrial inner membrane localization CAALFM_C114390WA Putative RNA polymerase subunit ABC10-alpha of RNA polymerase complexes I, II, and III; flucytosine induced; Spider biofilm induced CAALFM_C114400CA Ortholog(s) have role in meiotic mismatch repair, reciprocal meiotic recombination and MutLgamma complex, nucleus localization CAALFM_C114410WA Ortholog of S. cerevisisae/S. pombe Lsm5; Lsm (Like Sm) protein involved in mRNA decay; Predicted ORF from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis; flucytosine induced CAALFM_C114420WA Putative DNA damage inducible v-SNARE binding protein; macrophage/pseudohyphal-repressed CAALFM_C114430CA Protein with a predicted NADP-dependent oxidoreductase or aldo-keto reductase domain; Hap43-repressed; Spider biofilm repressed CAALFM_C114440CA Putative Rab GDP-dissociation inhibitor; GlcNAc-induced protein; Spider biofilm repressed CAALFM_C114450CA Putative X-Pro aminopeptidase; Spider biofilm repressed CAALFM_C114460WA Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; role in fission of mitochondria and peroxisome; Spider biofilm repressed CAALFM_C114470WA Putative zinc-finger domain protein with a predicted role in pre-mRNA splicing; Hap43-repressed; Spider biofilm repressed CAALFM_C114480WA Ortholog of Candida albicans WO-1 : CAWG_00007 CAALFM_C114490CA Predicted component of the sorting and assembly machinery (SAM complex) of the mitochondrial outer membrane, involved in protein import into mitochondria CAALFM_C114500CA Putative polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and aralkylamines (e.g. tryptamine, phenylethylamine); Spider biofilm repressed CAALFM_C114520WA Protein of unknown function; Spider biofilm repressed CAALFM_C114530WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C114550CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C114560CA Predicted ORF in retrotransposon Zorro2 with similarity to retroviral reverse transcriptase proteins CAALFM_C114570CA Protein encoded in retrotransposon Zorro2 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C114580CA Predicted ORF in retrotransposon Zorro2 with similarity to zinc finger-containing retroviral nucleocapsid proteins; un-merged from orf19.7275 in a revision of Assembly 21 based on comparative genome analysis and new sequence data CAALFM_C114590CA Member of a family of telomere-proximal genes of unknown function; transcript induced in an RHE model of oral candidiasis; Hap43-repressed CAALFM_C114630CA Similar to a region of the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; rat catheter biofilm repressed CAALFM_C200010WA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo CAALFM_C200030WA Protein with a predicted role in recruitment of RNA polymerase I to rDNA; caspofungin induced; flucytosine repressed; repressed in core stress response; repressed by prostaglandins CAALFM_C200050CA Ortholog of C. dubliniensis CD36 : Cd36_15040 CAALFM_C200060CA Protein of unknown function; Spider biofilm repressed CAALFM_C200070CA Putative SSU processome and 90S preribosome component; repressed in core stress response; repressed by prostaglandins CAALFM_C200080CA Putative alpha-1,6-mannanase; induced by mating factor in MTLa/MTLa opaque cells CAALFM_C200090WA Protein of unknown function; flow model biofilm induced CAALFM_C200100CA GPI-anchored cell surface protein of unknown function; Hap43p-repressed gene; fluconazole-induced; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C200110WA Predicted NADH-dependent flavin oxidoreductase; Hap43-repressed gene CAALFM_C200120CA Ortholog of S. cerevisiae Nnf2; possible role in chromosome segregation; mutants are viable, induced during the mating process CAALFM_C200140WA Ortholog of Ndt80; meiosis-specific transcription factor; activator of CDR1 induction by antifungal drugs; required for wild-type drug resistance and for Spider biofilm formation; transcript induced by antifungal drug treatment CAALFM_C200150WA Putative mitochondrial carrier protein; Hap43-repressed; rat catheter biofilm induced CAALFM_C200160CA Putative N-terminal acetyltransferase; Hap43p-repressed gene; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_C200170CA Putative molybdopterin-converting factor; fungal-specific (no human or murine homolog) CAALFM_C200180CA Predicted uricase; ortholog of S. pombe SPCC1223.09; Spider biofilm induced CAALFM_C200190CA Putative integral peroxisomal membrane protein; Hap43p-repressed gene CAALFM_C200200WA snRNP U5 splicing factor component; involved in positioning the 3' splice site during the 2nd catalytic step of splicing; Spider biofilm induced CAALFM_C200210WA 60S ribosomal ribosomal protein subunit; genes encoding cytoplasmic ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C200220CA Ortholog(s) have transcription factor activity, core RNA polymerase II binding activity and role in transcription elongation from RNA polymerase II promoter, transcriptional start site selection at RNA polymerase II promoter CAALFM_C200230WA Ortholog(s) have arginyltransferase activity, role in protein arginylation and cytoplasm localization CAALFM_C200240CA Copper-containing superoxide dismutase; gene family includes SOD1, SOD4, SOD5, and SOD6; gene may contain an intron; Hap43-repressed; flow model and rat catheter biofilm induced CAALFM_C200250WA Protein involved in ATP biosynthesis; repressed in hyphae; repressed by Efg1, Hap43; transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; rat catheter, flow model and Spider biofilm induced CAALFM_C200260CA Putative choline phosphate cytidylyltransferase/phosphoethanolamine cytidylyltransferase; repressed in hyphae compared vs yeast; Hap43-repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C200270CA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C200280CA Putative pre-mRNA-splicing factor; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C200290WA Ortholog(s) have chaperone binding activity, role in aerobic respiration, iron-sulfur cluster assembly and mitochondrion localization CAALFM_C200300CA Regulatory subunit of protein kinase CK2 (casein kinase II), beta subunit; null mutants are hypersensitive to caspofungin and hydrogen peroxide medium CAALFM_C200310WA Ortholog of Candida albicans WO-1 : CAWG_03811 CAALFM_C200320WA Ortholog(s) have protein anchor activity, role in protein insertion into ER membrane, retrograde vesicle-mediated transport, Golgi to ER and GET complex, mitochondrion localization CAALFM_C200330CA Component of the HIR complex, a nucleosome assembly factor involved in chromatin formation; involved in regulation of white-opaque switching frequency CAALFM_C200340CA Aromatic transaminase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101 independent alkaline induction; protein abundance affected by URA3 expression in CAI-4 strain; Gcn4-regulated; stationary phase enriched CAALFM_C200350WA Predicted DNA-dependent ATPase/helicase; Spider biofilm induced CAALFM_C200360CA Ortholog(s) have role in negative regulation of transcription from RNA polymerase II promoter in response to iron and cytosol, nucleus localization CAALFM_C200370WA Putative pleiotropic drug resistance regulatory protein 6; transcript regulated by Nrg1; induced by alpha pheromone in SpiderM medium CAALFM_C200380CA Putative DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density CAALFM_C200390CA Putative peroxisomal cystathionine beta-lyase; Gcn4p-regulated CAALFM_C200400CA Putative NADH dehydrogenase; repressed by nitric oxide, Hap43p-repressed CAALFM_C200410CA Ortholog of S. cerevisiae Ecm16, an essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP required for 18S rRNA synthesis; Hap43-induced; Spider biofilm induced CAALFM_C200420WA Ortholog of Nyv1, v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion in S. cerevisiae; Hap43-repressed gene CAALFM_C200430CA Putative DNA polymerase epsilon subunit D; null mutant is viable but slow-growing and displays abnormal invasive growth on SD and YPD media; Spider biofilm repressed CAALFM_C200440WA Predicted histone acetyltransferase involved in histone H4 acetylation; member of MYST family CAALFM_C200450CA Protein involved in regulation of mitosis; similar to S. cerevisiae Cdh1, which is an APC/C component; transcriptionally induced by Mnl1 under weak acid stress CAALFM_C200460WA Aspartic-type endopeptidase; involved in degradation of alpha pheromone; functional equivalent of S. cerevisiae Bar1; a-cell specific; induced by alpha pheromone CAALFM_C200470WA Putative nuclear pore membrane glycoprotein CAALFM_C200480CA Putative 4a-hydroxytetrahydrobiopterin dehydratase; transposon mutation affects filamentous growth; flow model biofilm induced; Spider biofilm induced CAALFM_C200490WA Ortholog(s) have role in Golgi to vacuole transport and AP-1 adaptor complex localization CAALFM_C200500WA Putative Zn(II)2Cys6 transcription factor; hypersensitive to toxic ergosterol analog ECC69 and/or ECC1384 CAALFM_C200510WA Protein of unknown function; S. pombe ortholog SPAC7D4.05 encodes a predicted hydrolase; Hap43-repressed; Spider biofilm induced CAALFM_C200520WA N-linked mannoprotein of cell wall and membrane; possible signal transducer; role in hyphal growth and HWP1 induction in alkaline pH; GPI modification predicted; dfg5 dcw1 double mutant is inviable; caspofungin-induced, fungal-specific CAALFM_C200540WA Protein with a multidrug and toxin extrusion protein domain; induced by Mnl1 under weak acid stress CAALFM_C200550WA Ortholog(s) have (R)-carnitine transmembrane transporter activity, choline transmembrane transporter activity, ethanolamine transmembrane transporter activity CAALFM_C200560WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C200570WA Ortholog(s) have DNA translocase activity, role in chromatin remodeling, nucleosome disassembly, transcription elongation from RNA polymerase II promoter and RSC complex localization CAALFM_C200580CA Putative vacuolar iron transporter; alkaline upregulated; caspofungin repressed; induced by Mnl1 under weak acid stress; Hap43-repressed CAALFM_C200590WA Ortholog of C. dubliniensis CD36 : Cd36_15550, C. parapsilosis CDC317 : CPAR2_213190, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119026 and Debaryomyces hansenii CBS767 : DEHA2G08514g CAALFM_C200600CA Protein with a predicted role in mitochondrial iron metabolism; Hap43-repressed; expression upregulated during growth in the mouse cecum; Spider biofilm induced CAALFM_C200610CA F1F0 ATP synthase complex subunit; gene has intron CAALFM_C200620CA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine trimethylation and cytoplasm localization CAALFM_C200630CA Ortholog(s) have role in allantoin catabolic process and cytosol, nucleus localization CAALFM_C200640WA Putative transcription factor with zinc finger DNA-binding motif CAALFM_C200650WA Ortholog of C. parapsilosis CDC317 : CPAR2_213140, C. dubliniensis CD36 : Cd36_15600, Lodderomyces elongisporus NRLL YB-4239 : LELG_01226 and Debaryomyces hansenii CBS767 : DEHA2B02442g CAALFM_C200660CA Cu-containing superoxide dismutase; role in response to host innate immune ROS; regulated on white-opaque switch; ciclopirox olamine induced; caspofungin repressed; SOD1,4,5,6 gene family; yeast-associated; Spider biofilm induced CAALFM_C200680CA Cu-containing superoxide dismutase; protects against oxidative stress; induced by neutrophils, hyphal growth, caspofungin, osmotic/oxidative stress; oralpharyngeal candidiasis induced; rat catheter and Spider biofilm induced CAALFM_C200690WA Protein with homology to magnesium-dependent endonucleases and phosphatases; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced CAALFM_C200700WA Ortholog(s) have ATP binding, ATPase activity, metallopeptidase activity, role in protein complex assembly, signal peptide processing and m-AAA complex, mitochondrial inner boundary membrane localization CAALFM_C200710WA Putative nuclear protein localization factor; Hap43-induced; Spider biofilm repressed CAALFM_C200720CA Putative transcription factor with zinc finger DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; caspofungin induced; mutation causes marginal increase in caspofungin sensitivity CAALFM_C200730CA Ortholog of C. dubliniensis CD36 : Cd36_15670, C. parapsilosis CDC317 : CPAR2_213100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135034 and Debaryomyces hansenii CBS767 : DEHA2E14960g CAALFM_C200740CA Ortholog(s) have sterol esterase activity, role in cellular lipid metabolic process, sterol metabolic process and fungal-type vacuole, integral component of membrane, lipid particle localization CAALFM_C200750WA Plasma membrane-associated protein; heterozygous null mutant displays sensitivity to virgineone; Spider biofilm induced CAALFM_C200760CA Proten of unknown function; transcript positively regulated by Sfu1; Hap43 repressed; Spider biofilm induced CAALFM_C200770WA Putative protein of unknown function; Hap43p-repressed gene; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B CAALFM_C200780WA Putative peroxisomal 3-ketoacyl CoA thiolase; Hap43-repressed CAALFM_C200790CA Ortholog(s) have diacylglycerol kinase activity, role in phosphatidic acid biosynthetic process and integral component of endoplasmic reticulum membrane localization CAALFM_C200800CA Putative GPI-anchored protein CAALFM_C200810CA Ortholog of C. dubliniensis CD36 : Cd36_15750, C. parapsilosis CDC317 : CPAR2_213000, Debaryomyces hansenii CBS767 : DEHA2D18524g and Pichia stipitis Pignal : PICST_42355 CAALFM_C200820WA Ortholog(s) have role in mitochondrial tRNA wobble uridine modification and mitochondrial inner membrane localization CAALFM_C200830CA Ortholog(s) have DNA translocase activity, lysine-acetylated histone binding activity and role in ATP-dependent chromatin remodeling, nucleosome disassembly, transcription elongation from RNA polymerase II promoter CAALFM_C200840WA Ortholog(s) have oxidoreductase activity, acting on NAD(P)H activity, role in iron-sulfur cluster assembly, nitric oxide biosynthetic process, oxidation-reduction process and mitochondrion localization CAALFM_C200850WA Putative phenylalanine-tRNA ligase; protein level decreases in stationary phase cultures; Hap43p-repressed gene CAALFM_C200860CA Protein of unknown function; Spider biofilm induced CAALFM_C200870WA Ortholog of C. dubliniensis CD36 : Cd36_15810, C. parapsilosis CDC317 : CPAR2_212950, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116162 and Debaryomyces hansenii CBS767 : DEHA2D18392g CAALFM_C200880WA Predicted dihydrodiol dehydrogenase; ortholog of S. pombe SPAC513.06c; flow model and rat catheter biofilm repressed CAALFM_C200890WA Ortholog of C. parapsilosis CDC317 : CPAR2_212930, C. dubliniensis CD36 : Cd36_15830, Candida orthopsilosis Co 90-125 : CORT_0A12240 and Candida tropicalis MYA-3404 : CTRG_01155 CAALFM_C200900WA Ortholog of C. parapsilosis CDC317 : CPAR2_212925, C. dubliniensis CD36 : Cd36_15840, Candida orthopsilosis Co 90-125 : CORT_0A12230 and Candida tropicalis MYA-3404 : CTRG_01156 CAALFM_C200910WA Putative GPI-anchored protein; macrophage-induced gene; mutants are viable CAALFM_C200920WA Protein of unknown function; rat catheter biofilm induced CAALFM_C200930CA Protein similar to S. cerevisiae Vps24p, which is a member of the ESCRT III protein sorting complex; downregulated upon adherence to polystyrene CAALFM_C200940WA Plasma membrane-associated protein; induced in cyr1 or ras1 mutant; induced by hypoxia, ketoconazole and during growth in the mouse cecum; induced in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C200950CA Putative heteropentameric replication factor C subunit; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_C200960CA Putative methionine sulfoxide reductase; Plc1-regulated; induced by human neutrophils, flucytosine; macrophage regulated (gene induced, protein decreased); possibly adherence-induced; Spider biofilm induced CAALFM_C200970CA Ortholog of S. cerevisiae Ubp13; putative ubiquitin carboxyl-terminal hydrolase; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C201000WA Putative MFS glucose transporter; glucose, fluconazole, Snf3 induced, expressed at high glucose; 20 member C. albicans glucose transporter family; 12 TM regions predicted; flow model biofilm induced; Spider biofilm repressed CAALFM_C201010WA High-affinity glucose transporter of the major facilitator superfamily; 20 members in the C. albicans glucose transporter family; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium; flow model biofilm induced CAALFM_C201020WA Putative high-affinity MFS glucose transporter; 20 family members; induced in core stress response; fluconazole, oralpharyngeal candidasis induced; flow model biofilm induced; Spider biofilm induced CAALFM_C201030WA Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translation and mitochondrial large ribosomal subunit localization CAALFM_C201040WA PProtein of unknown function; gene has intron; similar to human BLOC1S2 CAALFM_C201050WA Ortholog of Candida tropicalis MYA-3404 : CTRG_04298 CAALFM_C201060CA Protein with a predicted DnaJ chaperone domain and a CSL-type zinc finger; Spider biofilm induced CAALFM_C201070WA Ortholog(s) have RNA polymerase I activity and role in regulation of cell size, transcription elongation from RNA polymerase I promoter, transcription of nuclear large rRNA transcript from RNA polymerase I promoter CAALFM_C201090CA Ortholog(s) have protein binding, bridging activity, role in ergosterol biosynthetic process and endoplasmic reticulum membrane localization CAALFM_C201110CA Protein kinase A regulatory subunit; required for nuclear localization of Tpk1; physically interacts with Tpk1; essential; apoptosis-regulated; bcy1 heterozygous or bcy1 tpk2 mutant has filamentous growth defect CAALFM_C201120WA Similar to Hsp70 family chaperones; role in translocation of proteins into the ER; induced in high iron; protein present in exponential and stationary growth phase yeast cultures; flow model and Spider biofilm repressed CAALFM_C201130WA Transcriptional regulator; not required for buccal epithelial cell adherence or virulence in mouse systemic infection; null mutant colonies exhibit slightly decreased filamentation ratio; required for yeast adherence to silicone substrate CAALFM_C201140CA Ortholog of C. dubliniensis CD36 : Cd36_16030, C. parapsilosis CDC317 : CPAR2_213800, Debaryomyces hansenii CBS767 : DEHA2A01320g and Pichia stipitis Pignal : PICST_29434 CAALFM_C201150WA Ortholog(s) have ubiquitin-protein transferase activity, role in protein import into peroxisome matrix, protein monoubiquitination and integral component of peroxisomal membrane, peroxisomal importomer complex localization CAALFM_C201160WA Ortholog(s) have S-methyl-5-thioribose-1-phosphate isomerase activity, role in L-methionine biosynthetic process from methylthioadenosine and cytosol, nucleus localization CAALFM_C201170CA Ortholog(s) have role in Golgi to vacuole transport, ascospore wall assembly, cellular sphingolipid homeostasis, retrograde transport, endosome to Golgi and GARP complex, mitochondrion localization CAALFM_C201180WA Putative copper metallochaperone; Hap43p-repressed gene; rat catheter biofilm induced; Spider biofilm induced CAALFM_C201190CA Ortholog(s) have fungal-type vacuole membrane localization CAALFM_C201200CA Putative protein phosphatase regulatory subunit; Hap43-repressed gene; macrophage/pseudohyphal-induced; possibly regulated upon hyphal formation; flow model biofilm induced CAALFM_C201210CA Putative choline/ethanolamine transporter; mutation confers hypersensitivity to toxic ergosterol analog; colony morphology-related gene regulation by Ssn6; clade-associated gene expression CAALFM_C201220WA Ortholog(s) have structural constituent of nuclear pore activity and role in nuclear pore organization, poly(A)+ mRNA export from nucleus, protein import into nucleus, ribosomal large subunit export from nucleus CAALFM_C201230WA Has domain(s) with predicted L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and oxidoreductase activity, more CAALFM_C201240CA Ortholog(s) have DNA helicase activity, role in establishment of sister chromatid cohesion, interstrand cross-link repair, mitotic sister chromatid cohesion and cytosol, nuclear chromatin, site of double-strand break localization CAALFM_C201250WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C201260WA Ortholog of C. dubliniensis CD36 : Cd36_16140, C. parapsilosis CDC317 : CPAR2_213870, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92202 and Debaryomyces hansenii CBS767 : DEHA2A01980g CAALFM_C201270WA Similar to catabolic ser/thr dehydratases; repressed by Rim101; induced in low iron; regulated on white-opaque switch; filament induced; Tn mutation affects filamentation; flow model biofilm induced; Spider biofilm repressed CAALFM_C201300CA Alpha-1,2-mannosyltransferase; required for normal cell wall mannan content CAALFM_C201310WA Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in retrograde transport, endosome to Golgi and endosome localization CAALFM_C201320WA Ortholog(s) have structural molecule activity, role in proteasome assembly, ubiquitin-dependent protein catabolic process and nucleus, proteasome regulatory particle, lid subcomplex, proteasome storage granule localization CAALFM_C201330CA Required for wild-type lifespan, asymmetric inheritance of oxidatively damaged proteins, rDNA silencing; regulates phenotypic switch in strain 3153A, not WO-1; partially complements S. cerevisiae sir2 mating defect; Spider biofilm induced CAALFM_C201340WA Ortholog(s) have cytoplasm localization CAALFM_C201350CA Putative sorting nexin; induced during the mating process CAALFM_C201360CA Protein with predicted GPI modification; dfg5 dcw1 double mutant is inviable; not required for wild-type hyphal growth; upregulated in cyr1 mutant (yeast or hyphal form); Hap43-induced CAALFM_C201370CA Ortholog of C. dubliniensis CD36 : Cd36_16230, C. parapsilosis CDC317 : CPAR2_213950, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112720 and Debaryomyces hansenii CBS767 : DEHA2A01848g CAALFM_C201380WA Phospholipase B; Hog1-induced; regulated by Ssn6; putative GPI-anchor; repressed during cell wall regeneration; clade-associated gene expression; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_C201390WA Ortholog(s) have phosphatidylinositol-4,5-bisphosphate binding activity, role in actin cortical patch assembly, actin filament organization, endocytosis and actin cortical patch, mating projection tip localization CAALFM_C201400CA Protein similar to S. cerevisiae Esc4; a protein that represses transposition; transposon mutation affects filamentation; rat catheter biofilm repressed CAALFM_C201410CA B-type mitotic cyclin (cyclin-dependent protein kinase regulatory subunit); essential; required for wild-type mitotic exit; role in cell polarization; interacts with catalytic subunit Cdk1; Spider biofilm repressed CAALFM_C201420CA Has domain(s) with predicted sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding activity and role in regulation of transcription, DNA-templated CAALFM_C201430WA Adenine phosphoribosyltransferase; flucytosine induced; repressed by nitric oxide; protein level decreased in stationary phase yeast cultures CAALFM_C201440CA Ortholog(s) have ATP-dependent microtubule motor activity, plus-end-directed activity CAALFM_C201450CA Protein of unknown function; induced in azole-resistant strain that overexpresses MDR1; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm induced CAALFM_C201460CA Ortholog of C. dubliniensis CD36 : Cd36_16320, Candida tropicalis MYA-3404 : CTRG_01238 and Candida albicans WO-1 : CAWG_03918 CAALFM_C201470WA Subunit of the RNA polymerase II mediator complex; transposon mutation affects filamentous growth; suppresses S. cerevisiae diploid filamentous (flo8, ste7, ste12, tec1) or haploid invasive (flo8) mutant growth defects CAALFM_C201480WA Protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growth CAALFM_C201490CA Putative RNA polymerase transcription factor TFIIH core component; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C201500WA Ortholog of Candida albicans WO-1 : CAWG_03922 CAALFM_C201510CA Ortholog(s) have tRNA-specific adenosine deaminase activity, role in tRNA modification and cytoplasm, nucleus localization CAALFM_C201520WA Protein similar to S. cerevisiae Ppe1p; shows genetic interaction with some genes involved in diploid filamentous growth and haploid invasive growth in S. cerevisiae CAALFM_C201530CA Putative glutamine-dependent NAD synthetase, involved in NAD salvage pathway CAALFM_C201540WA S. pombe ortholog SPCC576.01c is a predicted sulfonate dioxygenase; possibly transcriptionally regulated upon hyphal formation; Spider biofilm induced CAALFM_C201550WA Putative Mg2+-dependent phosphatidate phosphatase; transcript regulated by Nrg1 CAALFM_C201560WA Putative beta-mannosyltransferase involved in beta-1,2-mannosylation of phospholipomannan; 9-member family includes Bmt1, Bmt2, Bmt3, and Bmtp with roles in mannosylation of cell wall phosphopeptidomannan; Spider biofilm induced CAALFM_C201570WA Has domain(s) with predicted N-acetyltransferase activity CAALFM_C201580WA Putative 3'-5' RNA exonuclease with a predicted role in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs; rat catheter biofilm induced CAALFM_C201590WA Cytochrome c oxidase; flucytosine induced; repressed by nitric oxide CAALFM_C201600CA Ortholog(s) have protein phosphatase type 2A regulator activity, protein serine/threonine phosphatase activity CAALFM_C201610CA Ribosomal protein; regulated by Nrg1, Tup1; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5'-UTR; Spider biofilm repressed CAALFM_C201620WA Putative cytochrome c oxidase subunit IV; Mig1-regulated; macrophage/pseudohyphal-induced gene; macrophage-induced protein; repressed by nitric oxide; 5'-UTR intron; Hap43-repressed CAALFM_C201630WA 2-hydroxyacid dehydrogenase domain-containing protein; Hap43-repressed gene; induced by alpha pheromone in SpiderM medium CAALFM_C201640WA Protein required for assembly of the cortical actin cytoskeleton; contains three SH3 domains; transcription is regulated by Nrg1 and Mig1; flow model biofilm repressed CAALFM_C201650WA Ortholog(s) have mRNA (N6-adenosine)-methyltransferase activity, role in mRNA methylation, meiotic nuclear division, negative regulation of pseudohyphal growth and MIS complex localization CAALFM_C201660CA Protein of unknown function; possible ER protein; Hap43p-repressed; Spider biofilm induced CAALFM_C201670CA Putative oligosaccharyltransferase complex component; flow model and rat catheter biofilm repressed CAALFM_C201680CA Ortholog of the mitochondria localized S. cerevisiae Pib2 protein of unknown function; has a FYVE zinc finger domain; Spider biofilm induced CAALFM_C201690WA Putative succinate dehydrogenase; enzyme of citric acid cycle; repressed by nitric oxide; Efg1, Hap43 repressed CAALFM_C201700CA Predicted transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C201710WA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules; expression regulated during planktonic growth CAALFM_C201720CA Ortholog(s) have copper ion binding activity, role in mitochondrial respiratory chain complex IV assembly and extrinsic component of mitochondrial inner membrane, mitochondrial intermembrane space localization CAALFM_C201730WA Ortholog of S, cerevisiae Spc24; a component of the conserved kinetochore-associated Ndc80 complex involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; Hap43-induced gene CAALFM_C201740CA Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced CAALFM_C201750CA Protein with a life-span regulatory factor domain; regulated by Sef1, Sfu1, and Hap43; flow model biofilm induced; Spider biofilm induced CAALFM_C201760CA Ortholog of C. dubliniensis CD36 : Cd36_16630, C. parapsilosis CDC317 : CPAR2_210300, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116870 and Debaryomyces hansenii CBS767 : DEHA2B04334g CAALFM_C201780WA Mucin family adhesin-like protein; cell wall damage sensor; required for Cek1 phosphorylation by cell wall stress; Rim101-repressed; activation releases extracellular domain into medium; Spider biofilm induced CAALFM_C201800WA Predicted ORF in retrotransposon Tca16 with similarity to the Gag-Pol region of retrotransposons; added to Assembly 21 based on comparative genome analysis; overlaps orf19.1490.2, which is annotated as blocked reading frame CAALFM_C201820CA Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U1 snRNP, U2-type prespliceosome localization CAALFM_C201830WA Putative component of the U1 snRNP; involved in splicing; Hap43-induced gene; Spider biofilm induced CAALFM_C201840CA Protein similar to S. cerevisiae Rad7p, which is a subunit of the Nucleotide Excision Repair Factor 4; induced under hydroxyurea treatment CAALFM_C201850WA S. cerevisiae Rad23 ortholog; binds damaged DNA; Spider biofilm repressed CAALFM_C201860CA Ortholog(s) have role in L-methionine biosynthetic process from methylthioadenosine and cytosol, nucleus localization CAALFM_C201870CA Putative transcription factor with zinc finger DNA-binding motif; Hap43p-repressed gene CAALFM_C201880CA Putative transcription factor with zinc cluster DNA-binding motif; involved in virulence CAALFM_C201890WA Putative zinc-finger transcription factor, similar to A. nidulans FarA and FarB; activates genes required for fatty acid degradation; induced by oleate; null mutant displays carbon source utilization defects and slightly reduced virulence CAALFM_C201900CA Ortholog of C. dubliniensis CD36 : Cd36_16720, C. parapsilosis CDC317 : CPAR2_210210, Candida tenuis NRRL Y-1498 : CANTEDRAFT_128446 and Debaryomyces hansenii CBS767 : DEHA2B04092g CAALFM_C201910WA Has domain(s) with predicted aminoacyl-tRNA hydrolase activity CAALFM_C201920CA Putative patatin-like phospholipase; fungal-specific (no human or murine homolog) CAALFM_C201930CA Ortholog(s) have cytoplasm localization CAALFM_C201950CA Putative negative regulator of exit from mitosis; Plc1-regulated; rat catheter biofilm induced CAALFM_C201970CA Protein similar to S. cerevisiae Rod1;a membrane protein with a role in drug tolerance; repressed by Rgt1; mutant is viable CAALFM_C201980CA Sur7 family protein with PalI-like domains; not required for stress responses; mutant is viable CAALFM_C201990CA Phosphatidylinositol 3-phosphate 5-kinase; required for hyphal growth on solid media, and for wild-type vacuolar morphology and acidification; not required for wild-type virulence in mouse systemic infection or for adherence to HeLa cells CAALFM_C202000WA Ortholog(s) have enzyme binding, phosphatidylinositol-4-phosphate binding activity CAALFM_C202010CA Chitinase; similar to S. cerevisiae sporulation-specific Cts2p; functionally complements A. gossypii cts2 mutant sporulation defect; homozygous null mutation causes no obvious defects; transcription decreases upon yeast-to-hyphal switch CAALFM_C202020WA Ortholog(s) have ubiquitin-specific protease activity, role in negative regulation of gluconeogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein deubiquitination and nucleoplasm localization CAALFM_C202030WA 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid synthesis; GCN-regulated; feedback-inhibited by phe if expressed in S. cerevisiae; decreased in stationary phase; flow model biofilm repressed CAALFM_C202040WA Protein of unknown function; Hap43-repressed gene CAALFM_C202050CA Ortholog of C. dubliniensis CD36 : Cd36_16850, C. parapsilosis CDC317 : CPAR2_211990, Candida tenuis NRRL Y-1498 : cten_CGOB_00169 and Debaryomyces hansenii CBS767 : DEHA2G03036g CAALFM_C202060CA Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B CAALFM_C202070WA Septin; mutant has no obvious phenotype CAALFM_C202090WA Ortholog(s) have role in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and cytoplasm, nucleus localization CAALFM_C202100WA Protein involved in transcriptional regulation; ortholog of S. cerevisiae Snf2p, which is the catalytic subunit of the SWI/SNF chromatin remodeling complex; interacts with Swi1p; SWI/SNF complex is essential for hyphal growth and virulence CAALFM_C202110CA Protein of unknown function; Spider biofilm induced CAALFM_C202120WA Putative mitochondrial RNA polymerase specificity factor; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C202130CA Protein of unknown function; macrophage-induced gene CAALFM_C202140CA Protein of unknown function CAALFM_C202150CA Ortholog(s) have RNA binding, protein heterodimerization activity and role in mRNA polyadenylation, pre-mRNA cleavage required for polyadenylation, response to DNA damage checkpoint signaling CAALFM_C202160WA Protein of the mitochondrial outer membrane, component of the Sorting and Assembly Machinery (SAM) involved in insertion of proteins into the outer membrane; mutants show loss of mtDNA CAALFM_C202170WA Possible vacuolar protein; Hap43-induced gene CAALFM_C202180WA Ortholog of S. cerevisiae Zrt3, vacuolar membrane zinc transporter; predicted Kex2 substrate; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm induced CAALFM_C202190CA Protein of unknown function; Hap43-induced gene CAALFM_C202200WA Putative vacuolar transporter; Hap43-induced; required for normal filamentous growth; mRNA binds She3 and is localized to hyphal tips CAALFM_C202210CA Putative syntaxin-like t-SNARE; macrophage/pseudohyphal-repressed CAALFM_C202220CA Protein of unknown function; F-12/CO2 early biofilm induced CAALFM_C202230CA Protein with a globin-like domain; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C202240CA Protein similar to S. cerevisiae Hex3p, which is involved in DNA damage response; transposon mutation affects filamentous growth CAALFM_C202250CA Leucine zipper transcription factor; repressor of INO1 involved in inositol biosynthesis; functional homolog of S. cerevisiae Opi1; has putative Opi1-Sin3 interaction domain; interacts with ScSin3, but not CaSin3 CAALFM_C202260WA Putative cis-golgi localized protein involved in ER to Golgi transport; Spider biofilm repressed CAALFM_C202270CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C202280WA Membrane-localized protein of unknown function CAALFM_C202290CA Ortholog(s) have double-stranded DNA binding, polynucleotide 3'-phosphatase activity and role in double-strand break repair CAALFM_C202300WA Ortholog(s) have role in mRNA splicing, via spliceosome and U4/U6 x U5 tri-snRNP complex localization CAALFM_C202310WA Plasma membrane-associated protein identified in detergent-resistant membrane fraction (possible lipid raft component); repressed by nitric oxide; predicted transmembrane helix CAALFM_C202320CA Putative peptidyl-prolyl cis-trans isomerase; macrophage-induced protein; protein levels decrease in stationary phase yeast cultures; predicted mitochondrial localization; overlaps orf19.1551 CAALFM_C202330WA Predicted protein of unknown function; overlaps CPR3/orf19.1552 CAALFM_C202340CA Putative epsin; induced during the mating process; transcript is upregulated in an RHE model of oral candidiasis CAALFM_C202350CA Putative nuclear pore-associated protein, required for small ribosomal subunit biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C202360CA Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity and role in protein methylation CAALFM_C202370CA Aspartate-semialdehyde dehydrogenase; forms a homodimer; conserved in bacteria, archaea, and fungi but not in mammals; ketoconazole-repressed; protein present in exponential and stationary growth phase yeast cultures; GlcNAc-induced protein CAALFM_C202380WA Protein involved in chromatin assembly and disassembly; ortholog of S. cerevisiae Pob3; transposon mutation affects filamentous growth; rat catheter biofilm repressed CAALFM_C202390WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced; repressed by alpha pheromone in SpiderM medium CAALFM_C202400WA Ortholog(s) have endoplasmic reticulum localization CAALFM_C202410WA Plasma membrane-localized protein of unknown function CAALFM_C202420CA Protein of unknown function CAALFM_C202430WA Putative U3 snoRNP protein; Hap43-induce; physically interacts with TAP-tagged Nop1; Spider biofilm induced CAALFM_C202440WA Ortholog(s) have Rab GTPase binding, Ras guanyl-nucleotide exchange factor activity, phosphatidylinositol binding activity CAALFM_C202450CA Putative U3 snoRNP protein; Ssr1-induced; repressed by prostaglandins; heterozygous null mutant is resistant to parnafungin CAALFM_C202460WA 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), conversion of 2,3-oxidosqualene to lanosterol in sterol biosynthesis; fluconazole-induced; possibly essential, disruptants not obtained by UAU1 method; rat catheter biofilm induced CAALFM_C202470CA Putative fungal-specific transmembrane protein CAALFM_C202490CA Ortholog(s) have endoplasmic reticulum, fungal-type vacuole membrane, vacuole-mitochondrion membrane contact site localization CAALFM_C202500WA Putative TFIID subunit involved in RNA polymerase II transcription initiation; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C202510WA Phosphoribosylpyrophosphate synthetase; enzyme of purine, pyrimidine, histidine, and tryptophan biosynthesis; essential; flucytosine induced; macrophage/pseudohyphal-induced CAALFM_C202520WA Ortholog(s) have nuclear localization sequence binding, ubiquitin binding activity, role in response to ethanol and cytosol localization CAALFM_C202530WA Has domain(s) with predicted sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding, zinc ion binding activity and role in regulation of transcription, DNA-templated CAALFM_C202540WA Ortholog of S. cereviaie Rrp5, an RNA binding protein involved in synthesis of 18S and 5.8S rRNAs; Hap43-induced gene CAALFM_C202550CA Protein of unknown function; Spider biofilm induced CAALFM_C202570WA Predicted membrane transporter; member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); mRNA binds She3 CAALFM_C202580WA Predicted MFS membrane transporter; monocarboxylate porter family member; colony morphology-related gene regulation by Ssn6; flow model biofilm induced; Spider biofilm induced CAALFM_C202590WA Zinc transporter; ciclopirox olamine, fluconazole, alkaline repressed; transcript induced by amphotericin B, interaction with macrophages; possibly essential (UAU1 method); induced in oralpharyngeal candidiasis; Spider biofilm induced CAALFM_C202600CA Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation, Hap43p; almost identical to orf19.5797 CAALFM_C202610CA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; regulated by Nrg1 CAALFM_C202620WA Putative mitochondrial protein of unknown function; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C202630WA Putative transcription factor component of the core factor (CF) rDNA transcription factor complex; Spider biofilm induced CAALFM_C202640CA Has domain(s) with predicted catalytic activity, pyridoxal phosphate binding activity and role in biosynthetic process CAALFM_C202660WA Ortholog of C. dubliniensis CD36 : Cd36_17700, C. parapsilosis CDC317 : CPAR2_212340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_101113 and Debaryomyces hansenii CBS767 : DEHA2G03784g CAALFM_C202670CA Ortholog(s) have cytoplasm, mating projection tip localization CAALFM_C202680WA Fungal-specific protein (no human or murine homolog); role in sensitivity to fluconazole, specifically CAALFM_C202690WA Ortholog(s) have phosphoserine phosphatase activity, role in L-serine biosynthetic process and cytoplasm, nucleus localization CAALFM_C202700CA Ortholog(s) have 4-amino-4-deoxychorismate lyase activity, role in folic acid biosynthetic process and cytoplasm localization CAALFM_C202710CA Ortholog(s) have role in rRNA processing, ribosomal small subunit assembly and CURI complex, UTP-C complex, cytosol localization CAALFM_C202720WA Ortholog(s) have protein transporter activity, role in mRNA export from nucleus and cytoplasm, nucleus localization CAALFM_C202730WA Ortholog(s) have polyubiquitin binding activity CAALFM_C202740CA Putative hypoxanthine-guanine phosphoribosyltransferase; protein abundance affected by URA3 expression in the CAI4 strain background; protein level decreases in stationary phase; Spider biofilm induced CAALFM_C202750CA Ortholog of C. parapsilosis CDC317 : CPAR2_212260, C. dubliniensis CD36 : Cd36_17620, Candida orthopsilosis Co 90-125 : CORT_0A11590 and Candida tropicalis MYA-3404 : CTRG_01348 CAALFM_C202760WA Protein similar to S. cerevisiae Hsp70p; predicted Kex2p substrate; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed CAALFM_C202770WA Ortholog(s) have mRNA binding, pre-mRNA branch point binding activity, role in mRNA branch site recognition, mRNA cis splicing, via spliceosome and U2-type prespliceosome, U2AF, commitment complex localization CAALFM_C202780CA Ortholog(s) have GTPase activator activity CAALFM_C202790CA Predicted amino acid transmembrane transporter; rat catheter biofilm repressed CAALFM_C202800WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and ER to Golgi transport vesicle, endoplasmic reticulum membrane, integral component of Golgi membrane localization CAALFM_C202810CA Beta subunit of NC2, heterodimeric regulator of transcription; activates CDR1 transcription; possibly an essential gene, disruptants not obtained by UAU1 method; conditional mutants show decreased susceptibility to azoles CAALFM_C202820CA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C202830CA Putative small tetratricopeptide repeat (TPR)-containing protein; protein abundance is affected by URA3 expression in the CAI-4 strain background; Mig1-regulated CAALFM_C202840CA Ortholog of S. cerevisiae : YML002W, C. glabrata CBS138 : CAGL0L07634g, C. dubliniensis CD36 : Cd36_17530, C. parapsilosis CDC317 : CPAR2_212430 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_128807 CAALFM_C202850WA Putative GABA-specific permease; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 CAALFM_C202860WA Putative ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider and flow model biofilm induced CAALFM_C202870WA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity and role in ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport CAALFM_C202880CA Putative NADPH oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; oxidative stress-induced via Cap1p CAALFM_C202890WA Putative glycerol-3-phosphate acyltransferase; fungal-specific (no human or murine homolog) CAALFM_C202900WA Protein of unknown function; Spider biofilm induced CAALFM_C202910WA Protein of unknown function CAALFM_C202920WA Putative adhesin-like protein; upregulated during growth in the mouse cecum; flow model, rat catheter and Spider biofilm induced CAALFM_C202930CA Ortholog of S. cerevisiae Ett1, a nuclear protein that inhibits replication of Brome mosaic virus; early-stage flow model biofilm induced CAALFM_C202940WA Putative uroporphyrin-3 C-methyltransferase, methionine biosynthesis enzyme; upregulated by human whole blood or polymorphonuclear (PMN) cells; Hog1p-induced; fungal-specific (no human or murine homolog); Hap43p-repressed CAALFM_C202950WA Putative arylformamidase, enzyme of the NAD biosynthesis pathway; Gcn4p-regulated CAALFM_C202960CA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine dimethylation, positive regulation of translational termination and cytosol, nucleus localization CAALFM_C202970CA NAD-aldehyde dehydrogenase; decreased expression in fluconazole-resistant isolate, or in hyphae; biofilm induced; fluconazole-downregulated; protein abundance is affected by URA3 expression in the CAI-4 strain; stationary phase enriched CAALFM_C202980CA Putative D-lactate dehydrogenase; white cell-specific trancript; colony morphology-related gene regulation by Ssn6; Hap43-repressed; rat catheter biofilm induced; Spider biofilm repressed CAALFM_C202990CA Putative hydantoin utilization protein A; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p CAALFM_C203000CA Ortholog(s) have role in maturation of SSU-rRNA and cytoplasm, nucleus localization CAALFM_C203010CA Ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; ciclopirox olamine, fluconazole or flucytosine induced; regulated by Sef1, Sfu1, and Hap43 CAALFM_C203020CA Ortholog(s) have cytoplasm localization CAALFM_C203030WA DNA ligase; mRNA detected in yeast-form and pseudohyphal cells, induced upon hyphal induction; suppresses S. cerevisiae ime1-1 mutant IME2 transcription defect; required for wild-type filamentous growth and wild-type pathogenesis CAALFM_C203040WA Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1 and Tup1; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical CAALFM_C203050WA Protein with similarity to S. cerevisiae She9p, which inhibits growth when overproduced; gene has possible growth-regulation element; fungal-specific (no human or murine homolog) CAALFM_C203060WA Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium) CAALFM_C203070CA Mannosyltransferase of glycosylphosphatidylinositol (GPI) biosynthesis; catalyzes mannosylation of Man3-GPI precursor; essential for viability; 8-9 transmembrane regions predicted; has HQEXRF motif; functional homolog of S. cerevisiae Smp3p CAALFM_C203080WA Putative mitochondrial NAD-isocitrate dehydrogenase subunit; induced by ciclopirox; induced in high iron; present in exponential and stationary growth phases; Spider biofilm repressed CAALFM_C203090CA Putative phosphoribosylglycinamide formyl-transferase, enzyme of amino acid biosynthesis pathway; upregulated in biofilm; S. cerevisiae ortholog is Gcn4p regulated; protein enriched in stationary phase yeast-form cultures CAALFM_C203100WA Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human/mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; higher protein amount in stationary phase CAALFM_C203110WA Protein of unknown function; upregulated in a cyr1 or ras1 null mutant; induced by nitric oxide CAALFM_C203120WA Putative peroxisomal copper amine oxidase CAALFM_C203130WA Ortholog(s) have protein-arginine omega-N monomethyltransferase activity and role in peptidyl-arginine methylation CAALFM_C203140CA Ortholog(s) have mitochondrion localization CAALFM_C203150CA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C203160CA Ribonucleotide reductase large subunit; induced in low iron; transposon mutation affects filamentous growth; farnesol upregulated in biofilm; regulated by cell cycle, tyrosol, cell density; regulated by Sef1, Sfu1, and Hap43 CAALFM_C203170WA Protein of unknown function; F-12/CO2 early biofilm induced CAALFM_C203180CA Putative E3 ubiquitin ligase; transcript regulated by Nrg1 and Mig1 CAALFM_C203200WA Predicted splicing factor, component of the U4/U6-U5 snRNP complex; Hap43-induced gene; rat catheter biofilm induced CAALFM_C203210WA Ortholog of C. dubliniensis CD36 : Cd36_17965, C. parapsilosis CDC317 : CPAR2_211700, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112898 and Debaryomyces hansenii CBS767 : DEHA2G05588g CAALFM_C203220CA C2H2 transcription factor; induced in core caspofungin response; colony morphology-related gene regulation by Ssn6; induced by 17-beta-estradiol, ethynyl estradiol; rat catheter and Spider biofilm induced CAALFM_C203230CA Putative protein with a predicted role in the elongation of fatty acids; amphotericin B, caspofungin repressed CAALFM_C203240CA Putative GDP/GTP exchange factor; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C203250WA Ortholog of S. cerevisiae Avt7 transporter; repressed upon adherence to polystyrene; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced CAALFM_C203260WA Ortholog(s) have cytosol, nucleus localization CAALFM_C203270WA Phosphoglycerate mutase; surface protein that binds host complement Factor H and FHL-1; antigenic; fluconazole, or amino acid starvation (3-AT) induced, farnesol-repressed; Hap43, flow model biofilm induced; Spider biofilm repressed CAALFM_C203280WA Essential component of the nuclear pore complex; sumoylation target; stationary phase enriched protein; rat catheter biofilm repressed CAALFM_C203290WA Ortholog of C. dubliniensis CD36 : Cd36_18040, C. parapsilosis CDC317 : CPAR2_211790, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109928 and Debaryomyces hansenii CBS767 : DEHA2E21010g CAALFM_C203300WA Putative porphobilinogen synthase; induced in high iron; protein level decrease in stationary phase cultures; Spider biofilm repressed CAALFM_C203310CA ESCRT III complex protein; role in multivesicular body (MVB) trafficking; required for processing of Rim8; Bcr1-repressed in RPMI a/a biofilms CAALFM_C203320WA Histidine kinase; 2-component signaling, cell wall synthesis; hyphal growth defect; avirulent in mouse, not rat vaginal infection; phagocytosis rate increased; Spider biofilm induced; required for RPMI biofilm; Bcr1-induced in a/a biofilm CAALFM_C203330CA MAP kinase of osmotic-, heavy metal-, and core stress response; role in regulation of glycerol, D-arabitol in response to stress; phosphorylated in response to H2O2 (Ssk1-dependent) or NaCl; mutant induces protective mouse immune response CAALFM_C203340WA Ortholog(s) have guanyl-nucleotide exchange factor activity, role in retrograde transport, endosome to Golgi and Golgi membrane, RIC1-RGP1 guanyl-nucleotide exchange factor complex localization CAALFM_C203350WA Putative GPI-anchored protein; exogenously expressed protein substrate for Kex2 processing in vitro; repressed by alpha pheromone in SpiderM medium; macrophage-induced; induced in oralpharyngeal candidiasis; Spider biofilm induced CAALFM_C203360WA Putative AMP deaminase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C203370WA Putative trifunctional enzyme of thiamine biosynthesis, degradation and salvage; Spider biofilm induced CAALFM_C203380WA Essential protein involved in endocytosis and polarized growth; ortholog of S. cerevisiae Pan1, which is a part of a complex that regulates actin cytoskeleton; Spider biofilm repressed CAALFM_C203390CA Heat-shock protein; regulated by macrophage response, Nrg1, Mig1, Gcn2, Gcn4, Mnl1p; heavy metal (cadmium) stress-induced; stationary phase enriched protein; rat catheter and Spider biofilm induced CAALFM_C203400CA Rim101 pathway protein that acts in Rim101 processing; regulates filamentation in response to alkaline pH; required for host tissue invasion during infection; flow model biofilm induced CAALFM_C203410WA Ortholog(s) have role in cargo loading into COPII-coated vesicle and COPII vesicle coat, cytosol, mating projection tip localization CAALFM_C203420CA Ortholog(s) have myosin binding activity, role in intracellular mRNA localization, mating type switching and cytoplasm localization CAALFM_C203430WA Subunit of the NuA4 histone acetyltransferase complex; Plc1p-regulated CAALFM_C203440WA Putative GPI-anchored protein of unknown function; Spider biofilm repressed CAALFM_C203450WA Protein required for respiratory growth CAALFM_C203460CA Predicted mitochondrial i-AAA protease supercomplex; degrades misfolded mitochondrial proteins; Hap43-repressed gene CAALFM_C203470CA Putative cytochrome c oxidase; flucytosine induced CAALFM_C203490CA Ortholog of C. dubliniensis CD36 : Cd36_18230, Debaryomyces hansenii CBS767 : DEHA2E20636g, Pichia stipitis Pignal : PICST_66811 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_60843 CAALFM_C203500WA Ortholog(s) have GTPase activator activity, role in positive regulation of GTPase activity, positive regulation of TORC1 signaling and Lst4-Lst7 complex, vacuolar membrane localization CAALFM_C203520CA Protein of unknown function; transcription is specific to white cell type CAALFM_C203530WA Ortholog(s) have superoxide-generating NADPH oxidase activity, role in apoptotic process, regulation of actin cytoskeleton organization and perinuclear endoplasmic reticulum, ribosome localization CAALFM_C203540WA Protein similar to S. cerevisiae protein with role in nucleotide excision repair; down-regulation associated with azole resistance; Hap43p-repressed gene CAALFM_C203550CA Ortholog(s) have role in DNA recombination, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and cytosol, polysome localization CAALFM_C203560CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C203570CA Protein of unknown function; Spider biofilm induced CAALFM_C203590CA Predicted bZip transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C203600WA Putative beta-mannosyltransferase, member of a 9-gene family including characterized BMT genes with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; transposon insertion in promoter region causes decreased colony wrinkling CAALFM_C203610WA Protein with a monooxygenase domain; Spider biofilm induced CAALFM_C203620WA Putative thiol-specific monooxygenase; mutant is viable; flow model biofilm induced CAALFM_C203630WA Ortholog of C. dubliniensis CD36 : Cd36_18340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_124631, Debaryomyces hansenii CBS767 : DEHA2D04356g and Pichia stipitis Pignal : PICST_34839 CAALFM_C203640WA Putative gamma-aminobutyrate (GABA) transaminase; macrophage-induced; overlaps orf19.854.1, which is a region annotated as a blocked reading frame; Spider biofilm induced CAALFM_C203670WA Putative secreted aspartyl protease; possible Kex2 substrate; induced by low iron; repressed by alpha pheromone in SpiderM medium; possibly essential (UAU1 method); regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced CAALFM_C203680WA Glycosyl-phosphatidylinositol-anchored aspartic endopeptidase; regulated by Gcn2p and Gcn4p; expressed only in opaque MTLa/MTLa cells CAALFM_C203690CA Protein of unknown function; repressed by Rim101; negatively modulates intracellular ATP levels during the development of azole resistance; induced by Ca(2+) in a calcineurin-dependent manner; Spider biofilm induced CAALFM_C203700WA Ortholog(s) have protein-N-terminal asparagine amidohydrolase activity, protein-N-terminal glutamine amidohydrolase activity, role in cellular protein modification process, protein catabolic process and mitochondrion localization CAALFM_C203710WA Ortholog(s) have enzyme activator activity and role in protein N-linked glycosylation, protein O-linked glycosylation CAALFM_C203720WA Putative GPI-anchored protein CAALFM_C203750WA Protein similar to protease of mitochondrial inner membrane; increased transcription is observed upon benomyl treatment; macrophage-downregulated gene CAALFM_C203760CA Predicted protein kinase similar to S. cerevisiae Nnk1; implicated in proteasome function in S. cerevisiae; induced by Mnl1 under weak acid stress CAALFM_C203770CA Protein similar to S. cerevisiae Ste11p; mutants are sensitive to growth on H2O2 medium CAALFM_C203780CA Putative DNA repair exonuclease; fungal-specific (no human or murine homolog) CAALFM_C203790CA Adenylyl cyclase and stress responsive protein; induced in cyr1 or ras1 mutant; Spider biofilm induced CAALFM_C203800CA Ortholog(s) have role in Golgi vesicle transport and Golgi membrane localization CAALFM_C203810CA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C203820CA Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript possibly regulated upon hyphal formation; Spider biofilm repressed CAALFM_C203830WA Putative endoribonuclease; induced by nitric oxide independent of Yhb1p; mutation confers hypersensitivity to aureobasidin A CAALFM_C203840CA Transcription factor; activator that forms a heterodimer with Ino2; likely regulates genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis, fatty acid beta-oxidation, and peroxisome biogenesis; gene has intron CAALFM_C203870WA Glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection CAALFM_C203880CA Ortholog(s) have role in mRNA splicing, via spliceosome and U1 snRNP, U2 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol localization CAALFM_C203890WA Protein likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C203900CA Ortholog(s) have role in nucleosome mobilization and Ino80 complex, cytosol localization CAALFM_C203910CA Ortholog(s) have carbohydrate binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, role in ER-associated ubiquitin-dependent protein catabolic process and endoplasmic reticulum lumen localization CAALFM_C203920CA Major facilitator superfamily protein; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi13p, which acts in GPI anchor biosynthesis; Hap43p-induced gene CAALFM_C203930CA Ortholog of C. dubliniensis CD36 : Cd36_18570, C. parapsilosis CDC317 : CPAR2_211360, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115359 and Debaryomyces hansenii CBS767 : DEHA2D06886g CAALFM_C203940CA Protein kinase; involved in growth control, cell size, resistance to rapamycin, cations, chlamydospore formation, filamentous growth under some conditions, and virulence; prevents hyphal growth in hypoxia at high CO2; Spider biofilm induced CAALFM_C203950WA Putative ribosomal protein, large subunit, mitochondrial precursor; repressed by prostaglandins; Spider biofilm repressed CAALFM_C203960WA Ribosomal protein L39; transcript induced upon germ tube formation; colony morphology-related gene regulation by Ssn6; Hap43-induced CAALFM_C203970WA Ortholog of C. dubliniensis CD36 : Cd36_18620, C. parapsilosis CDC317 : CPAR2_212480, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115371 and Debaryomyces hansenii CBS767 : DEHA2D06798g CAALFM_C203980CA RNA polymerase II mediator complex subunit; RNA polymerase II transcription cofactor CAALFM_C203990WA Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells CAALFM_C204000CA Protein of unknown function; Spider biofilm induced CAALFM_C204010CA Small heat shock protein; role in stress response and virulence; fluconazole-downregulated; induced in cyr1 or ras1 mutant; stationary phase enriched protein; detected in some, not all, biofilm extracts; Spider biofilm induced CAALFM_C204020CA Putative protein serine-threonine phosphatase; macrophage/pseudohyphal-repressed CAALFM_C204030CA Putative mitochondrial acyl carrier protein CAALFM_C204040CA Protein similar to S. cerevisiae Ylr422wp; transposon mutation affects filamentous growth; induced by Mnl1p under weak acid stress CAALFM_C204050CA Putative guanine nucleotide exchange factor; required for embedded filamentous growth; activates Rac1; has a DOCKER domain; similar to adjacent DCK2 and to S. cerevisiae Ylr422wp; regulated by Nrg1; Spider biofilm induced CAALFM_C204060CA Amino acid sensor; required for wild-type hyphal growth on solid serum or Lees media, not under all conditions; 12 predicted membrane spanning regions; Hap43-repressed; Spider biofilm induced CAALFM_C204080WA Protein of unknown function; mutants are viable; Hap43-induced gene; oxidative stress-induced via Cap1; rat catheter and Spider biofilm induced CAALFM_C204090WA Ortholog of C. dubliniensis CD36 : Cd36_18730, C. parapsilosis CDC317 : CPAR2_212510, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135843 and Debaryomyces hansenii CBS767 : DEHA2D06732g CAALFM_C204100WA Protein of unknown function; mutant is viable; Hap43-repressed CAALFM_C204110WA Ortholog(s) have DNA helicase activity, role in DNA unwinding involved in DNA replication, reciprocal meiotic recombination, synapsis and nucleus localization CAALFM_C204120CA Ortholog(s) have role in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, preribosome, large subunit precursor localization CAALFM_C204130WA Ortholog(s) have role in histone deacetylation, negative regulation of chromatin silencing at rDNA and negative regulation of chromatin silencing at silent mating-type cassette, more CAALFM_C204140WA Putative chitin biosynthesis protein; fungal-specific; repressed upon yeast-to-hypha switch; rat catheter biofilm repressed CAALFM_C204150CA Putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p CAALFM_C204160WA Putative protein of unknown function; possibly mitochondrial; Hap43-repressed; Spider biofilm repressed CAALFM_C204170CA Ortholog of S. cerevisiae : YPR010C-A, C. glabrata CBS138 : CAGL0J01699g, C. dubliniensis CD36 : Cd36_02990, C. parapsilosis CDC317 : CPAR2_211020 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_116148 CAALFM_C204180CA Putative mitochondrial carrier family transporter; rat catheter biofilm induced CAALFM_C204190CA Putative GABA transaminase; transcription regulated by Mig1 and Tup1; stationary phase enriched protein; rat catheter and Spider biofilm induced CAALFM_C204200WA Essential transcription factor; induces ribosomal protein genes and the rDNA locus; acts with Cbf1 at subset of promoters; recruits Fhl1 and Ifh1 to promoters; role is analogous to that of S. cerevisiae Rap1; Spider biofilm induced CAALFM_C204210WA Beta subunit of heterotrimeric G protein of mating signal transduction pathway; required for mating; transcript is specific to cells homozygous at MTL; induced by alpha pheromone; ortholog of S. cerevisiae Ste4 CAALFM_C204220CA Putative DNA-binding transcription factor; TFIIF subunit; macrophage-induced protein; possibly required for yeast cell adherence to silicone substrate; mutant has pleiotrophic effects CAALFM_C204230WA Putative branched chain amino acid aminotransferase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-aminotriazole treatment); early-stage flow model biofilm formation CAALFM_C204240CA Protein of RAM cell wall integrity signaling network; involved in regulation of Ace2 activity and cellular morphogenesis; role in cell separation, azole sensitivity; required for hyphal growth CAALFM_C204250WA ESCRT II protein sorting complex subunit; involved in Rim8 processing and proteolytic activation of Rim101, which regulates pH response; role in uptake of Histatin-5 into vacuole CAALFM_C204260WA Putative cyclin-dependent protein kinase; mutants are sensitive to growth on H2O2 medium CAALFM_C204270WA Monomeric CDK-activating kinase; functional homolog of S. cerevisiae Cak1p; phosphorylates cyclin-free human CDK2; lacks glycine loop motif; conserved lysine (K36) not required for activity; possibly essential gene (by UAU1 method) CAALFM_C204280WA Ortholog(s) have protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity CAALFM_C204290WA Ortholog of S. cerevisiae Rim11; a protein kinase involved in meiosis and sporulation in S. cerevisiae; mutant is viable CAALFM_C204300CA Protein of unknown function; Spider biofilm induced CAALFM_C204310WA Acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in protein abundance associated with azole resistance; fluconazole or ketoconazole induced; macrophage-downregulated protein; GlcNAc-induced protein CAALFM_C204320WA Ortholog of C. dubliniensis CD36 : Cd36_18970, C. parapsilosis CDC317 : CPAR2_212800, Debaryomyces hansenii CBS767 : DEHA2F08690g and Candida guilliermondii ATCC 6260 : PGUG_01488 CAALFM_C204330CA S. cerevisiae ortholog Env9 has similarity to oxidoreductases and is proposed to have vacuolar functions, found in lipid particles; hyphal-induced expression CAALFM_C204340CA Putative gluconokinase; rat catheter biofilm induced CAALFM_C204350CA RNA helicase; mitochondrial RNA catabolism; required for chlamydospore formation, embedded hyphal growth, wild-type respiratory growth, alkaline-induced morphogenesis and SD or Spider biofilm formation; rat catheter biofilm induced CAALFM_C204360WA Protein kinase of unknown function; mutants are viable CAALFM_C204370WA Protein of unknown function; Hap43-induced gene CAALFM_C204380CA Ortholog(s) have tetrahydrofolylpolyglutamate synthase activity, role in one-carbon metabolic process, regulation of DNA methylation and cytosol, mitochondrion, nucleus localization CAALFM_C204390WA Predicted protein with similarity to cell wall proteins; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C204400WA Protein of unknown function; mutants are viable; rat catheter and Spider biofilm induced CAALFM_C204410WA Ortholog of Candida albicans WO-1 : CAWG_04197 CAALFM_C204420WA Protein of unknown function; oxidative stress-induced via Cap1 CAALFM_C204430WA Protein of unknown function CAALFM_C204440WA Ortholog of Candida albicans WO-1 : CAWG_04200 CAALFM_C204450WA Protein of unknown function; Hap43-repressed; rat catheter biofilm repressed CAALFM_C204460WA Homocitrate synthase, minor isoform; repressed by nitric oxide and by hypoxia; protein level decreases in stationary phase cultures; induced by ketoconazole, Spider biofilm induced; flow model biofilm repressed CAALFM_C204470WA Putative NAD-dependent (R,R)-butanediol dehydrogenase; regulated by white-opaque switch; induced by nitric oxide independent of Yhb1; Spider biofilm induced CAALFM_C204480WA Has domain(s) with predicted oxidoreductase activity, zinc ion binding activity and role in oxidation-reduction process CAALFM_C204490WA Similar to HMG-box variant of S. pombe; Spider biofilm repressed CAALFM_C204500WA Ortholog(s) have ATPase activity, DNA binding, TBP-class protein binding activity CAALFM_C204510WA Putative mitochondrial carrier protein; induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C204520CA Ortholog of C. dubliniensis CD36 : Cd36_19120, C. parapsilosis CDC317 : CPAR2_103880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115581 and Debaryomyces hansenii CBS767 : DEHA2F08426g CAALFM_C204530WA Ortholog(s) have RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription corepressor activity, TBP-class protein binding, structural molecule activity CAALFM_C204540CA Predicted Golgi Ca2+/H+ exchanger, involved in regulation of calcium homeostasis CAALFM_C204550CA Nicotinamide adenine dinucleotide dehydrogenase complex I subunit of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline repressed; Hap43-repressed; Spider biofilm repressed CAALFM_C204560WA Mannosyltransferase; transcription elevated in chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C204570WA Ortholog(s) have mRNA binding activity, role in nuclear division, rRNA processing, ribosomal large subunit biogenesis and mitotic spindle pole body, nuclear periphery, nucleolus, preribosome, large subunit precursor localization CAALFM_C204580WA Putative farnesyl pyrophosphate synthetase involved in isoprenoid and sterol biosynthesis, based on similarity to S. cerevisiae Erg20p; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C204590CA Putative ubiquinol cytochrome c reductase; macrophage and pseudohyphal-induced protein; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Spider biofilm repressed CAALFM_C204600CA Ribosomal protein L17; mutation confers hypersensitivity to 5-FU, tubercidin; repressed upon phagocytosis by macrophage; Hap43-induced; Spider biofilm repressed CAALFM_C204620WA Predicted ortholog of S. cerevisiae Swi3, subunit of the SWI/SNF chromatin remodeling complex; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C204640CA Protein similar to S. cerevisiae Snu114p, which is an RNA helicase involved in pre-mRNA splicing; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C204650CA Protein similar to S. cerevisiae Rpb4p, which is a component of RNA polymerase II; transposon mutation affects filamentous growth CAALFM_C204660CA Predicted serine-threonine protein kinase; involved in hyphal growth regulation and biofilm formation; flow model biofilm induced; induced in core caspofungin response CAALFM_C204670WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C204680WA Predicted component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex), involved in protein import into mitochondria CAALFM_C204690CA Putative polyamine transporter; mutation confers hypersensitivity to toxic ergosterol analog; hyphal induced; macrophage induced CAALFM_C204700CA Putative ortholog of S. cerevisiae Utp30; a U3-containing 90S preribosome complex protein; Hap43-induced; Spider biofilm induced CAALFM_C204710CA Functional homolog of S. cerevisiae Ure2p, which is a regulator of nitrogen utilization, and which also has an infectious prion form called [URE3]; forms [URE3] prion when expressed in S. cerevisiae CAALFM_C204720CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Hap43p-repressed gene CAALFM_C204730WA Ortholog of C. dubliniensis CD36 : Cd36_19300, C. parapsilosis CDC317 : CPAR2_209720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114035 and Debaryomyces hansenii CBS767 : DEHA2E10494g CAALFM_C204740CA Ortholog of C. dubliniensis CD36 : Cd36_19310, C. parapsilosis CDC317 : CPAR2_209710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113479 and Debaryomyces hansenii CBS767 : DEHA2C15114g CAALFM_C204750WA Ortholog of C. dubliniensis CD36 : Cd36_19320, C. parapsilosis CDC317 : CPAR2_209670, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113478 and Debaryomyces hansenii CBS767 : DEHA2C15136g CAALFM_C204760WA Member of the GCK-III subfamily of eukaryotic Ste20p kinases; in RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; constitutive expression is MTL, white-opaque independent CAALFM_C204770WA Ortholog(s) have role in endoplasmic reticulum organization, histone exchange and Swr1 complex, mitochondrion localization CAALFM_C204780WA Ortholog of Candida albicans WO-1 : CAWG_04234 CAALFM_C204790CA Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translational initiation and mitochondrial small ribosomal subunit localization CAALFM_C204800CA Predicted component of the mitochondrial sorting and assembly machinery (SAM complex) and ER-mitochondria encounter structure (ERMES) complex with a role in protein import into mitochondria CAALFM_C204810WA Imidazoleglycerol-phosphate dehydratase, enzyme of histidine biosynthesis; functionally complements S. cerevisiae his3-1 mutation; hyphal-induced expression; regulated by Gcn2p and Gcn4p; fungal-specific (no human or murine homolog) CAALFM_C204820WA Ortholog(s) have rRNA (guanine-N1-)-methyltransferase activity, role in rRNA modification and mitochondrion localization CAALFM_C204830WA Ortholog of C. dubliniensis CD36 : Cd36_19390, C. parapsilosis CDC317 : CPAR2_209600, Candida tenuis NRRL Y-1498 : CANTEDRAFT_134010 and Debaryomyces hansenii CBS767 : DEHA2C14960g CAALFM_C204850CA Ortholog(s) have actin filament binding activity, role in actin cortical patch localization, actin filament bundle assembly, endocytosis and actin cortical patch localization CAALFM_C204860WA C2H2 transcription factor; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_C204870CA Putative THO complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method; protein newly produced during adaptation to the serum CAALFM_C204880CA Putative adrenodoxin-NADPH oxidoreductase; role in heme biosynthesis CAALFM_C204930CA Protein kinase of the Cdc2 subfamily involved in hyphal development, virulence; promotes hyphal development independently of Cph1 and Efg1; functionally complements pheromone hypersensitivity of S. cerevisiae sgv1 mutant; Hap43p-repressed CAALFM_C204940CA MFS inositol transporter; uptake of exogenous inositol; 12 transmembrane motifs; expressed in rich medium; fluconazole, caspofungin repressed; possibly essential (UAU1 method); flow model, rat catheter and Spider biofilm induced CAALFM_C204950CA Cytochrome c1; induced in high iron; alkaline repressed; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider biofilm repressed CAALFM_C204960CA Protein of unknown function; Spider biofilm induced CAALFM_C204970WA Putative alpha-actinin-like protein; induced by alpha pheromone in SpiderM medium CAALFM_C204980CA Catalytic alpha-subunit of protein kinase CK2; interaction with calcineurin pathway affects fluconazole sensitivity; synthetically lethal with CKA1; attenuated virulence in a mouse oropharyngeal candidiasis but not in a systemic mouse model CAALFM_C204990WA Ortholog(s) have role in regulation of DNA-dependent DNA replication initiation and DNA replication preinitiation complex, chromosome, centromeric region, endoplasmic reticulum, nuclear envelope, spindle pole body localization CAALFM_C205000CA Putative mitochondrial large subunit ribosomal protein; colony morphology-related gene regulation by Ssn6 CAALFM_C205020WA Ortholog(s) have role in ascospore formation, mitochondrion organization, positive regulation of transcription from RNA polymerase II promoter CAALFM_C205030CA Putative Rho family GTPase; possible substrate of protein farnesyltransferase and geranylgeranyltransferase type I; greater transcription in hyphal form than yeast form; plasma membrane-localized CAALFM_C205040CA Ortholog(s) have cellular bud neck, fungal-type vacuole localization CAALFM_C205050CA Ortholog(s) have acetylglucosaminyltransferase activity, role in protein N-linked glycosylation and Golgi medial cisterna localization CAALFM_C205060CA Putative sulfiredoxin; regulated by Tsa1, Tsa1B in minimal media at 37 degrees C; flow model biofilm induced; Spider biofilm induced CAALFM_C205070WA Ferric reductase; alkaline induced; ciclopirox olamine; Hap43-induced CAALFM_C205080CA Predicted nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; Spider biofilm induced CAALFM_C205090WA Putative nucleolar DEAD-box RNA helicase; oxidative stress-repressed via Cap1; repressed by prostaglandins CAALFM_C205100CA Putative translation release factor 1, which interacts with stop codons and promotes release of nascent peptides from ribosomes; Hap43p-induced gene CAALFM_C205110WA Putative membrane protein; mutation increases resistance to miltefosine; early-stage flow model biofilm induced CAALFM_C205130WA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C205140WA Ortholog(s) have protein serine/threonine kinase activity CAALFM_C205150WA Ortholog(s) have ubiquitin-protein transferase activity, role in protein import into peroxisome matrix, protein polyubiquitination and peroxisomal importomer complex, peroxisomal membrane localization CAALFM_C205160CA Ortholog(s) have mRNA 3'-UTR binding, translation repressor activity, nucleic acid binding activity, role in negative regulation of translation, ribosomal large subunit biogenesis and large ribosomal subunit, nucleolus localization CAALFM_C205170WA Ortholog(s) have mitochondrial inner membrane localization CAALFM_C205180WA White-phase yeast transcript; expression in opaques increases virulence/switching; mutant switches as WT; Hap43, hypoxia, ketoconazol induced; required for RPMI biofilm; Bcr1-induced in RPMI a/a biofilm; rat catheter, Spider biofilm induced CAALFM_C205190WA Putative thymidylate synthase; flucytosine induced; rat catheter biofilm repressed; Spider biofilm repressed CAALFM_C205200CA Component of the spindle checkpoint; cell-cycle regulated periodic mRNA expression CAALFM_C205210WA Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C205220CA Ortholog(s) have structural constituent of nuclear pore activity CAALFM_C205230CA Putative pre-rRNA processing protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C205250CA Aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing; farnesol-, Hap43p-induced; GlcNAc-induced CAALFM_C205260WA Putative SH3-domain-containing protein; predicted role in bud-site selection; Spider biofilm induced CAALFM_C205270WA Transportin or cytosolic karyopherin beta; Spider biofilm induced CAALFM_C205280CA Subunit of GPI-GlcNAc transferase; role in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in GPI anchor synthesis; complements S. cerevisiae gpi19 mutant; flow model biofilm induced CAALFM_C205290CA Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization CAALFM_C205300CA S. cerevisiae ortholog Mrps35p is a structural constituent of ribosome and localizes to mitochondrial small ribosomal subunit; the snoRNA CD39 is encoded within the MRPS35 intron CAALFM_C205320WA Putative kinase; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C205330CA Ortholog of C. dubliniensis CD36 : Cd36_19810, C. parapsilosis CDC317 : CPAR2_206450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113905 and Debaryomyces hansenii CBS767 : DEHA2C05566g CAALFM_C205340CA Putative RNA polymerase; protein level decreases in stationary phase cultures; Hap43p-induced gene CAALFM_C205350CA Ortholog of C. dubliniensis CD36 : Cd36_19830, C. parapsilosis CDC317 : CPAR2_206470, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113899 and Debaryomyces hansenii CBS767 : DEHA2C05676g CAALFM_C205360CA Putative class III aminotransferase with a predicted role in biotin biosynthesis; Spider biofilm induced CAALFM_C205370CA Putative transcriptional repressor CAALFM_C205380WA Protein of unknown function; S. cerevisiae YLR407W mutants have abnormal budding; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced CAALFM_C205390CA Ortholog of C. dubliniensis CD36 : Cd36_19870, C. parapsilosis CDC317 : CPAR2_209420, Candida tenuis NRRL Y-1498 : CANTEDRAFT_100922 and Debaryomyces hansenii CBS767 : DEHA2D11176g CAALFM_C205400WA Ortholog of C. dubliniensis CD36 : Cd36_19880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117672, Debaryomyces hansenii CBS767 : DEHA2D11154g and Pichia stipitis Pignal : PICST_59570 CAALFM_C205410WA Ribosomal 60S subunit protein L31B; Spider biofilm repressed CAALFM_C205440WA Ortholog(s) have ATPase activity, protein heterodimerization activity, role in fatty acid metabolic process, protein import into peroxisome matrix, receptor recycling, replicative cell aging and cytosol, nucleus, peroxisome localization CAALFM_C205450CA Predicted component of the mitochondrial import motor; involved in protein import into mitochondrial matrix; early-stage flow model biofilm induced CAALFM_C205460WA Pyruvate kinase at yeast cell surface; Gcn4/Hog1/GlcNAc regulated; Hap43/polystyrene adherence induced; repressed by phagocytosis/farnesol; hyphal growth role; stationary phase enriched; flow model biofilm induced; Spider biofilm repressed CAALFM_C205470WA Putative methyltransferase of ubiquinone biosynthesis; regulated by Gcn4; repressed by amino acid starvation (3-AT), Hap43; induced upon adherence to polystyrene; Spider biofilm repressed CAALFM_C205480CA Ortholog(s) have mitochondrial intermembrane space localization CAALFM_C205490WA Ortholog of C. dubliniensis CD36 : Cd36_19950, C. parapsilosis CDC317 : CPAR2_104135, Candida tenuis NRRL Y-1498 : cten_CGOB_00075 and Debaryomyces hansenii CBS767 : DEHA2F07964g CAALFM_C205500WA Putative F0-ATP synthase subunit 4; macrophage/pseudohyphal-induced; present in exponential and stationary growth phases CAALFM_C205510CA Ortholog(s) have histone binding activity, role in DNA replication-dependent nucleosome assembly and CAF-1 complex, cytoplasm, nucleus localization CAALFM_C205520WA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine dimethylation, peptidyl-lysine monomethylation, vesicle-mediated transport and cytosol, nucleus localization CAALFM_C205530CA Ortholog(s) have role in protein export from nucleus, regulation of chromatin silencing at telomere, ribosomal small subunit export from nucleus and cytosol, nuclear pore, nucleus localization CAALFM_C205540CA Putative U1-70K component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae SNP1; downregulated upon adherence to polystyrene CAALFM_C205550WA Protein with a predicted cytochrome b5-like heme/steroid binding domain; repressed by alpha pheromone in SpiderM medium CAALFM_C205560WA Putative NADPH-dependent methylglyoxal reductase; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media CAALFM_C205570CA Putative lipid raft associated protein; Spider biofilm induced CAALFM_C205580WA Protein of unknown function; Hap43-induced; flow model biofilm repressed CAALFM_C205590CA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C205610CA Small 40S ribosomal subunit protein; induced by ciclopirox olamine; repressed upon phagocytosis by murine macrophage; 5'-UTR intron; Hap43-induced; Spider biofilm repressed CAALFM_C205620WA Zn-ribbon protein; required for synthesis of diphthamide on translation factor eEF2; involved in modification of wobble nucleosides in tRNAs; rat catheter and Spider biofilm induced CAALFM_C205640WA Putative helix-loop-helix (HLH) transcription factor with a role in filamentous growth CAALFM_C205650WA Putative role in vacuolar sorting; downregulated in biofilm; induced upon adherence to polystyrene CAALFM_C205660WA Putative peptide:N-glycanase; gene has variable numbers of 12-bp repeats; induced by caspofungin, ciclopirox olamine, ketoconazole or hypoxia; gene of core caspofungin response; Hap43-induced; Spider biofilm induced CAALFM_C205670CA Ortholog(s) have tRNA-intron endonuclease activity, role in tRNA-type intron splice site recognition and cleavage and mitochondrial outer membrane, tRNA-intron endonuclease complex localization CAALFM_C205680WA Ortholog(s) have role in CVT pathway, establishment of cell polarity, filamentous growth of a population of unicellular organisms, macroautophagy, pexophagy, retrograde transport, vesicle recycling within Golgi CAALFM_C205690CA Putative mRNA cleavage and polyadenylation specificity factor; transcription is regulated upon yeast-hyphal switch; decreased expression in hyphae compared to yeast-form cells; fluconazole or flucytosine induced CAALFM_C205700WA Putative flavoprotein subunit of fumarate reductase; soluble protein in hyphae; caspofungin repressed; stationary phase enriched protein; flow model biofilm induced; Spider biofilm repressed CAALFM_C205710CA Ribosomal 60S subunit protein; Spider biofilm repressed CAALFM_C205720CA Putative oxysterol binding protein family; probable peripheral membrane protein of the Golgi complex; flow model and Spider biofilm repressed CAALFM_C205730CA Inositol acyltransferase with role in early steps of GPI anchor biosynthetic process; antifungal drug target CAALFM_C205740WA Putative regulatory subunit of Nem1-Spo7 phosphatase holoenzyme that regulates nuclear growth by controling phospholipid biosynthesis; induced by alpha pheromone in SpiderM medium CAALFM_C205750WA Ortholog(s) have rRNA binding activity, role in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit export from nucleus and nucleolus localization CAALFM_C205760CA Predicted ORF from Assembly 19; repressed by nitric oxide; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C205770WA Zn(II)2Cys6 domain transcription factor; regulated by Mig1 and Tup1; rat catheter and Spider biofilm induced CAALFM_C205780CA Ortholog of S. cerevisiae Mkk2; MAP kinase kinase involved in signal transduction; macrophage-downregulated; mutants are viable and hypersensitive to caspofungin CAALFM_C205790CA Putative DNA replication factor C subunit; ortholog of S. cerviaie Rfc1; likely essential, based on an insertional mutagenesis strategy; rat catheter biofilm repressed CAALFM_C205800CA Ortholog(s) have GTPase binding activity, role in ER to Golgi vesicle-mediated transport and Golgi membrane localization CAALFM_C205810WA Ortholog(s) have role in cellular response to methylmercury and cytoplasm, nucleus localization CAALFM_C205820WA Protein of unknown function; Hap43-repressed gene CAALFM_C205830CA Putative chaperone protein; role in the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; Spider biofilm induced CAALFM_C205840WA Predicted diphthamide biosynthesis protein; Spider biofilm induced CAALFM_C205850CA Ortholog(s) have role in CVT pathway, intra-Golgi vesicle-mediated transport and Golgi transport complex localization CAALFM_C205860CA Putative Xbp1 transcriptional repressor; binds to cyclin gene promoters in S. cerevisiae; Hap43-repressed; possibly essential, disruptants not obtained by UAU1 method CAALFM_C205870WA Protein conserved in C. dublinensis CAALFM_C205890CA Putative isocitrate dehydrogenase; transcriptionally induced by interaction with macrophage; alkaline induced; Spider biofilm repressed CAALFM_C205900WA Ortholog(s) have SUMO transferase activity, role in protein sumoylation, reciprocal meiotic recombination, synaptonemal complex assembly and condensed nuclear chromosome localization CAALFM_C205910WA Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis CAALFM_C205920CA Putative cytochrome c oxidase; flucytosine induced; caspofungin repressed CAALFM_C205930WA Putative subunit VIIa of cytochrome c oxidase; flucytosine induced CAALFM_C205940CA Ortholog(s) have ATP binding, phosphatidylinositol binding activity CAALFM_C205950CA Putative acyl-CoA thioesterase; Hap43-repressed; Spider biofilm induced CAALFM_C205960CA Ortholog of C. parapsilosis CDC317 : CPAR2_209840, C. dubliniensis CD36 : Cd36_20380, Lodderomyces elongisporus NRLL YB-4239 : LELG_00983 and Candida orthopsilosis Co 90-125 : CORT_0A09100 CAALFM_C205970CA Putative acyl-CoA thioesterase CAALFM_C205980CA Ortholog(s) have acyl-CoA hydrolase activity, role in fatty acid beta-oxidation and mitochondrion, peroxisome localization CAALFM_C205990CA Predicted thioesterase/thiol ester dehydrase-isomerase; Spider biofilm induced CAALFM_C206000WA Putative bud formation and morphogenesis protein; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); macrophage-induced; Spider biofilm induced CAALFM_C206010WA Protein described as similar to S. cerevisiae sporulation protein; ortholog of S. cerevisiae Atg2, an autophagic vesicle formation protein; up-regulation associated with azole resistance; Spider biofilm induced CAALFM_C206020WA CNT family H(+)/nucleoside symporter; transports adenosine, uridine, inosine, guanosine, tubercidin; variant alleles for high/low-affinity isoforms; S or G at residue 328 affects specificity; Spider, flow model biofilm induced CAALFM_C206030WA Ortholog of C. dubliniensis CD36 : Cd36_20450, C. parapsilosis CDC317 : CPAR2_104160, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95516 and Debaryomyces hansenii CBS767 : DEHA2F05192g CAALFM_C206040CA Ortholog(s) have N-acetyltransferase activity, role in response to drug and nuclear envelope, plasma membrane localization CAALFM_C206070WA Predicted long chain fatty acid CoA ligase; upregulated upon phagocytosis; induced by nitric oxide independent of Yhb1 CAALFM_C206080CA Ortholog(s) have 8-oxo-dGDP phosphatase activity CAALFM_C206090WA Ortholog of C. dubliniensis CD36 : Cd36_20490, C. parapsilosis CDC317 : CPAR2_104180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116074 and Debaryomyces hansenii CBS767 : DEHA2F05148g CAALFM_C206100WA Protein mannosyltransferase; required for WT cell wall composition and virulence in mice; roles in hyphal growth and drug sensitivity; one of 5 family members; Axl2 a substrate; Spider biofilm repressed; Bcr1-repressed in RPMI a/a biofilm CAALFM_C206110WA Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; Spider biofilm repressed CAALFM_C206120CA Ortholog of S. cerevisiae : YJR141W, C. glabrata CBS138 : CAGL0M00264g, C. dubliniensis CD36 : Cd36_20520, C. parapsilosis CDC317 : CPAR2_104880 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_126860 CAALFM_C206130WA Putative subunit of a replication fork-pausing checkpoint complex CAALFM_C206140CA Ortholog of C. dubliniensis CD36 : Cd36_20540, C. parapsilosis CDC317 : CPAR2_104860, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116071 and Pichia stipitis Pignal : PICST_32327 CAALFM_C206150CA Putative 19S regulatory particle of the 26S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2 and Gcn4; Spider biofilm repressed CAALFM_C206160WA Ortholog of C. parapsilosis CDC317 : CPAR2_104840, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116070, Debaryomyces hansenii CBS767 : DEHA2F04994g and Pichia stipitis Pignal : psti_CGOB_00085 CAALFM_C206170CA Putative sulfite reductase beta subunit; role in cell wall biogenesis; regulated by Tsa1/Tsa1B in H2O2 stress; Gcn4-regulated; Tbf1-activated; Hap43-repressed; Spider, flow, F-12/CO2 model biofilm induced CAALFM_C206180CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; flow model biofilm induced CAALFM_C206190WA Putative threonine dehydratase; regulated by Gcn4 and Gcn2; induced by amino acid starvation (3-AT); protein present in yeast exponential and stationary phase cultures; early-stage flow model biofilm induced CAALFM_C206200CA Ortholog(s) have GTPase activity, ribosome binding activity, role in positive regulation of translation and mitochondrial matrix, mitochondrial ribosome localization CAALFM_C206210CA Putative 3-phosphoserine aminotransferase; predicted role in serine and glycine biosynthesis; protein present in exponential and stationary yeast growth phases; Spider biofilm repressed CAALFM_C206220CA Putative DNA damage and meiotic pachytene checkpoint protein; increased transcription is observed upon benomyl treatment CAALFM_C206230WA Putative endoribonuclease; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C206240WA Putative Core Sm protein; Hap43p-induced gene; flucytosine induced CAALFM_C206250CA Putative hexameric MCM complex subunit; predicted role in control of cell division; periodic mRNA expression. peak at cell-cycle M/G1 phase; regulated by tyrosol, cell density, Plc1; repressed by alpha pheromone in SpiderM medium CAALFM_C206260WA Ortholog(s) have mitochondrial inner membrane, mitochondrial large ribosomal subunit localization CAALFM_C206270WA Ortholog of C. dubliniensis CD36 : Cd36_20660, C. parapsilosis CDC317 : CPAR2_104730, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133951 and Debaryomyces hansenii CBS767 : DEHA2F02068g CAALFM_C206280CA Ortholog of C. dubliniensis CD36 : Cd36_20670, C. parapsilosis CDC317 : CPAR2_104720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103989 and Debaryomyces hansenii CBS767 : DEHA2F02046g CAALFM_C206290CA Putative mitochondrial F1F0 ATP synthase subunit; macrophage/pseudohyphal-induced CAALFM_C206300WA Ortholog(s) have mRNA binding, pre-mRNA 5'-splice site binding activity, role in mRNA 5'-splice site recognition and U1 snRNP, U2-type prespliceosome, commitment complex localization CAALFM_C206310CA Small RAN G-protein; essential; no prenylation predicted; can rescue S. cerevisiae gsp1 viability; macrophage/pseudohyphal-induced; transcript not regulated by white-opaque, yeast-hypha switching; GlcNAc-induced; Spider biofilm repressed CAALFM_C206320WA Putative RNA-binding protein; induced by alpha pheromone in SpiderM medium CAALFM_C206330CA Putative vacuolar transporter; promoter bound by a1p and alpha2p by ChIP-chip analysis CAALFM_C206340WA APSES transcription factor; homodimer; minor role in transcriptional regulation vs Efg1; regulates filamentous growth, phenotypic switch; EFG1 and EFH1 genetically interact; expression interferes with mouse intestinal tract colonization CAALFM_C206350CA Ortholog(s) have 4-hydroxyphenylpyruvate dioxygenase activity and role in aromatic amino acid family biosynthetic process CAALFM_C206360CA Putative constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins; Spider biofilm induced CAALFM_C206370CA Putative cortical actin cytoskeleton protein; constitutive expression independent of MTL or white-opaque status CAALFM_C206390CA Inosine monophosphate (IMP) dehydrogenase; enzyme of GMP biosynthesis; target of mycophenolic acid and mizoribine monophosphate; antigenic during infection; repressed in core stress response; snoRNA snR54 encoded within IMH3 intron CAALFM_C206420CA Putative serine/threonine-protein phosphatase B-type regulatory subunit; transcription is regulated upon yeast-hyphal switch CAALFM_C206430CA Ortholog(s) have role in ethanol metabolic process and mitochondrial inner membrane localization CAALFM_C206440CA Protein with homology to peroxisomal membrane proteins; Sef1p-, Sfu1p-, and Hap43p-regulated gene CAALFM_C206460WA Similar to S. cerevisiae Rta1 (role in 7-aminocholesterol resistance) and Rsb1 (flippase); putative drug-responsive regulatory site; induced by fluphenazine, estradiol, ketoconazole, caspofungin; rat catheter biofilm induced CAALFM_C206470WA Flippase involved in sphingolipid long chain base release; mediates calcineurin-dependent ER stress response and resistance to azoles; Plc1p, Ca2+, calcineurin-regulated CAALFM_C206480WA Ortholog(s) have tRNA (guanine(9)-N(1))-methyltransferase activity, role in tRNA N1-guanine methylation and cytoplasm, nucleolus localization CAALFM_C206490WA Putative peptide N-glycanase; induced by nitric oxide independent of Yhb1p CAALFM_C206510WA Ortholog of C. dubliniensis CD36 : Cd36_20860, C. parapsilosis CDC317 : CPAR2_104250, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115100 and Debaryomyces hansenii CBS767 : DEHA2E10450g CAALFM_C206520CA Putative thiamine transmembrane transporter; Spider biofilm induced CAALFM_C206530WA Ortholog of S. cerevisiae Tah11, a DNA replication licensing factor required for pre-replication complex assembly; rat catheter, flow model and Spider biofilm induced CAALFM_C206540CA P-type calcium-transporting ATPase, involved in control of calcium homeostasis, response to ER stress, hyphal growth, biofilm formation and virulence CAALFM_C206550WA Ortholog of C. parapsilosis CDC317 : CPAR2_201960, C. dubliniensis CD36 : Cd36_20900, Candida tropicalis MYA-3404 : CTRG_04756 and Candida albicans WO-1 : CAWG_04394 CAALFM_C206570CA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on transcription data; similar to orf19.7550 CAALFM_C206590CA Glycerophosphoinositol permease; involved in utilization of glycerophosphoinositol as a phosphate source; Rim101-repressed; virulence-group-correlated expression CAALFM_C206600WA Predicted kinase; rat catheter, flow model, Spider biofilm induced CAALFM_C206610CA Protein of unknown function CAALFM_C206620WA Component of the conserved oligomeric Golgi complex; predicted to mediate fusion of transport vesicles to Golgi compartments; clade-associated gene expression CAALFM_C206630CA Ortholog of C. parapsilosis CDC317 : CPAR2_104640 and Candida orthopsilosis Co 90-125 : CORT_0B05695 CAALFM_C206640CA Putative tRNA-Val synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C206650CA Ortholog(s) have role in spliceosomal snRNP assembly and U4/U6 x U5 tri-snRNP complex, mitochondrion localization CAALFM_C206660WA Ortholog(s) have role in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C206670CA Essential serine/threonine protein kinase involved in mitotic spindle formation and cytokinesis; required for septum formation, exit from mitosis, and normal hyphal morphogenesis; virulence-group-correlated expression CAALFM_C206680WA Putative ammonium transporter; upregulated in the presence of human neutrophils; fluconazole-downregulated; repressed by nitric oxide; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C206690CA Putative peroxin CAALFM_C206700WA Protein similar to A. niger predicted peroxisomal copper amino oxidase; mutation confers hypersensitivity to toxic ergosterol analog; F-12/CO2 early biofilm induced CAALFM_C206710WA Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process CAALFM_C206720WA Putative reductase; Nrg1 and Tup1-regulated; benomyl- and hyphal-induced; macrophage/pseudohyphal-repressed; repressed by low iron; possibly involved in osmotic stress response; stationary phase enriched protein; Spider biofilm induced CAALFM_C206730WA Eisosome component with a predicted role in endocytosis; protein present in exponential and stationary growth phase yeast cultures; caspofungin repressed; biofilm induced; fungal-specific (no human/murine homolog); sumoylation target CAALFM_C206740WA Protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C206750CA Ortholog of C. dubliniensis CD36 : Cd36_21050, C. parapsilosis CDC317 : CPAR2_104310, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104515 and Debaryomyces hansenii CBS767 : DEHA2F01650g CAALFM_C206760CA Protein of unknown function; flow model biofilm induced; nitric oxide-repressed CAALFM_C206770WA Ortholog(s) have actin filament binding, actin monomer binding activity and role in actin cortical patch organization, actin filament depolymerization, actin filament severing, sequestering of actin monomers CAALFM_C206780CA Ortholog(s) have ubiquitin-protein transferase activity, role in protein ubiquitination, response to ethanol, septin ring assembly and cytoplasm, nucleus localization CAALFM_C206790WA Putative pre-mRNA-splicing factor; decreased transcription is observed upon benomyl treatment CAALFM_C206800CA Protein of unknown function; Spider biofilm induced CAALFM_C206810CA Ribosomal protein; repressed by phagocytosis; colony morphology-related gene regulation by Ssn6; Hap43-induced; Spider biofilm repressed CAALFM_C206820CA Putative proteasome beta-5 subunit; macrophage-induced protein CAALFM_C206830CA Fork-head transcription factor; forms a heterodimer with Ifh1 that is tethered to promoters by Tbf1; positively regulates rRNA and ribosomal protein gene transcription CAALFM_C206840WA Putative GPI-anchored protein; similar but not orthologous to S. cerevisiae Spr1, a sporulation-specific exo-1,3-beta-glucanase; mutant is viable CAALFM_C206850WA Ortholog of Slx9 required for pre-rRNA processing; associated with 90S pre-ribosome and 43S small ribosomal subunit precursor, interacts with U3 snoRNA in S. cerevisiae; gene has intron; Spider biofilm induced CAALFM_C206860WA Protein similar to GDP/GTP exchange factors; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed CAALFM_C206870CA Putative 1,4-benzoquinone reductase; hyphal-induced; regulated by Cyr1, Ras1, Efg1, Nrg1, Rfg1, Tup1; Hap43-induced; Spider biofilm induced CAALFM_C206880CA Endoprotease B; regulated by heat, carbon source (GlcNAc-induced), nitrogen, macrophage response, human neutrophils; similar to (does not replace) S. cerevisiae vacuolar B protease Prb1p; flow model biofilm induced; Spider biofilm induced CAALFM_C206890CA Similar to oxidoreductases and to S. cerevisiae Yjr096wp; Sfu1 repressed; induced by benomyl treatment, Ssr1; Hap43-repressed; flow model biofilm repressed CAALFM_C206910WA Vacuolar Rab small monomeric GTPase involved in vacuolar biogenesis; involved in filamentous growth and virulence CAALFM_C206920CA Ortholog(s) have cytosol, nucleus localization CAALFM_C206930CA Ortholog of C. parapsilosis CDC317 : CPAR2_406700, C. dubliniensis CD36 : Cd36_21220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_127772 and Candida orthopsilosis Co 90-125 : CORT_0C06120 CAALFM_C206940CA Acyl CoA:sterol acyltransferase; uses cholesterol and oleoyl-CoA substrates; protoberberine derivative drug inhibits enzyme activity; ketoconazole-induced; Hap43-repressed; flow model biofilm induced; Spider biofilm induced CAALFM_C206950CA Putative metalloprotease of the mitochondrial inner membrane; expression downregulated in an ssr1 null mutant CAALFM_C206960WA Putative spermidine synthase; predicted role in pantothenate and spermidine biosynthesis; Spider biofilm repressed CAALFM_C206970WA Adenine deaminase; purine salvage and nitrogen catabolism; colony morphology-related regulation by Ssn6; Hog1, CO2-induced; chlamydospore formation repressed in C. albicans and C. dubliniensis; rat catheter and F-12/CO2 biofilm induced CAALFM_C206980WA Protein of unknown function; rat catheter biofilm repressed CAALFM_C206990WA Protein of unknown function; expression regulated by white-opaque switch; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C207000WA Ortholog(s) have cytosol, nucleus localization CAALFM_C207010WA Predicted ER protein involved in ER-nucleus signaling; Spider biofilm repressed CAALFM_C207020CA Ortholog of C. dubliniensis CD36 : Cd36_21310, C. parapsilosis CDC317 : CPAR2_406650, Candida tenuis NRRL Y-1498 : CANTEDRAFT_130046 and Debaryomyces hansenii CBS767 : DEHA2F24134g CAALFM_C207030CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C207040WA Putative transcription factor with zinc finger DNA-binding motif CAALFM_C207060WA Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U2 snRNP, U2-type prespliceosome localization CAALFM_C207070WA Protein similar to quinone oxidoreductases; induced by benomyl treatment, nitric oxide; oxidative stress-induced via Cap1; stationary-phase enriched protein; Spider biofilm induced CAALFM_C207080CA Ortholog of C. dubliniensis CD36 : Cd36_21360, C. parapsilosis CDC317 : CPAR2_406560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103408 and Debaryomyces hansenii CBS767 : DEHA2F24024g CAALFM_C207090CA Protein with similarity to fatty acid desaturase (stearoyl-CoA desaturase); homozygous null mutant shows decreased production of prostaglandin E2 CAALFM_C207100WA Ortholog(s) have DNA translocase activity, role in positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation and SWI/SNF complex, cytosol localization CAALFM_C207110CA Ortholog(s) have ATPase activity, DNA binding, nucleosome binding activity and Isw1a complex localization CAALFM_C207120WA Putative DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density CAALFM_C207130CA Predicted MAP kinase-activated protein kinase, similar to S. cerevisiae serine/threonine protein kinase Rck2p; induced by osmotic stress via Hog1p; macrophage/pseudohyphal-repressed; mutants are sensitive to rapamycin CAALFM_C207140WA Putative 3-phosphoserine phosphatase; induced by benomyl or in azole-resistant strain that overexpresses MDR1; early-stage flow model biofilm induced; Spider biofilm repressed CAALFM_C207160WA Ortholog of S. cerevisiae Smf1; manganese transporter; Gcn4-regulated; Hap43, alkaline induced; caspofungin repressed; mutants are viable CAALFM_C207170CA Putative Aft domain transcription factor; role in regulation of iron metabolism, oxidative stress, adhesion, hyphal growth, colony morphology, virulence; complements S. cerevisiae aft1 mutation; Spider biofilm induced CAALFM_C207180WA Ortholog of C. dubliniensis CD36 : Cd36_21450, Candida tropicalis MYA-3404 : CTRG_01739 and Candida albicans WO-1 : CAWG_05814 CAALFM_C207190CA Putative mitochondrial ribosomal protein; predicted role in aerobic respiration; Spider biofilm repressed CAALFM_C207200WA Ortholog(s) have DNA-directed RNA polymerase activity, RNA-directed RNA polymerase activity CAALFM_C207210CA cAMP-dependent protein kinase catalytic subunit; isoform of Tpk1; needed for epithelial cell damage, engulfment and oral (not systemic) virulence in mice; control of morphogenesis and stress response; rat catheter, Spider biofilm repressed CAALFM_C207220WA Putative 20S proteasome assembly protein; filament induced; induced by alpha pheromone in SpiderM medium CAALFM_C207230CA Putative transcription factor with zinc cluster DNA-binding motif CAALFM_C207240CA Ortholog(s) have mitochondrion localization CAALFM_C207250CA Has domain(s) with predicted catalytic activity, catechol 1,2-dioxygenase activity, ferric iron binding, iron ion binding and oxidoreductase activity, more CAALFM_C207260CA Putative 3-dehydroquinate dehydratase; ketoconazole-repressed; protein abundance downregulated by macrophages; flow model biofilm induced CAALFM_C207270WA Protein with an FMN-binding domain; Hap43-repressed; flow model biofilm induced CAALFM_C207280WA Protein of unknown function; transcription induced by benomyl treatment CAALFM_C207290WA Putative deoxyhypusine hydroxylase; ketoconazole-induced; protein level decreases in stationary phase cultures; required for biofilm formation; Spider biofilm repressed CAALFM_C207300CA Putative DNA-directed RNA polymerase I; induced upon adherence to polystyrene CAALFM_C207310WA T-complex protein 1, epsilon subunit; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C207320WA Protein with Myo5p-dependent localization to cortical actin patches at hyphal tip; mutation confers hypersensitivity to cytochalasin D; Spider biofilm repressed CAALFM_C207330WA Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; involved in regulation of ribosome biogenesis, starvation response, and adhesion CAALFM_C207340WA Putative nucleolar protein; Hap43-induced; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Spider biofilm induced CAALFM_C207350WA Putative DNA replication protein; periodic mRNA expression, peak at cell-cycle M/G1 phase; Spider biofilm induced CAALFM_C207360WA Ortholog(s) have RNA methyltransferase activity, role in 7-methylguanosine cap hypermethylation, meiotic nuclear division, nucleologenesis, regulation of telomere maintenance via telomerase and nucleolus localization CAALFM_C207370WA Ortholog of C. dubliniensis CD36 : Cd36_21640, C. parapsilosis CDC317 : CPAR2_105040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112352 and Debaryomyces hansenii CBS767 : DEHA2C08008g CAALFM_C207380WA Heat shock protein; at yeast-form cell surface, not hyphae; antigenic; Gcn4-regulated; induced by amino acid starvation (3-AT) or by adherence to polystyrene; macrophage-repressed; sumoylation target; possibly essential CAALFM_C207390CA Protein of unknown function; Spider biofilm repressed CAALFM_C207400CA Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced CAALFM_C207410WA Ortholog(s) have role in medium-chain fatty acid biosynthetic process CAALFM_C207420WA Putative phosphoglycerate mutase family protein; stationary phase enriched protein; early-stage flow model biofilm induced; Spider biofilm repressed CAALFM_C207430CA Putative nicotinamide riboside hydrolase; cleaves N-glycosidic bonds in nucleosides; pyrimidine salvage and nicotinamide riboside salvage pathways; Spider biofilm induced CAALFM_C207440CA Ortholog(s) have sterol esterase activity, role in sterol metabolic process and integral component of membrane, lipid particle localization CAALFM_C207450CA Putative U3-containing 90S preribosome processome complex subunit; Hap43-induced; essential; S. cerevisiae ortholog is essential; represses in core stress response CAALFM_C207460WA Putative TFIID subunit; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_C207470WA Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression CAALFM_C207480WA Lysophospholipid acyltransferase, involved in phospholipid remodeling; role in glycerophospholipid biosynthesis; rat catheter biofilm repressed CAALFM_C207490WA Putative ferrochelatase involved in heme biosynthesis; transcript not regulated by iron levels and not affected by a yfh1 null mutation; Spider biofilm repressed CAALFM_C207500CA RNA polymerase II core mediator complex subunit CAALFM_C207510WA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C207520CA Ortholog(s) have mRNA binding activity, role in mRNA splice site selection, positive regulation of mRNA splicing, via spliceosome and U1 snRNP, U2-type prespliceosome, commitment complex, cytoplasm localization CAALFM_C207530CA Ortholog(s) have protein serine/threonine kinase activity, role in meiotic recombination checkpoint, protein phosphorylation, reciprocal meiotic recombination, regulation of linear element assembly and cytosol, linear element localization CAALFM_C207540WA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide CAALFM_C207550WA Plasma membrane protein; repressed by nitric oxide CAALFM_C207560WA Component of the SWR1 complex, which has a role in exchanging histone variant H2AZ for histone H2A in chromatin; required for proper nucleosome positioning on WOR1 promoter CAALFM_C207570WA Putative ribonucleoside diphosphate reductase;colony morphology-related gene regulation by Ssn6; transcript regulated by tyrosol and cell density; Hap43-repressed; Spider biofilm induced CAALFM_C207580WA Putative malate permease; induced during macrophage infection; regulated by Gcn2 and Gcn4; putative peroxisome targeting signal; Hap43-repressed; Spider biofilm induced CAALFM_C207590WA Subunit G of the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase); involved in vacuolar acidification; rat catheter biofilm repressed CAALFM_C207600CA S. cerevisiae ortholog Mcs7 has a role in reciprocal meiotic recombination; Spider biofilm repressed CAALFM_C207610CA Ortholog(s) have role in ribosome-associated ubiquitin-dependent protein catabolic process and RQC complex, cytosol, cytosolic large ribosomal subunit localization CAALFM_C207620WA Has domain(s) with predicted Rho guanyl-nucleotide exchange factor activity, role in regulation of Rho protein signal transduction and intracellular localization CAALFM_C207630CA Possible stress protein; increased transcription associated with CDR1 and CDR2 overexpression or fluphenazine treatment; regulated by Sfu1, Nrg1, Tup1; stationary phase enriched protein; Spider biofilm induced CAALFM_C207640WA BAR domain-containing protein, forms heterodimer with Rvs162p that binds liposomes in vitro; flow model biofilm induced CAALFM_C207650CA Ortholog(s) have extracellular region localization CAALFM_C207660WA Putative protein with a predicted role in establishment and maintenance of sister chromatid condensation and cohesion; cell-cycle regulated periodic mRNA expression CAALFM_C207670CA Putative nucleoporin; moderately induced at 42 degrees C CAALFM_C207680WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C207690WA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C207700CA Ortholog of C. dubliniensis CD36 : Cd36_21980, Debaryomyces hansenii CBS767 : DEHA2F19734g, Pichia stipitis Pignal : psti_CGOB_00208 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00029 CAALFM_C207710WA Ortholog of C. dubliniensis CD36 : Cd36_21990, C. parapsilosis CDC317 : CPAR2_103660, Debaryomyces hansenii CBS767 : DEHA2F19756g and Pichia stipitis Pignal : PICST_61375 CAALFM_C207720CA Protein of unknown function; Spider biofilm induced CAALFM_C207730WA Putative vacuolar cation channel shock; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed CAALFM_C207740WA Ortholog(s) have role in response to salt stress and cytoplasm localization CAALFM_C207750WA Ortholog(s) have GTPase activity CAALFM_C207760WA Predicted membrane protein of unknown function; Spider biofilm induced CAALFM_C207770CA Ortholog of C. parapsilosis CDC317 : CPAR2_103590, Debaryomyces hansenii CBS767 : DEHA2C08118g, Pichia stipitis Pignal : psti_CGOB_00124 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_49916 CAALFM_C207790CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C207800WA Ortholog(s) have ribosome binding activity, role in mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation and Cbp3p-Cbp6 complex, mitochondrial ribosome localization CAALFM_C207810WA Protein of unknown function; rat catheter biofilm repressed CAALFM_C207820CA Putative endoplasmic reticulum protein; possibly adherence-induced CAALFM_C207830WA Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc3p CAALFM_C207840WA Has domain(s) with predicted N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding activity and role in oxidation-reduction process CAALFM_C207860WA Ortholog(s) have ubiquitin binding activity and cytoplasm localization CAALFM_C207870CA Ortholog of Candida albicans WO-1 : CAWG_05881 CAALFM_C207880WA Cargo-binding subunit of the clathrin associated protein complex (AP-2), involved in endocytosis CAALFM_C207890WA Putative 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; Hap43-induced; repressed during core stress response CAALFM_C207900WA Putative NAD-specific glutamate dehydrogenase; fungal-specific; transcript regulated by Nrg1, Mig1, Tup1, and Gcn4; stationary phase enriched protein; flow model biofilm induced; Spider biofilm induced CAALFM_C207910CA Ortholog of C. dubliniensis CD36 : Cd36_11730, C. parapsilosis CDC317 : CPAR2_104195, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109454 and Debaryomyces hansenii CBS767 : DEHA2C10076g CAALFM_C207920WA Ortholog(s) have diphthine methylesterase activity, role in endocytic recycling, peptidyl-diphthamide biosynthetic process from peptidyl-histidine and endosome localization CAALFM_C207930CA Verprolin-related protein involved in actin cytoskeleton organization and polarized morphogenesis; interacts with Wal1p and Myo5p; downregulated upon adherence to polystyrene CAALFM_C207940CA Protein involved in cell wall mannan biosynthesis; mutation confers hypersensitivity to tunicamycin; transcript elevated in chk1, nik1, and sln1 homozygous null mutants; possibly essential gene, disruptants not obtained by UAU1 method CAALFM_C207950WA Ortholog(s) have role in positive regulation of TORC1 signaling and Seh1-associated complex, cytosol, extrinsic component of fungal-type vacuolar membrane, nuclear periphery, nuclear pore outer ring localization CAALFM_C207960CA Putative 66S pre-ribosomal particles conmponent; Hap43-induced; repressed by prostaglandins CAALFM_C207980WA Putative fumarylacetoacetate hydrolase; clade-associated gene expression; rat catheter and Spider biofilm repressed CAALFM_C208000CA YEF3-subfamily ABC family protein; predicted not to be a transporter; repressed in core stress response; mutation confers hypersensitivity to amphotericin B CAALFM_C208010WA Putative proteasome activator; binds core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; ortholog of S. cerevisiae Blm10; transcript regulated by Nrg1 and Mig1 CAALFM_C208020CA Ortholog(s) have calcium ion binding, zinc ion binding activity, role in axial cellular bud site selection, bipolar cellular bud site selection, regulation of COPII vesicle coating and cellular bud neck, cytosol, nucleus localization CAALFM_C208030WA Ortholog of Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00067 and Candida albicans WO-1 : CAWG_05895 CAALFM_C208040CA Ribosomal protein S10; downregulated in the presence of human whole blood or PMNs; Spider biofilm repressed CAALFM_C208050CA Transporter of ferrichrome siderophores, not ferrioxamine B; required for human epithelial cell invasion in vitro, not for mouse systemic infection; regulated by iron, Sfu1, Rfg1, Tup1, Hap43; rat catheter and Spider biofilm induced CAALFM_C208060WA Protein of unknown function; Spider biofilm induced CAALFM_C208070CA Mitochondrial carrier family member, involved in iron homeostasis; putative membrane transporter localized to the mitochondrial membrane; transcription under control of Atf2p; regulated by Sef1p, Sfu1p, and Hap43p CAALFM_C208080CA Protein with a 2-hydroxyacid dehydrogenase catalytic domain; Hap43-repressed; Plc1-regulated; overlaps orf19.2177 CAALFM_C208090WA Sef1p-, Sfu1p-, and Hap43p-regulated gene; overlaps IFM3/orf19.2176 CAALFM_C208100WA Putative mitochondrial cell death effector; induced by nitric oxide; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C208110WA Putative DNA recombination and repair protein; induced by interaction with macrophage; transcript is regulated by Nrg1, Mig1, and Tup1; essential protein; S. cerevisiae ortholog is essential CAALFM_C208120WA Putative negative regulator of RNA polymerase III; decreased expression in hyphae vs yeast cells; caspofungin repressed; Spider biofilm repressed CAALFM_C208130WA D-Arabinose dehydrogenase; dehydro-D-arabinono-1,4-lactone synthesis; active on D-arabinose, L-fucose, L-xylose, L-galactose; inhibited by metal ions, thiol group-specific reagents; induced on polystyrene adherence; Spider biofilm induced CAALFM_C208140CA Putative transporter; fungal-specific; Hog1-repressed; repressed by 17-beta-estradiol, ethynyl estradiol; Hap43-induced; Spider biofilm induced CAALFM_C208150WA Ortholog of C. parapsilosis CDC317 : CPAR2_805720, C. dubliniensis CD36 : Cd36_22330, Lodderomyces elongisporus NRLL YB-4239 : LELG_02628 and Candida orthopsilosis Co 90-125 : CORT_0C03440 CAALFM_C208160CA Ortholog(s) have role in cellular protein localization, endoplasmic reticulum inheritance, endoplasmic reticulum tubular network organization, nuclear pore complex assembly, vesicle-mediated transport CAALFM_C208170WA Putative sterol deacetylase; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C208180CA Ortholog(s) have role in ribosomal large subunit biogenesis, ribosomal small subunit biogenesis and cytosolic large ribosomal subunit, nucleolus localization CAALFM_C208190WA Putative vacuolar H(+)-ATPase; plasma membrane localized; rat catheter biofilm repressed CAALFM_C208200WA Predicted hydrolase; induced by nitric oxide CAALFM_C208210CA a-factor mating pheromone; produced in opaque MTLa cells; required for mating competence of MTLa cells, but not MTLalpha; induced by alpha-factor CAALFM_C208240WA Predicted ORF in retrotransposon Tca3; similar to Gag-Pol; a-specific transcript, alpha-factor induced; rat catheter biofilm repressed; mRNA binds She3 CAALFM_C208260WA Protein of unknown function; Hap43-repressed gene; by Rgt1; repressed in Spider biofilms by Bcr1, Tec1, Brg1, Rob1 and induced by Efg1, Ndt80; Spider biofilm induced CAALFM_C208270CA Putative casein kinase; plasma membrane-localized CAALFM_C208280WA Subunit of the NuA4 histone acetyltransferase complex; rat catheter and Spider biofilm induced CAALFM_C208290CA Upregulated by cAMP in filamentous growth; induced in high iron, decreased upon yeast-hypha switch; downregulation correlates with clinical fluconazole resistance; Ras1-regulated; Hap43-repressed; flow model biofilm induced CAALFM_C208310WA Mitochondrial inner membrane protein; predicted role in protein import; Hap43-repressed gene; flow model biofilm induced; Spider biofilm repressed CAALFM_C208320CA Ortholog of C. parapsilosis CDC317 : CPAR2_407000, C. dubliniensis CD36 : Cd36_22440, Candida tenuis NRRL Y-1498 : cten_CGOB_00049 and Lodderomyces elongisporus NRLL YB-4239 : LELG_02401 CAALFM_C208330WA Protein with a thioredoxin domain; predicted role in cell redox homeostasis; rat catheter and Spider biofilm induced CAALFM_C208340CA Ortholog of C. dubliniensis CD36 : Cd36_22470, Candida tropicalis MYA-3404 : CTRG_01829 and Candida albicans WO-1 : CAWG_05920 CAALFM_C208350CA Ortholog of C. dubliniensis CD36 : Cd36_22500, Candida tropicalis MYA-3404 : CTRG_01825 and Candida albicans WO-1 : CAWG_05921 CAALFM_C208360CA Oligopeptide transporter; fungal-specific (no human or murine homolog); induced by BSA, but not by tetrapeptide or pentapeptide CAALFM_C208370CA Translation elongation factor 1-alpha; at cell surface; binds human plasminogen; macrophage/pseudohyphal-induced; induced in RHE model of oral candidiasis, in clinical oral candidiasis isolates; possibly essential; Spider biofilm repressed CAALFM_C208380CA Ortholog(s) have protein complex scaffold, protein kinase activator activity CAALFM_C208390WA Protein of unknown function; Hap43-repressed; colony morphology-related gene regulation by Ssn6; Spider biofilm induced CAALFM_C208400CA Ortholog of C. dubliniensis CD36 : Cd36_22550, Candida tropicalis MYA-3404 : CTRG_01836 and Candida albicans WO-1 : CAWG_01505 CAALFM_C208420WA Ortholog(s) have DNA-3-methyladenine glycosylase activity, damaged DNA binding activity and role in DNA dealkylation involved in DNA repair, base-excision repair, AP site formation CAALFM_C208430CA Putative GPI-anchored protein; secreted; fluconazole-induced CAALFM_C208450WA Ortholog of C. dubliniensis CD36 : Cd36_22580, C. parapsilosis CDC317 : CPAR2_406960, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113677 and Debaryomyces hansenii CBS767 : DEHA2D03608g CAALFM_C208460CA Ortholog(s) have role in purine nucleobase catabolic process and cytosol, nucleus localization CAALFM_C208470CA Protein involved in telomere maintenance; forms a complex with Ten1p CAALFM_C208480WA Ribosomal protein; Hap43-induced; F-12/CO2 early biofilm and rat catheter biofilm induced CAALFM_C208490WA Essential cell wall protein involved in cell wall integrity and rigidity; periodic mRNA expression peaks at M/G1 phase; Ace2p-induced; required for virulence in a mouse model of infection CAALFM_C208500WA Putative NEDD4 family E3 ubiquitin ligase; induced during infection of murine kidney, compared to growth in vitro; has murine homolog; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C208510WA Ortholog of C. dubliniensis CD36 : Cd36_22640, C. parapsilosis CDC317 : CPAR2_406910, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104937 and Debaryomyces hansenii CBS767 : DEHA2D02706g CAALFM_C208520CA Ortholog of C. parapsilosis CDC317 : CPAR2_406905, Candida orthopsilosis Co 90-125 : CORT_0C06265 and Candida tropicalis MYA-3404 : CTRG_05051 CAALFM_C208530CA Ortholog(s) have cytosol, nucleus localization CAALFM_C208540CA Has domain(s) with predicted zinc ion binding activity CAALFM_C208550CA Ortholog(s) have exoribonuclease II activity, role in mitochondrial RNA catabolic process and mitochondrial degradosome localization CAALFM_C208560WA Protein similar to S. cerevisiae Smc2p, which is a component of the condensin complex involved in mitotic chromosome condensation; induced under hydroxyurea treatment CAALFM_C208570WA Putative mannosyltransferase of Golgi; member of Mnn9p family; similar to S. cerevisiae Anp1p; fungal-specific (no human or murine homolog) CAALFM_C208580WA Possible pseudogene; similar to Ywp1p; ORF extended upstream from the initiating Met of orf19.3621 has a stop codon in the region corresponding to the Ywp1p signal peptide; disruption causes no apparent phenotype; no expression detected CAALFM_C208590WA Secreted yeast wall protein; possible role in dispersal in host; mutation increases adhesion and biofilm formation; propeptide; growth phase, phosphate, Ssk1/Ssn6/Efg1/Efh1/Hap43 regulated; mRNA binds She3; flow and Spider biofilm repressed CAALFM_C208600WA Putative GTP-binding protein; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; (see Locus History Note for Assembly 19 correction) CAALFM_C208610WA Putative farnesyl-diphosphate farnesyl transferase (squalene synthase); sterol biosynthesis pathway; likely essential for growth; regulated by fluconazole, lovastatin; amphotericin B, caspofungin repressed; Spider biofilm repressed CAALFM_C208620WA Protein of unknown function; induced in core caspofungin response; expression upregulated in an ssr1 null mutant; induced by nitric oxide independent of Yhb1p CAALFM_C208630CA Ortholog(s) have RNA polymerase II C-terminal domain phosphoserine binding, RNA polymerase II core binding, chromatin binding and transcription factor activity, more CAALFM_C208640CA Putative NADH:quinone oxidoreductase; similar to 1,4-benzoquinone reductase; immunogenic in mice; induced by benomyl, oxidative stress via Cap1; fungal-specific; farnesol-repressed; Spider biofilm induced CAALFM_C208650WA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide CAALFM_C208660CA Protein of unknown function; upregulation correlates with clinical development of fluconazole resistance; regulated by Sef1, Sfu1, and Hap43 CAALFM_C208670CA Small subunit (SSU) processome component; mutation confers resistance to 5-fluorocytosine (5-FC); physically interacts with TAP-tagged Nop1p CAALFM_C208680WA Mismatch repair protein; predicted role in repair of insertion or deletion mutations and removal of nonhomologous DNA ends; rat catheter biofilm repressed CAALFM_C208690CA Ortholog of C. dubliniensis CD36 : Cd36_22860, C. parapsilosis CDC317 : CPAR2_806540, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108823 and Debaryomyces hansenii CBS767 : DEHA2B13596g CAALFM_C208700CA Ortholog of S. cereviae Sna4 vacuolar outer membrane protein that plays a role in sensitivity to NA+; induced by Mnl1 under weak acid stress CAALFM_C208710WA Putative peroxin CAALFM_C208720WA Ortholog(s) have Ino80 complex localization CAALFM_C208730WA Regulator of filamentous growth; required for biofilm formation, virulence; interacts with Flo8 and Mss11 CAALFM_C208740WA Has domain(s) with predicted ATP binding, nucleoside-triphosphatase activity, nucleotide binding activity CAALFM_C208750WA Protein of unknown function; flow model biofilm induced CAALFM_C208760CA Putative translation initiation factor eIF4G; overexpression causes hyperfilamentation; hyphal- and macrophage-induced; genes encoding some translation factors are downregulated upon phagocytosis by murine macrophage CAALFM_C208770CA Putative adhesin-like protein; predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome CAALFM_C208780WA Putative ATPase of the 19S regulatory particle of the 26S proteasome; transcript regulated by Mig1; regulated by Gcn2 and Gcn4 CAALFM_C208790WA Functional homolog of S. cerevisiae Jem1p, which acts with Scj1p and Kar2p (BiP) in protein folding and ER-associated degradation of misfolded proteins, and also has a role in karyogamy; has J domain and 4 tetratricopeptide repeats CAALFM_C208800CA Putative vacuolar aminopeptidase Y,; regulated by Gcn2 and Gcn4; rat catheter and Spider biofilm repressed CAALFM_C208810CA Putative inorganic pyrophosphatase; antigenic; soluble protein in hyphae; macrophage-induced protein; protein present in exponential and stationary phase yeast; possibly essential (UAU1 method); sumoylation target; Spider biofilm repressed CAALFM_C208820CA DNA endonuclease; required for genetic recombination between homologous chromosomes during the parasexual cycle; produced in mitotically dividing cells; similar to S. cerevisiae Spo11 which functions in recombination during meiosis CAALFM_C208830WA Ortholog(s) have role in fungal-type cell wall organization, vesicle-mediated transport and integral component of endoplasmic reticulum membrane localization CAALFM_C208840WA Putative tRNA methyltransferase complex subunit; regulated by Gcn4; repressed in response to amino acid starvation (3-aminotriazole treatment); Spider biofilm induced CAALFM_C208850CA Predicted 2-hydroxyacid dehydrogenase; Hap43-repressed gene CAALFM_C208860WA Putative serine/threonine protein kinase; Hap43-repressed; induced by prostaglandins; possibly an essential gene, disruptants not obtained by UAU1 method; flow model biofilm induced; Spider biofilm induced CAALFM_C208870CA 1,3-beta-glucan-linked cell wall protein; N-mannosylated, O-glycosylated by Pmt1; cell wall defect in het mutant; Hog1/fluconazole/hypoxia induced; iron/Efg1/Plc1/temp regulated; flow model biofilm induced; hyphal, Spider biofilm repressed CAALFM_C208880WA Protein similar to S. cerevisiae Bud20p, which affects bud site selection; transposon mutation affects filamentous growth CAALFM_C208890WA Ortholog(s) have sequence-specific DNA binding activity CAALFM_C208900WA Ortholog of C. parapsilosis CDC317 : CPAR2_806510, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109089, Debaryomyces hansenii CBS767 : DEHA2B13508g and Pichia stipitis Pignal : PICST_59544 CAALFM_C208910CA Protein with a metallo-dependent phosphatase domain; ketoconazole-induced; upregulation correlates with clinical development of fluconazole resistance CAALFM_C208920WA Component of a complex containing the Tor2p kinase; possible a role in regulation of cell growth; Spider biofilm induced CAALFM_C208930WA Ortholog(s) have role in proteasome-mediated ubiquitin-dependent protein catabolic process and CENP-A containing chromatin, nucleus, proteasome regulatory particle, lid subcomplex, proteasome storage granule localization CAALFM_C208940CA ESCRT I protein sorting complex subunit; involved in Rim8 processing and proteolytic activation of Rim101, which regulates pH response; role in echinocandin, azole sensitivity CAALFM_C208950WA Predicted homeodomain-like transcription factor; also has a metal-binding Ada DNA repair protein domain; Spider biofilm induced CAALFM_C208960CA Ortholog(s) have role in barrier septum assembly, positive regulation of GTPase activity, protein localization to bud neck and barrier septum, cell division site, cellular bud neck, cytosol localization CAALFM_C208970CA Ortholog(s) have role in dolichol biosynthetic process, dolichol-linked oligosaccharide biosynthetic process, polyprenol catabolic process, pseudohyphal growth CAALFM_C208980CA GPI-anchored adhesin-like protein; filament induced; regulated by Nrg1, Tup1; regulated upon hyphal formation; mRNA binds to She3 and is localized to yeast-form buds and hyphal tips; induced during chlamydospore formation CAALFM_C208990CA Putative adhesin-like protein CAALFM_C209000CA Ortholog of C. dubliniensis CD36 : Cd36_23180, Candida tropicalis MYA-3404 : CTRG_01968 and Candida albicans WO-1 : CAWG_05983 CAALFM_C209010WA Putative SIN3-binding protein 3 homolog; caspofungin induced; macrophage/pseudohyphal-repressed; rat catheter biofilm induced CAALFM_C209020WA Phosphorylated protein described as having role in control of cell division; RNA abundance regulated by tyrosol and cell density; merged with orf19.201 in Assembly 20; unmerged from orf19.201 in a revision of Assembly 21 CAALFM_C209030WA Protein of unknown function; unmerged from orf19.202 in a revision of Assembly 21 CAALFM_C209040WA Putative nuclear RNA-binding protein; Spider biofilm repressed CAALFM_C209050CA Protein of unknown function; hyphal-induced expression; upregulated in a cyr1 null mutant CAALFM_C209060CA Putative asparagine synthetase; soluble protein in hyphae; regulated by Rim101; decreased expression at pH 4 vs pH 8; protein detected during exponential and stationary phases of yeast-form growth CAALFM_C209070CA Putative glycerol-3-phosphate acyltransferase; Hog1-repressed CAALFM_C209080CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C209100CA Protein of unknown function; flow model biofilm induced CAALFM_C209110CA Protein of unknown function; repressed by alpha pheromone in SpiderM medium CAALFM_C209130CA Putative GPI-anchored adhesin-like protein; opaque-specific transcript; macrophage-induced gene; Hap43-repressed gene; Spider biofilm induced CAALFM_C209140CA Sulfite reductase; role in sulfur amino acid metabolism; induced by human whole blood or PMNs; Hog1-induced; possibly adherence-induced; flow model, Spider model, F-12/CO2 biofilm induced CAALFM_C209150WA Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; sphingolipid biosynthesis; fluconazole, caspofungin induced; macrophage-repressed; Spider biofilm induced CAALFM_C209160WA Ortholog(s) have role in U1 snRNA 3'-end processing, U4 snRNA 3'-end processing and U5 snRNA 3'-end processing, more CAALFM_C209170WA Protein similar to stomatin mechanoreception protein CAALFM_C209180WA Putative ribonuclease H2 subunit; required for RNase H2 activity; repressed in Spider biofilms by Bcr1, Tec1, Brg1, Rob1 CAALFM_C209220WA Immunogenic stress-associated protein; filamentation regulated; induced by benomyl/caspofungin/ketoconazole or in azole-resistant strain; Hog1, farnesol, alkaline repressed; stationary phase enriched; Spider, flow model biofilm induced CAALFM_C209230CA Snf1p complex scaffold protein; similar to S. cerevisiae Gal83p and Sip2p with regions of similarity to Sip1p (ASC and KIS domain); interacts with Snf4p; mutants are hypersensitive to caspofungin and hydrogen peroxide; Hap43p-repressed gene CAALFM_C209240CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C209250WA Ortholog(s) have cytoplasm localization CAALFM_C209260CA Ortholog(s) have hydroxyacylglutathione hydrolase activity, role in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione and cytosol, mitochondrion, nucleus localization CAALFM_C209270CA Putative co-chaperone protein with a predicted role in kinetochore assembly; mutation confers hypersensitivity to radicicol; sumoylation target CAALFM_C209280CA Predicted membrane transporter, member of the fucose:proton symporter (FHS) family, major facilitator superfamily (MFS) CAALFM_C209290WA Ortholog(s) have role in vacuolar proton-transporting V-type ATPase complex assembly and endoplasmic reticulum membrane localization CAALFM_C209300WA RNA polymerase II mediator complex subunit; rat catheter biofilm repressed CAALFM_C209310CA Trimeric GatFAB AmidoTransferase(AdT) complex subunit; involved in the formation of Q-tRNAQ; repressed by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1; Spider biofilm induced CAALFM_C209320CA Pescadillo homolog required for yeast cell growth, lateral yeast growth on filamentous cells and virulence in mice; hyphal cells grow normally in mutant; mutation confers hypersensitivity to 5-fluorocytosine, 5-fluorouracil, tubercidin CAALFM_C209330CA Ortholog of C. dubliniensis CD36 : Cd36_23450, C. parapsilosis CDC317 : CPAR2_407010, Candida tenuis NRRL Y-1498 : cten_CGOB_00249 and Debaryomyces hansenii CBS767 : DEHA2B01980g CAALFM_C209340WA Ortholog of C. parapsilosis CDC317 : CPAR2_407020, C. dubliniensis CD36 : Cd36_23460, Debaryomyces hansenii CBS767 : DEHA2B02002g and Pichia stipitis Pignal : PICST_31649 CAALFM_C209350WA Putative lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; rat catheter biofilm induced CAALFM_C209360WA Ortholog of C. dubliniensis CD36 : Cd36_23480, C. parapsilosis CDC317 : CPAR2_407050, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116822 and Debaryomyces hansenii CBS767 : DEHA2B02046g CAALFM_C209370CA Kinesin-like microtubule motor protein; required for nuclear fusion during mating; C-terminal motor domain; mutants are viable; null has high-frequency white-opaque switching phenotype CAALFM_C209380WA Putative nucleolar protein; constituent of pre-60S ribosomal particles; Hap43-induced; repressed by prostaglandins CAALFM_C209390WA Vacuolar membrane protein; depletion causes abnormal vacuolar morphology, cell separation defect, sensitivity to cell wall stress, increased hyphal branching; essential, no mammalian homolog; Cyr1-regulated; rat catheter biofilm repressed CAALFM_C209400CA C-14 sterol reductase, has a role in ergosterol biosynthesis; mutation confers increased sensitivity to dyclonine; rat catheter and Spider biofilm repressed CAALFM_C209420WA Ortholog of C. dubliniensis CD36 : Cd36_23530, C. parapsilosis CDC317 : CPAR2_406140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116829 and Debaryomyces hansenii CBS767 : DEHA2B01826g CAALFM_C209430WA Ribosomal protein, large subunit; induced by ciclopirox olamine treatment; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed CAALFM_C209460CA Predicted Gal4-like DNA-binding transcription factor; Spider biofilm induced CAALFM_C209470CA Putative DNA mismatch repair factor; ortholog of S. cerevisiae PMS1 which is an ATP-binding protein involved in DNA mismatch repair CAALFM_C209480WA Ortholog(s) have DNA-directed DNA polymerase activity, role in error-free translesion synthesis, error-prone translesion synthesis and mitochondrion, nuclear chromatin, zeta DNA polymerase complex localization CAALFM_C209490WA Putative 4-nitrophenylphosphatase; Hap43p-repressed gene; transcription is regulated upon yeast-hyphal switch CAALFM_C209500WA Predicted tRNA dihydrouridine synthase; Spider biofilm induced CAALFM_C209510CA Ortholog(s) have ATP:ADP antiporter activity, calcium ion binding activity, role in ADP transport, ATP transport, mitochondrial transport and mitochondrion localization CAALFM_C209520CA Chaperonin of the cytosolic TCP1 ring complex; protein present in exponential and stationary-phase yeast cells, but higher amounts in stationary phase; GlcNAc-induced protein CAALFM_C209530WA GPI-anchored cell wall adhesin; Efg1-regulated; mutant suppresses cell adhesion, filamentation, invasive growth defects of S. cerevisiae flo8 or flo11 mutant; biofilm induced; required for biofilm formation; Bcr1-repressed in a/a biofilms CAALFM_C209560CA Ortholog of C. dubliniensis CD36 : Cd36_23640, C. parapsilosis CDC317 : CPAR2_406130, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116273 and Debaryomyces hansenii CBS767 : DEHA2B11176g CAALFM_C209570CA Has domain(s) with predicted heme binding activity CAALFM_C209580WA Ortholog(s) have GTPase activator activity, role in ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport and Golgi apparatus, clathrin-coated vesicle localization CAALFM_C209590CA Ortholog(s) have copper uptake transmembrane transporter activity, inorganic phosphate transmembrane transporter activity CAALFM_C209600CA Putative protein of unknown function; mutant is viable; protein level decreases in stationary phase cultures; Spider biofilm induced CAALFM_C209610WA Ortholog(s) have NAD transporter activity, pyruvate secondary active transmembrane transporter activity, role in NAD transmembrane transport, mitochondrial pyruvate transport and endoplasmic reticulum, mitochondrion localization CAALFM_C209620WA Ortholog(s) have protein disulfide isomerase activity, protein-disulfide reductase (glutathione) activity, unfolded protein binding activity CAALFM_C209630CA Protein with similarity to trimeric LpxA-like enzymes; Hap43-repressed gene CAALFM_C209640WA Phosphomannose isomerase; cell wall biosynthesis enzyme; drug target; functional homolog of S. cerevisiae, E. coli phosphomannose isomerase; Gcn4-regulated; induced on adherence to polystyrene, phagocytosis; 3-AT, Spider biofilm repressed CAALFM_C209650WA Ortholog(s) have poly(A) binding activity, role in mRNA metabolic process and cytoplasm localization CAALFM_C209660WA Putative 66S pre-ribosomal particle component; Hap43-induced; F-12/CO2 early biofilm induced CAALFM_C209670CA Ortholog(s) have 4 iron, 4 sulfur cluster binding, ATPase activity, role in iron-sulfur cluster assembly, tRNA wobble uridine modification and Nbp35-Cfd1 ATPase complex, cytoplasm localization CAALFM_C209680WA Ortholog(s) have SNAP receptor activity and role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER, vesicle fusion CAALFM_C209690CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C209700WA Putative uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; induced by alpha pheromone in SpiderM medium CAALFM_C209710CA Ortholog of S. cerevisiae/S. pombe Lsb5; predicted role in actin cortical patch localization, actin filament organization, endocytosis; flow model biofilm induced; Spider biofilm repressed CAALFM_C209720WA Translation factor eRF3; shows prion-like aggregation in some, not all, studies; partially complements S. cerevisiae sup35 mutant translation defect; species barrier with S. cerevisiae Sup35p prion; gene not regulated by yeast-hyphal switch CAALFM_C209730CA Putative inositol polyphosphate multikinase; moderately induced at 42 deg CAALFM_C209740WA Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane CAALFM_C209750WA Putative alpha-isopropylmalate synthase; fungal-specific; induced by human blood or polymorphonuclear cells; regulated by Gcn2 and Gcn4; stationary phase enriched protein; Spider biofilm induced CAALFM_C209760WA Ortholog of C. dubliniensis CD36 : Cd36_23840, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104074, Debaryomyces hansenii CBS767 : DEHA2B13310g and Pichia stipitis Pignal : PICST_58235 CAALFM_C209770CA Putative phosphatidylinositol-4,5-bisphosphate phosphatase; involved in maintenance of phosphoinositide levels; affects hyphal growth, virulence, cell integrity; interacts with Irs4p CAALFM_C209780CA Protein of unknown function; transcript regulated by Mig1 and Tup1 CAALFM_C209790WA Ortholog of C. dubliniensis CD36 : Cd36_23880, C. parapsilosis CDC317 : CPAR2_806590, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92769 and Debaryomyces hansenii CBS767 : DEHA2B13376g CAALFM_C209800CA Protein of unknown function; expression regulated by white-opaque switch; repressed by alpha pheromone in SpiderM medium CAALFM_C209810CA Protein with predicted peptidase domains; Hap43-repressed gene CAALFM_C209820WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C209830CA Ortholog of C. parapsilosis CDC317 : CPAR2_407330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114646, Debaryomyces hansenii CBS767 : DEHA2B05654g and Pichia stipitis Pignal : PICST_44644 CAALFM_C209840WA Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site CAALFM_C209850CA Has domain(s) with predicted oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors activity CAALFM_C209860CA Putative monooxygenase; mutation confers hypersensitivity to toxic ergosterol analog; constitutive expression independent of MTL or white-opaque status CAALFM_C209870WA Ortholog of S. pombe Stm1 G-protein coupled receptor; PQ-loop domains; constitutive expression independent of MTL or white-opaque status; Hap43-repressed CAALFM_C209880CA Putative protein of unknown function; Plc1-regulated; transcript induced by Mnl1 under weak acid stress; flow model, rat catheter, Spider biofilm induced CAALFM_C209890WA Putative dihydrouridine synthase; Hap43-induced gene; rat catheter biofilm induced; Spider biofilm induced CAALFM_C209900CA Protein involved in mitochondrial matrix protein import CAALFM_C209910CA Putative adhesin-like protein CAALFM_C209920WA Ortholog(s) have role in mitochondrial genome maintenance and mitochondrion localization CAALFM_C209930WA Ortholog(s) have protein complex binding activity and role in ER-associated ubiquitin-dependent protein catabolic process, sporulation resulting in formation of a cellular spore CAALFM_C209940WA bZIP transcription factor; amino acid control response; required for Efg1-dependent pseudohyphal induction by amino acid starvation, not by serum; human whole blood and PMN induced; required for biofilm formation; Spider biofilm induced CAALFM_C209950WA High affinity, high capacity, hypoxanthine-adenine-guanine-cytosine/H+ symporter; similar to S. cerevisiae Fcy2; mutation confers resistance to 5-fluorocytosine (5-FC); flow model biofilm induced CAALFM_C209960WA Ortholog(s) have thiosulfate sulfurtransferase activity, role in tRNA wobble position uridine thiolation and mitochondrion localization CAALFM_C209970CA Putative protein of unknown function; stationary phase enriched protein CAALFM_C209980WA Protein with a PI31 proteasome regulator domain; Hap43-repressed; flow model biofilm induced CAALFM_C209990CA Protein similar to S. cerevisiae Yor1; ABC-type plasma membrane transporter involved in resistance to aureobasidin A; white cell type-specific transcript; Spider biofilm induced CAALFM_C210000CA Ortholog of C. parapsilosis CDC317 : CPAR2_407200.1, C. dubliniensis CD36 : Cd36_24070, Pichia stipitis Pignal : PICST_31669 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00103 CAALFM_C210010CA Membrane-localized protein of unknown function CAALFM_C210020CA Has domain(s) with predicted catalytic activity CAALFM_C210030CA Cell surface mannoprotein; cell-wall glucan metabolism, adhesion; adhesin motif; O-glycosylation; induced by heat, germ tube formation, wall regeneration; mycelial antigen; diagnostic marker; fluconazole-repressed; Spider biofilm induced CAALFM_C210050WA Ortholog(s) have ubiquitin-specific protease activity, role in endocytosis, free ubiquitin chain depolymerization, protein deubiquitination and cell division site, cytosol, nucleus, peroxisome, transport vesicle localization CAALFM_C210060CA Putative pantetheine-phosphate adenylyltransferase (PPAT); which catalyzes 4th step in coenzyme A biosynthesis from pantothenate; rat catheter biofilm repressed CAALFM_C210070WA Predicted dehydrogenase; transcript upregulated in an RHE model of oral candidiasis; virulence-group-correlated expression; Spider biofilm repressed CAALFM_C210080WA Transcription factor; binds telomeres and regulatory sequences in DNA; involved in telomere maintenance; represses hyphal growth under yeast-favoring conditions; similar to (but shorter than) S. cerevisiae Rap1 CAALFM_C210090CA Ortholog(s) have mitochondrion localization CAALFM_C210100WA Predicted spliceosome-associated protein; role in pre-mRNA splicing; Spider biofilm induced CAALFM_C210110WA Cytochrome c; complements defects of S. cerevisiae cyc1 cyc7 double mutant; induced in high iron; alkaline repressed; repressed by nitric oxide; Hap43-dependent repression in low iron; regulated by Sef1, Sfu1 CAALFM_C210120WA Ortholog(s) have G-protein beta/gamma-subunit complex binding, actin binding activity, role in positive regulation of transcription from RNA polymerase II promoter by pheromones, protein folding and cytoplasm localization CAALFM_C210130WA Ortholog of C. parapsilosis CDC317 : CPAR2_407480, C. dubliniensis CD36 : Cd36_24170, Candida orthopsilosis Co 90-125 : CORT_0C06830 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_65786 CAALFM_C210140WA Ortholog(s) have protein complex scaffold, ubiquitin-specific protease activity and role in RNA splicing, histone H3-K4 methylation, histone H3-K79 methylation, histone deubiquitination CAALFM_C210150WA Secreted protein; fluconazole-induced CAALFM_C210160WA Secreted protein; fluconazole-induced CAALFM_C210170CA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C210180WA Predicted oxidoreductase/dehydrogenase; induced by nitric oxide; rat catheter and Spider biofilm induced CAALFM_C210190CA Putative protein phosphatase of the PTP family (tyrosine-specific); ortholog of S. cerevisiae Oca1; mutant is viable; mutant shows virulence defect CAALFM_C210200WA Predicted olichyl-diphosphooligosaccharide-protein glycotransferase; role in protein N-linked glycosylation; Spider biofilm repressed CAALFM_C210210CA RAS signal transduction GTPase; regulates cAMP and MAP kinase pathways; role in hyphal induction, virulence, apoptosis, heat-shock sensitivity; nonessential; plasma membrane-localized; complements viability of S. cerevisiae ras1 ras2 mutant CAALFM_C210220CA Ortholog(s) have methylated histone binding activity CAALFM_C210230WA Putative C2H2 transcription factor; expression upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced CAALFM_C210240WA Glycerol-3-phosphate dehydrogenase; glycerol biosynthesis; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Sflow model and Spider biofilm induced CAALFM_C210250CA Ortholog(s) have histone methyltransferase activity (H3-K36 specific) activity CAALFM_C210260CA Putative calmodulin-dependent protein kinase; involved in cell wall integrity and oxidative stress response CAALFM_C210270WA Pseudouridine synthase; catalyzes pseudouridylation in U2 snRNA, 5S rRNA, cytoplasmic tRNAs and in pre-tRNA(Tyr); F-12/CO2 early biofilm induced CAALFM_C210280CA Protein involved in regulation of unsaturated fatty acid biosynthesis; controls the expression of the Ole1p delta-9-fatty acid desaturase CAALFM_C210290WA Protein similar to mammalian SR-like RNA splicing factor; involved in filamentous growth and virulence; gene has intron; Spider biofilm repressed CAALFM_C210300CA Protein of unknown function; shows colony morphology-related gene regulation by Ssn6 CAALFM_C210310CA Putative kinesin-related motor protein involved in mitotic spindle positioning; repressed by alpha pheromone in SpiderM medium; periodic mRNA expression, peak at cell-cycle G2/M phase CAALFM_C210320CA Protein similar to S. cerevisiae meiosis-specific, spore-wall-localized protein Ssp2p, which is required for wild-type outer spore wall formation in S. cerevisiae; possibly an essential gene (UAU1 method); Hap43p-repressed CAALFM_C210330CA Protein of unknown function; Hap43-repressed gene CAALFM_C210340WA Putative uroporphyrinogen III synthase; induced in high iron or elevated CO2; alkaline, Hap43-repressed CAALFM_C210350CA Acetyl-CoA synthetase; induced by human neutrophils; fluconazole-repressed; regulated by Nrg1/Mig1; colony morphology-related gene regulation by Ssn6; only in stationary phase cultures; rat catheter biofilm repressed, Spider biofilm induced CAALFM_C210360CA Hydroxymethylbilane synthase; converts 4-porphobilinogen to hydroxymethylbilane in heme biosynthesis; induced in high iron, CO2; alkaline repressed; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced CAALFM_C210420WA Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth CAALFM_C210430CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; rat catheter biofilm repressed CAALFM_C210440CA Putative single-stranded DNA endonuclease; transcript regulated by Nrg1; macrophage-induced gene CAALFM_C210450WA Putative RecQ-mediated genome instability protein; Hap43-repressed gene; periodic mRNA expression, peak at cell-cycle G2/M phase; flow model biofilm induced CAALFM_C210460CA Ortholog(s) have methylenetetrahydrofolate reductase (NAD(P)H) activity and role in methionine biosynthetic process, one-carbon metabolic process CAALFM_C210470CA Ortholog(s) have phosphatidylinositol-3-phosphate binding activity and role in CVT pathway, autophagosome assembly, pexophagy, protein localization to pre-autophagosomal structure, vesicle organization CAALFM_C210480WA Predicted malate dehydrogenase; farnesol regulated; protein present in exponential and stationary growth phase yeast; Hap43p-repressed gene CAALFM_C210530CA Protein similar to S. cerevisiae Kin3p; induced under Cdc5p depletion; shows Mob2p-dependent hyphal regulation; mutants are hypersensitive to caspofungin CAALFM_C210540WA Putative transcription factor with zinc finger DNA-binding motif; possible ortholog of S. cerevisiae Mig2p CAALFM_C210550CA Ortholog(s) have protein kinase regulator activity, role in regulation of translational elongation and cytosolic ribosome, extracellular region, mitochondrion localization CAALFM_C210560CA Ortholog od S. cerevisiae Tis11, a mRNA-binding protein; transcription regulated by yeast-hyphal switch; flow model biofilm induced; Spider biofilm repressed CAALFM_C210570WA RecQ-related DNA helicase; Bloom's syndrome-related gene; haploinsufficient for wild-type lifespan; upregulated in farnesol treated biofilm CAALFM_C210580WA Putative E2 ubiquitin-conjugating enzyme CAALFM_C210590WA Zn(II)2Cys6 transcription factor; involved in control of glycolysis; ortholog of S. cerevisiae Gal4, but not involved in regulation of galactose utilization genes; caspofungin repressed; Spider biofilm repressed CAALFM_C210600WA Ortholog of S. cerevisiae Spg5; required for proteasome assembly during quiescence; transcript detected on high-resolution tiling arrays; Spider biofilm induced CAALFM_C210610WA Putative Rab GTPase activator; role in ER to Golgi vesicle-mediated transport; Spider biofilm induced CAALFM_C210620WA Predicted ribosomal protein, component of the small ribosomal subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; mutant is defective in filamentous growth and sensitive to osmotic stress CAALFM_C210630WA Ortholog(s) have cytosol, extracellular region, fungal-type vacuole, nucleus localization CAALFM_C210640CA Nuclear export protein; member of NTF2 family; monomeric in solution; interacts with Mex67p via the NTF2-like domain CAALFM_C210650WA Protein of unknown function; protein newly produced during adaptation to the serum CAALFM_C210660WA GATA-like transcription factor; localizes to daughter cell, hyphal tip cell nuclei; mRNA localization mediated by She3; required for WT virulence and filamentous growth on solid media; Ras1 repressed in yeast, Cyr1 repressed yeast, hyphae CAALFM_C210670WA Putative ubiquitin-like polyubiquitin-binding protein; induced by nitric oxide independent of Yhb1; Spider biofilm repressed CAALFM_C210680WA Ortholog(s) have role in transcription from RNA polymerase II promoter and transcription factor TFIID complex localization CAALFM_C210690WA Predicted trehalose-phosphate synthase regulatory subunit; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; flow model biofilm induced (reports differ) CAALFM_C210700CA Ortholog(s) have role in positive regulation of DNA-templated transcription, elongation, positive regulation of transcription from RNA polymerase I promoter, positive regulation of translational fidelity, protein phosphorylation CAALFM_C210710WA Translation initiation factor eIF1a; possibly transcriptionally regulated upon hyphal formation; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C210720CA Protein with a predicted magnesium transporter domain; mutants are viable CAALFM_C210730WA Ortholog of C. parapsilosis CDC317 : CPAR2_407790, C. dubliniensis CD36 : Cd36_24630, Candida orthopsilosis Co 90-125 : CORT_0C07130 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_149801 CAALFM_C210740CA Protein with a predicted role in cell wall integrity; repressed in core stress response CAALFM_C210750CA Putative serine/threonine protein kinase; induced during the mating process CAALFM_C210760CA Phosphorylated protein of unknown function CAALFM_C210770WA Putative RNA polymerase III subunit C11; repressed in core caspofungin response; Spider biofilm induced CAALFM_C210780CA Putative DNA cross-link repair protein; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; telomere-proximal gene; mutation does not affect white-to-opaque phenotypic switching CAALFM_C210790CA Component of UDP-GlcNAc transferase; required for the 2nd step of dolichyl-linked oligosaccharide synthesis; Spider biofilm induced CAALFM_C210810WA Putative pre-mRNA splicing factor; intron in 5'-UTR; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C210820CA S. cerevisiae ortholog YMR259C interacts with Trm7 for 2'-O-methylation of C32 of substrate tRNAs; downregulated by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 CAALFM_C210830WA Ortholog of C. parapsilosis CDC317 : CPAR2_407710, C. dubliniensis CD36 : Cd36_24540, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116924 and Lodderomyces elongisporus NRLL YB-4239 : LELG_02895 CAALFM_C210840WA Putative DNA-dependent ATPase with a predicted role in DNA recombination and repair; transcriptionally induced by interaction with macrophages CAALFM_C210850CA Ortholog of Vms1; component of a Cdc48-complex involved in protein quality control in S. cerevisiae; Spider biofilm repressed CAALFM_C210860CA Uroporphyrinogen decarboxylase; catalyzes the 5th step in the heme biosynthetic pathway; flow model and Spider biofilm repressed CAALFM_C210870WA Ortholog(s) have fungal-type vacuole membrane localization CAALFM_C300010CA Protein of unknown function; induced by Mnl1 under weak acid stress; transcript detected on high-resolution tiling arrays; Spider biofilm repressed CAALFM_C300030CA Protein with a predicted DEAD-like DNA/RNA helicase domain; shows colony morphology-related gene regulation by Ssn6; overlaps orf19.5472; Spider biofilm repressed CAALFM_C300050CA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on transcription data; almost identical to orf19.6113, orf19.4055, orf19.5370 CAALFM_C300060WA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo; rat catheter biofilm repressed CAALFM_C300090WA Predicted ribosomal protein; hyphal downregulated; repressed upon phagocytosis by murine macrophage; transcriptionally activated by Tbf1; Spider biofilm repressed CAALFM_C300100WA Ortholog(s) have first spliceosomal transesterification activity, role in generation of catalytic spliceosome for first transesterification step and U2-type catalytic step 1 spliceosome, mitotic spindle pole body localization CAALFM_C300110CA Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip; Hap43p-repressed CAALFM_C300120WA Protein of unknown function CAALFM_C300130CA mRNA polyadenylation regulating protein; Hap43-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed CAALFM_C300140WA Protein of unknown function CAALFM_C300150WA Ortholog of Candida albicans WO-1 : CAWG_02350 CAALFM_C300160CA Ortholog(s) have Golgi apparatus, endoplasmic reticulum, lipid particle localization CAALFM_C300170CA Ortholog(s) have GTPase regulator activity, mRNA binding activity CAALFM_C300180CA Putative allantoinase; transcript regulated by Nrg1 and Mig1; macrophage/pseudohyphal-repressed CAALFM_C300190WA Ortholog of Candida guilliermondii ATCC 6260 : PGUG_05321, Candida lusitaniae ATCC 42720 : CLUG_00887 and Candida albicans WO-1 : CAWG_02354 CAALFM_C300200CA Putative 2-enoyl thioester reductase; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressed CAALFM_C300210CA Predicted integral membrane protein; Spider biofilm induced CAALFM_C300220WA Putative MFS glucose/myo-inositol transporter; 20 member family; 12 transmembrane segments, extended N terminus; expressed in rich medium; Hap43, phagocytosis, rat catheter, Spider and flow model biofilm induced CAALFM_C300230CA Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Ssn6 CAALFM_C300240CA Putative ARF GTPase activator; role in COPI coating of Golgi vesicle, ER to Golgi vesicle-mediated transport, retrograde Golgi to ER vesicle-mediated transport; Spider biofilm repressed CAALFM_C300250CA Protein involved in transport across membranes; Spider biofilm repressed CAALFM_C300260CA Putative kynurenine 3-monooxygenase, involved in NAD biosynthesis; transposon mutation affects filamentous growth; Hap43p-repressed gene; oral infection upregulated; mutants have reduced capacity to damage oral epithelial cells CAALFM_C300270CA Ortholog of C. dubliniensis CD36 : Cd36_80240, C. parapsilosis CDC317 : CPAR2_504040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_130872 and Debaryomyces hansenii CBS767 : DEHA2C06006g CAALFM_C300280CA SUMO deconjugation enzyme that removes the small ubiquitin-like modifier (SUMO) from proteins CAALFM_C300290WA Putative ATPase of the 19S regulatory particle of the 26S proteasome; oxidative stress-induced via Cap1; Spider biofilm repressed CAALFM_C300300WA Ortholog of C. parapsilosis CDC317 : CPAR2_504010, C. dubliniensis CD36 : Cd36_80270, Lodderomyces elongisporus NRLL YB-4239 : LELG_02294 and Pichia stipitis Pignal : PICST_29581 CAALFM_C300310CA Putative ubiquitin-protein ligase; role in protein sumoylation, protein ubiquitination; Spider biofilm induced CAALFM_C300320WA Glycerol 3-phosphatase; roles in osmotic tolerance, glycerol accumulation in response to salt; Spider/flow model biofilm induced; regulated by macrophage, stress, yeast-hyphal switch, pheromone, Gcn4, Hog1, Nrg1, Tup1 CAALFM_C300330WA Essential nucleolar protein; involved in tRNA export from the nucleus and ribosomal small subunit biogenesis; physically interacts with TAP-tagged Nop1; Spider biofilm induced CAALFM_C300340WA Ortholog(s) have protein binding involved in protein folding activity, role in mitochondrial respiratory chain complex III assembly and mitochondrial matrix localization CAALFM_C300350WA tRNA 2'-phosphotransferase; enzyme of tRNA splicing; functionally complements viability of S. cerevisiae tpt1 null mutant CAALFM_C300360WA Protein of unknown function; Hap43-repressed; Spider biofilm induced CAALFM_C300370CA Small-subunit processome component; repressed by prostaglandins CAALFM_C300380CA Ortholog(s) have DNA replication origin binding, ubiquitin-protein transferase activity CAALFM_C300390WA Putative Golgi membrane protein with a predicted role in manganese homeostasis; Hap43p-repressed gene; clade-associated gene expression CAALFM_C300400CA Putative patatin-like phospholipase; macrophage-regulated gene; fungal-specific (no human or murine homolog) CAALFM_C300410CA Ortholog of Candida albicans WO-1 : CAWG_02376 CAALFM_C300420WA Ortholog(s) have 3'-tRNA processing endoribonuclease activity, role in mitochondrial tRNA 3'-end processing, nuclear tRNA 3'-trailer cleavage, endonucleolytic and mitochondrion, nucleus localization CAALFM_C300430WA Telomerase subunit; required for telomere maintenance in vivo; separable roles in telomerase activity and processivity; not required for catalytic activity in vitro; related to mammalian Tpp1p CAALFM_C300440WA Ortholog of C. dubliniensis CD36 : Cd36_80400, Candida tropicalis MYA-3404 : CTRG_06188 and Candida albicans WO-1 : CAWG_02379 CAALFM_C300450CA Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translation and mitochondrial large ribosomal subunit localization CAALFM_C300460WA Putative F0-ATP synthase FO subunit B; caspofungin repressed; protein level decreased in stationary phase yeast cultures; Spider biofilm repressed CAALFM_C300470WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and endoplasmic reticulum localization CAALFM_C300480CA Putative nuclear thiol peroxidase; alkaline downregulated; sumoylation target; Spider and flow model biofilm induced CAALFM_C300490WA Subunit of the NuA4 histone acetyltransferase complex; member of MYST family; Spider biofilm induced CAALFM_C300500CA Ortholog(s) have role in mRNA splicing, via spliceosome and Prp19 complex, spliceosomal complex localization CAALFM_C300510WA Ortholog of S. cerevisiae : ECM9, C. glabrata CBS138 : CAGL0L02255g, C. dubliniensis CD36 : Cd36_80470, C. parapsilosis CDC317 : CPAR2_503390 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_133107 CAALFM_C300520WA Ortholog(s) have NEDD8 transferase activity, role in protein neddylation and cytosol, nucleus localization CAALFM_C300530CA Ortholog(s) have microtubule plus-end binding activity CAALFM_C300540CA Protein with a positive role in the multivesicular body sorting pathway; rat catheter biofilm repressed CAALFM_C300550CA Putative serine/threonine kinase; predicted role in cellular ion homeostasis; Spider biofilm repressed CAALFM_C300560CA Putative protein with a predicted role in 40S ribosomal subunit biogenesis; rat catheter biofilm induced CAALFM_C300570CA Predicted plasma membrane associated protein phosphatase; required for normal filamentous growth; mRNA binds She3 and is localized to hyphal tips CAALFM_C300590WA Ortholog of Candida albicans WO-1 : CAWG_02394 CAALFM_C300600WA Secreted protein required for normal cell wall structure and for virulence; member of the IFF family; Hap43p-repressed gene CAALFM_C300610WA Putative conserved oligomeric Golgi complex subunit; decreased transcription is observed upon fluphenazine treatment CAALFM_C300620CA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and cytosol, integral component of mitochondrial inner membrane, mitochondrial intermembrane space, nucleus localization CAALFM_C300630WA Ortholog(s) have role in early endosome to late endosome transport, regulation of protein complex assembly, vacuolar acidification and RAVE complex, extrinsic component of membrane localization CAALFM_C300640WA Putative cysteine sulfinate decarboxylase; transcript positively regulated by Tbf1; Spider biofilm induced CAALFM_C300650WA N-acetylglucosamine (GlcNAc)-specific transporter; role in GlcNAc (but not serum) induced hyphal growth; localizes to plasma membrane; induced by GlcNAc, macrophage engulfment; 12 transmembrane, major facilitator superfamily CAALFM_C300660WA Predicted RNA splicing and ER to Golgi transport protein; Hap43-induced gene CAALFM_C300670CA Forkhead transcription factor; morphogenesis regulator; required for wild-type hyphal transcription, cell separation, and for virulence in cell culture; mutant lacks true hyphae, is constitutively pseudohyphal; upregulated in RHE model CAALFM_C300680CA Ortholog of Candida albicans WO-1 : CAWG_02403 CAALFM_C300690CA Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity CAALFM_C300700WA Putative vacuolar sorting protein; downregulated upon adherence to polystyrene CAALFM_C300710WA Chitin synthase required for synthesis of long-chitin fibrils; nonessential; 8 or 9 membrane spanning regions; mRNA present in yeast and hyphae; induced during cell wall regeneration; flow model biofilm repressed CAALFM_C300720WA Plasma membrane H(+)-ATPase; highly expressed, comprises 20-40% of total plasma membrane protein; levels increase at stationary phase transition; fluconazole induced; caspofungin repressed; upregulated in RHE model; Spider biofilm repressed CAALFM_C300730WA Ortholog(s) have mRNA binding activity CAALFM_C300750WA Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, involved in the regulation of lysine biosynthesis genes CAALFM_C300760WA Protein similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; caspofungin repressed; rat catheter biofilm repressed CAALFM_C300770CA Proteasome subunit YC7alpha; protein present in exponential and stationary growth phase yeast cultures; flow model and Spider biofilm repressed CAALFM_C300780WA Putative protein deacetylase, deacetylates tubulin in vitro; genetic evidence suggests that Set3p and Hos2p function together as a complex involved in regulation of white-opaque switching, filamentous growth and virulence CAALFM_C300790WA Ortholog of S. cerevisiae Elm1; a serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis in S. cerevisiae; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C300800WA Putative protein phosphatase of the PTP family (tyrosine-specific); ortholog of S. cerevisiae Mih1; mRNA binds She3 CAALFM_C300810CA 3-hydroxyacyl-CoA epimerase; fatty acid beta-oxidation; induced by phagocytosis; regulated by Mig1, by white-opaque switch, by DNA methylation; transcriptional activation by oleate requires Ctf1; rat catheter and Spider biofilm induced CAALFM_C300820WA Putative glycerol-3-phosphate O-acyltransferase; fungal-specific (no human or murine homolog) CAALFM_C300830CA Ortholog(s) have DNA ligase (ATP) activity and role in DNA ligation, DNA recombination, base-excision repair, lagging strand elongation, maintenance of DNA trinucleotide repeats, mitotic cell cycle, nucleotide-excision repair CAALFM_C300840CA Ortholog of S. cerevisiae : AIM11, C. glabrata CBS138 : CAGL0I04928g, C. dubliniensis CD36 : Cd36_80770, C. parapsilosis CDC317 : CPAR2_102260 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_114262 CAALFM_C300850CA Ortholog(s) have role in eisosome assembly and eisosome, membrane raft, mitochondrion, plasma membrane localization CAALFM_C300860WA Centromeric histone H3 variant; role in structural changes of centromeric nucleosomes during cell cycle; 4 nucleosomes bind 1 centromere, each has 1 Cse4 molecule during most of cell cycle, 2 molecules in anaphase; Spider biofilm repressed CAALFM_C300880WA Putative 2-oxoglutarate dehydrogenase; regulated by Efg1 under yeast but not hyphal growth conditions; transcript induced in an RHE model of oral candidiasis; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm induced CAALFM_C300890CA Ortholog of C. dubliniensis CD36 : Cd36_80810, C. parapsilosis CDC317 : CPAR2_101800, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103482 and Debaryomyces hansenii CBS767 : DEHA2F17864g CAALFM_C300900CA Putative oxidoreductase; transcriptionally induced by interaction with macrophage; rat catheter biofilm repressed CAALFM_C300910WA Ortholog of C. dubliniensis CD36 : Cd36_80830, Debaryomyces hansenii CBS767 : DEHA2F17930g, Candida tropicalis MYA-3404 : CTRG_04030 and Candida lusitaniae ATCC 42720 : CLUG_04224 CAALFM_C300920WA Putative fungal-specific transmembrane protein; induced by Rgt1; Spider biofilm induced CAALFM_C300930WA Putative fungal-specific transmembrane protein; fluconazole repressed, Hap43-repressed; flow model biofilm induced; Spider biofilm induced CAALFM_C300940WA Predicted ubiquitin-protein ligase; Hap43-repressed gene; oxidative stress-induced via Cap1; flow model biofilm induced CAALFM_C300950CA Putative peptidyl-prolyl cis-trans isomerase CAALFM_C300960WA Has domain(s) with predicted transferase activity and role in biosynthetic process CAALFM_C300980WA Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1; regulated by iron; macrophage-induced; mutant defective in filamentous growth; Spider biofilm induced CAALFM_C300990CA Ortholog(s) have prospore membrane localization CAALFM_C301000WA Putative GTPase; Hap43-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); flucytosine induced; repressed by prostaglandins; Spider biofilm induced CAALFM_C301020WA Protein of unknown function; opaque-specific transcript; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hog1-repressed; Spider biofilm induced CAALFM_C301030WA Protein similar to S. cerevisiae Arp3p, a component of the Arp2/3 complex involved in actin-dependent processes; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C301040CA Protein described a similar to S. cerevisiae Prm9; not the ortholog though; mutant is viable CAALFM_C301050CA Ortholog of C. parapsilosis CDC317 : CPAR2_401850, C. dubliniensis CD36 : Cd36_80970, Lodderomyces elongisporus NRLL YB-4239 : LELG_04407 and Candida orthopsilosis Co 90-125 : CORT_0E01890 CAALFM_C301060WA Ortholog of C. dubliniensis CD36 : Cd36_29340, Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00040 and Candida albicans WO-1 : CAWG_00248 CAALFM_C301070CA Ortholog(s) have role in protein folding, tubulin complex assembly CAALFM_C301080WA Putative mitochondrial ribosomal protein of the large subunit; Ssr1-repressed; rat catheter biofilm induced CAALFM_C301090WA Ortholog of C. parapsilosis CDC317 : CPAR2_103040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116324, Debaryomyces hansenii CBS767 : DEHA2G01980g and Pichia stipitis Pignal : PICST_45936 CAALFM_C301100WA Ortholog of C. dubliniensis CD36 : Cd36_81000, C. parapsilosis CDC317 : CPAR2_103050, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116326 and Debaryomyces hansenii CBS767 : DEHA2G01958g CAALFM_C301110CA Has domain(s) with predicted role in Group I intron splicing and intracellular ribonucleoprotein complex localization CAALFM_C301120WA Predicted methyltransferase; rat catheter biofilm induced CAALFM_C301130CA ZZ-type zinc finger protein; rat catheter and Spider biofilm induced CAALFM_C301140WA Has domain(s) with predicted role in cell redox homeostasis CAALFM_C301150CA Ortholog of S. cerevisiae Apd1; required for normal localization of actin patches and normal tolerance of sodium ions and hydrogen peroxide; Hap43-induced; Spider biofilm induced CAALFM_C301160WA Phosphatidylinositol-4-phosphate 5-kinase; activity induced by phosphatidic acid (Pld1 product); macrophage/pseudohyphal-repressed; mRNA binds to She3, localized to yeast cell buds and hyphal tips; Hap43-induced; Spider biofilm induced CAALFM_C301170WA Ortholog(s) have role in inner mitochondrial membrane organization and integral component of mitochondrial inner membrane localization CAALFM_C301180CA Protein of unknown function; induced by Mnl1 under weak acid stress CAALFM_C301190CA Ortholog(s) have cytoplasm localization CAALFM_C301200WA Putative snoRNA-binding protein; S. cerevisiae Utp20 ortholog; likely essential for growth; repressed in core stress response; mutation confers resistance to 5-fluorocytosine (5-FC) and parnafungin CAALFM_C301210CA HMG-box protein; Spider biofilm repressed CAALFM_C301220WA Putative transcription factor with zinc finger DNA-binding motif CAALFM_C301230CA Ortholog of C. dubliniensis CD36 : Cd36_81190, C. parapsilosis CDC317 : CPAR2_503840, Debaryomyces hansenii CBS767 : DEHA2A09042g and Pichia stipitis Pignal : PICST_42519 CAALFM_C301250WA Vacuolar calcium P-type ATPase; transcript regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole, lithium; increased sensitivity to calcium; Spider biofilm induced CAALFM_C301260CA Putative adhesin-like protein CAALFM_C301280WA Ortholog(s) have role in cellular response to drug, response to purine-containing compound and cytoplasm, nucleus localization CAALFM_C301300CA Carbonic anhydrase; converts of CO2 to bicarbonate; essential for virulence in host niches with limited CO2, normal white-opaque switch; Mnl1-induced in weak acid stress; Hap43-induced gene; F-12/CO2, rat catheter, Spider biofilm induced CAALFM_C301310WA Ortholog(s) have role in mitotic recombination CAALFM_C301320CA Putative glucoamylase; induced in oralpharyngeal candidasis; rat catheter and Spider biofilm induced CAALFM_C301330WA Predicted Zn(II)2Cys6 transcription factor; repressed by fluphenazine treatment; required for yeast cell adherence to silicone substrate CAALFM_C301340WA Ortholog of C. dubliniensis CD36 : Cd36_81270, C. parapsilosis CDC317 : CPAR2_502880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_101483 and Debaryomyces hansenii CBS767 : DEHA2A11990g CAALFM_C301350CA Orotidine-5'-phosphate decarboxylase; pyrimidine biosynthesis; gene used as genetic marker; decreased expression when integrated at ectopic chromosomal locations can cause defects in hyphal growth and virulence; Spider biofilm repressed CAALFM_C301360CA Putative transcription factor; role in iron utilization, pathogenesis; both IRO1 and adjacent URA3 are mutated in strain CAI4; suppresses S. cerevisiae aft1 mutant low-iron growth defect; hyphal-induced; reports differ about iron regulation CAALFM_C301370CA Putative GPI-anchored protein CAALFM_C301390CA Putative ARF GTP/GDP exchange factor; induced in low iron; flow model biofilm repressed CAALFM_C301400WA Regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) CAALFM_C301410CA Putative NADH-ubiquinone oxidoreductase; in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; nitric oxide-repressed; plasma membrane-localized; protein decreases in stationary phase CAALFM_C301420CA Sterol carrier domain protein; alkaline downregulated; colony morphology-related gene regulation by Ssn6; Spider biofilm induced CAALFM_C301430WA Protein of unknown function; Spider biofilm induced CAALFM_C301440CA Ortholog of Candida albicans WO-1 : CAWG_02476 CAALFM_C301450CA Putative protein with a predicted role in nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; Plc1p-regulated CAALFM_C301460CA Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by white-opaque switch; Spider biofilm induced CAALFM_C301470WA Similar to but not orthologous to S. cerevisae Arf3; transcript filament induced; Tup1 regulated; rat catheter biofilm repressed (see Locus History Note for Assembly 19 correction) CAALFM_C301480CA Ortholog(s) have ribose-5-phosphate isomerase activity, role in pentose-phosphate shunt, pyridoxine biosynthetic process and cytoplasm, nucleus localization CAALFM_C301490WA Ribosomal protein S7; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C301500CA Protein similar to S. cerevisiae Bzz1p, which is an SH3 domain protein involved in the regulation of actin polymerization CAALFM_C301510WA Ortholog(s) have phosphatidate phosphatase activity, role in actin cytoskeleton organization, cellular lipid metabolic process and actin cortical patch localization CAALFM_C301520CA Ortholog(s) have mRNA binding activity, role in cytoplasmic translation, poly(A)+ mRNA export from nucleus and cytosol, polysomal ribosome localization CAALFM_C301530CA RAM cell wall integrity signaling network protein; cell separation, azole sensitivity; needed for hyphal growth; insertion mutation near 3' end of gene increases caspofungin sensitivity; pheromone/hyphal induced; flow biofilm repressed CAALFM_C301540WA Plasma-membrane-localized protein; filament induced; Hog1, ketoconazole, fluconazole and hypoxia-induced; regulated by Nrg1, Tup1, Upc2; induced by prostaglandins; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C301550CA Protein similar to alpha agglutinin anchor subunit; secreted; exogenously expressed protein is a substrate for Kex2 processing in vitro; fluconazole-induced; induced by alpha pheromone in SpiderM medium; Hap43-induced CAALFM_C301560WA Ortholog of S. cerevisiae Prp43, an RNA helicase in the DEAH-box family that functions in both RNA polymerase I and polymerase II transcript metabolism; Hap43-induced gene CAALFM_C301570WA Ortholog(s) have mitochondrion localization CAALFM_C301580WA Predicted Zn(II)2Cys6 transcription factor; mutant shows reduced colony wrinkling on Spider medium and is unable to utilize mannitol as a carbon source; mutants have increased colonization of mouse kidneys CAALFM_C301590WA Ortholog of C. dubliniensis CD36 : Cd36_81500, C. parapsilosis CDC317 : CPAR2_503620, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93693 and Debaryomyces hansenii CBS767 : DEHA2D15268g CAALFM_C301600WA Catalytic subunit of protein phosphatase of the Type 2A-related family (serine/threonine-specific), involved in dephosphorylation of septin Sep7p; caspofungin repressed; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C301610WA Membrane protein; Hap43p-repressed gene; repressed by nitric oxide CAALFM_C301620WA Ortholog of C. dubliniensis CD36 : Cd36_81530, C. parapsilosis CDC317 : CPAR2_503590, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115755 and Debaryomyces hansenii CBS767 : DEHA2D15334g CAALFM_C301630WA Subunit of vacuolar H+-ATPase; stationary phase enriched protein; sumoylation target; Spider biofilm repressed CAALFM_C301640CA Ortholog of C. dubliniensis CD36 : Cd36_81550, C. parapsilosis CDC317 : CPAR2_503570, Candida tenuis NRRL Y-1498 : cten_CGOB_00261 and Debaryomyces hansenii CBS767 : DEHA2D15378g CAALFM_C301660WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C301670WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C301680CA Predicted potassium ion transporter; Spider biofilm induced CAALFM_C301690WA Ortholog(s) have role in positive regulation of catalytic activity CAALFM_C301700WA Cullin, a scaffold subunit of the SCF ubiquitin-ligase complexes; depletion leads to increased filamentous growth and premature cell death CAALFM_C301710CA Putative serine/threonine phosphatase; induced in high iron CAALFM_C301720CA Alpha subunit of COPI vesicle coatomer complex; role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER transport; flow model biofilm repressed CAALFM_C301730CA Putative GPI anchored cell wall glycosidase; role in adhesion, hyphal growth on Spider (not serum) medium; chitin-binding, glycosyl hydrolase domains; induced during cell wall regeneration; mRNA in yeast-form cells; Spider biofilm induced CAALFM_C301740CA Predicted ORF added to Assembly 21 based on sequence re-analysis CAALFM_C301750CA Class E vacuolar protein sorting factor; role in transport from multivesicular body to vacuole; not involved in Rim101 pathway; macrophage and pseudohyphal-repressed; flow model biofilm induced CAALFM_C301760WA Similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C301770CA Protein of unknown function; expression downregulated in an ssr1 null mutant CAALFM_C301780CA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrial intermembrane space, nucleus localization CAALFM_C301790CA Protein with a predicted SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily domain; Hap43-repressed gene CAALFM_C301800CA Ortholog of Dig2, a MAP kinase-responsive inhibitor of Ste12; regulates mating-specific genes and invasive growth in S. cerevisiae; induced by alpha pheromone in SpiderM medium CAALFM_C301810CA Alpha-1,2-mannosyl transferase; predicted type II Golgi membrane protein; adds 2nd mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; Hap43-induced CAALFM_C301820WA Protein of unknown function; expression downregulated in an ssr1 null mutant CAALFM_C301830CA Alpha-1,2-mannosyl transferase; adds 3rd mannose in cell-wall mannoprotein biosynthesis; partially redundant with Mnt1; role in adherence and virulence; expressed in yeast and hyphae; fungal-specific; Hap43-induced; Spider biofilm induced CAALFM_C301850WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C301860CA Ortholog(s) have RNA helicase activity, RNA-dependent ATPase activity, inositol hexakisphosphate binding activity and role in mRNA export from nucleus, translational termination CAALFM_C301880WA Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in nik1 and sln1 homozygous null mutants, but not in the chk1 null mutant; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C301890CA Ortholog(s) have cell cortex, cellular bud neck, cellular bud tip, mating projection tip localization CAALFM_C301900CA Protein with a predicted FYVE/PHD zinc finger domain; Hap43-repressed; Spider biofilm induced CAALFM_C301910CA Ortholog(s) have phosphatidic acid binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, sphingolipid binding activity CAALFM_C301930WA Putative acyl-CoA oxidase; enzyme of fatty acid beta-oxidation; induced during macrophage infection; opaque specific transcript; putative peroxisome targeting signal; Spider biofilm induced CAALFM_C301940CA Predicted membrane protein; induced by prostaglandins CAALFM_C301950CA Has domain(s) with predicted integral component of membrane localization CAALFM_C301960CA Predicted acyl-CoA oxidase; farnesol regulated; stationary phase enriched protein; Spider biofilm induced CAALFM_C301970CA Ortholog of C. dubliniensis CD36 : Cd36_81960, Pichia stipitis Pignal : psti_CGOB_00163, Candida tropicalis MYA-3404 : CTRG_02378 and Candida albicans WO-1 : CAWG_02525 CAALFM_C301980CA Predicted component of the TOM (translocase of outer membrane) complex, involved in protein import into mitochondria CAALFM_C301990WA Putative GTPase-activating protein; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C302000WA Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance; flow model biofilm repressed CAALFM_C302010CA Ortholog(s) have role in ascospore wall assembly CAALFM_C302020WA Ortholog(s) have mRNA binding, rRNA primary transcript binding activity CAALFM_C302030WA Ortholog(s) have serine-type endopeptidase activity, role in regulation of mitochondrion organization, signal peptide processing and mitochondrial inner membrane localization CAALFM_C302040CA Ortholog of S. cerevisiae Loc1, a nuclear protein involved in asymmetric localization of ASH1 mRNA in S. cerevisiae; Hap43-induced gene; Spider biofilm induced CAALFM_C302060WA Has domain(s) with predicted hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides activity and role in metabolic process CAALFM_C302070CA Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process CAALFM_C302080WA Has domain(s) with predicted zinc ion binding activity, role in ER to Golgi vesicle-mediated transport, intracellular protein transport and COPII vesicle coat localization CAALFM_C302090CA Ortholog(s) have cytosol, nucleus localization CAALFM_C302100WA Protein with sterile alpha motif (SAM) and Ras-associated domain (RAD); similar to S. cerevisiae Rad50p, which is involved in signal transduction via interaction with and regulation of MAPKKK CAALFM_C302110WA Ribosomal protein L12, 60S ribosomal subunit; downregulated by human whole blood or polymorphonuclear cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by macrophage; Tbf1p-activated; Hap43p-induced CAALFM_C302120WA Has domain(s) with predicted fatty-acyl-CoA binding activity CAALFM_C302130WA Putative U3 snoRNA-associated protein; Hap43-induced; physically interacts with TAP-tagged Nop1; Spider biofilm induced CAALFM_C302140CA Has domain(s) with predicted catalytic activity CAALFM_C302150CA Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol, ergosterol biosynthesis; mutation confers nystatin resistance; Hap43, GlcNAc-, fluconazole-induced; upregulated in azole-resistant strain; Spider biofilm repressed CAALFM_C302160CA Ortholog(s) have mRNA binding activity and cytoplasmic mRNA processing body localization CAALFM_C302170CA Putative aminopeptidase yscI precursor; mutant is viable; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C302180CA Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; Spider biofilm repressed CAALFM_C302190CA Putative ubiquinone oxidoreductase; repressed by nitric oxide; Hap43p-repressed CAALFM_C302200WA Ortholog of C. parapsilosis CDC317 : CPAR2_405060 and Candida orthopsilosis Co 90-125 : CORT_0C04470 CAALFM_C302210CA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; flow model biofilm repressed CAALFM_C302220WA AP-1 bZIP transcription factor; apoptotic, oxidative stress response/resistance, multidrug resistance; nuclear in oxidative stress; complements S. cerevisiae yap1 mutant; oralpharyngeal candidasis-, human neutrophil, Spider biofilm induced CAALFM_C302230CA Putative condensin G CAALFM_C302240CA G-protein alpha subunit; regulates filamentous growth, copper resistance; involved in cAMP-mediated glucose signaling; reports differ on role in cAMP-PKA pathway, MAP kinase cascade; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1 CAALFM_C302250CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C302260CA Putative kinase subunit of RNA polymerase II carboxy-terminal domain kinase I; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C302270WA Ortholog(s) have cytosol localization CAALFM_C302280CA Glucosamine-6-phosphate synthase, homotetrameric enzyme of chitin/hexosamine biosynthesis; inhibited by UDP-GlcNAc, FMDP, N-acyl peptide, kanosamine-6-P; functional homolog of S. cerevisiae Gfa1p; Cagrowth-phase regulated; catalytic Cys CAALFM_C302290WA Protein similar to S. cerevisiae Ydr282cp; transposon mutation affects filamentous growth; Hap43p-repressed gene CAALFM_C302300WA Protein of unknown function; repressed by a1/alpha2 in white-phase cells, a-specific, alpha factor-induced; Hap43-repressed; flow model biofilm induced; Tn mutation affects filamentous growth CAALFM_C302310WA Ammonium permease; Mep1 more efficient permease than Mep2, Mep2 has additional regulatory role; 11 predicted transmembrane regions; low mRNA abundance; hyphal downregulated; flow model biofilm induced CAALFM_C302320WA Putative acetolactate synthase; regulated by Gcn4p; induced by amino acid starvation (3-AT treatment); stationary phase enriched protein CAALFM_C302330CA Protein of unknown function; Spider biofilm induced CAALFM_C302340WA Putative protein of unknown function, transcription is activated in the presence of elevated CO2 CAALFM_C302350WA Ortholog(s) have role in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) CAALFM_C302360CA Ortholog(s) have cytosol, nucleus localization CAALFM_C302370CA Putative transporter of divalent cations; hyphal-induced expression; rat catheter biofilm induced CAALFM_C302390WA Protein of unknown function; Plc1-regulated CAALFM_C302400CA Putative cytochrome c oxidase; flucytosine induced; repressed by nitric oxide CAALFM_C302410CA Ortholog(s) have ubiquitin-protein transferase activity and role in protein ubiquitination involved in ubiquitin-dependent protein catabolic process CAALFM_C302430WA Phosphorylated protein of unknown function; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_C302440CA Subunit of the RNA polymerase II mediator complex CAALFM_C302450WA Ortholog of S. cerevisiae Hrt1; component of a nuclear ubiquitin-protein ligase complex involved in cell cycle control; induced by hydroxyurea; Spider biofilm induced CAALFM_C302460CA Putative prephenate dehydratase; Hap43p-repressed gene; expression downregulated in an ssr1 null mutant CAALFM_C302470CA Ribosomal protein L9; repressed upon phagocytosis by murine macrophages; repressed by nitric oxide; protein levels decrease in stationary phase; Hap43-induced; Spider biofilm repressed CAALFM_C302480CA Cytochrome-c peroxidase N terminus; Rim101, alkaline pH repressed; induced in low iron or by macrophage interaction; oxygen-induced activity; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C302490CA Putative ATP-dependent helicase; induced by nitric oxide CAALFM_C302500WA Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix CAALFM_C302510CA Secreted aspartyl protease; regulated by growth phase, temperature, white-opaque switch; highly expressed in opaque cells and upon deep epidermal invasion; greater expression in vaginal than oral infection; prominent role in biofilms CAALFM_C302530WA Ortholog(s) have endoplasmic reticulum localization CAALFM_C302540CA Ortholog(s) have role in cellular response to oxidative stress and cytosol, mitochondrion, nucleus localization CAALFM_C302550CA Protein of unknown function; ortholog of S. cerevisiae Dcg1; transcript regulated by Nrg1 and Mig1 CAALFM_C302560WA Putative DNA damage checkpoint protein; transcript induced during filamentous growth; regulated by Nrg1, Tup1 CAALFM_C302570WA Predicted metalloendopeptidase; Spider biofilm induced CAALFM_C302580CA Ortholog(s) have role in endosome organization, regulation of protein localization and BLOC-1 complex, endosome localization CAALFM_C302590WA Ortholog of S. cerevisiae and S. pombe Apl5; subunit of the AP-3 adaptor complex involved in Golgi-to-vacuole transport; phosphorylated protein; mutant is viable CAALFM_C302600CA Putative fatty acyltransferase; protein repressed during the mating process CAALFM_C302610CA Glutathione-independent glyoxalase; binds human immunoglobulin E; alkaline, fluconazole, Hog1 repressed; hypoxia, oxidative stress via Cap1, Hap43 induced; stationary-phase enriched; rat catheter, Spider biofilm induced CAALFM_C302620CA Protein of unknown function; S. cerevisiae ortholog Fmp37 which localizes to mitochondria; Hap43-repressed; Spider biofilm repressed CAALFM_C302630CA Protein of unknown function; Hog1p-repressed; Spider biofilm induced CAALFM_C302640CA Zn(II)2Cys6 transcription factor; transcript regulated during hypha formation; 5'-UTR intron; mutants show decreased colonization of mouse kidneys; flow model biofilm induced; Spider biofilm induced CAALFM_C302660WA Protein of unknown function; Spider biofilm induced CAALFM_C302670WA Protein with a predicted role in 60S ribosomal subunit assembly; flow model biofilm induced CAALFM_C302680CA Sphingolipid delta-8 desaturase; catalyzes desaturation at C8 in the long-chain base moiety of ceramides in glucosylceramide synthesis, important for virulence; ketoconazole and hypoxia induced; Hap43-repressed; Spider biofilm induced CAALFM_C302690CA Ortholog(s) have dolichol kinase activity, role in dolichyl monophosphate biosynthetic process and endoplasmic reticulum membrane localization CAALFM_C302700WA Protein similar to S. cerevisiae Smc3p, which is an ATPase involved in sister chromatid cohesion; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C302710WA Protein of unknown function; gene has intron; Spider biofilm induced CAALFM_C302720WA Has domain(s) with predicted protein kinase binding activity and role in regulation of cyclin-dependent protein serine/threonine kinase activity CAALFM_C302750WA Protein with a ribonuclease III domain; flow model biofilm induced; Spider biofilm induced CAALFM_C302760CA Protein required for normal filamentous growth; mRNA binds She3 CAALFM_C302770CA Ortholog(s) have role in transcription-coupled nucleotide-excision repair and Ddb1-Ckn1 complex, cytosol localization CAALFM_C302780WA Seryl-tRNA synthetase; charges the tRNA that recognizes the CUG codon, which typically specifies Leu, but specifies Ser in C. albicans; complements S. cerevisiae ses1 mutant viability; soluble protein in hyphae; macrophage-regulated CAALFM_C302790WA Ortholog of C. parapsilosis CDC317 : CPAR2_102150, C. dubliniensis CD36 : Cd36_82780, Pichia stipitis Pignal : psti_CGOB_00155 and Candida orthopsilosis Co 90-125 : CORT_0B03450 CAALFM_C302800WA Predicted 3-hydroxyacyl-CoA dehydrogenase; transcript is increased in azole-resistant strain overexpressing MDR1; transcript is increased in populations of cells exposed to fluconazole over multiple generations; mutant is viable CAALFM_C302810CA Predicted acyl CoA synthetase; upregulated upon phagocytosis; transcript regulated by Nrg1 and Mig1 CAALFM_C302820CA Ortholog(s) have unfolded protein binding activity, role in sterol biosynthetic process and endoplasmic reticulum localization CAALFM_C302830WA Putative RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; induced by Mnl1 under weak acid stress; possibly essential gene, disruptants not obtained by UAU1 method CAALFM_C302840WA Ortholog(s) have RNA binding, ribonuclease MRP activity, ribonuclease P activity CAALFM_C302850CA Plasma membrane-associated protein; upregulated in an azole-resistant strain that overexpresses MDR1; Hap43-repressed; Spider biofilm induced CAALFM_C302860WA Putative thiamin-phosphate pyrophosphorylase, hydroxyethylthiazole kinase; fungal-specific; Spider biofilm induced CAALFM_C302870CA Protein of unknown function; required for adhesion to abiotic substrate; Spider biofilm induced CAALFM_C302880WA Protein with a predicted D-Tyr-tRNA(Tyr) deacylase domain; Hap43-repressed gene CAALFM_C302890CA Ortholog of C. dubliniensis CD36 : Cd36_82875 and Candida albicans WO-1 : CAWG_02609 CAALFM_C302900WA Ortholog of C. dubliniensis CD36 : Cd36_82880, C. parapsilosis CDC317 : CPAR2_102370, Candida tenuis NRRL Y-1498 : CANTEDRAFT_118463 and Pichia stipitis Pignal : PICST_32241 CAALFM_C302910WA Ortholog of C. dubliniensis CD36 : Cd36_82890, Debaryomyces hansenii CBS767 : DEHA2G01034g, Pichia stipitis Pignal : PICST_32242 and Candida guilliermondii ATCC 6260 : PGUG_04638 CAALFM_C302920WA Ortholog of S. cerevisiae Igo2; role in mRNA stabilization of mRNA; Spider biofilm induced CAALFM_C302930WA Has a predicted autophagy-related protein domain; transcription repressed by fluphenazine treatment CAALFM_C302940CA NADH-ubiquinone oxidoreductase subunit; Hap43p-repressed gene; repressed by nitric oxide; identified in detergent-resistant membrane fraction (possible lipid raft component) CAALFM_C302950CA Putative methionine biosynthesis protein; ketoconazole-induced; amphotericin B repressed; Spider biofilm repressed CAALFM_C302960CA UDP-glucose:glycoprotein glucosyltransferase; 1,6-beta-D-glucan biosynthesis, hyphal growth, virulence in mouse IV model; partially complements S. cerevisiae kre5 mutant defects; flow biofilm repressed, Bcr1-repressed in RPMI a/a biofilms CAALFM_C302970CA Ortholog(s) have metalloendopeptidase activity, role in protein sumoylation, response to UV-B, response to UV-C, translesion synthesis and nuclear envelope localization CAALFM_C302980CA Ortholog of C. parapsilosis CDC317 : CPAR2_102390, C. dubliniensis CD36 : Cd36_82960, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133198 and Lodderomyces elongisporus NRLL YB-4239 : LELG_02116 CAALFM_C302990CA Ortholog of C. dubliniensis CD36 : Cd36_82970, Lodderomyces elongisporus NRLL YB-4239 : LELG_02117, Debaryomyces hansenii CBS767 : DEHA2G01012g and Candida lusitaniae ATCC 42720 : CLUG_03529 CAALFM_C303000WA Ortholog of C. dubliniensis CD36 : Cd36_82980, C. parapsilosis CDC317 : CPAR2_102360, Candida tenuis NRRL Y-1498 : cten_CGOB_00165 and Debaryomyces hansenii CBS767 : DEHA2G00990g CAALFM_C303010CA Ortholog(s) have D-leucyl-tRNA(Leu) deacylase activity, D-tyrosyl-tRNA(Tyr) deacylase activity, role in D-leucine catabolic process, D-tyrosine catabolic process, tRNA metabolic process and cytosol, nucleus localization CAALFM_C303020WA Protein of unknown function; flow model biofilm induced CAALFM_C303030CA Ortholog(s) have endoplasmic reticulum, fungal-type vacuole localization CAALFM_C303040WA Putative actin interacting protein; regulated by Gcn4; induced in response to amino acid starvation (3-AT); repressed by elevated CO2; flow model biofilm repressed CAALFM_C303050CA Putative GPI-anchored protein; regulated by Nrg1, Tup1; rat catheter biofilm repressed CAALFM_C303060WA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in ER to Golgi vesicle-mediated transport and TRAPPI protein complex, TRAPPII protein complex, TRAPPIII protein complex, cytosol, nucleus localization CAALFM_C303070WA Putative transporter similar to MDR proteins; fungal-specific; Spider biofilm induced CAALFM_C303080WA Protein of unknown function; upregulated in a cyr1 null mutant CAALFM_C303090WA Kinesin-associated protein; forms heterodimer with Kar3; involved in spindle formation; transcription is induced upon filamentous growth and in response to alpha pheromone in SpiderM medium CAALFM_C303100CA Ortholog(s) have transcription coactivator activity, role in histone acetylation, transcription from RNA polymerase II promoter and Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex localization CAALFM_C303110WA Ortholog(s) have role in nucleobase-containing compound transport and plasma membrane localization CAALFM_C303120CA Allantoate permease; nitrogen catabolite repressed, induced in absence of preferred N sources; nitrogen source regulation requires Gat1; possibly essential gene (by UAU1 method); Hap43-repressed CAALFM_C303130CA Putative mitochondrial protein with a predicted role in cell wall biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C303140CA Putative allantoin permease; fungal-specific (no human or murine homolog) CAALFM_C303150WA Ortholog of S. cerevisiae : STB6, C. dubliniensis CD36 : Cd36_83110, C. parapsilosis CDC317 : CPAR2_103210, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133418 and Debaryomyces hansenii CBS767 : DEHA2G08382g CAALFM_C303160CA Ortholog of C. dubliniensis CD36 : Cd36_83120, C. parapsilosis CDC317 : CPAR2_103220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112860 and Debaryomyces hansenii CBS767 : DEHA2G08360g CAALFM_C303170WA Putative protein transport factor; antigenic during murine systemic infection; macrophage-downregulated protein; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C303180CA Purine nucleoside phosphorylase; metabolizes inosine and guanosine nucleosides; in the nicotinamide riboside salvage pathway; Spider biofilm repressed CAALFM_C303190CA Ortholog(s) have role in iron-sulfur cluster assembly and mitochondrial matrix localization CAALFM_C303200CA Ortholog of S. cerevisiae : YDR286C, C. glabrata CBS138 : CAGL0H01111g, C. dubliniensis CD36 : Cd36_83160, C. parapsilosis CDC317 : CPAR2_101820 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_113333 CAALFM_C303210WA Predicted short chain dehydrogenase; Spider biofilm induced CAALFM_C303230CA Ortholog(s) have L-methionine transmembrane transporter activity and role in methionine import CAALFM_C303250WA Putative haloacid dehalogenase; localized to plasma membrane CAALFM_C303260WA Putative mRNA cleavage and polyadenlylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C303270WA Protein of unknown function; Spider biofilm repressed CAALFM_C303280CA Putative histone H2A; amphotericin B repressed; flucytosine induced; RNA abundance regulated by tyrosol and cell density; Spider biofilm repressed CAALFM_C303290CA Putative urea transporter; induced during infection of murine kidney, compared to growth in vitro; has murine homolog CAALFM_C303300CA Putative pre-mRNA branch point binding protein; role in mRNA splicing via spliceosome; Spider biofilm repressed CAALFM_C303310CA Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, protein methyltransferase activity and role in peptidyl-glutamine methylation, regulation of translation CAALFM_C303320WA Ubiquitin-related protein with similarity to mammalian NEDD8; reversible conjugation (neddylation) of the cullin subunit (Cdc53p) modulates the ubiquitin ligase activity of the SCF complexes CAALFM_C303330CA Member of a complex that contains Prp19; stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; Spider biofilm induced CAALFM_C303340CA Ortholog of C. parapsilosis CDC317 : CPAR2_102640, C. dubliniensis CD36 : Cd36_83290, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98613 and Lodderomyces elongisporus NRLL YB-4239 : LELG_02758 CAALFM_C303360WA Purine-cytosine permease of pyrimidine salvage; mutation associated with resistance to flucytosine in clinical isolates; transposon mutation affects filamentation; farnesol-upregulated in biofilm CAALFM_C303370CA Protein of unknown function; flow model biofilm induced; Spider biofilm induced; regulated by Sef1, Sfu1, and Hap43 CAALFM_C303380WA Sef1p-, Sfu1p-, and Hap43p-regulated gene CAALFM_C303390CA Protein similar to oxidoreductases; induced in high iron; Hap43-repressed CAALFM_C303400CA Ortholog(s) have SNAP receptor activity and role in Golgi to vacuole transport, intra-Golgi vesicle-mediated transport, macroautophagy, vacuole fusion, non-autophagic, vesicle fusion CAALFM_C303410CA Putative glycoside hydrolase; stationary phase enriched protein; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p CAALFM_C303420CA Putative NADH dehydrogenase; may act alternatively to complex I in respiration; caspofungin repressed; rat catheter biofilm induced; Spider biofilm repressed CAALFM_C303430CA Ortholog(s) have role in protein targeting to membrane, protein targeting to vacuole and ESCRT I complex localization CAALFM_C303440CA Putative spermidine export pump; fungal-specific (no human or murine homolog) CAALFM_C303450CA Beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; downregulated in azole-resistant strain; Hap43p-induced CAALFM_C303460CA Protein of unknown function; upregulated by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; transcript possibly regulated by Tac1 CAALFM_C303470WA Succinate semialdehyde dehydrogenase; for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of 4-aminobutyrate and glutamate degradation pathways; rat catheter biofilm induced CAALFM_C303480CA Putative alanine transaminase; mutation confers hypersensitivity to 5-fluorocytosine (5-FC); rat catheter and flow model biofilm induced CAALFM_C303490WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced; induced during the mating process; Hap43-repressed CAALFM_C303500WA Protein with a potential role in beta-1,6 glucan biosynthesis; similarity to Kre6 and Skn1; possibly essential, disruptants not obtained by UAU1 method; Hap43-induced; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C303510CA Ortholog(s) have role in aerobic respiration, mRNA metabolic process and mitochondrial outer membrane localization CAALFM_C303520CA Alpha3 (C9) subunit of the 20S proteasome; transcript regulated by Mig1; flow model biofilm repressed CAALFM_C303530WA Ortholog of S. cerevisiae : YPR153W, C. glabrata CBS138 : CAGL0L08382g, C. dubliniensis CD36 : Cd36_83540, C. parapsilosis CDC317 : CPAR2_404520 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_115795 CAALFM_C303540WA Ortholog of C. dubliniensis CD36 : Cd36_83550, C. parapsilosis CDC317 : CPAR2_404510, Debaryomyces hansenii CBS767 : DEHA2B13794g and Pichia stipitis Pignal : PICST_30078 CAALFM_C303550CA SUMO deconjugation enzyme that cleaves the small ubiquitin-like modifier (SUMO) off proteins CAALFM_C303560WA Ortholog(s) have aminopeptidase activity, role in protein processing, protein stabilization and extrinsic component of mitochondrial inner membrane, nucleus localization CAALFM_C303570CA Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process CAALFM_C303580CA Putative glutathione S-transferase; opaque-specific transcript; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C303590WA Ortholog(s) have role in inner mitochondrial membrane organization, mitochondrion inheritance, mitochondrion morphogenesis, negative regulation of proteolysis, protein folding, replicative cell aging CAALFM_C303600CA Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity, role in glutathione metabolic process and endoplasmic reticulum, mitochondrial outer membrane, plasma membrane localization CAALFM_C303610WA Putative uracil permease CAALFM_C303620CA Protein of unknown function CAALFM_C303630WA Ortholog(s) have mitochondrion localization CAALFM_C303640WA Putative allantoate permease; fungal-specific (no human or murine homolog) CAALFM_C303650WA Essential protein; regulated by hemoglobin; S. cerevisiae ortholog is essential; Hap43p-induced gene CAALFM_C303660WA Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p CAALFM_C303670WA Ortholog(s) have DNA binding, chromatin binding, histone deacetylase activity CAALFM_C303680WA Ortholog(s) have sphinganine-1-phosphate aldolase activity and role in calcium-mediated signaling, cellular response to starvation, sphingolipid metabolic process CAALFM_C303690WA Putative vacuolar membrane transporter for cationic amino acids; Spider biofilm induced CAALFM_C303710WA Manganese transporter; required for normal filamentous growth; mRNA binds She3, localized to hyphal tips; repressed by NO, alkaline pH; colony morphology-related regulation by Ssn6; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced CAALFM_C303720WA Glutathione S-transferase, localized to ER; induced in exponentially growing cells, under oxidative stress; induced by nitric oxide; Spider biofilm induced CAALFM_C303730CA Putative prohibitin; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; Hap43p-repressed gene CAALFM_C303740WA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C303750CA Protein similar to S. cerevisiae Orc3p, which is a component of the origin recognition complex involved in DNA replication; mutation confers hypersensitivity to toxic ergosterol analog; induced under hydroxyurea treatment CAALFM_C303760WA Putative diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol formation; flow model biofilm induced; Spider biofilm induced CAALFM_C303770CA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis CAALFM_C303780WA Protein of unknown function CAALFM_C303790WA Putative methylthioadenosine phosphorylase; protein level decreases in stationary phase cultures CAALFM_C303800WA Oligopeptide transporter involved in uptake of di-/tripeptides; regulated by Stp2 and Stp3; transcript induced upon phagocytosis by macrophage; repressed by Rim101 at pH 8; flow model biofilm induced CAALFM_C303810WA Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of cell cycle checkpoint; ortholog of S. cerevisiae Rad53p, protein kinase required for cell-cycle arrest in response to DNA damage CAALFM_C303820CA Ortholog(s) have role in protein insertion into mitochondrial membrane from inner side and integral component of mitochondrial inner membrane localization CAALFM_C303830WA Ortholog(s) have peptidyl-prolyl cis-trans isomerase activity, protein phosphatase type 2A regulator activity and role in mitotic spindle organization in nucleus, response to osmotic stress CAALFM_C303840CA Putative cleavage factor I subunit; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C303850CA Cell cycle regulator; partial functional homolog of S. cerevisiae Sic1p; protein degradation regulated by SCF(CDC4) pathway; CDK phosphorylation predicted CAALFM_C303860WA Ortholog(s) have acid phosphatase activity, protein tyrosine phosphatase activity, metal-dependent activity and cytosol, nucleus localization CAALFM_C303870CA Secreted aspartyl protease; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; Spider biofilm induced CAALFM_C303880CA Protein similar to S. cerevisiae Pep8p, which is involved in retrograde transport; transposon mutation affects filamentous growth CAALFM_C303890WA Guanyl-nucleotide exchange factor; activator of Ras/adenylyl cyclase pathway; functional homolog of S. cerevisiae Cdc25p; commonly called Cdc25; transposon mutation affects filamentous growth CAALFM_C303900CA Histone H2B; induced by adherence to polystyrene; amphotericin B, caspofungin repressed; flucytosine, fluconazole induced; Efg1 regulated; slow growth, increased white-to opaque switch in ectopic expression strains; Spider biofilm repressed CAALFM_C303910WA Histone H2A; repressed in fkh2 mutant; amphotericin B repressed; farnesol regulated; RNA abundance regulated by tyrosol and cell density; Hap43-induced gene; Spider biofilm repressed CAALFM_C303920WA Ortholog of C. parapsilosis CDC317 : CPAR2_502850, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135869, Debaryomyces hansenii CBS767 : DEHA2F18260g and Pichia stipitis Pignal : psti_CGOB_00119 CAALFM_C303930WA Ortholog(s) have chromatin binding activity, role in RNA polymerase II transcriptional preinitiation complex assembly and transcription factor TFIID complex localization CAALFM_C303980CA Protein of unknown function; Spider biofilm induced CAALFM_C303990CA Putative amino acid permease; fungal-specific; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C304000CA Peroxisomal carnitine acetyl transferase; no obvious metabolic, hyphal, virulence defects in Ura+ strain; induced by macrophage engulfment, hyphal growth, starvation, nonfermentable carbon sources; rat catheter, Spider biofilm induced CAALFM_C304020CA Predicted Zn(II)2Cys6 transcription factor; mutants are viable; rat catheter biofilm induced CAALFM_C304030CA Putative peroxisomal biogenesis factor; expression regulated during planktonic growth CAALFM_C304040WA Ortholog of C. dubliniensis CD36 : Cd36_83980, C. parapsilosis CDC317 : CPAR2_102620, Candida tenuis NRRL Y-1498 : CANTEDRAFT_134550 and Debaryomyces hansenii CBS767 : DEHA2D12100g CAALFM_C304060CA Coproporphyrinogen III oxidase; antigenic; on yeast cell surface, not hyphae; iron-regulated expression; Hap43, macrophage-repressed; farnesol-induced; possibly essential; flow model biofilm induced; rat catheter, Spider biofilm repressed CAALFM_C304070CA Putative transporter of PDR subfamily of ABC family; Gcn4-regulated; induced by Rim101 at pH 8; Spider biofilm induced CAALFM_C304080WA Ortholog of subunit 6 of the ubiquinol cytochrome-c reductase complex, a component of the mitochondrial inner membrane electron transport chain; Hap43-repressed gene CAALFM_C304090WA Similar to RNA binding proteins; downregulated upon adherence to polystyrene; stationary-phase enriched protein CAALFM_C304100WA Has domain(s) with predicted ATP binding, ATPase activity CAALFM_C304110CA Putative component of the MBF transcription complex involved in G1/S cell-cycle progression; non-periodic mRNA expression; predicted, conserved MBF binding sites upstream of G1/S-regulated genes CAALFM_C304120CA Membrane-localized protein of unknown function CAALFM_C304130WA Ortholog of C. dubliniensis CD36 : Cd36_84070, C. parapsilosis CDC317 : CPAR2_102720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98617 and Debaryomyces hansenii CBS767 : DEHA2D07392g CAALFM_C304140CA Nascent polypeptide associated complex protein alpha subunit; soluble protein in hyphae; macrophage/pseudohyphal-induced; protein level decrease in stationary phase cultures; GlcNAc-induced protein; Spider biofilm repressed CAALFM_C304160WA Putative allantoate permease; fungal-specific (no human or murine homolog) CAALFM_C304170WA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C304180WA Protein of beta-1,6-glucan biosynthesis; required for serum-induced hyphal growth; required for efficient utilization of galactose and for growth on glucose; similar to S. cerevisiae Kre9p and Knh1p; O-glycosylated by Pmt1p CAALFM_C304190WA Protein of unknown function; Spider biofilm induced CAALFM_C304200WA Protein related to arginases; downregulated upon adherence to polystyrene; regulated by Gcn2p and Gcn4p CAALFM_C304210WA Ortholog of C. dubliniensis CD36 : Cd36_84160, Candida tenuis NRRL Y-1498 : cten_CGOB_00085, Debaryomyces hansenii CBS767 : DEHA2B08404g and Pichia stipitis Pignal : PICST_67031 CAALFM_C304220CA Protein similar to uridine kinase; repressed by ciclopirox olamine; Spider biofilm induced CAALFM_C304230WA Ortholog(s) have RNA-dependent ATPase activity, role in generation of catalytic spliceosome for first transesterification step, snoRNA splicing and U2-type catalytic step 1 spliceosome localization CAALFM_C304250WA Putative cell wall component; transcript upregulated in cyr1 mutant (yeast or hyphae); Spider and flow model biofilm induced CAALFM_C304260WA Ortholog(s) have role in metal ion transport, protein targeting to vacuole, ubiquitin-dependent protein catabolic process and endoplasmic reticulum, fungal-type vacuole membrane localization CAALFM_C304270CA Putative citrate transport protein; flucytosine induced; amphotericin B repressed, caspofungin repressed; Hap43p-induced gene CAALFM_C304290CA SWI/SNF chromatin remodeling complex subunit involved in transcriptional regulation; mutants have defects in silicone adherence, biofilm formation, hyphal morphogenesis, cell wall defects; increased cell aggregation during yeast form growth CAALFM_C304300CA Putative DNA directed DNA polymerase alpha; RNA abundance regulated by cell cycle, tyrosol and cell density; rat catheter biofilm induced CAALFM_C304310CA Ortholog of C. dubliniensis CD36 : Cd36_84250, C. parapsilosis CDC317 : CPAR2_806160, Candida tenuis NRRL Y-1498 : CANTEDRAFT_137075 and Debaryomyces hansenii CBS767 : DEHA2F11462g CAALFM_C304320WA Predicted syntaxin-like vacuolar t-SNARE, involved in vacuolar inheritance CAALFM_C304330CA Protein of unknown function; Cyr1-repressed; induced by alpha pheromone in SpiderM medium; rat catheter and Spider biofilm induced CAALFM_C304340WA Putative alcohol acetyltransferase; caspofungin repressed; expression depends on Tac1p CAALFM_C304350CA Has domain(s) with predicted oxidoreductase activity and role in metabolic process CAALFM_C304360WA Putative voltage-gated chloride channel; predicted role in copper ion and iron ion homeostasis; flow model biofilm induced CAALFM_C304370CA Putative nucleolar preribosomal-associated protein; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1; Spider biofilm induced CAALFM_C304380CA Putative U3 snoRNP protein; flucytosine induced CAALFM_C304390WA Putative proteolipid subunit of the vacuolar H(+)-ATPase V0 sector; required for vacuolar acidification, secretion, filamentous growth; caspofungin repressed CAALFM_C304400CA Ortholog of S. cerevisiae Nup85; a structural constituent of the nuclear pore; required for alkaline-induced hyphal morphogenesis and for SD or Spider media biofilm formation CAALFM_C304410CA Ortholog of C. dubliniensis CD36 : Cd36_84350, C. parapsilosis CDC317 : CPAR2_806070, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133308 and Debaryomyces hansenii CBS767 : DEHA2F11682g CAALFM_C304420WA Ortholog of S. cerevisiae Hul4; similar to hect domain E3 ubiquitin-protein ligases; Hap43-repressed gene CAALFM_C304430WA Putative ubiquinol cytochrome c-reductase; induced by high iron; Hap43, nitric oxide, alkaline repressed; Spider biofilm repressed CAALFM_C304440CA Ortholog of S. cerevisiae : YEL023C, C. glabrata CBS138 : CAGL0I03168g, C. dubliniensis CD36 : Cd36_84380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_101635 and Pichia stipitis Pignal : PICST_19384 CAALFM_C304450CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C304460WA Ortholog(s) have role in positive regulation of TORC1 signaling and Seh1-associated complex, cytosol, extrinsic component of fungal-type vacuolar membrane localization CAALFM_C304470WA Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated CAALFM_C304480CA Protein similar to S. cerevisiae Ras2; has opposite effects to Ras1; Tn mutation affects filamentous growth; rat catheter and Spider biofilm induced CAALFM_C304490WA Protein with a predicted role in bud site selection; hypha-induced expression; Spider biofilm induced CAALFM_C304500CA Ribosomal protein L19; repressed upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed CAALFM_C304510WA Protein of unknown function; Hap43-induced; F-12/CO2 early biofilm induced CAALFM_C304520CA Phosphoribosylaminoimadazole carboxylase; role in adenine biosynthesis; required for normal growth and virulence in immunosuppressed mouse infection; not induced in GCN response, in contrast to S. cerevisiae ADE2; stationary phase-enriched CAALFM_C304530CA TEA/ATTS transcription factor; white cell pheromone response, hyphal gene regulation; required for Spider and RPMI biofilm formation; regulates BCR1; Cph2 regulated transcript; alkaline, rat catheter, Spider, flow model biofilm induced CAALFM_C304540CA Putative histone acetyltransferase complex subunit; induced upon low-level peroxide stress; Spider biofilm induced CAALFM_C304550CA Putative calcium/calmodulin-dependent protein kinase II; expression regulated upon white-opaque switching; biochemically purified Ca2+/CaM-dependent kinase is soluble, cytosolic, monomeric, and serine-autophosphorylated; Hap43p-repressed CAALFM_C304560WA Putative 66S pre-ribosomal particle subunit; mutation confers hypersensitivity to tubercidin (7-deazaadenosine) CAALFM_C304570CA Putative urea transporter CAALFM_C304580CA Transcription factor; regulates SAP2, OPT1 expression and thereby protein catabolism for nitrogen source; activated via amino-acid-induced proteolytic processing; macrophage/pseudohyphal-repressed; Spider biofilm repressed CAALFM_C304590WA RNA binding protein required for export of poly(A)+ mRNA from the nucleus; Spider biofilm repressed CAALFM_C304610WA Protein similar to A. nidulans MesA, which is involved in localization of actin cables; Hap43p-induced gene CAALFM_C304620CA Ortholog of C. dubliniensis CD36 : Cd36_84570, C. parapsilosis CDC317 : CPAR2_404420, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115339 and Debaryomyces hansenii CBS767 : DEHA2G13618g CAALFM_C304630WA Ortholog(s) have glyoxysome localization CAALFM_C304640WA Zn(II)2Cys6 transcription factor of unknown function; mutant is sensitive to copper and SDS, and resistant to Calcofluor White; required for yeast cell adherence to silicone substrate CAALFM_C304650WA Ortholog of S. cerevisiae : AIM6, C. glabrata CBS138 : CAGL0C05533g, C. dubliniensis CD36 : Cd36_84610, C. parapsilosis CDC317 : CPAR2_404550 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_115337 CAALFM_C304660CA Putative ornithine transporter of the mitochondrial inner membrane; induced during the mating process CAALFM_C304670CA Putative ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C304680WA Conserved acidic ribosomal protein; possibly involved in regulation of translation elongation; interacts with Rpp1A; 1 of 4 similar C. albicans proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); macrophage/pseudohyphal-induced; Spider biofilm repressed CAALFM_C304690CA Putative protein of unknown function, transcription is positively regulated by Tbf1p CAALFM_C304700WA Ortholog(s) have nucleocytoplasmic transporter activity, structural constituent of nuclear pore activity CAALFM_C304710WA Lipid transporter involved in sterol trafficking and transport of glycosylphosphatidylinositol and sphingolipid precursors CAALFM_C304720CA Protein of unknown function; Spider biofilm induced CAALFM_C304730CA Protein of unknown function; transcript induced by benomyl treatment CAALFM_C304740CA Ortholog(s) have DNA topoisomerase type I activity CAALFM_C304750WA Ortholog of C. dubliniensis CD36 : Cd36_84710, C. parapsilosis CDC317 : CPAR2_807470, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136475 and Debaryomyces hansenii CBS767 : DEHA2B08844g CAALFM_C304760CA Putative helicase; repressed by prostaglandins CAALFM_C304770CA Predicted Zn(II)2Cys6 transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed CAALFM_C304780CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and ER to Golgi transport vesicle, integral component of Golgi membrane, integral component of endoplasmic reticulum membrane localization CAALFM_C304790WA Zinc finger protein orthologous to S. cerevisiae Itt1; repressed by adherence to polystyrene; Spider biofilm induced CAALFM_C304800CA Ortholog(s) have role in peroxisome organization and peroxisomal membrane localization CAALFM_C304810CA Protein of unknown function; transcript upregulated in an RHE model of oral candidiasis; rat catheter and Spider biofilm repressed CAALFM_C304820CA Putative guanine nucleotide exchange factor (GEF); mutation confers hypersensitivity to Brefeldin A; caspofungin repressed CAALFM_C304830CA Alpha subunit of fatty-acid synthase; required for virulence in mouse systemic infection and rat oropharyngeal infection models; regulated by Efg1; fluconazole-induced; amphotericin B repressed; flow model and Spider biofilm repressed CAALFM_C304840CA Protein of unknown function; induced by nitric oxide independent of Yhb1; Sef1, Sfu1, and Hap43-induced; rat catheter and Spider biofilm induced CAALFM_C304860WA C2H2 transcription factor involved in regulation of biofilm formation; rat catheter biofilm induced CAALFM_C304870WA Ortholog(s) have enzyme activator activity and role in ascospore wall assembly, meiotic DNA integrity checkpoint, positive regulation of protein catabolic process, proteolysis, synaptonemal complex assembly CAALFM_C304880WA Putative SH3-domain-containing protein; predicted role in actin cytoskeleton organization; Spider biofilm repressed CAALFM_C304890WA Multidrug transporter, ATP-binding cassette (ABC) superfamily; transports phospholipids, in-to-out direction; overexpressed in azole-resistant isolates; repressed in young biofilms CAALFM_C304900WA Putative nucleolar protein; Hap43-induced; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); heterozygous mutant is resistant to parnafungin; Spider biofilm induced CAALFM_C304910CA Non classical protein export protein; localized to plasma membrane; Hap43-induced gene; flow model biofilm induced; Spider biofilm induced CAALFM_C304920CA Ortholog(s) have role in proteasome regulatory particle assembly, proteolysis and cytosol, nucleus, proteasome regulatory particle localization CAALFM_C304930CA Glucose and galactose sensor; fermentation, filamentation, virulence roles; 20-member glucose transporter family; extended C terminus; high-glucose repressed; macrophage induced; flow model biofilm repressed; Spider biofilm induced CAALFM_C304940WA Putative prenyltransferase; essential gene in S. cerevisiae; Spider biofilm induced CAALFM_C304950WA Putative ADP-ribosylation factor; mutation confers hypersensitivity to Brefeldin A; Spider biofilm repressed CAALFM_C304960WA Ribosomal protein; downregulation correlates with clinical development of fluconazole resistance; colony morphology-related gene regulation by Ssn6; Hap43-induced; Spider biofilm repressed CAALFM_C304970CA Ortholog(s) have ubiquitin-ubiquitin ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process, cellular response to ethanol, protein ubiquitination and cytoplasm, nucleus localization CAALFM_C304990WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C305000WA Putative rho GDP dissociation inhibitor; transposon mutation affects filamentous growth; farnesol, filament-induced; regulated by Nrg1, Tup1; protein levels low in stationary phase yeast CAALFM_C305010CA Putative DNA repair helicase; transcriptionally induced by interaction with macrophage; fungal-specific (no human or murine homolog) CAALFM_C305020WA Ortholog of S. cerevisiae : MTC6, C. glabrata CBS138 : CAGL0I01892g, C. dubliniensis CD36 : Cd36_84990, C. parapsilosis CDC317 : CPAR2_405620 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_99433 CAALFM_C305030WA Prohibitin 2; plasma membrane localized CAALFM_C305040CA Protein similar to S. cerevisiae Atg9; required for early step in autophagy; required for cytoplasm to vacuole trafficking of Lap41; Spider biofilm induced CAALFM_C305050WA C2H2 transcription factor; fluconazole-repressed; induced in ssr1 mutant; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C305060WA Protein of unknown function; ortholog of S. cerevisiae Urn1; downregulated by fluphenazine treatment, in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1 CAALFM_C305070WA Protein similar to S. cerevisiae Cem1p, an acyl carrier protein involved in fatty acid biosynthesis; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C305080WA Has domain(s) with predicted oxidoreductase activity, transferase activity, transferring acyl groups other than amino-acyl groups, zinc ion binding activity and role in oxidation-reduction process CAALFM_C305090CA Protein of unknown function; Hap43-repressed gene CAALFM_C305100CA Predicted ribosomal protein; Plc1p-regulated, Tbf1-activated; repressed upon phagocytosis by murine macrophage; Hap43p-induced; Spider biofilm repressed CAALFM_C305110WA Putative protein of unknown function; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media CAALFM_C305120CA Ortholog(s) have tubulin binding activity, role in response to cold, tubulin complex assembly and cytosol, nucleus, polysome, prefoldin complex localization CAALFM_C305130CA Thiamine biosynthetic enzyme precursor; repressed during the mating process; stationary phase enriched protein; Spider biofilm induced CAALFM_C305140CA Ortholog(s) have tRNA (guanine-N2-)-methyltransferase activity, role in tRNA methylation and cytosol, nucleus, tRNA (m2G10) methyltransferase complex localization CAALFM_C305150WA Putative cleavage factor I subunit; required for the cleavage and polyadenylation of pre-mRNA 3' ends; Spider biofilm repressed CAALFM_C305160CA Ortholog(s) have role in assembly of large subunit precursor of preribosome, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C305170WA Zn(II)2Cys6 transcription factor; regulator of white-opaque switching; required for maintenance of opaque state; Hap43-induced CAALFM_C305180WA Putative small G protein from the Ras superfamily involved in cell wall integrity and control of filamentous growth under nitrogen starvation CAALFM_C305190CA Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon H2O2 treatment; fungal-specific (no human or murine homolog); farnesol-induced CAALFM_C305200WA Putative ribosomal protein S19; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C305210CA Dynein heavy chain; motor protein that moves to microtubule minus end; required for yeast cell separation, spindle positioning, nuclear migration, hyphal growth; regulated by Mig1, Hap43; flow model and rat catheter biofilm repressed CAALFM_C305220WA Multidrug transporter of ABC superfamily; transports phospholipids in an in-to-out direction; induced by beta-estradiol, progesterone, corticosteroid, or cholesterol; Spider biofilm induced CAALFM_C305230WA Secreted aspartyl proteinase, acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase; produced by opaque phase cells; alpha-pheromone repressed CAALFM_C305240CA Predicted ribosomal protein; regulated upon yeast-hypha switch; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C305250CA Protein of unknown function; role in intracellular signal transduction; Spider biofilm induced CAALFM_C305270CA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended N terminus; expressed in rich medium; Hap43p-repressed CAALFM_C305280CA Predicted fatty acid acyl transferase-related protein domain; repressed by prostaglandins CAALFM_C305290CA S. cerevisiae ortholog YLL032C interacts with ribosomes; repressed by alpha pheromone in SpiderM medium CAALFM_C305300CA Ortholog(s) have choline kinase activity, ethanolamine kinase activity, role in phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process and cytosol, nucleus localization CAALFM_C305310WA Putative vesicular transport protein; transcript induced by filamentous growth; rat catheter biofilm repressed CAALFM_C305320WA Protein of unknown function; Hog1-repressed; Spider biofilm induced CAALFM_C305330CA Ortholog of C. dubliniensis CD36 : Cd36_85310, C. parapsilosis CDC317 : CPAR2_807370, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115544 and Debaryomyces hansenii CBS767 : DEHA2D11770g CAALFM_C305340WA Ortholog(s) have dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity, role in protein N-linked glycosylation and endoplasmic reticulum membrane localization CAALFM_C305350CA Putative cell wall assembly regulatory protein; Rim101-repressed; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C305360CA ATP-dependent LON protease family member; Hap43-repressed gene; regulated by Gcn2 and Gcn4; Spider biofilm induced CAALFM_C305370CA Ribosome-associated protein; antigenic in mice; complements S. cerevisiae yst1 yst2 mutant; similar to laminin receptor; predicted S/T phosphorylation, N-glycosylation, myristoylation, Hap43-, Gcn4-regulated; Spider biofilm repressed CAALFM_C305380WA Predicted MFS membrane transporter; member of the proton coupled folate transporter/heme carrier protein family; virulence-group-correlated expression; Spider biofilm induced CAALFM_C305390CA Putative protein of GPI synthesis; expression is reduced in a fluconazole-resistant isolate CAALFM_C305400CA Planktonic growth-induced gene CAALFM_C305410WA Ortholog(s) have role in cellular manganese ion homeostasis, mitochondrion organization and fungal-type vacuole membrane localization CAALFM_C305420WA Has domain(s) with predicted ATP binding, protein kinase activity, protein tyrosine kinase activity and role in protein phosphorylation CAALFM_C305430WA Ortholog of S. cerevisiae : YKR051W, C. glabrata CBS138 : CAGL0K08228g, C. dubliniensis CD36 : Cd36_85420, C. parapsilosis CDC317 : CPAR2_405720 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_124861 CAALFM_C305440CA Ortholog(s) have ribosome binding activity, role in mitochondrial translational initiation and mitochondrion localization CAALFM_C305450CA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide; Spider biofilm induced CAALFM_C305460WA Ortholog of C. dubliniensis CD36 : Cd36_85460, C. parapsilosis CDC317 : CPAR2_405760, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116052 and Debaryomyces hansenii CBS767 : DEHA2D16940g CAALFM_C305470WA Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Tea1p; Hap43p-repressed gene CAALFM_C305510WA Has domain(s) with predicted intracellular localization CAALFM_C305520CA Putative dynamin-related GTPase; transcript upregulated inbRHE model of oral candidiasis; transcript regulated by Nrg1, Mig1, and Tup1 CAALFM_C305530WA Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins; Spider biofilm repressed CAALFM_C305540CA Putative U2 snRNP-associated protein; Spider biofilm induced CAALFM_C305550CA Putative peptidyl-prolyl cis-trans isomerase; predicted endoplasmic reticulum (ER) localization CAALFM_C305560WA Putative beta-1 proteasome subunit; macrophage-induced protein; regulated by Gcn2p and Gcn4p; GlcNAc-induced protein CAALFM_C305570WA Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced CAALFM_C305580CA General amino acid permease; ketoconazole, flucytosine repressed; Ssy1-dependent histidine induction; regulated by Nrg1, Tup1; colony morphology-related gene regulation by Ssn6; Spider and flow model biofilm induced CAALFM_C305590CA Putative branched chain amino acid aminotransferase; regulated by Gcn4p; induced by farnesol treatment, GlcNAc, amino acid starvation (3-aminotriazole treatment); present in exponential and stationary growth phase yeast cultures CAALFM_C305600WA Putative fungal-specific transmembrane protein CAALFM_C305610WA Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation; Hap43-repressed; Spider biofilm induced CAALFM_C305620WA Putative fungal-specific transmembrane protein CAALFM_C305630WA Putative glutathione S-transferase; downregulated upon adherence to polystyrene; regulated upon white-opaque switching; induced in the presence of human neutrophils; oxidative stress-induced via Cap1p; regulated by Gcn2p, Gcn4p CAALFM_C305640WA Predicted oxidoreductase; rat catheter biofilm repressed CAALFM_C305650WA Plasma membrane protein similar to S. cerevisiae casein kinase I, Yck2p; null mutant has defect in damaging oral epithelial cells and in hyphal branching; transcription is activated in weak acid stress or on contact with host cells CAALFM_C305660CA Ortholog of C. parapsilosis CDC317 : CPAR2_806990, Candida tenuis NRRL Y-1498 : CANTEDRAFT_122709, Debaryomyces hansenii CBS767 : DEHA2E00110g and Pichia stipitis Pignal : PICST_30109 CAALFM_C305680WA Ortholog(s) have ubiquitin-protein transferase activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination and endoplasmic reticulum membrane localization CAALFM_C305700WA Activator of Chs3p chitin synthase; required for wild-type wall chitin content, but not for hyphal growth; mutant resistant to Calcofluor white; prenylation and 2 transmembrane segments predicted; functional homolog of S. cerevisiae Chs4p CAALFM_C305710WA Fluconazole-induced protein; Ras1, Cyr1 repressed and Efg1 induced; regulated by Nrg1, Tup1, Tbf1, Ssn6; induced in oralpharyngeal candidasis; rat catheter biofilm repressed CAALFM_C305720CA Putative kinesin, involved in mitotic spindle organization CAALFM_C305730CA Ceramide synthase; required for biosynthesis of ceramides with C18:0 fatty acids, which serve as precursors for glucosylsphingolipids; caspofungin induced CAALFM_C305740CA Ortholog of S. cerevisiae Ssn8; a component of RNA polymerase II holoenzyme; mutants are viable and are sensitive to hydrogen peroxide medium CAALFM_C305750CA Ortholog of C. parapsilosis CDC317 : CPAR2_807080, C. dubliniensis CD36 : Cd36_85690, Candida orthopsilosis Co 90-125 : CORT_0C02090 and Candida albicans WO-1 : CAWG_02885 CAALFM_C305760WA Ortholog(s) have phosphopantothenate--cysteine ligase activity, role in acetyl-CoA biosynthetic process from pantothenate, coenzyme A biosynthetic process and CoA-synthesizing protein complex, cytosol, nucleus localization CAALFM_C305770CA Predicted component of the SAM complex involved in mitochondrial protein import CAALFM_C305780CA Calcineurin-regulated C2H2 transcription factor; role in maintenance of membrane integrity, azole tolerance; not required for mouse virulence; repressed by low iron; regulates Ca++ influx during alkaline pH response; Spider biofilm induced CAALFM_C305790CA Ortholog(s) have enzyme activator activity, role in histone deubiquitination, regulation of transcription from RNA polymerase II promoter and DUBm complex, SAGA complex localization CAALFM_C305800WA Ortholog(s) have tRNA-intron endonuclease activity, role in tRNA-type intron splice site recognition and cleavage and mitochondrial outer membrane, tRNA-intron endonuclease complex localization CAALFM_C305810CA Protein with a role in beta-1,6-glucan synthesis; probable N-glycosylated type II membrane protein; transcript and mRNA length change induced by yeast-hypha transition; induced by Rim101, caspofungin; rat catheter and Spider biofilm induced CAALFM_C305830WA Essential beta-1,6-glucan synthase subunit; change in mRNA length, not abundance, at yeast-hypha transition; alkaline induced by Rim101, on cell wall regeneration; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms CAALFM_C305840WA Has domain(s) with predicted N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding activity and role in oxidation-reduction process CAALFM_C305850WA Ortholog(s) have ubiquitin-protein transferase activity and role in negative regulation of apoptotic process, negative regulation of gluconeogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process CAALFM_C305860CA Ortholog(s) have rRNA (uridine-N3-)-methyltransferase activity, role in rRNA base methylation and nucleolus localization CAALFM_C305870CA Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and endoplasmic reticulum localization CAALFM_C305880CA Ortholog(s) have mRNA binding, poly(U) RNA binding activity and role in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA stability, stress granule assembly CAALFM_C305890WA Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups activity and role in tRNA methylation, wybutosine biosynthetic process CAALFM_C305900WA Possible G-protein coupled receptor; vacuolar membrane transporter for cationic amino acids; PQ-loop motif; rat catheter and Spider biofilm induced CAALFM_C305910WA Zn(II)2Cys6 transcription factor; Hap43-induced; Spider biofilm induced CAALFM_C305920WA Putative Zn(II)2Cys6 transcription factor; regulator of MDR1 transcription; gain-of-function mutations cause upregulation of MDR1 (a plasma membrane multidrug efflux pump) and multidrug resistance; Hap43-induced CAALFM_C305930WA Zn(II)2Cys6 transcription factor; induced by nitric oxide; induced by Mnl1 under weak acid stress; repressed upon adherence to polystyrene; Hap43-repressed; Spider biofilm induced CAALFM_C305940CA Putative U1A component of the U1 snRNP, involved in splicing; contains two RNA recognition motifs (RRMs); ortholog of S. cerevisiae MUD1 CAALFM_C305950WA Ortholog of C. dubliniensis CD36 : Cd36_85880, C. parapsilosis CDC317 : CPAR2_806870, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96983 and Debaryomyces hansenii CBS767 : DEHA2D16148g CAALFM_C305960WA Putative microtubule-associated protein; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase CAALFM_C305970CA Ortholog(s) have phosphopantothenoylcysteine decarboxylase activity, protein phosphatase inhibitor activity and role in regulation of mitotic cell cycle, response to salt stress CAALFM_C305980CA Putative acyl CoA synthetase; expression regulated upon white-opaque switch; rat catheter biofilm induced; Spider biofilm induced CAALFM_C305990CA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_C306000WA Zn(II)2Cys6 transcription factor; involved in regulation of adhesion genes; involved in white-opaque switch; forms complex with Mcm1; mutant is sensetive to 5-fluorocytosine and lithium chloride; Spider biofilm induced CAALFM_C306010WA Putative translation elongation factor eEF1 gamma; protein level decreased in stationary phase cultures; Spider biofilm repressed CAALFM_C306020WA Protein of N-linked outer-chain mannan biosynthesis; mutant has defective cell wall; required for wild-type hyphal growth; mutant is hygromycin B sensitive and vanadate resistant; has N-terminal membrane-spanning segment (positions 18-34) CAALFM_C306030WA Putative GTPase; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); repressed by prostaglandins; Hap43-induced CAALFM_C306040WA CCCH zinc finger protein; Spider biofilm induced CAALFM_C306050CA Ortholog(s) have ribosome binding activity CAALFM_C306060WA Predicted histone acetyltransferase; role in regulation of transcription, tRNA wobble uridine modification; Spider biofilm induced CAALFM_C306070CA MAPK kinase (MAPKK); role in osmotic and oxidative stress responses, oxidative stress adaptation; required for stress regulation of Hog1p localization and activity; functional homolog of S. cerevisiae Pbs2p CAALFM_C306080WA Ortholog(s) have DNA-directed DNA polymerase activity, role in error-free translesion synthesis, error-prone translesion synthesis and cytosol, mitochondrion, nuclear chromatin, nucleus, zeta DNA polymerase complex localization CAALFM_C306090CA Alpha-1,6-mannosyltransferase; initiates N-glycan outer chain branch addition; similar to S. cerevisiae Och1p; required for wild-type virulence in mouse intravenous infection; fungal-specific (no human or murine homolog) CAALFM_C306100CA Predicted ATP-dependent RNA helicase; RNA strand annealing activity; Spider biofilm induced CAALFM_C306110CA Predicted NAD+/NADH kinase; possible role in cellular iron ion homeostasis; Spider biofilm induced CAALFM_C306120CA Golgi membrane GDPase, required for wild-type O-mannosylation, not N-glycosylation; required for wild-type hyphal induction, cell wall, and cell surface charge; not required for HeLa cell adherence; functional homolog of S. cerevisiae Gda1p CAALFM_C306140WA Protein of unknown function; Spider biofilm induced; Hap43-repressed CAALFM_C306150WA Ortholog(s) have sequence-specific DNA binding activity CAALFM_C306160CA Predicted ORF identical to NSA2 CAALFM_C306170CA Predicted ORF identical to orf19.7420 CAALFM_C306180CA TSA/alkyl hydroperoxide peroxidase C (AhPC) family protein; similar to thiol-dependent peroxidases of oxidative stress signaling; antigenic; hyphal surface, nucleus; yeast-form nucleus, cytoplasm; biofilm, phagocytosis, peroxide induced CAALFM_C306190CA ALS family protein; expression in S. cerevisiae confers adhesion to gelatin; macrophage-induced gene; N-terminal adhesion domain; ALS family includes cell-surface glycoproteins, some with adhesin function CAALFM_C306200CA Putative MMS21-SMC5-SMC6 complex component CAALFM_C306210CA Predicted protein required for ubiquitination; role in meiosis, regulation of cell budding in S. cereviae; Spider biofilm induced CAALFM_C306220CA Putative mitochondrial inner membrane transporter; rat catheter biofilm induced CAALFM_C306230WA Putative metalloprotease of the mitochondrial intermembrane space; rat catheter biofilm induced CAALFM_C306240CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C306250WA Component of COPII-coated vesicles; transcript induced upon filamentous growth; rat catheter biofilm repressed CAALFM_C306260CA Ortholog of C. dubliniensis CD36 : Cd36_86220, C. parapsilosis CDC317 : CPAR2_404490, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94473 and Debaryomyces hansenii CBS767 : DEHA2D01804g CAALFM_C306270CA Ortholog of Rad33; involved in nucleotide excision repair in S. cerevisiae; induced by Mnl1 under weak acid stress CAALFM_C306280WA Catabolic L-serine (L-threonine) deaminase;, catalyzes degradation of L-serine and L-threonine; required to use serine or threonine as a sole nitrogen source; Spider biofilm repressed CAALFM_C306290WA Ortholog of S. cerevisiae : YML020W, C. glabrata CBS138 : CAGL0J10538g, C. dubliniensis CD36 : Cd36_86190, C. parapsilosis CDC317 : CPAR2_404740 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_107670 CAALFM_C306300WA Putative modulator of white-opaque switching CAALFM_C306310CA Ortholog of S. cerevisiae Isw2; an ATPase involved in chromatin remodeling; required for chlamydospore formation; Hap43-induced gene; repressed by high-level peroxide stress CAALFM_C306320WA ALS family protein; hypermutable contingency gene; growth-regulated, downregulated in biofilm; two variable repeat regions; expression in S. cerevisiae does not confer adhesiveness; ALS family includes adhesins, cell-surface glycoproteins CAALFM_C306330WA Putative peroxidase; orf19.7398.1 is contig-truncated fragment of gene identical to TSA1; Tsa1p and Tsa1Bp role under oxidative/reductive stress, hyphal cell wall formation; in hyphal nucleus, cell wall; yeast-form nucleus, cytoplasm CAALFM_C306340WA Putative dinucleoside triphosphate hydrolase; induced upon low-level peroxide stress CAALFM_C306350WA Ortholog(s) have RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly activity CAALFM_C306360CA Putative peptidyl-prolyl cis-trans isomerase; macrophage-downregulated protein level; protein level decrease in stationary phase cultures; predicted endoplasmic reticulum (ER) localization CAALFM_C306370CA Ortholog(s) have role in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C306380WA Putative protein constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins CAALFM_C306390WA Protein of unknown function' Hap43-induced gene; repressed by prostaglandins CAALFM_C306400CA Ortholog(s) have uracil DNA N-glycosylase activity, role in DNA repair and mitochondrion, nucleus localization CAALFM_C306410CA Ortholog(s) have role in protein N-linked glycosylation via asparagine, protein complex assembly and oligosaccharyltransferase complex localization CAALFM_C306420CA Ortholog(s) have Golgi apparatus, fungal-type vacuole membrane localization CAALFM_C306430WA Ortholog of S. cerevisiae Apn1; an AP endonuclease; transcript induced by interaction with macrophages; fungal-specific (no human or murine homolog) CAALFM_C306440WA Ortholog(s) have nucleocytoplasmic transporter activity, structural constituent of nuclear pore activity CAALFM_C306450WA Putative self-glucosylating initiator of glycogen synthesis; expression regulated upon white-opaque switch; hypha-induced; Spider biofilm induced CAALFM_C306470WA Possible regulatory protein; possible adhesin-like; Glu-rich domain; production in S. cerevisiae increases endothelial cell adherence and flocculence; flow model biofilm, alkaline or caspofungin induced CAALFM_C306480CA Protein of unknown function; predicted role in cell wall organization; Hap43-repressed; caspofungin repressed; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C306490WA Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YJL218W CAALFM_C306500WA Ubiquitin-activating enzyme; protein level decreases in stationary phase cultures CAALFM_C306510CA ABC transporter related to mammalian P-glycoproteins; functional homolog of S. cerevisiae Ste6p (a-pheromone transporter); required for mating of MTLa cells; a-type specific, not regulated during white-opaque or yeast-hyphal switching CAALFM_C306520CA Ortholog(s) have role in cellular lipid metabolic process, nuclear envelope organization and nuclear envelope localization CAALFM_C306530WA Ortholog of C. dubliniensis CD36 : Cd36_86500, C. parapsilosis CDC317 : CPAR2_206120, Candida tenuis NRRL Y-1498 : CANTEDRAFT_100862 and Debaryomyces hansenii CBS767 : DEHA2F17270g CAALFM_C306540CA Ortholog of C. dubliniensis CD36 : Cd36_86510, C. parapsilosis CDC317 : CPAR2_206110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112184 and Debaryomyces hansenii CBS767 : DEHA2F17292g CAALFM_C306550CA Ortholog(s) have cytoplasm, holo TFIIH complex localization CAALFM_C306560WA Ortholog of S.c. Vid24; a peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced CAALFM_C306570CA Phosphatidylethanolamine N-methyltransferase; phosphatidylcholine biosynthesis; downregulation correlates with clinical development of fluconazole resistance; amphotericin B, caspofungin repressed; Hap43-induced; Spider biofilm repressed CAALFM_C306580WA Lactate transporter; induced by lactic acid, activated by Cat8; alkaline repressed by Rim101; localizes to plasma membrane; Spider biofilm induced CAALFM_C306590WA Saccharopine dehydrogenase; lysine biosynthesis; soluble protein in hyphae; amphotericin B repressed; Gcn4-regulated; colony morphology-related gene regulation by Ssn6; protein present in exponential and stationary growth phase yeast CAALFM_C306600CA Ortholog(s) have role in mitochondrial genome maintenance, plasmid maintenance and cytosol, mitochondrion localization CAALFM_C306610WA Ortholog(s) have protein binding, bridging activity, role in septin ring assembly and cellular bud neck septin ring localization CAALFM_C306620WA Putative PAS kinase involved in cell wall damage response; similar to S. cerevisiae Psk1p, a putative serine/threonine protein kinase; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced CAALFM_C306630WA Ortholog(s) have chromatin binding activity and role in DNA replication initiation, DNA unwinding involved in DNA replication, double-strand break repair via break-induced replication CAALFM_C306640WA Ortholog of Candida albicans WO-1 : CAWG_02974 CAALFM_C306650CA Putative TFIID and SAGA complex subunit; mutation confers hypersensitivity to amphotericin B CAALFM_C306660CA Ortholog of C. dubliniensis CD36 : Cd36_86630 and Candida tropicalis MYA-3404 : CTRG_05698 CAALFM_C306670CA Protein of unknown function; flow model biofilm repressed CAALFM_C306680CA Protein with Mob2p-dependent hyphal regulation CAALFM_C306690CA Ortholog of C. dubliniensis CD36 : Cd36_86660, Candida tenuis NRRL Y-1498 : cten_CGOB_00028, Candida tropicalis MYA-3404 : CTRG_05695 and Candida albicans WO-1 : CAWG_02979 CAALFM_C306700CA Putative mitochondrial protein with a predicted role in respiratory growth; fluconazole-induced; ketoconazole-repressed; mutants display a strong defect in flow model biofilm formation; Spider biofilm induced CAALFM_C306710WA Protein of unknown function; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C306720WA Putative pre-mRNA processing RNA-helicase; induced upon adherence to polystyrene; rat catheter and Spider biofilm induced CAALFM_C306730WA Putative enoyl-CoA hydratase; Spider biofilm induced CAALFM_C306740WA Protein with a predicted mitochondrial ATPase expression domain; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C306750WA Ortholog(s) have P-P-bond-hydrolysis-driven protein transmembrane transporter activity, protein transporter activity, structural molecule activity CAALFM_C306760WA Ortholog(s) have role in rRNA processing and nucleolus, preribosome, large subunit precursor localization CAALFM_C306770WA Protein similar to S. cerevisiae RNA splicing factor, Slu7; induced by alpha pheromone in SpiderM medium CAALFM_C306780CA Putative polysome-associated RNA binding protein; macrophage-induced gene CAALFM_C306790WA Helix-loop-helix transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate; Spider and F-12/CO2 biofilm induced; repressed by alpha pheromone in SpiderM medium CAALFM_C306800CA Ortholog(s) have NEDD8 transferase activity, cullin family protein binding, protein binding, bridging, ubiquitin binding, ubiquitin conjugating enzyme binding activity CAALFM_C306810WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_C306820CA Has domain(s) with predicted protein heterodimerization activity, role in DNA-templated transcription, initiation and transcription factor TFIID complex localization CAALFM_C306830CA Ortholog(s) have mRNA binding activity and cytosol, mitochondrion localization CAALFM_C306850WA Transcription factor; repressor of fluconazole/ketoconazole/brefeldin A resistance; Tn mutation enhances filamentation; partially rescues S. cerevisiae pdr1 pdr3 fluconazole sensitivity; rat catheter biofilm induced/Spider biofilm repressed CAALFM_C306860CA Putative xylose and arabinose reductase; flow model biofilm induced; Spider biofilm repressed CAALFM_C306870WA NAD-linked glyceraldehyde-3-phosphate dehydrogenase; binds fibronectin, laminin; at cell surface; antigenic in infection; farnesol-repressed; stationary phase-enriched; GlcNAc-induced; flow model biofilm induced; Spider biofilm repressed CAALFM_C306880WA Protein of unknown function; Hap43-induced gene CAALFM_C306890WA Protein mannosyltransferase (PMT) with roles in hyphal growth and drug sensitivity; member of the PMT family which includes Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p; induced during cell wall regeneration; essential CAALFM_C306900WA Protein required for maturation of mitochondrial [4Fe-4S] proteins; role in biotin biosynthetic process; rat catheter and Spider biofilm induced CAALFM_C306910CA Subunit of protein serine/threonine phosphatase PPA2, involved in regulation of cytokinesis and morphogenesis; forms complex with catalytic subunit Pph21p that dephosphorylates septin Sep7p CAALFM_C306920WA Putative phosphomutase-like protein; protein present in exponential and stationary growth phase yeast; Hap43-repressed; Spider biofilm repressed CAALFM_C306940WA Predicted ORF in retrotransposon Tca17 with similarity to parts of the Gag-Pol region of retrotransposons; clade-associated gene expression CAALFM_C306950WA Protein of unknown function; Spider biofilm induced CAALFM_C306970WA Ortholog(s) have role in SRP-dependent cotranslational protein targeting to membrane, translocation and cytosol, nuclear periphery, signal recognition particle, endoplasmic reticulum targeting localization CAALFM_C306980WA Ortholog(s) have UDP-galactose transmembrane transporter activity, role in UDP-galactose transmembrane transport, UDP-glucose transport and endoplasmic reticulum localization CAALFM_C306990WA Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation, vacuole fusion, non-autophagic and Golgi apparatus, endoplasmic reticulum, fungal-type vacuole membrane localization CAALFM_C307000WA Putative histone deacetylase; involved in regulation of white-opaque switch; Spider biofilm repressed CAALFM_C307010WA Protein similar to S. cerevisiae Pos5p, a mitochondrial NADH kinase involved in the oxidative stress response; planktonic growth-induced gene; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C307020WA Functional homolog of S. cerevisiae Cyc8/Ssn6; hyphal growth regulator; repressed during hyphal growth; Ssn6 and Tup1 regulate distinct sets of genes; overexpression or mutation causes avirulence in mouse IV infection; TPR motifs CAALFM_C307030CA Ortholog of C. dubliniensis CD36 : Cd36_86960, C. parapsilosis CDC317 : CPAR2_808800, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113621 and Debaryomyces hansenii CBS767 : DEHA2F02486g CAALFM_C307040CA Predicted Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; role in metabolism of O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; rat catheter biofilm repressed CAALFM_C307050WA Ortholog(s) have enzyme activator activity CAALFM_C307060WA Putative ubiquinone reductase; transcriptionally induced by interaction with macrophage; alkaline downregulated; repressed by nitric oxide; clade-associated gene expression; Hap43p-repressed gene CAALFM_C307070CA Protein of unknown function; Sef1, Sfu1, and Hap43 regulated; rat catheter and Spider biofilm induced CAALFM_C307080WA Putative peptidyl-prolyl cis/trans-isomerase; caspofungin induced CAALFM_C307090WA Putative histone H3; reduced mRNA abundance in fkh2 mutant; farnesol regulated; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C307100CA Ortholog(s) have mRNA binding activity, role in 3'-UTR-mediated mRNA destabilization, mitochondrion organization and cytoplasmic mRNA processing body, cytoplasmic stress granule, cytosol, perinuclear region of cytoplasm localization CAALFM_C307110WA S. cerevisiae ortholog Nud1 is a spindle pole body outer plaque component; it acts through the mitotic exit network to specify asymmetric spindle pole body inheritance; Hap43-induced gene CAALFM_C307120WA Protein with a predicted role in cotranslational protein targeting to membrane; induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_C307130WA Ortholog(s) have receptor activity, role in ER to Golgi vesicle-mediated transport, ascospore formation, axial cellular bud site selection and ER to Golgi transport vesicle, endoplasmic reticulum membrane localization CAALFM_C307140CA Protein of unknown function; flow model biofilm induced CAALFM_C307150CA Acidic ribosomal protein S12; regulated by Gcn4, activated by Tbf1; repressed by amino acid starvation (3-AT); protein abundance is affected by URA3 expression in CAI-4 strain background; sumoylation target; Spider biofilm repressed CAALFM_C307160WA Putative GPI-anchored adhesin-like protein; induced in high iron; Spider biofilm induced CAALFM_C307170CA Putative geranylgeranyltransferase regulatory component CAALFM_C307180CA Beta-mannosyltransferase, required for addition of the 1st beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan; 9-gene family member; mutants induce higher levels of inflammatory cytokines in mouse dendritic cells CAALFM_C307200CA Zn(II)2Cys6 transcription factor; regulator of yeast form adherence; mutants display increased colonization of mouse kidneys; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C307210WA Putative bifunctional dehydrogenase and ferrochelatase with a predicted role in siroheme biosynthesis; regulated by Gcn2p and Gcn4p CAALFM_C307220CA Putative gamma-glutamyl phosphate reductase with a predicted role in proline biosynthesis; regulated by Gcn2p and Gcn4p CAALFM_C307230WA Aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; flow model biofilm repressed CAALFM_C307240WA Ortholog of Candida albicans WO-1 : CAWG_03032 CAALFM_C307250WA Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C307260CA Putative scaffold protein; assists in association of the proteasome core particle with the regulatory particle; ortholog of S. cerevisiae Ecm29; transposon mutation affects filamentous growth; flow model biofilm repressed CAALFM_C307270CA Ubiquitin precursor (polyubiquitin) contains 3 tandem repeats of the ubiquitin peptide that are processed to individual units; transcript induced by stress; mRNA in yeast and mycelia at similar abundance; Spider biofilm induced CAALFM_C307280CA protein with ENTH Epsin domain, N-terminal; Spider biofilm repressed CAALFM_C307290WA Ortholog(s) have cytoplasm localization CAALFM_C307300WA Ortholog of S. cerevisiae Nop13; a nucleolar protein found in preribosomal complexes; Hap43-induced gene; rat catheter biofilm induced CAALFM_C307310CA Alkaline-induced protein of plasma membrane; affects cell aggregation, cell wall; similar to S. cerevisiae Slk19p (a kinetochore protein with roles in mitosis, meiosis); required for wild-type virulence in mouse; macrophage-downregulated CAALFM_C307320WA TOR signaling pathway component; required for growth and hyphal formation at alkaline pH, for full virulence in a mouse model of systemic infection and for SD and Spider medium biofilm formation; role in chlamydospore formation CAALFM_C307330WA Predcted glucose 1-dehydrogenase (NADP+); rat catheter biofilm repressed CAALFM_C307340WA Aldo/keto reductase; mutation confers hypersensitivity to toxic ergosterol analog; farnesol-repressed; stationary phase enriched protein; flow model biofilm induced; Spider biofilm repressed CAALFM_C307350WA Ortholog(s) have Rab GTPase binding activity and Golgi apparatus, endoplasmic reticulum localization CAALFM_C307360WA Ortholog(s) have D-lactate dehydrogenase (cytochrome) activity, role in aerobic respiration, cellular carbohydrate metabolic process and mitochondrial inner membrane localization CAALFM_C307370WA Protein of unknown function; Spider biofilm induced CAALFM_C307380WA Protein with a predicted RING-type zinc finger; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C307390CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C307400WA Ortholog(s) have tRNA methyltransferase activity, role in cytoplasmic translation, tRNA methylation and cytosol, nucleus localization CAALFM_C307410CA Putative tRNA-Lys synthetase; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed CAALFM_C307420WA Ortholog(s) have cytosol, eukaryotic 43S preinitiation complex, eukaryotic translation initiation factor 3 complex, nucleus localization CAALFM_C307430WA Ortholog(s) have acid phosphatase activity, role in dephosphorylation, intracellular sterol transport and cytoplasm, nucleus localization CAALFM_C307440WA Triose-phosphate isomerase; antigenic in mouse/human; mutation affects filamentation; macrophage-repressed; protein in exponential and stationary growth phase yeast; possibly essential; flow model biofilm induced; Spider biofilm repressed CAALFM_C307450CA Ortholog(s) have cytosol, nucleus localization CAALFM_C307460WA Ortholog(s) have CTD phosphatase activity, role in dephosphorylation of RNA polymerase II C-terminal domain, negative regulation of G0 to G1 transition and DNA-directed RNA polymerase II, holoenzyme, cytosol localization CAALFM_C307470WA Putative plasma membrane protein; predicted role in cell wall integrity; regulated by Nrg1, Tup1; induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_C307480WA Ortholog(s) have ubiquitin-protein transferase activity and role in generation of catalytic spliceosome for first transesterification step CAALFM_C307490WA Ortholog(s) have phosphopentomutase activity, role in guanosine catabolic process, inosine catabolic process, purine ribonucleoside salvage and cytosol, nucleus localization CAALFM_C307500WA Member of Mnn9 family of mannosyltransferases; ortholog of S. cerevisiae Van1p; fungal-specific (no human or murine homolog) CAALFM_C307540CA Protein of unknown function; mutants are viable; induced in a cyr1, ras1, or efg1 homozygous null CAALFM_C307550CA Protein required for mitochondrial ribosome small subunit biogenesis; role in maturation of SSU-rRNA; Spider biofilm induced CAALFM_C307560WA Putative transcription factor/corepressor; regulation of filamentation and virulence; interacts with Tup1; regulates hypha-specific gene expression; contains 4 tetratricopeptide repeat (TPR) motifs; flucytosine repressed; Tbp1-induced CAALFM_C307570CA Ortholog(s) have role in cellular response to cold and cytosol, nucleus localization CAALFM_C307580WA Ortholog of C. dubliniensis CD36 : Cd36_87460, C. parapsilosis CDC317 : CPAR2_808260, Debaryomyces hansenii CBS767 : DEHA2F07084g and Pichia stipitis Pignal : psti_CGOB_00185 CAALFM_C307590WA Protein of unknown function; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C307600WA Ortholog(s) have nucleolus localization CAALFM_C307610WA Protein similar to human CAND1 (Cullin-Associated Nedd8-Dissociated) protein involved in regulation of SCF complexes; binds unnedddylated cullin Cdc53; mutants are viable CAALFM_C307620CA Putative initiator tRNA methionine ribosyltransferase; fungal-specific (no human or murine homolog) CAALFM_C307630CA Ortholog(s) have DNA secondary structure binding activity CAALFM_C307640CA Putative fumarate hydratase; enzyme of citric acid cycle; fluconazole, Efg1 repressed; induced in high iron; protein present in exponential and stationary growth phase CAALFM_C307650CA Protein of unknown function; Spider biofilm induced CAALFM_C307660WA Protein similar to S. cerevisiae Rad4p; down-regulation associated with azole resistance CAALFM_C307670WA P-Loop domain-containing protein of unknown function; transposon mutation affects filamentous growth; Spider biofilm induced CAALFM_C307680WA Putative nucleosome assembly protein; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media CAALFM_C307690CA Has domain(s) with predicted sequence-specific DNA binding activity CAALFM_C307700WA Putative serine hydrolase; Spider biofilm repressed CAALFM_C307710WA SAM-dependent RNA methyltransferase; methylates mRNA 5' cap; binds phosphorylated RNA Pol II C-term domain peptide; does not bind mRNA TPase and mRNA GTase (Cet1,Cgt1); functional homolog of S. cerevisiae Abd1; rat catheter biofilm induced CAALFM_C307730WA Predicted C2H2 zinc finger protein, involved in transcriptional regulation of white-opaque phenotypic switching; activator of the opaque cell type CAALFM_C307740WA Ortholog(s) have COPI-coated vesicle, Golgi apparatus localization CAALFM_C307750WA Small-subunit processome protein; Ssr1-induced; repressed by prostaglandins; physically interacts with TAP-tagged Nop1 CAALFM_C307760CA Predicted alpha/beta hydrolase; Spider biofilm induced CAALFM_C307770CA Ortholog(s) have microtubule binding, protein homodimerization activity CAALFM_C307780CA FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; rat catheter biofilm repressed CAALFM_C307790WA Putative transcription factor; involved in control of glucose-regulated gene expression; repressed by Rgt1; Spider biofilm induced CAALFM_C307800CA Putative 35S rRNA processing protein; Hap43-induced; repressed by prostaglandins; Spider biofilm induced CAALFM_C307810CA ER protein-translocation complex subunit; essential; 10 predicted transmembrane regions; chimeric mutant partially functionally complements S. cerevisiae sec61 defects; Spider biofilm repressed CAALFM_C307820WA Protein of unknown function; Spider biofilm repressed CAALFM_C307830WA Fructose-1,6-bisphosphatase; key gluconeogenesis enzyme; regulated by Efg1, Ssn6; induced by phagocytosis; effects switch from glycolysis to gluconeogenesis in macrophage; rat flow model biofilm induced; overlaps orf19.6179 CAALFM_C307840CA Ortholog of Candida albicans WO-1 : CAWG_03090 CAALFM_C307850WA Protein similar to Pichia anomala YDL054c and S. cerevisiae Ydl054cp; transmembrane regions predicted; Hap43p-repressed gene CAALFM_C307860CA Zn(II)2Cys6 transcription factor involved in regulation of multidrug resistance via control of CDR1 expression; mutants display decreased colonization of mouse kidneys; required for yeast cell adherence to silicone substrate CAALFM_C307880CA Protein of unknown function; Spider biofilm repressed CAALFM_C307890WA Predicted mitochondrial intermembrane space protein with role in protein import into mitochondrial inner membrane and cytosol CAALFM_C307900CA Predicted protein of unknown function; overlaps orf19.6185 CAALFM_C307920WA possible pseudouridine monophosphate glycosidase; overlaps orf19.6185 and orf19.618; has intron; Spider biofilm repressed CAALFM_C307910WA Putative pseudouridine-5'-phosphate glycosidase; overlaps orf19.6186 and orf19.6187; Spider biofilm repressed CAALFM_C307930CA Putative adhesin-like protein CAALFM_C307940WA Chalcone related protein family; flow model biofilm induced CAALFM_C307950CA Essential GDP-mannose pyrophosphorylase; makes GDP-mannose for protein glycosylation; functional in S. cerevisiae psa1; on yeast-form, not hyphal cell surface; alkaline induced; induced on adherence to polystyrene; Spider biofilm repressed CAALFM_C307970CA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo CAALFM_C400010WA Member of a family of telomere-proximal genes of unknown function; Hap43p-repressed gene CAALFM_C400020WA Putative vacuolar H+-ATPase subunit; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed CAALFM_C400030CA Ortholog(s) have double-stranded DNA binding activity, role in DNA damage checkpoint, double-strand break repair, reciprocal meiotic recombination and checkpoint clamp complex localization CAALFM_C400040WA Na+/H+ antiporter; required for wild-type growth, cell morphology, and virulence in a mouse model of systemic infection; not transcriptionally regulated by NaCl; fungal-specific (no human or murine homolog) CAALFM_C400050WA Ortholog of C. dubliniensis CD36 : Cd36_40110, C. parapsilosis CDC317 : CPAR2_402300, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94507 and Debaryomyces hansenii CBS767 : DEHA2F05588g CAALFM_C400060WA Putative protein of unknown function; Hap43p-repressed gene CAALFM_C400070CA Ortholog(s) have role in protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway CAALFM_C400080CA Protein of unknown function; Hap43-repressed; Spider biofilm induced CAALFM_C400090WA Putative beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C400100CA F-box domain-containing protein; flow model biofilm induced CAALFM_C400110CA Ferric reductase; alkaline-induced by Rim101; iron-chelation-induced by CCAAT-binding factor; fluconazole-repressed; ciclopirox-, hypoxia-, Hap43-induced; colony morphology-related regulation by Ssn6; Spider and flow model biofilm induced CAALFM_C400120WA GPI-linked hyphal surface antigen; induced by ciclopirox olamine, ketoconazole, Rim101 at pH 8; Hap43, fluconazole; flow model biofilm induced; Spider biofilm induced; required for RPMI biofilm; Bcr1-induced in a/a biofilm CAALFM_C400130WA GPI-linked cell wall protein; hemoglobin utilization; Rfg1, Rim101, Tbf1, Fe regulated; Sfu1, Hog1, Tup1, serum, alkaline pH, antifungal drugs, geldamycin repressed; Hap43 induced; required for RPMI biofilms; Spider biofilm induced CAALFM_C400140CA Multifunctional enzyme that catalyzes three steps of histidine biosynthesis, with phosphoribosyl-AMP cyclohydrolase, phosphoribosyl-ATP diphosphatase, and histidinol dehydrogenase activities; required for wild-type adhesion to human calls CAALFM_C400150CA Pex5p family protein; required for PTS1-mediated peroxisomal protein import, fatty acid beta-oxidation; similar to S. cerevisiae Pas10p peroxisomal targeting receptor; macrophage/pseudohyphal-repressed; Hap43p-repressed CAALFM_C400160CA Ornithine aminotransferase; arginine metabolism; alkaline induced; mutant sensitivite to toxic ergosterol analog, to amphotericin B; exponential and stationary phase yeast; flow model biofilm induced; rat catheter, Spider biofilm repressed CAALFM_C400170WA Ortholog of S. cerevisiae Dif1; which regulates nuclear localization of Rnr2 and Rnr4; colony morphology-related gene regulation by Ssn6; induced in cyr1 mutant; Spider biofilm induced CAALFM_C400180WA Protein involved in control of calcium homeostasis and oxidative stress response; mutants show defects in hyphal growth CAALFM_C400190WA Ortholog(s) have role in ascospore wall assembly, spore membrane bending pathway and cytoplasm, prospore membrane localization CAALFM_C400200CA O-acetylhomoserine O-acetylserine sulfhydrylase; sulfur amino acid synthesis; immunogenic; Hog1, adherence-induced; brown color of mutant in Pb(2+) medium a visual selection; chlamydospore formation induced, F-12/CO2 biofilm induced CAALFM_C400210WA Ortholog of S. cerevisiae : YPL034W, C. glabrata CBS138 : CAGL0L06996g, C. dubliniensis CD36 : Cd36_40280, C. parapsilosis CDC317 : CPAR2_402170 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_137348 CAALFM_C400220CA Putative TREX complex component with a predicted role in nuclear mRNA export; transcription is regulated by Mig1; Hap43-induced gene; Spider biofilm repressed CAALFM_C400230WA Ortholog of C. dubliniensis CD36 : Cd36_40300, C. parapsilosis CDC317 : CPAR2_402190, Candida tenuis NRRL Y-1498 : cten_CGOB_00197 and Debaryomyces hansenii CBS767 : DEHA2F06160g CAALFM_C400240CA Delta 1-pyrroline-5-carboxylate reductase; protein induced during the mating process; alkaline induced; stationary phase enriched protein; Spider biofilm repressed CAALFM_C400250WA Ortholog of Candida lusitaniae ATCC 42720 : CLUG_00275 and Candida albicans WO-1 : CAWG_03759 CAALFM_C400260WA Ortholog(s) have histone demethylase activity (H3-dimethyl-K4 specific), histone demethylase activity (H3-monomethyl-K4 specific), histone demethylase activity (H3-trimethyl-K4 specific) activity CAALFM_C400270WA F1 beta subunit of F1F0 ATPase complex; antigenic in human, mice; induced by ciclopirox olamine; caspofungin repressed; macrophage/pseudohyphal-induced; detected during exponential and stationary growth phases; Spider biofilm repressed CAALFM_C400280WA Prenyl-dependent protease CAALFM_C400290CA Has domain(s) with predicted 2 iron, 2 sulfur cluster binding, iron ion binding, oxidoreductase activity, oxidoreductase activity and acting on paired donors, more CAALFM_C400300CA Protein involved in transcription regulation; ortholog of S. cerevisiae Swi1p, which is a subunit of the SWI/SNF chromatin remodeling complex; interacts with Snf2p; SWI/SNF complex is essential for hyphal growth and virulence CAALFM_C400310CA Alpha-1,6-mannosyltransferase involved in biosynthesis and organization of cell wall polysaccharides CAALFM_C400320CA Ortholog(s) have ubiquitin-protein transferase activity, role in protein import into peroxisome matrix, protein polyubiquitination and endoplasmic reticulum, peroxisomal importomer complex, peroxisomal membrane localization CAALFM_C400330CA Ortholog(s) have proton-transporting ATP synthase activity, rotational mechanism, structural molecule activity and role in ATP synthesis coupled proton transport, cristae formation, protein complex oligomerization CAALFM_C400340WA Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal CAALFM_C400350WA Vesicle transport protein; acts in endosomal transport; roles in metal ion resistance, virulence, adhesion, hyphal growth, chlamydospore formation; similar to S. cerevisiae Pep7p CAALFM_C400360CA Plasma membrane protein; involved in regulation of cytosolic calcium homeostasis; null mutation confers sensitivity to calcium and resistance to azoles and terbinafine; rat catheter biofilm induced CAALFM_C400370WA Ortholog of S. cerevisiae Hof1; a protein localized to the bud neck and required for cytokinesis in S. cerevisiae; periodic mRNA expression, peak at cell-cycle G2/M phase; mutant is viable CAALFM_C400380WA Ortholog(s) have D-arabinose 1-dehydrogenase [NAD(P)+] activity and role in dehydro-D-arabinono-1,4-lactone biosynthetic process CAALFM_C400390WA Ortholog(s) have chromatin binding, transcription coactivator activity CAALFM_C400400WA Putative ion transporter; fungal-specific (no human or murine homolog) CAALFM_C400410WA Protein with B-cell receptor-associated protein 31-like domain; membrane-localized protein CAALFM_C400420CA Ortholog(s) have enzyme inhibitor activity and role in actin cortical patch assembly, negative regulation of catalytic activity, septin cytoskeleton organization CAALFM_C400430WA Ammonium permease and regulator of nitrogen starvation-induced filamentation; 11 predicted transmembrane regions; in low nitrogen cytoplasmic C-terminus activates Ras/cAMP and MAPK signal transduction pathways to induce filamentation CAALFM_C400440CA Putative oligopeptide transporter; possibly transports GSH or related compounds; Hog1-induced; expression of OPT6, -7, or -8 does not suppress defect of mutant lacking OPT1-3; Hap43-repressed; F-12/CO2 early biofilm induced CAALFM_C400450CA GPI anchored membrane protein; utilization of hemin and hemoglobin for Fe in host; Rim101 at ph8/hypoxia/ketoconazole/ciclopirox/hypha-induced; required for RPMI biofilm formation, Bcr1-induced in a/a biofilm; rat catheter biofilm repressed CAALFM_C400460CA Protein involved in proteolytic control of sumoylated substrates; interacts with SUMO; member of the SWI/SNF family of DNA-dependent ATPases; Spider biofilm induced CAALFM_C400470CA Ortholog(s) have cytosol, nucleus localization CAALFM_C400480WA Putative urea permease; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C400490WA Has domain(s) with predicted role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytoplasm localization CAALFM_C400500WA Ortholog(s) have ubiquitin-ubiquitin ligase activity CAALFM_C400510CA Putative ribosomal protein; Hap43-induced; essential gene; heterozygous mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Spider biofilm induced CAALFM_C400520WA Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix; rat catheter biofilm induced CAALFM_C400530CA Has domain(s) with predicted hydrolase activity CAALFM_C400540CA Karyopherin; carrier protein involved in nuclear import of proteins; repressed in core stress response; Hap43-induced; Spider biofilm induced CAALFM_C400560CA Ortholog(s) have role in hyphal growth, mitochondrial genome maintenance, mitochondrial outer membrane translocase complex assembly, mitochondrion-ER tethering and phospholipid transport, more CAALFM_C400570CA Putative choline-phosphate cytidylyl transferase, antigenic during human oral infection CAALFM_C400580WA Ortholog(s) have phosphoprotein phosphatase activity, thiosulfate sulfurtransferase activity, role in protein dephosphorylation and cytosol, nucleus localization CAALFM_C400590CA Protein with a predicted role in clathrin cage assembly; Hap43-repressed; Spider biofilm repressed CAALFM_C400600CA Protein similar to S. cerevisiae Muc1; a cell surface glycoprotein involved in filamentous growth; repressed by benomyl treatment; mutant is viable CAALFM_C400610WA Ortholog(s) have role in response to drug and mitochondrion localization CAALFM_C400620CA Signal peptidase complex component; role in ER protein translocation; transcript is induced upon filamentous growth CAALFM_C400630CA ER protein-translocation complex component; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); sumoylation target CAALFM_C400640WA Putative adhesin-like protein CAALFM_C400650WA Putative histidinol-phosphate aminotransferase; Gcn4p-regulated; protein present in exponential and stationary growth phase yeast cultures CAALFM_C400660WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C400670WA Outwardly rectifying, noisily gated potassium channel; modulates sensitivity to human salivary histatin (Hst5); very similar to S. cerevisiae Tok1p; Bcr1-repressed in RPMI a/a biofilms CAALFM_C400680WA Ortholog(s) have nicotinamide riboside transmembrane transporter activity, nucleobase transmembrane transporter activity and role in nicotinamide riboside transport, nucleobase transport, transmembrane transport CAALFM_C400690CA Ortholog(s) have role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytoplasm localization CAALFM_C400700CA Has domain(s) with predicted hydrolase activity and role in metabolic process CAALFM_C400710WA Has domain(s) with predicted ATP binding activity CAALFM_C400720WA Putative cell wall associated protein; C. albicans and C. dubliniensis specific gene highly induced during chlamydospore development in both species; localized to chlamydospore cell wall; Hap43-repressed; Spider biofilm induced CAALFM_C400730CA Ortholog of C. dubliniensis CD36 : Cd36_40780, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116553, Lodderomyces elongisporus NRLL YB-4239 : LELG_04263 and Debaryomyces hansenii CBS767 : DEHA2G21736g CAALFM_C400740WA Ortholog(s) have RNA binding, ribonuclease MRP activity, ribonuclease P activity CAALFM_C400750CA Protein of unknown function; Spider biofilm induced CAALFM_C400760WA Predicted Zn(II)2Cys6 transcription factor; mutants display increased colonization of mouse kidneys; Spider biofilm induced CAALFM_C400770CA Ortholog(s) have mitochondrion, ribosome localization CAALFM_C400780CA Ortholog(s) have role in establishment of protein localization to plasma membrane, protein targeting to vacuole, receptor-mediated endocytosis, response to pheromone CAALFM_C400790CA Putative mismatch repair protein; cell-cycle regulated periodic mRNA expression CAALFM_C400800WA Ortholog(s) have SUMO transferase activity, role in DNA repair and Smc5-Smc6 complex, nucleus localization CAALFM_C400810CA Ortholog(s) have role in mitochondrial tRNA threonylcarbamoyladenosine modification, tRNA threonylcarbamoyladenosine modification and mitochondrion localization CAALFM_C400820WA Ortholog(s) have magnesium ion transmembrane transporter activity, role in magnesium ion export from mitochondrion, magnesium ion transport and mitochondrial inner membrane localization CAALFM_C400830WA Peroxisomal 2,4-dienoyl-CoA reductase; stationary phase enriched protein; Spider biofilm induced CAALFM_C400840WA Ortholog of C. dubliniensis CD36 : Cd36_40890, C. parapsilosis CDC317 : CPAR2_401100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119698 and Debaryomyces hansenii CBS767 : DEHA2G22154g CAALFM_C400850CA Putative secreted acid sphingomyelin phosphodiesterase; possible Kex2p substrate CAALFM_C400860CA Protein of unknown function; induced in cyr1 or ras1 mutant; induced by fluconazole, by alpha pheromone in SpiderM medium and during oralpharyngeal candidasis; Spider biofilm induced CAALFM_C400880WA Ortholog(s) have tRNA adenylyltransferase activity, role in tRNA 3'-terminal CCA addition and mitochondrial matrix localization CAALFM_C400890WA Putative pentafunctional arom enzyme; fungal-specific (no human or murine homolog); Gcn2p-, Gcn4p-regulated CAALFM_C400910CA Protein with similarity to mutator-like element (MULE) transposase CAALFM_C400920CA Possible similarity to mutator-like element (MULE) transposase; flow model biofilm induced; expression regulated during planktonic growth CAALFM_C400940WA Ortholog(s) have ATPase activity, tRNA binding activity, role in protein urmylation, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex localization CAALFM_C400950CA Putative phospholipase of patatin family; similar to S. cerevisiae Tgl3p; predicted Kex2p substrate CAALFM_C400960WA Predicted type 2C protein phosphatase, ser/thr-specific; required for hyphal growth; transcript induced by stress; flow model biofilm induced; Spider biofilm induced CAALFM_C400970CA Putative midasin, a very large dynein-related AAA-type ATPase; induced during the mating process CAALFM_C400980CA Ortholog of Candida albicans WO-1 : CAWG_03682 CAALFM_C400990WA NRAMP metal ion transporter domain-containing protein; induced by nitric oxide independent of Yhb1; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C401000CA Putative GPI-anchored protein; Hap43p-induced gene CAALFM_C401010CA Secretory protein; a-specific, alpha-factor induced; mutation confers hypersensitivity to toxic ergosterol analog; fluconazole-induced; induced during chlamydospore formation in C. albicans and C. dubliniensis CAALFM_C401020CA Ortholog of S. cerevisiae : ESL1, C. dubliniensis CD36 : Cd36_41030, C. parapsilosis CDC317 : CPAR2_401340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104645 and Debaryomyces hansenii CBS767 : DEHA2E18766g CAALFM_C401050CA Protein with similarity to the ribosomal protein portion of S. cerevisiae Rpl40Bp; colony morphology-related gene regulation by Ssn6; positively regulated by Tbf1; Spider biofilm repressed CAALFM_C401060WA Ortholog(s) have mRNA binding, ribonucleoprotein complex binding activity CAALFM_C401070WA Putative MFS family glucose transporter; 20 members in C. albicans; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media; Spider biofilm induced CAALFM_C401080WA 5'-->3' exoribonuclease; similar to S. cerevisiae nuclear exoribonuclease Rat1p; suppresses S. cerevisiae kem1 mutant slow growth, mating defect, and haploid invasive growth defect CAALFM_C401090CA Possile protease; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_C401100CA Amino acid permease; hyphal repressed; white-opaque switch regulated; induced in core caspofungin response, during cell wall regeneration, by flucytosine; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced CAALFM_C401120CA Predicted triglyceride lipase; Spider biofilm induced CAALFM_C401130CA Putative protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced CAALFM_C401140CA Protein with homology to mitochondrial intermembrane space proteins; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C401150WA Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C401160WA Metallothionein; for adaptation to growth in high copper; basal transcription is cadmium-repressed; Ssn6 regulated; complements copper sensitivity of an S. cerevisiae cup1 mutant; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced CAALFM_C401170CA Beta-mannosyltransferase, 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; regulated by Sef1, Sfu1, Hap43; rat catheter biofilm repressed CAALFM_C401190WA Transcription factor; cell wall damage response; required for adherence, response/resistance to caspofungin; repressed in core stress response; mutants have reduced CFU in mice, hyphal defect in C. elegans infection; Spider biofilm induced CAALFM_C401200CA Aspartate aminotransferase; nitrogen metabolism; similar but not orthologous to S. cerevisiae Aat2; clade-associated gene expression; protein levels decrease in stationary phase yeast; mutant is viable; flow model biofilm repressed CAALFM_C401220CA Protein with a glycoside hydrolase domain; mutants are viable CAALFM_C401230CA Protein of unknown function; hyphal-induced expression, regulated by Cyr1, Ras1, Efg1; Spider biofilm induced CAALFM_C401240CA Protein of unknown function; Spider biofilm induced CAALFM_C401250WA Putative histone acetyltransferase; involved in regulation of white-opaque switch; early-stage flow model biofilm induced; Spider biofilm induced CAALFM_C401260WA Putative transcription factor; required for wild-type resistance to cell wall perturbation, caspofungin treatment; regulates caspofungin induction of PGA13 CAALFM_C401270WA Ribosomal protein 6A; localizes to cell surface of yeast cells but not hyphae; repressed upon phagocytosis by murine macrophage; possibly essential; Hap43-induced; Spider biofilm repressed CAALFM_C401280CA Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U2 snRNP, U2-type prespliceosome localization CAALFM_C401290WA RING finger and CHY zinc finger domain-containing protein; mutant are viable CAALFM_C401300WA Ortholog(s) have phosphoprotein phosphatase activity and role in negative regulation of phospholipid biosynthetic process, nuclear envelope organization, positive regulation of phosphatidate phosphatase activity, protein dephosphorylation CAALFM_C401310WA Ortholog of C. dubliniensis CD36 : Cd36_41300, C. parapsilosis CDC317 : CPAR2_400390, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94704 and Debaryomyces hansenii CBS767 : DEHA2B02992g CAALFM_C401320CA Putative oligopeptide transporter; fungal-specific (no human or murine homolog); expression of OPT6, OPT7, or OPT8 does not suppress defect of mutant lacking Opt1p, Opt2p, and Opt3p; alleles are nonidentical CAALFM_C401340WA Protein similar to GPI-linked cell-wall proteins; induced in low iron; Spider biofilm induced; regulated in Spider biofilms by Bcr1, Tec1, Ndt80, Brg1 CAALFM_C401360WA GPI-anchored cell surface protein of unknown function; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type CAALFM_C401370WA Putative regulatory subunit of acetolacetate synthase; alkaline induced; regulated by Gcn2 and Gcn4; protein present in exponential and stationary growth phase yeast; Spider biofilm repressed CAALFM_C401380WA Putative Zn(II)2Cys6 transcription factor CAALFM_C401390WA Predicted CCAAT-binding transcription factor that regulates respiration; Cap2-dependent induction in low iron; opaque specific, alkaline, ciclopirox olamine induced; regulated by Sef1, Sfu1, Hap43; Bcr1-regulated in RPMI a/a biofilms CAALFM_C401400WA Protein required for damage to oral epithelial cells and for normal hyphal growth and stress resistance; transcription induced on contact with vascular endothelial cells; not highly conserved CAALFM_C401410WA Protein required for wild-type budding, hyphal growth, and virulence in a mouse systemic infection; suppresses pseudohyphal and filamentous growth defects of various S. cerevisiae mutants and heat sensitivity of S. cerevisiae cdc24-4 mutant CAALFM_C401420WA Ortholog of C. dubliniensis CD36 : Cd36_41430, Candida tropicalis MYA-3404 : CTRG_00187 and Candida albicans WO-1 : CAWG_03642 CAALFM_C401430CA Protein of unknown function; Hap43-induced gene CAALFM_C401440WA Myristoyl-CoA:protein N-myristoyltransferase; attaches the fatty acid myristate to a small number of proteins at an N-terminal Gly; essential; antifungal drug target; functional homolog of S. cerevisiae Nmt1p CAALFM_C401450WA Putative rRNA processing protein; Hap43-induced; repressed in core stress response CAALFM_C401460CA Protein present in exponential and stationary growth phase yeast cultures CAALFM_C401470WA Ortholog(s) have role in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cellular response to methylmercury and SCF ubiquitin ligase complex localization CAALFM_C401490WA Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C401500WA Protein required for thiolation of uridine at wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation; S. cerevisiae ortholog has a role in invasive and pseudohyphal growth CAALFM_C401510WA Ortholog(s) have carbonyl reductase (NADPH) activity, serine 3-dehydrogenase activity and cytosol, nucleus, ribosome localization CAALFM_C401520CA Ribosomal protein L20; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5' UTR; Hap43-induced; Spider biofilm repressed CAALFM_C401530CA C-4 sterol methyl oxidase; role in ergosterol biosynthesis; Hap43-induced; ketoconazole-induced; amphotericin B, caspofungin repressed; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed CAALFM_C401550CA Putative carbamoyl-phosphate synthase subunit; alkaline repressed; rat catheter, Spider and flow model biofilm induced CAALFM_C401560CA Ortholog(s) have ubiquitin-ubiquitin ligase activity, role in mitochondrion inheritance, protein monoubiquitination, protein polyubiquitination and plasma membrane, ubiquitin ligase complex localization CAALFM_C401650CA Putative cleavage and polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C401660WA Ortholog(s) have structural constituent of nuclear pore activity CAALFM_C401670CA Ortholog(s) have role in TOR signaling, positive regulation of transcription from RNA polymerase I promoter and cytosol, extrinsic component of membrane, nucleus localization CAALFM_C401680WA Putative TFIIA small subunit; protein abundance decreased in CAI4 strain compared to the SC5314 strain, abundance not affected by reintegration of URA3 in CAI4; flucytosine induced; possibly an essential gene (UAU1 method) CAALFM_C401690CA Protein described as having a role in Ty3 transposition; repressed in hyphae; stationary phase enriched protein; rat catheter and Spider biofilm repressed CAALFM_C401700CA Putative non-histone chromatin component; RNA abundance regulated by tyrosol,cell density; Hap43-induced; amphotericin B, caspofungin repressed; 5'-UTR intron; rat catheter and Spider biofilm repressed CAALFM_C401710CA Protein of unknown function; Spider biofilm repressed CAALFM_C401720CA Ortholog(s) have role in protein ubiquitination, telomere maintenance, transcription-coupled nucleotide-excision repair, ubiquitin-dependent protein catabolic process and nucleus localization CAALFM_C401730CA Ortholog(s) have cytoplasmic mRNA processing body, cytosol, nucleus localization CAALFM_C401740WA Predicted component of the TIM22 complex, involved in protein import into mitochondrial inner membrane; flow model biofilm induced CAALFM_C401750CA Fructose-bisphosphate aldolase; glycolytic enzyme; antigenic in murine/human infection; regulated by yeast-hypha switch; induced by Efg1, Gcn4, Hog1, fluconazole; phagocytosis-repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C401760WA Predicted peptide alpha-N-acetyltransferase; flow model biofilm induced CAALFM_C401770WA Proliferating cell nuclear antigen (PCNA), forms homotrimeric sliding clamp for DNA polymerases; RNA abundance regulated by tyrosol, cell density; induced by flucytosine, interaction with macrophages; stationary phase enriched protein CAALFM_C401780CA Ortholog(s) have histone deacetylase activity CAALFM_C401790WA Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; Spider biofilm induced CAALFM_C401800WA Protein with a dienelactone hydrolase domain; Hap43-repressed gene CAALFM_C401820CA Ortholog(s) have ribose phosphate diphosphokinase activity, role in 5-phosphoribose 1-diphosphate biosynthetic process, cytokinesis, fungal-type cell wall organization and cytosol, ribose phosphate diphosphokinase complex localization CAALFM_C401830CA Predicted metallocarboxypeptidase; role in proteolysis; rat catheter biofilm repressed CAALFM_C401840CA Putative dienelactone hydrolase; protein abundance is affected by URA3 expression in the CAI-4 strain background; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressed CAALFM_C401850CA Putative pyruvate decarboxylase; fungal-specific (no human or murine homolog) CAALFM_C401860CA Possible Golgi membrane protein; Hap43-repressed; hypha induced; flow model biofilm induced; Spider biofilm induced CAALFM_C401870CA Putative phosphomevalonate kinase; enzyme of the mevalonate pathway of isoprenoid biosynthesis; transcript regulated by Nrg1; possible drug target; not conserved in H. sapiens CAALFM_C401880WA Putative prepephenate dehydrogenase; enzyme of tyrosine biosynthesis; fungal-specific (no human or murine homolog) CAALFM_C401890CA Putative GTPase; mutation confers dose-dependent sensitivity to Brefeldin A CAALFM_C401900CA Predicted malate dehydrogenase precursor; macrophage-induced transcript; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_C401910WA Putative RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C401920WA Dolichol-phosphate mannose synthase subunit, essential for enzyme activity; flow model biofilm repressed CAALFM_C401930CA Protein of unknown function; possible mitochondrial protein; Spider biofilm induced CAALFM_C401940WA Putative phosphate permease; transcript regulated upon white-opaque switch; alkaline induced by Rim101; possibly adherence-induced; F-12/CO2 model, rat catheter and Spider biofilm induced CAALFM_C401950WA Putative F-actin-capping protein subunit beta; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C401960CA Protein of unknown function; Spider biofilm induced CAALFM_C401970WA Ortholog of C. dubliniensis CD36 : Cd36_41860, C. parapsilosis CDC317 : CPAR2_400440, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103033 and Debaryomyces hansenii CBS767 : DEHA2B03234g CAALFM_C401980CA Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; rat cathetr and Spider biofilm repressed CAALFM_C401990WA Protein with a predicted role in mitochondrial respiratory chain complex II assembly; rat catheter biofilm induced CAALFM_C402000CA Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42; involved in cell signaling pathways controlling cell polarity; induced by low-level peroxide stress; flow model biofilm induced CAALFM_C402010CA UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthase [GCS]); involved in glucosylceramide biosynthesis, which is important for virulence CAALFM_C402020WA Major carnitine acetyl transferase; intracellular acetyl-CoA transport; localized in peroxisomes and mitochondria; induced in macrophages; Hog1-repressed; stationary phase enriched; farnesol-upregulated in biofilm; Spider biofilm induced CAALFM_C402030WA Transcriptional repressor; regulator of filamentation, response to DNA damage, adhesion, virulence in murine mucosal, systemic infections; RFX domain; regulated by Nrg1, UV-induced; partially complements S. cerevisiae rfx1 mutant defects CAALFM_C402040WA Ortholog(s) have polyamine oxidase activity, role in pantothenate biosynthetic process, spermine catabolic process and cytoplasm localization CAALFM_C402050WA Putative HMG1/2-related protein; transcript regulated by Mig1 CAALFM_C402060CA Protein similar to S. cerevisiae Tfg1p, which is part of transcription factor TFIIF; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C402070WA Acid phosphatase; induced by Mnl1 under weak acid stress; Spider biofilm induced CAALFM_C402080WA Protein with a mitochondrial carrier protein domain; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed CAALFM_C402090CA Ortholog(s) have role in U1 snRNA 3'-end processing, U4 snRNA 3'-end processing and U5 snRNA 3'-end processing, more CAALFM_C402100CA Putative glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions CAALFM_C402110WA Protein of unknown function; Hap43-repressed gene CAALFM_C402120WA Putative SURF4 family member; plasma membrane-localized; flow model biofilm repressed CAALFM_C402130WA Cytochrome c1 heme lyase; transcript regulated by Nrg1; induced in high iron CAALFM_C402140CA Predicted protein of the mitochondrial intermembrane space with role in protein import into mitochondrial inner membrane CAALFM_C402150CA Ortholog(s) have GTPase activating protein binding, cAMP-dependent protein kinase inhibitor activity, signal transducer activity CAALFM_C402160CA Ortholog(s) have mitochondrion localization CAALFM_C402170CA Ortholog(s) have lysophospholipase activity, role in lipid homeostasis and lipid particle localization CAALFM_C402180CA Zn2-Cys6 transcription factor of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C402190CA CoA-transferase family protein; rat catheter biofilm repressed CAALFM_C402200CA Ortholog of C. dubliniensis CD36 : Cd36_42090, Debaryomyces hansenii CBS767 : DEHA2C14872g, Pichia stipitis Pignal : PICST_74821 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_58607 CAALFM_C402210WA Ortholog of C. dubliniensis CD36 : Cd36_42100, Debaryomyces hansenii CBS767 : DEHA2C14850g, Pichia stipitis Pignal : PICST_52615 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_58608 CAALFM_C402220CA Putative Zn(II)2Cys6 transcription factor CAALFM_C402230CA Catechol 1,2-dioxygenase (1,2-CTD), involved in degradation of aromatic compounds; Spider biofilm induced CAALFM_C402240CA Protein similar to S. cerevisiae Rot1p, which has roles in cytoskeletal dynamics and cell wall biosynthesis; predicted Kex2p substrate CAALFM_C402250CA Cell wall 1,3-beta-glucosyltransferase; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection; rat catheter biofilm induced CAALFM_C402260CA Protein of unknown function; repressed by prostaglandins; Hap43-induced, Spider biofilm induced CAALFM_C402270CA Protein involved in the maintenance of normal ploidy; S. cerevisiae ortholog cofers Brefeldin A resistance; stationary phase enriched protein; Spider biofilm repressed CAALFM_C402280WA Ortholog(s) have isopentenyl-diphosphate delta-isomerase activity, role in farnesyl diphosphate biosynthetic process and cytosol, nucleus localization CAALFM_C402290WA Ortholog(s) have role in protein lipoylation and mitochondrion localization CAALFM_C402300WA Histone deacetylase; similar to S. cerevisiae Hos3p; greater expression and longer mRNA in white cells, compared to opaque cells; has conserved deacetylation motif CAALFM_C402310WA Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42p; involved in cell signaling pathways that control cell polarity; similar to S. cerevisiae Bem3p CAALFM_C402320CA Cytosolic copper- and zinc-containing superoxide dismutase; role in protection from oxidative stress; required for full virulence; alkaline induced by Rim101; induced by human blood; rat catheter, flow model and Spider biofilm repressed CAALFM_C402330CA Ortholog of C. dubliniensis CD36 : Cd36_42220, C. parapsilosis CDC317 : CPAR2_500340, Debaryomyces hansenii CBS767 : DEHA2G17754g and Pichia stipitis Pignal : PICST_31424 CAALFM_C402340WA Putative protease B inhibitor; hyphal-induced expression; Cyr1p- and Ras1p-repressed CAALFM_C402360WA Putative alpha-mannosidase; transcript regulated by Nrg1; induced during cell wall regeneration; flow model biofilm induced; Spider biofilm induced CAALFM_C402370CA Adhesin-like cell wall protein; putative GPI-anchor; colony morphology-related gene regulation by Ssn6; Hap43-induced; Spider biofilm repressed CAALFM_C402390WA Adhesin-like cell wall protein; putative GPI-anchor; fluconazole-induced; induced in high iron; induced during cell wall regeneration; Cyr1 or Ras1 repressed; Tbf1 induced CAALFM_C402400CA Protein not essential for viability; orf19.10279 possibly transcriptionally regulated upon hyphal formation CAALFM_C402410CA Alkyl hydroperoxide reductase; immunogenic; fluconazole-induced; amphotericin B, caspofungin, alkaline repressed; core stress response induced; Ssk1/Nrg1/Tup1/Ssn6/Hog1 regulated; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C402420CA Putative glycosylphosphatidylinositol (GPI) anchor assembly protein; transposon insertion causes decreased colony wrinkling but does not block true hyphal growth; induced by nitric oxide independent of Yhb1p CAALFM_C402430WA Putative mRNA cleavage and polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C402440CA Putative adhesin-like GPI-anchored protein; repressed during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm repressed CAALFM_C402450WA Has domain(s) with predicted role in cell redox homeostasis CAALFM_C402460WA Ortholog(s) have HDEL sequence binding activity, role in ER to Golgi vesicle-mediated transport, protein retention in ER lumen and Golgi apparatus, integral component of endoplasmic reticulum membrane localization CAALFM_C402470CA Ortholog(s) have role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process and cytosol, nucleus, proteasome core complex, beta-subunit complex localization CAALFM_C402480CA Predicted mitochondrial intermembrane space protein with a role in protein import into mitochondria CAALFM_C402490WA Predicted Zn(II)2Cys6 transcription factor of unknown function; rat catheter biofilm induced CAALFM_C402500CA C2H2 transcription factor; ortholog of S. cerevisiae Adr1 but mutant phenotype suggests a different set of target genes; transposon mutation affects filamentous growth; Spider biofilm induced CAALFM_C402510WA Predicted membrane transporter; member of the monocarboxylate porter (MCP) family, major facilitator superfamily; Hap43-induced gene; alkaline upregulated by Rim101; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C402520CA BTB/POZ domain protein; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced CAALFM_C402530WA GAL4-like Zn(II)2Cys6 transcription factor; clade-associated expression; null shows abnormal regulation of invasive colony growth, is unable to utilize proline as a nitrogen source; flow model biofilm induced CAALFM_C402540WA Zn(II)2Cys6 transcription factor; transcriptional repressor involved in the regulation of glucose transporter genes; ortholog of S. cerevisiae Rgt1; mutants display decreased colonization of mouse kidneys CAALFM_C402550CA Protein with a role in endosome-to-vacuole sorting; rat catheter biofilm repressed CAALFM_C402560CA Putative transcription factor with zinc cluster DNA-binding motif; similar to S. cerevisiae Ume6p, which is a transcription factor involved in the regulation of meiotic genes CAALFM_C402570CA Ortholog(s) have histone demethylase activity (H3-K36 specific), histone demethylase activity (H3-K9 specific), sequence-specific DNA binding and transcriptional repressor activity, more CAALFM_C402580WA Ortholog of C. parapsilosis CDC317 : CPAR2_400095, C. dubliniensis CD36 : Cd36_42560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113280 and Lodderomyces elongisporus NRLL YB-4239 : LELG_04166 CAALFM_C402590CA Ortholog(s) have 5'-flap endonuclease activity CAALFM_C402600CA Ortholog(s) have histone binding activity, role in DNA replication-dependent nucleosome assembly and CAF-1 complex, chromosome, centromeric region, nucleus localization CAALFM_C402610CA Putative sulfate transporter; transcript negatively regulated by Sfu1; amphotericin B induced; F-12/CO2 and Spider biofilm induced CAALFM_C402620CA Carbohydrate kinase domain-containing protein; Spider biofilm induced CAALFM_C402630CA HAP5-like; ortholog of S. cerevisiae Bur6, a heterodimeric NC2 transcription regulator complex subunit; flucytosine induced CAALFM_C402640CA Putative tRNA splicing endonuclease subunit; mutation confers hypersensitivity to toxic ergosterol analog and to amphotericin B; 5'-UTR intron; Hap43-induced; Spider biofilm induced CAALFM_C402660WA Protein with a glucose/ribitol dehydrogenase family domain; mutants are viable CAALFM_C402670WA Putative subunit of phosphatidylinositol 3-kinase complexes I and II; transcription is activated in the presence of elevated CO2 CAALFM_C402680CA Ortholog of Debaryomyces hansenii CBS767 : DEHA2E16016g, Pichia stipitis Pignal : PICST_38487, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_58603 and Candida tropicalis MYA-3404 : CTRG_00248 CAALFM_C402690WA Has domain(s) with predicted zinc ion binding activity CAALFM_C402700WA Ortholog(s) have DNA clamp loader activity, role in DNA damage checkpoint, nucleotide-excision repair, reciprocal meiotic recombination and Rad17 RFC-like complex, nucleus localization CAALFM_C402710CA Putative glutaredoxin; flucytosine induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) CAALFM_C402720CA Putative plasma membrane protein; Plc1-regulated; Spider biofilm induced CAALFM_C402740WA Protein of unknown function; flow model, rat catheter and Spider biofilm induced; Hap43-repressed CAALFM_C402750WA Ortholog of S. cerevisiae Hit1; protein of unknown function required for high temperature growth; flow model biofilm induced; Spider biofilm induced CAALFM_C402760CA Negative regulator of yeast-form growth; HSP70 family member; induced by growth cessation at yeast-hyphal transition or in planktonic growth; physically interacts with Msi3p; similar to rat anti-aging gene, SMP30, stationary phase enriched CAALFM_C402770CA Ortholog(s) have ATP binding, magnesium ion binding activity, role in formation of cytoplasmic translation initiation complex, regulation of mitotic cell cycle, regulation of translation and cytosol, nucleus localization CAALFM_C402780WA Cytosolic chaperonin Cct ring complex subunit; role in the assembly of actin and tubulins; Spider biofilm repressed CAALFM_C402790CA Putative U3-containing small subunit processome complex subunit; Hap43p-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); repressed upon high-level peroxide stress CAALFM_C402800WA Ortholog(s) have RNA polymerase III activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex localization CAALFM_C402820WA Ortholog(s) have role in reciprocal meiotic recombination and nucleus localization CAALFM_C402830CA Putative role in regulation of cell wall biogenesis; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method; flow model and rat catheter biofilm induced CAALFM_C402840CA Subunit of the RNA polymerase II mediator complex; involved in control of filamentous growth and Spider biofilm formation; rat catheter biofilm repressed CAALFM_C402850WA Similar to S. cerevisiae Elp2, an Elongator complex subunit required for modification of wobble nucleosides in tRNA; repressed in core stress response CAALFM_C402860WA Ortholog(s) have enzyme activator activity, role in chromosome segregation and cytoplasm, nucleus localization CAALFM_C402870CA Ortholog of S. cerevisiae Zuo1; a cytosolic ribosome-associated chaperone; likely to be essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed CAALFM_C402880CA Ortholog(s) have guanyl-nucleotide exchange factor activity, role in mature ribosome assembly and cytosol, nucleolus, polysome, preribosome, large subunit precursor localization CAALFM_C402890CA Putative ubiquinol cytochrome c reductase; shows colony morphology-related gene regulation by Ssn6p CAALFM_C402900CA GPI-anchored cell wall transglycosylase, putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p and to antigenic A. fumigatus Aspf9; predicted Kex2p substrate; caspofungin-induced CAALFM_C402920WA Specificity factor required for ubiquitination and sorting of specific cargo proteins at the multivesicular body; ortholog of S. cerevisiae Ear1; transcript regulated by iron; Ssr1-represssed; Spider biofilm induced CAALFM_C402930WA Protein of unknown function; Ras1 and Cyr1 repressed; rat catheter and Spider biofilm induced CAALFM_C402940WA Ortholog of S. cerevisiae Abp1; actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein only detected in stationary phase yeast-form cultures; Spider biofilm repressed CAALFM_C402950CA Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization CAALFM_C402960WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_C402970CA Protein similar to S. cerevisiae Ubr1p ubiquitin-protein ligase; transposon mutation affects filamentous growth; Spider biofilm induced CAALFM_C402980WA Putative tRNA-Tyr synthetase; downregulated upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed CAALFM_C402990CA Glutathione S transferase; induced by benomyl and in populations of cells exposed to fluconazole over multiple generations; regulated by Nrg1, Tup1; induced by nitric oxide; stationary phase enriched; Spider biofilm induced CAALFM_C403000CA Planktonic growth-induced gene CAALFM_C403020WA Putative mitochondrial GTPase; required for mitochondrial morphology and genome maintenance; Spider biofilm induced CAALFM_C403030CA Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p CAALFM_C403040WA Ortholog(s) have RNA polymerase I activity, RNA polymerase II activity, RNA polymerase III activity, RNA-directed RNA polymerase activity, zinc ion binding activity CAALFM_C403050CA Ortholog(s) have carboxypeptidase activity, role in nitrogen compound metabolic process, proteolysis involved in cellular protein catabolic process and fungal-type vacuole lumen localization CAALFM_C403070WA GPI-anchored protein; Hog1-repressed; induced in cyr1 or efg1 mutant or in hyphae; colony morphology-related gene regulation by Ssn6; induced in RHE model; mRNA binds She3; regulated in Spider biofilms by Tec1, Egf1, Ntd80, Rob1, Brg1 CAALFM_C403080WA Protein of unknown function; flow model biofilm repressed CAALFM_C403090WA Ortholog(s) have RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly, TBP-class protein binding activity CAALFM_C403100WA Protein with similarity to RNase T2 enzymes; has putative secretion signal; expression is Tup1-repressed CAALFM_C403110WA Ortholog(s) have phospholipid-translocating ATPase activity and role in intracellular protein transport, phospholipid translocation, response to pheromone involved in conjugation with cellular fusion CAALFM_C403120CA Putative cell cycle checkpoint kinase; mutation confers increased sensitivity to nocodazole CAALFM_C403130WA Putative GPI transamidase component; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C403140CA Predicted hexameric RecA-like ATPase Elp456 Elongator subcomplex subunit; required for modification of wobble nucleosides in tRNA; Spider biofilm induced CAALFM_C403150WA Ortholog(s) have mRNA binding activity, role in spliceosomal complex assembly and U2 snRNP, U2-type prespliceosome localization CAALFM_C403160CA Putative transcription factor with zinc finger DNA-binding motif; Hap43p-repressed gene CAALFM_C403170WA Ortholog(s) have SUMO transferase activity, role in DNA repair and Smc5-Smc6 complex, cytoplasm, nucleus localization CAALFM_C403180WA NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed CAALFM_C403190WA Protein with a predicted FAD-dependent pyridine nucleotide reductase domains; putative oxidoreductase; Plc1-regulated; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C403200CA Ortholog(s) have 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity, role in fatty acid biosynthetic process and mitochondrion localization CAALFM_C403230CA ORF in retrotransposon Tca4; similar to Pol region of retrotransposons encoding reverse transcriptase, protease, integrase; downstream of RHD2, similar to the Gag region encoding nucleocapsid-like protein; rat catheter biofilm induced CAALFM_C403250CA Predicted ORF in retrotransposon Tca4 with similarity to the Gag region encoding nucleocapsid-like protein; overlaps blocked reading frame orf19.2668.1; yeast-enriched transcript; rat catheter biofilm induced CAALFM_C403270WA Putative nucleolar protein with a predicted role in the assembly and export of the large ribosomal subunit; essential for growth; rat catheter and Spider biofilm induced CAALFM_C403280WA Predicted karyopherin involved in nuclear import and export of proteins; flow model biofilm induced; Spider biofilm induced CAALFM_C403290WA Ortholog(s) have role in cellular response to DNA damage stimulus, interspecies interaction between organisms and cytoplasmic mRNA processing body, cytosol, nuclear periphery, polysome localization CAALFM_C403300CA Ortholog of C. dubliniensis CD36 : Cd36_62310 CAALFM_C403310CA Protein of unknown function CAALFM_C403320WA Ortholog of C. dubliniensis CD36 : Cd36_43090, C. parapsilosis CDC317 : CPAR2_403340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94387 and Debaryomyces hansenii CBS767 : DEHA2G17622g CAALFM_C403330WA Ortholog of S. cerevisiae/S. pombe Ipk1; an inositol pentakisphosphate 2-kinase, a nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate; Spider biofilm induced CAALFM_C403340CA Protein with homology to NADH dehydrogenase; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C403350CA Has domain(s) with predicted flavin adenine dinucleotide binding, oxidoreductase activity and role in oxidation-reduction process CAALFM_C403360CA Putative polyphosphate synthetase; decreased expression in hyphae compared to yeast-form cells; fungal-specific (no human or murine homolog); virulence-group-correlated expression CAALFM_C403370CA Ortholog of C. parapsilosis CDC317 : CPAR2_403360, Debaryomyces hansenii CBS767 : DEHA2D00814g, Pichia stipitis Pignal : PICST_32156 and Candida guilliermondii ATCC 6260 : PGUG_04611 CAALFM_C403380CA Putative D-amino acid oxidase; rat catheter biofilm induced CAALFM_C403390WA Functional homolog of S. cerevisiae Shr3p, which is a chaperone specific for amino acid permeases; localized to ER; required for wild-type amino-acid responsive hyphal growth and for mouse systemic virulence; regulated by Gcn2p and Gcn4p CAALFM_C403400WA Protein of unknown function; Hap43-repressed gene CAALFM_C403410WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C403430WA Ortholog of S. cerevisiae Moh1, essential for staionary phase growth; induced by alpha pheromone in SpiderM medium and by Mnl1 under weak acid stress; possibly essential (UAU1 method); flow model biofilm induced; Spider biofilm induced CAALFM_C403440CA Protein similar to ubiquitin C-terminal hydrolase; localizes to cell surface of hyphal cells, but not yeast-form cells; repressed upon high-level peroxide; Hap43p-induced; rat catheter biofilm induced CAALFM_C403450CA Component of the COP9 signalosome (CSN) complex, provides catalytic activity for deneddylation that cleaves the ubiquitin-like protein tag Rub1p off the cullin (Cdc53p) molecule CAALFM_C403460CA Putative protein of unknown function; transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced CAALFM_C403470CA Candidalysin, cytolytic peptide toxin essential for mucosal infection; hypha-specific protein; regulated by Rfg1, Nrg1, Tup1, Cph1, Efg1, Hog1, farnesol, phagocytosis; fluconazole-induced; rat catheter and Spider biofilm induced CAALFM_C403480CA Ortholog of C. dubliniensis CD36 : Cd36_43270 and Candida albicans WO-1 : CAWG_03460 CAALFM_C403490CA Ortholog of Candida albicans WO-1 : CAWG_03459 CAALFM_C403500CA Protein of unknown function; regulated by Tsa1, Tsa1B in minimal media at 37 degrees C CAALFM_C403510CA GPI-anchored, glycosylated cell wall protein; required for biofilm formation, adhesion, filamentous growth on some media; expressed in hyphae; mutant delayed in virulence; regulated by Efg1, Tup1; similar to Hwp1 and Rbt1 domains CAALFM_C403520CA Cell wall protein with similarity to Hwp1; required for virulence; predicted glycosylation; fluconazole, Tup1 repressed; farnesol, alpha factor, serum, hyphal and alkaline induced; Rfg1, Rim101-regulated CAALFM_C403530WA Ortholog of Candida albicans WO-1 : CAWG_03455 CAALFM_C403540CA Putative gamma-glutamyltransferase; alkaline upregulated; Spider biofilm induced; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C403550WA Ortholog of S. cerevisiae Rad2, a nucleotide excision repair nuclease; null mutant is extremely sensitive to UV irradiation; transcript induced by interaction with macrophages CAALFM_C403560WA Phosphorylated protein of unknown function; Hap43p-repressed gene CAALFM_C403570WA Hyphal cell wall protein; host transglutaminase substrate; opaque-, a-specific, alpha-factor induced; at MTLa side of conjugation tube; virulence complicated by URA3 effects; Bcr1-repressed in RPMI a/a biofilms; Spider biofilm induced CAALFM_C403580WA Ortholog of C. dubliniensis CD36 : Cd36_43350, C. parapsilosis CDC317 : CPAR2_403560, Debaryomyces hansenii CBS767 : DEHA2A08250g and Pichia stipitis Pignal : PICST_29838 CAALFM_C403590CA Protein required for wild-type filamentation; has oxysterol binding protein domain and pleckstrin homology motif; overproducton suppresses cph1 homozygous null filamnetation defect; similar to S. cerevisiae Osh3p CAALFM_C403600CA Protein of unknown function; planktonic growth-induced gene CAALFM_C403620CA Transporter of the Pdr/Cdr family of the ATP-binding cassette superfamily; transports phospholipids out-to-in; expressed in opaque-phase cells; induced by macrophage interaction; fluconazole-repressed; Spider biofilm induced CAALFM_C403670WA Ortholog(s) have role in ascospore wall assembly CAALFM_C403680CA Ortholog(s) have role in nucleotide-excision repair and nucleus localization CAALFM_C403690CA Ortholog of C. dubliniensis CD36 : Cd36_43290, C. parapsilosis CDC317 : CPAR2_403630, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114295 and Debaryomyces hansenii CBS767 : DEHA2G17336g CAALFM_C403700WA Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS) CAALFM_C403710CA Predicted membrane protein; rat catheter biofilm induced CAALFM_C403720CA Ortholog(s) have cytosol, nucleus localization CAALFM_C403730CA Ortholog(s) have tRNA (guanine-N1-)-methyltransferase activity, role in mitochondrial tRNA methylation, tRNA N1-guanine methylation and mitochondrial matrix, nucleus localization CAALFM_C403740WA Ortholog(s) have role in U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_C403750CA Ortholog(s) have translation release factor activity, role in mitochondrial translational termination and mitochondrial inner membrane localization CAALFM_C403760WA Ortholog of C. dubliniensis CD36 : Cd36_43500, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_64619, Candida tropicalis MYA-3404 : CTRG_00335 and Candida albicans WO-1 : CAWG_03437 CAALFM_C403770WA Ortholog(s) have protein binding, bridging activity, role in proteasome regulatory particle assembly and cytoplasm, nucleus, ribosome localization CAALFM_C403780CA Putative mitochondrial membrane protein; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media CAALFM_C403790WA Putative 26S proteasome subunit; Hap43p-induced gene; regulated by Gcn2p and Gcn4p CAALFM_C403800CA Ortholog(s) have structural constituent of nuclear pore activity CAALFM_C403810WA Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in CVT pathway, early endosome to Golgi transport, macroautophagy, mitophagy and endosome, extrinsic component of membrane, pre-autophagosomal structure localization CAALFM_C403820CA Protein of unknown function; mutants are viable; rat catheter and Spider biofilm induced CAALFM_C403830WA Predicted tRNA (guanine) methyltransferase activity; Spider biofilm induced CAALFM_C403840CA Putative exosome non-catalytic core component; involved in 3'-5' RNA processing; rat catheter biofilm induced CAALFM_C403850WA Ortholog(s) have nucleocytoplasmic transporter activity, phospholipid binding, single-stranded DNA binding activity and role in mRNA export from nucleus in response to heat stress, nuclear pore organization CAALFM_C403860CA Ortholog of C. dubliniensis CD36 : Cd36_43600, C. parapsilosis CDC317 : CPAR2_403780, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93767 and Debaryomyces hansenii CBS767 : DEHA2G16984g CAALFM_C403880WA Ortholog of C. dubliniensis CD36 : Cd36_43610, C. parapsilosis CDC317 : CPAR2_403770, Debaryomyces hansenii CBS767 : DEHA2G16962g and Pichia stipitis Pignal : PICST_30926 CAALFM_C403890WA Predicted protein tyrosine phosphatase; involved in regulation of MAP kinase Hog1 activity; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced CAALFM_C403900CA Protein that acts in prenylation; transcription is alpha-factor induced; regulated in response to lovastatin and fluconazole; Hap43p-repressed gene CAALFM_C403910WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C403920WA Ortholog(s) have clathrin binding activity, role in clathrin-mediated endocytosis, histone H2B ubiquitination and Dsc E3 ubiquitin ligase complex, clathrin-coated vesicle localization CAALFM_C403930CA Ortholog(s) have 7S RNA binding activity, role in SRP-dependent cotranslational protein targeting to membrane, translocation and nucleolus, signal recognition particle, endoplasmic reticulum targeting localization CAALFM_C403940CA Putative pyruvate carboxylase; binds biotin cofactor; repressed by Ssk1 response regulator, by benomyl treatment, or in an azole-resistant strain overexpressing MDR1; stationary phase enriched protein; flow model biofilm repressed CAALFM_C403950CA Protein of unknown function CAALFM_C403960WA Protein of unknown function; ORF added to Assembly 21 based on comparative genome analysis; protein detected by mass spec in stationary phase cultures CAALFM_C403990CA Predicted ORF in the Major Repeat Sequence on chromosome 4; member of a family encoded by FGR6-related genes in the RB2 repeat sequence CAALFM_C404000WA Putative transcription coactivator; predicted role in sulfur amino acid metabolism; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C404010WA Ortholog of C. dubliniensis CD36 : Cd36_43850, C. parapsilosis CDC317 : CPAR2_402060, Pichia stipitis Pignal : PICST_68242, Candida tropicalis MYA-3404 : CTRG_00303 and Candida albicans WO-1 : CAWG_03390 CAALFM_C404020CA Protein of unknown function; induced by Rgt1 CAALFM_C404030WA Dicarboxylic acid transporter; regulated by glucose repression; induced by Rgt1; disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced CAALFM_C404040WA Ortholog of C. dubliniensis CD36 : Cd36_43820 and Candida albicans WO-1 : CAWG_03393 CAALFM_C404050CA GPI-anchored yeast-associated cell wall protein; induced in high iron; clade-associated gene expression; not essential for cell wall integrity; fluconazole-repressed; flow model and Spider biofilm repressed CAALFM_C404070CA GPI-anchored protein of cell wall CAALFM_C404080CA Cell wall protein; putative GPI anchor; expression regulated upon white-opaque switch; induced by Congo Red and cell wall regeneration; Bcr1-repressed in RPMI a/a biofilms CAALFM_C404090CA Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; caspofungin induced CAALFM_C404100CA Putative pre-ribosomal factor; decreased mRNA abundance observed in cyr1 homozygous mutant hyphae; induced by heavy metal (cadmium) stress; Hog1p regulated CAALFM_C404110WA Protein of unknown function CAALFM_C404120CA Ortholog(s) have phosphatidylinositol-3-phosphate binding, phosphatidylinositol-5-phosphate binding activity CAALFM_C404130WA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and integral component of mitochondrial inner membrane localization CAALFM_C404140WA Protein with a predicted endonuclease/exonuclease/phosphatase family domain and a carbon catabolite repressor protein 4 domain; induced by alpha pheromone in SpiderM medium CAALFM_C404150CA Putative pyruvate dehydrogenase; fluconazole-induced; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C404160WA Ortholog of C. dubliniensis CD36 : Cd36_43710, C. parapsilosis CDC317 : CPAR2_402940, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114940 and Debaryomyces hansenii CBS767 : DEHA2C09196g CAALFM_C404170CA Ortholog of S. cerevisiae Axl2; a plasma membrane protein involved in determination of budding pattern; O-glycosylated by Pmt4; mutant is viable CAALFM_C404180CA Ortholog(s) have role in phospholipid biosynthetic process and endoplasmic reticulum localization CAALFM_C404190CA Ortholog of C. parapsilosis CDC317 : CPAR2_402120, C. dubliniensis CD36 : Cd36_43870, Lodderomyces elongisporus NRLL YB-4239 : LELG_04437 and Candida orthopsilosis Co 90-125 : CORT_0E02170 CAALFM_C404200CA Protein of unknown function; repressed by Sfu1; Hap43-induced gene CAALFM_C404210CA Subunit of the RNA polymerase II mediator complex; involved in control of cytokinesis, morphogenesis, biofilm formation, virulence; cell-cycle regulated periodic mRNA expression CAALFM_C404220WA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C404230WA Putative transporter; fungal-specific; Spider biofilm induced CAALFM_C404240CA Ortholog of S. cerevisiae Skg6; localizes to the cell cortex, cell bud neck, cell bud tip, incipient cellular bud site, and is membrane-bound; Spider biofilm induced CAALFM_C404250WA Predicted membrane transporter, member of the oxalate:formate antiporter (OFA) family, major facilitator superfamily (MFS) CAALFM_C404260CA Mitochondrial biogenesis protein; rat catheter and Spider biofilm induced CAALFM_C404270WA Ortholog(s) have ureidoglycolate lyase activity and cytosol, nucleus localization CAALFM_C404280CA Ortholog(s) have protein binding, bridging activity, role in vesicle-mediated transport and cytosol, nucleus localization CAALFM_C404290WA Exocyst subunit, involved in polarized growth; cellular bud tip-associated protein; interacts with Ras-related GTPase Rsr1p; ortholog of S. cerevisiae SEC15 CAALFM_C404300CA Ortholog of C. dubliniensis CD36 : Cd36_43970, C. parapsilosis CDC317 : CPAR2_401720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_102588 and Debaryomyces hansenii CBS767 : DEHA2G16698g CAALFM_C404310WA Cytochrome oxidase assembly protein; transcript regulated by Nrg1; protein repressed during the mating process; Hap43-repressed gene; rat catheter biofilm induced CAALFM_C404320WA Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; Tup1, Rim101, Ssn6, Hog1, caspofungin repressed; ciclopirox olamine induced; rat catheter biofilm induced CAALFM_C404330CA Protein of unknown function; transcript is upregulated in an RHE model of oral candidiasis; Hap43-repressed CAALFM_C404340CA Frataxin; may be required for iron storage or delivery; role in oxidative stress resistance; transcript regulated by Nrg1, repressed if iron absent induced by macrophage interaction; Hap43-repressed gene CAALFM_C404350WA Ortholog of C. dubliniensis CD36 : Cd36_44020, C. parapsilosis CDC317 : CPAR2_302330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105448 and Debaryomyces hansenii CBS767 : DEHA2C10582g CAALFM_C404360WA Putative cytochrome P450; Hap43-repressed gene CAALFM_C404370CA Ortholog of S. cerevisiae Vac7; integral vacuolar membrane protein involved in vacuole inheritance and morphology; mutants are viable CAALFM_C404380CA Protein of unknown function; Spider biofilm induced CAALFM_C404390WA Ribosomal 60S subunit protein L22B; Spider biofilm repressed CAALFM_C404400CA Protein of unknown function; Spider biofilm induced CAALFM_C404410CA Homoaconitase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-AT); induced by human whole blood or PMNs; Hap43-repressed; flow model and Spider biofilm repressed CAALFM_C404420WA SUMO E3 ligase for Wor1, involved in CO2-mediated white-opaque phenotypic switching; mutations affect filamentous growth; lacks an ortholog in S. cerevisiae CAALFM_C404430WA Mitochondrial ribosomal protein; ortholog of S. cerevisiae Mrp8; transcript induced in hyphal form; mutant is viable; flow model and rat catheter biofilm repressed CAALFM_C404440WA Ortholog(s) have protein transporter activity, role in filamentous growth, posttranslational protein targeting to membrane, translocation and Sec62/Sec63 complex localization CAALFM_C404450CA Putative protein serine/threonine kinase; predicted role in vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; Spider biofilm induced CAALFM_C404460CA Putative serine/threonine kinase similar to S. cerevisiae Sak1; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C404470WA Secreted aspartyl protease; roles in adhesion, virulence (RHE model), cell surface integrity; distinct specificity from Sap9; at cell membrane and wall; GPI-anchored; induced in low iron; Tbf1-activated; Spider biofilm induced CAALFM_C404480CA Translation elongation factor EF-1 beta; repressed by human whole blood or PMNs; macrophage/pseudohyphal-induced; antigenic in mouse; farnesol-downregulated; snoRNA snR18 is encoded within the EFB1 intron; Spider biofilm repressed CAALFM_C404500CA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine trimethylation and cytoplasm localization CAALFM_C404510WA Putative DNA-binding transcription factor; decreased transcription is observed upon fluphenazine treatment; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-induced gene CAALFM_C404520WA Ortholog(s) have enzyme activator activity, telomerase inhibitor activity, role in box C/D snoRNA 3'-end processing, negative regulation of telomere maintenance via telomerase and nucleolus, nucleoplasm localization CAALFM_C404530CA Cell surface glycosidase; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; role in systemic, not vaginal virulence (neutral, not low pH); high pH or filamentation induced; Bcr1-repressed in RPMI a/a biofilm CAALFM_C404550CA Ortholog(s) have metalloendopeptidase activity, role in misfolded or incompletely synthesized protein catabolic process and mitochondrial inner membrane localization CAALFM_C404560CA Predicted transmembrane protein with a role in cell wall polymer composition; Plc1-regulated; Spider biofilm induced CAALFM_C404570WA Putative Type II CAAX prenyl protease; induced during the mating process CAALFM_C404580WA Nonessential protein; similar to S. cerevisiae Zds1p CAALFM_C404590WA Putative ceramide hydroxylase; regulated by Nrg1; induced in high iron; fluconazole-induced; Hap43-repressed; Spider biofilm induced CAALFM_C404600CA Ortholog of C. dubliniensis CD36 : Cd36_44290, C. parapsilosis CDC317 : CPAR2_500740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_137302 and Debaryomyces hansenii CBS767 : DEHA2F07326g CAALFM_C404620CA Protein with DNA binding domain, an endonuclease domain; adjacent to CEN4, the centromere region of Chr 4; clade-associated gene expression CAALFM_C404630CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C404640CA Protein required for respiratory growth, resistance to oxidants, chlamydospore formation, hyphal growth under some conditions, and virulence; relocalizes from the cytoplasm to the mitochondrion during oxidative or osmotic stress CAALFM_C404650WA Ortholog(s) have cytoplasm, nucleolus localization CAALFM_C404660CA Ortholog(s) have ubiquitin-specific protease activity and role in protein deubiquitination CAALFM_C404670CA Ortholog of C. dubliniensis CD36 : Cd36_44340, C. parapsilosis CDC317 : CPAR2_302240, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105331 and Debaryomyces hansenii CBS767 : DEHA2E03454g CAALFM_C404700WA Putative HSP70 chaperone; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C404710WA Putative Cis-golgi GTPase-activating protein; required for hyphen growth and virulence; transcript regulated by Nrg1, Mig1, and Tup1 CAALFM_C404720WA Ortholog(s) have methylenetetrahydrofolate dehydrogenase (NAD+) activity, role in folic acid-containing compound biosynthetic process, one-carbon metabolic process, purine nucleobase biosynthetic process and cytosol, nucleus localization CAALFM_C404730WA Putative Myb-like transcription factor; ortholog S. cerevisiae Bas1, a regulator of purine biosynthetic genes; mutant exhibits adenine auxotrophy and abnormal colony morphology CAALFM_C404750WA Ortholog(s) have role in negative regulation of gluconeogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process, traversing start control point of mitotic cell cycle and GID complex, cytoplasm, nucleus localization CAALFM_C404760CA Protein of unknown function; filament induced CAALFM_C404770CA Alpha-1,2-mannosyltransferase; required for normal cell wall mannan; regulated by Tsa1, Tsa1B at 37 deg; repressed in core stress response; NO, Hog1 induced; confers sensitivity to cell wall perturbing agents; Spider biofilm repressed CAALFM_C404780WA Protein mannosyltransferase; required for virulence in mice, adhesion to endothelium; role in hyphal growth signaling, hygromycin B sensitivity; no major role in cellular PMT activity; Hap4-repressed; Bcr1-repressed in RPMI a/a biofilms CAALFM_C404790WA Protein with weak similarity to S. cerevisiae Fus2p; induced by alpha pheromone mating factor in MTLa/MTLa opaque cells CAALFM_C404800WA Ortholog(s) have role in endoplasmic reticulum tubular network maintenance, nuclear pore complex assembly and Golgi apparatus, cortical endoplasmic reticulum, integral component of endoplasmic reticulum membrane, mitochondrion localization CAALFM_C404810CA Ortholog(s) have tRNA (guanine-N7-)-methyltransferase activity, role in tRNA methylation and nucleolus, tRNA methyltransferase complex localization CAALFM_C404820CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C404830WA Putative Dicer RNAse involved in RNA interference, similar to S. cerevisiae Rnt1p but orthologous to S. castellii Dcr1p, which is not conserved in S. cerevisiae CAALFM_C404840CA Putative serine transporter; possible role in assimilation of sulfur; F-12/CO2 early biofilm induced CAALFM_C404850CA Transcription factor; role in zinc homeostasis and regulation of Spider biofilm matrix; mutation affects filamentous growth; can suppress S. cerevisiae rok1 mutant inviability; Spider biofilm induced; mutants for abnormal Spider biofilms CAALFM_C404860WA Protein of unknown function; mRNA binds She3; regulated by Nrg1; upregulated in a cyr1 or ras1 mutant CAALFM_C404870CA Ortholog(s) have chromatin binding, mRNA binding activity CAALFM_C404880WA Putative asparaginase; lacks ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Spider biofilm induced CAALFM_C404890CA Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR; Hap43-induced; Spider biofilm repressed CAALFM_C404900WA Ribosomal 60S subunit protein; pre-rRNA processing; pre-mRNA alternatively spliced to productive/unproductive transcripts; temp-regulated splicing; colony morphology-related regulation by Ssn6, Tup1, Nrg1 regulated; Spider biofilm repressed CAALFM_C404910CA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_C404920WA Ortholog(s) have chromatin DNA binding activity and role in positive regulation of transcription from RNA polymerase II promoter, tRNA modification, tRNA threonylcarbamoyladenosine metabolic process, telomere maintenance via recombination CAALFM_C404930CA DnaJ chaperone domain protein; role in pre-mRNA splicing; Spider biofilm induced CAALFM_C404950WA Protein of unknown function; rat catheter biofilm induced CAALFM_C404970CA Ortholog(s) have role in cristae formation and MICOS complex, mitochondrial crista junction localization CAALFM_C404980WA Predicted membrane transporter; member of the peptide-acetyl-coA transporter (PAT) family, major facilitator superfamily (MFS); induced by alpha pheromone in Spider medium CAALFM_C404990CA Protein of unknown function; Hap43-repressed; Spider biofilm induced CAALFM_C405000WA Protein likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C405010WA Protein with a predicted role in ribosome biogenesis; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); repressed in core stress response; repressed by prostaglandins; Hap43-induced CAALFM_C405020WA Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced CAALFM_C405030CA MAP kinase kinase kinase (MAPKKK); regulates Hog1 activation and signaling; repressed by ciclopirox olamine CAALFM_C405040WA Ortholog(s) have protein tag activity, role in cell morphogenesis involved in conjugation with cellular fusion, cellular protein modification process, mRNA splicing, via spliceosome and mating projection localization CAALFM_C405050CA Protein phosphatase of the Type 2A-related family (serine/threonine-specific) involved in control of filamentous growth and virulence CAALFM_C405060WA Putative RNAse III, ortholog of S. cerevisiae RNT1; merged with orf19.3772 in Assembly 21 CAALFM_C405070CA Putative acetylornithine aminotransferase; Gcn2, Gcn4 regulated; rat catheter biofilm induced; Spider biofilm induced CAALFM_C405080CA Ortholog(s) have zinc ion transmembrane transporter activity, role in zinc II ion transport and endoplasmic reticulum localization CAALFM_C405090CA Putative RNA polymerase II mediator complex subunit; early-stage flow model biofilm induced CAALFM_C405100CA Class I myosin; nonessential; role in cortical actin patch polarity and polar budding; required for hyphal growth, white-opaque switch; regulatory phosphorylation on S366; downregulated on adherence to polystyrene CAALFM_C405110CA Putative Hap4-like transcription factor; Hap43-repressed; not required for response to low iron; induced by Mnl1 under weak acid stress; Spider biofilm induced CAALFM_C405130CA Putative aldehyde dehydrogenase; stationary phase enriched protein; expression regulated upon white-opaque switch; rat catheter biofilm induced; rat catheter and Spider biofilm induced CAALFM_C405140CA Putative glycogen debranching enzyme; expression is regulated upon white-opaque switch; regulated by Nrg1, Tup1; rat catheter biofilm repressed CAALFM_C405150WA Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats CAALFM_C405160CA Has domain(s) with predicted role in protein transport, vacuolar transport CAALFM_C405180CA Ortholog(s) have RNA binding, nucleocytoplasmic transporter activity, structural constituent of nuclear pore activity CAALFM_C405190CA Ortholog(s) have mRNA binding activity CAALFM_C405200CA Ortholog of C. dubliniensis CD36 : Cd36_44860, Candida tropicalis MYA-3404 : CTRG_04054 and Candida albicans WO-1 : CAWG_03295 CAALFM_C405210WA Ortholog(s) have CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity, role in phosphatidylinositol biosynthetic process and Golgi apparatus, integral component of membrane, mitochondrial outer membrane localization CAALFM_C405220CA Ortholog(s) have ubiquitin-protein transferase activity and role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, chromatin assembly, protein ubiquitination CAALFM_C405230CA Hap43-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C405240CA Vacuolar H(+)-ATPase; transcription regulated by Nrg1, Mig1, and Tup1 CAALFM_C405250WA Putative ubiquitin-protein ligase; role in protein ubiquitination; Spider biofilm induced CAALFM_C405260WA Subunit of Elongator complex; required for modification of wobble nucleosides in tRNA in S. cerevisiae; Hap43-induced gene CAALFM_C405270CA Protein involved in homologous recombination and DNA breaks repair; similar to S. cerevisiae Rad59p; N-terminal similarity with Rad52p CAALFM_C405280WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, Golgi vesicle docking, SNARE complex assembly and ER to Golgi transport vesicle membrane, Golgi membrane localization CAALFM_C405290WA Ortholog(s) have 4-amino-4-deoxychorismate synthase activity, role in para-aminobenzoic acid biosynthetic process and cytosol, nucleus localization CAALFM_C405300WA Putative xylulokinase; Hap43-repressed; induced by prostaglandins; rat catheter biofilm repressed CAALFM_C405310WA Ortholog(s) have mitochondrion localization CAALFM_C405320WA Saccharopine dehydrogenase (biosynthetic); enzyme of alpha-aminoadipate lysine biosynthesis pathway; functionally complements S. cerevisiae lys1 mutation; fungal-specific (no human or murine homolog) CAALFM_C405330CA Putative protein with a predicted role in 60S ribosomal subunit biogenesis; Hap43p-induced gene; ortholog of S. cerevisiae MAK11 CAALFM_C405340WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_C405350WA Ortholog(s) have phosphatidylinositol-3,5-bisphosphate binding activity and role in macroautophagy, piecemeal microautophagy of nucleus CAALFM_C405360CA Ortholog(s) have RNA binding, translation regulator activity and role in Group I intron splicing, mitochondrial respiratory chain complex IV biogenesis, positive regulation of mitochondrial translation CAALFM_C405370WA RNA-binding protein involved in regulation of mitochondrial biogenesis CAALFM_C405380CA Ortholog(s) have role in protein targeting to ER, signal peptide processing and signal peptidase complex localization CAALFM_C405390WA Putative glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; Spider biofilm repressed CAALFM_C405400CA D-arabinose 5-phosphate isomerase; has GutQ domain which is associated with phosphosugar binding; other biofilm induced; rat catheter and Spider biofilm induced; F-12/CO2 early biofilm induced CAALFM_C405420CA Putative GTPase-activating protein; similar to mammalian tuberin; involved in control of filamentous growth; mutants are viable CAALFM_C405430CA Putative general amino acid permease; fungal-specific (no human or murine homolog) CAALFM_C405440CA Protein of unknown function; Spider biofilm induced CAALFM_C405450CA Putative cytochrome B5 reductase; plasma membrane-localized CAALFM_C405460CA Putative prolyl hydroxylase family member; regulates Ume6p stability in response to oxygen; inhibited by hypoxia; repressed by prostaglandins; Spider biofilm induced CAALFM_C405530WA Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth CAALFM_C405540WA Putative L-aspartate 4-P-transferase; fungal-specific (no human or murine homolog); regulated by Gcn2 and Gcn4; early-stage flow model biofilm induced CAALFM_C405550CA BAR domain protein; ocalizes to early and late Golgi vesicles; predicted role in adaptation to varying nutrient concentrations, fluid-phase endocytosis, actin cytoskeleton polarization and vacuole biogenesis; rat catheter biofilm repressed CAALFM_C405560CA Aromatic transaminase; Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101-dependent pH-regulation (alkaline induced); Hap43-induced gene CAALFM_C405570CA Putative gamma-tubulin; induced upon adherence to polystyrene; transcript regulated by Nrg1 and Mig1; periodic mRNA expression, peak at cell-cycle S/G2 phase CAALFM_C405580CA Secreted protein; exogenously expressed protein is a substrate for Kex2 processing in vitro; fluconazole-regulated; Spider biofilm induced CAALFM_C405590WA Ortholog of S. cerevisiae : YPR117W, C. glabrata CBS138 : CAGL0D04510g, C. dubliniensis CD36 : Cd36_45200, C. parapsilosis CDC317 : CPAR2_500480 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_120679 CAALFM_C405600WA Ortholog(s) have GTPase activator activity, role in intracellular protein transport and cytoplasm localization CAALFM_C405610CA Putative eisosome component role in proper eisosome assembly; upregulated in cyr1 null mutant CAALFM_C405620CA Ortholog of C. dubliniensis CD36 : Cd36_45230, C. parapsilosis CDC317 : CPAR2_500450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103249 and Debaryomyces hansenii CBS767 : DEHA2C07524g CAALFM_C405630WA Putative RNA polymerase II subunit B44; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm repressed CAALFM_C405640CA Ortholog(s) have 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, role in histidine biosynthetic process and cytosol, nucleus localization CAALFM_C405650WA Ortholog(s) have role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and cytoplasm, nucleolus localization CAALFM_C405660CA Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression CAALFM_C405670WA Ortholog(s) have ATP-dependent peptidase activity CAALFM_C405680WA bHLH transcription factor of the myc-family; required for growth in medium lacking phosphate and for resistance to copper and Phloxine B; induced by Mnl1 under weak acid stress CAALFM_C405690WA Putative GTPase-activating protein; regulated upon yeast-hypha switch; Spider biofilm repressed CAALFM_C405700WA Zn(II)2Cys6 transcription factor; colony morphology-related gene regulation by Ssn6 CAALFM_C405730WA Adhesin-like protein; regulated by Tsa1, Tsa1B in minimal media at 37 deg; clade-associated gene expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider biofilm repressed CAALFM_C405740CA Ortholog(s) have DNA binding, ubiquitin-protein transferase activity and role in histone catabolic process, histone ubiquitination, regulation of transcription from RNA polymerase II promoter in response to oxidative stress CAALFM_C405750CA Predicted component of U2 snRNP; induced by alpha pheromone in SpiderM medium CAALFM_C405760WA mRNA 5' guanylyltransferase; small subunit of mRNA capping enzyme; binds an RNA Pol II C-terminal domain peptide; Cet1p and Cgt1p form a 2:1 complex; functional homolog of S. cerevisiae Ceg1p CAALFM_C405770CA Protein similar to ferric reductase Fre10p; possible functional homolog of S. cerevisiae Fre1p (reports differ); transcription is negatively regulated by Sfu1p, copper, amphotericin B, caspofungin; induced by ciclopirox olamine CAALFM_C405780CA Oxidoreductase; iron utilization; Sfu1/Sef1/Hap43/Nrg1/Tup1/Rim101 regulated; alkaline/low iron/fluphenazine/ciclopirox olamine, flucytosine, fluconazole, Spider/flow model/rat catheter biofilm induced; caspofungin/amphotericin B repressed CAALFM_C405790WA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity and role in CVT pathway, early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, macroautophagy, regulation of GTPase activity CAALFM_C405800CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C405810WA Ortholog of S. cerevisiae : CAJ1, C. glabrata CBS138 : CAGL0L00957g, C. dubliniensis CD36 : Cd36_45380, C. parapsilosis CDC317 : CPAR2_500650 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_132273 CAALFM_C405820WA Ortholog(s) have cysteine desulfurase activity, role in iron-sulfur cluster assembly and L-cysteine desulfurase complex, extrinsic component of mitochondrial inner membrane, mitochondrial matrix localization CAALFM_C405830WA Protein of unknown function; transcript detected on high-resolution tiling arrays; rat catheter biofilm induced CAALFM_C405840WA Protein with similarity to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C405850CA Protein of unknown function; may play a role in regulation of cell size; rat catheter biofilm repressed CAALFM_C405860WA Ortholog(s) have tubulin binding activity, role in positive regulation of transcription elongation from RNA polymerase II promoter, tubulin complex assembly and cytoplasm, prefoldin complex localization CAALFM_C405870CA Has domain(s) with predicted DNA binding, zinc ion binding activity, role in transcription, DNA-templated and nucleus localization CAALFM_C405880WA GATA-type transcription factor; regulator of nitrogen utilization; required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan N sources; required for virulence in a mouse systemic infection model CAALFM_C405890WA Protein with a selenoprotein domain and a thioredoxin-like fold domain; similar to S. cerevisiae Vhs3p, which is a putative phosphopantothenoylcysteine decarboxylase CAALFM_C405900CA Protein of unknown function; Rgt1, Hap43-repressed; flow model biofilm induced; Spider biofilm induced CAALFM_C405910CA Protein involved in protein trafficking; putative role in vesicle-target membrane fusion; mutant lacks vacuole; role in hyphal growth, possibly via vacuole expansion into hypha; role in killing of and survival within macrophage CAALFM_C405920CA Putative GPI-anchored protein CAALFM_C405940WA Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p; mutant shows virulence defect CAALFM_C405960WA Protein of unknown function; ortholog of S. cerevisiae Nif3; rat catheter biofilm repressed CAALFM_C405970WA Protein of unknown function; Hap43-repressed gene CAALFM_C405980CA Ortholog(s) have nucleoside-triphosphatase activity, nucleoside-triphosphate diphosphatase activity and role in cellular response to phosphate starvation, nucleoside triphosphate metabolic process CAALFM_C406000WA Protein similar to S. cerevisiae Alg1p, a mannosyltransferase involved in N-linked protein glycosylation; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C406010CA Histone deacetylase; similar to S. cerevisiae Hos1; has conserved deacetylation motif; slightly greater expression in white cells than in opaque cells CAALFM_C406020CA Ortholog(s) have DNA-directed DNA polymerase activity, deoxycytidyl transferase activity and role in error-free translesion synthesis, error-prone translesion synthesis CAALFM_C406030WA Calmodulin; calmodulin inhibitors cause a defect in hyphal growth; transcript not regulated by yeast-hyphal transition; mutation confers hypersensitivity to cytochalasin D and high concentrations of tunicamycin; gene has intron CAALFM_C406040WA Ortholog of C. dubliniensis CD36 : Cd36_45590, C. parapsilosis CDC317 : CPAR2_501450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105024 and Debaryomyces hansenii CBS767 : DEHA2D12364g CAALFM_C406050WA RNA polymerase II mediator complex subunit CAALFM_C406060WA Putative vacuolar protein sorting-associated protein; gene used for multilocus sequence typing CAALFM_C406070CA Putative methionyl-tRNA transformylase; induced upon adherence to polystyrene CAALFM_C406080WA Ortholog of C. parapsilosis CDC317 : CPAR2_501415, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105081, Debaryomyces hansenii CBS767 : DEHA2D12298g and Pichia stipitis Pignal : psti_CGOB_00211 CAALFM_C406090CA Predicted component of the core factor rDNA transcription factor complex; required for transcription of 35S rRNA genes by RNA polymerase I in S. cerevisiae; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C406100WA Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan; rat catheter biofilm repressed CAALFM_C406110CA Predicted tryptophan synthase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; Gcn4p-regulated; S. cerevisiae ortholog is Gcn4p regulated; upregulated in biofilm CAALFM_C406120WA NADP-glutamate dehydrogenase; Nrg1, Plc1 regulated; hypha, hypoxia, Efg1-repressed; Rim101-induced at pH 8; GlcNAc, ciclopirox, ketoconazole induced; exp and stationary phase protein; Spider biofilm repressed; rat catheter biofilm induced CAALFM_C406130WA Ortholog(s) have tubulin binding activity and role in microtubule cytoskeleton organization, mitochondrial fission, mitochondrion inheritance, nuclear migration along microtubule CAALFM_C406140CA Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, MFS superfamily; induced by alpha pheromone in SpiderM medium CAALFM_C406150CA Ortholog(s) have double-stranded DNA binding activity, role in reciprocal meiotic recombination, synapsis and condensed nuclear chromosome localization CAALFM_C406160WA Ortholog(s) have alpha-tubulin binding activity and role in protein folding, tubulin complex assembly CAALFM_C406170CA Ortholog(s) have role in ribosome biogenesis and cytosol, ribosome localization CAALFM_C406190CA Protein similar to S. cerevisiae Mph1p, which is a DNA helicase involved in DNA repair; induced under hydroxyurea treatment CAALFM_C406200WA Ortholog of C. parapsilosis CDC317 : CPAR2_401885, Pichia stipitis Pignal : psti_CGOB_00141, Candida orthopsilosis Co 90-125 : CORT_0E01925 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00016 CAALFM_C406210CA Putative GTPase; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Hap43p-induced gene CAALFM_C406220CA Ortholog of C. dubliniensis CD36 : Cd36_45740, C. parapsilosis CDC317 : CPAR2_401900, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116046 and Pichia stipitis Pignal : PICST_28890 CAALFM_C406230CA Ortholog(s) have nucleoside-diphosphatase activity, nucleoside-triphosphatase activity, role in protein glycosylation and COPI-coated vesicle, Golgi membrane localization CAALFM_C406240WA Ortholog of C. dubliniensis CD36 : Cd36_45760, C. parapsilosis CDC317 : CPAR2_401920, Candida tenuis NRRL Y-1498 : CANTEDRAFT_126814 and Debaryomyces hansenii CBS767 : DEHA2D16742g CAALFM_C406250CA Predicted subunit of the exocyst complex, involved in exocytosis; required for hyphal growth after the first septin ring formation; interacts with septins Cdc3p, Cdc10p, and Cdc11p; localizes to a crescent on the surface of the hyphal tip CAALFM_C406260WA Putative GPI-anchored protein CAALFM_C406270CA C-3 sterol dehydrogenase, catalyzes the 2nd of 3 steps required to remove 2 C-4 methyl groups from an intermediate in ergosterol biosynthesis; amphotericin B, caspofungin repressed; Spider biofilm repressed CAALFM_C406280CA Predicted oxidoreductase; rat catheter biofilm induced CAALFM_C406290WA Ortholog(s) have chromatin DNA binding activity and role in positive regulation of transcription from RNA polymerase II promoter by pheromones, tRNA threonylcarbamoyladenosine metabolic process, telomere maintenance via recombination CAALFM_C406300CA Putative GPI-anchored adhesin-like protein; decreased transcription is observed in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1 CAALFM_C406310CA Putative GPI-anchored protein; adhesin-like protein CAALFM_C406340WA Putative Argonaute protein involved in RNA silencing; hyphal-induced expression; regulated by Cyr1, Ras1, Efg1, Nrg1, Tup1; rat catheter biofilm repressed CAALFM_C406350CA Ortholog of S. cerevisiae Nup60p; a subunit of the nuclear pore complex; mutants are viable CAALFM_C406360CA Ortholog of C. parapsilosis CDC317 : CPAR2_500750, C. dubliniensis CD36 : Cd36_45850, Pichia stipitis Pignal : PICST_43336 and Candida orthopsilosis Co 90-125 : CORT_0B00900 CAALFM_C406370CA Ortholog(s) have borate efflux transmembrane transporter activity, role in borate transport, protein targeting to vacuole and fungal-type vacuole, plasma membrane localization CAALFM_C406380WA Protein similar to Sou1; not required for utilization of L-sorbose; Spider biofilm induced CAALFM_C406390WA Enzyme involved in utilization of L-sorbose; has sorbitol dehydrogenase, fructose reductase, and sorbose reductase activities; NAD-binding site motif; transcriptional regulation affected by chromosome 5 copy number; Hap43p-induced gene CAALFM_C406400CA Putative vacuolar H+-ATPase subunit; regulated by Nrg1 and Mig1; transcript increases in populations of cells exposed to fluconazole over multiple generations; rat catheter and Spider biofilm repressed CAALFM_C406410WA Protein of unknown function; regulation correlates with clinical development of fluconazole resistance; transcript is upregulated in an RHE model of oral candidiasis CAALFM_C406420WA Ortholog of C. dubliniensis CD36 : Cd36_45910, C. parapsilosis CDC317 : CPAR2_501110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119393 and Debaryomyces hansenii CBS767 : DEHA2E08976g CAALFM_C406430CA Ortholog(s) have role in cellular response to oxidative stress, misfolded or incompletely synthesized protein catabolic process, protein import into peroxisome matrix and mitochondrial inner membrane localization CAALFM_C406440CA Has domain(s) with predicted sugar:proton symporter activity, role in carbohydrate transport and Golgi membrane, integral component of membrane localization CAALFM_C406450WA Ortholog(s) have role in chromatin remodeling, regulation of chromosome segregation and Ino80 complex, cytoplasm localization CAALFM_C406460CA Ortholog(s) have role in early endosome to Golgi transport, protein complex assembly and TRAPPII protein complex, clathrin-coated vesicle localization CAALFM_C406470WA Ortholog in S. cerevisiae is localizedto the bud, mating projection tip, and associates with ribosomes; Spider biofilm induced CAALFM_C406480CA ERK-family protein kinase; required for wild-type yeast-hypha switch, mating efficiency, virulence in mice; Cst20-Hst7-Cek1-Cph1 MAPK pathway regulates mating, and invasive hyphal growth under some conditions; Spider biofilm induced CAALFM_C406490CA Putative DNA primase; gene adjacent to and divergently transcribed with CDC68; Hap43-induced; Spider biofilm repressed CAALFM_C406500WA Functional homolog of S. cerevisiae Cdc68, a transcription elongation factor; essential; possible drug target CAALFM_C406510CA Protein of unknown function; Hap43-repressed gene; protein not conserved in S. cerevisiae CAALFM_C406530CA Putative high-affinity, high-capacity xanthine-uric acid/H+ symporter; similar to A. nidulans UapA; member of the Nucleobase-Ascorbate Transporter/Nucleobase-Cation Symporter (NAT/NCS2) family; rat catheter biofilm induced CAALFM_C406540WA Regulator of mannosylphosphorylation of N-linked mannans to cell wall proteins; no role in virulence or normal interaction with macrophages; mutant induces inflammatory cytokines in dendritic cells; rat catheter and Spider biofilm induced CAALFM_C406550CA Putative GPI-anchored protein; adhesin-like protein; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C406560WA Putative GPI-anchored protein CAALFM_C406570CA Pyruvate decarboxylase; antigenic; on hyphal not yeast cell surface; Hap43, Gcn4, Efg1, Efh1, Hsf1 regulated; fluconazole, farnesol induced; amino acid starvation repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C406580WA Transcription factor; binds ribosomal protein gene promoters and rDNA locus with Tbf1; regulates sulfur starvation-response, respiratory, glycolytic genes; does not bind to centromeres as does S. cerevisiae Cbf1; Spider biofilm repressed CAALFM_C406590WA Ortholog of S. pombe SPAC1071.09c DNAJ domain protein; Hap43-induced gene CAALFM_C406600WA DNA topoisomerase II; catalyzes ATP-dependent DNA relaxation and decatenation in vitro; Y842 predicted to be catalytic; functional homolog of S. cerevisiae Top2p; sensitive to amsacrine or doxorubicin; farnesol-upregulated in biofilm CAALFM_C406610CA Succinate dehydrogenase; soluble protein in hyphae; macrophage-downregulated protein level; downregulated by Efg1p; repressed by nitric oxide; protein present in exponential and stationary growth phase yeast cultures; Hap43p-repressed gene CAALFM_C406620CA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C406630CA Ortholog of C. dubliniensis CD36 : Cd36_46110, Candida tropicalis MYA-3404 : CTRG_03792 and Candida albicans WO-1 : CAWG_03165 CAALFM_C406640CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C406650WA Ortholog(s) have phosphatidylinositol-3-phosphate binding, protein transporter activity CAALFM_C406660WA Has domain(s) with predicted DNA binding, nucleic acid binding activity CAALFM_C406670WA Ortholog of C. dubliniensis CD36 : Cd36_46140, C. parapsilosis CDC317 : CPAR2_501210, Candida tenuis NRRL Y-1498 : CANTEDRAFT_97195 and Debaryomyces hansenii CBS767 : DEHA2E08800g CAALFM_C406680CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and cytoplasmic mRNA processing body, endoplasmic reticulum membrane, extrinsic component of membrane localization CAALFM_C406690CA Ortholog(s) have role in cellular response to DNA damage stimulus, proteasome assembly, ubiquitin-dependent protein catabolic process and cytosol, nucleus localization CAALFM_C406710WA Putative NADP-dependent oxidoreductase; Hap43-repressed; induced by benomyl treatment; oxidative stress-induced via Cap1; rat catheter biofilm repressed CAALFM_C406720WA Nucleolar protein; flucytosine induced; Hap43-induced; Spider biofilm repressed CAALFM_C406730CA Ortholog(s) have transcription coactivator activity, role in carbon catabolite regulation of transcription from RNA polymerase II promoter and cytoplasm localization CAALFM_C406740CA Ortholog(s) have protein binding, bridging activity and role in ER-associated ubiquitin-dependent protein catabolic process, lipid particle organization CAALFM_C406760WA Glycerol-3-phosphate dehydrogenase; Plc1p-regulated; rat catheter biofilm induced; Spider biofilm induced CAALFM_C406770WA Predicted endoplasmic reticulum zinc transporter; induced by nitric oxide CAALFM_C406780CA NAD(P)H oxidoreductase family protein; induced by nitric oxide, amphotericin B, oxidative stress via Cap1; upregulation associated with MDR1 overexpression or benomyl treatment; macrophage-downregulated protein; Spider biofilm induced CAALFM_C406790WA Ortholog of S. cerevisiae Gpn3 a GTPase with a role in biogenesis of RNA pol II and polIII; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C406800WA Putative chromatin remodelling complex protein; heterozygous null mutant displays sensitivity to virgineone; Spider biofilm repressed CAALFM_C406810CA Ortholog(s) have syntaxin binding activity and role in ER to Golgi vesicle-mediated transport, positive regulation of SNARE complex assembly, retrograde vesicle-mediated transport, Golgi to ER, vesicle fusion with Golgi apparatus CAALFM_C406820CA Transcription factor; regulates white-opaque switch; hyphal growth regulator; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response; required for yeast cell adherence to silicone; Spider biofilm induced CAALFM_C406830CA Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin D; GlcNAc-induced protein; Spider biofilm repressed CAALFM_C406840WA Ortholog(s) have cytosol, nucleus localization CAALFM_C406850CA Ortholog(s) have mRNA binding, metalloaminopeptidase activity, role in negative regulation of gene expression, protein initiator methionine removal involved in protein maturation and cytosolic ribosome localization CAALFM_C406860CA Ortholog(s) have cytidine deaminase activity, role in cytidine catabolic process, deoxycytidine catabolic process, pyrimidine-containing compound salvage and cytosol, nucleus localization CAALFM_C406870WA 26S proteasome regulatory subunit; transcript regulated by Nrg1 and Mig1; regulated by Gcn2 and Gcn4; protein level decreases in stationary phase CAALFM_C406880CA Ortholog(s) have role in SAGA complex localization to transcription regulatory region, exocytosis, filamentous growth, histone deubiquitination and mRNA export from nucleus, more CAALFM_C406890WA Ortholog of S. cerevisiae Arr3; arsenite transporter of the plasma membrane required for resistance to arsenic compounds; benomyl-induced; Gcn4-regulated; Hap43-repressed; mutant is viable; Spider biofilm induced CAALFM_C406900WA Putative glutathione S-transferase; upregulated in the presence of human neutrophils; expression is regulated upon white-opaque switching; increased transcription is observed upon benomyl treatment CAALFM_C406910WA PDR-subfamily ABC transporter (half-size); similar to WHITE subfamily proteins; repressed by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; induced by nitric oxide; rat catheter biofilm induced CAALFM_C406920CA Extracellular-associated protein; repressed by Rim101 at pH 8; regulated by Tsa1, Tsa1B in minimal media at 37 deg; induced by ketoconazole, nitric oxide, Hap43; required for normal RPMI biofilm formation; Bcr1 induced in RPMI CAALFM_C406930CA Putative U1 snRNP complex compotent; decreased transcription is observed upon fluphenazine treatment CAALFM_C406940CA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C406950WA Predicted pseudouridine synthase; Spider biofilm induced CAALFM_C406960WA Protein of unknown function; Spider biofilm induced CAALFM_C406970CA Putative zinc transporter; acts with Pra1 in sequestration of zinc from host tissues during infection; hyphal, macrophage-induced; alkaline induced upon adherence to polystyrene; induced in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C406980WA Cell surface protein that sequesters zinc from host tissue; enriched at hyphal tips; released extracellularly; binds to host complement regulators; mediates leukocyte adhesion and migration; immunogenic in mouse; produced at ambient pH CAALFM_C406990WA Possible mannosyltransferase; Spider biofilm induced CAALFM_C407000WA Ortholog of C. dubliniensis CD36 : Cd36_46470, C. parapsilosis CDC317 : CPAR2_500900, Debaryomyces hansenii CBS767 : DEHA2B15730g and Candida tropicalis MYA-3404 : CTRG_03755 CAALFM_C407010CA Putative DNA repair methyltransferase; induced by nitric oxide independent of Yhb1; Spider biofilm induced CAALFM_C407020CA Ortholog of C. dubliniensis CD36 : Cd36_46490, Pichia stipitis Pignal : PICST_33598, Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00037 and Candida tropicalis MYA-3404 : CTRG_03758 CAALFM_C407030WA Putative 3'-phosphoadenylsulfate reductase; sulfur amino acid metabolism; reports differ on regulation during biofilm formation; fungal-specific; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene CAALFM_C407040WA Putative cytochrome P450 protein; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C407050WA Alkaline dihydroceramidase; involved in sphingolipid metabolism; Mob2-dependent hyphal regulation; transcript is regulated by Nrg1 and Mig1; Hap43-repressed CAALFM_C407060WA Ortholog(s) have RNA polymerase III activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex localization CAALFM_C407070WA Protein that activates transcription in 1-hybrid assay in S. cerevisiae CAALFM_C407080CA Protein with t-SNARE domains and a microtubule associated domain; Hap43-induced gene; repressed by alpha pheromone in SpiderM medium CAALFM_C407090CA Predicted enzyme of amino acid biosynthesis; upregulated in biofilm; regulated by Gcn2p and Gcn4p; S. cerevisiae ortholog is Gcn4p regulated CAALFM_C407100CA Predicted RNA-dependent ATPase RNA helicase; Hap43-induced gene CAALFM_C407110CA Putative pyruvate dehydrogenase alpha chain; fluconazole-induced; protein present in exponential and stationary growth phase yeast cultures; Hap43-induced; Spider biofilm repressed CAALFM_C407120CA Putative DNA mismatch repair factor; transcript regulated by Nrg1; flucytosine repressed; transcript regulated by tyrosol and cell density CAALFM_C407130WA Protein of unknown function; repressed during core stress response CAALFM_C407140WA Predicted mitochondrial intermembrane space protein; predicted role in phospholipid metabolism; rat catheter and Spider biofilm induced CAALFM_C407150WA bZIP transcription factor; possibly transcriptionally regulated upon hyphal formation; Hap43; F-12/CO2 early biofilm induced; Spider biofilm induced CAALFM_C407160WA Ortholog of C. dubliniensis CD36 : Cd36_26300, Candida tenuis NRRL Y-1498 : cten_CGOB_00015, Debaryomyces hansenii CBS767 : DEHA2G16104g and Pichia stipitis Pignal : psti_CGOB_00212 CAALFM_C407170CA Ortholog of C. dubliniensis CD36 : Cd36_54140 and Candida albicans WO-1 : CAWG_04820 CAALFM_C407180WA Fusion of ubiquitin with the S34 protein of the small ribosomal subunit; mRNA decreases upon heat shock, appears to be degraded; functional homolog of S. cerevisiae RPS31; Hap43-induced; Spider biofilm repressed CAALFM_C407190WA Ortholog(s) have role in Golgi to plasma membrane transport, exocytosis and exocyst, mating projection tip localization CAALFM_C407200CA Putative lipid phosphatase of the endoplasmic reticulum; role in DNA repair, actin cytoskeleton organization, cellular manganese ion homeostasis; Spider biofilm repressed CAALFM_C407210WA Ortholog(s) have histone acetyltransferase activity, role in chromatin silencing at telomere and SAS acetyltransferase complex, nuclear chromatin localization CAALFM_C407220CA Ortholog(s) have role in attachment of mitotic spindle microtubules to kinetochore, cohesin localization to chromatin and establishment of mitotic sister chromatid cohesion, more CAALFM_C407230CA Subunit of the NuA4 histone acetyltransferase complex; soluble protein in hyphae; Spider biofilm repressed CAALFM_C407240WA Ortholog(s) have role in vesicle-mediated transport and COPI-coated vesicle, integral component of Golgi membrane localization CAALFM_C407250CA Member of a family of telomere-proximal genes of unknown function CAALFM_C407260WA Protein of unknown function CAALFM_C500010WA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo CAALFM_C500030WA Putative mitochondrial ribosomal protein of the large subunit; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed CAALFM_C500040CA Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex; removes the GPI-anchor signal and attaches GPI to proteins in the ER; Spider biofilm repressed CAALFM_C500050WA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on transcription data CAALFM_C500060CA Ortholog(s) have ubiquitin-protein transferase activity and role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination CAALFM_C500070WA Septin; cell and hyphal morphology, agar-invasive growth, full virulence and kidney tissue invasion in mouse, but not kidney colonization, immunogenicity; hyphal and cell-cycle-regulated phosphorylation; rat catheter biofilm repressed CAALFM_C500080CA Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; Spider biofilm repressed CAALFM_C500090CA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C500100CA Protein of unknown function; Spider biofilm induced CAALFM_C500110CA Putative threonyl-tRNA synthetase; transcript regulated by Mig1 and Tup1; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed CAALFM_C500120WA Protein of unknown function CAALFM_C500130CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C500140CA Putative integral membrane protein of unknown function; clade-associated gene expression; Spider biofilm induced CAALFM_C500150CA Ortholog(s) have protein binding, bridging, protein transporter activity and role in proteasome localization, protein import into nucleus, protein targeting to membrane CAALFM_C500160WA Ortholog of C. dubliniensis CD36 : Cd36_50190, C. parapsilosis CDC317 : CPAR2_302680, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109949 and Debaryomyces hansenii CBS767 : DEHA2G00814g CAALFM_C500170WA Protein with predicted hydrolase domains; similar to a universal stress protein family protein; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm repressed CAALFM_C500180WA Ortholog(s) have inositol heptakisphosphate kinase activity, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 3-kinase activity, inositol hexakisphosphate 4-kinase activity, inositol hexakisphosphate 6-kinase activity CAALFM_C500190CA Beta subunit of fatty-acid synthase; multifunctional enzyme; Hap43, fluconazole-induced; amphotericin B, caspofungin repressed; macrophage/pseudohyphal-induced; flow model and Spider biofilm repressed CAALFM_C500200CA Bromodomain transcription factor; repressed upon adherence to polystyrene; reduced mRNA abundance detected in null mutant; macrophage/pseudohyphal-repressed; possibly essential, disruptants not obtained by UAU1 method CAALFM_C500210CA Putative transcription factor with C3HC4 zinc finger DNA-binding motif; similar to S. cerevisiae Bre1p; transposon mutation affects filamentous growth CAALFM_C500220WA Alpha-glucosidase II, catalytic subunit, required for N-linked protein glycosylation and normal cell wall synthesis; alkaline downregulated CAALFM_C500230CA Ortholog(s) have 5'-flap endonuclease activity, role in DNA-dependent DNA replication and Slx1-Slx4 complex localization CAALFM_C500240WA Putative homolog of S. cerevisiae Skn7p, which is predicted to be a response regulator protein in a phosphorelay signal transduction pathway; required for normal hydrogen peroxide resistance CAALFM_C500250CA Protein with a predicted role in microtubule-related processes; Spider biofilm induced CAALFM_C500260WA Ortholog(s) have ribose phosphate diphosphokinase activity and role in 5-phosphoribose 1-diphosphate biosynthetic process, cytokinesis, fungal-type cell wall organization CAALFM_C500270WA Putative GPI-anchored protein; induced during cell wall regeneration; regulated by Ssn6p CAALFM_C500280CA Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; Spider biofilm repressed CAALFM_C500290WA Ortholog(s) have tRNA dihydrouridine synthase activity, role in tRNA modification and mitochondrion localization CAALFM_C500300CA Ortholog(s) have ATPase activity, chromatin binding activity, role in DNA unwinding involved in DNA replication, mitotic chromosome condensation, rDNA condensation, tRNA gene clustering and cytosol, nuclear condensin complex localization CAALFM_C500310CA Protein with a fungal RNA polymerase I subunit RPA14 domain; proposed to play a role in the recruitment of pol I to the promoter; Hap43-induced gene CAALFM_C500320WA Ortholog(s) have mitochondrion, nucleus localization CAALFM_C500330CA Ortholog(s) have role in fermentation, protein maturation and mitochondrion localization CAALFM_C500340WA Protein of unknown function; Spider biofilm repressed CAALFM_C500350CA Putative DnaJ-like chaperone; Hap43-repressed gene CAALFM_C500370WA Putative cofilin; macrophage-induced protein; protein present in exponential and stationary-phase yeast cells, but higher amounts in stationary phase CAALFM_C500380WA Has domain(s) with predicted DNA binding activity CAALFM_C500390CA Protein of unknown function; transcript repressed upon yeast-hyphal switch; fluconazole-induced; Hap43-repressed; flow model biofilm induced CAALFM_C500400CA Ortholog of C. dubliniensis CD36 : Cd36_50420, C. parapsilosis CDC317 : CPAR2_304100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98299 and Debaryomyces hansenii CBS767 : DEHA2B07634g CAALFM_C500420CA Predicted mitochondrial ribosomal protein CAALFM_C500430WA Putative adenylylsulfate kinase; predicted role in sulfur metabolism; possibly adherence-induced; protein present in exponential and stationary growth phase yeast; F-12/CO2 biofilm induced CAALFM_C500440CA Ortholog(s) have role in intralumenal vesicle formation, protein retention in Golgi apparatus, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway CAALFM_C500450CA Putative D-amino acid oxidase; Spider biofilm induced CAALFM_C500460CA Putative multicopper ferro-O2-oxidoreductase; repressed in core caspofungin response; fails to complement S. cerevisiae fet3 iron-related phenotypes; rat catheter and Spider biofilm induced CAALFM_C500470CA Putative subunit of glucan synthase; macrophage-induced gene; Bcr1-regulated in a/a RPMI biofilms CAALFM_C500480CA Essential protein; functional homolog of S. cerevisiae Sec14p, a Golgi phosphatidylinositol/phosphatidylcholine transfer protein that regulates choline-phosphate cytidyltransferase and thereby affects secretion; biofilm-regulated CAALFM_C500490CA GTPase activating protein (GAP) for Rsr1; negative regulator of filament branching, acts in hyphal growth guidance; required for wild-type budding pattern; induced in low iron; regulated by tyrosol and cell density CAALFM_C500500WA Putative role in nonsense-mediated mRNA decay; similar to S. cerevisiae Nam7p; gene induced by ciclopirox olamine treatment CAALFM_C500510WA Ortholog of C. dubliniensis CD36 : Cd36_50520, C. parapsilosis CDC317 : CPAR2_304000, Candida tenuis NRRL Y-1498 : cten_CGOB_00233 and Debaryomyces hansenii CBS767 : DEHA2E12408g CAALFM_C500530WA Ortholog of C. dubliniensis CD36 : Cd36_50530, C. parapsilosis CDC317 : CPAR2_303990, Candida tenuis NRRL Y-1498 : CANTEDRAFT_107934 and Pichia stipitis Pignal : PICST_63283 CAALFM_C500540CA Protein with some similarity to agglutinin subunit; expression regulated upon white-opaque switch; Spider biofilm induced CAALFM_C500550CA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 and merged with orf19.2224, based on comparative genome analysis; flow model biofilm repressed CAALFM_C500560WA Ortholog(s) have ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity and role in UV-damage excision repair, free ubiquitin chain polymerization, postreplication repair, protein K63-linked ubiquitination CAALFM_C500570WA Putative aminophospholipid translocase (flippase); merged with orf19.2226 in Assembly 21; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C500580WA Ortholog of Candida albicans WO-1 : CAWG_04452 CAALFM_C500590WA Mitochondrial ADP/ATP carrier protein involved in ATP biosynthesis; possible lipid raft component; 3 predicted transmembrane helices; flucytosine induced; ketoconazole-induced; downregulated by Efg1p CAALFM_C500600CA Protein of unknown function; rat catheter biofilm repressed CAALFM_C500610CA Ortholog of C. dubliniensis CD36 : Cd36_50610, C. parapsilosis CDC317 : CPAR2_303690, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93989 and Debaryomyces hansenii CBS767 : DEHA2E15400g CAALFM_C500620WA Ortholog(s) have role in positive regulation of transcription from RNA polymerase II promoter, regulation of cell aging, telomere maintenance via recombination and EKC/KEOPS complex, cytosol, nucleus localization CAALFM_C500630CA Putative exodeoxyribonuclease; cell-cycle regulated periodic mRNA expression CAALFM_C500640CA Component of the SAM complex involved in mitochondrial protein import, involved in beta-barrel protein assembly; member of the Omp85 protein family CAALFM_C500650CA Putative homoserine kinase; regulated by Tup1; amphotericin B repressed; regulated by Gcn2 and Gcn4; Spider biofilm repressed CAALFM_C500660CA Lanosterol 14-alpha-demethylase; cytochrome P450 family; role in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole or flow model biofilm induced; drug treated biofilm induced; hypoxia regulated CAALFM_C500670CA hLh domain Myc-type transcript factor; required for morphogenesis induced by elevated temperature or Hsp90 compromise; acts downstream of Pcl1; Spider biofilm induced CAALFM_C500680WA Minor protein arginine methyltransferases (PRMT) involved in methylation of arginine residues CAALFM_C500690CA Putative C3HC4 zinc finger transcription factor; transcript positively regulated by Tbf1; Spider biofilm induced CAALFM_C500700CA Putative S-adenosylmethionine decarboxylase; Hap43-induced gene; possibly adherence-induced; Spider biofilm induced CAALFM_C500710WA Putative GPI-anchored adhesin-like protein; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 CAALFM_C500730WA Putative GPI-anchored adhesin-like protein; similar to Hyr1p induced in high iron; clade-specific repeat variation CAALFM_C500740WA Putative kinetochore protein with a predicted role in sister chromatid cohesion; repressed during the mating process; flow model biofilm induced CAALFM_C500750CA Predicted protein tyrosine phosphatase; rat catheter biofilm induced CAALFM_C500760WA Ortholog(s) have GTPase activator activity and role in activation of GTPase activity, endocytosis, exocytosis, formin-nucleated actin cable assembly, regulation of protein localization CAALFM_C500770CA Putative dihydroneopterin aldolase (dihydro-6-hydroxymethylpterin pyrophosphokinase); fungal-specific (no human or murine homolog) CAALFM_C500780CA Protein of unknown function; mutants are viable; Spider biofilm induced CAALFM_C500790CA Putative RNA-binding protein; transcript is upregulated in an RHE model of oral candidiasis CAALFM_C500800CA Indoleamine 2,3-dioxygenase (IDO); rate-limiting enzyme of tryptophan catabolism via kynurenine; enzyme inhibition by 1-methyl-D,L-tryptophan increases hyphal growth; expressed in yeast and hyphae; rat catheter and Spider biofilm induced CAALFM_C500810CA Has domain(s) with predicted heme binding, peroxidase activity and role in oxidation-reduction process, response to oxidative stress CAALFM_C500820WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C500830CA Putative ER-derived vesicle protein; COPII-coated vesicle complex subunit; transcript induced by filamentous growth; Spider biofilm repressed CAALFM_C500840WA Ortholog(s) have mRNA binding activity and transcription export complex localization CAALFM_C500850CA Ortholog(s) have role in aerobic respiration and mitochondrial intermembrane space, nucleus localization CAALFM_C500860WA Predicted subunit of the mitochondrial inner membrane peptidase complex involved in protein targeting to mitochondria CAALFM_C500870CA Glycerophosphocholine transporter; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene CAALFM_C500880CA Glycerophosphocholine permease; white cell specific transcript; fungal-specific; alkaline repressed; caspofungin, macrophage/pseudohyphal-repressed; flow model biofilm induced; Spider biofilm induced CAALFM_C500890CA Putative glycerophosphoinositol permease; fungal-specific; repressed by alpha pheromone in SpiderM medium; Hap43-repressed; Spider biofilm induced CAALFM_C500900CA Dihydroorotase; protein present in exponential and stationary growth phase yeast cultures CAALFM_C500910CA Similar to thioredoxins; not expected to be enzymatically active because it lacks a canonical thioredoxin active site (Trp-Cys-Gly-Pro-Cys); TRX1 encodes all of the cytoplasmic/nuclear thioredoxin function in C. albicans; Hap43p-induced CAALFM_C500920WA Ortholog(s) have role in mRNA splicing, via spliceosome, regulation of DNA methylation and U4/U6 x U5 tri-snRNP complex, U5 snRNP localization CAALFM_C500930CA Putative carboxypeptidase y inhibitor; transcript regulated upon yeast-hypha switch; colony morphology-related gene regulation by Ssn6 CAALFM_C500940CA Component of CCAAT-binding transcription factor; roles in filamentous growth, low-iron induction of FRP1; regulates genes involved in respiratory growth; functional homolog of S. cerevisiae Hap5p; Cap1p-dependent expression in low iron CAALFM_C500950CA Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in histone lysine methylation and cytoplasm, nuclear chromatin localization CAALFM_C500980WA RING-finger transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C501000CA Putative vacuole biogenesis protein CAALFM_C501010WA Putative mannoprotein of cell wall with role in response to stress; increased mRNA abundance observed in cyr1 homozygous mutant (hyphal or yeast-form cells) and in ras1 homozygous mutant (yeast-form cells) CAALFM_C501020CA Predicted non-catalytic subunit of N-terminal acetyltransferase; Spider biofilm induced CAALFM_C501040WA Ortholog of C. dubliniensis CD36 : Cd36_51280, C. parapsilosis CDC317 : CPAR2_501840, Candida tenuis NRRL Y-1498 : cten_CGOB_00020 and Debaryomyces hansenii CBS767 : DEHA2F24310g CAALFM_C501050CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C501060CA Putative methyltransferase; Hap43-induced; repressed by prostaglandins CAALFM_C501070CA Protein of unknown function; repressed by fluphenazine treatment; induced by benomyl treatment and in an RHE model; regulated by Nrg1, Tup1 CAALFM_C501080CA Putative mitochondrial protein; Hap43-repressed gene; Spider biofilm induced CAALFM_C501090CA Planktonic growth-induced gene CAALFM_C501100CA G1 cyclin; depletion abolishes budding and causes hyphal growth defects; farnesol regulated, functional in S. cerevisiae; possibly essential (UAU1 method); other biofilm induced; Spider biofilm induced CAALFM_C501110WA Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and cytosol, ribosome localization CAALFM_C501130WA Mitochondrial cytochrome c heme lyase; antigenic cell-wall protein; filament induced; induced on polystyrene adherence, interaction with macrophage; N-glycosylation, 2 heme-binding motifs; rat catheter, Spider biofilm induced CAALFM_C501140CA Ortholog(s) have mRNA binding activity, role in reciprocal meiotic recombination and mitochondrion localization CAALFM_C501170WA Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation, protein targeting to membrane and endoplasmic reticulum palmitoyltransferase complex, extrinsic component of endoplasmic reticulum membrane localization CAALFM_C501180WA Putative pseudouridine synthase; transcript regulated by Nrg1, Mig1, and Tup1 CAALFM_C501190WA Predicted protein of unknown function; merged with orf19.1952 in Assembly 21 CAALFM_C501200WA Ortholog(s) have ADP-ribosyl-[dinitrogen reductase] hydrolase activity, phosphatase activity CAALFM_C501210WA Dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p CAALFM_C501220WA Ortholog of C. dubliniensis CD36 : Cd36_51110, C. parapsilosis CDC317 : CPAR2_302560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135271 and Debaryomyces hansenii CBS767 : DEHA2E12914g CAALFM_C501230CA Similar to an aldose 1-epimerase-related protein; antigenic during murine systemic infection; protein present in exponential and stationary phase yeast cultures; Hap43-induced; Spider biofilm repressed CAALFM_C501240WA Inositolphosphorylceramide (IPC) synthase; catalyzes the key step in sphingolipid biosynthesis; antifungal drug target; flow model biofilm induced; Spider biofilm induced CAALFM_C501250WA Plasma membrane G-protein-coupled receptor of the cAMP-PKA pathway; required for WT hyphal growth; reports differ on role in cAMP-mediated glucose signaling; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1; flow model biofilm induced CAALFM_C501260WA Ortholog of C. parapsilosis CDC317 : CPAR2_302610, C. dubliniensis CD36 : Cd36_51070, Candida orthopsilosis Co 90-125 : CORT_0E04770 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_50634 CAALFM_C501270WA Putative multidrug resistance factor; induced in low iron; regulated by Sef1, Sfu1, and Hap43 CAALFM_C501280CA Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site CAALFM_C501290CA Ortholog(s) have 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity, role in ubiquinone biosynthetic process and mitochondrial inner membrane localization CAALFM_C501300CA Ortholog(s) have mRNA 3'-UTR binding activity, role in regulation of mRNA stability, regulation of phosphate metabolic process and cytoplasm localization CAALFM_C501310WA Ortholog of S.pombe SPCC825.05c; a predicted splicing coactivator; transcription repressed in azole-resistant strain overexpressing CDR1 and CDR2; induced by benomyl treatment CAALFM_C501320WA Essential protein; functional homolog of S. cerevisiae Snf1p regulator of sugar metabolism; constitutively expressed; Thr208 phosphorylation may have regulatory role; up-regulation associated with azole resistance; has polyhistidine tract CAALFM_C501340WA Histone H3K56 deacetylase; reduced copy number increases opaque cell formation; repressed by MMS, hydroxyurea and high-levels of hydrogen peroxide; Hap43p-induced; ectopic expression blocks genotoxin-induced switching; nicotinamide target CAALFM_C501350WA Ortholog(s) have role in peroxisome organization and peroxisomal membrane localization CAALFM_C501360WA C-terminus similar to ferric reductases; induced in low iron; Sfu1-repressed; ciclopirox olamine induced; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Sef1-regulated CAALFM_C501380WA Ferric reductase; induced in low iron; ciclopirox olamine, flucytosine induced; amphotericin B, Sfu1 repressed; Tbf1, Hap43 induced CAALFM_C501390CA Protein similar to RNase MRP RNA binding protein; ciclopirox olamine induced; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced CAALFM_C501400WA Zn(II)2Cys6 transcription factor, required for normal resistance to copper; repressed by Sfu1 in high-iron conditions; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced CAALFM_C501410CA Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization CAALFM_C501420WA Protein of unknown function; UPF0057 protein family member; localizes to the plasma membrane; Spider biofilm induced CAALFM_C501430CA Protein wth a predicted role in transcription from RNA polymerase II promoters; Spider biofilm induced CAALFM_C501440CA Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation and plasma membrane localization CAALFM_C501450WA Putative carboxypeptidase; induced by human neutrophils; Spider biofilm induced CAALFM_C501460WA Putative subunit of a replication fork-pausing checkpoint complex CAALFM_C501470CA Putative transporter; decreased transcription is observed upon fluphenazine treatment CAALFM_C501480WA Protein with a predicted role maturation of 18S rRNA; rat catheter biofilm induced CAALFM_C501490CA Predicted protein kinase; clade-associated gene expression CAALFM_C501500CA Zn(II)2Cys6 transcription factor orthologous to S. cerevisiae Hap1; regulated by Sef1, Sfu1; Hap43-induced; Spider biofilm induced CAALFM_C501510WA Putative core snRNP protein; induced upon adherence to polystyrene CAALFM_C501520CA Glutathione reductase; upregulated by human neutrophils; oxidative stress-induced regulation via Cap1p; overexpression correlates with multidrug resistance in a cap1 mutant, farnesol induced; stationary phase enriched protein CAALFM_C501530CA Has domain(s) with predicted anaphase-promoting complex localization CAALFM_C501540WA Protein component of the small (40S) ribosomal subunit; Spider biofilm repressed CAALFM_C501550CA Predicted protein of unknown function; overlaps orf19.4149.1 CAALFM_C501560CA Putative glutaredoxin; induced by nitric oxide; Spider biofilm induced CAALFM_C501570CA Protein similar to phospholipase B; fungal-specific (no human or murine homolog) CAALFM_C501580CA Translation elongation factor 3; antigenic in humans; predicted C-term nucleotide-binding active site; protein on surface of yeast, not hyphae; polystyrene adherence induced; higher protein amount in stationary phase; possibly essential CAALFM_C501590WA Ortholog(s) have NEDD8 activating enzyme activity, role in protein neddylation and cytosol, nucleus localization CAALFM_C501600CA Putative ATP-dependent RNA helicase; flucytosine repressed; Spider biofilm induced CAALFM_C501610WA Ortholog(s) have pseudouridine synthase activity, role in mRNA pseudouridine synthesis, tRNA pseudouridine synthesis and cytosol, nucleus localization CAALFM_C501620CA ESCRT-II complex protein with a role in multivesicular body (MVB) trafficking; required for processing of Rim8p; Hap43p-repressed gene CAALFM_C501640WA Putative processing peptidase, catalytic (alpha) subunit; protein level decreases in stationary phase cultures CAALFM_C501650CA Component of actomyosin ring at neck of newly-emerged bud CAALFM_C501670WA Putative allantoate permease; mutant is viable; similar but not orthologous to S. cerevisiae Dal5 CAALFM_C501680CA G1 cyclin; required for hyphal growth maintenance (not initiation); cell-cycle regulated transcription (G1/S); Cdc28p-Ccn1p initiates Cdc11p S394 phosphorylation on hyphal induction; expression in S. cerevisiae inhibits pheromone response CAALFM_C501690CA Cytosolic chaperonin Cct ring complex; protein is present in exponential and stationary growth phase yeast cultures; sumoylation target CAALFM_C501700WA Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced CAALFM_C501710CA Ortholog of C. dubliniensis CD36 : Cd36_51610, C. parapsilosis CDC317 : CPAR2_303630, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135125 and Debaryomyces hansenii CBS767 : DEHA2E19030g CAALFM_C501720CA Putative F-box protein involved in endocytic membrane traffic and/or recycling; fungal-specific (no human or murine homolog) CAALFM_C501730WA Ortholog of C. dubliniensis CD36 : Cd36_51590, C. parapsilosis CDC317 : CPAR2_303610, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135127 and Debaryomyces hansenii CBS767 : DEHA2E19074g CAALFM_C501740CA Homeodomain protein of the MTLa mating type locus; a1 and alpha2 together repress white-opaque switching and mating (an opaque-specific process); a/alpha mating type may increase virulence by competitive advantage; Spider biofilm induced CAALFM_C501750CA Master regulator (activator) of a-type mating; has HMG domain, which is predicted to bind DNA; gene has intron; not related to S. cerevisiae MATa2; a/alpha mating type may increase virulence, provides competitive advantage CAALFM_C501760CA Putative phosphatidylinositol kinase; non-sex gene located within the MTLa mating-type-like locus CAALFM_C501770CA Similar to oxysterol binding protein; non-sex gene located within the MTLa mating-type-like locus; Plc1p-regulated CAALFM_C501780WA Poly(A) polymerase, likely involved in mRNA polyadenylation; PAP is inhibited by parnafungin antifungals; non-sex gene located within the MTLa mating-type-like locus CAALFM_C501800CA Similar to amino acid permeases; alkaline, flucytosine induced; regulated by Plc1, Gcn2 and Gcn4; fungal-specific; Spider biofilm induced CAALFM_C501810WA bZIP transcription factor; ortholog of S. cerevisiae Yap3; partially complements fluconazole sensitivity of S. cerevisiae pdr1 pdr3; Hap43-induced; required for yeast cell adherence to silicone substrate; flow model biofilm repressed CAALFM_C501820WA Protein that interacts with Cdc37 and Crk1 in two-hybrid; may be involved in Cdc37 chaperone activity; soluble protein in hyphae; protein in exponential and stationary phase yeast cultures; YNB biofilm induced; Spider biofilm induced CAALFM_C501830CA Putative Zn(II)2Cys6 transcription factor; gene in zinc cluster region of Chr. 5; induced by Mnl1 in weak acid; similar to S. cerevisiae Hal9, a putative transcription factor involved in salt tolerance CAALFM_C501840CA Zn(2)-Cys(6) transcriptional activator of drug-responsive genes (CDR1 and CDR2); binds DRE element; gene in zinc cluster region near MTL locus; resequencing indicates that TAC1 spans orf19.3188 and orf19.3189; Spider biofilm induced CAALFM_C501850CA Zn(2)-Cys(6) transcription factor; regulated by Gcn2 and Gcn4; gene located in zinc cluster region of Chromosome 5, near the MTL locus; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C501870WA Ortholog(s) have peptide alpha-N-acetyltransferase activity, role in N-terminal protein amino acid acetylation and NatA complex, cytosolic ribosome, mitochondrion localization CAALFM_C501880CA Has domain(s) with predicted role in vesicle-mediated transport CAALFM_C501890WA Protein with a role in insertion of tail-anchored proteins into the ER membrane; required for efficient mating, in shmoo formation and nuclear migration in the pre-zygote of S. cerevisiae; Hap43-repressed CAALFM_C501900CA Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; Spider biofilm induced CAALFM_C501910WA Translational activator for mRNAs with internal ribosome entry sites; induced in high iron; repressed by yeast-hypha switch; null exhibits sensitivity to sorbitol, 5-fluorocytosine, and cold temperatures; Spider biofilm repressed CAALFM_C501920CA Ortholog(s) have phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, role in phosphatidylinositol dephosphorylation and endoplasmic reticulum localization CAALFM_C501930WA Ortholog(s) have RNA binding activity, role in mRNA 5'-splice site recognition and U2-type prespliceosome localization CAALFM_C501940WA Ortholog(s) have 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity, pseudouridine synthase activity, role in riboflavin biosynthetic process, tRNA pseudouridine synthesis and cytosol localization CAALFM_C501950CA Plasma membrane pH-sensor involved in the Rim101 pH response pathway; required for processing and activation of Rim101 and for alkaline pH-induced hyphal growth; Spider biofilm induced CAALFM_C501960CA Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); alkaline repressed; repressed by nitric oxide; virulence-group-correlated expression; Spider biofilm induced CAALFM_C501970CA GDP-GTP exchange factor for Cdc42p; phosphorylated; required for maintenance of hyphal growth; misexpression blocks hyphal growth and causes avirulence in a mouse model of systemic infection; antigenic during human oral infection CAALFM_C501980CA Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization CAALFM_C501990WA Ortholog of C. dubliniensis CD36 : Cd36_51840, Candida tropicalis MYA-3404 : CTRG_05315 and Candida albicans WO-1 : CAWG_04584 CAALFM_C502000CA Acetyl-coA hydrolase; acetate utilization; nonessential; soluble protein in hyphae; antigenic in human; induced on polystyrene adherence; farnesol-, ketoconazole-induced; no human or murine homolog; stationary phase-enriched protein CAALFM_C502010CA Ortholog(s) have role in RNA Polymerase I assembly, RNA Polymerase II core complex assembly, RNA Polymerase III assembly, formation of translation preinitiation complex and cytoplasm, cytosolic ribosome localization CAALFM_C502020CA Ortholog(s) have role in RNA polymerase II complex import to nucleus, RNA polymerase III complex localization to nucleus, establishment of mitotic sister chromatid cohesion and cytosol, nucleus localization CAALFM_C502030WA Putative regulatory subunit of the 26S proteasome; mutation confers hypersensitivity to amphotericin B; regulated by Mig1, Gcn2 and Gcn4; Spider biofilm repressed CAALFM_C502040WA Heme A:farnesyltransferase; catalyzes the 1st step in conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; Spider biofilm repressed CAALFM_C502050WA Ortholog(s) have role in Golgi to endosome transport, cell morphogenesis, endoplasmic reticulum organization and endosome, mitochondrion, trans-Golgi network localization CAALFM_C502060WA Ortholog of C. dubliniensis CD36 : Cd36_51910, C. parapsilosis CDC317 : CPAR2_101650, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94797 and Debaryomyces hansenii CBS767 : DEHA2D06578g CAALFM_C502070CA Ortholog(s) have ATPase activator activity, RNA binding activity CAALFM_C502080CA Heat-shock protein; induced by osmotic/oxidative/cadmium stress, fluphenazine treatment, low iron, CDR1 and CDR2 overexpression, or ssn6 or ssk1 null mutation; overexpression increases resistance to farnesol and azoles CAALFM_C502110WA Putative heat shock protein; decreased expression in hyphae; transcription is increased in populations of cells exposed to fluconazole over multiple generations; overexpression increases resistance to farnesol and azoles CAALFM_C502120CA Putative ATPase of the AAA family; role in ribosomal subunit export from the nucleus; mutation impairs hyphal growth and biofilm formation CAALFM_C502130WA Ortholog of Candida tropicalis MYA-3404 : CTRG_03197, Candida lusitaniae ATCC 42720 : CLUG_02837 and Candida albicans WO-1 : CAWG_04597 CAALFM_C502140CA Predicted pyridoxal 5'-phosphate synthase; regulated by Gcn4; repressed by amino acid starvation (3-AT treatment); rat catheter biofilm repressed CAALFM_C502150CA Phosphorylated protein similar to S. cerevisiae Orc4, subunit of the origin recognition complex (ORC); induced by alpha pheromone in SpiderM medium CAALFM_C502160WA Predicted regulator of G-protein signaling in mating pathway; null mutation causes alpha-factor hypersensitivity and mating defect (in opaque MTLa/MTLa background); transcript induced by alpha factor CAALFM_C502170CA Gamma subunit of translation initiation factor eIF2; involved in identification of the start codon; likely essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed CAALFM_C502180CA Zn(II)2Cys6 transcription factor; predicted regulator branched-c ofhain amino acid biosynthesis genes; alkaline induced; induced by Mnl1 under weak acid stress; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C502190CA Ortholog(s) have oxoglutarate dehydrogenase (succinyl-transferring) activity, structural constituent of ribosome activity and role in 2-oxoglutarate metabolic process, tricarboxylic acid cycle CAALFM_C502200WA Ortholog of C. parapsilosis CDC317 : CPAR2_100400, C. dubliniensis CD36 : Cd36_52020, Debaryomyces hansenii CBS767 : DEHA2F14278g and Candida orthopsilosis Co 90-125 : CORT_0F00500 CAALFM_C502210WA Protein with a role in insertion of tail-anchored proteins into the ER membrane; Spider biofilm repressed CAALFM_C502220CA Putative polyphosphate phosphatase; role in hydrolysis of diphosphorylated inositol polyphosphates and diadenosine polyphosphates; Spider biofilm induced CAALFM_C502230WA 20S proteasome subunit (beta7); protein present in exponential and stationary growth phase yeast cultures CAALFM_C502240WA Putative cAMP-independent regulatory protein; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced CAALFM_C502260CA Putative gluconate transport protein; antigenic during human oral infection; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C502270WA Putative threonine synthase; protein present in exponential and stationary growth phase yeast cultures; Gcn4p-regulated; sumoylation target CAALFM_C502280CA Protein of unknown function; Hap43-induced gene; Ctr86 ortholog in S. cerveisiae is essential; Spider biofilm induced CAALFM_C502290WA Low affinity cyclic nucleotide phosphodiesterase; mediates cAMP signaling in response to glucose or intracellular acidification; macrophage-repressed; Spider biofilm induced CAALFM_C502300CA Delta subunit of the coatomer complex (COPI); coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; interacts with Crk1 in the two-hybrid system; Spider biofilm repressed CAALFM_C502310CA Planktonic growth-induced gene CAALFM_C502320CA Ortholog(s) have role in GPI anchor biosynthetic process, cellular manganese ion homeostasis and endoplasmic reticulum, fungal-type vacuole membrane localization CAALFM_C502330WA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C502340CA Protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates some hyphal growth; involved in Cdc42p growth regulation CAALFM_C502350CA Ortholog(s) have ubiquitin binding activity CAALFM_C502360CA Ortholog of Candida albicans WO-1 : CAWG_04619 CAALFM_C502370CA Protein with a predicted pleckstrin domain; Hap43-repressed gene CAALFM_C502380WA Protein with similarity to S. cerevisiae Ykr070w; Tn mutation affects filamentation; Hog1-repressed; colony morphology-related gene regulation by Ssn6p; induced during cell wall regeneration; possibly essential CAALFM_C502390CA Protein of unknown function; rat catheter and Spider biofilm repressed CAALFM_C502400WA Ortholog of S. cerevisiae YLR118C (alias Apt1); acyl-protein thioesterase responsible for depalmitoylation of Gpa1 in S. cerevisiae; regulated by Gcn4; repressed in response to amino acid starvation (3AT); rat catheter biofilm repressed CAALFM_C502410CA Ortholog of C. dubliniensis CD36 : Cd36_52200, C. parapsilosis CDC317 : CPAR2_502480, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115972 and Debaryomyces hansenii CBS767 : DEHA2G19976g CAALFM_C502430WA Predicted Zn(II)2Cys6 transcription factor CAALFM_C502440CA Ortholog(s) have protein serine/threonine kinase activity CAALFM_C502450WA Ortholog(s) have role in negative regulation of gluconeogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of nitrogen utilization and GID complex, cytoplasm, nucleus localization CAALFM_C502460CA GPI-anchored protein; mainly at plasma membrane, also at cell wall; Hap43, caspofungin-induced; Plc1-regulated; Hog1, Rim101-repressed; colony morphology-related regulated by Ssn6; induced by ketoconazole and hypoxia CAALFM_C502470WA Protein structurally similar to alpha-subunit of human leukocyte integrin; role in morphogenesis, adhesion, and mouse cecal colonization and systemic virulence; similar to S. cerevisiae Bud4; Hap43-induced gene CAALFM_C502480WA Puttaive pre-mRNA polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C502490CA Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_C502500CA Ortholog(s) have mRNA binding activity and role in cellular protein complex localization, establishment of mitochondrion localization, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay CAALFM_C502510CA Has domain(s) with predicted nucleotide binding activity CAALFM_C502520WA Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; flow model biofilm induced CAALFM_C502530WA UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated CAALFM_C502540CA Septin; similar to S. cerevisiae meiotic/sporulation septin; mutant has no obvious phenotype; two introns with noncanonical branch site and 5' splice site, respectively; splicing inhibited upon exposure to alpha-factor CAALFM_C502550CA Putative U3 snoRNA-associated protein; Hap43-induced; repressed in core stress response; physically interacts with TAP-tagged Nop1 CAALFM_C502560CA Has domain(s) with predicted ATP binding, protein kinase activity and role in protein phosphorylation CAALFM_C502570WA Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C502580WA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C502590CA Putative mitochondrial membrane protein; ortholog of S. cerevisiae Sls1; coordinates expression of mitochondrially-encoded genes; Hap43-induced CAALFM_C502600WA Putative proline oxidase; alkaline upregulated by Rim101; flow model biofilm induced; Spider biofilm induced CAALFM_C502610CA DNA damage-dependent checkpoint protein; involved in regulation of DNA-damage-induced filamentous growth; induced by alpha pheromone in SpiderM medium CAALFM_C502620CA Ortholog(s) have chromatin binding, methylated histone binding activity and role in negative regulation of transcription from RNA polymerase II promoter CAALFM_C502630CA Putative alpha-1,3-mannosyltransferase; of the mannosyltransferase complex; negatively regulated by Rim101; transcript elevated in chk1 and nik1 mutants, but not in sln1 mutant; Spider and flow model biofilm induced CAALFM_C502640WA Protein of unknown function; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C502650CA Transcription factor; forms a heterodimer with Fhl11 that is tethered to promoters by Tbf1; positively regulates rRNA and ribosomal protein gene transcription; Spider biofilm induced CAALFM_C502660CA Ortholog(s) have role in cytoplasmic translational initiation CAALFM_C502670WA Protein with similarity to S. cerevisiae Bur2p, contains a cyclin domain; not required for wild-type hyphal growth, adherence to buccal epithelial cells, or virulence in mouse systemic infection CAALFM_C502680WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C502690WA Putative oxidoreductase; Hap43-repressed gene; clade-associated gene expression CAALFM_C502700WA Zn(II)2Cys6 transcription factor; activates transcription in 1-hybrid assay in S. cerevisiae; has similarity to S. cerevisiae Stb4 CAALFM_C502710WA Thioredoxin reductase; regulated by Tsa1/Tsa1B, Hap43; induced by nitric oxide, peroxide; oxidative stress-induce via Cap1; induced by human neutrophils; stationary phase enriched protein CAALFM_C502720WA Predicted target membrane receptor (t-SNARE) involved in vacuolar transport, endocytosis, and secretion; required for biofilm formation in RPMI-1640 and for virulence CAALFM_C502730CA Ortholog(s) have role in iron-sulfur cluster assembly, tRNA wobble uridine modification and cytosol, nucleus localization CAALFM_C502740WA Ortholog(s) have oxidoreductase activity, role in cytochrome c-heme linkage, mitochondrial membrane organization and extrinsic component of mitochondrial inner membrane localization CAALFM_C502750CA Ortholog(s) have DNA binding, nucleosome binding, transcription corepressor activity CAALFM_C502760WA Regulatory subunit of protein kinase CK2 (casein kinase II), beta' subunit; null mutants are hypersensitive to caspofungin CAALFM_C502770WA Protein similar to S. cerevisiae Msw1p, which is mitochondrial tryptophanyl-tRNA synthetase; Hap43p-repressed gene; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C502780WA Ortholog(s) have role in chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, regulation of transcription from RNA polymerase II promoter and nucleus localization CAALFM_C502790CA Amino acid permease; antigenic in human/mouse; 10-12 transmembrane regions; regulated by nitrogen source; alkaline, GlcNAc, phagocytosis induced; WT virulence in mice; Spider and flow model biofilm induced CAALFM_C502800CA Ortholog of C. dubliniensis CD36 : Cd36_52590, C. parapsilosis CDC317 : CPAR2_100565, Debaryomyces hansenii CBS767 : DEHA2G06908g and Candida guilliermondii ATCC 6260 : PGUG_02858 CAALFM_C502810WA Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U4/U6 x U5 tri-snRNP complex, U6 snRNP, nucleolus localization CAALFM_C502820CA Ortholog(s) have methylthioribulose 1-phosphate dehydratase activity, role in L-methionine biosynthetic process from methylthioadenosine and cytosol, nucleus localization CAALFM_C502830WA Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole and late endosome localization CAALFM_C502840CA Probable protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of Swe1p and Cdc28p; required for full virulence and kidney colonization in mouse systemic infection CAALFM_C502860CA Methylglyoxal reductase; regulation associated with azole resistance; induced in core stress response or by oxidative stress via Cap1, fluphenazine, benomyl, by Hap43 or with long term fluconazole treatment; Spider biofilm induced CAALFM_C502890WA Nucleoside diphosphate kinase (NDP kinase); homo-hexameric; soluble protein in hyphae; flucytosine induced; biofilm induced; macrophage-induced protein; stationary phase enriched protein; Spider biofilm repressed CAALFM_C502900WA Ortholog(s) have TBP-class protein binding, transcription cofactor activity CAALFM_C502910CA Ortholog(s) have GTPase activator activity, role in vesicle-mediated transport and intracellular localization CAALFM_C502920WA Trimethyllysine dioxygenase, the first enzyme in the carnitine biosynthesis pathway; hypha-induced expression, regulated by Cyr1, Ras1, Efg1; rat catheter biofilm repressed CAALFM_C502930CA Putative D-xylose reductase; antigenic in murine systemic infection; soluble protein in hyphae; induced by farnesol, macrophage interaction and by Mnl1 under weak acid stress; stationary-phase enriched protein; Spider biofilm induced CAALFM_C502940CA C2H2 transcription factor; repressor; regulates genes for carbon source utilization; Tup1-dependent and independent functions; hyphal, Hap43 and caspofungin repressed; Spider and flow model biofilm induced CAALFM_C502970WA Putative dipeptidyl aminopeptidase; transcriptionally regulated during macrophage response CAALFM_C502980CA Ortholog(s) have phosphatidylinositol-3-phosphate binding activity and endosome localization CAALFM_C502990WA Has domain(s) with predicted NADH dehydrogenase (ubiquinone) activity, electron carrier activity and membrane localization CAALFM_C503000CA Ortholog of C. dubliniensis CD36 : Cd36_52760, C. parapsilosis CDC317 : CPAR2_303150, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133407 and Debaryomyces hansenii CBS767 : DEHA2G08030g CAALFM_C503010WA Ortholog(s) have role in mRNA splicing, via spliceosome, maturation of 5S rRNA and U4/U6 x U5 tri-snRNP complex localization CAALFM_C503020WA Copper-transporting P-type ATPase of Golgi; required for wild-type iron assimilation (indirect effect via Fet3p); induced by iron starvation, ciclopirox olamine; caspofungin repressed; not required for virulence in mouse systemic infection CAALFM_C503030WA Ortholog of C. dubliniensis CD36 : Cd36_52790, Candida tropicalis MYA-3404 : CTRG_05968 and Candida albicans WO-1 : CAWG_04684 CAALFM_C503040WA Ortholog of C. dubliniensis CD36 : Cd36_52800, C. parapsilosis CDC317 : CPAR2_303110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92321 and Debaryomyces hansenii CBS767 : DEHA2G07964g CAALFM_C503050CA Putative GPI-anchored protein; transcription is positively regulated by Tbf1p CAALFM_C503060CA Putative nicotinic acid transporter; detected at germ tube plasma membrane by mass spectrometry; transcript induced upon phagocytosis by macrophage; rat catheter biofilm induced CAALFM_C503070WA Ribosomal protein S5; macrophage/pseudohyphal-induced after 16 h; downregulated upon phagocytosis by murine macrophage; Hap43-induced; Spider biofilm repressed CAALFM_C503080CA Predicted membrane transporter; monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); Spider biofilm induced; rat catheter biofilm repressed CAALFM_C503090WA AAA-ATPase involved in transport from MVB to the vacuole and ESCRT-III complex disassembly; mutation decreases SAP secretion and virulence in murine intravenous infection; regulated by Gcn2p, Gcn4p; required for normal Rim8p processing CAALFM_C503100CA Ortholog of C. dubliniensis CD36 : Cd36_52890, C. parapsilosis CDC317 : CPAR2_501970, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113546 and Debaryomyces hansenii CBS767 : DEHA2E09900g CAALFM_C503110CA Ortholog(s) have role in mRNA splicing, via spliceosome and U1 snRNP, U2 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol, spliceosomal complex localization CAALFM_C503120WA Ortholog(s) have role in attachment of GPI anchor to protein and GPI-anchor transamidase complex localization CAALFM_C503130WA Zn2Cys6 transcription factor involved in sterol uptake; flow model biofilm induced; Spider biofilm repressed CAALFM_C503140CA Ortholog(s) have protein anchor activity, role in COPII vesicle coating, macroautophagy, protein localization to endoplasmic reticulum exit site and ER to Golgi transport vesicle membrane, endoplasmic reticulum exit site localization CAALFM_C503150WA Putative serine/threonine protein kinase; Hog1p-induced CAALFM_C503160WA RNA polymerase II mediator complex subunit CAALFM_C503170CA Protein of unknown function; transcript repressed by elevated CO2; Spider biofilm induced CAALFM_C503210CA Protein of unknown function CAALFM_C503240WA Protein similar to S. cerevisiae Bub3; a kinetochore checkpoint component; induced by hydroxyurea treatment; flow model biofilm induced; Spider biofilm induced CAALFM_C503250WA Putative lysine methyltransferase; Hap43-induced; protein induced during mating; possibly essential, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced CAALFM_C503260CA Protein with a transient receptor potential (TRP) ion channel domain; mutants are viable; rat catheter and Spider biofilm induced; flow model biofilm repressed CAALFM_C503270WA Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C503280WA Putative translation elongation factor; downregulated upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed CAALFM_C503290CA Mitochondrial ribosomal protein of the small subunit; Spider biofilm repressed CAALFM_C503300CA Protein of unknown function; rat catheter biofilm induced CAALFM_C503310CA Cyclin homolog; transcript induced by filamentous growth; induced by alpha pheromone in SpiderM medium CAALFM_C503320CA Putative Zn(II)2Cys6 transcription factor; caspofungin induced CAALFM_C503330CA Predicted Zn(II)2Cys6 transcription factor; similar to but not the true ortholog of S. cerevisiae Hap1; mutants display decreased colonization of mouse kidneys CAALFM_C503350WA Ubiquinol-cytochrome-c reductase; antigenic; induced by interaction with macrophage; repressed by nitric oxide; in detergent-resistant membrane fraction (possible lipid raft component); levels decrease in stationary phase; Hap43p-repressed CAALFM_C503360WA Putative RNA polymerase subunit; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test CAALFM_C503370CA Ortholog(s) have myosin II binding activity, role in actomyosin contractile ring contraction and cellular bud neck contractile ring, myosin II complex localization CAALFM_C503380WA Putative centractin; induced upon adherence to polystyrene CAALFM_C503390CA Uracil phosphoribosyltransferase; predicted tetrameric enzyme of pyrimidine salvage; mutations associated with flucytosine resistance in clade I clinical isolates; flucytosine, macrophage-induced protein; levels decrease in stationary phase CAALFM_C503400CA Lsm (Like Sm) protein; predicted role in involved in mRNA decay; Spider biofilm repressed CAALFM_C503410CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C503430WA Protein of unknown function; Spider biofilm induced CAALFM_C503440WA Protein of unknown function CAALFM_C503460CA Ortholog(s) have Golgi apparatus, fungal-type vacuole membrane localization CAALFM_C503470CA Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS) CAALFM_C503480CA Spermidine transporter; induced in strains from HIV patients with oral candidiasis; alkaline repressed; amphotericin B induced; colony morphology regulated by Ssn6; reduced oral epithelial cell damage by mutant; Spider biofilm induced CAALFM_C503490CA Stationary phase enriched protein; predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C503500WA Broad-specificity amino acid permease; Plc1, Gcn4 regulated; rat catheter biofilm induced CAALFM_C503510CA Protein of unknown function; mRNA binds to She3; Hap43-repressed; rat catheter and flow model biofilm induced CAALFM_C503520WA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C503530CA Putative coenzyme Q (ubiquinone) binding protein; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis CAALFM_C503540CA Ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; 5'-UTR intron; Hap43-induced; Spider biofilm repressed CAALFM_C503550WA Ortholog(s) have Ran GTPase binding, nucleocytoplasmic transporter activity CAALFM_C503560WA Predicted histone deacetylase activity; Spider biofilm induced CAALFM_C503570WA Ortholog(s) have ubiquitin binding, ubiquitin-protein transferase activator activity and role in ER-associated ubiquitin-dependent protein catabolic process, establishment of protein localization to endoplasmic reticulum membrane CAALFM_C503580CA Component of the chromatin assembly factor I (CAF-1); involved in regulation of white-opaque switching frequency; macrophage-induced CAALFM_C503590WA Protein similar to aminopeptidase I; mutation confers hypersensitivity to amphotericin B; transcript regulated in macrophage response; flow model biofilm induced CAALFM_C503600WA Putative member of the HSP40 (DnaJ) family of chaperones; rat catheter and Spider biofilm induced CAALFM_C503610WA Beta-N-acetylhexosaminidase/chitobiase, highly glycosylated enzyme that is secreted to the periplasm and culture medium; required for full virulence; may have role in carbon or nitrogen scavenging; possibly an essential gene (UAU1 method) CAALFM_C503620WA Putative geranylgeranyl diphosphate synthase; repressed by benomyl treatment; Spider biofilm induced CAALFM_C503630CA Protein of unknown function; from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis; F-12/CO2 early biofilm induced CAALFM_C503640WA Ortholog(s) have cytosol, nucleus localization CAALFM_C503650CA Protein of unknown function; Hap43-repressed gene CAALFM_C503670CA Ortholog(s) have cytosol, nucleus localization CAALFM_C503680WA Zn(II)2Cys6 transcription factor; transposon mutation affects filamentous growth; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_C503690WA Protein of unknown function; Spider biofilm induced CAALFM_C503700CA Ortholog(s) have diphthine synthase activity, role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytosol, nucleus localization CAALFM_C503710CA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C503730WA Protein of unknown function; induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C503740WA Ortholog of C. dubliniensis CD36 : Cd36_53470, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93324, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_55715 and Candida tropicalis MYA-3404 : CTRG_05538 CAALFM_C503750WA Adhesin-like protein; induced by mating factor in MTLa/a opaque cells, in cyr1 null, in filaments; regulated by Nrg1, Rfg1, Tup1, Tec1, Efg1, Ntd80, Rob1, Brg1; induced in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C503760CA Putative importin; member of a family of fungal-specific nuclear importins; Mig1-regulated CAALFM_C503770CA Protein similar to Candida boidinii formate dehydrogenase; virulence-group-correlated expression; Hap43-repressed; Spider biofilm repressed CAALFM_C503780CA Protein of unknown function; planktonic growth-induced gene CAALFM_C503790WA Putative guanylate kinase; identified in extracts from biofilm and planktonic cells; protein level decrease in stationary phase cultures; Hap43p-induced gene CAALFM_C503800WA Cytochrome c oxidase subunit; membrane-localized protein; rat catheter biofilm induced CAALFM_C503810CA Ortholog of C. dubliniensis CD36 : Cd36_53540, Debaryomyces hansenii CBS767 : DEHA2G07854g, Pichia stipitis Pignal : PICST_32162 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_50795 CAALFM_C503820CA Ortholog(s) have role in Golgi to plasma membrane transport, fungal-type cell wall chitin biosynthetic process and cell division site, clathrin-coated vesicle, cytosol, exomer complex, nucleus, ribosome localization CAALFM_C503830CA Ortholog(s) have chromatin binding, protein complex scaffold activity and role in RNA polymerase II transcriptional preinitiation complex assembly, histone acetylation CAALFM_C503840WA Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); active as a homodimer CAALFM_C503850WA Ortholog of C. dubliniensis CD36 : Cd36_53580, C. parapsilosis CDC317 : CPAR2_303030, Debaryomyces hansenii CBS767 : DEHA2G07766g and Pichia stipitis Pignal : psti_CGOB_00176 CAALFM_C503860WA Putative deoxyribonucleoside triphosphate pyrophosphohydrolase; caspofungin repressed; regulated by Gcn2p and Gcn4p CAALFM_C503870CA Protein of unknown function; Spider biofilm induced CAALFM_C503880CA Protein with Mob2p-dependent hyphal regulation; fluconazole-induced CAALFM_C503890CA Protein of unknown function CAALFM_C503900WA Regulator of sorbose utilization; putative GPI-anchor; hypha and cell wall regeneration induced; colony morphology-related gene regulation by Ssn6; induced by Tbf1, Hap43; Spider biofilm induced CAALFM_C503910CA Ortholog of C. parapsilosis CDC317 : CPAR2_302980, C. dubliniensis CD36 : Cd36_53630, Pichia stipitis Pignal : PICST_32155 and Candida orthopsilosis Co 90-125 : CORT_0E05120 CAALFM_C503920CA Putative rRNA processing protein; Spider biofilm induced CAALFM_C503930CA Ortholog of S. cerevisiae Sia1; involved in activation of the Pma1 plasma membrane H+-ATPase by glucose in S. cerevisiae; Spider biofilm induced CAALFM_C503940CA Putative multidrug resistance protein; upregulated by Efg1p CAALFM_C503950WA Similar to Rab GTPase activators; Hap43p-induced gene CAALFM_C503960WA Putative plasma membrane protein; in S. cerevisiae it is localized to the cell bud and mating projection membrane; repressed by alpha pheromone in SpiderM medium CAALFM_C503970WA Alpha/beta-HydrolasE superfamily protein; membrane-localized CAALFM_C503980WA Protein of unknown function; Spider biofilm induced CAALFM_C503990WA Putative stretch-activated Ca2+ channel of the high affinity calcium uptake system; role in thigmotropism; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain with CDR1 and CDR2 overexpression CAALFM_C504000WA Putative heteropentameric replication factor C subunit; transcription is induced upon filamentous growth CAALFM_C504010CA Predicted protein of unknown function; Plc1-regulated CAALFM_C504020CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C504030WA Protein of unknown function; flow model biofilm induced; Spider biofilm induced CAALFM_C504050WA Plasma membrane-localized protein of unknown function; Hap43p-repressed gene CAALFM_C504060CA Cell cycle checkpoint protein with a role in genome integrity; RNA abundance regulated by tyrosol and cell density CAALFM_C504070CA Ortholog(s) have cyclin-dependent protein serine/threonine kinase activator activity, histone binding, protein complex binding, ubiquitin binding, zinc ion binding activity CAALFM_C504080CA Putative splicing factor required for the first step of pre-mRNA splicing; Spider biofilm induced CAALFM_C504090CA Putative translation initiation factor; flucytosine induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C504100WA Protein similar to S. cerevisiae Cds1p; transposon mutation affects filamentous growth CAALFM_C504110WA Cell wall protein; repressed in ace2 mutant; repressed in core caspofungin response; induced in high iron; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm repressed CAALFM_C504120CA Putative inositol oxygenase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced CAALFM_C504130CA GPI-linked chitinase; required for normal filamentous growth; repressed in core caspofungin response; fluconazole, Cyr1, Efg1, pH-regulated; mRNA binds She3 and is localized to yeast-form buds and hyphal tips; Spider biofilm repressed CAALFM_C504140WA Protein of unknown function; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; transcription is repressed in response to alpha pheromone in SpiderM medium CAALFM_C504150CA Ortholog(s) have SNAP receptor activity, role in endocytosis, vesicle fusion and SNARE complex, endoplasmic reticulum, endosome, trans-Golgi network localization CAALFM_C504160WA Putative COMPASS/SET1C histone methyltransferase complex subunit CAALFM_C504170WA Ortholog(s) have role in mitochondrial fusion and integral component of mitochondrial outer membrane localization CAALFM_C504180WA Putative benzene desulfurase; induced by nitric oxide independent of Yhb1p CAALFM_C504190WA Protein of unknown function; repressed by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; Spider biofilm induced CAALFM_C504200WA Ortholog of Candida albicans WO-1 : CAWG_04793 CAALFM_C504210CA Protein of unknown function; Spider biofilm induced CAALFM_C504220WA Planktonic growth-induced gene CAALFM_C504230WA Ortholog of Candida albicans WO-1 : CAWG_04796 CAALFM_C504250WA Protein of unknown function; Spider biofilm induced CAALFM_C504260WA Has domain(s) with predicted RNA binding, ribonuclease T2 activity CAALFM_C504270CA S-adenosyl-L-homocysteine hydrolase; sulfur amino acid metabolism; antigenic in human; alkaline-, fluconazole-induced expression; Gcn4-regulated; amino acid starvation (3-AT) repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C504280CA GATA transcription factor, involved in regulation of nitrogen starvation-induced filamentous growth; regulates transcription of Mep2 ammonium permease; regulated by Gcn2 and Gcn4; mRNA binds She3; Spider biofilm induced CAALFM_C504290CA Has domain(s) with predicted translation initiation factor activity, role in translational initiation and cytoplasm localization CAALFM_C504300CA Putative metallodipeptidase; protein present in exponential and stationary growth phase yeast; Hog1-induced; Hap43-repressed; sumoylation target; Spider biofilm repressed CAALFM_C504310WA Ortholog of C. dubliniensis CD36 : Cd36_53980, C. parapsilosis CDC317 : CPAR2_100980, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116966 and Debaryomyces hansenii CBS767 : DEHA2G19822g CAALFM_C504320CA RNI-like superfamily domain-containing protein; early-stage flow model biofilm induced; Spider biofilm induced CAALFM_C504330WA Putative adhesin-like protein CAALFM_C504340WA Ortholog(s) have protein disulfide isomerase activity, protein disulfide oxidoreductase activity, protein-disulfide reductase (glutathione) activity, role in protein folding and fungal-type vacuole localization CAALFM_C504350CA Ortholog(s) have cell division site, cell tip, cytosol, nucleus localization CAALFM_C504360CA Possible pyrimidine 5' nucleotidase; protein present in exponential and stationary growth phase yeast cultures; Hap43p-repressed gene CAALFM_C504370CA Putative GPI-anchored protein; Hap43-repressed; Spider biofilm induced CAALFM_C504380CA Ortholog of Candida albicans WO-1 : CAWG_04810 CAALFM_C504390CA Putative protein of unknown function, transcription is activated in the presence of elevated CO2 CAALFM_C504400WA Ortholog(s) have endoribonuclease activity, role in RNA catabolic process, apoptotic process, cell morphogenesis and cytosol, extracellular region, fungal-type vacuole localization CAALFM_C504410CA Putative transcription factor with zinc finger DNA-binding motif CAALFM_C504420WA Ortholog(s) have mitochondrion localization CAALFM_C504430CA Putative ubiquitin C-terminal hydrolase; sumoylation target CAALFM_C504440CA Putative succinate-fumarate transporter; involved in repression of growth on sorbose; alkaline induced; rat catheter biofilm induced; Spider biofilm induced CAALFM_C504460CA Protein of unknown function CAALFM_C504470CA Predicted RNA binding protein; stationary phase enriched; induced in core caspofungin response; induced by nitric oxide independent of Yhb1; repressed in ssr1 null; ketoconazole, hypoxia induced; Spider biofilm induced CAALFM_C504480CA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_C504490CA Arginase; arginine catabolism; transcript regulated by Nrg1, Mig1, Tup1; colony morphology-related regulation by Ssn6; alkaline induced; protein decreased in stationary phase; sumoylation target; flow model biofilm induced CAALFM_C504510WA Glycerophosphocholine phosphodiesterase; mutation confers hypersensitivity to 5-fluorouracil (5-FU); F-12/CO2 early biofilm induced CAALFM_C504520WA Protein involved in TOR signaling pathway; regulates protein phosphatase 2A (PP2A) activity; regulates Rad53p during recovery from DNA damage CAALFM_C504530WA Putative mitochondrial ribosomal protein of the small subunit; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) CAALFM_C504540CA Ortholog of C. dubliniensis CD36 : Cd36_54170, C. parapsilosis CDC317 : CPAR2_100960, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96367 and Debaryomyces hansenii CBS767 : DEHA2G24618g CAALFM_C504550WA Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex, cell division site, cytosol, mitotic spindle pole body, nucleus localization CAALFM_C504560CA Metallothionein; involved in copper resistance; copper induced; Spider biofilm induced; flow model biofilm repressed CAALFM_C504570CA CTP synthase 1; flucytosine induced; protein present in exponential and stationary growth phase yeast cultures CAALFM_C504580CA Ortholog(s) have structural molecule activity CAALFM_C504590CA Putative ribosomal protein, large subunit; repressed by human whole blood or PMNs; colony morphology-related gene regulation by Ssn6; Spider biofilm repressed CAALFM_C504600CA F-box protein component of the SCF ubiquitin-ligase complex required for cell cycle progression; involved in negative control of pseudohyphal growth; Spider biofilm induced CAALFM_C504610WA Predicted COP9 signalosome complex subunit 12; flow model biofilm induced CAALFM_C504620CA Ortholog(s) have membrane insertase activity, role in protein insertion into mitochondrial membrane from inner side, respiratory chain complex IV assembly and integral component of mitochondrial inner membrane localization CAALFM_C504630WA Ortholog(s) have rDNA binding activity CAALFM_C504640CA Ortholog(s) have chromatin binding, histone binding activity CAALFM_C504650CA Mitochondrial methionyl-tRNA synthetase (MetRS); functionally complements methionine auxotrophy of an E. coli MetRS mutant; transcript regulated by Nrg1; flow model biofilm induced CAALFM_C504660CA Protein with a predicted role in biogenesis of ER-derived COPII transport vesicles; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_C504670WA Signal recognition particle (SRP) receptor alpha subunit; involved in SRP-dependent protein targeting; rat catheter biofilm repressed CAALFM_C504680WA Ortholog(s) have phosphatidylserine decarboxylase activity, role in phosphatidylcholine biosynthetic process and cell division site, cytosol, endosome localization CAALFM_C504690CA Ortholog of C. parapsilosis CDC317 : CPAR2_101170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113855, Debaryomyces hansenii CBS767 : DEHA2G20240g and Pichia stipitis Pignal : psti_CGOB_00174 CAALFM_C504700CA Cytoplasmic methionyl-tRNA synthetase; zinc-binding motif; ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary phase yeast CAALFM_C504710WA Ortholog(s) have glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity and role in endoplasmic reticulum organization, glutaminyl-tRNAGln biosynthesis via transamidation CAALFM_C504720CA Ortholog(s) have GTP cyclohydrolase I activity, role in folic acid-containing compound biosynthetic process and cytosol, nucleus localization CAALFM_C504730CA Protein with role in resistance to host antimicrobial peptides; virulence role in murine infection; functional homolog of S. cerevisiae Ssd1p, which suppresses various mutant phenotypes; constitutively expressed and not cell-cycle regulated CAALFM_C504740CA Putative DNA polymerase III (delta) subunit with a predicted role in DNA replication and DNA repair; cell-cycle regulated periodic mRNA expression CAALFM_C504750CA Functional homolog of S. cerevisiae Has1p, which is a nucleolar protein of the DEAD-box ATP-dependent RNA helicase family that is involved in biogenesis of the ribosome, particularly the small (40S) subunit; caspofungin-downregulated CAALFM_C504770WA Ortholog(s) have mitochondrion localization CAALFM_C504780WA Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity CAALFM_C504790CA Ortholog(s) have role in double-strand break repair via homologous recombination, meiosis I and Smc5-Smc6 complex, cytosol, nucleus localization CAALFM_C504800WA CRH family cell wall protein; transcript regulated by Nrg1 and Tup1; alkaline induced by Rim101; repressed during cell wall regeneration; flow model biofilm induced CAALFM_C504810WA Phosphofructokinase alpha subinit; activated by fructose 2,6-bisphosphate, AMP, ATP inhibited; activity reduced on hyphal induction; phagocytosis-repressed; fluconazole, flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C504830WA Transcription factor involved in regulation of morphogenesis; required for filamentous growth, for virulence in RHE model but not in mice; induced upon RHE infection but C. dubliniensis ortholog is not; Spider biofilm induced CAALFM_C504840CA Putative ribosome biogenesis factor; possibly essential, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced CAALFM_C504850WA Protein of unknown function; early-stage flow model biofilm induced CAALFM_C504860CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, retrograde transport, endosome to Golgi and ER to Golgi transport vesicle, Golgi cis cisterna, Golgi membrane, endoplasmic reticulum localization CAALFM_C504870WA Ortholog of Hua1, a zinc finger domain protein with sequence similarity to Type I J-proteins; flow model biofilm induced CAALFM_C504880CA Putative delta-1-pyrroline-5-carboxylate dehydrogenase; alkaline upregulated; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm induced; Spider biofilm induced CAALFM_C504890CA Ortholog(s) have structural constituent of cytoskeleton activity, role in establishment of mitotic spindle orientation, nuclear migration and astral microtubule, cell cortex, dynactin complex, spindle pole body localization CAALFM_C504900CA Protein with a role in translation; flow model biofilm repressed CAALFM_C504910WA Protein required for maturation of 18S rRNA; rat catheter biofilm repressed CAALFM_C504920CA Ortholog(s) have mRNA binding activity, role in cytoplasmic translation, regulation of translation and cytosol, polysomal ribosome localization CAALFM_C504930CA Putative high-affinity maltose transporter; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline induced; Spider biofilm induced CAALFM_C504940WA Maltase; induced during growth on sucrose; induced by alpha pheromone in SpiderM medium; early-stage flow model biofilm indced CAALFM_C504950CA Protein with a predicted transcription factor BTF3 domain; flow model biofilm induced CAALFM_C504960WA Protein of unknown function; induced in core caspofungin response; induced in ssr1 mutant; induced by nitric oxide independent of Yhb1; Spider biofilm induced CAALFM_C504970CA Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Ppr1p, which is a transcription factor involved in the regulation of uracil biosynthesis genes CAALFM_C504980WA Putative adhesin-like protein; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced CAALFM_C504990WA Ortholog(s) have DNA-directed RNA polymerase activity, RNA polymerase III activity and role in tRNA transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase III promoter CAALFM_C505000CA Ortholog(s) have acylglycerol lipase activity, role in cellular lipid metabolic process and cytoplasm, nucleus localization CAALFM_C505010WA BLOC-1 complex subunit involved in endosomal maturation; Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis CAALFM_C505020CA Dolichyl-diphosphooligosaccharide-protein glycotransferase; predicted role in protein N-linked glycosylation, protein O-linked mannosylation; Spider biofilm repressed CAALFM_C505030CA Protease of the pH response pathway; likely to mediate activation of Rim101 via C-terminal cleavage; required for alkaline pH-induced hyphal growth and for normal chlamydospore formation; Hap43-repressed; flow model biofilm induced CAALFM_C505040WA Putative mannosyltransferase; similar to S. cerevisiae Gpi10p; has HKEXRF motif CAALFM_C505050WA Alcohol dehydrogenase; oxidizes ethanol to acetaldehyde; at yeast cell surface; immunogenic in humans/mice; complements S. cerevisiae adh1 adh2 adh3 mutant; fluconazole, farnesol-induced; flow model biofilm induced; Spider biofilm repressed CAALFM_C505060CA Ortholog(s) have Atg8 ligase activity, protein binding, bridging activity and role in C-terminal protein lipidation, CVT pathway, late nucleophagy, macroautophagy, mitophagy, piecemeal microautophagy of nucleus CAALFM_C505070WA Ortholog(s) have fungal-type vacuole membrane localization CAALFM_C505080WA Putative homeodomain transcription factor, involved in control of filamentous growth; null mutant is an adenine auxotroph; Spider biofilm induced; promoter bound by Bcr1, Tec1, Efg1, Ndt80 and Brg1 CAALFM_C505090WA Ortholog(s) have role in protein insertion into mitochondrial membrane from inner side and extrinsic component of mitochondrial inner membrane, mitochondrial matrix localization CAALFM_C505100CA Protein similar to S. cerevisiae Dun1p, which is a serine-threonine protein kinase involved in DNA damage cell-cycle checkpoint; induced under Cdc5p depletion CAALFM_C505110CA Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; similar to S. cerevisiae Tip20p CAALFM_C505120WA Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin D CAALFM_C505130CA Putative dephospho-CoA kinase; protein likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_C505140WA Ortholog(s) have cytosol, nucleus localization CAALFM_C505150CA Ortholog(s) have protein-lysine N-methyltransferase activity and role in peptidyl-lysine monomethylation, peptidyl-lysine trimethylation CAALFM_C505160CA Regulatory subunit of calcineurin B (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type resistance to fluconazole or to SDS; micafungin is fungicidal to null mutant CAALFM_C505170WA Ortholog(s) have poly(A) RNA binding, poly(A)-specific ribonuclease activity, role in nuclear-transcribed mRNA poly(A) tail shortening, postreplication repair and PAN complex localization CAALFM_C505180WA Similar to S. pombe mug180, a predicted esterase/lipase; highly induced during chlamydospore formation in both C. albicans and C. dubliniensis; flow model biofilm induced CAALFM_C505190WA Putative cyclin for Pho85 kinase; Gcn4-induced; suppresses toxicity of C. albicans Gcn4 overproduction in S. cerevisiae via increased Pho85-dependent phosphorylation and degradation of Gcn4; rat catheter and Spider biofilm induced CAALFM_C505200CA Putative protein of unknown function; Hap43p-repressed gene; S. cerevisiae ortholog YHR045W localizes to the endoplasmic reticulum CAALFM_C505210WA Planktonic growth-induced gene CAALFM_C505220WA heterotrimeric G protein alpha subunit; positive role in mating pheromone response; opaque-enriched transcript; transcript repressed by MTLa1-MTLalpha2; regulated by hemoglobin-responsive Hbr1 via MTL genes; rat catheter biofilm repressed CAALFM_C505230CA Putative ubiquinol-cytochrome-c reductase; amphotericin B induced; repressed by nitric oxide; protein level decreases in stationary phase cultures; Hap43-repressed; Spider biofilm repressed CAALFM_C505240CA Ortholog of C. dubliniensis CD36 : Cd36_54840, C. parapsilosis CDC317 : CPAR2_100270, Candida tenuis NRRL Y-1498 : cten_CGOB_00242 and Debaryomyces hansenii CBS767 : DEHA2D14058g CAALFM_C505250CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C505260WA Ortholog(s) have protein phosphatase regulator activity, role in negative regulation of DNA damage checkpoint, protein dephosphorylation and cytoplasm, nucleus, protein phosphatase 4 complex localization CAALFM_C505270CA Ortholog of C. dubliniensis CD36 : Cd36_54870, C. parapsilosis CDC317 : CPAR2_100250, Debaryomyces hansenii CBS767 : DEHA2D13992g and Pichia stipitis Pignal : PICST_40400 CAALFM_C505280CA Succinate dehydrogenase, membrane subunit; induced in high iron CAALFM_C505290CA Protein similar to S. cerevisiae Mrp2p, which is a component of the small subunit of the mitochondrial ribosome; transposon mutation affects filamentous growth CAALFM_C505300WA Putative riboflavin synthase; fungal-specific (no human or murine homolog); farnesol-downregulated; protein present in exponential and stationary growth phase yeast cultures CAALFM_C505310WA Putative beta 4 subunit of the 20S proteasome; Rim101-induced at acid pH; flucytosine induced; amphotericin B repressed CAALFM_C505320CA ATP phosphoribosyl transferase; enzyme of histidine biosynthesis; acid upregulated/alkaline repressed by Rim101; regulated by Gcn2, Gcn4; strain CA9 is a his1 mutant; flow model biofilm induced; Spider biofilm repressed CAALFM_C505330CA Putative cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; flow model biofilm induced CAALFM_C505340WA Ortholog(s) have unfolded protein binding activity, role in ribosomal large subunit assembly and cytosol, cytosolic ribosome, nucleus, preribosome, large subunit precursor localization CAALFM_C505350WA Ortholog(s) have DNA primase activity, single-stranded DNA binding activity, role in DNA replication, synthesis of RNA primer and alpha DNA polymerase:primase complex, nuclear chromatin localization CAALFM_C505360CA Ortholog(s) have steryl-beta-glucosidase activity, role in ergosteryl 3-beta-D-glucoside catabolic process and cytosol localization CAALFM_C505370CA Putative RNA-dependent ATPase; induced upon adherence to polystyrene; induced by Mnl1p under weak acid stress CAALFM_C505380WA Putative COP9 signalosome component; macrophage/pseudohyphal-repressed CAALFM_C505390CA GPI-anchored cell surface protein; beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; transcript induced in RHE model of oral candidiasis; fluconazol-induced CAALFM_C505400WA Ortholog of S. cerevisiae/S. pombe Apm1; a clathrin-associated protein complex (AP-1) subunit; phosphorylated protein; Tn mutation affects filamentous growth; Spider biofilm repressed CAALFM_C505410CA Dihydroxyacid dehydratase; repressed by nitric oxide; macrophage-induced protein; protein in exponential and stationary growth phase; Sef1, Sfu1p, Hap43-regulated; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C505430WA Putative peroxisomal ubiquitin conjugating enzyme; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm induced; Spider biofilm induced CAALFM_C505440CA Protein with a predicted pleckstrin homology domain; induced by alpha pheromone in SpiderM medium CAALFM_C505450CA Protein similar to S. cerevisiae Mum2, a protein essential for meiotic DNA replication and sporulation; induced by alpha pheromone in SpiderM medium; transcript regulated by Tup1 CAALFM_C505460CA Putative transcription factor containing a Zn(2)-Cys(6) binuclear cluster CAALFM_C505470WA Telomerase subunit; allosteric activator of catalytic activity, but not required for catalytic activity; has TPR domain CAALFM_C505480WA Putative delta-4 sphingolipid desaturase; planktonic growth-induced gene CAALFM_C505490CA Putative tRNA-His synthetase; downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein; Spider biofilm repressed CAALFM_C505500CA Putative transcription factor; positive regulator of gene expression; Efg1-repressed; member of a family of telomere-proximal genes; transcript upregulated in RHE model of oral candidiasis CAALFM_C505510CA Protein similar to S. cerevisiae Ybr075wp; transposon mutation affects filamentous growth; clade-associated gene expression CAALFM_C600010WA Transcription factor; transposon mutation affects filamentous growth CAALFM_C600030WA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo; overlaps orf19.6337.1, which is a region annotated as blocked reading frame CAALFM_C600070CA Putative GPI-anchored adhesin-like protein; fluconazole-downregulated; induced in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C600080CA Protein of unknown function; opaque-specific transcript; fluconazole-repressed; induced in cyr1 mutant and in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C600090WA Putative protein of the mitochondrial intermembrane space; predicted role in acetate utilization and gluconeogenesis; Spider biofilm repressed CAALFM_C600100CA Putative sphingolipid transfer protein; involved in localization of glucosylceramide which is important for virulence; Spider biofilm repressed CAALFM_C600110CA Ortholog of C. dubliniensis CD36 : Cd36_60130, C. parapsilosis CDC317 : CPAR2_603380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94402 and Debaryomyces hansenii CBS767 : DEHA2G06556g CAALFM_C600120WA Ortholog(s) have mitochondrion localization CAALFM_C600130CA Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog) CAALFM_C600140CA Ortholog(s) have D-amino-acid N-acetyltransferase activity, role in D-amino acid metabolic process, cellular detoxification of nitrogen compound and cytosol, nucleus localization CAALFM_C600150WA D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; rat catheter and Spider biofilm induced CAALFM_C600160WA Putative GPI-anchored adhesin-like protein; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcript induced in high iron; flow model biofilm induced; Spider biofilm repressed CAALFM_C600170CA Ortholog(s) have mRNA binding, ubiquitin-specific protease activity and role in protein deubiquitination, regulation of ER to Golgi vesicle-mediated transport, regulation of response to osmotic stress, ribophagy CAALFM_C600180CA Putative transcription factor with bZIP DNA-binding motif; Hap43p-repressed gene CAALFM_C600190WA Ortholog of S. cerevisiae Rtt106; histone chaperone that regulates chromatin structure in transcribed and silenced chromosomal regions; affects transcriptional elongation; Hap43-repressed; Spider biofilm repressed CAALFM_C600200CA Protein of unknown function; induced in high iron; possibly subject to Kex2 processing; Hap43-repressed CAALFM_C600210WA Putative 2-aminoadipate transaminase; rat catheter and Spider biofilm repressed CAALFM_C600230WA Has domain(s) with predicted catalytic activity and membrane localization CAALFM_C600240CA Ortholog(s) have SNAP receptor activity, phosphatidylinositol-3-phosphate binding activity and role in CVT pathway, macroautophagy, piecemeal microautophagy of nucleus, vacuole fusion, non-autophagic, vesicle fusion CAALFM_C600250WA Ortholog(s) have fungal-type vacuole localization CAALFM_C600260WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_C600270WA Has domain(s) with predicted role in attachment of GPI anchor to protein and GPI-anchor transamidase complex localization CAALFM_C600280WA Myc-bHLH transcription factor; promotes hyphal growth; directly regulates Tec1 to induce hypha-specific genes; probably homodimeric, phosphorylated; required for colonization of the mouse GI tract; rat catheter and Spider biofilm induced CAALFM_C600290WA Protein of unknown function; regulated by yeast-hypha switch; induced by Mnl1 in weak acid stress; 5' UTR intron; repressed by chlamydospore formation in C. albicans and C. dubliniensis; rat catheter, Spider and flow model biofilm induced CAALFM_C600300CA Predicted subunit a of vacuolar proton-translocating ATPase V0 domain, Golgi isoform CAALFM_C600310WA Ortholog(s) have ubiquitin-protein transferase activity and role in ER-associated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol CAALFM_C600320CA Protein similar to S. cerevisiae Dna2p, which is a DNA replication factor involved in DNA repair; induced under hydroxyurea treatment CAALFM_C600330CA Similar to asparagine and glutamine permease; fluconazole, caspofungin induced; regulated by Nrg1, Mig1, Tup1, Gcn2, Gcn4, and alkaline regulated by Rim101; repressed during chlamydospore formation; rat catheter, flow model biofilm induced CAALFM_C600340CA Ortholog(s) have metalloendopeptidase activity, role in cellular iron ion homeostasis, protein processing involved in protein targeting to mitochondrion, protein stabilization and mitochondrial matrix localization CAALFM_C600350WA Ortholog(s) have protein kinase activity and role in MAPK cascade involved in cell wall organization or biogenesis CAALFM_C600360CA Predicted mitochondrial intermembrane space protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C600370CA Ortholog of S. cerevisiae Nop58; involved in pre-rRNA process; Tn mutation affects filamentous growth; macrophage/pseudohyphal-induced; physically interacts with TAP-tagged Nop1; Spider biofilm repressed CAALFM_C600380CA Protein of unknown function; Spider biofilm induced CAALFM_C600390WA Ortholog(s) have serine-tRNA ligase activity, role in invasive growth in response to glucose limitation, mitochondrial seryl-tRNA aminoacylation, pseudohyphal growth and mitochondrion localization CAALFM_C600400CA Ortholog of C. dubliniensis CD36 : Cd36_60350, C. parapsilosis CDC317 : CPAR2_603550, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114325 and Debaryomyces hansenii CBS767 : DEHA2G04950g CAALFM_C600410CA Protein with a predicted role in docking and fusion of post-Golgi vesicles with the plasma membrane; filament induced; fungal-specific (no human or murine homolog) CAALFM_C600420WA Dolichol-phosphate mannose synthase subunit, not essential for enzyme activity; flow model and Spider biofilm repressed CAALFM_C600430CA Phosphorylated protein of unknown function; transcript is upregulated clinical isolates from HIV positive patients with oral candidiasis CAALFM_C600440CA Multicopper ferroxidase; induced by low iron, ciclopirox olamine, ketoconazole, hypoxia; alkaline induced by Rim101; repressed in fluconazole-resistant isolate; Sfu1, Hog1 repressed; complements S. cerevisiae fet3; Spider biofilm induced CAALFM_C600460CA Multicopper oxidase; required for growth in low iron and prostaglandin E2 synthesis CAALFM_C600470CA Multicopper oxidase family protein; similar to S. cerevisiae Fet3; does not complement S. cerevisiae fet3 mutant growth under low-iron; iron-repressed; regulated by Tup1, Rim101; flow model biofilm induced; Spider biofilm repressed CAALFM_C600480CA Putative multicopper oxidase; ketoconazole/caspofungin/amphotericin B repressed; Sef1/Sfu1/Hap43 regulated; reports differ if functional homolog of ScFet3; rat catheter and Spider biofilm induced CAALFM_C600490WA Ortholog(s) have phospholipase A2 activity, role in cardiolipin acyl-chain remodeling and mitochondrial inner membrane localization CAALFM_C600500CA Ortholog(s) have NEDD8 activating enzyme activity, role in protein neddylation and cytosol, nucleus localization CAALFM_C600510CA Required for homologous DNA recombination, repair of UV- or MMS-damaged DNA, telomere length, UV-induced LOH; constitutive expression, MMS-induced; weakly complements S. cerevisiae rad52 mutant; slow growth, increased white-to-opaque switch CAALFM_C600520WA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis CAALFM_C600530CA Ortholog(s) have role in mRNA splicing, via spliceosome and U1 snRNP, U2 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol localization CAALFM_C600540WA Ortholog(s) have crossover junction endodeoxyribonuclease activity, enzyme inhibitor activity CAALFM_C600550WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C600560WA Ortholog(s) have role in nuclear pore organization, spindle pole body duplication and nuclear pore transmembrane ring, spindle pole body localization CAALFM_C600570CA Protein similar to S. cerevisiae Nhx1p, which is an Na+/H+ exchanger required for intracellular sequestration of Na+ CAALFM_C600590WA Protein involved in ER-to-Golgi transport; rat catheter and Spider biofilm induced CAALFM_C600600CA Predicted carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion; alkaline induced; Spider biofilm repressed CAALFM_C600620WA Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron CAALFM_C600630WA Ortholog of C. dubliniensis CD36 : Cd36_60540, C. parapsilosis CDC317 : CPAR2_602830, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108530 and Debaryomyces hansenii CBS767 : DEHA2F15532g CAALFM_C600640CA Putative TFIIH complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C600650CA Putative ribosomal protein of the small subunit CAALFM_C600660CA Ortholog(s) have role in actin filament debranching, negative regulation of Arp2/3 complex-mediated actin nucleation and actin cortical patch, nucleus localization CAALFM_C600670WA Protein involved in exit from mitosis and morphogenesis; ortholog of S. cerevisiae Cdc14p, which is a dual-specificity phosphatase and cell-cycle regulator; suppresses S. cerevisiae cdc15-lyt1, dbf2-2, and (partially) tem1 mutant phenotypes CAALFM_C600680CA Ortholog of C. parapsilosis CDC317 : CPAR2_602880, C. dubliniensis CD36 : Cd36_60590, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115034 and Debaryomyces hansenii CBS767 : DEHA2F15334g CAALFM_C600690WA Ortholog of C. dubliniensis CD36 : Cd36_60600, C. parapsilosis CDC317 : CPAR2_602890, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135512 and Debaryomyces hansenii CBS767 : DEHA2F15312g CAALFM_C600700CA Putative CTD phosphatase; role in dephosphorylation of RNA polymerase II C-terminal domain, transcription from RNA polymerase II promoter; flow model biofilm induced CAALFM_C600710WA Ortholog(s) have role in protein folding in endoplasmic reticulum and integral component of endoplasmic reticulum membrane, mitochondrion localization CAALFM_C600720CA Cytochrome oxidase assembly protein; transcript regulated by Nrg1 and Tup1; alkaline repressed; Hap43-repressed; early-stage flow model biofilm induced; Spider biofilm repressed CAALFM_C600730WA Ortholog of C. dubliniensis CD36 : Cd36_60640, C. parapsilosis CDC317 : CPAR2_602930, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115038 and Pichia stipitis Pignal : PICST_31932 CAALFM_C600740WA Predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm CAALFM_C600750CA Phosphoglycerate kinase; localizes to cell wall and cytoplasm; antigenic in murine/human infection; flow model biofilm, Hog1-, Hap43-, GCN-induced; repressed upon phagocytosis; repressed in Spider biofilms by Bcr1, Ndt80, Rob1, Brg1 CAALFM_C600760WA Ortholog(s) have adenyl-nucleotide exchange factor activity, role in cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, cytoplasmic translation and cytosolic ribosome, nucleus localization CAALFM_C600770CA Ortholog(s) have crossover junction endodeoxyribonuclease activity and role in DNA repair, DNA topological change, regulation of reciprocal meiotic recombination, resolution of meiotic recombination intermediates CAALFM_C600780WA Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip CAALFM_C600790CA Copper transporter; transcribed in low copper; induced Mac1, Tye7, macrophage interaction, alkaline pH via Rim101; 17-beta-estradiol repressed; complements S. cerevisiae ctr1 ctr3 copper transport mutant; flow model/Spider biofilm induced CAALFM_C600800CA Protein of unknown function; Cyr1-repressed; rat catheter and Spider biofilm induced CAALFM_C600810CA Protein of unknown function; Hap43-repressed gene CAALFM_C600820WA Cell wall glycosidase; role in biofilm formation and cell separation; possibly secreted; hypoxia, hyphal induced; caspofungin repressed; Efg1, Cph1 regulated; O-glycosylated, possible Kex2 substrate; 5'-UTR intron; Spider biofilm induced CAALFM_C600830CA Predicted amino acid transmembrane transporter; transcript regulated by white-opaque switch; Hap43-repressed gene CAALFM_C600840WA Similar to glutathione peroxidase; induced in high iron; alkaline induced by Rim101; induced by alpha factor or interaction with macrophage; regulated by Efg1; caspofungin repressed; Spider biofilm induced CAALFM_C600850WA Putative glutathione peroxidase; induced by peroxide, exposure to neutrophils and macrophage blood fractions; repressed during infection of macrophages; Spider biofilm induced; flow model biofilm repressed CAALFM_C600860WA Putative thiol peroxidase; rat catheter and Spider biofilm induced CAALFM_C600870CA Ketol-acid reductoisomerase; antigenic; regulated by Gcn4; GlcNAc, amino acid starvation (3-AT)-induced; macrophage-repressed protein; protein present in exponential and stationary phase; flow model and Spider biofilm repressed CAALFM_C600880WA Ortholog(s) have peroxisome matrix targeting signal-2 binding activity, role in fatty acid metabolic process, protein import into peroxisome matrix, docking and cytosol, nucleus, peroxisome localization CAALFM_C600890WA Ortholog(s) have cytoplasm localization CAALFM_C600900CA Protein of unknown function; flow model biofilm induced; Hap43-repressed CAALFM_C600910CA Protein with a predicted thioredoxin-like domain; Hap43-repressed; induced by prostaglandins CAALFM_C600920WA Putative mitochondrial intermembrane space protein; colony morphology-related gene regulation by Ssn6; regulated by Sef1, Sfu1, and Hap43; Spider biofilm repressed; rat catheter biofilm induced CAALFM_C600930CA Protein of unknown function; Spider biofilm induced CAALFM_C600940CA Ortholog of S. cerevisiae : PRM5, C. dubliniensis CD36 : Cd36_60980, C. parapsilosis CDC317 : CPAR2_603060, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113703 and Debaryomyces hansenii CBS767 : DEHA2F10032g CAALFM_C600950CA DNA topoisomerase I; required for wild-type growth and for wild-type mouse virulence; sensitive to camptothecin; induced upon adherence to polystyrene; rat catheter biofilm induced CAALFM_C600960WA Basic amino acid permease; complements lysine transport mutation; 10 predicted transmembrane regions, 3 predicted N-glycosylation sites; phagocytosis by macrophages induces transcript; rat catheter, Spider and flow model biofilm induced CAALFM_C600970CA Putative phosphoadenosine-5'-phosphate or 3'-phosphoadenosine 5'-phosphosulfate phosphatase; possible role in sulfur recycling; ortholog of S. cerevisiae Met22; predicted Kex2 substrate; F-12/CO2 biofilm induced CAALFM_C600980CA Alpha/beta hydrolase and lipase domain protein; Hap43-repressed; Spider and flow model biofilm induced CAALFM_C600990WA Protein required for alkaline pH response via the Rim101 signaling pathway; ortholog of S. cerevisiae Rim9 and A. nidulans palI; Spider biofilm induced CAALFM_C601000CA Ortholog(s) have translation regulator activity, role in regulation of translation and mitochondrion localization CAALFM_C601010WA Ortholog of S. cerevisiae Kar5; involved in nuclear membrane fusion during karyogamy; induced by alpha factor CAALFM_C601020WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C601030WA Putative phosphoadenosine-5'-phosphate or 3'-phosphoadenosine 5'-phosphosulfate phosphatase; possible role in sulfur recycling; Hap43-repressed; F-12/CO2 biofilm induced CAALFM_C601040CA DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis; rat catheter biofilm induced CAALFM_C601050WA Probable mitochondrial tyrosyl-tRNA synthetase, based on conservation in other fungi CAALFM_C601060CA Basic amino acid permease; arginine metabolism; regulated by Nrg1/Tup1; caspofungin, flucytosine induced; colony morphology-related regulation by Ssn6; Hap43-repressed; rat catheter and Spider biofilm induced; promoter bound by Efg1 CAALFM_C601070CA Possible oxidoreductase; transcript induced by cadmium but not other heavy metals, heat shock, yeast-hypha switch, oxidative stress (via Cap1), or macrophage interaction; stationary phase enriched protein; Spider biofilm induced CAALFM_C601080CA Ortholog of C. dubliniensis CD36 : Cd36_61190, C. parapsilosis CDC317 : CPAR2_603230, Candida tenuis NRRL Y-1498 : cten_CGOB_00054 and Debaryomyces hansenii CBS767 : DEHA2E21142g CAALFM_C601090CA Ortholog of Candida tropicalis MYA-3404 : CTRG_02973 and Candida albicans WO-1 : CAWG_05252 CAALFM_C601100WA t-SNARE protein required for secretory vesicle-membrane fusion CAALFM_C601110WA Delta-12 fatty acid desaturase, involved in production of linoleic acid, which is a major component of membranes CAALFM_C601120CA Ortholog(s) have protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity, role in C-terminal protein methylation, peptide pheromone maturation and endoplasmic reticulum membrane, nuclear inner membrane localization CAALFM_C601130WA Has domain(s) with predicted protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity, role in C-terminal protein methylation and integral component of membrane localization CAALFM_C601140CA Putative ARP2/3 complex subunit; mutation confers hypersensitivity to cytochalasin D CAALFM_C601150WA Activator of anaphase-promoting complex/cyclosome; induced under Cdc5 depletion; member of conserved Mcm1 regulon; mRNA expression peaks at cell-cycle G2/M phase; mRNA binds She3 and is localized to buds of yeast cells and to hyphal tips CAALFM_C601160WA Protein involved in calcineurin-dependent signaling that controls stress response and virulence; inhibits calcineurin function CAALFM_C601170WA Putative proteasome-interacting protein; rat catheter biofilm induced CAALFM_C601180CA NADPH oxidoreductase; interacts with phenolic substrates (17beta-estradiol); possible role in estrogen response; induced by oxidative, weak acid stress, NO, benomyl, GlcNAc; Cap1, Mnl1 induced; Hap43-repressed; rat catheter biofilm induced CAALFM_C601190CA Protein involved in retrograde endosome-to-Golgi protein transport; required for normal virulence CAALFM_C601200WA Ortholog of C. dubliniensis CD36 : Cd36_61330, C. parapsilosis CDC317 : CPAR2_602800, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94450 and Debaryomyces hansenii CBS767 : DEHA2F15554g CAALFM_C601210WA Ortholog(s) have endoplasmic reticulum localization CAALFM_C601220CA Ortholog(s) have role in histone deacetylation, negative regulation of chromatin silencing at telomere, negative regulation of meiotic nuclear division, positive regulation of stress-activated MAPK cascade CAALFM_C601280WA Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip CAALFM_C601290CA Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); Hap43p-repressed gene CAALFM_C601300WA Putative transferase involved in phospholipid biosynthesis; induced by alpha pheromone in SpiderM medium CAALFM_C601310WA S. cerevisiae Fig1 ortholog; an integral membrane protein required for mating; role in thigmotropism; transcript is opaque-specific and a-specific; activated by Cph1 or alpha pheromone CAALFM_C601320WA Subunit of the NuA4 histone acetyltransferase complex CAALFM_C601330CA Ortholog of C. dubliniensis CD36 : Cd36_61450, C. parapsilosis CDC317 : CPAR2_602710, Candida tenuis NRRL Y-1498 : cten_CGOB_00240 and Pichia stipitis Pignal : psti_CGOB_00191 CAALFM_C601340CA Putative mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); essential for cardiolipin biosynthesis; rat catheter biofilm induced CAALFM_C601350WA Ortholog(s) have ubiquitin-protein transferase activity, role in histone catabolic process, histone ubiquitination and cytoplasm, ribosome localization CAALFM_C601360WA Protein of unknown function; ketoconazole-repressed CAALFM_C601370WA Ortholog(s) have mannosyltransferase activity and role in ER-associated ubiquitin-dependent protein catabolic process, GPI anchor biosynthetic process, protein processing CAALFM_C601380CA Ortholog(s) have Ran GTPase binding activity, role in protein import into nucleus and nucleus localization CAALFM_C601390WA Protein with similarity to mannosyltransferases; similar to S. cerevisiae Hoc1p and C. albicans Och1p CAALFM_C601400WA Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS); Hap43p-repressed gene CAALFM_C601410CA Putative NAPDH dehydrogenase; induced by nitric oxide; Spider biofilm induced CAALFM_C601420CA Putative oxidoreductase; Hap43-repressed gene CAALFM_C601430CA Putative ammonia transport protein; regulated by Nrg1 and Tup1; regulated by Ssn6; induced by human neutrophils CAALFM_C601440CA Protein with a GPR1/FUN34/yaaH family domain; flucytosine repressed CAALFM_C601450CA Protein of unknown function; Cyr1-repressed; rat catheter and Spider biofilm induced CAALFM_C601460CA Ortholog(s) have chaperone binding activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein folding in endoplasmic reticulum, response to unfolded protein and endoplasmic reticulum lumen localization CAALFM_C601470WA Has domain(s) with predicted serine-type endopeptidase activity and role in proteolysis CAALFM_C601480WA Protein with a Rho GDP-dissociation inhibitor domain; macrophage-induced gene CAALFM_C601490CA Ortholog of Candida albicans WO-1 : CAWG_05215 CAALFM_C601500CA Zn(II)2Cys6 transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate CAALFM_C601510WA Putative NAPDH dehydrogenase; induced by nitric oxide, benomyl; oxidative stress-induced via Cap1; Hap43p-repressed; rat catheter biofilm induced CAALFM_C601520WA Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); induced by nitric oxide CAALFM_C601530CA Ortholog(s) have enzyme regulator activity, role in cation transport and plasma membrane localization CAALFM_C601550CA Ortholog(s) have 3'-5' exonuclease activity, DNA-directed DNA polymerase activity, role in mitochondrial DNA replication and mitochondrion localization CAALFM_C601560WA Plasma membrane-associated protein; physically interacts with TAP-tagged Nop1p CAALFM_C601570CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C601590WA Protein of unknown function; flow model biofilm induced CAALFM_C601610WA Translation initiation factor eIF-5A; repressed in hyphae vs yeast cells; downregulated upon phagocytosis by murine macrophage; Hap43-induced; GlcNAc-induced protein; Spider biofilm repressed CAALFM_C601620WA RING/FYVE/PHD zinc finger protein; Spider biofilm induced CAALFM_C601630WA Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C601640WA RNA polymerase II mediator complex subunit CAALFM_C601650CA Putative mitochondrial protein; mRNA binds She3 CAALFM_C601670WA Malic enzyme, mitochondrial; transcription regulated by Mig1, Tup1; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Spider biofilm repressed CAALFM_C601680CA Has domain(s) with predicted hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines, metal ion binding activity CAALFM_C601690WA Putative endo-1,3-beta-glucanase; fungal-specific (no human or murine homolog) CAALFM_C601700WA Component of the large (60S) ribosomal subunit; Spider biofilm repressed CAALFM_C601710CA Putative protein kinase of polyamine import; mutation confers hypersensitivity to high concentrations of tunicamycin; YPD flow model biofilm induced; rat catheter and Spider biofilm induced CAALFM_C601720CA Protein required for normal cell wall, plasma membrane, cytoskeletal organization, endocytosis; localizes to eisosome subdomains of plasma membrane; four transmembrane motifs; mutant shows ectopic, chitin-rich cell wall; fluconazole-induced CAALFM_C601730WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_C601740CA Putative lipase; fungal-specific (no human or murine homolog); Hap43p-repressed gene CAALFM_C601750CA Ortholog(s) have role in cellular bud site selection and cytosol, nucleus localization CAALFM_C601760WA Putative guanyl-nucleotide exchange factor; induced in high iron; Hap43-repressed CAALFM_C601770WA Putative transcription factor with zinc finger DNA-binding motif; Hap43p-repressed gene CAALFM_C601780CA Predicted chloride transporter; member of conserved Mcm1 regulon; Spider biofilm repressed CAALFM_C601790CA Putative Zn(II)2Cys6 transcription factor; heterozygous null mutant displays sensitivity to virgineone and decreased colonization of mouse kidneys CAALFM_C601810WA Protein of unknown function; transcription repressed by fluphenazine treatment CAALFM_C601820CA Formamidopyrimidine DNA glycosylase, involved in repair of gamma-irradiated DNA; Hap43p-repressed gene CAALFM_C601830WA Protein similar to S. cerevisiae Mos10p, which affects S. cerevisiae filamentous growth; activates transcription in 1-hybrid assay in S. cerevisiae; protein levels increase under weak acid stress; nonessential CAALFM_C601840CA Protein with a predicted role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophages; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C601850WA Ortholog(s) have histone binding activity, role in histone exchange and Swr1 complex, cytoplasm localization CAALFM_C601860CA Ortholog of S. cerevisiae Hch1, a regulator of heat shock protein Hsp90; regulated by Gcn4; induced in response to amino acid starvation (3-aminotriazole treatment); mutants are viable CAALFM_C601870CA Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; induced by nitric oxide, oxidative stress, alpha pheromone; fungal-specific; Hap43-repressed; Spider biofilm induced CAALFM_C601880WA Predicted membrane protein; induced by alpha pheromone in SpiderM medium CAALFM_C601890CA Putative DEAD-box helicase; Hap43-induced; Spider biofilm induced CAALFM_C601900CA Putative 2-deoxyglucose-6-phosphatase; haloacid dehalogenase hydrolase/phosphatase superfamily; similar to S. cerevisiae Dog1, Dog2, Hor1, Rhr2; regulated by Nrg1, Tup1; Spider biofilm repressed CAALFM_C601910WA Putative adenylate kinase; repressed in hyphae; macrophage-induced protein; adenylate kinase release used as marker for cell lysis; possibly essential (UAU1 method); flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_C601920CA Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C601930WA Putative mitochondrial carrier protein; fungal-specific (no human or murine homolog); Hap43p-repressed gene CAALFM_C601940WA Ortholog of C. parapsilosis CDC317 : CPAR2_602135, Candida tenuis NRRL Y-1498 : cten_CGOB_00042, Debaryomyces hansenii CBS767 : DEHA2F11858g and Pichia stipitis Pignal : PICST_60705 CAALFM_C601950CA Protein of unknown function; regulated by Nrg1 CAALFM_C601960WA Ortholog of C. dubliniensis CD36 : Cd36_62090, C. parapsilosis CDC317 : CPAR2_602150, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112751 and Debaryomyces hansenii CBS767 : DEHA2F11814g CAALFM_C601970CA Putative rRNA-binding ribosomal protein component of the 60S ribosomal subunit; Hap43-induced; colony morphology-related gene regulation by Ssn6 CAALFM_C601980CA Mitochondrial ribosomal protein of the small subunit; S. cerevisiae ortholog is essential for viability; Spider biofilm repressed CAALFM_C601990WA Phospholipase B; host cell penetration and virulence in mouse systemic infection; Hog1-induced; signal sequence, N-glycosylation, and Tyr phosphorylation site; induced in fluconazole-resistant strains; rat catheter biofilm repressed CAALFM_C602000WA Putative phospholipase B; conserved catalytic region; 6 putative N-glycosylation motifs; predicted secretion signal; no GPI anchor predicted; fungal-specific (no human or murine homolog) CAALFM_C602010CA Surface protein similar to glycerol 3-P dehydrogenase; binds host Factor H, FHL-1, plasminogen; regulated by Ssn6, Nrg1, Efg1; induced by cell wall regeneration, macrophage/pseudohyphal growth, core stress response; Spider biofilm induced CAALFM_C602020CA Protein of unknown function; Hap43-repressed gene; rat catheter and Spider biofilm induced CAALFM_C602030CA Putative protein of unknown function; stationary phase enriched protein CAALFM_C602040WA NADH-cytochrome-b5 reductase; soluble in hyphae; alkaline downregulated; farnesol, ketoconazole or flucytosine induced; protein present in exponential and stationary growth phase yeast; YNB biofilm induced; rat catheter biofilm repressed CAALFM_C602050WA Debranchase; homozygous mutant accumulates lariat intermediates of mRNA splicing; rat catheter biofilm repressed CAALFM_C602060WA Ortholog(s) have role in TOR signaling, actin filament bundle assembly, eisosome assembly, endosomal transport and establishment of protein localization to plasma membrane, more CAALFM_C602070CA Ribosomal protein; downregulated upon phagocytosis by murine macrophage; Hap43-induced; sumoylation target; Spider biofilm repressed CAALFM_C602090CA S. cerevisiae ortholog Pxl1 localizes to sites of polarized growth and is required for selection and/or maintenance of polarized growth sites; Hog1p-repressed CAALFM_C602100WA Secreted potein; Hap43-repressed; fluconazole-induced; regulated by Tsa1, Tsa1B under H2O2 stress conditions; induced by Mnl1p under weak acid stress; Spider biofilm induced CAALFM_C602110WA Ortholog of C. dubliniensis CD36 : Cd36_62270, C. parapsilosis CDC317 : CPAR2_602240, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114419 and Debaryomyces hansenii CBS767 : DEHA2E04884g CAALFM_C602120WA Clathrin heavy chain; subunit of the major coat protein; role in intracellular protein transport and endocytosis; flow model and rat catheter biofilm repressed CAALFM_C602130CA Predicted component of the kinetochore sub-complex COMA; induced during the mating process; repressed by alpha pheromone in SpiderM medium CAALFM_C602140WA Ortholog(s) have cellular bud tip, cytoplasm localization CAALFM_C602150CA Putative mitochondrial inner membrane magnesium transporter; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C602160WA Protein with a predicted serine/threonine kinase and tyrosine kinase domain; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C602170CA Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity, role in chromatin silencing at telomere, histone H3-K4 methylation, telomere maintenance and Set1C/COMPASS complex localization CAALFM_C602180WA Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole and Golgi apparatus, Vps55/Vps68 complex, fungal-type vacuole membrane, mitochondrion localization CAALFM_C602190CA Putative serine/threonine/tyrosine (dual-specificity) kinase; disruptants not obtained by UAU1 method CAALFM_C602200CA Protein of unknown function; mRNA binds She3; transcript regulated upon yeast-hypha switch; induced in oralpharyngeal candidasis CAALFM_C602210WA Protein of unknown function; oxidative stress-induced via Cap1; induced by alpha pheromone in SpiderM medium CAALFM_C602220WA Functional homolog of S. cerevisiae Sar1; which is required for ER-to-Golgi protein transport; binds GTP; similar to small GTPase superfamily proteins; gene has intron; Hap43-induced; rat catheter biofilm repressed CAALFM_C602230WA Putative GTPase; role in 60S ribosomal subunit biogenesis; Spider biofilm induced CAALFM_C602240CA Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed CAALFM_C602250WA Predicted methyltransferase; downregulated by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 CAALFM_C602260CA Ortholog(s) have ubiquitin binding activity CAALFM_C602270CA Alpha-1,2-mannosyltransferase; catalyzes sequential addition of 2 terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; Spider biofilm induced CAALFM_C602280WA S. cerevisiae ortholog Stb1 has a role in regulation of MBF-specific transcription at Start; induced in a cyr1 null mutant; Spider biofilm induced CAALFM_C602290CA Putative flavodoxin; similar to S. cerevisiae Tyw1, an iron-sulfur protein required for synthesis of wybutosine modified tRNA; predicted Kex2p substrate; Spider biofilm induced CAALFM_C602300CA Protein with a predicted anaphase-promoting complex APC subunit 1 CDC26 domain; Hap43-repressed gene CAALFM_C602310WA Ortholog(s) have enzyme activator activity, histone acetyltransferase activity, structural molecule activity CAALFM_C602320CA Putative Aurora kinase; Hap43-induced; induced during planktonic growth; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C602330WA Described as a Gag-related protein; hyphal induced; downregulation correlates with clinical development of fluconazole resistance; repressed by nitric oxide, 17-beta-estradiol, ethynyl estradiol CAALFM_C602340WA Predicted protein serine/threonine kinase; Spider biofilm induced CAALFM_C602350CA Putative pseudouridine synthase; predicted role in snRNA pseudouridine synthesis, tRNA pseudouridine synthesis; Spider biofilm induced CAALFM_C602360WA Putative nucleolar protein with role in ribosomal assembly; hyphal-induced; Hap43-induced; Spider biofilm induced CAALFM_C602370CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C602380WA Putative mitochondrial ATP-dependent RNA helicase of the DEAD-box family, transcription is activated in the presence of elevated CO2 CAALFM_C602410WA Ortholog(s) have NAD+ diphosphatase activity, role in NADH metabolic process and peroxisome localization CAALFM_C602420WA Putative phosphatidyl glycerol phospholipase C; Plc1-regulated; flow model biofilm induced; Spider biofilm induced CAALFM_C602430WA Ortholog(s) have role in chromatin silencing at telomere, negative regulation of transcription from RNA polymerase II promoter by pheromones and CHRAC localization CAALFM_C602440CA Protein required for pre-mRNA splicing; Spider biofilm induced CAALFM_C602450WA Ortholog of S. pombe SPCC550.08, an N-acetyltransferase; transcript induced during growth in the mouse cecum CAALFM_C602460CA Ortholog(s) have ribosome binding activity and role in mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation CAALFM_C602470WA Ortholog(s) have role in SRP-dependent cotranslational protein targeting to membrane, translocation and signal recognition particle, endoplasmic reticulum targeting localization CAALFM_C602480WA Similar to alcohol dehydrogenases; induced by benomyl treatment, nitric oxide; induced in core stress response; oxidative stress-induced via Cap1; Spider biofilm repressed CAALFM_C602490CA Protein of unknown function; Spider biofilm induced CAALFM_C602500CA Putative T subunit of glycine decarboxylase; transcript negatively regulated by Sfu1; Spider biofilm repressed CAALFM_C602510CA a-cell specific protein of unknown function; two predicted transmembrane domains; member of conserved Mcm1 regulon; induced by alpha pheromone in SpiderM medium CAALFM_C602520WA Putative mitochondrial iron-sulfur protein; alkaline repressed; induced in high iron; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced CAALFM_C602530CA Ortholog of C. dubliniensis CD36 : Cd36_62760, C. parapsilosis CDC317 : CPAR2_601700, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115220 and Debaryomyces hansenii CBS767 : DEHA2A06666g CAALFM_C602540CA Ortholog of C. dubliniensis CD36 : Cd36_62780, C. parapsilosis CDC317 : CPAR2_601690, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113271 and Debaryomyces hansenii CBS767 : DEHA2A06644g CAALFM_C602550WA Ortholog of C. dubliniensis CD36 : Cd36_62790, C. parapsilosis CDC317 : CPAR2_601680, Candida tenuis NRRL Y-1498 : cten_CGOB_00252 and Debaryomyces hansenii CBS767 : DEHA2A06622g CAALFM_C602560WA Putative oxidoreductase; protein levels affected by URA3 expression in CAI-4 strain background; Efg1, Efh1 regulated; Rgt1-repressed; protein present in exponential and stationary growth phase yeast; rat catheter biofilm repressed CAALFM_C602570CA Essential protein; similar to S. cerevisiae Sec20p; depletion causes membrane accumulation and drug sensitivity; expression regulated by growth phase; O-mannosylation regulates proteolysis; does not complement S. cerevisiae sec20-1 mutant CAALFM_C602580WA Protein with a predicted role in 5.8S rRNA processing; flow model biofilm induced CAALFM_C602590CA Putative mitotic exit network component; periodic mRNA expression, peak at cell-cycle G2/M phase CAALFM_C602600WA Putative nuclear polyadenylated RNA-binding protein; flucytosine repressed CAALFM_C602610CA Chaperone for Crk1p; interacts with Crk1p kinase domain and with Sti1p; putative phosphorylation site at Ser14; functional homolog of S. cerevisiae Cdc37p; likely to be essential for growth; regulated by Gcn2p and Gcn4p CAALFM_C602620CA Protein of unknown function; Spider biofilm induced CAALFM_C602630CA Ortholog(s) have guanyl-nucleotide exchange factor activity, ubiquitin binding activity CAALFM_C602640CA Protein with a predicted role in mitotic spindle elongation, vesicle-mediated transport; flow model biofilm induced CAALFM_C602650CA Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS) CAALFM_C602660CA Has domain(s) with predicted carbon-nitrogen ligase activity, with glutamine as amido-N-donor activity CAALFM_C602670CA Putative cell wall integrity and stress response protein; mRNA binds She3; Spider biofilm induced CAALFM_C602680WA Ortholog(s) have SNAP receptor activity, role in retrograde vesicle-mediated transport, Golgi to ER and SNARE complex, integral component of cytoplasmic side of endoplasmic reticulum membrane localization CAALFM_C602690CA Protein with similarity to S. pombe Nrd1p; transcription induced upon induction of hyphal growth; regulated by Cph1p, Efg1p, Cph2p; low-level expression; alkaline upregulated; fungal-specific (no human or murine homolog) CAALFM_C602710CA Secreted aspartyl protease; expressed during hyphal growth, oral carriage, infection; sap4,5,6 triple mutant defective in protein utilization as N source; virulence role affecte by URA3; N-glycosylated; rat catheter biofilm induced CAALFM_C602720CA Has domain(s) with predicted zinc ion binding activity and role in intracellular protein transport, vesicle-mediated transport CAALFM_C602730WA Fimbrin; actin filament bundling protein; transcript regulated by Nrg1 and Mig1; protein level decreases in stationary phase CAALFM_C602740WA Protein of unknown function; Hap43-repressed gene CAALFM_C602750CA Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, which is a transcription factor involved in the regulation of lysine biosynthesis genes CAALFM_C602760WA Ortholog of C. dubliniensis CD36 : Cd36_63380 and Candida albicans WO-1 : CAWG_05071 CAALFM_C602770WA Putative mRNA turnover protein; Hap43-induced; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); rat catheter biofilm induced CAALFM_C602780CA Centromere-associated protein; similar to CENP-C proteins; Cse4p and Mif2p colocalize at C. albicans centromeres CAALFM_C602790CA Putative transcriptional regulator of ribonucleotide reductase genes; Spider biofilm induced CAALFM_C602800WA Ortholog(s) have methionine-R-sulfoxide reductase activity, role in cellular response to oxidative stress and cytoplasm, nucleus localization CAALFM_C602810CA Ortholog of C. dubliniensis CD36 : Cd36_63300, Candida tropicalis MYA-3404 : CTRG_05769 and Candida albicans WO-1 : CAWG_05077 CAALFM_C602830WA Mannosyltransferase; transcript upregulated in Ssk1 response regulator mutant or in nik1 null mutant, but not in chk1 or sln1 null mutants; pheromone induced; Spider biofilm induced CAALFM_C602840CA Transcription factor; glutamine-rich activation domain; binds RPG-box DNA sequences; predominantly nuclear; mutation causes accelerated induction of filamentous growth; antigenic during human oral infection; Sko1p-repressed CAALFM_C602850WA Protein similar to S. cerevisiae Rav2; a regulator of (H+)-ATPase in vacuolar membrane; transposon mutation affects filamentous growth CAALFM_C602860WA Ortholog of S. cerevisiae Ste23 metalloprotease; role in N-terminal processing of pro-a-factor to the mature form; Tn mutation affects filamentous growth; Spider biofilm induced CAALFM_C602870WA Ribonuclease H (RNAse H); hyphal-induced; flucytosine induced; similar to orf19.5564 (see Locus History); possibly essential (UAU1 method); rat catheter biofilm induced; flow model biofilm repressed CAALFM_C602880WA Has domain(s) with predicted RNA-DNA hybrid ribonuclease activity, nucleic acid binding activity CAALFM_C602890CA 3-hydroxypropionate dehydrogenase; involved in degradation of toxic propionyl-CoA; rat catheter and Spider biofilm induced CAALFM_C602900CA Ortholog(s) have role in protein lipoylation and mitochondrion localization CAALFM_C602910WA Ortholog of S. cerevisiae Pop4; a subunit of both RNase MRP and nuclear RNase P; filament induced; regulated by Nrg1, Tup1; likely essential, based on UAU1 strategy; rat catheter and Spider biofilm induced CAALFM_C602920CA Protein with a role in vacuolar function; null mutant has defect in damaging oral epithelial and vascular endothelial cells; required for normal hyphal growth and stress resistance; induced in presence of host oral or vascular cells CAALFM_C602930WA Ortholog(s) have role in maintenance of rDNA, mitotic sister chromatid segregation and chromosome, telomeric region, nuclear envelope localization CAALFM_C602940CA Protein of unknown function; Spider biofilm repressed CAALFM_C602950CA Protein of unknown function; expression downregulated in an ssr1 null mutant CAALFM_C602960WA Ortholog(s) have mitochondrial outer membrane localization CAALFM_C602970CA Putative peripheral peroxisomal membrane peroxin; required for regulating peroxisome size and maintenance; Spider biofilm induced CAALFM_C602980CA Putative pantothenate kinase; ortholog of S. cerevisiae Cab1; transposon mutation affects filamentous growth; repressed in core stress response CAALFM_C602990WA Ortholog of C. dubliniensis CD36 : Cd36_63050 and Candida albicans WO-1 : CAWG_05094 CAALFM_C603000CA Protein with a predicted double-strand break repair domain; Hap43-repressed gene CAALFM_C603010WA Ortholog(s) have protein serine/threonine kinase activity, telomeric DNA binding activity and role in DNA damage induced protein phosphorylation, double-strand break repair, histone phosphorylation, telomere maintenance CAALFM_C603020WA Peptidase; activity useful for strain identification by multilocus enzyme electrophoresis (MLEE); clade-associated gene expression CAALFM_C603030WA Secreted aspartyl proteinase; sap4,5,6 triple null defective in utilization of protein as N source; virulence role effected by URA3; expressed during infection; mRNA localized to hyphal tip via She3; rat catheter and Spider biofilm induced CAALFM_C603040CA Ortholog(s) have phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, role in phosphatidylinositol dephosphorylation and PAS complex, cytosol, fungal-type vacuole membrane, nuclear periphery localization CAALFM_C603050CA Protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis CAALFM_C603060WA Putative GPI-anchored adhesin-like protein; hyphal-induced expression CAALFM_C603070CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_C603080CA Adenosine kinase; heterozygous null mutant is resistant to cordycepin in C. albicans fitness test; ketoconazole-induced; protein level decrease in stationary phase cultures; sumoylation target; Spider biofilm repressed CAALFM_C603090WA Ortholog of C. dubliniensis CD36 : Cd36_63980, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115187, Candida tropicalis MYA-3404 : CTRG_02719 and Candida albicans WO-1 : CAWG_05060 CAALFM_C603100WA mRNA-binding protein that localizes specific mRNAs to daughter yeast cells and to hyphal tips; required for normal filamentation and host epithelial cell damage; ortholog of S. cerevisiae She3 but target mRNAs differs CAALFM_C603110CA Ortholog(s) have ASTRA complex localization CAALFM_C603120WA Putative DNA Polymerase phi; F-12/CO2 early biofilm induced CAALFM_C603130WA Has domain(s) with predicted proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism activity and role in ATP synthesis coupled proton transport CAALFM_C603140CA Putative mitochondrial, half-size MDR-subfamily ABC transporter CAALFM_C603150CA Ortholog(s) have extracellular region localization CAALFM_C603160CA Beta-mannosyltransferase; beta-1,2-mannosylation of phospholipomannan; member of a 9-member family including Bmt1, Bmt2, Bmt3, and Bmt4 with roles in mannosylation of cell wall phosphopeptidomannan; flow model biofilm induced CAALFM_C603170CA Plasma membrane MDR/MFS multidrug efflux pump; methotrexate is preferred substrate; overexpression in drug-resistant clinical isolates confers fluconazole resistance; repressed in young biofilms; rat catheter biofilm induced CAALFM_C603180CA Ortholog(s) have protein binding, bridging, ubiquitin protein ligase binding activity and role in positive regulation of ubiquitin-dependent endocytosis, regulation of intracellular transport CAALFM_C603200WA Ortholog of C. dubliniensis CD36 : Cd36_63860, C. parapsilosis CDC317 : CPAR2_601140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92714 and Debaryomyces hansenii CBS767 : DEHA2A06072g CAALFM_C603210CA RNA polymerase III subunit; Spider biofilm induced CAALFM_C603220WA Ortholog of C. dubliniensis CD36 : Cd36_63840, C. parapsilosis CDC317 : CPAR2_601510, Debaryomyces hansenii CBS767 : DEHA2A06270g and Pichia stipitis Pignal : PICST_31363 CAALFM_C603230WA Putative ornithine carbamoyltransferase; Gcn4-regulated; Hap43-induced; repressed in alkalinizing medium; rat catheter and Spider biofilm induced CAALFM_C603240WA Predicted 3-methylbutanol:NAD(P) oxidoreductase and methylglyoxal reductase (NADPH-dependent); role in ergosterol metabolic process; early stage flow model biofilm induced; Spider biofilm induced CAALFM_C603250WA Beta-mannosyltransferase; for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; 9-gene family member; regulated by Tsa1, Tsa1B; flow model biofilm induced; rat catheter biofilm repressed CAALFM_C603260WA Putative ribonuclease H1; possibly an essential gene, disruptants not obtained by UAU1 method; flow model biofilm induced; Spider biofilm induced CAALFM_C603270CA Putative NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase; shows colony morphology-related gene regulation by Ssn6p CAALFM_C603280WA Ortholog of C. dubliniensis CD36 : Cd36_63740, C. parapsilosis CDC317 : CPAR2_503850, Pichia stipitis Pignal : PICST_32045 and Candida guilliermondii ATCC 6260 : PGUG_00070 CAALFM_C603290WA Ortholog(s) have methylated histone binding, transcription factor binding activity CAALFM_C603300CA Ortholog(s) have SNARE binding, unfolded protein binding activity CAALFM_C603310WA Protein of unknown function; induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_C603320WA Stationary phase enriched protein; Gcn4-regulated; induced by amino acid starvation (3-AT), benomyl or in azole-resistant strain that overexpresses MDR1; flow model biofilm induced; rat catheter biofilm repressed; overlaps orf19.5621 CAALFM_C603330CA Putative protein of unknown function; mutation confers hypersensitivity to amphotericin B; overlaps orf19.5621 CAALFM_C603340CA Putative 1,4-glucan branching enzyme; fluconazole-induced; colony morphology-related gene regulation by Ssn6; stationary phase enriched protein CAALFM_C603350CA Subunit of the NuA4 histone acetyltransferase complex CAALFM_C603360CA Ortholog of C. dubliniensis CD36 : Cd36_63640, Pichia stipitis Pignal : PICST_32878, Candida guilliermondii ATCC 6260 : PGUG_03423 and Candida tropicalis MYA-3404 : CTRG_02106 CAALFM_C603370WA Protein of unknown function; Plc1-regulated; induced by Mnl1 under weak acid stress; flow model biofilm induced CAALFM_C603380WA S. cerevisiae ortholog Hek2/Khd1 is a putative RNA binding protein involved in the asymmetric localization of ASH1 mRNA; Hap43-induced gene CAALFM_C603390WA Mitochondrial dicarboxylate transporter; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C603400CA Putative ubiquinol-cytochrome-c reductase, subunit 7; Hap43p-repressed gene CAALFM_C603410CA Putative ATP adenylyltransferase II; regulated by Gcn4; repressed by amino acid starvation (3-AT); induced by prostaglandins; Hap43-repressed; Spider biofilm repressed CAALFM_C603420WA Ortholog(s) have role in DNA replication initiation, establishment of mitotic sister chromatid cohesion, mitotic spindle assembly checkpoint and condensed nuclear chromosome kinetochore localization CAALFM_C603430CA Has domain(s) with predicted catalytic activity and role in metabolic process CAALFM_C603440WA Ortholog(s) have rRNA binding activity, role in RNA splicing, mitochondrial RNA processing, mitochondrial genome maintenance, rRNA metabolic process and mitochondrion localization CAALFM_C603450CA Mitochondrial leucyl-tRNA synthetase CAALFM_C603460WA Nucleoporin component of central core of the nuclear pore complex; mRNA binds She3 CAALFM_C603470WA Putative phosphatidylinositol transfer protein; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C603480WA Putative NADH dehydrogenase; macrophage-downregulated gene; induced by nitric oxide; rat catheter biofilm induced CAALFM_C603490CA Secreted aspartyl proteinase; acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase, alpha-pheromone; produced by opaque cells CAALFM_C603500CA Secreted aspartyl proteinase; sap4,5,6 mutant defective in protein utilization for nitrogen; virulence role complicated by URA3 effects; expressed during mucosal and systemic infections; N-glycosylated; rat catheter, Spider biofilm induced CAALFM_C603520CA Has domain(s) with predicted zinc ion binding activity and role in intracellular protein transport, vesicle-mediated transport CAALFM_C603530CA Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 and merged with orf19.1020 based on comparative genome analysis CAALFM_C603540WA Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); ketoconazole or caspofungin repressed; Spider biofilm induced CAALFM_C603550CA Ortholog(s) have DNA binding activity CAALFM_C603560WA Predicted acyl-CoA oxidase; regulated upon white-opaque switch; upregulated upon phagocytosis; Spider biofilm induced CAALFM_C603570WA Ortholog of C. parapsilosis CDC317 : CPAR2_500910, C. dubliniensis CD36 : Cd36_64110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115913 and Pichia stipitis Pignal : PICST_32870 CAALFM_C603580WA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-5-phosphate binding, phosphatidylserine binding activity CAALFM_C603590CA Ortholog of C. dubliniensis CD36 : Cd36_64130, C. parapsilosis CDC317 : CPAR2_601230, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115908 and Debaryomyces hansenii CBS767 : DEHA2E12540g CAALFM_C603600CA Putative cytochrome P450; Spider biofilm induced CAALFM_C603610WA Putative DNA-binding transcription factor; has zinc cluster DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Hap43p-repressed gene CAALFM_C603620CA Putative phenylacrylic acid decarboxylase; clade-associated gene expression CAALFM_C603630WA Putative phenylacrylic acid decarboxylase; repressed by Rgt1p CAALFM_C603640WA Putative nucleolar GTPase; repressed by prostaglandins; Hap43-induced, rat catheter and Spider biofilm induced CAALFM_C603650CA Component of the Ccr4-Pop2 mRNA deadenylase; heterozygous null mutant exhibits resistance to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C603660CA Putative endosomal protein; induced by Mnl1p under weak acid stress CAALFM_C603690WA ALS family adhesin; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis and, at high abundance, ECM-induced aggregation; can form amyloid fibrils CAALFM_C603700WA Cell-surface adhesin; adhesion, virulence, immunoprotective roles; band at hyphal base; Rfg1, Ssk1, Spider biofilm induced; flow model biofilm repressed; CAI-4 strain background effects; promoter bound Bcr1, Tec1, Efg1, Ndt80, and Brg1 CAALFM_C603710WA ALS family cell-surface glycoprotein; expressed during infection of human epithelial cells; confers laminin adhesion to S. cerevisiae; highly variable; putative GPI-anchor; Hap43-repressed CAALFM_C603720WA Alanyl-tRNA synthetase; translational regulation generates cytoplasmic and mitochondrial forms; Gcn4p-regulated; repressed by amino acid starvation (3-AT); translation-related genes downregulated upon phagocytosis by murine macrophages CAALFM_C603730CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C603740WA Ortholog of C. dubliniensis CD36 : Cd36_64250, Candida tenuis NRRL Y-1498 : cten_CGOB_00218, Debaryomyces hansenii CBS767 : DEHA2E19888g and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00025 CAALFM_C603750CA Similar to co-chaperones; induced in high iron; farnesol-, heavy metal (cadmium) stress-induced; protein level decreases in stationary phase cultures; Hap43-repressed CAALFM_C603760CA Cytoplasmic serine hydroxymethyltransferase; complements glycine auxotrophy of S. cerevisiae shm1 shm2 gly1-1 mutant; antigenic; farnesol-upregulated in biofilm; stationary-phase enriched protein; rat catheter and Spider biofilm repressed CAALFM_C603770CA Putative endoplasmic reticulum membrane protein; Hap43p-repressed gene; mutation confers hypersensitivity to aureobasidin A CAALFM_C603780CA Ortholog(s) have ubiquitin-protein transferase activity, role in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and SCF ubiquitin ligase complex localization CAALFM_C603790CA Glycerol permease involved in glycerol uptake; member of the major facilitator superfamily; induced by osmotic stress, at low glucose in rich media, during cell wall regeneration; 12 membrane spans; Hap43p-induced gene CAALFM_C603800CA Putative membrane protein with a predicted role in zinc ion homeostasis; Hap43-induced; fluconazole-induced; rat catheter and Spider biofilm induced CAALFM_C603810WA Ortholog(s) have cyclin-dependent protein serine/threonine kinase regulator activity CAALFM_C603820CA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C603830WA Putative protein phosphatase of the Type 1 family; serine/threonine-specific; similar to S. cerevisiae Ppq1; mutant has virulence defect; Spider biofilm induced CAALFM_C603840CA Protein similar to S. cerevisiae Snq2p transporter; member of PDR subfamily of ABC family; transposon mutation affects filamentation; benomyl-induced transcription; detected at yeast-form cell plasma membrane by mass spec CAALFM_C603850CA GPI-anchored protein; alkaline, hypha-induced; regulated by Nrg1, Rfg1, Tup1 and Tsa1, Tsa1B in minimal media at 37; oralpharyngeal candidasis induced; Spider biofilm induced; regulated in Spider biofilms by Tec1, Efg1, Ndt80, Rob1, Brg1 CAALFM_C603860CA Putative GPI-anchored protein CAALFM_C603880WA Has domain(s) with predicted oxidoreductase activity and role in metabolic process CAALFM_C603890CA Ortholog(s) have role in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay and protein complex assembly, more CAALFM_C603900WA Linker nucleoporin of the nuclear pore complex; role in mRNA andexport from nucleus, protein import into nucleus, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus; rat catheter biofilm repressed CAALFM_C603910CA Ortholog(s) have U2 snRNA binding activity, role in mRNA splicing, via spliceosome and U2 snRNP, U2-type spliceosomal complex localization CAALFM_C603920WA Transcription factor; ortholog of S. cerevisiae Snf4; caspofungin repressed; transposon mutation affects filamentation CAALFM_C603930WA Oligopeptide transporter; similar to Opt1 and to S. cerevisiae Ygl114wp, but not other OPTs; induced by nitric oxide, amphotericin B; expression of OPT6, 7, 8 does not complement mutants lacking Opt1, Opt2, and Opt3; Spider biofilm induced CAALFM_C603940CA Putative RNA binding protein; transcript regulated by Nrg1, Mig1, and Tup1 CAALFM_C603950CA Ortholog(s) have role in histone exchange and Swr1 complex, cytosol localization CAALFM_C603960WA Putative dipeptidyl-peptidase III; protein detected by mass spec in exponential and stationary phase cultures; Hog1p-induced; clade-associated gene expression CAALFM_C603990CA Predicted ORF overlapping the Major Repeat Sequence on chromosome 6; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; rat catheter biofilm repressed CAALFM_C604030WA Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants CAALFM_C604040CA SH3-domain- and BAR domain-containing protein involved in endocytosis; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization; cosediments with phosphorylated Myo5p CAALFM_C604050WA Ortholog of Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_149713 CAALFM_C604060WA Ortholog(s) have ribosomal large subunit binding, ubiquitin-protein transferase activity CAALFM_C604070CA Ortholog of C. dubliniensis CD36 : Cd36_64550, Candida tropicalis MYA-3404 : CTRG_02747 and Candida albicans WO-1 : CAWG_04972 CAALFM_C604080WA Ortholog(s) have metalloaminopeptidase activity, role in protein initiator methionine removal involved in protein maturation and cytosol, nucleus localization CAALFM_C604100WA Ortholog(s) have FFAT motif binding, phosphatidylinositol binding activity CAALFM_C604110WA Ortholog(s) have L-arginine transmembrane transporter activity, L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity, more CAALFM_C604120CA Ortholog(s) have microtubule binding, structural constituent of cytoskeleton activity and role in microtubule nucleation, mitotic spindle assembly checkpoint, protein localization to kinetochore, sister chromatid biorientation CAALFM_C604130CA GPI-anchored adhesin; role in adhesion, germ tube induction; growth, temperature regulated; expressed during infection of human buccal epithelial cells; repressed by vaginal contact; biofilm induced; repressed during chlamydospore formation CAALFM_C604140CA Ortholog of C. dubliniensis CD36 : Cd36_64990, C. parapsilosis CDC317 : CPAR2_600170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_121753 and Debaryomyces hansenii CBS767 : DEHA2E19712g CAALFM_C604150WA Protein of unknown function; Hap43-repressed gene CAALFM_C604160CA Putative AdoMet-dependent methyltransferase; Hap43-induced; repressed by prostaglandins; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C604170CA Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.75 in Assembly 21 CAALFM_C604180WA Putative metalloprotease; associates with ribosomes and is involved in ribosome biogenesis; Spider biofilm induced CAALFM_C604190CA Protein of unknown function; Spider biofilm induced CAALFM_C604210CA Member of MDR subfamily of ABC family; ortholog of S. cerevisiae ABC transporter, Atm1; induced in low iron; induced by nitric oxide independent of Yhb1 CAALFM_C604230WA Ortholog of C. dubliniensis CD36 : Cd36_64900, C. parapsilosis CDC317 : CPAR2_600390, Pichia stipitis Pignal : PICST_30726 and Candida guilliermondii ATCC 6260 : PGUG_04023 CAALFM_C604240WA Protein with an Alba DNA/RNA-binding protein domain; Spider biofilm induced CAALFM_C604250WA Ortholog(s) have cytochrome-c oxidase activity, role in mitochondrial respiratory chain complex IV assembly and cytosol, mitochondrial intermembrane space, mitochondrial respiratory chain complex IV, nucleus localization CAALFM_C604260CA Putative protein of unknown function; macrophage-induced gene CAALFM_C604270WA Protein similar to S. cerevisiae Cdc39p, which is part of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth CAALFM_C604280WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_C604290WA Ortholog(s) have mRNA binding activity and role in protein deubiquitination, regulation of ER to Golgi vesicle-mediated transport, regulation of retrograde vesicle-mediated transport, Golgi to ER, ribophagy CAALFM_C604300WA Ortholog of C. parapsilosis CDC317 : CPAR2_601130, C. dubliniensis CD36 : Cd36_64620, Lodderomyces elongisporus NRLL YB-4239 : LELG_04885 and Candida orthopsilosis Co 90-125 : CORT_0F02130 CAALFM_C604310WA Putative peroxisomal membrane protein; role in fatty acid oxidation; expression is Tac1-regulated; Hms1p-dependent induction by geldamycin; Spider biofilm induced CAALFM_C604320CA Ortholog of C. parapsilosis CDC317 : CPAR2_601110, C. dubliniensis CD36 : Cd36_64660, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119969 and Lodderomyces elongisporus NRLL YB-4239 : LELG_04881 CAALFM_C604330WA Ortholog of S. cereviiae Nop8; has a role in ribosomal large subunit biogenesis; rat catheter and Spider biofilm induced CAALFM_C604340WA Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; role in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; rat catheter biofilm repressed CAALFM_C604350CA Transcription factor; required for hyphal formation and CO2 induced white-opaque switching; regulates hyphal gene expression; required for virulence in mouse systemic infection; binds Efg1p; binds Mss11p via LisH motif; has LUFS domain CAALFM_C604360CA Putative nuclear pore complex; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter biofilm repressed CAALFM_C604370WA Has domain(s) with predicted ion channel activity, voltage-gated chloride channel activity, role in chloride transport, transmembrane transport and membrane localization CAALFM_C604380WA ALS family protein; role in adhesion, biofilm formation, germ tube induction; expressed at infection of human buccal epithelial cells; putative GPI-anchor; induced by ketoconazole, low iron and at cell wall regeneration; regulated by Sfu1p CAALFM_C604400WA Predicted ORF from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis CAALFM_C604410CA Predicted alcohol dehydrogenase; Spider biofilm induced CAALFM_C604420WA Protein of unknown function; GlcNAc-induced protein; Spider biofilm induced; rat catheter biofilm repressed CAALFM_C604430WA Scaffold protein for the mitogen-activated protein (MAP) kinase cascade that regulates mating; required for opaque mating or white biofilm formation in response to mating pheromone; induced in response to pheromone; Hap43p-repressed CAALFM_C604440CA Ortholog of S. cerevisiae Spo71; a meiosis-specific protein required for spore wall formation during sporulation in S. cerevisiae; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C604450WA Ortholog(s) have mitochondrion localization CAALFM_C604470CA Ortholog(s) have ubiquitin-protein transferase activity and role in protein ubiquitination, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway CAALFM_C604480CA Ortholog of C. dubliniensis CD36 : Cd36_65220, C. parapsilosis CDC317 : CPAR2_213740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92162 and Debaryomyces hansenii CBS767 : DEHA2A01056g CAALFM_C604490WA Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; expressed more strongly during mucosal infections than during systemic infections CAALFM_C604500CA Putative transcription initiation factor TFIID subunit; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Nrg1-regulated CAALFM_C604510CA Ortholog(s) have mitochondrion localization CAALFM_C604520WA Putative isoleucyl-tRNA synthetase, the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin; protein present in exponential and stationary growth phase yeast cultures CAALFM_C604530CA Ortholog(s) have role in endocytic recycling and endosome localization CAALFM_C604540CA Putative Hat1-Hat2 histone acetyltransferase complex subunit; role in DNA damage repair and morphogenesis; mutations cause constitutive pseudohyphal growth, caspofungin sensitivity; rat catheter and Spider biofilm repressed CAALFM_C604550CA Putative sulfate permease; S. cerevisiae ortholog YPR003C localizes to the endoplasmic reticulum; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C604560WA Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; Spider biofilm repressed CAALFM_C604570WA Protein required for wild-type mouse virulence and wild-type cycloheximide resistance; putative GTP-binding motif; similar to S. cerevisiae Yor165Wp; in gene cluster that encodes enzymes of GlcNAc catabolism; no human or murine homolog CAALFM_C604580WA N-acetylglucosamine (GlcNAc) kinase; involved in GlcNAc utilization; required for wild-type hyphal growth and mouse virulence; GlcNAc-induced transcript; induced by alpha pheromone in SpiderM medium CAALFM_C604590CA Glucosamine-6-phosphate deaminase; required for normal hyphal growth and mouse virulence; converts glucosamine 6-P to fructose 6-P; reversible reaction in vitro; gene and protein is GlcNAc-induced; Spider biofilm induced CAALFM_C604600WA N-acetylglucosamine-6-phosphate (GlcNAcP) deacetylase; N-acetylglucosamine utilization; required for wild-type hyphal growth and virulence in mouse systemic infection; gene and protein are GlcNAc-induced; Spider biofilm induced CAALFM_C604610CA Putative MFS transporter; similar to Nag4; required for wild-type mouse virulence and cycloheximide resistance; in gene cluster that includes genes encoding enzymes of GlcNAc catabolism; Spider biofilm repressed CAALFM_C604620CA Putative transporter; fungal-specific; similar to Nag3p and to S. cerevisiae Ypr156Cp and Ygr138Cp; required for wild-type mouse virulence and wild-type cycloheximide resistance; gene cluster encodes enzymes of GlcNAc catabolism CAALFM_C604650WA Ortholog(s) have cytosol localization CAALFM_C700010CA Protein of unknown function; Spider biofilm repressed CAALFM_C700020CA Protein required for endocytosis; contains a BAR domain, which is found in proteins involved in membrane curvature; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization CAALFM_C700030WA Protein of unknown function; Spider biofilm repressed CAALFM_C700040CA Protein of unknown function; Spider biofilm repressed CAALFM_C700050CA Ortholog of S. cerevisiae Rad3; 5' to 3' DNA helicase, nucleotide excision repair and transcription, subunit of RNA polII initiation factor TFIIH and Nucleotide Excision Repair Factor 3 (NEF3) CAALFM_C700060CA Ortholog(s) have adenylate kinase activity, nucleoside triphosphate adenylate kinase activity, role in nucleotide metabolic process and mitochondrial inner membrane, mitochondrial matrix localization CAALFM_C700070CA Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressed CAALFM_C700080CA Putative GTPase activating protein (GAP) for Rho1; repressed upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis CAALFM_C700090CA Surface antigen on elongating hyphae and buds; strain variation in repeat number; ciclopirox, filament induced, alkaline induced by Rim101; Efg1-, Cph1, Hap43-regulated; required for WT RPMI biofilm formation; Bcr1-induced in a/a biofilms CAALFM_C700100WA Putative ferric reductase; alkaline induced by Rim101; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced; regulated by Sef1, Sfu1, and Hap43 CAALFM_C700110WA Cytosolic manganese-containing superoxide dismutase; protects against oxidative stress; repressed by ciclopirox olamine, induced during stationary phase when SOD1 expression is low; Hap43-repressed; Spider and flow model biofilm induced CAALFM_C700120WA Putative mitochondrial outer membrane protein membrane fission effector; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C700130WA Ortholog(s) have tRNA-specific adenosine-37 deaminase activity, role in tRNA modification and cytosol, nucleus localization CAALFM_C700140CA Ortholog(s) have cytosol, nucleus localization CAALFM_C700150WA D-ribulose-5-phosphate 3-epimerase; stationary phase enriched protein CAALFM_C700160CA Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, nucleus, ribosome localization CAALFM_C700170WA Ortholog(s) have role in protein targeting to vacuole and endoplasmic reticulum localization CAALFM_C700180WA Protein involved in regulation of pheromone-mediated mating; repressed by A1p and Alpha2p in white-phase cells; null mutant shows no pheromone response in opaque cells; overexpression causes enhanced pheromone response and cell cycle arrest CAALFM_C700190WA Adhesin-like cell wall protein; similar to mucins and to a Litomosoides microfilarial sheath protein; N-terminal secretion signal; rat catheter and Spider biofilm repressed CAALFM_C700200WA Predicted exonuclease; Spider biofilm induced CAALFM_C700210CA Ortholog(s) have telomeric DNA binding activity, role in protein localization to chromosome, telomere maintenance via telomerase and ASTRA complex, nuclear chromosome, telomeric region localization CAALFM_C700220WA Has domain(s) with predicted exonuclease activity and intracellular localization CAALFM_C700230WA Putative vacuolar transporter of large neutral amino acids; possibly transcriptionally regulated upon hyphal formation; not the true Avt1 ortholog of S. cerevisiae CAALFM_C700240WA Putative protein of unknown function; Hap43-repressed; repressed by nitric oxide; Spider biofilm induced CAALFM_C700250CA Putative cytoplasmic RNA-binding protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in C. albicans fitness test; Spider biofilm repressed CAALFM_C700260CA Ortholog(s) have fungal-type vacuole membrane, mitochondrion localization CAALFM_C700270WA Ortholog(s) have fluoride transmembrane transporter activity, role in fluoride transmembrane transport and endoplasmic reticulum, plasma membrane localization CAALFM_C700280WA Glucose, fructose, mannose transporter; major facilitator superfamily; role in macrophage-induced hyphal growth; detected at germ tube plasma membrane by mass spectrometry; Snf3p-induced; 12 probable transmembrane segments CAALFM_C700290CA Predicted sugar transporter, involved in glycerol utilization; member of the major facilitator superfamily; 12 transmembrane; gene has intron; oxidative stress-induced via Cap1p; expressed in rich medium, 2% glucose CAALFM_C700300WA Putative NAD dependent epimerase/dehydratase family protein; Spider biofilm repressed CAALFM_C700310CA Protein of unknown function; induced by nitric oxide; Spider biofilm repressed CAALFM_C700320CA Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1 CAALFM_C700330CA Ortholog(s) have single-stranded telomeric DNA binding activity, role in regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification, telomere maintenance and cytosol, nucleus localization CAALFM_C700340CA Ortholog(s) have protein transporter activity, role in transcription factor import into nucleus and cytosol, nuclear envelope localization CAALFM_C700350CA Protein of unknown function; induced in core stress response; induced by cadmium stress via Hog1; oxidative stress-induced via Cap1; induced by Mnl1 under weak acid stress; macrophage-repressed; rat catheter and Spider biofilm induced CAALFM_C700360WA Cell-surface associated glycoprotein; promotes activation of Cek1 in a matrix-dependent manner; N-glycosylated; Spider biofilm induced CAALFM_C700370WA Protein with a predicted role in sister chromatid cohesion and telomere length maintenance; cell-cycle regulated periodic mRNA expression CAALFM_C700380WA S-adenosylmethionine transporter of the mitochondrial inner membrane; mitochondrial carrier family; predicted role in biotin biosynthesis and respiratory growth; Spider biofilm repressed CAALFM_C700390WA Protein similar to S. cerevisiae Spl1p, which is involved in tRNA splicing; member of pyridoxal-phosphate-dependent aminotransferase protein family; predicted to be essential CAALFM_C700400WA Isopropyl malate dehydrogenase; leucine biosynthesis; induced by human whole blood or PMNs; protein level decreases in stationary phase; GlcNAc-induced protein; flow model biofilm repressed CAALFM_C700410CA Ortholog(s) have Rho guanyl-nucleotide exchange factor activity, role in axial cellular bud site selection, cytogamy, positive regulation of GTPase activity and cellular bud neck contractile ring localization CAALFM_C700420CA Ortholog(s) have cytoplasm localization CAALFM_C700430WA Putative ferric reductase; induced by Mac1 under copper starvation; Plc1-regulated; Rim101-repressed CAALFM_C700440CA Putative single-strand telomeric DNA-binding protein; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C700450CA Ortholog(s) have methylated histone binding, transcription factor activity, RNA polymerase II transcription factor recruiting activity CAALFM_C700460WA Ortholog of S. cerevisiae : YCL002C, C. glabrata CBS138 : CAGL0B04719g, C. dubliniensis CD36 : Cd36_70180, C. parapsilosis CDC317 : CPAR2_805360 and Candida tenuis NRRL Y-1498 : cten_CGOB_00114 CAALFM_C700470CA Predicted enzyme of mitochondrial phospholipid biosynthesis; rat catheter and flow model biofilm induced CAALFM_C700480WA Protein similar to phosphate transporters; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching CAALFM_C700490CA Putative AdoMet-dependent proline methyltransferase; Hap43-induced; required for normal flow model biofilm growth; Spider biofilm repressed CAALFM_C700500WA Ortholog of Candida guilliermondii ATCC 6260 : PGUG_03499, Candida lusitaniae ATCC 42720 : CLUG_00410 and Candida albicans WO-1 : CAWG_05407 CAALFM_C700510WA Copper fist transcription factor; regulator of CTR1 copper transporter; induces CTR1 in low-copper conditions; required for copper regulation of SOD1 and SOD3; Spider biofilm induced CAALFM_C700520WA Ortholog(s) have RNA polymerase II C-terminal domain phosphoserine binding, RNA polymerase II core binding, transcription factor activity, RNA polymerase II transcription factor binding, triplex DNA binding activity CAALFM_C700530CA Putative GINS complex subunit; cell-cycle regulated periodic mRNA expression; Spider biofilm induced CAALFM_C700550CA Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures CAALFM_C700560CA tRNA guanylyltransferase, with role in tRNA modification; catalyzes reverse (3'-5') nucleotide polymerization CAALFM_C700570WA Putative RNA polymerase I subunit A135; repressed by prostaglandins CAALFM_C700580CA Ortholog(s) have ATPase activity and cytosol, nucleus localization CAALFM_C700590WA Ortholog of C. dubliniensis CD36 : Cd36_70070, C. parapsilosis CDC317 : CPAR2_301080, Debaryomyces hansenii CBS767 : DEHA2F22946g and Pichia stipitis Pignal : PICST_46820 CAALFM_C700600CA Ortholog(s) have endoribonuclease activity, role in nuclear mRNA surveillance of mRNP export, transcription, DNA-templated and cytoplasm, nucleus localization CAALFM_C700610CA Ortholog(s) have cytoplasm, nucleus localization CAALFM_C700620WA Putative glutamine-tRNA ligase; stationary phase enriched protein; Spider biofilm repressed CAALFM_C700630CA Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Sef1, Sfu1, and Hap43 CAALFM_C700660WA Putative regulatory subunit of ser/thr phosphoprotein phosphatase 1; fluconazole-induced; caspofungin repressed; transcript induced by Mnl1 under weak acid stress; regulated by Nrg1, Tup1; Spider and flow model biofilm induced CAALFM_C700670CA Putative polyphosphatidylinositol phosphatase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C700680WA Maf-like protein; rat catheter biofilm induced CAALFM_C700690WA Nucleolar ribosome biogenesis factor; hyphal-induced expression; Hap43-induced; rat catheter biofilm induced CAALFM_C700700WA Cytochrome b(5); ortholog of S. cerevisiae Cyb5; induced in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6; mutants are viable CAALFM_C700710WA Putative ribosomal protein S28B CAALFM_C700720WA Putative RNA polymerase II-associated Paf1 complex subunit; induced during the mating process CAALFM_C700730WA Predicted bZIP domain-containing transcription factor; protein induced during the mating process; possibly essential, disruptants not obtained by UAU1 method; Hap43-repressed; rat catheter biofilm induced CAALFM_C700740WA Ortholog(s) have protein kinase activity CAALFM_C700750WA Protein similar to a region of acyl-coenzyme-A-binding protein; amphotericin B repressed; regulated by Nrg1, Tup1; Hap43-induced CAALFM_C700760CA Ortholog(s) have endoplasmic reticulum localization CAALFM_C700770WA Protein of unknown function; induced by benomyl or in an azole-resistant strain overexpressing MDR1; induced by nitric oxide; Spider biofilm induced CAALFM_C700780WA Putative pre-tRNA processing protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test CAALFM_C700790WA Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in membrane tubulation, protein targeting to vacuole, retrograde transport, endosome to Golgi and endosome, nucleus localization CAALFM_C700800CA Ortholog(s) have role in ribosomal large subunit biogenesis, translational initiation and cytoplasm, nucleus localization CAALFM_C700810WA Ortholog(s) have phosphatase activator activity, role in actin filament organization, endocytosis, mitophagy, regulation of growth, response to heat, response to salt stress and cytosol, nucleus localization CAALFM_C700820WA Putative heteropentameric replication factor C subunit; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_C700830CA Putative eIF4E-associated protein;, accelerates mRNA degradation by promoting decapping; Spider biofilm repressed CAALFM_C700840CA Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p CAALFM_C700850WA Ortholog of C. dubliniensis CD36 : Cd36_70790, C. parapsilosis CDC317 : CPAR2_301530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94947 and Debaryomyces hansenii CBS767 : DEHA2A05258g CAALFM_C700860WA Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red CAALFM_C700870WA Putative guanine deaminase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced CAALFM_C700880CA Protein of unknown function; Spider biofilm induced CAALFM_C700890CA Transcription factor; regulator of hyphal growth; may act with Wor1p; canonical and non-canonical binding sites; MADS domain DNA-binding motif; similar to S. cerevisiae Mcm1p; greater expression in white than opaque cells; intron in 5'-UTR CAALFM_C700910CA Ortholog of S. cerevisiae Ioc4, a protein that influences gene expression through chromatin remodeling; oxidative stress-induced via Cap1 CAALFM_C700920CA Ortholog of C. dubliniensis CD36 : Cd36_70850, Candida tenuis NRRL Y-1498 : cten_CGOB_00183, Debaryomyces hansenii CBS767 : DEHA2F22462g and Pichia stipitis Pignal : PICST_60416 CAALFM_C700930WA Putative glycogen phosphorylase; role in glycogen metabolism; regulated by Ssk1, Mig1, Tup1, Hap43; fluconazole-induced; localizes to cell surface of hyphae, not yeast; stationary phase enriched protein; Spider biofilm induced CAALFM_C700940WA Protein similar to S. cerevisiae Kex1p, which is a pheromone-processing peptidase; possible Kex2p substrate CAALFM_C700950WA Putative mitochondrial ribosomal protein; induced upon adherence to polystyrene CAALFM_C700960WA Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; repressed by nitric oxide; Hap43-induced; Spider biofilm repressed CAALFM_C700970CA Putative homeodomain-containing transcription factor; transcriptional repressor; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_C700980WA Ortholog(s) have endopolyphosphatase activity, exopolyphosphatase activity, role in polyphosphate catabolic process and cytosol, fungal-type vacuole membrane, nucleus localization CAALFM_C700990WA Putative ribosomal protein; antigenic in mouse; repressed upon phagocytosis by murine macrophage; induced by Tbf1; overlaps orf19.7014; Spider biofilm repressed CAALFM_C701000CA Putative protein of unknown function; transcription is positively regulated by Tbf1p; overlaps orf19.7015 CAALFM_C701010WA Ortholog of C. dubliniensis CD36 : Cd36_70940, C. parapsilosis CDC317 : CPAR2_300280, Debaryomyces hansenii CBS767 : DEHA2F22220g and Pichia stipitis Pignal : PICST_32459 CAALFM_C701020CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_C701030CA Ortholog(s) have mRNA binding activity and 90S preribosome, cytoplasm, mitotic spindle pole body, nucleolus localization CAALFM_C701040CA Ortholog(s) have cytosol, ubiquitin ligase complex localization CAALFM_C701050WA Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process CAALFM_C701060WA Ortholog of C. dubliniensis CD36 : Cd36_70990 and Candida albicans WO-1 : CAWG_05464 CAALFM_C701070CA Ortholog(s) have role in reciprocal meiotic recombination CAALFM_C701100CA Predicted ORF overlapping the Major Repeat Sequence on chromosome 7; member of a family encoded by FGR6-related genes in the RB2 repeat sequence CAALFM_C701130CA Protein of unknown function CAALFM_C701150WA Protein similar to S. pombe SPBC1709.16c a predicted aromatic ring-opening dioxygenase; induced by benomyl treatment or in azole-resistant strain that overexpresses MDR1; Spider biofilm induced CAALFM_C701160CA Ortholog(s) have mitochondrion localization CAALFM_C701170CA Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; rat catheter and Spider biofilm induced CAALFM_C701180WA Ortholog(s) have role in establishment or maintenance of cell polarity, mitochondrial outer membrane translocase complex assembly, mitochondrion inheritance, mitochondrion-ER tethering, phospholipid transport CAALFM_C701190WA Ortholog(s) have RNA 7-methylguanosine cap binding, exoribonuclease activator activity, m7G(5')pppN diphosphatase activity CAALFM_C701200CA Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; rat catheter biofilm induced CAALFM_C701210CA Predicted RNA polymerase III subunit C37; Spider biofilm induced CAALFM_C701220WA Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells CAALFM_C701230CA Ortholog of S. cerevisiae : YNL011C, C. glabrata CBS138 : CAGL0H03619g, C. dubliniensis CD36 : Cd36_71090, C. parapsilosis CDC317 : CPAR2_300420 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_111980 CAALFM_C701250WA 40S ribosomal subunit similar to G-beta subunits; glucose or N starvation induced filamentation; required for virulence in mice; snoRNA snR24 encoded in ASC1 intron; repressed in stationary phase; GlcNAc-induced; Spider biofilm repressed CAALFM_C701270CA Ortholog(s) have DNA binding activity, role in regulation of DNA damage checkpoint and cytoplasm, nuclear chromatin, nuclear periphery localization CAALFM_C701280CA Dihydrofolate synthetase involved in folic acid biosynthesis CAALFM_C701290WA Subunit of the RNA polymerase II mediator complex CAALFM_C701300CA Putative GINS complex subunit which is localized to DNA replication origins; implicated in assembly of the DNA replication machinery; flow model biofilm induced CAALFM_C701320WA Putative ethanolamine kinase CAALFM_C701330CA Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p CAALFM_C701340WA Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance CAALFM_C701350CA Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization CAALFM_C701360CA Putative heat shock protein with a zinc finger motif; required for protein import into mitochondria in S. cerevisiae; Spider biofilm induced CAALFM_C701370WA Protein of unknown function; Hap43-induced gene; Spider biofilm induced CAALFM_C701380WA Ortholog of C. dubliniensis CD36 : Cd36_71210, C. parapsilosis CDC317 : CPAR2_702710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116256 and Debaryomyces hansenii CBS767 : DEHA2E17732g CAALFM_C701390WA Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced CAALFM_C701400CA Ortholog(s) have transcription factor activity, RNA polymerase I upstream control element sequence-specific binding activity and role in chromatin organization, transcription of nuclear large rRNA transcript from RNA polymerase I promoter CAALFM_C701410CA Protein containing an SH3 domain; involved in vacuolar fusion in hyphae; mutants form multiple germ tubes; Spider biofilm induced CAALFM_C701420WA Ortholog of S. cerevisiae Gir2; transposon mutation affects filamentous growth CAALFM_C701430CA Protein of unknown function; transcript induced by benomyl or in azole-resistant strain overexpressing MDR1; Ssn6 colony morphology-related regulation; induced by NO; Hap43-repressed; rat catheter and flow model biofilm induced CAALFM_C701440WA Ortholog(s) have mitochondrion localization CAALFM_C701450CA Putative translation initiation factor eIF3; mutation confers hypersensitivity to roridin A, verrucarin A; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages CAALFM_C701460CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_C701470CA Alpha7 (C8) subunit of the 20S proteasome; multiple phosphorylated residues; transcript induced upon filamentous growth; Spider biofilm repressed CAALFM_C701480WA Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation and endoplasmic reticulum localization CAALFM_C701490WA Protein of unknown function; Spider biofilm induced CAALFM_C701500WA Ortholog of C. dubliniensis CD36 : Cd36_71340, C. parapsilosis CDC317 : CPAR2_301350, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114098 and Debaryomyces hansenii CBS767 : DEHA2D03432g CAALFM_C701510WA Predicted membrane transporter; vesicular neurotransmitter (VNT) family, major facilitator superfamily (MFS); repressed in core caspofungin response; induced in oralpharyngeal candidasis; Spider biofilm induced CAALFM_C701520WA Multidrug efflux pump of the plasma membrane; MDR family member of the MFS (major facilitator superfamily) of transporters; involved in histatin 5 efflux; fungal-specific (no human/murine homolog) CAALFM_C701540WA Putative cytochrome P-450 of N-alkane-induced detoxification; macrophage-induced gene CAALFM_C701550WA Putative Rho1p GTPase activating protein (GAP); serum-induced transcript; Spider biofilm induced; flow model biofilm repressed CAALFM_C701560CA Nucleoside permease; adenosine and guanosine are substrates, whereas cytidine, adenine, guanine, uridine, uracil are not; similar to a nucleoside permease of S. pombe; possibly processed by Kex2p CAALFM_C701570CA Predicted transmembrane transporter; induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_C701580WA Putative structural maintenance of chromosomes (SMC) protein; Hap43-induced; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog not cell-cycle regulated; Spider biofilm induced CAALFM_C701590CA Ortholog of C. dubliniensis CD36 : Cd36_71420, C. parapsilosis CDC317 : CPAR2_300980, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94952 and Debaryomyces hansenii CBS767 : DEHA2A05346g CAALFM_C701600WA Conserved mitochondrial inner membrane insertase; mediates insertion of mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; Spider biofilm repressed CAALFM_C701610WA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly, negative regulation of mitochondrial translation and integral component of mitochondrial inner membrane localization CAALFM_C701620CA Ortholog of Kch1 a potassium transporter; mediates K+ influx and activates high-affinity Ca2+ influx system during mating pheromone response in S. cerevisiae; induced by alpha pheromone in SpiderM medium CAALFM_C701630WA Putative ribonuclease H2 catalytic subunit; flucytosine induced; Spider biofilm repressed CAALFM_C701640WA Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex; sumoylation target; Spider biofilm repressed CAALFM_C701650WA RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; growth phase regulated protein; downregulaated in stationary phase yeast cultures; Hap43-repressed; flow model biofilm induced; Spider biofilm repressed CAALFM_C701660CA Ortholog(s) have GTPase activator activity and cytosol localization CAALFM_C701670WA Protein with a predicted fatty acid amide hydrolase I domain; induced by Mnl1 under weak acid stress CAALFM_C701680CA Protein of unknown function; rat catheter, flow model and Spider biofilm induced CAALFM_C701690WA Ortholog(s) have zinc ion binding activity, role in protein import into mitochondrial intermembrane space and cytosol, mitochondrial intermembrane space, nucleus localization CAALFM_C701700WA Regulator of calcineurin; regulated by calcineurin-Crz1 pathway; feedback regulator of calcineurin-dependent signaling; Hap43-repressed; induced by ketoconazole, hypoxia, during growth in the mouse cecum; Spider biofilm induced CAALFM_C701710WA Membrane-localized protein of unknown function; possibly secreted; fluconazole-induced CAALFM_C701720WA Flavin-linked sulfhydryl oxidase; predicted localization to endoplasmic reticulum lumen; involved in disulfide bond formation within the ER; Spider biofilm induced CAALFM_C701730CA Protein similar to S. cerevisiae Ste18p; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; MTLa1p, MTLalpha2p bind promoter region CAALFM_C701740CA Ortholog(s) have SNAP receptor activity, role in Golgi vesicle transport, vesicle fusion and Golgi medial cisterna, SNARE complex localization CAALFM_C701750WA Putative mitochondrial outer membrane protein; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_C701760CA Protein with similarity to NifU; possible role in iron-sulfur cluster biogenesis; induced in low iron; rat catheter biofilm induced; rat catheter and Spider biofilm induced CAALFM_C701780WA Protein phosphatase type 1 regulator; role in chromosome segregation, regulation of phosphoprotein phosphatase activity; rat catheter and Spider biofilm induced CAALFM_C701790CA Ribosomal protein; repressed upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed CAALFM_C701800CA Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed CAALFM_C701810WA Putative trancription modulator; RuvB-like protein family member; heterozygous null mutant displays sensitivity to virgineone CAALFM_C701820CA Predicted ortholog of S. cerevisiae Tfp3/Vma11; c' subunit of the V0 subcomplex of the vacuolar ATPase; required for hemoglobin-iron utilization; Spider biofilm repressed CAALFM_C701830WA Ortholog(s) have role in chromosome segregation and nuclear MIS12/MIND complex, spindle pole localization CAALFM_C701840WA Actomyosin ring component at bud neck; cell-cycle regulated ser phosphorylation at CDK sites regulate association with Bni1/Bnr1, Iqg1 degradation, and ring disassembly; mutation causes cytokinetic defects; rat catheter biofilm repressed CAALFM_C701850CA Coronin; cortical actin cytoskeletal component; predicted role in regulation of actin patch assembly; rat catheter and Spider biofilm repressed CAALFM_C701870WA Putative mitochondrial lysine-tRNA synthetase; flucytosine repressed CAALFM_C701880CA Ortholog(s) have FAD transmembrane transporter activity, role in FAD transport and mitochondrion localization CAALFM_C701890CA Predicted component of the TOM (translocase of outer membrane) complex involved in protein translocation into mitochondria; flucytosine induced CAALFM_C701900WA Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); alkaline repressed; Hap43-repressed; Spider biofilm repressed CAALFM_C701910CA Similar to bacterial DnaJ; transcript upregulated in low iron; flow model biofilm induced; Spider biofilm induced CAALFM_C701920WA Putative ubiquitin-protein ligase; transcript regulated by Nrg1 and Tup1, and by Gcn2 and Gcn4; rat catheter biofilm induced CAALFM_C701930CA Ortholog of C. dubliniensis CD36 : Cd36_71740, C. parapsilosis CDC317 : CPAR2_703440, Candida tenuis NRRL Y-1498 : CANTEDRAFT_102923 and Debaryomyces hansenii CBS767 : DEHA2C03190g CAALFM_C701940CA Pheromone-regulated protein (Prm10) of S. cerevisiae; colony morphology-related gene regulation by Ssn6; induced by Mnl1 under weak acid stress; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C701950WA Ortholog(s) have COPI-coated vesicle, Golgi apparatus, nuclear periphery localization CAALFM_C701960WA S. cerevisiae ortholog Inp1 is a peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; induced by Mnl1 under weak acid stress CAALFM_C701970CA Protein involved in mitochondrial protein import; Spider biofilm repressed CAALFM_C701990CA Putative allantoate permease; Gcn4-regulated; Spider biofilm induced CAALFM_C702000CA Putative allantoate permease; fungal-specific (no human or murine homolog) CAALFM_C702010CA Predicted aldehyde dehydrogenase [NAD(P)+]; Spider biofilm induced CAALFM_C702020WA Putative DNA repair protein; transcription is regulated upon yeast-hyphal switch; flucytosine repressed CAALFM_C702030WA Essential chaperone, regulates several signal transduction pathways and temperature-induced morphogenesis; activated by heat shock, stress; localizes to surface of hyphae, not yeast cells; mediates echinocandin and biofilm azole resistance CAALFM_C702040CA Transcription factor; represses SOK1 expression in response to farnesol inhibition; yeast-hypha switch repressed; ketoconazole-induced; Plc1-regulated; colony morphology-related Ssn6 regulation; Spider, flow model biofilm induced CAALFM_C702050CA Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip CAALFM_C702060WA tRNA ligase; functional homolog of S. cerevisiae Trl1 CAALFM_C702070WA Putative glutaredoxin; induced in low iron CAALFM_C702080WA Ortholog(s) have glutathione disulfide oxidoreductase activity and cytosol, nucleus localization CAALFM_C702090CA Ortholog(s) have GTPase activator activity, role in positive regulation of GTPase activity, positive regulation of TORC1 signaling and Lst4-Lst7 complex, cytosol, nucleus, vacuolar membrane localization CAALFM_C702100WA Putative curved DNA-binding protein orthologous to S. pombe Cdb4; stationary phase enriched protein; rat catheter and Spider biofilm repressed CAALFM_C702110WA Ortholog(s) have role in histone deacetylation, negative regulation of antisense RNA transcription and positive regulation of transcription from RNA polymerase II promoter, more CAALFM_C702120CA Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translation and mitochondrial large ribosomal subunit localization CAALFM_C702130WA Short-chain dehydrogenase/reductase; upregulation correlates with clinical development of fluconazole resistance CAALFM_C702140WA Ortholog of C. dubliniensis CD36 : Cd36_71960, Pichia stipitis Pignal : psti_CGOB_00136, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_63786 and Candida tropicalis MYA-3404 : CTRG_05049 CAALFM_C702150CA Ornithine acetyltransferase; Gcn2, Gcn4-regulated; clade-specific gene expression; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_C702160WA Predicted DNA-directed RNA polymerase; role in transcription; Spider biofilm induced CAALFM_C702170CA Ortholog(s) have role in RNA polymerase II complex import to nucleus, RNA polymerase III complex localization to nucleus and DNA-directed RNA polymerase II, holoenzyme, cytoplasm localization CAALFM_C702180CA Putative TRAPP complex subunit; constitutive expression independent of MTL or white-opaque status CAALFM_C702200WA Putative RNA binding protein; induced during infection of murine kidney, compared to growth in vitro; has murine homolog CAALFM_C702210WA Ortholog of C. dubliniensis CD36 : Cd36_72020 and Candida albicans WO-1 : CAWG_05570 CAALFM_C702220CA Predicted protein serine/threonine kinase and/or protein tyrosine kinase; Spider biofilm induced CAALFM_C702240WA Predicted membrane protein induced during mating; mutation confers hypersensitivity to toxic ergosterol analog, to amphotericin B; alkaline repressed; repressed by alpha pheromone in SpiderM medium; rat catheter, Spider biofilm induced CAALFM_C702250WA Ortholog of C. dubliniensis CD36 : Cd36_72050, C. parapsilosis CDC317 : CPAR2_301140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135055 and Debaryomyces hansenii CBS767 : DEHA2E07678g CAALFM_C702260WA Ortholog of C. parapsilosis CDC317 : CPAR2_808350, C. dubliniensis CD36 : Cd36_72060, Candida orthopsilosis Co 90-125 : CORT_0C00820 and Candida albicans WO-1 : CAWG_05575 CAALFM_C702270WA Putative LDG family protein; F-12/CO2 early biofilm induced CAALFM_C702280WA Ortholog of C. parapsilosis CDC317 : CPAR2_808370, C. dubliniensis CD36 : Cd36_72070, Candida orthopsilosis Co 90-125 : CORT_0C00800 and Candida albicans WO-1 : CAWG_05577 CAALFM_C702290WA Protein of unknown function; induced by nitric oxide independent of Yhb1p; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm induced CAALFM_C702300WA Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone CAALFM_C702310CA Ortholog(s) have role in UDP-glucose transport and COPI-coated vesicle, Golgi apparatus localization CAALFM_C702320WA Ortholog(s) have SNARE binding activity and role in positive regulation of vesicle fusion, vesicle docking involved in exocytosis CAALFM_C702330WA Putative glutathione S-conjugate transporter; MRP/CFTR-subfamily, ABC type transporter; human neutrophil-induced; oxidative stress-induced via Cap1; possible association with multidrug resistance; possibly essential; Spider biofilm induced CAALFM_C702340CA Ortholog(s) have tRNA (guanine-N7-)-methyltransferase activity, role in tRNA methylation and cytosol, nucleus, tRNA methyltransferase complex localization CAALFM_C702350CA Putative protein with a predicted role in exocytic transport from the Golgi; filament induced CAALFM_C702360WA Protein of unknown function; flow model biofilm induced CAALFM_C702370WA Protein with chitin synthesis regulation, resistance to Congo red domain; membrane-localized protein; Spider biofilm induced CAALFM_C702380CA Peptidyl-prolyl cis-trans isomerase; cyclosporin A sensitive activity; soluble in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol; present in exponential and stationary phase cells CAALFM_C702390WA Putative thiol-specific peroxiredoxin; macrophage-downregulated gene CAALFM_C702420CA Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase CAALFM_C702430CA Ortholog of C. dubliniensis CD36 : Cd36_83910, Candida tropicalis MYA-3404 : CTRG_05087 and Candida albicans WO-1 : CAWG_00654 CAALFM_C702450WA Protein of unknown function; induced upon adherence to polystyrene; oxidative stress-induced via Cap1 CAALFM_C702460CA Putative ortholog of S. cerevisiae Npa3p; possibly essential for growth (however, depletion mutant is viable) CAALFM_C702470CA Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex, cytosol localization CAALFM_C702480WA Ortholog(s) have unfolded protein binding activity, role in aerobic respiration, mitochondrial respiratory chain complex IV assembly, protein processing and mitochondrial inner membrane localization CAALFM_C702490WA Ortholog(s) have ATPase activity, protein heterodimerization activity, role in fatty acid metabolic process, protein import into peroxisome matrix, receptor recycling and peroxisomal membrane localization CAALFM_C702500CA Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1; required for farnesol biosynthesis; repressed by 17-beta-estradiol, ethynyl estradiol; Spider biofilm induced CAALFM_C702510WA Ortholog(s) have U6 snRNA binding activity and role in cytoplasmic mRNA processing body assembly, mRNA splicing, via spliceosome CAALFM_C702520WA Ortholog of C. dubliniensis CD36 : Cd36_72260, C. parapsilosis CDC317 : CPAR2_702840, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115664 and Debaryomyces hansenii CBS767 : DEHA2B05940g CAALFM_C702530CA Ortholog of S. cerevisiae : YBL086C, C. glabrata CBS138 : CAGL0C01815g, C. dubliniensis CD36 : Cd36_72270, C. parapsilosis CDC317 : CPAR2_702850 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_107537 CAALFM_C702540WA Ortholog of C. dubliniensis CD36 : Cd36_72280, C. parapsilosis CDC317 : CPAR2_703040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_125842 and Debaryomyces hansenii CBS767 : DEHA2B05984g CAALFM_C702550CA Protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis CAALFM_C702560WA Ortholog of C. dubliniensis CD36 : Cd36_72300, C. parapsilosis CDC317 : CPAR2_703060, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92002 and Debaryomyces hansenii CBS767 : DEHA2B06028g CAALFM_C702570CA Peptidyl-prolyl cis-trans isomerase; rapamycin-binding protein; homozygous null mutation confers rapamycin resistance; regulated by Gcn4p; macrophage-induced protein; repressed in response to 3-AT; functional homolog of S. cerevisiae Rbp1p CAALFM_C702600CA Pol protein of retrotransposon Tca2; separated by a stop codon from Gag protein orf19.2371; likely translated as single polyprotein with Gag, reverse transcriptase, protease, and integrase; rat catheter biofilm repressed CAALFM_C702610CA Putative Gag protein of retrotransposon Tca2; separated by a stop codon from Pol protein orf19.2372; likely translated as single polyprotein that includes Gag, reverse transcriptase, protease, and integrase; rat catheter biofilm repressed CAALFM_C702630WA Protein of unknown function; mutants are viable; ortholog of S. cervisiae Art10, a protein of unknown function CAALFM_C702640WA Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in protein import into mitochondrial inner membrane, protein import into mitochondrial matrix CAALFM_C702650WA Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Tep1p CAALFM_C702660CA Protein of unknown function that may function in RNA processing; filament induced CAALFM_C702670WA Ortholog(s) have role in ascospore formation, intra-S DNA damage checkpoint, positive regulation of macroautophagy, re-entry into mitotic cell cycle after pheromone arrest and regulation of meiosis I, more CAALFM_C702680WA Putative mitochondrial import receptor subunit; colony morphology-related gene regulation by Ssn6 CAALFM_C702690CA Ortholog(s) have diacylglycerol cholinephosphotransferase activity, ethanolaminephosphotransferase activity, role in phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process and Golgi apparatus localization CAALFM_C702770WA Chitin synthase; essential; for primary septum synthesis in yeast and hyphae; 1 of several chitin synthases; enzymatically activated by proteolytic processing; complements defects of S. cerevisiae chs1 or chs2; Spider biofilm repressed CAALFM_C702780WA Putative Ran guanyl-nucleotide exchange factor; probable signal transducer; Spider biofilm repressed CAALFM_C702790CA Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle; Hap43p-repressed CAALFM_C702800WA Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; required for wild-type virulence in mouse systemic infection but not for wild-type growth or drug sensitivity/resistance; 9 HAMP domains CAALFM_C702810WA Thioredoxin peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed; protein present in exponential and stationary growth phase yeast cultures CAALFM_C702830CA Cold-activated secreted lipase, differentially expressed lipase gene family member with possible roles in nutrition and acidic microenvironment; LIP5 and LIP8 expressed at all stages of mucosal and systemic infection; affects filamentation CAALFM_C702840CA Putative C-22 sterol desaturase; fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth CAALFM_C702850WA Ortholog of Candida albicans WO-1 : CAWG_05627 CAALFM_C702860CA Ortholog(s) have ubiquitin protein ligase activity and role in ER-associated ubiquitin-dependent protein catabolic process CAALFM_C702870CA Putative TFIID subunit; mutation confers hypersensitivity to amphotericin B; rat catheter biofilm induced CAALFM_C702880CA Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment CAALFM_C702890CA Protein mannosyltransferase; required for virulence in mice and for adhesion to epithelial cells; role in hyphal growth and drug sensitivity; Als1, Sec20, Kre9, Pir1 are substrates; 1 of 5 PMT family members CAALFM_C702910WA Predicted P-type ATPase sodium pump; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame; Spider biofilm induced CAALFM_C702920WA Has domain(s) with predicted carbon-nitrogen ligase activity, with glutamine as amido-N-donor activity CAALFM_C702930CA Ortholog(s) have role in maturation of SSU-rRNA and cytosol, nucleolus localization CAALFM_C702940CA Putative mitochondrial translation initiation factor; transcript regulated by Nrg1, Mig1, and Tup1 CAALFM_C702950CA Putative Cdc7p-Dbf4p kinase complex regulatory subunit; Hap43p-induced gene; macrophage/pseudohyphal-repressed; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated CAALFM_C702960CA Ortholog(s) have cytoplasm localization CAALFM_C702970WA Putative mannosyltransferase similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance; predicted Kex2p substrate; has HKEXRF motif CAALFM_C702980CA Putative centrin-binding protein; predicted role in spindle pole body duplication; induced by alpha pheromone in SpiderM medium; essential for growth CAALFM_C702990WA Ortholog of S. cerevisiae Bck1; MAP kinase kinase kinase of cell integrity pathway; mutant is hypersensitive to caspofungin CAALFM_C703000CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_C703010WA Ortholog(s) have role in G1/S transition of mitotic cell cycle, TOR signaling, dephosphorylation, regulation of mitotic sister chromatid segregation, tRNA wobble uridine modification CAALFM_C703020CA Putative glutamine amidotransferase (GATase II); role in glutathione catabolism CAALFM_C703030WA Protein with similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4, Cyr1; induced by amino acid starvation; macrophage-induced protein, macrophage-repressed; Spider biofilm induced CAALFM_C703040WA Protein with a protein tyrosine phosphatase-like protein domain; putative membrane-spanning regions; rat catheter biofilm induced CAALFM_C703050WA Protein similar to S. cerevisiae Phs1p, which is required for growth; has six putative membrane-spanning regions CAALFM_C703060CA Protein with tetratricopeptide repeats (TPRs); ortholog of S. cerevisiae Chs6, which has role in localizing chitin synthase; Cyr1-regulated in hyphae; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed CAALFM_C703070CA Class III adenylyl cyclase; mutant lacks cAMP; mutant hyphal growth defect rescued by exogenous cAMP; required for mouse mucosal or systemic infection; role in macrophage sensitivity, apoptosis; downstream of Ras1p and CO2 signaling CAALFM_C703080WA Protein involved together with Dck1p and Rac1p in invasive filamentous growth and cell wall integrity; acts upstream of MAP kinase Cek1p; has similarity to human ELMO1 CAALFM_C703090CA Putative flavin-containing monooxygenase; F-12/CO2 early biofilm induced CAALFM_C703110WA Protein similar to S. cerevisiae Wsc2p, which has roles in stress- and cell-wall-related processes; predicted Kex2p substrate; putative GPI-anchored adhesin-like protein CAALFM_C703120WA Predicted component of the mitochondrial TIM22 complex; involved in protein import into mitochondrial inner membrane; Spider biofilm repressed CAALFM_C703130CA Trimethoprim resistant dihydrofolate reductase (DHFR), reduces 7,8-dihydrofolate to 5,4,7,8-tetrahydrofolate; binds NADPH; target of drugs that selectively inhibit the fungal enzyme rather than the human enzyme CAALFM_C703140WA Ortholog of Candida albicans WO-1 : CAWG_05647 CAALFM_C703150WA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_C703160WA Ortholog of C. dubliniensis CD36 : Cd36_72800, Candida tropicalis MYA-3404 : CTRG_05211 and Candida albicans WO-1 : CAWG_05649 CAALFM_C703170WA IPF family A protein; mutants are viable; Spider biofilm induced CAALFM_C703180CA Putative histone H1; farnesol regulated; Hap43-induced; contains 5' UTR intron; Spider biofilm repressed CAALFM_C703200CA Putative pyridoxamine 5'-phosphate oxidase; planktonic growth and early-stage flow model biofilm induced CAALFM_C703210WA Ortholog of C. parapsilosis CDC317 : CPAR2_704140, C. dubliniensis CD36 : Cd36_72870, Lodderomyces elongisporus NRLL YB-4239 : LELG_05208 and Candida orthopsilosis Co 90-125 : CORT_0G04320 CAALFM_C703220CA Zn(II)2Cys6 transcription factor; mutants sensitive to caffeine and menadione, resistant to fenpropimorph; Hap43-repressed; mutants have decreased CFU in mouse kidneys and defects in filamentous growth; Spider biofilm induced CAALFM_C703230CA Protein of unknown function; transcript detected on high-resolution tiling arrays; Spider biofilm induced CAALFM_C703240WA Ortholog of S. cerevisiae Gid7, a GID complex protein; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Hap43-repressed gene CAALFM_C703250CA Putative protein disulfide-isomerase; antigenic in human infection; soluble protein in hyphae; induced by filamentous growth; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm repressed CAALFM_C703260CA Ortholog of C. dubliniensis CD36 : Cd36_72910, C. parapsilosis CDC317 : CPAR2_704100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113193 and Debaryomyces hansenii CBS767 : DEHA2E23100g CAALFM_C703270WA Putative adhesin-like protein CAALFM_C703280CA Protein of unknown function; induced by ketoconazole; Spider, F-12/CO2 and flow model biofilm induced CAALFM_C703290CA Cell wall adhesin-like protein; repressed by Rim101; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C703300CA Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; LIP5 and LIP8 are expressed at all stages of both mucosal and systemic infection CAALFM_C703310WA Protein of unknown function; fluconazole-induced; Spider biofilm induced CAALFM_C703320CA Putative RNA polymerase II mediator complex subunit; induced by nitric oxide CAALFM_C703330CA Mitochondrial serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; protein present in exponential and stationary growth phase yeast cultures CAALFM_C703340CA Putative serine/threonine protein kinase; mutation confers resistance to 5-fluorocytosine (5-FC) CAALFM_C703350CA Putative aldose reductase; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_C703360WA Carboxypeptidase Y; transcript regulated at yeast-hypha transition or macrophage response; induced human neutrophils; regulated by Gcn2 and Gcn4; putative N-glycosylation CAALFM_C703370CA Protein of unknown function; possible COPI-coated vesicle, Golgi apparatus, ribosome localization; rat catheter biofilm repressed CAALFM_C703380WA Ortholog(s) have role in mitochondrial respiratory chain complex assembly and mitochondrial intermembrane space, nucleus localization CAALFM_C703390CA Putative beta 3 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed CAALFM_C703400CA Ortholog of S. cerevisiae Mtr4, an ATP-dependent 3'-5' RNA helicase of the DEAD-box family; Hap43-induced gene; Spider biofilm induced CAALFM_C703410CA Protein of unknown function; repressed by alpha pheromone in SpiderM medium CAALFM_C703420CA Putative membrane transporter; Hap43p-induced gene; mutation confers hypersensitivity to toxic ergosterol analog; shows colony morphology-related gene regulation by Ssn6p CAALFM_C703440WA Putative membrane transporter; Hap43-induced; inducd by Mnl1p under weak acid stress; shows Mob2-dependent hyphal regulation CAALFM_C703450CA Ortholog(s) have role in mismatch repair, proteasome regulatory particle assembly and cytosol, nucleus, proteasome regulatory particle, base subcomplex localization CAALFM_C703460WA Ortholog of Candida albicans WO-1 : CAWG_05678 CAALFM_C703470WA Protein of unknown function; Hap43-repressed gene CAALFM_C703480WA Putative guanyl nucleotide exchange factor with Sec7 domain; required for normal filamentous growth; regulated by yeast-hyphal switch; filament induced; regulated by Nrg1, Tup1, Mob2, Hap43; mRNA binds She3; Spider biofilm induced CAALFM_C703490WA Protein similar to S. cerevisiae Gyp7p (GTPase-activating protein for Ypt1p); caspofungin-induced CAALFM_C703500WA Predicted vacuolar protein with a calcineurin-like phosphoesterase domain; repressed by alpha pheromone in SpiderM medium CAALFM_C703520WA Putative nicotinamidase, involved in NAD salvage pathway; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 CAALFM_C703530CA Putative pre-mRNA-splicing factor; mutation confers resistance to 5-fluorocytosine (5-FC); rat catheter biofilm induced CAALFM_C703540CA Putative nucleolar protein; essential; heterozygous mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Hap43-induced; Spider biofilm induced CAALFM_C703550CA Protein of unknown function; rat catheter biofilm repressed CAALFM_C703560WA Protein of unknown function; expression decreases by benomyl treatment or in an azole-resistant strain overexpressing MDR1; Spider biofilm induced CAALFM_C703570WA Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; alkaline downregulated; flow model biofilm induced; Spider biofilm induced CAALFM_C703580CA Protein of unknown function; Hap43-repressed gene CAALFM_C703590CA Putative ember of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide exporter superfamily; Spider biofilm induced CAALFM_C703600WA Putative alpha-1,2-mannosyltransferase; mutant sensitive to calcofluor, SDS and growth at 42 deg; present in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation and transmembrane helix CAALFM_C703610CA Ortholog(s) have cytosol, nucleus localization CAALFM_C703620CA Ortholog of C. dubliniensis CD36 : Cd36_73320, C. parapsilosis CDC317 : CPAR2_703860, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114480 and Debaryomyces hansenii CBS767 : DEHA2C13794g CAALFM_C703630CA Predicted protein of the mitochondrial intermembrane space; rat catheter biofilm induced; Spider biofilm repressed CAALFM_C703640CA Ortholog(s) have asparagine-tRNA ligase activity, role in mitochondrial asparaginyl-tRNA aminoacylation and mitochondrion localization CAALFM_C703650WA Ortholog(s) have histidinol-phosphatase activity, role in histidine biosynthetic process and cytosol, nucleus localization CAALFM_C703660CA Protein with similarity to amino acid-tRNA ligase; stationary phase enriched protein; GlcNAc-induced protein CAALFM_C703670WA Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures CAALFM_C703680WA Ortholog of C. dubliniensis CD36 : Cd36_73260 and Candida albicans WO-1 : CAWG_05699 CAALFM_C703690WA Ortholog of Candida albicans WO-1 : CAWG_05700 CAALFM_C703700CA Protein required for pre-rRNA processing and 40S ribosomal subunit synthesis; associated with U3 and U14 snoRNAs; transposon mutation affects filamentous growth; repressed by prostaglandins; Spider biofilm induced CAALFM_C703710CA Phosphoinositide-specific phospholipase C (PI-PLC), delta-form; essential; roles in stress resistance, hyphal growth; upregulated in biofilm; predicted N-linked glycosylation; lacks conserved EF-hand domain CAALFM_C703720CA Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; higher protein level in stationary phase CAALFM_C703730CA Ortholog of C. dubliniensis CD36 : Cd36_73400, C. parapsilosis CDC317 : CPAR2_703180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104803 and Debaryomyces hansenii CBS767 : DEHA2A04466g CAALFM_C703760WA Ortholog of C. dubliniensis CD36 : Cd36_73420, Debaryomyces hansenii CBS767 : DEHA2A05456g, Pichia stipitis Pignal : PICST_30999 and Candida guilliermondii ATCC 6260 : PGUG_00155 CAALFM_C703770CA Subunit of the NuA4 histone acetyltransferase complex; transcript regulated by Mig1; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_C703780CA Ortholog(s) have glyoxysome localization CAALFM_C703790WA Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced CAALFM_C703800WA Ortholog(s) have role in ER to Golgi vesicle-mediated transport, protein retention in ER lumen, retrograde vesicle-mediated transport, Golgi to ER CAALFM_C703810WA Actin binding protein with roles in growth control and morphogenesis; required for alkaline pH-induced hyphal formation; localized to actin patches; rat catheter biofilm repressed CAALFM_C703820CA Ortholog of C. dubliniensis CD36 : Cd36_73480, Pichia stipitis Pignal : PICST_30727, Candida tropicalis MYA-3404 : CTRG_05165 and Candida albicans WO-1 : CAWG_05712 CAALFM_C703830CA Ortholog(s) have role in posttranslational protein targeting to membrane and TRC complex, nucleus localization CAALFM_C703840WA CCR4-NOT complex component; involved in controlling mRNA initiation, elongation and degradation; rat catheter biofilm induced CAALFM_C703850WA Putative intranuclear transport and DNA replication mediator; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm induced CAALFM_C703860WA Putative vacuolar protease; upregulated in the presence of human neutrophils; Spider biofilm induced CAALFM_C703870WA Functional ortholog of S. cerevisiae Rad6; negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1; transcript is UV-induced, slightly repressed during hyphal growth; gene has two introns CAALFM_C703880CA Protein required for virulence in reconstituted human epithelium (RHE) model of ex vivo infection; decreased transcription is observed upon fluphenazine treatment; induced upon adherence to polystyrene CAALFM_C703890CA Specificity factor required for ubiquitination; role in protein targeting to vacuole; involved in ubiquitin-dependent protein catabolism via the multivesicular body sorting pathway; Spider biofilm induced CAALFM_C703910WA Mitochondrial glycosylase/lyase; repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance, role in base-excision repair; Spider biofilm induced CAALFM_C703920CA Conserved acidic ribosomal protein, likely involved in regulation of translation elongation; interacts with Rpp2A; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); induced by Tbf1; Spider biofilm repressed CAALFM_C703930CA Putative mitochondrial acidic matrix protein; regulated by Ssn6p; protein present in exponential and stationary growth phase yeast cultures CAALFM_C703940CA B-type mitotic cyclin; nonessential; negative regulator of pseudohyphal growth; dispensible for mitotic exit, cytokinesis; Fkh2-represed; flow model biofilm repressed; farnesol-upregulated in biofilm; reduced total RNA in clb4 mutant CAALFM_C703960CA Ortholog of C. dubliniensis CD36 : Cd36_73630, C. parapsilosis CDC317 : CPAR2_805330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119330 and Debaryomyces hansenii CBS767 : DEHA2G16544g CAALFM_C703970CA Ortholog of C. dubliniensis CD36 : Cd36_73640, C. parapsilosis CDC317 : CPAR2_702340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112965 and Debaryomyces hansenii CBS767 : DEHA2G16566g CAALFM_C703980WA Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization CAALFM_C703990CA Ortholog(s) have RNA binding activity, role in tRNA modification and cytoplasm, nucleus localization CAALFM_C704000WA Ortholog of C. dubliniensis CD36 : Cd36_73670, C. parapsilosis CDC317 : CPAR2_702370, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119320 and Debaryomyces hansenii CBS767 : DEHA2G16632g CAALFM_C704010WA Ortholog(s) have role in intracellular sequestering of iron ion, iron-sulfur cluster assembly, protein maturation and mitochondrial matrix localization CAALFM_C704020CA Alpha6 subunit of the 20S proteasome; regulated by Gcn4; induced in response to amino acid starvation (3-AT); Spider biofilm repressed CAALFM_C704030CA Putative karyopherin; mutation confers hypersensitivity to cytochalasin D CAALFM_C704040CA Putative nicotinate phosphoribosyltransferase, involved in NAD salvage pathway; fungal-specific (no human or murine homolog) CAALFM_C704050WA Putative HSP40 co-chaperone; repressed during the mating process CAALFM_C704060WA Ortholog of C. parapsilosis CDC317 : CPAR2_702310, C. dubliniensis CD36 : Cd36_73730, Lodderomyces elongisporus NRLL YB-4239 : LELG_04029 and Candida orthopsilosis Co 90-125 : CORT_0G02490 CAALFM_C704070CA Ortholog of C. dubliniensis CD36 : Cd36_73740, Candida tropicalis MYA-3404 : CTRG_05151 and Candida albicans WO-1 : CAWG_05736 CAALFM_C704080CA Putative adhesin-like protein CAALFM_C704090CA Predicted mitochondrial cardiolipin-specific phospholipase; upregulated in an azole-resistant strain that overexpresses MDR1; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced CAALFM_C704100CA RNA polymerase II mediator complex subunit; Hap43p-repressed gene CAALFM_C704110WA Ortholog(s) have role in ascospore formation, conidiophore development, conidium formation, regulation of vacuole fusion, non-autophagic and response to oxidative stress, more CAALFM_C704120WA Ortholog of C. dubliniensis CD36 : Cd36_73790, C. parapsilosis CDC317 : CPAR2_702880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92070 and Debaryomyces hansenii CBS767 : DEHA2D10318g CAALFM_C704130CA Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_C704140CA Ortholog(s) have unfolded protein binding activity CAALFM_C704150WA Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YMR185W CAALFM_C704160WA Protein of allantoate permease family; fungal-specific (no human or murine homolog); Hap43p-repressed gene CAALFM_C704170WA Protein with a tubulin binding cofactor C domain; flow model biofilm induced CAALFM_C704180WA Predicted acyl CoA synthetase CAALFM_C704190CA Putative U3 snoRNA-associated protein; Hap43-induced; repressed in core stress response; physically interacts with TAP-tagged Nop1 CAALFM_C704200CA Putative exportin, member of the Exportin-T family; flow model biofilm repressed CAALFM_C704210CA Protein similar to Aspergillus CYSK O-acetylserine sulfhydrylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; upregulated in biofilm; protein level decreases in stationary phase cultures CAALFM_C704230WA Transcription factor/repressor; regulates chlamydospore formation/hyphal gene induction/virulence and rescue/stress response genes; effects both Tup1 dependent and independent regulation; flow model biofilm induced; Spider biofilm repressed CAALFM_C704240CA Putative GTPase inhibitor; predicted role in endocytosis, protein targeting to vacuole; rat catheter biofilm repressed CAALFM_C704250WA Putative polyamine transport protein; fungal-specific (no human or murine homolog) CAALFM_C704260WA Ortholog(s) have GTPase activity, ribosome binding activity and role in nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, positive regulation of translation, ribosome disassembly CAALFM_C704270CA Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic CAALFM_C704280CA Putative catechol o-methyltransferase; stationary phase enriched protein; transcription upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed CAALFM_C704290WA Ortholog(s) have role in mRNA splicing, via spliceosome CAALFM_C704300WA Putative transcription elongation factor; transposon mutation affects filamentous growth; transcript induced in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis CAALFM_C704310CA Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway CAALFM_C704320WA Protein of unknown function; Hap43-repressed gene CAALFM_C704330CA Putative Golgi integral membrane protein; transcript regulated by Mig1 CAALFM_C704340CA Putative protein of unknown function, transcript is upregulated in an RHE model of oral candidiasis CAALFM_C704360CA Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo CAALFM_CR00010CA Protein similarity to mutator-like element (MULE) transposase CAALFM_CR00020WA Member of a family of telomere-proximal genes of unknown function; hypha-induced expression; rat catheter biofilm repressed CAALFM_CR00040CA Putative adhesin-like protein; transcription detected in high-resolution tiling array experiments CAALFM_CR00050WA Transcriptional activator that forms a heterodimer with Ino4p; likely regulates genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis, fatty acid beta-oxidation, and peroxisome biogenesis CAALFM_CR00060CA DNA helicase involved in rDNA replication; Spider biofilm repressed CAALFM_CR00070WA Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absent CAALFM_CR00080WA Mitochondrial C1-tetrahydrofolate synthase precursor CAALFM_CR00090CA Protein of unknown function; stationary phase enriched protein; induced upon yeast-hypha transition; benomyl or caspofungin induced; Hap43-repressed; Spider biofilm induced CAALFM_CR00100CA Subunit of the NuA4 histone acetyltransferase complex CAALFM_CR00110WA Ortholog of C. dubliniensis CD36 : Cd36_25130, C. parapsilosis CDC317 : CPAR2_800100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_107256 and Debaryomyces hansenii CBS767 : DEHA2E18370g CAALFM_CR00120CA MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress CAALFM_CR00130CA Protein with a pyridoxal phosphate-dependent transferase domain; Hap43-repressed; mutation confers hypersensitivity to amphotericin B; Spider biofilm repressed CAALFM_CR00140WA Protein involved in negative regulation of MDR1 transcription; mutants show increased resistance to azole drugs CAALFM_CR00150CA Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by Nrg1 and Mig1; farnesol regulated; Hap43-repressed CAALFM_CR00160CA Ortholog of C. dubliniensis CD36 : Cd36_25180, C. parapsilosis CDC317 : CPAR2_800030, Candida tenuis NRRL Y-1498 : CANTEDRAFT_125790 and Debaryomyces hansenii CBS767 : DEHA2E18260g CAALFM_CR00170WA Putative Zn(II)2Cys6 transcription factor CAALFM_CR00180CA Chitinase; putative N-terminal catalytic domain; has secretory signal sequence; lacks S/T region and N-glycosylation motifs of Chs2p and Chs3p; alkaline downregulated; expression not detected in yeast-form or hyphal cells CAALFM_CR00190WA Putative glycoside hydrolase; Hap43-induced gene CAALFM_CR00200WA Phosphoenolpyruvate carboxykinase; glucose, C-source, yeast-hypha, Hap43 regulated; fluconazole, phagocytosis, H2O2, oral candidasis, Spider/rat catheter/flow model biofilm induced; repressed in biofilm by Bcr1, Tec1, Ndt80, Rob1, Brg1 CAALFM_CR00210WA N-Alkane inducible cytochrome P450 CAALFM_CR00220WA Has domain(s) with predicted electron carrier activity, heme binding, iron ion binding, monooxygenase activity, oxidoreductase activity and acting on paired donors, more CAALFM_CR00230WA Ortholog(s) have structural constituent of nuclear pore activity, role in nuclear pore organization and cytosol, mitotic spindle pole body, nuclear periphery, nuclear pore inner ring localization CAALFM_CR00240WA Putative Lsm protein; flucytosine induced CAALFM_CR00250WA Mitochondrial ATPase complex subunit; downregulated by Efg1p; flucytosine induced; caspofungin repressed CAALFM_CR00260WA Protein with similarity to S. cerevisiae Kin2p, transcription is positively regulated by Tbf1 CAALFM_CR00270CA Ortholog of C. dubliniensis CD36 : Cd36_25310, Pichia stipitis Pignal : PICST_30877, Candida tropicalis MYA-3404 : CTRG_01053 and Candida lusitaniae ATCC 42720 : CLUG_02644 CAALFM_CR00280CA Ortholog(s) have ATPase activity, DNA binding, nucleosome binding activity, role in chromatin remodeling and Isw1b complex localization CAALFM_CR00290WA Ortholog of S. cerevisiae Rts3; a component of the protein phosphatase type 2A complex; Plc1-regulated; induced in core caspofungin response; Spider biofilm induced CAALFM_CR00300WA Putative chitin deacetylase; transcription is positively regulated by Tbf1p CAALFM_CR00310CA Protein of unknown function; Hap43-induced gene; upregulated in a cyr1 null mutant; Spider biofilm induced CAALFM_CR00320CA Nucleosome assembly protein; mutants show constitutive filamentous growth; present in exponential and stationary growth phase yeast cultures CAALFM_CR00330CA Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC family transporter CAALFM_CR00340CA Ortholog of C. parapsilosis CDC317 : CPAR2_800380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114079, Pichia stipitis Pignal : psti_CGOB_00127 and Candida orthopsilosis Co 90-125 : CORT_0A00460 CAALFM_CR00350WA Putative nicotinic acid mononucleotide adenylyltransferase, involved in NAD salvage pathway; Spider biofilm repressed CAALFM_CR00360CA 3-isopropylmalate dehydratase; antigenic in humans; repressed in hyphae; alkaline repressed; upregulated by human whole blood or PMNs; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm induced, Spider biofilm repressed CAALFM_CR00370WA Ortholog(s) have ubiquitin-protein transferase activity, role in protein ubiquitination involved in ubiquitin-dependent protein catabolic process and Cul3-RING ubiquitin ligase complex, cytoplasm, nucleus localization CAALFM_CR00380WA Protein with NADPH oxidoreductase containing flavin mononucleotide (FMN) domain; induced by nitric oxide CAALFM_CR00390WA Putative adapter subunit of E3 ubiquitin ligase complex, acts with cullin subunit Rtt101p in response to DNA damage; cell-cycle regulated periodic mRNA expression CAALFM_CR00400CA Subunit of the NuA4 histone acetyltransferase complex CAALFM_CR00410WA Histone acetyltransferase, mutants are sensitive to DNA damage, show decreased virulence in mice, decreased white-to-opaque switching and increased susceptibility to killing by macrophages CAALFM_CR00420WA Predicted membrane transporter; fucose:proton symporter family member, MFS superfamily; flow model biofilm induced CAALFM_CR00430CA Ortholog(s) have role in negative regulation of transcription from RNA polymerase II promoter in response to iron and cytosol, nucleus localization CAALFM_CR00440CA Ortholog(s) have GTPase activator activity CAALFM_CR00460CA Component of the SSU processome; predicted role in pre-18S rRNA processing; Spider biofilm induced CAALFM_CR00470WA Has domain(s) with predicted RNA binding, RNA-directed DNA polymerase activity and role in RNA-dependent DNA replication CAALFM_CR00480WA Putative mitochondrial ribosomal protein CAALFM_CR00490WA Putative mitochondrial ribosomal protein of the large subunit; Hap43p-repressed gene; ortholog of S. cerevisiae MRPL9 CAALFM_CR00510CA Phosphoribosylaminoimadazole succinocarboxamide synthetase, enzyme of adenine biosynthesis; not induced in GCN response, unlike the S. cerevisiae ortholog; fungal-specific (no human or murine homolog); levels decrease in stationary phase CAALFM_CR00520CA Functional homolog of S. cerevisiae Crm1, which acts in protein nuclear export; predicted to be resistant to antifungal drug leptomycin B; partially suppresses signal transduction defects of S. cerevisiae ste20 mutant CAALFM_CR00530WA Ortholog of C. parapsilosis CDC317 : CPAR2_803740, C. dubliniensis CD36 : Cd36_25640, Lodderomyces elongisporus NRLL YB-4239 : LELG_00467 and Candida orthopsilosis Co 90-125 : CORT_0A03760 CAALFM_CR00540CA Mitochondrial malate dehydrogenase; regulated by Mig1, Tup1, white-opaque switch, phagocytosis; induced in high iron; antigenic during murine and human infection; repressed in Spider biofilms by Bcr1, Tec1, Ndt80, Rob1, Brg1 CAALFM_CR00560WA Neutral trehalase; hyphal induction in mutant delayed but not reduced overall; not required for virulence in mice; possible regulatory cAMP-dependent phosphorylation at S10,S213; Hap43-repressed gene; Spider biofilm induced CAALFM_CR00570WA Ortholog(s) have di-trans,poly-cis-decaprenylcistransferase activity, trans-hexaprenyltranstransferase activity, role in ubiquinone biosynthetic process and decaprenyl diphosphate synthase complex, mitochondrion localization CAALFM_CR00580WA Functional homolog of S. cerevisiae Yrb1p; regulates Gsp1 GTPase activity and thereby affects nucleocytoplasmic transport and cytoskeletal dynamics; transcript is not regulated by white-opaque switch or by dimorphic transition CAALFM_CR00590WA Protein involved in regulation of hyphal development; required for response to farnesoic acid; possibly adherence-induced CAALFM_CR00600CA Ortholog(s) have role in endocytosis and actin cortical patch, cellular bud neck, cytoplasm localization CAALFM_CR00610WA Adhesin-like cell surface protein; putative GPI-anchor; null mutant germ tubes show decreased adhesion to plastic substrate; mutants are viable; Hap43-repressed gene CAALFM_CR00620CA Argininosuccinate synthase; arginine synthesis; Gcn4, Rim101 regulated; induced by amino acid starvation (3-AT), benomyl treatment; stationary phase enriched protein; repressed in alkalinizing medium; rat catheter, Spider biofilm induced CAALFM_CR00630WA Putative transcriptional activator; expression upregulated during growth in the mouse cecum; Spider biofilm induced CAALFM_CR00640WA Putative acetyl-coenzyme-A carboxylases; regulated by Efg1; amphotericin B repressed; caspofungin repressed; 5'-UTR intron; gene used for strain identification by multilocus sequence typing; Hap43-induced; flow model biofilm repressed CAALFM_CR00650WA Putative subtilisin-family protease; mutation confers hypersensitivity to toxic ergosterol analog CAALFM_CR00660WA Ortholog(s) have role in ascospore wall assembly and ascospore wall, nuclear envelope localization CAALFM_CR00670CA Putative 2'-O-methyltransferase with a predicted role in tRNA modification; transcription is activated in the presence of elevated CO2 CAALFM_CR00680WA Protein with a predicted role in 18S rRNA maturation and small ribosomal subunit biogenesis; repressed in core stress response; repressed by prostaglandins CAALFM_CR00690CA Ortholog(s) have alpha-1,4-glucosidase activity, role in polysaccharide biosynthetic process, protein N-linked glycosylation and endoplasmic reticulum lumen, glucosidase II complex localization CAALFM_CR00700WA Ortholog of C. dubliniensis CD36 : Cd36_25800, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116265, Debaryomyces hansenii CBS767 : DEHA2E17380g and Pichia stipitis Pignal : PICST_62836 CAALFM_CR00710CA Ortholog(s) have 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity, role in aerobic respiration, fatty acid metabolic process and mitochondrion localization CAALFM_CR00720WA Ortholog of Candida albicans WO-1 : CAWG_01431 CAALFM_CR00740CA Beta-mannosyltransferase; adds 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan, elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction; Hap43-induced; Spider biofilm induced CAALFM_CR00750CA Ortholog(s) have histone demethylase activity (H3-K36 specific), methylated histone binding activity and role in histone demethylation, positive regulation of transcription elongation from RNA polymerase II promoter CAALFM_CR00760CA Putative GPI-anchored adhesin-like protein; Rim101-repressed; constitutive expression independent of MTL or white-opaque status CAALFM_CR00780CA UDP glucose/starch glucosyltransferase; transcript repressed by yeast-hyphal switch, Efg1-regulated; strong oxidative stress induced; colony morphology-related regulation by Ssn6; stationary phase enriched; flow model biofilm induced CAALFM_CR00800CA Putative 90S pre-ribosomal component; repressed in core stress response; repressed by prostaglandins; physically interacts with TAP-tagged Nop1; Hap43-induced CAALFM_CR00810WA Ortholog of C. dubliniensis CD36 : Cd36_25870, C. parapsilosis CDC317 : CPAR2_804000, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115661 and Debaryomyces hansenii CBS767 : DEHA2B05852g CAALFM_CR00820CA Ortholog(s) have actin monomer binding, protein kinase inhibitor activity, ribosome binding activity, role in negative regulation of protein phosphorylation and cytoplasm, nucleus, polysome, ribosome localization CAALFM_CR00830WA Ortholog(s) have chaperone binding activity, role in box C/D snoRNP assembly, protein folding and R2TP complex, cytoplasm, nucleus localization CAALFM_CR00840CA Ortholog of Candida albicans WO-1 : CAWG_01442 CAALFM_CR00850CA Protein similar to beta-1,3-glucan synthase; 16 predicted membrane-spanning regions; transcript regulated by Nrg1; very low gene expression in yeast-form and hyphal cells CAALFM_CR00860CA Cell wall protein, ortholog of S. cerevisiae Tma19p (Ykl065cp) CAALFM_CR00870CA Ortholog(s) have palmitoyltransferase activity and role in ascospore wall assembly, cortical actin cytoskeleton organization, establishment of cell polarity, protein palmitoylation, regulation of exocytosis, vacuole fusion, non-autophagic CAALFM_CR00880WA Ortholog of C. dubliniensis CD36 : Cd36_25930, C. parapsilosis CDC317 : CPAR2_800910, Candida tenuis NRRL Y-1498 : CANTEDRAFT_132053 and Debaryomyces hansenii CBS767 : DEHA2E17160g CAALFM_CR00890CA Ortholog of C. parapsilosis CDC317 : CPAR2_800920, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109948, Debaryomyces hansenii CBS767 : DEHA2E17182g and Pichia stipitis Pignal : psti_CGOB_00115 CAALFM_CR00900WA Putative N2,N2-dimethylguanine tRNA methyltransferase; induced upon adherence to polystyrene CAALFM_CR00910WA Protein of unknown function; Spider biofilm repressed CAALFM_CR00920WA Putative Holliday junction resolving enzyme; similar to S. cerevisiae Cce1p CAALFM_CR00930WA Putative fungal-specific transmembrane protein; rat catheter and Spider biofilm induced CAALFM_CR00970WA Putative fungal-specific transmembrane protein CAALFM_CR00980CA Ortholog(s) have phosphopantothenoylcysteine decarboxylase activity, role in coenzyme A biosynthetic process, response to salt stress and CoA-synthesizing protein complex, phosphopantothenoylcysteine decarboxylase complex localization CAALFM_CR00990WA Ortholog(s) have peptidase activity, role in protein targeting to ER, signal peptide processing and signal peptidase complex localization CAALFM_CR01000CA Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; mutants are sensitive to growth on H2O2 medium; rat catheter and Spider biofilm induced CAALFM_CR01010WA Protein involved in telomere maintenance; forms a complex with Stn1; transcription is regulated upon yeast-hypha switch; Spider biofilm induced CAALFM_CR01020CA Ortholog of C. dubliniensis CD36 : Cd36_26020, Candida tropicalis MYA-3404 : CTRG_00984 and Candida albicans WO-1 : CAWG_01455 CAALFM_CR01030WA Zn(II)2Cys6 transcription factor; ortholog of S. cerevisiae Dal81, involved in the regulation of nitrogen-degradation genes; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_CR01040CA Putative ARP2/3 complex subunit; Hap43-induced gene; mutation confers hypersensitivity to cytochalasin D; rat catheter biofilm repressed CAALFM_CR01050CA Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U1 snRNP, U2-type prespliceosome localization CAALFM_CR01060WA Putative ceramide synthase component; Hap43p-repressed gene; amphotericin B repressed CAALFM_CR01070WA Ortholog of C. dubliniensis CD36 : Cd36_26070, C. parapsilosis CDC317 : CPAR2_803220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_131795 and Debaryomyces hansenii CBS767 : DEHA2E12694g CAALFM_CR01080WA Putative ortholog of S. cerevisiae Laa1p; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_CR01090WA Ortholog of C. dubliniensis CD36 : Cd36_26090, C. parapsilosis CDC317 : CPAR2_801510, Candida tenuis NRRL Y-1498 : CANTEDRAFT_137093 and Debaryomyces hansenii CBS767 : DEHA2F20548g CAALFM_CR01100CA Ortholog(s) have role in mitochondrial respiratory chain complex assembly and mitochondrion localization CAALFM_CR01110WA Putative signal recognition particle (SRP) subunit; induced in ssr1 null; Spider biofilm repressed CAALFM_CR01120CA Putative TFIID and SAGA complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR01130WA Ortholog(s) have role in positive regulation of TORC1 signaling and Seh1-associated complex, extrinsic component of fungal-type vacuolar membrane localization CAALFM_CR01140CA 3-Keto sterol reductase of ergosterol biosynthesis; acts in C-4 sterol demethylation with Erg25p and Erg26p; possible drug target, essential for viability; functional homolog of S. cerevisiae Erg27p CAALFM_CR01150CA Protein with a predicted role in sister chromatid cohesion; cell-cycle regulated periodic mRNA expression CAALFM_CR01170WA Ortholog(s) have role in free ubiquitin chain polymerization, negative regulation of telomerase activity and cytosol, mitochondrion, nucleus localization CAALFM_CR01180WA Putative F-actin capping protein subunit alpha; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR01190CA Putative Golgi v-SNARE; Plc1-regulated; Spider biofilm induced CAALFM_CR01200WA Putative NADPH dehydrogenase; rat catheter biofilm induced CAALFM_CR01210CA ESCRT-0 complex subunit; SH3-domain-containing protein CAALFM_CR01220WA Putative transporter; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog) CAALFM_CR01230CA Putative ubiquitin-protein ligase; periodic mRNA expression, peak at cell-cycle S/G2 phase CAALFM_CR01240CA Putative SH3-domain-containing protein; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced CAALFM_CR01250CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_CR01260WA Putative endosomal transmembrane protein; Hap43p-induced; mutation confers hypersensitivity to amphotericin B CAALFM_CR01270CA Putative iron transporter; similar to S. cerevisiae Fth1p CAALFM_CR01280CA Ortholog(s) have role in intracellular sterol transport and extracellular region, fungal-type vacuole lumen localization CAALFM_CR01290CA Putative sensor/transporter protein with a predicted role in cell wall biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method; flow model and rat catheter biofilm repressed CAALFM_CR01300WA Putative 12kDa subunit of mitochondrial NADH-ubiquinone oxidoreductase; gene has intron CAALFM_CR01310WA F1-ATP synthase complex subunit; caspofungin repressed; flucytosine and macrophage/pseudohyphal-induced; present in exponential and stationary growth phases; Hap43p-induced gene CAALFM_CR01320CA Predicted vacuolar protein; rat catheter biofilm repressed; flow model biofilm repressed CAALFM_CR01330WA Putative arginine-specific carbamoylphosphate synthetase; protein enriched in stationary phase yeast cultures; rat catheter biofilm induced; Spider biofilm induced CAALFM_CR01340WA Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) CAALFM_CR01350CA Ortholog(s) have ATPase activator activity, soluble NSF attachment protein activity CAALFM_CR01360WA Ortholog(s) have role in chromosome segregation and nuclear MIS12/MIND complex localization CAALFM_CR01370CA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_CR01380WA Ortholog of C. dubliniensis CD36 : Cd36_26390, Debaryomyces hansenii CBS767 : DEHA2C05302g, Pichia stipitis Pignal : PICST_68531 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_59916 CAALFM_CR01390WA Putative mitochondrial matrix cochaperone; macrophage/pseudohyphal-repressed CAALFM_CR01400WA Homoisocitrate dehydrogenase; catalyzes 4th step in the alpha-aminoadipate pathway of lysine biosynthesis; clade-associated gene expression; protein level decreases in stationary phase cultures; Spider biofilm repressed CAALFM_CR01410CA Putative protein of unknown function; Hap43-induced; required for normal biofilm growth; F-12/CO2 early biofilm induced CAALFM_CR01420WA Putative RNA polymerase III transcription factor (TFIIIB) subunit; flucytosine repressed CAALFM_CR01430WA Ortholog of S. cerevisiae Gpa15; involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors; shuman Pig-H, which is also involved in GPI assembly; Spider biofilm induced CAALFM_CR01440CA Protein of unknown function; Spider biofilm repressed CAALFM_CR01470WA Hyphal cell wall protein; role in progression of mouse systemic infection; predicted P-loop, divalent cation binding, N-glycosylation sites; expressed in yeast and hyphae; hyphal downregulated; stationary-phase enriched; GlcNAc-induced CAALFM_CR01480WA Putative prolyl-tRNA synthetase; monofunctional Class II synthetase; gene is constitutively expressed CAALFM_CR01490CA Protein with a predicted role in protein translocation from the endoplasmic reticulum CAALFM_CR01500WA Protein with similarity to S. cerevisiae Pin4p; transposon mutation affects filamentous growth CAALFM_CR01510CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_CR01520WA Protein phosphatase of the Type 2C-related family (serine/threonine-specific) with a potential role in DNA damage checkpoint control; localizes to both cytoplasm and mitochondria; mutant shows virulence defect CAALFM_CR01530CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_CR01540WA Similar to silencing proteins; increased transcription is observed upon fluphenazine treatment; rat catheter biofilm repressed CAALFM_CR01550CA Ortholog(s) have 3'-5'-exodeoxyribonuclease activity, endonuclease activity, role in apoptotic DNA fragmentation, cellular response to oxidative stress and cytosol, nucleus localization CAALFM_CR01560WA Ortholog(s) have nucleus localization CAALFM_CR01570WA Ortholog(s) have aminoacyl-tRNA hydrolase activity, role in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and mitochondrial outer membrane localization CAALFM_CR01580CA Protein with a predicted role in telomeric gene silencing and filamentation; repressed by high-level peroxide stress; Spider biofilm induced CAALFM_CR01590CA Putative anthranilate synthase with a predicted role in tryptophan biosynthesis; regulated by Gcn2p and Gcn4p CAALFM_CR01600CA Has domain(s) with predicted RNA binding, ribonuclease activity CAALFM_CR01610CA Regulator of the type 1 protein phosphatase Glc7p activity, involved in control of morphogenesis, progression through the cell cycle and response to DNA damage CAALFM_CR01620CA Essential 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase); antigenic in murine/human systemic infection; heat shock, estrogen, GCN-induced; Spider biofilm repressed CAALFM_CR01630CA Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2553; unmerged from orf19.2553 in a revision of Assembly 21 CAALFM_CR01640CA Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2552 in Assembly 20; unmerged from orf19.2552 in a revision of Assembly 21 CAALFM_CR01650WA Putative orotate phosphoribosyltransferase; protein abundance is affected by URA3 expression in the CAI-4 strain background; flucytosine induced; protein level decreased in stationary phase cultures CAALFM_CR01660CA Component of the protein-targeting Signal Recognition Particle (SRP); similar to mammalian Srp19; functional homolog of S. cerevisiae Sec65; Tbf1-induced CAALFM_CR01670WA Has domain(s) with predicted zinc ion binding activity and nucleus localization CAALFM_CR01680CA F-box subunit of SCF(CDC4) ubiquitin ligase; functional homolog of S. cerevisiae Cdc4; mutation/depletion causes hyperfilamentation; Sol1 is a substrate of SCF-Cdc4; Spider biofilm induced CAALFM_CR01690CA Cytosolic leucyl tRNA synthetase; conserved amino acid and ATP binding class I signature, tRNA binding, proofreading motifs; likely essential for growth; interacts with benzoxaborole antifungals; present in exponential and stationary phase CAALFM_CR01700CA Ortholog(s) have U6 snRNA binding activity, role in spliceosomal complex assembly, spliceosomal tri-snRNP complex assembly and U6 snRNP localization CAALFM_CR01710WA Putative nucleolar protein; implicated in ribosome biogenesis; rat catheter biofilm repressed CAALFM_CR01720WA Predicted intermediate filament protein; required for nuclear and mitochondrial transmission to daughter buds in S. cerevisiae; Spider biofilm induced CAALFM_CR01730WA Predicted membrane protein; estradiol-induced; upregulation associated with CDR1 and CDR2 overexpression or fluphenazine; putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p; Hap43-repressed; Spider biofilm repressed CAALFM_CR01740WA Putative NADH-ubiquinone dehydrogenase; Hap43p-repressed gene CAALFM_CR01750CA Small GTPase of Rab family; role in post-Golgi secretion; possible C-terminal palmitoylation; downregulated on adherence to polystyrene; localizes to the Spitzenkorper during hyphal growth; functional homolog of S. cerevisiae Sec4p CAALFM_CR01760CA Phenylalanyl-tRNA synthetase; possible role in early cell wall biosynthesis; downregulated by phagocytosis by macrophages; possibly essential gene, disruptants not obtained by UAU1 method; protein present in exponential and stationary phase CAALFM_CR01770CA Ortholog of S. cerevisiae : MIL1, C. glabrata CBS138 : CAGL0K12584g, C. dubliniensis CD36 : Cd36_26790, C. parapsilosis CDC317 : CPAR2_800820 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_128475 CAALFM_CR01780WA Putative S-adenosylmethionine-dependent methyltransferase; Hap43p-induced gene CAALFM_CR01790CA Msh4 ortholog of S. cerevisiae; involved in meiotic recombination and is required for normal levels of crossing over; Spider biofilm induced CAALFM_CR01800CA Putative histone deacetylase; role in regulation of white-opaque switch; Spider biofilm induced CAALFM_CR01810CA Protein with a predicted epimerase/dehydratase domain; Hap43-repressed gene CAALFM_CR01820WA Ortholog(s) have mRNA binding, ribosomal large subunit binding, tRNA binding activity and role in peptide biosynthetic process, ribosome-associated ubiquitin-dependent protein catabolic process CAALFM_CR01830CA Oligopeptide transporter involved in uptake of di-/tripeptides; highly induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_CR01900CA Putative transporter; Hap43, flucytosine repressed; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm induced CAALFM_CR01910CA Putative dethiobiotin synthetase; transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Hap43-repressed; GlcNAc-induced protein; Spider biofilm induced CAALFM_CR01920WA Ortholog(s) have adenosylmethionine-8-amino-7-oxononanoate transaminase activity and role in biotin biosynthetic process CAALFM_CR01930CA Putative biotin synthase; induced by high iron; repressed by ciclopirox olamine; upregulated in clinical isolates from HIV+ patients with oral candidiasis; Hap43-repressed; Spider biofilm induced CAALFM_CR01950WA Ortholog(s) have RNA polymerase I activity, role in transcription of nuclear large rRNA transcript from RNA polymerase I promoter and DNA-directed RNA polymerase I complex, cytosol localization CAALFM_CR01960CA Putative magnesium ion transporter, mitochondrial; fungal-specific (no human or murine homolog) CAALFM_CR01970CA H+ transporting ATPase E chain; transcript regulated by Mig1; caspofungin repressed; protein level decreases in stationary phase cultures; rat catheter biofilm repressed CAALFM_CR01980CA Mitochondrial carnitine carrier protein CAALFM_CR01990CA Putative component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; periodic mRNA expression, peak at cell-cycle S/G2 phase CAALFM_CR02000CA Putative 5-aminolevulinate synthase; caspofungin repressed; induced by high iron, nitric oxide; regulated by Ssn6; Hap43-repressed; Spider biofilm induced CAALFM_CR02020CA Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated; flow model biofilm induced CAALFM_CR02030CA S. pombe ortholog SPAC2C4.06c is a predicted tRNA (cytosine-5-)-methyltransferase; Spider biofilm induced CAALFM_CR02040WA Putative protein serine/threonine kinase; mutants sensitive to growth on hydrogen peroxide medium CAALFM_CR02050CA Histone deacetylase; inducer of filamentation; conserved deacetylation motif; regulates white-to-opaque switch frequency but not opaque-to-white switch; greater expression in white cells than opaque cells; inhibited by trichostatin-A CAALFM_CR02060WA Protein of unknown function; Spider biofilm induced CAALFM_CR02070CA Putative alcohol dehydrogenase; regulated by white-opaque switch; fluconazole-induced; antigenic in murine infection; regulated by Nrg1, Tup1; Hap43, macrophage repressed, flow model biofilm induced; Spider biofilm induced CAALFM_CR02090CA mRNA 5'-triphosphatase; large subunit of mRNA capping enzyme; positively regulates Ceg1 activity; functional homolog of S. cerevisiae Cet1; Cet1 and Cgt1 form a 2:1 complex; flow model biofilm induced CAALFM_CR02100CA Putative tRNA binding protein; intron-containing gene; Spider biofilm induced CAALFM_CR02110WA Putative MCM DNA replication initiation complex component; mRNA expression peak at cell-cycle M/G1 phase; regulated by tyrosol and cell density; repressed by alpha pheromone in SpiderM medium; Hap43-induced gene CAALFM_CR02120CA C2H2 zinc finger transcription factor; expression reduced in ssr1 null mutant; flow model biofilm induced CAALFM_CR02130WA Cytoplasmic glutathione S-transferase; regulated by Nrg1, Tup1; induced in core stress response, in cyr1 or ras1 mutant (yeast or hyphal cells); Tn mutation affects filamentous growth; stationary phase enriched; Spider biofilm induced CAALFM_CR02140WA RAS-related protein; GTP/GDP cycling required for wild-type polar bud site selection, hyphal growth guidance; role in systemic virulence in mouse; geranylgeranylation predicted; suppresses S. cerevisiae cdc24-4 mutant heat sensitivity CAALFM_CR02150WA Putative mitochondrial, half-size MDR-subfamily ABC transporter CAALFM_CR02160WA UDP-glucose:sterol glucosyltransferase; enzyme of sterol glucoside (membrane-bound lipid) biosynthesis; has UDP-sugar binding domain; activity is UDP-glucose-specific in vitro; enzyme does not use UDP-mannose; Mig1-regulated CAALFM_CR02170WA Homoserine acetyltransferase; Hap43p-, Gcn4p-regulated; macrophage/pseudohyphal-repressed; not highly biofilm induced, in contrast to many sulfur amino acid metabolic genes; no human or murine homolog; virulence-group-correlated expression CAALFM_CR02180WA Putative constitutive acid phosphatase; Rim101-repressed; DTT-extractable; N-glycosylated; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR02190CA Zn2-Cys6 transcription factor; regulates iron uptake; negatively regulated by Sfu1p, positively regulated by Tbf1; promotes virulence in mice; mutants display decreased colonization of mouse kidneys; Spider biofilm induced CAALFM_CR02200CA Protein involved in homologous recombination and DNA repair; flucytosine induced; slow growth and increased white-to-opaque switching frequency in null mutant CAALFM_CR02210WA Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR02220CA Oligopeptide transporter; transcript induced by macrophage phagocytosis, BSA or peptides; fluconazole-induced; induced by Rim101 at pH 8; virulence-group-correlated expression; Hap43-repressed; Spider biofilm induced CAALFM_CR02240CA Oligopeptide transporter; induced upon phagocytosis by macrophage; macrophage/pseudohyphal-repressed after 16h; fluconazole-induced; virulence-group-correlated expression; Hap43-repressed CAALFM_CR02250CA Ortholog(s) have tRNA binding activity, role in tRNA export from nucleus and cytoplasm, nuclear pore localization CAALFM_CR02260CA Ortholog of C. dubliniensis CD36 : Cd36_27230, C. parapsilosis CDC317 : CPAR2_801320, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113198 and Debaryomyces hansenii CBS767 : DEHA2E23782g CAALFM_CR02270CA Protein of unknown function; Spider biofilm induced; upregulated in a cyr1 null mutant CAALFM_CR02280WA Putative GPI-anchored protein of unknown function; Rim101-repressed; Cyr1-regulated; colony morphology-related gene regulation by Ssn6 CAALFM_CR02290WA Putative GPI-anchored protein; adhesin-like protein CAALFM_CR02300CA Protein with a Vps9 vacuolar protein sorting protein domain; Hap43-repressed; repressed by ciclopirox olamine; Spider biofilm induced CAALFM_CR02330CA Transcription factor; required for gene regulation in response to pheromones; ortholog of S. cerevisiae Kar4; role in karyogamy; opaque-specific, a-specific; induced by alpha factor CAALFM_CR02340WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_CR02350CA Member of the voltage chloride channel family; Hap43p-repressed gene CAALFM_CR02360WA Isocitrate dehydrogenase; white-opaque switch regulated; morphology-regulation by Ssn6; protein in exponential and stationary phase yeast; Hap43-repressed; Spider biofilm repressed by Bcr1, Tec1, Ndt80, Rob1, Brg1; Spider biofilm induced CAALFM_CR02370WA Putative C-4 methyl sterol oxidase; C4-demethylation of ergosterol biosynthesis intermediates, based on similarity to S. cerevisiae Erg25; fluconazole-induced; induced in azole-resistant strain; rat catheter and Spider biofilm induced CAALFM_CR02380CA Protein similar to S. cerevisiae Kre27p, which has a role in resistance to killer toxin; predicted Kex2p substrate CAALFM_CR02390WA Ortholog(s) have protein phosphatase 1 binding, protein phosphatase type 1 regulator activity, role in chromosome segregation, regulation of phosphoprotein phosphatase activity and cytoplasm localization CAALFM_CR02400WA Putative constitutive acid phosphatase; Rim101-repressed; DTT-extractable; N-glycosylated; Hap43-induced; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR02410WA Ortholog of C. dubliniensis CD36 : Cd36_65640 and Candida albicans WO-1 : CAWG_01583 CAALFM_CR02420WA Ortholog(s) have small ribosomal subunit rRNA binding activity CAALFM_CR02430CA Predicted protein of rapamycin resistance; Spider biofilm induced CAALFM_CR02440WA Protein of unknown function; Spider biofilm induced CAALFM_CR02460WA Ortholog(s) have role in positive regulation of endo-1,4-beta-xylanase activity and SCF ubiquitin ligase complex, cytoplasm localization CAALFM_CR02490WA Oligopeptide transporter; detected at germ tube plasma membrane; transcript inducede during phagocytosis by macrophages; fungal-specific; Hap43-repressed; merged with orf19.2292 in Assembly 20; rat catheter and Spider biofilm induced CAALFM_CR02500WA Ortholog of C. dubliniensis CD36 : Cd36_27430, C. parapsilosis CDC317 : CPAR2_802450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113969 and Debaryomyces hansenii CBS767 : DEHA2A13002g CAALFM_CR02510WA C2H2 transcription factor; induced by Mnl1 under weak acid stress CAALFM_CR02520WA Putative RNA polymerases I and III subunit AC19; Hap43-induced; rat catheter biofilm induced CAALFM_CR02530WA Putative DEAD-box family ATP-dependent RNA helicase; flucytosine induced; repressed in core stress response CAALFM_CR02540WA Putative phosphatidyl-ethanolamine N-methyltransferase; fungal-specific (no human or murine homolog); amphotericin B repressed; Hap43p-induced gene CAALFM_CR02550CA Ortholog(s) have role in U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_CR02560CA Gal4p family zinc-finger transcription factor with similarity to S. cerevisiae Asg1p CAALFM_CR02570CA Ortholog(s) have triglyceride lipase activity, role in triglyceride catabolic process and peroxisomal matrix localization CAALFM_CR02580WA Ortholog(s) have pantoate-beta-alanine ligase activity, role in pantothenate biosynthetic process and cytosol, nucleus localization CAALFM_CR02590CA Ortholog(s) have RNA-dependent ATPase activity, second spliceosomal transesterification activity and role in RNA exon ligation, generation of catalytic spliceosome for second transesterification step CAALFM_CR02600WA Ortholog of C. dubliniensis CD36 : Cd36_27570, C. parapsilosis CDC317 : CPAR2_801010, Candida tenuis NRRL Y-1498 : cten_CGOB_00198 and Debaryomyces hansenii CBS767 : DEHA2E09306g CAALFM_CR02610CA Ortholog(s) have nucleocytoplasmic transporter activity, structural constituent of nuclear pore activity and role in NLS-bearing protein import into nucleus, nuclear pore organization, protein targeting to nuclear inner membrane CAALFM_CR02620CA Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide CAALFM_CR02630CA Essential component of the conserved oligomeric Golgi complex; role in fusion of transport vesicles to Golgi compartments; rat catheter biofilm repressed CAALFM_CR02640WA HMG domain transcriptional repressor of filamentous growth and hyphal genes; in Tup1-dependent and -independent pathways; binds DNA; transcript not regulated by oxygen or serum; not responsible for hypoxic repression; Spider biofilm induced CAALFM_CR02650CA Putative cytosolic Fe-S protein assembly protein; a-specific transcript; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced CAALFM_CR02670CA Ortholog of C. dubliniensis CD36 : Cd36_27680, C. parapsilosis CDC317 : CPAR2_801140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_129982 and Debaryomyces hansenii CBS767 : DEHA2E09526g CAALFM_CR02680WA Ortholog(s) have structural constituent of cytoskeleton activity CAALFM_CR02690WA Ortholog(s) have alpha-tubulin binding, microtubule binding activity, role in cytoplasmic microtubule organization, establishment or maintenance of cell polarity, post-chaperonin tubulin folding pathway and cytosol, nucleus localization CAALFM_CR02700WA Ortholog(s) have role in protein transport and endoplasmic reticulum, nuclear envelope localization CAALFM_CR02710WA Ribosomal protein; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); physically interacts with TAP-tagged Nop1; Hap43-induced; Spider biofilm induced CAALFM_CR02720CA Putative RNA polymerase III subunit C31; repressed by nitric oxide; induced during infection of murine kidney, compared to growth in vitro; has murine homolog CAALFM_CR02740WA Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain CAALFM_CR02750CA Putative GPI-anchored protein; transcript repressed by alpha pheromone in SpiderM medium; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm induced CAALFM_CR02760CA Histone deacetylase; regulates frequency of white-to-opaque and opaque-to-white switching; greater expression in white cells than opaque cells; has conserved deacetylation motif CAALFM_CR02770CA Ortholog(s) have SUMO activating enzyme activity, role in protein sumoylation and SUMO activating enzyme complex, cytosol localization CAALFM_CR02780WA Protein with similarity to carbonic anhydrases CAALFM_CR02790CA Putative glucosyltransferase involved in cell wall mannan biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR02800CA Protein of unknown function; mutation confers hypersensitivity to amphotericin B; flow model biofilm induced CAALFM_CR02810WA Cirt family transposase; transcript repressed in an azole-resistant strain that overexpresses CDR1 and CDR2; Hap43-repressed; flow model biofilm induced CAALFM_CR02820WA Ortholog of S. cerevisiae Pgm2; induced in planktonic culture; Tye7p-regulated; flow model biofilm induced; rat catheter biofilm repressed CAALFM_CR02850CA GATA-type transcription factor; oxidative stress-induced via Cap1; mutant has abnormal colony morphology and altered sensitivity to fluconazole, LiCl, and copper; Spider biofilm induced CAALFM_CR02860WA Small GTPase of Rho family; regulates beta-1,3-glucan synthesis activity and binds Gsc1p; essential; expected to be geranylgeranylated by geranylgeranyltransferase type I; plasma membrane-localized CAALFM_CR02870WA Predicted gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; that binds clathrin and is involved in vesicle mediated transport; induced in core caspofungin response; rat catheter biofilm repressed CAALFM_CR02880WA Protein of unknown function; Hap43-repressed; induced in core caspofungin response; regulated by yeast-hypha switch; Spider biofilm repressed CAALFM_CR02890CA Ortholog(s) have RNA polymerase III activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex, mitotic spindle pole body localization CAALFM_CR02910WA Predicted regulatory subunit of the Atg1 signaling complex; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; Spider biofilm induced CAALFM_CR02920CA Aquaporin water channel; osmotic shock resistance, WT freeze tolerance; virulent in mice; flucytosine repressed; flow model/RPMI/Spider/rat catheter biofilm induced; required for RPMI biofilm formation; Bcr1-induced in a/a RPMI biofilms CAALFM_CR02930WA Protein of unknown function; induced by nitric oxide independent of Yhb1p CAALFM_CR02940CA Putative ornithine transport protein; localized to the mitochondrial membrane CAALFM_CR02950CA Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translational initiation and mitochondrial small ribosomal subunit localization CAALFM_CR02960WA Protein of unknown function; rat catheter biofilm induced CAALFM_CR02970CA Ortholog(s) have ATP-dependent DNA helicase activity, DNA translocase activity CAALFM_CR02980CA Putative chaperone of small nucleolar ribonucleoprotein particles; macrophage/pseudohyphal-induced; rat catheter biofilm induced CAALFM_CR02990CA Putative GTP cyclohydrolase II; enzyme of riboflavin biosynthesis; fungal-specific (no human or murine homolog); regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_CR03000CA Ortholog of C. dubliniensis CD36 : Cd36_28090, C. parapsilosis CDC317 : CPAR2_802560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104949 and Debaryomyces hansenii CBS767 : DEHA2A12848g CAALFM_CR03010CA Predicted component of the mitochondrial intermembrane space (IMS), involved in protein import into mitochondrial intermembrane space CAALFM_CR03020CA Predicted HD domain metal dependent phosphohydrolase; Spider biofilm repressed CAALFM_CR03030CA Putative ribosomal protein; Plc1-regulated; downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_CR03040CA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose CAALFM_CR03050CA Zn(II)2Cys6 transcription factor; required for wild-type filamentous growth; mRNA binds She3 CAALFM_CR03060WA Putative G4 nucleic acid binding protein; macrophage/pseudohyphal-repressed; protein enriched in stationary phase yeast-form cultures; Spider biofilm repressed CAALFM_CR03070WA Ortholog of S. cerevisiae Dom34; a protein that facilitates ribosomal subunit dissociation when translation is stalled; peloto ortholog; Hap43-repressed gene CAALFM_CR03080CA Ortholog of C. dubliniensis CD36 : Cd36_28190, C. parapsilosis CDC317 : CPAR2_802530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_109615 and Debaryomyces hansenii CBS767 : DEHA2A12650g CAALFM_CR03090CA Microtubule-dependent localized protein; at Spitzenkorper and cytokinetic ring in hyphae; cell-cycle dependent localization to tip polarisome, bud neck in yeast and pseudohyphae; sumoylation target; rat catheter, Spider biofilm repressed CAALFM_CR03100WA Protein similar to S. cerevisiae Smc5p, which is involved in DNA repair; transposon mutation affects filamentous growth CAALFM_CR03110WA Ortholog(s) have role in mitochondrial translation and mitochondrion localization CAALFM_CR03120WA Ortholog of S. cerevisiae Mpm1; a mitochondrial intermembrane space protein of unknown function; Hap43-repressed; Spider biofilm induced CAALFM_CR03130WA Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway and Vps55/Vps68 complex, late endosome localization CAALFM_CR03140CA Putative endosomal SNARE; role in protein transport; rat catheter and Spider biofilm induced CAALFM_CR03150WA Protein similar to S. cerevisiae Sys3p; putative role in endosome-Golgi vesicle docking; upregulated in biofilm; induced upon adherence to polystyrene CAALFM_CR03160WA Ortholog(s) have tRNA methyltransferase activity, role in tRNA methylation, wybutosine biosynthetic process and cytosol, nucleus localization CAALFM_CR03170WA Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures CAALFM_CR03180WA Ortholog(s) have GTP binding, GTPase activity CAALFM_CR03200CA Ortholog(s) have RNA binding, ribonuclease MRP activity, ribonuclease P activity CAALFM_CR03210CA Ortholog(s) have CTD phosphatase activity, protein tyrosine phosphatase activity CAALFM_CR03220CA Ortholog(s) have cysteine-type endopeptidase activity CAALFM_CR03230WA Ortholog(s) have role in mRNA splicing, via spliceosome, maturation of SSU-rRNA, positive regulation of ATPase activity, positive regulation of helicase activity CAALFM_CR03240CA Putative transcription factor with zinc finger DNA-binding motif; similar to bacterial DnaJ; induced in low iron CAALFM_CR03250CA Protein of unknown function; Hap43-repressed; transcript increased in azole-resistant strain overexpressing CDR1 and CDR2; possibly regulated by Tac1; induced by Mnl1 in weak acid stress; flow model biofilm induced; Spider biofilm induced CAALFM_CR03260WA Putative aminotransferase; Hap43-repressed; homozygous Tn insertion decreases colony wrinkling in filament-inducing conditions, does not block true hypha formation in liquid media; rat catheter and Spider biofilm induced CAALFM_CR03270WA Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); amphotericin B, caspofungin repressed; Hap43p-repressed CAALFM_CR03280WA Zinc-binding dehydrogenase; induced by benomyl, ciclopirox olamine, alpha pheromone, Hap43; regulated by oxidative stress via Cap1, osmotic stress via Hog1; protein present in exponential and stationary phase; rat catheter biofilm repressed CAALFM_CR03290CA Putative serine/threonine protein kinase; mutation confers hypersensitivity to amphotericin B CAALFM_CR03300CA Ortholog(s) have aldehyde dehydrogenase (NAD) activity, role in response to furfural and cytoplasm, nucleus localization CAALFM_CR03310CA Putative transcription factor with zinc finger DNA-binding motif CAALFM_CR03320CA Ortholog of C. dubliniensis CD36 : Cd36_28460, Debaryomyces hansenii CBS767 : DEHA2B00704g, Pichia stipitis Pignal : PICST_43964 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00057 CAALFM_CR03330WA Putative protein of unknown function; Hap43p-repressed gene; S. cerevisiae ortholog YKR023W localizes to mitochondria CAALFM_CR03340CA Ortholog(s) have DNA replication origin binding, single-stranded DNA binding activity CAALFM_CR03350CA Putative tRNA-Pro synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage CAALFM_CR03360WA Ortholog(s) have role in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more CAALFM_CR03370CA Protein similar to S. cerevisiae Kti12p, which associates with Elongator complex; has a role in resistance to killer toxin; predicted Kex2p substrate; Hap43p-induced gene CAALFM_CR03380WA Putative mitochondrial GTPase; likely essential for respiratory competence and in large ribosomal subunit assembly; mitochondrial translation; Spider biofilm induced CAALFM_CR03390CA Yku70p-Yku80p Ku complex subunit involved in nonhomologous end joining during double-strand break repair repair; Hap43-repressed gene; flow model biofilm induced CAALFM_CR03400WA Protein similar to isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase is the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin CAALFM_CR03410WA Protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR03420CA Putative E3 ubiquitin-protein ligase; required for maintenance, but not induction, of hyphal development; homozygous null mutant is avirulent in mouse systemic infection despite persistence in host; repressed in rat oral candidiasis CAALFM_CR03430WA Ortholog(s) have role in syncytium formation by plasma membrane fusion, vacuolar proton-transporting V-type ATPase complex assembly and integral component of endoplasmic reticulum membrane localization CAALFM_CR03440WA Ortholog(s) have DNA 5'-adenosine monophosphate hydrolase activity, mismatched DNA binding, single-strand break-containing DNA binding, single-stranded DNA binding, zinc ion binding activity and cytosol, nucleus localization CAALFM_CR03450WA Putative sugar transporter; induced by ciclopirox olamine; Snf3-induced; alkaline repressed; colony morphology-related gene regulation by Ssn6; possibly essential gene CAALFM_CR03460WA Protein with a histone fold domain; similar to TAFII47 proteins from S. cerevisiae, Danio rerio, Drosophila melanogaster, human, and mouse CAALFM_CR03470WA Protein of unknown function; repressed by alpha pheromone in SpiderM medium; transcript induced by Mnl1 under weak acid stress CAALFM_CR03480WA Ortholog of C. dubliniensis CD36 : Cd36_28730, Candida tropicalis MYA-3404 : CTRG_00749 and Candida albicans WO-1 : CAWG_01683 CAALFM_CR03490WA Putative mitochondrial exonuclease; alpha-factor induced CAALFM_CR03500WA Citrate synthase; induced by phagocytosis; induced in high iron; Hog1-repressed; Efg1-regulated under yeast, not hyphal growth conditions; present in exponential and stationary phase; Spider biofilm repressed; rat catheter biofilm induced CAALFM_CR03510WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_CR03520CA Putative actin cytoskeleton component; protein present in exponential and stationary growth phase yeast cultures CAALFM_CR03530WA Mitochondrial inner membrane protein; mammalian mitofilin domain; Spider biofilm repressed CAALFM_CR03540WA Protein of unknown function; rat catheter biofilm induced CAALFM_CR03550WA Putative cytosolic thiouridylase subunit; Spider biofilm induced CAALFM_CR03560WA Has domain(s) with predicted role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of mitotic metaphase/anaphase transition and anaphase-promoting complex localization CAALFM_CR03570CA Putative dual specificity phosphatase (phosphoserine/threonine and phosphotyrosine phosphatase); required for wild-type growth rate and for wild-type virulence in mouse model of systemic infection; Hap43p-induced gene CAALFM_CR03580CA Putative MFS transporter; predicted ORF in Assembly 20; removed from Assembly 21; restored based on conservation among several Candida species CAALFM_CR03590CA Ortholog(s) have DNA 5'-adenosine monophosphate hydrolase activity, mismatched DNA binding, single-strand break-containing DNA binding, single-stranded DNA binding, zinc ion binding activity CAALFM_CR03600CA Ortholog(s) have role in retrograde vesicle-mediated transport, Golgi to ER and COPI vesicle coat, cytosol, nucleus localization CAALFM_CR03610CA Putative polyphosphate synthetase; downregulated in core caspofungin response; Hog1p-induced; transcription is opaque-specific; fungal-specific (no human or murine homolog) CAALFM_CR03620CA Ortholog(s) have role in mitochondrial genome maintenance and integral component of mitochondrial inner membrane localization CAALFM_CR03630WA Putative GPI-anchored protein CAALFM_CR03640CA Ortholog(s) have role in protein targeting to mitochondrion and mitochondrial outer membrane, peroxisomal membrane localization CAALFM_CR03650WA Predicted small ribosomal subunit biogenesis protein; repressed in core stress response; transcript increases in populations of cells exposed to fluconazole over multiple generations; Spider biofilm induced CAALFM_CR03660CA Has domain(s) with predicted RNA methyltransferase activity and role in RNA processing CAALFM_CR03670WA Ortholog of C. dubliniensis CD36 : Cd36_28870, Candida tropicalis MYA-3404 : CTRG_00731 and Candida albicans WO-1 : CAWG_01703 CAALFM_CR03680CA Protein similar to chromosomal ATPases; RNA abundance regulated by tyrosol and cell density; cell-cycle regulated periodic mRNA expression CAALFM_CR03690WA Has domain(s) with predicted hydrolase activity and role in cellular process CAALFM_CR03700CA Ortholog of S. cerevisiae Spp41; protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 in S. cerevisiae; mutants are viable CAALFM_CR03710CA Protein of unknown function; induced by nitric oxide; oxidative stress-induced via Cap1; fungal-specific (no human or murine homolog) CAALFM_CR03720WA Transaldolase; protein present in exponential and stationary growth phase yeast cultures; oxidative stress-induced via Cap1; induced by nitric oxide independent of Yhb1p; sumoylation target; rat catheter biofilm repressed CAALFM_CR03730CA Predicted transmembrane transporter; rat catheter and Spider biofilm induced CAALFM_CR03740CA Protein similar to S. cerevisiae Fmn1p, which is riboflavin kinase; predicted Kex2p substrate; Hap43p-repressed gene CAALFM_CR03750CA Putative component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae PRP42 CAALFM_CR03760WA Ortholog(s) have N-terminal protein N-methyltransferase activity, protein-lysine N-methyltransferase activity and role in N-terminal peptidyl-glycine methylation, chromatin silencing at rDNA, peptidyl-lysine dimethylation CAALFM_CR03770CA Putative 40S ribosomal protein S30; colony morphology-related gene regulation by Ssn6; rat catheter biofilm repressed CAALFM_CR03780CA Protein of unknown function; Spider biofilm induced CAALFM_CR03790CA Cell wall glycoprotein; beta glucan synthesis; increases glucan content in S. cerevisiae kre1, complements killer toxin sensitivity; caspofungin induced; Spider/rat catheter/flow model biofilm induced; Bcr1-repressed in RPMI a/a biofilms CAALFM_CR03800CA Putative catalytic subunit of protein phosphatase complex; functions with regulatory subunit Psy2p in dephosphorylation of Rad53p in response to DNA damage; dephosphorylates Rfa2p in G1 phase; ortholog of S. cerevisiae Pph3p CAALFM_CR03810WA Putative integral inner mitochondrial membrane protein with similarity to exonucleases CAALFM_CR03820CA SUMO deconjugation enzyme; removes the small ubiquitin-like modifier (SUMO) from proteins; Spider biofilm induced CAALFM_CR03830CA Phosphorylated protein of unknown function; transcription is periodic with a peak at M/G1 phase of the cell cycle CAALFM_CR03840CA Ortholog of C. dubliniensis CD36 : Cd36_29080, C. parapsilosis CDC317 : CPAR2_202490, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112323 and Debaryomyces hansenii CBS767 : DEHA2F19184g CAALFM_CR03850WA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended C terminus; expressed in rich medium with 2% glucose CAALFM_CR03860CA Putative protein similar to S. cerevisiae Mgr3p, a subunit of the i-AAA protease supercomplex that degrades misfolded mitochondrial proteins CAALFM_CR03870WA Putative protein of unknown function; Hap43p-repressed gene; S. cerevisiae ortholog YDL157C localizes to mitochondria CAALFM_CR03880WA Predicted GPI-linked cell-wall protein; similar to Hyr1; induced in low iron; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR03890WA Transcription factor; modulator of white-opaque switch; induced in opaque cells; promoter bound by Wor1; overexpression at 25 degr shifts cells to opaque state; deletion stabilizes opaque cells at higher temperatures; Spider biofilm induced CAALFM_CR03900WA MAP kinase kinase involved in mating and hyphal growth signal transduction pathways; phosphorylates Cek1p; wild-type virulence in mouse systemic infection; functional homolog of S. cerevisiae Ste7p; mutants are hypersensitive to caspofungin CAALFM_CR03910CA Ortholog(s) have RNA polymerase II activating transcription factor binding, TBP-class protein binding, chromatin binding, protein complex scaffold activity CAALFM_CR03920CA Putative sperimidine transporter; fungal-specific (no human or murine homolog); Spider biofilm induced; promoter bound by Tec1 and Ndt80; Bcr1-repressed in RPMI a/a biofilms CAALFM_CR03930CA Ortholog(s) have role in mRNA export from nucleus, nuclear envelope organization, protein export from nucleus and endoplasmic reticulum, nuclear envelope localization CAALFM_CR03940WA Putative rRNA processing protein; rat catheter biofilm induced CAALFM_CR03950WA Ortholog(s) have role in mitochondrial translation and mitochondrion localization CAALFM_CR03960CA Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; plays a role in autophagy, protein targeting to vacuole and vesicle docking; flow model biofilm induced CAALFM_CR03970CA Ortholog(s) have SNAP receptor activity and role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER, vesicle fusion with Golgi apparatus CAALFM_CR03980WA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_CR03990CA Putative translation initiation factor; transcript regulated by Mig1; repressed upon phagocytosis by murine macrophage CAALFM_CR04000WA 26S proteasome regulatory subunit; regulated by Gcn2p and Gcn4p; protein level decreases in stationary phase cultures CAALFM_CR04010CA Putative mitochondrial ribosomal protein; Spider biofilm repressed CAALFM_CR04020CA Ortholog(s) have structural constituent of cytoskeleton activity CAALFM_CR04030WA p150 subunit of dynactin; required for normal spindle formation and position CAALFM_CR04040CA Putative DNA-binding transcription factor; predicted role in regulation of biogenesis of the cell wall; upregulated in biofilm; protein newly produced during adaptation to the serum CAALFM_CR04050CA Nuclear export protein; has NTF2-like domain; interacts with Mtr2p via the NTF2-like domain CAALFM_CR04060CA Similar to mammalian membrane-associated progesterone receptors involved in DNA damage response; induced in core stress response; Hog1 regulated; clade-associated expression; Hap43-repressed CAALFM_CR04070WA Subunit of the N-terminal acetyltransferase NatA; Spider biofilm repressed CAALFM_CR04080CA Endoplasmic reticulum (ER) protein-translocation complex subunit CAALFM_CR04090CA 5-Aminoimidazole-4-carboxamide ribotide transformylase, enzyme of adenine biosynthesis; antigenic in human; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog CAALFM_CR04100CA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed CAALFM_CR04110WA Putative RNA-binding protein; role in assembly of box H/ACA snoRNPs and thus pre-rRNA processing; Spider biofilm induced CAALFM_CR04120CA Ortholog(s) have DNA-dependent ATPase activity, dinucleotide insertion or deletion binding, guanine/thymine mispair binding activity, role in mismatch repair, mitochondrial DNA repair and mitochondrion localization CAALFM_CR04130CA Subunit of the NuA4 histone acetyltransferase complex CAALFM_CR04140WA Putative mitochondrial ribosomal component of the small subunit; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed CAALFM_CR04150WA Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in translational readthrough and mitochondrion localization CAALFM_CR04160CA Ortholog(s) have tRNA (adenine-N1-)-methyltransferase activity, role in tRNA methylation and nucleus, tRNA (m1A) methyltransferase complex localization CAALFM_CR04170WA Ortholog(s) have rRNA (cytosine-C5-)-methyltransferase activity and role in assembly of large subunit precursor of preribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA base methylation CAALFM_CR04180CA Ortholog(s) have ATP-dependent 3'-5' DNA helicase activity, role in nucleosome mobilization and Ino80 complex localization CAALFM_CR04190WA Adenylate cyclase-associated protein; regulates adenylate cyclase activity; required for wild-type germ tube formation and for virulence in mice; mutant defects in filamentous growth are rescued by cAMP or dbcAMP; Spider biofilm repressed CAALFM_CR04200WA Putative type I HSP40 co-chaperone; heavy metal (cadmium) stress-induced CAALFM_CR04210CA Putative antibiotic resistance transporter; regulated by white-opaque switch, Nrg1, Tup1; Hap43, caspofungin repressed; repressed during chlamydospore formation; flow model biofilm induced; Spider biofilm repressed CAALFM_CR04220CA Protein of unknown function; Spider biofilm induced CAALFM_CR04230WA Ortholog(s) have ribosylnicotinamide kinase activity, role in NAD biosynthesis via nicotinamide riboside salvage pathway, nicotinamide riboside metabolic process and cytoplasm localization CAALFM_CR04240CA Ortholog of S. cerevisiae Kre33; essential; S. cerevisiae ortholog is essential and is required for biogenesis of the small ribosomal subunit CAALFM_CR04250WA Protein with a DNA-binding domain, similar to S. cerevisiae meiosis-specific transcription factor Ndt80p CAALFM_CR04260WA Putative U6 snRNA-associated protein; transcript regulated by Mig1 CAALFM_CR04270CA Has domain(s) with predicted nucleic acid binding, zinc ion binding activity CAALFM_CR04280CA S. cerevisiae ortholog Rft1p has role in glycolipid translocation, protein N-linked glycosylation and localizes to endoplasmic reticulum membrane; regulated by Sef1p-, Sfu1p-, and Hap43p CAALFM_CR04290WA Putative CCAAT-binding transcription factor; regulates CYC1; required for resistance to rapamycin, copper; induced in high iron; repressed in low iron; Sef1, Sfu1, and Hap43 regulated; rat catheter and Spider biofilm induced CAALFM_CR04300WA Ortholog(s) have tRNA (cytosine-5-)-methyltransferase activity, tRNA binding activity, role in cellular response to hydrogen peroxide, wobble base cytosine methylation and nucleus localization CAALFM_CR04310CA Ortholog(s) have RNA polymerase I upstream control element sequence-specific DNA binding, transcription factor activity, RNA polymerase I upstream control element sequence-specific binding activity CAALFM_CR04330WA Ortholog of C. dubliniensis CD36 : Cd36_29660, C. parapsilosis CDC317 : CPAR2_205200, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96118 and Debaryomyces hansenii CBS767 : DEHA2F21428g CAALFM_CR04340WA ATP-dependent Lon protease; role in degradation of misfolded proteins in mitochondria, biogenesis and maintenance of mitochondria; rat catheter biofilm induced CAALFM_CR04350CA Ortholog(s) have role in mitotic sister chromatid segregation and cytosol, nucleus localization CAALFM_CR04360CA Putative H/ACA snoRNP protein; macrophage/pseudohyphal-induced CAALFM_CR04370WA Protein of unknown function; flow model biofilm induced CAALFM_CR04380CA Secretory vesicles coatomer complex protein CAALFM_CR04390CA Ortholog of C. dubliniensis CD36 : Cd36_29750, C. parapsilosis CDC317 : CPAR2_205260, Candida tenuis NRRL Y-1498 : CANTEDRAFT_91782 and Debaryomyces hansenii CBS767 : DEHA2F19294g CAALFM_CR04400WA Protein of unknown function CAALFM_CR04410WA Protein with a UV radiation resistance protein/autophagy-related protein 14 domain; Hap43p-induced gene; mutants are viable CAALFM_CR04420CA Cell wall protein; expression repressed by Rim101; transcript regulated upon white-opaque switching; repressed by alpha pheromone in SpiderM medium; macrophage-induced gene CAALFM_CR04440CA Glycosylphosphatidylinositol (GPI)-anchored cell wall protein; required for filamentous growth at acidic pH; expression repressed by Rim101 and activated by Nrg1; Hap43-induced CAALFM_CR04450CA Ortholog(s) have chromatin binding, protein complex scaffold, ubiquitin binding activity and role in histone acetylation, transcription from RNA polymerase II promoter CAALFM_CR04460CA Ortholog of C. dubliniensis CD36 : Cd36_29810, C. parapsilosis CDC317 : CPAR2_206030, Candida tenuis NRRL Y-1498 : CANTEDRAFT_102086 and Debaryomyces hansenii CBS767 : DEHA2F14014g CAALFM_CR04470WA Subunit of the GPI-N-acetylglucosaminyl transferase (GPI-GnT) that catalyzes the first step in GPI anchor biosynthesis CAALFM_CR04480CA Putative aminopeptidase; positively regulated by Sfu1; clade-associated gene expression; virulence-group-correlated expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider and flow model biofilm induced CAALFM_CR04490CA Has domain(s) with predicted palmitoyl-(protein) hydrolase activity and role in cellular protein modification process CAALFM_CR04500CA Has domain(s) with predicted oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors activity CAALFM_CR04510WA Hexokinase II; antigenic in humans; repressed by human neutrophils; Efg1-regulated; fluconazole-induced; gene regulation by Ssn6; present in exponential and stationary growth phase; flow model biofilm induced; Spider biofilm repressed CAALFM_CR04520WA Predicted mitochondrial protein involved in outer membrane protein import; rat catheter biofilm repressed CAALFM_CR04530WA Fumarate hydratase; induced in high iron; protein in exponential and stationary-phase yeast cells, but higher in stationary phase; rat catheter biofilm repressed CAALFM_CR04540CA Ortholog(s) have ribonuclease P activity, role in intronic box C/D snoRNA processing, tRNA processing and cytosol, nucleolar ribonuclease P complex localization CAALFM_CR04550WA Putative alpha-4 subunit of the proteasome; reported as macrophage-induced protein and macrophage/pseudohyphal-repressed gene; regulated by Gcn2p and Gcn4p; removed from/reinstated in Assembly 20 (see Locus History) CAALFM_CR04560CA Ortholog(s) have 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair, 5'-flap endonuclease activity, double-stranded DNA 5'-3' exodeoxyribonuclease activity, single-stranded DNA 5'-3' exodeoxyribonuclease activity CAALFM_CR04570CA Septin, required for wild-type cell, hyphal, or chlamydospore morphology; role in virulence and kidney tissue invasion in mouse infection; forms ring at sites of cell division and filaments in mature chlamydospore; Spider biofilm repressed CAALFM_CR04580WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial inner membrane, mitochondrial large ribosomal subunit localization CAALFM_CR04590CA Pyridoxamine-phosphate oxidase; transcript regulated by yeast-hypha switch and by Nrg1, Mig1, Tup1; Hap43, caspofungin repressed; present in exponential and stationary phase yeast cultures CAALFM_CR04600WA Ortholog of C. dubliniensis CD36 : Cd36_29980, C. parapsilosis CDC317 : CPAR2_204170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_110235 and Debaryomyces hansenii CBS767 : DEHA2F17072g CAALFM_CR04610CA Ortholog of a S. cerevisiae Atg22; a vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR04620CA Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) CAALFM_CR04630CA Monooxygenase of the cytochrome P450 family; produces N,N'-bisformyl dityrosine from N-formyltyrosine; regulated by Nrg1, Mig1, and Tup1; role in chlamydospore formation; Spider biofilm induced CAALFM_CR04640WA Ortholog(s) have catalytic activity and role in ascospore wall assembly CAALFM_CR04650WA Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; possibly involved the beta-tubulin folding; Spider biofilm repressed CAALFM_CR04660CA UTP-glucose-1-phosphaturidyl transferase; localizes to yeast, not hyphal cell surface; Hog1-repressed; stationary phase enriched; induced in oralpharyngeal candidasis; rat catheter biofilm repressed; Bcr1-repressed in RPMI a/a biofilms CAALFM_CR04680CA Protein of unknown function; transcript detected on high-resolution tiling arrays CAALFM_CR04710WA Ortholog(s) have U2-type spliceosomal complex localization CAALFM_CR04720CA Putative ATPase and nucleosome spacing factor; heterozygous null mutant displays sensitivity to virgineone CAALFM_CR04730WA Ortholog(s) have endoplasmic reticulum, mitochondrion localization CAALFM_CR04740CA 5-Phosphoribosylformyl glycinamidine synthetase; adenine biosynthesis; not induced in GCN response, in contrast to S. cerevisiae Ade6; protein in stationary phase yeast-form cultures; flow model and rat catheter biofilm repressed CAALFM_CR04750WA Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_CR04760CA Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS) CAALFM_CR04770CA Ortholog of C. dubliniensis CD36 : Cd36_30140, C. parapsilosis CDC317 : CPAR2_204040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114703 and Debaryomyces hansenii CBS767 : DEHA2G22880g CAALFM_CR04780WA Putative subunit of RNA polymerases I, II, and III; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); heterozygous null mutant exhibits resistance to parnafungin CAALFM_CR04790WA ESCRT-I complex subunit with a role in multivesicular body (MVB) trafficking; mutant displays growth defect on alkaline medium; Hap43p-repressed gene CAALFM_CR04800WA Predicted alpha-1,3-mannosyltransferase with a role in protein glycosylation; induced in low iron CAALFM_CR04810WA Ribosomal protein S3; Hog1, Hap43-induced; grepressed upon phagocytosis by murine macrophage; present in exponential and stationary phase cells; Spider biofilm repressed CAALFM_CR04820WA Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_CR04830CA Has domain(s) with predicted myosin binding activity CAALFM_CR04840CA Transcription factor; activator that binds to Flo8 via a LisH motif to cooperatively activate transcription of hypha-specific genes; required for hyphal growth CAALFM_CR04850CA Ortholog of Candida albicans WO-1 : CAWG_01818 CAALFM_CR04860CA Ortholog of C. dubliniensis CD36 : Cd36_30250, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98619, Debaryomyces hansenii CBS767 : DEHA2G22594g and Pichia stipitis Pignal : PICST_50168 CAALFM_CR04870CA Trimethylaminobutyraldehyde dehydrogenase, the third enzyme of the carnitine biosynthesis pathway CAALFM_CR04880WA Hydroxytrimethyllysine aldolase, the second enzyme in the carnitine biosynthesis pathway; rat catheter biofilm repressed CAALFM_CR04890WA Phosphopantetheinyl transferase; enzyme of lysine biosynthesis; modifies, and thereby activates, Lys2p alpha-aminoadipate reductase; functional homolog of S. cerevisiae Lys5p CAALFM_CR04900CA Putative GPI-anchored protein CAALFM_CR04910WA Beta subunit of heterodimeric protein geranylgeranyltransferase type I; GGTase I enzyme binds zinc, is Mg-dependent; Cdc42p is GGTase I substrate CAALFM_CR04920WA Ortholog(s) have mitochondrion localization CAALFM_CR04930WA Ortholog(s) have peroxisome matrix targeting signal-1 binding, peroxisome matrix targeting signal-2 binding, protein binding, bridging activity CAALFM_CR04940WA Ortholog of C. dubliniensis CD36 : Cd36_30340, C. parapsilosis CDC317 : CPAR2_203900, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113094 and Debaryomyces hansenii CBS767 : DEHA2G22374g CAALFM_CR04950WA RNA polymerase II mediator complex subunit; transcription positively regulated by Tbf1p CAALFM_CR04960CA Methyltransferase involved in sphingolipid homeostasis, methylates a drug cantharidin; decreased expression in hyphae compared to yeast; expression regulated during planktonic growth; flow model biofilm induced; Hap43-repressed gene CAALFM_CR04970CA Ortholog of C. dubliniensis CD36 : Cd36_30370, Candida tropicalis MYA-3404 : CTRG_00536 and Candida albicans WO-1 : CAWG_01831 CAALFM_CR04980CA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_CR04990CA Predicted protein only found in C. albicans and C. dubliniensis; highly induced during chlamydospore development CAALFM_CR05010WA Ortholog(s) have crossover junction endodeoxyribonuclease activity, role in DNA repair and cytoplasm, nucleus localization CAALFM_CR05020WA Putative permease; amphotericin B induced; flucytosine repressed; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR05030WA Ortholog of C. dubliniensis CD36 : Cd36_30530, C. parapsilosis CDC317 : CPAR2_203340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117008 and Debaryomyces hansenii CBS767 : DEHA2G24244g CAALFM_CR05050WA Putative glutamate synthase; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider biofilm induced CAALFM_CR05080WA Predicted proton-transporting ATPase; predicted role in ATP hydrolysis coupled proton transport; rat catheter biofilm repressed CAALFM_CR05090CA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media; intron CAALFM_CR05100WA Ortholog(s) have role in apoptotic process, mitotic spindle assembly checkpoint, mitotic spindle elongation, sister chromatid biorientation CAALFM_CR05120WA Ortholog of C. dubliniensis CD36 : Cd36_30470, C. parapsilosis CDC317 : CPAR2_203380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117493 and Debaryomyces hansenii CBS767 : DEHA2G19228g CAALFM_CR05130CA Ortholog(s) have role in protein folding and endoplasmic reticulum localization CAALFM_CR05140WA Integral membrane protein of the ER; role in the synthesis of beta-1,6-glucan in the cell wall; S. cerevisiae ortholog required for cell viability; Spider biofilm induced CAALFM_CR05150WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization CAALFM_CR05160CA S. cerevisiae ortholog YDR370C/DXO1 has decapping and 5'-3' exoRNase activity; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 CAALFM_CR05170CA Formate dehydrogenase; oxidizes formate to CO2; Mig1 regulated; induced by macrophages; fluconazole-repressed; repressed by Efg1 in yeast, not hyphal conditions; stationary phase enriched; rat catheter and Spider biofilm induced CAALFM_CR05180CA Succinate dehydrogenase, Fe-S subunit; localizes to surface of yeast cells, but not hyphae; induced in high iron and during log phase aerobic growth; repressed by nitric oxide, Hap43 CAALFM_CR05190WA Protein similar to S. cerevisiae Cis3p, which has a role cell-wall-related processes; predicted Kex2p substrate; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR05200CA Protein of unknown function; regulated by Ssn6 CAALFM_CR05210WA Protein of unknown function; Hap43-repressed; Spider biofilm repressed CAALFM_CR05220CA Putative glycerol kinase; downregulated upon adherence to polystyrene; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type CAALFM_CR05240CA Protein encoded in retrotransposon Zorro3 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_CR05250CA Protein encoded in retrotransposon Zorro3 with a potential zinc finger; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_CR05260CA Putative bZIP transcription factor; Spider biofilm induced CAALFM_CR05290WA Mannosyltransferase; transcription elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog) CAALFM_CR05300CA Ortholog(s) have alpha-1,2-mannosyltransferase activity, role in cell wall mannoprotein biosynthetic process and Golgi apparatus localization CAALFM_CR05310WA Ortholog(s) have clathrin binding activity, role in Golgi to vacuole transport, endosomal transport and AP-1 adaptor complex, cytosol, endosome, nucleus localization CAALFM_CR05330WA Protein of unknown function; Spider biofilm repressed CAALFM_CR05340CA Putative alcohol dehydrogenase; yeast-enriched transcript; Efg1-regulated; induced by prostaglandins, Hog1, fluconazole; rat catheter biofilm induced CAALFM_CR05360CA Ortholog of C. dubliniensis CD36 : Cd36_30690, C. parapsilosis CDC317 : CPAR2_204140, Debaryomyces hansenii CBS767 : DEHA2F16940g and Candida tropicalis MYA-3404 : CTRG_00570 CAALFM_CR05380CA Putative flavodoxin; flow model, rat catheter and Spider biofilm repressed CAALFM_CR05390WA Putative flavodoxin; YNB biofilm induced; stationary phase enriched protein; rat catheter and Spider biofilm repressed CAALFM_CR05430WA Putative cell wall associated protein; gene only found in C. albicans and C. dubliniensis; highly upregulated during chlamydospore development in both species; localized to chlamydospore cell wall CAALFM_CR05440WA Putative 3-hydroxyanthranilic acid dioxygenase, involved in NAD biosynthesis; Hap43p-repressed gene CAALFM_CR05450CA Protein of unknown function; Hap43-repressed; Spider biofilm repressed CAALFM_CR05460WA Ortholog(s) have role in protein localization to Golgi apparatus, protein processing, regulation of protein glycosylation and Dsc E3 ubiquitin ligase complex, endoplasmic reticulum, fungal-type vacuole lumen localization CAALFM_CR05480WA Ortholog(s) have dicarboxylic acid transmembrane transporter activity, role in mitochondrial transport and mitochondrial inner membrane localization CAALFM_CR05490WA Predicted transcription factor; induced during planktonic growth, whereas related SUA71 is downregulated CAALFM_CR05500CA Protein of unknown function; rat catheter biofilm repressed CAALFM_CR05510WA Putative pheromone-processing dipeptidyl aminopeptidase; possible Kex2 substrate; transposon mutation affects filamentous growth; induced by low nitrogen, germ tube formation; flow model biofilm repressed CAALFM_CR05520WA Putative nucleolar complex protein; Hap43-induced; transposon mutation affects filamentous growth; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); repressed in core stress response CAALFM_CR05530CA Zn2Cys6 transcription factor involved in negative regulation of nitrosative stress response; mutant has cell wall defects; transcription increased at stationary phase; has predicted PAS domain; similar to S. cerevisiae Rds2p CAALFM_CR05540CA RING-type zinc finger protein; upregulated during oral infection; mutants have reduced ability to damage oral epithelial cells; Spider and flow model biofilm induced CAALFM_CR05550CA Ortholog(s) have RNA polymerase III activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex, cytosol localization CAALFM_CR05560WA Putative TFIIH and nucleotide excision repair factor 3 complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR05570CA Putative ribonucleotide reductase large subunit; transcript induced in low iron; rat catheter and Spider biofilm induced CAALFM_CR05580CA Ortholog(s) have role in meiotic DNA recombinase assembly, reciprocal meiotic recombination and condensed nuclear chromosome localization CAALFM_CR05610CA Two-component system response regulator; involved in stress response; Plc1-regulated; upregulated in cyr1 null mutant; flow model biofilm induced; Spider biofilm induced CAALFM_CR05620CA Putative Obg family GTPase member; peripheral protein of the mitochondrial inner membrane; associates with the large ribosomal subunit; required for mitochondrial translation; rat catheter biofilm repressed CAALFM_CR05630WA Protein similar to S. cerevisiae Dbp8p, an ATP-dependent helicase involved in rRNA processing; oxidative stress-repressed via Cap1p; flucytosine repressed; likely to be essential for growth, based on insertional mutagenesis CAALFM_CR05640CA Ortholog of C. dubliniensis CD36 : Cd36_30990, C. parapsilosis CDC317 : CPAR2_204660, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104939 and Debaryomyces hansenii CBS767 : DEHA2G23760g CAALFM_CR05650WA Component of the general transcription factor for RNA polymerase III (TFIIIB); possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR05660WA Predicted nuclear protein involved in actin cytoskeleton organization, passage through Start, 60S ribosome biogenesis; rat catheter biofilm induced; Hap43-induced CAALFM_CR05670CA HMG-box transcription factor; binds upstream of hexose and ergosterol metabolism and cell cycle genes; activates pseudohyphal growth when expressed in S. cerevisiae; repressed in hyphae; Spider biofilm repressed CAALFM_CR05680CA Protein of unknown function; 2 predicted transmembrane domains; transcript detected on high-resolution tiling arrays; flow model biofilm induced; Spider biofilm repressed CAALFM_CR05690WA Putative malonyl-CoA acyl carrier protein acyltransferase CAALFM_CR05700CA Ortholog(s) have role in ER to Golgi vesicle-mediated transport and ER to Golgi transport vesicle, endoplasmic reticulum membrane, integral component of Golgi membrane localization CAALFM_CR05710CA Ortholog of Candida albicans WO-1 : CAWG_01892 CAALFM_CR05720WA Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; induced in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; stationary phase enriched protein; Hap43-repressed CAALFM_CR05730CA Ortholog of S. cerevisiae Mdm36; mitochondrial distribution and morphology protein; Hap43-repressed gene CAALFM_CR05740CA Type PP2C serine/threonine phosphatase; localized to mitochondria; mutation causes sensitivity to sodium, potassium and azole drugs; decreased expression in hyphae compared to yeast-form cells CAALFM_CR05750WA Predicted glycosyl hydrolase; hypoxia induced; flow model biofilm induced CAALFM_CR05760CA Protein of unknown function; rat catheter biofilm repressed CAALFM_CR05770WA Ortholog of C. dubliniensis CD36 : Cd36_31170, C. parapsilosis CDC317 : CPAR2_205340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133521 and Debaryomyces hansenii CBS767 : DEHA2E21868g CAALFM_CR05780WA Vacuolar H(+)-ATPase; protein present in exponential and stationary growth phase yeast cultures; plasma membrane localized; amphotericin B repressed, caspofungin repressed CAALFM_CR05790CA Putative aconitate hydratase 2; induced in high iron; regulated by Gcn4; repressed by amino acid starvation (3-AT); protein levels decrease in stationary phase yeast; flow model and Spider biofilm repressed CAALFM_CR05800CA Ortholog(s) have role in ER-associated ubiquitin-dependent protein catabolic process CAALFM_CR05830CA Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; mutant is viable CAALFM_CR05840WA Protein of unknown function; rat catheter biofilm repressed CAALFM_CR05860WA Protein of unknown function; possibly transcriptionally regulated upon hyphal formation CAALFM_CR05880WA Predicted homeodomain-containing protein; possible transcription factor; possibly transcriptionally regulated upon hyphal formation CAALFM_CR05890CA Ortholog(s) have acetyltransferase activator activity, histone binding activity and role in double-strand break repair via nonhomologous end joining, nucleosome assembly, positive regulation of histone acetylation CAALFM_CR05900WA Ortholog(s) have GTPase activator activity and clathrin-coated vesicle, endosome, trans-Golgi network localization CAALFM_CR05910WA Ortholog(s) have RNA polymerase II core binding activity, role in chromatin-mediated maintenance of transcription, transcription elongation from RNA polymerase II promoter and transcription elongation factor complex localization CAALFM_CR05920CA Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; possibly transcriptionally regulated upon hyphal formation; possibly an essential gene (by UAU1 method) CAALFM_CR05940WA MAP kinase required for wild-type efficiency of mating; component of the signal transduction pathway that regulates mating; ortholog of S. cerevisiae Fus3; induced by Cph1, pheromone; transposon mutation affects filamentous growth CAALFM_CR05950CA Putative PDR-subfamily ABC transporter; similar to WHITE subfamily proteins; gene used for strain identification by multilocus sequence typing CAALFM_CR05960WA Ortholog of C. parapsilosis CDC317 : CPAR2_205150, Debaryomyces hansenii CBS767 : DEHA2G10538g, Pichia stipitis Pignal : psti_CGOB_00130 and Candida guilliermondii ATCC 6260 : PGUG_02975 CAALFM_CR05970CA Ortholog(s) have protein transmembrane transporter activity and role in chaperone-mediated protein complex assembly, mitochondrial respiratory chain complex III assembly, protein insertion into mitochondrial membrane from inner side CAALFM_CR05980WA Ortholog(s) have ubiquitin-specific protease activity and role in protein deubiquitination, ubiquitin homeostasis, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway CAALFM_CR05990CA Transcription factor involved in negative regulation of morphogenesis, flocculation and virulence; induced in core caspofungin response; Spider biofilm induced CAALFM_CR06000WA Protein kinase required for degradation of Nrg1p; mutants are sensitive to growth on hydrogen peroxide medium; induced by alpha pheromone in SpiderM medium; rat catheter and Spider biofilm induced CAALFM_CR06010WA Ortholog of C. dubliniensis CD36 : Cd36_31420, C. parapsilosis CDC317 : CPAR2_205100, Debaryomyces hansenii CBS767 : DEHA2G10648g and Pichia stipitis Pignal : PICST_32997 CAALFM_CR06020WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_CR06030CA Has domain(s) with predicted carbohydrate binding, catalytic activity and role in carbohydrate metabolic process CAALFM_CR06040WA Ortholog of S. cerevisiae Sat4; amphotericin B induced; clade-associated gene expression; Spider biofilm induced CAALFM_CR06050WA Cyclin-dependent protein kinase; interacts with regulatory subunit Cyb1; determination of cell morphology during the cell cycle; phosphorylated mostly by Swe1 and phosphorylation is regulated by Hsl1; 5'-UTR intron; Spider biofilm repressed CAALFM_CR06060WA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_CR06070WA Putative microsomal beta-keto-reductase; transcript upregulated by treatment with ciclopirox olamine; induced by alpha pheromone in SpiderM medium; regulated by Sef1, Sfu1, and Hap43 CAALFM_CR06080WA Putative Type II HSP40 co-chaperone; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm induced CAALFM_CR06090WA Putative intracellular transport protein; heterozygous null mutant displays sensitivity to rapamycin; expression upregulated during growth in the mouse cecum CAALFM_CR06100CA Ortholog of C. dubliniensis CD36 : Cd36_31580, C. parapsilosis CDC317 : CPAR2_205000, Debaryomyces hansenii CBS767 : DEHA2G10846g and Pichia stipitis Pignal : PICST_32988 CAALFM_CR06110CA Transcription factor; involved in DNA damage responses, morphogenesis, and virulence; Spider biofilm induced CAALFM_CR06120WA Ribosomal protein L7; repressed upon phagocytosis by murine macrophages; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_CR06140WA Protein of unknown function; regulated by Tsa1, Tsa1B in minimal media at 37 degrees C; shows colony morphology-related gene regulation by Ssn6; Spider biofilm induced CAALFM_CR06150CA Adenylosuccinate lyase; enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide CAALFM_CR06160CA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_CR06170WA Protein of unknown function; oral infection induced; mutants have reduced capacity to damage oral epithelial cells; rat catheter biofilm repressed CAALFM_CR06180WA Protein similar to S. cerevisiae Arc40; involved in actin filament organization in S. cerevisiae; transposon mutation affects filamentous growth; rat catheter and Spider biofilm repressed CAALFM_CR06230WA Predicted cation transmembrane transporter; Spider biofilm induced CAALFM_CR06240CA Predicted Zn(II)2Cys6 transcription factor CAALFM_CR06250WA Ortholog of C. dubliniensis CD36 : Cd36_73360 and Candida albicans WO-1 : CAWG_01936 CAALFM_CR06260WA Protein of unknown function; flow model biofilm induced CAALFM_CR06270WA Predicted protein of unknown funtion; overlaps orf19.3879.1, which is a region annotated as blocked reading frame CAALFM_CR06290CA Ortholog of C. dubliniensis CD36 : Cd36_31790, C. parapsilosis CDC317 : CPAR2_204900, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136864 and Debaryomyces hansenii CBS767 : DEHA2F13200g CAALFM_CR06300CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Spider biofilm repressed CAALFM_CR06310WA Has domain(s) with predicted N-acetyltransferase activity; highly induced during chlamydospore formation in both C. albicans and C. dubliniensis CAALFM_CR06320CA Ortholog of C. dubliniensis CD36 : Cd36_31820, C. parapsilosis CDC317 : CPAR2_205050, Debaryomyces hansenii CBS767 : DEHA2G10736g and Pichia stipitis Pignal : PICST_32993 CAALFM_CR06330CA Ortholog(s) have cytoplasm, nucleus localization CAALFM_CR06340CA Glucose-6-phosphate isomerase; enzyme of glycolysis; antigenic; Efg1-regulated; induced upon adherence to polystyrene; repressed by phagocytosis, human neutrophils; flow model biofilm induced; rat catheter and Spider biofilm repressed CAALFM_CR06380CA Predicted ORF overlapping the Major Repeat Sequence on chromosome R; member of a family encoded by FGR6-related genes in the RB2 repeat sequence CAALFM_CR06420WA Protein phosphatase Z; type 1 family serine/threonine specific protein phosphatase involved in cation homeostasis and cell wall integrity CAALFM_CR06430WA Ortholog of C. dubliniensis CD36 : Cd36_31880, C. parapsilosis CDC317 : CPAR2_702220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115848 and Debaryomyces hansenii CBS767 : DEHA2E06028g CAALFM_CR06440CA Transcription factor; regulates a/alpha biofilm formation, matrix, cell-surface-associated genes; confers adherence, impermeability, impenetrability, fluconazole resistance; Tup1/Tec1/Mnl1-regulated; mRNA binds She3; Spider biofilm induced CAALFM_CR06450WA Ortholog(s) have polynucleotide 5'-hydroxyl-kinase activity and role in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), termination of RNA polymerase I transcription CAALFM_CR06460WA Glutathione S-transferase; expression regulated upon white-opaque switch; induced by human neutrophils; peroxide-induced; induced by alpha pheromone in SpiderM medium; Spider biofilm induced CAALFM_CR06470WA Ortholog(s) have ubiquitin protein ligase activity CAALFM_CR06480CA Putative RNA polymerase I subunit; rat catheter biofilm induced; Spider biofilm induced CAALFM_CR06490CA Heat shock protein; soluble in hyphae; regulated by Nrg1 and by iron; induced in high iron; heavy metal (cadmium) stress-induced; sumoylation target; protein present in exponential and stationary phase cells; Hap43-repressed CAALFM_CR06500CA Protein of unknown function; Hap43-induced; regulated by Nrg1, Tup1; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms CAALFM_CR06510WA Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_CR06520CA Ortholog(s) have GTPase activity, role in intracellular protein transport, retrograde transport, endosome to Golgi and Golgi apparatus, cis-Golgi network, cytosol localization CAALFM_CR06530WA Ortholog(s) have role in hydrogen peroxide-mediated programmed cell death and cytoplasm, nucleus localization CAALFM_CR06540WA Non-essential kinesin from the bipolar (Kinesis-5) family; involved in formation of the mitotic spindle CAALFM_CR06550CA Protein of unknown function; induced by nitric oxide; predicted ORF from Assembly 19; removed from Assembly 20; restored based on transcription data CAALFM_CR06560CA Putative protein involved in apoptosis; Spider biofilm induced CAALFM_CR06570CA Protein of unknown function; Spider biofilm induced CAALFM_CR06580WA Protein of unknown function; Spider biofilm induced; rat catheter biofilm repressed CAALFM_CR06590CA Protein of RGS superfamily; mutants are viable; rat catheter and Spider biofilm induced CAALFM_CR06610WA Receptor for alpha factor mating pheromone, MFalpha; required for a-type cells to respond to alpha factor, for opaque a-form mating and white a-form response; possible Kex2p substrate; a-specific, alpha-factor induced, A1p-Alpha2p repressed CAALFM_CR06620WA Ortholog(s) have mitochondrial outer membrane localization CAALFM_CR06640CA Integral ER membrane protein; predicted role in maintenance of ER zinc homeostasis; Spider biofilm induced CAALFM_CR06650CA Protein of unknown function; flow model, rat catheter, Spider biofilm induced CAALFM_CR06660WA Protein with similarity to permeases; Sfu1-repressed; flucytosine induced; induced by Mnl1 under weak acid stress; flow model biofilm repressed CAALFM_CR06670WA Protein similar to ferric reductase Fre10p; flucytosine repressed; possibly adherence-induced; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter biofilm repressed CAALFM_CR06680CA Ortholog(s) have DNA helicase activity, mRNA binding activity, role in regulation of translational termination and cytoplasmic stress granule, polysome localization CAALFM_CR06690CA Ortholog(s) have 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity, role in cyclic nucleotide metabolic process and clathrin-coated vesicle localization CAALFM_CR06700CA Putative 6-phosphogluconolactonase; present in exponential and stationary growth phase yeast cultures; macrophage-downregulated protein; Spider biofilm repressed CAALFM_CR06710CA Histone acetyltransferase; required for hyphen elongation and cell wall organization; mutation confers hypersensitivity to 5-fluorouracil (5-FU) CAALFM_CR06720WA Putative nonsense-mediated mRNA decay protein; repressed in core stress response; repressed by prostaglandins CAALFM_CR06730WA Ortholog(s) have Atg12 activating enzyme activity, Atg8 activating enzyme activity CAALFM_CR06740WA Ortholog(s) have structural constituent of cytoskeleton activity CAALFM_CR06750CA Alpha5 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures CAALFM_CR06760CA Putative succinate-CoA ligase beta subunit; regulated by Mig1, Tup1; induced in high iron; protein present in exponential and stationary growth phase yeast cells; Spider biofilm repressed CAALFM_CR06770CA Putative L-azetidine-2-carboxylic acid acetyltransferase; mutants are viable CAALFM_CR06780WA Ortholog(s) have histone deacetylase activity CAALFM_CR06790CA Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); Gcn4p-regulated; flucytosine induced; ketoconazole-repressed; oxidative stress-induced via Cap1p CAALFM_CR06800CA Putative histone H4; regulated by Efg1; flucytosine, fluconazole-induced; amphotericin B, caspofungin repressed; colony morphology-related gene regulation by Ssn6; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_CR06810WA Putative histone H3; farnesol regulated; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_CR06820WA Ortholog(s) have mitochondrion localization CAALFM_CR06830CA Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Siw14p; mutant shows virulence defect; Hap43p-repressed gene CAALFM_CR06840WA Ortholog(s) have U3 snoRNA binding, rRNA binding activity, role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, small-subunit processome localization CAALFM_CR06850CA Ortholog of S. cerevisiae : KSH1, C. dubliniensis CD36 : Cd36_32390, C. parapsilosis CDC317 : CPAR2_203260, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116778 and Debaryomyces hansenii CBS767 : DEHA2A10604g CAALFM_CR06860CA Aromatic decarboxylase; Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; alkaline repressed; protein abundance affected by URA3 expression in CAI-4 strain; Spider biofilm induced CAALFM_CR06870CA Protein similar to ferric reductase Fre10p CAALFM_CR06900CA Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; repressed by nitric oxide; possibly essential gene, disruptants not obtained by UAU1 method CAALFM_CR06910WA Predicted GTP/GDP exchange factor for Rsr1; rat catheter biofilm induced CAALFM_CR06920WA Protein of unknown function; Hap43-induced gene CAALFM_CR06930WA Ortholog of C. dubliniensis CD36 : Cd36_32460, C. parapsilosis CDC317 : CPAR2_205480, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115156 and Debaryomyces hansenii CBS767 : DEHA2E22154g CAALFM_CR06940WA Protein similar to S. cerevisiae Dsl1p, which is a member of the t-SNARE complex of the endoplasmic reticulum CAALFM_CR06950CA Putative cytosolic copper metallochaperone; flucytosine induced; Ssr1-repressed; rat catheter biofilm induced CAALFM_CR06960WA Ortholog(s) have ATP binding, DNA replication origin binding activity CAALFM_CR06970CA Predicted component of U5 snRNP; Spider biofilm induced CAALFM_CR06980WA Putative protein of unknown function; Hap43-induced; repressed by Rim101; Spider biofilm induced CAALFM_CR06990WA Has domain(s) with predicted DNA binding activity and role in DNA integration CAALFM_CR07000CA DNA polymerase epsilon; transcript induced by interaction with macrophage; transcript is regulated by Tup1; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_CR07010WA Predicted mitochondrial C1-tetrahydrofolate synthase precursor; putative protein of glycine catabolism; repressed by Efg1; fluconazole-induced; stationary phase enriched protein; rat catheter and Spider biofilm repressed CAALFM_CR07020WA Ortholog(s) have thiosulfate sulfurtransferase activity and mitochondrion localization CAALFM_CR07030CA Putative 90S preribosome component; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR07040WA Ortholog(s) have promoter-specific chromatin binding, sequence-specific DNA binding activity CAALFM_CR07050CA Putative bifunctional carbamoylphosphate synthetase-aspartate transcarbamylase; flucytosine induced; macrophage/pseudohyphal-induced; 5'-UTR intron; flow model biofilm repressed CAALFM_CR07060CA C2H2 transcription factor; crz1 not crz2 null mutation suppresses fluconazole resistance of homozygous cka2 null; Rim101-repressed at pH 8; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_CR07070CA Cell wall adhesin; epithelial adhesion, endothelial invasion; alleles vary in adhesiveness; immunoprotective in mice; binds SspB adhesin of S. gordonii in mixed biofilm; induced in/required for Spider biofilm; flow model biofilm repressed CAALFM_CR07080WA Ortholog of S. cerevisae/S. pombe Tif6; constituent of 66S pre-ribosomal particles; Spider biofilm induced CAALFM_CR07090WA Putative phosphatidylinositol-4-kinase CAALFM_CR07100WA Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc2p CAALFM_CR07110CA Ortholog of C. dubliniensis CD36 : Cd36_32690, C. parapsilosis CDC317 : CPAR2_204290, Candida tenuis NRRL Y-1498 : CANTEDRAFT_121459 and Debaryomyces hansenii CBS767 : DEHA2E03938g CAALFM_CR07120CA Ortholog of C. dubliniensis CD36 : Cd36_32700, C. parapsilosis CDC317 : CPAR2_204280, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113831 and Debaryomyces hansenii CBS767 : DEHA2E03916g CAALFM_CR07130CA Alkane-inducible cytochrome P450; catalyzes hydroxylation of lauric acid to hydroxylauric acid; overproduction causes fluconazole resistance in WT and causes multidrug resistance in a cdr1 cdr2 double mutant; rat catheter biofilm repressed CAALFM_CR07140CA Protein of unknown function; transcript regulated by Mig1 and Tup1; rat catheter biofilm induced CAALFM_CR07150WA Putative glucokinase; transcript regulated upon yeast-hyphal switch; Efg1 regulated; fluconazole-induced; induced in core stress response; colony morphology-related gene regulation by Ssn6; GlcNAc-induced protein CAALFM_CR07160CA Ortholog(s) have endoplasmic reticulum localization CAALFM_CR07170WA Possible dehydrogenase; flow model biofilm induced; rat catheter biofilm induced; Spider biofilm induced CAALFM_CR07180WA Protein similar to S. cerevisiae Emp46, an integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; induced by alpha pheromone in SpiderM medium CAALFM_CR07190WA Ortholog(s) have GTPase activator activity and role in establishment or maintenance of actin cytoskeleton polarity, small GTPase mediated signal transduction CAALFM_CR07200WA Ortholog of C. dubliniensis CD36 : Cd36_32830, C. parapsilosis CDC317 : CPAR2_205930, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115846 and Debaryomyces hansenii CBS767 : DEHA2E06072g CAALFM_CR07210WA Putative ARP2/3 complex subunit; mutation confers hypersensitivity to cytochalasin D CAALFM_CR07220CA Homolog of nuclear distribution factor NudE, NUDEL; regulates dynein targeting to microtubule plus ends; flow model biofilm repressed CAALFM_CR07230WA Putative histone chaperone; role in chromatin remodeling; rat catheter and Spider biofilm repressed CAALFM_CR07240CA Putative cyclin-like protein; transcription is regulated upon yeast-hyphal switch CAALFM_CR07250CA Predicted long-chain-alcohol oxidase; Spider biofilm induced CAALFM_CR07260CA Ortholog(s) have double-stranded DNA binding activity, role in reciprocal meiotic recombination and condensed nuclear chromosome localization CAALFM_CR07270CA Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium with 2% glucose CAALFM_CR07280WA Protein with similarity to ferric reductases; downregulated in response to amphotericin B, estradiol, or ciclopirox olamine, and upregulated by interaction with macrophage; un-merged from orf19.6139 in a revision of Assembly 21 CAALFM_CR07290WA Copper-regulated cupric reductase; repressed by ciclopirox olamine or 17-beta-estradiol; induced by alkaline conditions or interaction with macrophage; Spider biofilm induced CAALFM_CR07300WA Protein similar to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR07310WA Has domain(s) with predicted ATP binding, ATP-dependent helicase activity, nucleic acid binding activity CAALFM_CR07320CA Ortholog of S. cerevisiae Mrpl4, a mitochondrial ribosomal protein of the large subunit; repressed by nitric oxide CAALFM_CR07330WA Component of heteroheptameric complexes (Lsm1p, Lsm8p) involved in RNA processing and decay; flucytosine induced CAALFM_CR07340CA Ortholog of C. dubliniensis CD36 : Cd36_32970, C. parapsilosis CDC317 : CPAR2_701710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_106599 and Debaryomyces hansenii CBS767 : DEHA2E04488g CAALFM_CR07350WA Ortholog(s) have role in ER-dependent peroxisome organization, retrograde vesicle-mediated transport, Golgi to ER and Dsl1p complex, endoplasmic reticulum membrane, nuclear envelope, peroxisome localization CAALFM_CR07360WA Putative DNA helicase; decreased transcription is observed upon fluphenazine treatment CAALFM_CR07370WA Ortholog of C. dubliniensis CD36 : Cd36_33000, C. parapsilosis CDC317 : CPAR2_701740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93887 and Debaryomyces hansenii CBS767 : DEHA2E04554g CAALFM_CR07380CA 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis CAALFM_CR07390CA Mitochondrial 60S ribosomal protein subunit; Hap43p-repressed gene CAALFM_CR07400CA Putative dihydrolipoamide dehydrogenase; soluble in hyphae; antigenic in human oral infection and murine systemic infection; macrophage-induced protein; protein present in exponential and stationary phase yeast cultures; Hap43p-repressed CAALFM_CR07420WA Putative dihydrolipoamide S-succinyltransferase; induced in high iron; Hap43-repressed; Spider biofilm repressed CAALFM_CR07440WA Transcription factor; similar to S. cerevisiae Ace2 and Swi5; regulates morphogenesis, cell separation, adherence, virulence in a mice; mutant is hyperfilamentous; rat catheter and Spider biofilm induced CAALFM_CR07450CA Transcription factor; induces transcripts of stress response genes via SLE (STRE-like) elements; required for adaptation to weak acid stress; activates a subset of the genes that are repressed by Nrg1 CAALFM_CR07460CA Protein of unknown function; Spider biofilm repressed CAALFM_CR07470WA Putative guanine nucleotide dissociation stimulator; transcription is positively regulated by Tbf1p CAALFM_CR07480WA S. pombe ortholog SPAC5D6.04 is a predicted auxin family transmembrane transporter; ketoconazole and hypoxia induced CAALFM_CR07490CA Putative glucokinase; decreased expression in hyphae compared to yeast-form cells CAALFM_CR07500WA Ortholog of C. dubliniensis CD36 : Cd36_33120 and Candida albicans WO-1 : CAWG_02046 CAALFM_CR07510WA Ortholog(s) have role in mRNA splicing, via spliceosome and U1 snRNP, U2 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol localization CAALFM_CR07520CA Protein required for resistance to toxic ergosterol analog CAALFM_CR07530CA Zn(II)2Cys6 transcription factor; rat catheter and Spider biofilm induced CAALFM_CR07540CA Protein of unknown function; downregulated by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 CAALFM_CR07560WA Putative Rho GTPase activating protein; fungal-specific (no human or murine homolog) CAALFM_CR07570WA Adaptor protein required for specific mRNA transport; protein similar but not orthologous to S. cerevisiae She3; transposon mutation affects filamentous growth CAALFM_CR07580CA Protein similar to S. cerevisiae Tsc11p which is involved in sphingolipid biosynthesis; transposon mutation affects filamentous growth CAALFM_CR07590WA COPII-coated vesicle component CAALFM_CR07600WA Ortholog(s) have DNA binding, DNA-dependent ATPase activity, chromatin binding activity CAALFM_CR07620WA Putative aspartate aminotransferase; stationary phase enriched protein; Gcn4-regulated; Spider biofilm induced CAALFM_CR07630CA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_CR07640CA Ortholog(s) have ATPase activator activity, role in positive regulation of ATPase activity, vacuolar transport and endosome localization CAALFM_CR07650WA Putative catalytic subunit of type 1 serine/threonine protein phosphatase; regulated by Shp1; induced in high iron; alternatively spliced intron in 5' UTR CAALFM_CR07660CA Ortholog(s) have GTP binding, signal recognition particle binding activity, role in protein targeting to ER and integral component of endoplasmic reticulum membrane, signal recognition particle receptor complex localization CAALFM_CR07670WA Ortholog(s) have mitochondrion localization CAALFM_CR07680CA Has domain(s) with predicted nucleic acid binding, nucleotide binding activity CAALFM_CR07690WA Ortholog of C. dubliniensis CD36 : Cd36_33330, C. parapsilosis CDC317 : CPAR2_701980, Debaryomyces hansenii CBS767 : DEHA2C15840g and Pichia stipitis Pignal : PICST_31066 CAALFM_CR07700WA Has aminoglycoside phosphotransferase and protein kinase domains; rat catheter and flow model biofilm induced CAALFM_CR07710WA Putative chorismate synthase; fungal-specific (no human or murine homolog); protein level decreased in stationary phase yeast cultures; GlcNAc-induced protein CAALFM_CR07720CA Putative DNA replication initiation factor; transcriptionally regulated by interaction with macrophage CAALFM_CR07730WA Putative MFS glucose transporter; 20 member C. albicans glucose transporter family; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose; rat catheter and flow model biofilm induced CAALFM_CR07740WA Ortholog of C. dubliniensis CD36 : Cd36_00150 and Lodderomyces elongisporus NRLL YB-4239 : LELG_01269 CAALFM_CR07750CA Ortholog(s) have role in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) CAALFM_CR07760WA Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization CAALFM_CR07770CA Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), functional homolog of S. cerevisiae Ptc6p; mutant shows virulence defect CAALFM_CR07780WA Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process CAALFM_CR07790CA Nitric oxide dioxygenase; acts in nitric oxide scavenging/detoxification; role in virulence in mouse; transcript activated by NO, macrophage interaction; Hap43, hypha repressed; mRNA binds She3 CAALFM_CR07800WA Major secreted aspartyl proteinase; utilization of protein as nitrogen source; role in virulence complicated by URA3 effects; immunoprotective; regulated by growth, albumin, drugs, white cell-type; flow model biofilm induced CAALFM_CR07810WA Flavohemoglobin-related protein; not required for normal NO resistance; predicted globin/FAD-binding/NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; filament induced; rat catheter and Spider biofilm induced CAALFM_CR07820WA Protein with monooxygenase domains; flow model biofilm induced CAALFM_CR07830CA Protein of unknown function; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced CAALFM_CR07840CA Protein of unknown function; flow model biofilm induced; Spider biofilm induced; induced by Mnl1 under weak acid stress; transcript detected in high-resolution tiling arrays CAALFM_CR07850WA Ortholog of C. dubliniensis CD36 : Cd36_33530, C. parapsilosis CDC317 : CPAR2_201980, Candida tenuis NRRL Y-1498 : CANTEDRAFT_134293 and Debaryomyces hansenii CBS767 : DEHA2A10164g CAALFM_CR07860CA Protein similar to S. cerevisiae Asf1p, a chromatin assembly complex component; likely to be essential for growth, based on an insertional mutagenesis strategy CAALFM_CR07870WA Ortholog of S. cerevisiae : AIM32, C. glabrata CBS138 : CAGL0L01529g, C. dubliniensis CD36 : Cd36_33550, C. parapsilosis CDC317 : CPAR2_702070 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_114174 CAALFM_CR07890WA bHLH transcription factor; required for white-phase cell type, RPMI and Spider biofilm formation, hyphal growth, cell-wall gene regulation; roles in adhesion, virulence; Cph1 and Efg1 have role in host cytokine response; binds E-box CAALFM_CR07910CA Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; Spider biofilm induced CAALFM_CR07920WA Protein of unknown function; Hap43-induced; Spider biofilm induced CAALFM_CR07940WA Ortholog(s) have cytosol localization CAALFM_CR07950WA Putative SSU processome component; Hap43-induced; repressed by prostaglandins; Spider biofilm induced CAALFM_CR07960CA Potassium transporter; mediates K+ and Cl- influx; role in sensitivity to cationic antimicrobial peptides, not by direct uptake, possibly related to membrane permeability; contains 5' UTR intron; Spider biofilm induced CAALFM_CR08000CA Protein with an aspartate aminotransferase domain; Gcn4-regulated CAALFM_CR08010WA Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules CAALFM_CR08020CA Small nucleolar ribonucleoprotein; flucytosine induced CAALFM_CR08030CA Protein similar to S. cerevisiae Swa2p; induced upon adherence to polystyrene; transposon mutation affects filamentous growth; Hap43p-repressed gene CAALFM_CR08040WA Ortholog of S. cerevisiae YNL092W and S. pombe SPBC1778.07; a putative N2227-like methyltransferase; Hap43-repressed gene CAALFM_CR08050CA Putative thiamine biosynthesis enzyme; decreased expression in an ssr1 null mutant; protein present in exponential and stationary growth phase yeast cultures CAALFM_CR08060CA Late endosomal Rab small monomeric GTPase involved in transport of endocytosed proteins to the vacuole; involved in filamentous growth and virulence; Spider biofilm induced CAALFM_CR08070WA Phosphotyrosine-specific protein phosphatase; rat catheter biofilm induced CAALFM_CR08080WA Has domain(s) with predicted RNA binding activity CAALFM_CR08090WA HSP70 family heat shock protein; mRNA in yeast and germ tubes; at yeast cell surface, not hyphae; antigenic in human/mouse infection; macrophage, GCN-induced; possibly essential; sumoylation target; Hap43-induced; Spider biofilm repressed CAALFM_CR08100CA Putative serine kinase with a predicted role in the processing of the 20S pre-rRNA into mature 18S rRNA; null mutants are hypersensitive to caspofungin CAALFM_CR08110WA Ortholog of C. dubliniensis CD36 : Cd36_33750, C. parapsilosis CDC317 : CPAR2_205650, Candida tenuis NRRL Y-1498 : cten_CGOB_00253 and Debaryomyces hansenii CBS767 : DEHA2A11088g CAALFM_CR08120CA Ortholog(s) have chromatin binding, m7G(5')pppN diphosphatase activity, mRNA binding activity CAALFM_CR08130WA Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and integral component of mitochondrial membrane, mitochondrial inner membrane localization CAALFM_CR08150WA Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed CAALFM_CR08160WA Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), involved in drug response and cadmium tolerance CAALFM_CR08170CA Ortholog(s) have protein C-terminal leucine carboxyl O-methyltransferase activity, role in C-terminal protein methylation, cellular protein complex assembly, regulation of autophagy and mitochondrion localization CAALFM_CR08180CA Putative tRNA methyltransferase; repressed during the mating process CAALFM_CR08190WA Ortholog of C. dubliniensis CD36 : Cd36_33820, C. parapsilosis CDC317 : CPAR2_206210, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92567 and Debaryomyces hansenii CBS767 : DEHA2E06138g CAALFM_CR08200CA Putative MRP/CFTR-subfamily ABC transporter; member of multidrug resistance-associated protein (MRP) subfamily of ABC family; similar to S. cerevisiae Bpt1p CAALFM_CR08210CA Aconitase; induced in high iron; 2 upstream CCAAT motifs; amino acid starvation (3-AT), amphotericin B, phagocytosis, farnesol induced; Hap43, fluconazole-repressed; Gcn4-regulated; antigenic in infection; flow and Spider biofilm repressed CAALFM_CR08250CA Heat-shock protein; roles in biofilm and virulence; complements chaperone, prion activity in S. cerevisiae; guanidine-insensitive; heat shock/stress induced; repressed in farnesol-treated biofilm; sumoylation target; Spider biofilm induced CAALFM_CR08260CA Protein of unknown function; Spider biofilm induced CAALFM_CR08270WA Protein of unknown function; transcript upregulated in azole-resistant strain overexpressing MDR1; Spider biofilm induced CAALFM_CR08280WA Ortholog of C. dubliniensis CD36 : Cd36_33870, C. parapsilosis CDC317 : CPAR2_204450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113827 and Debaryomyces hansenii CBS767 : DEHA2E04158g CAALFM_CR08290WA Putative Arf3p GTPase activating protein; Hap43p-repressed gene; possibly an essential gene, disruptants not obtained by UAU1 method CAALFM_CR08300CA Putative patatin-like phospholipase; similar to S. cerevisiae Nte1p, which is predicted to be a membrane protein; antigenic during human oral infection; Hap43p-repressed gene CAALFM_CR08310CA S. pombe ortholog SPBC460.04c is a predicted sulfonate/alpha-ketoglutare dioxygenase; induced by nitric oxide; Spider biofilm induced CAALFM_CR08320WA Protein required for modification of wobble nucleosides in tRNA; induced upon adherence to polystyrene; regulated by Sef1, Sfu1, and Hap43 CAALFM_CR08330WA Ortholog(s) have role in inositol metabolic process and cytosol, nuclear envelope localization CAALFM_CR08340WA Cystathionine gamma-lyase; induced by alkaline, amphotericin B, cadmium stress, oxidative stress via Cap1; possibly adherence-induced; Hog1 regulated; reduced levels in stationary phase yeast cells; Spider and flow model biofilm induced CAALFM_CR08350WA Ortholog(s) have adenyl-nucleotide exchange factor activity, role in SRP-dependent cotranslational protein targeting to membrane, translocation and endoplasmic reticulum localization CAALFM_CR08360CA Acidic ribosomal protein; likely role in translation elongation regulation; interacts with Rpp1B; 1 of 4 similar ribosomal proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); CUG start codon; upstream uORFs; Tbf1-induced; Spider biofilm repressed CAALFM_CR08370WA Putative glutathione synthase; induced in high iron; heavy metal (cadmium) stress-induced CAALFM_CR08380CA Protein of unknown function; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 CAALFM_CR08400CA Ortholog(s) have cytosol, mitochondrial ribosome, nucleus localization CAALFM_CR08410WA Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, cytosolic large ribosomal subunit, preribosome, large subunit precursor localization CAALFM_CR08420WA Putative DnaJ-like heat shock/chaperone; Hap43-repressed; Spider and F-12/CO2 biofilm induced CAALFM_CR08430WA Protein similar to S. cerevisiae Vac14p; a protein involved in regulated synthesis of PtdIns(3,5)P(2); transposon mutation affects filamentous growth CAALFM_CR08440WA Protein of unknown function; rat catheter biofilm induced CAALFM_CR08450CA Ortholog of C. dubliniensis CD36 : Cd36_34040, C. parapsilosis CDC317 : CPAR2_205850, Candida tenuis NRRL Y-1498 : CANTEDRAFT_132607 and Debaryomyces hansenii CBS767 : DEHA2A11638g CAALFM_CR08460WA Putative tropomyosin isoform 2; regulated by Gcn4; repressed by amino acid starvation; macrophage-induced; protein levels decrease in stationary cells; Hap43-induced; rat catheter and Spider biofilm repressed CAALFM_CR08470WA Protein involved in N-glycosylation; Spider biofilm induced; rat catheter biofilm repressed CAALFM_CR08480CA Ortholog(s) have structural constituent of ribosome activity and cytosolic small ribosomal subunit, nucleus localization CAALFM_CR08490WA Component of 20S pre-rRNA processing unit; repressed by prostaglandins CAALFM_CR08500WA Ortholog(s) have unfolded protein binding activity, role in protein import into nucleus, ribosomal large subunit biogenesis and cytoplasm, nucleus localization CAALFM_CR08510WA GPI-anchored cell wall protein involved in cell wall synthesis; required for normal cell surface properties; induced in oralpharyngeal candidasis; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms CAALFM_CR08520CA Ortholog of C. parapsilosis CDC317 : CPAR2_205710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117073, Lodderomyces elongisporus NRLL YB-4239 : LELG_02945 and Debaryomyces hansenii CBS767 : DEHA2A11462g CAALFM_CR08540CA Ortholog(s) have serine-type endopeptidase activity, role in protein processing, response to amino acid and extrinsic component of plasma membrane localization CAALFM_CR08550WA Ortholog(s) have fructose-2,6-bisphosphate 2-phosphatase activity, role in glucose metabolic process and cytoplasm localization CAALFM_CR08560CA Ortholog(s) have SUMO transferase activity, role in hyphal growth, mitotic spindle elongation and condensed nuclear chromosome, cytosol, nuclear heterochromatin localization CAALFM_CR08570WA Ortholog(s) have mRNA binding activity, role in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay and Ski complex, cytosol localization CAALFM_CR08580CA Protein of unknown function; Spider biofilm induced CAALFM_CR08590WA Ortholog(s) have ATPase activity, role in response to drug, ribosomal large subunit biogenesis and cytosol, preribosome, large subunit precursor localization CAALFM_CR08600CA Ortholog(s) have peroxisome membrane targeting sequence binding activity CAALFM_CR08610WA Highly conserved subunit of mitochondrial pyruvate carrier; Hap43-repressed; Spider biofilm repressed CAALFM_CR08620CA Ortholog of C. dubliniensis CD36 : Cd36_34210, C. parapsilosis CDC317 : CPAR2_205590, Candida tenuis NRRL Y-1498 : cten_CGOB_00133 and Debaryomyces hansenii CBS767 : DEHA2E02178g CAALFM_CR08630WA Similar to anaphase-promoting complex component; possibly transcriptionally regulated by Tac1p CAALFM_CR08640CA Ortholog(s) have serine C-palmitoyltransferase activity, role in sphingolipid biosynthetic process and SPOTS complex localization CAALFM_CR08650CA Ortholog(s) have ubiquitin-protein transferase activity, role in cellular response to amino acid stimulus, transcription factor catabolic process and Asi complex localization CAALFM_CR08660WA Protein similar to S. cerevisiae Prp8, a component of the U4/U6-U5 snRNP complex; repressed by alpha pheromone in SpiderM medium CAALFM_CR08670CA Protein with an enoyl-CoA hydratase related domain; Spider biofilm induced CAALFM_CR08680CA Ortholog(s) have role in meiotic nuclear division, negative regulation of TOR signaling, negative regulation of small GTPase mediated signal transduction and positive regulation of autophagy, more CAALFM_CR08690CA Protein similar to S. cerevisiae Eci1p, which is involved in fatty acid oxidation; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching CAALFM_CR08700CA ADP-ribosylation factor; probable GTPase involved in intracellular transport; one of several C. albicans ADP-ribosylation factors; N-myristoylprotein; substrate of Nmt1; Spider biofilm induced CAALFM_CR08710WA Protein of unknown function; Spider biofilm repressed CAALFM_CR08720WA Ortholog of C. dubliniensis CD36 : Cd36_34310 CAALFM_CR08740WA Protein of unknown function CAALFM_CR08820CA Ortholog of S. cerevisiae Tar1p; Transcript Antisense to Ribosomal RNA; encoded within the 25S rRNA gene on the opposite strand; induced by Tbf1 CAALFM_CR08830WA Protein of unknown function; Spider biofilm induced CAALFM_CR08840CA Putative carbon-nitrogen hydrolase; rat catheter biofilm repressed CAALFM_CR08860WA Putative pyruvate dehydrogenase kinase; mutation confers hypersensitivity to amphotericin B CAALFM_CR08870WA Protein required for peroxisomal protein import mediated by PTS1 and PTS2 targeting sequences; transcript induced in an RHE model of oral candidiasis; Hap43-repressed gene CAALFM_CR08880CA Protein of unknown function; rat catheter and Spider biofilm induced CAALFM_CR08890CA Adenylyl cyclase and stress responsive protein; induced in cyr1 or ras1 mutant; stationary phase enriched protein; Spider biofilm induced CAALFM_CR08900CA Ortholog(s) have role in mRNA polyadenylation, pre-mRNA cleavage required for polyadenylation, snoRNA 3'-end processing, termination of RNA polymerase II transcription and exosome-dependent, more CAALFM_CR08910CA Subunit of the proteasome regulatory particle; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures CAALFM_CR08920WA Protein with predicted oxidoreductase and dehydrogenase domains; Hap43-repressed; Spider biofilm induced CAALFM_CR08930CA Ortholog(s) have RNA cap binding, chromatin binding, mRNA binding activity and role in deadenylation-dependent decapping of nuclear-transcribed mRNA CAALFM_CR08940WA Ortholog(s) have tRNA (adenine-N1-)-methyltransferase activity, role in tRNA methylation and cytosol, nucleus, tRNA (m1A) methyltransferase complex localization CAALFM_CR08950WA Component of the Arp2/3 complex; required for virulence, hyphal growth, cell wall/cytoskeleton organization, not for endocytosis; mutation confers hypersensitivity to cytochalasin D; regulated by Gcn2 and Gcn4; Spider biofilm repressed CAALFM_CR08960CA Monopolar spindle protein, putative spindle assembly checkpoint kinase; essential for growth; involved in oxidative stress response; periodic mRNA expression, peak at cell-cycle S/G2 phase CAALFM_CR08980CA Ortholog(s) have protein phosphatase 1 binding activity, role in actin filament organization, cortical actin cytoskeleton organization, endocytosis, protein secretion and actin cortical patch, nucleus localization CAALFM_CR08990CA Putative cation conductance protein; similar to stomatin mechanoreception protein; plasma-membrane localized; induced by Rgt1; rat catheter and Spider biofilm induced CAALFM_CR09010CA Putative cystathionine gamma-synthase; decreased levels in stationary phase cultures; Hog1p-induced; Gcn4p-regulated CAALFM_CR09020CA Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcript regulated during dimorphic transition; Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289; flow model biofilm repressed CAALFM_CR09040WA Protein of unknown function; Spider biofilm induced CAALFM_CR09050CA Has domain(s) with predicted DNA binding, nucleic acid binding activity CAALFM_CR09060WA Ortholog of C. dubliniensis CD36 : Cd36_34495, Candida tropicalis MYA-3404 : CTRG_05947 and Candida albicans WO-1 : CAWG_02181 CAALFM_CR09070CA Protein of unknown function; Hap43-induced; transcript induced early in infection of reconstituted human epithelium, while expression of the C. dubliniensis ortholog is not upregulated; mutants are viable; rat catheter biofilm repressed CAALFM_CR09090CA Ortholog of C. dubliniensis CD36 : Cd36_34510, Candida tropicalis MYA-3404 : CTRG_05938 and Candida albicans WO-1 : CAWG_02183 CAALFM_CR09100CA Aldo-keto reductase; increased transcript associated with MDR1 overexpression, benomyl or long-term fluconazole treatment; overexpression does not affect drug or oxidative stress sensitivity; stationary phase enriched; flow biofim repressed CAALFM_CR09110CA Putative oxidoreductase; similar to S. cerevisiae Pga3p; possible Kex2p substrate CAALFM_CR09120CA Alpha-tubulin; gene has intron; complements cold-sensitivity of S. cerevisiae tub1 mutant; C. albicans has single alpha-tubulin gene, whereas S. cerevisiae has two (TUB1, TUB3); farnesol-upregulated in biofilm; sumoylation target CAALFM_CR09140CA Protein with a role in directing meiotic recombination events to homologous chromatids; induced by ciclopirox olamine; positively regulated by Sfu1; Hog1, fluconazole-repressed; Hap43-induced; Spider biofilm induced CAALFM_CR09150WA Protein of unknown function; Spider biofilm induced CAALFM_CR09160CA 3-hydroxy-3-methylglutaryl coenzyme A synthase; ergosterol biosynthesis; sumoylation target; Tn mutation affects filamentation; amphotericin B, caspofungin repressed; exponential, stationary growth phase expressed; Spider biofilm repressed CAALFM_CR09170CA Protein similar to S. cerevisiae Ssu1 sulfite transport protein; Tn mutation affects filamentous growth; regulated by Gcn2 and Gcn4; induced by nitric oxide; Hap43-repressed; Spider and flow model biofilm induced CAALFM_CR09180WA Putative cysteine dioxygenases; role in conversion of cysteine to sulfite; transcript regulated upon white-opaque switch; rat catheter, Spider and flow model biofilm induced CAALFM_CR09190CA Putative phytanoyl-CoA dioxygenase family protein; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); induced by nitric oxide CAALFM_CR09200CA Zinc-finger transcription factor; similar to S. cerevisiae Uga3 which regulates gamma-aminobutyrate metabolism gene expression; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced CAALFM_CR09210WA Zinc-finger transcription factor; regulates alpha-glucosidase exression; complements S. cerevisiae suc2 for sucrose utilization and mal13 maltase defect; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced CAALFM_CR09220CA Probable lipase, part of a gene family whose members are differentially expressed during infection; lacks a signal sequence for secretion, unlike other family members; may have a role in nutrition or in creating an acidic microenvironment CAALFM_CR09230CA Ortholog(s) have role in re-entry into mitotic cell cycle after pheromone arrest and endoplasmic reticulum localization CAALFM_CR09240CA Protein of unknown function; S. cerevisae ortholog Ypl225w interacts with ribosomes; rat catheter biofilm induced CAALFM_CR09270CA Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1, Tup1; Spider biofilm induced CAALFM_CR09290WA Thiamin pyrimidine synthase; synthesis of the thiamine precursor hydroxymethylpyrimidine phosphate; single-turnover enzyme that provides histidine for HMP-P formation; induced by nitric oxide independent of Yhb1; Spider biofilm induced CAALFM_CR09300CA Putative copper transporter; Hap43p-repressed gene CAALFM_CR09310WA Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine dimethylation, peptidyl-lysine monomethylation and cytoplasm, nucleus localization CAALFM_CR09320CA Protein with a role in phosphate transport; biofilm-regulated expression; amphotericin B repressed CAALFM_CR09330CA Protein with a Staphylococcal nuclease domain; transcript regulated by Mig1 and Tup1; flow model and Spider biofilm repressed CAALFM_CR09340WA Ortholog(s) have ubiquitin-protein transferase activity CAALFM_CR09350CA Protein with a predicted heme oxygenase domain; Spider biofilm induced CAALFM_CR09360WA Putative transporter; more similar to S. cerevisiae Tpn1, which is a vitamin B6 transporter, than to purine-cytosine permeases; transcription is regulated by Nrg1; Spider biofilm induced CAALFM_CR09370WA Putative mRNA export protein; Walker A and B (ATP/GTP binding) motifs; required for wild-type morphology, growth; expressed in hyphal, pseudohyphal, and yeast form; Hap43-induced; Spider and flow model biofilm induced CAALFM_CR09380WA Putative alpha-2_sc subunit of proteasome; macrophage-induced protein; regulated by Gcn2p and Gcn4p; transcription is positively regulated by Tbf1p; stationary phase enriched protein CAALFM_CR09390CA Predicted membrane transporter; member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS); Spider biofilm induced CAALFM_CR09410WA Protein with a nischarin related domain and leucine rich repeats; Spider biofilm induced CAALFM_CR09420CA Putative glucanase; induced during cell wall regeneration CAALFM_CR09440CA Protein of unknown function; flow model biofilm induced; ketoconazole-repressed CAALFM_CR09460CA Protein of unknown function; Spider biofilm induced CAALFM_CR09470WA Putative endoprotease; induced by alpha factor; transcript is upregulated in an RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis CAALFM_CR09480WA Ortholog(s) have role in mRNA splicing, via spliceosome, snoRNA splicing and U4/U6 x U5 tri-snRNP complex localization CAALFM_CR09490WA Ortholog(s) have DNA binding, chromatin binding, histone deacetylase activity CAALFM_CR09500CA Ortholog(s) have ATP binding activity and cytosol, nucleus localization CAALFM_CR09510CA Putative mitochondrial protein; Hap43p-induced gene CAALFM_CR09520CA Ortholog(s) have microtubule plus-end binding, structural constituent of cytoskeleton activity CAALFM_CR09530CA Predicted DDE superfamily endonuclease domain; repression correlates with clinical development of fluconazole resistance; Spider biofilm induced CAALFM_CR09550CA NADH-ubiquinone oxidoreductase subunit with roles in mitochondrial respiratory chain complex I assembly CAALFM_CR09560CA Ortholog of C. parapsilosis CDC317 : CPAR2_201040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112677, Debaryomyces hansenii CBS767 : DEHA2E02420g and Pichia stipitis Pignal : PICST_37559 CAALFM_CR09570WA Ortholog(s) have fungal-type vacuole, mitochondrion localization CAALFM_CR09580CA Ortholog of S. cerevisiae Pba1 that is involved in 20S proteasome assembly; upregulated in a cyr1 null mutant; contains a 5' UTR intron CAALFM_CR09590WA Ortholog(s) have role in ubiquinone-6 biosynthetic process and mitochondrial inner membrane localization CAALFM_CR09600CA Possible heterohexameric Gim/prefoldin protein complex subunit; role in folding alpha-tubulin, beta-tubulin, and actin; transcript induced by yeast-to-hypha switch; regulated by Nrg1, Tup1; Spider and flow model biofilm induced CAALFM_CR09610CA Protein of unknown function; rat catheter and flow model biofilm induced CAALFM_CR09620CA Ortholog(s) have phosphatidic acid transporter activity and role in cardiolipin metabolic process, phospholipid transport, positive regulation of phosphatidylcholine biosynthetic process CAALFM_CR09640CA Ortholog(s) have role in cytoplasmic translation and cytoplasm, nucleus localization CAALFM_CR09650WA Protein required for hyphal growth and for wild-type cell morphology, polarized budding, endocytosis, vacuole morphology; similar to Wiskott-Aldrich syndrome protein; localizes to cortical actin patches and hyphal tips CAALFM_CR09660WA Ortholog(s) have cytoplasm localization CAALFM_CR09670CA Putative esterase; possibly transcriptionally regulated by Tac1; induced by Mnl1 under weak acid stress; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed CAALFM_CR09680CA Protein similar to S. cerevisiae Rsb1p, involved in fatty acid transport; transposon mutation affects filamentous growth; alkaline downregulated; caspofungin induced; possibly an essential gene; Hap43p-repressed CAALFM_CR09690CA GPI-anchored cell surface phospholipase B; possibly secreted; fungal-specific (no mammalian homolog); induced by Tbf1; fluconazole-induced; possible essential gene (UAU1 method); Spider and flow model biofilm induced CAALFM_CR09700WA Predicted membrane transporter, member of the aromatic acid:proton symporter (AAHS) family, major facilitator superfamily (MFS) CAALFM_CR09710WA Ortholog(s) have 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, role in DNA repair and peroxisome localization CAALFM_CR09720WA Ortholog(s) have unfolded protein binding activity and role in vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly CAALFM_CR09730CA Protein involved in ribosome biogenesis; ortholog of S. cerevisiae Ssf1; Hap43-induced; rat catheter and Spider biofilm induced CAALFM_CR09740WA Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; Spider biofilm induced CAALFM_CR09750CA Ortholog(s) have phosphatidylinositol-3-phosphate binding, ubiquitin-protein transferase activity, role in protein ubiquitination and cytosol, fungal-type vacuole membrane, late endosome, nucleus localization CAALFM_CR09760WA Ortholog(s) have RNA polymerase II repressing transcription factor binding, RNA polymerase II transcription coactivator activity, RNA polymerase II transcription corepressor activity CAALFM_CR09770CA Protein mannosyltransferase (PMT), expressed at extremely low levels; not required for wild-type hyphal growth, drug resistance, or virulence in mouse systemic infection; one of five PMT family members CAALFM_CR09780CA Putative LPF family protein; Plc1-regulated; induced by alpha pheromone in SpiderM medium CAALFM_CR09790WA D-Arabinono-1,4-lactone oxidase involved in biosynthesis of dehydro-D-arabinono-1,4-lactone, which has a protective role against oxidative damage; plasma membrane-localized;required for full virulence in a mouse model of systemic infection CAALFM_CR09800CA Putative U3-containing small subunit processome complex protein; Hap43-induced gene; repressed in core stress response; Spider biofilm induced CAALFM_CR09810WA Protein of unknown function; rat catheter biofilm repressed CAALFM_CR09830WA Transporter; similar to the Sit1 siderophore transporter; induced by nitric oxide independent of Yhb1; repressed during chlamydospore formation in C. albicans and C. dubliniensis; rat catheter biofilm repressed CAALFM_CR09840CA Ortholog of C. dubliniensis CD36 : Cd36_34965, C. parapsilosis CDC317 : CPAR2_200910, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95984 and Debaryomyces hansenii CBS767 : DEHA2E02926g CAALFM_CR09850CA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_CR09860WA Protein similar to S. cerevisiae Yta6p ATPase but ortholog of S. cervisiae Sap1; transposon mutation affects filamentous growth; induced by Mnl1 under weak acid stress CAALFM_CR09880WA RNA polymerase II regulator; role in filamentation, epithelial cell escape, dissemination in RHE model; induced by fluconazole, high cell density; Efg1/hyphal regulated; role in adhesion, hyphal growth on solid media; Spider biofilm induced CAALFM_CR09890CA Putative Type II geranylgeranyltransferase beta subunit; transcript regulated by Mig1 CAALFM_CR09900CA Probable subunit of DNA polymerase II (DNA polymerase epsilon), similar to S. cerevisiae Dpb2p; essential for viability; rat catheter biofilm induced CAALFM_CR09910WA Putative high-affinity glutamine permease; fungal-specific (no human or murine homolog) CAALFM_CR09920WA Predicted amino acid transport domain; transcript upregulated in clinical strains from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101; rat catheter, Spider and flow model biofilm induced CAALFM_CR09930WA Protein of unknown function; induced by alpha pheromone in SpiderM medium CAALFM_CR09940WA Ortholog(s) have lipid particle localization CAALFM_CR09950CA Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p CAALFM_CR09960CA Zn(II)2Cys6 transcription factor; required for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; mutants display decreased CFU in mouse kidneys; Spider biofilm induced CAALFM_CR09970WA Ortholog(s) have protein binding, bridging, ubiquitin binding, ubiquitin conjugating enzyme activity CAALFM_CR09980WA Putative SAGA transcriptional regulatory complex subunit; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B CAALFM_CR09990WA Ortholog(s) have ubiquitin ligase complex localization CAALFM_CR10000CA Ortholog of S. pombe atl1 alkyltransferase-like protein; mutants are viable; Spider biofilm induced CAALFM_CR10010CA Putative mRNA maturation factor; fungal-specific (no human or murine homolog) CAALFM_CR10020CA Ortholog(s) have oligosaccharide binding activity and role in ER-associated ubiquitin-dependent protein catabolic process, endoplasmic reticulum unfolded protein response, retrograde protein transport, ER to cytosol CAALFM_CR10030WA Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth CAALFM_CR10040WA Ortholog of C. dubliniensis CD36 : Cd36_35095, C. parapsilosis CDC317 : CPAR2_200710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112338 and Debaryomyces hansenii CBS767 : DEHA2G06094g CAALFM_CR10060WA Protein with a predicted role in assembly of U2 snRNP into the spliceosome; Spider biofilm induced CAALFM_CR10070CA Zn(II)2Cys6 transcription factor; mutants are viable; filament induced; required for yeast cell adherence to silicone substrate; Spider biofilm induced CAALFM_CR10100CA Inositol-1-phosphate synthase; antigenic in human; repressed by farnesol in biofilm or by caspofungin; upstream inositol/choline regulatory element; glycosylation predicted; rat catheter, flow model induced; Spider biofilm repressed CAALFM_CR10110WA Major chitinase; secreted; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylation; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p CAALFM_CR10120CA Ortholog(s) have mitochondrion localization CAALFM_CR10130WA Protein of unknown function; Hap43-repressed gene; transcript induced by elevated CO2 CAALFM_CR10140WA Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide CAALFM_CR10160WA Predicted acyl CoA synthase CAALFM_CR10170CA Putative asparaginase; predicted role in asparagine catabolism; Spider biofilm induced CAALFM_CR10180WA Protein of unknown function; Spider biofilm induced CAALFM_CR10190CA Has domain(s) with predicted dynactin complex localization CAALFM_CR10200WA Protein with a phosphoglycerate mutase family domain; Hap43-repressed gene CAALFM_CR10210WA Putative GPI-anchored protein CAALFM_CR10230WA Ortholog(s) have histone acetyltransferase activity, role in histone acetylation and Ada2/Gcn5/Ada3 transcription activator complex localization CAALFM_CR10240WA Putative U3 snoRNA-associated protein; Hap43p-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); physically interacts with TAP-tagged Nop1p CAALFM_CR10250CA Glutathione-dependent formaldehyde dehydrogenase; glycine catabolism; repressed by Efg1 in yeast, not hyphal growth conditions; induced by Mnl1 under weak acid stress; Spider biofilm repressed CAALFM_CR10260WA Putative mitochondrial 2' O-ribose methyltransferase; predicted role in methylation of U(2791) in 21S rRNA; Spider biofilm induced CAALFM_CR10270CA Putative Hsp90p co-chaperone; Hap43-repressed; heavy metal (cadmium) stress-induced; oxidative stress-induced via Cap1; rat catheter biofilm induced; flow model biofilm repressed CAALFM_CR10280WA Protein with a predicted role in cytochrome c oxidase assembly; rat catheter biofilm induced CAALFM_CR10290CA Ortholog(s) have Rab guanyl-nucleotide exchange factor activity CAALFM_CR10300WA Putative beta 2 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; Spider biofilm repressed CAALFM_CR10310WA Ortholog of C. dubliniensis CD36 : Cd36_35262, Candida tropicalis MYA-3404 : CTRG_05848 and Candida albicans WO-1 : CAWG_02290 CAALFM_CR10320WA Protein of unknown function; fluconazole-repressed; Spider biofilm induced CAALFM_CR10330WA Putative GPI-anchored protein CAALFM_CR10340WA Putative protein tyrosine phosphatase; hypha induced; alkaline induced; regulated by Efg1, Ras1, cAMP pathways; mutants are viable; Spider biofilm induced; rat catheter biofilm repressed; flow model biofilm repressed CAALFM_CR10350CA Thioredoxin; involved in response to reactive oxygen species; biofilm, benomyl, flucytosine, peroxide, Hap43 induced; amphotericin B, caspofungin repressed; induced by human neutrophils; macrophage-repressed gene CAALFM_CR10360CA Putative cytochrome c lysine methyltransferase; regulated by Gcn2 and Gcn4; transcript induced by Mnl1 under weak acid stress; early-stage flow model biofilm induced CAALFM_CR10370WA Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed CAALFM_CR10380CA Protein of unknown function; Hap43-induced gene; mutant is viable CAALFM_CR10390WA Protein involved in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport; putative subunit of the transport protein particle (TRAPP) complex of the cis-Golgi; Spider biofilm induced CAALFM_CR10400WA Ortholog(s) have peptide alpha-N-acetyltransferase activity, peptide-glutamate-N-acetyltransferase activity, peptide-serine-N-acetyltransferase activity CAALFM_CR10410CA Putative nucleolar protein with a predicted role in pre-18S rRNA processing; Plc1p-regulated; Spider biofilm induced CAALFM_CR10420WA Protein with a mitochondrial distribution and morphology domain; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced CAALFM_CR10430CA Ortholog(s) have ATPase activator activity, role in mRNA splicing, via spliceosome, positive regulation of ATPase activity and spliceosomal complex localization CAALFM_CR10440WA Putative subunit of an alternative replication factor C complex; role in DNA replication, genome integrity, homologous recombination-mediated repair and telomere homeostasis CAALFM_CR10450CA Functional homolog of S. cerevisiae Spt3p; required for virulence in mouse systemic infection; homozygous null mutant is hyperfilamentous CAALFM_CR10470CA Ortholog(s) have role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and 90S preribosome, nucleolus, small-subunit processome localization CAALFM_CR10480WA Putative GPI-anchored protein; induced during cell wall regeneration; required for normal adhesion to host cells and for adherence during Sabouraud biofilm formation; Spider biofilm induced CAALFM_CR10490WA Translation initiation factor eIF4E; genes encoding ribosomal subunits, translation factors, tRNA synthetases downregulated by phagocytosis by macrophage; alternatively spliced intron in 5' UTR; protein levels decrease in stationary phase CAALFM_CR10500CA Ortholog(s) have role in establishment of cell polarity, mycelium development, spore germination and endoplasmic reticulum, hyphal tip, mitochondrion, plasma membrane localization CAALFM_CR10510WA Ortholog(s) have role in positive regulation of TORC1 signaling and Seh1-associated complex, cytosol, extrinsic component of fungal-type vacuolar membrane, ribosome localization CAALFM_CR10520CA Putative GINS complex subunit; cell-cycle regulated periodic mRNA expression CAALFM_CR10530WA Ortholog of C. dubliniensis CD36 : Cd36_35360, C. parapsilosis CDC317 : CPAR2_200320, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136418 and Debaryomyces hansenii CBS767 : DEHA2A14080g CAALFM_CR10540CA Alpha-kleisin cohesin complex subunit; for sister chromatid cohesion in mitosis and meiosis; repressed by alpha pheromone in SpiderM medium; periodic cell-cycle expression; Hap43-repressed; rat catheter and Spider biofilm repressed CAALFM_CR10550WA Putative nucleolar DEAD-box protein; Hap43-induced; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); Tbf1-induced; repressed in core stress response CAALFM_CR10570CA Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; Hap43p-repressed gene CAALFM_CR10580WA Putative gamma-glutamyl kinase; transcript regulated by Nrg1; regulated by Gcn2 and Gcn4; Hap43-repressed gene; early-stage flow model biofilm induced gene CAALFM_CR10590WA Ortholog of S. cerevisiae Vps3; CORVET tethering complex component involved in vacuolar protein sorting; Hap43-repressed gene CAALFM_CR10600CA Ortholog(s) have 4-hydroxybenzoate octaprenyltransferase activity, role in ubiquinone biosynthetic process and integral component of mitochondrial membrane, mitochondrial inner membrane localization CAALFM_CR10610CA Ortholog(s) have ubiquitin-protein transferase activity, role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination and anaphase-promoting complex localization CAALFM_CR10620CA Biotin protein ligase; catalyzes covalent attachment of biotin to biotin-dependent enzymes including acetyl CoA carboxylase and pyruvate carboxylase CAALFM_CR10630WA Ortholog(s) have role in box C/D snoRNP assembly, protein folding, rRNA processing, regulation of cell size and R2TP complex, cytoplasm, nucleus, small nucleolar ribonucleoprotein complex localization CAALFM_CR10640WA Has domain(s) with predicted antiporter activity, drug transmembrane transporter activity, role in drug transmembrane transport and membrane localization CAALFM_CR10650WA Putative GSE complex component; repressed by prostaglandins CAALFM_CR10660WA Putative alpha subunit (catalytic subunit) of protein kinase CK2; Cka1p and Cka2p have a common target with respect to fluconazole resistance; synthetically lethal with CKA2; flucytosine induced CAALFM_CR10670WA Putative peptidyl-prolyl cis-trans isomerase; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm induced CAALFM_CR10680WA RNA polymerase II; ortholog of S. cerevisiae Rpo21, transposon mutation affects filamentous growth; flow model biofilm repressed CAALFM_CR10690WA Putative RNase MRP and nuclear RNase P component; decreased repressed by prostaglandins; Spider biofilm induced CAALFM_CR10700WA Putative heteropentameric replication factor C subunit; flucytosine induced; periodic mRNA expression, peak at cell-cycle G1/S phase CAALFM_CR10710CA Protein required for hyphal growth; has similarity to S. cerevisiae Vps52p CAALFM_CR10720WA ATP-dependent 3' - 5' helicase involved in maintenance of mitochondrial DNA; ortholog of S. cerevisiae Hmi1; rat catheter biofilm repressed CAALFM_CR10730CA Ortholog(s) have RNA polymerase II core binding activity and role in DNA damage response, detection of DNA damage, mRNA 3'-end processing, negative regulation of transposition, RNA-mediated CAALFM_CR10740WA Ortholog(s) have role in homologous chromosome segregation, protein localization to nucleolar rDNA repeats, rDNA condensation and monopolin complex, nuclear envelope, nucleolus localization CAALFM_CR10750CA Ortholog(s) have nucleolus localization CAALFM_CR10760CA Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrial inner membrane localization CAALFM_CR10770WA Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS) CAALFM_CR10780CA Protein similar to S. cerevisiae Iah1p, which is involved in acetate metabolism; mutation confers hypersensitivity to tunicamycin; transposon mutation affects filamentous growth CAALFM_CR10790WA Alpha-glucosidase; hydrolyzes sucrose for sucrose utilization; transcript regulated by Suc1, induced by maltose, repressed by glucose; Tn mutation affects filamentous growth; upregulated in RHE model; rat catheter and Spider biofilm induced CAALFM_CR10800CA Putative Ca2+/H+ antiporter; oral infection upregulated gene; mutants have reduced capacity to damage oral epithelial cells CAALFM_CR10810CA Ortholog(s) have role in ER-associated ubiquitin-dependent protein catabolic process, endoplasmic reticulum unfolded protein response CAALFM_CR10820WA Ortholog(s) have mRNA binding activity, role in mRNA splicing, via spliceosome and U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, commitment complex, cytosol localization CAALFM_CR10830CA Mitochondrial ribosomal protein of the large subunit; Spider biofilm repressed CAALFM_CR10840CA D-xylulose reductase; immunogenic in mice; soluble protein in hyphae; induced by caspofungin, fluconazole, Hog1 and during cell wall regeneration; Mnl1-induced in weak acid stress; stationary phase enriched; flow model biofilm induced CAALFM_CR10850CA Subunit of the mitochondrial F1F0 ATP synthase; sumoylation target; protein newly produced during adaptation to the serum; Spider biofilm repressed CAALFM_CR10860CA Putative transcription factor/activator; Med2 mediator complex ddomain; transcript is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes; Efg1, Hap43-repressed