-- dump date   	20250517_145553
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
An09g00010	Function: the S. cerevisiae Pad1p confers resistance to cinnamic acid.; Similarity: shows similarity to several phenylacrylic acid decarboxylase and 3-octaprenyl-4-hydroxybenzoate carboxy-lyase of different organisms.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae
An09g00030	Remark: the yigC protein of E. coli has been identified as the ubiD protein.; Title: similarity to ubiquinone biosynthesis protein ubiD - Escherichia coli; See PMID 11029449; See PMID 365223
An09g00050	Function: the enzyme CYP55A1 from F. oxysporum is involved in fungal denitrification, acting as a nitric oxide reductase.; Function: the expression of CYP55A1 from F. oxysporum is regulated in response to oxygen tension by an fumarate and nitrate reduction-like system.; Remark: ORF contains an internal stop codon, due to a putative point mutation.; Title: similarity to nitric-oxide cytochrome P-450 reductase Cyp55 - Fusarium oxysporum [putative sequencing error]; putative sequencing error; See PMID 2037602; See PMID 7798191; See PMID 9010754
An09g00060	Similarity: similarity to several hypothetical and known multidrug resistance proteins and ABC transporters of different organisms.; Title: similarity to multidrug resistance protein MLP-2 - Rattus norvegicus; See PMID 9614210; See PMID 10629898
An09g00070	Similarity: N-terminal half shows similarity to several transaminases of eukaryotes and bacteria.; Similarity: shows overall similarity to probable aminotransferases of N. crassa, S. cerevisiae and S. pombe.; Title: similarity to mitochondrial kynurenine aminotransferase KAT - Aedes aegypti; See PMID 12110301
An09g00100	Function: Sur1p of S. cerevisiae is required for mannosylation of sphingolipids.; Title: similarity to sphingolipid metabolism Sur1 -Saccharomyces cerevisiae
An09g00120	Alternative name: FAEA from A. niger was identical to A. niger FAE-III and is probably identical to ferA.; Function: involved in degradation of complex cell wall polysaccharides.; Gene-ID: faeA;ferA; Mapping: faeA from A. niger is mapped to chromosome I; see EMBL Y09330.; See PMID 9406381
An09g00150	Remark: blast hit not significant. ORF might be questionable.
An09g00160	Function: potential methyltransferase.; Similarity: shows similarity to hypothetical protein SPAC1B3. 06c of S. pombe, which belongs to the methyltransferase ubiE family.; Similarity: similiar proteins seem to be expressed in Streptomyces coelicolor and S. pombe.; Title: similarity to hypothetical protein Rv0839 -Mycobacterium tuberculosis
An09g00170	Catalytic activity: alpha-isopropylmalate synthase catalyzes the conversion of 3-Carboxy-3-hydroxy-4-methylpentanoate + CoA = Acetyl-CoA + 3-Methyl-2-oxobutanoate + H2O.; Function: alpha-isopropylmalate synthase catalyzes the first step in leucine biosynthesis pathway.; Remark: LEU4 of S. cerevisiae has the systematic name of YNL104C.; Remark: enzyme in S. cerevisiae shows alternative splicing but the putative protein in A. niger is shorter than the yeast short form.; Remark: the two alternatively spliced forms of LEU4 of S. cerevisiae code for the cytoplasmic and the mitochondrial forms of alpha-isopropylmalate synthase.; Title: strong similarity to alpha-isopropylmalate synthase Leu4 - Saccharomyces cerevisiae; See PMID 2420798
An09g00190	Localization: probable integral membrane protein.; Phenotype: null mutant QDR1 of S. cerevisiae is viable, but exhibits higher susceptibility to quinidine (SGD database).; Remark: the systematic name for QDR1 of S. cerevisiae is YIL120W.; Similarity: belongs to the CAR1/CYHR subfamily.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822
An09g00200	Remark: blast hits show weak similarity to partial sequence of oncogene 1 (tre-2 locus) (clone 210) and transforming protein (clone 213) - human.
An09g00210	Remark: blastp hit show very weak similarity to cytochrome P450 1A-61, polyaromatic hydrocarbon-inducible,hepatic - chicken.
An09g00220	Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Pathway: omtB of A. parasiticus is a component of the aflatoxin biosynthesis gene cluster.; Remark: aflatoxins are polyketide-derived secondary metabolites; Similarity: shows similarity to several fungal and bacterial O-methyl transferases.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10806361
An09g00230	Remark: blast hits result from similarities to the carboxyterminal part of O-methyltransferase B of Aspergillus spec.; Title: weak similarity to O-methyltransferase omtB -Aspergillus flavus; See PMID 10806361
An09g00250	Remark: similarity to domains of aldehyd dehydrogenases of various species - S. pombe, A. globiformis, E. coli. Sequence contains possible sequencing errors, bad quality sequence that might have affected the gene prediction.; Title: weak similarity to hypothetical aldehyde dehydrogenase CAB63554.1 - Schizosaccharomyces pombe
An09g00260	Catalytic activity: alpha-galactosidase catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.; Expression: expression of aglC was only observed on glucose, fructose, and combinations of glucose with xylose and galactose.; Gene-ID: aglC; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: partial CDS due to contig border, contains aminoterminus of algC, contig linked to contig An09c0030 but with a gap of about 200 bp,sequence ambiguities (contains N's) and possible sequencing errors (bad quality).; See PMID 10347026
An09g00270	Catalytic activity: alpha-galactosidase catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.; Expression: expression of aglC was only observed on glucose, fructose, and combinations of glucose with xylose and galactose.; Gene-ID: aglC; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: carboxyterminal part of algC.; Remark: linked to the adjacent contig An09c0020 but with a gap of about 200 bp, sequence ambiguities (contains N's),; Remark: partial CDS due to contig border.; See PMID 10347026
An09g00290	Title: weak similarity to hypothetical protein encoded by An03g03440 - Aspergillus niger
An09g00310	Catalytic activity: acid phosphatases catalyze the conversion of orthophosphoric monoester + H2O = alcohol + orthophosphate.; Similarity: shows similarity to several yeast acid phosphatases.; Title: similarity to constitutive acid phosphatase Ph03 - Saccharomyces cerevisiae; See PMID 6093051
An09g00360	Title: similarity to hypothetical protein encoded by An07g04880 - Aspergillus niger
An09g00380	Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Remark: ankyrins are a family of adapter molecules that mediate linkages between integral membrane and cytoskeletal proteins and are involved in distribution of membrane proteins in transporting epithelia.; Similarity: shows similarity to several ankyrin-repeat containing proteins of different organisms.; Title: weak similarity to ankyrin 3 (splice form 2) - Mus musculus
An09g00390	Remark: shows similarity to probable oxidoreductases of various bacteria (Streptomyces coelicolor, Pseudomonas aeruginosa, Neisseria meningitidis).; Title: similarity to hypothetical conserved protein PA2776 - Pseudomonas aeruginosa
An09g00400	Function: dicarboxylic amino-acid permease Dip5 of S. cerevisiae belongs to the DAACS family of transporters (TC 2. A. 23, Na+ or H+ symporter).; Remark: DIP5 of S. cerevisae has a systematic name of YPL265W.; Remark: possible sequencing error around pos. 21039 of the contig.; Remark: prnB of A. nidulans is part of the major proline transport system.; Similarity: shows also strong similarity to proline transporter prnB of A. nidulans and several other amino-acid transporter proteins of various organisms.; Title: strong similarity to dicarboxylic amino acid permease Dip5 - Saccharomyces cerevisiae; plasma membrane; putative frameshift; See PMID 8437566; See PMID 9508791; See PMID 2664423
An09g00420	Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide.; Remark: HADs belong to a large superfamily of hydrolases with diverse substrate specificity, which also includes epoxide hydrolases, phosphoglycolate phosphatases,histidinol phosphate phosphatases, nitrophenyl phosphatases and numerous putative (not yet characterised) proteins.; Similarity: 2-haloacid halidohydrolase IVa of B. cepacia belongs to the 2-haloalkanoid acid dehalogenases.; Title: similarity to 2-haloacid halidohydrolase IVa - Burkholderia cepacia; See PMID 1376111
An09g00430	Similarity: the PrnA protein of A. nidulans belongs to the Zn binuclear cluster family of transcriptional activators and is involved in proline utilization as a nitrogen and/or carbon source.; Similarity: the similarity spans only aa 14-640, the C-terminal part shows no similarity to prnA of A. nidulans.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360
An09g00440	Title: weak similarity to hypothetical protein encoded by An11g03090 - Aspergillus niger
An09g00450	Remark: LYS2 of S. cerevisiae has a systematic name of YBR115C.; Remark: shows better overall similarity to probable acyl-CoA synthase fadD9 of M. tuberculosis.; Similarity: similarity to S. cerevisiae LYS2 is restricted to C-terminal part.; Title: weak similarity to L-aminoadipate-semialdehyde dehydrogenase Lys2 -Saccharomyces cerevisiae
An09g00470	Similarity: shows weak similarity to proteins containing the abhydrolase domain of various species (H. sapiens, C. elegans, E. coli, M. tuberculosis).; Title: similarity to bladder tumour EST encoded protein 16 from patent DE19818619-A1 - Homo sapiens
An09g00480	Title: similarity to BCU0021 protein SEQ ID 8 from patent WO2003029421-A2 - Homo sapiens.
An09g00500	Function: ARG81 of S. cerevisiae is a regulator of arginine-responsive genes with ARG80 and ARG82; Remark: ARG81 of S. cerevisiae is also known as ARGR2 and has a systematic name of YML099C.; Similarity: shows matches only against the Zn(2)-Cys(6) motif of several hypothetical proteins and known transcription factors.; Title: weak similarity to transcription factor Arg81 - Saccharomyces cerevisiae
An09g00510	Title: strong similarity to hypothetical protein encoded by An01g01630 - Aspergillus niger
An09g00520	Function: the cyclic decapeptide antibiotic tyrocidine is produced by Bacillus brevis ATCC 8185 on an enzyme complex comprising three peptide synthetases, TycA,TycB, and TycC (tyrocidine synthetases 1, 2, and 3), via the nonribosomal pathway.; Similarity: shows similarity to internal part only.; Title: similarity to tyrocidine synthase 2 tycB -Brevibacillus brevis; See PMID 9352938
An09g00530	Function: the nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An09g00550	Function: S. pombe enzyme plays a role in the entry into G0, possibly by facilitating the release of a signaling substance into the environment as a means of cell-to-cell communication.; Remark: is longer than all other protein, might be due to sequencing error.; Similarity: fnx1(+) encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An09g00560	Function: enzyme of G. gallus catalyzes the hydroxylation of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 to 1,24, 25-trihydroxivitamin D3.; Title: similarity to mitochondrial 25-hydroxyvitamin D3 24-hydroxylase cP450cc24 - Gallus gallus; See PMID 9512657
An09g00570	Title: weak similarity to calcium binding protein P22 - Gallus gallus; See PMID 7769011
An09g00580	Function: those proteins are mostly involved in transcriptional control.; Similarity: shows similarity to proteins with zinc binuclear cluster homology.; Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An09g00590	Catalytic activity: converts salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida
An09g00600	Title: similarity to hypothetical hydroxylase snoaW - Streptomyces nogalater
An09g00610	Title: similarity to hypothetical protein SC6A5.32c - Streptomyces coelicolor
An09g00620	Function: 17 beta-hydroxysteroid dehydrogenase (17HSD) catalyzes the reversible conversion of estrone into estradiol.; Similarity: shows strong similarity to several short chain dehydrogenases, especially to estradiol 17beta-dehydrogenases (EC 1. 1. 1. 62).; Title: similarity to estradiol 17-beta-dehydrogenase HSD17B1 - Rattus norvegicus; See PMID 7925110
An09g00630	Title: strong similarity to hypothetical cipC -Aspergillus nidulans
An09g00640	Function: seems to be a general transcription factor.; Function: strains with the rco-1 mutant alleles were aconidial, female sterile, had reduced growth rates, and formed hyphae that coiled in a counterclockwise direction,opposite that of the wild type.; Similarity: shows only partial similarity to protein of N. crassa and several other proteins containing WD domains.; Title: similarity to transcription repressor RCO-1 -Neurospora crassa; nucleus; See PMID 8887652
An09g00650	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein F9K20.18 -Arabidopsis thaliana
An09g00660	Function: isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: isp4 of S. pombe was originally identified by subtractive screening as gene induced during the sexual differentiation process.; Similarity: the predicted A. niger protein shows strong similarity to protein isp4 of S. pombe, which belongs to the OPT subfamily of transporters specific for small oligopeptides (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe; plasma membrane; See PMID 9643541; See PMID 7954893
An09g00670	Function: a new family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases (Gelp), recently identified and characterized in the filamentous fungus Aspergillus fumigatus, showed functional similarity to the Gas/Phr/Epd protein families, which are involved in yeast morphogenesis.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 9430707
An09g00680	Title: strong similarity to hypothetical protein SC9B2.03 - Streptomyces coelicolor
An09g00690	Function: the P-type ATPase ENA1 mediates sodium and potassium effluxes in Schwanniomyces occidentalis.; Induction: the expression of ENA1 requires a high pH and the presence of Na+.; Title: strong similarity to P-type ATPase ENA1 -Schwanniomyces occidentalis; See PMID 9430707
An09g00700	Function: PepQ is a metalloprotease in Lactobacillus delbrueckii.; Title: similarity to X-Pro dipeptidase pepQ -Lactobacillus lactis; See PMID 9421914
An09g00710	Alternative name: fluoroacetate dehalogenase.; Catalytic activity: haloacetate + H(2)O = glycolate + halide.; Function: fluoroacetate dehalogenase catalyzes the dehalogenation of fluoroacetate and other haloacetates.; Remark: H-1 is encoded on the plasmid pUO1 from Moraxella sp. strain B.; Similarity: the deduced amino acid sequence of H-1 shows significant similarity to those of three hydrolases of Pseudomonas putida and a haloalkane dehalogenase of Xanthobacter autotrophicus.; Title: similarity to haloacetate dehalogenase H-1 -Moraxella sp.; See PMID 9812982; See PMID 1512562
An09g00720	Remark: questionable ORF due to the gene strukture.; Title: questionable ORF
An09g00770	Function: tto1 can transpose autonomously through reverse transcription.; Remark: tto1 uses a gene expression mechanism different from those employed by retroviruses and most retrotransposons in; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8522181
An09g00790	Catalytic activity: axe1 cleaves acetyl side chain groups from acetyl xylan.; Remark: acetyl xylan esterase axe1 of Trichoderma reesei contains an active-site serine residue and a C-terminal fungal cellulose-binding domain.; Remark: the AXE1 gene encodes 302 amino acids including a signal sequence and a putative propeptide.; Title: similarity to acetyl xylan esterase precursor axe1 - Trichoderma reesei; See PMID 8647098
An09g00800	Remark: N-terminally truncated due to contig border.; Title: similarity to zinc binuclear cluster protein sequence #31 from patent WO200224865-A2 - Unclassified organism
An09g00810	Similarity: shows similarity to several hypothetical oxidoreducatases.; Title: strong similarity to hypothetical zinc-binding oxidoreductase mll2116 - Mesorhizobium loti
An09g00820	Catalytic activity: chloride peroxidase catalyzes the conversion of 2 RH + 2 chloride + H2O2 = 2 RCl + 2 H2O.; Similarity: shows strong similarity to several bacterial known chloride and bromide peroxidases.; Title: strong similarity to chloride peroxidase est - Pseudomonas putida; See PMID 7670178; See PMID 11342031
An09g00830	Title: strong similarity to hypothetical protein BAC55926.1 - Acinetobacter calcoaceticus
An09g00840	Title: similarity to plastic-degradation enzyme within SEQ ID NO:6 from patent WO2004038016-A1 -Aspergillus oryzae
An09g00850	Remark: a putative sequencing error results in an frameshift.; Similarity: shows strong similarity to several ABC-type multidrug transporters of different specificities and of different species.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans [putative frameshift]; plasma membrane; putative frameshift; See PMID 9180695
An09g00860	Similarity: shows similarity to several known and hypothetical transcriptional activators, the similarity is restricted to the zinc finger domain.; Title: similarity to hypothetical transcription activator CAB59617.1 - Schizosaccharomyces pombe
An09g00870	Similarity: shows similarity to several known and hypothetical efflux transporters of different specificities of different species.; Title: strong similarity to aflatoxin efflux pump aflT - Aspergillus parasiticus; plasma membrane
An09g00880	Catalytic activity: hydrolysis of terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: acts only on small linear 1,5-alpha-linked l-arabinofuranosyl oligosaccharides.; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; Remark: also strong similarity to abf-A gene of A. niger patent EP506190-A.; Remark: arabinan-degrading enzymes and genes -isolated from fungi and having lower pH optima than arabinan-degrading enzymes of bacterial origin.; Remark: extra copies of abfA or abfB led to a decreased expression level of ABN A, though the repression elicited by abfB is stronger and more persistent than that effected by abfA. Multiple copies of both abf genes influence expression of the other ABF similarly, but to a far less pronounced degree than they affect ABN A synthesis. Four putative promoter elements, shared by all three arabinase genes, could be involved in coordination of L-arabinan degradation by A. niger.; Similarity: belongs to family 51 of glycosyl hydrolases.; Title: strong similarity to alpha-L-arabinofuranosidase A abfA - Aspergillus niger; See PMID 8000538
An09g00890	Catalytic activity: digallate + H2O = 2 gallate.; Remark: similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase also hydrolyses ester links in other tannins.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769
An09g00910	Remark: the ORF is short in length (83 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An09g00920	Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe
An09g00930	Catalytic activity: ATP + H2O = ADP + orthophosphate.; Function: this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na & K ions across the plasma membrane. This action creates the electrochemical gradient of Na & K, providing the energy for active transport of various nutrients.; Pathway: oxidative phosphorylation.; Remark: a putative sequencing error results in an frameshift.; Remark: also strong similarity to Rat (Na,K)-ATPase alpha 1 subunit gene coding region patent WO9855603-A1.; Remark: the ATPase gene appears to be present in one or very few copies in the rat and human genomes and to be transcriptionally regulated in different rat tissues.; Similarity: belongs to the cation transport ATPases family (e1-e2 ATPases).; Title: strong similarity to Na+/K+-exchanging ATPase alpha-1 chain NKAA1 - Rattus norvegicus [putative frameshift]; putative frameshift; See PMID 2166579; See PMID 2994074
An09g00950	Catalytic activity: release of an N-terminal D-Amino acid from a Peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-Amino acid amides and methyl esters also are hydrolysed, as is Clycine amide.; Remark: strong similarity to D-aminopeptidase gene in pC138K from Achromobacter sp. SCRC C1-38 patent JP03072887-A.; Remark: the enzyme appears to be a serine peptidase rather than a thiol one. The inhibition by PCMB in the wild-type enzyme may have been caused by a formation of a mercaptide bond between Cys 60 and PCMB. Considering that D-aminopeptidase, carboxypeptidase DD (a penicillin-binding protein), and beta-lactamase have a common feature in recognizing peptides containing D-amino acid and that the former two catalyze transpeptidation reactions with substrates containing D-alanyl-D-alanine moieties.; Similarity: belongs to the D-stereospecific aminopeptidases.; Title: strong similarity to D-stereospecific aminopeptidase dap - Ochrobactrum anthropi; See PMID 2760064; See PMID 1540587
An09g00960	putative sequencing error
An09g00980	Remark: Tto1 from Nicotiana tabacum can transpose autonomously through reverse transcription and the host factors required for transposition are conserved among monocots (class Magnoliopsida; rice) and dicots (class Liliopsida; tobacco), which diverged approximately 200 million years ago.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443
An09g01010	Catalytic activity: deacetylation of xylans and xylo-oligosaccharides.; Remark: the axe1 from T. reesei carries at its C-terminus a cellulose binding domain of fungal type, which is separated from the catalytic domain by a region rich in serine, glycine, threonine and proline. The binding domain can be separated from the catalytic domain by limited proteolysis without affecting the activity of the enzyme towards acetylated xylan, but abolishing its capability to bind cellulose.; Title: similarity to acetyl xylan esterase precursor axe1 - Trichoderma reesei; See PMID 8647098
An09g01020	Catalytic activity: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.; Pathway: arginine and proline metabolism; phenylalanine metabolism; tryptophan metabolism; cyanoamino acid metabolism; styrene degradation.; Remark: gene disruption experiments demonstrate that the resulting mutants show significantly reduced growth on acetamide-containing medium, indicating that the A. oryzae amdS gene encodes a functional acetamidase that is required for acetamide utilization.; Similarity: belongs to the amidase family.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 1840550
An09g01030	Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Remark: although A. parasiticus has an obligate growth requirement for oxygen, it produced ethanol in shake flask cultures indicating a response to anoxic conditions mediated by pyruvate decarboxylase.; Similarity: whith other enzymes which requires TTP; Title: strong similarity to pyruvate decarboxylase dcpY - Aspergillus parasiticus; See PMID 8181725
An09g01040	Remark: Kr2 transcripts of mouse can be detected in all the major structures of the developing nervous system during embryogenesis. The data are consistent with the hypothesis that mKr2 is a regulatory factor required for the differentiation and/or phenotypic maintenance of neurons.; Title: similarity to developmental control protein Kr2 - Mus musculus; See PMID 3409867; See PMID 3815523
An09g01050	Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycerol-3-phosphocholine + acetate.; Pathway: Glycerolipid metabolism.; Remark: purified PAF-acetylhydrolase, which converts PAF to an inactive metabolite, lysoPAF, from peritoneal fluid of guinea pigs subjected to experimental endotoxin shock and found that this purified enzyme had similar biochemical properties to the plasma enzyme.; Similarity: belongs to the family of hydrolases.; Title: similarity to platelet-activating factor-acetylhydrolase - Cavia porcellus; See PMID 8947850
An09g01070	Remark: strong similarity to patent WO0100842-A/419 from Corynebacterium glutamicum.; Remark: the sequence shows similarity to several nitrilotriacetate monooxygenases.; Title: strong similarity to protein from patent WO0100842-A - Corynebacterium glutamicum
An09g01080	Remark: LovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An09g01090	Function: MUP3 is a very low affinity methionine permease.; Remark: alternative name is YHL036w.; Remark: in mup1 mup3 double null mutants the methionine uptake is strongly inhibited by L-ethionine,L-leucine, L-histidine, L-threonine and L-phenylalanine.; Title: strong similarity to methionine uptake protein Mup3 - Saccharomyces cerevisiae; See PMID 8893857
An09g01100	Complex: S. lactamdurans 7 alpha-cephem-methoxylase two-protein component system formed by cmcI and cmcJ.; Function: S. lactamdurans cmcJ forms part of the 7 alpha-cephem-methoxylase which converts the antibiotic cephalosporin C to 7-methoxycephalosporin C.; Title: strong similarity to 7alpha-cephem-methoxylase subunit cmcJ - Streptomyces lactamdurans; See PMID 7721717
An09g01110	Similarity: the predicted A. niger protein shows weak similarity to a human cation transporter and contains a weak sugar transporter motif.; Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe
An09g01120	Remark: putative sequencing errors results in premature stop codons; Remark: the systematic name for S. cerevisiae Prm10 is YJL108c.; Title: strong similarity to cDNA of pheromone-regulated Prm10 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 11062271
An09g01130	Title: similarity to kprotein fragment SEQ ID NO:4711 from patent EP1108790-A2 - Corynebacterium glutamicum
An09g01140	Title: similarity to glucanase ZmGnsN3 from patent WO200073470-A2 - Zea mays
An09g01150	Function: mouse WOX1 is an enhancer of tumor necrosis factor (TNF) mediated apoptosis.; Function: upon TNF induced activation mouse WOX1 confers significant down-regulation of the apoptosis inhibitors Bcl-2 and Bcl-x(L) (>85%) and up-regulation of the pro-apoptotic p53 (approximately 200%) via its C-terminal alcohol dehydrogenase (ADH) domain.; Localization: mouse WOX1 is mainly located in the mitochondria and shows TNF-mediated WOX1 nuclear translocation.; Title: strong similarity to mitochondrial apoptogenic protein WOX1 - Mus musculus; localisation:mitochondrion; See PMID 11058590
An09g01160	Title: strong similarity to hypothetical protein SPBC409.17c - Schizosaccharomyces pombe
An09g01170	Function: rice ACC oxidase is involved in the formation of the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) from S-adenosylmethionine (AdoMet).; Remark: information concerning rice ACC oxidase is not available via PubMed and has been published by Cohen,E.; Kende, H. : In vivo 1-aminocyclopropane-1-carboxylate synthase activity in internodes of deepwater rice; Plant Physiol., 84; 282-286 (1987).; Title: similarity to 1-aminocyclopropane-1-carboxylate oxidase - Oryza sativa; See PMID 11031228
An09g01180	Title: weak similarity to hypothetical protein encoded by An11g08730 - Aspergillus niger
An09g01190	Catalytic activity: Arabinan endo-1,5-alpha-L-arabinosidases catalyse the endohydrolysis of 1,5-alpha-L-arabinofuranosidic linkages in 1,5-arabinans.; Function: A. niger abnA is involved in carbohydrate catabolism.; Gene-ID: abnA; See PMID 7764386
An09g01200	Remark: LYS14 of S. cerevisiae has a systematic name of YDR034C.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and S. cerevisiae Lys14.; Similarity: the predicted A. niger protein contains a N-terminalfungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus; See PMID 7935367
An09g01210	Function: E. chrysanthemi kduD is involved in pectin catabolism.; Title: strong similarity to 2-keto-3-deoxygluconate oxidoreductase kduD - Erwinia chrysanthemi; See PMID 3949717
An09g01220	Similarity: the ORF encoded protein shows also strong similarity to EST EMBLEST:BE760598 an_1942 from Aspergillus niger; Similarity: the predicted A. niger protein shows similarity to several hypothetical ATP/GTP binding proteins.; Title: similarity to hypothetical ATP/GTP-binding protein SCC61A.02 - Streptomyces coelicolor
An09g01230	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An09g01240	Function: P. notatum phospholipase B hydrolyzes both the acyl ester bonds of diacylphospholipids (diacyl-hydrolase) and the acyl ester bond of monoacylphospholipids or lysophospholipids.; Remark: A. niger lysophospholipase has been patented as Sequence 3 from Patent WO0127251.; Remark: P. notatum phospholipase B is a glycoprotein.; Title: strong similarity to phospholipase B -Penicillium notatum; See PMID 5402
An09g01250	Title: weak similarity to hypothetical protein encoded by An11g02890 - Aspergillus niger
An09g01260	Remark: aa sequence and possible function of human OXRD-1 where predicted from isolated Incyte clone 266711CD1.; Title: similarity to oxidoreductase OXRD-1 from patent WO200071679-A2 - Homo sapiens
An09g01270	Catalytic activity: RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein.; Function: YlALK1 functions to assimilate n-decane and longer molecules in Yarrowia lipolytica.; Induction: the expression of the P450 gene YlALK1 was induced by n-tetradecane and repressed by glycerol in Yarrowia lipolytica.; Remark: disruption of Yarrowia lipolytica gene ALK1 results in decreased n-decane assimilation.; Title: strong similarity to n-alkane inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 3892551; See PMID 9848230; See PMID 10953079
An09g01280	Remark: the predicted ORF contains an suboptimal long intron.; Title: questionable ORF
An09g01290	Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 11238987
An09g01300	Title: weak similarity to protein fragment SEQ ID NO:2141 from patent EP1033405-A2 - Arabidopsis thaliana
An09g01320	Function: A. oryzea mreA is an isoamyl alcohol oxidase; Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae
An09g01330	Function: S. cerevisiae ERG7 is responsible for the complex cyclization/rearrangement step in sterol biosynthesis.; Title: strong similarity to lanosterol synthase Erg7 - Saccharomyces cerevisiae; See PMID 7791529; See PMID 8134375
An09g01340	Catalytic activity: leukotriene-B4 20-monooxygenases convert 6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10, 14-tetraenoate + NADPH + O(2) to (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14 -tetraenoate + NADP(+) + H(2)O.; Function: human Cyp4F2 is involved in metabolisation of leukotriene B(4) (LTB(4)) to a less potent proinflammatory eicosanoid, 20-OH-LTB(4).; Localization: human Cyp4F2 was isolated from microsomes.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and human Cyp4F2.; Title: similarity to leukotriene B(4) omega-hydroxylase cytochrome P450 4F2 CYP4F2 - Homo sapiens; See PMID 10833273
An09g01350	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An09g01370	Catalytic activity: lignostilbene alpha beta-dioxygenases convert 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) to 2 vanillin.; Complex: P. paucimobilis LSD forms a heterodimer.; Function: P. paucimobilis LSD is responsible for the degradation of a diarylpropane-type structure in lignin-derived stilbenes.; Title: strong similarity to lignostilbene-alpha,beta-dioxygenase LSD - Pseudomonas paucimobilis; See PMID 7763879
An09g01380	Catalytic activity: vanillyl-alchool oxidase of P. simplicissimum and other organisms converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes.; Complex: vanillyl-alchool oxidase is a homooctamer.; Localization: in P. simplicissimum the enzyme is located both in the cytoplasm and in peroxisomes.; Title: strong similarity to vanillyl-alcohol oxidase vaoA - Penicillium simplicissimum; See PMID 8529652; See PMID 9013853; See PMID 9141139; See PMID 9261083; See PMID 1396672
An09g01390	Similarity: although some of the proteins showing weak similarity to the predicted ORF are annotated as transcription factor due to the presence of a Zn-2Cys-6 binuclear cluster, the predicted protein itself does not contain such domain.; Title: similarity to transcriptional activator Mut3 - Pichia angusta; See PMID 11126774
An09g01410	Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Remark: putative frameshift due to possible sequencing error at position 55431.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca [putative frameshift]; putative frameshift; See PMID 9501474; See PMID 9683653
An09g01420	Similarity: the C-terminal half of the predicted protein shows similarity to the N-terminal half of CAC3321 of C. acetobutylicum.; Title: similarity to hypothetical protein homolog of yveG CAC3321 - Clostridium acetobutylicum
An09g01430	Induction: the cDNA possibly encoding the AWI 31 protein is induced upon tissue wounding in A. thaliana.; Title: similarity to hypothetical induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278
An09g01440	Function: MAK1 the fungal pathogen N. haematococca encodes an FAD-dependent mono-oxygenase, known to specifically hydroxylate the phytoalexins medicarpin and maackiain, converting them to less fungitoxic derivatives.; Remark: medicarpin and maackiain are antifungal pterocarpan phytoalexins produced by many legumes, and are thought to be important components of the defense response of these legumes to certain fungal pathogens.; Similarity: the predicted ORF shows similarity to different known and putative monooxygenases and in particular to MAK1 of N. haematococca.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; See PMID 8709942; See PMID 11485199
An09g01450	Similarity: the predicted protein is very similar to the C-terminal half of CAC2826 of C. acetobutylicum.; Title: strong similarity to hypothetical intracellular protease/amidase related enzyme of the ThiJ family CAC2826 - Clostridium acetobutylicum
An09g01460	Title: strong similarity to hypothetical protein encoded by An03g03400 - Aspergillus niger
An09g01480	Title: strong similarity to hypothetical protein encoded by An03g03390 - Aspergillus niger
An09g01490	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein SPBC3H7. 05c from Schizosaccharomyces pombe; Similarity: the similarity to SPBC3H7. 05c of S. pombe is due to a very short, but well conserved, amino acid stretch.; Title: strong similarity to hypothetical protein EAA74627.1 - Gibberella zeae
An09g01500	Similarity: the predicted protein shows weaker similarity also to some proteins annotated as spliceosomal components.; Title: weak similarity to hypothetical protein B2O8.260 - Neurospora crassa
An09g01520	Remark: the F-box domain is present in numerous proteins and serves as a link between a target protein and a ubiquitin-conjugating enzyme.; Similarity: the similarity to human FBP-7 is due to the presence of an F-box domain.; Title: weak similarity to F-box protein FBP-7 from patent WO200012679-A1 - Homo sapiens
An09g01530	Function: there are no structural features, in the predicted protein, that can support a role as protease.; Title: weak similarity to precursor of IgA-specific metalloendopeptidase - Neisseria gonorrhoeae; See PMID 3027577
An09g01540	Similarity: the similarity to PPR1 of S. cerevisiae and other transcription factors is due to the presence of an N-terminal Zn-2Cys-6 binuclear cluster DNA-binding domain.; Title: weak similarity to transcription activator Ppr1 - Saccharomyces cerevisiae; See PMID 8668194; See PMID 9290251
An09g01550	Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Cofactor: copper and topaquinone.; Complex: AO-I of A. niger forms homodimers.; Gene-ID: AO-I; Induction: AO-I from A. niger is induced by N-butylamin.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: protein sequence PIR:S71320 is wrong, and it was updated by the same authors with sequences TREMBL:AF362473_1 and TREMBL:ANU31869_1.; Similarity: AO-I from A. niger belongs to a group of enzymes including those oxidizing primary monoamines,diamines and histamine.; Similarity: AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Similarity: in A. niger, a similar protein, called AO-II, is probably encoded by the same gene; it might represent a misfolded form of AO-I.; Similarity: two other ORFs show strong similarity to AO-I of A. niger.; cell wall; See PMID 7957232; See PMID 8598539; See PMID 8620882; See PMID 8679675; See PMID 8872745
An09g01560	Similarity: the predicted protein shows a much stronger similarity to hypothetical protein ORF1 of clone frb110/goh of Ustilago maydis.; Similarity: the similarity to b3Gal-T8 of H. sapiens is due to a very short, but very conserved, amino acid stretch.; Title: weak similarity to beta-1,3-galactosyltransferase b3Gal-T8 - Homo sapiens; See PMID 10580128
An09g01580	Similarity: the predicted protein does not contain a RING domain.; Similarity: the predicted protein shows stronger similarity to the A. fumigatus protein CAD29609. 1.; Title: weak similarity to RING finger protein rngB -Dictyostelium discoideum; See PMID 8647262
An09g01600	Similarity: the similarity to NMA1338 of N. meningitidis is due to a very short, but very conserved,amino acid stretch.; Title: weak similarity to hypothetical oxidoreductase NMA1338 - Neisseria meningitidis
An09g01620	Title: weak similarity to hypothetical protein encoded by An07g08820 - Aspergillus niger
An09g01630	Remark: the patent describes new secreted and transmembrane polypeptides and their polynucleotides,useful for treating blood coagulation disorders, cancers and cellular adhesion disorders.; Title: similarity to protein PRO706 from patent WO9946281-A2 - Homo sapiens
An09g01640	Similarity: other two A. niger ESTs, comprising part of the last exon and the 3'-UTR, confirm the expression of this ORF.; Similarity: the predicted ORF corresponds to A. niger EST EMBLEST:BE759892, comprising 5'-UTR, all the three exons and the 3'-UTR.; Title: strong similarity to EST an_2830 -Aspergillus niger
An09g01650	Similarity: in particular ORF10 of A. terreus lovastatin gene cluster and toxA of Cochliobolus carbonum might be involved in the efflux, respectively, of lovastatin A or HC-toxin produced by the two organisms.; Similarity: the predicted protein shows similarity to many hypothetical permeases of the major facilitator superfamily, mainly involved in multidrug transport.; Title: similarity to hypothetical membrane protein YMR088c - Saccharomyces cerevisiae; See PMID 8704997; See PMID 10334994
An09g01660	Title: strong similarity to hypothetical protein SPBC32F12.15 - Schizosaccharomyces pombe
An09g01670	Localization: HSP30 of N. crassa reversibly associates with mitochondria during heat shock.; Title: weak similarity to heat shock protein 30 hsp30 - Neurospora crassa; See PMID 2144284
An09g01680	Function: RTA1 of S. cerevisiae is involved in 7-aminocholesterol resistance.; Similarity: the predicted protein shows much stronger similarity to hypothetical proteins with unknown function.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An09g01690	Function: in C. carbonum, a fungal plant pathogen,HTS1 synthesizes HC-toxin, a cyclic tetrapeptide conferring the fungus exceptional virulence on certain genotypes of maize.; Similarity: NRPSs have a modular architecture, where a module is the catalytic unit that incorporate a specific amino acid into the growing chain; each module is composed at least by three different domains: an adenylation domain, a 4'-phosphopantetheine attachment domain (peptidyl carrier) and a condensation domain.; Similarity: in the predicted ORF at least two modules are present, and are characterized by the three described domains.; Similarity: the predicted ORF shows strong similarity to several non-ribosomal peptide synthetases (NRPSs), a class of multifunctional enzymes required for the biosynthesis of a variety of biologically relevant peptide compounds.; Title: strong similarity to HC-toxin synthase HTS1 -Cochliobolus carbonum; See PMID 9756477; See PMID 10811885; See PMID 1281482
An09g01700	Function: MRP1 of H. sapiens and mouse may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.; Similarity: MRP1 of H. sapiens belongs to the ATP-binding transport protein family (ABC transporters),and belongs to the MDR (multidrug resistance) subfamily.; Title: strong similarity to multidrug resistance protein MRP1 - Homo sapiens; plasma membrane; See PMID 8098549; See PMID 8649356; See PMID 1360704
An09g01710	Catalytic activity: epoxide hydrolases catalyze the hydrolysis of an epoxide to a glycol.; Similarity: although the similarity to echA of A. tumefaciens is weak, several other hypothetical protein homologues and some structural feature suggest that the predicted protein could act as a hydrolase, and maybe as an epoxide hydrolase.; Title: similarity to epoxide hydrolase from patent EP879890-A - grobacterium radiobacter
An09g01740	Catalytic activity: FAS1 of S. cerevisiae is a pentafunctional enzyme consisting of the following domains : acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase.; Function: FAS1 of S. cerevisiae catalyzes the formation of long-chain fatty acids from acetyl-CoA,malonyl-CoA and NADPH, and is therefore necessary for fatty acid biosynthesis.; Remark: C-terminally truncated ORF due to contig border.; Similarity: the predicted protein is also very similar to FasB, the fatty acid synthase of E. nidulans.; Title: strong similarity to beta chain of fatty-acyl-CoA synthase Fas1 - Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 3528750; See PMID 6311818; See PMID 6330502; See PMID 810348; See PMID 1107031
An09g01750	Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH <=> a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans [truncated ORF]; See PMID 8848053; See PMID 8962148
An09g01760	Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae
An09g01790	Title: strong similarity to hypothetical protein AAD34553.1 - Aspergillus terreus
An09g01800	Function: the trichothecene 3-O-acetyltransferase TRI101 from F. sporotrichioides converts isotrichodermol to isotrichodermin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Pathway: F. sporotrichioides TRI101 is required for the biosynthesis of T-2 toxin.; Remark: Fusarium and related fungi produce trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973
An09g01810	Function: enzyme is capable of reducing a variety of alpha-ketolactones, alpha-ketolactams and diketones.; Title: strong similarity to ketoreductase from patent EP918090-A - Saccharomyces cerevisiae; See PMID 10951208
An09g01820	Catalytic activity: 4-coumarate-CoA ligase catalyzes the conversion of ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.; Function: key enzyme of phenylpropanoid metabolism.; Pathway: phenylpropanoid biosynthesis.; Title: strong similarity to 4-coumarate-CoA ligase 4CL - Arabidopsis thaliana; See PMID 7640359
An09g01830	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD flavoprotein.; Function: catalyzes the oxygen-dependent degradation of 6-hydroxynicotine into 6-hydroxypyrid-N-methylosmine.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516; See PMID 3905431; See PMID 2115879
An09g01840	Catalytic activity: salicylate + NADH + H(+) + O(2) = chatechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD flavoprotein.; Function: salicylate 1-monooxygenase catalyzes the formation of catechol from salicylate.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida
An09g01850	Catalytic activity: benzoate 4-monooxygenases convert benzoate + NADPH(2) + O(2) to 4-hydroxybenzoate + NADP + H(2)O.; Function: in A. niger bphA and cprA are the two cytochrome P450s required for the para-hydroxylation of benzoate.; Induction: A. niger bphA is inducible by benzoate.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 10852481
An09g01860	Function: required for conidial pigmentation in A. fumigatus.; Pathway: involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase wA -Aspergillus nidulans
An09g01870	Title: similarity to hypothetical binuclear zinc transcription factor PRF - Nectria haematococca
An09g01880	Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC from A. terreus is an accessory protein that modulates polyketide synthase activity during lovastatin biosynthesis.; Remark: it is assumed, that the ORF is encoded in a polyketide biosynthesis gene cluster, as proximal sequences encode homologues of further proteins for lovastatin synthesis (lovF of A. terreus and alb1 of A. fumigatus).; Similarity: the ORF shows similarity to several oxidoreductases, some of the known are quinone oxidoreductases or/and involved in toxin biosynthesis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An09g01900	Title: similarity to hypothetical protein mlr5144 -Mesorhizobium loti
An09g01910	Function: TetA of A. tumefaciens C58 confers resistance to tetracyclin and some of it's derivatives.; Repression: TetA expression in A. tumefaciens C58 is repressed by the transcriptional regulator TetR.; Title: similarity to tetracyclin resistance protein tetA - Agrobacterium tumefaciens; See PMID 9882678
An09g01920	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD flavoprotein.; Function: catalyzes the oxygen-dependent degradation of 6-hydroxynicotine into 6-hydroxypyrid-N-methylosmine.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516; See PMID 3905431; See PMID 2115879
An09g01930	Function: lovF from A. terreus specifies formation of 2-methylbutyrate.; Remark: it is assumed, that the ORF is encoded in a polyketide biosynthesis gene cluster, as proximal sequences encode homologues of further proteins for lovastatin synthesis (lovC of A. terreus and alb1 of A. fumigatus).; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10381407; See PMID 11375168; See PMID 11386351; See PMID 11412974
An09g01940	Function: involved in 7-aminocholesterol resistance; 7-aminocholesterol is a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae
An09g01950	Function: catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: trichothecene bioynthesis; trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: belong to the cytochrome P450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An09g01970	Title: similarity to oxidoreductase from patent WO0100844 - Corynebacterium glutamicum
An09g01990	Catalytic activity: branched-chain amino acid + 2-oxoglutarate = corresponding keto acid + L-glutamate.; Cofactor: pyridoxal-phosphate.; Function: catalyzes the first reaction in the catabolism of L-isoleucine, L-leucine, L-valine and L-methionine.; Title: strong similarity to branched-chain amino acid aminotransferase bcaT - Lactococcus lactis; See PMID 10831406
An09g02000	Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.; Cofactor: heme-thiolate.; Title: strong similarity to cytochrome P450 -Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702
An09g02010	Catalytic activity: acetyl-CoA+N malonyl-CoA+2N NADPH <=> a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Phenotype: A. nidulans mutant for fasA are unable to grow on minimal medium unless supplemented with myristic acid.; Title: strong similarity to fatty acid synthase alpha subunit fasA - Aspergillus nidulans; See PMID 8848053; See PMID 8962148
An09g02020	Function: the molecular function of MxA remains elusive, although its antiviral activities are well recognized.; Induction: MxA (also known as Mx1 or p78) is a mammalian protein induced by Interferon- alpha and beta,and to much less extent by Interferon-gamma.; Similarity: MxA of H. sapiens and the predicted ORF contain dynamin domains; all dynamins, comprising human MxA, hydrolyse GTP.; Title: strong similarity to interferon-regulated resistance GTP-binding protein MxA - Homo sapiens; See PMID 2607176; See PMID 10702310; See PMID 2154602; See PMID 2161946; See PMID 2481229
An09g02040	Title: strong similarity to hypothetical protein slr1870 - Synechocystis sp.
An09g02050	Pathway: the two enzymes catalyze two slightly different reactions within the butanoate metabolism.; Similarity: the predicted protein shows strong similarity both to mammalian peroxisomal enoyl-CoA hydratase (EC 4. 2. 1. 17), and to bacterial 3-hydroxybutryl-CoA dehydratase (EC 4. 2. 1. 55).; Title: strong similarity to 3-hydroxybutryl-CoA dehydratase crt - Clostridium acetobutylicum; See PMID 5057466; See PMID 8655474
An09g02060	Similarity: although the length of the predicted ORF is very different from other cholesterol oxidases, and the C- terminal is not conserved, some structural domains suggest that it might have some oxidase activity.; Similarity: the ORF encoded protein shows also weak similarity to putative cholesterol oxidase choD from Mycobacterium leprae.; Similarity: the similarity to choD and other cholesterol oxidases is stronger in the N-terminal part of the molecule.; Title: strong similarity to hypothetical protein CAD21388.1 - Neurospora crassa
An09g02080	Remark: the transposable element Tan1 in A. niger has a structure like IR-ORF-IR-IR-Vader-IR, where IR means Inverted Repeat, Vader is an inactive transposable element,present in approximately 15 copoies in the genome, and the unique ORF encodes a putative transposase homologous to Fusarium oxysporum Fot1 and Magnaporthe grisea Pot2.; Title: strong similarity to transposase Tan1 -Aspergillus niger; See PMID 9003286
An09g02090	Title: weak similarity to hypothetical protein encoded by An12g05320 - Aspergillus niger
An09g02100	Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to many described or hypothetical polyketide syntases.; Title: strong similarity to polyketide synthase nysI - Streptomyces noursei; See PMID 10873841
An09g02110	Title: questionable ORF
An09g02120	Similarity: the N-terminal part of the predicted ORF shows indeed a good similarity to the isochorismatase family of hydrolase enzymes.; Similarity: the N-terminal region of the predicted ORF shows some similarity to putative proteins similar to pyrazinamidase/nicotinamidase; the similarity to hypothetical protein PA3306 of P. aeruginosa involves a 200 amino acids-long stretch in the central part of the predicted protein.; Title: similarity to hypothetical protein PA3306 -Pseudomonas aeruginosa
An09g02130	Similarity: some similarity with a short stretch of a hypothetical O-succinylhomoserine sulfhydrylase of Mycobacterium leprae.
An09g02150	Function: paxM of P. paxilli is comprised within an indole-diterpene gene cluster, but its function is putatively induced by homology.; Similarity: the predicted ORF shows similarity to different, mainly putative, monooxygenases.; Title: strong similarity to hypothetical monooxygenase paxM - Penicillium paxilli; See PMID 11169115
An09g02160	Catalytic activity: deacetylation of rhamnogalacturonan.; Function: rhamnogalacturonan acetylesterase acts in synergy with rhamnogalacturonase A as well as rhamnogalacturonase B from A. aculeatus in the degradation of apple pectin rhamnogalacturonan.; Gene-ID: rgaeA; Induction: the expression of rhamnogalacturonan degrading enzymes by A. acculeatus is regulated at the level of transcription and is subjected to carbon catabolite repression by glucose.; Similarity: the predicted ORF is about 70% identical to the biochemically characterized rhamnogalacturonan acetylesterase of A. aculeatus, which was therefore used for annotation.; Similarity: the predicted ORF is identical to the cloned A. niger gene; the enzymatic characterization of this gene has not been published.; See PMID 7592973
An09g02170	Title: weak similarity to precursor of pertussis toxin chain S3 - Bordetella pertussis; See PMID 3704651
An09g02180	Similarity: A. niger EST EMBLEST:BE760925 covers part of the last exon and part of the putative 3'UTR of the gene.; Title: strong similarity to phospholipase A1 from patent JP10155493-A - Aspergillus oryzae; See PMID 2253331
An09g02200	Title: questionable ORF
An09g02210	Similarity: the patented protein from A. chrysogenum is involved in biosynthesis of cephalosporin C and can be used to improve the fermentation ability of Acremonium chrysogenum.; Similarity: the predicted ORF also shows significant similarity to many putative or described membrane transporters.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An09g02220	Function: human Rev1 transferase may play a critical role during mutagenic translesion DNA synthesis bypassing a template AP site in human cells.; Function: the human Rev1 protein is a dCMP transferase that specifically inserts a dCMP residue opposite to a DNA template G or to a uracile residue, or to an apurinic/apyrimidinic (AP) site.; Similarity: the Rev1 protein of H. sapiens is a member of the family of translesion DNA polymerases.; Title: strong similarity to deoxycytidyl transferase Rev1 - Homo sapiens; See PMID 10536157; See PMID 11278384
An09g02230	Similarity: the predicted ORF contains domains conserved in protein families with unknown function (see PFAM and BLOCKS).; Title: similarity to hypothetical protein BAA10688.1 - Synechocystis sp.
An09g02240	Remark: in the literature (see citations) there are two reports of N-acetyl-beta-D-glucosaminidases, extracted respectively from A. niger and A. nidulans, which were extensively biochemically characterized.; Remark: unfortunately the two enzymes were not cloned; the pI of the enzymes corresponds to the one calculated for the predicted ORF; the difference in MW could be explained either by polymerization or extensive glycosilation.; Similarity: the predicted ORF is almost identical to A. nidulans nagA gene, coding for an N-acetyl-beta-D-glucosaminidase (unpublished).; Title: strong similarity to beta-N-acetylhexosaminidase from patent WO9839459-A1 -Penicillium chrysogenum; See PMID 2693201; See PMID 9428156
An09g02250	Function: RAD5 of S. cerevisiae has single-stranded DNA-dependent ATPase activity, and is involved in error-free DNA repair.; Remark: RAD5 of S. cerevisiae is also called REV2,SNM2 or YLR032W.; Similarity: A. niger EST EMBLEST:BE76059 covers the last part of the reading frame and part of the putative 3'UTR.; Similarity: the predicted ORF shows equally strong similarity to the S. cerevisiae RAD5 protein, and its homologue Rad8 of S. pombe.; Title: strong similarity to DNA repair protein Rad5 - Saccharomyces cerevisiae; nucleus; See PMID 8290359; See PMID 9016623; See PMID 9637242; See PMID 10430580; See PMID 1324406
An09g02260	Function: hapE of P. fluorescens catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate.; Remark: closest manual homologue (BLASTP) is TREMBL:AF355751_1.; Similarity: the predicted ORF shows moderate similarity to several hypothetical and known monooxygenases with different specificity.; Title: similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873
An09g02270	Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate, and diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; extracellular/secretion proteins; See PMID 7578238; See PMID 8306978
An09g02280	Function: PRP4 of S. cerevisiae is necessary for spliceosome assembly and for splicing of pre-mRNA.; Remark: PRP4 of S. cerevisiae is also known as RNA4 or YPR178w.; Similarity: the similarity to PRP4 of S. cerevisiae involves only the N-terminal half of the predicted protein.; Title: similarity to U4/U6 snRNP 52kD protein Prp4 -Saccharomyces cerevisiae; See PMID 2528686; See PMID 3322934; See PMID 6094499; See PMID 7050675; See PMID 342911
An09g02290	Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n =UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)](n+1).; Function: chitin synthase chsE of A. nidulans plays a major role in cell wall biogenesis.; Similarity: chsE of A. nidulans belongs to the chitin synthase class IV subfamily.; Title: strong similarity to chitin synthase chsE -Aspergillus nidulans; See PMID 8810520
An09g02320	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: the A. niger protein is 250 amino acids shorter than PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g02330	Title: weak similarity to hydrolase protein YODH from patent WO9927081-A2 - Bacillus subtilis
An09g02340	Function: phosphatidylethanolamine binding protein D1 is thought to play a role in transport or signal mechanisms between membranes and the cytoplasm.; Phenotype: in wild-type 'indeterminate' tomato plants, inflorescences are separated by three vegetative nodes. In 'determinate' plants homozygous for the recessive allele of the SELF-PRUNING (SP) gene, sympodial segments develop progressively fewer nodes until the shoot is terminated by two consecutive inflorescences.; Similarity: the A. niger protein also shows similarity to the hypothetical phosphatidylethanolamine binding protein D1 Ovd1 of Onchocerca volvulus and contains corresponding PFAM and BLOCKS domains.; Title: similarity to self-pruning protein SP -Lycopersicon esculentum; See PMID 9570763
An09g02370	Function: SlpE of S. lividans is required for growth on minimal media.; Title: similarity to proteinase SlpE - Streptomyces lividans; See PMID 7592364
An09g02380	Title: similarity to hypothetical protein CG17807 -Drosophila melanogaster
An09g02390	Catalytic activity: AAT2 of S. cerevisiae catalyzes L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Similarity: AAT2 of S. cerevisiae belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to aspartate aminotransferase Aat2 - Saccharomyces cerevisiae; See PMID 1859361; See PMID 9655342
An09g02410	Remark: chip3 was found in a differential-display for the isolation of genes required for the differentiation into an infection structure called the appressorium.; Title: similarity to hard surface induced protein 3 chip3 - Glomerella cingulata; See PMID 10940006
An09g02430	Title: similarity to esterase EST2 - Acetobacter pasteurianus
An09g02440	Function: the homoprotocatechuic acid (HPC) pathway is a typical catabolic sequence for converting peripheral metabolites into intermediates of central metabolism.; Pathway: hpcH is involved in the meta-fission pathway for homoprotocatechuic acid (HPC) catabolism.; Title: strong similarity to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase hpcH -Escherichia coli; See PMID 8529896
An09g02460	Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Remark: the N-term and the C-term of the A. niger protein show similarity to the C-term of dotA.; Title: similarity to inhibitor of endosome-lysosome fusion dlpA - Legionella pneumophila; endosome; See PMID 11207624; See PMID 9632267
An09g02470	Title: similarity to protein fragment SEQ ID NO:24319 from patent EP1033405-A2 - Arabidopsis thaliana
An09g02490	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Remark: the A. niger protein is C-terminally truncated due to the end of the contig.; Similarity: FLU1 of C. albicans is a member of the major falicitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [truncated ORF]; See PMID 11065353
An09g02500	Title: weak similarity to hypothetical adult male testis cDNA clone:4933407G07 - Mus musculus
An09g02510	Remark: the A. niger protein also shows strong similarity to mouse mpv17 protein, disruption of which leads to nephrotic syndrome and chronic renal failure.; Remark: the A. niger protein also shows strong similarity to mouse peroxisomal membrane protein PMP22. The molecular functions of PMP22 and mpv17 are not known.; Title: strong similarity to hypothetical membrane protein YLR251w - Saccharomyces cerevisiae
An09g02520	Similarity: the A. niger protein shows weak similarity to many different protein kinases and contains a PFAM kinase domain.; Title: weak similarity to stress activated protein kinase JNK3 - Rattus norvegicus; deleted EC_number 2.7.1.37
An09g02530	Title: strong similarity to hypothetical protein EAA60542.1 - Aspergillus nidulans
An09g02540	Title: similarity to hypothetical membrane protein YIL067c - Saccharomyces cerevisiae
An09g02550	Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An09g02560	Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: polyamine oxidase catalyses the oxidation of the secondary amino group of spermine, spermidine and their acetyl derivatives. The enzyme plays an important role in the regulation of polyamine intracellular concentration and is a member of the family of flavin-containing amine oxidases.; Similarity: belongs to amine oxidase (flavin-containing) proteins.; Title: similarity to polyamine oxidase PAO - Zea mays; See PMID 9598979; See PMID 10089528
An09g02580	Function: YHR gene confers resistance to cycloheximide.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An09g02590	Function: required for the conversion of versicolorin to sterigmatocystin.; Pathway: sterigmatocystin biosynthesis.; Remark: stcS of A. nidulans is also called verB,stcF, cyp59A1, cyp59, or cyp60A2.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 7486998; See PMID 10618248
An09g02610	Catalytic activity: 2-trans,6-trans-farnesyl diphosphate = trichodiene + pyrophosphate.; Function: trichodiene synthase catalyzes the isomerization and cyclization of farnesyl pyrophosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes; it serves to branch trichothecene biosynthesis from the isoprenoid pathway.; Title: similarity to trichodiene synthase -Gibberella pulicaris; See PMID 1421511
An09g02620	Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; See PMID 8163491
An09g02630	Title: questionable ORF
An09g02650	Function: BiP of O. sativa is involved in protein folding and assembling/disassembling of protein complexes.; Title: weak similarity to dnaK-type molecular chaperone BiP - Oryza sativa; endoplasmatic reticulum; See PMID 9177027
An09g02670	Title: questionable ORF
An09g02700	Catalytic activity: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO(2).; Cofactor: thiamine pyrophosphate.; Complex: heterodimer of an alpha and a beta chain.; Function: the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2); it contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).; Title: strong similarity to branched-chain alpha-keto acid dehydrogenase E1 alpha subunit BCHEL1 -Homo sapiens; localisation:mitochondrion; See PMID 2703538; See PMID 2914958; See PMID 3224821; See PMID 8037208
An09g02710	Catalytic activity: acetyl-CoA + dihydrolipoamide <=> CoA + S-acetyldihydrolipoamide.; Cofactor: lipoyl group.; Complex: component of multienzyme pyruvate dehydrogenase complex.; Function: the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).; Title: strong similarity to branched-chain alpha-keto acid dihydrolipoyl acyltransferase - Gallus gallus; localisation:mitochondrion; See PMID 11168412
An09g02720	Remark: STR1 (suppressor of telomeric repression-1) is a telomerase-associated protein found in conjunction with S. cerevisiae telomerase, a ribonucleoprotein required for telomere replication.; Title: strong similarity to STR1 protein from patent WO9612811-A2 - Saccharomyces cerevisiae
An09g02730	Complex: heterodimer of two subunits (IMP1 and IMP2).; Function: Known to process the nuclear encoded CYT-B2, the mitochondrially encoded COX2 and cyctochrome C1.; Function: Required for the stability of IMP1.; Function: catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.; Title: strong similarity to inner membrane protease I chain 2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8132591; See PMID 8266095
An09g02740	Title: strong similarity to hypothetical protein SPAC26H5.11 - Schizosaccharomyces pombe
An09g02770	Remark: protein is essential for the formation of gamma tubulin ring complex.; Title: similarity to gamma tubulin ring protein GRIP210 - Xenopus laevis; See PMID 11134080
An09g02780	Title: similarity to myosin heavy chain - Gallus gallus; See PMID 2892941; See PMID 3312184; See PMID 194651
An09g02790	Catalytic activity: TRI101 of F. sporotrichioides catalyzes O-acetylation of the trichothecene ring specifically at the C-3 position in an acetyl-CoA-dependent manner.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of T-2 toxin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Remark: trichothecenes like T-2 toxin or 4,15-diacetoxyscirpenol are sesquiterpenoid mycotoxins. They act as potent protein synthesis inhibitors for eukaryotic organisms, and are produced by different fungal genera,including Fusarium.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; See PMID 10960733
An09g02800	Catalytic activity: Acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine.; Remark: the A. nidulans cysA gene shows extensive similarity to bacterial homoserine O:-acetyltransferases.; Title: strong similarity to serine O-acetyltransferase cysA - Aspergillus nidulans; plasma membrane; See PMID 11021945
An09g02810	Title: weak similarity to nuclear mitotic apparatus protein NuMA - Homo sapiens; See PMID 541636; See PMID 1541630
An09g02820	Function: the RAD4 gene product of S. cerevisiae is required for the incision step of excision repair of DNA damaged by UV and by other agents that distort the DNA helix.; Title: strong similarity to excision repair protein Rad4 - Saccharomyces cerevisiae; nucleus; See PMID 2649477; See PMID 2822652; See PMID 3073107
An09g02830	Catalytic activity: Acylaminoacyl-peptide + H(2)O = acylamino acid + peptide.; Function: the A. fumigatus homolog DPPV is a secreted dipeptidyl-peptidase.; Title: strong similarity to acylaminoacyl-peptidase DPP V - Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9045640; See PMID 9234752
An09g02840	Title: strong similarity to hypothetical protein EAA65458.1 - Aspergillus nidulans
An09g02850	Similarity: similarities correspond to multiple asparagine and proline repeats.; Title: weak similarity to hypothetical sporozoite surface protein 2 - Plasmodium yoelii
An09g02860	Title: weak similarity to DNA topoisomerase top1 -Cricetulus griseus; See PMID 8244980; See PMID 1312902
An09g02870	Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Title: similarity to transcription activator prnA -Aspergillus nidulans; nucleus; See PMID 2668692; See PMID 9622360; See PMID 10788322
An09g02880	Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe
An09g02890	Title: similarity to hypothetical protein orf-223 -Lactobacillus helveticus
An09g02900	Function: the VRP1 gene product of S. cerevisiae acts in both actomyosin ring formation and function as well as in Hof1p localization during cytokinesis.; Remark: the VRP1 gene product of S. cerevisiae binds an SH3-domain-containing fragment of Hof1p, which encodes a protein related to mammalian proline serine threonine phosphatase-interacting protein and S. pombe Cdc15p required for an actomyosin ring-independent pathway of cytokinesis in S. cerevisiae.; Title: similarity to verprolin Vrp1 - Saccharomyces cerevisiae; See PMID 7968536; See PMID 10931290; See PMID 11260524
An09g02910	Induction: the S. cerevisiae ATR1 transcription is induced by aminotriazole, and the ATR1 promoter region contains a binding site for the GCN4 activator protein.; Title: similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 2123132
An09g02920	Title: similarity to hypothetical protein 260 -Methanothermus fervidus
An09g02930	Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An09g02960	Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa
An09g02970	Title: questionable ORF
An09g02980	Catalytic activity: 2 catechol + O(2) = 2 1,2-benzoquinone + 2 H(2)O.; Remark: patentmatch against polyphenol oxidase PPO W09421 Geneseqprot.; Title: similarity to polyphenol oxidase PPO from patent WO9637617-A1 - Lactuca sativa
An09g02990	Title: similarity to hypothetical Sua5 protein APE2397 - Aeropyrum pernix
An09g03000	Title: weak similarity to hypothetical plenty-of-prolines-101 protein POP101 - Mus musculus
An09g03010	Remark: The EST sequence is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to EST an_2241 -Aspergillus niger
An09g03020	Function: the Aspergillus nidulans complex locus,cnxABC, has been shown to be required for the synthesis of precursor Z, an intermediate in the molybdopterin cofactor pathway.; Induction: transcription of the cnxABC locus is subject to nitrate induction.; Remark: cnxABC is a difunctional protein with two catalytic domains, CnxA and CnxC.; Remark: the molybdopterin cofactor is required for the activity of the molybdoenzyme nitrate reductase.; Similarity: the CnxA domain is similar at the amino acid level to the Escherichia coli moaA gene product, while CnxC is similar to the E. coli moaC product, with both E. coli products encoded by different cistrons.; Title: similarity to molybdopterin cofactor biosynthetic protein cnxABC - Aspergillus nidulans; See PMID 9353296
An09g03030	Catalytic activity: ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + phosphate + glutathione.; Pathway: GSH2 catalyzes the second step in glutathione biosynthesis.; Remark: Glutathione (GSH) is important for the detoxification of harmful intermediates that are generated during normal cellular metabolism.; Title: strong similarity to glutathione synthase Gsh2 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 9307967; See PMID 9512666
An09g03040	Title: weak similarity to hypothetical protein CAE76587.1 - Neurospora crassa
An09g03050	Title: similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An09g03060	Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.; Function: carbonic anhydrase beta-CA1 catalyzes the reversible hydration of CO2, a reaction that is important in many physiological processes.; Title: strong similarity to beta-type carbonic anhydrase beta-CA1 - Coccomyxa sp.; See PMID 9701590
An09g03070	Function: mok1 plays an essential role for cell morphogenesis.; Induction: alpha-glucan biosynthesis is regulated in a signaling pathway in which the Rho2p GTPase activates Pck2p, and this kinase in turn controls mok1.; Localization: mok1 localizes closely with the actin cytoskeleton.; Localization: the myosin Myo52 partially colocalises with the alpha-glucan synthase mok1 at the cell tips and to a lesser extent at the septum.; Title: strong similarity to alpha-glucan synthase mok1p - Schizosaccharomyces pombe; See PMID 11102532; See PMID 11112691
An09g03090	Remark: similarity is due to glutamate-rich region of the protein.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens
An09g03100	Catalytic activity: AmyA catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Remark: AmyA requires for its activity the binding of the cofactor calcium.; Title: strong similarity to alpha-amylase precursor amy - Aspergillus niger; extracellular/secretion proteins; See PMID 2340591
An09g03110	Catalytic activity: AMY catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Remark: Bacillus amyloliquefaciens alpha-amylase AMY is commercially supplied as 'Bacillus subtilis alpha-amylase'.; Title: strong similarity to alpha-amylase precursor amy - Bacillus amyloliquefaciens; extracellular/secretion proteins; See PMID 2830166; See PMID 6156671
An09g03120	Title: similarity to hypothetical serine-rich protein - Schizosaccharomyces pombe
An09g03130	Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O.; Function: catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Induction: catA mRNA is barely detectable in growing mycelia, highly induced during sporulation, and present in isolated spores.; Phenotype: catA-disrupted mutants produced spores were sensitive to H2O2, as compared to wild-type spores.; Remark: catA has heme as a cofactor.; Remark: catA is the major spore catalase.; Title: strong similarity to catalase A catA -Aspergillus nidulans; See PMID 8598056
An09g03140	Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH.; Remark: adhB was identified as a major stress protein and is induced both by exposure to ethanol and by elevated temperature (45 degrees C).; Title: similarity to alcohol dehydrogenase II adhB -Zymomonas mobilis; See PMID 1917831; See PMID 2059047
An09g03150	Title: weak similarity to cell differentiating factor BUF-3 from patent JP02009388-A - Homo sapiens
An09g03160	Function: DRS2 encodes an aminophospholipid-transporting ATPase.; Function: DRS2 has a possible role in late Golgi function.; Golgi; Localization: DRS2 localizes to late Golgi membranes.; Similarity: DRS2 has similarity to membrane-spanning Ca2+ ATPases.; Similarity: DRS2 is a member of the cation transporting (E1-E2) P-type ATPase superfamily.; Title: strong similarity to ATPase Drs2 -Saccharomyces cerevisiae; See PMID 8247005; See PMID 10601336
An09g03170	Phenotype: disruption of TRI12 of F. sporotrichioides results in both reduced growth on complex media and reduced levels of trichothecene production.; Remark: growth of TRI12 mutants on trichothecene-containing media is inhibited, suggesting that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: the ORF encoded protein and TRI12 from F. sporotrichioides show similarities to members of the major facilitator superfamily (MFS) of transporters.; Title: strong similarity to trichothecene efflux pump TRI12 - Fusarium sporotrichioides; plasma membrane; See PMID 10485289
An09g03180	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g03200	Title: strong similarity to protein SEQ ID NO:4585 from patent EP1033405-A2 - Arabidopsis thaliana
An09g03210	Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: Heme.; Function: the P450rm-monooxygenase system in microsomes of R. minuta might function in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: the P450rm gene product from Rhodotorula minuta acts as a bifunctional enzyme with isobutene-forming and benzoate 4-hydroxylase activities.; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702
An09g03220	Title: weak similarity to hypothetical protein BAA90383.1 - Oryza sativa
An09g03230	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g03240	Catalytic activity: (R)-mevalonate + CoA + 2 NADP(+) <=> (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH .; Title: strong similarity to 3-hydroxy-3-methylglutaryl coenzyme A reductase HmgA -Sulfolobus solfataricus; See PMID 9171410
An09g03250	Function: the human SN2 transporter mediates Na(+)-coupled transport of system N-specific amino acid substrates (glutamine, asparagine, and histidine). In addition, SN2 also transports serine, alanine, and glycine.; Remark: SN2 is an amino acid transport system N cloned from human a liver cell line.; Similarity: the ORF encoded protein shows also similarity to the Arabidopsis thaliana protein fragment SEQ ID NO: 51488 from patent EP1033405-A2, but its function is not decribed.; Title: similarity to amino acid transport system SN2 - Homo sapiens; plasma membrane; See PMID 11243884
An09g03260	Catalytic activity: Polygalacturonases random hydrolyse 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: the endo-polygalacturonase D pgaD is the only A. niger PG capable of hydrolyzing di-galacturonate.; Gene-ID: pgaD; Mapping: pgaD from A. niger is mapped to chromosome I; see EMBL Y18806.; Remark: pgaD = PGD.; See PMID 10675564
An09g03270	Remark: RTM1 overexpression in S. cerevisiae confers resistance to molasses. Its molecular function is unknown.; Title: strong similarity to hypothetical molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593
An09g03280	Remark: RTA1 overexpression in S. cerevisiae confers resistance to 7-aminocholesterol. Its molecular function is unknown.; Remark: alternate name for S. cerevisiae Rta1: YGR213C.; Title: strong similarity to hypothetical 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An09g03290	Function: the qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Pathway: in Neurospora crassa, five structural genes and two regulatory genes control the use of quinic acid as a carbon source.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580
An09g03300	Catalytic activity: the purified XylS enzyme from Sulfolobus solfataricus shows high hydrolytic activity on the disaccharide isoprimeverose and catalyzing the release of xylose from xyloglucan oligosaccharides.; Similarity: the xylS (Sulfolobus solfataricus) gene encodes a monomeric enzyme homologous to alpha-glucosidases, alpha-xylosidases, glucoamylases and sucrase-isomaltases of the glycosyl hydrolase family 31.; Title: strong similarity to alpha-xylosidase XylS -Sulfolobus solfataricus; See PMID 10801892
An09g03310	Title: strong similarity to hypothetical protein encoded by An02g05790 - Aspergillus niger
An09g03320	Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of he multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An09g03330	Title: similarity to hypothetical protein encoded by SCE66.10c - Streptomyces coelicolor
An09g03340	Remark: Botryotinia fuckeliana=Botrytis cinerea.; Similarity: the Bcmfs1 protein from Botryotinia fuckeliana belongs to the major facilitator family of transporters.; Title: strong similarity to MFS drug transporter Bcmfs1 - Botryotinia fuckeliana; plasma membrane; See PMID 11374155
An09g03350	Title: strong similarity to fumonisin permease SEQ ID NO:7 from patent WO200105980-A1 - Exophiala spinifera; plasma membrane
An09g03370	Title: weak similarity to hypothetical protein encoded by F16G20.170 - Arabidopsis thaliana
An09g03380	Similarity: the similarities of the ORF encoded protein to all matching proteins with lower scores are based on repetitive structures.; Title: similarity to hypothetical protein B24P7.110 - Neurospora crassa
An09g03390	Title: questionable ORF
An09g03420	Title: questionable ORF
An09g03430	Title: strong similarity to EST an_1400 -Aspergillus niger
An09g03440	Similarity: the ORF DNA sequence shows strong similarity to the EST an_3606 from Aspergillus niger.; Similarity: the similarity to CipA from Clostridium thermocellum is located in an highly repetetive sequence domain of CipA.; Title: similarity to S-layer protein CipA -Clostridium thermocellum; See PMID 8458832
An09g03450	Catalytic activity: D-ribulose 5-phosphate <=> D-xylulose 5-phosphate.; Phenotype: rpe1 null mutants are viable but show no ribulose-5-phosphate epimerase activity, cannot grow on D-xylulose, and are sensitive to hydrogren peroxide.; Remark: Rpe1 also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate.; Remark: synonyms for Rpe1 from S. cerevisiae are Epi1, Pos18 and YJL121c.; Title: strong similarity to ribulose-5-phosphate-epimerase Rpe1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8879247; See PMID 8929392
An09g03470	Similarity: the similarities of the ORF encoded protein to all matching proteins with lower scores are mainly based on repetitive structures.; Title: strong similarity to hypothetical verprolin related protein encoded by B24P7.40 - Neurospora crassa
An09g03480	Complex: S. cerevisiae Lsm subunits form a heteromer with a dougnut shape.; Function: S. cerevisiae Lsm2 binds specifically to the 3'-terminal U-tract of U6 snRNA.; Remark: synonyms for S. cerevisiae Lsm2 are Smx5,Snp3 and YBL026w.; Similarity: S. cerevisiae Lsm2 belongs to the snRNP SM proteins family.; Title: strong similarity to snRNA-associated sm-like protein Lsm2 - Saccharomyces cerevisiae; nucleus; See PMID 11333229; See PMID 10747033
An09g03490	Function: Mus musculus SNM1 is involved in DNA interstrand cross-links (ICLs) repair.; Remark: Mus musculus SNM1 is the mammalian homolog of the S. cerevisiae gene SNM1 (PSO2).; Title: strong similarity to protein involved in DNA repair SNM1 - Mus musculus; nucleus; See PMID 10848582
An09g03500	Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: iron; tetrahydropteridine.; Function: oxidoreductase acting on paired donors with incorporation of molecular oxygen with NADH or NADPH as one donor, and incorporation of one atom of oxygen; Gene-ID: bphA; Induction: bphA of A. niger is inducible by benzoate.; Mapping: bphA from A. niger is mapped to chromosome I; see list from DSM, EMBL X52521.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Phenotype: A. niger transformant with a multicopy bphA insert do not grow on benzoate, whereas a transformant with only one extra copy could grow.; Remark: bphA of A. niger is a member of a new P450 gene family designated P450LIII.; endoplasmatic reticulum; See PMID 1868576; See PMID 2250647
An09g03510	Function: Leu3p of S. cerevisiae is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: yeast zinc cluster proteins form a major class of yeast transcriptional regulators. they usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein. Leu3p of S. cerevisiae also recognizes CGG triplets, but when oriented in opposite direction, an everted repeat.; Similarity: Leu3p of S. cerevisiae belongs to the family of Zn(II)2Cys6 proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402
An09g03530	Title: strong similarity to hypothetical protein EAA62175.1 - Aspergillus nidulans
An09g03560	Similarity: the predicted A. niger protein is similar to several conserved microbial hypothetical proteins.; Title: similarity to hypothetical protein CC3092 -Caulobacter crescentus
An09g03570	Catalytic activity: citA of S. coelicolor catalyses the reaction citrate + CoA = acetyl-CoA + H(2)O + oxaloacetate.; Remark: a citA mutant of S. coelicolor was a glutamate auxotroph, indicating that citA encoded the major citrate synthase allowing flow of acetyl-CoA into the tricarboxylic acid (TCA) cycle. interruption of aerobic TCA cycle-based metabolism resulted in acidification of the medium and defects in morphological differentiation and antibiotic biosynthesis.; Similarity: the predicted A. niger protein is similar to several plant and microbial citrate synthases.; Title: similarity to citrate synthase citA -Streptomyces coelicolor; See PMID 11325948
An09g03580	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An09g03600	Function: AflR in A. flavus is required for the expression of the nor1 and ver1 genes.; Pathway: AflR in A. flavus is involved in the regulation of aflatoxin biosynthesis.; Similarity: AflR of A. flavus encodes a putative transcription factor containing a Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Similarity: the homology is limited to the N-terminus containing the Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Title: similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus; See PMID 8074521
An09g03620	Similarity: the predicted A. niger protein shows similarity to several conserved microbial hypothetical proteins.; Title: similarity to hypothetical protein aq_1250 -Aquifex aeolicus
An09g03630	Remark: Aut4p of S. cerevisiae is involved in autophagocytosis, a degradative transport pathway that delivers cytosolic proteins to the lysosome (vacuole). aut4-deleted cells show a partial reduction in total protein breakdown during nitrogen starvation.; Remark: a biologically active fusion protein of Aut4p and the green fluorescent protein is visualized at the vacuolar membrane and in punctate structures attached to the vacuole.; Similarity: the predicted A. niger protein is similar to Aut4p of S. cerevisiae which has limited homology to permeases.; Title: strong similarity to hypothetical protein Aut4 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11058089
An09g03640	Function: NPL1 of A. thaliana is a light-dependent autophosphorylating serine/threonine protein kinase that mediates the avoidance response of chloroplasts to high-intensity blue light.; Remark: A. thaliana NPL1, like A. thaliana NPH1,noncovalently binds the chromophore flavin mononucleotide (FMN) within two specialized PAS domains, termed LOV domains.; Similarity: the predicted A. niger protein is similar to plant blue light receptors (nonphototropic hypocotyl 1 (NPH1) and NPH-like 1 (NPL1)).; Title: similarity to non phototropic hypocotyl 1-like serine/threonine protein kinase NPL1 - Arabidopsis thaliana; See PMID 11251116; See PMID 11309623; See PMID 11371609
An09g03650	Title: weak similarity to hypothetical protein Ta0309 - Thermoplasma acidophilum
An09g03660	Function: translocation of neutral aliphatic and aromatic amino acids across the plasma membrane of the ascomycete Neurospora crassa requires a functional gene product of the mtr locus.; Remark: the N. crassa mtr gene product is covered by patent WO9521263-A1 (AC# AAR79909).; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 2843424; See PMID 8001794; See PMID 1838345
An09g03700	Title: similarity to hypothetical protein C09F12.2 -Caenorhabditis elegans
An09g03710	Similarity: weak similarity to C2H2 zinc finger protein Zas1A S. pombe.; Title: weak similarity to hypothetical protein encoded by An14g01970 - Aspergillus niger
An09g03720	Title: similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens
An09g03730	Induction: the E. coli aidB dehydrogenase is induced by alkylating agents.; Similarity: the E. coli aidB dehydrogenase belongs to the acyl-CoA dehydrogenase family.; Title: strong similarity to acyl CoA dehydrogenase aidB - Escherichia coli; See PMID 7713936
An09g03740	Similarity: weak similarities to phosphoesterases (EC 3. 1. -. -).; Title: strong similarity to hypothetical protein 239AB - Homo sapiens
An09g03750	Similarity: similarities correspond to multiple serine and threonine repeats.; Title: weak similarity to hypothetical fibroin 3 -Plectreurys tristis
An09g03760	Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Function: the lip I lipase of G. candidum hydrolyzes triacylglycerols into fatty acids and glycerol.; Remark: different G. candidum strains produce different isoforms of extracellular lipases I + II,diverging in substrate specifity.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; See PMID 2341377; See PMID 7578238; See PMID 8306978; See PMID 8370674
An09g03780	Catalytic activity: hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1; hydrolyses peptide amides.; Gene-ID: pepD; Mapping: pepD from A. niger is mapped to chromosome I (LG I); see list from DSM, PUBMED 9309173.; Remark: engineered A. niger mutants which are unable to produce functional PEPD can be used for increased recombinant production of heterologous proteins.; Remark: mutant subtilisin-type serine protease derived from Aspergillus niger - used to transform hosts to confer reduced protease activity, for improved yields in protein expression.; Remark: the reduced identity is due to the use of low complexity filter in the calculation of BLAST similarities.; vacuole
An09g03790	Remark: disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Remark: expression of FLU1 in C. albicans YKKB-13 mutants, lacking the ABC transporter gene PDR5, mediated resistance to fluconazole and also to cycloheximide.; Similarity: belongs to the multidrug efflux transporter family.; Similarity: no similarity in N-terminus.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8585712; See PMID 9124851; See PMID 11065353
An09g03800	Remark: other uses include peptide hydrolysis, waste treatment and cleavage of fusion proteins.; Remark: the B. subtilis hydrolase YQJL as well as other recombinant hydrolases from gram-positive bacteria are useful in cleaning (e. g. detergent) or textile treatment compositions, and in animal feeds.; Title: strong similarity to hydrolase protein YQJL from patent WO9927081-A2 - Bacillus subtilis
An09g03810	Remark: disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Remark: expression of FLU1 in C. albicans YKKB-13 mutants, lacking the ABC transporter gene PDR5, mediated resistance to fluconazole and also to cycloheximide.; Similarity: belongs to the multidrug efflux transporter family.; Similarity: no similarity to N-terminus of C. albicans FLU1.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8585712; See PMID 9124851; See PMID 11065353
An09g03820	Remark: mutational evidence suggests that the tamA gene has a positive role together with areA in regulating the expression of genes subject to nitrogen metabolite repression.; Remark: the A. nidulans tamA sequence shares significant homology with the UGA35/DAL81/DURL gene of S. cerevisiae.; Similarity: contains Zn-cluster domain generally involved in DNA-binding.; Title: strong similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; See PMID 8655534; See PMID 10079333; See PMID 10471703
An09g03830	Catalytic activity: 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO(2) + L-alanine.; Cofactor: pyridoxal phosphate.; Complex: homotetramer.; Remark: the dialkylglycine decarboxylase catalyzes both decarboxylation and amino transfer.; Similarity: belongs to the class-III of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to 2,2-dialkylglycine decarboxylase structural protein dgdA - Pseudomonas cepacia; cytoplasm
An09g03840	Title: strong similarity to hypothetical 65.9 kd protein SPAC31A2.12 - Schizosaccharomyces pombe
An09g03850	Similarity: similarity corresponds only to a central region of ORF2706 from H. sapiens; Title: similarity to ORFX ORF2706 polypeptide from patent WO200058473-A2 - Homo sapiens
An09g03860	Title: similarity to calcium binding protein P22 -Gallus gallus; centrosome; See PMID 7769011
An09g03870	Catalytic activity: Citrate = cis-aconitate + H(2)O,also converts isocitrate into cis-aconitate.; Complex: monomer.; Function: required for growth on non-fermentable carbon sources and for biosynthesis of glutamate.; Localization: mitochondrial and extramitochondrial.; Pathway: tricarboxylic acid cycle.; Remark: Aconitase has an active (4Fe-4S) and an inactive (3Fe-4S) forms.; Remark: the active (4Fe-4S) cluster is part of the catalytic site that interconverts citrate, cis-aconitase and iso-citrate.; Similarity: belongs to the aconitase/IPM isomerase family.; Title: strong similarity to mitochondrial aconitase hydroxylase Aco1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1972545
An09g03880	Similarity: similarities correspond to multiple threonine and proline residues.; Title: weak similarity to hypothetical polythreonine protein AAB61262.1 - Cryptosporidium parvum
An09g03890	Similarity: no similarity in N-terminus.; Title: strong similarity to hydroxic acid dehydrogenase-like protein from patent DE19912706-A1 -Staphylococcus aureus
An09g03900	Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH, also acts on D-glucitol (giving D-fructose) and other closely related sugar alcohols.; Cofactor: Zn2+.; Complex: homotetramer.; Function: also catalyzes the oxidation by NAD+ of sorbitol to fructose.; Similarity: belongs to the Zinc-containing alcohole-dehydrogenase-family.; Title: strong similarity to L-iditol-2 dehydrogenase SORD - Homo sapiens
An09g03910	Similarity: weak similarity to C-terminus of cotransporter protein SNST1 patent US5410031-A -Oryctolagus cuniculus.
An09g03920	Function: hydration and nonoxidative cleavage of feruloyl-SCoA to vanillin and acetyl-SCoA.; Title: strong similarity to p-hydroxycinnamoyl CoA hydratase/lyase vdh - Pseudomonas fluorescens; See PMID 9461612; See PMID 10543794
An09g03930	Function: the product of the pathogenicity gene Pth11p protein of M. grisea required for initiation of infection structure formation; Remark: the Pth11p protein of M. grisea can activate appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g03940	Function: the homologous gene Ilv-2 of N. crassa encodes alpha-keto-beta-hydroxylacyl reductoisomerase,required for the synthesis of isoleucine and valine.; Title: strong similarity to ketol-acid reductoisomerase ilv-2 - Neurospora crassa
An09g03950	Catalytic activity: ATP + L-Tryptophan + tRNA(Trp) = AMP + Pyrophosphate + L-Tryptophanyl-tRNA(Trp).; Title: strong similarity to cytosolic tryptophan--tRNA ligase Wrs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9046085
An09g03960	Function: catalyzes L-serine to D-serine racemization.; Title: strong similarity to serine racemase - Mus musculus
An09g03970	Remark: M. musculus XRCC2 protein is a highly conserved novel member of the recA/RAD51 recombination repair gene family, involved in high fidelity repair processes in mammals.; Similarity: similarity is restricted to the central region of M. musculus XRCC2 protein.; Title: similarity to recA/RAD51 family protein XRCC2 - Mus musculus; See PMID 9512535; See PMID 9628903
An09g03980	Function: the prodos protein of D. melanogaster is a transcriptional coactivator that associates with a member of the general transcription factor TFIID.; Title: similarity to prodos protein prod -Drosophila melanogaster; See PMID 11134347
An09g03990	Catalytic activity: 4 ferrocytochrome c + O(2) = 4 ferricytochrome c + 2 H(2)O.; Function: the small integral protein COX9 plays a role in holoenzyme assembly or stability of cytochrome c oxidase (respirarory chain complex).; Localization: mitochondrial inner membrane.; Title: similarity to subunit VIIa of cytochrome c oxidase Cox9 - Saccharomyces cerevisiae; localisation:mitochondrion
An09g04000	Catalytic activity: hUbc12 of H sapiens catalyses ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Function: ubiquitin-conjugating enzymes (UBC or E2 enzymes) catalyze the covalent attachment of ubiquitin to target proteins.; Similarity: additionally, the ORF shows similarity to human NCE-1 protein of patent WO9932624-A1.; Title: strong similarity to ubiquitin conjugating enzyme hUbc12 - Homo sapiens
An09g04010	Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: aminosugars metabolism.; Phenotype: disruption of chsC in A. fumigatus leads to no phenotype, however, disruption of of chsC together with chsG (another class III chitin synthase) leads to reduced colony radial growth rate and chitin synthase activity, the fungi conidiate poorly and produce highly branched hyphae.; Remark: chsC of A. fumigatus is a class III chitin synthase.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus; See PMID 8736545; See PMID 10731706
An09g04020	Remark: the ORF has an unusual exon/intron structure for A. niger.
An09g04030	Title: weak similarity to hypothetical protein encoded by An01g10470 - Aspergillus niger
An09g04050	Title: strong similarity to hypothetical OPY2 like protein CAD21287.1 - Neurospora crassa
An09g04060	Similarity: the predicted A. niger protein shows similarity to several hypothetical Zn(2)-Cys(6) zinc-finger proteins.; Title: strong similarity to hypothetical conserved protein 17E5.150 - Neurospora crassa
An09g04070	Catalytic activity: 2, 5-diketo-D-gluconate reductase of E. coli catalyses the reduction of 2,5-diketo-D-gluconate to 2-keto-L-gulonate.; Remark: 2,5-diketo-D-gluconate reductase of E. coli is active with NADPH as a preferred electron donor.; Similarity: the predicted A. niger protein shows strong similarity to 2,5-diketo-D-gluconate reductase (yqhE) from E. coli and many other oxidoreductases.; Title: strong similarity to 2,5-diketo-D-gluconate reductase yqhE - Escherichia coli; See PMID 10427017
An09g04080	Catalytic activity: gamma-glutamylcysteine synthetase of R. norvegicus catalyses the reaction ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine.; Complex: functional gamma-glutamylcysteine synthetase of R. norvegicus consists of one light subunit and one heavy subunit.; Pathway: gamma-glutamylcysteine synthetase catalyses the first step of glutathione (GSH) synthesis. the enzyme is also involved in glutamate metabolism.; Remark: gamma-glutamylcysteine synthetase can use L-aminohexanoate in place of glutamate.; Similarity: the predicted A. niger protein shows strong similarity to gamma-glutamylcysteine synthetase light chain from R. norvegicus and from other species.; Title: strong similarity to gamma-glutamylcysteine synthase light chain - Rattus norvegicus; See PMID 8104188
An09g04090	Similarity: best blastp matches in the patent database are protein kinases.; Title: strong similarity to hypothetical protein mNori-2 - Mus musculus
An09g04100	Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.; Remark: RPO31 of S. cerevisiae is also known as RPC1, RPC160 and YOR116C.; Title: strong similarity to 160 kD subunit of DNA-directed RNA polymerase III Rpo31 - Saccharomyces cerevisiae; nucleus; See PMID 3021184; See PMID 3896517
An09g04110	Remark: LepA of E. coli is a membrane-bound GTP-binding protein.; Remark: the sequence of yeast Guf1p is almost identical with the sequence given in patent # US5674996-A (yeast checkpoint control protein MEC3, acc. # AAW26665) . the sequence in this patent is different from the sequence of public S. cerevisiae MEC3.; Remark: yeast GUF1 (GTPase of Unknown Function) is located in a region of chromosome IV adjacent to the checkpoint gene MEC3.; Similarity: the predicted A. niger protein shows strong similarity to lepA from E. coli, which belongs to the family of elongation factor-type GTP-binding proteins. these proteins are highly conserved in procaryotes and eucaryotes.; Title: strong similarity to GTP-binding protein lepA - Escherichia coli; See PMID 2999765
An09g04120	Function: feedback control that prevents cells with incompletely assembled spindles from leaving mitosis; Title: strong similarity to spindle checkpoint protein Mad2 - Saccharomyces cerevisiae; See PMID 1651172
An09g04130	Title: strong similarity to hypothetical protein 12F11.190 - Neurospora crassa
An09g04140	Title: similarity to hypothetical protein encoded by gene 51 - Murid herpesvirus 4
An09g04150	Title: strong similarity to hypothetical transcriptional activator ptaA - Aspergillus nidulans; See PMID 11309119
An09g04170	Complex: SLY1 of S. cerevisiae binds to Sed5.; Function: SLY1 of S. cerevisiae is essential and has a role in vesicular trafficking from the endoplasmic reticulum to the Golgi apparatus.; Remark: SLY1 of S. cerevisiae is also known as YDR189W.; Similarity: belongs to the STXBP/UNC-18/SEC1 family.; Title: strong similarity to protein Sly1 -Saccharomyces cerevisiae; See PMID 9271199; See PMID 11481671; See PMID 1990290
An09g04180	Function: STE2 of S. cerevisiae has a role in transmitting mating pheromone to the G protein thereby activating it, which leads to growth arrest in G1 and the subsequent induction of mating genes.; Localization: STE2 of S. cerevisiae is an integral membrane protein.; Phenotype: a N388S mutation in STE2 of S. cerevisiae leads to a reduction in growth arrest after phermone treatment and impaired mating competence.; Remark: STE2 of S. cerevisiae is also known as YFL026W.; Similarity: belongs to family 4 of G-protein coupled receptors; Title: similarity to pheromone alpha-factor receptor Ste2 - Saccharomyces cerevisiae; See PMID 2839507; See PMID 3001640; See PMID 1128714
An09g04190	Title: weak similarity to tumor susceptibility protein tsg101 - Mus musculus
An09g04210	Title: weak similarity to hypothetical protein encoded by An15g01210 - Aspergillus niger
An09g04230	Remark: the encoded protein shows similarities to protein kinases from other organisms.; Title: similarity to protein kinase STY - Mus musculus; See PMID 7665564; See PMID 8617202; See PMID 1825055; See PMID 1986248
An09g04240	Title: similarity to hypothetical protein CAD37005.1 - Neurospora crassa
An09g04250	Catalytic activity: murine indoleamine 2,3-dioxygenase catalyses the reaction L-tryptophan + O2 = N-formylkynurenine.; Cofactor: murine indoleamine 2,3-dioxygenase requires heme as a cofactor.; Pathway: murine indoleamine 2,3-dioxygenase is involved in tryptophan catabolism.; Remark: indoleamine 2,3-dioxygenase acts on many substituted and unsubstituted indoleamines, including melatonin.; Similarity: the predicted A. niger protein shows strong similarity to murine indoleamine 2,3-dioxygenase,orthologues in other vertebrate species, the hypothetical yeast protein YJR078w and heme binding invertebrate myoglobins.; Title: strong similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus
An09g04280	Function: involved in tRNA-processing; Similarity: belongs to class-V of pyridoxal-phosphate-dependent aminotransferases; Similarity: strong, to nifs from nitrogen fixing bacteria; Title: strong similarity to tRNA splicing protein SPL1 - Candida maltosa; See PMID 8444805; See PMID 9544248
An09g04300	Function: RVS167 from S. cerevisiae is involved in cortical actin cytoskeleton organization.; Similarity: the predicted A. niger protein shows strong similarity to RVS167 from S. cerevisiae, which is a homologue of higher eukaryotes' amphiphysins. the yeast RVS167 gene product displays significant homology with the yeast Rvs161 protein and contains a SH3 domain at the C-terminal end.; Title: strong similarity to protein involved in actin distribution and bipolar budding Rsv167 -Saccharomyces cerevisiae; cytoskeleton; See PMID 8336735; See PMID 10393809; See PMID 10992286
An09g04330	Title: weak similarity to pro-phenol oxidase subunit 1 proPO-p1 - Anopheles gambiae
An09g04335	Remark: the ORF is truncated due to a transposon insertion.
An09g04350	Remark: the ORF encoded protein probably does not belong to the genome of A. niger, it is identical with the transposase of insertion sequence IS10 from Escherichia coli. This sequence could be inserted during subcloning or sequencing of the A. niger DNA.; Title: strong similarity to transposase of insertion sequence IS10 - Escherichia coli [putative cloning actefact]; See PMID 8132525
An09g04360	Title: weak similarity to hypothetical protein SPy1903 - Streptococcus pyogenes
An09g04370	Similarity: the N-terminal third of the predicted protein has no similarity to Rv0276 of M. tuberculosis.; Title: similarity to hypothetical protein Rv0276 -Mycobacterium tuberculosis
An09g04380	Title: weak similarity to hypothetical protein yqjA - Bacillus subtilis
An09g04390	Catalytic activity: salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2.; Cofactor: salicylate hydroxylase of P. putida is a flavoprotein (FAD).; Function: salicylate hydroxylase of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Induction: salicylate hydroxylase of P. putida isinduced by salicylate.; Pathway: salicylate hydroxylase of P. putida is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Title: strong similarity to salicylate hydroxylase sal - Pseudomonas putida; See PMID 7629025; See PMID 8695632
An09g04410	Similarity: the N-terminal part of the predicted protein shows weak similarity to Neutrophil chemotactic factor 2-beta preform, patent JP08020600-A, of R. norvegicus, but the proteins have very different length.
An09g04420	Title: questionable ORF
An09g04440	Title: strong similarity to hypothetical protein CAD70771.1 - Neurospora crassa
An09g04450	Similarity: several BLASTP matches are due to the C-terminal low complexity region, especially to the poly-glycine stretch, and cannot be considered significant.
An09g04470	Title: strong similarity to hypothetical protein YOR197w - Saccharomyces cerevisiae
An09g04480	Title: questionable ORF
An09g04490	Title: questionable ORF
An09g04510	Similarity: a poly-alanine stretch in the N-terminal part of the predicted ORF produces some additional non-significant BLASTP matches.; Similarity: the weak similarity to GP protein of the Marburg virus involves only the N-terminal fifth of the predicted protein.; Title: weak similarity to protein GP - Marburg virus; See PMID 8495737
An09g04520	Title: strong similarity to hypothetical membrane protein YLR285w - Saccharomyces cerevisiae
An09g04530	Function: KTI12 of S. cerevisiae is involved in resistance to K. lactis killer toxin, that causes cells to arrest in G1 phase.; Title: strong similarity to protein Kti12 -Saccharomyces cerevisiae; See PMID 8065362; See PMID 11296232
An09g04540	Remark: N-terminally truncated ORF due to contig border.; Similarity: the similarities are mainly based on the zinc finger motifs.; Title: strong similarity to hypothetical protein EAA63983.1 - Aspergillus nidulans [truncated ORF]
An09g04550	Remark: C-terminally truncated ORF due to contig border.; Title: weak similarity to protein phosphatase type 1 Gac1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1310938; See PMID 1651919
An09g04570	Similarity: very weak, local similarity to E. coli TraD, a cell-envelope protein with unknown function.
An09g04580	Catalytic activity: palmitoyl-protein thioesterase of R. norvegicus catalyzes the reaction: palmitoyl-protein + H2O = palmitate + protein.; Catalytic activity: palmitoyl-protein thioesterase of R. norvegicus is specific for long-chain thioesters of fatty acids; hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.; Phenotype: a protein showing very strong similarity to palmitoyl-protein thioesterase of R. norvegicus was isolated in humans as the gene mutated in infantile neuronal ceroid lipofuscinosis, a severe neurodegenerative disorder, characterized by the accumulation of proteolipid storage material in brain and other tissues, suggesting that the disease is a consequence of abnormal catabolism of acylated proteins.; Title: strong similarity to palmitoyl-protein thioesterase - Rattus norvegicus; See PMID 7901201; See PMID 7916016; See PMID 8786130
An09g04590	Similarity: the predicted ORF, in the same region,shows similarity to another protein patented under patentnumber EP0999284.; Similarity: the similarity to CaMR212 of C. albicans is limited to the C-terminal half of the predicted ORF.; Title: similarity to CaMR212 from patent WO200015838-A2 - Candida albicans
An09g04600	Function: the human pancreatic cancer antigens have cytostatic, neuroprotective, nootropic, immunomodulatory,relaxant, contraceptive, gynaecological, cardiant and antiinflammatory activities, and can be used in gene therapy.; Title: similarity to pancreatic cancer antigen protein sequence SEQ ID NO:464 from patent WO200055320-A1 -Homo sapiens
An09g04620	Title: strong similarity to hypothetical protein YDR348c - Saccharomyces cerevisiae
An09g04630	Title: questionable ORF
An09g04640	Complex: nimQ/MCM2 is part of the DNA replication licensing complex, that binds chromatin in G1-phase and leaves chromatin when cells enter and progress through S-phase.; Function: the binding to the chromatin of the licensing factor or factors causes the chromatin to become competent for DNA replication, but once initiation of DNA replication has occurred, the licensing factor would be destroyed, thereby preventing re-replication of the DNA.; Localization: in S. cerevisiae most of MCM2 is distributed throughout the cell cycle to both cytoplasm and nucleoplasm at relatively constant levels.; Similarity: nimQ of A. nidulans is the functional homologue of MCM2 of S. cerevisiae.; Title: strong similarity to hypothetical DNA replication licensing factor nimQ - Aspergillus nidulans; See PMID 8882583; See PMID 9407133; See PMID 7701565; See PMID 8542275; See PMID 8720069
An09g04650	Title: similarity to hypothetical protein mlo2p -Schizosaccharomyces pombe
An09g04660	Function: UME5/SRB10 and UME3/SRB11 form a kinase-cyclin pair in the RNA polymerase II holoenzyme, and are essential for a normal transcriptional response to galactose induction in vivo, and are involved in CTD (carboxy-terminal domain) phosphorylation and this modification has a role in the response to transcriptional regulators in vivo.; Remark: SSN3, SRB10 and YPL042C are alternative names for UME5.; Remark: the ORF encoded protein also shows similarity to other cyclin dependend kinases.; Similarity: UME5 belongs to the ser/thr family of protein kinases. cdc2/cdkx subfamily.; Title: strong similarity to meiotic mRNA stability protein kinase Ume5 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 7877695; See PMID 8164691
An09g04680	Function: rat GLUT2 is sufficient to rescue E. coli mutant defective in glucose uptake.; Localization: immunofluorescence analysis showed that rat GLUT2 is present in the plasma membrane of the insulin-producing beta cells.; Title: similarity to hepatic glucose transport protein GLUT2 - Rattus norvegicus; plasma membrane; See PMID 3048704
An09g04690	Title: strong similarity to hypothetical protein EAA74627.1 - Gibberella zeae
An09g04700	Title: weak similarity to hypothetical protein KLF12 - Homo sapiens
An09g04710	Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Remark: YGR170w is the systematic name for PSD2 of S. cerevisiae.; Title: strong similarity to phosphatidylserine decarboxylase 2 Psd2 - Saccharomyces cerevisiae; See PMID 10793889; See PMID 7890740
An09g04730	Title: similarity to hypothetical protein 12F11.250 - Neurospora crassa
An09g04780	Title: similarity to hypothetical integral membrane protein - Schizosaccharomyces pombe
An09g04790	Remark: blastp with the predicted A. niger protein only retrieves putative random hits to proline and glutamine rich proteins.; Title: weak similarity to enabled ena - Drosophila melanogaster
An09g04810	Function: K. lactis HGT1 is a high affinity glucose transporter.; Remark: expression of HGT1 from K. lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: K. lactis HGT1 belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An09g04820	Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus
An09g04830	Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and pth11 of M. grisea, which is 200 aa longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g04840	Function: S. cerevisiae TOK1 mediates outwardly-rectifying potassium currents activated by depolarization.; Regulation: Activation of S. cerevisiae Tok1 channels under steady-state conditions is dependent upon ATP in the cytoplasmic solution.; Remark: alternative names for S. cerevisiae TOK1 are YPK1, YORK and DUK1.; Title: strong similarity to outwardly-rectifying potassium channel Tok1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8723646; See PMID 9516239
An09g04850	Function: C. testosteroni TsaC is involved in aromatic compound catabolism.; Similarity: C. testosteroni TsaC belongs to the short-chain, zinc-independent dehydrogenases.; Title: strong similarity to p-sulfobenzyl alcohol dehydrogenase TsaC - Comamonas testosteroni; See PMID 9006050
An09g04860	Remark: although the predicted A. niger protein shows similarity to several hypothetical and validated transcription factors no DNA-binding motif was predicted.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360
An09g04870	Title: weak similarity to polypeptide SEQ ID NO:6186 from patent WO200153312-A1 - Homo sapiens
An09g04890	Complex: binding studies and coimmunoprecipitation established that human SNAP-23 binds to syntaxin 6 in vitro and in vivo.; Function: during specific granule secretion in neutrophiles human syntaxin 6 interacts with SNAP-23.; Function: in human neutrophiles syntaxin 6 is involved in exocytosis and acts as a target for secretion of specific and azurophilic granules.; Localization: human syntaxin 6 was reported to localize mainly in the plasma membrane of neutrophiles while in other cell types it localises to the trans-Golgi.; Remark: while References PubMed ID 8663448 and 9243506 describe syntaxin 6 as Golgi specific syntaxin involved in trans-Golgi network vesicle trafficking Referecence 11001914 describes it as plasma membrane associated syntaxin involved in exocytosis of neutrophiles.; Title: similarity to syntaxin 6 - Homo sapiens; See PMID 9243506; See PMID 11001914; See PMID 8663448
An09g04900	Complex: human SET binds to an HLA class II affinity matrix.; Complex: human SET forms a tripartite complex with PP2A and HRX.; Function: fusion of human SET to CAN (a nuclear pore complex subunit) is common in some forms of leukemia.; Function: human SET is a potent and specific inhibitor of PP2A.; Function: human SET is implicated in tumour relevant signalling events controlling mitosis and/or recognition of tumorous cells.; Title: similarity to inhibitor of PP2A SET - Homo sapiens; nucleus; See PMID 11231286
An09g04910	Function: A. nidulans NmrA interacts with the DNA-binding domain and the extreme C terminus of AreA, an activator of nitrogen metabolite gene expression, to inhibit DNA binding under nitrogen sufficient conditions.; Function: A. nidulans NmrA is an inhibitor of the induction of nitrogen metabolite genes.; Title: strong similarity to mediator of nitrogen metabolite repression nmrA - Aspergillus nidulans; See PMID 9106362; See PMID 9537404; See PMID 10471703
An09g04940	Title: strong similarity to transposase of Tan1 -Aspergillus niger; See PMID 9003286
An09g04950	Catalytic activity: lysophospholipases 2-lysophosphatidylcholine + H(2)O to glycerophosphocholine + a fatty acid anion.; Complex: rat lysophospholipase-transacylase exists as a monomer.; Function: rat lysophospholipase-transacylase catalyzes not only the hydrolysis of 1-acyl-sn-glycero-3-phosphocholine, but also the transfer of its acyl chain to a second molecule of 1-acyl-sn-glycero-3-phosphocholine to form phosphatidylcholine.; Function: rat lysophospholipase-transacylase is involved in fatty acid remodeling of phospholipids.; Remark: rat lysophospholipase-transacylase is selective for choline lysophospholipid, ethanolamine,inositol, and serine lysophospholipids were not good substrates.; Repression: for rat lysophospholipase-transacylase phosphatidic acid was a potent competitive inhibitor, less potent were lysophosphatidic acid, palmitoyl-L-carnitine,and fatty acid.; Title: strong similarity to lysophospholipase-transacylase - Rattus norvegicus; See PMID 9276665; See PMID 9575212; See PMID 10320809; See PMID 8119970
An09g04960	Complex: cdc2 forms a complex with cyclin B.; Function: cdc2 kinase governs M phase, controls the onset of S phase and, in addition, ensures that there is only one S-phase per cell cycle.; Localization: nuclear translocation of the cyclinB/cdc2 complex is executed specifically at the onset of M-phase.; Title: similarity to cyclin dependent kinase cdc2 -Zea mays; deleted EC_number 2.7.1.37; See PMID 8855663; See PMID 9552419; See PMID 11063929; See PMID 2014258
An09g04970	Function: Bcl-3, p50, and Pirin are sequestered into quarternary complexes on NF-kappaB DNA binding sites,thereby modulating NF-kappaB driven gene expression.; Function: human Pirin likely acts as cofactor of transcriptional regulators.; Function: human Pirin was isolated by a yeast two-hybrid screen as an interactor of nuclear factor I/CCAAT box transcription factor (NFI/CTF1).; Function: using the yeast two-hybrid-system Pirin was identified as Bcl-3 interacting protein.; Localization: confocal immunofluorescence experiments demonstrate a predominant localization of human Pirin within dot-like subnuclear structures.; Title: similarity to transcription cofactor Pirin -Homo sapiens; nucleus; See PMID 9079676; See PMID 10362352
An09g04980	Title: weak similarity to zinc binuclear cluster protein sequence #33 from patent WO200224865-A2 -Unclassified organism; nucleus
An09g04990	Catalytic activity: acetamidases catalyze the conversion of a Monocarboxylic acid amide + H(2)O to a Monocarboxylate + NH3.; Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 9044292; See PMID 3036667; See PMID 7847883
An09g05000	Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of human IPP, which is equivalent to the BTB/POZ/kelch domain.; Title: weak similarity to actin-binding protein IPP - Homo sapiens; See PMID 10072760
An09g05010	Function: S. cerevisiae HNM1 mediates the import of choline, ethanolamine, nitrogen mustard and nitrogen half mustard.; Regulation: expression of S. cerevisiae HNM1 in wild-type cells is only regulated by the phospholipid precursors inositol and choline via the phospholipid regulatory genes INO2, INO4, and OPI1.; Remark: an alternative name for S. cerevisiae HNM1 is CTR.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793; See PMID 8264542
An09g05040	Title: similarity to hypothetical protein B1D4.110 -Neurospora crassa
An09g05050	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An09g05060	Function: Rdr1 from S. cerevisiae is a transcriptional repressor of five genes (including Pdr5 an efflux pump that confers multidrug resistance).; Function: deletion of RDR1 in S. cerevisiae results in an increased resistance to cycloheximide.; Title: strong similarity to transcription repressor Rdr1 - Saccharomyces cerevisiae; See PMID 11882665
An09g05070	Function: expression of C. albicans Flu1 mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: FLU1 of C. albicans is a member of the major falicitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An09g05080	Catalytic activity: tyrosine/phenylalanine aminotransferases convert L-tyrosine/L-phenylalanine + 2-oxoglutarate to 4-hydroxyphenylpyruvate + L-glutamate.; Function: S. cerevisiae ARO8 is active not only with the aromatic amino acids, but also with methionine,alpha-aminoadipate, and leucine when phenylpyruvate is the amino acceptor, and in the reverse reactions with their oxo-acid analogues and phenylalanine as the amino donor.; Function: S. cerevisiae ARO8 is specialised for aromatic amino acid and alpha-aminoadipate transamination.; Function: S. cerevisiae ARO8 may be able to play a role in several otherwise unrelated metabolic pathways.; Function: S. cerevisiae aro8 and aro9 (aromatic aminotransferase I+II) double mutants are auxotrophic for both phenylalanine and tyrosine, while neither of the single mutants displays any nutritional requirement.; Regulation: S. cerevisiae ARO8 expression is subject to the general control of amino acid biosynthesis.; Remark: the systematic name for S. cerevisiae ARO8 is YGL202w.; Similarity: S. cerevisiae ARO8 is a member of the aminotransferase subgroup I.; Title: similarity to aromatic aminotransferase I Aro8 - Saccharomyces cerevisiae; See PMID 9491083; See PMID 9491082
An09g05100	Title: similarity to Impact - Mus musculus; See PMID 11116084
An09g05110	Function: M. aeruginosa McyG is involved in synthesis of the peptide-polyketide microcystin.; Title: strong similarity to peptide-polyketide synthase McyG - Microcystis aeruginosa; See PMID 11033079
An09g05120	Catalytic activity: triacylglycerol lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Title: similarity to lipase lip1 - Geotrichum candidum; See PMID 8370674
An09g05130	Catalytic activity: monophenol monooxygenases convert L-tyrosine + L-DOPA + O(2) to L-DOPA + DOPAquinone + H(2)O.; Complex: S. antibioticus MelC1 protein is involved in the transfer of copper ion to apotyrosinase MelC2 via binary complex formation.; Function: S. antibioticus tyrosinase melC2 is responsible for melanin synthesis.; Localization: most of the tyrosinase activity was secreted during growth of S. antibioticus.; Regulation: S. antibioticus MelC1 is required for activation and secretion of MelC2.; Title: similarity to monophenol monooxygenase melC2 - Streptomyces antibioticus; extracellular/secretion proteins; See PMID 1400329; See PMID 3932128
An09g05140	Similarity: the predicted A. niger protein shows weak similarity to several dehydrogenases and contains dehydrogenase motifs.; Title: strong similarity to hypothetical protein cipA - Aspergillus nidulans
An09g05150	Title: similarity to protein fragment SEQ ID NO:3767 from patent EP1108790-A2 - Corynebacterium glutamicum
An09g05160	Function: S. cerevisiae SCS3 is involved in phospholipid metabolism.; Function: S. cerevisiae SCS3 is involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis.; Title: weak similarity to protein required for inositol prototrophy Scs3 - Saccharomyces cerevisiae; See PMID 7706223
An09g05170	Title: similarity to hypothetical protein 15E11.110 - Neurospora crassa
An09g05180	Remark: L4 of S. cerevisiae is also called L2A, RP2,RPL4A, RPL2A, RPL2, YBR031W or YBR0315.; Remark: in S. cerevisiae, the genes coding for the ribosomal protein L4 are present in two copies per haploid genome.; Remark: the ORF is longer than L4 of S. cerevisiae (457 compared to 361 amino acids).; Remark: the amino acid sequence shows also strong similarity to many other L4 ribosomal proteins of different organisms.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L4 - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921; See PMID 3062369
An09g05200	Title: similarity to hypothetical transcription regulator SPAC18G6.01c - Schizosaccharomyces pombe
An09g05210	Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical protein encoded by ORF NT2RP3001426 - Homo sapiens [truncated ORF]
An09g05220	Function: putatively involved in heat shock response.; Remark: truncated ORF due to contig border.; Title: weak similarity to chaperone protein 6 (HCHP-6) from patent WO200017358-A2 - Homo sapiens [truncated ORF]
An09g05230	Function: Skip is highly homologous to the Drosophila melanogaster protein Bx42 which is found associated with chromatin in transcriptionally active puffs of salivary glands.; Remark: Skip from H. sapiens is also known as SNW1.; Title: strong similarity to nuclear protein Skip -Homo sapiens; nucleus; See PMID 9569025
An09g05240	Title: strong similarity to hypothetical protein CAE76169.1 - Neurospora crassa
An09g05250	Similarity: shows strong similarity to WD domain (G-beta repeat) resulting in variing similarities to proteins containing such domains.; Title: strong similarity to hypothetical protein MVP7.5 - Arabidopsis thaliana
An09g05260	Function: CDC12 of S. cerevisiae is involved in proper bud growth and cytokinesis.; Function: it is required for control of bud growth during mitosis.; Function: it is required for mitosis-specific activation of Gin4p.; Function: it is required for pheromone-induced morphogenesis.; Function: it is required for proper localization of Afr1p.; Title: strong similarity to cell division control protein Cdc12 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9201710; See PMID 9813092
An09g05270	Function: Pwp2p exists in a proteinaceous complex,possibly associated with the cytoskeleton, where it functions in control of cell growth and separation.; Function: it is required for bud-site selection and cell separation.; Localization: HA-Pwp2p of S. cerevisiae was clustered at multiple points in the cytoplasm, probably associates with the cytoskeleton.; Similarity: shows weaker similarity at the carboxyterminus.; Title: strong similarity to periodic tryptophan protein Pwp2 - Saccharomyces cerevisiae; cytoplasm
An09g05280	Similarity: the ORF encoded protein shows also weak similarity to putative polyketide cyclase snoaM from Streptomyces nogalater.; Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus
An09g05290	Function: exonuclease II (ExoII) from S. pombe is a 5'-->3' single-stranded DNA exonuclease.; Function: it is involved in DNA and/or RNA metabolism in vivo.; Similarity: ExoII is a homologue of the multifunctional S. cerevisiae Sep1 protein.; Title: strong similarity to exonuclease II SPAC17A5.14 - Schizosaccharomyces pombe; nucleus; See PMID 8188690; See PMID 8781170
An09g05300	Function: RbAp48 and RbAp46 may have shared as well as unique functions in the regulation of cell proliferation and differentiation.; Function: the retinoblastoma protein (Rb) interacts with multiple cellular proteins that mediate its cellular function.; Similarity: shows strong similarity to first 400 aa and almost no similarity at the carboxyterminus.; Title: strong similarity to G1/S transition control protein-binding protein RbAp48 - Mus musculus; See PMID 7503932
An09g05310	Function: catalyzes synthesis of D-erythro-7,8-dihydroneopterintriphosphate from GTP.; Pathway: tetrahydrofolate pathway, GTP cyclohydrolase I catalyses the first step in biosynthesis of tetrahydrofolate in prokaryotes and of tetrahydrobiopterin in vertebrates.; Similarity: GTP cyclohydrolase seem to be conserved among the species but less conserved at the aminoterminus.; Similarity: Nevertheless it is possible that the ORF is too long at the aminoterminus, perhapes alternative splicing exists (human).; Title: strong similarity to GTP cyclohydrolase I Fol2 - Saccharomyces cerevisiae; See PMID 10049741; See PMID 8573145
An09g05320	Title: similarity to hypothetical protein EAA59211.1 - Aspergillus nidulans
An09g05330	Title: similarity to hypothetical protein 4MeS -Metarhizium anisopliae
An09g05340	Remark: FUM5 is a PKS gene required for fumonisin biosynthesis.; Remark: biochemical analyses indicate that fumonisins are a product of either polyketide or fatty acid biosynthesis.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 10872449
An09g05350	Catalytic activity: Penicillin + H2O = a Carboxylate + 6-Aminopenicillanate.; Remark: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Remark: similar to patent US5516679-A.; Title: strong similarity to mature penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum
An09g05360	Catalytic activity: dCTP + H2O = dUTP + NH3.; Pathway: pyrimidine metabolism; Similarity: to many dCTP deaminases.; Title: similarity to hypothetical dCTP deaminase AF1108 - Archaeoglobus fulgidus
An09g05370	Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: kinases of the CDC2 family play a key role in cell cycle regulation and gene expression.; Remark: the human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase.; Title: strong similarity to protein kinase isoform 1 of CDC2L5 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 11125699; See PMID 11162436
An09g05380	Remark: Patent: WO9943820-A1.; Remark: the zea mays sequence represents a plant translation factor designated eIF-4E. eIF-4E is a translation factor which binds to a m^7G cap-binding protein. The eIF-4E nucleotide sequence may be used to control protein synthesis in plants.; Title: strong similarity to eIF-4E protein from patent WO9943820-A1 - Zea mays
An09g05390	Remark: questionable genestructure, large intron and only 36 aa protein predicted.; Title: questionable ORF
An09g05400	Remark: SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.; Remark: reproductive organs, such as testis, ovary,and prostate, contained much higher amounts of SUSP1 mRNA than colon and peripheral blood leukocyte, whereas other tissues, such as heart and spleen, had little or none.; Title: strong similarity to SUMO-1-specific protease SSP1 - Homo sapiens; See PMID 10799485
An09g05410	Remark: AIG1 and AIG2 (for avrRpt2-induced gene),exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2.; Remark: the induction patterns of the AIG genes and ELI3 demonstrate that different resistance gene-avr gene combinations can elicit distinct defense responses.; Title: similarity to avrRpt2-induced protein AIG2 -Arabidopsis thaliana; See PMID 8742710
An09g05420	Remark: alternative name for SPC3 is YLR066w.; Remark: it is shown that Spc3p is required for cell growth and signal peptidase activity within the yeast endoplasmic reticulum.; Similarity: to many eukaryotic signal peptidases.; Title: similarity to signal peptidase subunit Spc3 -Saccharomyces cerevisiae; See PMID 9148930; See PMID 8910564
An09g05430	Title: weak similarity to hypothetical mucin-like protein EMUCt-2 - Trypanosoma cruzi; See PMID 9556557
An09g05460	Catalytic activity: ATP + [pyruvate dehydrogenase (lipoamide)] = ADP + [pyruvate dehydrogenase (lipoamide)] phosphate.; Remark: pyruvate dehydrogenase kinase in Arabidopsis functions as negative regulator of the mitochondrial pyruvate dehydrogenase complex.; Title: strong similarity to pyruvate dehydrogenase (lipoamide) kinase PDK - Arabidopsis thaliana; localisation:mitochondrion; See PMID 10737148
An09g05470	Remark: questionable genestructure.
An09g05480	Catalytic activity: ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Complex: HAUSP of H. sapiens is a subset of ND10.; Function: HAUSP of H. sapiens is an ubiquitin-specific protease.; Remark: HAUSP of H. sapiens is also called USP7.; Remark: HAUSP of H. sapiens is strongly bound by Vmv110, a Herpes simplex virus type 1 immediate-early protein, which induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.; Remark: ND10 constitutes nuclear bodies.; Remark: ubiquitin-specific proteases (UBPs) are a family of unique hydrolases that specifically remove polypeptides covalently linked via peptide or isopeptide bonds to the C-terminal glycine of ubiquitin.; Title: strong similarity to ubiquitin specific protease HAUSP - Homo sapiens; See PMID 9428630; See PMID 9658103; See PMID 9847347; See PMID 9130697
An09g05490	Function: receptors for cargo proteins that are transported by COP I - (coat protein I) and/or COP II-coated vesicles between the endoplasmic reticulum and the Golgi complex in Polysphondylium pallidum.; Title: strong similarity to COP-coated vesicle membrane protein P24 homolog lbrA - Polysphondylium pallidum; See PMID 10571036
An09g05500	Remark: protein shows weak similarities to motifs of RNA-polymerase subunits.
An09g05510	Remark: blast hits include a repetitive sequence (poly G).; Remark: questionable genestructure because of a large intron.; Title: weak similarity to hypothetical protein Y51H1A.4 - Caenorhabditis elegans
An09g05520	Remark: the ORF is short in length.
An09g05540	Remark: the ORF shows strong and highly specific similarity to the N. crassa protein. Additionally, the ORF shows some unspecific similarity to other proteins due to it's proline-rich sequence.; Title: strong similarity to hypothetical protein encoded by gene B18D24.90 - Neurospora crassa
An09g05550	Similarity: the ORF shows unspecific similarity to some proteins due to it's serine-rich sequence.; Title: weak similarity to hypothetical protein EAA53565.1 - Magnaporthe grisea
An09g05570	Title: weak similarity to Recq helicase 5 RecQ5 -Drosophila melanogaster
An09g05580	Remark: lactate transport across cell membranes is mediated by a family of proton-coupled monocarboxylate transporters (MCTs).; Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 11005765
An09g05590	Remark: the zinc finger of the S. pombe protein is not part of the homologous region between the two proteins.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical transcriptional regulatory protein SPAC1F7. 11C from Schizosaccharomyces pombe.; Similarity: the ORF is about 100 amino acids shorter than the S. pombe protein and the homologie spans the central part of both proteins.; Title: weak similarity to zinc binuclear cluster protein sequence #108 from patent WO200224865-A2 -Unclassified organism
An09g05600	Title: similarity to hypothetical protein CAD11369.1 - Neurospora crassa
An09g05610	Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450
An09g05620	Title: weak similarity to hypothetical protein encoded by An04g05450 - Aspergillus niger
An09g05625	Title: similarity to EST SEQ ID NO:6052 from patent WO200056762-A2 - Aspergillus oryzae
An09g05630	Similarity: the ORF overlaps with the A. niger EST NO:4130.; Title: strong similarity to hypothetical protein encoded by gene B18D24.80 - Neurospora crassa
An09g05640	Alternative name: SSL2, LOM3, YIL143C.; Function: RAD25 is a DEAD/H box-containing helicase,which is required for promoter escape in vivo.; Function: S. cerevisiae RAD25 is required for nucleotide excision repair in RNA polymerase II transcription.; Title: strong similarity to subunit of transcription initation factor TFIIH DNA helicase Rad25 - Saccharomyces cerevisiae; nucleus; See PMID 10713451; See PMID 7891722
An09g05650	Similarity: the ORF is much longer than the N. crassa protein (956 compared to 354 amino acids).; Similarity: the ORF shows strong similarity to the complete sequence of the N. crassa protein.; Title: strong similarity to hypothetical protein encoded by gene B18D24.50 - Neurospora crassa
An09g05655	Title: strong similarity to SEQ ID NO:4184 from patent WO200056762-A2 - Aspergillus niger
An09g05660	Remark: the deletion of Qns1 in S. cerevisiae is lethal.; Title: strong similarity to NAD+ synthase Qns1 -Saccharomyces cerevisiae
An09g05670	Remark: yeast protein belongs to the nudix hydrolase family and is a conserved hypothetical protein in various species, i. e. S. pombe, D. radiodurans, P. aeruginosa etc.; Title: similarity to hypothetical protein YGL067w -Saccharomyces cerevisiae
An09g05680	Similarity: the ORF is aspartic and glutamic acid-rich and thus shows also unspecic similarity to other proteins.; Similarity: the ORF shows strong and specific N-terminal similarity to the N. crassa protein.; Title: strong similarity to hypothetical protein of gene 93G11.180 - Neurospora crassa
An09g05690	Alternative name: fmo1, fmo2, fmo3, fmo4, fmo5,tissuespecific nomenclature.; Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.; Remark: the human protein is involved in the oxidative metabolism of a variety of xenobiotics.; Title: similarity to dimethylaniline monooxygenase 4 (N-oxide forming) FMO4 - Homo sapiens; See PMID 9804831; See PMID 11042094; See PMID 1417778
An09g05700	Title: strong similarity to hypothetical conserved protein of gene 12F11.210 - Neurospora crassa
An09g05710	Remark: blast hits result from repetitive sequences and cover only part of the sequence.; Title: similarity to desmoplakin I DSP - Homo sapiens; See PMID 1689290
An09g05730	Remark: alb1 is required for conidial pigmentation in A. fumigatus and involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase alb1 - Aspergillus fumigatus; See PMID 9620950; See PMID 10515939
An09g05760	Remark: partial similarity.; Title: similarity to hypothetical protein SPAC9G1.06c - Schizosaccharomyces pombe
An09g05770	Catalytic activity: (polyphosphate)n + H2O = (polyphosphate)n-1 + orthophosphate.; Function: degradation of inorganic polyphosphates.; Remark: belongs to the PPase class C family.; Title: strong similarity to cytosolic exopolyphosphatase Ppx1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7860598
An09g05780	Catalytic activity: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanoate + NH(3).; Remark: 1-aminocyclopropane-1-carboxylic acid (ACC) is a precursor of the plant hormone ethylene.; Remark: protein is truncated due to the contig beginning.; Title: strong similarity to ACC deaminase -Penicillium citrinum [truncated ORF]; See PMID 10737185
An09g05790	Remark: homology is restricted to C-terminal BAG domains.; Title: weak similarity to BAG-family molecular chaperone regulator-4 - Homo sapiens
An09g05800	Function: protein acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis.; Title: strong similarity to transcription regulator rum1 - Ustilago maydis; nucleus; See PMID 11029697
An09g05830	Title: strong similarity to hypothetical protein 8D4.30 - Neurospora crassa
An09g05840	Catalytic activity: ATP + thymidine 5'-phosphate <=> ADP + thymidine 5'-diphosphate.; Title: strong similarity to thymidylate kinase CDC8 - Homo sapiens
An09g05850	Catalytic activity: tRNA guanine + queuine = tRNA queuine + guanine.; Remark: important for virulence in Shigella flexneri.; Remark: similarity only with the C-terminus of the proteins.; Title: similarity to queuine tRNA-ribosyltransferase - Shigella flexneri; See PMID 8045893
An09g05860	Catalytic activity: 5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH.; Title: strong similarity to methylenetetrahydrofolate reductase (NADPH) Met12 -Saccharomyces cerevisiae; See PMID 10600168
An09g05870	Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.; Title: strong similarity to nucleoside-diphosphate kinase NDK-1 - Neurospora crassa; cytoplasm; See PMID 10583364
An09g05880	Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Title: strong similarity to alpha-glucosidase ModA -Dictyostelium discoideum; See PMID 96112; See PMID 96113
An09g05890	Title: similarity to hypothetical membrane protein YMR010w - Saccharomyces cerevisiae
An09g05900	Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: similarity to hypothetical protein EAA58873.1 - Aspergillus nidulans
An09g05920	Function: chit33 of T. harzianum random hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Title: strong similarity to chitinase precursor chit33 - Trichoderma harzianum; See PMID 8575023
An09g05930	Remark: C-terminally truncated ORF due to contig border.
An09g05940	Function: the purified enzyme catalyzes the conversion of reduced glutathione to its disulfide form,with concomitant consumption of O2 and release of H2O2.; Gene-ID: Sox; See PMID 10542195; See PMID 3427078
An09g05950	Title: strong similarity to plasma membrane ATPase PMA1 - Kluyveromyces lactis; plasma membrane; See PMID 7730265
An09g05970	Remark: the predicted ORF shows similarity to several cytosolic glutamate--tRNA ligases from different species.; Title: strong similarity to cytosolic glutamate--tRNA ligase - Arabidopsis thaliana; cytoplasm
An09g05980	Title: similarity to ribosomal protein of the large subunit L1 rplA - Escherichia coli; See PMID 381841
An09g05990	Title: similarity to hypothetical protein CAD71232.1 - Neurospora crassa
An09g06000	Remark: blast hits are caused by repetitive sequence-motives.; Title: weak similarity to hypothetical membrane protein YJR151c - Saccharomyces cerevisiae
An09g06010	Similarity: YIL003w of S. cerevisiae belongs to the mrp/nbp35 family of ATP-binding proteins.; Title: strong similarity to hypothetical membrane protein YIL003w - Saccharomyces cerevisiae
An09g06020	Function: S. cerevisiae mutations in SHP1 markedly reduce catalytic activity of the phosphoprotein phosphatase 1 (PP1) catalytic subunit Glc7 without noticeably affecting the level or distribution of the protein.; Function: S. cerevisiae mutations in SHP1 totally block sporulation and slightly slow cell proliferation and show deficient glycogen accumulation.; Function: the S. cerevisiae SHP1 is involved in the glycogen metabolism.; Function: the human homologe of yeast SHP1, p47 binds to the ATPase p97 which is involved in the heterotypic fusion of transport vesicles with their target membranes and the homotypic fusion of membrane compartments.; Remark: the systematic name for SHP1 of S. cerevisiae is YBL058w.; Title: strong similarity to regulator of phosphoprotein phosphatase 1 Shp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9214505; See PMID 7891699
An09g06030	Complex: S. cerevisiae Oxa1p is a constituent of an oligomeric complex.; Function: S. cerevisiae Oxa1p appears to be involved in the insertion of pairs of transmembrane segments into the inner membrane leading to the export of hydrophilic segments between them.; Function: S. cerevisiae Oxa1p mediates the export of mitochindrial encoded genes like Cytochrome oxidase II from the matrix.; Function: S. cerevisiae Oxa1p mediates the membrane potential-dependent export of N-terminal tails of nuclear encoded proteins from the matrix to the intermembrane space in order to locate the N termini in the intermembrane space.; Function: S. cerevisiae Oxa1p represents a component of a novel, general export machinery in the mitochondrial inner membrane.; Localization: S. cerevisiae Oxa1p spans the inner membrane of the mitochondrion five times and has an N out C in orientation.; Title: strong similarity to mitochondrial intermembrane space.export machinery component Oxa1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9482871
An09g06040	Complex: TFIID is a multisubunit complex consisting of the TATA-binding protein (TBP) and several TBP-associated factors (TAFs).; Function: TFIID recognizes the core promoter and supplies a scaffolding upon which the rest of the transcriptional machinery can assemble.; Function: the basal transcription factor TFIID coordinates the combined activities of more than 70 polypeptides required for synthesis of mRNA by RNA polII.; Similarity: the predicted ORF is N- and C-terminally extented compared to putative homologues of other species.; Title: similarity to subunit of transcription initiation factor TFIID TAFII28 - Homo sapiens; nucleus; See PMID 10721692; See PMID 8820923
An09g06050	Catalytic activity: S-adenosylmethionine decarboxylases catalyse the reaction,S-adenosyl-L-methionine <=> (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO(2).; Function: N. crassa Spe-2 catalyzes the formation of decarboxylated AdoMetDC, a precursor of the polyamines spermidine and spermine.; Remark: S-adenosylmethionine decarboxylases is a potentially important drug target for the chemotherapy of cancer and parasitic diseases.; Title: strong similarity to S-adenosylmethionine decarboxylase spe-2 - Neurospora crassa; cytoplasm; See PMID 10852489; See PMID 1764068
An09g06060	Catalytic activity: phospholipases from the A1 type catalyse the reaction, Phosphatidylcholine + H(2)O <=> 2-acylglycerophosphocholine + a fatty acid anion.; Remark: ORF 5' truncated due to end of Contig.; Title: weak similarity to phospholipase A1 -Polistes annularis [truncated ORF]; See PMID 6712224
An09g06070	Complex: binds tightly to TAFII-250 and also directly interacts with TAFII-40.; Function: the X. laevis transcription factor IID 60 KD subunit p80 plays a central role in mediating promotor responses to various activators and repressors.; Similarity: belongs to the TAF2E family.; Title: strong similarity to subunit of transcription initiation factor TFIID p80 - Xenopus laevis; nucleus; See PMID 7590360
An09g06080	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An09g06090	Function: the Streptomyces sp. pentalenene synthase catalyzes the cyclization of farnesyl diphosphat to the tricyclic sesquiterpene hydrocarbon pentalenene.; Pathway: the enzyme pentalenene synthase is involved in the biosynthesis of pentalenolactone and related antibiotics.; Title: strong similarity to pentalenene synthase -Streptomyces sp.; See PMID 8180213
An09g06100	Phenotype: disruption of the A. thaliana AtSPO11-1 protein results in altered meiotic progression, few bivalents, no fully synapsed chromosomes during prophase I and chromosomes segregated randomly in meiosis I.; Remark: a putative sequencing error results in an premature STOP-codon.; Remark: the SPO11 protein from S. cerevisiae catalyses DNA double-strand breaks (DSBs) that initiate meiotic recombination.; Title: similarity to hypothetical double strand break catalysing AtSPO11-1 - Arabidopsis thaliana [putative sequencing error]; putative sequencing error; See PMID 11157765
An09g06110	Complex: the S. pombe UbcP4 interacts with chk1 during the G2/M-phase transition and with cut9 during the metaphase/anaphase transition.; Function: the S. pombe UbcP4 protein is necessary for cell cycle progression at two phases, the G2/M and metaphase/anaphase transition.; Title: strong similarity to ubiquitin conjugating enzyme ubcp3p - Schizosaccharomyces pombe; See PMID 9154838
An09g06120	Function: the M. musculus Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced bidirectional transbilayer movement of plasma membrane phospholipids in activated, injured, or apoptotic cells.; Title: similarity to cDNA phospholipid scramblase 1 - Mus musculus; See PMID 10930526
An09g06130	Title: similarity to hypothetical protein CAD21257.1 - Neurospora crassa
An09g06140	Remark: L2 of S. cerevisiae is also called YmL2,YMR6, MRPL2, MRP7, YNL005C, or N2007.; Remark: L2 of S. cerevisiae is essential for ribosomal function.; Similarity: the ORF is shorter than L2 of S. cerevisiae (283 compared to 371 amino acids) and the homology between the two proteins spans only a stretch of about 130 amino acids.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2851722
An09g06150	Function: epistasis analysis with other S. pombe checkpoint mutants indicates that rhp9 acts in a process involving the checkpoint rad genes and that the rhp9 mutant is phenotypically very similar to chk1.; Function: the S. pombe rhp9 protein (S. cerevisiae Rad9 homologue, also known as Crb2) is required for the DNA damage checkpoint, but not the replication checkpoint.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein (aa952 - aa1349) to the C-terminal part of the S. pombe protein.; Title: similarity to DNA damage checkpoint protein rhp9p - Schizosaccharomyces pombe; See PMID 10488332; See PMID 9153313
An09g06160	Complex: the S. cerevisiae SEN2 forms a tetrameric enzyme with two active sites.; Function: SEN2 catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.; Function: the S. cerevisiae SEN2 splices the tRNA precursors which is essential for the production of mature tRNA.; Remark: SEN2 of S. cerevisiae is also known as YLR105C.; Remark: the systematic name of SEN2 is YLR105C.; Title: strong similarity to tRNA splicing endonuclease beta-subunit Sen2 - Saccharomyces cerevisiae; See PMID 9200603
An09g06170	Similarity: the ORF has also a match against an A. niger EST SEQ ID NO:3997 from patent WO200056762-A2.; Title: strong similarity to hypothetical protein YHR072w-a - Saccharomyces cerevisiae
An09g06180	Function: HP-10 is considered to be a new regulatory phosphorylation protein because it has no intrinsic kinase activity.; Function: bacteria expressing the HP-10 encoded protein were found to have a dramatic increase in endogenous phosphorylated proteins.; Title: similarity to phosphorylation regulatory protein HP-10 - Homo sapiens; See PMID 1791827
An09g06190	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An09g06200	Localization: PTH11 of M. grisea was localized as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: strong similarity to transmembrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An09g06210	Pathway: the lovastatin biosynthesis is part of the polyketide metabolism. Two type I polyketide synthase genes are required: LNKS and LovC.; Remark: the fungal metabolite lovastatin and its derivatives are widely prescribed cholesterol-lowering drugs that act as potent inhibitors of (3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMG-CoA reductase).; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to hypothetical regulator protein of the lovastatin biosynthesis - Aspergillus terreus; See PMID 10334994
An09g06220	Pathway: the lovastatin biosynthesis is part of the polyketide metabolism. Two type I polyketide synthase genes are required: LNKS and LovC.; Remark: the fungal metabolite lovastatin and its derivatives are widely prescribed cholesterol-lowering drugs that act as potent inhibitors of (3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMG-CoA reductase).; Similarity: the N-terminal region of the predicted A. niger protein contains a Prokaryotic membrane lipoprotein lipid attachment site.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus
An09g06230	Similarity: this gene shows also similarity to the hypothetical protein encoded by An13g01740 Aspergillus niger.; Title: similarity to hypothetical protein 25D9-9 -Aspergillus fumigatus
An09g06240	Title: similarity to hypothetical protein encoded by An09g06370 - Aspergillus niger
An09g06250	Function: the S. cerevisiae homolog aminopeptidase I is a vacuolar enzyme, which catalyzes the removal of amino acids from the NH2 terminus of peptides and proteins.; Title: strong similarity to vacuolar aminopeptidase Ysci - Saccharomyces cerevisiae; vacuole; See PMID 2651436; See PMID 7750534
An09g06260	Title: similarity to mutanase mutA - Aspergillus oryzae; See PMID 10636904
An09g06270	Title: strong similarity to hypothetical glutathione-dependent formaldehyde dehydrogenase SPBC1198.01 - Schizosaccharomyces pombe
An09g06280	Title: strong similarity to hypothetical transcription factor BAB47239.1 - Aspergillus oryzae
An09g06290	Title: similarity to hypothetical protein SPAC1B2.02c - Schizosaccharomyces pombe
An09g06300	Remark: the adrenodoxin precursor protein of Sus scrofa transfers electrons to cytochromes P450 of the vitamin D pathway.; Title: similarity to hypothetical adrenodoxin precursor protein - Sus scrofa; localisation:mitochondrion
An09g06310	Title: similarity to hypothetical protein YPR143w -Saccharomyces cerevisiae
An09g06320	Function: This protein is one component involved in the translocation of a nascent polypeptide from the cytoplasm into the endoplasmic reticulum.; Gene-ID: srpA; cytoplasm; See PMID 8566805
An09g06330	Title: similarity to protein fragment SEQ ID NO:5981 from patent EP1108790-A2 - Corynebacterium glutamicum
An09g06340	Title: strong similarity to immunogenic protein #11392 from patent WO200181581-A2 - Propionibacterium acnes
An09g06350	Function: the snaD gene of Aspergillus nidulans suppresses mutations in the cytoplasmatic dynein heavy chain gene nudA1, which inhibit nuclear migration, colony growth and asexual sporulation (conidiation).; Title: strong similarity to protein snaD -Aspergillus nidulans; See PMID 10821171
An09g06360	Remark: similarities correspond to multiple serine repeats.
An09g06370	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein 3 from Rhizobium leguminosarum.; Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger
An09g06380	Title: strong similarity to hypothetical protein brt1 - Schizophyllum commune
An09g06390	Title: strong similarity to lipase LipP -Pseudomonas sp.
An09g06400	Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Remark: disruption of Aspergillus nidulans chiA gene substantially decreased germination frequency and hyphal growth rate.; Title: strong similarity to chitinase chiA -Aspergillus nidulans; See PMID 9501518
An09g06410	Remark: similarities correspond partially to multiple glutamine, glycine and serine repeats.; Title: similarity to hypothetical protein EAA66742.1 - Aspergillus nidulans
An09g06420	Function: cephalosporin C is a beta-lactam antibiotic.; Similarity: importantly, the ORF shows additionally strong similarity to nuclease O nucO of A. oryzae and to alpha-methylacyl-CoA racemases, but non of the sequences show significant similarity to the cephalosporin C biosynthesis protein.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP06038763-A -Acremonium chrysogenum; See PMID 10592528; See PMID 1369089
An09g06430	Title: strong similarity to hypothetical protein AAH28592.1 - Homo sapiens
An09g06440	Complex: yeast CAC1, CAC2 and CAC3 form the chromatin assembly factor-I (CAF-I).; Function: RLF2 (Rap1p localization factor-2) is required for the normal distribution of the telomere-binding Rap1p protein within the nucleus. Rlf2p facilitates the efficient and timely assembly of histones into telomeric chromatin.; Phenotype: in rlf2 mutants, telomeric chromatin is perturbed, telomeric silencing is reduced and Rap1p localization is altered. in cells lacking CAF-I, the silent mating loci are derepressed partially.; Remark: deletion of any CAC gene causes an increase in sensitivity to ultraviolet radiation, without significantly increasing sensitivity to gamma rays. deletion of CAC genes also strongly reduces silencing of genes adjacent to telomeric DNA.; Similarity: the predicted A. niger protein shows strong similarity to subunit p90 of chromatin assembly factor-I (RLF2) of S. cerevisiae and similarity to several proteins described as (putative) chromatin assembly factor subunits. the A. niger protein sequence is rich in glutamic acid and lysine. the systematic name of yeast RLF2 is YPR018w. RLF2 is also known as CAC1.; Title: strong similarity to chromatin assembly factor-I (CAF-I) p90 subunit Rlf2 - Saccharomyces cerevisiae; nucleus; See PMID 9030687; See PMID 9030688; See PMID 9436982
An09g06450	Remark: the ORF is truncated due to border of contig.; Title: strong similarity to hypothetical protein CAD71235.1 - Neurospora crassa [truncated ORF]
An09g06460	Remark: the predicted A. niger gene is identical to the A. niger patent EST WO200056762-A2 from bp 511 to bp 882.; Title: strong similarity to hypothetical Glc8 related protein CAD21258.1 - Neurospora crassa
An09g06470	Remark: ORF classified questionable due to length below 100 aa and no significant blastp similarity.; Title: questionable ORF
An09g06480	Title: similarity to hypothetical protein YJL145w -Saccharomyces cerevisiae
An09g06490	Title: strong similarity to oxide squalene cyclising enzyme from patent JP08308568-A - Rattus rattus; See PMID 8604986
An09g06500	Complex: Sgt1p physically associates with Skp1p in vivo and in vitro, and thus also associates with SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase.; Function: the S. cerevisiae Sgt1p is required for assembling the yeast kinetochore complex, CBF3, via activation of Ctf13p.; Remark: human SGT1 rescues an sgt1 null mutation in S. cervisiae, suggesting that the function of SGT1 is conserved in evolution.; Title: strong similarity to protein Sgt1 -Saccharomyces cerevisiae; See PMID 10445024
An09g06510	Remark: the H. sapiens patent transmembrane protein WO200056891-A2 is involved in various human disorders.; Title: strong similarity to human transmembrane from patent WO200056891-A2 - Homo sapiens
An09g06520	Remark: the H. sapiens SIRT4 belongs to a group of four human SIRT proteins (SIRT1-SIRT5).; Remark: the five human sirtuins are widely expressed in fetal and adult tissues.; Similarity: the H. sapiens sirtuin type proteins are closly related to yeast Sir2 proteins, which are regulating epigenetic gene silencing and as a possible antiaging effect, they suppresses recombination of rDNA.; Title: strong similarity to cDNA sirtuin type 4 protein SIRT4 - Homo sapiens; See PMID 10381378
An09g06530	Remark: Cyclin-dependent kinase 2 (Cdk2) controls the transition from the G1 to the S phase in the mammalian cell cycle.; Title: strong similarity to cyclin dependent kinase 2-alpha - Rattus rattus; deleted EC_number 2.7.1.37; See PMID 7862443
An09g06540	Function: the S. cerevisiae NNF1 is an essential yeast gene required for proper spindle orientation,nucleolar and nuclear envelope structure and mRNA export.; Phenotype: the S. cerevisiae NNF1 null mutant is inviable; cells depleted of Nnf1p or containing a temperature-sensitive nnf1 mutation have elongated microtubules and become bi- and multinucleate.; Remark: the systematic name of S. cerevisiae NNF1 is YJR112W.; Title: similarity to protein Nnf1 - Saccharomyces cerevisiae; See PMID 9247195
An09g06550	Title: similarity to hypothetical protein SPAC926.02 - Schizosaccharomyces pombe
An09g06560	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An09g06570	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An09g06580	Title: strong similarity to ras-GTPase-activating protein SH3-domain binding protein G3BP - Mus musculus; See PMID 9575347
An09g06590	Function: prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins.; Function: the sspB protein is a Hsp90 heat shock protein.; Gene-ID: sspB; Remark: the matched sequence of sspB from A. niger was identified by a BLAST search with the new EMBL entry CAA72292.
An09g06600	Remark: blast hits result from repetitive sequences.
An09g06610	Title: strong similarity to hypothetical protein EAA26720.1 - Neurospora crassa
An09g06630	Function: analysis of N. crassa nuc-2 and nuc-1; nuc-2 strains transformed by the nuc-1+ gene suggests that phosphate directly affects the level or activity of the negative regulatory factor(s) controlling phosphorus acquisition.; Title: similarity to transcription activator nuc-1 -Neurospora crassa; nucleus; See PMID 2146493
An09g06640	Function: human TFIIE consists of two subunits TFIIE-alpha T2EA_HUMAN and TFIIE-beta T2EB_HUMAN and joins the preinitiation complex after RNA polymerase II and TFIIF.; Function: the general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors.; Similarity: restricted to TFIIE alpha subunit.; Title: similarity to DNA-directed RNA polymerase III 82 KD subunit Rpc82 - Saccharomyces cerevisiae; nucleus; See PMID 8407894
An09g06650	Function: the core protein II is an bifunctional enzyme, that acts as mitochondrial processing peptidase as well as part of the respiration chain b/c1 complex.; Title: strong similarity to core protein II of ubiquinol--cytochrome c reductase CAA42214.1 - Bos primigenius taurus; localisation:mitochondrion
An09g06660	Title: questionable ORF
An09g06670	Function: S. cerevisiae enzyme is essential for mitochondrial function in the absence of Abf2p.; Function: it associated with mitochondrial DNA in vivo.; Function: it is a component of the mitochondrial nucleoid structure.; Function: it is required for maintenance of mtDNA.; Function: it may function as a member of the protein machinery for the mitochondrial inner membrane attachment site for mitochondrial DNA during replication and segregartion of the mitochondrial genome.; Title: strong similarity to suppressor gene of mitochondrial histone Yhm2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9742088
An09g06680	Catalytic activity: converts Citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: up to 11-fold overproduction of citrate synthase did not increase the rate of citric acid production by the fungus, suggesting that citrate synthase contributes little to flux control in the pathway involved in citric acid biosynthesis by a non-commercial strain.; Gene-ID: citA; Localization: in addition to an N-terminal mitochondrial import signal, a peroxisomal target sequence (AKL) was found at the C-terminus of the protein, but it is unclear whether both signals are functional in vivo.; localisation:mitochondrion; See PMID 10689162
An09g06690	Title: similarity to hypothetical protein related to potassium channel subunit MiRP3 B1D1.370 - Neurospora crassa
An09g06700	Function: many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids.; Title: similarity to protein involved in regulation of nuclear pre-mRNA abundance Nrd1 - Saccharomyces cerevisiae; nucleus; See PMID 8943355; See PMID 9234673
An09g06710	Catalytic activity: it converts o-acetyl-l-homoserine + methanethiol = l-methionine + acetate.; Cofactor: pyridoxal phosphate.; Function: A. nidulans enzyme transforms o-acetylhomoserine into homocysteine.; Similarity: belongs to the trans-sulfuration enzymes family.; Title: strong similarity to O-acetylhomoserine (thiol)-lyase cysD - Aspergillus nidulans; cytoplasm
An09g06720	Remark: ORF might be questionable because of large intron.; Title: weak similarity to hypothetical protein B13I18.100 - Neurospora crassa
An09g06730	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to lysine-specific high-affinity permease Lyp1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9348664
An09g06740	Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Function: S. cerevisiae Faa2 is involved in esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It preferentially acts on c9:0-c13:0 fatty acids although c7:0-c17:0 fatty acids are tolerated. Its optimum activity is found at 25 degrees celsius.; Remark: alternate names for S. cerevisiae Faa2: Fam1 or YER015W.; Title: strong similarity to long-chain-fatty-acid--CoA ligase Faa2 - Saccharomyces cerevisiae; See PMID 8027063; See PMID 8206942
An09g06750	Title: strong similarity to hypothetical protein B13I18.120 - Neurospora crassa
An09g06760	Remark: alternate names for Drosophila eld: eyelid or osa.; Similarity: the ORF encoded protein shows significant similarity to the hypothetical protein B13I18. 20 Neurospora crassa.; Similarity: the similarities of the ORF encoded protein to hits with an e-Val less than 2e-11 are mainly based on repetitive structures.; Title: weak similarity to transcription factor eyelid eld - Drosophila melanogaster
An09g06770	Title: strong similarity to hypothetical protein B13I18.130 - Neurospora crassa
An09g06780	Remark: Depletion of the Candida boidinii PMP47 gene results in a retarded growth on oleate and a complete loss of growth on methanol, pmp47delta cells show reduced numbers peroxisomes. The activity of one of the methanol-induced peroxisome matrix enzymes,dihydroxyacetone synthase (DHAS), can not be detected.; Similarity: the peroxisomal membrane protein 47 (Pmp47) from Candida boidinii belongs to the mitochondrial carrier family.; Title: strong similarity to peroxisomal membrane protein 47 Pmp47 - Candida boidinii; peroxisome; See PMID 8698821
An09g06790	Gene-ID: sgrB;yptA; Similarity: strong similarity to the GTP-binding protein Rab1 from Homo sapiens.; See PMID 11489135
An09g06800	Cofactor: Zinc.; Function: S. cerevisiae Ape2 is involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.; Remark: alternate names for S. cerevisiae Ape2: Aminopeptidase II, YscII, Lap1 or YKL157W.; Similarity: S. cerevisiae Ape2 belongs to peptidase family M1 (zinc metalloprotease) which is also known as the PepN subfamily.; Title: strong similarity to leucyl aminopeptidase Ape2 - Saccharomyces cerevisiae; See PMID 1765107; See PMID 3286257; See PMID 6352682
An09g06810	Complex: the SSL1 gene of S. cerevisiae encodes a subunit of the RNA polymerase II transcription factor TFIIH (factor b).; Title: strong similarity to subunit of transcription initiation factor TFIIH Ssl1 - Saccharomyces cerevisiae; nucleus; See PMID 11007479; See PMID 7891722
An09g06820	Title: similarity to hypothetical protein B17C10.80 - Neurospora crassa
An09g06830	Function: the Pumilio protein from D. melanogaster is involved in translational regulation of hunchback (hb) mRNA, which is essential for posterior patterning of the Drosophila embryo. This regulation is mediated by sequences in the 3'-untranslated region of hb mRNA (the Nanos response elements or NREs.). Nonos and Pumilio are the two important trans-acting factors.; Similarity: the ORF encoded protein belongs to the Pumilio/Mpt5 family.; Title: similarity to RNA binding protein Pumilio Pum - Drosophila melanogaster; cytoplasm; See PMID 10541556; See PMID 10662662
An09g06840	Function: the S. cerevisiae homolog Sly41p is likely to be involved in vesicular ER to Golgi transport. Sly41p was shown to suppress a functional loss of the essential gene YPT1, a member of the RAS superfamily involved in this particular transport step.; Similarity: S. cerevisiae Sly41p has similarity to the triose phosphate translocator family.; Title: strong similarity to protein involved in ER to Golgi transport Sly41 - Saccharomyces cerevisiae
An09g06850	Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Function: the NDUFS1 gene from Bos taurus encodes for the largest subunit of respiratory chain complex I and it is a component of the iron-sulfur (IP) fragment. It may form a part of the active site where NADH is oxidized.; Title: strong similarity to 78 kD subunit of NADH:ubiquinone reductase NDUFS1 - Bos taurus; localisation:mitochondrion; See PMID 2514801
An09g06860	Similarity: the ORF encoded protein shows significant similarity to the protein related to the mitotic apparatus protein p62 (protein B13N20. 180) from Neurospora crassa.; Title: similarity to hypothetical mitotic apparatus protein p62 related protein CAB91383.2 - Neurospora crassa
An09g06870	Complex: the S. pombe byr4 protein interacts with the GTPase Spg1, which is involved in the regulation of septation and constriction of the actomyosin ring for cell division in fission yeast. Spg1 is a member of the Ras superfamily.; Function: the S. pombe byr4 protein is involved in coordination between karyokinesis and cytokinesis in the cell division cycle.; Remark: null alleles of byr4 (S. pombe) cause cell cycle arrest in late mitosis and permit multiple rounds of septation.; Title: similarity to dosage-dependent cytokinesis inhibitor byr4p - Schizosaccharomyces pombe; See PMID 8682866; See PMID 9638658; See PMID 10196225
An09g06890	Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for S. cerevisiae Mig2: Mlz1 or YGL209W.; Title: weak similarity to transcription co-repressor Mig2 - Saccharomyces cerevisiae [truncated ORF]
An14g00010	Function: srgA mutants displayed a twofold increase in their hyphal diameter, unusual apical branching and strongly reduced protein secretion during growth on glucose.; Gene-ID: srgA; Similarity: strong similarity to the GTP-binding protein SAS1 from D. discoideum.; See PMID 11489135
An14g00020	Function: S. cerevisiae homolog is essential and an allelic form shows resistance to the drug diazaborine in S. cerevisiae.; Remark: S. cerevisiae homolog Afg2p is a AAA (ATPases associated to a variety of cellular activities) class ATPase similar to the CDC48 gene product.; Title: strong similarity to AAA class ATPase Afg2 -Saccharomyces cerevisiae
An14g00030	Complex: RNPS1 of H. sapiens is found in a single complex of approximately 335 kDa. Four other proteins of the complex were identified as the splicing-associated factors SRm160, DEK, the mRNA-associated shuttling protein Y14 and the mRNA export factor REF.; Function: Recombinant human RNPS1 expressed in baculovirus functionally synergizes with SR proteins and strongly activates splicing of both constitutively and alternatively spliced pre-mRNAs.; Remark: RNPS1 of H. sapiens is a RNA-binding protein.; Title: strong similarity to general activator of pre-mRNA splicing RNPS1 - Homo sapiens; nucleus
An14g00040	Function: A. nidulans uvsB and uvsD belong to the same epistasis group of DNA repair mutants and are likely to control cell cycle checkpoint responses to DNA damage and incomplete replication. They are also involved in septum formation and regulation of gene expression. UVSB probably functions as the central regulator of the A. nidulans DNA damage response.; Similarity: The A. nidulans uvsB gene is shown to encode a rad3/ATR homologue, a component of the nucleotide excision repairosome.; Title: strong similarity to ATM-related kinase required for DNA damage response uvsB - Aspergillus nidulans
An14g00050	Function: S. cerevisiae homolog Tad2p and S. c. Tad3p together convert adenosine at pos. 34 of tRNA-Ala to inosine.; Title: similarity to tRNA-specific adenosine deaminase Tad2 - Saccharomyces cerevisiae
An14g00060	Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol.; Function: transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Similarity: the N. crassa homolog is the 21 kDa subunit of NADH:ubiquinone oxidoreductase (complex I) and is a nuclear-coded component of its hydrophobic arm.; Title: strong similarity to 20.9 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion
An14g00070	Title: weak similarity to hypothetical protein SPBC30D10.04 - Schizosaccharomyces pombe
An14g00080	Catalytic activity: S. cerevisiae homolog Srm1p is Gdp/GTP exchange factor for Gsp1p/Gsp2p.; Function: S. cerevisiae homolog is involved in yeast pheromone response pathway and in mRNA metabolism.; Remark: S. cerevisiae homolog alternative gene names: PRP20, MTR1.; Remark: contains regulator of chromosome condensation (RCC1) signature.; Title: strong similarity to pheromone response pathway suppressor Srm1 - Saccharomyces cerevisiae; nucleus
An14g00090	Catalytic activity: catalyzes the reduction of 2,4 diamino-6-ribitylamino-4(3H)-pyrimidine 5'-phosphate by NADPH to yield DRTP.; Function: S. cerevisiae Rib7p is HTP reductase involved in riboflavin biosynthesis.; Pathway: third step of riboflavin biosynthesis.; Remark: significantly longer than S. cerevisiae homolog protein Rib7p.; Title: similarity to riboflavin biosynthesis protein Rib7 - Saccharomyces cerevisiae
An14g00100	Complex: S. cerevisiae homolog interacts with the Nsp1p complex which is involved in nucleocytoplasmic transport.; Function: S. cerevisiae homolog is required for nuclear pore formation.; Localization: S. cerevisiae homolog is localized in the nuclear pore complex.; Title: strong similarity to nucleoporin-interacting protein Nic96 - Saccharomyces cerevisiae; nucleus
An14g00110	Title: similarity to hypothetical protein YJL003w -Saccharomyces cerevisiae
An14g00130	Function: the S. pombe homolog encodes a nonreceptor type protein tyrosine phosphatase that negatively regulates mitosis.; Title: strong similarity to protein-tyrosine-phosphatase pyp1p - Schizosaccharomyces pombe
An14g00150	Similarity: the ORF shows strong similarity to EST an_3574 from Aspergillus niger.; Title: similarity to hypothetical protein B24H17.110 - Neurospora crassa
An14g00160	Catalytic activity: K. pneumoniae rbtK catalyzes phosphorylation of D-ribulose to D-ribulose-5-phosphate.; Function: the K. pneumoniae homolog is a D-ribulokinase; Pathway: pentose-phosphate pathway; Title: strong similarity to D-ribulokinase rbtK -Klebsiella pneumoniae
An14g00170	Function: one mechanism reported for H+ transport mediated by Ca2+ is an ATP-dependent Ca2+/H+ antiporter which is catalyzed by (Ca2+ + Mg2+)-ATPase in the plasma membrane.; Similarity: the S. cerevisiae homolog shows similarities to other Ca2+/H+ antiporter.; Title: strong similarity to hypothetical Ca2+/H+ antiporter YNL321w - Saccharomyces cerevisiae; plasma membrane
An14g00180	Complex: RPT6 is a protein of the 19S particle.; Function: RPT6 is an ATPase with regulatory function in the proteasome.; Localization: By immunofluorescence RPT6 was determined to be localized almost exclusively to the nucleus throughout the cell cycle.; Remark: The 26 S proteasome of eukaryotes consists of the 20S core protease and two 19S particles and is responsible for the degradation of proteins targeted for proteolysis by the ubiquitin system.; Remark: The two 19S particles mediate the binding and unfolding of a substrate protein before its transfer to the interior of the 20S core.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt6 - Saccharomyces cerevisiae; See PMID 10419517; See PMID 10688918
An14g00190	Title: weak similarity to hypothetical protein At2g17590 - Arabidopsis thaliana
An14g00200	Remark: the encoded protein shows also weak similarities to several ubiquitin fusion-degradation 1-like proteins.; Title: strong similarity to protein fragment SEQ ID NO:48474 from patent EP1033405-A2 - Arabidopsis thaliana
An14g00210	Complex: Yip1 specifically binds to the transport GTPases Ypt1p and Ypt31p.; Function: Yip1p has a role in recruiting the two GTPases Ypt1p and Ypt31p to Golgi target membranes in preparation for fusion.; Golgi; Localization: According to subcellular fractionation and indirect immunofluorescence, Yip1 is located to Golgi membranes at steady state.; Title: similarity to Golgi membrane protein Yip1 -Saccharomyces cerevisiae; See PMID 9724632
An14g00220	Title: strong similarity to hypothetical protein SPAC17C9.06 - Schizosaccharomyces pombe
An14g00230	Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.; Localization: UBC6 is an integral membrane protein that localizes to the endoplasmic reticulum (ER), with the catalytic domain facing the cytosol.; Pathway: ER degradation.; Remark: Ubiquitin-conjugating enzymes function in selective proteolysis pathways and catalyse the covalent attachment of ubiquitin to proteolytic substrates. S. cerevisiae Ubc6p is a ubiquitin conjugating enzyme targeting unfolded or misfolded ER lumenal proteins for retrograde transport across the ER membrane and subsequent degradation by the proteasome.; Title: strong similarity to ubiquitin conjugating enzyme Ubc6 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8396728
An14g00240	Catalytic activity: Holocytochrome c = apocytochrome c + heme.; Remark: In the reverse direction, cyt-2 catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.; Similarity: cyt-2 shows homology to the yeast cytochrome c heme lyase.; Title: strong similarity to holocytochrome-c synthase cyt-2 - Neurospora crassa; See PMID 2572587
An14g00250	Title: strong similarity to hypothetical membrane protein YPL109c - Saccharomyces cerevisiae
An14g00260	Function: GDS (GDP dissociation stimulator) from bovine brain cytosol is a regulatory protein that stimulates the GDP/GTP exchange reaction of smg p21s (ras p21-like GTP-binding proteins) by stimulating the dissociation of GDP from and the subsequent binding of GTP to them.; Title: similarity to stimulatory GDP/GTP exchange protein GDS - Bos taurus; See PMID 1901951; See PMID 2118909
An14g00270	Title: weak similarity to dolichol-phosphate-mannose synthase DPM3 - Homo sapiens
An14g00280	Title: strong similarity to hypothetical protein YJR133w - Saccharomyces cerevisiae
An14g00290	Function: The mae1 gene encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; See PMID 8750236
An14g00300	Function: Ayr1p of S. cerevisiae catalyzes the biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway by NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610
An14g00310	Catalytic activity: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.; Localization: Immunocytochemical experiments suggest that succinyl-CoA synthetase from Neocallimastix frontalis is located in the hydrogenosomal matrix.; Pathway: Substrate level phosphorylation step of the tricarboxylic acid cycle.; Title: strong similarity to beta-succinyl CoA synthase precursor scsB - Neocallimastix frontalis; See PMID 9003318
An14g00330	Function: SFL1 of S. cerevisiae is involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). mutations in SFL1 of S. cerevisiae cause constitutive cell aggregation.; Similarity: the N-terminal section of SFL1 of S. cerevisiae is similar to the heat shock transcription factor (HSF) family. the C-terminal section of SFL1 of S. cerevisiae is similar to the myc family of helix-loop-helix transcription factors.; Title: strong similarity to flocculation suppression protein Sfl1 - Saccharomyces cerevisiae; See PMID 2697640
An14g00340	Remark: the similarity to the microtubule-associated protein homologue of D. melanogaster is due to repetitive sequence in the ORF.; Title: weak similarity to hypothetical protein AAN24427.1 - Bifidobacterium longum
An14g00350	Title: similarity to hypothetical protein YPL107w -Saccharomyces cerevisiae
An14g00370	Remark: ribosomal proteins L13 of S. cerevisiae and A. thaliana were overexpressed in E. coli by tRNA-assisted overproduction.; Similarity: L13a of R. norvegicus is related to the S. cerevisiae ribosomal proteins that have been provisionally designated rp22 and rp23 and to the eubacterial and archaebacterial family of L13 ribosomal proteins.; Similarity: the ORF of A. niger is highly similar to several ESTs (AA787556; AI212136; AA784304; AI327985; ANI237050) of A. nidulans.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L13 - Rattus norvegicus; cytoplasm; See PMID 8198561; See PMID 10733889
An14g00380	Similarity: protein homologues are due to repetitive sequence of the ORF.; Title: weak similarity to hypothetical protein encoded by ORF L6202.3 - Leishmania major
An14g00390	Remark: a putative human homolog of soc-2 of C. elegans, SHOC-2, is expressed in all tissues assayed, and SHOC-2 protein is cytoplasmically localized.; Remark: soc-2 of C. elegans suppresses the activity of an activated form of the EGL-15 FGF receptor.; Remark: the c-terminus of the ORF of A. nidulans is conserved in non-characterized ORFs derived from several divergent species.; Similarity: Similarity to leucine-rich repeat proteins is due to high content of leucine.; Title: strong similarity to leucine-rich repeat protein soc-2 - Caenorhabditis elegans; cytoplasm; See PMID 9618511
An14g00400	Title: similarity to hypothetical protein SPAC22E12.18 - Schizosaccharomyces pombe
An14g00410	Remark: a transcript of the actin-related protein of D. melanogaster was detected at all stages of development.; Remark: actin-related proteins (ARPs) have primary sequence homology to actin, have no homology to other proteins and, unlike the conventional actins, are clearly divergent.; Title: strong similarity to actin-related protein -Drosophila melanogaster; cytoskeleton; See PMID 8308899
An14g00420	Function: the RING finger/IBR motif-containing domains of HHARI of H. sapiens interact specifically with the ubiquitin-conjugating enzymes UbcH7 and UbcH8, but not with the unrelated ubiquitin-conjugating enzymes UbcH5 and UbcH1. it is not clear at present whether HHARI of H. sapiens serves simply as a substrate for UbcH7 or represents a protein with ubiquitin-protein ligase activity.; Similarity: HHARI of H. sapiens is a homologue of the Drosophila ring finger protein ariadne.; Title: similarity to UbcH 7-binding protein HHARI -Homo sapiens; See PMID 10521492
An14g00430	Function: the enzyme beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum catalyzes the reaction (s)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH.; Pathway: beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is involved in butyryl-CoA synthesis.; Remark: beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is a part of the BCS (butyryl-CoA synthesis) operon.; Remark: the ORF of A. niger is expressed in the ESTs BE760071 (97% identity) and BE759647 (96% identity).; Similarity: the enzyme beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is similar to other 3-hydroxyacyl-CoA dehydrogenases.; Title: strong similarity to 3-hydroxybutyryl-CoA dehydrogenase BHBD - Clostridium acetobutylicum; See PMID 8655474
An14g00440	Remark: strong similarity to E. nidulans mdrA, drug resistance protein.; Title: similarity to topoisomerase I interacting factor 1 Tof1 - Saccharomyces cerevisiae; See PMID 10028183
An14g00450	Title: weak similarity to filaggrin MMFIL - Mus musculus; See PMID 3680218
An14g00460	Catalytic activity: betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.; Pathway: osmoregulatory choline-glycine betaine pathway.; Remark: the E. coli protein is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase.; Title: weak similarity to betaine aldehyde dehydrogenase badH - Escherichia coli; See PMID 1879697; See PMID 1956285
An14g00470	Title: weak similarity to hypothetical proline-rich protein T20E23.180 - Arabidopsis thaliana
An14g00480	Remark: the S. cerevisiae transcription factor IIH (TFIIH) is essential both for transcription by RNA polymerase II (RNAP II) and for nucleotide excision repair (NER) of damaged DNA.; Remark: the systematic name for TFB2 of S. cerevisiae is YPL122c.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb2 - Saccharomyces cerevisiae; nucleus; See PMID 9118947; See PMID 11007479
An14g00490	Remark: novel protein similar to (predicted) human,plant, worm, yeast and archaea bacterial proteins.; Title: strong similarity to hypothetical protein SPBC31F10.02 - Schizosaccharomyces pombe
An14g00500	Remark: similarity to Superfamily I DNA helicases and helicase subunits.; Remark: weak similarity to ATPases associated with various cellular activities.; Title: strong similarity to hypothetical At2g38770 -Arabidopsis thaliana
An14g00510	Remark: in vivo and in vitro experiments demonstrate that human p84 binds preferentially to the functionally active, hypophosphorylated form of p110RB.; Remark: the amino terminus of p110RB may function in part to facilitate the binding of growth promoting factors at subnuclear regions actively involved in RNA metabolism.; Title: strong similarity to protein p84 - Homo sapiens; See PMID 7525595
An14g00520	Remark: expression was completely lacking in leaves and flowers.; Remark: in common sunflower Hahr1 expression was primarily found in dry seeds, hypocotyls and roots at stages associated with early developmental events.; Title: similarity to root-specific homeotic protein HRS1 - Helianthus annuus; See PMID 9322741; See PMID 10873798
An14g00530	Remark: in S. cerevisiae was shown that each molecule of protein contains 10 +/- 2 Cu(I).; Remark: the C-X-C repeats may coordinate copper binding.; Title: similarity to Cu-binding metallothionein CRD2 - Candida albicans; See PMID 10411649; See PMID 10940034
An14g00540	Remark: coat proteins of approximately 100-kD (adaptins) are components of the adaptor complexes which link clathrin to receptors in coated vesicles.; Title: strong similarity to alpha-adaptin C - Mus musculus; See PMID 10873829; See PMID 2564002
An14g00550	Title: strong similarity to hypothetical protein YBL036c - Saccharomyces cerevisiae
An14g00560	Remark: N-terminal truncated orf due to end of contig.; Remark: the protein shares similarity with histon deacylases.; Title: similarity to hypothetical protein YPL116w -Saccharomyces cerevisiae [truncated ORF]; See PMID 8962081
An14g00570	Catalytic activity: 5,10-Methylenetetrahydrofolate + dUMP = Dihydrofolate + dTMP.; Pathway: Pyrimidine metabolism; One carbon pool by folate; Folate biosynthesis.; Remark: mutant TS cDNA can be used in gene therapy to transfer drug resistance to human haematopoietic progenitors, thus allowing dose-intense therapy in cancer patients by protecting normal cells and preventing dose-limiting myelotoxicity.; Title: strong similarity to thymidylate synthase CATSA - Candida albicans; See PMID 10840069; See PMID 10847455; See PMID 2646281
An14g00580	Catalytic activity: tRNA guanine + queuine = tRNA queuine + guanine.; Function: by similarity the enzyme exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-asp, -asn, -his and -tyr). after this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-y1)amino)methyl)-7 -deazaguanosine).; Remark: as cofactor it binds an requires by similarity zinc and magnesium for activity.; Remark: the enzyme also catalyses the exchange of precursors of queuine and of guanine itself for guanine located in the first position of certain tRNA anticodons.; Similarity: the enzyme belongs to the queuine tRNA-ribosyltransferase family.; Title: strong similarity to queuine tRNA-ribosyltransferase tgt - Zymomonas mobilis; See PMID 8654383; See PMID 7665516
An14g00590	Remark: agrobacterium vitis is a common pathogen of grapevine. Most strains utilize tartrate, an abundant compound in grapevine.; Title: similarity to tartrate transport protein ttuB - Agrobacterium vitis; See PMID 8672817
An14g00620	Catalytic activity: release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.; Remark: Enzyme with aminopeptidase activity - used in bread or dough-improving compsns., and to reduce the bitter taste of proteins or protein hydrolysates for foodstuffs, partic. cheese or cocoa.; Remark: as a cofactor of the reaction is zinc required.; Title: strong similarity to aminopeptidase from patent WO9628542-A1 - Aspergillus oryzae; See PMID 8175799; See PMID 1550363
An14g00630	Catalytic activity: adenosine 3',5'-bisphosphate + H(2)O <=> adenosine 5'-phosphate + phosphate.; Pathway: sulfur metabolism.; Remark: dephosphorylates 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS) intermediates of the sulfate assimilation pathway.; Title: strong similarity to salt tolerance protein Met22 - Saccharomyces cerevisiae; See PMID 7809627; See PMID 8393782
An14g00640	Title: strong similarity to hypothetical protein EAA61679.1 - Aspergillus nidulans
An14g00660	Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: chsA of E. nidulans is involved in aminosugar metabolism.; Remark: the chsA disruptant of the E. nidulans grew as well as the wild-type strain, but the chsB disruptant had severe growth defects that could not be overcome by the addition of 1. 2M sorbitol as an osmotic stabilizer. these findings suggested that chsB but not chsA is essential for hyphal growth.; Title: strong similarity to chitin synthase chsA -Aspergillus nidulans; See PMID 7765508; See PMID 10906951; See PMID 1731323
An14g00670	Catalytic activity: a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Pathway: Arginine and proline metabolism; Phenylalanine metabolism; Tryptophan metabolism; Cyanoamino acid metabolism.; Remark: the enzyme acts on carbon-nitrogen bonds,other than peptide bonds In linear amides.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667
An14g00680	Remark: the protein is probably responsible for the uptake of zinc and cadmium ions.; Title: strong similarity to heavy metal ion resistance protein Zrc1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 2693940
An14g00690	Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Function: the A. nidulans homolog catA is a catalase, functioning to protect cells from different reactive oxygen species.; Induction: A. nidulans catA is induced during oxidative stress and in asexual sporulation.; Remark: as cofactors acts manganese and heme.; Title: strong similarity to catalase A catA -Aspergillus nidulans; See PMID 8598056; See PMID 10589732
An14g00700	Title: strong similarity to hypothetical ATPase HFN2B - Haematobia irritans; See PMID 8551518
An14g00710	Remark: required for polarized morphogenesis in response to pheromone signal.; Title: strong similarity to bud emergence mediator Bem1 - Saccharomyces cerevisiae; See PMID 1538785
An14g00740	Title: similarity to hypothetical protein T16B24.2 -Arabidopsis thaliana
An14g00750	Title: similarity to defective in vacuolar protein sorting protein Vps36 - Saccharomyces cerevisiae; See PMID 8649377; See PMID 9265642
An14g00760	Similarity: the predicted ORF shows weak similarity to some neurofilament proteins.
An14g00780	Title: similarity to hypothetical protein PH0854 -Pyrococcus horikoshii
An14g00800	Similarity: the similarities are due to repetetive sequences.; Title: similarity to hypothetical protein CAC38347.1 - Schizosaccharomyces pombe
An14g00810	Title: strong similarity to hypothetical protein EAA61688.1 - Aspergillus nidulans
An14g00820	Title: weak similarity to subunit K of the dimeric form of mitochondrial F1F0-ATP synthase Atp19 -Saccharomyces cerevisiae
An14g00830	Function: PPT1 of B. ammoniagenes belongs to the group of holo-acyl carrier protein synthases (ACPS), that transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to Ser-36 of acyl carrier protein (ACP).; Function: PPT1 of B. ammoniagenes in vitro activates fatty acid synthase apoFAS-A.; Similarity: the ORF shows similarity to holo-[acyl-carrier-protein] synthase from some species.; Title: similarity to phosphopantethiene protein transferase PPT1 - Brevibacterium ammoniagenes; See PMID 9346306
An14g00840	Catalytic activity: L-Histidinol phosphate + H2O = L-Histidinol + Orthophosphate; Function: catalyzes ninth step in histidine biosynthetic pathway.; Pathway: histidine biosynthesis.; Title: strong similarity to histidinol-phosphatase His2 - Saccharomyces cerevisiae; See PMID 8056323
An14g00850	Catalytic activity: peptidylproline (omega=180) = peptidylproline (omega=0).; Function: FKBP12 of yeast is a peptidyl-prolyl cis-trans isomerase and binds rapamycin.; Title: strong similarity to peptidyl-prolyl isomerase Fpr1 - Saccharomyces cerevisiae; See PMID 8674674; See PMID 9315655; See PMID 9371805
An14g00860	Catalytic activity: diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate.; Function: the LIP5 gene product from Candida rugosa hydrolyzes triacylglycerols into fatty acids and glycerol.; Title: strong similarity to triacylglycerol lipase Lip5 - Candida rugosa; See PMID 10473391
An14g00870	Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans
An14g00880	Function: the S. cerevisiae MSP1 protein is involved in mitochondrial membrane protein sorting.; Localization: the S. cerevisiae MSP1 protein belongs to the mitochondrial outer membrane.; Title: strong similarity to intra-mitochondrial sorting protein Msp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8226973
An14g00890	Title: similarity to nucleolar phosphoprotein p130 -Homo sapiens; nucleus; See PMID 7657714
An14g00900	Function: Mcd4 is involved in cell wall integrity in yeast.; Function: the S. cerevisiae MCD4 encodes a conserved component of the GPI anchor synthesis pathway.; Localization: protein seems to be localized as well in the ER as in the vacuole.; Title: strong similarity to glycosylphosphatidylinositol anchor synthesis protein Mcd4 - Saccharomyces cerevisiae; vacuole; See PMID 10069808; See PMID 10514566
An14g00920	Remark: disruption of cutinase gene in Fusarium solani pisi drastically decreased its virulence.; Remark: the ORF encoded transcription factor belongs to the fungal Cys6Zn2 binuclear cluster family.; Title: strong similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; nucleus; See PMID 7753774; See PMID 9139694
An14g00930	Catalytic activity: Cystathionine + H(2)O <=> L-homocysteine + NH(3) + pyruvate.; Cofactor: pyridoxal-phosphate.; Pathway: the cystathionine beta-lyase MetG from Emericella nidulans is involved in the methionine, cysteine, selenoamino acid, nitrogen, and sulfur metabolism.; Title: strong similarity to cystathionine beta-lyase metG - Aspergillus nidulans; See PMID 10467009; See PMID 2653822
An14g00940	Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe
An14g00950	EC:1.6.99.-.; Function: the Fre2 protein of S. cerevisiae is involved in iron uptake.; Induction: the expression of the FRE2 gene in S. cerevisiae becomes induced by iron-deprivation.; Remark: ORF may be a pseudogene, the database proteins are all longer at the N-terminus.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; See PMID 8164662; See PMID 8861201; See PMID 11120744
An14g00960	Catalytic activity: O3-acetyl-L-serine+H(2)S<=>L-cysteine+acetate.; Cofactor: pyridoxal-phosphate.; Pathway: the last enzymatic step for L-cysteine biosynthesis is catalyzed by the cysteine synthase B from Spinacia oleracea.; Title: similarity to chloroplast cysteine synthase B precursor cysk - Spinacia oleracea; See PMID 8405359; See PMID 1375015
An14g00970	Induction: the S. pombe fnx1 gene expression is induced during starvation.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An14g00980	Remark: N-terminally no significant similarities to database proteins.; Title: similarity to protein TRIAD3 - Homo sapiens; See PMID 10422847
An14g00990	Catalytic activity: 3-hydroxyacyl-CoA dehydrogenase: (S)-3-hydroxyacyl-CoA+NAD(+)<=>3-oxoacyl-CoA+NADH; Catalytic activity: enoyl-CoA hydratase: (3S)-3-hydroxyacyl-CoA<=>trans-2(or 3)-enoyl-CoA+H(2)O; Pathway: the trifunctional protein fox-2 from N. crassa is involved in the beta-oxidation of fatty acids.; Remark: the fox-2 protein from N. crassa carries three enzyme activities: 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxyacyl-CoA epimerase; enoyl-CoA hydratase.; Title: strong similarity to trifunctional protein of the beta-oxidation fox-2 - Neurospora crassa; See PMID 1830049; See PMID 7715608
An14g01000	Title: strong similarity to hypothetical protein CAB52731.1 - Schizosaccharomyces pombe
An14g01010	Complex: the YGL076c gene product from S. cerevisiae is part of cytoplasmic ribosomal large subunit.; Remark: alternate gene-names are RPL6A, YL8A,YGL076c.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L7 - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921; See PMID 1549461
An14g01020	Function: the ELL complex in human is involved in the derepression of gene expression.; Similarity: the human gene shows also sequence similarity to the S. cerevisiae SNF8.; Title: strong similarity to derepression ELL complex subunit EAP30 - Homo sapiens; See PMID 10419521
An14g01030	Function: the human eIF3-SU8 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA.; Remark: N-terminally truncated protein due to the end of contig.; Title: strong similarity to translation initiation factor eIF-3 subunit - Homo sapiens [truncated ORF]; cytoplasm; See PMID 8995409
An14g01040	Function: Nip1p has a primary role in translation initiation. Nip1p is a subunit of eukaryotic initiation factor 3 required for efficient translation initiation.; Localization: mainly cytoplasmic.; Remark: C-terminus truncated due to end of contig.; Title: similarity to nuclear transport protein Nip1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9722586; See PMID 1332047
An14g01050	Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein; Function: Yak1p functions as a negative regulator of the cell cycle in S. cerevisiae.; Remark: Yak1 acts downstream of the cAMP-dependent protein kinase in yeast.; Remark: the database proteins are all shorter in length.; Title: similarity to serine/threonine protein kinase Yak1 - Saccharomyces cerevisiae; See PMID 8150276; See PMID 10816418; See PMID 2558053
An14g01060	Complex: protein may interact with TFIIH, which is involved in transcription-coupled repair.; Function: putative helicase, DNA repair and recombination protein.; Similarity: also similarity to human DNA repair helicase ERCC6.; Title: strong similarity to DNA repair and recombination protein Rad26 - Saccharomyces cerevisiae; nucleus; See PMID 9566886; See PMID 9880486; See PMID 10666451
An14g01068	Title: strong similarity to EST an_2307 -Aspergillus niger
An14g01070	Remark: similarity corresponds only to multiple A and T-repeats.; Title: strong similarity to hypothetical protein EAA61306.1 - Aspergillus nidulans
An14g01080	Remark: similarities correspond to different short domains.
An14g01110	Function: YlALK1 functions to assimilate n-decane and longer molecules in Yarrowia lipolytica.; Induction: the expression of the P450 gene YlALK1 was induced by n-tetradecane and repressed by glycerol in Yarrowia lipolytica.; Remark: disruption of Yarrowia lipolytica gene ALK1 results in decreased n-decane assimilation.; Title: strong similarity to alkane-inducible cytochrome P450 gene ALK1 - Yarrowia lipolytica; See PMID 3892551; See PMID 9848230; See PMID 10953079
An14g01120	Similarity: the human gene has sequence homology with lysosomal prolylcarboxypeptidase.; Title: strong similarity to thymus specific serine peptidase TSSP - Homo sapiens; See PMID 10527559; See PMID 10630289
An14g01130	Expression: expression of rhamnogalacturonan degrading enzymes by A. acculeatus is regulated at the level of transcription and is subjected to carbon catabolite repression by glucose.; Function: the enzyme is found to be a rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-->4)-alpha-D-galactopyranosylur onide lyase.; Remark: rhamnogalacturonan is a pectic polysaccharide.; Title: strong similarity to rhamnogalacturonase B precursor rhgB - Aspergillus aculeatus; See PMID 7576553; See PMID 7592973; See PMID 7961884; See PMID 8587995
An14g01140	Catalytic activity: guanine + H2O = xanthine + NH3.; Remark: a putative sequencing error results in an frameshift.; Similarity: shows also similarity to chlorohydrolases from different bacteria.; Title: strong similarity to guanine deaminase Gda -Mus musculus [putative frameshift]; putative frameshift; See PMID 6098039; See PMID 8226898; See PMID 10075721
An14g01150	Catalytic activity: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.; Remark: protein is a component, with EC 2. 1. 2. 10,of the glycine cleavage system, previously known as glycine synthase.; Similarity: the protein shows also similarities to aminomethyltransferases from different organisms.; Title: strong similarity to glycine dehydrogenase component P - Pisum sativum; localisation:mitochondrion; See PMID 8206222; See PMID 9479445
An14g01160	Expression: DAL5 is a constitutively expressed allantoin system gene whose product is required for allantoate transport in yeast.; Remark: dal5 mutants of S. cerevisiae lack allantoate transport; these mutant strains also exhibit a 60% loss of allantoin transport capability.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3549700; See PMID 2651902; See PMID 3275614
An14g01170	Title: similarity to hypothetical protein B7F18.110 - Neurospora crassa
An14g01180	Remark: similarity corresponds to a distinct region.; Title: similarity to hypothetical protein encoded by An02g08790 - Aspergillus niger
An14g01190	Catalytic activity: L-arginine + H(2)O = L-ornithine + urea.; Regulation: arginase activity is regulated by various small molecules, including the product L-ornithine.; Remark: enzyme is a hexamer in B. caldovelox.; Title: similarity to arginase - Bacillus caldovelox; See PMID 8647285; See PMID 2029528
An14g01200	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 347305; See PMID 1990284
An14g01210	Function: protein oxidatively degrade glycated low molecular weight amines and amino acids under formation of hydrogen peroxide and glucosone in Aspergillus.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus; See PMID 9013588; See PMID 9139700
An14g01225	Function: SRPK2 phosphorylates the SR family of splicing factors in human.; Function: play an important role in regulating both the spliceosome assembly and their intranuclear distribution; Remark: ORF is truncated due to the border of contig.; Title: similarity to serine kinase SRPK2 - Homo sapiens [truncated ORF]; See PMID 10049757; See PMID 9472028
An14g01235	Title: strong similarity to essential gene #5905 from patent WO200277183-A2 - Bacteroides fragilis
An14g01245	Function: ord1 of A. flavus encodes a cytochrome P-450-type monooxygenase involved in conversion of O-methylsterigmatocystin to aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099
An14g01253	Remark: mutants defective in esterase RAG-1 lose to grow on simple triglycerides such as triacetin.; Title: similarity to esterase est - Acinetobacter calcoaceticus
An14g01255	Function: CTF1 beta from F. solani is involved in the constitutive expression of cut2 that causes production of low levels of cutin monomers that strongly induce cut1 using CTF1 alpha as the transcription factor.; Function: CTF1beta from F. solani regulates the gene induction by cutin monomers.; Title: similarity to cutinase transcription factor beta CTF1b - Fusarium solani; nucleus; See PMID 11756444; See PMID 8132657
An14g01260	Function: hapE of P. fluorescens catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate.; Similarity: the predicted ORF shows moderate similarity to several hypothetical and known monooxygenases with different specificity.; Title: similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873
An14g01270	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: FabG of S. melioti is the 3-oxoacyl-acyl carrier protein reductase that catalyzes the first reduction step in each cycle of fatty acid elongation.; Similarity: the predicted ORF shows similarity also to other oxidoreductases with different substrate specificity.; Title: similarity to 3-oxoacyl-(acyl carrier protein) reductase fabG - Sinorhizobium meliloti; See PMID 11277432
An14g01280	Similarity: the predicted protein shows similarity to many hypothetical short-chain dehydrogenases of various substrate specificities.; Title: similarity to hypothetical oxidoreductase SMa2343 - Sinorhizobium meliloti
An14g01310	Title: weak similarity to hypothetical protein PA3829 - Pseudomonas aeruginosa
An14g01330	Title: strong similarity to hypothetical protein encoded by An02g11890 - Aspergillus niger
An14g01340	Catalytic activity: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate.; Function: PcaB confers the ability to use 4-hydroxybenzoate or protocatechuate as the only carbon source. Hydroxyaromatics catabolism by pcaB serves both nutritional and detoxifying purposes.; Title: strong similarity to 3-carboxy-cis,cis-muconate cycloisomerase pcaB - Bradyrhizobium japonicum; See PMID 9582432
An14g01350	Function: the function of AmMST1 of A. muscaria as monosaccharide transporter was confirmed by heterologous expression of the cDNA in a S. pombe mutant lacking a monosaccharide uptake system.; Similarity: the predicted protein shows similarity to many hypothetical and known sugar transposters with different specificity.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An14g01360	Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Function: facB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 10483720; See PMID 9197408; See PMID 9524126
An14g01380	Similarity: the predicted protein shows weak similarity also to a synthetic patented subtilisin.; Title: weak similarity to intracellular alkaline serine proteinase - Thermoactinomyces sp.; See PMID 9058969
An14g01390	Title: strong similarity to hypothetical protein AAO75370.1 - Bacteroides thetaiotaomicron
An14g01400	Title: questionable ORF
An14g01410	Title: weak similarity to hypothetical galactose-1-phosphate uridylyltransferase galT -Pasteurella multocida
An14g01420	Title: strong similarity to hypothetical membrane protein YMR221c - Saccharomyces cerevisiae
An14g01430	Remark: C-terminally truncated ORF due to contig border.; Similarity: the similarity to PA2682 of P. aeruginosa involves only the C-terminal half of the two proteins.; Title: strong similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa [truncated ORF]
An14g01440	Catalytic activity: SSADH of R. norvegicus catalyzes the reaction: Succinate semialdehyde + NAD+ + H2O = Succinate + NADH.; Pathway: SSADH of R. norvegicus and other species is involved in the butanoate metabolic pathway, and in the glutamate catabolic pathway.; Phenotype: mutations in the SSADH gene in humans cause a neurological syndrome, due to a defect of catabolism of the neurotransmitter GABA.; Similarity: the predicted ORF shows strong similarity to different dehydrogenases, in particular to succinate-semialdehyde dehydrogenase; most of them are hypothetical and belong to different bacterial species, the first described one being the R. norvegicus enzyme.; Title: strong similarity to succinate-semialdehyde dehydrogenase SSADH - Rattus norvegicus; See PMID 7814412
An14g01450	Similarity: SPAC13C5. 04 of S. pombe and the predicted ORF show some similarity to tdnT of Pseudomonas putida, a hypothetical ORF of the aromatic amine catabolic pathway gene cluster, containing domains that are conserved among amidotransferases.; Title: strong similarity to hypothetical protein SPAC13C5.04 - Schizosaccharomyces pombe; See PMID 8990291
An14g01460	Catalytic activity: ATP + L-glutamate + NH3 <-> ADP + phosphate + L-glutamine.; Remark: glutamate--ammonia ligase is also known as glutamine synthetase.; Remark: manual closest BLASTP homologue: PIR:JC1301.; Title: strong similarity to glutamate--ammonia ligase III glnT - Rhizobium leguminosarum; See PMID 1356885
An14g01470	Title: strong similarity to hypothetical protein SPAC1039.06 - Schizosaccharomyces pombe
An14g01480	Function: levodione reductase in C. aquaticum catalyzes regio- and stereoselective reduction of levodione ((6R)-2,2,6-Trimethyl-1,4-cyclohexanedione) to (4R,6R)-4-hydroxy-2,2, 6-trimethylcyclohexanone (actinol).; Similarity: the predicted ORF shows similarity to many short-chain dehydrogenases with different substrate specificity.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066; See PMID 11388460
An14g01490	Remark: UME6 of S. cerevisiae is also called CAR80,NIM2, RIM16 or YDR207C.; Similarity: the similarity to UME6 of S. cerevisiae and other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: weak similarity to transcription factor Ume6 - Saccharomyces cerevisiae; See PMID 1579492
An14g01500	Title: strong similarity to hypothetical protein SPAC1039.06 - Schizosaccharomyces pombe
An14g01510	Similarity: the length of the predicted protein does not correspond to the one of N. crassa B24P7. 50.; Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa
An14g01520	Title: similarity to hypothetical protein encoded by An12g09920 - Aspergillus niger
An14g01530	Function: in B. polymyxa isp is involved in the generation of multiple beta-amylases and an alpha-amylase from a large amylase precursor.; Similarity: the C- terminal part of the predicted protein shows similarity to several other serine proteases like subtilisin.; Similarity: the similarity to isp of B. polymyxa is limited to the C-terminal third of the predicted protein.; Title: similarity to intracellular serine proteinase isp - Bacillus polymyxa; See PMID 1834632
An14g01540	Function: in spite of this similarity, TAT1 protein exhibit Na+-independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine, and this activity is not coupled with H+ transport, rather it behaves as an electroneutral facilitated diffusion.; Remark: a putative sequencing error results in an frameshift.; Similarity: the predicted protein and TAT1 of R. norvegicus show similarity to H+/monocarboxylate transporters.; Similarity: the predicted protein shows similarity to transporters with different specificity, thus the substrate is only hypothetical.; Title: similarity to aromatic amino acid transporter TAT1 - Rattus norvegicus [putative frameshift]; plasma membrane; putative frameshift; See PMID 11278508
An14g01550	Catalytic activity: acid phosphatases also catalyze transphosphorylations.; Catalytic activity: acid phosphatases catalyze the hydrolysis of an ortophosphoric monoester to alcohol + ortophosphate, with wide specificity.; Title: strong similarity to acid phosphatase AFPhoA - Aspergillus ficuum; extracellular/secretion proteins; See PMID 7945393
An14g01560	Complex: zuotin of S. cerevisiae is a component of the RAC (ribosome-associated complex), that is bound to the ribosome via the zuotin subunit.; Function: RAC stimulates the translocation of a ribosome-bound mitochondrial precursor protein into mitochondria, providing evidence for its chaperone-like effect on nascent chains.; Similarity: zuotin of S. cerevisiae and the predicted protein show strong similarity and functional homology to DnaJ/Hsp40, a molecular chaperone that,together with Hsp70, is involved in folding and translocation in various subcellular compartments of the newly synthesized proteins.; Title: strong similarity to zuotin Zuo1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9707440; See PMID 10660055; See PMID 11054575; See PMID 11274393; See PMID 1396572
An14g01570	Similarity: homologs of the present and the two previous ORFs are present in N. crassa in the same order.; Title: strong similarity to hypothetical protein B24P7.260 - Neurospora crassa
An14g01580	Complex: SPCC550. 02c of S. pombe, also called cwf5p, coimmunoprecipitates with a 40S protein complex involved in pre-mRNA splicing.; Similarity: homologs of the previous, present and next ORF are present in N. crassa in the same order.; Similarity: the predicted protein is very similar to the hypotetical protein B24P7. 250 of N. crassa.; Title: strong similarity to hypothetical RNA binding protein SPCC550.02c - Schizosaccharomyces pombe; See PMID 10409726
An14g01590	Catalytic activity: ERG6 of C. albicans converts S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol to S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.; Complex: ERG6 of C. albicans is a homotetramer.; Pathway: ERG6 of C. albicans carries out methylation of zymosterol as part of the ergosterol biosynthesis pathway.; Similarity: homologs of the present and the two next ORFs are present in N. crassa in the same order.; Title: strong similarity to sterol transmethylase ERG6 - Candida albicans; See PMID 9593144
An14g01600	Induction: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; See PMID 10978525
An14g01610	Title: similarity to hypothetical protein BAC75132.1 - Streptomyces avermitilis
An14g01620	Title: weak similarity to heparanase - Homo sapiens; See PMID 10764835
An14g01630	Phenotype: overexpression of SNG1 in S. cerevisiae confers hyper-resistance to the mutagen N-methyl-N'nitro-N-nitrosoguanidine (MNNG), whereas null mutants are viable and exhibit only slight sensitivity to MNNG, indicating that SNG1 does not encode a protein involved in a major detoxification step of this mutagen.; Similarity: the predicted protein is about 100 residues shorter than SNG1 of S. cerevisiae.; Title: similarity to nitrosoguanidine resistance factor Sng1 - Saccharomyces cerevisiae; See PMID 7753113
An14g01660	Catalytic activity: in Brevibacterium sp. chnB2 catalyzes the oxidation of cyclohexanone.; Similarity: the predicted ORF shows strong similarity to many known and putative flavin-binding monooxygenases with different substrate specificity.; Similarity: the predicted protein shows very strong similarity to a flavin monooxygenase involved in the degradation of fumonisin in Exophiala spinifera, patented under number WO200105980-A1.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp.; See PMID 10894733
An14g01670	Function: PRF from N. haematococca binds at a promoter-distal element which provided transcriptional activation.; Similarity: the similarity to other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: similarity to binuclear zinc transcription factor PRF - Nectria haematococca; See PMID 8850087; See PMID 856968
An14g01680	Function: MCT3 of R. norvegicus is necessary for efflux of lactic acid from several cell types, but mostly from muscle fibers.; Similarity: the predicted protein shows similarity to many hypothetical membrane proteins and particularly to monocarboxilate transporters.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638
An14g01700	Function: PHO84 of S. cerevisiae catalyzes a proton-coupled phosphate transport at acidic pH.; Function: in S. cerevisiae another phosphate transport appears to be due to a constitutive low-affinity H+-phosphate symporter and a high-affinity Na+-phosphate co-transporter.; Induction: PHO84 of S. cerevisiae is derepressed in low phosphate.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to high-affinity inorganic phosphate/H+ symporter Pho84 - Saccharomyces cerevisiae [putative frameshift]; plasma membrane; putative frameshift; See PMID 2038328; See PMID 8552045; See PMID 8720066; See PMID 1398064; See PMID 1620108
An14g01710	Function: NapA of E. hirae, together with an ATP-driven sodium pump, contributes to Na+ extrusion when the bacterium grows in a sodium-rich environment.; Similarity: the predicted protein shows moderate similarity to several putative Na+/H+ antiporters; NapA of E. hirae is only the better described one.; Title: similarity to Na+/H+-exchanging protein NapA - Enterococcus hirae; plasma membrane; See PMID 8253756; See PMID 1312090; See PMID 1325937
An14g01720	Similarity: shows homology to fibroin repeat domains.
An14g01730	Function: DEAD-box helicases are involved in various aspects of RNA transcription, processing and degradation.; Function: DEAD-box helicases require ATP for the unwinding of nucleic acids.; Similarity: belongs to the family of DEAD/DEAH box helicases.; Title: strong similarity to hypothetical DEAD/DEAH-box RNA helicase SPAC694.02 - Schizosaccharomyces pombe
An14g01750	Function: OXRD-4 of H. sapiens contains a nitrogenase Mo/Fe metalloprotein domain.; Function: OXRD-4 of H. sapiens is thought to be involved in cell proliferation and inflammation.; Similarity: contains a Rieske [2Fe-2S] iron-sulfur metalloprotein domain.; Similarity: shows homology to a protein of the patent database entry PATENTPROT:AAB19929.; Title: similarity to oxidoreductase OXRD-4 from patent WO200071679-A2 - Homo sapiens
An14g01760	Remark: EC 2. 3. 1. 41 in eukaryotes normally is part of the multifunctional fatty acid synthase protein.; Remark: it cannot be ruled out that this ORF and the upstream ORF An14g01750 (coding for a putative oxidoreductase) actually constitute a single ORF as predicted by fgenesh.; Title: strong similarity to hypothetical 3-oxoacyl-(acyl-carrier-protein) synthase T32M21.120 -Arabidopsis thaliana
An14g01770	Catalytic activity: bgln of C. molischiana catalizes the hydrolysis of terminal non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: bgln of C. molischiana is mainly involved in the degradation of various aromatic beta-glycosides, eg anthocyanin.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245
An14g01800	Catalytic activity: melibiose + H2O = galactose + glucose.; Title: strong similarity to alpha-galactosidase -Cyamopsis tetragonoloba; See PMID 2577496
An14g01810	Function: VanD of E. faecium confers resistance to glycopeptides which would bind to D-alanyl-D-alanine-terminating peptidoglycan precursors,thus preventing their incorporation into the cell wall.; Function: VanD of E. faecium is involved in the biosynthesis of D-alanyl-D-lactate-terminating peptidoglycan precursors.; Similarity: belongs to the family of D-alanine:D-alanine ligases.; Title: similarity to D-alanine:D-lactate ligase vanD - Enterococcus faecium; See PMID 10368136
An14g01820	Title: strong similarity to hypothetical cell wall protein binB - Aspergillus nidulans; See PMID 10376827
An14g01840	Remark: the systematic gene name of TIR3 of S. cerevisiae is YIL011w.; Similarity: TIR3 of S. cerevisiae is related to the temperature-shock induced protein TIP1 of S. cerevisiae.; Title: similarity to hypothetical temperature-shock induced protein Tir3 - Saccharomyces cerevisiae
An14g01850	Function: UGA4 of S. cerevisiae mediates the cellular uptake of gamma-aminobutyric acid (GABA).; Induction: UGA4 of S. cerevisiae is induced at the transcriptional level in the presence of GABA, requiring the the inducer-specific factor UGA3 and the pleiotropic factor UGA35/DURL/DAL81.; Repression: UGA4 of S. cerevisiae is repressed by the pleiotropic UGA43/DAL80 repressor.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; plasma membrane; See PMID 8455553
An14g01860	Function: RIM2 of S. cerevisiae is essential for mitochondrial DNA metabolism.; Phenotype: inactivation of RIM2 of S. cerevisiae causes the total loss of mitochondrial DNA.; Similarity: belongs to the mitochondrial carrier family (MCF).; Title: strong similarity to mitochondrial carrier protein Rim2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7891656
An14g01870	Similarity: contains a ATP binding domain reminiscent of AAA family ATPases.; Title: similarity to hypothetical ATPase SCD8A.32c -Streptomyces coelicolor
An14g01880	Catalytic activity: phosphatidyl-L-serine = phosphatidylethanolamine + CO2.; Pathway: PSD2 of S. cerevisiae is involved in the biosynthesis of phasphatidylethanolamine.; Title: similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740
An14g01890	Title: questionable ORF
An14g01900	Remark: ORF truncated C-terminally due to end of contig.; Title: weak similarity to hypothetical protein encoded by An09g04780 - Aspergillus niger [truncated ORF]
An14g01910	Function: lovB of A. terreus interacts with lovC in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Pathway: lovB of A. terreus is involved in the lovastatin biosynthesis.; Phenotype: disruption of the lovB gene of A. terreus results in a mutant that is unable to synthesize the nonaketide portion of lovastatin.; Remark: lovastatin is an HMG-CoA reductase ((3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase) inhibitor and thus acting as a cholesterin lowering agent.; Remark: the ORF is C-terminally truncated due to the contig border, however nearly the complete amino acid sequence of lovB of A. terreus is encompassed in the alignment with the ORF.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [truncated ORF]; See PMID 11378962; See PMID 10381407
An14g01920	Remark: unusual intron/exon structure for A. niger and short length (49 amino acids).; Title: questionable ORF
An14g01930	Remark: unusual intron/exon structure for A. niger and short length (39 amino acids).; Title: questionable ORF
An14g01940	Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: lovastatin is an HMG-CoA reductase ((3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase) inhibitor and thus acting as a cholesterin lowering agent.; Similarity: lovC of A. terreus belongs to the Zn-containing oxidoreductases family.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 11386351; See PMID 11412974
An14g01950	Function: the SPAC18B11. 03c gene product of S. pombe is described as a potential integral membrane protein; however no transmembrane domains have been predicted in the ORF.; Title: similarity to hypothetical protein SPAC18B11.03c - Schizosaccharomyces pombe
An14g01960	Function: Axs of D. melanogaster is not required for the segregation of achiasmate heterologs.; Function: Axs of D. melanogaster is required for the meiotic segregation of achiasmate homologs.; Similarity: the alignment between Axs of D. melanogaster and the ORF encompasses only amino acids 146-587 of the ORF (total ORF length: 734 amino acids).; Title: strong similarity to aberrant X segregation Axs - Drosophila melanogaster; See PMID 2503421; See PMID 8349113
An14g01970	Function: aflR of A. parasiticus is a transcription factor, activating the transcription of all known aflatoxin biosynthetic genes including itself.; Function: aflR of A. parasiticus is essential for aflatoxin biosynthesis.; Similarity: the ORF shows strong local similarity to aflR genes of different Aspergillus species. The alignments encompass only ca. 100 amino acids, but the zinc finger DNA binding domain is always included.; Title: similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus; See PMID 10919326; See PMID 10967969; See PMID 11414325
An14g01980	Catalytic activity: menG of B. stearothermophilus catalyzes the transfer of a methyl group from 2-heptaprenyl to 1,4-naphthoquinone.; Function: menG of B. stearothermophilus catalyzes the last step of the menaquinone biosynthesis.; Pathway: menG of B. stearothermophilus participates in menaquinone (vitamin K2) biosynthesis.; Remark: menG of B. stearothermophilus belongs to the UBIE family.; Similarity: the ORF is shows similarity (the alignments are all also partial) with methyltransferase of various species.; Similarity: the ORF shows strong similarity to the hypothetical protein SC1E6. 19c of Streptomyces coelicolor.; Similarity: the alignment of the ORF with menG of B. stearothermophilus encompasses only amino acids 39-147 of the ORF (total length: 266 amino acids).; Title: similarity to 2-heptaprenyl-1,4-naphthoquinone methyltransferase menG - Bacillus stearothermophilus; See PMID 9139683
An14g01990	Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF overlaps C-terminally with the A. niger EST an_3143, found in EMBLEST:BE758887.; Similarity: the ORF shows unspecific similarity to the protein of gene CG6590 of D. melanogaster and to other proteins, due to it's high proline content.; Title: strong similarity to EST an_3143 -Aspergillus niger
An14g02010	Function: the Hum1 protein of S. cerevisiae has been postulated to be involved in cellular adaption to elevated extracellular Ca2+ concentrations and to be a means to attenuate the propagation of Ca2+ signals in this organism.; Function: the Hum1 protein of S. cerevisiae is required for vacuolar Ca2+/H+ exchange.; Function: vacuolar membrane vesicles from hum1 S. cerevisiae mutants lack all Ca2+/H+ antiport activity,demonstrating that the Hum1 protein catalyzes the exchange of Ca2+ for H+ across the yeast vacuolar membrane.; Remark: Hum1 of S. cerevisiae is also called mnr1,vcx1, and YDL128w.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8668190; See PMID 10219995; See PMID 10371152
An14g02020	Remark: the ORF has an unusual exon/intron structure for A. niger.
An14g02030	Similarity: the ORF shows local similarity to SPAC57A7. 05 of S. pombe: the two proteins are similar to each other along a stretch of about 350 amino acids in length.; Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe
An14g02040	Remark: contig An14c0100 contains a C-terminally truncated ORF with similarity to the N-terminal region of A. oryzae mreA, indicating that a gap of ~1000 bp with the central region of a predicted isoamyl alcohol oxidase is between contig An14c0090 and An14c0100.; Remark: the ORF is N-terminally truncated due to the contig border.; Similarity: the ORF shows local similarity along a stretch of more than 100 amino acids to mreA of A. oryzae; the local similarity is restricted to the C-terminus of the ORF.; Title: similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae [truncated ORF]
An14g02050	Remark: contig An14c0100 contains a N-terminally truncated ORF with similarity to the C-terminal region of A. oryzae mreA, indicating that a gap of ~1000 bp with the central region of a predicted isoamyl alcohol oxidase is between contig An14c0090 and An14c0100.; Remark: the ORF is C-terminally truncated due to contig border.; Similarity: similarity is between the predicted A. niger protein and the N-terminal region of A. oryzae mreA.; Title: similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae [truncated ORF]
An14g02060	Catalytic activity: trans,trans-farnesyl diphosphate <=> aristolochene + diphosphate; Function: Ari1 of P. roqueforti synthesizes aristolochene.; Pathway: Ari1 of P. roqueforti is a component of the sesquiterpenoid biosynthetic pathway.; Remark: Ari1 of P. roqueforti is a member of the terpene cyclase group of enzymes.; Remark: aristolochene is the likely precursor of the sesquiterpenoid PR-toxin, produced by Penicillium roqueforti.; Remark: the Ari1 gene of P. roqueforti encodes the sesquiterpene cyclase, also called aristolochene synthase.; Similarity: more than 100 c-terminal amino acids of the ORF are not included in the alignment with Ari1 of P. roqueforti.; Title: similarity to aristolochene synthase Ari1 -Penicillium roqueforti; See PMID 8440737
An14g02070	Similarity: the ORF has a local similarity to celE of C. thermocellum encompassing ca. 250 C-terminal amino acids.; Title: weak similarity to endo-1,4-beta-glucanase celE - Clostridium thermocellum; See PMID 3066698
An14g02080	Catalytic activity: prolidase of A. esteraromaticum hydrolysis Xaa-|-Pro dipeptides.; Remark: a substrate for prolidase of A. esteraromaticum is Pro-Hyp.; Similarity: 100 N-terminal amino acids of the ORF are not aligned with prolidase of A. esteraromaticum.; Similarity: the ORF shows also strong similarity to (hypothetical) aryldialkylphosphatases.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239
An14g02100	Function: the MP1 protein of P. marneffei is a cell wall mannoprotein with high affinity for concanavalin A.; Localization: immunogold staining indicated that MP1 of P. marneffei is present in the cell walls, hyphae, and conidia.; Remark: the MP1 protein of P. marneffei acts as a immunogen: P. marneffei infected patients develop a specific antibody response against MP1.; Similarity: the MP1 protein of P. marneffei is 159 amino acids longer than the ORF; the complete ORF sequence is encompassed in the alignment between the two proteins.; Similarity: the ORF overlaps with the A. niger ESTs an_3233 in EMBLEST:BE758971, an_3139 in EMBLEST:BE758883, an_2550 in EMBLEST:BE759683, an_1941 in EMBLEST:BE760597,an_3048 in EMBLEST:BE758804, and an_2258 in EMBLEST:BE759444.; Title: strong similarity to cell wall antigen MP1 -Penicillium marneffei; cell wall; See PMID 9488383
An14g02110	Remark: the ORF has an unusual exon/intron structure for A. niger and is short in length.; Title: questionable ORF
An14g02120	Remark: the ORF has an unusual exon/intron structure for A. niger and is short in length.
An14g02130	Function: atpc-2 of A. thaliana binds to a promoter region located immediately upstream of the CAAT box of the spinach AtpC gene (encoding the gamma subunit of the ATP synthase) and thereby prevents CBF binding, thus repressing AtpC gene expression.; Remark: atpc-2 of A. thaliana has a modular structure.; Similarity: atpc-2 of A. thaliana shows homology to helicases.; Similarity: the ORF has local similarity with atpc-2 of A. thaliana: only the N-terminal half of the ORF is included in the alignment.; Similarity: the ORF shows strong similarity to patent WO0118208 in TREMBL:AX098230_1 and to other hypothetical proteins.; Title: similarity to transcription repressor protein AtPC-2 - Arabidopsis thaliana; See PMID 11274172
An14g02140	Remark: CDPK1 of M. polymorpha is alternatively spliced.; Title: weak similarity to Ca-dependent protein kinase CDPK1 - Marchantia polymorpha; See PMID 10202816
An14g02150	Function: cpdS of A. phoenicis removes acidic,neutral and basic amino acids as well as proline from the C-terminal position at pH 2-5.; Remark: A. phoenicis is also called A. saitoi.; Remark: cpdS of A. phoenicis has a catalytic triad comprising Asp-His-Ser.; Remark: cpdS of A. phoenicis is a member of serine carboxypeptidase family .; Similarity: the ORF shows also strong similarity to serine-type carboxypeptidase of A. niger.; Title: strong similarity to serine-type carboxypeptidase precursor cpdS - Aspergillus phoenicis; See PMID 7772020
An14g02160	Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Function: adhA of S. meliloti reduces alcohols.; Remark: Rhizobium meliloti is also called Sinorhizobium meliloti.; Remark: adhA of S. meliloti belongs to the zinc-containing alcohol dehydrogenase family.; Title: strong similarity to alcohol dehydrogenase adhA - Sinorhizobium meliloti; See PMID 9659380
An14g02170	Catalytic activity: cut A of F. solani hydrolysis cutin, a polyester that forms the structure of plant cuticle.; Function: cutinases allow pathogenic fungi to penetrate through the cuticular barrier of the host plant during the initial phase of fungal infection.; Induction: cut A of F. solani is induced by cutin.; Remark: cut A of F. solani belongs to the cutinase family.; Title: strong similarity to cutinase precursor cutA - Fusarium solani; extracellular/secretion proteins; See PMID 10556791; See PMID 11099798
An14g02180	Catalytic activity: UDP-glucose + D-glucose 6-phosphate <=> UDP + alpha,alpha-trehalose 6-phosphate.; Induction: transcription of tpsB of A. niger was hardly detectable at ambient temperatures but was enhanced strongly upon heat shock, which agrees with the presence of several copies of a C4T stress-responsive element in its 5'-upstream sequences.; Remark: the ORF shows strong similarity to A. niger trehalose synthase of patent WO9824882-A1 in PATENTPROT:AAW49027.; Remark: tpsB of A. niger belongs to other fungal tps1.; Title: strong similarity to trehalose-6-phosphate synthase tpsB - Aspergillus niger; See PMID 9006911
An14g02190	Remark: the ORF shows local similarity to the hypothetical membrane protein YGL247w of S. cerevisiae: only 144 amino acids (about 1/3) of the ORF are included in the alignment.; Title: similarity to hypothetical membrane protein YGL247w - Saccharomyces cerevisiae
An14g02200	Remark: the ORF overlaps with the A. niger ESTs an_2365 in EMBLEST:BE759538 and an_1441 in EMBLEST:BE760308: the former is a nearly complete overlap of both the EST and the ORF, the latter overlap, however,is very short.; Title: strong similarity to EST an_2365 -Aspergillus niger
An14g02210	Remark: IgA-specific metalloendopeptidase (EC: 3. 4. 24. 13) of N. meningitidis acts on the hinge region of the heavy chains of human IgA immunoglobulin, cleaving exclusively Pro-|-Thr and Pro-|-Ser bonds.; Remark: the ORF shows weak local similarity (over a stretch of 82 amino acids) to SFAG 2 carboxypeptidase Y of A. niger patent WO9609397-A1 in PATENTPROT:AAR96738.; Similarity: the ORF shows local similarity to two IgA-specific metalloendopeptidases (NMA0905 and NMB0700) of N. meningitidis: the alignments encompass only 152 amino acids of the ORF.; Title: strong similarity to hypothetical protein SPCC1620.10 - Schizosaccharomyces pombe; See PMID 7783620
An14g02220	Remark: the ORF is short in length.
An14g02230	Function: dsk1 of S. pombe encodes a kinase, which auto-phosphorylates as well as phosphorylates myelin basic protein (MBP).; Function: dsk1 of S. pombe may serve as a cell cycle regulator in coordinating pre-mRNA splicing.; Localization: dsk1 of S. pombe locates in the cytoplasm in G2-arrested cells, in mitotically arrested cells, however, it resides in the nucleus.; Phenotype: the haploid gene disruptant of dsk1 of S. pombe is viable; high dosage of dsk1, however, strongly delays the G2/M progression.; Remark: dsk1 of S. pombe belongs to the ser/thr family of protein kinases.; Remark: in mitotically arrested cells compared to interphase-arrested cells dsk1 of S. pombe is higher phosphorylated, and has a higher kinase activity.; Title: strong similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317; See PMID 9488736; See PMID 10629038
An14g02240	Remark: the ORF overlaps C-terminally with the A. niger EST an_0349 in EMBLEST:BE760713.; Remark: the gene CG16717 of D. melanogaster is from genomic scaffold 142000013386050 section 17 of 54.; Similarity: the ORF shows also strong similarity to 239AB and 239FB of H. sapiens; these proteins are localized at a chromosomal region associated with WAGR (Wilms tumor,aniridia, genitourinary anomalies, and mental retardation).; Similarity: the ORF shows local strong similarity to the gene CG16717 of D. melanogaster: 100 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Title: strong similarity to hypothetical protein encoded by CG16717 - Drosophila melanogaster
An14g02250	Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Complex: L-lactate dehydrogenase of P. anomala is composed of a cytochrome b2 core complexed to flavodehydrogenase (a tetramer).; Function: L-lactate dehydrogenase of P. anomala is an electron transfer enzyme.; Pathway: L-lactate dehydrogenase of P. anomala takes part in the pyruvate metabolism.; Remark: L-lactate dehydrogenase (EC: 1. 1. 2. 3.) is also called (flavo)cytochrome b2.; Remark: Pichia anomala is also called Hansenula anomala.; Similarity: the ORF shows also strong similarity to glycolate oxidases of different species (EC 1. 1. 3. 15).; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala; localisation:mitochondrion; See PMID 8240249; See PMID 8589063; See PMID 8589064; See PMID 9230706
An14g02260	Remark: Rab proteins constitute a family of GTP-binding proteins that are located in distinct intracellular compartments and play a role in the regulation of vesicular trafficking.; Remark: Rab proteins contain four highly conserved peptide sequences involved in GTP binding and hydrolysis; Title: strong similarity to small GTPase Rab24 from patent CN1257926-A - Mus musculus
An14g02280	Remark: the patent protein entry Y35412 which also shows weak similarity was not found in patent database.; Title: similarity to hypothetical protein encoded by An02g01160 - Aspergillus niger
An14g02290	Induction: the mRNA for the alpha 1 isoform of the NKAA1 gene from R. norvegicus, is expressed in all fetal and adult rat tissues examined.; Remark: Hydrolysis of ATP is coupled with the exchange of Na(+) and K(+) ions, and is specifically inhibited by ouabain.; Remark: designated alpha-S form; thought to arise from alpha-1 chain by post-translational modification; Remark: the isoform diversity of the Na,K-ATPase alpha subunit may provide a biochemical basis for Na,K-ATPase functional diversity.; Title: strong similarity to Na+/K+-exchanging ATPase alpha-1 chain NKAA1 - Rattus norvegicus; plasma membrane; See PMID 2163680; See PMID 2822726
An14g02300	Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Remark: the patent does not provide information about the function of the protein.; Title: similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana
An14g02320	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens
An14g02340	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to nucleolar phosphoprotein -Xenopus laevis
An14g02350	Similarity: the ORF also shows strong similarity to the EST an_3030 from Aspergillus niger.; Title: weak similarity to protein belonging to the presenilin superfamily protein S182 - Mus musculus
An14g02360	Complex: the human U2 snRNP-specific protein A' (U2A') forms a ternary complex together with the U2B' protein and the hairpin-loop IV of U2 small nuclear RNA.; Function: the human U2 snRNP-specific protein A' is involved in splicing of mRNA.; Remark: the human U2 snRNP-specific protein A' does not contain segments homologous to the RNP consensus sequences RNP1 and RNP2 of several RNA-binding proteins.; Title: strong similarity to U2 snRNA-specific protein A - Homo sapiens; nucleus; See PMID 9716128; See PMID 2928112
An14g02370	Catalytic activity: NTP + H(2)O <=> NDP + phosphate.; Function: the apyrase Ynd1 from S. cerevisiae is required for golgi N- and O-glycosylation and cell wall integrity.; Golgi; Phenotype: S. cerevisiae ynd1 null mutants are defective in O- and N-linked glycosylation in the Golgi compartments.; Remark: synonyms for Ynd1 from S. cerevisiae are Yej5 and YER005w.; Title: strong similarity to nucleoside diphosphatase Ynd1 - Saccharomyces cerevisiae; See PMID 10409709
An14g02390	Function: Mep2 from S. cerevisiae is a transporter which uses ammonium as a nitrogen source.; Remark: Mep2 from S. cerevisiae is an ammonium sensor, generating a signal to regulate filamentous growth in response to ammonium starvation.; Remark: Mep2 from S. cerevisiae, a high affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium limitation.; Remark: the synonyms for Mep2 from S. cerevisiae are YNL142w, N1207 and N1820.; Similarity: Mep2 from S. cerevisiae belongs to the Amt1/nrgA/Mep family of ammonium transporters.; Title: strong similarity to ammonium transport protein Mep2 - Saccharomyces cerevisiae; plasma membrane; See PMID 9234685; See PMID 9482721; See PMID 11069679; See PMID 8062822
An14g02410	Title: similarity to hypothetical conserved protein encoded by 17E5.150 - Neurospora crassa
An14g02420	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An14g02430	Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Title: weak similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana
An14g02440	Similarity: the ORF shows similarity to the EST of patent WO200056762-A2 from Aspergillus niger.; Title: similarity to EST SEQ ID NO:4362 from patent WO200056762-A2 - Aspergillus niger
An14g02450	Induction: Aqy2-1 from S. cerevisiae was detected only during the exponential growth phase in rich medium containing glucose.; Localization: Aqy2-1 from S. cerevisiae is located on the endoplasmic reticulum as well as on the plasma membrane.; Remark: AQY2 is disrupted by a stop codon in most S. cerevisiae strains.; Remark: the synonym for Aqy2 from S. cerevisiae is YLL052c.; Similarity: Aqy2 from S. cerevisiae is a member of mip family of aquaglyceroporin transmembrane channels.; Title: strong similarity to aquaporin water channel protein Aqy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 11158584; See PMID 11168368
An14g02460	Cofactor: FAD and protoheme IX were bound as cofactors by fhp of A. eutrophus.; Function: isogenic Fhp-negative mutant did not accumulate nitrous oxide during denitrification with nitrite as electron acceptor.; Function: isogenic Fhp-negative mutants showed no significant delay in aerobic or anaerobic growth.; Remark: Ralstonia eutropha = Alcaligenes eutrophus.; Remark: fhp of A. eutrophus contains a phospholipid-binding site.; Title: strong similarity to flavohemoglobin Fhp -Alcaligenes eutrophus; See PMID 8125952; See PMID 10336624
An14g02470	Remark: the human PRO304 protein is one of a couple of secreted and transmembrane polypeptides which could be used for treatment of skin diseases.; Remark: the patent WO200104311-A1 does not provide additional functional information.; Similarity: the ORF also shows strong similarities to the sequence of patents US 5821104 and WO9614404-A1 and the EST an_3412 from Aspergillus niger.; Title: strong similarity to protein PRO304 from patent WO200104311-A1 - Homo sapiens
An14g02480	Title: weak similarity to catalase protein from patent CN1219588-A - Bacillus thermoglucosidasius
An14g02490	Title: weak similarity to protein from patent WO200056892-A1 - Streptomyces albulus
An14g02500	Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae
An14g02510	Title: weak similarity to hypothetical protein of the gtp1/obg family PAB0558 - Pyrococcus abyssi
An14g02520	Title: weak similarity to hypothetical protein T04D1.4 - Caenorhabditis elegans
An14g02530	Title: weak similarity to protein serine/threonine kinase-1 psk1 - Plasmodium falciparum
An14g02540	Title: weak similarity to sterol regulatory element-binding protein-1 SREBP-1 - Mus musculus
An14g02560	Title: similarity to protein from patent EP0845532 -Pseudomonas sp.
An14g02570	Title: similarity to EST Nig077 - Aspergillus niger
An14g02590	Function: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An14g02610	Localization: integral membrane protein.; Remark: cDNA of atrB can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; plasma membrane; See PMID 9180695
An14g02620	Title: similarity to hypothetical protein encoded by An13g01640 - Aspergillus niger
An14g02630	Similarity: short stretches of weak similarity are due to low complexity regions, and do not look significant.
An14g02640	Remark: the patent database entry represents one of the proteins encoded by all the open reading frames in the complete genome of Chlamydia pneumoniae.; Similarity: the predicted ORF indeed shows some structural motif in common with such enzymes, but the similarity is too weak to draw conclusions about the function.; Similarity: the predicted ORF shows also a much weaker similarity to several proteins defined as cobalamin-independent methionine synthase on the basis of the similarity to E. coli metE gene.; Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae
An14g02650	Catalytic activity: acid phosphatases also catalyze transphosphorylations.; Catalytic activity: acid phosphatases catalyze the hydrolysis of an ortophosphoric monoester to alcohol + ortophosphate, with wide specificity.; Remark: a putative sequencing error results in a frameshift.; Similarity: the predicted ORF also shows similarity to a phospholipase of Fusarium venenatum, patentnumber WO200041509-A2.; Similarity: the predicted ORF also shows similarity to a variety of hypothetical proteins annotated as survival factors, due to the similarity to E. coli SurE, a protein with unknown molecular function, but required for survival.; Title: similarity to acid phosphatase PHO2 -Yarrowia lipolytica [putative frameshift]; putative frameshift; See PMID 1423722; See PMID 7928962
An14g02660	Title: strong similarity to hypothetical necrosis and ethylene inducing protein BH0395 - Bacillus halodurans
An14g02670	Function: the predicted ORF shows strong similarity to many glycosidases involved in the catabolism of different polysaccharides.; Induction: T. reesei egl4 is regulated in the same manner as other cellulase genes of this fungus.; Title: strong similarity to endoglucanase IV egl4 -Trichoderma reesei; extracellular/secretion proteins; See PMID 9370370
An14g02680	Title: weak similarity to hypothetical xylosidase/arabinosidase - Streptomyces coelicolor
An14g02690	Title: weak similarity to hypothetical protein MT4026.1 - Mycobacterium tuberculosis
An14g02700	Function: itr2 of S. pombe is a transporter for myo-inositol.; Similarity: itr2 of S. pombe belongs to the sugar transporter family.; Similarity: the predicted ORF shows a much stronger similarity to a putative myo-inositol transporter of N. crassa.; Title: strong similarity to myo-inositol transporter 2 itr2p - Schizosaccharomyces pombe; plasma membrane; See PMID 9560432
An14g02710	Similarity: the predicted ORF shows a weak, but consistent similarity to different vertebrate inward rectifying potassium channels.; Title: weak similarity to inward rectifier potassium channel protein cIRK1 - Gallus gallus; See PMID 7642595
An14g02720	Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids.; Similarity: mtr of N. crassa belongs to the Amino Acid/Auxin Permease (AAAP) family.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 8001794; See PMID 1838345
An14g02730	Title: weak similarity to thioredoxin reductase tr/trx - Mycobacterium leprae; See PMID 7476189
An14g02740	Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An14g02750	Function: in spite of the strong similarity to ABC transporters, these proteins are located in the cytoplasm,where they associate with the ribosomal fraction; their are involved in the control of translation via direct or indirect regulation of elongation factor eIF2.; Similarity: the predicted ORF shows strong similarity to many members of the ABC transporter family; nevertheless, its closer homologues are GCN20 of S. cerevisiae and the mammalian counterparts ABC50 of H. sapiens and R. norvegicus.; Title: strong similarity to protein Gcn20 -Saccharomyces cerevisiae; cytoplasm; See PMID 9020838; See PMID 9234705; See PMID 9790762; See PMID 10931828; See PMID 7621831
An14g02760	Catalytic activity: endohydrolysis of 1,4-beta-d-glucosidic linkages in cellulose.; Function: eglA has carboxylmethylcellulase activity.; Gene-ID: eglA; Induction: transcription of eglA is induced by the transcription factor XlnR.; Remark: A. niger eglA has been patented under patentnumber WO9713853-A2.; Similarity: eglA belongs to cellulase family h (family 12 of glycosyl hydrolases).; See PMID 9758775
An14g02770	Title: weak similarity to hypothetical Stig1 -Petunia hybrida
An14g02780	Function: the UaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421
An14g02790	Title: weak similarity to hypothetical 2,3-cyclic-nucleotide 3-phosphodiesterase related protein -Neurospora crassa
An14g02830	Similarity: the predicted A. niger ORF shows similarity to several different dehydrogenases.; Title: weak similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042
An14g02840	Title: similarity to hypothetical protein EAA58614.1 - Aspergillus nidulans
An14g02850	Remark: blastp shows significant similarity (52% positives) between the predicted A. niger protein and R. erythropolis ORF4 but due to shortness of both peptides the calculated probability is low (p=0,002).; Title: similarity to hypothetical protein ORF4 -Rhodococcus erythropolis
An14g02860	Catalytic activity: Atrazine chlorohydrolases convert Atrazine + H(2)O to 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride.; Function: Pseudomonas AtzA catalyzes the dechlorination of atrazine, simazine, and desethylatrazine but is not active with melamine, terbutylazine, or desethyldesisopropylatrazine.; Remark: EC 3. 8. 1. 8; Title: strong similarity to atrazine chlorohydrolase atzA - Pseudomonas sp.; See PMID 8759853
An14g02870	Catalytic activity: Succinate-semialdehyde dehydrogenases convert Succinate semialdehyde + NAD(P)(+) + H(2)O to succinate + NAD(P)H.; Function: in E. coli gabD is required for the utilisation of 4-hydroxyphenylacetate as nitrogene source.; Function: in higher eucaryotes Succinate-semialdehyde dehydrogenases are required for the catabolism of GABA intermediates.; Function: mutations of Succinate-semialdehyde dehydrogenases in higher eucaryotes give rise to central nervous system dysfunction.; Title: strong similarity to succinate-semialdehyde dehydrogenase gabD - Escherichia coli; See PMID 2254272; See PMID 6756331; See PMID 8412016
An14g02880	Function: S. cerevisiae Mal31 is a high-affinity maltose transporter.; Title: strong similarity to maltose transport protein Mal31 - Saccharomyces cerevisiae; plasma membrane; See PMID 1999393; See PMID 2549370
An14g02890	Catalytic activity: S. scrofa LTB4/PGR converts (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)(+) to (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H.; Function: S. scrofa LTB4/PGR is required for the metabolism of the hormones prostaglandin and leukotrien.; Title: strong similarity to 5-oxoprostaglandin 13-reductase LTB4/PGR - Sus scrofa; See PMID 9461497; See PMID 8576264
An14g02900	Catalytic activity: Cellobiose dehydrogenases convert Cellobiose + acceptor to cellobiono-1,5-lactone + reduced acceptor.; Function: T. versicolor CDH is required for wood-degradation.; Similarity: T. versicolor CDH is a hemoflavoenzyme.; Title: weak similarity to cellobiose dehydrogenase CDH - Trametes versicolor; See PMID 9573367
An14g02910	Function: Dal5p of S. cerevisiae is a component of the allantoate transport system.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae [truncated ORF]; See PMID 3275614; See PMID 3294799; See PMID 3301804
An14g02920	Title: strong similarity to hypothetical conserved protein yesR - Bacillus subtilis
An14g02930	Title: similarity to hypothetical protein encoded by An12g07270 - Aspergillus niger
An14g02940	Function: L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans T-100 show an ability to convert D-sorbitol to 2-keto-L-gulonate (2-KLGA).; Function: chemical mutation of the host strain to suppress the L-idonate pathway and replacement of the original promoter with that of E. coli tufB resulted in improving the production of 2-KLGA.; Function: consequently, high-level production from D-sorbitol to 2-KLGA (130 mg/ml) was achieved by simple fermentation of the recombinant Gluconobacter.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase - Gluconobacter oxydans; See PMID 9023923; See PMID 10191408
An14g02950	Similarity: show strong similarity to several oxidoreductases of different organims.; Title: strong similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae
An14g02960	Title: similarity to hypothetical protein encoded by An01g14870 - Aspergillus niger
An14g02970	Similarity: shows strong similarity to sensory transduction histidine kinases and phytochrome-like proteins.; Title: similarity to phytochrome phy - Synechocystis sp.; See PMID 9487803
An14g02980	Similarity: similarity results from repetitive sequences.; Title: weak similarity to mucin-like glycoprotein 900 GP900 - Cryptosporidium parvum
An14g02990	Title: similarity to hypothetical protein KIAA1715 -Homo sapiens
An14g03000	Function: CAF of A. thaliana appears to suppress cell division in floral meristems.; Title: similarity to RNA helicase/RNAseIII carpel factory CAF - Arabidopsis thaliana; See PMID 10556049
An14g03010	Function: might be involved in transcriptional regulation.; Similarity: shows similarity to proteins containing bZIP transcription factor domains.; Title: weak similarity to transcription activator Cin5 - Saccharomyces cerevisiae
An14g03020	Function: suggested activities include nutritional activity, cytokine and cell proliferation/differentiation activity, immune stimulating (e. g. as vaccines) or suppressing activity, haematopoiesis regulating activity,tissue growth activity, activin/inhibin activity,chemotactic/chemokinetic activity, haemostatic and thrombolytic activity, receptor/ligand activity,anti-inflammatory activity, cadherin/tumour invasion suppressor activity, and tumour inhibition activity.; Function: the human secreted proteins, and the polynucleotides encoding them, are predicted to have biological activities which would make them suitable for treating, preventing or ameliorating medical conditions in humans and animals.; Remark: blast hit against protein of patent database.; Title: similarity to secreted protein SEQ ID NO:58 from patent WO9957132-A1 - Homo sapiens
An14g03030	Catalytic activity: it catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.; Function: human SPD/SPM acetyltransferase is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism.; Remark: contains putative sequencing error that caused a wrong geneprediction (wrong start codon).; Similarity: shows similarity to several acetyltransferases of different species.; Title: similarity to spermidine/spermine N(1)-acetyltransferase SAT - Homo sapiens [putative frameshift]; putative frameshift; See PMID 1985966
An14g03040	Similarity: shows similarity to myosin heavy chain of different species.; Title: similarity to myosin heavy chain -Dictyostelium discoideum; See PMID 2828113; See PMID 3540939; See PMID 3901008
An14g03050	Similarity: shows weak similarities to neuropathy target esterases.; Title: strong similarity to hypothetical protein of the UPF0028 family - Schizosaccharomyces pombe
An14g03060	Title: strong similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger
An14g03070	Catalytic activity: CHO has oligosaccharide oxidation activity.; Function: it can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e. g. preferentially oxidizing maltodextrins or cellodextrins over glucose.; Similarity: shows strong similarity to several oxidases with unknown function and to M. nivale carbohydrate oxidase (CHO) i. e. protein Y24919 of patent WO9931990-A1.; Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale
An14g03080	Localization: might be a transmembrane protein.; Similarity: seems to be the aminoterminus of the predicted protein.; Similarity: shows strong similarity to pos. 121 to 553 of cDNA clone 2960 of A. niger.; Similarity: the ORF shows strong similarity to cDNA clone 2960 - Aspergillus niger.; Title: similarity to hypothetical membrane protein YDL218w - Saccharomyces cerevisiae
An14g03090	Title: strong similarity to glucose/galactose transporter gluP - Brucella abortus; See PMID 9168605
An14g03100	Function: chicken enzyme is responsible for the formation of pentaantennary asparagine-linked oligosaccharides (N-glycans).; Similarity: shows only similarity to aminoterminal part of chicken enzyme and similiar enzymes of other species.; Title: weak similarity to N-acetylglucosaminyltransferase VI GnT-VI - Gallus gallus; See PMID 10962001
An14g03110	Function: initial oxygenation step in trichothecene toxin biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 7651333; See PMID 9529523
An14g03120	Similarity: shows only similarity to the central part of pth11.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea
An14g03140	Function: sporulation and tetrad analysis revealed that deletion of YNL059c/ARP5 was lethal for vegetative growth in strain W303 and caused severe growth defects in strain FY1679.; Title: strong similarity to nuclear protein YNL059c - Saccharomyces cerevisiae; nucleus; See PMID 10923024
An14g03160	Title: weak similarity to hypothetical protein CAE02259.1 - Oryza sativa
An14g03180	Function: Cdc3-profilin may play an essential role in cytokinesis by catalyzing the formation of the F-actin contractile ring.; Function: in S. pombe, cdc3-124 mutant is defective for cytokinesis, but not for DNA replication, mitosis, or septum synthesis.; Function: profilin is an actin-monomer-binding protein.; Title: strong similarity to profilin cdc3p -Schizosaccharomyces pombe; cytoskeleton
An14g03190	Remark: only repetitive elements are matching.; Title: weak similarity to hypothetical protein EG:56G7.1 - Drosophila melanogaster
An14g03200	Remark: the ORF is transcribed in vegetative cells but it is not essential for viability as demonstrated by gene disruption.; Similarity: homologous to RNA-helicase SKI2 S. cerevisiae.; Title: strong similarity to hypothetical RNA-helicase G9365 - Saccharomyces cerevisiae; See PMID 9133744
An14g03210	Remark: strong similarity to human transcriptional regulator protein #28 patent WO200078954-A2.; Title: strong similarity to transcriptional regulator protein #28 TXREG from patent WO200078954-A2 -Homo sapiens
An14g03220	Similarity: the ORF shows similarity to some putative DNA-J-like chaperones/heat shock proteins.; Title: similarity to hypothetical DNA-J-like protein SPAC4G9.19 - Schizosaccharomyces pombe
An14g03230	Title: weak similarity to hypothetical protein encoded by An13g03440 - Aspergillus niger
An14g03240	Catalytic activity: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH.; Remark: is a medium chain acyl-CoA dehydrogenase (MCADH). the active site glutamic acid of the protein does not lie in the same position as other well characterized MCADH, but in a position present in long chain and isovaleryl acyl-CoA dehydrogenases (LCADH and IVDH).; Similarity: belongs to the acyl-CoA dehydrogenase family.; Title: strong similarity to acyl-CoA dehydrogenase (NADP+) ACDH - Mycobacterium tuberculosis; See PMID 9535763
An14g03250	Catalytic activity: preverential cleavage in B chain of insulin: Asn3-|-Gln,Gly13-|-Ala, Tyr26-|-Thr.; Remark: alternate name is proteinase A.; Remark: proteinase A obtained from the culture medium of Aspergillus niger var. macrosporus is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin, diazoacetyl-DL-norleucine methyl ester, and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; Similarity: belongs to peptidase family a4.; Title: strong similarity to aspergillopepsin II -Aspergillus niger; extracellular/secretion proteins; See PMID 1918059; See PMID 1918060
An14g03270	Title: strong similarity to hypothetical SAM-dependent methyltransferase YOR240w - Saccharomyces cerevisiae
An14g03280	Catalytic activity: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.; Pathway: fourth step in valine and isoleucine biosynthesis. valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: the biosynthesis of branched-chain amino acids (aa) involves three shared pathways through which pyruvate or alpha-ketobutyrate are converted into alpha-keto acids, precursors of valine, leucine or isoleucine.; Similarity: belongs to the dihydroxyacid dehydratase/phosphogluconate dehydratases.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945
An14g03290	Remark: ATP-dependent bile acid transport was abolished when the BAT1 coding region was deleted from the genome and restored upon reintroduction of the gene.; Remark: ATP-dependent transport of bile acids is a key determinant of bile flow in mammalian liver and is associated with cholesterol excretion, gallstone formation,and numerous inherited and acquired hepatobiliary diseases. Secretory vesicles and a vacuole enriched fraction purified from S. cerevisiae also exhibit ATP-dependent bile acid transport.; Remark: alternative names are YLL048c, BAT1.; Similarity: to ABC-type multidrug/protein/lipid transport system, ATPase component.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae; See PMID 9020838; See PMID 9182565
An14g03300	Title: weak similarity to hypothetical protein BAB32722.1 - Oryza sativa
An14g03310	Catalytic activity: D-amino acid + H2O + O2 = 2-oxo acid + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; D-arginine and D-ornithine metabolism.; Remark: strong similarity to D-amino acid oxidase DAO1 patent EP0969088-A/2 from Trigonopsis variabilis.; Remark: the patent is the dao gene with an addition in 5 of a nucleotide coding for a polyhistidine of 6 (hisDAO; Remark: the three C-terminal amino acids of the DAO1 gene of Trigonopsis variabilis encoding a D-amino acid oxidase suggest that the enzyme may be located in peroxisomes.; Similarity: belongs to the DAMOX/DASOX family.; Title: strong similarity to D-amino acid oxidase DAO1 from patent EP0969088-A - Trigonopsis variabilis; See PMID 9434346
An14g03320	Title: weak similarity to hypothetical protein 68B2.60 - Neurospora crassa
An14g03330	Title: similarity to hypothetical protein SCF12.05 -Streptomyces coelicolor
An14g03340	Remark: expression analysis of tfdB (1,2-dichlorophenol hydroxylase (DCPH))and tfdC in Escherichia coli suggested that these genes form one operon, tfdCB.; Title: strong similarity to 1,2-dichlorophenol hydroxylase tfdB - Pseudomonas putida; See PMID 8890750
An14g03350	Remark: weak similarity to fragment of human secreted protein encoded by gene 92 patent WO9947540-A1.; Title: weak similarity to fragment of secreted protein encoded by gene 92 from patent WO9947540-A1 - Homo sapiens
An14g03360	Remark: gene disruption experiments showed that SCT1 is not an essential gene under the standard culture conditions. SCT1 did not suppress a null mutant of ctr1,indicating that a mutant form of choline transporter is necessary for the suppression caused by SCT1.; Title: strong similarity to choline-transport mutant SCT1 supressor protein - Saccharomyces cerevisiae; See PMID 7603986; See PMID 7608137
An14g03370	Catalytic activity: allantoin + H2O = allantoate.; Function: utilization of purines as secondary nitrogen sources, when primary sources are limiting.; Pathway: first step in the degradation of allantoin (purine catabolism).; Remark: DAL1 is expressed in an inducer-independent manner in strain M970 (sigma 1278b genetic background) and modestly responds to mutation of the dal80 locus. Expression was also sensitive to nitrogen catabolite repression (NCR).; Similarity: belongs to the DHOASE family.; Title: strong similarity to allantoinase Dal1 -Saccharomyces cerevisiae; See PMID 1803816
An14g03390	Remark: FluG from E. nidulans has no apparent role in glutamine biosynthesis, but has an enzymatic role in sporulation factor production.; Remark: interaction between fluG and veA influences the production of the extracellular signal and regulates the initiation of conidiation.; Remark: mutations in the Aspergillus nidulans fluG gene disrupt the programmed induction of asexual sporulation and result in formation of fluffy colonies that are characterized by undifferentiated cotton-like masses of vegetative cells.; Similarity: to glutamate-ammonia ligases.; Title: strong similarity to fluG - Aspergillus nidulans; See PMID 7926755; See PMID 8617205; See PMID 9691036; See PMID 11454752
An14g03400	Catalytic activity: carbamoyl phosphate + L-ornithine = orthophosphate + L-citrulline.; Gene-ID: argB; Mapping: argB from A. niger is mapped to chromosome I; see list from DSM.; Pathway: urea cycle and metabolism of amino groups; arginine and proline metabolism.; Remark: putative sequencing error at positions 56475, 56488 and 56513 generating Frame shifts.; Remark: the N terminus, which shows little or no homology to other OCTases, is highly basic and is probably involved in mitochondrial targeting.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Similarity: belongs to the OCTase family.; localisation:mitochondrion; See PMID 3443301
An14g03410	Remark: also strong similarity with EST an_3520 Aspergillus niger.; Remark: strong similarity to the 3'-untranslated region of the A. niger argB gene encoding ornithine carbamoyl transferase.; Remark: the corresponding gene in potato is of low copy number, is expressed in a variety of tissues, and encodes a protein which includes several domains with similarity to database sequences, including ferredoxin from Clostridium pasteurianum. Expression of the cDNA in E. coli yields a fusion protein with sucrolytic activity.; Title: similarity to sucrose cleavage protein -Solanum tuberosum; See PMID 7957893
An14g03420	Remark: proteins containing C-terminal 'CAAX' sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenyl lipid, proteolysis of the C-terminal -AAX tripeptide, and methylation of the carboxyl group of the now C-terminal prenylcysteine.; Remark: the human RCE1 gene product is bona fide a prenyl protein protease and play a major role in the processing of CAAX-type prenylated proteins.; Title: strong similarity to CAAX prenyl protein protease RCE1 - Homo sapiens; See PMID 10085068
An14g03430	Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: northern blot analysis and reverse transcriptase-polymerase chain reaction (RT-PCR) studies demonstrated that the gene moxY, is expressed concurrently with genes involved in aflatoxin biosynthesis. Therefore,the two putative aflatoxin pathway genes cypX and moxY followed by a 5-kb non-coding region of DNA define one end of the boundary of the aflatoxin pathway gene cluster in A. parasiticus.; Similarity: the ORF is longer than moxY of A. parasiticus (620 compared to 481 amino acids).; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719
An14g03440	Remark: cercosporin, a photosensitizing perylenequinone toxin produced by the plant pathogenic Cercospora fungi, generates the highly toxic singlet oxygen (1O2) upon exposure to light. Cercosporin shows broad toxicity against a wide range of organisms, including bacteria, fungi, plants, and animals; however, Cercospora fungi are resistant to its effects.; Remark: targeted disruption of crg1 resulted in mutants that, like CS10, are sensitive to cercosporin. However, unlike CS10, crg1 disruption mutants are not down-regulated in toxin production. Both CS10 and the crg1 disruption mutants are unaffected in their response to other 1O2-generating photosensitizers, suggesting that CRG1 functions specifically against cercosporin, rather than against 1O2.; Title: similarity to cercosporin resistance protein crg1 - Cercospora nicotianae; See PMID 10517336
An14g03450	Remark: similarity to human secreted protein, SEQ ID NO: 8103 patent EP1033401-A2.; Similarity: to dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to secreted protein SEQ ID NO:8103 from patent EP1033401-A2 - Homo sapiens
An14g03460	Remark: similarity to Leishmania antigen M15 protein patent WO9835045-A2.; Title: similarity to antigen M15 from patent WO9835045-A2 - Leishmania sp.
An14g03470	Function: antibodies raised against different domains of C-Nap1 from H. sapiens prove that this protein dissociates from spindle poles during mitosis, but reaccumulates at centrosomes at the end of cell division.; Function: the centrosomal protein C-Nap1 from H. sapiens is required for cell cycle-regulated centrosome cohesion.; Localization: antibodies raised against recombinant C-Nap1 from H. sapiens produced strong labeling of centrosomes by immunofluorescence, and immunoelectron microscope revealed that C-Nap1 is associated specifically with the proximal ends of both mother and daughter centrioles.; Phenotype: antibody-mediated interference with C-Nap1 from H. sapiens function causes centrosome splitting, regardless of the cell cycle phase.; Remark: human C-Nap1 was first identified as a human Nek2-interacting protein in a yeast two-hybrid screen.; Title: similarity to centrosomal Nek2-associated protein C-NAP1 - Homo sapiens; nucleus; See PMID 9647649; See PMID 11076968
An14g03490	Title: weak similarity to Son of sevenless protein Sos from patent WO200005258-A1 - Drosophila melanogaster
An14g03500	Catalytic activity: D-Xylulose 5-phosphate + Formaldehyde = Glyceraldehyde 3-phosphate + Glycerone.; Cofactor: Thiamine diphosphate.; Phenotype: a das1 deletion strain of C. boidinii has completely lost the ability to grow on methanol,; Title: strong similarity to dihydroxyacetone synthase DAS1 - Candida boidinii; peroxisome; See PMID 9811645
An14g03510	Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH.; Pathway: the rat Sorbitol dehydrogenase SDH is involved in the fructose and mannose metabolism.; Remark: two isoforms of SDH from R. norvegicus are produced by use of alternative initiation codons in the same reading frame.; Title: strong similarity to sorbitol dehydrogenase SDH - Rattus norvegicus; See PMID 8223590; See PMID 8761460
An14g03520	Function: Dfg5 from S. cerevisiae is required for filamentous growth, cell polarity, and cellular elongation.; Phenotype: a dfg5 mutant of S. cerevisiae blocks filamentous growth.; Remark: the synonym for Dfg5 from S. cerevisiae is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077
An14g03530	Function: Pth11 of M. grisea is involved in host surface recognition but is not required for appressorium morphogenesis.; Function: Pth11 of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: a M. grisea Pth11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Phenotype: pth11 mutants of the M. grisea strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An14g03540	Title: similarity to hypothetical protein encoded by An08g01290 - Aspergillus niger
An14g03550	Phenotype: the dal5 deletion mutant of S. cerevisiae is viable but unable to transport allontoate or ureidosuccinate.; Remark: synonyms for Dal5 from S. cerevisiae are Urep1 and YJR152w.; Repression: DAL5 is constitutively expressed in S. cerevisiae but DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; cytoplasm; See PMID 3294799; See PMID 3301804; See PMID 3549700
An14g03560	Catalytic activity: hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs; no action on Pro-|-Pro.; Cofactor: Manganese.; Remark: Microbacterium esteraromaticum = Aureobacterium esteraromaticum.; Remark: the best substrate for the prolidase from A. esteraromaticum is Pro-Hyp.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239
An14g03570	Function: AtrB from A. nidulans is a multidrug ABC transporter and has affinity to substrates belonging to all major classes of agricultural fungicides and some natural toxic compounds.; Function: AtrB of A. nidulans acts by preventing intracellular accumulation of the toxicant.; Function: cDNA of atrB from A. nidulans can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Induction: The transcription of atrB in mycelium of A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Phenotype: atrB deletion mutants of A. nidulans displayed increased sensitivity to anilinopyrimidine,benzimidazole, phenylpyrrole, phenylpyridylamine,strobirulin and some azole fungicides.; Remark: Emericella nidulans = Aspergillus nidulans.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; plasma membrane; See PMID 9180695; See PMID 10931903
An14g03580	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:23028 from patent EP1033405-A2 - Arabidopsis thaliana
An14g03590	Function: Nopp 140 functions as a transcriptional activator .; Localization: Nopp140 from R. norvegicus shuttles on tracks between nucleolus and cytoplasm.; Remark: Nopp140 is one of the most phosphorylated proteins in the cell, and nuclear localization signal (NLS) binding of Napp140 was dependent on phosphorylation.; Similarity: the similarities are mainly based on repetetive structures.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein Nopp140 - Rattus norvegicus; nucleus; See PMID 8972203; See PMID 1623516
An14g03600	Title: similarity to hypothetical protein SPAC56F8.12 - Schizosaccharomyces pombe
An14g03610	Phenotype: Disruption of TRI11 of F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: The TRI11 gene of F. sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides [putative sequencing error]; putative sequencing error; See PMID 9435078
An14g03620	Phenotype: deletion of YJL010C in S. cerevisiae is lethal.; Remark: there are no further informations about the patent available.; Title: strong similarity to essential protein YJL010c from patent WO200039342-A2 - Saccharomyces cerevisiae
An14g03630	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also strong similarities to RNA helicases.; Title: strong similarity to protein fragment SEQ ID NO:48636 from patent EP1033405-A2 - Arabidopsis thaliana
An14g03640	Catalytic activity: Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Cofactor: FAD.; Function: salA from Acinetobacter was cloned into pUC18 together with salR and salE, and its gene product showed salicylate-inducible hydroxylase activity against a range of substituted salicylates.; Title: strong similarity to salicylate hydroxylase salA - Acinetobacter sp.; See PMID 10715011
An14g03650	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to syndecan-1 gene Xsyn-1 -Xenopus laevis
An14g03660	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also strong similarities to putative membrane proteins.; Title: strong similarity to protein fragment SEQ ID NO:22357 from patent EP1033405-A2 - Arabidopsis thaliana; plasma membrane
An14g03670	Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Bos taurus
An14g03700	Title: weak similarity to protein fragment SEQ ID NO:52297 from patent EP1033405-A2 - Arabidopsis thaliana
An14g03710	Phenotype: mis5 deletion in S. pombe results in DNA replication defect and hypersensitivity to UV ray and hydroxyurea.; Phenotype: mis5 mutation in S. pombe leads to high loss rates of minichromosomes.; Remark: mis5 is essential for viability.; Similarity: mis5 from S. pombe encodes a novel member of the ubiquitous MCM family required for the onset of replication.; Title: strong similarity to replication licensing factor mis5p - Schizosaccharomyces pombe; See PMID 7865880
An14g03720	Function: RAD5 of S. cerevisiae has single-stranded DNA-dependent ATPase activity, and is involved in error-free DNA repair.; Remark: RAD5 of S. cerevisiae is also called REV2,SNM2 or YLR032W.; Similarity: the predicted ORF shows equally strong similarity to the S. cerevisiae RAD5 protein, a putative helicase of S. pombe, the DNA repair protein RAD16 of S. cerevisiae and other related proteins from diverse eucaryotic species.; Title: strong similarity to DNA repair protein Rad5 - Saccharomyces cerevisiae; See PMID 8290359; See PMID 1324406; See PMID 9016623; See PMID 9637242; See PMID 10430580
An14g03730	Induction: transcription of M14 from M. musculus is dramatically induced (about 70-fold) by isoproterenol treatment.; Similarity: the ORF also shows strong similarity to the EST SEQ ID NO:4359 of patent WO200056762-A2 from Aspergillus niger.; Similarity: the similarities are based on repetetive structures.; Title: similarity to hypothetical proline-rich protein M14 - Mus musculus; See PMID 2839509
An14g03740	Title: strong similarity to hypothetical protein SPCC14G10.02 - Schizosaccharomyces pombe
An14g03760	Title: weak similarity to endoglucanase from patent WO9110732-A - Bacillus sp.
An14g03770	Remark: expression of human HRH1 in a S. cerevisiae prp22 (RNA helicase) mutant can partially rescue its temperature-sensitive phenotype.; Title: strong similarity to RNA helicase 1 HRH1 -Homo sapiens; nucleus; See PMID 7935475
An14g03780	Function: the DExH box protein Suv3p from S. cerevisiaeis a component of a yeast mitochondrial 3'-to-5' exoribonuclease that suppresses group I intron toxicity.; Remark: synonyms for Suv3 from S. cerevisiae are Lpb2 and YPL029w.; Title: strong similarity to mitochondrial RNA helicase Suv3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8565066; See PMID 1379722
An14g03790	Function: Microinjection of Sec1 from L. pealei into the presynaptic terminal of the giant synapse inhibited evoked neurotransmitter release, but this effect was prevented by coinjecting the cytoplasmic domain of L. pealei syntaxin, one of the binding partners of Sec1.; Remark: Sec1-related proteins are essential for membrane fusion at distinct stages of the constitutive and regulated secretory pathways in eukaryotic cells.; Title: strong similarity to sec1-like protein -Loligo pealei; See PMID 9526009
An14g03800	Title: weak similarity to sexual differentiation protein esc1p - Schizosaccharomyces pombe
An14g03810	Similarity: the protein shows weaker similarity to a human patented sequence (patent number EP1067182-A2) and a number of hypothetical proteins, some of which annotated as oxidoreductases with various specificity; the predicted protein indeed contains structural features common to short-chain alcohol dehydrogenases.; Title: strong similarity to hypothetical protein SPAC19A8.06 - Schizosaccharomyces pombe
An14g03820	Function: GAL10 of S. cerevisiae converts UDP-glucose to UDP-galactose, being involved in the galactose metabolism pathway.; Similarity: the predicted protein shows a very strong similarity to the N-terminal half of GAL10 of S. cerevisiae; the C-terminal half of the yeast gene is missing from the predicted protein.; Title: strong similarity to UDP-glucose 4-epimerase Gal10 - Saccharomyces cerevisiae; cytoplasm; See PMID 7601342
An14g03850	Function: TRI4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis.; Phenotype: disruption of TRI4 results in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the TRI4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An14g03870	Function: AvnA is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Remark: as other polyketides, aflatoxins are synthesized by condensation of acetate units.; Similarity: The avnA gene encodes a cytochrome P-450-type monooxygenase that has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431
An14g03890	Complex: PAT1 of S. cerevisiae interacts with the Lsm decapping complex.; Function: PAT1 of S. cerevisiae is involved in mRNA decapping and degradation, as well as for faithful chromosome transmission during mitosis and meiosis.; Similarity: the alignment of the predicted protein to PAT1 of S. cerevisiae has several gaps; a better alignment is obtained to the putative S. pombe homologue of S. cerevisiae PAT1.; Title: similarity to topoisomerase II-associated protein Pat1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8816497; See PMID 8972867; See PMID 9077451; See PMID 10394921; See PMID 10913177
An14g03910	Function: kre2 of C. albicans is involved in the synthesis of mannoproteins, the third major class of macromolecule found in the cell wall.; Function: kre2 of C. albicans transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage.; Golgi; Phenotype: both heterozygous and homozygous kre2 null mutants of C. albicans showed strong attenuation of virulence in guinea pig and mouse models of systemic candidosis, which, in guinea pigs, could be attributed to a decreased ability to reach and/or adhere internal organs.; Phenotype: the absence of kre2 in C. albicans reduced the ability of C. albicans cells to adhere to each other, to human buccal epithelial cells, and to rat vaginal epithelial cells.; Remark: kre2 of C. albicans is also called mnt1.; Title: strong similarity to alpha-1,2-mannosyltransferase kre2 - Candida albicans
An14g03920	Similarity: the predicted ORF is 60 amino acids longer at its N-terminus than other S12 proteins.; Title: strong similarity to ribosomal protein of the small subunit Rps12 - Saccharomyces cerevisiae; See PMID 11279123
An14g03930	Function: the S. cerevisiae Ump1p is a chaperone and component of proteasome precursor complexes containing unprocessed beta subunits but is not detected in the mature 20S proteasome.; Induction: the propeptide of the Pre2p/Doa3p beta subunit is required for ump1p's function in proteasome maturation.; Induction: transcript levels of mammalian ump1 are increased after IFN-gamma treatment.; Phenotype: S. cerevisiae cells lacking ump1 exhibit a lack of coordination between the processing of beta subunits and proteasome assembly, resulting in functionally impaired proteasomes.; Remark: UMP1 of S. cerevisiae is also called YBR173C or YBR12.; Title: strong similarity to proteasome 20S maturation factor Ump1 - Saccharomyces cerevisiae; See PMID 9491890; See PMID 10757750; See PMID 10973495
An14g03950	Title: strong similarity to hypothetical protein EAA60774.1 - Aspergillus nidulans
An14g03980	Title: strong similarity to hypothetical 57.9 kd protein - Schizosaccharomyces pombe
An14g03990	Remark: the systematic name of hxt5 from S. cerevisiae is YHR096C.; Similarity: the ORF shows similarity to several sugar transporter from different species.; Title: strong similarity to hexose transporter Hxt5 - Saccharomyces cerevisiae; plasma membrane; See PMID 7651133
An14g04000	Function: the regulatory gene amdR of A. oryzae positively regulates the expression of genes involved in the catabolism of certain amides, omega amino acids and lactams.; Induction: amdR of A. oryzae can be induced by omega amino acids.; Phenotype: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae.; Similarity: the similarity of the predicted ORF to amdR from A. oryzae is locally high the N-terminal part of the ORF, ending around amino acid 457.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; nucleus; See PMID 2188110; See PMID 1452021
An14g04010	Catalytic activity: Erg8 of S. cerevisiae converts ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.; Pathway: second step in isopentenyl diphosphate formation.; Phenotype: disruption of the chromosomal erg8 coding region in S. cerevisiae by integration of URA3 or HIS3 marker fragments was lethal in haploid cells, indicating that this gene is essential.; Remark: Erg8 of S. cerevisiae is also called YMR220W or YM9959. 02.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760517.; Title: strong similarity to phosphomevalonate kinase Erg8 - Saccharomyces cerevisiae; cytoplasm
An14g04040	Remark: a splice site was detected upstream of the START codon.; Similarity: the similarity of the predicted ORF to the hypothetical protein from S. pombe is locally high at its C-terminal end starting around amino acid 850.; Title: strong similarity to hypothetical protein SPAC1093.01 with conserved domain PF01535 duf17p -Schizosaccharomyces pombe
An14g04050	Catalytic activity: pdx3 of S. cerevisiae converts pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.; Induction: due to the presence of gcn4p binding sequences in the pdx3 promoter region it is assumed that transcription of this gene is under the general control of nitrogen.; Pathway: de novo synthesis of pyridoxine (vitamine B6) and pyridoxal phosphate.; Remark: alternate names for pdx3 of S. crevisiae are YBR032 or YBR035c.; Similarity: the ORF overlaps with A. niger EST PATENTDNA:AAF11550 EST SEQ ID NO:4073.; Similarity: the similarity of the ORF to pdx3 of S. cerevisiae is restricted to the inner part of the ORF,spanning the region between amino acid 105 and 285.; Title: strong similarity to pyridoxamine-phosphate oxidase Pdx3 - Saccharomyces cerevisiae
An14g04060	Function: clcn3 of M. musculus is an voltage-gated channel, which is active in chloride transport.; Remark: an alternative name for clcn3 is clc3.; Title: strong similarity to chloride channel 3 clcn3 - Mus musculus [putative frameshift]; putative frameshift; See PMID 7665160
An14g04070	Function: cbf-C of R. norvegicus is forming together with cbf-A and cbf-B the cbf-DNA complex, which binds to CCAAT motifs present in many eukaryotic promoters.; Similarity: a significant similarity of the predicted ORF to CCAAT binding transcription factor C subunits of several species starts with amino acid 100 of the ORF.; Title: similarity to CCAAT binding transcription factor subunit C cbf-C - Rattus norvegicus; nucleus; See PMID 7878029
An14g04080	Function: rip1 from S. pombe is part of the respiratory chain complex in the inner mitochondrial membrane (complex III or cytochrome b-c1).; Remark: rip1 from S. pombe is also called Rieske iron-sulfur protein or rsp.; Remark: the systematic name of rip1 from S. pombe is SPBC16H5. 0.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:AN754, PATENTDNA:AAF11289 EST SEQ ID NO:3812 and PATENTDNA:AAF14587 EST SEQ ID NO:7110.; Title: strong similarity to iron-sulfur subunit of ubiquinol--cytochrome c reductase rip1p -Schizosaccharomyces pombe; localisation:mitochondrion
An14g04090	Similarity: the ORF shows similarity to the homologues protein of she9 from C. albicans, SPAC823. 13c from S. pombe and YDR393w from S. cerevisiae.; Similarity: the similarity of the ORF to these hypothetical proteins is restricted to its innner part,spanning the region from amino acid 150 to 350.; Title: strong similarity to hypothetical protein she9 - Candida albicans
An14g04100	Similarity: some of the hypothetical protein are putative membrane proteins and/or stress responsive.; Similarity: the similarity to several hypothetical proteins is restricted to the first third of the ORF,ending around amino acid 60.; Title: similarity to hypothetical protein ZK632.10 -Caenorhabditis elegans
An14g04110	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An14g04130	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An14g04140	Function: c-cam105 is conferring the ability to pump out [3H]taurocholate when expressed in cos cells.; Function: c-cam105 of R. norvegicus is a calcium-independent cell adhesion molecule, which may play a role in the formation and maintainance of the structure of the apical surface of rat hepatocytes.; Induction: phosphorylation of the cytoplasmic tail of c-cam105 is essential for bile acid efflux activity but not for ATPase activity.; Remark: c-cam105 of R. norvegicus is also called C-CAM, ATP-dependent taurocolate-carrier protein or gp110.; Similarity: the ORF shows similarity to several serine-rich proteins.; Similarity: the predicted ORF is 184 amino acids shorter at its N-terminus than c-cam105 of R. norvegicus.; Title: similarity to ecto-ATPase c-cam105 - Rattus norvegicus; plasma membrane; See PMID 8380406; See PMID 8420979
An14g04150	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An14g04160	Function: cofilin cof1 of S. cerevisiae is an essential component of the yeast cortical cytoskeleton, a low-molecular weight actin-binding and depolymerizing protein with several activities in vitro.; Induction: cofilin activity is regulated by phosphorylation.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for cof1 of S. cerevisiae is YLL050C.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE759006 and EMBLEST:BE759053.; Title: strong similarity to cofilin Cof1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 4055781; See PMID 9078368; See PMID 10231390
An14g04170	Function: cytochrome c oxidase subunit V cox5 of A. niger is part of the respiratory chain of the mitochondrial oxidative phosphorylation process.; Gene-ID: cox5; Remark: the ORF is C-terminally truncated due to the contig border.; Similarity: the ORF overlaps with EMBL:ANI132229 (A. niger cox5 gene, exons 1-3) and PATENTDNA:AAF11256 (A. niger EST SEQ ID NO:3779).; localisation:mitochondrion; See PMID 10503533; See PMID 11245784
An14g04180	Catalytic activity: H+-transporting ATP synthases produce a proton gradient and convert ADP + phosphate <=> ATP + H(2)O.; Remark: the ORF is N-terminally truncated (330 to 340 amino acids) due to contig border.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE758985.; Title: strong similarity to H+-transporting ATP synthase beta chain - Neurospora crassa [truncated ORF]; localisation:mitochondrion
An14g04190	Function: glc3 of S. cerevisiae is involved in glycogen/starch biosynthesis by catalyzing the transglycosylation of a terminal segment of a 1,4-alpha-D-glucan chain to an unbranched chain, thereby converting amylose to amylopectin or creating branches in glycogen.; Induction: glc3 of S. cerevisiae is expressed during the transition between the late exponential and stationary growth phases, coincident with maximal glycogen accumulation.; Phenotype: the null mutant of glc3 in S. cerevisiais is viable, but glycogen deficient.; Remark: glc3 of S. cerevisiae is also called gha1 or YEL011W.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760568.; Title: strong similarity to 1,4-alpha-glucan branching enzyme Glc3 - Saccharomyces cerevisiae; cytoplasm; See PMID 8150278; See PMID 1634552; See PMID 1729600
An14g04200	Function: rhamnogalacturonase rhgB of A. niger is involved in the oligoglycosyl fragment generation from the backbone of rhamnogalacturonan, a component of cell walls by hydrolysing the 1,4-alpha-D-galactosiduronic linkages.; Gene-ID: rhgB; Induction: the rhgB gene of A. niger was derepressed after 18 h of growth on either apple pectin or sucrose.; Similarity: the ORF is identical to the database entry for the A. niger rhgB protein, but differs at amino acid 226 (G to S), which lies in a splice site.; Similarity: the ORF overlaps nearly completely with A. niger EST EMBL:ANRHGBGEN (rhgB gene).; See PMID 9299700
An14g04210	Remark: the similarity of the predicted ORF to the Drosophila gene reaches over its whole lenght.; Title: similarity to hypothetical protein encoded by An07g05660 - Aspergillus niger
An14g04220	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An14g04230	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An14g04240	Similarity: the ORF shows strong similarity to several conserved hypothetical proteins from bacteria,which are immunoreactive antigens.; Title: strong similarity to hypothetical conserved protein CC0533 - Caulobacter crescentus
An14g04260	Title: strong similarity to hypothetical protein PA4181 - Pseudomonas aeruginosa
An14g04280	Function: qutD of A. nidulans is required for the transport of quinate into the mycelium.; Similarity: qutD of A. nidulans belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; plasma membrane; See PMID 2835177; See PMID 2976880
An14g04290	Title: strong similarity to hypothetical amidase -Schizosaccharomyces pombe
An14g04300	Title: strong similarity to molybdenum cofactor biosynthetic protein - Aspergillus nidulans; See PMID 9614089; See PMID 10383438
An14g04320	Title: strong similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe
An14g04330	Title: similarity to hypothetical short chain alcohol dehydrogenase cta - Cucumis sativus
An14g04340	Function: urdJ from Streptomyces fradiae is involved in the urdamycin biosynthetis.; Title: similarity to transporter involved in urdamycin biosynthesis - Streptomyces fradiae; See PMID 10658661
An14g04360	Title: questionable ORF
An14g04370	Gene-ID: pelA; See PMID 1934134; See PMID 2225145
An14g04395	Catalytic activity: EC 1. 3. 5. 1 catalyzes the transfer of two electrons from succinate to ubiquinon via FAD yielding fumarate and ubiquinol.; Complex: Sdh2p of S. cerevisiae forms part of the heterotetrameric Succinate dehydrogenase complex (complex II) consisting of a flavoprotein (Sdh1p), an iron-sulfur protein (Sdh2p), a cytochrome b and a membrane-anchoring protein.; Function: Sdh2p of S. cerevisiae contains three different iron-sulfur clusters.; Localization: the SDH complex of S. cerevisiae is integrated in the mitochondrial inner membrane.; Pathway: EC 1. 3. 5. 1 is a key enzyme in the tricarboxylic-acid cycle.; Remark: the ORF continues on the adjacent contig.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to succinate dehydrogenase iron-sulfur protein subunit Sdh2 - Saccharomyces cerevisiae [truncated ORF]; localisation:mitochondrion; See PMID 9822678; See PMID 2191948
An14g04400	Catalytic activity: EC 1. 3. 5. 1 catalyzes the transfer of two electrons from succinate to ubiquinon via FAD yielding fumarate and ubiquinol.; Complex: Sdh2p of S. cerevisiae forms part of the heterotetrameric Succinate dehydrogenase complex (complex II) consisting of a flavoprotein (Sdh1p), an iron-sulfur protein (Sdh2p), a cytochrome b and a membrane-anchoring protein.; Function: Sdh2p of S. cerevisiae contains three different iron-sulfur clusters.; Localization: the SDH complex of S. cerevisiae is integrated in the mitochondrial inner membrane.; Pathway: EC 1. 3. 5. 1 is a key enzyme in the tricarboxylic-acid cycle.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to succinate dehydrogenase iron-sulfur protein subunit Sdh2 - Saccharomyces cerevisiae [truncated ORF]; localisation:mitochondrion; See PMID 2191948; See PMID 9822678
An14g04410	Catalytic activity: EC 4. 1. 2. 13 catalyses the reversible cleavage of fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.; Complex: fructose-1,6-bisphosphate aldolase of T. aquaticus forms a homotetramer.; Pathway: EC 4. 1. 2. 13 is an enzyme of the glycolysis and gluconeogenesis pathways.; Title: strong similarity to fructose-1,6-bisphosphate aldolase - Thermus aquaticus; cytoplasm; See PMID 8898912; See PMID 11173490; See PMID 11237691
An14g04420	Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.; Remark: the amino acid sequence of 3-hydroxyisobutyrate dehydrogenase shows similarity to several other pyridine nucleotide-dependent dehydrogenases. The resemblance to malate and lactate dehydrogenases suggests that the nucleotide-binding domain is located in the N-terminal region of the protein.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase - Rattus norvegicus; See PMID 1339433; See PMID 2647728
An14g04440	Title: questionable ORF
An14g04460	Title: questionable ORF
An14g04490	Title: weak similarity to hypothetical protein AF1318 - Archaeoglobus fulgidus
An14g04510	Title: similarity to essential protein #47 WO2003076464-A2 - Aspergillus fumigatus
An14g04530	Function: ORF4 is part of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor but it does not seem to be involved directly in actinorhodin biosynthesis.; Remark: also similar to human patent PATENTPROT:Y14147.; Title: similarity to hypothetical protein actVA-ORF4 - Streptomyces coelicolor; See PMID 1766437; See PMID 7929165
An14g04560	Title: strong similarity to hypothetical protein B15I20.30 - Neurospora crassa
An14g04590	Similarity: KCS1 of S. cerevisiae is similar to the basic leucine zipper family of transcription factors.; Title: strong similarity to transcription factor Kcs1 - Saccharomyces cerevisiae
An14g04620	Title: strong similarity to hypothetical protein EAA35125.1 - Neurospora crassa
An14g04630	Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger
An14g04640	Title: strong similarity to hypothetical protein EAA58284.1 - Aspergillus nidulans
An14g04650	Function: A. nidulans palH is one of the components of the ambient pH signal transduction pathway (Pal pathway).; Title: strong similarity to pH signal transductions protein palH - Aspergillus nidulans; See PMID 10476033; See PMID 10821185
An14g04660	Title: similarity to hypothetical conserved protein PA2839 - Pseudomonas aeruginosa
An14g04670	Title: weak similarity to hypothetical protein encoded by An01g13670 - Aspergillus niger [putative sequencing error]; putative sequencing error
An14g04710	Alternative name: proctase B; Catalytic activity: pepA generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen.; Function: pepA has properties of pepsin-type aspartic proteinases and hydrolyses proteins with broad specificity.; Gene-ID: pepA; Mapping: pepA from A. niger is mapped to chromosome I; see list from DSM, PUBMED 9309173.; Remark: A. niger macrosporus excretes two types of acid endopeptidases, the major one is proctase B/aspergillopepsin I, and the minor one is proctase A.; extracellular/secretion proteins
An14g04720	Function: S. cerevisiae ARO80 is involved in positive regulation of aromatic amino acid synthesis through positive regulation of ARO9 and ARO10/YDR380W.; Remark: S. cerevisiae ARO80 is a member of the Zn2Cys6 transcription factor family.; Remark: the systematic name for S. cerevisiae ARO80 is YDR421w.; Title: similarity to transcription factor Aro80 -Saccharomyces cerevisiae; See PMID 10207060
An14g04730	Function: disruption of human UVRAG gives rise to developmental defects including complex cyanotic heart defects, altered lung lobation, symmetric liver, and abnormally lobulated spleen.; Function: human UVRAG is able to complement partially the ultraviolet sensitivity of a xeroderma pigmentosum cell line.; Similarity: the strongest similarity of the ORF is to a hypothetical p63 related protein of Neurospora crassa.; Title: strong similarity to UVRAG - Homo sapiens; See PMID 9169138; See PMID 10798355
An14g04740	Title: weak similarity to hypothetical protein SPBC18H10.17c - Schizosaccharomyces pombe
An14g04750	Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis
An14g04760	Function: S. chinensis FAR is an alcohol-forming fatty acyl-coenzyme A reductase required for the production of esters of long-chain alcohols and fatty acids (waxes).; Title: similarity to acyl CoA reductase FAR -Simmondsia chinensis; See PMID 10712526
An14g04770	Function: S. cerevisiae Ptc1 inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1.; Function: S. cerevisiae Ptc1 negatively affects PBS2 action, regulating cell wall beta-glucan assembly.; Remark: Ptc1 of S. pombe is a type 2C Ser/Thr phosphatase, one of the three major families of structurally unrelated eukaryotic protein phosphatases.; Title: strong similarity to phosphoprotein phosphatase 2C ptc1p - Schizosaccharomyces pombe; See PMID 7565587; See PMID 8196617; See PMID 11113180
An14g04780	Similarity: similarity is from predicted A. niger protein to C-terminus of mouse, rat and human hairless,which are all about 1000 aa longer.; Title: weak similarity to transcription factor hairless - Mus musculus [putative sequencing error]; putative sequencing error; See PMID 8052649
An14g04790	Catalytic activity: PPiases catalyse the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: PPiases accelerate the folding of proteins.; Similarity: S. pombe SPAC21E11. 05C belongs to the cyclopholin family of prolyl isomerases, the other two PPI families are, FK506-binding proteins (FKBPs) and parvulins.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase SPAC21E11.05C - Schizosaccharomyces pombe; See PMID 10424896; See PMID 2204030
An14g04800	Title: strong similarity to protein SEQ ID 2451 from patent EP1258494-A1 - Saccharomyces cerevisiae
An14g04810	Remark: the predicted ORF is only 79 amino acids long and contains relatively long introns.
An14g04820	Remark: the predicted ORF contains relatively long introns.
An14g04830	Function: S. cerevisiae Pif1 is a 5'-to-3' DNA helicase.; Function: it has been proposed that S. cerevisiae Pif1p-mediated inhibition of telomerase promotes genetic stability by suppressing telomerase-mediated healing of double-strand breaks.; Function: mutations in S. cerevisiae pif1 cause telomere lengthening and a large increase in the formation rate of new telomeres.; Title: strong similarity to helicase Pif1 -Saccharomyces cerevisiae; See PMID 10693764; See PMID 10926538
An14g04840	Title: similarity to hypothetical O-methyl transferase EncK - Streptomyces maritimus
An14g04850	Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity; some of the typical domains present in polyketide synthases are recognized in the predicted ORF.; Function: pimS2 of S. natalensis is involved in the biosynthesis of the polyene macrolide pimaricin, important in the food industry as a preservative to prevent mould contamination of foods.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to different fungal polyketide synthases.; Title: strong similarity to pimaricin polyketide synthase pimS2 - Streptomyces natalensis; See PMID 11094342
An14g04860	Complex: Rad4 of S. pombe may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis.; Function: Rad4 of S. pombe is an essential component for DNA replication and also the checkpoint control system which couples S and M phases.; Title: strong similarity to S-M checkpoint control protein rad4p - Schizosaccharomyces pombe; nucleus; See PMID 8343962; See PMID 9268024; See PMID 1762905
An14g04870	Complex: FZO1 of S. cerevisiae is part of a larger protein complex of 800 kDa.; Function: FZO1 is a GTPase required for the biogenesis of functional mitochondria in S. cerevisiae.; Localization: FZO1 of S. cerevisiae is an integral protein of the mitochondrial outer membrane exposing its major part to the cytosol.; Remark: FZO1 of S. cerevisiae is also known as YBR179C.; Similarity: A. niger EST EMBLEST:BE759505 comprises the last exon and the probable 3'-UTR of the predicted gene.; Similarity: the N-terminal region of the predicted ORF shows no similarity to FZO1 of S. cerevisiae.; Title: strong similarity to fuzzy onions homolog Fzo1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9230308; See PMID 9685359; See PMID 9891785
An14g04880	Function: DID4 (Doa4-independent degradation gene n. 4) of S. cerevisiae encode a component of the vacuolar protein-sorting (Vps) pathway.; Function: in particular, DID4 of S. cerevisiae belongs to the class E of Vps factors, which function in the maturation of a late endosome/prevacuolar compartment into multivesicular bodies that then fuse with the vacuole.; Remark: DID4 of S. cerevisiae is also known as YKL002W.; Title: strong similarity to class E vacuolar-protein sorting factor Did4 - Saccharomyces cerevisiae; See PMID 11029042
An14g04890	Function: the ability of AFC1 of A. thaliana of restoring the functionality of a compromised signal transduction pathway, was experimentally verified in a mutant strain of S. cerevisiae.; Similarity: the main feature of the predicted ORF is the presence of different structural regions common to various protein kinases.; Similarity: the predicted ORF contains three protein kinase domains and a leucine zipper motiv, usually involved in protein-protein interaction especially in gene regulatory proteins.; Similarity: the predicted ORF is also similar to human calcium-calmodulin dependent protein kinase I.; Title: similarity to protein kinase AFC1 -Arabidopsis thaliana; See PMID 7641687; See PMID 7991592
An14g04910	Similarity: the similarity is limited to the central part of the molecules and is mainly due to repetitive amino acid stretches.; Title: weak similarity to GABA-A receptor epsilon-like subunit epsilon - Rattus norvegicus; See PMID 10804200
An14g04920	Catalytic activity: triose-phosphate isomerase catalyzes the reversible isomerization: D-glyceraldehyde 3-phosphate <=> dihydroxy-acetone phosphate.; Complex: triose-phosphate isomerase is a homodimer.; Gene-ID: tpiA; Pathway: triose-phosphate isomerase plays an important role in several metabolic pathways, starting from the glycolysis.; cytoplasm; See PMID 6762366; See PMID 10916682; See PMID 11257493; See PMID 3521890
An14g04930	Function: MDM10 of P. anserina is implicated in the maintenance of mitochondrial morphology and distribution.; Phenotype: MDM10 mutants in P. anserina accumulate specific deleted mitochondrial genomes during senescence.; Title: strong similarity to mitochondrial outer membrane protein MDM10 - Podospora anserina; localisation:mitochondrion; See PMID 9343397
An14g04940	Phenotype: S. cerevisiae MRT4 null mutants are viable, are not defective in protein synthesis, but have defects in mRNA decay and growth.; Remark: MRT4 of S. cerevisiae is also known as YKL009W.; Similarity: the predicted ORF contains, indeed,structural characteristics common to ribosomal or RNA-binding proteins.; Similarity: the predicted ORF shows strong similarity to a plenty of putative proteins annotated as acidic ribosomal protein P0; comparison to the validated P0 proteins, and especially the lack of the typical acidic C-terminus, suggest caution in accepting such a classification.; Similarity: the stronger described homologue, MRT4 of S. cerevisiae, is more likely involved in RNA degradation than in protein synthesis, suggesting it is not a ribosome component.; Title: strong similarity to mRNA turnover 4 protein Mrt4 - Saccharomyces cerevisiae; See PMID 10471698; See PMID 3323886
An14g04950	Complex: snRNP27D of D. melanogaster is a component of the U1 small nuclear ribonucleoprotein (snRNP) complex.; Function: U1 snRNP is required at an early stage during assembly of the spliceosome, the dynamic RNP complex that performs nuclear pre-mRNA splicing.; Similarity: activity and composition of the U1 snRNP are highly conserved in all metazoans.; Title: strong similarity to 70K U1 small nuclear ribonucleoprotein snRNP27D - Drosophila melanogaster; nucleus; See PMID 1692955; See PMID 11333025
An14g04960	Similarity: the predicted gene is nearly identical to A. niger EST EMBLEST:BE759452; another A. niger EST (EMBLEST:BE759721) likely corresponds to the polyadenylation signal and the 3'-UTR of the gene.; Title: strong similarity to protein fragment SEQ ID NO:40372 from patent EP1033405-A2 - Zea mays
An14g04970	Similarity: most BLASTP hits are due to polyproline stretches.; Title: weak similarity to hypothetical zinc-finger protein SPAC19A8.10 - Schizosaccharomyces pombe
An14g04980	Complex: PRP19 of S. cerevisiae is a component of the spliceosome, the multiprotein complex responsible for pre-mRNA splicing; within the complex, PRP19 itself is in an oligomeric form.; Function: PRP19 of S. cerevisiae is also involved in an error-prone repair pathway which relies on a recombinational mechanism, comparable to the E. coli SOS repair pathway.; Phenotype: S. cerevisiae null mutant for PRP19 is inviable,other allelic variants are sensitive to DNA mutagens, unable to perform induced mitotic recombination and sporulation.; Remark: PRP19 of S. cerevisiae is also known as PSO4 or YLL036C.; Title: strong similarity to splicing protein Prp19 -Saccharomyces cerevisiae; nucleus; See PMID 7680101; See PMID 8194532; See PMID 8441419; See PMID 2671661; See PMID 2671705
An14g04990	Similarity: the similarity to fkbp39 of D. melanogaster is mainly due to the acidic region present in the fly protein.; Title: weak similarity to FK506-binding 39k protein fkbp39 - Drosophila melanogaster; See PMID 7538962
An14g05000	Function: Ria1 of S. cerevisiae is involved in the biogenesis of the 60S subunit of the ribosome.; Remark: Ria1 of S. cerevisiae is also known as YNL163C.; Remark: reference is: Becam, A-M, Nasr, F, Racki, WJ, Zagulski, M, Herbert, CJ (2001) Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in S. cerevisiae. Mol. Gen. Genet., in press.; Similarity: nevertheless the stronger similarity to Ria1, which characterization was submitted for publication,suggests that the function of the predicted ORF could be different.; Similarity: the predicted ORF displays strong similarity to several putative proteins all annotated as translation elongation factor 2; it shares many structural features with this protein family, comprised the GTP-binding domains.; Title: strong similarity to protein Ria1 -Saccharomyces cerevisiae
An14g05010	Complex: CSL4 of S. cerevisiae is an essential component of the exosome, a conserved complex of multiple 3'-to-5' exonucleases required for diverse RNA processing events, such as mRNA degradation and rRNA processing.; Phenotype: null mutation of CSL4 in S. cerevisiae is lethal.; Remark: CSL4 of S. cerevisiae is also known as SKI4 or YNL232W.; Similarity: the N-terminal part of the predicted ORF has only marignal similarity to CSL4 of S. cerevisiae.; Similarity: the predicted ORF shows stronger similarity to putative proteins found in yeasts, fungi and mammals.; Title: strong similarity to 3-5 exoribonuclease Csl4 - Saccharomyces cerevisiae; See PMID 9583939; See PMID 10087930; See PMID 11027292
An14g05020	Complex: Vac8 of S. cerevisiae interacts with Apg13.; Function: VAC8 of S. cerevisiae functions in both vacuole inheritance between mother and daughter cells, and protein targeting from the cytoplasm to vacuole.; Localization: VAC8 of S. cerevisiae is found on the vacuole membrane.; Similarity: armadillo (Arm) repeats are thought to mediate protein-protein interactions, and many Arm proteins have multiple functions.; Title: strong similarity to armadillo repeat-containing protein Vac8 - Saccharomyces cerevisiae; vacuole; See PMID 9490720; See PMID 9664035; See PMID 10837477; See PMID 10873824
An14g05030	Title: weak similarity to hypothetical membrane protein SCK20.08 - Streptomyces coelicolor
An14g05050	Function: dma1 of S. pombe is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is impaired.; Similarity: the predicted ORF contains an FHA (Forkhead-associated) domain, which is a phosphopeptide binding motif; the FHA domain is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Similarity: the similarity to dma1 of S. pombe is limited to the C-terminal half of the predicted ORF; the C-terminal half is very rich of low-complexity,serine-containing repeats, producing many alignments with proteophosphoglycans.; Title: strong similarity to defective in mitotic arrest dma1p - Schizosaccharomyces pombe; See PMID 8978687
An14g05070	Title: similarity to hypothetical protein X4G11.070 - Neurospora crassa
An14g05080	Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: closest manual BLASTP homologue: SWISSPROT:ANK1_HUMAN.; Similarity: ankyrin repeats (ANK) are tandemly repeated modules of about 33 amino acids, that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF shows similarity also to the ZU5 domain present in ZO-1 and Unc5-like netrin receptors, which function remains unknown.; Similarity: the similarity to ankyrin of H. sapiens and other proteins is mainly due to the presence of two ankyrin repeats.; Title: weak similarity to ankyrin (variant 2.1) -Homo sapiens; See PMID 1689849
An14g05090	Similarity: BLASTP identifies a stretch of similarity to D. melanogaster genomic fragment CG6456; there is no sufficient reason to consider such a similarity significant.
An14g05100	Title: strong similarity to hypothetical protein alr2987 - Nostoc sp.
An14g05110	Similarity: the predicted ORF contains an EF-hand,the most common domain responsible for calcium binding in proteins like calmodulin, myosin regulatory light chains,parvalbumins, troponins C, and neuronal calcium sensors.; Title: weak similarity to hypothetical protein AT4g01140 - Arabidopsis thaliana
An14g05120	Function: MoxR is a poorly characterized bacterial protein which may be involved in the regulation of formation of active methanol dehydrogenase.; Similarity: the predicted ORF shows weak similarity to many putative proteins classified as MoxR-like ATPases.; Title: strong similarity to hypothetical conserved protein 17E5.290 - Neurospora crassa
An14g05130	Complex: VPS16 of S. cerevisiae is a component of the so called class C Vps complex, required for vacuolar protein sorting and morphology.; Function: VPS16 of S. cerevisiae is required for vacuolar protein sorting and vacuolar biogenesis and stability.; Phenotype: S. cerevisiae VPS16 mutants have pleiotropic defects in vacuolar morphology and vacuolar protein targeting.; Title: strong similarity to vacuolar protein sorting-associated protein Vps16 - Saccharomyces cerevisiae; vacuole; See PMID 3062374; See PMID 8444873; See PMID 9362071; See PMID 1526998
An14g05140	Phenotype: ECM1 mutation in S. cerevisiae causes perturbation of the cell surface.; Remark: ECM1 of S. cerevisiae is also called YAL059w.; Title: similarity to Ecm1 - Saccharomyces cerevisiae; See PMID 9335584
An14g05150	Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + thiol.; Function: UBP1 of S. cerevisiae has an ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an amino-terminal extension to ubiquitin.; Similarity: UBP1 belongs to peptidase family C19; also known as family 2 of ubiquitin carboxyl-terminal hydrolases.; Similarity: although the predicted ORF is shorter than UBP1 of S. cerevisiae and the alignment contains several gaps, it shows consistent similarity to several ubiquitin-specific processing proteases.; Title: similarity to ubiquitin specific protease Ubp1 - Saccharomyces cerevisiae; See PMID 2050695; See PMID 8982460; See PMID 1429680; See PMID 10527495
An14g05160	Function: centrin is a ubiquitous component of centrosomes and mitotic spindle poles of diverse organisms and plays a role in centrosome separation at the time of mitosis.; Localization: human centrin is localized at the centrosome of interphase cells and redistributes to the region of the spindle poles during mitosis.; Similarity: in the predicted ORF the EF-hands are not well conserved; this fact might have important functional consequences.; Similarity: the human centrin sequence has four putative calcium-binding domains as defined by the EF-hand consensus.; Title: similarity to centrin - Homo sapiens; centrosome; See PMID 8175926
An14g05170	Function: thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide, and catalyzes dithiol-disulfide exchange reactions.; Similarity: the main feature of the predicted ORF,as well as of the very similar N. crassa hypothetical protein 17E5. 270, is to contain different structural domains, including the thioredoxin and the leucine zippers in the C-terminal region.; Similarity: the similarity to chicken thioredoxin and similar proteins of other species is limited to a single domain of the predicted ORF.; Title: similarity to thioredoxin - Gallus gallus; See PMID 2838473
An14g05180	Title: weak similarity to hypothetical As-rel1 -Halocynthia roretzi
An14g05190	Title: weak similarity to MLL - Fugu rubripes; See PMID 9681821
An14g05200	Title: questionable ORF
An14g05210	Title: weak similarity to protein fragment SEQ ID NO:24290 from patent EP1033405-A2 - Arabidopsis thaliana
An14g05220	Title: weak similarity to furin-like protein 1 Fur1 - Drosophila melanogaster; See PMID 8491178
An14g05240	Title: questionable ORF
An14g05250	Function: it is suggested that the ORFL15 protein of S. spinosa is involved in oxido-reduction during spinosyn biosynthesis.; Remark: Spinosyns are insecticidal microlides which are useful for the control of arachnids, nematodes and insects.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: strong similarity to protein involved in spinosyn biosynthesis ORFL15 from patent WO9946387-A1 -Saccharopolyspora spinosa
An14g05260	Catalytic activity: ATP + L-cysteine + tRNA(cys) = AMP + pyrophosphate + L-cysteinyl-tRNA(cys).; Similarity: YNL247W of S. cerevisiae belongs to class-I aminoacyl-tRNA synthetase family.; Title: strong similarity to cysteine--tRNA ligase YNL247w - Saccharomyces cerevisiae; See PMID 7619074; See PMID 9523015; See PMID 11347887
An14g05290	Function: isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: isp4 of S. pombe was originally identified by subtractive screening as gene induced during the sexual differentiation process.; Similarity: the predicted A. niger protein shows strong similarity to protein isp4 of S. pombe, which belongs to the OPT subfamily of transporters specific for small oligopeptides (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe; plasma membrane; See PMID 7954893; See PMID 9643541
An14g05300	Complex: YRA1 of S. cerevisiae mediates nuclear export of mRNA by interacting with several other protein factors, like Mex67.; Function: YRA1 of S. cerevisiae is an mRNA-binding protein involved in the nuclear export of mRNA towards the cytoplasm.; Remark: although the gene structure looks strange,the strong similarity to known proteins justify the model.; Similarity: YRA1 S. cerevisiae belongs to the evolutionarily conserved REF (RNA and export factor binding proteins) family of hnRNP-like proteins.; Title: strong similarity to RNA annealing protein Yra1 - Saccharomyces cerevisiae; nucleus; See PMID 9149233; See PMID 10783248; See PMID 10786854; See PMID 11390651
An14g05310	Function: the S. cerevisiae homolog Did3p is a class E Vps factor, which function in the maturation of a late endosome/prevacuolar compartment into multivesicular bodies that then fuse with the vacuole.; Remark: DID3 of S. cerevisiae is also called YKL041w.; Remark: S. cerevisiae Did3p is probably involved in the ubiquitin-mediated maturation of multivesicular bodies.; Title: strong similarity to protein involved in vacuolar protein sorting Did3 - Saccharomyces cerevisiae; endosome; See PMID 9606181; See PMID 11029042
An14g05320	Function: WOS2 of S. pombe is a cochaperone protein that interacts with cdc2 in the control of the M-G1 transition.; Similarity: WOS2 of S. pombe belongs to the p23 / wos2 family.; Title: strong similarity to cell cycle regulator p21 protein wos2p - Schizosaccharomyces pombe; See PMID 10581266
An14g05330	Title: strong similarity to hypothetical protein YOR091w - Saccharomyces cerevisiae
An14g05340	Title: strong similarity to hypothetical protein BH0485 - Bacillus halodurans
An14g05350	Function: ayg1 of A. fumigatus has an unknown function, but it is contained in the gene cluster responsible for conidial pigmentation.; Phenotype: ayg1 null mutants of A. fumigatus have yellowish-green conidia.; Title: strong similarity to hypothetical yellowish-green 1 ayg1 - Aspergillus fumigatus; See PMID 10515939
An14g05370	Similarity: the predicted ORF shows very strong similarity to abr1 of A. fumigatus, a gene of the conidial pigmentation gene cluster; abr1 mutants have brown conidia,and the proposed function of abr1 is multicopper oxidase.; Title: strong similarity to cell surface ferroxidase precursor Fet3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8599111; See PMID 9162052; See PMID 9325307; See PMID 9520490; See PMID 10515939
An14g05380	Catalytic activity: the D-amino acid oxidase catalyzes the reaction: D-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2.; Catalytic activity: the D-amino acid oxidase has a wide specificity for D-amino acids, acting also on glycine.; Cofactor: D-amino acid oxidase is a flavoprotein (FAD is the cofactor).; Title: strong similarity to D-amino acid oxidase DAO1 - Trigonopsis variabilis; See PMID 9434346
An14g05390	Title: strong similarity to hypothetical protein CGI-35 - Homo sapiens
An14g05400	Title: weak similarity to proteinase inhibitor PID -Solanum tuberosum; See PMID 8069493
An14g05410	Similarity: A. niger EST EMBLEST:BE760323 corresponds to the 3' portion of the last exon and a fragment of the putative 3'-UTR of the gene.; Title: strong similarity to hypothetical protein CAD21189.1 - Neurospora crassa
An14g05420	Title: weak similarity to hypothetical Ena-VASP-like protein - Homo sapiens
An14g05430	Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: similarity to meso-2,3-butanediol dehydrogenase (D-acetoin forming) budC - Klebsiella pneumoniae; See PMID 10389264; See PMID 11169050; See PMID 11173520; See PMID 11375507
An14g05440	Title: strong similarity to hypothetical protein encoded by An11g07600 - Aspergillus niger
An14g05450	Title: strong similarity to hypothetical protein encoded by An08g11330 - Aspergillus niger
An14g05460	Title: similarity to hypothetical protein YHR040w -Saccharomyces cerevisiae
An14g05470	Function: enterophilins are a new family of proteins with unknown function associated with enterocyte differentiation in C. porcellus.; Title: weak similarity to hypothetical enterophilin-2L - Cavia porcellus; See PMID 11278568
An14g05490	Title: weak similarity to precursor of licheninase -Bacillus polymyxa; See PMID 1938968
An14g05500	Similarity: the BLASTP alignment is very nice, but limited to the C-terminal part of the predicted ORF.; Title: similarity to axin-associating molecule Axam - Rattus norvegicus; See PMID 10944533
An14g05510	Function: YSR3 of S. cerevisiae is involved in regulating ceramide and phosphorylated sphingoid base levels, and modulates stress responses through sphingolipid metabolites.; Remark: YSR3 of S. cerevisiae is also called YKR053c.; Similarity: A. niger EST EMBLEST:BE760128 comprises part of the putative 5'-UTR of the gene and part of exon 1.; Title: strong similarity to dihydrosphingosine-1-phosphate phosphatase Ysr3 -Saccharomyces cerevisiae; See PMID 9041652; See PMID 9195906; See PMID 9353337; See PMID 9419344
An14g05520	Title: questionable ORF
An14g05530	Remark: RHO1 gene encodes a low-molecular-weight GTPase. one of its recently identified functions is the regulation of beta-1,3-glucan synthase, which synthesizes the main component of the fungal cell wall.; Similarity: belongs to the ras transforming proteins.; Title: strong similarity to GTP-binding protein rho1 from patent WO9738129-A1 - Candida sp.; See PMID 9401032
An14g05540	Title: similarity to essential protein #328 from patent WO200286090-A2 - Aspergillus fumigatus
An14g05550	Remark: this ORF is a putative alginate lyase by homology.; Similarity: belongs to the NADPH:quinone reductase and related Zn-dependent oxidoreductases.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities.; Title: strong similarity to protein from patent WO0100844-A - Corynebacterium glutamicum
An14g05570	Title: similarity to EST an_3478 - Aspergillus niger
An14g05590	Remark: similarity to human sequence 203 from patent WO0129221-A/203.; Remark: this ORF represemnts a putative DNA repair protein.; Title: similarity to sequence 203 from patent WO0129221-A - Homo sapiens
An14g05600	Title: similarity to hypothetical D-alanine-D-alanine ligase B - Aquifex aeolicus
An14g05610	Title: questionable ORF
An14g05620	Title: similarity to EST an_2924 - Aspergillus niger
An14g05630	Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: the phenylpropanoid enzyme 4-coumarate:coenzyme A ligase (4CL) plays a key role in general phenylpropanoid metabolism. 4CL is related to a larger class of prokaryotic and eukaryotic adenylate-forming enzymes and shares several conserved peptide motifs with these enzymes.; Similarity: belongs to the Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.; Title: strong similarity to 4-coumarate-CoA ligase 3 4CL3 - Populus balsamifera; See PMID 11405227
An14g05660	Title: questionable ORF
An14g05670	Remark: the Japanese pear pathotype of Alternaria alternata produces host-specific AK-toxin and causes black spot of Japanese pear. Transformation of the wild type with AKTR-1- and AKT3-1-targeting vectors produced toxin-deficient (Tox-), nonpathogenic mutants.; Title: similarity to AK-toxin regulating protein AktR-1 - Alternaria alternata; See PMID 10975654
An14g05690	Title: questionable ORF
An14g05700	Title: strong similarity to hypothetical protein encoded by An01g10130 - Aspergillus niger
An14g05710	Similarity: although the similarity to Rhp16 of S. pombe is weak, some motifs in the predicted ORF suggest that it might be involved in DNA binding and repair.; Title: weak similarity to RAD16 nucleotide excision repair protein homolog rhp16p - Schizosaccharomyces pombe; See PMID 8879272; See PMID 10446227
An14g05730	Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the length of the predicted ORF is only one half of the M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An14g05750	Catalytic activity: OPR3 of A. thaliana catalyzes the reaction: 8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP+ = (15Z)-12-Oxophyto-10,15-dienoate + NADPH.; Phenotype: A. thaliana ORP3 null mutants are male-sterile due to defects in pollen release caused by a delay in the stomium degeneration program.; Remark: Jasmonic acid (JA) and its precursor 12-oxophytodienoic acid (OPDA) act as plant growth regulators and mediate responses to environmental cues.; Title: strong similarity to 12-oxo-phytodienoate reductase OPR3 - Arabidopsis thaliana; See PMID 10899973; See PMID 10973494
An14g05760	Catalytic activity: chnA of Acinetobacter catalyzes the reaction: Cyclohexanol + NAD+ <=> Cyclohexanone + NADH.; Similarity: the gene model structure is confirmed by A. niger EST EMBLEST:BE759160, which covers exons 1 to 3.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013
An14g05765	Title: strong similarity to EST an_3120 -Aspergillus niger
An14g05780	Function: the S. cerevisiae ERG4 gene encodes sterol C-24(28) reductase which catalyzes the final step in the biosynthesis of ergosterol.; Remark: ergosterol is the precursor of vitamin D2.; Title: strong similarity to sterol C-24 reductase Erg4 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7791529; See PMID 8125337; See PMID 9630650; See PMID 10722850; See PMID 1882553
An14g05790	Similarity: the predicted protein shows similarity to several putative and described fungal transcription factors; their common feature is the presence of a typical binuclear cluster zinc-finger, responsible for DNA binding,which is not well conserved in the predicted protein.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360
An14g05800	Function: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.; Gene-ID: aguA; See PMID 10376490
An14g05810	Complex: GCN5 of S. cerevisiae is a component of the SAGA complex, which posseses histone acetylation function and is important for transcription in vivo.; Function: GCN5 of S. cerevisiae and many other organisms acetylates histones H3 and H4 non-randomly at specific lysines, causing chromatin remodelling during transcriptional activation.; Similarity: in the C-terminal part of the protein there is a bromodomain, which function may be to tether type A histone acetyltransferase to the chromatin during gene activation.; Title: strong similarity to histone acetyltransferase Gcn5 - Saccharomyces cerevisiae; nucleus; See PMID 7862114; See PMID 7957049; See PMID 8601304; See PMID 8805705; See PMID 8943299
An14g05820	Catalytic activity: hydrolysis of terminal,non-reducing beta-d-galactose residues in beta-d-galactosides.; Function: cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.; Remark: beta-galactosidase of A. niger has been already patented under patentnumber WO9010703 and WO9716555-A1.; Similarity: belongs to family 35 of glycosyl hydrolases.; Similarity: the absence of nice BLASTN alignments,demonstrates that the predicted ORF is just an homologue of the already described beta-galactosidase of A. niger.; Title: strong similarity to beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 1368193
An14g05830	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the similarity to het-e1 involves only the N-terminal half of the predicted protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123
An14g05840	Catalytic activity: A. flavus omtB converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: A. flavus omtB is a demethylsterigmatocystin 6-O-methyltransferase involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10806361
An14g05850	Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the similarity to PTH11 of M. grisea is limited to the N-terminal half of the predicted ORF.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An14g05870	Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the length of the predicted ORF is only one half of the M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An14g05880	Similarity: the central part of the predicted ORF shows only weak similarity to N. crassa B9I2. 20.; Title: strong similarity to hypothetical conserved protein B9I2.20 - Neurospora crassa
An14g05890	Remark: CLA compounds(cis,trans)-9,11-linoleic acid and (trans, cis)-10,12-linoleic acid are recognised nutritional supplements and effective inhibitors of epidermal carcinogenesis and forestomach neoplasia; furthermore CLA has also been shown to prevent adverse effects caused by immune stimulation in chicks, mice and rats, and has been shown to decrease the ratio of low density lipoprotein cholesterol to high density lipoprotein cholesterol.; Remark: the linoleate isomerase is used in a method for producing conjugated linoleic/linolenic acid (CLA) from oils such as sunflower oil, safflower oil, corn oil,linseed oil, etc.; Similarity: the N-terminal part of the prediction ORF shows also weak similarity to some oxidoreductases.; Similarity: the patented protein, as well as the predicted ORF, show strong similarity to the 67 kDa myosin-crossreactive streptococcal antigen of Streptococcus pyogenes, a protein with unknown function, but involved in the pathogenesis of streptococcal infections.; Title: strong similarity to linoleate isomerase protein sequence PCLA591 from patent WO9932604-A1 -Lactobacillus reuteri; See PMID 8188369
An14g05900	Similarity: other BLASTP hits are explained by the relatively high content of low-complexity regions.; Title: strong similarity to hypothetical protein B14D6.80 - Neurospora crassa
An14g05910	Function: ALG2 of S. cerevisiae is involved in N-glycosylation, converting man[2]glcnac-pp-dolichol to man[3]glcnac-pp-dolichol.; Title: strong similarity to mannosyltransferase Alg2 - Saccharomyces cerevisiae; See PMID 2660743; See PMID 8400550
An14g05920	Function: kinesins are microtubule-dependent motor proteins, involved in organelle transport, in mitosis and meiosis, and in the transport of synaptic vesicles along axons of animal neurons.; Similarity: the closest homologues, comprising XCENP-E of X. laevis, are involved in driving congression of chromosomes to the metaphase plate.; Similarity: the main feature of the predicted ORF is to contain, in the N-terminal half, several kinesin-like domains, explaining the strong similarity to several different kinesin-like proteins.; Similarity: the predicted ORF has just half of the length of XCENP-E of X. laevis; the best homologue, having also a corresponding length, is a N. crassa hypothetical protein.; Title: strong similarity to kinesin-related protein XCENP-E - Xenopus laevis; See PMID 9363944
An14g05930	Similarity: the similarity to NAB2 of M. musculus is weak, and the gene structure of the predicted ORF is questionable.; Title: weak similarity to NGFI-A binding protein 2 NAB2 - Mus musculus; See PMID 7624335; See PMID 8668170
An14g05940	Similarity: very weak similarity to a fragment of protein SEQ ID NO:917 of patent n. WO200042171-A1 of Eucalyptus grandis.; Title: questionable ORF
An14g05950	Similarity: a short stretch of amino acids of the predicted ORF shows some weak similarity to an A. thaliana hypothetical protein.
An14g05960	Catalytic activity: H2O + agmatine <=> urea + putrescine.; Complex: agmatinase of E. coli is a homodimer of the speB gene product.; Function: agmatinase of E. coli is part of the second putrescine biosynthetic pathway; it also represents the only pathway for urea biosynthesis in E. coli as no urease is present.; Similarity: the predicted ORF shows much stronger similarity to putative agmatinases of N. crassa and S. pombe.; Title: strong similarity to agmatinase speB -Escherichia coli; See PMID 2153656; See PMID 1310091
An14g05970	Title: strong similarity to hypothetical protein SPAC11D3.06 - Schizosaccharomyces pombe
An14g05980	Function: TPO3 of S. cerevisiae is a vacuolar polyamine transporter, that controlls the cytoplasmic spermine content.; Phenotype: S. cerevisiae cells in which TPO3 was disrupted showed an increased sensitivity to polyamine toxicity and a decrease in polyamine uptake activity and polyamine content in vacuoles.; Phenotype: S. cerevisiae cells overexpressing TPO3 were resistant to polyamine toxicity and showed an increase in polyamine uptake activity and polyamine content in vacuoles.; Remark: TPO3 of S. cerevisiae is also called YPR156c or P9584. 7.; Similarity: the predicted ORF is 125 amino acids longer at the N-terminus than TPO3 of S. cerevisiae.; Title: strong similarity to polyamine transport protein Tpo3 - Saccharomyces cerevisiae
An14g05990	Title: weak similarity to spindle pole body-associated protein sad1p - Schizosaccharomyces pombe
An14g06000	Function: MDV1 of S. cerevisiae is involved in the mitochondrial membrane fission event by regulating the assembly of Dnm1p, a dynamin-related GTPase, into punctate structures at the outer mitochondrial membrane.; Phenotype: the mitochondrial fission is blocked in S. cerevisiae MDV null mutants and mitochondrial membranes form nets.; Remark: is also called YJL112w, NET2, FIS2 or GAG3.; Title: strong similarity to mitochondrial fission protein Mdv1 - Saccharomyces cerevisiae; See PMID 11038182; See PMID 11038183
An14g06010	Catalytic activity: chorismate mutases convert chorismate <=> prephenate.; Function: aroC of A. nidulans is an allosterically regulated chorismate mutase acting at the first branch point of aromatic amino acid biosynthesis to generate prephenate.; Induction: tryptophan acts as heterotropic activator of aroC from A. nidulans.; Repression: tyrosine act as negative acting,heterotropic feedback-inhibitor of aroC from A. nidulans.; Title: strong similarity to chorismate mutase aroC -Aspergillus nidulans; cytoplasm; See PMID 10428795
An14g06020	Similarity: the ORF shows similarity to putative cdk inhibotor p21 binding protein TOK-1 of H. sapiens.; Title: strong similarity to hypothetical cdk inhibitor p21 binding protein SPCC613.08 -Schizosaccharomyces pombe
An14g06030	Remark: the predicted ORF is only 45 amino acids long.
An14g06040	Similarity: the predcited ORF is 96 amino acids longer at the N-terminus than the hypothetical protein SPBC17D11. 03c of S. pombe.; Title: weak similarity to hypothetical protein SPBC17D11.03c - Schizosaccharomyces pombe
An14g06050	Title: weak similarity to hypothetical protein B10H18.060 - Neurospora crassa
An14g06060	Function: TTP1 of S. cerevisiae is involved in the transfer of mannose residues to the mannans of glycoproteins during maturation in the Golgi.; Function: the correct mannosylation of proteins by TTP1 of S. cerevisiae is essential for growth and morphogenesis.; Golgi; Phenotype: the N-linked sugar residues in the S. cerevisiae TTP1 null mutant lack the main alpha-1,2-linked branches of the mannan.; Remark: TTP1 of S. cerevisiae is also called mnn2 or YBR015C.; Title: strong similarity to alpha-1,2-mannosyltransferase Ttp1 - Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928; See PMID 9878809
An14g06070	Title: similarity to hypothetical protein CAD11325.1 - Neurospora crassa
An14g06100	Title: strong similarity to hypothetical protein BAC71605.1 - Streptomyces avermitilis
An14g06110	Title: weak similarity to gene expression regulator At221 from patent WO200257456-A2 - Unclassified organism
An14g06130	Remark: the predicted protein sequence of the ORF contains a poly-asparagine stretch, that shows unspecific homology to several asparagine-rich proteins.; Title: strong similarity to hypothetical protein encoded by An06g01430 - Aspergillus niger
An14g06140	Title: strong similarity to hypothetical protein encoded by An14g07070 - Aspergillus niger
An14g06150	Function: the insecticidal toxin of P. luminescens has activity against Lepidopteran insects such as Cabbage Looper (Trichoplusia ni), European Corn Borer (Ostrinia nubialis) and Fall Armyworm (Spodoptera frugiperda) and also against Coleopteran insects (e. g., Colorado Potato Beetle, Leptinotarsa decimlineata).; Similarity: the ORF shows similarity to the probable nematicidal protein 2 xnp2 of X. bovienii, which is believed to mediate cell lysis in nematodes.; Title: strong similarity to insecticidal toxin from patent WO9942589-A2 - Photorhabdus luminescens; See PMID 11375158
An14g06160	Title: strong similarity to hypothetical protein encoded by An08g09580 - Aspergillus niger
An14g06170	Remark: alignment of A. niger ESTs with similarity to the predicted protein indicates alternative splicing.; Similarity: additionally, the ORF shows similarity to similarity to EST an_3586 (EMBLEST:BE759248) of Aspergillus niger.; Title: similarity to hypothetical protein AAK62875.1 - Microscilla sp.
An14g06180	Function: KIF1A of H. sapiens is a motor protein for the anterograde axonal transport of synaptic vesicles by using the hydrolysis of ATP to generate force and movement along their cellular tracks, the microtubules.; Remark: KIF1A of H. sapiens is also called ATSV.; Similarity: the ORF show similarity to the N-terminal region of KIF1A from H. sapiens, which does not include the FHA domain, that is a putative nuclear signalling domain and the 'pleckstrin homology' (PH) domain, which is a domain that occurs in a wide range of proteins involved in intracellular signaling, but the region inculdes the motor domain.; Title: strong similarity to kinesin motor protein KIF1A - Homo sapiens; See PMID 10660047; See PMID 11163129; See PMID 7539720
An14g06190	Remark: alternative splicing for murine proteins described.; Similarity: shows only partial similarity to protein of S. cerevisiae.; Similarity: shows stronger similarity to undescribed translation initiation factors of several species.; Title: similarity to translation initiation factor eIF2B 71 kDa delta subunit Gcd2 - Saccharomyces cerevisiae; cytoplasm; See PMID 9472020; See PMID 2038326
An14g06200	Complex: DNA polymerase alpha in a complex with DNA primase is a replicative polymerase.; Function: POL12 is involved in stimulation of formation of Holliday junctions.; Function: POL12 is required for initiation of DNA replication at a stage before the hydroxyurea step.; Title: strong similarity to DNA-directed DNA polymerase alpha 70 KD subunit Pol12 - Saccharomyces cerevisiae; nucleus; See PMID 9230305
An14g06210	Function: PDR16 and PDR17 control levels of various lipids in various compartments of the cell and thereby provide a mechanism for multidrug resistance unrecognized so far.; Function: deletion of PDR16 resulted in hypersensitivity of yeast to azole inhibitors of ergosterol biosynthesis.; Title: strong similarity to protein involved in lipid biosynthesis and multidrug resistance Pdr16 -Saccharomyces cerevisiae; See PMID 9890948
An14g06220	Function: patented protein SNF4 is involved in carbon catabolite repression in plants and seeds.; Similarity: shows also strong similarity to regulatory protein SNF4 of S. cerevisiae.; Title: strong similarity to sucrose non-fermenting 4 protein SNF4 from patent WO200036116-A2 - Glycine max; nucleus
An14g06230	Similarity: hypothetical protein of S. aureus is similar to streptococcal hemagglutinin protein.; Similarity: shows only partial similarity to proteins containing high content of repetitive sequences.; Title: weak similarity to hypothetical protein CAE76144.1 - Neurospora crassa
An14g06240	Function: PEK phosphorylates eukaryotic translation initiation factor-2 alpha.; Function: the present sequence of R. spec. encodes a pancreatic eukaryotic translation initiation factor-2 alpha kinase (PEK).; Similarity: shows only partial similarity to hypothetical proteins and to PEK.; Title: weak similarity to eukaryotic translation initiation factor-2 alpha kinase PEK from patent WO9938994-A1 - Rattus sp.
An14g06250	Similarity: similarity to S. pombe transcription factor is restricted to middle part and carboxyterminus.; Title: weak similarity to transcription factor atf21p - Schizosaccharomyces pombe; nucleus; See PMID 10102365; See PMID 8824587
An14g06260	Function: QUTD is a quinate permease.; Function: belongs to the superfamily of maltose transport protein MAL61.; Similarity: similarity to quinate transport proteins resticted to middle part and carboxyterminus.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2976880
An14g06270	Similarity: shows only partial similarity to proteins containing Zn(2)-Cys(6) zinc-finger domains.; Title: weak similarity to negative acting factor naf - Nectria haematococca; nucleus; See PMID 9139694
An14g06280	Function: IREG1 is a basolateral membrane protein involved in iron transport from the intestine to the circulation; highly expressed in duodenal mucosa and placenta.; Title: strong similarity to iron-regulated transporter IREG1 - Mus musculus; plasma membrane; See PMID 10882071
An14g06290	Function: Human 3-hydroxyisobutyryl-coenzyme A hydrolase (HIB- CoA hydrolase) can be used for treating,preventing and diagnosing disorders associated with cellular accumulation of methacrylyl-CoA.; Function: such disorders include metabolic disorders such as methacrylic aciduria, congenital defects such as cardiac abnormalities, neurological abnormalities,musculoskeletal and connective tissue abnormalities and other instances of cellular damage.; Similarity: shows also strong similarity to probable enoyl-CoA-hydratase of S. pombe and N. crassa.; Title: strong similarity to 3-hydroxyisobutyryl-coenzyme A hydrolase from patent WO9851782-A2 - Homo sapiens
An14g06300	Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368
An14g06310	Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml35 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368
An14g06320	EC:3.4.99.36; Function: IMP1 catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.; Function: IMP1 cleaves after Mas1p and Mas2p in the matrix have cleaved the transit peptide to expose the signal for re-export.; Function: IMP1 is required for respiratory function.; Function: IMP1 removes inner membrane space (IMS) targeting peptides for Cyb2p and Cox2p but not for Cyt1p.; Title: strong similarity to mitochondrial protease Imp1 - Saccharomyces cerevisiae; localisation:mitochondrion
An14g06330	Function: the patented sequence may be useful in the control of gene expression as a promoter, coding sequence,3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome, as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Function: the protein it encodes may have a use in protein identification and in the elucidation of signal transduction and metabolic pathways.; Similarity: shows stronger similarity to hypothetical proteins of A. thaliana and O. sativa.; Title: similarity to protein fragment SEQ ID NO:498 from patent EP1033405-A2 - Arabidopsis thaliana
An14g06340	Function: RSP29, a protein secreted by rat round spermatids, stimulates the secretory function of Sertoli cells in the testis.; Function: the enzyme of R. norvegicus plays a regulatory role in spermatogenesis.; Similarity: shows also similarity to fungal hydroxyacylglutathione hydrolases that function in aminoacid degradation. .; Title: strong similarity to hydroxyacylglutathione hydrolase RSP29 - Rattus norvegicus
An14g06350	Function: LAS1 might play a role in regulating bud formation and morphogenesis via the expression of components that function directly in these processes.; Similarity: shows stronger similarity to undescribed proteins of N. crassa and S. pombe.; Title: similarity to nuclear protein Las1 -Saccharomyces cerevisiae; nucleus; See PMID 8582632
An14g06360	Similarity: shows also similarity to cDNA clone 0386 3' an_0386 of A. niger.; Title: similarity to hypothetical protein 93G11.280 - Neurospora crassa
An14g06380	Similarity: shows only partial similarity to hypothetical proteins with high content of repetitive sequences.; Title: weak similarity to hypothetical protein MT0291.4 - Mycobacterium tuberculosis
An14g06390	Function: protein inta6 described in Herlevsen M. C. Thesis (2001).; Similarity: shows only partial similarity to integrin alpha 6 subchain inta6 of R. norvegicus.; Title: weak similarity to integrin alpha 6 subchain inta6 - Rattus norvegicus
An14g06430	Function: S. cerevisiae ferrireductase system might be a multicomponent electron-transport chain.; Function: protein of S. cerevisiae is involved in ferric reduction.; Title: strong similarity to protein associated with ferric reductase activity Utr1 - Saccharomyces cerevisiae; See PMID 8662826
An14g06440	Remark: function of proteins is not specified in the abstract of the patent.; Similarity: shows also strong similarity to homolog to yeast BET3 involved in targeting and fusion of ER to Golgi transport vesicles of S. pombe.; Title: strong similarity to protein of sequence 1 from patent WO0075305 - Candida albicans; endoplasmatic reticulum
An14g06450	Title: similarity to hypothetical human microfibrillar-associated protein 1 homolog SPAC1782.03 -Schizosaccharomyces pombe
An14g06460	Title: similarity to hypothetical protein CAD70946.1 - Neurospora crassa
An14g06470	Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759883) an_2819.; Similarity: the predicted ORF probably contains intron sequences, as the ORF is around 400 amino acids longer than the putatibe S. pombe protein SPCC4F11. 01.; Title: similarity to hypothetical transcription regulator SPCC4F11.01 - Schizosaccharomyces pombe
An14g06480	Protein sequence is in conflict with the conceptual translation; Function: SMD2 of S. cerevisiae is a component of the spliceosomal U1 small nuclear ribonucleoprotein complex; it is required for pre-mRNA splicing and for snRNP biogenesis.; Remark: a putative sequencing error results in a point mutation.; Remark: the systematic name for SMD2 of S. cerevisiae is YLR275W.; Title: strong similarity to small nuclear ribonucleoprotein Smd2 - Saccharomyces cerevisiae [putative sequencing error]; nucleus; putative sequencing error
An14g06490	Remark: the ORF is only 30 amino acids long and contains a relatively long intron.; Title: questionable ORF
An14g06500	Catalytic activity: glycerone kinases catalyse ATP + glycerone <=> ADP + glycerone phosphate.; Induction: DAK1 of S. pombe displayed a halometric increase in the amount of transcript, when cells were grown under high NaCl concentrations.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759040) an_3324.; Title: strong similarity to glycerone kinase isoform I dak1p - Schizosaccharomyces pombe; See PMID 9038161
An14g06510	Remark: the ORF contains relatively long introns.
An14g06520	Function: CUL-4A of H. sapiens is a member of the cullin/Cdc53 family of proteins, which are believed to function as an essential component of a multifunctional Ub-protein ligase E3 complex that has a critical role in Ub-mediated proteolysis.; Function: CUL-4A of H. sapiens is found in a complex with UV-damaged DNA-binding DDB, which is believed to be involved in DNA repair, suggesting a role for CUL-4A in cell cycle control, as found for other cullins.; Induction: human cul-4 gene is amplified and overexpressed in primary breast cancers.; Title: strong similarity to ubiquitin protein ligase CUL4A - Homo sapiens; See PMID 9721878; See PMID 10585395
An14g06530	Function: NUP192 of S. cerevisiae is a large yeast nucleoporin involved in mRNA export.; Remark: the systematic name for NUP192 of S. cerevisiae is YJL039C.; Similarity: the ORF and NUP192 of S. cerevisiae show local similarity (N-terminally).; Similarity: the S. pombe protein SPCC290. 03c shows strong similarity to the ORF.; Title: similarity to nucleoporin Nup192 -Saccharomyces cerevisiae; nucleus; See PMID 10428845
An14g06540	Function: TEL1 of S. cerevisiae is a member of the ATM family of genes involved in telomere length regulation.; Phenotype: the S. cerevisiae tel1rad3 double mutant grew poorly and formed irregular-shaped colonies, probably due to chromosome instability, however, during prolonged culture of the double mutant, cells forming normal round-shaped colonies arose at a relatively high frequency.; Phenotype: the S. cerevisiae tel1rad3 double mutant showed all three chromosomes in circular from, which lacked telomeric sequences.; Similarity: the similarity of the ORF to TEL1 of S. cerevisiae starts with amino acid 1782, and includes the catalytic regions of PI-kinases, the FAT and phosphotidylinositol kinase domains.; Title: strong similarity to phosphotidylinositol kinase tel1p - Schizosaccharomyces pombe
An14g06550	Title: strong similarity to hypothetical membrane protein YNL011c - Saccharomyces cerevisiae
An14g06560	Function: the function of yeast gamma DNA-polymerases is restricted to mitochondrial DNA replication and repair.; Similarity: the ORF shows similarity to several DNA polymerases from different species.; Title: strong similarity to DNA-directed DNA polymerase gamma mip1p - Schizosaccharomyces pombe
An14g06570	Function: COP1 of A. thaliana acts as a repressor of photomorphogenesis in darkness, probably as a negative transcription regulator.; Similarity: the C-terminus of the ORF (starting with amino acid 105) shows similarity to the zinc-finger domain of COP1 from several species.; Title: weak similarity to regulator protein COP1 -Arabidopsis thaliana; See PMID 1423630
An14g06580	Similarity: the ORF overlaps with A. niger EST an_1809 (EMBLEST:BE760507).; Similarity: the ORF shows similarity to some hypothetical magnesium/cobalt transporters from bacteria.; Title: similarity to hypothetical magnesium/cobalt transport protein sll0671 - Synechocystis sp.
An14g06590	Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An14g06600	Remark: the predicted ORF is N-terminally truncated due to contig border.
An14g06610	Function: GTPBP1 of H. sapiens is structurally related to elongation factor 1alpha, a key component of protein biosynthesis machinery and is a member of the superfamily characterized by translation elongation factor Tu.; Induction: expression of GTPBP1 of H. sapiens is enhanced by gamma interferon in a monocytic cell line,THP-1.; Remark: GTPBP1 of H. sapiens is also called GTP-BINDING PROTEIN 1, G-PROTEIN 1, GP-1 or GP1.; Similarity: the ORF shows similarity to some translation elongation factors from different species.; Title: strong similarity to GTP-binding protein GTPBP1 - Homo sapiens; See PMID 10938096
An14g06620	Function: SMX4 of S. cerevisiae is, as a component of the snRNP complex, involved in nuclear pre-mRNA splicing; it coprecipitates with U4, U5 and U6 snRNAs.; Remark: SMX4 of S. cerevisiae is also called LSM3 or USS2.; Similarity: the ORF overlaps with A. niger ESTs an_2093 (EMBLEST:BE759322) and an_2787 (EMBLEST:BE759857).; Title: strong similarity to snRNP protein Smx4 -Saccharomyces cerevisiae; nucleus; See PMID 10449419; See PMID 10747033
An14g06640	Catalytic activity: PIGL of R. norvegicus catalyses the N-deacetylation of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI) to form glucosaminyl (GlcN)-PI.; Function: PIGL (phosphatidylinositol glycan class L) of R. norvegicus catalyses the second step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, a membrane ancor for many eukaryotic cell-surface proteins.; Similarity: the ORF overlaps with A. niger EST Nig087 (EMBLEST:AN778).; Title: strong similarity to N-acetylglucosaminyl-phosphatidylinositol deacetylase PIGL - Rattus norvegicus
An14g06650	Remark: the intron-exon structure of the predicted ORF is suboptimal.
An14g06670	Similarity: the predicited ORF is 200 amino acids longer than SPAC1F12. 05 of S. pombe (around 100 amino acids at each end).; Title: strong similarity to hypothetical protein SPAC1F12.05 - Schizosaccharomyces pombe
An14g06680	Title: strong similarity to hypothetical protein F28J12.200 - Arabidopsis thaliana
An14g06690	Remark: the intron-exon structure of the predicted ORF is suboptimal.
An14g06700	Catalytic activity: 4CL1 of N. tabacum converts e. g. ATP + 4-coumarate + CoA <=> AMP + diphosphate + 4-coumaroyl-CoA.; Function: 4CL1 of N. tabacum is involved in the branch-point reactions between general phenylpropanoid metabolism and pathways leading to various specific end products.; Title: strong similarity to 4-coumarate-CoA ligase 4CL1 - Nicotiana tabacum; See PMID 8819324
An14g06710	Remark: the intron-exon structure of the predicted ORF is suboptimal.
An14g06730	Function: rds1 of S. pombe is believed to mediate stress-related responses of the cell.; Induction: of S. pombe rds1 is derepressed when wild-type cells are starved for glucose, ammonium, or phosphate, under carbon dioxide atmosphere, when they are shifted to higher temperatures or when they enter the stationary phase.; Induction: the transcript of rds1 in S. pombe is greatly increased in abundance when adenine auxotrophic strains are starved for adenine.; Title: strong similarity to adenine-repressible gene rds1p - Schizosaccharomyces pombe
An14g06740	Catalytic activity: beta-ketoacyl reductases catalyse (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: beta-ketoacyl reductases are required for the synthesis of the beta-hydroxy acid moiety of rhamnolipids.; Similarity: the ORF shows similarity to various oxidoreductases with different cellular functions.; Similarity: the best homologue of the ORF, B9B15. 60 of N. crassa is a probable NADPH-dependent beta-ketoacyl reductase, which is decribed to be highly similar to rhlG of P. aeruginosa.; Title: strong similarity to beta-ketoacyl reductase rhlG - Pseudomonas aeruginosa
An14g06750	Similarity: . the ORF shows similarity to several oxidoreductases with different cellular functions.; Title: strong similarity to hypothetical oxidoreductase PA0147 - Pseudomonas aeruginosa
An14g06760	Similarity: the ORF shows some similarity to A. niger 2,3-dihydroxybenzoic acid decarboxylase (PATENTPROT:AAW93483).; Title: similarity to hypothetical conserved protein SCIF3.07c - Streptomyces coelicolor
An14g06780	Function: hsp40 of H. sapiens is an abundant chaperone, which can stimulate the ATPase activity of hsp70 and the association between hsc70 and hip.; Remark: hsp40 of H. sapiens is also called DNAJB1,HSPF1, DNAJ1 or HDJ1.; Similarity: the ORF shows strong similarity to J-domains of several DNA-J heat-shock proteins.; Title: strong similarity to heat-shock protein Hsp40 - Homo sapiens; See PMID 10830586
An14g06790	Similarity: the ORF shows similarity to CAF17 of S. cerevisiae, which is predicted to be a CCR4 transcriptional complex component.; Title: strong similarity to hypothetical protein SPAC21E11.07 - Schizosaccharomyces pombe
An14g06800	Function: DCP2 of S. cerevisiae is involved in mRNA degradation in yeast by mRNA decapping.; Remark: DCP2 of S. cerevisiae was also called YNL118C or PSU1, but PSU1 is also taken for a transcription activator protein.; Title: strong similarity to mRNA decapping protein Dcp2 - Saccharomyces cerevisiae; See PMID 10508173; See PMID 11139489
An14g06810	Title: strong similarity to hypothetical protein EAA65239.1 - Aspergillus nidulans
An14g06820	Function: SPBC19C2. 13c of S. pombe is believed to be involved in cytoplasmic ribosome function.; Title: similarity to hypothetical protein SPBC19C2.13c - Schizosaccharomyces pombe
An14g06830	Title: strong similarity to hypothetical membrane protein Ptm1 - Saccharomyces cerevisiae
An14g06850	Remark: WD domains are a characteristic motifs in beta-transducin, the beta1-subunit of the signal-transducing G proteins.; Title: strong similarity to hypothetical WD-repeat protein - Ajellomyces capsulatus
An14g06860	Function: OAC1 of S. cerevisiae is an oxaloacetate carrier, which is responsible for the uptake of oxaloacetate into mitochondria produced from pyruvate by cytoplasmic pyruvate carboxylase.; Phenotype: deletion of the OAC1 gene in S. cerevisiae reduces transport of oxaloacetate sulfate,thiosulfate, and malonate into mitochondria, where as mitochondria from wild-type cells swell in isoosmotic solutions of ammonium salts of oxaloacetate, sulfate,thiosulfate, and malonate, indicating that these anions are cotransported with protons.; Remark: OAC1 of S. cerevisiae is also called YKL120W, YKL522 or PMT1, but PMT1 is also used for an dolichyl-phosphate-mannose--protein mannosyltransferase.; Similarity: the predicted ORF is 78 amino acids longer at the N-termnus than OAC1 of S. cerevisiae.; Title: strong similarity to oxaloacetate transporter Oac1 - Saccharomyces cerevisiae; See PMID 10428783
An14g06870	Catalytic activity: ribonucleotide reductases catalyse 2'deoxyribonucleoside diphosphate + oxidized thioredoxin + H(2)O <=> ribonucleoside diphosphate + reduced thioredoxin.; Function: SUC22 of S. pombe catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides, the first step necessary for DNA synthesis.; Phenotype: disruption SUC22 in S. pombe is lethal.; Remark: SUC22 of S. pombe is also called SPBC25D12. 04.; Title: strong similarity to ribonucleotide reductase suc22p - Schizosaccharomyces pombe; See PMID 8842148
An14g06880	Similarity: the ORF shows strong similarity to several proteins with WD-40 repeat domains.; Similarity: the predicted ORF is 235 amino acids longer at the C-terminus than S. pombe SPAC3H5. 08c.; Title: strong similarity to hypothetical beta-transducin SPAC3H5.08c - Schizosaccharomyces pombe
An14g06890	Remark: QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5. The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Remark: the A. niger ORF contains a putative sequencing error at position 13394.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 2835177; See PMID 2976880
An14g06900	Title: similarity to hypothetical protein encoded by An13g01780 - Aspergillus niger
An14g06910	Catalytic activity: RX+glutathione<=>HX+R-S-glutathione.; Complex: the gluthathione S-transferase III from Zea may forms a homodimer.; Function: the gluthathione S-transferase III from Zea mays conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and is involved in the detoxification of certain herbicides.; Title: similarity to gluthathione S-transferase III GST3 - Zea mays; See PMID 3277162; See PMID 3532034
An14g06920	Title: strong similarity to hypothetical protein 4 -Streptomyces coelicolor
An14g06930	Catalytic activity: ARII of S. salmonicolor catalyzes the reaction of ethyl 4-chloro-3-oxobutanoate (4-COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate.; Similarity: ARII of S. salmonicolor exhibited significant levels of similarity to the amino acid sequences of members of the mammalian 3-hydroxysteroid dehydrogenase-plant dihydroflavonol 4-reductase superfamily but not to the amino acid sequences of members of the aldo-keto reductase superfamily or to the amino acid sequence of an aldehyde reductase previously isolated from the same organism.; Similarity: the A. niger protein also shows similarity to other reductases.; Title: strong similarity to aldehyde reductase II ARII - Sporidiobolus salmonicolor; See PMID 10583966
An14g06940	Remark: the A. niger protein shows weak similarity to several transcription factors and contains a Fungal Zn(2)-Cys(6) binuclear cluster (according to PFAM, PROSITE and BLOCKS).; Title: weak similarity to protein PRIB - Lentinus edodes; nucleus
An14g06950	Function: C. albicans Flu1 is an efflux transporter involved in drug resistance.; Remark: expression of the C. albicans FLU1 gene in S. cerevisiae mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: C. albicans Flu1 is a multidrug efflux transporter gene of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An14g06970	Title: strong similarity to hypothetical protein Rv3762c - Mycobacterium tuberculosis
An14g06980	Catalytic activity: delta-12 fatty acid desaturase of M. alpina catalyzes the desaturation of oleic acid (Delta9-18 : 1) to linoleic acid (Delta9, Delta12 : 2).; Title: strong similarity to delta-12 fatty acid desaturase - Mortierella alpina; See PMID 10215899
An14g07000	Title: similarity to hypothetical protein encoded by An11g09000 - Aspergillus niger
An14g07010	Remark: the A. niger protein shows similarity to many hypothetical reductases and contains a short chain dehydrogenase PFAM domain.; Remark: the patented arabidopsis protein has not been described.; Title: strong similarity to protein fragment SEQ ID NO:61122 from patent EP1033405-A2 - Arabidopsis thaliana
An14g07020	Title: weak similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii
An14g07030	Function: B. subtilis PNB carboxy-esterase catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Similarity: the A. niger protein also shows strong similarity to other ester hydrolases.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An14g07040	Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; nucleus
An14g07050	Function: RTA1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An14g07060	Function: FRM2 of yeast functions in the fatty acid signalling pathway and is itself regulated by fatty acids.; Remark: A better BlastpPATENT hit was not annotated as a clear function could not be identified for it.; Title: strong similarity to fatty acid regulation protein Frm2 - Saccharomyces cerevisiae; See PMID 8701605
An14g07070	Title: similarity to hypothetical hsp70-like protein CAB91447.2 - Neurospora crassa
An14g07080	Title: similarity to hypothetical protein encoded by An14g06130 - Aspergillus niger [putative sequencing error]; putative sequencing error
An14g07090	Title: similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa
An14g07100	Title: strong similarity to hypothetical protein encoded by An09g02660 - Aspergillus niger
An14g07130	Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794
An14g07140	Function: HOC1 of S. cerevisiae is involved in N-glycan processing of proteins, especially cell wall mannoprotein biosynthesis.; Golgi; Phenotype: the S. cerevisiae HOC1 null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered restrictive temperature in a pkc1-371 background.; Remark: the systematic name for HOC1 of S. cerevisiae is YJR075W.; Similarity: the predicted ORF is 83 amino acids shorter at the N-terminus than HOC1 of S. cerevisiae; the homology starts with amino acid 105.; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 9434768
An14g07170	Remark: the intron is unusually long.; Title: questionable ORF
An14g07180	Catalytic activity: alcolhol dehydrogenases catalyse an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Function: alcolhol dehydrogenases are involved in various cellular processes, which require the reversible oxidation of ethanol to acetaldehyde.; Similarity: the ORF shows strong similarity to various alcohol dehydrogenases from several species,especially from bacteria.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 10971204; See PMID 436831; See PMID 1735726
An14g07190	Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa
An14g07200	Catalytic activity: catalases convert 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Function: catC of A. nidulans is involved in the detoxification of hydrogen peroxide, which is a fundamental aspect of the cellular antioxidant responses in amost all aerobically respiring organisms to protect cells.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957
An14g07210	Catalytic activity: hisD of E. coli catalyses L-histidinol + 2 NAD(+) + H(2)O <=> L-histidine + 2 NADH.; Function: hisD of E. coli catalyzes the terminal step in the biosynthesis of histidine, the four-electron oxidation of L-histidinol to histidine.; Remark: hisD of E. coli is also called HDH.; Title: strong similarity to histidinol dehydrogenase hisD - Escherichia coli
An14g07220	Function: the owner of the patent WO200055180-A2 (PATENTPROT:AAB58229) claims, that lung cancer associated proteins and polynucleotide sequences, their agonists, and antagonists may have neuroprotective; cytostatic; cardioactive; immunomodulatory; muscular active general; vulnerary; gastrointestinal general; nephrotropic; antiinfective; gynecological; or antibacterial activity.; Title: similarity to lung cancer associated polypeptide sequence SEQ ID NO:567 from patent WO200055180-A2 - Homo sapiens
An14g07230	Title: similarity to hypothetical protein encoded by An15g00800 - Aspergillus niger
An14g07240	Function: ankyrins attach integral membrane proteins to cytoskeletal elements; they bind to Na-K ATPase and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Similarity: the predicted ORF shows similarity to several ankyrins and ankyrin-like proteins.; Title: similarity to ankyrin Ank2 - Homo sapiens
An14g07260	Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus
An14g07270	Catalytic activity: 1-haloalkane + H(2)O <=> a primary alcohol + halide.; Function: the X. autotrophicus homolog dhmA is an enzyme involved in detoxification of halogenated alkanes,catalyzes cleavage of carbon-halogene bond in halogenated hydrocarbons.; Remark: haloalkane dehalogenases act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.; Similarity: similarity to subfamily of epoxid hydrolases.; Title: similarity to haloalkane dehalogenase dhlA -Xanthobacter autotrophicus
An14g07280	Title: weak similarity to hypothetical protein K07E12.1 - Caenorhabditis elegans
An14g07300	Title: strong similarity to hypothetical protein CAD70322.1 - Neurospora crassa
An14g07310	Remark: the N. crassa homolog B23L21. 350 might be related to the host-specific AK-toxin Akt2.; Title: similarity to hypothetical protein B23L21.350 - Neurospora crassa
An14g07320	Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: Aflatoxin pathway.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus
An14g07330	Title: strong similarity to hypothetical protein ybiU - Escherichia coli
An14g07350	Title: strong similarity to hypothetical protein ybiU - Escherichia coli
An14g07360	Function: the A. parasiticus homolog aflR is a Zn2Cys6-type sequence-specific DNA-binding protein that is thought to be necessary for expression of most of the genes in the aflatoxin pathway gene cluster.; Similarity: the ORF encoded protein shows significant domain homology to binuclear Zn(2)-Cys(6) cluster domains of many fungal transcription factors.; Title: similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus
An14g07370	Title: strong similarity to hypothetical protein EAA60648.1 - Aspergillus nidulans
An14g07380	Similarity: has similarity to superfamily of alcohol dehydrogenases.; Title: strong similarity to hypothetical zinc-binding oxidoreductase BAB49325.1 - Mesorhizobium loti
An14g07390	Catalytic activity: endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans.; Pathway: xylan degradation.; Remark: A. niger XYN1 has a low pH optimum.; Similarity: belongs to cellulase family g (family 11 of glycosyl hydrolases).; Title: strong similarity to endo-1,4-beta-xylanase I xyn1 - Aspergillus niger; extracellular/secretion proteins
An14g07400	Title: strong similarity to hypothetical protein encoded by An14g07410 - Aspergillus niger
An14g07420	Catalytic activity: hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: truncated due to end of contig.; Similarity: belongs to the chitinase family.; Title: strong similarity to chitinase chiC -Aspergillus nidulans [truncated ORF] [putative sequencing error]; putative sequencing error
An01g00010	Remark: 5' truncated ORF due to end of contig.
An01g00020	Function: E. coli PhnN protein is a member of the nucleotide-binding proteins of the binding protein-dependent transport systems.; Remark: blastp shows possibly significant similarity (47% positives) between predicted A. niger protein and E. coli phnN but due to shortness of both peptides the probability is low (p=7,1).; Title: weak similarity to nucleotide binding protein phnN - Escherichia coli
An01g00030	Function: Disruption of S. cerevisiae HGH1 reveals no basic phenotypes.; Remark: S. cerevisiae HGH1 was cloned from cDNA and shows similarity to human non-histone linker DNA-binding proteins of the HMG1 family.; Title: strong similarity to Hgh1 - Saccharomyces cerevisiae; See PMID 9818723
An01g00040	Function: in S. cerevisiae TFIIF is required for initiation at most, if not all, polymerase II promoters and probably contains three subunits in yeast, alpha, beta and a small subunit.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to alpha subunit of transcription initiation factor TFIIF Tfg1 - Saccharomyces cerevisiae [truncated ORF]; localisation:nucleus; See PMID 7995524
An01g00050	Catalytic activity: Acetyl-CoA + N malonyl-CoA + 2 NADH + 2 NADPH = a long-chain acyl-CoA + N CoA + N CO(2) + N NAD(+) + N NADP(+).; Remark: C-terminally truncated due to contig border.; Remark: FAS1 is a pentafunctional enzyme consisting of the following domains: acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase.; Title: similarity to fatty-acyl-CoA synthase beta chain Fas1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 3031066; See PMID 3528750
An01g00060	Catalytic activity: Acetyl-CoA + n Malonyl-CoA + 2n NADPH = long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).; Complex: Fatty acid synthetase is composed of [alpha(6)beta(6)] hexamers of the two multifunctional subunits FAS1 (alpha) and FAS2 (beta).; Title: strong similarity to fatty acid synthase alpha subunit fas2p - Schizosaccharomyces pombe; See PMID 9693066
An01g00070	Catalytic activity: S-Adenosyl-l-Methionine + tRNA = S-Adenosyl-l-Homocysteine + tRNA containing n(2)-Methylguanine.; Function: trm1 dimethylates a single guanine residue at position 26 of most tRNAs using S-Adenosyl-l -Methionine as donor of the methyl groups.; Remark: In the majority of eukaryotic tRNAs, the guanosine at position 26 is modified by a dimethyl group.; Title: strong similarity to N2,N2-dimethylguanosine tRNA methyltransferase trm1p - Schizosaccharomyces pombe; See PMID 10611485
An01g00080	Title: weak similarity to hypothetical membrane protein YOR228c - Saccharomyces cerevisiae
An01g00090	Title: weak similarity to secreted protein SEQ ID NO:901 from patent WO200155322-A2 - Homo sapiens
An01g00100	Catalytic activity: Pyruvate + lipoamide = S-acetyldihydrolipoamide + CO(2).; Complex: PDB1 is a component of the multienzyme pyruvate dehydrogenase complex.; Remark: PDB1 has the cofactor thiamin pyrophosphate.; Title: strong similarity to pyruvate dehydrogenase beta chain precursor Pdb1 - Saccharomyces cerevisiae; See PMID 8433986
An01g00110	Title: strong similarity to hypothetical protein SPAC1039.02 - Schizosaccharomyces pombe
An01g00120	Function: MRF1 is suggested to be a transcriptional regulator of genes involved in assembly of mitochondrial respiratory proteins.; Localization: Antibodies against MRF1 detected the antigen localized predominantly in the nucleus in vivo.; Title: similarity to mitochondrial respiratory function protein Mrf1 - Saccharomyces cerevisiae; nucleus; See PMID 8195160
An01g00130	Function: GatA is involved in the formation of correctly charged Gln-tRNA(Gln) through transamidation of misacylated Glu-tRNA(Gln).; Remark: The three genes, gatC, gatA, and gatB constitute Glu-tRNAGln amidotransferase which is a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.; Title: strong similarity to glutamyl-tRNA (Gln) amidotransferase chain A gatA - Bacillus subtilis; See PMID 9342321
An01g00140	Remark: Bre2 from S. cerevisiae is a subunit of a complex associated with Set1.; Similarity: Bre2 from S. cerevisiae is a member of the trxG gene super family, some human homologues of which are involved in hematopoiesis and leukemia.; Title: similarity to trithorax related protein Bre2 - Saccharomyces cerevisiae; See PMID 11742990
An01g00150	Function: ENP1is an essential nuclear protein with effects on N-glycosylation of proteins in the secretory pathway.; Localization: Immunohistochemical studies to define the cellular localization of the ENP1 protein revealed that it was localized to the nucleus.; Title: strong similarity to nuclear protein Enp1 -Saccharomyces cerevisiae; nucleus; See PMID 9034325
An01g00160	Function: the S. cerevisiae homolog HAC1 encodes the transcription factor that upregulates unfolded protein response (UPR) induced genes.; Pathway: unfolded protein response pathway (UPR).; Remark: an intracellular signaling from the endoplasmic reticulum (ER) to the nucleus, called the unfolded protein response (UPR), is activated when unfolded proteins are accumulated in the ER under a variety of stress conditions ('ER stress').; Remark: expression is controlled by regulated splicing of HAC1 mRNA. regulated mRNA splicing is initiated by Ire1p, and only the product of spliced mRNA is able to induce the response.; Title: similarity to regulator of unfolded protein response (UPR) Hac1 - Saccharomyces cerevisiae; See PMID 7816617
An01g00170	Remark: RAD52 Inhibitor (Fifty Two Inhibitor).; Title: similarity to hypothetical protein Fti1 -Saccharomyces cerevisiae; See PMID 9159472
An01g00190	Induction: priB transcript was abundant in primordia, while preprimordial mycelia and mature fruiting bodies contained lower levels of this transcript.; Remark: PRIB binds to the DNA fragment containing the upstream region of priB.; Remark: the PRIB binding site has a length of 16 bp and the consensus sequence 5' GGGGGGGACAGGANCC 3'.; Similarity: the predicted A. niger protein shows similarity to the PRIB protein of L. edodes and similarity to the GAL4 zinc binuclear cluster homology found in many transcription factors.; Title: similarity to protein PRIB - Lentinus edodes; See PMID 9498550; See PMID 8112580
An01g00200	Catalytic activity: succinyl-coa + a 3-oxo acid = succinate + a 3-oxo-acyl-coa.; Function: key enzyme for ketone body catabolism. transfers the coa moiety from succinate to acetoacetate. formation of the enzyme-coa intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.; Pathway: first step of ketolysis in extrahepatic tissues.; Title: strong similarity to succinyl-CoA:3-ketoacid-CoA transferase SCOT - Homo sapiens; localisation:mitochondrion; See PMID 8751852
An01g00210	Title: strong similarity to hypothetical protein AAO27753.1 - Fusarium sporotrichioides
An01g00220	Remark: Protein is probably involved in drug efflux. C-terminus truncated due to end of contig.; Title: strong similarity to hypothetical membrane protein YJR124c - Saccharomyces cerevisiae [truncated ORF]
An01g00240	Remark: CYP4F5 showed omega-hydroxylation activity toward leukotriene B4 (LTB4), a chemical mediator of inflammation.; Title: strong similarity to cytochrome P450 protein 4F5 - Rattus norvegicus; See PMID 8554568; See PMID 9344476
An01g00250	Catalytic activity: NADH + Nitrate = NAD+ + Nitrite + H2O.; Induction: light acts both directly as a signal and indirectly through photosynthesis to regulate the expression of genes encoding nitrate reductase (NR).; Remark: nitrate reductase (NR) is the first enzyme in nitrate assimilation.; Title: strong similarity to nitrate reductase NR2 -Arabidopsis thaliana; See PMID 9014362; See PMID 7991680
An01g00260	Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An01g00270	Remark: putative sequencing error - stop codon at residue 308. The deduced amino acid sequence of FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters. The disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid. Exression of FLU1 in YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide among the different drugs tested.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 11065353
An01g00280	Remark: possible phosphatase.; Title: strong similarity to hypothetical protein SPAC823.14 - Schizosaccharomyces pombe
An01g00290	Title: similarity to hypothetical protein encoded by An17g00430 - Aspergillus niger
An01g00310	Title: strong similarity to hypothetical protein encoded by An02g10090 - Aspergillus niger
An01g00320	Title: similarity to hypothetical protein encoded by An08g08380 - Aspergillus niger
An01g00330	Catalytic activity: hydrolysis of terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: acts only on small linear 1,5-alpha-linked l-arabinofuranosyl oligosaccharide.; Gene-ID: abfA;arfA;awabfA;exoA; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; See PMID 7764056; See PMID 8000538
An01g00340	Title: strong similarity to hypothetical protein SPCC320.08 - Schizosaccharomyces pombe
An01g00370	Function: aspartic proteinase; hydrolase; hydrolysis of proteins with broad specifity.; Title: strong similarity to aspergillopepsin apnS -Aspergillus phoenicis; See PMID 8142467
An01g00380	Function: Lactate transport across cell membranes is mediated by a family of proton-coupled monocarboxylate transporters (MCTs).; Localization: MCT3 of H. sapiens is uniquely expressed in the retinal pigment epithelium.; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 10510291
An01g00400	Title: strong similarity to hypothetical protein SPBC12C2.09c - Schizosaccharomyces pombe
An01g00420	Title: strong similarity to hypothetical protein encoded by An01g01580 - Aspergillus niger
An01g00430	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An01g00450	Function: mmsB of P. aeruginosa is involved in valine metabolism.; Phenotype: mmsB mutants of P. aeruginosa with insertionally inactivated mmsB grow slowly on valine/isoleucine medium and exhibit reduced enzyme activity in cell-free extracts compared to P. aeruginosa PAO.; Similarity: the ORF shows similarity to various dehydrogenases.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa
An01g00470	Title: strong similarity to hypothetical protein jhp0584 - Helicobacter pylori
An01g00480	Title: strong similarity to hypothetical protein AAO49461.1 - Leptosphaeria maculans
An01g00490	Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae
An01g00510	Catalytic activity: hydroxylation of n-alkanes at the terminal position.; Function: catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.; Remark: Overproduction of microsomal cytochrome P450Alk1(CYP 52A3) of Candida maltosa in S. cerevisiae resulted in an extensive proliferation of endoplasmic reticulum (ER) and induction of Kar2p and Pdi1p.; Title: strong similarity to cytochrome P450 cyp52A3-a - Candida maltosa; See PMID 8645001; See PMID 10050038
An01g00530	Catalytic activity: Preferential cleavage in B chain of insulin: Asn3+Gln, Gly13+Ala,Tyr26+Thr; Gene-ID: proctase-A; Remark: aspergillopepsin II is also called proteinase A or proctase-A. Proteinase A obtained from the culture medium of Aspergillus niger var. macrosporus is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin,diazoacetyl-DL-norleucine methyl ester,and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; localisation:extracellular/secretion proteins; similarity: belongs to peptidase family a4.; See PMID 9561230; See PMID 9561240; See PMID 1918059; See PMID 1918060
An01g00550	Function: rAsp f 4 of A. fumigatus expressed on the surface of the filamentous phage M13 is an allergen, which is bound by human serum IgE.; Title: strong similarity to allergen rAsp f 4 -Aspergillus fumigatus
An01g00560	Function: Sec11 from S. cerevisiae is a subunit of the microsomal signal peptidase, a complex of four polypeptides.; Function: Sec11 from S. cerevisiae is required for signal peptide cleavage, signal peptidase-dependent protein degradation, and yeast cell growth.; Title: strong similarity to signal peptidase subunit Sec11 - Saccharomyces cerevisiae; localisation:endoplasmatic reticulum; See PMID 9148930; See PMID 1846444; See PMID 3283143
An01g00570	Title: weak similarity to hypothetical protein -Campylobacter jejuni
An01g00600	Remark: putative reductase; Title: similarity to hypothetical protein YLR011w -Saccharomyces cerevisiae
An01g00610	Title: strong similarity to hypothetical protein BAC69773.1 - Streptomyces avermitilis
An01g00620	Function: converts p-cumic aldehyde + H20 + NAD to p-cumate + NADH; Remark: Pseudomonas putida F1 utilizes p-cymene (p-isopropyltoluene) by an 11-step pathway through p-cumate (p-isopropylbenzoate) to isobutyrate, pyruvate, and acetyl coenzyme A.; Title: strong similarity to p-cumic aldehyde dehydrogenase cymc - Pseudomonas putida; See PMID 8631713; See PMID 9150211
An01g00630	Remark: Acinetobacter sp. strain ADP1 is able to grow on a range of esters of aromatic alcohols, converting them to the corresponding aromatic carboxylic acids by the sequential action of three inducible enzymes: an areA-encoded esterase, an areB-encoded benzyl alcohol dehydrogenase, and an areC-encoded benzaldehyde dehydrogenase.; Title: strong similarity to benzyl alcohol dehydrogenase areB - Acinetobacter sp.; See PMID 10419955
An01g00640	Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An01g00660	Title: similarity to hypothetical protein rfeF -Aspergillus nidulans
An01g00680	Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O.; Similarity: avnA of Aspergillus parasiticus is involved in aflatoxin biosynthetic pathway; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431
An01g00690	Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism
An01g00700	Remark: Overexpression of RTM1 confers resistance to the toxicity of molasses. The RTM1 gene encodes a hydrophobic 34-kD protein that contains seven potential transmembrane-spanning segments.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593
An01g00710	Function: aromatic-L-amino-acid decarboxylases catalyses the decarboxylation of tryptophan to tryptamine.; Function: ddc of Sorangium cellulosum is converting L-dopa (dihydroxy- L-phenylalanine) to dopamine.; Remark: the predicted ORF is a probable pyridoxal-dependent decarboxylase family member.; Similarity: the ORF shows similarity to pyridoxal phosphate-dependent carboxylases involved in the decarboxylation of aromatic amino acids, which in some cases leads to the synthesis of alkaloids/eucaryotic neurotransmitters like dopamine.; Title: strong similarity to aromatic amino acid decarboxylase ddc - Sorangium cellulosum; See PMID 10816050
An01g00720	Function: sit1 of S. cerevisiae is a ferrioxamine B permease involved in siderophore (microbial iron chelators) iron transport.; Phenotype: S. cerevisiae cells with a deleted sit1 gene are unable to take up ferrioxamine B.; Remark: sit1 of S. cerevisiae is also called ARN3 or YEL065W.; Similarity: the ORF shows similarity to several major facilitator protein homologs from different species and with various specificities.; Title: strong similarity to transporter sit1 -Saccharomyces cerevisiae; See PMID 10816729
An01g00730	Remark: the ORF is truncated due to the contig border.
An01g00740	Remark: N-terminally truncated due to contig border.
An01g00770	Function: pMSS116 promotes ATP-dependent splicing of group II introns in yeast.; Localization: pMSS116 is localized in the mitochondrial matrix.; Similarity: pMSS116 has DEAD/H box RNA helicase homology.; Title: similarity to RNA helicase Mss116 -Saccharomyces cerevisiae; See PMID 2535893; See PMID 7567443
An01g00780	Catalytic activity: Endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans.; Gene-ID: xynB; Pathway: Xylan degradation.; Similarity: Belongs to cellulase family g (family 11 of glycosyl hydrolases).
An01g00800	Title: similarity to hypothetical protein AAO51454.1 - Dictyostelium discoideum
An01g00810	Title: weak similarity to androgen receptor A hARa -Homo sapiens
An01g00820	Function: The QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium.; Localization: The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Similarity: The QutD gene shows strong homology with the N. crassa QA-Y gene.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880
An01g00850	Function: Xylose uptake in Bacillus megaterium depends on expression of a H+/xylose symporter encoded by xylT, the last gene in the xyl operon.; Remark: Expression of xylT is xylose inducible.; Title: similarity to xylose permease xylT - Bacillus megaterium; See PMID 9076741
An01g00860	Catalytic activity: DHGO is an enzyme catalyzing the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to (+)- geodin.; Remark: a putative frameshift results in an premature STOP codon.; Similarity: DHGO shows significant homology with multicopper blue proteins such as laccase and ascorbate oxidase.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus [putative frameshift]; putative frameshift; See PMID 7665560
An01g00870	Catalytic activity: COQ2 catalyzes the transfer of the polyisoprenoid side chain to para-hydroxybenzoate (PHB).; Pathway: COQ2 catalyzes a step in the biosynthesis of the lipid-soluble electron carrier Coenzyme Q.; Remark: The amino acid sequence of COQ2 exhibits a typical amino-terminal mitochondrial leader sequence and six potential membrane-spanning domains.; Title: strong similarity to para-hydroxybenzoate polyprenyltransferase Coq2 - Saccharomyces cerevisiae; See PMID 1740455
An01g00880	Catalytic activity: 6-OMT catalyzes the transfer of the S-methyl group of S-adenosyl-L-methionine to the 6-hydroxyl group of 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquin olinediol (norcoclaurine).; Pathway: 6-OMT catalyzes an early step in the biosynthetic pathway to reticuline, an important intermediate in synthesizing isoquinoline alkaloids.; Title: strong similarity to S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase 6-OMT - Coptis japonica; See PMID 7925429; See PMID 10811648
An01g00890	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An01g00900	Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; Function: pyp2+ encodes a nonreceptor type protein tyrosine phosphatase that negatively regulates mitosis.; Title: similarity to protein-tyrosine-phosphatase pyp2p - Schizosaccharomyces pombe; See PMID 1448087; See PMID 1464319
An01g00910	Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An01g00920	Title: strong similarity to hypothetical lysogenic protein CAD54907.1 - Bacteriophage P2-EC58
An01g00930	Catalytic activity: Methyl chloride transferase catalyzes the synthesis of methyl chloride from S-adenosine-L-methionine and chloride ion.; Title: similarity to methyl chloride transferase AAC72357.1 - Batis maritima; See PMID 9789006
An01g00940	Title: weak similarity to AP-1-like stress-induced transcriptional activator Yap2 - Saccharomyces cerevisiae
An01g00950	Title: weak similarity to hypothetical protein encoded by An11g07790 - Aspergillus niger
An01g00960	Title: strong similarity to hypothetical oxidoreductase DR2595 - Deinococcus radiodurans
An01g00970	Title: similarity to hypothetical protein encoded by An11g04000 - Aspergillus niger
An01g00990	Title: weak similarity to hypothetical protein encoded by An01g12970 - Aspergillus niger
An01g01000	Title: similarity to hypothetical protein BAC11036.1 - Homo sapiens
An01g01010	Title: weak similarity to hypothetical protein Y49E10.24 - Caenorhabditis elegans
An01g01020	Title: similarity to protein SEQ ID NO:628 from patent WO200222660-A2 - Homo sapiens
An01g01030	Title: weak similarity to hypothetical protein encoded by An16g05360 - Aspergillus niger
An01g01040	Function: Ank3 plays an important role in the polarized distribution of many integral membrane proteins.; Function: the ankyrin domain is supposed to mediate protein-protein interactions.; Localization: Ank3 is a broadly distributed epithelial ankyrin and is the major ankyrin in the kidney and other tissues.; Remark: Ank3 is expressed in alternatively spliced forms including forms that lack the NH2-terminal repeat domain.; Title: similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 7615634; See PMID 9060470
An01g01050	Title: similarity to hypothetical protein YLR007w -Saccharomyces cerevisiae
An01g01060	Complex: Forms a heterodimer with the spU2AF59 large subunit.; Function: spU2AF23 is the SNRNP auxiliary factor small subunit which is necessary for the splicing of pre-mRNA.; Localization: Nuclear protein.; Remark: Binds to the polypyrimidine tract of introns early during spliceosome assembly.; Title: strong similarity to splicing factor spU2AF23 - Schizosaccharomyces pombe; See PMID 8657565
An01g01070	Title: strong similarity to hypothetical protein BAB09014.1 - Arabidopsis thaliana
An01g01080	Catalytic activity: 7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH.; Pathway: Sepiapterin reductase SPR (7,8-dihydrobiopterin: NADP+ oxidoreductase) catalyzes the terminal step in the biosynthetic pathway for tetrahydrobiopterin, the cofactor necessary for aromatic amino acid hydroxylation.; Title: strong similarity to sepiapterin reductase SPR - Rattus norvegicus; See PMID 2201030; See PMID 2260974
An01g01090	Complex: Dr1 directly interacts with the TATA-binding protein (TBP) subunit of the multiprotein TFIID complex.; Function: Dr1 has a regulatory role in repression of class II gene transcription that is mediated via phosphorylation.; Title: similarity to TATA-binding protein-associated phosphoprotein Dr1 - Homo sapiens; See PMID 7958881; See PMID 1339312
An01g01110	Function: Pseudomonas sp. hyuA is involved in the conversion of D-5-substituted hydantoins to corresponding N-carbamyl-D-amino acids.; Title: strong similarity to D-amino acid hydantoin hydrolase hyuA - Pseudomonas sp.; See PMID 1732229
An01g01120	Title: similarity to hypothetical protein encoded by An11g03480 - Aspergillus niger
An01g01130	Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619
An01g01140	Title: strong similarity to hypothetical protein encoded by An01g12050 - Aspergillus niger
An01g01150	Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Remark: the adjacent genomic region contains another predicted A. niger protein with similarity to M. grisea PTH11.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of M. grisea PTH11, which is 100 aa longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; localisation:plasma membrane; See PMID 10521529
An01g01160	Function: S. viridochromogenes pat is involved in the metabolism of the herbicide glufosinate and can confer resistance against glufosinate.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. viridochromogenes pat, which is 100 aa shorter.; Title: similarity to phosphinothricin N-acetyltransferase pat - Streptomyces viridochromogenes; See PMID 3240868
An01g01170	Title: strong similarity to hypothetical protein BAC47708.1 - Bradyrhizobium japonicum
An01g01180	Similarity: the C-terminal region of the predicted A. niger protein contains a chromate transporter motif.; Title: strong similarity to hypothetical conserved protein CAD21291.1 - Neurospora crassa
An01g01190	Similarity: the predicted A. niger protein contains a phosphoglycerate mutase motif.; Title: similarity to hypothetical phosphoglycerate mutase SPAC5H10.03 - Schizosaccharomyces pombe
An01g01210	Function: R. norvegicus acyl-peptide hydrolase is a serine protease which catalyzes the removal of an N alpha-acetylated amino acid residue from an N alpha-acetylated peptide.; Similarity: the predicted A. niger protein shows strong similarity to several putative mikrobial acyl-peptide hydrolases.; Title: similarity to acylaminoacyl-peptidase -Rattus norvegicus; See PMID 2722805
An01g01220	Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Remark: the adjacent genomic region contains another predicted A. niger protein with similarity to M. grisea PTH11.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of M. grisea PTH11, which is 200 aa longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; localisation:plasma membrane; See PMID 10521529
An01g01230	Title: strong similarity to hypothetical protein SPAC869.06c - Schizosaccharomyces pombe
An01g01240	Function: C. carbonum TOXA likely encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: ORF 5'truncated due to end of contig.; Remark: the function of C. carbonum TOXA is indicated by its sequence similarity to the major facilitator superfamily and the impossibility to mutate TOXA in HC-toxin producing strains.; Similarity: C. carbonum TOXA is a member of the major facilitator superfamily.; Title: similarity to HC-toxin efflux pump TOXA -Cochliobolus carbonum [truncated ORF]; localisation:plasma membrane; See PMID 8704997
An01g01250	Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: belongs to the major falicitator superfamily (MFS).; Title: strong similarity to hypothetical membrane transport protein SPAC3H1.06c - Schizosaccharomyces pombe [truncated ORF]
An01g01260	Catalytic activity: beta-D-glucuronoside + H2O = D-glucuronate + alcohol.; Function: beta-glucuronidase of E. coli is widely used as a gene expression reporter in transgenic organisms.; Repression: expression of uidA in E. coli is negatively controlled by the products of the uidR and uxuR genes and is sensitive to catabolite repression.; Title: strong similarity to beta-glucuronidase uidA - Escherichia coli; See PMID 1323505; See PMID 2504501; See PMID 2823062
An01g01270	Remark: the ORF is short in length (86 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An01g01280	Function: expression of the membrane pump protein of patent W35808 regulates cercosporin production and pathogenicity of C. kikuchii.; Function: the membrane protein pump of patent W35808 confers resistance to the polyketide phytotoxin cercosporin.; Similarity: also shows strong similarity to hypothetical HC-toxin efflux pump TOXA of Cochliobolus carbonum (PubMed 8704997).; Similarity: belongs to the major facilitator superfamily of transmembrane transport proteins.; Similarity: shows strong similarity to protein patent database entry GENESEQPROT:W35808.; Title: strong similarity to cercosporin resistance transmembrane efflux pump from patent WO9735001-A1 -Cercospora kikuchii
An01g01290	Catalytic activity: SHC in A. acidocaldarius catalyzes the cyclization of squalene into hopene.; Pathway: SHC in A. acidocaldarius is the key enzyme in the synthesis of pentacyclic hopanoids (triterpenoids).; Similarity: also shows strong similarity to lanosterol synthase (EC 5. 4. 99. 7) of Alicyclobacillus acidoterrestris.; Similarity: belongs to the terpene cyclase/mutase family.; Title: strong similarity to squalene-hopene cyclase SHC - Alicyclobacillus acidocaldarius; localisation:plasma membrane; See PMID 9295270; See PMID 1729216
An01g01320	Catalytic activity: Asp 130 within the conserved YLKYDNC motif is the catalytic nucleophile in the active site of agal in P. chrysosporium.; Catalytic activity: alpha-galactosidases catalyze the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides.; Function: alpha-galactosidase of C. tetragonoloba is involved in the hydrolysis of galactomannans and melibiose.; Similarity: also shows strong similarity to alpha-galactosidase from Cyamopsis tetragonoloba (guar) of protein patent GENESEQPROT:R70206.; Similarity: belongs to family 27 of glycosyl hydrolases.; Similarity: contains the YLKYDNC motif which is highly conserved in all known family 27 glycosyl hydrolases.; Title: strong similarity to alpha-galactosidase agal - Phanerochaete chrysosporium; See PMID 10933800; See PMID 2577496
An01g01330	Function: FacB of E. nidulans is a hypothetical DNA-binding transcriptional activator involved in the regulation of acetamide and acetate utilisation.; Similarity: the ORF shows similarity to several transcription activators.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An01g01340	Function: UGL of Bacillus sp. GL1 hydrolyzes the tetrasaccharide of unsaturated glucuronyl-glucosyl-rhamnosyl-glucose releasing unsaturated glucuronate.; Pathway: UGL of Bacillus sp. GL1 is involved in the degradation of oligosaccharides with an unsaturated uronic acid at the nonreducing terminal produced by polysaccharide lyases.; Title: similarity to unsaturated glucuronyl hydrolase UGL - Bacillus sp.; See PMID 10441389
An01g01350	Function: S. cerevisiae TNA1 encodes the yeast high affinity nicotinic acid permease.; Regulation: S. cerevisiae TNA1 is repressed by nicotinate and p-aminobenzoate.; Remark: the systematic name for S. cerevisiae TNA1 is YGR260W.; Similarity: S. cerevisiae TNA1 is a member of the yeast Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An01g01360	Title: similarity to hypothetical transmembrane protein CAD18032.1 - Ralstonia solanacearum
An01g01370	Title: strong similarity to hypothetical protein encoded by An06g01030 - Aspergillus niger
An01g01380	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An01g01390	Complex: the yeast SWI/SNF chromatin remodeling complex is comprised of 11 tightly associated polypeptides (SWI1, SWI2, SWI3, SNF5, SNF6, SNF11, SWP82, SWP73, SWP59 (Arp9), SWP61, and SWP29).; Function: S. cerevisiae Arp9 is a component of the RSC and SWI/SNF chromatin remodeling complex with structural roles, as the ATPase activity is not required for Arp9 function.; Remark: the systematic name for S. cerevisiae Arp9 is YMR033w an alias is SWP59.; Similarity: S. cerevisiae Arp9 is a member of the actin-related protein (ARP) family of ATPases.; Title: similarity to chromatin remodeling Snf/Swi complex subunit Arp9 - Saccharomyces cerevisiae; localisation:nucleus; See PMID 9726966; See PMID 9844636; See PMID 10529347; See PMID 10753786
An01g01400	Title: strong similarity to hypothetical protein encoded by slr0318 - Synechocystis sp.
An01g01410	Title: strong similarity to hypothetical protein encoded by An01g01460 - Aspergillus niger
An01g01420	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An01g01430	Function: S. lavendulae mcrA protects this microorganism from its own antibiotic, the antitumor drug mitomycin C.; Function: the predicted A. niger protein shows high similarity to a putative FAD-dependent oxygenase encM from the enterocin biosynthetic gene cluster of Streptomyces maritimus and therefore might be involved in toxin synthesis.; Title: similarity to hydroquinone oxidase mcrA -Streptomyces lavendulae; See PMID 10468636; See PMID 11137817
An01g01440	Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An01g01460	Title: strong similarity to hypothetical protein encoded by An01g01410 - Aspergillus niger
An01g01470	Title: similarity to hypothetical protein encoded by An08g11970 - Aspergillus niger
An01g01480	Function: the S. cerevisiae antibiotic resistance protein QDR1 confers resistance to the antiarrhythmic and antimalarial quinoline ring-containing drug Quinidine.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822
An01g01490	Title: similarity to hypothetical protein B3E4.80 -Neurospora crassa
An01g01500	Function: mouse KIN17, a nuclear zinc finger protein, binds to the curved DNA fragments found at illegitimate recombination sites.; Function: overexpression of mouse KIN17 inhibits cellular proliferation.; Induction: mouse KIN17 is expressed after induction of S-phase and after UV-exposure.; Similarity: mouse KIN17 shares epitopes with the bacterial RecA protein, which controls the expression of the SOS UV-response genes.; Title: strong similarity to UV-response Zn-finger protein kin17 - Mus musculus; localisation:nucleus; See PMID 8078469; See PMID 9635863; See PMID 10413603
An01g01520	Catalytic activity: pyrroline-5-carboxylate reductases convert L-proline + NAD(P)(+) to 1-pyrroline-5-carboxylate + NAD(P)H.; Function: Z. arboricola P5CR plays a role in the final step of proline biosynthesis.; Remark: an alternative name for Z. arboricola P5CR is Delta 1-pyrroline-5-carboxylate reductase.; Title: similarity to pyrroline-5-carboxylate reductase P5CR - Zalerion arboricola; See PMID 8654976
An01g01530	Catalytic activity: proline dehydrogenases convert L-proline + acceptor + H(2)O to (S)-1-pyrroline-5-carboxylate + reduced acceptor.; Function: proline dehydrogenase is a mitochondrial enzyme which catalyzes the first step in the conversion of proline to glutamate.; Title: similarity to proline dehydrogenase slgA -Drosophila melanogaster; localisation:mitochondrium; See PMID 8096642
An01g01540	Function: A. nidulans treA is an acid trehalase required for utilisation of the extracellular disaccharide trehalose.; Localization: A. nidulans treA is localized in the conidiospore wall.; Title: strong similarity to alpha,alpha-trehalase treA - Aspergillus nidulans; localisation:cell wall; See PMID 9140977; See PMID 9308367
An01g01550	Catalytic activity: catalases convert 2 H(2)O(2) to O(2) + 2 H(2)O.; Function: catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Title: strong similarity to catalase cat1 -Aspergillus fumigatus; See PMID 9353056
An01g01560	Title: similarity to hypothetical protein yxaG -Bacillus subtilis
An01g01580	Title: strong similarity to hypothetical protein encoded by An01g00420 - Aspergillus niger
An01g01590	Function: pyruvate decarboxylase is the key enzyme in the glycolytic-fermentative pathway of ethanol production in fungi, and in certain plants and bacteria.; Remark: N. crassa harbors large amounts of cytoplasmic filaments which are homopolymers of a 59-kDa polypeptide, pyruvate decarboxylase.; Remark: a possible sequencing error occured at position 38662, giving rise to a frame-shift, and was removed.; Remark: the predicted A. niger protein shows similarities to pyruvate decarboxylase of N. crassa as well as of other organisms in its C-terminal region whereas the N-terminal region shows homologies to alcohol dehydrogenase enzymes.; Title: similarity to pyruvate decarboxylase PDC -Neurospora crassa [putative frameshift]; localisation:cytoplasm; putative frameshift; See PMID 8359692
An01g01600	Function: M. auratus MCT2 facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates.; Similarity: M. auratus MCT2 belongs to the monocarboxylate transporter family.; Title: similarity to monocarboxylate transporter 2 MCT2 - Mesocricetus auratus; See PMID 7829520
An01g01620	Function: S. cerevisiae ZRT1 is involved in zinc import into the cell.; Induction: S. cerevisiae ZRT1 is expressed in response to zinc deficiency.; Remark: alternative names for S. cerevisiae ZRT1 are YGL255W and FZF1.; Title: strong similarity to high-affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; See PMID 8637895; See PMID 9618566; See PMID 10748254
An01g01630	Title: strong similarity to hypothetical protein encoded by An09g00510 - Aspergillus niger
An01g01640	Catalytic activity: E. gunnii CAD 1 catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Function: E. gunnii cinnamyl alcohol dehydrogenase is considered a key enzyme in lignin biosynthesis.; Pathway: E. gunnii CAD 1 is involved in lignin biosynthesis.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508
An01g01650	Title: similarity to hypothetical protein encoded by An12g05420 - Aspergillus niger
An01g01660	Function: Acinetobacter salE shows activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: weak similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An01g01670	Title: similarity to hypothetical protein encoded by An01g11590 - Aspergillus niger
An01g01680	Title: similarity to hypothetical protein encoded by An01g01690 - Aspergillus niger
An01g01690	Title: similarity to hypothetical protein encoded by An01g01680 - Aspergillus niger
An01g01720	Function: S. cerevisiae blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity.; Similarity: S. cerevisiae BLH1 is a member of the cysteine protease family.; Title: strong similarity to bleomycin hydrolase Blh1 - Saccharomyces cerevisiae; See PMID 8463237
An01g01730	Title: strong similarity to hypothetical protein encoded by An12g06350 - Aspergillus niger
An01g01740	Title: weak similarity to troponin C -Caenorhabditis elegans
An01g01750	Function: Rattus norvegicus CLN2 is a lysosomal protease.; Similarity: Rattus norvegicus CLN2 shows similarity to prokaryotic pepstatin-insensitive acid proteases.; Title: similarity to lysosomal protease CLN2 -Rattus norvegicus; localisation:lysosome; See PMID 10428067
An01g01760	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An01g01780	Localization: PTH11 of M. grisea was localized as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: strong similarity to transmembrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g01790	Remark: Band 3 of the erythrocyte cytoskeleton is a central component taking part in two widely divergent functions of erythroid cells; it is a primary determinant of cytoskeletal architecture and responsible for electroneutral Cl-/HCO3- exchange across the plasma membrane.; Title: similarity to band 3 anion transport protein - Gallus gallus; See PMID 3185555
An01g01810	Function: plays a role in the entry into G0,possibly by facilitating the release of a signaling substance into the environment as a means of cell-to-cell communication.; Similarity: fnx1(+) encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An01g01820	Catalytic activity: 2 H2O2 = O2 + 2 H2O; Function: occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Gene-ID: catR; Similarity: belongs to the catalase family.; localisation:peroxisome; See PMID 7934925
An01g01830	Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Function: Streptomyces reticuli produces a mycelium-associated enzyme (CpeB) which exhibits heme-dependent catalase and peroxidase activity, as well as heme-independent manganese-peroxidase activity. The catalase-peroxidase CpeB and its apo-form (obtained after extraction of heme catalyze the peroxidation of Mn(II) to Mn(III), independent of the presence or absence of the heme inhibitor KCN.; Title: strong similarity to catalase/peroxidase cpeB - Streptomyces reticuli; See PMID 10217488; See PMID 10806381
An01g01840	Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2; Remark: MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA), unlike human MAO-A and MAO-B, which oxidize only 5-HT and PEA, respectively.; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446
An01g01850	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An01g01860	Remark: Homology is only based on repetitive sequence.; Title: similarity to hypothetical protein encoded by An17g00940 - Aspergillus niger
An01g01870	Function: putative cellulase.; Similarity: fungal cellulose-binding domain homology.; Title: strong similarity to hypothetical Avicelase III aviIII - Aspergillus aculeatus
An01g01880	Catalytic activity: (s)-lactate + o(2) = acetate + co(2) + h(2)o.; Similarity: belongs to the fmn-dependent alpha-hydroxy acid dehydrogenases family.; Title: strong similarity to L-lactate 2-monooxygenase LA2M - Mycobacterium smegmatis; See PMID 9341146; See PMID 2324094
An01g01900	Function: Mct is a component of a novel drug export system specific to the mitomycins. Mct encodes a hydrophobic polypeptide that has significant amino acid sequence similarity with several actinomycete antibiotic export proteins.; Title: strong similarity to mitomycin C translocase mct - Streptomyces lavendulae; See PMID 10198016
An01g01920	Catalytic activity: hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; Similarity: similarity to bacterial and eukaryotic beta-N-acetylhexosaminidases.; Title: similarity to beta-N-acetylhexosaminidase -Vibrio furnissii; See PMID 8969206; See PMID 10398828
An01g01940	Function: UGA4 of S. cerevisiae is a GABA-specific high-affinity permease.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 7888172; See PMID 8455553
An01g01950	Similarity: all yeast homologs are about 400 aminoacids longer at N-terminus.; Similarity: bacterial homologs have about the same length.; Title: similarity to aluminium resistance protein Alr1 - Saccharomyces cerevisiae; See PMID 9430719; See PMID 10220002
An01g01960	Catalytic activity: catalyzes the reduction of 2,4 diamino-6-ribitylamino-4(3H)-pyrimidine 5'-phosphate by NADPH to yield DRTP.; Pathway: riboflavin biosynthesis (second step).; Title: strong similarity to riboflavin biosynthesis protein Rib7 - Saccharomyces cerevisiae; See PMID 3547188; See PMID 8256517
An01g01970	Title: similarity to hypothetical protein encoded by An04g02750 - Aspergillus niger
An01g02000	Catalytic activity: L-Tryptophan = Tryptamine + CO2; EC:4.1.1.28; Pathway: Histidine metabolism; Tyrosine metabolism; Phenylalanine metabolism; Tryptophan metabolism; Alkaloid biosynthesis I.; Title: similarity to aromatic-L-amino-acid decarboxylase DDC - Rattus norvegicus; See PMID 7567987
An01g02010	Similarity: blast matches to acid rich proteins due to serine and aspartic acids repeats.
An01g02020	Title: strong similarity to hypothetical protein ssl3291 - Synechocystis sp.
An01g02030	Function: FUM5 of G. fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: all homologs are N-terminal much longer.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis; See PMID 10413619; See PMID 10802562; See PMID 10872449; contains an internal stop codon; uncharacterized protein
An01g02050	Remark: At221 might be involved in the gene expression regulation of lovF.; Title: similarity to gene expression regulator At221 from patent WO200257456-A2 - Unclassified organism
An01g02060	Similarity: similarity to YOR306c, YNL125c, YKL221w and monocarboxylate transporter proteins.; Title: similarity to monocarboxylate transporter 3 -Gallus gallus; See PMID 9168967
An01g02070	Function: A. fumigatus secretes a serine alkaline protease (ALP) and a metalloprotease (MEP) when the fungus is cultivated in the presence of collagen as sole nitrogen and carbon source.; Remark: putative sequencing error at position 82586 (Stop); Remark: strong similarity to metalloproteases from aspergillus.; Title: strong similarity to metalloprotease mep -Aspergillus fumigatus; extracellular/secretion proteins; See PMID 7715453
An01g02080	Title: similarity to hypothetical protein SC2G5.30 -Streptomyces coelicolor
An01g02090	Title: similarity to hypothetical protein BX908807_12 - Neurospora crassa
An01g02100	Function: Pus4p of S. cerevisiae catalyzes the formation of psi55 in both mitochondrial and cytoplasmic tRNAs.; Title: strong similarity to tRNA-pseudouridine synthase Pus4 - Saccharomyces cerevisiae; See PMID 9358157
An01g02110	Title: similarity to hypothetical protein CAD11409.1 - Neurospora crassa
An01g02120	Function: Ebp2p of S. cerevisiae is required for the maturation of 25S rRNA and 60S subunit assembly; it may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis.; Remark: EbP2p is the genename for YKL172w of S. cerevisiae.; Similarity: shows also similarity to human nucleolar protein p40.; Title: strong similarity to nucleolar protein Ebp2 -Saccharomyces cerevisiae; nucleus; See PMID 10849420; See PMID 10947841; See PMID 11226172
An01g02130	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An01g02140	Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260w.; Similarity: the ORF shows similarity to some allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 10373489
An01g02150	Function: arcA of A. nidulans is, together with suDpro and suEpro, responsible for regulation of synthesis of arginine catabolic enzymes.; Title: strong similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans; See PMID 62492
An01g02160	Function: fnx1 of S. pombe required for entry into the quiescent G0 state, that is normally induced by nitrogen starvation.; Similarity: similarity to several multidrug resistance proteins.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An01g02170	Similarity: similarity to S. pombe hypothetical protein SPAC13C5. 04, similarity to several esterases; Title: similarity to anthranilate converting enzyme tdnT - Pseudomonas putida; See PMID 8990291
An01g02180	Title: similarity to hypothetical protein YOL032w -Saccharomyces cerevisiae
An01g02190	Catalytic activity: ATP + Thiamine = AMP + Thiamine diphosphate.; Pathway: Thiamine metabolism.; Title: similarity to thiamin pyrophosphokinase tnr3p - Schizosaccharomyces pombe; See PMID 6282163; See PMID 7499352
An01g02200	Catalytic activity: nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1).; Remark: RNA polymerases I, II, and III of S. cerevisiae share three subunits that are immunologically and biochemically indistinguishable (RPB5, RPB6, and RPB8).; Title: strong similarity to 16 kD subunit of DNA-directed RNA polymerase I,II,III Rpb8 - Saccharomyces cerevisiae; nucleus; See PMID 1408842; See PMID 10653691
An01g02210	Title: similarity to hypothetical protein SPCC11E10.06c - Schizosaccharomyces pombe
An01g02220	Complex: in S. cerevisiae the tRNA splicing endonuclease is a tetrameric enzyme.; Function: in S. cerevisiae the tRNA splicing endonuclease is responsible for identification and cleavage of the splice sites in pre-tRNA.; Function: splicing of tRNA precursors is essential for the production of mature tRNA.; Title: strong similarity to tRNA splicing endonuclease gamma subunit Sen34 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 9200603
An01g02230	Remark: ribonuclease P is involved in processing of tRNAs and rRNAs.; Title: similarity to ribonuclease P protein subunit p29 - Homo sapiens; See PMID 9759486; See PMID 10024167
An01g02240	Similarity: shows similarity to several oxidoreductases with different specificities, e. g 1-aminocyclopropane-1-carboxylic acid oxidases.; Title: similarity to 1-aminocyclopropane-1-carboxylic acid oxidase - Cucumis sativus; See PMID 10608661
An01g02250	Title: weak similarity to hypothetical AAA-ATPase AAR34299.1 - Geobacter sulfurreducens
An01g02260	Similarity: C-terminus shows weak similarity to central part of bacterial ftsZ proteins.; Title: strong similarity to hypothetical protein encoded by An07g04490 - Aspergillus niger
An01g02270	Catalytic activity: rinonuclease H catalyzes the endonucleolytic cleavage to 5'-phospho- monoester.; Function: ribonuclease H is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically.; Title: similarity to ribonuclease H1 RNH1 -Trypanosoma brucei; See PMID 9178276
An01g02280	Similarity: shows only weak similarity to N-terminal part of hypothetical protein DR0458 of Deinococcus radiodurans.
An01g02300	Similarity: all matching proteins are 20-50 aminoacids longer at the C-terminus.; Title: similarity to glia maturation factor BmGMF -Brugia malayi; See PMID 7820553; See PMID 9047337
An01g02310	Remark: shows similarity to several bacterial competence-damage proteins.; Title: strong similarity to hypothetical protein YMR178w - Saccharomyces cerevisiae
An01g02320	Function: Aras of A. nidulans is an essential gene that regulates the ordered program of development.; Title: strong similarity to GTP-binding protein a-ras - Aspergillus nidulans; See PMID 8035812; See PMID 10835388
An01g02330	Title: similarity to pyoverdine biosynthesis protein PvcA - Pseudomonas aeruginosa; See PMID 8704959; See PMID 10383985
An01g02340	Similarity: shows strong similarity to several dehydrogenases.; Title: strong similarity to hypothetical short chain dehydrogenase SPAC521.03 - Schizosaccharomyces pombe
An01g02350	Remark: the human NK cell antigen DX1 has the patent-number WO9502611-A.; Title: weak similarity to NK cell antigen DX1 - Homo sapiens
An01g02360	Function: M. grisea pth11p is a plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cues.; Remark: putative short form of M. grisea pth11p.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g02370	Function: the Aspergillus nidulans SREA is involved in regulation of siderophore biosynthesis and control of iron uptake.; Title: strong similarity to siderophore biosynthesis repressor sREA - Aspergillus nidulans; See PMID 9988696
An01g02410	Title: similarity to hypothetical protein SPAC6F12.04 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift
An01g02420	Title: similarity to hypothetical protein SC6F7.17c - Streptomyces coelicolor
An01g02430	Catalytic activity: the F. solani D-amino acid oxidase converts D-amino acid and H2O and O2 to 2-oxo acid and NH3 and H2O2.; Catalytic activity: the F. solani D-amino acid oxidase is able to oxidatively deaminate cephalosporin C to 7-beta-(5-carboxy-5-oxopentanamido)cephalosporanic acid.; Remark: the D-amino acid oxidase posseses a wide specificity for D-amino acids and also acts on glycine.; Title: strong similarity to D-amino-acid oxidase DAO - Fusarium solani; peroxisome; See PMID 1982443
An01g02440	Title: similarity to hypothetical protein K21H1.13 -Arabidopsis thaliana
An01g02460	Title: strong similarity to hypothetical protein EAA66045.1 - Aspergillus nidulans
An01g02500	Function: thioredoxin is involved in oxidative stress response and redox regulation.; Localization: the S. cerevisiae TRX1 and TRX2 are located in the cytoplasm, while TRX3 is located in the mitochondrion.; Remark: the A. nidulans thioredoxin is an intercellular disulphide-reducing enzyme which exhibits an unusual fluorescence emission spectrum, characterized by a high contribution of tyrosine residues.; Remark: the amino acid sequence of A. nidulans thioredoxin was determined by automated Edman degradation.; Similarity: the A. nidulans thioredoxin displays a sequence similarity of 45% to at least one of three thioredoxin homologues in S. cerevisiae TRX1, TRX2 and TRX3.; Title: strong similarity to thioredoxin -Aspergillus nidulans; See PMID 1459127
An01g02540	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02550	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02560	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02570	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02600	Remark: the adaptin complex proteins are involved in the formation of clathrin coated pits and vesicels.; Similarity: the predicted A. niger protein reveals two conserved domains, the adaptin N-terminal region (aa 24-587, PF01602) and the C-terminal gamma-adaptin domain (aa 726-848, PF02139), who are together part of the adaptin complex (AP-complex).; Title: strong similarity to gamma1-adaptin - Homo sapiens; See PMID 9733768
An01g02610	Title: strong similarity to EST an_2155 -Aspergillus niger
An01g02620	Function: A. oryzae nuclear protein HAPC binds specifically to a CCAAT sequence in the promoter region of the A. oryzae Taka-amylase A gene.; Similarity: the predicted A. niger protein contains a CBFD-NFYB-HMF domain (aa 47-115, PF00808) which is typical for histone like transcription factors.; Title: strong similarity to CCAAT-binding protein hapC - Aspergillus oryzae; nucleus; See PMID 10905428
An01g02630	Pathway: amdR in A. oryzae and in A. nidulans is involved in the capability of the fungi to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to transcription regulator amdR - Aspergillus nidulans; nucleus; See PMID 1479891
An01g02640	Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Pathway: omtB of A. parasiticus is a component of the aflatoxin biosynthesis gene cluster.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: omtB of A. parasiticus is also called dmtA.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361
An01g02650	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02660	Title: strong similarity to hypothetical protein encoded by An03g05810 - Aspergillus niger
An01g02670	Function: the S. pombe scn1 protein interact with the CUT9 protein, a putative component of anaphse-promoting complex (APC) which is required for cyclin degradation and metaphase-anaphase transition.; Function: the predicted S. pombe scn1 protein contains a TatD related DNAse domain (aa 19-357, PF01026),a feature of a large superfamily of metalloenzymes.; Remark: the S. cerevisiae homolog of S. pombe scn1 is YMR262W.; Title: strong similarity to hypothetical protein scn1p - Schizosaccharomyces pombe; See PMID 7798319
An01g02690	Remark: information regarding S. cerevisiae ICT1 has not yet been published and is available from SGD and MIPS.; Similarity: the predicted A. niger protein shows similarity to S. cerevisiae ICT1, disruption of ICT1 leads to enhanced sensitivity to benomyl and azoles.; Title: strong similarity to hypothetical protein SPAC6G10.03c - Schizosaccharomyces pombe
An01g02700	Title: similarity to hypothetical protein SPBC902.03 - Schizosaccharomyces pombe
An01g02720	Complex: the six S. cerevisiae MCM proteins (MCM2-7) interact with each other to form predominantly a hexameric complex containing all six MCM proteins but also other smaller subcomplexes.; Function: S. cerevisiae MCM3 is a helicase subunit involved in DNA replication initiation, DNA unwinding and in the pre-replicative complex formation and its maintenance.; Similarity: the predicted A. niger protein contains a MCM 2/3/5 domain (aa 110-664, PF00493) which is a component of proteins required for the initiation of DNA replication.; Title: strong similarity to replication helicase subunit Mcm3 - Saccharomyces cerevisiae; nucleus; See PMID 2233713; See PMID 9427284; See PMID 10980206
An01g02730	Remark: the C. lindemuthianum CIH1 is a fungal glycoprotein specifically located at the biotrophic interface formed in the Colletotrichum lindemuthianum-bean interaction.; Title: similarity to proline-rich glycoprotein CIH1 - Colletotrichum lindemuthianum; plasma membrane; See PMID 9721685
An01g02740	Catalytic activity: the A. oryzae tannase converts digallate and H(2)O to 2 gallate.; Remark: an alternate name for tannase is tannin hydrolase and tannin acetylhydrolase.; Remark: tannase is an esterase that hydrolyses the acyl esters of tannins, making tannins more soluble at a lower temperature and pH.; Remark: the ORF shows strong similarity to patent JP08080196-A in PATENTPROT:AAR93195.; Title: strong similarity to tannase precursor from patent JP08080196-A - Aspergillus oryzae; See PMID 8917102
An01g02750	Title: weak similarity to hypothetical protein CAC28656.1 - Neurospora crassa
An01g02760	Title: weak similarity to killer toxin Khr -Saccharomyces cerevisiae; See PMID 1368554
An01g02770	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g02790	Function: a N. crassa cya-5 mutant contains coxI mRNA but the COXI protein could not be detected. The CYA-5 protein of N. crassa is required in a post-transcriptional step for COXI expression, most probably for the efficient translation of coxI mRNA.; Localization: CYA-5 is a nuclear encoded protein. A mitochondrial targeting sequence at its amino-terminus suggests a mitochondrial localization.; Title: strong similarity to COXI translation protein CYA-5 - Neurospora crassa; See PMID 9342407
An01g02800	Complex: the signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.; Function: the signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7s RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.; Title: strong similarity to signal recognition particle 68K protein SRP68 - Canis lupus; cytoplasm; See PMID 1702390; See PMID 6292236; See PMID 8388879
An01g02810	Cofactor: Heme.; Function: Erg5 is a cytochrome P450 involved in C-22 denaturation of the ergosterol side-chain.; Pathway: S. cerevisiae Erg5 is involved in the Ergosterol biosynthesis.; Remark: alternate names for S. cerevisiae Erg5: Cyp61, YMR015c.; Similarity: S. cerevisiae Erg5 belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 sterol delta22-desaturase Erg5 - Saccharomyces cerevisiae; See PMID 7791529; See PMID 8635732; See PMID 331007; See PMID 10390230
An01g02830	Title: similarity to heat shock protein 67B2 -Drosophila melanogaster; See PMID 2454316
An01g02840	Function: IF2 is a translation factor that catalyzes the binding of initiator methionyl-tRNA to the ribosomal P site.; Title: strong similarity to translation initiation factor IF2 - Homo sapiens; See PMID 10200264
An01g02860	Title: similarity to hypothetical protein SPBC651.03c - Schizosaccharomyces pombe
An01g02870	Title: similarity to hypothetical protein SPAC227.06 - Schizosaccharomyces pombe
An01g02880	Title: strong similarity to cytoplasmic ubiquitin / ribosomal fusion protein Cep52 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift
An01g02890	Complex: forms a complex with the other RRN proteins RRN6 and RRN11.; Function: involved in the transcription of 35S rRNA genes by the core domain of RNA polymerase I.; Title: similarity to protein Rrn7 - Saccharomyces cerevisiae; See PMID 7958901; See PMID 8887672
An01g02900	Function: Translation intitiation factor eIF-5A (previously named eIF-4D) is a highly conserved protein that promotes formation of the first peptide bond. One of its lysine residues is posttranslationally modified by spermidine to form hypusine. eIF-5a is essential for cell growth in yeast cells.; Title: strong similarity to translation initiation factor Eif-5a.2 - Saccharomyces cerevisiae; See PMID 1903841
An01g02910	Title: strong similarity to hypothetical ARE1-like protein F3I17.5 - Arabidopsis thaliana
An01g02920	Title: similarity to hypothetical protein PA5145 -Pseudomonas aeruginosa
An01g02930	Title: similarity to hypothetical protein encoded by An12g09280 - Aspergillus niger
An01g02940	Remark: the similarity is restricted to the C2H2-type zinc finger motif.; Title: weak similarity to regulator protein Mhy1 -Yarrowia lipolytica
An01g02950	Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An01g02960	Catalytic activity: homogentisate + o(2) = 4-maleylacetoacetate.; Pathway: The HmgA protein catalyzes an essential step in phenylalanine catabolism.; Remark: defects in homogentisate dioxygenase are the cause of alkaptonuria, an autosomal recessive error of metabolism which is characterized by an increase in the level of homogentisic acid.; Title: strong similarity to 3,4-dihydroxyphenylacetate 2,3-dioxygenase hmgA - Aspergillus nidulans; See PMID 7673153
An01g02970	Function: PcaB confers the ability to use 4-hydroxybenzoate or protocatechuate as the only carbon source. Hydroxyaromatics catabolism by pcaB serves both nutritional and detoxifying purposes.; Title: strong similarity to 3-carboxy-cis,cis-muconate cycloisomerase pcaB - Bradyrhizobium japonicum; See PMID 9582432
An01g02980	Title: similarity to hypothetical protein CG7415 -Drosophila melanogaster
An01g03000	Title: strong similarity to hypothetical succinyl-CoA:3-ketoacid-CoA transferase SCOT - Homo sapiens
An01g03030	Catalytic activity: multiple catalytic activities of TDH: as tartrate dehydrogenase catalyzes the oxidation of (R,R)-tartrate to oxaloglycolate by NAD+ and enables the organism to grow with tartrate as the sole carbon source; as D-malate dehydrogenase catalyzes the oxidative decarboxylation of D-malate to pyruvate and carbon dioxide by NAD+; as tartrate decarboxylase catalyzes the decarboxylation of meso-tartrate to D-glycerate and carbon dioxide.; Title: strong similarity to tartrate dehydrogenase TDH - Pseudomonas putida; See PMID 2184888; See PMID 8053675
An01g03040	Similarity: the ORF shows similarity to some transcription factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans
An01g03050	Function: The poly(A)-binding protein (PABP) is the major mRNA-binding protein in eukaryotes, and it is essential for viability of the yeast S. cerevisiae.; Localization: The nuclear protein appears to be derived from the cytoplasmic one by proteolytic cleavage into 53 and 17 kd polypeptides.; Remark: The proteins has four tandemly arrayed 90 amino acid regions of homology that probably represent poly(A)-binding domains.; Title: similarity to polyadenylate-binding protein Pabp - Saccharomyces cerevisiae; See PMID 3537727; See PMID 1675426
An01g03060	Function: pub1 (protein ubiquitin ligase 1) catalyzes the attachment of the small protein ubiquitin to proteins such as the mitotic activating tyrosine phosphatase cdc25 thus specifically marking them for degradation by proteasomes.; Title: similarity to ubiquitin protein ligase ub1p -Schizosaccharomyces pombe; See PMID 8635463; See PMID 9197411
An01g03070	Title: similarity to mitochondrial ribosomal protein Yml27 - Saccharomyces cerevisiae; See PMID 1764528
An01g03080	Title: strong similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe
An01g03090	Catalytic activity: hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans.; Function: Gel1 of A. fumigatus has a role in cell wall biosynthesis.; Localization: Gel1 of A. fumigatus is anchored to the plasma membrane via a glycosylphosphatidylinositol linkage.; Remark: Gel1 of A. fumigatus was originally called ENGL1.; Remark: the official name for 1,3-beta-glucanosyltransferase is glucan endo-1,3-beta-D-glucosidase.; Similarity: Gel1 of A. fumigatus belongs to family 72 of glycosylhydrolases.; Title: strong similarity to 1,3-beta-glucanosyltransferase gel1 - Aspergillus fumigatus; plasma membrane; See PMID 9846753; See PMID 10769178; See PMID 10809732
An01g03100	Function: HUM1 is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.; Remark: A single nucleotide change in the MNR1 gene determines resistance to manganese in S. cerevisiae. MNR1 was shown to correspond to HUM1, which determines a vacuolar membrane protein.; Title: strong similarity to manganese resistance protein 1 Mnr1 - Saccharomyces cerevisiae; See PMID 8668190; See PMID 10219995
An01g03110	Title: similarity to ribosomal protein of the small subunit Rsm7 - Saccharomyces cerevisiae
An01g03120	Function: a synthetic lethal phenotype was observed in S. cerevisiae when additional to Pho90 four other phosphate transporters were inactivated.; Remark: the identical protein match in the patent database uses wrong codes and descriptions.; Title: strong similarity to phosphate transport protein Pho90 - Saccharomyces cerevisiae; plasma membrane; See PMID 11779791
An01g03130	Remark: Protein is rich in proline, glutamine and glutamatic acid.; Title: weak similarity to surface protein PspC -Streptococcus pneumoniae
An01g03140	Remark: unspecific blast hits are due to the low complexity sequence of the ORF.; Title: weak similarity to hypothetical protein encoded by An12g10460 - Aspergillus niger
An01g03150	Title: strong similarity to hypothetical protein EAA66565.1 - Aspergillus nidula
An01g03160	Complex: S8 is one of the protein constituents of the 40S subunit of eucaryotic ribosomes.; Function: involved in eucaryotic protein synthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit S8 - Rattus norvegicus; cytoplasm; See PMID 3684599; See PMID 8910435
An01g03170	Title: similarity to hypothetical protein CG16717 -Drosophila melanogaster
An01g03180	Function: Drosophila Mbc encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization.; Pathway: It is suggested that Mbc is a specific upstream regulator of the activity of the GTPase Rac that mediates several morphogenetic processes in Drosophila embryogenesis.; Title: similarity to myoblast city protein Mbc -Drosophila melanogaster; See PMID 9245788; See PMID 9808621
An01g03190	Function: SEC3 is one of ten SEC genes required for targeting or fusion of post-Golgi secretory vesicles to the plasma membrane in S. cerevisiae. It is suggested that polarized secretion would result from the coupling of actin-dependent vesicle targeting with SEC3-dependent establishment of the vesicle fusion site.; Title: similarity to protein Sec3 - Saccharomyces cerevisiae; plasma membrane; See PMID 9247645; See PMID 9491896
An01g03200	Remark: Incorporated choline is exclusively utilized for the synthesis of phosphatidylcholine.; Title: similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 2203793
An01g03210	Function: NADPH:protochlorophyllide oxidoreductase (POR) catalyses the light-dependent reduction of protochlorophyllide to chlorophyllide, a key reaction in the chlorophyll biosynthetic pathway.; Localization: POR is a peripheral protein located on the stromal side of the thylakoid membrane.; Title: similarity to proteophosphoglycan ppg3 -Pisum sativum; See PMID 7579182; See PMID 9224639
An01g03220	Remark: the systematic name of Upc2 from S. cerevisiae is YDR213w.; Title: similarity to hypothetical RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae
An01g03230	Similarity: the similarities are due to repetetive sequences.
An01g03240	Title: weak similarity to hypothetical protein B23I11.30 - Neurospora crassa
An01g03250	Pathway: TRI4 of Fusarium sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: TRI4 has been placed in a new cytochrome P450 gene family designated CYP58.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An01g03260	Title: similarity to hypothetical mitochondrial ribosomal protein of the small subunit S37 - Saccharomyces cerevisiae
An01g03270	Title: strong similarity to hypothetical conserved protein B24M22.130 - Neurospora crassa
An01g03280	Remark: C-terminally truncated due to contig border.; hypothetical protein [truncated ORF]
An01g03290	Remark: no start codon due to end of contig.; Title: weak similarity to hypothetical lipoprotein nlpD - Synechocystis sp. [truncated ORF]
An01g03300	Function: E. coli iucB functions as N epsilon-hydroxylysine:acetyl coenzyme A N epsilon-transacetylase involved in biosynthesis of aerobactin.; Function: E. coli iucB is involved in iron uptake through biosynthesis of the low molecular weight iron specific chelator (siderophore) aerobactin, a hydroxamate compound.; Regulation: expression of E. coli iucB is iron dependent.; Title: strong similarity to siderophore synthesizing acetylase iucB - Escherichia coli [putative frameshift]; putative frameshift; See PMID 2935523; See PMID 2973985; See PMID 4313071
An01g03310	Function: human Crym is a NADP-regulated thyroid hormone receptor.; Localization: human Crym was purified from cytosol.; Similarity: human Crym shows similarity to bacterial lysine cyclodeaminase and ornithine cyclodeaminase.; Title: similarity to thyroid hormone-binding protein mu-crystallin Crym - Homo sapiens; cytoplasm; putative frameshift
An01g03330	Complex: interaction of A. nidulans pclA with a PSTAIRE kinase was shown in vivo.; Function: A. nidulans pclA might mediate cell cycle events during late stages of sporulation.; Function: mutations of A. nidulans pclA show reduced production of conidia.; Induction: in A. nidulans expression of pclA was strongly induced by ectopic expression of brlA or abaA under conidiation-suppressing conditions.; Title: strong similarity to Pcl-like cyclin pclA -Aspergillus nidulans; See PMID 11359914
An01g03340	Function: A. aculeatus xyloglucan-specific endo-beta-1,4-glucanase hydrolyzes structurally diverse xyloglucans from various sources, but hydrolyzes no other cell wall component.; Title: strong similarity to xyloglucan-specific endo-beta-1,4-glucanase - Aspergillus aculeatus; See PMID 9884411
An01g03350	Function: N. crassa erg-1 is involved in the terminal steps of ergosterol biosynthesis, catalysing deltaC8 -> deltaC7 isomerisation.; Title: strong similarity to C-8 sterol isomerase erg-1 - Neurospora crassa; See PMID 154056
An01g03360	Title: strong similarity to hypothetical protein SPBC2G5.03 - Schizosaccharomyces pombe
An01g03370	Function: D. discoideum aimless is involved in the processing of chemotactic signals through G-protein-coupled receptors.; Function: mutations in D. discoideum aimless impaire both chemotaxis and activation of adenylyl cyclase.; Title: similarity to aimless RasGEF aleA -Dictyostelium discoideum; See PMID 8793298
An01g03390	Title: weak similarity to hypothetical protein CAD21197.1 - Neurospora crassa
An01g03400	Remark: alternative names for S. cerevisiae ARG81 are ARGR2 and YML099C.; Similarity: similarity is between the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing N-terminal regions of the predicted A. niger protein and S. cerevisiae ARG81, which is 300 aa longer.; Similarity: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to transcription factor Arg81 - Saccharomyces cerevisiae; nucleus
An01g03410	Function: S. cerevisiae Nfu1 has been implicated in mitochondrial Fe/S cluster assembly.; Function: mutations in S. cerevisiae nfu1 lead to decrease in activity of Fe/S containing mitochondrial proteins and mitochondrial iron accumulation.; Localization: S. cerevisiae Nfu1 is located in the mitochondrial matrix.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2888 and 1706.; Remark: the systematic name for S. cerevisiae NFU1 is YKL040c.; Title: strong similarity to Fe/S cluster assembly factor Nfu1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10468587; See PMID 11171977
An01g03440	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An01g03450	Function: overepression of S. cerevisiae PSP1 suppresses the temperature sensitivity of mutations in DNA-Pol1, DNA-Pol3 and the DNA-replication initation factor CDC6.; Title: similarity to suppressor of DNA-Pol1 mutations Psp1 - Saccharomyces cerevisiae; See PMID 9529527
An01g03460	Gene-ID: rpl15; Remark: informations regarding A. niger rp115 has not yet been published and is available from Swissprot and EMBL.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1657.; Similarity: the aa sequences of A. niger rp115 and S. cerevisiae RPL15 are nearly identical.; cytoplasm; See PMID 6814480
An01g03470	Function: human E6-AP is a ubiquitin-protein ligase (E3) implicated in p53 inactivation.; Title: strong similarity to ubiquitin protein ligase E6-AP - Homo sapiens; See PMID 8221889; See PMID 11265246
An01g03480	Catalytic activity: L-iditol 2-dehydrogenases convert L-iditol + NAD(+) to L-sorbose + NADH.; Remark: a splice site upstream of the start codon was detected.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0571, 2665, 2264, 2244, 1618 and 0775.; Title: strong similarity to sorbitol dehydrogenase gutB - Bacillus subtilis
An01g03490	Title: strong similarity to hypothetical protein CAE76442.1 - Neurospora crassa
An01g03500	Remark: RZF of S. pombe is also called SPBC15C4. 06c.; Similarity: the ORF shows similarity to RZF only along a stretch of about 200 amino acids.; Similarity: the ORF shows strong similarity to the A. niger EST EMBLEST:BE760008 an_2963.; Similarity: the predicted A. niger protein contains a RING zinc finger DNA-binding motif and shows similarity to the RING zinc finger domains of several cDNAs.; Title: similarity to hypothetical serine-rich zinc-finger protein RZF - Schizosaccharomyces pombe
An01g03510	Complex: S. cerevisiae ADA3 is part of the ADA and SAGA histone acetyltransferase complexes which also contain Spt, Ada2, Gcn5 and, ADA specific, Ahc1.; Function: S. cerevisiae ADA3 is an adapter protein within the ADA and SAGA histone acetyltransferase complex.; Title: strong similarity to ADA and SAGA histone acetyltransferase subunint Ada3 - Saccharomyces cerevisiae; nucleus; See PMID 10490601
An01g03520	Function: it has been suggested that S. cerevisiae NPR2 is a post-transcriptional regulator of nitrogen permeases.; Regulation: S. cerevisiae NPR2 mRNA is not down-regulated under nitrogen catabolite repression, and is induced by urea and proline.; Title: similarity to nitrogen permease regulator Npr2 - Saccharomyces cerevisiae; See PMID 7867803
An01g03540	Similarity: similarity is between the N-terminal regions of the predicted A. niger protein to human artemis.; Title: similarity to DNA double-strand break repair/V(D)J recombination protein artemis - Homo sapiens; See PMID 11336668
An01g03550	Catalytic activity: ureases convert urea + H(2)O to CO(2) + 2 NH(3).; Title: strong similarity to urease URE1 -Cryptococcus neoformans; See PMID 10639402
An01g03560	Complex: S. cerevisiae HMO1 binds single-stranded DNA and associates with a 5' to 3' DNA helicase activity.; Function: S. cerevisiae HMO1 is a single-stranded DNA binding protein that associates with a 5' to 3' DNA helicase activity in nuclear extracts.; Function: S. cerevisiae HMO1 may play a general role in controlling chromatin structure and perhaps a specific role in controlling transcription and DNA replication.; Remark: the coding region might be N-terminal truncated due to border of contig.; Remark: the systematic name for S. cerevisiae HMO1 is YDR174w.; Title: similarity to chromatin-associated protein Hmo1 - Saccharomyces cerevisiae; nucleus; See PMID 8969238
An01g03570	Catalytic activity: cytochrome-b5 reductases convert NADH + 2 ferricytochrome b5 to NAD(+) + 2 ferrocytochrome b5.; Function: S. cerevisiae MCR1 plays an important role in the response to oxidative damage.; Localization: S. cerevisiae MCR1 is inserted into the outer mitochondrial membrane, where 1/3 becomes firmely anchored at the outer surface while the rest is released into the intermembrane space after proteolytic cleavage in the inner membrane.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_2939.; Title: strong similarity to cytochrome-b5 reductase Mcr1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8001120; See PMID 11420140
An01g03580	Remark: alternative names for S. cerevisiae RPL20 are RPL18A2 and YMR242C.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3214, 0548, 1747, 3000, 3600, 3406, 2063 and 0732.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L18a Rpl20 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 10404161
An01g03590	Title: strong similarity to peptidase HPEP-6 from patent WO200042201-A2 - Homo sapiens
An01g03600	Title: weak similarity to casein kinase 1 cki1p -Schizosaccharomyces pombe
An01g03610	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2008.; Title: strong similarity to hypothetical zf-C3HC4 zinc finger protein - Schizosaccharomyces pombe
An01g03630	Complex: S. cerevisiae STB1, STB2 and SIN3 are components of a large multiprotein complex.; Complex: in a two-hybrid screen S. cerevisiae STB2 binds the transcriptional repressor SIN3 which has no DNA binding activity.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and S. cerevisiae STB2.; Title: strong similarity to Sin3p binding protein Stb2 - Saccharomyces cerevisiae; nucleus; See PMID 9234741; See PMID 9393435
An01g03640	Complex: in S. cerevisiae the TIM10 complex can be formed exclusively from Tim9 and Tim10.; Complex: in S. cerevisiae the TIM10 complex is a member of the Tim18p-Tim22p-Tim54p membrane complex.; Function: the S. cerevisiae TIM10 complex functions as a putative chaperone to guide hydrophobic precursors across the intermembrane space.; Function: the S. cerevisiae TIM10 complex is a member of the Tim18p-Tim22p-Tim54p membrane complex that mediates precursor insertion into the membrane.; Function: the S. cerevisiae TIM10 complex is required for import of the ADP/ATP carrier (AAC) into mitochondria.; Localization: in S. cerevisiae the soluble TIM10 complex localises in the mitochondrial intermembrane space while as part of a larger complex it localises to the membrane.; Remark: an alternative name for S. cerevisiae TIM10 is MRS11.; Title: strong similarity to mitochondrial import factor Tim10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11483513; See PMID 11509656
An01g03650	Catalytic activity: lysine-tRNA ligase convert ATP + L-lysine + tRNA(Lys) to AMP + diphosphate + L-lysyl-tRNA(Lys).; Title: strong similarity to cytosolic lysine--tRNA ligase Krs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2903861
An01g03660	Similarity: the ORF shows strong similarity to EST 5419 - Aspergillus oryzae.; Title: similarity to hypothetical protein T9E8.140 -Arabidopsis thaliana
An01g03670	Similarity: the similarities are mainly due to repetetive sequences.; Title: strong similarity to hypothetical protein EAA66525.1 - Aspergillus nidulans
An01g03680	Complex: mouse ALDR must form a homo- or heterodimer to be functional.; Similarity: mouse ALDR is a ABC half transporter containing one transmembrane domain and a single ATP-binding fold while functional ABC-tansporter comprise two transmembrane and two ATP-binding domains.; Title: strong similarity to peroxisomal ABC transporter ALDR - Mus musculus; peroxisome; See PMID 8577752; See PMID 10504404
An01g03690	Title: weak similarity to toxin subunit 1 TOX S1 -Bordetella pertussis; See PMID 2873570
An01g03700	Function: PSR1 of S. cerevisiae is a membrane-linked protein phosphatase involved in response to sodium stress,together with the homologue PSR2.; Phenotype: growth of the PSR1/PSR2 mutant is severely inhibited under conditions of sodium stress, due to the inability to properly induce transcription of ENA1/PMR2, the major sodium extrusion pump of yeast cells.; Remark: PSR1 of S. cerevisiae is also called YLL010c.; Similarity: the N-terminal region of the predicted ORF shows no significant similarity.; Title: strong similarity to phosphatase Psr1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10777497
An01g03720	Function: SDS22 of S. cerevisiae is essential for the mitotic metaphase/anaphase transition, positively modulating protein phosphatase-1.; Remark: SDS22 of S. cerevisiae is also called EGP1 or YKL193c.; Title: strong similarity to protein phosphatase type1 regulatory subunit Sds22 - Saccharomyces cerevisiae; nucleus; See PMID 9584086; See PMID 10775415; See PMID 7791784; See PMID 7791785
An01g03730	Remark: the gene model was extracted to fill an intergenic region; the N-terminal part of the predicted ORF overlaps to the 3'UTR of the A. niger xyrA gene.; Title: questionable ORF
An01g03740	Function: D-xylose reductase catalyses the NADPH-dependent reduction of D-xylose to xylitol, which is the first step in D-xylose catabolism in fungi.; Gene-ID: xyrA; Induction: xyrA is under the transcriptional control of XlnR, a major transcription factor involved in the degradation of the polysaccharides xylan and cellulose.; See PMID 10760176
An01g03750	Function: A. nidulans brlA, abaA, and wetA form a dependent pathway that regulates asexual reproductive development.; Function: in A. nidulans, expression of abaA in vegetative cells does not result in conidial differentiation but does lead to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization.; Title: strong similarity to protein abaA -Aspergillus nidulans; See PMID 2655931
An01g03760	Similarity: the presence of RNA binding domains suggests a role in RNA processing.; Title: strong similarity to hypothetical protein pi029 - Schizosaccharomyces pombe
An01g03770	Complex: dynein consists of at least two heavy chains and a number of intermediate and light chains.; Function: dynein is involved in intracellular transport and motility, and plays a role in changing or maintaining the spatial distribution of cytoskeletal structures.; Similarity: the predicted ORF is almost identical to the 8 kDa cytoplasmic dynein light chain NUDG of Aspergillus nidulans, whose characterization has not been published.; Title: strong similarity to dynein light chain 1 cdlc1 - Drosophila melanogaster; See PMID 8628263; See PMID 11212346
An01g03780	Similarity: the patented EST covers the last two exons and part of the putative 3'-UTR.; Title: strong similarity to EST SEQ ID NO:4125 from patent WO200056762-A2 - Aspergillus niger
An01g03790	Function: DUR3 is a component required for active transport of urea in S. cerevisiae.; Similarity: DUR3 of S. cerevisiae is a member of the major facilitator superfamily (MFS) of transport proteins.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 7867803; See PMID 8335627; See PMID 8720066
An01g03810	Similarity: the HIT (histidine triad) region binds one zinc ion in proteins lacking zinc fingers; the domain is poorly conserved in the predicted ORF.; Similarity: the N-terminal part of the predicted protein produces some BLASTP hits due to the high content of low-complexity regions.; Title: similarity to hypothetical HIT-like protein -Rhodococcus sp.
An01g03820	Complex: SBH2 of cerevisiae interacts with SSH1 and SSS1; the complex is involved in protein translocation into the endoplasmic reticulum.; Remark: SBH2 of S. cerevisiae is also known as SEB2 or YER019C.; Similarity: strong similarity to A. oryzae EST PATENTDNA:AAF12808, which confirms the structure of exons 2 and 3.; Title: strong similarity to ER protein-translocation complex subunit Sbh2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8612571; See PMID 8740416; See PMID 10921929
An01g03870	Title: strong similarity to hypothetical protein SPAC23H3.04 - Schizosaccharomyces pombe
An01g03880	Title: strong similarity to EST an_1234 -Aspergillus niger
An01g03900	Function: AtrA of A. nidulans is an ABC transporter,and can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695
An01g03930	Function: pcn1 of S. pombe is involved in nucleic acid metabolism and cell-cycle control.; Function: pcn1 of S. pombe seems to encircle DNA and tether the polymerase to the DNA template for processive DNA synthesis.; Title: strong similarity to proliferating cell nuclear antigen pcn1p - Schizosaccharomyces pombe; nucleus; See PMID 10449724; See PMID 1361173
An01g03940	Title: strong similarity to hypothetical protein EAA64320.1 - Aspergillus nidulans
An01g03950	Title: strong similarity to hypothetical protein CAE76289.1 - Neurospora crassa
An01g03960	Title: weak similarity to hypothetical kinesin-like protein klp-7 - Caenorhabditis elegans
An01g03970	Similarity: the C-terminal part shows strong similarity to D. melanogaster asp, mammalian plectins and dystonin, all proteins involved in cytoskeletal organization, in different cellular compartments and functional contexts.; Similarity: the N-terminal part shows a weaker similarity to X. laevis nucleolar phosphoprotein xNopp180,involved in nuclear localization signal binding, which shuttles between the nucleolus and the cytoplasm.; Similarity: the predicted protein shows different similarities in the N-terminal and C-terminal halves.; Title: similarity to microtubule-associated protein asp - Drosophila melanogaster; See PMID 9151690; See PMID 7593294
An01g03980	Title: questionable ORF
An01g03990	Similarity: very weak similarity to a putative protein kinase of Myxococcus xanthus, that has a totally different length.
An01g04010	Title: weak similarity to protein fragment SEQ ID NO:5110 from patent EP1033405-A2 - Zea mays
An01g04030	Similarity: the inner part of the predicted ORF shows some similarity to the C-terminal half of the hypothetical protein SPCC1259. 08 of S. pombe.; Title: weak similarity to hypothetical protein SPCC1259.08 - Schizosaccharomyces pombe
An01g04040	Function: sarA of A. nidulans is involved in the secretion of proteins, probably as a component of COPII coat of vesicles, that facilitate the transport from the ER to the Golgi by vesicle budding.; Gene-ID: sarA; Phenotype: three mutant alleles of the A. niger sarA gene (D29G, E109K, D29G/E109K), generated by site-directed mutagenesis, revealed a thermosensitive dominant-negative phenotype in the presence of the wild-type sarA allele.; Similarity: the sequence of the predicted ORF is different to the published translation of the A. niger sarA gene at positions C102R, D141E and V142L.; See PMID 8889833; See PMID 9756629
An01g04050	Function: bimG of A. nidulans is required for the completion of anaphase by reversing the action of the nimA kinase.; Phenotype: a mutation in bimG of A. nidulans causes an abnormally high content of nuclear phosphoproteins.; Phenotype: the temperature-sensitive, recessive cell cycle mutation A. nidulans bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Remark: the N-terminal part of the ORF is found on ORF An01g04060.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans [truncated ORF]
An01g04060	Function: TFC4 of S. cerevisiae is a subunit of transcription factor tau (TFIIIC) involved in tRNA and 5SRNA gene transcription; TFC4 acts as assembly factor,which recruits the initiation factor, TFIIIB, to the DNA.; Remark: TFC4 of S. cerevisiae is also called YGR047C or pcf1.; Title: strong similarity to assembling subunit of transcription factor IIIC Tfc4 - Saccharomyces cerevisiae; nucleus; See PMID 2686985
An01g04070	Remark: the predicted ORF is only 62 amino acids long.; Title: questionable ORF
An01g04080	Similarity: the similarity of the predicted ORF to the hypothetical protein YOR359w of S. cerevisiae is restricted to the C-terminal end of both proteins, but the homology in this region is relatively high.; Title: similarity to hypothetical protein YOR359w -Saccharomyces cerevisiae
An01g04100	Function: mdr of B. subtilis is a multidrug-efflux transporter for e. g. puromycin, nerfloxacin and tosufloxa.; Similarity: the ORF shows strong similarity to several multidrug-efflux transporters (especially from bacteria) with different specificities.; Title: strong similarity to multidrug resistance protein MDR - Bacillus subtilis; See PMID 1675788; See PMID 11378963
An01g04110	Function: SutB of P. chrysogenum is the major sulfate permease involved in sulfate uptake by P. chrysogenum.; Function: in industrial fermentations, P. chrysogenum uses sulfate as the source of sulfur for the biosynthesis of penicillin.; Phenotype: disruption of P. chrysogenum sutB resulted in a loss of sulfate uptake ability.; Remark: the N-terminal half of the homolog to SutB of P. chrysogenum is located in ORF An01g04210.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum [truncated ORF]
An01g04120	Function: bimG of A. nidulans is required for the completion of anaphase by reversing the action of the nimA kinase.; Phenotype: a mutation in bimG of A. nidulans causes an abnormally high content of nuclear phosphoproteins.; Phenotype: the temperature-sensitive, recessive cell cycle mutation A. nidulans bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Remark: the C-terminal part of the ORF is found on ORF An01g04050.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans [truncated ORF]
An01g04140	Remark: the EST of A. niger can be found in EMBLEST:BE759969.; Similarity: the alignment of the predicted ORF sequence with the A. niger EST shows some gaps and missmatches.; Title: similarity to EST an_2919 - Aspergillus niger
An01g04150	Similarity: the predicted ORF is 148 amino acids longer than the hypothetical protein SPAC926. 06c of S. pombe.; Title: strong similarity to hypothetical protein SPAC926.06c - Schizosaccharomyces pombe
An01g04160	Remark: the intron-exon structure for the predicted ORF is suboptimal.
An01g04170	Remark: the predicted intron-exon structure of the ORF is not optimal.
An01g04180	Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759732) an_2635.; Similarity: the predicted ORF is 119 amino acids longer than the hypothetical protein SPAC31G5. 20c of S. pombe.; Title: strong similarity to hypothetical protein SPAC31G5.20c - Schizosaccharomyces pombe
An01g04190	Remark: the predicted ORF is only 54 amino acids long.; Title: questionable ORF
An01g04200	Remark: the predicted ORF is only 30 amino acids long.; Title: questionable ORF
An01g04210	Function: SutB of P. chrysogenum is the major sulfate permease involved in sulfate uptake by P. chrysogenum.; Function: in industrial fermentations, P. chrysogenum uses sulfate as the source of sulfur for the biosynthesis of penicillin.; Phenotype: disruption of P. chrysogenum sutB resulted in a loss of sulfate uptake ability.; Remark: the C-terminal half of the homolog to SutB of P. chrysogenum is located on An01g04200.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum [truncated ORF]
An01g04230	Title: strong similarity to hypothetical WD-repeat transcription regulation protein SPCC18.13 -Schizosaccharomyces pombe
An01g04240	Remark: P0 of S. cerevisiae belongs to the family of rat acidic ribosomal proteins P0.; Remark: P0 of S. cerevisiae is also called A0,L8300. 8, YLR340w and ribosomal protein YL10e.; Similarity: the ORF overlaps with the EST seq id NO:3822 of patent WO200056762-A2 from A. niger.; Title: strong similarity to cytoplasmic acidic ribosomal protein P0 - Saccharomyces cerevisiae; cytoplasm; See PMID 2681177; See PMID 3287327
An01g04250	Catalytic activity: Uroporphyrinogen-III <=> coproporphyrinogen + 4 CO(2).; Function: the T. terrestris homolog catalyzes the sequential decarboxylation of the four acetyl side chains of uroporphyrinogen to yield coproporphyrinogen, an intermediate in protoheme biosynthesis.; Title: strong similarity to uroporphyrinogen decarboxylase from patent WO9925839-A1 - Thielavia terrestris; cytoplasm
An01g04260	Catalytic activity: cytosine + H(2)O <=> uracil + NH(3).; Remark: strong similarity to cytosine deaminase FCA1 - Candida albicans.; Title: strong similarity to cytosine deaminase FCA1 - Candida albicans; See PMID 9000374
An01g04270	Title: similarity to EST SEQ ID NO:4107 from patent WO200056762-A2 - Aspergillus niger
An01g04280	Function: Haploid S. cerevisiae cells carrying the disrupted YDJ1 gene are inviable for growth in liquid media.; Function: YDJ1p from S. cerevisiae is involved mitochondrial and ER import.; Function: YDJ1p from S. cerevisiae is required for normal growth and disruption of its gene results in very slow growing cells that have pleiotropic morphological defects.; Localization: YDJ1p from S. cerevisiae cofractionates with nuclei and also microsomes, suggesting that its perinuclear localization reflects association with the ER.; Remark: has similarity to family of dnaJ heat shock proteins.; Remark: synonyms for Ydj1 from S. cerevisiae are Mas5 and YNL064c.; Similarity: the ORF also shows strong similarity to expressed sequence tag seq id no:6895 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to dnaJ protein homolog Ydj1 - Saccharomyces cerevisiae; cytoplasm; See PMID 11014801; See PMID 11689685
An01g04300	Title: strong similarity to protein fragment SEQ ID NO:54638 from patent EP1033405-A2 - Arabidopsis thaliana
An01g04310	Function: the S. pombe homolog Mex67p participates at various common steps with Rae1p export complexes in promoting the nuclear cytoplasmic export of mRNA.; Similarity: S. pombe Mex67p has similarity to the human mRNA export factor Tap.; Title: strong similarity to mRNA export factor mex67p - Schizosaccharomyces pombe; nucleus
An01g04320	Complex: part of the Erv41p-Erv46p subcomplex associated with the COPII vesicle coat.; Function: S. cerevisiae Erv46p is involved in ER to Golgi vesicle transport.; Remark: a splice site upstream of the start codon was detected.; Remark: alternative gene names for the S. cerevisiae homolog ERV46 are FUN9 and YAL042W.; Title: strong similarity to COPII vesicle coat component protein Erv46 - Saccharomyces cerevisiae; intracellular transport vesicles
An01g04330	Title: strong similarity to hypothetical protein YLR187w - Saccharomyces cerevisiae
An01g04370	Function: the C. albicans homolog CATFIIIA is involved in initiating transcription of the ribosomal RNA 5S gene.; Similarity: C. abicans CATFIIIA belongs to the superfamily of transcription factor IIIA proteins.; Title: strong similarity to transcription factor CATFIIIA from patent WO200028037-A1 - Candida albicans; nucleus
An01g04380	Complex: S. cerevisiae Rpo26p is essential for the assembly of RNA polymerase I and RNA polymerase II and for the stability of the largest subunits of these enzymes.; Function: the S. cerevisiae homolog RPO26 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Title: strong similarity to 23 kD subunit of DNA-directed RNA polymerase I,II,III Rpo26 - Saccharomyces cerevisiae; nucleus
An01g04400	Similarity: has similarity to the monocarboxylate transporters of the major facilitator superfamily.; Title: strong similarity to hypothetical protease Mch5 - Saccharomyces cerevisiae
An01g04410	Title: strong similarity to N-acetyl transferase NACTH from patent US6017744-A - Homo sapiens
An01g04420	Title: strong similarity to hypothetical protein CAE76116.1 - Neurospora crassa
An01g04430	Title: strong similarity to translation initiation factor eIF-3 - Schizosaccharomyces pombe; cytoplasm
An01g04440	Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: strong similarity to hypothetical conserved protein SMc00345 - Sinorhizobium meliloti
An01g04450	Catalytic activity: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.; Function: PDE9A of M. musculus and H. sapiens plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides; this phosphodiesterase has a high affinity for cGMP.; Remark: in mammals a number of isoforms of PDE9A are produced by alternative splicing.; Similarity: the predicted protein is almost twice longer as PDE9A of mammals, and the N- and C-terminal regions show no similarity.; Title: similarity to cGMP phosphodiesterase PDE9A -Mus musculus; See PMID 9624145; See PMID 9856478
An01g04470	Similarity: although some regions of the predicted protein are very similar to S. pombe SPAC3H1. 12c, other regions are absolutely not conserved.; Similarity: the predicted protein contains several structurale domains found in DNA-binding regulatory proteins, like the BAH domain, the PHD-type zinc finger and the Myb-like DNA-binding domain.; Title: similarity to hypothetical protein YGL131c -Saccharomyces cerevisiae
An01g04480	Title: weak similarity to gravin-like gl - Xenopus laevis; See PMID 11165490
An01g04520	Function: D. melanogaster mus308 encodes a theta DNA polymerase involved in DNA repair.; Function: mus308 is required in D. melanogaster to process ethyl nitrosourea (ENU) induced lesions, and may play a role in post replication bypass of O-alkylpyrimidines, probably mediated by recombination,which serves to increase the time available for error-free repair of these lesions.; Similarity: mus308 of D. melanogaster and other similar proteins are twice longer than the predicted proetin.; Title: similarity to theta DNA polymerase mus308 -Drosophila melanogaster; See PMID 8417992; See PMID 8816490; See PMID 9539982; See PMID 10343651; See PMID 10732683
An01g04530	Similarity: strong similarity to A. niger EST EMBLEST:BE760850.; Similarity: the predicted ORF does not contain structural features common to protein kinases.; Title: similarity to hypothetical MAP3K protein kinase-like protein MLD14.3 - Arabidopsis thaliana
An01g04550	Function: VPS8 of S. cerevisiae is involved in vacuolar protein sorting and required for localization and trafficking of the CPY sorting receptor.; Similarity: VPS8 of S. cerevisiae is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif.; Similarity: the predicted protein does not contain such a RING finger.; Title: strong similarity to vacuolar protein sorting-associated protein Vps8 - Saccharomyces cerevisiae; See PMID 8864656; See PMID 8969229; See PMID 9412470; See PMID 3062374
An01g04560	Function: mixed-linked glucanases (MLGases) are extracellular enzymes able to hydrolyze beta 1,3-1,4-glucans.; Similarity: the C-terminal part of the predicted protein has similarity to a calcium binding domain found e. g. in a penicillin-binding protein of Bacillus subtilis.; Similarity: the product of MLG1 of C. carbonum has no close similarity to any known protein but does contain a motif (EIDI) that occurs at the active site of MLGases from several prokaryotes; this motif is conserved in the predicted protein.; Title: strong similarity to mixed-linked glucanase precursor MLG1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9464371
An01g04570	Function: CAP10 of C. neoformans is a cytoplasmic protein required for capsule formation.; Remark: C. neoformans is a pathogenic fungus which most commonly affects the central nervous system and causes fatal meningoencephalitis primarily in patients with AIDS,and produces a thick extracellular polysaccharide capsule which is well recognized as a virulence factor.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503
An01g04590	Function: KRE33 of S. cerevisiae, also called YNL132W, is a protein extremely conserved till humans; the molecular function is unknown, but the gene is claimed to be involved in killer toxin resistance, although the results are still unpublished.; Phenotype: null mutation of KRE33 in S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein Kre33 - Saccharomyces cerevisiae
An01g04600	Function: the evidences suggesting the existence and expression of prpA in A. niger are very strong, although no function could be clearly demonstrated for the gene product.; Gene-ID: prpA; Phenotype: an A. niger strain containing a deletion of the prpA gene is viable; however, deletion of the prpA gene causes a reduction of exogenous proteins production.; Similarity: prpA is similar to protein disulfide isomerase (PDI), an enzyme important in assisting the folding and maturation of secretory proteins in eukaryotes.; See PMID 9021130; See PMID 10653750; See PMID 10672446
An01g04610	Title: similarity to hypothetical protein CAE76271.1 - Neurospora crassa
An01g04620	Function: the DnaJ-domain is part of a chaperone (protein folding) system.; Similarity: the main feature of the predicted protein is to contain a C-terminal DnaJ domain; the domain covers just 10% of the total protein lenght.; Title: weak similarity to immunogenic protein #16513 from patent WO200181581-A2 - Propionibacterium acnes
An01g04630	Complex: more in detail, ATP3 is a part of the F1 complex, a water soluble subunit which retain the ATPase activity but not the proton-transporting activity.; Function: ATP3 of S. cerevisiae is a component of the H+-transporting ATP synthase complex, a mitochondrial membrane-bound enzyme in which transport of protons is coupled with ATP synthesis.; Remark: in the gene model, a non conventional splice donor (GC instead of GT) was used in the 3' position of exon 4, due to the identity to A. niger EST SEQ ID NO:3921 of patent WO200056762-A2 and the local identity to the fungal homologues.; Title: strong similarity to gamma chain precursor of the H+-transporting ATP synthase Atp3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7929329; See PMID 9857174; See PMID 10953875; See PMID 7498726
An01g04640	Catalytic activity: ATP-independent breakage of single-stranded DNA,followed by passage and rejoining.; Catalytic activity: when a topoisomerase transiently breaks a DNA backbone bond,it simultaneously forms a protein-DNA link,in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.; Function: the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another; eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.; Similarity: the predicted protein shows very strong similarity to the A. nidulans topoisomerase, whose catalytic activity was not experimentally reported.; Title: strong similarity to topoisomerase I CaTOP1 -Candida albicans; nucleus; See PMID 9026437
An01g04650	Remark: the encoded protein also shows weak similarities to UDPglucose 4-epimerase galE from Neisseria gonorrhoeae.; Title: strong similarity to sequence SEQ ID NO:12396 from patent WO200171042-A2 - Drosophila melanogaster
An01g04670	Similarity: proline-rich regions lead to a variety of unspecific similarities.; Title: similarity to hypothetical protein F10M23.90 - Arabidopsis thaliana
An01g04680	Function: palB of A. nidulans is a factor involved in ambient pH signalling transduction pathway.; Remark: calpains are cytosolic cysteine proteases that are activated by a rise in intracellular Ca2+, and are believed to function in stimulating Ca2+ signaling.; Title: strong similarity to calpain-like protease palB - Aspergillus nidulans; cytoplasm; See PMID 7499363; See PMID 7581026
An01g04690	Function: Ant1 of S. cerevisiae is a peroxisomal transporter involved in the transport of cytoplasmic ATP into the peroxisomal lumen in exchange for AMP.; Induction: Ant1 of S. cerevisiae is induced by oleic acid.; Localization: Ant1 of S. cerevisiae is localized in the peroxisomal membrane.; Remark: ATP imported into the peroxisome is required for the activation of fatty acids.; Title: strong similarity to peroxisomal transporter Ant1 - Saccharomyces cerevisiae; peroxisome; See PMID 11566870
An01g04700	Title: weak similarity to thermostable nuclease Tnase nuch - Staphylococcus hyicus; See PMID 8045422
An01g04710	Catalytic activity: ATP + AMP = ADP + ADP.; Function: adenylate kinase is required for cell maintenance and cell growth.; Localization: adenylate kinase ADK2 from S. cerevisiae is located in the mitochindrial matrix.; Remark: ADK2 of S. cerevisiae is also known as AKY3,PAK3 and YER170W.; Similarity: adenylate kinases are highly conserved.; Title: strong similarity to adenylate kinase Adk2 -Saccharomyces cerevisiae; See PMID 9425120; See PMID 1587477; See PMID 1620094
An01g04720	Complex: eukaryotic DNA primase is a heterodimer of a large subunit (p58) and a small subunit (p48).; Function: DNA primase initiates the synthesis of new DNA strands by synthesizing short RNA oligomers on single-stranded DNA, is essential for telomere maintenance and so chromosome stability.; Title: strong similarity to DNA primase large subunit Pri2 - Saccharomyces cerevisiae; See PMID 11084371; See PMID 2528682
An01g04730	Complex: sec23 interacts with 5 other proteins,namely sec13, sec16, sec24, sec31 and sar1, to form the coat protein II - coated vesicle (COPII) complex.; Function: sec23 is required for transport of secretory, plasma membrane and vacuolar proteins from the endoplasmic reticulum to the Golgi apparatus.; Localization: sec23 is located on the cytoplasmic surface of either the cytoskeleton or the membrane.; Remark: sec23 binds directly to the C-terminus of sec16.; Similarity: sec23 is highly conserved.; Title: strong similarity to secretory protein Sec23 - Saccharomyces cerevisiae; See PMID 8930902; See PMID 1498369; See PMID 2670558
An01g04740	Remark: the ORF overlaps with A. niger EST an_2410 in EMBLEST.; Similarity: ribosomal protein L12 is highly conserved.; Title: strong similarity to ribosomal protein of the large subunit L12 - Mus musculus; See PMID 8359697
An01g04750	Remark: the ORF is a short.
An01g04760	Similarity: similarity to N-acetylglucosaminyltransferase chain p110 from R. norvegicus is only over C-terminal region.; Title: similarity to hypothetical protein B12K8.10 -Neurospora crassa
An01g04820	Remark: the ORF has an unusual exon/intron structure.
An01g04830	Function: the flbD gene from Aspergillus nidulans encodes a protein with a Myb-like DNA-binding domain that is proposed to act in concert with other developmental regulators to control initiation of conidiophore development.; Function: the flbD gene from Aspergillus nidulans is involved in the coordination of initiation of conidiophore development.; Title: strong similarity to myb-like DNA binding protein flbD - Aspergillus nidulans; nucleus; See PMID 7883170; See PMID 9539422
An01g04850	Title: weak similarity to hypothetical protein BAB09566.1 - Arabidopsis thaliana
An01g04860	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g04870	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g04880	Complex: B. thermoamyloliquefaciens alpha-glucosidase II is a homohexamer; Function: B. thermoamyloliquefaciens alpha-glucosidase II is involved in polysaccharide meatabolism.; Remark: a splice site upstream of the start codon was detected.; Similarity: B. thermoamyloliquefaciens alpha-glucosidase II belongs to the glycosyl hydrolase family 31.; Title: strong similarity to alpha-glucosidase II -Bacillus thermoamyloliquefaciens; See PMID 10945254
An01g04890	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g04900	Title: strong similarity to hypothetical protein CAC18296.1 - Neurospora crassa
An01g04910	Title: similarity to hypothetical protein EAK99938.1 - Candida albicans
An01g04920	Complex: S. cerevisiae L29 is part of the 60S subunit of the ribosome.; Function: S. cerevisiae ribosomal protein L29 is involved in the biosynthesis of proteins.; Remark: an alternative name for S. cerevisiae L29 is YL34, or RPL29.; Remark: the original reference for the isolation of S. cerevisiae L29 is Otaka, E.; Higo, K. I.; Itoh, T; Mol. Gen. Genet. 195: 544-546 (1984) which is not available via PubMed.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L29 - Saccharomyces cerevisiae; cytoplasm; See PMID 9008165
An01g04930	Catalytic activity: S. cerevisiae ATP Synthase delta chain produces ATP from ADP in the presence of a proton gradient.; Complex: S. cerevisiae ATP Synthase delta chain is part of the catlytic heteromeric complex ATP-synthase.; Function: S. cerevisiae ATP Synthase delta chain is involved in ATP synthesis.; Remark: the systematic name for ATP16 of S. cerevisiae is YDL004W.; Title: strong similarity to ATP synthase delta chain Atp16 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8026496
An01g04950	Similarity: similarity is from the N-terminal region of the predicted A. niger protein to A. thaliana At2g30890, which is 500aa shorter.; Title: weak similarity to hypothetical protein At2g30890 - Arabidopsis thaliana
An01g04970	Function: human CTNS is a lysosomal cystine transporter.; Function: mutations in human CTNS cause nephropathic cystinosis, an autosomal recessive disorder resulting from defective lysosomal transport of cystine.; Localization: human cystinosin-green fluorescent protein colocalizes with lysosomal-associated membrane protein 2 (LAMP-2) to lysosomes.; Title: strong similarity to lysosomal cystine transporter cystinosin CTNS - Homo sapiens; lysosome; See PMID 9537412; See PMID 10673275; See PMID 11150305
An01g04980	Function: Fusarium sp. Tri6 is involved in the regulation of enzymes, of the trichothecene toxin biosynthesis pathway.; Remark: the predicted A. niger protein contains a zinc-finger-domain in the C-terminus.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: the predicted A. niger protein shows strong similarity to Tri6 transcription activators of several Fusarium species (F. graminearum, F. cerealis, F. sporotrichioides).; Title: similarity to transcription activator Tri6 -Fusarium cerealis; nucleus; See PMID 10635566
An01g04990	Similarity: the predicted A. niger protein shows local similarity to the integrase gene in Pseudomonas putida (aa 169-317)
An01g05000	Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and the polyguluronate lyase gene of Corynebacterium sp. (aa 7-67).; Title: weak similarity to polyguluronate lyase alyPG - Corynebacterium sp.; See PMID 9491925
An01g05010	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g05020	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g05030	Title: strong similarity to oxidoreductase OXRD-8 from patent WO200071679-A2 - Homo sapiens
An01g05040	Complex: dUTP pyrophosphatases are homotrimeric enzymes.; Function: dUTP pyrophosphatases hydrolyze dUTP to dUMP and pyrophosphate, preventing the incorporation of uracil into DNA during replication, and are involved in DNA replication and DNA repair.; Title: strong similarity to dUTP pyrophosphatase DUT1 - Candida albicans; See PMID 7874734; See PMID 8223452
An01g05050	Catalytic activity: pyridoxal kinases convert ATP + pyridoxal to ADP + pyridoxal-5-phosphat.; Function: human PKH is required for the synthesis of pyridoxal-5-phosphate (PLP)1, an essential cofactor for numerous enzymic reactions of intermediary metabolism, from vitaminB6.; Remark: an alternative name for human PKH is PNK.; Title: strong similarity to pyridoxal kinase PKH -Homo sapiens; See PMID 9099727
An01g05060	Title: strong similarity to hypothetical protein EAA66142.1 - Aspergillus nidulans
An01g05070	Title: strong similarity to hypothetical protein SPBC776.06c - Schizosaccharomyces pombe
An01g05080	Similarity: similarity is from the C-terminal half of the predicted A. niger protein to myosin regulator light chain from P. yessoensis, which is 100 aa shorter.; Title: similarity to myosin regulatory light chain -Patinopecten yessoensis; cytoskeleton; See PMID 6706905
An01g05090	Complex: S. pombe cdc16 forms a heterodimer with byr4, which then binds spglp.; Function: S. pombe cdc16 is required for p34cdc2 kinase activity and septum formation.; Function: S. pombe cdc16 negatively regulates septation via Spglp GTPase and its effector cdc7 kinase.; Function: S. pombe cdc16 together with byr4 forms a two-component GTPase-activating protein (GAP) regulating Spglp GTPase.; Localization: using indirect immunofluorescence byr4 localises to the spindle pole bodies except during mitosis.; Similarity: S. pombe cdc16 belongs to the superfamily of cell cycle arrest proteins BUB2.; Title: strong similarity to cell division control protein cdc16p - Schizosaccharomyces pombe; centrosome; See PMID 9742395; See PMID 11271422; See PMID 8334988
An01g05100	Function: N. sylvestris cp29B exists as complex with ribosome-free mRNAs and possibly acts as stabilizing factor.; Localization: N. sylvestris ribonucleoprotein B 29K has been identified from a tobacco chloroplast lysate.; Remark: N. sylvestris ribonucleoprotein B 29K is nuclear encoded.; Similarity: the predicted ORF contains the RNA recognition motiv PF00076 (aa 273-314).; Title: weak similarity to ribonucleoprotein B cp29B - Nicotiana sylvestris; See PMID 11038367; See PMID 1721701
An01g05120	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An01g05150	Function: S. cerevisiae SOL1 suppresses mutations in LOS1, which is a regulator of gene products involved in tRNA expression/function as well as pre-tRNA splicing.; Function: yeast Sol proteins affect tRNA expression/ function at steps other than transcription or splicing.; Induction: LOS1 appears to positively regulate SOL1.; Similarity: similarities from yeast Sol proteins to G6PDs are restricted to areas separate from the catalytic domain.; Similarity: yeast Sol proteins have extensive similarity to an unusual group of glucose-6-phosphate dehydrogenases.; Title: strong similarity to Sol1 - Saccharomyces cerevisiae; See PMID 8725220
An01g05160	Similarity: the predicted A. niger protein contains several WSC domains which are putative carbohydrate binding domains.; Similarity: the predicted A. niger protein shows likely unspecific similarity to serine, proline and threonine rich proteins.; Title: weak similarity to chitinase chiA -Aspergillus nidulans; See PMID 9501518
An01g05180	Title: strong similarity to hypothetical guanine nucleotide binding protein beta subunit-like protein -Schizosaccharomyces pombe
An01g05190	Title: strong similarity to hypothetical protein SPBC15D4.16 - Schizosaccharomyces pombe
An01g05200	Function: DPM2 of M. musculus essential for the ER localization and stable expression of DPM1.; Function: DPM2 of M. musculus regulates the biosynthesis of dolichol phosphate-mannose.; Localization: DPM2 of M. musculus is an integral membrane protein in the endoplasmic reticulum.; Remark: DPM2 of M. musculus interacts with DPM1.; Similarity: DPM2 of M. musculus belongs to the DPM2 family.; Title: strong similarity to DPM2 - Mus musculus; endoplasmatic reticulum; See PMID 9724629
An01g05210	Remark: blastp matches are unspecific.
An01g05220	Remark: blastp matches are unspecific
An01g05230	Remark: the ORF shows also strong similarity to EST an_2899 from Aspergillus niger.; Title: weak similarity to hypothetical protein CAE76314.1 - Neurospora crassa
An01g05260	Function: S. cerevisiae Mph1p is required for the protection of the genome from spontaneous and chemically induced damage.; Function: S. cerevisiae mph1 mutants display a spontaneous mutator phenotyp.; Function: in S. cerevisiae the mph1 mutator phenotype was dependent on REV3 and RAD6.; Function: it has been proposed that Mph1 affects the rate of DNA lesion formation, e. g., by modulating the susceptibility of DNA to chemical attack through compaction of Chromatin, changes of DNA twist or changes of secondary structure.; Remark: the systematic name for S. cerevisiae MPH1 is YIR002c.; Similarity: S. cerevisiae Mph1p shows strong similarity to ATP-dependent RNA helicases.; Title: strong similarity to DEAH protein Mph1 -Saccharomyces cerevisiae; nucleus; See PMID 10880470
An01g05270	Title: weak similarity to extracellular proteinase prtY - Lactobacillus helveticus; See PMID 10923793
An01g05280	Title: strong similarity to hypothetical protein encoded by An11g07100 - Aspergillus niger
An01g05290	Remark: a possible sequencing error occured and was corrected with a frame shift of 1 bp.; Remark: the extracted protein is N-terminal longer than most of the matching proteins.; Title: strong similarity to actin-capping protein beta chain - Gallus gallus [putative frameshift]; cytoskeleton; putative frameshift; See PMID 2745461
An01g05300	Function: S. pombe TAF72 is a subunit of the RNA-pol II transcription factor TFIID and is required for activated but not basal transcription.; Remark: a putative sequencing error was corrected by introducing a frameshift of 1 bp.; Remark: a series of deletion mutants of S. pombe TAF72 revealed that the most evolutionarily conserved regions, including the WD40 repeats, are in fact indispensable for viability.; Title: strong similarity to subunit of transcription initiation factor TFIID taf72p - Schizosaccharomyces pombe [putative frameshift]; nucleus; putative frameshift; See PMID 10721692; See PMID 9224658
An01g05310	Function: overexpression of S. cerevisiae PPE1 yields phenotypes similar to those observed after inactivation of the regulatory PP2A subunits B and B'.; Function: phosphoprotein phosphatase 2A (PP2A) catalytic subunit contains a methyl ester on its C-terminus which in S. cerevisiae is removed by the specific carboxyl methylesterase PPE1.; Remark: in the PIR protein database S. cerevisiae PPE1 has erronously been annotated as the S. cerevisiae mitochondrial ribosomal protein YmS2.; Title: strong similarity to protein phosphatase methylesterase Ppe1 - Saccharomyces cerevisiae; See PMID 11060018
An01g05320	Title: strong similarity to hypothetical protein SPAC23C11.06c - Schizosaccharomyces pombe
An01g05330	Function: S. cerevisiae NPL4 is required for nuclear export and import of proteins and RNA.; Localization: S. cerevisiae NPL4 is located at the nuclear periphery and localizes in a pattern similar to nuclear pore complex proteins.; Title: strong similarity to nuclear transport regulator Npl4 - Saccharomyces cerevisiae; nucleus; See PMID 8930904
An01g05340	Catalytic activity: 1,4-benzoquinone reductases convert 1,2,4-trihydroxybenzene + NAD to hydroxybenzoquinone + NADH2.; Complex: P. chrysosporium qr forms a homomdimer.; Induction: expression of P. chrysosporium qr is induced by 2-dimethoxybenzoquinone, vanillic acid, or several other aromatic compounds.; Localization: a S. cerevisiae protein, Pst2p with strong similarity to the predicted A. niger protein has been identified as a protoplast secreted protein.; Remark: the IUPAC proposes EC 1. 6. 5. 7. for 1,4-benzoquinone reductases.; Title: strong similarity to 1,4-benzoquinone reductase qr - Phanerochaete chrysosporium; extracellular/secretion proteins; See PMID 9925562
An01g05350	Complex: S. cerevisiae Yth1p interacts with Fip1p,another component of the PF I.; Complex: S. cerevisiae Yth1p is a subunit of the polyadenylation factor I (PF I), a key component of the RNA 3'-end processing machinery.; Function: S. cerevisiae Yth1p binds RNA polymers with a distinct preference for poly(U).; Function: S. cerevisiae yth1 mutants have normal mRNA cleavage activity, but fail to polyadenylate the upstream cleavage product.; Remark: the systematic name for S. cerevisiae YTH1 is YPR107c.; Similarity: S. cerevisiae Yth1p contains five C3H-zinc-finger repeats and a putative RNA-binding zinc knuckle motif at the carboxyl terminus.; Title: strong similarity to RNA-binding polyadenylation factor I subunit Yth1 - Saccharomyces cerevisiae; nucleus; See PMID 10371034; See PMID 9224719
An01g05360	Catalytic activity: chitinases hydrolyse the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Title: strong similarity to 42 kDa endochitinase Tham-ch - Trichoderma hamatum; See PMID 9742695
An01g05370	Remark: a splice site upstream of the START-codon was detected.; Similarity: the ORF displays strong similarity to the A. niger EST an_2772.; Title: similarity to hypothetical protein encoded by An09g04380 - Aspergillus niger
An01g05390	Title: similarity to hypothetical protein YBR007c -Saccharomyces cerevisiae
An01g05400	Remark: the central region of the predicted A. niger protein shows weak similarity to small molecule binding proteins.; Title: weak similarity to hypothetical protein 6R55.1 - Caenorhabditis elegans
An01g05410	Title: strong similarity to hypothetical protein EAA65709.1 - Aspergillus nidulans
An01g05450	Function: Pho85p interacts with the cyclin Pcl1p/Hcs26p and Pcl2p to regulate cell cycle progression.; Function: Pho85p-Pho80p Cyclin CDK is required for negative regulation of Pho4p transcription factor in response to phosphate.; Function: cyclin-dependent protein kinase Pho85p interacts with the cyclin Pho80p.; Remark: Pho85 was originally discovered as a regulator of phosphate metabolism but roles for Pho85 in glycogen biosynthesis, actin regulation and cell cycle progression have since been discovered.; Remark: YPL031C is the systematic name for PHO85.; Title: strong similarity to cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 10740818; See PMID 8108735
An01g05460	Title: strong similarity to hypothetical protein encoded by An11g00170 - Aspergillus niger
An01g05470	Title: strong similarity to hypothetical protein F14J16.17 - Arabidopsis thaliana
An01g05480	Title: similarity to hypothetical protein encoded by An06g00890 - Aspergillus niger
An01g05500	Title: strong similarity to hypothetical trp asp repeat protein - Schizosaccharomyces pombe
An01g05510	Complex: Arp2/3 complex 34 kD subunit belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc,p20-arc and p16-arc.; Function: Arp2/3 complex 34 kD subunit forms part of a complex implicated in the control of actin polymerization in cells.; Similarity: Arp2/3 complex 34 kD subunit shows strong similarity to other p34-arc subunits.; Title: strong similarity to GABA-A receptor epsilon-like subunit - Homo sapiens; cytoskeleton; See PMID 9230079
An01g05540	Title: similarity to hypothetical protein T27E13.9 -Arabidopsis thaliana
An01g05560	Title: similarity to hypothetical protein SPCC18.12c - Schizosaccharomyces pombe
An01g05570	Title: similarity to hypothetical protein SPBC21D10.07 - Schizosaccharomyces pombe
An01g05580	Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: similarity to hypothetical periodic tryptophan protein Pwp1 - Saccharomyces cerevisiae [truncated ORF]
An01g05590	Title: strong similarity to EST an_3161 -Aspergillus niger
An01g05610	Complex: human RRN3 interacts directly with TAF(I)110 and TAF(I)63 of promoter-selectivity factor SL1.; Function: human RRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.; Function: human RRN3 mediates growth-dependent control of ribosomal RNA synthesis.; Remark: an alternative name for human RRN3 is TIF-IA.; Title: strong similarity to RNA polymerase I transcription factor RRN3 - Homo sapiens; nucleus; See PMID 10758157; See PMID 11250903; See PMID 11265758
An01g05620	Function: Pseudomanas sp. lipP has a 1,3-positional specificity toward triolein and uses p-Nitrophenyl esters of fatty acids with short to medium chains (C4 and C6) as substrate.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382
An01g05630	Remark: the single exon of the predicted A. niger protein shows strong similarity to several aspartate-tRNA ligases, which are general about 400 aa shorter.; Title: strong similarity to cytoplasmic aspartate--tRNA ligase Aps - Saccharomyces cerevisiae; cytoplasm
An01g05640	Remark: the ORF shows local similarity to the hypothetical protein B17C10. 270 of N. crassa: only 41 amino acids are included in the alignment.; Title: similarity to hypothetical protein B17C10.270 - Neurospora crassa
An01g05650	Phenotype: a tubA mutation (tubA4) causes supersensitivity to benomyl during vegetative growth.; Remark: A. nidulans possesses 2 tubulin genes: tubB is required for sexual development and tubA is required during vegetative growth for mitosis and nuclear migration.; Remark: tubA of A. nidulans belongs to the tubulin family.; Remark: tubulin is the major component of microtubules.; Title: strong similarity to tubulin alpha-1 chain tubA - Aspergillus nidulans; See PMID 8336695; See PMID 8601474; See PMID 1672037
An01g05660	Localization: Ede1 of S. cerevisiae is localized in punctate cortical spots that only partially colocalize with actin patches.; Phenotype: deletion of Ede1 of S. cerevisiae impairs the diploid budding pattern, but has only a small impact on actin cytoskeleton organization.; Phenotype: deletion of Ede1 of S. cerevisiae leads to a defective fluid-phase endocytosis and to defective internalization of the pheromone (alpha)-factor and uracil permease.; Remark: Ede1 of S. cerevisiae belongs to the VDP/uso1/YBL047c family.; Remark: Ede1 of S. cerevisiae is also called YBL047c and YBL0520.; Remark: the ORF overlaps C-terminally with the A. niger EST an_3336 in EMBLEST:BE759046.; Similarity: the ORF shows additionally similarity to other proteins containing an EH domain, like epithermal growth factor receptor substrates.; Similarity: the ORF shows local strong similarity to Ede1 of S. cerevisiae: the proteins overlap in the N-terminal half.; Title: strong similarity to endocytosis protein Ede1 - Saccharomyces cerevisiae; See PMID 10954428
An01g05670	Function: Pma1 of S. cerevisiae is a hydrogen ion pump, the proton gradient generated by the enzyme drives the active transport of nutrients by H+-symport.; Induction: expression of Pma1 of S. cerevisiae is strongly stimulated during growth adaption under high copper stress, presumably triggered by the resulting intracellular acidification. This physiological response may allow the cells to cope with copper-induced lipid peroxidation and consequent decrease in plasma membrane lipid ordering and increase in the non-specific permeability to protons.; Phenotype: null mutation of Pma1 of S. cerevisiae is lethal in haploid cells.; Remark: Pma1 of S. cerevisiae is also called G3737 andYGL008c.; Title: strong similarity to H+-transporting ATPase Pma1 - Saccharomyces cerevisiae; plasma membrane; See PMID 11284007; See PMID 11481477; See PMID 3005867
An01g05680	Similarity: the ORF is 250 amino acids shorter than B1D1. 200 of N. crassa.; Similarity: the ORF shows local strong similarity to B1D1. 200 of N. crassa: only 71 N-terminal amino acids are included in the alignment.; Title: similarity to hypothetical myocyte-specific enhancer factor 2d related protein B1D1.200 - Neurospora crassa
An01g05690	Complex: orc5 is one of the six subunits of ORC.; Function: ORC is important for chromosomal replication and mating type transcriptional silencing.; Function: orc5 of S. pombe is a part of the origin recognition complex (ORC) that binds to DNA origins.; Remark: orc5 of S. pombe belongs to the orc5 family.; Similarity: the ORF is 113 amino acids longer than orc5 of S. pombe, however, due to gap introduction, the complete orc5 and ORF sequences are aligned.; Title: strong similarity to origin recognition complex subunit 5 orc5p - Schizosaccharomyces pombe; See PMID 10535928
An01g05700	Function: pumilio of X. laevis binds cyclin B1 mRNA and interacts with Xcat-2 (a Nanos homolog) and CPEB (a key regulator of translational repression and activation of mRNAs stored in oocytes).; Remark: pumilio is a translational repressor by binding to the 3' UTR of mRNA and thereby involved in developmental regulation.; Remark: the ORF is 189 amino acids longer than pumilio of X. laevis, in the alignment between the two proteins about 100 N- and C-terminal amino acids of the ORF are lacking.; Title: strong similarity to cyclin B1 mRNA-binding protein pumilio - Xenopus laevis; See PMID 11283000; See PMID 11441171
An01g05710	Title: similarity to hypothetical protein CAD21190.1 - Neurospora crassa
An01g05720	Remark: the ORF's intron/exon structure is unusual for A. niger and the ORF is short in length (123 amino acids).; Title: questionable ORF
An01g05730	Function: OsMST3 of O. sativa has transport activity for some monosaccharides in an energy-dependent H+ co-transport manner.; Function: OsMST3 of O. sativa is involved in the accumulation of monosaccharides required for cell wall synthesis at the stage of cell thickening.; Remark: 100 N-terminal amino acids of the ORF are lacking in the alignment with OsMST3 of O. sativa.; Remark: a putative frameshift results in an premature STOP codon.; Title: strong similarity to monosaccharide transporter 3 OsMST3 - Oryza sativa [putative frameshift]; putative frameshift; See PMID 11038054
An01g05740	Catalytic activity: RNA polymerase III catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time.; Complex: RP128 of D. melanogaster is the second largest chain of RNA polymerase III.; Function: DNA-dependent RNA polymerase III transcribes DNA encoding tRNA and 5S RNA genes into RNA.; Remark: RP128 of D. melanogaster belongs to the RNA polymerase beta-chain family.; Title: strong similarity to 132 kD subunit of DNA-directed RNA polymerase III RP128 - Drosophila melanogaster; nucleus; See PMID 1910149
An01g05750	Title: similarity to hypothetical indole-diterpene gene cluster protein paxU - Penicillium paxilli; See PMID 11169115
An01g05760	Function: UFD1 of S. cerevisiae functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway.; Function: furthermore UFD1 of S. cerevisiae interacts with the poly(A) polymerase and thereby affects polyadenylation.; Remark: UFD1 of S. cerevisiae is also called G4318 and YGR048w.; Remark: ubiquitination marks a protein for degradation.; Title: strong similarity to ubiquitin fusion degradation protein Ufd1 - Saccharomyces cerevisiae; See PMID 9236779; See PMID 7615550
An01g05770	Function: CD2BP of H. sapiens binds a cytoplamic region of CD2.; Remark: CD2 is a T cell surface antigen, recognizing LFA-3 on antigen-presenting cells.; Remark: overexpression of CD2BP of H. sapiens enhances IL-2 production by crosslinking of CD2 but not of the T cell receptor.; Similarity: the ORF is 110 amino acids longer than CD2BP of H. sapiens, the alignment between the two proteins lacks about 100 N-terminal amino acids of the ORF.; Title: similarity to CD2 binding protein CD2BP -Homo sapiens; See PMID 9843987; See PMID 10404223
An01g05780	Function: Tih2 of S. cerevisiae is required for vegetative cell growth and localizes in the nucleus.; Function: furthermore, Tih2 of S. cerevisiae is required for transcription of G(1) cyclin and of several ribosomal protein genes.; Remark: Tih2 of S. cerevisiae is also called YPL235w or P1060.; Remark: Tih2 of S. cerevisiae may be involved in the regulation of RNA polymerase II-directed transcription.; Remark: Tih2 of S. cerevisiae tightly interacts with Tih1, which has been shown to interact with the TATA-binding protein and the RNA polymerase II holoenzyme complex.; Title: strong similarity to RuvB-like protein Tih2 -Saccharomyces cerevisiae; See PMID 10787406
An01g05790	Function: uso1 of S. cerevisiae is required for intracellular protein transport in S. cerevisiae, probably the protein transport from the ER to the later secretory compartments.; Phenotype: uso1 mutant S. cerevisiae strains were blocked in the protein secretion pathway and are not able to induce sexual aggregation.; Similarity: the ORF is 835 amino acids shorter at the C-terminus than uso1 of S. cerevisiae; the similarity is restricted to the C-terminal part, which is probably dispensable for the protein function.; Similarity: the ORF shows similarity to myosin heavy chains from some species.; Title: similarity to transport protein Uso1 -Saccharomyces cerevisiae; See PMID 2373371; See PMID 2715179
An01g05800	Function: estf1 of P. fluorescens shows highest activity towards lactones and significantly lower activity towards aliphatic esters with the exception of ethyl caprylate.; Localization: estf1 of P. fluorescens is membrane bound or membrane associated.; Similarity: the ORF shows local similarity to estf1 of P. fluorescens: only the N-terminal half is included in the alignment.; Similarity: the ORF shows strong similarity to the hypothetical abhydrolase (SPAC22H12. 03) of S. cerevisiae.; Title: similarity to lactone-specific esterase estf1 - Pseudomonas fluorescens; See PMID 9925571
An01g05810	Title: strong similarity to hypothetical protein CAE85516.1 - Neurospora crassa
An01g05820	Pathway: hpcE of E. coli is part of the homoprotocatechuate (HPC; 3,4-dihydroxyphenylacetate) degradative operon.; Remark: homoprotocatechuate is catabolized to Krebs cycle intermediates and part of the tyrosine metabolism.; Remark: hpcE of E. coli encodes two functionalities: the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5. 3. 3. -) and the 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4. 1. 1. -).; Similarity: the C-terminal part of the ORF (35 amino acids) and 154 N-terminal amino acids of hpcE are not included in the alignment between the two proteins.; Similarity: the ORF is 110 amino acids shorter than hpcE of E. coli.; Title: strong similarity to homoprotocatechuate operon enzyme hpcE - Escherichia coli; See PMID 8223600; See PMID 8384293
An01g05830	Function: the drug transporter CYHR of C. maltosa mediates resistance to cycloheximide.; Similarity: only the N-terminal parts of the two proteins (ORF and CYHR of C. maltosa) are aligned.; Similarity: the ORF shows similarity to several MDR proteins from different species.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; See PMID 1628836
An01g05840	Remark: C-terminally truncated ORF due to contig border.; Similarity: the central part of the predicted ORF shows some weak and partial similarity to a novel human DNA binding protein called GLUT4 enhancer factor.
An01g05850	Remark: in A. nidulans, the gene is adjacent to sncB, a suppressor of the nudC mutation.; Title: strong similarity to hypothetical protein AAB38299.1 - Aspergillus nidulans; See PMID 8647384
An01g05860	Similarity: other BLASTP matches are mainly due to poly-Ser stretches.; Title: weak similarity to hypothetical secreted antigen SagBb - Enterococcus hirae
An01g05880	Similarity: the predicted ORF shows a partial and weak similarity to the C-terminal region of the B. taurus neurofilament-M subunit.; Title: similarity to hypothetical protein encoded by An11g00170 - Aspergillus niger
An01g05890	Similarity: Dof2 of Z. mais was identified due to the presence of a putative DNA binding motif, called Dof domain; Dof2 has no known function.; Similarity: the predicted ORF is very rich in low complexity regions, and the BLASTP hits are mainly due to repetitive elements.; Title: weak similarity to hypothetical DNA-binding protein Dof2 - Zea mays; See PMID 7567449
An01g05900	Function: CYP58 of F. sporotrichioides is encoded by the Tri4 gene and is involved in trichothecene biosynthesis.; Function: due to the extreme variety of substrates and reactions catalyzed, it is difficult to assess substrate specificity by homology comparison.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the protein shows strong similarity to the large superfamily of P450 cytochromes, which are heme-thiolate proteins acting as terminal oxidase in multicomponent electron transfer chains.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An01g05920	Title: strong similarity to hypothetical methyltransferase AAO34671.1 - Gibberella zeae
An01g05960	Function: CV-N of N. ellipsosporum binds with extremely high affinity to highly conserved binding site(s) on the viral envelope glycoprotein gp120, preventing virus-to-cell fusion, viral entry and infection of cells.; Function: cyanovirin-N of N. ellipsosporum is a potent HIV (human immunodeficiency virus)-inactivating protein.; Remark: cyanovirin-N of N. ellipsosporum has been patented under Patent N. WO9634107-A2.; Similarity: the predicted ORF is identical to several A. niger ESTs (e. g. EMBL EST Acc. BE760612,BE758894).; Title: similarity to cyanovirin-N CV-N - Nostoc ellipsosporum; See PMID 9299483; See PMID 10794101
An01g05970	Title: similarity to hypothetical protein CAD70385.1 - Neurospora crassa
An01g05990	Function: abp2 of S. pombe binds the ARS (autonomously replicating sequence) element ars3002 on chromosome III.; Localization: abp2 of S. pombe is likely located within the nucleus.; Phenotype: disruption of the abp2 gene in S. pombe showed that the gene is not essential for cell viability,however the null mutant was hypersensitive to DNA damage,suggesting that abp2 may play a role in regulating the cell cycle response to stress signals.; Remark: N-terminus might be about 100 amino acids shorter due to repetitive elements and weaker homology.; Similarity: abp2 of S. pombe contains a region similar to a proline-rich motif (GRP) present in several proteins that bind A+T-rich DNA sequences, and experimentally proven to be important for the DNA binding activity.; Title: similarity to ARS binding protein 2 abp2p -Schizosaccharomyces pombe; See PMID 9488484
An01g06000	Function: SigA of C. glutamicum encodes one principal sigma factor of the unique bacterial RNA polymerase.; Similarity: BLASTP detects comparable similarities with proteins having different functions and cellular localizations.; Similarity: domain structures functionally characterizing the various similar proteins are not conserved in the predicted ORF.; Similarity: strong similarity to hypothetical protein B7J19. 40 of Neurospora crassa.; Title: similarity to sigma factor SigA -Corynebacterium glutamicum; See PMID 8550480
An01g06010	Title: weak similarity to chromosomal protein D1 -Drosophila melanogaster; See PMID 2542275
An01g06020	Similarity: BLASTP detects several other unrelated similar proteins due to a polyglutamine stretch in the C-terminus.; Title: similarity to hypothetical protein B7J19.160 - Neurospora crassa
An01g06030	Catalytic activity: D-sorbose, D-agatose and 5-dehydro-D-fructose also act as acceptors in the previous reaction.; Catalytic activity: khk of H. sapiens catalyzes the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.; Pathway: khk of H. sapiens is involved in the fructose and mannose primary metabolism.; Phenotype: defects in khk in H. sapiens are the cause of fructosuria, a benign disease of intermediary metabolism.; Remark: in H. sapiens two forms (a and c) of khk are produced by alternative splicing.; Remark: khk of H. sapiens requires potassium.; Repression: khk of H. sapiens is inhibited by ADP.; Similarity: the predicted ORF shows weaker similarities with some ribokinases, suggesting that the substrate specificity might also be different.; Title: strong similarity to ketohexokinase khk -Homo sapiens; See PMID 7833921; See PMID 9799106; See PMID 2996495
An01g06040	Localization: the membrane localization suggested by the title is very questionable.; Title: strong similarity to hypothetical membrane protein YOL077c - Saccharomyces cerevisiae
An01g06050	Similarity: the predicted ORF shows a weak and partial similarity to an ABC transporter protein of S. aureus, patentnumber WO9950418-A1.
An01g06060	Function: rab11 of R. norvegicus influences endosome to TGN vesicular trafficking.; Localization: small GTP binding proteins of the rab family are associated with the cytoplasmic surface of compartments of the central vacuolar system.; Similarity: rab11 of R. norvegicus belongs to the ras transforming protein superfamily, and more precisely to the rab family of small GTP binding proteins.; Similarity: the gene model is strongly supported by local identity to several EST clones, in particular A. niger EMBLEST Acc. BE758911 and BE759254.; Similarity: the predicted ORF shows strong similarities with other members of the rab family identified in plants and fungi.; Title: strong similarity to GTP-binding protein rab11 - Rattus norvegicus; intracellular transport vesicles; See PMID 10332741; See PMID 11121436; See PMID 1711847
An01g06070	Remark: chp1 of S. pombe is also called SPAC18G6. 02c.; Similarity: chjp1 of S. pombe contains a chromo (chromatin organisation modifier) domain and is required for centromere function.; Similarity: part of the predicted ORF is identical to A. niger EST EMBLEST Acc. BE758993.; Similarity: the similarity with CHP1 of S. pombe is limited to the N-terminal tenth of the predicted ORF.; Title: weak similarity to chromo domain protein 1 chp1p - Schizosaccharomyces pombe; See PMID 9722643
An01g06080	Catalytic activity: ClpX of M. musculus has an ATPase activity.; Complex: ClpX of M. musculus is the regulatory subunit of a two component chaperone/protease complex; in this complex ClpX act as a chaperone molecule, while the protease subunit is called ClpP.; Function: the proposed function of the ClpX/ClpP complex in eukaryotic mitochondria is to exhert functions similar to the proteasome in this subcellular compartment.; Similarity: ClpX of M. musculus is a member of the Hsp100/Clp chaperone family, whose members participate in a broad range of biological processes in both prokaryotes and eukaryotes.; Similarity: in bacteria the ClpX/ClpP complex reveal a structural organization and a function homologous to that of the eukaryotic 26S proteasome.; Title: strong similarity to energy-dependent regulator of proteolysis ClpX - Mus musculus; localisation:mitochondrion; See PMID 10347188
An01g06090	Title: strong similarity to EST an_1250 -Aspergillus niger
An01g06100	Similarity: very weak similarity to a small fragment of spen, a D. melanogaster gene involved in development.
An01g06110	Catalytic activity: GPD1 of S. cerevisiae catalyzes the reaction: sn-glycerol 3-phosphate + NAD(+) <=> glycerone phosphate + NADH.; Function: as osmotic balance regulates cell fusion during mating in S. cerevisiae, a secondary effect of GDP1 mutations is an impairment of cell fusion.; Function: whereas GDP1 is mainly involved in osmoregulation, GDP2 is required to regulate metabolism under anoxic conditions, when glycerol formation is strictly required as a redox sink for excess cytosolic NADH.; Induction: expression of GPD1 of S. cerevisiae is induced by osmotic stress.; Remark: GPD1 of S. cerevisiae is produced with an N-terminal extension that is removed from the functional enzyme; this extension does not target GDP1 to any organelle.; Similarity: S. cerevisiae has a second glycerol-3-phosphate dehydrogenase called GPD2, which is 69% identical to GPD1.; Similarity: the predicted ORF belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.; Title: strong similarity to glycerol-3-phosphate dehydrogenase (NAD+) precursor Gpd1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7934860; See PMID 8196651; See PMID 9171333; See PMID 9281576; See PMID 7476212
An01g06120	Catalytic activity: endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked-alpha-D-glucose residues.; Catalytic activity: transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor, which may be glucose or a 1,4-alpha-D-glucan.; Function: the glycogen debranching enzyme in mammals and yeast is involved both in the catabolism and in the biosynthesis of glycogen; its transferase activity is important for branching rearrangement.; Phenotype: in H. sapiens mutations of the glycogen debranching enzyme gene AGL cause a pathology known as glycogenosis type III.; Remark: GDB1 of S. cerevisiae is also known as YPR184w.; Remark: in H. sapiens the structure of the transcript of the AGL gene shows high degree of polymorphism, due to alternative transcription starts and alternative splicing, giving rise to different tissue-specific isoforms.; Similarity: 4-alpha-glucanotransferase / amylo-1,6-glucosidase is also called glycogen debranching enzyme, a bifunctional protein conserved from yeast to humans.; Title: strong similarity to 4-alpha-glucanotransferase / amylo-1,6-glucosidase Gdb1 -Saccharomyces cerevisiae; See PMID 8954797; See PMID 11094287
An01g06130	Title: strong similarity to hypothetical membrane protein YLR241w - Saccharomyces cerevisiae
An01g06140	Complex: subunit II is one of the three major components of the complex of the respiratory chain that catalyzes the reduction of oxygen to water on the inner mitochondrial membrane.; Remark: due to their strong evolutionary conservation, cytochromes are often used for molecular phylogenetic comparison.; Remark: the COII gene of K. blattae is encoded by the mitochondrial genome.; Similarity: the predicted ORF shows weak similarity to a region of many cytochrome c oxidase subunits II of different fungal species.; Title: weak similarity to cytochrome c oxidase subunit II COII - Kluyveromyces blattae; See PMID 10826829
An01g06150	Catalytic activity: DAHP synthase catalyzes the condensation of erythrose-4-phosphate (E4P) and phosphoenolpyruvate (PEP) to yield DAHP (3-deoxy-D-arabino-heptulosonate-7-phosphate).; Cofactor: both aroG and aroF of A. nidulans are inhibited by the chelating agent EDTA, which indicates a metal ion as cofactor.; Function: DAHP synthases catalyze the first committed step of the shikimate pathway, which ultimately leads to the biosynthesis of folates, ubiquinone, aromatic amino acids, and derivatives.; Repression: aroG and aroF of A. nidulans are differentially regulated by phenylalanine and tyrosine,respectively.; Repression: phenylalanine is a competitive inhibitor of the isoenzyme aroG in its reaction with E4P (erythrose-4-phosphate).; Similarity: in A. nidulans two DAHP synthase isoenzymes exist, and are called aroG and aroF.; Title: strong similarity to phe-inhibited DAHP synthase aroG - Aspergillus nidulans; See PMID 11285739
An01g06160	Title: weak similarity to hypothetical ABC transporter - Schizosaccharomyces pombe
An01g06170	Title: strong similarity to EST an_1229 -Aspergillus niger
An01g06180	Catalytic activity: cytochrome c1 accepts electrons from the Rieske Fe-S protein and tranfers them to cytochrome c.; Catalytic activity: the complete cytochrome b-c1 enzyme complex catalyzes electron transfer from ubiquinol to the soluble cytochrome c; the transfer is coupled to translocation of two protons across the inner mithochondrial membrane per quinol oxidized.; Complex: the main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske Fe-S protein; in all organisms studied, the complex consists of 9-11 different polypeptides, and has an Mr of 240 kD.; Function: CYT1 of N. crassa is one heme-containing component of the cytochrome b-c1 complex, also called ubiquinol-cytochrome c oxidoreductase; it is a constituent of the mitochondrial respiratory chain.; Localization: cytochrome c1 is anchored to the inner mitochondrial membrane with its N-terminus protruding into the mitochondrial intermembrane space.; Remark: cytochrome b-c1 complex is highly conserved among living organisms; the crystal structure of the complete complex of mammals and chicken was determined.; Remark: the cytochrome c1 is synthesized as precursor, containing a N-terminal presequence removed by a peptidase.; Similarity: the predicted ORF is 14 amio acids shorter at the C-terminus than the N. crassa protein.; Title: strong similarity to cytochrome c1 of ubiquinol--cytochrome c reductase CYT-1 - Neurospora crassa; localisation:mitochondrion; See PMID 9204897; See PMID 9565029; See PMID 11192733; See PMID 11245784; See PMID 3030747
An01g06190	Function: it is proposed that, in general, the AAA domains act as ATP-dependent protein clamps.; Function: the PCH2 gene of S. cerevisiae is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective.; Localization: most of the PCH2 protein localizes to the nucleolus; nucleolar localization of PCH2 is regulated by different proteins involved in meiotic checkpoint control.; Remark: PCH2 of S. cerevisiae is also known as YBR186w.; Similarity: strong similarity to HPV16 E1 binding protein of H. sapiens, a protein with unknown molecular function, but interacting with human papillomavirus E1 ATP-dependent DNA helicase.; Similarity: the predicted ORF contains a conserved region of about 220 amino acids that contains an ATP-binding site, and is called AAA, for 'A'TPases 'A'ssociated with diverse cellular 'A'ctivities.; Title: strong similarity to pachytene checkpoint protein Pch2 - Saccharomyces cerevisiae; nucleus; See PMID 9223484; See PMID 10319812; See PMID 11029058
An01g06200	Title: questionable ORF
An01g06210	Function: Rcy1 of S. cerevisiae is required for the recycling of internalized material to the plasma membrane anfter endocytosis.; Phenotype: S. cerevisiae cells with a Rcy1 null mutation are defective in endocytosis at an early postinternalization step, and are defective in recycling.; Remark: Rcy1 of S. cerevisiae is also known as YJL204c.; Similarity: Rcy1 of S. cerevisiae contains, near its N-terminus, an F-box domain, a motif which links the target protein with a ubiquitin-conjugating enzyme; the F-box is just marginally conserved in the predicted ORF.; Similarity: the predicted ORF shows strong similarity with the SLS2 gene of Y. lipolytica, whose molecular function is unknown, but can be important in secretory pathways.; Title: strong similarity to F-box protein Rcy1 -Saccharomyces cerevisiae; See PMID 10394896; See PMID 10769031
An01g06220	Function: while C. albicans rbt4 strains show no phenotypes on several laboratory media, they had significantly reduced virulence.; Regulation: expression of C. albicans Rbt4 is induced in wild-type cells during the switch from the yeast form to filamentous growth, under control of TUP1.; Remark: ORF 5'truncated due to end of contig.; Title: strong similarity to secreted RBT4 - Candida albicans [truncated ORF]; extracellular/secretion proteins
An01g06230	Complex: eIF3 consists of at least 10 subunits: p170, p116 (eIF3 beta), p110, p66, p48, p47, p44, p40, p36, and p35.; Function: eIF3 stimulates the binding of Met-tRNAf (as a Met-tRNAf. eIF2. GTP ternary complex) to 40 S ribosomal subunits.; Title: strong similarity to translation initiation factor 3 subunit eIF3 beta - Homo sapiens; cytoplasm; See PMID 8995410; See PMID 9388245
An01g06240	Function: SWI/SNF is a chromatin-remodeling complex.; Function: yeast SWI/SNF complex is required for transcriptional activation by the glucocorticoid receptor.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3193.; Similarity: similarity is from the topoisomerase I associated Zn-finger domain containing C-terminal region of the predicted A. niger protein to the central region of M. musculus BAF60a, which is 200 aa longer.; Similarity: the predicted A. niger protein contains a topoisomerase I associated Zn-finger domain.; Title: similarity to SWI/SNF complex subunit BAF60a - Mus musculus; nucleus; See PMID 11420722; See PMID 8804307
An01g06250	Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain. -; Title: strong similarity to hypothetical zinc-finger protein SPCC1223.01 - Schizosaccharomyces pombe
An01g06260	Complex: human MSH4 interacts specifically with MSH5 to form a heterodimer and MLH1.; Function: human MSH4 is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I.; Similarity: human MSH4 belongs to the eucaryotic E. coli MutHLS homologes, where MutS homologs in eucaryotes have evolved to play crucial roles in DNA mismatch repair and/or meiotic recombination.; Title: strong similarity to meiotic recombination protein MSH4 - Homo sapiens; nucleus; See PMID 10928988; See PMID 9299235; See PMID 10029069
An01g06270	Complex: D. melanogaster Nle binds to the cytoplasmic domain of Notch.; Function: X. laevis nle is a modulator of Notch signaling, with mutatios in D. melanogaster nle but also overexpression of D. melanogaster or X. laevis Nle enhancing Notch activity.; Title: strong similarity to modulator of Notch activity notchless nle - Xenopus laevis; See PMID 9857191
An01g06280	Remark: informations have only been published in Hemmann S. Thesis (1998), Institute of Biochemistry,University of Zurich Switzerland.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with PATENTDNA:AAF11390 A. niger EST 3913.; Title: strong similarity to IgE-binding protein -Aspergillus fumigatus; See PMID 9723708
An01g06290	Title: strong similarity to hypothetical protein related to VeA - Neurospora crassa
An01g06310	Catalytic activity: A. oryzae gtaA catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006
An01g06320	Title: weak similarity to hypothetical protein SCP1.259 - Streptomyces coelicolor
An01g06330	Function: S. cerevisiae UPC2 is a heme-inhibited activator involved in sterol uptake and regulation of cell wall mannoproteins.; Remark: alternative names for S. cerevisiae UPC2 are MOX4 and YDR213w.; Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1035.; Remark: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: S. cerevisiae UPC2 is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type.; Similarity: similarity is between the predicted A. niger protein and the C-terminal region of S. cerevisiae UPC2, which is 600 aa longer.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; nucleus; See PMID 11208779; See PMID 11292809
An01g06340	Title: weak similarity to hypothetical protein G65A3.10 - Neurospora crassa
An01g06350	Function: human GnT-IV is an essential enzyme in the production of tri- and tetra-antennary Asn-linked sugar chains.; Title: weak similarity to UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase GnT-IV - Homo sapiens; See PMID 9565571; See PMID 10570912
An01g06360	Function: A. alternata Akt3-1 is involved in AK-toxin biosynthesis.; Function: P. putida FadB is essential for the beta-oxidation of certain n-phenylalkanoyl-CoA derivatives when they reach a critical size.; Similarity: the predicted A. niger protein contains an enoyl-CoA hydratase motif and shows similarity to several putative enoyl-CoA hydratases and Pseudomonas putida FadB.; Title: strong similarity to AK-toxin production protein Akt3-1 - Alternaria alternata; See PMID 10975654; See PMID 11251808
An01g06370	Similarity: the ORF shows strong similarity to EST EMBLEST:BE758779 an_3023 of Aspergillus niger.; Title: strong similarity to hypothetical protein YKR065c - Saccharomyces cerevisiae
An01g06380	Title: weak similarity to serotonin receptor -Didelphis marsupialis virginiana
An01g06390	Similarity: the N-terminal region of the predicted protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: the ORF shows strong similarity to the A. niger EST EMBLEST:BE760705 an_0337.; Title: strong similarity to hypothetical protein EAA65779.1 - Aspergillus nidulans
An01g06410	Remark: a putative sequencing error results in an premature STOP codon.; Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260w.; Similarity: the ORF shows similarity to some allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 10869563
An01g06420	Title: weak similarity to hypothetical protein CAE81933.1 - Neurospora crassa
An01g06430	Remark: putative prolin rich protein.
An01g06440	Similarity: this gene shows also strong similarity to EST SEQ ID NO:4296 from patent WO200056762-A2 -Aspergillus niger.; Title: similarity to hypothetical protein CAE28089.1/RPA2648 - Rhodopseudomonas palustris
An01g06470	Function: CB-CYP4 of C. briggsae belongs to the peptidyl-prolyl cis-trans isomerase (rotamase)/cyclophilin family, which facilitates the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Similarity: the ORF shows similarity to several peptidyl-prolyl cis-trans isomerases from different species.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase CB-CYP4 - Caenorhabditis elegans
An01g06480	Complex: hetero-oligomeric complex of about 850 to 900 kda that forms two stacked rings, 12 to 16 nm in diameter.; Function: molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin. in yeast may play a role in mitotic spindle formation.; Remark: TCP1 beta supplies an essential function that partially overlaps with that of TCP1 alpha in acting as a molecular chaperone in tubulin and spindle biogenesis.; Similarity: belongs to the molecular chaperone t-complex-type proteins.; Title: strong similarity to TCP1 complex beta chain TCP1 Beta - Saccharomyces cerevisiae; See PMID 7908441; See PMID 7916460
An01g06500	Remark: Phenotypic analysis of dfg mutant strains genetically dissects filamentous growth into the cellular processes of signal transduction, bud site selection, cell morphogenesis and invasive growth. Epistasis tests between dfg mutant alleles and dominant activated alleles of the RAS2 and STE11 genes, RAS2Val19 and STE11-4, respectively,identify putative targets for the filamentation signaling pathway. Several of the genes described here have homologues in filamentous fungi, where they also regulate fungal development.; Remark: alternative name is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077
An01g06510	Remark: the ORF is short in length (116 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An01g06520	Remark: xNopp180 is heavily phosphorylated and it contains multiple consensus sites for phosphorylation by casein kinase II and cdc2 kinase.; Similarity: belongs to the nucleolus-cytoplasm shuttle phosphoprotein.; Title: similarity to nucleolar phosphoprotein xNopp180 - Xenopus laevis; See PMID 7593294
An01g06530	Catalytic activity: L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate + L-Glutamate.; Pathway: valine, leucine and isoleucine degradation; valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: TOXF has a biosynthetic role in HC-toxin synthesis, perhaps to aminate a precursor of Aeo (2-amino-9, 10-epoxi-8-oxodecanoic acid).; Title: strong similarity to branched-chain amino acid aminotransferase TOXF - Cochliobolus carbonum; See PMID 10627051
An01g06540	Title: questionable ORF
An01g06550	Pathway: unfolded protein response pathway (UPR).; Remark: in S. cerevisiae the ER transmembrane receptor, Ire1p, transmits the signal to the nucleus culminating in the transcriptional activation of genes encoding an adaptive response. Yeast Ire1p requires both protein kinase and site-specific endoribonuclease (RNase) activities to signal the UPR.; Similarity: belongs to the serine/threonine protein kinases.; Title: strong similarity to protein kinase Ire1 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; endoplasmatic reticulum; See PMID 11069889; See PMID 1625574; See PMID 8358794
An01g06560	Catalytic activity: N-(L-arginino)succinate = fumarate + L-arginine.; Pathway: urea cycle and metabolism of amino groups; alanine and aspartate metabolism; arginine and proline metabolism.; Remark: argininosuccinate lyase (ASL) catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate, a reaction important for the detoxification of ammonia via the urea cycle and for arginine biosynthesis. ASL belongs to a superfamily of structurally related enzymes, all of which function as tetramers and catalyze similar reactions in which fumarate is one of the products.; Similarity: to other argininosuccinate lyases.; Title: strong similarity to argininosuccinate lyase ASAL - Candida albicans; See PMID 11092456; See PMID 8194754
An01g06570	Title: similarity to hypothetical protein C29F5.1 -Caenorhabditis elegans
An01g06580	Remark: the ORF is short in length (91 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An01g06600	Remark: the ORF is short in length (51 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An01g06610	Title: strong similarity to hypothetical calcium-related spray protein 1A9.60 - Neurospora crassa
An01g06620	Catalytic activity: hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Remark: RhaA and RhaB, optimally active at pH 4. 5 to 5, showed K(m) and V(max) values of 2. 8 mM and 24 U/mg (RhaA) and 0. 30 mM and 14 U/mg (RhaB) when tested for p-nitrophenyl-alpha-L-rhamnopyranoside.; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105
An01g06630	Catalytic activity: hydrolysis of terminal,non-reducing beta-D-mannose residues in beta-D-mannosides.; Pathway: glycoprotein degradation.; Remark: Man2A is an intracellular enzyme comprising a catalytic module in a subfamily of family 2 of the glycosyl hydrolases that at present contains only mammalian beta-mannosidases.; Similarity: belongs to the beta-galactosidase/beta-glucuronidase family.; Title: strong similarity to mannosidase Man2A -Cellulomonas fimi; See PMID 10347049
An01g06640	Catalytic activity: phenol sulfate + h(2)o = phenol + sulfate.; Function: the P. aeruginosa homolog ATSA catalyzes the hydrolysis of Sulfate esters.; Repression: synthesis of P. aeruginosa ATSA is repressed when sulfate, cysteine or thiocyanate is supplied as the sole sulfur source for growth.; Title: strong similarity to arylsulfatase atsA -Pseudomonas aeruginosa
An01g06650	Title: strong similarity to hypothetical protein PA4204 - Pseudomonas aeruginosa
An01g06660	Catalytic activity: NADH + 2 ferricytochrome b5 <=> NAD(+) + 2 ferrocytochrome b5.; Function: the structure of H. sapiens AAF04812. 1 makes it a potential oxygen sensor.; Remark: the H. sapiens homolog AAF04812. 1 represents a natural fusion of cytochrome b5 (b5) and cytochrome b5 reductase (b5R).; Title: similarity to flavohemoprotein b5/b5R AAF04812.1 - Homo sapiens; cytoplasm
An01g06670	Similarity: the ORF overlaps with A. niger EST an_2741.; Similarity: the ORF shows similarity to cyclophilins and other FK506/rapamycin-binding proteins.; Similarity: the predicted ORF is 81 amino acids shorter at the C-terminus than FKBP-21 of N. crassa.; Title: strong similarity to peptidyl-prolyl isomerase FKBP-21 - Neurospora crassa
An01g06690	Function: the S. cerevisiae homolog ZRT2 encodes a low-affinity zinc transporter.; Induction: S. cerevisiae ZRT1 is expressed in response to zinc deficiency.; Similarity: S. cerevisiae Zrt2p belongs to the family of ZIP metal ion transporters.; Title: strong similarity to low affinity zinc transport protein Zrt2 - Saccharomyces cerevisiae; plasma membrane
An01g06710	Title: similarity to hypothetical phosphorylase AAM06921.1 - Methanosarcina acetivorans
An01g06750	Similarity: the S. coelicolor homolog SCD72A. 11 has weakly similar to many acetyltransferases.; Title: similarity to hypothetical acetyltransferase SCD72A.11 - Streptomyces coelicolor
An01g06760	Title: weak similarity to hypothetical protein encoded by An08g03810 - Aspergillus niger
An01g06770	Title: similarity to hypothetical protein encoded by DR0613 - Deinococcus radiodurans
An01g06780	Title: similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens
An01g06790	Function: M. musculus Ank3 is an epithelial ankyrin that is involved in the polarized distribution of many integral membrane proteins. ankyrins act as protein linker between the integral membrane proteins and the spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Remark: the M. musculus homolog Ank3 is significantly shorter.; Title: similarity to ankyrin 3 (splice form 4) - Mus musculus; cytoskeleton
An01g06800	Catalytic activity: N-acylsphingosine + H(2)O <=> a fatty acid + sphingosine.; Function: the S. cerevisiae homolog YPC1 encodes an alkaline ceramidase activity responsible for the breakdown of dihydroceramide and phytoceramide but not unsaturated ceramide. Ypc1p also has reverse activity, catalyzing synthesis of phytoceramide from palmitic acid and phytosphingosine.; Title: strong similarity to alkaline ceramidase Ypc1 - Saccharomyces cerevisiae
An01g06810	Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae
An01g06820	Function: the F. oxysporum homolog CYP505 encodes a membrane-bound fatty acid (omega-1-omega-3) hydroxylase. the physiological roles of the terminal hydroxylation of fatty acids are essentially unknown.; Localization: native F. oxysporum P450foxy was exclusively recovered in the membrane fraction of the fungal cells.; Remark: N- and C-terminal homologies respectively suggest that F. oxysporum P450foxy is a fused protein of P450 and its reductase.; Similarity: F. oxysporum P450foxy is the eukaryotic counterpart of bacterial P450BM3, but it is a unique cytochrome P450 in that it is self-sufficient, which means that it can complete its function without the aid of other proteinaceous components such as NADPH-cytochrome P450 oxidoreductase (referred to as P450reductase).; Title: strong similarity to fatty acid omega-hydroxylase (P450foxy) CYP505 - Fusarium oxysporum
An01g06830	Function: the S. cerevisiae TSC10 gene was found to encode 3-ketosphinganine reductase, the enzyme that catalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sphingolipids.; Remark: an alternative gene name for the S. cerevisiae homolog TSC10 is YBR265w.; Title: similarity to 3-ketosphinganine reductase Tsc10 - Saccharomyces cerevisiae
An01g06840	Function: the S. cerevisiae homolog FAT2 encodes a putative acyl-CoA synthetase that may be involved in peroxisomal fatty acid metabolism.; Induction: expression of S. cerevisiae Fat2p is highly inducible by oleic acid.; Remark: alternative gene names for S. cerevisiae FAT2 are PCS60 and YBR222C.; Similarity: high similarity to the Escherichia coli long chain acyl-CoA synthetase.; Title: strong similarity to acid-CoA ligase Fat2 -Saccharomyces cerevisiae; peroxisome
An01g06850	Catalytic activity: 4-hydroxybutanoate + NAD(+) <=> succinate semialdehyde + NADH; Pathway: butanoate metabolism.; Title: similarity to 4-hydroxybutyrate dehydrogenase - Alcaligenes eutrophus
An01g06860	Title: strong similarity to hypothetical protein Fum9p - Gibberella moniliformis
An01g06870	Title: strong similarity to hypothetical protein Fum8p - Gibberella moniliformis
An01g06880	Title: similarity to dihydroflavonol 4-reductase BAA12723.1 - Rosa hybrid cultivar; See PMID 8528604
An01g06890	Similarity: the ORF is shorter than pesA of M. anisopliae (540 compared to 5157 amino acids).; Similarity: the ORF shows similarity to peptide and toxin synthetases of different species.; Title: similarity to peptide synthase pesA -Metarhizium anisopliae; See PMID 8964498
An01g06900	Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498
An01g06910	Function: in S. cerevisiae expressed CYP94A5 from Nicotiana tabacum is able to catalyze the oxidation of fatty acids to the omega-alcohol and to the corresponding diacid.; Title: strong similarity to cytochrome P450 CYP94A5 - Nicotiana tabacum; See PMID 11358528
An01g06920	Title: strong similarity to multidrug resistance protein ABCC2 - Homo sapiens
An01g06930	Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619
An01g06940	Title: strong similarity to hypothetical transmembrane transport protein SCC30.17c - Streptomyces coelicolor
An01g06950	Remark: the nearby located ORF An01g06930 is also homolog to polyketide synthase FUM5.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619
An01g06960	Title: strong similarity to hypothetical phosphatidyl synthase SPAC22A12.08c - Schizosaccharomyces pombe
An01g06970	Catalytic activity: ARA1 of S. cerevisiae catalyzes the reaktion D-arabinose + NAD(P)(+) <=> D-arabinono-1,4-lactone + NAD(P)H.; Complex: ARA1 of S. cerevisiae is a heterodimer of a heavy chain and a light chain.; Function: ARA1 of S. cerevisiae catalyzes the oxidation of D-arabinose, L-xylose, L-fucose and L-galactose in the presence of NADP(+).; Remark: YBR149W and YBR1127 are alternative names for ARA1.; Similarity: ARA1 of S. cerevisiae belongs to the aldo/keto reductase family.; Similarity: shows similarity to several known and hypothetical oxidoreductases with different specificities.; Title: strong similarity to D-arabinose dehydrogenase Ara1 - Saccharomyces cerevisiae; See PMID 9920381
An01g06990	Remark: blastp matches are unspecific.
An01g07000	Function: ERG24 of S. cerevisiae reduces the c14=c15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol.; Pathway: ERG24 of S. cerevisiae is involved in ergosterol biosynthesis.; Repression: ERG24 of S. cerevisiae is inhibited by the morpholine antifungal drug fenpropimorph.; Similarity: ERG24 of S. cerevisiae belongs to the erg4/erg24 family; Title: strong similarity to C-14 sterol reductase Erg24 - Saccharomyces cerevisiae; See PMID 8125337; See PMID 1418625
An01g07010	Remark: the orf encoded protein also shows weak similarity to human ovarian tumor EST fragment encoded protein 82.; Similarity: only the N-terminal 100 aminoacids show similarity to the N-terminal 100 aminoacids SPBC18H10. 07 of S. pombe.; Title: similarity to hypothetical protein SPBC18H10.07 - Schizosaccharomyces pombe
An01g07020	Similarity: similarities to other are mainly based on repetetive structures.; Title: similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe; nucleus
An01g07030	Catalytic activity: yiaE of E. coli catalizes the reduction of 2, 5-diketo-D-gluconate to 5-keto-D-gluconate,2-keto-D-gluconate (2KDG) to D-gluconate,2-keto-L-gulonate to L-idonate with NADPH as a preferred electron donor.; Title: strong similarity to 2-ketoaldonate reductase yiaE - Escherichia coli; See PMID 9811658
An01g07040	Title: similarity to hypothetical protein SPAC30D11.09 - Schizosaccharomyces pombe
An01g07050	Function: the gro-1 gene, together with the gop-1,gop-2, gop-3 and hap-1 genes enables study of a physiological clock; Similarity: shows similarity to GOP-2 protein of C. elegans from patent Y02529.; Title: strong similarity to hypothetical protein SPBC119.15 - Schizosaccharomyces pombe
An01g07070	Catalytic activity: GUK1 of B. taurus catalyzes the reaction ATP + GMP = ADP + GDP:; Function: GUK1 of B. taurus is essential for recycling GMP and indirectly, cGMP.; Remark: a putative frameshift results in an premature STOP codon.; Similarity: GUK1 of B. taurus shows similarity to other guanylate kinases:; Title: strong similarity to guanylate kinase GUK1 -Bos taurus [putative frameshift]; putative frameshift; See PMID 8243671
An01g07080	Remark: similarity of the ORF encoded protein to similar proteins is mainly based on repetitive amino acids.
An01g07090	Remark: the similarity of the ORF encoded protein to similar proteins in mainly based on repetitive amino acids.
An01g07100	Catalytic activity: Glutathione transferases catalize the reaction RX + glutathione = HX + R-S-glutathione, X may be a sulfate, nitrite or halide group, and R may be an aliphatic, aromatic or heterocyclic group.; Function: the glutathione transferase from patent Y05537 is involved in herbicide metabolism.; Title: strong similarity to subunit TaGST1 from patent WO9914337-A2 - Triticum aestivum
An01g07110	Title: weak similarity to hypothetical protein encoded by An14g00090 - Aspergillus niger
An01g07120	Catalytic activity: 5-oxo-L-prolinases catalize the reaktion of ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate.; Function: 5-oxo-L-prolinases are involved in the cleavage of glutathion.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290; See PMID 9516961
An01g07130	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; EC:1.14.13.1; Remark: alternate name = salicylate hydroxylase.; Remark: the enzyme of Pseudomonas putida is an external flavoprotein monooxygenase, which uses NADH as the external reductant.; Title: strong similarity to salicylate 1-monooxygenase sal1 - Pseudomonas putida; See PMID 1917904
An01g07140	Function: the transcription factor regulates the nmt1 promoter in fission yeast; mnt1 is also repressed by thiamine.; Remark: strong similarity only over the N-terminal part of the protein.; Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491
An01g07150	Function: CYHR of C. maltosa confers resistance to cycloheximide.; Remark: CYHR of C. maltosa is a transmembrane protein and probably a transporter.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An01g07160	Title: strong similarity to tubulin-folding cofactor E - Homo sapiens
An01g07170	Remark: component of U2 snRNP in H. sapiens.; Remark: protein in H. sapiens is about two fold longer than in fungi.; Remark: subunit of the mammalian splicing factor SF3a.; Title: strong similarity to spliceosome-associated protein SAP62 - Homo sapiens; nucleus; See PMID 9016565
An01g07180	Title: strong similarity to serine/threonine kinase cot-1 - Neurospora crassa; See PMID 9680960
An01g07190	Complex: Tim54 of S. cerevisiae forms together with Tim22 the TIM22. 54 complex in the mitochondrial inner membrane.; Function: Tim54 of S. cerevisiae is a component of a complex neccessary for insertion of imported proteins in the mitochondrial inner membrane.; Remark: the TIM23. 17 complex is required for translocation of proteins across the inner membrane,whereas TIM22. 54 is required for insertion of proteins in the mitochondrial inner membrane.; Title: strong similarity to component of the translocase of mitochondrial inner membrane Tim54 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9412462; See PMID 10637294
An01g07200	EC:2.4.1.-; Remark: located in cytosol and in nucleus in Rattus norvegicus.; Title: similarity to N-acetylglucosaminyltransferases chain p110 - Rattus norvegicus; cytoplasm
An01g07210	Remark: only partial similarities.; Title: similarity to caffeine-induced death protein cid2p - Schizosaccharomyces pombe; See PMID 10036242; See PMID 10757807
An01g07220	Function: MutM protein removes the oxidatively damaged DNA base product, 8-oxoguanine (GO) in Thermus thermophilus.; Title: similarity to formamidopyrimidine-DNA glycosidase MutM - Thermus thermophilus; See PMID 9461446; See PMID 10731660
An01g07230	Title: similarity to hypothetical protein DRB0099 -Deinococcus radiodurans
An01g07240	Title: similarity to NADP-reducing hydrogenase D chain - Desulfovibrio fructosovorans; See PMID 7751270
An01g07250	Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Function: catalyses DNA-template-directed extention of the 3'- end of an RNA strand by one nucleotide at a time.; Remark: ABC10 alpha of S. cerevisiae is also called RPB12 or RPC10.; Title: strong similarity to 7.7 kD subunit of DNA-directed RNA polymerase II Abc10-alpha - Saccharomyces cerevisiae; nucleus; See PMID 1617300
An01g07260	Catalytic activity: N-(5-phospho-D-ribosyl)anthranilate + pyrophosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.; Title: strong similarity to anthranilate phosphoribosyltransferase - Saccharomyces cerevisiae; See PMID 2428012
An01g07270	Remark: partial similarities over the C-terminus.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml11 - Saccharomyces cerevisiae; See PMID 9162110
An01g07280	Catalytic activity: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Function: the L. monocytogenes enzyme plays a role during infections of mammalian cells.; Remark: the database proteins are app. 130 aa shorter.; Title: similarity to precursor of phosphatidylinositol-specific phospholipase C - Listeria monocytogenes; See PMID 8331063; See PMID 9367761; See PMID 1662763
An01g07290	Remark: the ORF has an unusual exon/intron structure for A. niger.
An01g07300	Catalytic activity: ATP + D-gluconate = ADP + 6-phospho-D-gluconate.; Remark: alternate name = gluconate kinase 2 in Escherichia coli.; Title: strong similarity to gluconokinase gntV -Escherichia coli; See PMID 8655507; See PMID 9151423
An01g07310	Remark: questionable gene structure.
An01g07320	Function: protein performs a role in the delivery of proteins to the vacuole.; Remark: the embryogenesis protein H beta 58 protein of the mouse is also named vacuolar sorting protein (see AC: AB015476).; Title: strong similarity to embryogenesis protein H beta 58 - Mus musculus
An01g07330	Function: the guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP.; Remark: only partial similarity over the N-Terminus.; Title: similarity to brefeldin A-inhibited guanine nucleotide-exchange protein 2 - Homo sapiens; See PMID 10212200
An01g07350	Function: Mms2 and Ubc13 form a complex required for a novel polyubiquitin chain assembly in yeast.; Function: part of the error-free postreplication repair pathway.; Title: strong similarity to ubiquitin conjugating enzyme like protein Mms2 - Saccharomyces cerevisiae; nucleus; See PMID 9576943; See PMID 9705497; See PMID 10924462
An01g07360	Title: weak similarity to hypothetical protein B7F18.80 - Neurospora crassa
An01g07370	Title: strong similarity to PTD013 - Homo sapiens
An01g07380	Remark: the S. pombe protein possibly interacts with protein phosphatase two C.; Title: strong similarity to hypothetical protein SPBC16D10.01c - Schizosaccharomyces pombe
An01g07390	Remark: sir proteins from Kluyveromyces lactis are essential for transcriptional silencing of mating type loci.; Title: similarity to regulator protein SIR2 -Kluyveromyces marxianus; nucleus; See PMID 8007956; See PMID 9539421
An01g07400	Remark: last exon seems to be in the wrong frame,maybe due to the contig end.; Title: strong similarity to hypothetical protein YOL124c - Saccharomyces cerevisiae
An01g07410	Remark: only partial similarities.; Title: weak similarity to histidine triad protein Hnt1 - Saccharomyces cerevisiae; See PMID 10958787; See PMID 11805111
An01g07420	Complex: cyclin B (nimE) of E. nidulans interacts with nimTcdc25 tyrosine phosphatase.; Function: cyclin B (nimE) of E. nidulans is a subunit of the mitotic progression factor (MPF).; Similarity: the predicted A. niger protein shows strong similarity to cyclin B (nimE) of E. nidulans.; Title: strong similarity to cyclin B nimE -Aspergillus nidulans; See PMID 9552417; See PMID 1534750
An01g07430	Function: ribosomal yeast protein l2 is a 37-kDa polypeptide component of the mitochondria 54 S large ribosomal subunit.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9079633
An01g07445	Remark: the encoded protein contains a Zn(2)-Cys(6) binuclear cluster.; Title: similarity to transcriptional regulator Cat8 - Saccharomyces cerevisiae; nucleus; See PMID 7891685
An01g07450	Remark: protein is involved in acetamide and acetate utilisation in A. nidulans.; Remark: the cDNA SB011195. p1 possesses additional sequences (the first intron) but because of two stop-codons within this intron and because of the homologies to other proteins this sequences were not added to the ORD coding sequence.; Similarity: the ORF shows similarity to some transcription factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An01g07460	Function: the protein is responsible for vegetative incompatibility in Podospora anserina.; Remark: the Podospora anserina protein is N-terminal 800 aa longer than the A. niger protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402
An01g07470	Remark: RNaseP of H. sapiens is a ribonucleoprotein that cleaves tRNA precursors to generate the 5' termini of the mature tRNAs.; Similarity: the ORF is longer than RNaseP of H. sapiens and the similarity between the two proteins extends solely over a stretch of ca. 60 amino acids.; Title: weak similarity to Ribonuclease P protein subunit p40 RNaseP - Homo sapiens; See PMID 7514716
An01g07480	Function: dna2 plays an essential role in Okazaki fragment metabolism in Schizosaccharomyces pombe.; Remark: the Aspergillus protein is N-terminal about 300 aa shorter than the S. pombe homolog.; Title: strong similarity to DNA binding protein dna2p - Schizosaccharomyces pombe; nucleus; See PMID 10880469
An01g07490	Title: similarity to hypothetical protein CAF06129.1 - Neurospora crassa
An01g07500	Title: strong similarity to hypothetical protein CAF06125.1 - Neurospora crassa
An01g07510	Catalytic activity: nitrilases catalyze a nitrile + H(2)O <=> a carboxylate + NH(3).; Similarity: the ORF shows similarity to several nitrilases from different species and to the N-terminal part of NitFhit from Caenorhabditis elegans, which displays nitrilase activity.; Title: similarity to nitrilase fusion protein NitFhit - Caenorhabditis elegans
An01g07520	Function: the S. pombe homolog is an essential protein directly or indirectly implicated in mitotic control.; Remark: S. pombe cells disrupted in the dis3+ gene are unable to germinate and fail in cell division.; Title: strong similarity to mitotic control protein dis3p - Schizosaccharomyces pombe; nucleus; See PMID 1944266
An01g07530	Function: the M. auratus homolog catalyzes the H+/Lactate-cotransport; facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates.; Localization: integral membrane protein (probable).; Title: similarity to monocarboxylate transporter MCT2 - Mesocricetus auratus
An01g07550	Title: similarity to androgen receptor coactivator ARA55 - Homo sapiens; See PMID 10075738
An01g07570	Function: defects in Liz1p of S. pombe blocks cell cycle progression in G2 when ribonucleotide reductase activity is inactivated.; Similarity: the predicted A. niger protein shows strong similarity to Liz1p of S. pombe and other transmembrane transporter proteins.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; plasma membrane; See PMID 9950674
An01g07580	Remark: protein may be a methyltransferase-like protein similar to human and mouse proteins.; Title: strong similarity to hypothetical protein YDL201w - Saccharomyces cerevisiae
An01g07590	Title: strong similarity to hypothetical protein W02A11.2 - Caenorhabditis elegans
An01g07600	Title: similarity to pax transcription activation domain interacting protein PTIP - Mus musculus; nucleus; See PMID 10908331
An01g07615	Remark: the ORF is truncated due to the contig border.; Remark: the missing N-terminal coding sequence is encoded in An01g07630 on the adjacent contig.; Title: strong similarity to hypothetical host-specific AK-toxin related protein CAB91703.2 -Neurospora crassa [truncated ORF]
An01g07630	Remark: the ORF is truncated due to the contig border.; Remark: the missing N-terminal coding sequence is encoded in An01g07615 on the adjacent contig.; Title: strong similarity to hypothetical host-specific AK-toxin related protein CAB91703.2 -Neurospora crassa [truncated ORF]
An01g07640	Remark: alternate names = hypothetical protein LPG21w.; Title: similarity to hypothetical membrane protein YPL087w - Saccharomyces cerevisiae
An01g07650	Remark: substrates of the nematode Onchocerca volvulus proteins are small ions.; Title: similarity to MRS3/MRS4 class mitochondrial solute carrier - Onchocerca volvulus; localisation:mitochondrion
An01g07660	Remark: protein may be an EF-hand-like calcium-binding protein.; Title: similarity to hypothetical protein B7F18.80 -Neurospora crassa
An01g07680	Title: similarity to hypothetical protein encoded by An11g02490 - Aspergillus niger
An01g07690	Remark: weak partial similarities to human mRNA for alpha-1 chain of collagen IV.
An01g07700	Function: pth11 of M. grisea is involved in host surface recognition.; Remark: pth11 of M. grisea is probably membrane associated.; Similarity: the ORF is about 260 amino acids shorter than pth11 of M. grisea.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g07710	Remark: partial similarity to S. coelicolor hydroxyacyl-CoA dehydrogenase (TREMBL:SCHCOADH_5).
An01g07720	Function: omtB of A. parasiticus converts demethylsterigmatocystin to sterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: omtB of A. parasiticus belongs to the aflatoxin biosynthetic gene cluster.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 6798444; See PMID 10806361
An01g07730	Title: weak similarity to precursor of protein TcSL-2 - Toxocara cani; See PMID 7629180
An01g07740	Remark: the ORF is short in length.
An01g07750	Remark: Alternate names = protein B7F18. 60; Title: similarity to hypothetical prefoldin subunit 1 - Neurospora crassa
An01g07760	Similarity: shows similarity to several oxygenases.; Title: strong similarity to hypothetical protein F12A12.10 - Arabidopsis thaliana
An01g07770	Title: strong similarity to hypothetical protein EAA59879.1 - Aspergillus nidulans
An01g07780	Title: questionable ORF
An01g07790	Remark: a putative sequencing error results in an premature STOP codon.; putative sequencing error
An01g07810	Function: The S. pombe homolog is required for nitrogen starvation-induced sexual development.; Title: strong similarity to protein rcd1p -Schizosaccharomyces pombe; See PMID 9447985
An01g07820	Title: similarity to hypothetical Pto kinase interactor F28B23.17 - Arabidopsis thaliana
An01g07830	Function: in S. pombe Ste11 protein regulates positively transcription of the mating type genes, matP and matM, and the mei2 gene, which is essential for commitment to meiosis.; Function: in S. pombe expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation.; Regulation: in S. pombe methionine and nitrogen starvation reduce the intracellular cAMP pool and induce the expression of at least two cAMP-repressible genes,including fbp1 and ste11.; Similarity: S. pombe ste11 encodes a member of the family of HMG-box proteins.; Similarity: similarity is from central region of predicted A. niger protein to N-terminal 100 aa of S. pombe ste11.; Title: similarity to transcription factor ste11p -Schizosaccharomyces pombe; See PMID 1657709
An01g07840	Remark: no transmembrane regions were prdicted for the ORF.; Similarity: similarity of predicted A. niger protein is confined to central region of G. gallus cKv1. 4(m),which is 200 aa longer.; Title: weak similarity to potassium channel Shaker alpha subunit variant cKv1.4(m) - Gallus gallus; See PMID 10095080
An01g07850	Title: similarity to hypothetical protein SPBP23A10.09 - Schizosaccharomyces pombe
An01g07860	Function: the protein also shows similarity to S. hamata shst2 which encodes a high-affinity H+/sulfate cotransporter that mediates the uptake of sulfate by plant roots from low concentrations of sulfate in the soil solution.; Title: strong similarity to hypothetical membrane transport protein YGR125w - Saccharomyces cerevisiae
An01g07870	Function: sea lamprey neurofilaments (NFs) are unique in being homopolymers of a single 180 kDa subunit (NF-180).; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; cytoskeleton; See PMID 7770000
An01g07890	Function: Disruption of cpcA in A. niger resulted in a strain which is sensitive towards 3-aminotriazole and fails to respond to amino acid starvation.; Gene-ID: cpcA; Remark: cpcA of Aspergillus niger was cloned by complementation of a S. cerevisiae delta gcn4 mutant strain.; See PMID 9004217
An01g07900	Gene-ID: cpcA; Remark: the second exon is N-terminal two aminoacids longer than the published sequence.; Remark: two putative frameshift leading to premature STOP codons found.; nucleus; putative frameshift; See PMID 9004217
An01g07910	EC:6.3.5.4; Title: similarity to glutamine-hydrolyzing asparagine synthase - Arabidopsis thaliana; See PMID 9881155
An01g07920	Remark: appearance of novel reticular membrane structures as well as an accumulation of 40- to 50-nm-diameter vesicles suggested that Vps9p may be required for the consumption of transport vesicles containing vacuolar protein precursors.; Title: strong similarity to vacuolar protein sorting-associated protein Vps9 - Saccharomyces cerevisiae; See PMID 8628304
An01g07930	Title: strong similarity to hypothetical protein encoded by An11g05030 - Aspergillus niger
An01g07940	Remark: blastp hits are caused by repetetive sequence motives.; Title: weak similarity to hypothetical protein Y38B5A.a - Caenorhabditis elegans
An01g07950	Title: similarity to hypothetical protein CAD70322.1 - Neurospora crassa
An01g07960	Title: strong similarity to hypothetical protein CAD70321.1 - Neurospora crassa
An01g07970	Title: similarity to hypothetical protein encoded by An06g02140 - Aspergillus niger
An01g07980	Title: strong similarity to EST SEQ ID NO:4248 from patent WO200056762-A2 - Aspergillus niger
An01g07990	Title: similarity to hypothetical protein encoded by An09g04200 - Aspergillus niger
An01g08000	Function: het-e1 of P. anserina is involved in vegetative incompatibility.; Remark: co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Remark: het-e1 of P. anserina is transducin-like.; Remark: the reactivity of the het-e1 of P. anserina depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: strong similarity to vegetative incompatibility gene het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787
An01g08010	Function: CCC1 of S. cerevisiae is a transporter that effects the accumulation of iron and Mn(2+) in vacuoles.; Remark: CCC1 of S. cerevisiae is involved in the transfer of iron from the cytosol to the vacuole.; Title: strong similarity to iron and manganese transporter Ccc1 - Saccharomyces cerevisiae; vacuole; See PMID 11390404
An01g08030	Pathway: the protein of patent W55817 from S. roseofulvus is involved in the polyketide pathway of frenolicin biosynthesis.; Similarity: frnR of S. roseofulvus encodes a putative cyclase/dehydrase with similarity to beta-lactamase.; Similarity: shows homology to the protein patent database entry GENESEQPROT:W55817.; Similarity: the protein sequence of patent W55817 is identical to the product of the frnR gene of the frenolicin biosynthesis gene cluster of S. roseofulvus.; Title: similarity to frenolicin gene cluster protein 18 from patent JP10094395-A - Streptomyces roseofulvus
An01g08040	Similarity: the C-terminus contains a domain with similarity to the RNA polymerase II mediator subunit ROX3 of S. cerevisiae (PubMed 1656237;8995225).; Similarity: the N-terminus shows deliberate matches to a variety of serine-rich proteins from diverse species.; Similarity: the N-terminus shows weak similarity to the proline-rich protein VRP1 (verprolin) of S. cerevisiae involved in cytoskeleton organization (PubMed 7968536).; Title: similarity to hypothetical protein B11E5.120 - Neurospora crassa
An01g08050	Function: UaY of A. nidulans binds to the consensus sequence 5'-tcggnnnnnnccga-3'.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Similarity: UaY of A. nidulans contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7602582; See PMID 7729421
An01g08060	Function: UaY of A. nidulans binds to the consensus sequence 5'-tcggnnnnnnccga-3'.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Similarity: UaY of A. nidulans contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7602582; See PMID 7729421
An01g08070	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An01g08080	Title: strong similarity to hypothetical protein SPAC32A11.02c - Schizosaccharomyces pombe
An01g08090	Catalytic activity: aminoimidazole ribonucleotide carboxylases catalyse the reaction,1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarbox ylate => 1-(5-phospho-D-ribosyl)-5-aminoimidazole + CO2.; Function: C. glabrata ADE2 catalyses a central step in de novo purine biosynthesis.; Remark: the C. glabrata ADE2 gene encodes aminoimidazole ribonucleotide (AIR) carboxylase.; Title: strong similarity to aminoimidazole ribonucleotide carboxylase ADE2 - Candida glabrata; See PMID 9500840; See PMID 9602176
An01g08100	Title: similarity to hypothetical protein CAE81998.1 - Neurospora crassa
An01g08110	Remark: atp7a (Menkes protein) in Mus musculus is localised in the plasma membrane of liver peroxisomes.; Title: strong similarity to Cu(2+)-transporting P-type ATPase Atp7a - Mus musculus; plasma membrane; See PMID 9687544; See PMID 10332039
An01g08120	Remark: ACOB is one of the preinduction genes (acts before induction of sporulation) in Aspergillus nidulans.; Title: strong similarity to protein ACOB -Aspergillus nidulans; See PMID 7551046
An01g08130	Remark: expression of RAX1 from S. cerevisiae is required for the delivery of Rax2-GFP to the cell surface (see PUBMED entry 11110666).; Similarity: the predicted A. niger protein shows strong similarity to hypothetical proteins SPAC23G3. 05c from S. pombe and YOR301w (RAX1) from S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC23G3.05c - Schizosaccharomyces pombe
An01g08140	Remark: blastp hits are caused by repetetive sequence motives.
An01g08150	Catalytic activity: carbonyl reductases catalyse the reaction, R-CHOH-R' + NADP+ = R-CO-R' + NADPH; Function: human carbonyl reductase is envolved in prostaglandin- and leukotrine-metabolism in H. sapiens.; Title: similarity to carbonyl reductase CBR - Homo sapiens; See PMID 1921984
An01g08160	Complex: in S. cerevisiae Gcn5 with Ada and Hac1is part of a large multimeric histone acetyltransferase complex.; Function: S. cerevisiae Gcn5 is required for transcriptional activation.; Remark: GCN5 is a lys14 specific histone H3 acetyltransferase in S. cerevisiae.; Title: strong similarity to histone acetyltransferase Gcn5 - Saccharomyces cerevisiae; nucleus; See PMID 10430845; See PMID 1396595
An01g08170	Complex: yeast Rad1-Rad10 form a complex.; Function: in yeast Rad1-Rad10 form a complex with endonuclease activity, incising damaged DNA strands on the 5'-side of the lesion.; Title: strong similarity to DNA repair endonuclease rad1p - Schizosaccharomyces pombe; nucleus; See PMID 9660799; See PMID 10915862; See PMID 1563349
An01g08180	Complex: RINT-1 specifically binds to Rad50 only during late S and G(2)/M phases.; Complex: S. cerevisiae RAD50 forms different complexes to act specifically in DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiosis.; Complex: the Mre11-Rad50 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity.; Function: the RAD50 gene of S. cerevisiae is required for chromosome synapsis and recombination during meiosis and for repair of DNA damage during vegetative growth.; Title: strong similarity to DNA-repair ATPase Rad50 - Saccharomyces cerevisiae; nucleus; See PMID 2659437; See PMID 10892749; See PMID 10915866; See PMID 11029422; See PMID 11096100
An01g08190	Similarity: shows weak similarity to several bacterial aminopeptidases.; Title: weak similarity to hypothetical aminopeptidase pepA - Mycobacterium tuberculosis
An01g08200	Remark: similarity of predicted A. niger protein to human breast tumour-associated protein 71 was discovered using blastp against the PATENTPROT database.; Remark: the protein sequence of human breast tumour-associated protein 71 is a fragment derived from an EST.; Title: weak similarity to EST derived breast tumour-associated protein 71 from patent DE19813835-A1 -Homo sapiens
An01g08210	Function: F. solani PBP is essential for induction of the cutinase gene.; Similarity: F. solani PBP and the predicted A. niger protein share a fungal Cys6Zn2 binuclear cluster DNA-binding domain.; Title: strong similarity to transcription factor PBP - Fusarium solani; nucleus; See PMID 7744822
An01g08220	Title: strong similarity to hypothetical membrane protein YNL010w - Saccharomyces cerevisiae
An01g08230	Similarity: similarity is between the N-terminal regions of the predicte A. niger protein and S. cerevisiae GCD14.; Similarity: the N-terminal region of the predicted A. niger protein shows similarity to different methyltransferases.; Title: weak similarity to methyltransferase Gcd14 -Saccharomyces cerevisiae; See PMID 10330157
An01g08240	Complex: by two-hybrid assay and in vitro S. cerevisiae yTaf(II)19p and Not5p interact.; Complex: the S. cerevisiae Ccr4-Not complex (1 mDa in size), consists of the proteins Ccr4, Caf1, and Not1 to Not5.; Function: S. cerevisiae CCR4 is required for positive and negative regulation of a number of genes involved in nonfermentative growth, including glucose-repressible ADH2.; Function: the S. cerevisiae Ccr4-Not complex likely represses transcription by inhibiting factors more specifically required for promoters lacking a TATA sequence like the yTaf(II)19 subunit of TFIID.; Regulation: the transcriptional activation ability of S. cerevisiae CCR4 is glucose regulated.; Title: similarity to transcription regulator Ccr4 -Saccharomyces cerevisiae; nucleus; See PMID 8007957; See PMID 10490603; See PMID 10864925
An01g08250	Remark: blastp shows significant similarity (43% identity) between predicted A. niger protein and A. sulcata LWamide but due to shortness of both peptides the probability is low (p=1,2).; Remark: literature concerning LWamide of A. sulcata is not available via PubMed.; Title: similarity to precursor of LWamide neuropeptide - Anemonia sulcata
An01g08260	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Remark: blastp with the predicted A. niger protein only retrieves random hits.; Title: questionable ORF
An01g08280	Title: strong similarity to hypothetical protein CAC28582.1 - Neurospora crassa
An01g08290	Title: weak similarity to hypothetical protein CG6115 - Drosophila melanogaster
An01g08300	Title: similarity to hypothetical conserved protein VC1938 - Vibrio cholerae
An01g08310	Title: strong similarity to hypothetical protein CAC28577.2 - Neurospora crassa
An01g08360	Remark: the similarity is only in the hydroxyproline-rich region.; Title: similarity to hydroxyproline-rich microfilarial sheath protein - Brugia malayi; See PMID 7637719
An01g08370	Remark: transcription factor TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements.; Title: similarity to transcription factor IIIC 95K chain Tfc1 - Saccharomyces cerevisiae; See PMID 2052571; See PMID 1737746
An01g08380	Remark: Dibenzothiophene (DBT) is representative of a broad range of sulfur heterocycles found in petroleum that are recalcitrant to desulfurization via HDS.; Remark: Rhodococcus sp. strain IGTS8 has the ability to convert DBT to 2-hydroxybiphenyl (HBP) with the release of inorganic sulfur. The conversion of DBT to HBP is catalyzed by a multienzyme pathway consisting of two monooxygenases and a desulfinase.; Remark: the development of biocatalytic desulfurization of petroleum fractions may allow its use in place of conventional hydrodesulfurization (HDS).; Title: similarity to NADH-dependent FMN oxydoreductase dszD - Rhodococcus erythropolis; See PMID 9634856
An01g08390	Remark: mitochondrial ribosomal proteins (MRPs) are the counterparts in that organelle of the cytoplasmic ribosomal proteins in the host.; Remark: the mitochondrial ribosome of the yeast S. cerevisiae contains 13 large subunit proteins.; Title: similarity to ribosomal protein of the large subunit Mrpl36 - Saccharomyces cerevisiae; See PMID 9151978; See PMID 9445368
An01g08400	Remark: VPSS/GRD2, encodes a hydrophilic protein similar to human sorting nexin-1, a protein involved in trafficking of the epidermal growth factor receptor.; Remark: Vps5p is required for retrieval of membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus.; Title: strong similarity to sorting nexin-1-like protein Vps5 - Saccharomyces cerevisiae; See PMID 9175702
An01g08410	Remark: patent EP892050-A2.; Remark: useful as diagnostic reagents and for prevention and treatment of inflammatory diseases, cancer and Parkinson's disease.; Title: strong similarity to polypeptide HFIZG53 from patent EP892050-A2 - Homo sapiens
An01g08420	Remark: Secretory proteins become folded by the action of a number of molecular chaperones soon after they enter the endoplasmic reticulum (ER). In mammalian cells,the ER membrane protein calnexin has been shown to be a molecular chaperone involved in the folding of secretory proteins and in the assembly of cell surface receptor complexes.; Title: strong similarity to calcium-binding protein precursor cnx1p - Schizosaccharomyces pombe; See PMID 7621821; See PMID 10597630; See PMID 10878246
An01g08430	Catalytic activity: 2-Methyl-3-oxopropanoate + CoA + NAD+ = Propanoyl-CoA + CO2 + NADH.; Pathway: valine, leucine and isoleucine degradation; propanoate metabolism.; Remark: MMSDH clearly belongs to a superfamily of aldehyde dehydrogenases and is closely related to betaine aldehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, and class 1 and 2 aldehyde dehydrogenases.; Remark: the enzyme is active with malonate semialdehyde and consumes both stereoisomers of methylmalonate semialdehyde, implicating a single semialdehyde dehydrogenase in the catabolism of valine,thymine, and compounds catabolized by way of beta-alanine.; Title: strong similarity to methylmalonate-semialdehyde dehydrogenase MMSDH - Rattus norvegicus; See PMID 2768248; See PMID 1527093
An01g08440	Remark: weak similarity to the C-terminal domain of the glucan-binding protein - Streptococcus mutans.; Title: strong similarity to hypothetical protein encoded by An13g02980 - Aspergillus niger
An01g08450	Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein.; Remark: babo is not required during embryogenesis but is essential for proper pupation and adult viability. Among findings on babo function, babo primarily regulates cell proliferation and has only minimal effects on patterning.; Title: weak similarity to baboon babo - Drosophila melanogaster; deleted EC_number 2.7.1.37
An01g08460	Function: Alg12 from S. cerevisiae is part of the dolichol pathway.; Function: Alg12 from S. cerevisiae is responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2.; Function: The S. cerevisiae alg12 deletion mutant accumulates oligosaccharide lipid with a Man(7)GlcNAc(2) oligosaccharide.; Title: strong similarity to the mannosyltransferase Alg12 - Saccharomyces cerevisiae; See PMID 10336995; See PMID 12460943
An01g08465	Title: strong similarity to hypothetical protein SPAC19A8.09 - Schizosaccharomyces pombe
An01g08470	Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol.; Remark: acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. also acts on AMP-ubiquitin.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase UBP1 - Pichia anomala; See PMID 1883836; See PMID 10635554; See PMID 10933821
An01g08490	Catalytic activity: ATP + L-histidine + tRNA(His) = AMP + pyrophosphate + L-histidyl-tRNA(His).; Localization: might encode the cytoplasmic and mitochondrial protein.; Pathway: aminoacyl-tRNA biosynthesis.; Remark: histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA,which is essential for the incorporation of histidine into proteins.; Title: strong similarity to histidine--tRNA ligase Hts1 - Saccharomyces cerevisiae; See PMID 3521891; See PMID 10430027
An01g08500	Remark: COQ6 encodes a protein which is involved in the biosynthesis of coenzyme Q (Tzagoloff and Dieckmann,1990).; Similarity: to E. coli ubiH and visC proteins.; Title: strong similarity to monooxygenase Coq6 -Saccharomyces cerevisiae; See PMID 10669875; See PMID 10987383
An01g08510	Remark: the N-terminal part shows similarity to many different proteins of various organisms.
An01g08520	Complex: when expressed in COS7 cells,epitope-tagged sorting nexins SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with receptor tyrosine kinases for EGF, platelet-derived growth factor, and insulin.; Function: SNX4 of S. cerevisiae is a sorting nexin involved in protein sorting.; Remark: the protein contains a conserved domain of approximately 100 amino acids, which was termed the phox homology (PX) domain.; Remark: the systematic genename of SNX4 is YJL036w .; Title: strong similarity to sorting nexin protein Snx4 - Saccharomyces cerevisiae; See PMID 9819414
An01g08530	Catalytic activity: cleavage of -Lys-Arg+ and Arg-Arg+ bonds to process yeast alpha-factor pheromone and killer toxin precursors.; Gene-ID: kexB; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: Secreted yields of foreign proteins may be enhanced in filamentous fungi through the use of translational fusions in which the target protein is fused to an endogenous secreted carrier protein. The fused proteins are usually separated in vivo by cleavage of an engineered Kex2 endoprotease recognition site at the fusion junction.; Remark: a Ca2+-activated subtilisin homologue,containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; See PMID 1367012; See PMID 10618249
An01g08540	Remark: K3OH is involved in metabolism of tryptophan to kynurenic acid (KYNA), which has anticonvulsant and neuroprotective activities, and quinolinic acid (QUIN) which is neurotoxic, and is a target for inhibition of QUIN synthesis.; Remark: patent WO9802553.; Title: strong similarity to kynurenine 3-hydroxylase K3OH from patent WO9802553 - Rattus sp.; See PMID 10672018; See PMID 11080194
An01g08550	Remark: ATR1 allowes gcn4 mutant strains to grow in the presence of aminotriazole.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 9046086
An01g08560	Remark: the ORF encoded protein is N-terminal extended in comparison to S. cerevisiae YGR266w.; Title: similarity to hypothetical protein YGR266w -Saccharomyces cerevisiae
An01g08570	Catalytic activity: NADPH + oxidized thioredoxin <=> NADP(+) + reduced thioredoxin.; Complex: the thioredoxin reductase TrxB from Penicillium chrysogenum forms a homodimer.; Title: strong similarity to thioredoxin reductase TrxB - Penicillium chrysogenum; cytoplasm; See PMID 8106340
An01g08580	Catalytic activity: N1-acetylspermine + O(2) + H(2)O <=> N1-acetylspermidine + 3-amino-propanal + H(2)O(2).; Remark: the polyamine oxidase PAO utilises an FAD cofactor to catalyse the oxidation of the secondary amino groups of spermine and spermidine.; Similarity: the closest manual homologue PAO from Z. mays shows an E-val. of 1e-25.; Title: similarity to polyamine oxidase PAO - Zea mays; See PMID 9598979; See PMID 1366693; See PMID 10368296
An01g08590	Title: strong similarity to hypothetical protein YKR088c - Saccharomyces cerevisiae
An01g08600	Title: similarity to hypothetical protein At2g26280 - Arabidopsis thaliana
An01g08610	Catalytic activity: Citrate <=> acetate + oxaloacetate.; Title: strong similarity to citrate lyase beta chain CitE - Klebsiella pneumoniae; cytoplasm; See PMID 7830578
An01g08620	Title: strong similarity to hypothetical protein SPBC2A9.05c - Schizosaccharomyces pombe
An01g08630	Induction: the mrcA gene product from Streptomyces lavendulae is inducible by mitomycin C.; Title: similarity to protein involved in mitomycin C resistance McrA - Streptomyces lavendulae; See PMID 7517396; See PMID 8917108
An01g08640	Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3).; Function: the hydroxymethylbilane synthase Hem3 from S. cerevisiae catalyzes the tetrapolymerisation of the monopyrrole PBG into the hydroxymethylbilane preuroporphyrinogen.; Induction: the promotor of the S. cer. HEM3 gene has a binding site for Hap2p/Hap3p/Hap4p complex.; Pathway: Hem3 S. cer. is involved in the yeast porphyrin biosynthesis.; Remark: the hydroxymethylbilane synthase from S. cerevisiae is alternativly named porphobilinogen deaminase or pre-uroporphyrinogen synthase.; Title: strong similarity to hydroxymethylbilane synthase Hem3 - Saccharomyces cerevisiae; See PMID 1508149
An01g08660	Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to ankyrin Ank - Drosophila melanogaster [truncated ORF]; See PMID 7937942
An01g08670	Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to nucleolin C23 - Cricetulus griseus; nucleus; See PMID 3470736
An01g08680	Title: weak similarity to regulator protein Gal4 -Saccharomyces cerevisiae
An01g08690	Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: Iron, Tetrahydrobiopterin.; Pathway: the benzoate 4-monooxygenase cytochrome P450 53 (BphA) from A. niger is involved in the phenylalanine metabolism.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 2250647
An01g08700	Function: the CYHR protein from C. maltosa transforms S. cerevisiae to cycloheximide resistance.; Similarity: the ORF encoded protein shows the strongest similarity to the protein of patent JP09009966-A,but this patent does not describe its function clearly enough.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; See PMID 1628836
An01g08710	Remark: the ORF encoded protein has a unusual gene structure and it is much shorter than cnjB from Tetrahymena thermophila.; Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to protein cnjB - Tetrahymena thermophila; See PMID 8233798
An01g08720	Remark: the CDR1 gene from C. albicans was cloned by functional complementation of a PDR5 null mutant of S. cerevisiae.; Similarity: the ORF encoded protein shows the strongest similarity to the AtrA transporter from A. nidulans, which is not enough functionally characterized.; Title: strong similarity to multidrug resistance ATP-binding cassette transporter CDR1 - Candida albicans; See PMID 7614555
An01g08730	Title: weak similarity to gamma-tocopherol methyltransferase from patent WO9904622-A1 - Arabidopsis sp.
An01g08740	Function: the protein product of MJ0720 from Methanococcus jannaschii was found to be alpha-isopropylmalate dehydrogenase (LeuB) and was found to catalyze the NAD-dependent decarboxylation of one isomer of DL-threo-isopropylmalate to 2-ketoisocaproate; thus, it is involved in the biosynthesis of leucine.; Remark: LeuB normally is the gene name for beta-isopropylmalate dehydrogenases (EC 1. 1. 1. 85; e. g. LeuB Corynebacterium glutamicum.; Title: similarity to protein MJ0720 - Methanococcus jannaschii; See PMID 10940051
An01g08760	Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An01g08780	Induction: the HXT1 gene from S. cerevisiae is repressed at high glucose concentrations.; Remark: alternate name for S. cerevisiae Hxt1: YHR094C,Hor4.; Title: strong similarity to high affinity hexose transporter Hxt1 - Saccharomyces cerevisiae; See PMID 9151960; See PMID 2046678
An01g08790	Similarity: the ORF encoded protein shows the strongest similarity to the S. pombe hypothetical proteins SPAC1B3. 16c and SPAC1B3. 15c.; Title: strong similarity to 4-hydroxyphenylacetate transporter hpaX - Escherichia coli; See PMID 9315705
An01g08800	Catalytic activity: ATP + L-glutamate + NH(3) <=> ADP + phosphate + L-glutamine.; Pathway: the glutamine synthetase (GLN1) from S. cerevisiae is involved in glutamate metabolism and nitrogen metabolism.; Remark: the DNA sequence of the ORF is nearly identical to the A. niger EST BE759130.; Similarity: the ORF encoded protein shows stong similarity to the protein described in patent WO8704462-A.; Title: strong similarity to glutamine synthase Gln1 - Saccharomyces cerevisiae; See PMID 2865193
An01g08820	Title: strong similarity to hypothetical protein CAD71053.1 - Neurospora crassa
An01g08830	Title: similarity to hypothetical protein CAD70783.1 - Neurospora crassa
An01g08840	Similarity: the ORF encoded protein also shows strong similarities to B. subtilis conserved hypothetical proteins yoqW and yoaM.; Similarity: the similarities of the ORF encoded protein with a score less than 58. 6 (e. val:1e-07) are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein YMR114c - Saccharomyces cerevisiae
An01g08850	Similarity: the ORF encoded protein and the Aspergillus nidulans CpcB protein are homologues of the activated protein kinase C receptor RACK1 from Rattus norvegicus.; Similarity: the ORF encoded protein shows also very stong similarity to the human WD-repeat protein described in patent WO9521252-A2.; Title: strong similarity to Gbeta like protein cpcB - Aspergillus nidulans; See PMID 10931303
An01g08860	Title: strong similarity to hypothetical protein 12F11.240 - Neurospora crassa
An01g08870	Complex: the Erv25 protein from S. cerevisiae forms a protein complex with Emp24 (another component of COPII-coated vesicles) that can be isolated after chemical cross-linking.; Remark: alternate name for S. cerevisiae Erv25: YML012w.; Similarity: the ORF encoded protein shows also strong similarity to the Haemonchus contortus protein described in patent DE19704024-A1.; Title: strong similarity to component of COPII-coated vesicles Erv25 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8900179; See PMID 10704443
An01g08880	Remark: alternate names for S. cerevisiae MUC1 gene: FLO11 or YIR019c.; Remark: there are no hints for any Muc1 1,4-alpha-glucosidase activity in the literature.; Similarity: the Muc1 protein from S. cerevisiae is a mucin-like protein.; Similarity: the similarities of the ORF encoded protein to Muc1 from S. cerevisiae and the other proteins are mainly based on repetitive structures.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886
An01g08900	Function: the Aspergillus nidulans wetA gene is required for synthesis of cell wall layers that make asexual spores (conidia) impermeable.; Title: strong similarity to regulator protein wetA -Aspergillus nidulans; See PMID 1986246; See PMID 2180753
An01g08910	Title: weak similarity to chromodomain-helicase-DNA-binding protein CHD-1 - Mus musculus; See PMID 7739555; See PMID 8460153
An01g08920	Remark: Scp1='S. cerevisiae CalPonin'.; Similarity: the n-terminal part of the ORF encoded protein (~200aa) shows strong similarity to the hypothetical protein Scp1=YOR367W from S. cerevisiae, the c-terminal the ORF encoded protein is highly repetitve. This repetitve part shows similarity to e. g. the mouse 'mena' protein Pubmed (8861907).; Title: similarity to hypothetical protein Scp1 -Saccharomyces cerevisiae
An01g08930	Title: weak similarity to hypothetical RNA binding protein BAA83714.1 - Homo sapiens
An01g08950	Remark: in C. albicans two very similar iron permeases has been discovered: CaFTR1 and CaFTR2. Mutants lacking CaFTR1 but not CaFTR2 exhibited a severe growth defect in iron-deficient medium and were unable to establish systemic infection in mice.; Title: strong similarity to high-affinity iron permease CaFTR2 - Candida albicans; See PMID 10807578
An01g08960	Function: the Fet1, CaFet1 gene products from S. cerevisiae and from C. albicans are iron transporter multicopper ferroxidases required for ferrous iron high affinity uptake (TC 9. A. 10).; Similarity: the ORF encoded protein shows also strong similarity to the S. cerevisae multicopper oxidase Fet3 (Pubmed 7836366;8293473).; Title: strong similarity to iron transport multicopper oxidase Fet3 - Candida albicans; See PMID 10517594
An01g08970	Title: weak similarity to tropomyosin I - Drosophila melanogaster; See PMID 3079761; See PMID 3038522
An01g08980	Similarity: the ORF encoded protein shows strongest similarity to the S. cerevisiae protein of unknown function Orm1 (YGR038w).; Title: strong similarity to membrane protein NHMP1 from patent WO9833817-A1 - Homo sapiens
An01g08990	Similarity: the similarities of the ORF encoded protein to the cnjB protein from T. thermophila and to other proteins are mainly based on repetitive structures.; Title: similarity to protein cnjB - Tetrahymena thermophila; See PMID 8233798
An01g09000	Similarity: the ORF encoded protein shows also similarities to some hypothetical phosphoglycolate phosphatases (EC 3. 1. 3. 18).; Title: strong similarity to hypothetical protein YOR131c - Saccharomyces cerevisiae
An01g09010	Title: weak similarity to gastric mucin clone PGM-2A - Sus scrofa; See PMID 7755593
An01g09020	Title: strong similarity to hypothetical protein ymaE - Bacillus subtilis
An01g09030	Remark: the ORF is N-terminal truncated due to border of contig.; Title: strong similarity to hypothetical protein CAD11387.1 - Neurospora crassa [truncated ORF]
An01g09040	Function: DEAD-box family RNA-helicases are involved in nuclear and mitochondrial splicing processes, RNA editing, rRNA processing, translation initiation, nuclear mRNA export, and mRNA degradation (see also the DEAD-box database at http://www. columbia. edu/~ej67/dbhome. htm).; Function: DEAD-box family RNA-helicases manipulate RNA in a manner that requires nucleoside triphosphates and have been shown to unwind purified RNA duplexes.; Function: at least one DEAD-box family protein,NPH-II from vaccinia virus, can effectively catalyze protein displacement from RNA and thereby participate in the structural reorganization of ribonucleoprotein assemblies.; Similarity: DEAD-box family RNA-helicases are highly conserved, howver only for few members of the family actual helicase activity has been proven e. g. not for MrDb.; Title: strong similarity to DEAD box protein MrDb -Homo sapiens; See PMID 10322435; See PMID 11141562; See PMID 8861962
An01g09050	Function: High levels of Ca 2+ added to the medium could reverse the effects of the spray and frost mutants in N. crassa (http://www. fgsc. net/asilo99/posterabs1. htm).; Function: N. crassa spray mutants initially grow as colonies that are flat on the surface, and then aerial mycelium fans upward (http://www. fgsc. net/compend/s. html).; Remark: data has not yet been published and is available via http://www. fgsc. net.; Title: similarity to calcium-related protein spray -Neurospora crassa
An01g09060	Function: human U1 snRNP protein C is a part of the splicosome involved in pre-mRNA processing.; Function: the splicosome forms, when a number of small nuclear ribonucleoprotein particles (snRNPs) bind sequentially to the pre-mRNA.; Title: strong similarity to U1 snRNP protein C -Homo sapiens; nucleus; See PMID 10322216
An01g09070	Remark: similarity to W96322 was retrieved using blastx against the GENESEQPROT protein database.; Title: weak similarity to inducible nitric oxide synthase from patent WO9906059-A2 - Homo sapiens
An01g09080	Similarity: similarity is between the central regions of the predicted A. niger protein and S. pombe TFIIH chain p47.; Title: weak similarity to transcription factor TFIIH chain p47 - Schizosaccharomyces pombe; See PMID 10077189
An01g09090	Title: strong similarity to hypothetical protein CAD11379.1 - Neurospora crassa
An01g09100	Function: A. oryzae ArpA null mutants showed poor growth and hyper-branched mycelia, as well as a nuclear distribution defect.; Function: Actin-related proteins (Arps) participate in a diverse array of cellular processes. They modulate assembly of conventional actin, contribute to microtubule-based motility catalyzed by dynein, and serve as integral components of large protein complexes required for gene expression.; Function: in A. oryzae overexpression of the ArpA gene causes a defect in nuclear migration into elongating hyphae of germlings.; Title: strong similarity to actin-related protein arpA - Aspergillus oryzae; cytoskeleton; See PMID 10611965; See PMID 10628858
An01g09110	Title: similarity to hypothetical protein encoded by B23L21.360 - Neurospora crassa
An01g09120	Title: strong similarity to hypothetical protein encoded by B23L21.370 - Neurospora crassa
An01g09130	Title: weak similarity to hypothetical photoreceptor membrane-associated protein trp - Drosophila melanogaster
An01g09160	Similarity: hZFH shows significant similarity to some proteins of the Snf2-like family, known to act as transcriptional regulators for multiple genes.; Title: similarity to hypothetical zinc-finger helicase hZFH - Homo sapiens
An01g09170	Title: similarity to hypothetical gene At2g19870 -Arabidopsis thaliana
An01g09180	Complex: ISW2p of S. cerevisiae forms a two-subunit complex with Itc1p.; Function: S. cerevisiae Isw2 complex represses transcription of early meiotic genes during mitotic growth in a parallel pathway to Rpd3-Sin3 histone deacetylase complex.; Function: the Isw2 complex functions at Ume6-dependent and -independent loci to create DNase I-inaccessible chromatin structure by regulating the positioning or placement of nucleosomes.; Function: the Isw2 complex functions mainly in repression of transcription in a parallel pathway with the Sin3-Rpd3 complex.; Localization: in vegetatively growing diploid cells,the Isw2 protein is cytoplasmic, whereas in cells entering sporulation Isw2p accumulates in the nucleus.; Phenotype: the isw2 homozygous deletant diploid strain was blocked in the G(1) phase of the cell cycle,unable to execute the premeiotic DNA replication and progress through the nuclear meiotic division cycle.; Remark: ISW2p/Itc1p interacts efficiently with both naked DNA and nucleosomal arrays in an ATP-independent manner.; Similarity: the predicted A. niger protein shows similarity to the ISW2 (Imitation Switch gene) protein of S. cerevisiae, which belongs to the superfamily II of DNA/RNA helicases (SNF2 family). the systematic name of ISW2 is YOR304w.; Title: strong similarity to Isw2 - Saccharomyces cerevisiae; See PMID 10090725; See PMID 10620773; See PMID 11081629; See PMID 11238944; See PMID 11533234
An01g09190	Title: weak similarity to hypothetical protein encoded by SPAC6B12.14c - Schizosaccharomyces pombe
An01g09210	Title: similarity to clathrin-associated adaptor complex assembly protein AP47 - Mus musculus; See PMID 10640811
An01g09220	Title: weak similarity to tyrosinase melC2 -Streptomyces lincolnensis
An01g09240	Remark: PTH11 is a pathogenicity gene predicted to encode a novel transmembrane protein. pth11 mutants are nonpathogenic and it is suggested that the protein is volved in host surface recognition by functioning as an upstream effector of appressorium differentiation.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g09250	Catalytic activity: 2-acetolactate + CO(2) <=> 2 pyruvate.; Pathway: synthesis of branched chain aminoacids.; Title: similarity to acetolactate synthase precursor ALS - Schizosaccharomyces pombe
An01g09260	Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O <=> an acid + NAD(P)H.; Title: strong similarity to aldehyde dehydrogenase (NADP+) - Homo sapiens
An01g09270	Catalytic activity: isocitrate <=> succinate + glyoxylate.; Title: strong similarity to isocitrate lyase acuD -Aspergillus nidulans
An01g09290	Title: strong similarity to neutral trehalase treB -Aspergillus nidulans
An01g09300	Remark: C-terminal half: high similaritiy to trk-transporters.; Remark: Mol. Microbiol. 37:671-679(2000).; Remark: a splice site was detected upstream of the START codon.; Title: similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis
An01g09310	Title: similarity to beta-ketoacyl reductase rhlG -Pseudomonas aeruginosa
An01g09320	Title: similarity to hypothetical protein YHL013c -Saccharomyces cerevisiae
An01g09330	Remark: Methyl chloride transferase catalyzes the synthesis of methyl chloride from S-adenosine-L-methionine and chloride ion.; Title: strong similarity to methyl chloride transferase BMCT - Batis maritima; See PMID 9789006
An01g09350	Title: similarity to hypothetical membrane protein YBR043c - Saccharomyces cerevisiae
An01g09380	Remark: protein possibly involved in attachment of the cellulosome to the cell surface.; Title: similarity to hypothetical S-layer protein -Clostridium thermocellum
An01g09390	Catalytic activity: 5-L-Glutamyl)-peptide + an Amino acid = Peptide +5-L-Glutamyl amino acid; Complex: the purified enzyme gamma-Glutamyltranspeptidase from Pseudomonas is composed of two nonidentical subunits.; Remark: processing of the precursor protein to its subunits is probably temperature-dependent.; Title: strong similarity to gamma-Glutamyltranspeptidase - Pseudomonas aeruginosa; See PMID 776530
An01g09400	Similarity: the ORF sequence shows some similarities to the A. oryzae EST SEQ ID NO:6333 rom patent WO200056762-A2.; Title: strong similarity to hypothetical protein CAD36997.1 - Neurospora crassa
An01g09410	Function: the zebrafish biklf gene encodes a novel Kruppel-like transcription factor.; Similarity: the predicted ORF shows similarity to some C2H2 zinc finger proteins.; Title: similarity to Kruppel-like transcription factor biklf - Danio rerio; See PMID 11025220
An01g09440	Similarity: shows only partial similarity to human COIL.; Title: weak similarity to coilin p80 COIL - Homo sapiens
An01g09450	Similarity: shows only partial similarity to several hypothetical proteins.; Title: similarity to hypothetical protein SMa0322 -Sinorhizobium meliloti
An01g09460	Function: WSC domain is a putative carbohydrate binding domain, the protein might be involved in carbohydrate utilization.; Remark: frameshift confirmed by cDNA comparison.; Remark: putative frameshift because of sequencing error.; Similarity: shows similarity to proteins with high content of repetitive sequences.; Title: similarity to glucoamylase III Wsc2 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 3138030
An01g09480	Function: mutants of T. aestivum show altered the phospholipid composition of wild type yeast, with the most marked effect being increased abundance of phosphatidylserine.; Localization: might be localized in the ER or might be a mitochondrial protein.; Title: strong similarity to phosphatidylserine synthase pS232 - Triticum aestivum
An01g09490	Function: GAR1 of S. cerevisiae is involved in 35S rRNA processing and required for pre-rRNA processing.; Function: GAR1 of S. cerevisiae is involved in cleavage of 33S precursor rRNA at A1 site to yield 32S rRNA and in cleavage of 32S precursor rRNA at A2 site to yield 20S and 27SA2 precursors.; Function: GAR1 of S. cerevisiae is involved in pre-rRNA pseudouridylation.; Similarity: strong similarity to S. pombe GAR1 and fruit fly GCR101 protein.; Title: strong similarity to nucleolar rRNA processing protein Gar1 - Saccharomyces cerevisiae; nucleus; See PMID 1531632; See PMID 8502556
An01g09500	Catalytic activity: ATP + L-threonine + tRNA(THR) = AMP + pyrophosphate + L-threonyl-tRNA.; Similarity: strong similarity to members of class II aminoacyl-tRNA synthetases.; Title: strong similarity to cytosolic threonine--tRNA ligase Ths1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2995918
An01g09510	Similarity: shows only partial similarity to sequence of DNA patent database.; Title: weak similarity to protein fragment SEQ ID NO:43781 from patent EP1033405-A2 - Arabidopsis thaliana
An01g09520	Function: MPKA of A. nidulans is involved in germination of conidial spores and polarized growth.; Function: MPKA of A. nidulans transfers phosphate from ATP to serine/threonine residues of the target protein.; Title: strong similarity to mitogen-activated protein kinase mPKA - Aspergillus nidulans; See PMID 10220889
An01g09530	Function: the C. nicotianae Crg1 is involved in cellular resistance to the perylenequinone toxin,cercosporin, that generates highly toxic singlet oxygen upon exposure to light.; Similarity: the A. niger protein, in contrast to CRG1 of C. nicotianae, contains a fungal-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to cercosporin resistance protein CRG1 - Cercospora nicotianae; See PMID 12604346
An01g09540	Title: strong similarity to hypothetical short chain alcohol dehydrogenase SPCC663.06c - Schizosaccharomyces pombe
An01g09550	Title: similarity to hypothetical dihydrolipoamide dehydrogenase Rv2713 - Mycobacterium tuberculosis
An01g09560	Function: YLL057c of S. cerevisiae plays a role in sulfonate catabolism.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536
An01g09570	Similarity: belongs to the major facilitator superfamily.; Title: strong similarity to hypothetical membrane protein YIL166c - Saccharomyces cerevisiae
An01g09580	Function: amyR of A. nidulans activates the expression of th gene encoding Taka-amylase A.; Induction: the expression of amyR of A. nidulans is under the control of the carbon catabolite repressor CREA.; Remark: an alternative name for amyR of A. nidulans is malA.; Title: strong similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; nucleus; See PMID 11318101
An01g09590	Complex: Kv beta 1 of R. norvegicus is an accessory protein of the voltage-gated potassium channel Kv1.; Function: Kv beta 1 of R. norvegicus modulates the activity of the pore-forming alpha subunit of the voltage-gated potassium channel Kv1.; Title: strong similarity to voltage-gated potassium channel beta subunit Kv beta 1 - Rattus norvegicus; See PMID 9687064; See PMID 8183366
An01g09600	Remark: the C-terminus contains a highly acidic domain.
An01g09610	Remark: due to the presence of an GST domain, the ORF show similarity to glutathione S-transferases.; Similarity: shows strong similarity to a 5'-EST of the A. niger cDNA clone an_2396.; Similarity: shows strong similarity to the N-terminal half of translation elongation factor eEF-1 gamma chain.; Title: strong similarity to gamma subunit of translation elongation factor eEF-1 - Homo sapiens
An01g09620	Catalytic activity: RH2OH + O2 = RHO + H2O2.; Function: fao1 of C. cloacae catalyzes the flavin-dependent omega-oxidation using molecular oxygen as acceptor, producing hydrogen peroxid.; Pathway: fao1 of C. cloacae functions in the utilization of alkanes and long-chain fatty acids as carbon source.; Title: strong similarity to long-chain-fatty-acid alcohol oxidase fao1 - Candida cloacae; endoplasmatic reticulum; See PMID 10660617
An01g09630	Title: strong similarity to hypothetical protein YDR132c - Saccharomyces cerevisiae
An01g09640	Function: NOL1/NOP1/sun proteins are thought to be involved in rRNA/tRNA processing.; Similarity: belongs to the NOL1/NOP1/sun family of nucleolar proteins.; Title: strong similarity to hypothetical nucleolar protein SPAC2C4.06c - Schizosaccharomyces pombe
An01g09650	Title: weak similarity to FYVE domain-containing dual specificity protein phosphatase FYVE-DSP1b - Homo sapiens
An01g09700	Title: similarity to EST an_1026 - Aspergillus niger
An01g09730	Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An01g09740	Catalytic activity: (S)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH.; Pathway: Beta-hydroxybutyryl-CoA dehydrogenase of C. acetobutylicum belongs to the butyrate/butanol-producing pathway.; Similarity: Beta-hydroxybutyryl-CoA dehydrogenase of C. acetobutylicum belongs to the 3-hydroxyacyl-CoA dehydrogenase family; Title: similarity to beta-hydroxybutyryl-CoA dehydrogenase hbd - Clostridium acetobutylicum; See PMID 8655474
An01g09750	Function: NADH-cytochrome b5 reductase is a component of a cytochrome b5-dependent electron transport system.; Function: NADH-cytochrome b5 reductase is involved in a variety of enzyme reactions these include fatty acyl coenzyme A desaturation or elongation, cholesterol biosynthesis, and certain cytochrome P-450-dependent oxidations.; Title: strong similarity to NADH-cytochrome b5 reductase - Mortierella alpina; See PMID 10473389
An01g09760	Function: cytochromes P450 are a group of heme-thiolate monooxygenases.; Similarity: human CYP4F2 belongs to the cytochrome P450 family.; Similarity: more than 250 N-terminal amino acids of the ORF are not included in the alignment with CYP4F2 of H. sapiens.; Title: strong similarity to cytochrome P450 4F2 CYP4F2 - Homo sapiens; See PMID 8026587; See PMID 10492403
An01g09770	Remark: the orf encoded protein shows homology to different types of protein kinases.; Title: similarity to mitogen-activated protein kinase ERK1 - Dictyostelium discoideum; See PMID 7935416
An01g09780	Catalytic activity: ldhA of E. coli catalyzes D-lactate + NAD(+) = pyruvate + NADH.; Function: ldhA of E. coli is a fermentative lactate dehydrogenase.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: ldhA of E. coli belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.; Title: strong similarity to D-lactate dehydrogenase ldhA - Escherichia coli [truncated ORF]; See PMID 9025293
An01g09790	Title: questionable ORF
An01g09800	Title: strong similarity to hypothetical protein encoded by ORF G4P06 - Aspergillus nidulans
An01g09810	Title: strong similarity to hypothetical alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase BH2688 - Bacillus halodurans
An01g09820	Catalytic activity: UDP glucose + 2 NAD+ + H2O = UDP glucuronate + 2 NADH.; Title: strong similarity to UDP-glucose dehydrogenase UDPGDH - Drosophila melanogaster; See PMID 9862465
An01g09830	Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Title: strong similarity to glutathione S-transferase Gtt1 - Saccharomyces cerevisiae; See PMID 9792709
An01g09850	Title: similarity to protein SEQ ID NO:2986 from patent WO200200677-A1 - Homo sapiens
An01g09860	Function: The hPrp18 protein of H. sapiens is required for the second step of mRNA splicing.; Title: strong similarity to pre-mRNA splicing factor hPrp18 - Homo sapiens; nucleus
An01g09870	Remark: Similarity to CaM II kinase of R. norvegicus is restricted to a single domain.; Similarity: the ORF is shorter than CaM II kinase of R. norvegicus (294 compared to 533 amino acids). Only 37 amino acids are included in the alignment between the two proteins.; Title: weak similarity to Ca2+/calmodulin-dependent protein kinase II delta chain - Rattus norvegicus
An01g09880	Title: similarity to hypothetical protein T41p -Homo sapiens
An01g09890	Function: ARL3 of S. cerevisiae is a non-essential protein that has a role in vesicular trafficking.; Remark: ARL3 of S. cerevisiae is also known as YPL051W.; Similarity: ARL3 of S. cerevisiae is a member of the highly conserved ADP-ribosylation factors (ARFs) family which are guanine nucleotide-binding proteins.; Title: strong similarity to ADP-ribosylation factor-like protein Arl3 - Saccharomyces cerevisiae; See PMID 9920936
An01g09900	Title: weak similarity to hypothetical protein Y2H9A.3 - Caenorhabditis elegans
An01g09910	Alternative name: GlcNAc-inositol phospholipid assembly protein, transcription factor SPT14.; Function: The S. cerevisiae SPT14 protein (SPT = Suppressor of Ty insertion mutations) was initially described as an activator of Ty transcription as well as regulator of several mating type genes including HIS4.; Remark: The S. cerevisiae SPT14 protein is similar to the H. sapiens PIG-A which is involved in transferring N-acetylglucosamine to lipopolysaccharides (biosynthesis of GPI anchors).; Title: strong similarity to GPI-anchor biosynthesis protein Pig-a - Saccharomyces cerevisiae
An01g09920	Remark: DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription,pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.; Title: strong similarity to hypothetical DEAD box ATP-dependent RNA helicase SPCC285.03 - Schizosaccharomyces pombe
An01g09930	Function: required for propionate catabolism.; Title: strong similarity to propionate catabolic protein PrpD - Salmonella typhimurium
An01g09940	Catalytic activity: Citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: conversion of oxaloacetate to citrate in the glyoxylate cycle.; Title: strong similarity to glyoxysomal citrate synthase - Cucurbita sp.; See PMID 7888626
An01g09950	Remark: The A. terreus cds is included in the lovastatin biosynthesis gene cluster.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994
An01g09960	Catalytic activity: Hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini.; Gene-ID: xlnD;xylD; Mapping: xlnD from A. niger is mapped to chromosome II (LG II); see list from DSM, EMBL Z84377.; Remark: The xlnD xylosidase exhibits high activity on the artificial substrate p-nitrophenyl beta-D-xylopyranoside (XylNp) and a sideactivity on p-nitrophenyl alpha-L-arabinofuranoside and p-nitrophenyl beta-D-glucopyranoside.; See PMID 9128738; See PMID 9546179
An01g09970	Title: weak similarity to Lactobacillus crispatus silent surface layer protein cbsB - Lactobacillus crispatus; See PMID 11053389
An01g09980	Title: strong similarity to hemolysin Asp-HS -Aspergillus fumigatus; See PMID 8086452; See PMID 8860955; See PMID 8913518; See PMID 16196; See PMID 778450
An01g10000	Title: strong similarity to ATP-binding cassette transporter abc1p - Schizosaccharomyces pombe; See PMID 9037770
An01g10010	Catalytic activity: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.; Function: The O-succinylhomoserine (thiol)-lyase met-7 chain of N. crassa is required to form O-succinylhomoserine (thiol)-lyase together with met-3 chain.; Remark: Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively.; Remark: In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.; Title: strong similarity to O-succinylhomoserine (thiol)-lyase met-7 chain - Neurospora crassa
An01g10030	Function: S. cerevisiae Syr2p is a sphingosine hydroxylase and provides resistance to the Pseudomonas syringae cyclic lipodepsipeptide syringomycin. Syr2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramid.; Remark: alternative gene names for the S. cerevisiae homolog SYR2 are SUR2 and YDR297w.; Title: strong similarity to syringomycin-resistance gene Syr2 - Saccharomyces cerevisiae
An01g10050	Remark: the immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) is produced by lymphocytes of atopic children.; Title: strong similarity to IgE-dependent histamine-releasing factor - Homo sapiens
An01g10060	Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An01g10070	Function: a S. cerevisiae mutant sec65-1 is conditionally defective in the insertion of integral membrane proteins into the ER.; Remark: the S. cerevisiae SEC65 gene encodes a 32 kDa subunit of yeast signal recognition particle (SRP).; Title: strong similarity to signal recognition particle chain Sec65 - Saccharomyces cerevisiae; See PMID 9723915
An01g10100	Similarity: strong similarity to superfamily of aminotransferases/transaminases.; Title: strong similarity to hypothetical aminotransferase SPBC1773.03c - Schizosaccharomyces pombe
An01g10130	Title: similarity to hypothetical protein encoded by An14g05700 - Aspergillus niger
An01g10140	Function: YSH1 is involved in cleavage of pre-mRNA during 3'-end formation in yeast.; Remark: BRR5 is an alternative name for YSH1.; Title: similarity to component of pre-mRNA polyadenylation factor PF I Ysh1 - Saccharomyces cerevisiae; nucleus; See PMID 9099738
An01g10150	Title: similarity to hypothetical protein CAD21098.1 - Neurospora crassa
An01g10170	Function: PK12 protein autophosphorylates in vitro on serine, threonine, and tyrosine residues, thereby making it a member of the dual-specificity protein kinases.; Similarity: protein kinase PK12 belong to the LAMMER family; Title: similarity to protein kinase PK12 - Nicotiana tabacum; See PMID 8989879
An01g10190	Function: mitochondrial tricarboxylate carrier shows citrate transport activity.; Remark: the ORF encoded protein also shows similarity to sideroflexin 1 from M. musculus. Disruption of this mitochondrial protein leads to pathologic intramitochondrial iron deposits in erythrocytes.; Title: similarity to mitochondrial tricarboxylate carrier - Rattus sp.; localisation:mitochondrion; See PMID 6617879; See PMID 8132491
An01g10200	Remark: most blastp matches are due to repetitive amino acids. In the other ones the match is restricted to the PDH Domain.; Title: weak similarity to hypothetical protein CG9007 - Drosophila melanogaster
An01g10240	Title: similarity to hypothetical protein Rv2802c -Mycobacterium tuberculosis
An01g10270	Title: similarity to hypothetical protein YOR243c -Saccharomyces cerevisiae
An01g10280	Title: weak similarity to transcriptional activator protein ACEII from patent WO9823642-A1 - Trichoderma reesei; nucleus
An01g10290	Remark: the ORF encoded protein shows similarity to several hypothetical and known (patented) oxidoreductases.; Title: similarity to protein fragment SEQ ID NO:11998 from patent EP1033405-A2 - Arabidopsis thaliana
An01g10310	Remark: blastp matches are due to repetitive amino acids.
An01g10320	Remark: blastp matches are unspecific.
An01g10340	Phenotype: yeast sur4 mutants have altered bud localization.; Phenotype: yeast sur4 mutants have altered phospholipid composition.; Remark: ELO3, SRE1 and VBM1 are alternative names for SUR4.; Title: similarity to hypothetical fatty acid elongation protein Sur4 - Saccharomyces cerevisiae; See PMID 9211877; See PMID 9832547
An01g10350	Catalytic activity: beta-galactosidases hydrolyse terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Function: A. niger lacA is involved in carbohydrate utilisation.; Title: strong similarity to secreted beta-galactosidase lacA - Aspergillus niger; See PMID 1368193
An01g10360	Function: TNA1 is necessary for nicotinic acid import into the cell.; Remark: YGR260w is the systematic name for TNA1 of S. cerevisiae.; Similarity: TNA1 belongs to the yeast Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An01g10370	Title: weak similarity to hypothetical protein D1044.3 - Caenorhabditis elegans
An01g10380	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An01g10450	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An01g10460	Title: similarity to hypothetical protein CAD21056.1 - Neurospora crassa
An01g10470	Title: similarity to hypothetical protein encoded by An01g09070 - Aspergillus niger
An01g10480	Title: strong similarity to FLO11 gene expression regulator At03 from patent WO200257456-A2 - Unclassified organism
An01g10490	Function: RIPA is a novel Ras-interacting protein from Dictyostelium, whose function is required for both chemotaxis and the synthesis and relay of the cyclic AMP (cAMP) chemoattractant signal.; Remark: similarity to RIPA is mainly due to Q-rich regions.; Title: similarity to Ras-interacting protein RIPA -Dictyostelium discoideum; See PMID 10473630
An01g10540	Function: the A. nidulans brlA gene is a primary regulator of development-specific gene expression during conidiation.; Remark: mutations in brlA, that disrupt either or both Cys2-His2 Zn(II) coordination sites, result in brlA alleles that fail to induce either the asexual reproductive pathway or the expression of development-specific genes.; Title: strong similarity to developmental regulatory protein brlA - Aspergillus nidulans; See PMID 2108321; See PMID 3293800; See PMID 9073485
An01g10550	Similarity: The transposase Minos-2 from Drosophila hydei is a member of the Tc1-like family of transposons.; Title: strong similarity to transposase Minos-2 -Drosophila hydei; See PMID 8197129; See PMID 1661410
An01g10570	Title: similarity to hypothetical protein EAA65998.1 - Aspergillus nidulans
An01g10580	Catalytic activity: Two-stage endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.; Title: strong similarity to ribonuclease T2 precursor rntB - Aspergillus oryzae; See PMID 1913876; See PMID 3169020
An01g10600	Title: strong similarity to hypothetical protein F2P05 - Aspergillus nidulans
An01g10610	Remark: D-arabinitol dehydrogenase from patent JP11332569-A is used as a clinical diagnosing agent for mycosis.; Title: similarity to D-arabinitol dehydrogenase from patent JP11332569-A - Bacillus sp.
An01g10640	Title: strong similarity to hypothetical exported protein YPO0987 - Yersinia pestis
An01g10650	Catalytic activity: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.; Induction: By N-carbamoyl-L-aspartate.; Pathway: URA4 catalyzes third step in pyrimidine biosynthesis pathway.; Similarity: URA4 belongs to the DHOase family.; Title: strong similarity to dihydroorotase Ura4 -Saccharomyces cerevisiae; See PMID 2897615
An01g10660	Title: similarity to hypothetical protein G4P04 -Aspergillus nidulans
An01g10680	Title: similarity to hypothetical developmental regulatory protein brlA - Aspergillus nidulans
An01g10690	Title: weak similarity to secreted protein SEQ ID NO: 305 from patent WO200142451-A2 - Homo sapiens
An01g10700	Title: strong similarity to hypothetical protein SPBC36B7.04 - Schizosaccharomyces pombe
An01g10710	Title: strong similarity to hypothetical protein DD57 - Mus musculus
An01g10720	Function: RPS31 is a structural protein of the small ribosomal (40S)-subunit.; Pathway: RPS31 is involved in protein biosynthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rps31 - Saccharomyces cerevisiae; cytoplasm; See PMID 9830035
An01g10730	Title: similarity to plasma membrane bound receptor from patent DE19627237-A1 - Sus scrofa
An01g10740	Title: strong similarity to hypothetical Ras-like GTP-binding protein RagC - Homo sapiens
An01g10750	Title: strong similarity to hypothetical acid phosphatase CAB58405.1 - Schizosaccharomyces pombe
An01g10760	Title: strong similarity to hypothetical protein YKR079c - Saccharomyces cerevisiae
An01g10770	Title: weak similarity to DNA-binding protein Mcm1 -Saccharomyces cerevisiae
An01g10790	Title: strong similarity to hypothetical conidiation-specific protein con-10 - Neurospora crassa
An01g10800	Function: ERG25 catalyses the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.; Localization: Immunofluorescence data suggest that ERG25 is present in the endoplasmic reticulum and plasma membrane.; Pathway: Ergosterol biosynthesis.; Similarity: ERG25 belongs to the sterol desaturase family.; Similarity: The amino acid sequence of ERG25 shows a C-terminal endoplasmic reticulum retrieval signal KKXX and three histidine-rich clusters found in eukaryotic membrane desaturases.; Title: similarity to methyl sterol oxidase Erg25 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8552601; See PMID 8663358
An01g10810	Remark: TRK1 is also involved in the control of the membrane potential.; Remark: The TRK1 potassium transporters of the soil yeast Schwanniomyces occidentalis is operating at low and medium K+ concentrations (< 1 mM); it functions at neutral and high pH and fails at low pH.; Title: strong similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis; See PMID 10931360
An01g10820	Title: strong similarity to hypothetical membrane protein YOR206w - Saccharomyces cerevisiae
An01g10830	Title: strong similarity to hypothetical protein YPL065w - Saccharomyces cerevisiae
An01g10840	Title: strong similarity to hypothetical membrane protein YBR271w - Saccharomyces cerevisiae
An01g10850	Function: S. cerevisiae Msp1 is involved in intramitochondrial sorting of proteins.; Localization: S. cerevisiae Msp1 is an integral membrane protein in the mitochondrial outer membrane.; Remark: alternate names for S. cerevisiae Msp1: Yta4 or YGR028W.; Similarity: S. cerevisiae Msp1 belongs to the AAA family of ATPases.; Title: similarity to membrane-spanning ATPase Msp1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7754704; See PMID 8226973
An01g10860	Title: similarity to hypothetical protein encoded by An04g08050 - Aspergillus niger
An01g10870	Function: C. albicans CHR1/S. cerevisiae Rok1 are involved in ribosome biogenesis. More specifically in a early step of the processing of the 35S rRNA precursor.; Remark: C. albicans CHR1 was cloned by functional complementation of the S. cerevisiae rok1 mutation. Literture for S. cerevisiae Rok1: Pubmed 9154839; 9848659; 9571634.; Similarity: the ORF encoded protein and the C. albicans CHR1 helicase are homologs of the well characterized Rok1 helicase from S. cerevisiae.; Title: strong similarity to DEAD box RNA helicase CHR1 - Candida albicans; nucleus; See PMID 10705369
An01g10880	Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Complex: the f-type ATPases have 2 components, Cf(1) - the catalytic core - and Cf(0) - the membrane proton channel. In S. cerevisiae, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta,epsilon, 4 (b), 5 (oscp), 6 (a), 8, 9 (c), d, e (tim11), f,g, h, i, j and k.; Function: the S. cerevisiae mitochondrial ATP synthase G chain (Atp20) is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial ATPase complex.; Remark: alternate names for S. cerevisiae Atp20: YPR020W or mitochondrial ATP synthase G chain.; Title: similarity to ATP synthase subunit g homolog Atp20 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9857174; See PMID 10336613
An01g10900	Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: similarity to hypothetical la costa protein lcs - Drosophila melanogaster
An01g10910	Catalytic activity: Catechol + O(2) <=> cis,cis-muconate.; Similarity: the ORF encoded protein is also similar to the sequence 379 from Patent WO0100842, but its function is not clearly enough decribed.; Title: similarity to catechol 1,2-dioxygenase alpha chain CatA - Pseudomonas sp.; See PMID 2295613; See PMID 7646060
An01g10920	Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Cofactor: Zinc.; Complex: Homotetramer.; Pathway: the rat Sorbitol dehydrogenase SDH is involved in the fructose and mannose metabolism.; Remark: Sorbitol dehydrogenase=L-iditol 2-dehydrogenase.; Title: strong similarity to sorbitol dehydrogenase SDH - Rattus norvegicus; See PMID 8223590; See PMID 8761460
An01g10930	Function: the sugar transferase from patent JP11009276-A preferably catalyses the glucose transfer of an alpha-1 right arrow 3 bond or the glucose transfer of an alpha-1 right arrow 3 and an alpha-1 right arrow 4 bond to a sugar receptor by reacting with a substrate selected from starch and its decomposition products.; Similarity: the ORF DNA sequence shows also strong similarity to the A. niger EST an_3550.; Title: strong similarity to enzyme with sugar transferase activity from patent JP11009276-A - Acremonium sp.
An01g10950	Title: similarity to protein involved in nonactin biosynthesis NonF - Streptomyces griseus; See PMID 10650222
An01g10960	Function: the LigI gene product from Sphingomonas paucimobilis catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylic acid.; Pathway: the LigI 2-pyrone-4, 6-dicarboxylic acid hydrolase is involved in lignin degradation.; Title: strong similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312; See PMID 11092855
An01g10970	Similarity: the N. crassa qa-y protein belongs to the maltose transport protein MAL61 superfamily.; Title: strong similarity to quinate transporter qa-y - Neurospora crassa; See PMID 1533844
An01g10980	Function: the N. crassa nit-4 protein pathway-specific regulatory gene of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: the nit-4 protein from N. crassa is a fungal Zn(2)-Cys(6) binuclear type transcription factor.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 7592372; See PMID 1840634
An01g10990	Catalytic activity: ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + L-threonyl-tRNA(Thr).; Remark: alternate name for S. cerevisiae Mst1: YKL194C.; Title: strong similarity to mitochondrial threonine--tRNA ligase Mst1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2999113
An01g11000	Remark: alternate name for S. cerevisiae Aga1: YNR044W.; Title: weak similarity to agglutinin core protein Aga1 - Saccharomyces cerevisiae
An01g11010	Remark: alternate name for S. cerevisiae Crh1: YGR189C.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; cell wall; See PMID 10757808
An01g11070	Pathway: the (+)-pinoresinol/(+)-lariciresinol reductase PLR from Forsythia x intermedia is involved in the biosynthesis of lignins.; Remark: the PLR enzyme from Forsythia x intermedia is identical to the protein described in patent WO9820113-A1.; Title: similarity to the +pinoresinol/+lariciresinol reductase PLR - Forsythia x intermedia; See PMID 8910615
An01g11080	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the Wis1 protein from S. pombe is a dosage-dependent regulator of mitosis with serine/threonine protein kinase activity. it may play a role in the integration of nutritional sensing with the control over entry into mitosis.; Remark: in S. pombe, the Wis1-Sty1 MAP (mitogen-activated protein) kinase signaling cascade is known to play a major role in cellular adaptation to adverse external stimuli, including osmotic stress,oxidative stress, nutrient deprivation, DNA-damaging agents, and heat stress.; Title: strong similarity to MAP kinase kinase wis1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 9693384; See PMID 1756736
An01g11090	Title: weak similarity to de novo DNA cytosine methyltransferase Dnmt3a from patent WO9967397-A1 - Mus sp.
An01g11100	Similarity: the ORF encoded protein shows strong similarity to the hypothetical protein SPAC5D6. 04 (S. pombe).; Title: strong similarity to hypothetical membrane protein YBR287w - Saccharomyces cerevisiae
An01g11120	Function: the S. cerevisiae Fet5 protein is a iron transport multicopper oxidase, which is required for ferrous iron high affinity uptake. It may be required to oxidize Fe(II) and release it from the transporter. It is an essential component of copper-dependent iron transport.; Remark: alternate name for S. cerevisiae Fet5: YFL041W.; Title: strong similarity to multicopper ferroxidase iron transport mediator Fet5 - Saccharomyces cerevisiae; See PMID 9413439
An01g11130	Catalytic activity: a phosphatidylcholine + H(2)O <=> 1,2-diacylglycerol+ choline phosphate.; Cofactor: Zinc.; Pathway: the non-hemolytic phospholipase C from B. pseudomallei is involved in phospholipid degradation.; Title: strong similarity to non-hemolytic phospholipase C - Burkholderia pseudomallei; See PMID 10523590
An01g11140	Function: the probable acetyl transferase ORF5 is one of six genes found to be responsible for IAA (indole-3-acetic) production in Azospirillum brasilense.; Title: similarity to acetyl transferase of an indole-3-acetic acid producing gene cluster ORF5 -Azospirillum brasilense; See PMID 1896020
An01g11150	Catalytic activity: ATP + choline <=> ADP + O-phosphocholine.; Function: the choline kinase Cki1 from S. cerevisiae is responsible for phosphatidylcholine synthesis via the CDP-choline pathway. It also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline.; Pathway: S. cerevisiae Cki1 is involved in the CDP-choline and CDP-ethanolamine dependent pathways of the phospholipid biosynthesis.; Remark: alternate name for S. cerevisiae Cki1: YLR133W.; Title: strong similarity to choline kinase Cki1 -Saccharomyces cerevisiae; See PMID 10092638; See PMID 2536698
An01g11160	Catalytic activity: ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Remark: the human ubiquitin carboxyl-terminal hydrolase BAP1 is also described in patent WO9805968-A1.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase BAP1 - Homo sapiens; See PMID 9528852
An01g11180	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2680607
An01g11190	Function: for Pth11 from M. grisea it is suggested that it functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Title: similarity to plasma membrane protein Pth11 -Magnaporthe grisea; plasma membrane; See PMID 10521529
An01g11200	Remark: SRPK family members may be uniquely regulated and targeted, thereby contributing to splicing regulation in different tissues, during development, or in response to signaling.; Remark: higher eukaryotes are showing similar genes but are approximately 100-150 amino acids longer.; Remark: reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells.; Title: strong similarity to serine kinase SRPK2 -Homo sapiens; See PMID 9472028
An01g11220	Title: weak similarity to hypothetical protein encoded by An07g02370 - Aspergillus niger
An01g11240	Remark: the ORF is short in length (71 amino acids).
An01g11250	Title: weak similarity to intestinal mucin MUC3 -Homo sapiens
An01g11260	Remark: STB5 encodes a C6 zinc cluster DNA-binding protein which interacts with the sin3 transcriptional repressor.; Title: similarity to regulator protein Stb5 -Saccharomyces cerevisiae; See PMID 9393435; See PMID 10961924
An01g11270	Remark: removes carboxyl groups from ring mounted carboxyls, particularly in the production of catechol.; Remark: similarity to A. niger 2,3-dihydroxybenzoic acid decarboxylase protein patent WO9909048-A1.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger
An01g11280	Catalytic activity: cyclohexanone + NADPH + O2 = 6-hexanolide + NADP+ + H2O.; Pathway: caprolactam degradation.; Remark: putative sequencing error at position 17435,generating a stop codon.; Remark: the activity of estf1 P. fluorescens increased from gamma-butyrolactone (18. 1 U/mg) to epsilon-caprolactone (21. 8 U/mg) to delta-valerolactone (36. 5 U/mg). The activities towards the aliphatic esters were significantly lower; the only exception was the activity toward ethyl caprylate, which was the preferred substrate.; Similarity: to cyclohexanone monooxygenase proteins in different organisms.; Title: similarity to lactone-specific esterase estf1 - Pseudomonas fluorescens [putative sequencing error]; putative sequencing error; See PMID 9925571
An01g11290	Remark: CFP encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting cercosporin, thus maintaining low cellular concentrations of the toxin.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Similarity: to multidrug resistance transporter proteins of the major facilitator superfamily.; Title: strong similarity to cercosporin transporter CFP - Cercospora kikuchii; See PMID 10517030
An01g11310	Similarity: the ORF shows similarity to several transcription regulators.; Title: weak similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194
An01g11320	Catalytic activity: L-tryptophan = tryptamine + CO2.; Pathway: histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism; alkaloid biosynthesis I.; Remark: DDC3 is used to increase the production of polypeptides by recombinant host filamentous fungal cells.; Remark: similarity to DDC3 (dopa decarboxylase 3) from Aspergillus oryzae patent WO9960136-A1.; Title: similarity to dopa decarboxylase 3 DDC3 from patent WO9960136-A1 - Aspergillus oryzae
An01g11330	Title: strong similarity to hypothetical protein CAD70322.1 - Neurospora crassa
An01g11340	Catalytic activity: release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; Remark: deletion of the yeast MAP1 gene is not lethal, suggesting that alternative NH2-terminal processing pathway(s) exist for cleaving methionine from nascent polypeptide chains in eukaryotic cells.; Similarity: belongs to the Escherichia coli methionyl aminopeptidase family.; Title: strong similarity to methionyl aminopeptidase Map1 - Saccharomyces cerevisiae; See PMID 1569059
An01g11360	Catalytic activity: release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; Remark: lower and higher eukaryotes, as well as bacteria, share a similar N-terminal protein processing machinery, indicating universality of this system.; Remark: the N-terminal protein processing pathway is an essential mechanism found in all organisms.; Remark: the trembl:AF250964_1 is putative the same as pir:T00698 exept the different 9 amino acids before the start methionine.; Similarity: to human methionyl aminopeptidase.; Title: strong similarity to methionine aminopeptidase-like protein F6E13.31 - Arabidopsis thaliana; See PMID 11060042
An01g11370	Remark: genetic analysis and GFP fusions show that the NLS of a Zn-binuclear cluster transcriptional activator of Aspergillus nidulans (PrnA) is tripartite.; Remark: the prnA gene A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360; See PMID 10788322
An01g11380	Title: strong similarity to sequence 1 from patent EP0845532 - Pseudomonas sp.
An01g11390	Remark: probable nadh-dependent flavin oxidoreductase.; Title: strong similarity to sequence 385 from patent WO0100842 - Corynebacterium glutamicum
An01g11400	Remark: only a small domain is homolog to many different proteins.; Title: weak similarity to hypothetical protein encoded by An02g00880 - Aspergillus niger
An01g11410	Title: strong similarity to hypothetical protein BAB49374.1 - Mesorhizobium loti
An01g11430	Remark: weak similarity to cell surface proteins with repetetive sequences.; Title: weak similarity to S-layer protein -Clostridium thermocellum
An01g11440	Catalytic activity: UDPglucose = UDPgalactose.; Pathway: galactose metabolism; nucleotide sugars metabolism.; Remark: null mutant of gal10 S. cerevisiae is viable and cannot utilize galactose.; Similarity: belongs to the UDPglucose 4-epimerase family; Title: similarity to UDPglucose 4-epimerase Gal10 -Saccharomyces cerevisiae; See PMID 6092912; See PMID 6715281
An01g11450	Remark: ophD encodes a permease for phthalate transport.; Similarity: to putative allantoate transporter proteins from different organisms.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; See PMID 10498738
An01g11470	Title: similarity to hypothetical protein encoded by An08g09690 - Aspergillus niger
An01g11480	Remark: RT-PCR experiments confirm that ox1 is expressed under conditions of peptide alkaloid biosynthesis.; Remark: the ox1 is 100 aa shorter in the N-terminal region, but all other similaritys are shown to oxidoreductases with different substrate specificity.; Title: strong similarity to oxidoreductase ox1 -Claviceps purpurea; See PMID 10071219
An01g11500	Similarity: the ORF shows weak similarity to the hypothetical protein C33D9. 8 of C. elegans.; Title: weak similarity to hypothetical protein encoded by An16g04050 - Aspergillus niger
An01g11510	Catalytic activity: Hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; Pathway: glycosaminoglycan degradation.; Remark: it is a periplasmic enzyme and acts as homodimer.; Remark: mucin desulfation is believed to be a rate-limiting step in mucin degradation by colon bacteria.; Title: strong similarity to mucin-desulfating sulfatase MdsA - Prevotella sp.; See PMID 10809675; See PMID 10981693
An01g11520	Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Gene-ID: pgaI; Pathway: pentose and glucuronate interconversions; starch and sucrose metabolism.; Remark: strong similarity to prepro-polygalacturonase I patent EP421919-A from Aspergillus niger.; See PMID 10945680; See PMID 1934135
An01g11530	Remark: AWI 31 was specifically induced by wounding.; Remark: not regulated by other environmental stresses such as drought, high salt, low temperature, or a DPE herbicide treatment.; Title: similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278
An01g11540	Remark: expression of FLU1 in YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; See PMID 11181345
An01g11550	Title: strong similarity to hypothetical protein CAD21353.1 - Neurospora crassa
An01g11560	Catalytic activity: Digallate + H2O = 2 Gallate.; Remark: also hydrolyses ester links in other tannins.; Remark: similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms--from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769
An01g11570	Similarity: the ORF shows weak similarity to the DNA binding protein Ncp1 of Ustilago maydis.; Title: similarity to hypothetical protein encoded by An01g11580 - Aspergillus niger
An01g11580	Title: similarity to hypothetical protein encoded by An01g11570 - Aspergillus niger
An01g11590	Title: similarity to hypothetical protein encoded by An01g01670 - Aspergillus niger
An01g11600	Remark: DAL5 encodes a component of the allantoate transport system.; Remark: its relatively high basal level of expression did not increase further upon addition of allantoin pathway intermediates.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3275614; See PMID 3301804
An01g11610	Remark: the Pyrococcus horikoshii enzyme has the following properties: an aminoacylase activity and a carboxypeptidase activity.; Remark: the protein shows also similarity to Pyrococcus horikoshii enzyme, patent JP10210976-A.; Title: similarity to indole-3-acetyl-L-aspartic acid hydrolase IAA-asp - Enterobacter agglomerans; See PMID 9747708; See PMID 10651904
An01g11620	Remark: the expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer.; Remark: the protein belongs to a fungal regulatory familiy containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; See PMID 9701810; See PMID 10975256
An01g11630	Function: Sss1 from S. cerevisiae is required for continued translocation of secretory precursor proteins through the ER membrane.; Function: overexpressed SSS1 from S. cerevisiae restores translocation in the sec61 mutant.; Localization: Sss1 from S. cerevisiae is firmly bound to the ER membrane and exposes its amino-terminal half on the cytosolic side.; Remark: Sss1 from S. cerevisiae interacts directly with Sec61, a 10-transmembrane-domain membrane protein of the heterotrimeric Sec61p complex.; Remark: the evolutionarily conserved Sec61 protein complex mediates the translocation of secretory proteins into the endoplasmic reticulum.; Title: strong similarity to translocation complex component Sss1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7961662; See PMID 8223425; See PMID 9303299
An01g11640	Remark: MEP2 is an ammonium sensor, generating a signal to regulate filamentous growth in response to ammonium starvation.; Remark: MEP2, a high affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium limitation.; Title: strong similarity to high affinity low capacity ammonia permease Mep2 - Saccharomyces cerevisiae; See PMID 9234685; See PMID 9482721
An01g11650	Catalytic activity: 10-Formyltetrahydrofolate + H2O = Formate + Tetrahydrofolate.; Pathway: glyoxylate and dicarboxylate metabolism; one carbon pool by folate.; Remark: also strong similarity to formate transport associated protein, PurU - Bacillus subtilis from patent WO9927107-A2.; Remark: it appears that PurU provides the major source of formate for the purT-dependent synthesis of FGAR.; Title: strong similarity to formyltetrahydrofolate deformylase purU - Corynebacterium sp.; See PMID 7543100
An01g11660	Catalytic activity: hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.; Gene-ID: cbhB; Mapping: cbhB from A. niger is mapped to chromosome II; see list from DSM, EMBL AF156269.; Pathway: starch and sucrose metabolism.; Remark: northern blot analysis showed that the transcription of the cbhA and cbhB genes is induced by D-xylose but not by sophorose and, in addition, requires the xylanolytic transcriptional activator XlnR.; Remark: patent cbhB WO9906574-A1.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; See PMID 10508057
An01g11670	Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism; Remark: also hydrolyse 1,4-linkages in beta-D-glucans also containing 1,3-linkages.; Title: strong similarity to endo-beta-1,4-glucanase A eglA - Aspergillus nidulans; See PMID 10386374
An01g11680	Catalytic activity: 3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-Carboxy-cis,cis-muconate.; Pathway: phenylalanine metabolism; Remark: the stereochemical and regiochemical course of the reaction is (i) opposite that of CMLE from Pseudomonas putida (EC 5. 5. 1. 2) and (ii) identical to that of cis,cis-muconate lactonizing enzyme (MLE; EC 5. 5. 1. 1) from P. putida.; Title: strong similarity to carboxy-cis,cis-muconate cyclase CMLE - Neurospora crassa; See PMID 4448182; See PMID 4448183; See PMID 8132467
An01g11690	Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g11700	Title: weak similarity to BPP-CNP precursor homolog - Agkistrodon blomhoffi
An01g11710	Remark: the similarity partially located in the middle of the protein.; Title: weak similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; See PMID 8594329
An01g11720	Title: strong similarity to hypothetical protein YPL206c - Saccharomyces cerevisiae
An01g11740	Alternative name: Microsomal dipeptidase. Renal dipeptidase. Dehydropeptidase I. DPH I.; Cofactor: zinc; Function: hydrolysis of dipeptides. Hydrophobic dipeptides are cleaved preferentially, including prolyl amino acids.; Localization: membrane bound, with broad specificity.; Remark: inhibited by bestatin and cilastatin.; Similarity: belongs to peptidase family M19.; Title: strong similarity to hypothetical membrane dipeptidase - Schizosaccharomyces pombe
An01g11750	Similarity: the ORF shows also weak similarity to the protein-tyrosine kinase homolog btl of D. melanogaster and to tyrosine-kinases of other species.; Title: weak similarity to polypeptide SEQ ID NO:41298 from patent WO200171042-A2 - Drosophila melanogaster
An01g11760	Title: similarity to polypeptide SEQ ID NO:6405 from patent WO200171042-A2 - Drosophila melanogaster
An01g11770	Remark: N-methyl peptide synthetase.; Remark: probable a short peptid synthetase.; Title: similarity to peptide synthase enniatin synthase esyn1 - Fusarium scirpi; See PMID 8483420; See PMID 11085259; See PMID 7601090
An01g11780	Similarity: TO PROTEINS WITH A CORE MUTT DOMAIN.; Title: weak similarity to dATP pyrophosphohydrolase NMB0642 - Neisseria meningitidis
An01g11790	Similarity: the ORF shows similarity to several hypothetical peptide synthetases.; Title: similarity to hypothetical acetate--CoA ligase involved in polyketide synthesis pksJ - Bacillus subtilis; See PMID 9384377; See PMID 8344529
An01g11800	Catalytic activity: Phenol + NADPH + O(2) <=> catechol + NADP(+) + H(2)O; Title: strong similarity to phenol 2-monooxygenase -Trichosporon beigelii
An01g11810	Catalytic activity: ppe1 of S. pombe catalyses the reaction a phosphoprotein + H(2)O <=> a protein + phosphate.; Remark: a gene disruption (designated delta ppe1) causes cold-sensitive lethality and short, pear-shaped cells.; Similarity: the predicted A. niger protein shows strong similarity to cell shape control protein phosphatase ppe1 from S. pombe and other serine/threonine protein phosphatases.; Title: strong similarity to cell shape control protein phosphatase ppe1p - Schizosaccharomyces pombe; See PMID 8387356
An01g11820	Title: similarity to hypothetical nucleolar phosphoprotein - Neurospora crassa
An01g11830	Title: weak similarity to protein YIL159w -Saccharomyces cerevisiae
An01g11840	Title: strong similarity to hypothetical protein encoded by An05g02120 - Aspergillus niger
An01g11860	Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; See PMID 9207794; See PMID 2017167
An01g11880	Function: ordA of A. parasiticus is involved in the conversion of O-methylsterigmatocystin (OMST) to aflatoxin B1.; Remark: a putative frameshift results in an premature STOP codon.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the ORF shows strong similarity to several cytochrome P450-type monooxygenases from different species.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus [putative frameshift]; putative frameshift
An01g11900	Title: weak similarity to protein fragment SEQ ID NO:47715 from patent EP1033405-A2 - Arabidopsis thaliana
An01g11910	Remark: Fission yeast cut17 is required for chromosome segregasion.; Remark: group of cut proteins consists of mutants in which a portion of the nuclear chromatin is stretched by the elongated spindle but the entire nucleus is not separated.; Remark: similarity to Inhibitor of Apoptosis domain; Title: similarity to protein cut17p -Schizosaccharomyces pombe; See PMID 8395535; See PMID 10910336
An01g11920	Title: similarity to hypothetical protein SPBC1A4.06c - Schizosaccharomyces pombe
An01g11930	Catalytic activity: L-histidinol-phosphate + 2-oxoglutarate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.; Function: histidinol-phosphate aminotransferase.; Pathway: eighth step in histidine biosynthetic pathway.; Remark: responsive to control of general amino acid biosynthesis.; Title: strong similarity to histidinol-phosphate transaminase his3p - Schizosaccharomyces pombe
An01g11940	Similarity: the ORF shows weak similarity to chitinase chiA of A. nidulans.; Title: similarity to putative integral membrane protein CAF32121.1/AfA33H4.055c - Aspergillus fumigatus
An01g11950	Catalytic activity: Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1); Remark: DNA-directed RNA polymerase I, II, III 25 KD subunit.; Title: strong similarity to 25 kD subunit of DNA-directed RNA polymerase I,II,III Rpb5 - Saccharomyces cerevisiae; nucleus; See PMID 10841537
An01g11960	Complex: Bfr1 also associates with yeast polyribosomes and mRNP complexes.; Complex: Bfr1 interacts with Bbp1, a component of the spindle pole body.; Remark: Bfr1 protein from S. cerevisiae is a multicopy suppressor of brefeldin A-induced lethality. Bfr1, in addition, partially suppresses the growth and secretion defects of the ER-to-Golgi secretion mutant sec17.; Similarity: the predicted A. niger protein shows strong similarity to Bfr1 protein from S. cerevisiae. stronger similarity is found with the hypothetical protein SPAC458. 02c from S. pombe.; Title: similarity to brefeldin A resistance protein Bfr1 - Saccharomyces cerevisiae; See PMID 11410665; See PMID 8070655
An01g11970	Function: mixed-linked glucanases are extracellular enzymes able to hydrolyze beta 1,3-1,4-glucans.; Title: strong similarity to mixed-linked glucanase MLG1 - Cochliobolus carbonum; See PMID 9464371
An01g11990	Title: strong similarity to hypothetical protein CAF32129.1 - Aspergillus fumigatus
An01g12000	Function: dsk1 of S. pombe is a protein kinase, that auto-phosphorylates as well as phosphorylates e. g. myelin basic protein (MBP).; Induction: mitotically arrested S. pombe cells have a several-fold higher kinase activity of dsk1 than that from wild type.; Phenotype: high dosage of dsk1+ strongly delays the G2/M progression of S. pombe cells.; Title: similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317
An01g12010	Title: weak similarity to phosphoprotein phosphatase PPT - Rattus norvegicus; See PMID 8077208
An01g12020	Similarity: the ORF shows weak similarity to putative bi-functional transferase/deacetylase of S. coelicolor.; Title: strong similarity to hypothetical protein encoded by An04g09400 - Aspergillus niger
An01g12030	Title: strong similarity to hypothetical protein encoded by An01g12040 - Aspergillus niger
An01g12040	Similarity: shows similarity to several polyketide synthases and fatty acid synthases; the similarity is restricted to the short-chain alcohol dehydrogenase homology and acyl carrier protein homology domains of polyketide synthases and to the beta-ketoacyl reductase and acyl carrier domains of fatty acid synthases.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis; See PMID 10413619
An01g12050	Pathway: trichothecene synthesis.; Remark: Regulation of TRI3 transcription in liquid cultures appeared identical to that of other trichothecene pathway genes.; Remark: TRI3 is an acetyltransferase that converts 15-decalonectrin to calonectrin.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to 15-decalonectrin 15-O-acetyltransferase TRI3 - Fusarium sporotrichioides; See PMID 8593041
An01g12060	Function: Pwp2p exists in a proteinaceous complex,possibly associated with the cytoskeleton, where it functions in control of cell growth and separation.; Function: it is required for bud-site selection and cell separation.; Localization: HA-Pwp2p of S. cerevisiae was clustered at multiple points in the cytoplasm, probably associates with the cytoskeleton.; Title: similarity to WD-repeat protein Pwp2 -Saccharomyces cerevisiae; See PMID 8804409
An01g12090	Catalytic activity: Nitrile + H2O = a Carboxylate + NH3.; Remark: the Klebsiella ozaenae nitrilase BXN converts the herbicide bromoxynil (3,5-dibromo-4-hydroxybenzonitrile) to 3,5-dibromo-4-hydroxybenzoic acid.; Title: strong similarity to nitrilase BXN -Klebsiella ozaenae
An01g12100	Remark: The gene is required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter.; Remark: This protein is similar to vanB, but seems 300 aa to long.; Remark: VanA and VanB form an oxygenative demethylase that converts vanillate to protocatechuate in microorganisms.; Title: similarity to vanillate demethylase vanB -Acinetobacter sp.; cytoplasm; See PMID 10348863; See PMID 10671462
An01g12110	Title: similarity to hypothetical protein YLL056c -Saccharomyces cerevisiae
An01g12120	Title: weak similarity to transcription regulator Rgt - Saccharomyces cerevisiae
An01g12130	Catalytic activity: plant enzyme with EC number EC 2. 3. 1. 144 catalyses benzoyl-CoA + anthranilate <=> CoA + N-benzoylanthranilate.; Remark: catalyzes the synthesis of anthranilate (vitamin L1) involved in plant phytoalexin biosynthesis.; Title: similarity to anthranilate N-benzoyltransferase - Dianthus caryophyllus; See PMID 9426598
An01g12150	Gene-ID: lacA+; See PMID 1368193
An01g12170	Catalytic activity: Alcohol + NAD+ = Aldehyde or Ketone + NADH; Pathway: Bile acid biosynthesis; Pathway: Fatty acid metabolism; Pathway: Glycerolipid metabolism; Pathway: Glycolysis / Gluconeogenesis; Pathway: Tyrosine metabolism; Title: strong similarity to alcohol dehydrogenase alcB - Aspergillus nidulans; See PMID 8821658; See PMID 10938850
An01g12180	Catalytic activity: S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine + tRNA containing 5-methylcytosine.; Remark: similarity to nucleolar Nop2p.; Remark: similarity to proteins involved in rRNA processing.; Remark: weak similarity to human proliferation associated nucleolar antigen P120.; Title: strong similarity to tRNA (cytosine-5-)-methyltransferase Ncl1 - Saccharomyces cerevisiae; nucleus; See PMID 9767141; See PMID 10445884
An01g12190	Function: MCT3 of H. sapiens is a proton-linked monocarboxylate transporter, that was shown to facilitate cellular import of lactate and pyruvate.; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 10510291
An01g12200	Title: similarity to hypothetical protein F10B6.29 -Arabidopsis thaliana
An01g12210	Function: in Neurospora crassa the beta chain of the mitochondrial processing peptidase and the core I protein of ubiquinol--cytochrome-c reductase are identical.; Function: the protein is bifunctional and participates both in protein processing and electron transport.; Title: strong similarity to core protein I of ubiquinol--cytochrome-c reductase beta-MPP - Neurospora crassa; localisation:mitochondrion
An01g12220	Pathway: galactose metabolism.; Similarity: shows much higher similarity to yet probable fungal UDPglucose 4-epimerases.; Title: similarity to protein SEQ ID NO:52 from patent WO200111033-A2 - Haemophilus influenzae
An01g12230	Function: it is associated with snoRNA and required for 35S rRNA processing and methylation.; Function: it is involved in cleavage of 33S precursor rRNA at A1 site to yield 32S rRNA.; Function: it is involved in cleavage of 35S precursor rRNA at A0 site to yield 33S rRNA.; Function: protein of S. cerevisiae is involved in cleavage of 32S precursor rRNA at A2 site to yield 20S and 27SA2 precursors.; Title: strong similarity to nucleolar protein Nop1 -Saccharomyces cerevisiae; nucleus
An01g12240	Title: strong similarity to hypothetical protein CAC28784.2 - Neurospora crassa
An01g12250	Remark: ORF might be questionable at the carboxyterminus.
An01g12260	Similarity: blast hits result from repetitive sequences.
An01g12270	Similarity: shows only partial similarity to fungal hypothetical protein and is probably not an integral membrane protein.; Title: similarity to hypothetical membrane protein YPL277c - Saccharomyces cerevisiae
An01g12290	Similarity: shows similarity to homeodomain repressor proteins in the family of Drosophila Cut.; Title: similarity to CCAAT displacement protein CASP - Homo sapiens; See PMID 9332351
An01g12300	Function: TRAP-1 can distinguish activated forms of the receptor from wild-type receptor in the absence of TGFbeta and may potentially have a functional role in TGFbeta signaling.; Similarity: shows only partial similarity at the carboxyterminus.; Title: similarity to TGF beta receptor associated protein-1 TRAP-1 - Homo sapiens
An01g12310	Catalytic activity: hydroxyquinol 1,2-dioxygenase of A. sp. was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol.; Cofactor: iron.; Remark: when hydroxyquinol was used as a substrate,the purified enzyme of A. sp. showed 6. 8-fold activity of that for catechol.; Title: similarity to hydroxyquinol 1,2-dioxygenase BAA82713.1 - Arthrobacter sp.; See PMID 10380628
An01g12320	Function: might be involved in transcriptional regulation.; Similarity: contains a fungal Zn(2)-Cys(6) binuclear cluster and shows weak similarity to proteins containing the same domain.; Title: strong similarity to possible transcription factor CAF32142.1 - Aspergillus fumigatus
An01g12330	Complex: purified human LSm proteins form a heteromer that is stable even in the absence of RNA and exhibits a doughnut shape under the electron microscope,with striking similarity to the Sm core RNP structure.; Function: the purified LSm heteromer binds specifically to U6 snRNA and it facilitates the formation of U4/U6 RNA duplices in vitro, suggesting that it may play a role in U4/U6 snRNP formation.; Title: similarity to U6 snRNA-associated Sm-like protein LSm7 - Homo sapiens; nucleus; See PMID 10523320
An01g12340	Remark: truncated ORF due to contig border.
An01g12350	Remark: truncated ORF due to contig border.; Similarity: shows weak similarity to proteins containing Leucine Rich Repeats.; Title: similarity to hypothetical protein encoded by An15g02640 - Aspergillus niger [truncated ORF]
An01g12360	Function: pan3 of S. cerevisiae is involved in cell wall biogenesis and architecture.; Similarity: similarity is restricted to carboxyterminus.; Title: similarity to component of the Pab1p-dependent poly(A) ribonuclease Pan3 - Saccharomyces cerevisiae; See PMID 8816488; See PMID 9774670
An01g12370	Title: similarity to hypothetical protein SPCC285.11 - Schizosaccharomyces pombe
An01g12380	Function: multidrug resistance.; Similarity: shows strong similarity to several fungal ABC-transporter.; Title: strong similarity to ATP-binding cassette transporter PMR1 - Penicillium digitatum; plasma membrane; See PMID 9758830
An01g12390	Title: similarity to repressed by TUP1 protein 2 RBT2 - Candida albicans; See PMID 10790384
An01g12400	Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840
An01g12410	Similarity: to some transcription factors.; Title: similarity to regulator protein qutA -Aspergillus nidulans
An01g12420	Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L17 - Rattus norvegicus; cytoplasm; See PMID 2211664
An01g12430	Title: strong similarity to hypothetical protein CAF32157.1 - Neurospora crassa
An01g12440	Remark: similarities correspond to multiple S-repeats.; Title: similarity to hypothetical protein BAA13766.1 - Schizosaccharomyces pombe
An01g12450	Title: strong similarity to hypothetical glucan beta-1,3 exoglucanase exgS - Aspergillus phoenicis
An01g12460	Title: similarity to hypothetical valine--pyruvate transaminase DR1030 - Deinococcus radiodurans
An01g12470	Title: similarity to hypothetical Atu related protein - Neurospora crassa
An01g12480	Title: similarity to hypothetical ankyrin-like cytoskeletal-structural protein - Drosophila melanogaster
An01g12490	Similarity: the ORF shows similarity to NADH dehydrogenase (complex I) as well as others not involved in respiration (1. 6. 99. 3).; Title: similarity to 64 kD NADH dehydrogenase ndh64 - Neurospora crassa; See PMID 10482790
An01g12500	Catalytic activity: A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).; Title: strong similarity to acetamidase amdS -Aspergillus oryzae
An01g12520	Title: strong similarity to beta-ketoacyl reductase rhlG - Pseudomonas aeruginosa
An01g12530	Catalytic activity: O2. - + O2. - + 2 H+ = O2 + H2O2.; Title: strong similarity to manganese superoxide dismutase - Penicillium chrysogenum
An01g12540	Title: weak similarity to hypothetical protein YPL158c - Saccharomyces cerevisiae
An01g12550	Catalytic activity: hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.; Pathway: glycoprotein biosynthesis.; Remark: A. saitoi msdS enzyme has activity with methyl-2-O-alpha-d-mannopyranosyl alpha-D-mannopyranoside at pH 5. 0, while no activity was determined with methyl-3-O-alpha-D-mannopyranosyl alpha-D-mannopyranoside or methyl-6-O-alpha-D-mannopyranosyl alpha-D-mannopyranoside. The substrate specificity of the enzyme was analysed by using pyridylaminated (PA)-oligomannose-type sugar chains, Man9-6(GlcNAc)2-PA (Man is mannose; GlcNAc is N-acetylglucosamine). The enzyme hydrolysed Man8GlcNAc2-PA (type 'M8A') fastest, and 'M6C' Manalpha1-3[Manalpha1-2Manalpha1-3(Manalpha1-6) Manalpha1-6]Manbeta1-4GlcNAcbeta1-4GlcNAc-PA slowest, among the PA-sugar chains.; Remark: Aspergillus saitoi is a synonym for Aspergillus phoenicis.; Remark: strong similarity to A. niger ESTs: an_3639,an_2055, an_2131, an_2995.; Similarity: belongs to the glycosyl hydrolase family 47.; Title: strong similarity to mannosyl-oligosaccharide 1,2-alpha-mannosidase msdS - Aspergillus saitoi; See PMID 8519794; See PMID 10215597
An01g12570	Catalytic activity: L-histidinol + 2 NAD+ = L-histidine + 2 NADH.; Pathway: histidine metabolism.; Remark: his-3 of N. crassa is a mutifunctional enzyme with the following enzymatic activities: phosphoribosyl-AMP cyclohydrolase (EC 3. 5. 4. 19) / phosphoribosyl-ATP pyrophosphatase (EC 3. 6. 1. 31) / histidinol dehydrogenase (EC 1. 1. 1. 23).; Similarity: belongs to the histidinol dehydrogenases.; Title: strong similarity to histidinol dehydrogenase his-3 - Neurospora crassa; See PMID 2529437; See PMID 2530448; See PMID 3005109
An01g12580	Title: similarity to protein fragment SEQ ID NO:21284 from patent EP1033405-A2 - Arabidopsis thaliana
An01g12590	Similarity: shows also similarity to EST l3g02a1. r1 from Aspergillus nidulans.; Title: similarity to hypothetical protein 5C2.160 -Neurospora crassa
An01g12600	Remark: TAF17 is broadly, but not universally,required for transcription in yeast, TAF17 depletion and TAF130 depletion each disrupt TFIID integrity yet cause different transcriptional consequences, suggesting that the widespread influence of TAF17 might not be due solely to its function in TFIID.; Remark: alternative name is YMR236w.; Remark: the homologues of this ORF are 50 % shorter.; Similarity: to human transcription factor TFIID.; Title: strong similarity to subunit of transcription initiation factor TFIID Taf17 - Saccharomyces cerevisiae; nucleus; See PMID 8962109; See PMID 10747053
An01g12610	Remark: disruption of the yeast genomic SMP2 gene resulted in a respiration-deficient phenotype, although the cells retained mitochondrial DNA, and showed increased stability of pSR1 like the original smp2 mutant. The function of the Smp2 protein in plasmid maintenance is independent of respiration.; Title: strong similarity to plasmid maintenance,respiration and cell proliferation protein Smp2 -Saccharomyces cerevisiae; See PMID 8437575
An01g12620	Title: similarity to hypothetical protein 5C2.150 -Neurospora crassa
An01g12630	Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 61882 patent EP1033405-A2.; Title: strong similarity to hypothetical protein BAB27240.1 - Mus musculus
An01g12640	Title: strong similarity to hypothetical protein EAA65635.1 - Aspergillus nidulans
An01g12680	Title: weak similarity to DNA-binding protein 5E5 -Rattus norvegicus; See PMID 8537300
An01g12690	Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa
An01g12700	Function: the H. sapiens RBQ-3 preferentially binds to underphosphorylated pRB.; Title: similarity to retinoblastoma protein binding protein RBQ-3 - Homo sapiens; See PMID 7558034
An01g12710	Catalytic activity: n nucleoside triphosphate = n pyrophosphate + rna(n).; Function: RNA polymerase II catalyzes transcription of mRNA and U1-U5 snRNA.; Remark: RNA polymerase II consists of about 12 to 15 different subunits.; Title: strong similarity to largest subunit of DNA-directed RNA polymerase II rpb1p - Schizosaccharomyces pombe; nucleus
An01g12720	Similarity: patentmatch against tumour suppressor TSA305 protein Y17750 Patentprot.; Title: similarity to tumour suppressor protein TSA305 from patent WO9928457-A1 - Homo sapiens
An01g12730	Similarity: similarities correspond to multiple T-and P-repeats.; Title: similarity to hypothetical protein EAA65640.1 - Aspergillus nidulans
An01g12740	Function: p40 and Rab9 presumably act together to drive the process of transport vesicle docking.; Remark: the H. sapiens p40 gene product binds to Rab9 GTP, required for the transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network.; Title: similarity to Rab9 effector p40 - Homo sapiens; See PMID 9230071
An01g12750	Function: the H. sapiens CDC20 protein directly binds to anaphase-promoting complex during mitosis and G1,and activate its cyclin ubiquitination activity.; Title: strong similarity to cell cycle protein CDC20 - Homo sapiens; nucleus; See PMID 9811605; See PMID 10793135; See PMID 9734353
An01g12760	Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408
An01g12770	Remark: Functional assays establish that H. sapiens TFIIA has no apparent role in basal transcription but plays an important role in activation of transcription.; Remark: H. sapiens TFIIA can be an integral component of the preinitiation complex.; Remark: the gene for human protein TFIIA alpha encodes a fusion protein of the two subunits p35 and p19.; Title: strong similarity to large subunit of transcription initation factor TFIIA p35/p19 - Homo sapiens; nucleus
An01g12780	Function: S. cerevisiae Sfp1p regulates the expression of gene products involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response,for example does overexpression of Sfp1p induce the expression of Pds1p, which is known to regulate the G2 checkpoint.; Function: the S. cerevisiae homolog Sfp1p acts as a repressor of the G2/M transition, both in the normal cell cycle and in the G2 checkpoint pathway.; Localization: S. cerevisiae Sfp1p is a nuclear protein with two Cys2His2 zinc-finger domains commonly found in transcription factors.; Title: strong similarity to split zinc finger protein 1 Sfp1 - Saccharomyces cerevisiae; nucleus
An01g12800	Title: strong similarity to hypothetical conserved protein SPAC16.04 - Schizosaccharomyces pombe
An01g12810	Remark: the systematic name of the matching S. cerevisia protein is YKL065c.; Similarity: the ORF shows strong similarity to EST SEQ ID NO:6241 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to BAX-associated protein fragment SEQ ID NO:242 from patent WO200264766-A2 - Saccharomyces cerevisiae
An01g12820	Function: mdm12 from S. pombe is required for mitochondrial inheritance.; Localization: mdm12 is an integral component of the outer mitochondrial membrane.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:6793 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to mitochondrial inheritance component mdm12p - Schizosaccharomyces pombe; localisation:mitochondrion
An01g12850	Title: strong similarity to EST an_3045 -Aspergillus niger
An01g12910	Title: strong similarity to hypothetical protein kinase Kin3 - Saccharomyces cerevisiae
An01g12940	Title: weak similarity to hypothetical protein CAC17479.1 - Homo sapiens
An01g12950	Title: similarity to hypothetical protein PA0544 -Pseudomonas aeruginosa
An01g12960	Catalytic activity: H. sapiens homolog ACADSB activity goes toward the short branched chain acyl-CoA derivatives ((S)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA), as well as toward the short straight chain acyl-CoAs (butyryl-CoA and hexanoyl-CoA).; Function: The acyl-CoA dehydrogenases (ACDs) are a family of mitochondrial enzymes that oxidize straight chain or branched chain acyl-CoAs in the metabolism of fatty acids or branched chain amino acids.; Title: strong similarity to short/branched chain specific acyl-CoA dehydrogenase precursor ACADSB - Homo sapiens; localisation:mitochondrion
An01g12970	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:6160 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to hypothetical protein T24H10.2 -Caenorhabditis elegans
An01g12990	Title: strong similarity to hypothetical membrane protein YJL091c - Saccharomyces cerevisiae
An01g13000	Function: the heterotrimeric Thermus thermophilus asp-tRNAasn amidotransferase also generates gln-tRNAgln.; Similarity: bears strong sequence similarity to amidase superfamily.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:4067 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to glu/asp-tRNA amidotransferase subunit A gatA - Thermus thermophilus; See PMID 10913601
An01g13010	Catalytic activity: nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.; Function: the C. albicans homolog PDE1 complements a S. cerevisiae PDEase-deficient mutant. It belongs to the cAMP phosphodiesterases class-II and hydrolyses both cAMP and cGMP.; Remark: C. albicans PDE1 shares a putative protein kinase A (PKA) phosphorylation site with S. cerevisiae PDE1, suggesting a possible regulation by PKA-dependend phosphorylation.; Repression: C. albicans PDE1 is only moderately inhibited by millimolar concentrations of standard PDEase inhibitors.; Title: strong similarity to cyclic nucleotide phosphodiesterase PDE1 - Candida albicans
An01g13030	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:5871 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical protein 68B2.90 - Neurospora crassa
An01g13040	Catalytic activity: H. sapiens PEPD hydrolyses Xaa-|-Pro dipeptides, also acts on aminoacyl-hydroxyproline analogs, but shows no action on Pro-|-Pro.; Function: the human homolog PEPD is a proline specific metallo-peptidases.; Remark: prolidase (peptidase D) deficiency upsets skin healing and facilitates the occurrence of chronic cutaneous ulcerations.; Title: strong similarity to prolidase PEPD from patent JP02104286-A - Homo sapiens; cytoplasm
An01g13060	Title: strong similarity to EST an_2136 -Aspergillus niger
An01g13070	Complex: S. cerevisiae Sec63p is subunit of the ER translocon.; Function: S. cerevisiae Sec63p is the functional signal recognition particle receptor of the ER protein translocation machinery (translocon) which is responsible for translocation of nascent secretory proteins across the ER membrane and also patricipates in the retrograde proteasome/ubiquitin dependent ER degradation.; Remark: former name Npl1p of S. cerevisiae homolog Sec63p is obsolete.; Title: strong similarity to signal recognition particle receptor Sec63 - Saccharomyces cerevisiae
An01g13080	Function: the S. pombe homolog ntf1 is a transcription factor involved in regulating nmt1+ expression.; Similarity: S. pombe ntf1 shares substantial homology with a family of Cys6 zinc finger-containing transcription factors typified by GAL4 from S. cerevisiae.; Similarity: the ORF is shorter than nft1 of S. pombe (344 compared to 706 amino acids). The two proteins show a local N-terminal similarity over a stretch of about 100 amino acids.; Title: similarity to thiamin repressible genes regulatory protein ntf1p - Schizosaccharomyces pombe
An01g13100	Similarity: the ORF shows strong similarity to expressed sequence tag an_3084 from Aspergillus niger.; Title: strong similarity to hypothetical protein AAN61518.1 - Caenorhabditis elegans
An01g13120	Function: Arl2 interacts with the tubulin-specific chaperone protein known as cofactor D by downregulating the tubulin GAP activity of C, D, and E, and inhibits the binding of D to native tubulin in vitro.; Function: Cofactors C, D, and E assemble the alpha/beta- tubulin heterodimer and also interact with native tubulin, stimulating it to hydrolyze GTP and thus acting together as a beta-tubulin GTPase activating protein (GAP).; Remark: the ADP ribosylation factor-like proteins (Arls) are a family of small monomeric G proteins.; Title: strong similarity to ADP-ribosylation factor-like 2 protein ARL2 - Mus musculus; See PMID 10831612
An01g13130	Function: PTC is a glutamine synthase inhibitor, a herbicide and a component of the antibiotic phosphinotricyl-alanyl-alanine (PTT).; Similarity: shows only partial similarity to patented protein because it is much larger.; Title: weak similarity to phosphinothricin-resistance protein from patent EP0290986 -Alcaligenes faecalis
An01g13150	Function: enzyme of S. cerevisiae is involved in ribosom assembly.; Similarity: belongs to the 'DEAD' box family helicase.; Similarity: shows also strong similarity to hypothetical protein from S. pombe.; Title: strong similarity to ATP dependent RNA helicase Drs1 - Saccharomyces cerevisiae; nucleus; See PMID 1454790; See PMID 8247005
An01g13160	Catalytic activity: 3-carboxy-3-hydroxy-4-methylpentanoate + CoA = acetyl-CoA + 3-methyl-2-oxobutanoate + H2O.; Function: catalyzes the condensation of acetyl-CoA and 2-oxoisovalerate to form 2-isopropylmalate.; Localization: mitochondrial and cytoplasmic.; Pathway: first step in leucine biosynthesis.; Remark: a single nuclear gene produces two forms by use of alternative initiation codons in the same reading frame.; Similarity: belongs to the alpha-ipm synthetase/homocitrate synthase family.; Title: strong similarity to alpha-isopropylmalate synthase Leu4 - Saccharomyces cerevisiae
An01g13170	Function: CPS1 product is described as peptide synthetase-like protein.; Similarity: similar to S. pombe hypothetical protein: SwissProt Accession Number Q10250, S. cerevisiae probable membrane protein YOR093c: PIR Accession Number S61654, S. verticillus bleomycin peptide synthetase BlmVI encoded by GenBank Accession Number AF210249, M. xanthus saframycin Mx1 synthetase SafB: PIR Accession Number T1855; similar to Pfam domain PF00501; Title: strong similarity to hypothetical peptide synthase-like protein CPS1 - Cochliobolus heterostrophus
An01g13180	Similarity: shows only partial similarity to the human protein.; Title: weak similarity to serine-threonine kinase STK9 - Homo sapiens
An01g13190	Complex: ribosomal protein S5. e of S. cerevisiae is a part of the ribosome.; Function: ribosomal protein S5. e of S. cerevisiae is involved in protein biosynthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S5.e - Saccharomyces cerevisiae; cytoplasm
An01g13200	Function: pharmaceutical compositions comprising FLEXHT can be used to treat diseases or conditions associated with altered expression of functional FLEXHT.; Function: the polynucleotide sequences of the patent can be used to express the protein sequences.; Function: the proteins and polynucleotides of the patent can be used to diagnose and treat disorders.; Similarity: shows stronger similarity to several hypothetical protein from S. cerevisiae, S. pombe, D. melanogaster, etc.; Title: similarity to FLEXHT-10 from patent WO200070047-A2 - Homo sapiens
An01g13210	Similarity: shows only partial similarity to spd1.; Title: weak similarity to S phase inhibitor spd1p -Schizosaccharomyces pombe
An01g13220	Function: neither heat shock nor a range of other stimuli, including hydrogen peroxide, cobalt chloride,2-deoxyglucose, or tunicamycin, led to its expression,suggesting selectivity for production of ORP150 in response to oxygen deprivation, i. e. it was an oxygen-regulated protein (ORP150).; Title: strong similarity to 150 kDa oxygen regulated protein ORP150 - Rattus norvegicus; See PMID 8617779
An01g13230	Function: the patented sequences (DNA database) can be used to treat and diagnose cancer and cell proliferative, autoimmune/inflammatory, vesicle trafficking,neurological, cardiovascular, cell motility, reproductive and muscle disorders.; Similarity: shows higher similarity to hypothetical proteins.; Title: similarity to cytoskeleton-associated protein 4 from patent WO200017355-A2 - Homo sapiens
An01g13240	Title: similarity to hypothetical protein CAE75736.1 - Neurospora crassa
An01g13250	Title: similarity to hypothetical protein YKL047w -Saccharomyces cerevisiae
An01g13260	Function: EBP is suggested to be the first structurally characterized member of a family of high affinity microsomal drug acceptor proteins carrying so called sigma-binding sites.; Function: EBP shared structural features with pro-and eukaryotic drug transport proteins.; Function: the emopamil-binding protein (EBP) acts as a high affinity acceptor for several antiischemic drugs and thus represents a potential common molecular target for antiischemic drug action.; Title: strong similarity to emopamil-binding protein - Cavia porcellus; See PMID 7706302
An01g13270	Complex: the SRm160/300 splicing coactivator,consists of the serine/arginine (SR)-related nuclear matrix protein of 160 kDa and a 300-kDa nuclear matrix antigen.; Function: it functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA, including snRNPs and SR family proteins.; Similarity: shows only partial similarity to several protein having repetitive sequences.; Title: similarity to splicing coactivator subunit SRm300 - Homo sapiens; See PMID 10668804; See PMID 11004489
An01g13280	Complex: human Rad54B, like human Rad54 (hRad54),associates with human Rad51 (hRad51) through their NH(2)-terminal domains.; Function: human Rad54B is involved in mitotic and meiotic recombination and repair.; Remark: human RAD54B is highly homologous to mammalian RAD54.; Remark: in contrast to Rad54, whose association with Rad51 is induced by ionizing radiation, Rad54B associates with Rad51 constitutively in immunoprecipitation experiments.; Similarity: the predicted A. niger protein shows strong similarity to huamn RAD54B, which belongs to the SNF2 superfamily, with sequence motifs similar to those in DNA and RNA helicases.; Title: strong similarity to RAD54B - Homo sapiens; See PMID 9409819; See PMID 9409820; See PMID 9335591
An01g13290	Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793; See PMID 8720066; See PMID 9348664
An01g13320	Function: the product of M. grisea pathogenicity gene pth11 is not required for appressorium morphogenesis but is involved in host surface recognition.; Similarity: shows only partial similarity to protein of M. grisea.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An01g13340	Function: the protein of H. pylori demonstrates good protective properties against H. pylori, which has been strongly implicated in chronic active gastritis and peptic ulcer disease.; Remark: the protein of H. pylori was found as hit in patent database against DNA.; Similarity: shows partial similarity to several dehydrogenases and deacetylases.; Similarity: shows similarity at the carboxyterminal only, protein of patent is much shorter.; Title: similarity to 35kDa antigenic protein from patent WO200029432-A1 - Helicobacter pylori
An01g13350	Function: protein of S. cerevisiae binds to damaged proteins and actively participates in an emergent rescue function as a molecular chaperone.; Function: protein of S. cerevisiae is important for reactivation of mRNA splicing after heat shock, assists in the repair of the splicing apparatus. .; Function: protein of S. cerevisiae is involved in barotolerance that is temperature dependent.; Function: protein of S. cerevisiae is most likely a disaggregator of proteins during hydrostatic pressure stress.; Function: protein of S. cerevisiae is required for thermotolerance ethanol and other stresses.; Function: protein of S. cerevisiae is required in normal amounts for [psi+] phenotype and for conversion of [psi-] to [psi+].; Similarity: shows strong similarity to endopeptidase Clp of several species.; Title: strong similarity to heat shock protein Hsp104 - Saccharomyces cerevisiae; cytoplasm; See PMID 9369220; See PMID 9391130; See PMID 9703962
An01g13360	Similarity: shows only partial similarity to Su(UR)ES of D. melanogaster.; Title: weak similarity to supressor of underreplication Su(UR)ES - Drosophila melanogaster; See PMID 11033777
An01g13370	Similarity: shows similarity to N-terminus only of several N-methyltransferase of Nicotiana spec.; Title: weak similarity to putrescine N-methyltransferase NsPMT1 - Nicotiana sylvestris
An01g13390	Title: similarity to hypothetical protein CAD21062.1 - Neurospora crassa
An01g13400	Function: the S. cerevisiae Gim3 protein (prefoldin 4 homolog) binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.; Remark: alternate names for S. cerevisiae Gim3: Pfd4 or YNL153C.; Title: strong similarity to homolog of the prefoldin subunit 4 Gim3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9463374
An01g13410	Function: the cutinase transcription factor 1 CTF1alpha from Fusarium solani positively acts in vivo by binding selectively to palindrome 2 of the cutinase gene promoter. This has been shown in the heterolog S. cerevisiae system.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical transcription factor B14D6. 340 from Neurospora crassa.; Title: similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694
An01g13420	Title: weak similarity to hypothetical protein CG8621 - Drosophila melanogaster
An01g13430	Title: weak similarity to desaturase homologue from patent WO9846764-A1 - Schizochytrium sp.
An01g13440	Title: weak similarity to hypothetical protein AAF13358.1 - Eufolliculina uhligi
An01g13450	Title: similarity to hypothetical protein B9B15.40 -Neurospora crassa
An01g13460	Title: strong similarity to hypothetical protein B9B15.50 - Neurospora crassa
An01g13470	Title: similarity to topoisomerase II binding protein TopBP from patent JP11075856-A - Homo sapiens
An01g13480	Title: strong similarity to protein SEQ ID NO:7805 from patent WO200253728-A2 - Candida albicans
An01g13490	Catalytic activity: Acyl-CoA + H(2)O <=> CoA + a carboxylate.; Complex: the human acyl-CoA thioesterase II was isolated as an HIV nef-binding protein by yeast two-hybrid system.; Remark: the human acyl-CoA thioesterase II (trembl|HSRNATII_1;Pubmed 10807905) is identical to the hACTE-III protein (pir|JC5644; Pubmed 9299485).; Similarity: human acyl-CoA thioesterase II is homologous to E. coli thioesterase II but to none of the mammalian thioesterases.; Title: strong similarity to thioesterase II hTE -Homo sapiens; See PMID 9299485; See PMID 10807905
An01g13510	Function: the Sequence 5 from Patent WO0077222 (S. natalensis) is encodes a protein involved at the biosynthesis of pimaricin.; Remark: Pimaricin is an archetype polyene, important in the food industry as a preservative to prevent mould contamination of foods, produced by Streptomyces natalensis. Polyene macrolides are a class of large macrocyclic polyketides that interact with membrane sterols, having antibiotic activity against fungi but not bacteria.; Title: similarity to protein sequence 5 from patent WO0077222 - Streptomyces natalensis
An01g13520	Similarity: B10H4. 010 from N. crassa shows similarity to cholesterol oxidase.; Title: strong similarity to hypothetical protein B10H4.010 - Neurospora crassa
An01g13530	Function: the S. cerevisiae Gpi8 protein is a transamidase involved in the attachment of GPI-anchors to proteins.; Localization: Gpi8 is a 47 kDa type I membrane glycoprotein residing on the luminal side of the ER membrane.; Remark: alternate name for S. cerevisiae Gpi8: YDR331w.; Similarity: S. cerevisiae Gpi8 belongs to peptidase family C13; also known as the hemoglobinase family.; Title: strong similarity to protein involved in the attachment of GPI-anchors to proteins Gpi8 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8978684; See PMID 10727241
An01g13540	Remark: Sna41 from S. pombe is involved in DNA replication and may play some roles in the regulation of DNA replication by the MCM proteins.; Remark: a putative frameshift results in a premature STOP codon.; Remark: the replication licensing factor limits DNA replication to once in a cell cycle and is thought to contain MCM proteins. the Nda4 protein of Schizosaccharomyces pombe is one of the MCM proteins and is involved in DNA replication.; Similarity: the ORF encoded protein shows also strong similarity to Cdc45 from S. cerevisiae, which is also known to be involved in DNA replication (required for initiation of chromosomal DNA replication).; Title: strong similarity to suppressor of nda4 mutation sna41p - Schizosaccharomyces pombe [putative frameshift]; nucleus; putative frameshift; See PMID 9619628
An01g13550	Remark: ORF contains two frameshifts, due to putative sequencing errors.; Title: strong similarity to hypothetical protein AAL60010.1 - Arabidopsis thaliana [putative frameshift]; putative frameshift
An01g13560	Catalytic activity: N ATP + {nucleotide}(M) <=> N diphosphate + {nucleotide}(M+N).; Function: the poly(A) polymerase Pla1 from S. pombe creates the 3' poly(A) tail of mRNA's.; Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to poly(A) polymerase la1p - Schizosaccharomyces pombe [truncated ORF]; nucleus; See PMID 8692700
An01g13570	Catalytic activity: ATP + RNA(n) = pyrophosphate + RNA(n+1).; Remark: C-terminal truncated ORF due to end of contig.; Remark: also acts slowly with CTP. Catalyses template-independent extension of the 3'- and of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing 3'-OH terminal group.; Title: similarity to poly(A) polymerase pla1p -Schizosaccharomyces pombe [truncated ORF]; See PMID 8692700
An01g13580	Remark: strong similarity to Streptomyces clavuligerus protein sequence of orfdwn1 patent WO9833896-A2.; Remark: the present sequence represents the protein sequence of a gene specific for 5S clavam biosynthesis from Streptomyces clavuligerus (SC) and which is not essential for 5R clavam biosynthesis.; Title: strong similarity to clavaminate synthase orfdwn1 from patent WO9833896-A2 - Streptomyces clavuligerus; See PMID 10223939
An01g13590	Catalytic activity: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH.; Pathway: lysine biosynthesis.; Remark: the biosynthesis of the essential amino acid lysine in higher fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which is completely different from the lysine biosynthetic pathway found in plants and bacteria. The penultimate reaction in the alpha-aminoadipate pathway is catalysed by NADPH-dependent saccharopine reductase.; Title: strong similarity to saccharopine reductase LYS3 - Magnaporthe grisea; See PMID 10771443; See PMID 11080625
An01g13600	Function: the S. cerevisiae Mir1 protein should be involved in the mitochondrial protein import (Pubmed 2170848). Its gene has also been cloned as mitochondrial phosphate transport which is responsible for the transport of phosphate groups from the cytosol to the mitochondrial matrix (Pubmed 1840493).; Remark: alternate name for S. cerevisiae Mir1: YJR077C.; Similarity: the ORF DNA sequence is very strong similar to the EST an_3225 Aspergillus niger.; Title: strong similarity to mitochondrial phosphate transport protein Mir1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1840493; See PMID 2170848
An01g13610	Function: this alkaline alpha-amylase from Patent WO0060058 catalyzes the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Title: strong similarity to unnamed ORF encoding a alkaline alpha-amylase sequence 1 from patent WO0060058 -Bacillus sp.
An01g13620	Catalytic activity: ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + phosphate + glutathione.; Pathway: the glutathione synthetase Gsh2 from S. cerevisiae catalyzes the second step of glutathione biosynthesis.; Remark: alternate name for S. cerevisiae Gsh2: YOL049w.; Title: strong similarity to glutathione synthase Gsh2 - Saccharomyces cerevisiae; See PMID 9512666
An01g13630	Title: strong similarity to yaiB from patent FR2807446-A1 - Lactococcus lactis
An01g13640	Function: nirA mediates nitrate induction in Aspergillus nidulans.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; See PMID 1922075
An01g13650	Function: the M. pneumoniae HMW1 protein is component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing hmw proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle.; Title: similarity to cytadherence accessory protein HMW1 - Mycoplasma pneumoniae; See PMID 9495768
An01g13660	Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: the laccase I from E. nidulans catalyzes the oxidation of benzendiol to benzosemiquinone by molecular oxygen. Laccases are a group of multi-copper proteins of low specificity acting on both catechol and p-benzenediol, and often acting also on aminophenols and phenylenediamine. Laccase I from E. nidulans is a p-diphenol oxidase which is needed for synthesis of green conidial pigment.; Remark: the 1990 decribed (Pubmed 2192364) yA gene from E. nidulans encodes the previous 1982 purified laccase I enzyme (Pubmed 7050088), which differs from the laccase II enzyme (Pubmed 6341366).; Title: strong similarity to laccase I precursor yA -Aspergillus nidulans; See PMID 7050088; See PMID 2192364; See PMID 2659435
An01g13670	Title: strong similarity to hypothetical protein CAF06065.1 - Neurospora crassa
An01g13680	Title: similarity to polypeptide SEQ ID NO:41157 from patent WO200171042-A2 - Drosophila melanogaster
An01g13690	Function: the S. cerevisiae Pas7 protein binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. For example it is essential for import of 3-oxoacyl-coa thiolase (a PTS2-containing protein) into peroxisomes. It may direct the thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.; Remark: alternate names for S. cerevisiae Pas7: Pex7, Peb1 or YDR142C.; Title: strong similarity to peroxisome targeting signal receptor Pas7 - Saccharomyces cerevisiae; cytoplasm; See PMID 8636211; See PMID 8670791
An01g13700	Function: the Crz1 protein from S. cerevisiae is a zinc finger transcription factor that acts via the CDRE UAS element (calcineurin-dependent response element). Crz1 is sufficient to confer calcineurin-dependent transcriptional induction of the FKS2 structure gene, which encodes a beta-1,3 glucan synthase.; Remark: alternate names for S. cerevisiae Crz1: Hal8, Tcn1 or YNL027W.; Title: similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; nucleus; See PMID 9407035
An01g13710	Protein sequence is in conflict with the conceptual translation; Function: the human 'lodestar' homolog shows similar properties as the original 'lodestar' protein from Drosophila, it displayed a strong double-stranded DNA-dependent ATPase activity that was inhibited by single-stranded DNA and exhibited RNA polymerase II termination activity.; Similarity: the human 'lodestar' homolog belongs to the SWI2/SNF2 protein family of DNA dependent ATPases.; Title: strong similarity to homolog of the lodestar ATPase - Homo sapiens [putative sequencing error]; nucleus; putative sequencing error; See PMID 9748214
An01g13720	Similarity: the ORF shows strong similarity to the A. niger EST an_3546.; Title: strong similarity to hypothetical protein encoded by An12g06470 - Aspergillus niger
An01g13730	Remark: the proeteinsequence shows glutamin arginin rich repeat domain.; Title: strong similarity to hypothetical protein encoded by An01g13710 - Aspergillus niger
An01g13740	Title: similarity to hypothetical protein EAA33322.1 - Neurospora crassa
An01g13750	Title: similarity to hypothetical DNA repair system protein alkB - Xanthomonas axonopodis
An01g13760	Title: weak similarity to hypothetical cytochrome c-type protein NapB precursor PA1173 - Pseudomonas aeruginosa
An01g13770	Similarity: N-terminal to ubiquitin-conjugating enzymes.; Title: weak similarity to crossbronx cbx -Drosophila melanogaster
An01g13780	Remark: the protein shows repetitive sequences.
An01g13790	Function: proteins containing homeobox domains are likely to play an important role in development and most are known to be sequence-specific DNA-binding transcription factors.; Remark: the protein shows only similarity in the DNA-binding homeodomain.; Title: weak similarity to homeodomain protein Prep-1 - Homo sapiens; See PMID 9482739; See PMID 9482740
An01g13810	Catalytic activity: ATP + Urea + CO2 = ADP + Orthophosphate + Urea-1-carboxylate.; Pathway: urea cycle and metabolism of amino groups; nitrogen metabolism.; Remark: DUR1,2 in S. cerevisiae is induced by the presence of allophanate, the last intermediate of the allantoin degradative pathway.; Remark: expression of allantoin pathway genes is subject to induction and nitrogen catabolite repression.; Title: strong similarity to urea amidolyase Dur1 -Saccharomyces cerevisiae; See PMID 1802034; See PMID 1938916
An01g13820	Title: strong similarity to protein sequence SEQ ID NO:18221 from patent EP1074617-A2 - Homo sapiens
An01g13830	Title: strong similarity to GTP-binding protein cgtA - Caulobacter crescentus
An01g13880	Remark: resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h+ antiporter.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: similarity to tetracycline resistance protein TetR - Pasteurella multocida; See PMID 8109938
An01g13890	Remark: the uaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: to GAL4 zinc binuclear cluster proteins.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421
An01g13900	Similarity: to dnaJ molecular chaperones.; Title: similarity to hypothetical protein dnajp -Schizosaccharomyces pombe
An01g13910	Remark: ELO1 is a gene involved in the elongation of the fatty acid 14:0 to 16:0.; Remark: synonyms for elo1: YJL196c.; Title: similarity to fatty acid elongation protein Elo1 - Saccharomyces cerevisiae; See PMID 8702485; See PMID 9546663
An01g13920	Catalytic activity: GTP + IMP + L-Aspartate = GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP.; Pathway: purine metabolism; alanine and aspartate metabolism.; Remark: adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP,thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP.; Title: strong similarity to adenylosuccinate synthase ade2p - Schizosaccharomyces pombe; See PMID 10496970; See PMID 1448066
An01g13930	Catalytic activity: succinate + acceptor = fumarate + reduced acceptor; Pathway: citrate cycle (TCA cycle); oxidative phosphorylation; butanoate metabolism; reductive carboxylate cycle (CO2 fixation); electron Transport System, Complex II.; Remark: succinate dehydrogenase (EC 1. 3. 99. 1) is an intrinsic bacterial or inner mitochondrial membrane protein that catalyses the oxidation of succinate and donates electrons to the respiratory chain via quinone acceptors.; Title: similarity to succinate dehydrogenase -Saccharomyces cerevisiae; See PMID 8120006
An01g13940	Function: Maf proteins are a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.; Similarity: the ORF shows similarity to the N-terminal half of H. sapiens cetylserotonin methytransferase-like protein ASMTL, representing the part of the unique fusion product, which is homologous to the bacterial maf/orfE genes.; Title: strong similarity to septum formation protein maf - Bacillus subtilis; See PMID 8387996; See PMID 9736779; See PMID 10747295
An01g13950	Remark: Mlx act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors.; Remark: the predicted protein shows a basic-helix-loop-helix-leucine zipper motif.; Remark: transcriptional repression by Mad1:Mlx heterodimers is dependent on dimerization, DNA binding, and recruitment of the mSin3A. HDAC corepressor complex.; Title: similarity to MAX-like bHLHZIP protein MLX -Homo sapiens; See PMID 10593926
An01g13960	Title: weak similarity to nucleolin DNCHNL - Gallus gallus; See PMID 2114180
An01g13980	Remark: the homology is only in the C-terminal part of the protein.; Title: weak similarity to exo-alpha-sialidase TCNA -Trypanosoma cruzi; See PMID 1711561
An01g13990	Remark: weak similarity to part of the atropin protein.
An01g14000	Catalytic activity: (3R)-3-Hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-Oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: fatty acid biosynthesis.; Remark: chnA contains to a cyclohexanol oxidation gene cluster.; Remark: exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013
An01g14010	Catalytic activity: 4 Benzenediol + O2 = 4 Benzosemiquinone + 2 H2O.; Remark: laccases are a group of multi-copper proteins of low specificity. Act on both O- and P-quinols,and often acting also on aminophenols and phenylenediamine.; Remark: the semiquinone may react further either enzymically or non- enzymically.; Title: strong similarity to brown 2 protein abr2 -Aspergillus fumigatus; See PMID 10515939
An01g14020	Remark: aflR function is conserved between Aspergillus spp. and that aflR expression is sufficient to activate genes in the ST pathway.; Remark: the protein seems approximately 200 amino acids longer, but there is a wide lenght variety in transcription regulators.; Similarity: to unassigned GAL4-type zinc cluster proteins.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194
An01g14030	Remark: there is a small glutamin rich region which maps to many other proteins.; Title: similarity to hypothetical protein CAD21072.1 - Neurospora crassa
An01g14040	Title: weak similarity to finger protein spalt major Dvirsalm - Drosophila virilis; See PMID 7905822
An01g14050	Remark: APC4 homologues are required for metaphase-to-anaphase transitions during meiosis and mitosis.; Remark: anaphase-promoting complex is composed of eight protein subunits, including APC4.; Title: similarity to anaphase-promoting complex subunit 4 APC4 - Homo sapiens; See PMID 9469815
An01g14070	Remark: proteins that contain nuclear localization sequences are recognized in the cytoplasm and delivered to the nucleus by the heterodimeric importin complex.; Remark: the S. cerevisiae protein KAP95 is involved in nuclear import; required for the docking of import substrate to the nuclear membrane/pore; identified as an rna1-1 synthetic lethal.; Similarity: to importin beta chains of many organisms; Title: strong similarity to karyopherin beta Kap95 -Saccharomyces cerevisiae; See PMID 9238021; See PMID 10831607
An01g14080	Remark: YS24 is part of the small (40S) ribosomal subunit.; Remark: synonyms are S24, YS22, RP50, YP58.; Similarity: YS24 of S. cerevisiae belongs to S8 protein family.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Ys24 - Saccharomyces cerevisiae; cytoplasm; See PMID 6814480; See PMID 4000930
An01g14090	Remark: homology to patent EP0999284; Title: similarity to sequence 13 from patent EP0999284 - Candida albicans
An01g14100	Remark: Herp is the first integral membrane protein regulated by the ER stress response pathway. Both the N and C termini face the cytoplasmic side of the ER; this membrane topology makes it unlikely that Herp acts as a molecular chaperone for proteins in the ER.; Title: weak similarity to stress protein Herp - Mus musculus
An01g14110	Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Pathway: glycine, serine and threonine metabolism; glycerolipid metabolism; Remark: phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria.; Title: strong similarity to phosphatidylserine decarboxylase 1 Psd1 - Saccharomyces cerevisiae; See PMID 8227017; See PMID 8407984
An01g14120	Catalytic activity: cleavage at Xaa+ bonds in which Xaa carries a hydrophobic, basic or acidic sidechain; Remark: proteasomes are large, multisubunit particles that act as the proteolytic machinery for most regulated intracellular protein breakdown in eukaryotic cells.; Remark: the protein seems approximately 300 aa to long.; Title: similarity to proteasome alpha subunit ProsMA5 - Drosophila melanogaster; See PMID 9409776; See PMID 9647634
An01g14130	Catalytic activity: 3-Carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-Carboxy-4-methyl-2-oxopentanoate + NADH.; Gene-ID: leu2A; Pathway: valine, leucine and isoleucine biosynthesis; Remark: in A. niger are two highly divergent,differentially regulated, isozymes for beta-isopropylmalate dehydrogenase present.; Remark: the differences in the sequence might be caused by strain variations or sequencing errors.; See PMID 8781173
An01g14140	Catalytic activity: CDPdiacylglycerol + myo-Inositol = CMP + Phosphatidyl-1D-myo-inositol.; Pathway: glycerolipid metabolism.; Remark: a splice site was detected upstream of the START codon.; Remark: the CDPdiacylglycerol--inositol 3-phosphatidyltransferase was abundantly expressed in rat brain and kidney.; Title: strong similarity to CDPdiacylglycerol--inositol 3-phosphatidyltransferase -Rattus norvegicus; See PMID 8804431
An01g14160	Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: the protein phosphatase MP2C from Medicago sativa functions as a negative regulator of mitogen activated protein kinase (MAPK) pathways.; Title: similarity to protein phosphatase 2C MP2C -Medicago sativa; See PMID 9465121; See PMID 10571894
An01g14180	Remark: Pad-1 seems to be essential for both asexual and sexual development.; Title: strong similarity to splice factor Pad-1 -Neurospora crassa; See PMID 9578630; See PMID 10801464
An01g14200	Function: Scs7p is required for the hydroxylation of the very long chain fatty acid in yeast.; Remark: alternate names for the S. cereviseae SCS7 gene: FAH1, YMR272C.; Similarity: the Scs7p gene product from S. cerevisiae contains a cytochrome b5-like domain.; Title: strong similarity to fatty acid hydroxylase Scs7 - Saccharomyces cerevisiae; See PMID 9368039; See PMID 9559540
An01g14210	Alternative name: Cephalosporium acremonium.; Catalytic activity: orotidine 5'-phosphate <=> UMP + CO(2).; Pathway: the pyr4 gene product of Acremonium chrysogenum catalyzes sixth and last step in the biosynthesis of pyrimidines.; Title: similarity to orotidine-5-phosphate decarboxylase pyr4 - Acremonium chrysogenum; See PMID 2140299; See PMID 2587233
An01g14230	Title: similarity to hypothetical hydroxyproline-rich glycoprotein like protein CAD21077.1 -Neurospora crassa
An01g14250	Complex: CopD from bovine is the delta subunit of the oligomeric coatamer complex.; Function: the coatomer complex is required for budding from Golgi membranes in Bos taurus.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles.; Remark: the complex is essential for the retrograde Golgi-to-ER transport of dilysine tagged proteins.; Title: strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus; cytoplasm; See PMID 8858162
An01g14280	Similarity: the similarity of the ORF encoded protein to its homologues based mainly on repetitive structures.; Title: weak similarity to hypothetical surface protein AAS - Staphylococcus saprophyticus
An01g14290	Remark: the Arabidopsis thaliana gene product has the protein id: AAF79266. 1.; Title: strong similarity to hypothetical protein F12K21.21 - Arabidopsis thaliana
An01g14310	Function: Sac1p encodes a novel lipid phosphoinositide phosphatase in which specific mutations can cause the sac1 phenotypes by altering the in vivo regulation of the protein.; Function: Sac1p is an important regulator of microsomal ATP transport providing a possible link between inositol phospholipid signaling and ATP-dependent processes in the yeast ER.; Remark: S. cerevisiae sac1 mutants are showing a inositol dependent phenotype.; Remark: Sac1p shares primary sequence homology with a subfamily of cytosolic/peripheral membrane phosphoinositide phosphatases, the synaptojanins which have approximately the same lenght.; Remark: the SAC1 gene product (Sac1p) is an integral membrane protein of the endoplasmic reticulum and the Golgi complex.; Title: strong similarity to lipid phosphoinositide phosphatase Sac1 - Saccharomyces cerevisiae; See PMID 10075922; See PMID 10625610; See PMID 2687291
An01g14330	Protein sequence is in conflict with the conceptual translation; Complex: S. cerevisiae Kap104p binds to its substrates Nab2p, Nab4p/Hrp1p and the small GTPase Ran/Gsp1.; Complex: efficient Ran-GTP-mediated substrate release from Kap104p requires RNA, indicating an interaction between Kap104p and RNA.; Function: Kap104p is a S. cerevisiae nuclear import receptor for two essential mRNA-binding proteins, Nab2p and Nab4p/Hrp1p.; Localization: S. cerevisiae Kap104p shuttles its substrate from the cytoplasm into the nucleus and therefore occurs in both cellular compartments.; Remark: the systematic name for S. cerevisiae KAP104 is YBR017c.; Similarity: S. cerevisiae Kap104p belongs to the beta-karyopherin (or importin) family or proteins.; Title: strong similarity to nuclear import receptor Kap104 - Saccharomyces cerevisiae; putative frameshift; See PMID 8849456; See PMID 10506153
An01g14350	Remark: C-terminal truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Ups2: YDR213W.; Remark: the similarities to the ORF encoded protein are only focused on the Zn(2)-Cys(6) binuclear cluster domain.; Similarity: the ORF encoded protein shows similarity to transcription factors of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to transcription factor Upc2 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9696767
An01g14360	Remark: N-terminal truncated ORF due to the end of contig.; Title: strong similarity to hypothetical protein 68B2.10 - Neurospora crassa [truncated ORF]
An01g14370	Remark: the recombinant uronate reductase and L-gulono-gamma-lactone oxidase from patent DE19604798-A1 can be used in L-ascorbic acid production from D-glucuronic or galacturonic acids.; Title: strong similarity to uronate dehydrogenase from patent DE19604798-A1 - Saccharomyces cerevisiae
An01g14380	Title: strong similarity to hypothetical protein B3E4.80 - Neurospora crassa
An01g14390	Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Title: strong similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 7557402; See PMID 9435787
An01g14400	Remark: the cercosporin toxin resistance protein CRG1 from C. nicotianae is also described patent WO9841082-A1.; Title: similarity to cercosporin toxin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336
An01g14410	Similarity: the O-crystallin from Octopus dofleini is similar to phosphatidylethanolamine-binding proteins.; Title: weak similarity to O-crystallin - Octopus dofleini; See PMID 10350626
An01g14420	Catalytic activity: an epoxide + H(2)O <=> a glycol.; Remark: alternate name for soluble epoxide hydrolase SEH: cytosolic epoxide hydrolase CEH.; Remark: soluble epoxide hydrolase SEH from Homo sapiens: gene name EPHX2.; Similarity: the Human soluble epoxide hydrolase SEH is also described in patent US5445956-A.; Title: similarity to soluble epoxide hydrolase SEH -Homo sapiens; See PMID 8619856; See PMID 8678300
An01g14430	Function: the human SRPK2 kinase (also the SRPK1 kinase) specifically phosphorylates members of the SR family of splicing factors.; Similarity: the ORF encoded protein shows also similarity to the patent WO9938981-A2.; Title: similarity to serine kinase SRPK2 - Homo sapiens; See PMID 9446799; See PMID 9472028
An01g14440	Remark: N-terminal truncated ORF due to the end of contig.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to extracellular matrix protein lustrin A - Haliotis rufescens [truncated ORF]; See PMID 9405458
An01g14450	Remark: C-terminal truncated ORF due to the end of contig.; Remark: alternate name for Leishmania mexicana sap2: lmsap2.; Remark: the ORF encoded protein shows a repetitive structure.; Title: similarity to secreted acid phosphatase 2 precursor sap2 - Leishmania mexicana [truncated ORF]; extracellular/secretion proteins; See PMID 7720697
An01g14460	Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Title: similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257
An01g14480	Function: Atr1 from S. cerevisiae is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. It is a probable ATP-dependent export permease.; Remark: alternate names for S. cerevisiae Atr1: Snq1, YML116W or YM8339. 03.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 9046086; See PMID 2123132
An01g14490	Remark: the ORF shows similarity to ankyrin-repeats,which are believed to mediate protein-protein interactions.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 7937942
An01g14500	Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Function: the P450rm-monooxygenase system in microsomes of R. minuta might function in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: the P450rm gene product from Rhodotorula minuta acts as a bifunctional enzyme with isobutene-forming and benzoate 4-hydroxylase activities.; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702
An01g14510	Function: the S. cerevisiae Sec14 gene product is required for transport of secretory proteins from the golgi complex. It catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro.; Remark: in opposite to S. cerevisiae the SEC14 gene in Y. lipolytica is not essential.; Title: similarity to phosphatidylinositol-phosphatidylcholine transfer protein Sec14 - Yarrowia lipolytica; See PMID 8138566
An01g14520	Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale
An01g14530	Catalytic activity: (S)-2-hydroxy-acid + O(2) <=> 2-oxo acid + H(2)O(2).; Cofactor: FMN.; Pathway: the (S)-2-hydroxy-acid oxidase GOX from S. oleracea catalyzes the second reaction of the photorespiratory pathway (glycolate pathway).; Remark: the (S)-2-hydroxy-acid oxidase GOX from S. oleracea is also described in patent US5834262-A.; Title: strong similarity to (S)-2-hydroxy-acid oxidase GOX - Spinacia oleracea; peroxisome; See PMID 2644287; See PMID 2681790; See PMID 2824469; See PMID 3286256
An01g14540	Title: similarity to hypothetical protein CAD37157.1 - Aspergillus fumigatus
An01g14550	Catalytic activity: Formamide <=> cyanide + H(2)O.; Similarity: the cyanide hydratase Cht from G. sorghi belongs to the nitrilase family.; Title: strong similarity to cyanide hydratase Cht -Gloeocercospora sorghi; See PMID 1382413
An01g14560	Remark: the fungal protein CIH1 from C. lindemuthianum is important for the fungus-host interaction. It is fungally encoded and Northern analysis showed that it is only expressed in planta.; Title: similarity to hypothetical intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; See PMID 9721685
An01g14570	Title: questionable ORF
An01g14590	Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 4578954; See PMID 436831; See PMID 1735726
An01g14600	Function: the endo-1,4-beta-Xylanase B XynB from Aspergillus tubingensis endohydrolysis the 1,4-beta-D-xylosidic linkages in xylans.; Title: strong similarity to endo-1,4-beta-xylanase B xynB from patent WO9414965 - Aspergillus tubingensis
An01g14610	Title: questionable ORF
An01g14620	Induction: the transcript level of the C. albicans HGT1 gene is enhanced in the presence of drugs, e. g. cycloheximide, chloramphenicol and benomyl.; Title: strong similarity to hexose transporter HGT1 - Candida albicans; See PMID 10612724
An01g14640	Title: weak similarity to mucin 5AC - Homo sapiens; See PMID 7826332
An01g14650	Catalytic activity: {(1,4)-alpha-D-galacturonide}(N) + H(2)O <=> {(1,4)-alpha-D-galacturonide}(N-1) + D-galacturonate.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185
An01g14660	Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Similarity: the ORF encoded protein also shows strong similarity to the protein descibed in patent JP09009966-A.; Title: similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257
An01g14670	Function: the polygalacturonase E (PgaE) from A. niger random hydrolysis the 1,4-alpha-D-galactosiduronic linkages in pectate and in other galacturonans.; Gene-ID: pgaE; Remark: the amino acid sequence of the ORF encoded protein differs at two positions to the published PgaE sequence.; Similarity: the ORF encoded protein shows stong similarity to the protein described in patent EP421919-A.; See PMID 9492270
An01g14680	Title: similarity to hypothetical protein SPCC576.01c - Schizosaccharomyces pombe
An01g14690	Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the ORF encoded protein also shows stong similarity to the protein described in patent JP09009966-A.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An01g14710	Title: weak similarity to cytochrome b Cytb -Anthophora pacifica
An01g14720	Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An01g14730	Catalytic activity: 2,5-dihydro-5-oxofuran-2-acetate <=> cis,cis-hexadienedioate.; Cofactor: the cis,cis-muconate lactonizing enzyme I from T. cutaneum uses Manganese as cofactor.; Similarity: the ORF encoded protein is strong similar to some hypothetical proteins, see BlastP list.; Similarity: the ORF encoded protein shows a similarity to the cis,cis-muconate lactonizing enzyme I from T. cutaneum with an e-val. of 0. 065.; Title: similarity to cis,cis-muconate lactonizing enzyme I TcMLE - Trichosporon cutaneum; See PMID 8110801
An01g14740	Catalytic activity: beta-D-glucose + O(2) <=> D-glucono-1,5-lactone + H(2)O(2).; Cofactor: FAD.; Gene-ID: goxC;gox;ggox;god; Mapping: goxC from A. niger is mapped to chromosome II; see list from DSM.; Pathway: the goxC protein from A. niger is involved in the pentose-phosphate pathway.; Remark: the ORF has an irregular internal stop codon due to a putative sequencing error.; putative sequencing error; See PMID 2792372; See PMID 8299156; See PMID 2406261
An01g14750	Title: similarity to hypothetical tol like protein CAD37049.1 - Neurospora crassa
An01g14760	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: the 6-hydroxy-D-nicotine oxidase 6-HDNO from Arthrobacter oxidans from uses FAD as cofactor.; Induction: the expression of the 6-HDNO protein in Arthrobacter oxidans is linked to the presence of nicotine.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 3905431; See PMID 1700696
An01g14770	Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An01g14780	Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532 - Unclassified organism
An01g14790	Function: the nodL gene encodes a chitooligosaccharide O-acetyltransferase.; Remark: Rhizobia secrete specific lipo-chitooligosaccharide signals (LCOs) called Nod factors that are required for infection and nodulation of legumes.; Title: strong similarity to NodL - Rhizobium meliloti; See PMID 8801423; See PMID 10406097; See PMID 1558960
An01g14800	Catalytic activity: digallate + H(2)O <=> 2 gallate.; Similarity: the tannase from Aspergillus oryzae (PubMed 9146733 and 8917102) is identical to patent JP08080196-A.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 9146733
An01g14810	Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: weak similarity to hypothetical protein SPAC19B12.02c - Schizosaccharomyces pombe
An01g14820	Remark: alternate name for S. cerevisiae YNL283c: WSC2.; Similarity: the ORF is about half as long as YNL283c of S. cerevisiae.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to hypothetical membrane protein YNL283c - Saccharomyces cerevisiae
An01g14830	Title: questionable ORF
An01g14840	Title: similarity to hypothetical protein SC4B10.33 - Streptomyces coelicolor
An01g14850	Catalytic activity: ATP + D-gluconate <=> ADP + 6-phospho-D-gluconate.; Function: the GntV gene product from E. coli catalyzes the phosphorylation of D-gluconate to 6-phospho-D-gluconate.; Title: similarity to gluconokinase gntV -Escherichia coli; See PMID 3040894; See PMID 9151423
An01g14860	Catalytic activity: ATP + O-succinylbenzoate + CoA <=> AMP + diphosphate + O-succinylbenzoyl-CoA.; Pathway: the O-succinylbenzoate--CoA ligase MenE of Bacillus subtilis is involved in the menaquinon biosynthesis.; Remark: putative C-terminal truncated ORF due to the end of contig.; Title: similarity to O-succinylbenzoate--CoA ligase menE - Bacillus subtilis [truncated ORF]; See PMID 1629163; See PMID 6780514; See PMID 6780515
An01g14870	Title: weak similarity to hypothetical inner membrane protein - Helicobacter pylori
An01g14880	Catalytic activity: an alcohol + NADP(+) <=> an aldehyde + NADPH.; Remark: alternate names for the alcohol dehydrogenase/aldehyde reductase AKR1A1 from H. sapiens: ALR or ALDR1.; Title: strong similarity to alcohol dehydrogenase/aldehyde reductase AKR1A1 - Homo sapiens; See PMID 10510318; See PMID 2498333
An01g14890	Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus
An01g14900	Induction: transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate.; Remark: the S. cerevisiae gene product Tna1 (=YGR260w) belongs to the Dal5 tranporter family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An01g14910	Function: facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Remark: the ORF encoded protein belongs to the family of GAL4-type zinc cluster transcriptional regulators (Zn(II)2Cys6 transcriptional activator).; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720
An01g14920	Cofactor: manganese or cobalt.; Function: Xaa-Pro aminopeptidases catalyze the release of any N-terminal amino acid, including proline,that is linked with proline, even from a dipeptide or tripeptide.; Remark: the aminopeptidase P (PepQ) from Lactococcus lactis belongs to the class of Xaa-Pro aminopeptidases.; Similarity: the ORF encoded protein shows a higher similarity to the protein described in patent WO9909145-A1,but the patent contains no further functional characterization.; Title: similarity to aminopeptidase P pepP -Lactococcus lactis; See PMID 10543778; See PMID 7770058
An01g14930	Remark: alternate name for S. cerevisiae Git1: YCR098c.; Remark: glycerophosphoinositol can be used by phospholipid biosynthesis in yeast.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9691030
An01g14940	Catalytic activity: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Similarity: the protein shows also similarity to the phospholipase C (EC 3. 1. 4. 3) of Pseudomonas aeruginosa.; Title: similarity to nonhemolytic phospholipase C PC-PLC - Burkholderia pseudomallei; See PMID 10523590
An01g14950	Remark: introduction of the R. etli ans operon (including the ansA gene) into Sinorhizobium meliloti induced growth with asparagine as the sole carbon and nitrogen source.; Title: strong similarity to L-asparaginase II AnsA -Rhizobium etli; See PMID 10930734
An01g14960	Catalytic activity: L-asparagine + H(2)O <=> L-aspartate + NH(3).; Remark: alternate name for S. cerevisiae Asp3: YLR155c.; Similarity: the ORF encoded protein shows also strong similarity to the asparaginase from Erwinia chrysanthemi (patent EP211639-A).; Title: strong similarity to asparaginase II Asp3 -Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 9170245; See PMID 3042786
An01g14970	Pathway: the microsomal delta-12 desaturase from Zea mays (patent WO9411516-A) is involved in the biosynthesis of unsaturated fatty acids.; Remark: EC 1. 14. 99. -. .; Remark: accumulation of the hydroxylase may be controlled post-transcriptionally in Lesquerella fendleri.; Remark: enzyme has oleate delta-12 desaturase activity and oleate 12-hydroxylase activity in Lesquerella fendleri.; Title: strong similarity to bifunctional oleate 12-hydroxylase:desaturase LFAH12 - Lesquerella fendleri; See PMID 9680976
An01g14980	Expression: significant DNA similarities to Aspergillus nidulans EST.; Title: strong similarity to hypothetical protein encoded by An10g00840 - Aspergillus niger
An01g14990	Function: the TRI11 gene product from F. sporotrichioides catalyzes the hydroxylation at C-15 of isotricodermin.; Remark: disruption of TRI11 gene from F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the TRI11 gene product from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An01g15000	Function: it has been proposed that C. carbonum TOXA encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the predicted A. niger protein occurs from a genomic region containing aflatoxin biosynthesis genes.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997
An01g15010	Catalytic activity: A. flavus omtA converts S-adenosyl-L-methionine + sterigmatocystin to S-adenosyl-L-homocysteine + 7-O-methylsterigmatocystin.; Function: A. flavus omtA forms part of the aflatoxin biosynthesis pathway and is involved in the conversion of sterigmatocystin to o- methylsterigmatocystin and dihydrosterigmatocystin to dihydro-o-methylsterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: similarity to O-methyltransferase omtA -Aspergillus flavus; See PMID 7557460
An01g15020	Catalytic activity: A. flavus omtB converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: A. flavus omtB is a demethylsterigmatocystin 6-O-methyltransferase involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: similarity to O-methyltransferase omtB -Aspergillus flavus; See PMID 10806361
An01g15030	Remark: blastp shows significant similarity (41% positives) between the predicted A. niger protein and M. mulatta TCR A but due to shortness of both peptides the calculated probability is low (p=2,4).; Remark: information regarding M. mulatta TCR A has not yet been published and is available from EMBL.; Similarity: the predicted A. niger protein contains a NK-cell receptor motif.; Title: weak similarity to T-cell receptor alpha tcrA - Macaca mulatta
An01g15050	Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to hypothetical protein YDR090c - Saccharomyces cerevisiae [truncated ORF]
An01g15060	Title: similarity to hypothetical protein YDR090c -Saccharomyces cerevisiae
An01g15070	Function: in N. crassa the acr-2 mutation confers acriflavine resistance.; Similarity: N. crassa acr-2 contains a putative Zn(II)Cys6 binuclear DNA-binding domain.; Similarity: similarity is relatively high beteween the N-terminal region of N. crassa acr-2 and the predicted A. niger protein, low for the rest of the sequence.; Similarity: the N-terminus of the predicted A. niger protein contains a low probability putative Zn(II)Cys6 binuclear DNA-binding domain.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704
An01g15080	Title: strong similarity to transposase of Tan1 -Aspergillus niger; See PMID 9003286
An01g15100	Catalytic activity: gibberellin (GA) 7-oxidase oxidizes GA12-aldehyde to GA12 and GA14-aldehyde to GA14 they further metabolise GA12 to four products, two of which are monohydroxylated GA12.; Function: gibberellin (GA) plant hormones are biosynthesized via complex pathways, the final steps of which are catalyzed by 2-oxoglutarate-dependent dioxygenases.; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256
An01g15110	Catalytic activity: benzoate 4-monooxygenases convert benzoate + NADPH2 + O2 to 4-hydroxybenzoate + NADP + H2O.; Function: in A. niger bphA and cprA are the two cytochrome P450s required for the para-hydroxylation of benzoate.; Induction: A. niger bphA is inducible by benzoate.; Similarity: A. niger bphA is a cytochrome P450 of the pisatin demethylase family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 10852481; See PMID 2250647
An01g15130	Function: S. cerevisiae ATR1 is a membrane-associated component of the machinery responsible for pumping aminotriazole, 4-nitroquinoline-N-oxide (and possibly other toxic compounds) out of the cell.; Function: S. cerevisiae cells with multiple copies of ATR1 accumulated less aminotriazole than wild-type cells, whereas cells with the atr1 deletion mutation retained more aminotriazole.; Function: total deletion of the S. cerevisiae ATR1 region coding for a ATP-binding domain leads to 4-nitroquinoline-N-oxide sensitive null-mutants.; Induction: ATR1 transcription is induced by aminotriazole.; Induction: ATR1 transcription is induced by the basic region-leucine zipper transcription factors YAP1 and GCN4.; Similarity: S. cerevisiae ATR1 belongs to the major facilitator family of transmembrane transport proteins.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9287330; See PMID 2123132; See PMID 3280970
An01g15140	Catalytic activity: agmatinase of E. coli catalyzes the reversible reaction H2O + agmatine <=> urea + putrescine.; Complex: agmatinase of E. coli is an homodimer of two speB-encoded polypeptides.; Function: agmatinase of E. coli is part of the second putrescine biosynthetic pathway, and also represents the only pathway for urea biosynthesis in E. coli as no urease is present.; Pathway: agmatinase of E. coli is part of the polyamine biosynthesis, and arginine utilization pathways.; Repression: agmatinase of E. coli is inhibited by L-arginine and L-ornitine.; Similarity: agmatinase of E. coli belongs to the arginase protein family.; Title: strong similarity to agmatinase speB -Escherichia coli; See PMID 2153656; See PMID 3081491; See PMID 3157043
An01g15150	Function: facB of A. nidulans is a major regulatory gene involved in acetamide and acetate utilisation, as indicated by genetic studies.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the predicted ORF shows similarity or strong similarity to several putative transcription factors.; Similarity: the similarity to facB of A. nidulans is particularly strong in the N-terminal region.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An01g15160	Function: dik of H. sapiens exhibit protein kinase activity toward autophosphorylation and substrate phosphorylation.; Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: ankyrin repeats are tandemly repeated modules of about 33 amino acids that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF also contains two ZU5 domains, that are domains of unknown function present in ZO-1 and Unc5-like netrin receptors.; Similarity: the predicted ORF contains two putative ankyrin repeats, which justify many BLASTP matches,comprised dik of H. sapiens.; Title: similarity to protein kinase dik - Homo sapiens; See PMID 10948194
An01g15170	Catalytic activity: aldehyde dehydrogenase catalyzes the following reversible reaction: aldehyde + NAD(+) + H2O <=> acid + NADH.; Function: aldehyde dehydrogenase catalyzes the second step in ethanol utilization, and enables Aspergillus to grow on ethanol as carbon source.; Similarity: aldehyde dehydrogenases represent a large protein family with a wide substrate specificity.; Similarity: the predicted ORF shows a slightly weaker similarity to the aldehyde dehydrogenase gene AldA of A. niger than to the A. nidulans homologue.; Similarity: the predicted ORF shows strong similarity only to the C-terminal part of various aldehyde dehydrogenases; the gene model could not be extended in the N-terminal direction, because there is no similarity with aldehyde dehydrogenase genes at the genomic level in the 5' region.; Title: strong similarity to aldehyde dehydrogenase aldA - Aspergillus nidulans; See PMID 11102439; See PMID 2606357
An01g15180	Catalytic activity: AFAR of R. norvegicus exhibits aldehyde reductase activity and is capable of converting the protein-binding dialdehyde form of AFB1-dihydrodiol to the nonbinding dialcohol metabolite.; Function: AFAR of R. norvegicus and other mammals (comprising humans) is important for the protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1).; Similarity: the predicted ORF shows similarity also to the human CPRM3 protein patented under patentnumber WO9859055-A2 for clinical applications.; Similarity: the predicted ORF shows similarity with other aldo-keto and alcohol reductases, as well as a weaker similarity to some potassium channels of bacteria and plants.; Similarity: the similarity of the predicted ORF to AFAR of R. norvegicus is limited to the C-terminal half of the protein.; Title: similarity to aflatoxin B1 aldehyde reductase AFAR - Rattus norvegicus; See PMID 8234296
An01g15190	Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases require Zn for their activity, and use NAD or NADP as electron exchangers.; Similarity: fdh of M. marinus belongs to the zinc-containing alcohol dehydrogenase family, and to ADH class-III subfamily.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol and aldehyde dehydrogenases, with very wide substrate specificities.; Title: strong similarity to glutathione-dependent formaldehyde dehydrogenase FDH - Methylobacter marinus; See PMID 7926692
An01g15200	Function: PVA of F. oxysporum is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA).; Remark: 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to mature penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum [truncated ORF]
An13g00010	Title: similarity to hypothetical kinetoplast-associated like protein CAD37020.1 - Neurospora crassa
An13g00020	Function: inp52 of S. cerevisiae is involved in vesicle cycling, e. g. protein sorting at the trans-Golgi network probably by acting in membrane formation.; Phenotype: S. cerevisiae inp52 null mutants are viable, but have abnormal vacuoles.; Remark: inp52 of S. cerevisiae is also called YNL106C, SJL2 or hypothetical protein N2160.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760099.; Title: strong similarity to inositol-1,4,5-triphosphate 5-phosphatase Inp52 - Saccharomyces cerevisiae; See PMID 9560389; See PMID 10224048; See PMID 10947947; See PMID 11094088
An13g00030	Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759558.; Similarity: the ORF shows some similarity to the peptidylprolyl isomerase FPR4 of S. cerevisiae.; Title: strong similarity to hypothetical protein YGR280c - Saccharomyces cerevisiae; See PMID 9371805
An13g00040	Catalytic activity: 1-acylglycerol-3-phosphate O-acyltransferases convert Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate.; Function: 1-acylglycerol-3-phosphate O-acyltransferase mr1 of M. ramanniana is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates.; Title: strong similarity to 1-acylglycerol-3-phosphate O-acyltransferase from patent WO200001713-A2 - Mortierella ramanniana
An13g00050	Function: kin1 of U. maydis is required for filamentous growth of the fungi.; Function: kinesins are microtubule associated motors involved in the transport of membrane bound organelles,transport between the endoplasmic reticulum and the Golgi and transport of protein complexes to cellular destinations.; Title: strong similarity to kinesin motor protein kin1 - Ustilago maydis; cytoskeleton
An13g00060	Remark: the real presence of a modified carboxypeptidase-zinc binding PROSITE pattern is questionable.
An13g00070	Function: kin28 is implicated in the transition from transcription initiation to transcription elongation by phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of the RNA polymerase II complex.; Function: kin28 of S. cerevisiae is a subunit of general transcription factor TFIIH, a multiprotein complex required for RNA polymerase II transcription initiation.; Remark: kin28 of S. cerevisiae is also called YDL108W or D2330.; Title: strong similarity to subunit of transcription initiation factor TFIIH protein kinase Kin28 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 9620805; See PMID 9875293
An13g00080	Title: strong similarity to hypothetical conserved protein B2F7.100 - Neurospora crassa
An13g00090	Function: cyp51 of U. necator convers resistance of the obligate biotrophic grape powdery mildew fungus U. necator to sterol demethylation-inhibiting fungicides (DMIs) (a phenylalanine residue for a tyrosine residue at position 136 is leading to a higher resistance).; Function: cyp51 of U. necator is a cytochrome P450-like protein, which catalyses the C14-demethylation of lanosterol, necessary for ergosterol biosynthesis; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.; Remark: cyp51 of U. necator is also called CYPL1,P450-L1A1, sterol 14-alpha demethylase or P450-14DM.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760185.; Title: strong similarity to eburicol 14 alpha-demethylase cyp51 - Uncinula necator
An13g00100	Function: dun1 of S. cerevisiae is involved in DNA repair by serine/threonine-specific protein phosphorylation.; Phenotype: S. cerevisiae dun1 null mutants are defective in DNA damage repair and in DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents.; Remark: dun1 of S. cerevisiae is also called D2370 or YDL101.; Title: strong similarity to protein kinase Dun1 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 10357828
An13g00110	Catalytic activity: stt4 of S. cerevisiae converts ATP + 1-phosphatidyl-1D-myo-inositol <=> ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.; Function: stt4 of S. cerevisiae is acting on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.; Function: stt4 of S. cerevisiae is involved in the regulation of intracellular aminophospholipid transport, a cell cycle checkpoint controller, is important for the maintainance of vacuole morphology and cell wall integrity,and actin cytoskeleton organization by acting in the signal transduction pathway with PKC1.; Phenotype: S. cerevisiae stt4 null mutants have an osmoremedial phenotype, are bleomycin and staurosporine sensitive and arrest mostly in G2/M phase.; Remark: for development of antifungal drugs, the potential of 1-phosphatidylinositol 4-kinase as target is investigated.; Remark: stt4 of S. cerevisiae is also called BLM1,YLR305C or L2142.; Title: strong similarity to 1-phosphatidylinositol 4-kinase Stt4 - Saccharomyces cerevisiae; See PMID 9449533; See PMID 9582361; See PMID 9624007; See PMID 10930462
An13g00140	Function: YT521 of R. norvegicus interats with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate (Sam68) associated during mitosis.; Function: YT521 of R. norvegicus modulates alternative splice site selection in a concentration-dependent manner.; Title: similarity to splicing factor YT521 - Rattus norvegicus; nucleus
An13g00170	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An13g00180	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An13g00210	Similarity: the similarity to csx2 of S. pombe is much weaker than to the N. crassa protein and is only locally high in the C-terminal half of the ORF.; Title: strong similarity to hypothetical protein B14D6.480 - Neurospora crassa
An13g00220	Title: weak similarity to protein fragment SEQ ID NO:54900 from patent EP1033405-A2 - Arabidopsis thaliana
An13g00230	Remark: the ORF is questionable due to its short lenght of only 87 amino acids.; Title: questionable ORF
An13g00240	Function: the role of rad16 in the repair of DNA might be to change the chromatin structure of silenced genes to provide access for excision repair enzymes, but its activity seems not absolutely required for excision repair.; Phenotype: the S. cerevisiae rad16 mutant is deficient for repair of the HML alpha locus.; Remark: rad16 of S. cerevisiae shares homology with the rad54 protein involved in recombinational repair and SNF2, a transcription factor that possibly functions in transcription activation through an interaction with chromatin components that allows access of other factors involved in transcription.; Title: strong similarity to DNA repair protein Rad16 - Saccharomyces cerevisiae; nucleus
An13g00250	Function: rad7 of S. cerevisiae is one of 10 proteins involved in nucleotide excision repair of DNA damaged by UV light, bulky adducts or cross-linking agents.; Phenotype: S. cerevisiae rad7 mutants show partial incision defects.; Remark: rad7 of S. cerevisiae is also called YJR052W or J166.; Title: strong similarity to DNA repair protein Rad7 - Saccharomyces cerevisiae; nucleus; See PMID 9792654; See PMID 9001217
An13g00270	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611
An13g00280	Complex: the S. cerevisiae homolog RPB11 is a RNA polymerase subunit unique to RNA polymerase II.; Title: strong similarity to 13.6 kD subunit of DNA-directed RNA polymerase II Rpb11 - Saccharomyces cerevisiae; nucleus
An13g00290	Function: the S. cerevisiae homolog PAN1 interacts with mRNA 3' ends and conditional mutations in PAN1 lead to an arrest of translation initiation and alterations in mRNA poly(A) tail length. distribution of cytosolic proteins is also affected in some cases.; Remark: alternative gene names for S. cerevisiae homolog are PAN1, MDP3 and MIP3.; Title: strong similarity to poly(A)-specific ribonuclease Pan1 - Saccharomyces cerevisiae
An13g00300	Title: strong similarity to hypothetical protein B14D6.440 - Neurospora crassa
An13g00310	Complex: the S. pombe homolog cnd2 is a subunit of the condensin complex which promotes mitotic chromosome condensation. The condensin complex contains two SMC (structural maintenance of chromosomes) and three non-SMC subunits, one is cnd2.; Localization: condensin subunits tagged with GFP were observed to alter dramatically their localization during the cell cycle, enriched in the nucleus during mitosis, but cytoplasmic during other stages.; Title: strong similarity to condensin complex component cnd2p - Schizosaccharomyces pombe
An13g00320	Title: strong similarity to EST SEQ ID NO:4066 from patent WO200056762-A2 - Aspergillus niger
An13g00330	Remark: a putative sequencing error leads to a frameshift.; putative frameshift
An13g00360	Title: weak similarity to 31K proliferation related acidic leucine-rich protein PAL31 - Rattus norvegicus
An13g00370	Function: Crz1p contains zinc finger motifs and binds specifically to the CDRE (calcineurin-dependent response element) of several target genes in yeast.; Localization: calcineurin dephosphorylates Crz1p and this results in translocation of Crz1p to the nucleus.; Remark: calcineurin effects Ca2+-dependent changes in gene expression through regulation of the Crz1p transcription factor.; Remark: calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a critical role in Ca2+ signaling.; Title: strong similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; nucleus; See PMID 9407035; See PMID 10197980
An13g00380	Title: similarity to hypothetical protein B12J7.160 - Neurospora crassa
An13g00390	Title: strong similarity to hypothetical protein EAA64232.1 - Aspergillus nidulans
An13g00400	Function: synthesis of trehalose in the yeast S. cerevisiae is catalysed by the trehalose-6-phosphate (Tre6P) synthase/phosphatase complex, which is composed of at least three different subunits encoded by the genes TPS1, TPS2, and TPS3; Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TPS3 has regulatory functions.; Remark: the TSL1 and TPS3 genes are identical.; Title: strong similarity to regulator subunit of trehalose-6-phosphate synthase/phosphatase complex Tps3 -Saccharomyces cerevisiae; See PMID 8850521; See PMID 9133641; See PMID 9194697
An13g00410	Title: strong similarity to hypothetical protein CAD28442.1 - Aspergillus fumigatus
An13g00420	Remark: N-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein encoded by An08g03040 - Aspergillus niger [truncated ORF]
An13g00430	Function: ACOB may be a gene that is required for sporulation only at elevated temperatures.; Phenotype: disruption of the acoB gene produces a strain that is thermosensitive for conidiation.; Title: similarity to pre-induction sporulation gene acoB - Aspergillus nidulans; See PMID 7551046
An13g00440	Catalytic activity: URA6 catalyzes the conversion of ATP and UMP to ADP and UDP.; Remark: the alternate gene name for URA6 is SOC8.; Title: strong similarity to uridine-monophosphate kinase Ura6 - Saccharomyces cerevisiae; See PMID 2172245; See PMID 3025561
An13g00450	Title: weak similarity to hypothetical protein encoded by An08g00850 - Aspergillus niger
An13g00460	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An13g00480	Remark: the structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site.; Title: similarity to precursor of triacylglycerol lipase B - Candida antarctica; See PMID 8087556
An13g00510	Induction: expression of hxk1 increases strongly during growth in fructose or glycerol.; Remark: two hexokinases were characterized in Schizosaccharomyces pombe: hxk1, with a low phosphorylation coefficient on glucose (Km 8. 5 mM) and hxk2, a kinetically conventional hexokinase.; Title: strong similarity to hexokinase 1 hxk1p -Schizosaccharomyces pombe; cytoplasm; See PMID 8549830
An13g00520	Title: similarity to EST an_3235 - Aspergillus niger
An13g00540	Title: weak similarity to hypothetical major allergen Phl p 5 - Phleum pratense
An13g00550	Catalytic activity: aroF catalyzes the condensation of erythrose-4-phosphate (E4P) and phosphoenolpyruvate (PEP) to yield DAHP.; Pathway: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase aroF catalyzes the first committed step of the shikimate pathway of the biosynthesis of aromatic amino acids.; Remark: aroF is inhibited by tyrosine.; Title: strong similarity to tyr-inhibited DAHP synthase aroF - Aspergillus nidulans; See PMID 11285739
An13g00560	Function: the csgA mutations of M. xanthus inhibit sporulation as well as rippling; Localization: most of csgA protein in M. xanthus is associated with the extracellular matrix.; Title: similarity to developmental protein C-factor csgA - Myxococcus xanthus; See PMID 1372277; See PMID 2118510; See PMID 2542221
An13g00570	Title: weak similarity to dentin phosphoprotein precursor DPP - Rattus norvegicus
An13g00590	Induction: POT1 is induced approximately 30-fold when oleate is the carbon source.; Phenotype: disruption of POT1 abolishes the ability of Y. lipolytica cells to grow on solid media with oleate as a carbon source.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; See PMID 7916689
An13g00600	Remark: C-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein Rv3439c - Mycobacterium tuberculosis [truncated ORF]
An13g00610	Title: similarity to human secreted protein with SEQ ID NO:128 from patent WO200061627-A - Homo sapiens; extracellular/secretion proteins
An13g00620	Function: G19P1 is an acidic phosphoprotein that is a substrate for protein kinase C in fibroblasts and epidermal carcinoma cells.; Title: strong similarity to 80K protein H precursor G19P1 - Homo sapiens; See PMID 2793184
An13g00630	Remark: Metallothioneins (MTs) may play key roles because of their preferential binding to zinc especially in ageing.; Title: similarity to protein CAP5 - Colletotrichum gloeosporioides; See PMID 11707929
An13g00640	Title: weak similarity to hypothetical protein PA4177 - Pseudomonas aeruginosa
An13g00650	Function: S. cerevisiae TRF5 is required for the establishment of cohesion between sister chromatids, which is coupled to replication fork passage.; Function: S. cerevisiae Trf4 and Trf5 represent the fourth class of essential nuclear DNA polymerases (designated DNA polymerase kappa) and provide a key link in the coordination between DNA replication and sister chromatid cohesion.; Similarity: S. cerevisiae TRF5 and TRF4 are redundant homologs as shown by the viability of single, but lethality of double mutants.; Title: similarity to DNA polymerase kappa Trf5 -Saccharomyces cerevisiae; nucleus; See PMID 10926539
An13g00660	Catalytic activity: L-fucose dehydrogenase converts a D-threo-aldose + NADP(+) to a D-threo-aldono-1,5-lactone + NADPH.; Function: Pseudomonas FDH is involved in carbohydrate utilisation.; Function: Pseudomonas FDH is specific to NADP+ as a hydrogen acceptor.; Title: similarity to L-fucose dehydrogenase FDH -Pseudomonas sp.
An13g00670	Function: S. cerevisiae MIA1 is a mitochondrial protein of unknown function and mia1 mutations lead to respiratory defects.; Remark: information regarding S. cerevisiae MIA1 has not yet been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Remark: the systematic name for S. cerevisiae MIA1 is YJL104w.; Title: strong similarity to mitochondrial protein Mia1 - Saccharomyces cerevisiae; localisation:mitochondrion
An13g00680	Function: Y. lipolytica PEX23 is involved in peroxisomal biogenesis, especially concerning import of peroxisomal proteins.; Function: Y. lipolytica pex23 mutants lack morphologically recognizable peroxisomes and mislocalize all peroxisomal matrix proteins investigated preferentially to the cytosol.; Function: Y. lipolytica pex23 strains accumulate vesicles that contain both peroxisomal matrix and membrane proteins.; Remark: the EMBL entry for PEX22 likely is a typing error and contains a protein sequence identical to the Genbank entry for PEX23.; Title: strong similarity to integral peroxisomal membrane protein PEX23 - Yarrowia lipolytica; peroxisome; See PMID 10637297
An13g00690	Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and N. crassa acr-2, which include the fungal GAL4-type Zn(II)Cys6 binuclear DNA-binding domain.; Title: similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; nucleus; See PMID 8679704
An13g00700	Remark: ORF 5'truncated due to end of contig.
An13g00710	Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Induction: AO-I is highly expressed in A. niger grown on n-butylamine as a single nitrogen source.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: the AO-I aa sequence deviates significantly from the genomic sequence and therefore the two enzymes are probably isoenzymes.; Similarity: AO-I belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; cell wall; See PMID 8620882; See PMID 10896215
An13g00720	Remark: the expression of FLU1 mediated not only resistance to fluconazole but also to cycloheximide.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An13g00730	Function: Cha4p is a positive regulator of CHA1 transcription that is binding UASCHA alone or as part of a complex.; Function: Cha4p of S. cerevisiae activates transcription via serine/threonine response elements in the CHA1 promoter, UASCHA.; Remark: the CHA1 gene of S. cerevisiae encodes the catabolic L-serine (L-threonine) deaminase responsible for the utilization of serine/threonine as nitrogen sources.; Similarity: Cha4p belongs to the superfamily of unassigned GAL4-type zinc cluster proteins.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; nucleus; See PMID 8889513
An13g00740	Catalytic activity: CFA synthase catalyzes the transfer of a methylene from S-adenosyl-L-methionine to an unsaturated fatty acid to form a cyclopropyl fatty acid and S-adenosyl-L-homocysteine.; Function: CFA synthase of Escherichia coli catalyzes a modification of the acyl chains of phospholipid bilayers.; Title: similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli; See PMID 1445840
An13g00750	Title: similarity to hypothetical protein CAD21416.1 - Neurospora crassa
An13g00760	Function: tropomyosin, and by inference actin cables, may facilitate directed vesicular transport of components to the correct location on the cell surface.; Localization: indirect immunofluorescence microscopy reveals that tropomyosin is localized with actin cables in wild-type cells.; Phenotype: disruption of TPM1 results in the disappearance of actin cables from the cytoskeleton and in a reduced growth rate.; Remark: TPM1 encodes the major form of tropomyosin in yeast.; Title: strong similarity to tropomyosin Tpm1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 2649250; See PMID 1629236
An13g00770	Title: strong similarity to hypothetical protein CAD21418.1 - Neurospora crassa
An13g00780	Title: strong similarity to hypothetical protein CAD21419.1 - Neurospora crassa
An13g00790	Title: similarity to CSI2 like protein CAC28732.1 -Neurospora crassa; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An13g00800	Function: It is proposed that Per8p is a component of the molecular machinery that controls the proliferation of peroxisomes.; Induction: in the methylotrophic yeast Hansenula polymorpha the formation of peroxisomes is induced in methanol or methylamine medium.; Localization: Per8p is an integral membrane protein of the peroxisome that is concentrated in the membranes of newly formed organelles.; Phenotype: PER8 mutant cells contain no peroxisome-like structures and peroxisomal enzymes are located in the cytosol.; Remark: Hansenula polymorpha and Pichia angusta are synonymous names referring to the same organism.; Title: strong similarity to peroxisomal integral membrane protein Per8p - Pichia angusta; peroxisome; See PMID 7844145
An13g00810	Title: weak similarity to RecQ-type DNA helicase WRN - Mus musculus
An13g00820	Title: similarity to protein fragment SEQ ID NO:23725 from patent EP1033405-A - Zea mays
An13g00840	Function: GAP1 is the general amino acid permease gene of S. cerevisiae that catalyses active transport of apparently all biological amino acids across the plasma membrane.; Induction: GAP1 activity is regulated according to nitrogen source, the activity being high on urea and low on glutamate; this regulation is due to differential protein sorting from the Golgi complex to either the plasma membrane or the vacuole.; Phenotype: mutations at the GAP1 locus selectively abolish the activity of the general amino acid transport system.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8636059; See PMID 2194797
An13g00850	Title: strong similarity to hypothetical Rho GTPase protein - Schizosaccharomyces pombe
An13g00860	Function: the cdc18 protein is required both for initiation of DNA replication and for coupling mitosis to the completion of S phase.; Induction: transcription of CDC18+ is activated by the transcriptional activator cdc10+ during passage through START.; Remark: cdc18 is a highly unstable protein that is expressed only once per cell cycle at the boundary between G1 and S phase.; Title: strong similarity to cell division control protein cdc18p - Schizosaccharomyces pombe; See PMID 7916658; See PMID 8643672
An13g00870	Title: strong similarity to protein fragment SEQ ID NO:55236 from patent EP1033405-A2 - Arabidopsis thaliana
An13g00890	Function: severin kinase is a kinase from cytosolic extracts that specifically phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein.; Pathway: the presence of severin kinase in Dictyostelium suggests a direct signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Similarity: severin kinase belongs to the Ste20p- or p21-activated protein kinase family.; Title: strong similarity to severin kinase -Dictyostelium discoideum; See PMID 9582328
An13g00910	Function: FacB/acuB is a major regulatory gene involved in acetamide and acetate utilisation.; Phenotype: acuB mutants are unable to grow on acetate as a sole carbon source due to lack of both ACS (acetyl-CoA synthetase) and isocitrate lyase activity.; Similarity: acuB is analogous to the A. nidulans facB regulatory gene.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720
An13g00920	Function: mandelate racemase enables Pseudomonas to utilize (R)-mandelate as sole carbon source.; Title: similarity to mandelate racemase -Pseudomonas putida; See PMID 2831968
An13g00930	Remark: gdhIII is one of four glucose dehydrogenase genes have been cloned from B. megaterium IAM1030.; Title: strong similarity to glucose 1-dehydrogenase gdhIII - Bacillus megaterium; See PMID 1629157
An13g00940	Title: strong similarity to hypothetical protein CAD21281.1 - Neurospora crassa
An13g00950	Title: strong similarity to alcohol dehydrogenase alcB - Aspergillus nidulans; See PMID 8821658
An13g00970	Title: weak similarity to heat shock protein groEL -Streptococcus pyogenes
An13g00980	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An13g01000	Similarity: weak similarity to PATENTPROT entry GENESEQPROT:W71368 (H. sapiens DAP3 protein).; Similarity: weak similarity to hypothetical protein SPBC29A3. 15c of S. pombe.; Title: weak similarity to death associated protein DAP3 from patent WO9839429-A2 - Homo sapiens
An13g01010	Title: strong similarity to hypothetical protein YOR294w - Saccharomyces cerevisiae
An13g01020	Function: RhoGAPs stimulate the activity of Rho-type GTPases.; Pathway: Rho-type GTPases mediate signalling pathways involved in cytoskeleton organization, cell polarization, cell growth and development etc.; Remark: BEM2 of S. cerevisiae is also known as IPL2,SUP9 or TSL1.; Remark: the sytematic gene name of BEM2 of S. cerevisiae is YER155c.; Similarity: the similarity to RhoGAPs of diverse species covers only the GTPase activation domain located in the C-terminal part.; Title: similarity to Rho-type GTPase activating protein Bem2 - Saccharomyces cerevisiae; See PMID 7962097; See PMID 7962098
An13g01040	Catalytic activity: heterotrimeric RABGGT of H. sapiens (alpha1beta1 component B + Rab escort protein, also called component A) catalyzes the transfer of geranylgeranyl (a 20-carbon isoprenoid group) from geranylgeranyl pyrophosphate to both cysteines in Rab proteins with an -xxCC, -xCxC and -CCxx C-terminus.; Function: RABGGTB of H. sapiens is the beta subunit of the heterodimeric (alpha1beta1) catalytic component of Rab geranylgeranyl transferase (RABGGT).; Pathway: Rab GTP-binding proteins modified by RABGGT play an important role in vesicular traffic regulation, eg the control of exocytosis in neuroendocrine and neuronal cells of human brain.; Title: strong similarity to geranylgeranyl transferase type II beta-subunit RABGGTB - Homo sapiens; cytoplasm; See PMID 8706741; See PMID 1525821
An13g01050	Title: strong similarity to acvA gene expression regulator Pc804 from patent WO200257456-A2 - Unclassified organism
An13g01060	Function: swi4 of S. pombe is involved in termination of copy-synthesis during mating-type switching.; Similarity: strong similarity to DNA mismatch repair proteins of the mutS family from diverse species.; Title: strong similarity to mating-type switching protein swi4p - Schizosaccharomyces pombe; nucleus; See PMID 1317550
An13g01070	Complex: RPS28B (RPS33B) in S. cerevisiae forms part of the 40S ribosomal subunit.; Remark: the systematic gene name of RPS28B (RPS33B) from S. cerevisiae is YLR264W.; Title: strong similarity to 40S ribosomal protein S28.e.B RPS 28B Rps33b - Saccharomyces cerevisiae; cytoplasm; See PMID 6196722
An13g01080	Catalytic activity: ATP phosphoribosyltransferase (EC 2. 4. 2. 17) catalyzes the transfer of 5-phospho-D-ribosyl from 5-phospho-D-ribosyl-1-diphosphate to N1 of ATP.; Function: ATP phosphoribosyltransferase in S. cerevisiae is allosterically regulated.; Pathway: ATP phosphoribosyltransferase in S. cerevisiae catalyzes the initial step in histidine biosynthesis.; Remark: his1 of S. pombe complements HIS1 deficiency in S. cerevisiae.; Remark: possible sequencing error at position 28102 or unusual splicing donor site (GC instead of GT).; Similarity: also strong similarity to ATP phosphoribosyltransferase HIS1 of S. cerevisiae.; Title: strong similarity to ATP phosphoribosyltransferase his1p - Schizosaccharomyces pombe [putative sequencing error]; See PMID 7844145; See PMID 385447
An13g01090	Title: strong similarity to hypothetical protein YJR098c - Saccharomyces cerevisiae
An13g01110	Title: similarity to hypothetical protein encoded by An14g05070 - Aspergillus niger
An13g01120	Catalytic activity: LB4D in H. sapiens catalyzes the conversion of leukotriene B4 into 12-oxo-leukotriene B4.; Catalytic activity: LB4D in H. sapiens requires NADP as a cofactor.; Pathway: LB4D in H. sapiens catalyzes the initial and key step of metabolic inactivation of leukotriene B4.; Similarity: LB4D of H. sapiens is homologous to 15-oxoprostaglandin 13-reductase of Sus scrofa (pig) and dithiolethione-inducible gene-1 of Rattus norvegicus (rat).; Similarity: also shows strong similarity to hypothetical quinone oxidoreductases and allyl-alcohol dehydrogenases of various species.; Title: strong similarity to NADP-dependent leukotriene B4 12-hydroxydehydrogenase LB4D - Homo sapiens; See PMID 8576264; See PMID 9461497; See PMID 9667737
An13g01130	Catalytic activity: RhlG in P. aeruginosa catalyzes the reduction of 3-oxodecanoyl-ACP to 3-hydroxydecanoyl-ACP.; Pathway: RhlG in P. aeruginosa is specifically involved in the biosynthesis of rhamnolipids.; Similarity: RhlG in P. aeruginosa is homologous to 3-oxoacyl-(acyl-carrier-protein) reductase FabG.; Similarity: shows similarity to 3-oxoacyl-(acyl-carrier-protein) reductases of various species.; Title: strong similarity to NADPH-dependent beta-ketoacyl reductase RhlG - Pseudomonas aeruginosa; See PMID 9721281
An13g01140	Catalytic activity: serine/threonine-specific protein kinases catalyze the transfer of a phosphate group from ATP to the hydroxyl group of serine or threonine.; Function: Hal4 in S. cerevisiae presumably acts together with Hal5 to activate the Trk1-Trk2 potassium transporter.; Pathway: Hal4 in S. cerevisiae is involved in the coordinate regulation of potassium transport and electrical membrane potential.; Remark: HAL4 of S. cerevisiae is also called SAT4.; Remark: the systematic gene name of HAL4 of S. cerevisiae is YCR008w.; Similarity: the homology covers only the C-terminal part of Hal4 from S. cerevisiae and other serine/threonine-specific protein kinases.; Title: similarity to serine/threonine-specific protein kinase Hal4 - Saccharomyces cerevisiae; See PMID 10207057
An13g01150	Function: probable GTPase-activator protein of Rab-like small GTPases (Rab-GAP).; Localization: drainin in D. discoideum is a peripheral membrane protein associated with the cytoplasmic phase of the vacuolar membrane.; Pathway: drainin in D. discoideum presumably mediates the volume-sensing of the contractile vacuole,leading to the formation of a water discharge channel between the contractile vacuole and the plasma membrane.; Similarity: only the central part shows homology to drainin of D. discoideum and other Rab-GAP-like proteins.; Title: similarity to drainin phgA - Dictyostelium discoideum; See PMID 10369671
An13g01160	Function: telomerase trt1 is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes by means of elongating telomeres.; Remark: Trt1 deletion causes telomere shortening and senescence.; Remark: telomerase trt1 is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.; Similarity: Trt1 belongs to the reverse transcriptase family.; Title: strong similarity to telomerase catalytic chain trt1p - Schizosaccharomyces pombe; nucleus; See PMID 9252327; See PMID 9467843
An13g01180	Remark: MyoM from D. discoideum is the first known unconventional myosin containing an active Rac-GEF domain.; Title: similarity to unconventional myosin heavy chain MyoM - Dictyostelium discoideum; cytoskeleton; See PMID 10828443; See PMID 11208126
An13g01190	Function: the S. cerevisiae Ulp1 protein is a Ubl-specific protease, that cleaves proteins from Smt3 and SUMO-1 but not from ubiquitin.; Remark: protein function can be modulated by ligation to ubiquitin or to ubiquitin-like proteins. SUMO-1 (vertebrates) and Smt3 (S. cerevisiae) are ubiquitin-like proteins (Ubl proteins), they are ligated to cellular proteins. this protein conjugation of SUMO-1/Smt3 to other proteins is involved in many physiological processes.; Remark: yeast Ulp1 has several functions, including an essential role in the G2/M phase of the cell cycle.; Similarity: the hypothetical protein YPL020c of S. cerevisiae is Ubl (ubiquitin-like protein) specific protease 1 (Ulp1p).; Title: similarity to cysteine-type peptidase Ulp1 -Saccharomyces cerevisiae; See PMID 10094048
An13g01200	Title: similarity to insulin receptor substrate protein xIRS-u - Xenopus laevis; See PMID 9717835
An13g01210	Function: pre3 is a subunit of the 20S proteasome involved in ubiquitin-dependent protein degradation.; Remark: pre3 of S. cerevisiae is a subunit necessary or hydrolysis of peptidylglutamyl-peptide.; Title: strong similarity to proteasome 20S subunit Pre3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9677364
An13g01220	Title: strong similarity to hypothetical suppressor of bem1/bud5 bem46p - Schizosaccharomyces pombe; plasma membrane
An13g01230	Title: weak similarity to colon cancer antigen protein SEQ ID NO:4503 from patent WO200122920-A2 - Homo sapiens
An13g01240	Function: the human cysteine-rich transcription factor NF-X1 is a repressor of HLA-DRA transcription. It binds to the X-box motif of class II MHC genes and may play an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon-gamma.; Similarity: the ORF DNA sequence also shows strong similarity to the EST an_1974 from Aspergillus niger.; Title: strong similarity to cysteine-rich transcription factor NF-X1 - Homo sapiens; See PMID 7964459
An13g01250	Function: S. cerevisiae is able to use the bacterial hydroxamate siderophore enterobactin as natural iron source. A enb1 null mutant looses this ability to import 55Fe-enterobactin.; Remark: alternate names for S. cerevisiae Enb1: Arn4 or YOL158C.; Similarity: the S. cerevisiae Enb1 protein belongs to the major facilitator super family (MFS).; Title: strong similarity to siderophore-iron transporter for enterobactin Enb1 - Saccharomyces cerevisiae; See PMID 10831226
An13g01260	Title: similarity to 1,2-alpha-D-mannosidase aman2 -Bacillus sp.; See PMID 8149382
An13g01270	Title: strong similarity to hypothetical protein B11A5.10 - Neurospora crassa
An13g01280	Title: strong similarity to hypothetical protein EAA64035.1 - Aspergillus nidulans
An13g01290	Remark: alternate name for S. cerevisiae Upc2: YDR213w.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism
An13g01300	Catalytic activity: (5-L-glutamyl)-peptide + an amino acid <=> peptide + 5-L-glutamyl-amino acid.; Pathway: the human GGT1 protein plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione.; Remark: the human GGT1 enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.; Title: strong similarity to gamma-glutamyl transpeptidase GGT1 - Homo sapiens; See PMID 2904146; See PMID 1678521
An13g01310	Remark: the human MDB4 protein is identical to the MED1 protein described in patent WO9904626-A1. This patent describes MED1 as a human methyl-CpG binding with an endonuclease activity.; Title: similarity to methyl-CpG binding protein MBD4 - Homo sapiens; nucleus; See PMID 9774669
An13g01320	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to pre-mRNA splicing factor SRp75 - Homo sapiens
An13g01330	Title: weak similarity to hypothetical protein CG7709 - Drosophila melanogaster
An13g01340	Function: the Rhodopsin from Alligator mississippiensis is a visual pigment. It is the light-absorbing molecules that mediate vision. It consists of an apoprotein, opsin and the covalently linked to cis-retinal.; Remark: Alligator mississippiensis=American alligator.; Title: similarity to Rhodopsin - Alligator mississippiensis; plasma membrane; See PMID 8654500
An13g01350	Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An13g01400	Title: weak similarity to protein SEQ ID NO:5202 from patent EP786519-A2 - Staphylococcus aureus
An13g01420	Function: the E. nidulans AflR protein is involved in the regulation of the sterigmatocystin biosynthesis.; Similarity: the ORF encoded protein and the E. nidulans AflR protein are transcriptional regulators of the fungal Zn(2)-Cys(6) binuclear cluster type.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194; See PMID 9680223
An13g01440	Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An13g01450	Function: the Bacteroides fragilis TetX protein has been shown to act by chemically modifying tetracycline in a reaction that appears to require oxygen and NADPH.; Title: strong similarity to tetracycline resistance causing oxidoreductase tetX - Bacteroides fragilis; See PMID 1846135
An13g01460	Remark: the similarity of the ORF encoded protein to the mucin FIM-C. 1 from X. laevis is only based on repetitive structures.; Title: weak similarity to mucin FIM-C.1 - Xenopus laevis
An13g01470	Title: weak similarity to laminin gamma 3 chain precursor LAMC3 - Homo sapiens
An13g01480	Remark: the patent does not provide any further information on the function of the protein.; Similarity: the patent match is against the translated DNA sequence of patent FR2785293-A/43 (AC# AX024100).; Similarity: the predicted A. niger protein shows similarity to several procaryotic hypothetical proteins.; Title: strong similarity to sequence 43 from patent FR2785293-A - Neisseria meningitidis
An13g01490	Similarity: similarity of the predicted A. niger protein is due to low complexity sequences.; Title: weak similarity to hypothetical membrane protein YJR151c - Saccharomyces cerevisiae
An13g01500	Title: weak similarity to hypothetical protein encoded by An15g02450 - Aspergillus niger
An13g01510	Title: similarity to EST an_2981 - Aspergillus niger
An13g01530	Title: weak similarity to hypothetical protein ycnE - Bacillus subtilis
An13g01540	Title: weak similarity to hypothetical protein encoded by An13g01550 - Aspergillus niger
An13g01550	Title: weak similarity to hypothetical protein encoded by An13g01540 - Aspergillus niger
An13g01560	Catalytic activity: receptor tyrosine kinase CCK-2 of patent US5677144-A H. sapiens catalyses the reaction ATP + a protein tyrosine = ADP + protein tyrosine phosphate.; Remark: the protein sequence of human receptor tyrosine kinase CCK-2 of patent US5677144-A (AC# AAW34671) is shorter. the same protein sequence is also covered by patent WO9834954-A2 (AC# AAW77114) and an even shorter protein sequence is covered by patent DE4239817-A (AC# AAR54089). thus, it is not clear whether the full length protein has been cloned yet.; Similarity: the predicted A. niger protein shows local similarity to protein kinases, specifically the amino acids between positions 510 and 600.; Title: similarity to receptor tyrosine kinase CCK-2 from patent US5677144-A - Homo sapiens; deleted EC_number 2.7.1.112
An13g01580	Remark: disruption of the acr-2 gene in N. crassa lead to progenies that were hypersensitive to acriflavine.; Similarity: N. crassa acr-2 is a Gal4 type transcription factor with a fungal Zn(2)Cys(6) DNA-binding domain.; Similarity: the predicted A. niger protein shows similarity to several Zn(2)Cys(6) DNA-binding domain containing proteins.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704
An13g01590	Catalytic activity: cyanamide hydratase of M. verrucaria catalysys the reaction urea = cyanamide + H2O.; Regulation: the enzyme was detectable only when the fungus was grown on cyanamide as the sole nitrogen source.; Remark: cyanamide hydratase containes zinc and consists of six identical subunits with Mr = 27,700.; Remark: cyanamide hydratase of M. verrucaria is covered by the patent WO9848023-A1 (AC# AAW80804).; Similarity: the predicted A. niger protein is strongly similar to cyanamide hydratase of M. verrucaria and the hypothetical protein YFL061w of S. cerevisiae.; Title: strong similarity to cyanamide hydratase -Myrothecium verrucaria; See PMID 2034671
An13g01600	Title: strong similarity to hypothetical protein encoded by An08g01970 - Aspergillus niger
An13g01610	Title: similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe
An13g01620	Title: similarity to hypothetical protein encoded by An11g07000 - Aspergillus niger
An13g01640	Function: the detergent-solubilized complex of terminal quinol oxidase oxidizes caldariella quinol at high rates and is completely inhibited by cyanide and by quinolone analogs, potent inhibitors of quinol oxidases.; Remark: multiple alignments and phylogenetic analysis of the heme-bearing subunit I (DoxB) locate this oxidase at the bottom of the phylogenetic tree, in the branch of heme-copper oxidases recently suggested to be incapable of superstoichiometric proton pumping. this finding is corroborated by lack of the essential amino acid residues delineating the putative H+-pumping channel. it is therefore concluded that A. ambivalens copes with its strongly acidic environment simply by an extreme turnover of its terminal oxidase, generating a proton gradient only by chemical charge separation.; Similarity: the predicted A. niger protein shows homology to subunit I of terminal quinol oxidase of A. ambivalens which belongs to the superfamily of respiratory heme-copper oxidases.; Title: weak similarity to subunit I of terminal quinol oxidase doxB - Acidianus ambivalens; plasma membrane; See PMID 9023221
An13g01650	Remark: 'frezzled-like protein' seems to be the misspelled 'frizzled-like protein'.; Remark: this is the amino acid sequence of the full length human frezzled-like protein (HFLP), used in the method of the invention. it is a member of the frizzled protein family. it is used in the detection and treatment of differentiation-related disorders. in conditions where HFLP is under-expressed, its agonist is involved in the treatment. antagonist and antibodies of HFLP are used in the treatment of disorder where HFLP is over-expressed, e. g. the regulation of haematopoiesis, and wound healing. HFLP products are used to develop products for treating e. g. cancers, inflammatory and autoimmune diseases,infectious diseases and allergic reactions.; Similarity: the predicted A. niger protein shows homology to the protein sequence of patent WO9909152-A1 (AC# AAY03232).; Title: weak similarity to frizzled-like protein from patent WO9909152-A1 - Homo sapiens
An13g01660	Title: strong similarity to EST an_2552 -Aspergillus niger
An13g01680	Catalytic activity: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of. B. lactis catalyses the following reactions: D-fructose 6-phosphate + orthophosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O or D-xylulose 5-phosphate + orthophosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.; Cofactor: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase requires thiamine diphosphate as a cofactor.; Pathway: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of B. lactis is involved in the pentose phosphate cycle, pentose and glucuronate interconversions and aminosugars metabolism.; Similarity: the predicted A. niger protein shows strong similarity to D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of. B. lactis and to hypothetical proteins of several microorganisms.; Title: strong similarity to D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase xfp -Bifidobacterium lactis; See PMID 11292814
An13g01690	Remark: the patented protein is involved in abscission or dehiscence. expression of the protein in a transgenic plant can be used to manipulate plant abscission and reduce/prevent pod dehiscence, especially to regulate abscission of pollen from anthers, to generate male sterile plants and for hybrid seed production.; Remark: the protein sequence of the rape hypothetical protein (SAC25) is covered by the patent WO9423043-A (AC# AAR60800).; Similarity: the predicted A. niger protein shows similarity to putative oxidoreductases.; Title: strong similarity to abscission/dehiscence protein from patent WO9423043-A - Brassica napus
An13g01700	Title: weak similarity to hypothetical protein encoded by An08g05310 - Aspergillus niger
An13g01730	Remark: the nucleotide sequence partially overlaps with the 3'- non coding sequence of A. ficuum acid phosphatase (aphA).; Title: similarity to hypothetical protein encoded by An09g06230 - Aspergillus niger
An13g01740	Remark: the nucleotide sequence overlaps with the 3'- non coding sequence of A. ficuum acid phosphatase (aphA).; Title: similarity to hypothetical protein encoded by An09g06230 - Aspergillus niger
An13g01750	Catalytic activity: the acid phosphatase aphA of A. ficuum catalyses the reaction orthophosphoric monoester + H(2)O = alcohol + orthophosphate.; Gene-ID: aphA;pacA; Regulation: the level of expression of the gene in A. niger is affected by phosphate concentration and pH of the growth medium.; Similarity: the predicted A. niger protein is highly similar (identical amino acids exceed 95%) to the acid phosphatase aphA of A. ficuum and partial sequences of acid phosphatase of A. niger. the protein sequence of TREMBL:AN18554_1 of A. niger lacks the N-terminus, which can be found in the protein sequence of PIR:JT0386 of A. niger. however, this latter sequence shows some discrepancy with downstream segments of the aphA of A. ficuum or A. niger, which might be due to alternative splicing.; See PMID 3224828
An13g01760	Function: OPT1 of C. albicans was cloned from a C. albicans genomic library through heterologous expression in the S. cerevisiae di-/tripeptide transport mutant PB1X-9B. OPT1 restored oligopeptide transport in the mutant cells,as indicated by growth on the tetrapeptide Lys-Leu-Leu-Gly,sensitivity to toxic tetra- and pentapeptides, and an increase in the initial uptake rate of the radiolabelled tetrapeptide Lys-Leu-Gly-[3H]Leu.; Remark: C. albicans oligopeptide transporter OPT1 is probably localized in the plasma membrane.; Remark: the hypothetical protein SPAC29B12. 10c of Schizosaccharomyces pombe is covered by patent WO200052162-A2 (AC# AAY96165). the present sequence is that of an oligopeptide transporter (OPT) family member from S. pombe, designated emb CAB16254. 1. members of the OPT family have been identified in yeasts and plants. the invention relates to a novel OPT of S. cerevisiae,designated OPT1 (see AAY96149). OPT1 is the first example of a genetically defined eukaryotic transport protein which can transport enkephalins across the cell membrane. vectors allowing expression of the OPT1 gene, transgenic plants, and treatment of OPT1p with toxic enkephalins as an antifungal method are claimed. also claimed is a method for obtaining mammalian enkephalin transporters by functional complementation of OPT1 deficient yeast.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; plasma membrane; See PMID 9043116
An13g01770	Title: weak similarity to hypothetical translated cDNA FLJ13744 - Homo sapiens
An13g01780	Remark: new sequence determined DNA fragments (SDFs) from different plant species may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways. its coding sequence has a use in the control of gene expression as a promoter,coding sequence, 3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome,as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Remark: the patent match is against the protein fragment SEQ ID NO: 52620 of patent EP1033405-A2 (AC# AAG42215).; Title: weak similarity to protein fragment SEQ ID NO:52620 from patent EP1033405-A2 - Arabidopsis thaliana
An13g01790	Remark: new sequence determined DNA fragments (SDFs) from different plant species may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways. its coding sequence has a use in the control of gene expression as a promoter,coding sequence, 3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome,as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Remark: the patent does not provide further information about the function of the protein.; Remark: the patent match is against the protein fragment SEQ ID NO: 75858 of patent EP1033405-A2 (AC# AAG58725).; Title: similarity to protein fragment SEQ ID NO:75858 from patent EP1033405-A2 - Arabidopsis thaliana
An13g01800	Title: strong similarity to hypothetical protein encoded by An15g07140 - Aspergillus niger
An13g01810	Catalytic activity: 4-hydroxyacetophenone monooxygenase (HAPMO) of P. fluorescens catalyses the reaction 4-hydroxyphenylacetate + NAD(P)H + O(2) = 3,4-dihydroxyphenylacetate + NAD(P)(+) + H(2)O.; Remark: HAPMO of P. fluorescens is a homodimer of approximately 140 kDa with each subunit containing a noncovalently bound FAD molecule.; Similarity: the predicted A. niger protein and 4-hydroxyacetophenone monooxygenase (HAPMO) of P. fluorescens show homology to flavin-containing monooxygenases.; Title: strong similarity to 4-hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873
An13g01830	Remark: Sak serine-threonine kinase may be useful for identifying modulators potentially useful in treatment or prevention of proliferative disease.; Remark: the patent WO200039322-A1 (AC# AAR92214) covers SAK-b serine-threonine kinase of M. musculus.; Title: weak similarity to SAK-b serine-threonine kinase from patent CA2150789-A - Mus musculus
An13g01840	Catalytic activity: dimethylallyltryptophan synthase of C. purpurea catalyses the reaction dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.; Function: dimethylallyltryptophan synthase of C. purpurea (also known as tryptophan dimethylallyltransferase) is a prenyltransferase, which catalyses the first step in ergot alkaloid biosynthesis.; Remark: ergot alkaloids (EAs), products of Claviceps spp., are widely used in various fields of clinical medicine (neurology, psychiatry, endocrinology).; Remark: the A. oryzae dimethylallyl-cycloacetoacetyl-L-tryptophan synthase (DCAT-S) is involved in the synthesis of beta-CPA, from cyclo-acetoacetyl-L-tryptophan and dimethylallylpyrophosphate, by its homology to a dimethylallyltryptophan synthase (DMAT-S) from Claviceps purpurea. Aspergillus host cells having a modification in the DCAT-S gene, leading to reduced or eliminated toxin production, are useful for expression of heterologous polypeptides of interest. other toxins which may be reduced or eliminated comprise kojic acid, 3-nitropropionic acid,emodin, etc. the DCAT-S gene can be used to identify and disrupt similar genes in other filamentous fungal host strains such as Trichoderma, Penicillium and Fusarium.; Remark: the patent match is against dimethylallyl-cycloacetoacetyl-L-tryptophan synthase (DCAT-S) of A. oryzae, which is covered by patent WO200039322-A1 (AC# AAY96961).; Title: strong similarity to dimethylallyltryptophan synthase dmaW - Claviceps purpurea; See PMID 7488077; See PMID 11036684; See PMID 1605639
An13g01860	Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An13g01870	Title: similarity to hypothetical protein encoded by An04g06980 - Aspergillus niger
An13g01880	Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: R. toruloides cephalosporin esterase is covered by patent WO9812345-A1 (AC# AAW54159).; Remark: the cephalosporin esterase from Rhodosporidium toruloides has EC 3. 1. 1. 41.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399; See PMID 10878123
An13g01890	Similarity: the predicted A. niger protein shows similarity to conserved hypothetical proteins from different microbial organisms.; Title: similarity to hypothetical protein Rv1147 -Mycobacterium tuberculosis
An13g01900	Title: weak similarity to hypothetical Kruppel-related gene 3 HKR3 - Homo sapiens
An13g01910	Remark: similarity is mainly due to serines and prolines in the protein.; Title: weak similarity to hypothetical pollen extensin-like protein Pex2 - Zea mays
An13g01920	Catalytic activity: acetyl-CoA C-acetyltransferase catalyzes the reversible reaction: acetoacetyl-CoA + CoA = 2 acetyl-CoA.; Function: acetyl-CoA C-acetyltransferase plays a major role in ketone body metabolism.; Remark: acetyl-CoA C-acetyltransferase is a tetramer of identical chains.; Title: strong similarity to precursor of acetyl-CoA C-acetyltransferase - Rattus norvegicus; localisation:mitochondrion; See PMID 2478525
An13g01930	Similarity: SSADH contains significant homology to bacterial NADP(+)-succinic semialdehyde dehydrogenase (EC 1. 2. 1. 16) and conserved regions of general aldehyde dehydrogenases (EC 1. 2. 1. 3), suggesting it is a member of the aldehyde dehydrogenase superfamily of proteins.; Title: strong similarity to succinate-semialdehyde dehydrogenase SSADH - Rattus norvegicus; See PMID 7814412
An13g01940	Catalytic activity: 3-Oxoadipate enol-lactone + H2O = 3-Oxoadipate.; Title: similarity to 3-oxoadipate enol-lactone hydrolase catD - Pseudomonas sp.; See PMID 11741863
An13g01960	Function: alkJ is membrane-bound and converts aliphatic medium-chain-length alcohols into aldehydes.; Remark: Pseudomonas putida was formerly annotated as Pseudomonas oleovorans.; Remark: alkJ is encoded on the plasmid OCT in the alkBFGHJKL operon.; Remark: the alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to metabolize alkanes.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas putida; plasma membrane; See PMID 1453953
An13g01980	Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae
An13g01990	Title: similarity to hypothetical protein encoded by An08g03120 - Aspergillus niger
An13g02000	Catalytic activity: catA catalyzes the oxygenative ring cleavage of catechol to form cis,cis-muconic acid.; Title: strong similarity to catechol 1,2-dioxygenase catA - Pseudomonas putida; See PMID 7646060
An13g02010	Remark: questionable due to small size and lack of homologies.; Title: questionable ORF
An13g02020	Title: strong similarity to hypothetical protein YCR010c - Saccharomyces cerevisiae
An13g02030	Function: GAP1 is the general amino acid permease gene of S. cerevisiae that catalyses active transport of apparently all biological amino acids across the plasma membrane.; Induction: GAP1 activity is regulated according to nitrogen source, the activity being high on urea and low on glutamate; this regulation is due to differential protein sorting from the Golgi complex to either the plasma membrane or the vacuole.; Phenotype: mutations at the GAP1 locus selectively abolish the activity of the general amino acid transport system.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane
An13g02040	Title: weak similarity to GAL4 DNA binding domain from patent WO9633724-A2 - Homo sapiens
An13g02050	Title: similarity to MmcH encoded protein sequence from patent WO200053737-A2 - Streptomyces lavendulae
An13g02060	Function: Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis.; Phenotype: disruption of Tri4 results in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the Tri4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An13g02070	Title: similarity to hypothetical protein MUK11 -Arabidopsis thaliana
An13g02080	Catalytic activity: 5-oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: 5-oxoprolinase is composed of two strongly interacting, apparently identical subunits.; Remark: evolutionary relationships exist among the hydantoinases and rat kidney 5-oxoprolinase which share the common property of hydrolyzing the imide bond of 5-membered rings.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290
An13g02090	Repression: allantoate uptake by DAL5 is constitutive but is sensitive to nitrogen catabolite repression.; Similarity: DAL5 is a member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3301804; See PMID 3549700
An13g02100	Title: weak similarity to transcription factor Cat8 - Kluyveromyces lactis
An13g02110	Catalytic activity: an alpha-L-fucoside + H(2)O = an alcohol + L-fucose.; Function: alpha-l-fucosidase FUCA1 is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n-acetylglucosamine of the carbohydrate moieties of glycoproteins.; Localization: FUCA1 has a lysosomal localization.; Remark: an unusual aspect of rat liver alpha-L-fucosidase FUCA1 protein structure is its high content of tryptophan (6%).; Similarity: FUCA1 belongs to family 29 of glycosyl hydrolases.; Title: strong similarity to tissue alpha-L-fucosidase precursor FUCA1 - Rattus norvegicus; lysosome; See PMID 2482732
An13g02120	Remark: C-terminally truncated due to contig border.; Title: similarity to hypothetical protein CAD37048.1 - Neurospora crassa [truncated ORF]
An13g02130	Catalytic activity: YPS3 of S. cerevisiae is a protease with endoproteolitic specificity for basic residue cleavage sites.; Localization: as its close homolgues YPS1 and YPS2,YPS3 of S. cerevisiae contain a C-terminal GPI-anchoring signal, and is probably bound to the plasma membrane.; Remark: YPS3 of S. cerevisiae is also called YPS4 or YLR121C.; Similarity: YPS3 of S. cerevisiae belongs to the yapsin group of enzymes, a subfamily of aspartic proteases; other yeast genes, as well as the mammalian pro-opiomelanocortin converting enzyme belong to this group.; Title: strong similarity to aspartic proteinase Yps3 - Saccharomyces cerevisiae; See PMID 10191273
An13g02140	Function: mal 23-c of S. cerevisiae is part of the complex locus MAL2, involved in the regulation of maltose utilization; Remark: the fungal Zn N-terminus domain forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues.; Similarity: in the N-terminal part of the predicted ORF there is a very well conserved fungal transcriptional regulatory protein Zn N-terminus domain, a Cys rich motif that is involved in zinc-dependent binding of DNA.; Similarity: the main feature of the predicted ORF is that it shows short regions of strong similarity with several proteins, all corresponding to well defined domains.; Title: similarity to MAL-activator 23-C Mal23-c -Saccharomyces cerevisiae; See PMID 3036644
An13g02150	Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8987357; See PMID 11065353
An13g02160	Catalytic activity: a carboxylic ester + H2O = an alcohol + a carboxylate.; Function: PNBA of B. subtilis catalyzes hydrolysis of several beta-lactam antibiotic p-nitrobenzyl (PNB) esters to the corresponding free acid and PNB alcohol, a process that can be important in the manufacturing of clinically important oral drugs.; Function: carboxylesterases show wide specificity.; Function: in humans, carboxylesterases play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs.; Similarity: PNBA of B. subtilis has high homology to members of carboxylesterase type B superfamily.; Similarity: the predicted ORF shows strong similarity to bacterial esterase (BEST1), patentnummer WO9902703-A1, which can be useful for the degradation and detoxification of fumonisins, which are toxic and potentially widespread in food and feed.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; See PMID 9597156
An13g02170	Similarity: the predicted ORF shows a partial weak similarity to a region of the 1,3-beta-glucanase of L. esculentum (tomato).
An13g02180	Catalytic activity: CFL1 of C. albicans, as well as the S. cerevisiae homologue FRE1, can reduce copper (Cu2+ to Cu+) besides iron.; Catalytic activity: NADH + 2 Fe(3+) = NAD(+) + 2 Fe(2+); Function: CFL1 of C. albicans can functionally rescue the S. cerevisiae fre1 mutants, lacking the ferric reductase activity.; Function: ferric reductase in C. albicans and other yeasts is used to reduce iron extracellularly and then specifically transport the ferrous iron into the cell.; Induction: C. albicans reductase activity is induced in low-iron conditions, and upon exit of stationary growth phase.; Localization: FRE1 of S. cerevisiae, the homologue of CFL1 of C. albicans, is an integral membrane protein.; Repression: C. albicans reductase activity is negatively regulated by copper.; Title: strong similarity to ferric reductase CFL1 -Candida albicans; See PMID 8868423; See PMID 10784045
An13g02210	Similarity: the predicted ORF has partial weak similarity to the replication protein-binding trans-activator RBT1 of M. musculus.
An13g02220	Title: similarity to hypothetical protein encoded by An19g00010 - Aspergillus niger
An13g02230	Title: strong similarity to EST AN04C06 -Aspergillus niger
An13g02240	Function: HOL1 of S. cerevisiae seems to be involved in the uptake of several cations and of histidinol.; Phenotype: gain-of-function HOL1 mutations in S. cerevisiae confer increased uptake rates of cations (including K+ and Na+) and histidinol; these mutations provoke amino-acid substitutions within the predicted transmembrane domains.; Similarity: HOL1 of S. cerevisiae belongs to the major facilitator family (also known as the multidrug resistance translocase family) of transport proteins.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 2405251
An13g02250	Title: similarity to hypothetical protein SC1C3.21 SC1C3.21 - Streptomyces coelicolor
An13g02260	Function: glutaryl 7-ACA acylase deacetylates 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Localization: extracellular excretion of glutaryl 7-ACA acylase was observed in a recombinant strain of B. subtilis.; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 1744041
An13g02270	Function: actVII is a dehydrase and forms part of the polyketide synthase for the antibiotic actinorhodin,which consists of discrete monofunctional components.; Title: similarity to dehydrase actVII - Streptomyces coelicolor; See PMID 1527048
An13g02280	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An13g02290	Function: N. crassa qa-4 catalyzes the third step of the quinic acid (qa) catabolic pathway.; Function: in N. crassa five structural and two regulatory genes mediate the initial events in quinate/shikimate metabolism as a carbon source.; Induction: N. crassa qa-4 is induced by quinic acid.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 2525625; See PMID 6241580
An13g02300	Similarity: the predicted A. niger ORF contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding motif.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194
An13g02310	Catalytic activity: Ribitol dehydrogenases convert Ribitol + NAD(+) to D-ribulose + NADH.; Function: K. aerogenes rbtD is required for the utilisation of ribitol as a carbon source.; Title: strong similarity to Ribitol dehydrogenase rbtD - Klebsiella aerogenes; See PMID 2933028
An13g02320	Function: A. thaliana mrp2 is a MgATP-energized pump active in the transport of glutathione (GS) and glucuronate conjugates and other bulky amphipathic anions across the vacuolar membrane.; Localization: A. thaliana mrp2 localizes to the vacuolar membrane fraction.; Remark: ORF 5'truncated due to end of contig.; Similarity: A. thaliana mrp2 is an ATP-binding cassette (ABC) transporter of the multidrug resistance-associated protein (MRP) family.; Title: strong similarity to glutathione S-conjugate ABC-transporter MRP2 - Arabidopsis thaliana [truncated ORF]; vacuole; See PMID 9693718; See PMID 11115509
An13g02330	Function: ATP-dependent transport of bile acids is a key determinant of bile flow in mammalian liver and is associated with cholesterol excretion, gallstone formation,and numerous inherited and acquired hepatobiliary diseases.; Remark: C-terminal truncated ORF due to end of contig.; Remark: the systematic name for YBT1 of S. cerevisiae is YLL048c.; Similarity: the ORF shows similarity to various multidrug resistance proteins, which are also active in ATP-dependent substrate transport.; Similarity: the aligment is over the C-terminal part of the predicted ORF, containing putative transmembrane stretches, but not a ATP-binding domain.; Title: similarity to membrane protein Ybt1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 8139928; See PMID 9182565
An13g02340	Similarity: similarity to human breast tumour-associated protein 77 patent DE19813839-A1.; Similarity: to dehydrogenases with different specificities.; Title: similarity to tumour-associated protein 77 from patent DE19813839-A1 - Homo sapiens
An13g02350	Remark: the N-terminal part of the protein shows similarity to unknown transport proteins with an aquaporin domain.; Remark: the similarity is only in the C-terminal part of the protein and shows in this part similarity to apuaporins.; Similarity: belongs to the major intrinsic protein family.; Title: similarity to aquaporin 3 AQP3 - Homo sapiens; See PMID 7558005
An13g02360	Title: weak similarity to ankyrin 1 Ank-1 - Mus musculus
An13g02370	Remark: probable zinc-finger protein.; Title: strong similarity to hypothetical protein EAA72710.1 - Gibberella zeae
An13g02380	Title: weak similarity to hypothetical NADH dehydrogenase subunit 2 ND2 - Lophognathus longirostris
An13g02390	Remark: also similarity to Neisseria gonorrheae ORF 097 patent WO9957280-A2.; Remark: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid,thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An13g02400	Remark: nirA mediates pathway-specific nitrate assimilation in Aspergillus nidulans.; Remark: the ORF is about 200 amino acids shorter than nirA of A. nidulans.; Similarity: to unassigned GAL4-type zinc cluster proteins.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1756977; See PMID 1922075
An13g02410	Title: weak similarity to hypothetical cation transporter DRA0361 - Deinococcus radiodurans
An13g02420	Title: strong similarity to hypothetical protein EAA54802.1 - Magnaporthe grisea
An13g02430	Remark: PKS1 is a multifunctional polyketide synthase (PKS) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: PKS1 is involved in production of the virulence factor T-toxin.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Similarity: shows also strong similarity to polyketide synthases of different organisms.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; See PMID 7500937
An13g02450	Title: strong similarity to hypothetical protein AAO76127.1 - Bacteroides thetaiotaomicron
An13g02460	Similarity: to nonribosomal peptide synthetases and polyketide synthetases.; Title: similarity to nonribosomal peptide synthase MxcG - Stigmatella aurantiaca; See PMID 11029592
An13g02480	Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: polyamine oxidase catalyses the oxidation of the secondary amino group of spermine, spermidine and their acetyl derivatives. The enzyme plays an important role in the regulation of polyamine intracellular concentration and is a member of the family of flavin-containing amine oxidases.; Similarity: belongs to amine oxidase (flavin-containing) proteins.; Title: strong similarity to polyamine oxidase PAO -Zea mays; See PMID 9598979; See PMID 10089528
An13g02510	Remark: members of the genus Aspergillus are opportunistic pathogens for cold- and warm-blooded animals. They are associated with an impressive spectrum of diseases in humans, ranging from benign colonization of the lung to life-threatening diseases such as invasive aspergillosis or allergic bronchopulmonary aspergillosis (ABPA).; Remark: rAsp f 9 Aspergillus fumigatus is one of those allergens. It shows similarity to various bacterial beta-glucanases and eukaryotic endotransglycosidases.; Title: strong similarity to allergen rAsp f 9 -Aspergillus fumigatus; See PMID 9482698
An13g02530	Catalytic activity: H2CO3 = CO2 + H2O.; Pathway: nitrogen metabolism.; Remark: most of the N. gonorrhoeae CAH seems to be produced as a soluble protein located in the periplasm of E. coli. The enzyme is homologous to carbonic anhydrases from the animal kingdom; it is an alpha-carbonic anhydrase. A comparison with the amino acid sequences of human carbonic anhydrases I and II suggests that the secondary structures are essentially intact in the bacterial enzyme but that several loops are much shorter than in the human forms.; Similarity: belongs to the carbonic anhydrase family.; Title: similarity to carbonic anhydrase CAH -Neisseria gonorrhoeae; See PMID 9108244; See PMID 9761692; See PMID 11248679
An13g02540	Remark: alternative names are GTT1, YIR038c.; Remark: subcellular fractionation demonstrated that Gtt1p associates with the endoplasmic reticulum. Expression of GTT1 is induced after diauxic shift and remains high throughout the stationary phase.; Remark: the glutathione S-transferases (GSTs) represent a significant group of detoxification enzymes that play an important role in drug resistance in all eukaryotic species.; Title: strong similarity to glutathione S-transferase Gtt1 - Saccharomyces cerevisiae; See PMID 9792709
An13g02570	Title: weak similarity to hypothetical protein encoded by An14g02770 - Aspergillus niger
An13g02590	Function: low-affinity glucose transporter. Can function as a sensor that generates an intracellular signal in the presence of high level of glucose. Required for maximal expression of the high glucose-induced hxt1 protein.; Remark: Rgt2p is a high glucose-sensing counterpart to Snf3p.; Remark: alternative name is YDL138w.; Similarity: belongs to the sugar transporter family.; Title: similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; See PMID 8901598
An13g02600	Remark: all other found dioxygenases are exept the YLL057c 100 amino acids shorter.; Remark: purified recombinant yeast protein YLL057c is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase.; Similarity: belongs to the tfda family of dioxygenases.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942
An13g02610	Title: similarity to hypothetical protein EAA77948.1 - Gibberella zeae
An13g02620	Remark: also strong similarity to S. lividans proteinase (slpE).; Remark: impaired expression of such proteases by Streptomyces hosts improves the quality, quantity and stability of exogenous gene products.; Remark: strong similarity to S. lividans protease P5-6 patent WO9517512-A.; Title: strong similarity to proteinase P5-6 from patent WO9517512-A - Streptomyces lividans; See PMID 7592364
An13g02640	Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Pathway: tyrosine metabolism; phenylalanine metabolism; nitrogen metabolism; alkaloid biosynthesis II.; Remark: PAL is used for the prodn. of L-phenylalanine from cinnamic acid and ammonia.; Remark: also strong similarity to L-phenylalanine ammonia lyase (PAL) from Rhodosporidium turoloides patent EP278706-A.; Remark: the active sites of the enzyme phenylalanine ammonia-lyase (Pal) from Rhodosporidium toruloides contains a dehydroalanine residue that is believed to be essential for catalytic activity.; Similarity: belongs to the histidine ammonia-lyase family.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides; See PMID 8200528; See PMID 1368015
An13g02660	Title: weak similarity to hypothetical N-WASP binding protein WISH - Mus musculus
An13g02670	Gene-ID: Arsa-7; Remark: Arsa-7 from A. niger is differentially expressed in the pellet morphology relative to the filamentous morphology.; Remark: putative cell wall protein.
An13g02680	Remark: Inactivation of ribonucleotide reductase, by either hydroxyurea or a cdc22-M45 mutation, causes liz1(-) cells in G2 to undergo an aberrant mitosis, resulting in chromosome missegregation and late mitotic arrest.; Remark: Liz1p, a fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; See PMID 9950674
An13g02690	Catalytic activity: N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.; Function: this protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.; Remark: pulmonary microsomes from Rhesus macaque express a flavin-containing monooxygenase (FMO) resembling the FMO2 ortholog from rabbit with respect to immunochemical cross-reactivity and expression in lung, but not liver.; Similarity: belongs to the FMO family.; Title: strong similarity to flavin-containing monooxygenase FMO2 - Macaca mulatta; See PMID 9061021
An13g02700	Catalytic activity: taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.; EC:1.14.11.17.; Remark: taurine/alpha-ketoglutarate dioxygenase (TauD), a member of the broad class of non-heme Fe(II) oxygenases, converts taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde while decomposing alpha-ketoglutarate (alphaKG) to form succinate and CO(2).; Remark: the Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Similarity: belongs to the TFDA family.; Title: similarity to taurine dioxygenase,2-oxoglutarate-dependent tauD - Escherichia coli; See PMID 9287300; See PMID 10563813
An13g02710	Title: weak similarity to hypothetical protein YIL064w - Saccharomyces cerevisiae
An13g02720	Title: weak similarity to hypothetical urokinase plasminogen activator receptor UPAR - Aotus trivirgatus
An13g02730	Remark: the ORF is putative 5' longer.; Title: strong similarity to EST an_3461 -Aspergillus niger
An13g02770	Remark: D(--)-Mandelate dehydrogenase, the first enzyme of the mandelate pathway in the yeast Rhodotorula graminis, catalyses the NAD(+)-dependent oxidation of D(--)-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase - Rhodotorula graminis; See PMID 8411179; See PMID 1731758
An13g02780	Remark: ADD is a cytoskeletal heterodimeric protein which may be involved in cellular signal transduction and interacts with other membrane skeleton proteins which affect ion transport across the cell membrane.; Remark: in rat, mouse and human the adducins are playing a substantial role in hypertension.; Remark: the similarity of the ORF to proteins of higher organisms concerns the N-terminal region of adducins, however the ORF shows also homology to aldolases from lower eucaryotes over its whole lenght.; Title: similarity to alpha-adducin alpha-ADD -Rattus norvegicus; See PMID 8543181; See PMID 9678591
An13g02790	Remark: impaired expression of Tap by Streptomyces hosts improves the quality, quantity and stability of exogenous gene products.; Remark: strong similarity to S. lividans protease Tap patent WO9517512-A.; Remark: tripeptidyl aminopeptidase (Tap) from Streptomyces lividans is responsible for the major amino-terminal degradative activity in culture broths of S. lividans strains.; Title: strong similarity to tripeptidylaminopeptidase Tap - Streptomyces lividans; See PMID 7487044
An13g02810	Remark: ENB1 S. cerevisiae encodes a transporter protein (Enb1p), which specifically recognizes and transports enterobactin. Enterobactin is a catecholate-type siderophore produced by several enterobacterial genera grown in severe iron deprivation.; Similarity: belongs to the major facilitator super family (MFS).; Title: strong similarity to siderophore-iron transporter for enterobactin Enb1 - Saccharomyces cerevisiae; See PMID 10831226
An13g02820	Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; Diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: gehA, P. acnes was overexpressed in E. coli under the control of the bacteriophage T7 promoter, and the corresponding polypeptide was found to be present in insoluble aggregates. Active lipase was produced when the overexpressing strain was incubated at a reduced temperature in the presence of sucrose.; Similarity: belongs to the triacylglycerol lipase family.; Title: strong similarity to triacylglycerol lipase gehA - Propionibacterium acnes; See PMID 9168624
An13g02880	Title: strong similarity to hypothetical integral membrane protein SPAC16A10.01 - Schizosaccharomyces pombe
An13g02890	Remark: the predicted ORF is questionable due to its intron-exon structure and proximity to the next N-terminally encoded ORF.; Title: questionable ORF
An13g02920	Function: due to the restricted similarity to lovF of A. terreus it is assumed, that the predicted ORF encodes another, e. g. A. niger-specific polyketide synthase with an N-terminal beta-ketoacyl synthase domain containing an active site cysteine.; Remark: lovF polyketid synthase of A. terreus is encoded in a lovastatin biosynthesis cluster.; Remark: polyketid biosynthesis in bacteria and fungi is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Similarity: the predicted ORF is only 1/10 as long as lovF of A. terreus and its similarity to lovF is restricted to the 60 N-terminal amino acids.; Title: similarity to polyketide synthase lovF -Aspergillus terreus; See PMID 10334994; See PMID 10381407
An13g02940	Function: lovC of A. terreus is thought to be responsible for the three enoyl reductions predicted to be necessary for the formation of dihydromonacolin L, a intermediate of lovastatin production.; Remark: lovC of A. terreus is encoded in a lovastatin biosynthesis cluster, which also contains other proteins involved in polyketide synthesis, e. g. lovB and lovF.; Remark: lovC of A. terreus is involved in polyketide synthesis, that is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; See PMID 10381407
An13g02960	Function: lovB of A. terreus is involved in polyketide synthesis, that is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Remark: lovB of A. terreus is encoded in a lovastatin biosynthesis cluster, which also contains other proteins involved in polyketide synthesis, e. g. lovC and lovF.; Remark: the predicted ORF is C-terminally truncated due to the contig border.; Similarity: the predicted ORF shows comparable similarity to lovB and lovF of A. terreus, therefore it is assumed, that it may encode an A. niger-specific polyketide synthase.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [truncated ORF]; See PMID 10381407; See PMID 11378962
An13g02970	Title: weak similarity to hypothetical protein encoded by An08g03800 - Aspergillus niger
An13g02980	Title: similarity to hypothetical protein encoded by An01g08440 - Aspergillus niger
An13g02990	Similarity: the predicted ORF is rich in proline,glycine and glutamine, therefore it shows unspecific similarity to some proteins with a high content of these amino acids.; Title: similarity to hypothetical protein EAA71271.1 - Gibberella zeae
An13g03000	Catalytic activity: ALK1 of Y. lipolytica catalyses RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein.; Function: ALK1 of Y. lipolytica is probably the major cytochrome P450 protein to metabolize short-chain n-alkanes such as decane and dodecane in Y. lipolytica.; Induction: ALK1 of Y. lipolytica is induced by n-tetradecane and repressed by glycerol.; Phenotype: an ALK1 of Y. lipolytica gene disruptant did not grow well on n-decane, but grew on longer-chain n-alkanes such as hexadecane as a sole carbon source.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 9848230; See PMID 10953079
An13g03010	Remark: the intron-exon structure is not optimal.
An13g03020	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 86 amino acids long.; Title: questionable ORF
An13g03030	Title: similarity to hypothetical protein CAB91400.2 - Neurospora crassa [putative sequencing error]; putative sequencing error
An13g03040	Function: esyn1 of F. scirpi is a multifunctional enzyme catalysing n-methyl depsipeptide formation.; Similarity: esyn1 of F. scirpi is 3131 amino acids long and the predicted ORF 1415 aa.; Similarity: the ORF show similarity to several peptide synthetases from different species.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 7601090; See PMID 8483420
An13g03050	Title: weak similarity to hypothetical protein encoded by An04g04070 - Aspergillus niger
An13g03060	Induction: the transcription of atrB from A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; See PMID 9180695
An13g03080	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 77 amino acids long.; Title: questionable ORF
An13g03090	Remark: the ORF contains introns, that are suboptimal long.
An13g03100	Function: DUK1 of S. cerevisiae is a channel permeable to outward flow of K+ ions.; Remark: DUK1 of S. cerevisiae is also called TOK1,YJL093C, YKC1 or YORK.; Repression: in excised membrane patches external divalent cations block DUK1 of S. cerevisiae in a voltage-dependent manner, and their removal allows inward channel current.; Title: strong similarity to outward-rectifier potassium channel Duk1 - Saccharomyces cerevisiae; See PMID 10089235; See PMID 7651518
An13g03110	Function: TNA1 of S. cerevisiae is a high affinity plasma membrane permease, which belongs to the allantoate permease family and is involved in the uptake of nicotinic acid.; Phenotype: the deletion of TNA1 in S. cerevisiae prevents growth at low nicotinic acid concentration.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260W.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:AN784) Nig091.; Similarity: the ORF shows similarity to several transporters with different substrate specificities.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An13g03130	Similarity: the predicted ORF is 125 amino acids longer at the C-terminus than the putative cysteine-binding protein fliY of H. volcanii.; Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii
An13g03140	Remark: the EC number of endo-beta-1,4-glucanase is 3. 2. 1. 4.; Similarity: the homology is restricted to the N-terminal part of celA1 from S. halstedii.; Title: weak similarity to endo-beta-1,4-glucanase celA1 - Streptomyces halstedii; See PMID 1400190
An13g03150	Catalytic activity: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide +CO2.; Catalytic activity: the E1 component of BCKDH requires thiamin pyrophosphate as a cofactor.; Complex: the E1 component of BCKDH is composed of two alpha and two beta chains.; Function: the E1 component of BCKDH catalyses the oxidative decarboxylation of branched-chain alpha-ketoacids, which are derived from branched-chain amino acids by transamination.; Pathway: BCKDH is a key enzyme in the catabolism of branched-chain amino acids.; Title: strong similarity to Arp2/3 complex 34 kD subunit BCKDH - Gallus gallus; localisation:mitochondrion; See PMID 11168412
An13g03160	Function: astA of E. rectale catalyzes the transfer of a sulfate moiety from an aromatic sulfate ester to another aromatic alcohol.; Title: similarity to arylsulfate sulfotransferase astA - Eubacterium rectale IIIH; See PMID 11320417
An13g03190	Catalytic activity: Rnh1 of M. musculus cleaves RNA-DNA hybrids at the RNA:DNA junction generating a 3'-hydroxyl-terminated oligoribonucleotide and a 5'-monophosphate-terminated polydeoxyribonucleotide.; Function: a role of RNase H1 in the removal of RNA primers during lagging-strand DNA biosynthesis is proposed.; Title: strong similarity to ribonuclease (RNase) H1 Rnh1 - Mus musculus; nucleus; See PMID 9799596; See PMID 10567561
An13g03200	Remark: the ORF is short in length (85 amino acids).
An13g03220	Function: TPO1 of S. cerevisiae facilitates the uptake of the polyamines spermine and spermidine into vacuolar vesicles.; Function: TPO1 of S. cerevisiae is involved in the regulation of the spermidine and spermine content of the cytoplasm.; Remark: the systematic gene name of TPO1 in S. cerevisiae is YLL028w.; Similarity: belongs to the major facilitator superfamily (MFS-MDR).; Similarity: shows an even stronger similarity to a protein involved in cepahalosporin C biosynthesis of protein patent GENESEQPROT:W14440 which lacks a clear functional description.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 11171066
An13g03230	Title: similarity to hypothetical transcription regulator SPBC530.11c - Schizosaccharomyces pombe
An13g03240	Title: strong similarity to hypothetical protein Z of the rapamycin biosynthetis gene cluster - Streptomyces hygroscopicus; See PMID 8635730
An13g03250	Function: RAG1 of K. lactis facilitates the cellular uptake of various sugars including glucose and fructose.; Function: RAG1 of K. lactis is important for fermentative growth.; Induction: RAG1 of K. lactis is inducible by glucose, fructose, mannose, sucrose, raffinose and galactose.; Title: strong similarity to low affinity hexose transporter RAG1 - Kluyveromyces lactis; plasma membrane; See PMID 1603079; See PMID 2402460
An13g03260	Similarity: homologous to protein of patent database entry GENESEQPROT:B19189.; Title: strong similarity to lipid metabolism protein YGR046w from patent WO200058521-A2 - Saccharomyces cerevisiae
An13g03270	Title: similarity to hypothetical protein encoded by An13g03280 - Aspergillus niger
An13g03280	Title: similarity to hypothetical protein encoded by An13g03270 - Aspergillus niger
An13g03290	Title: strong similarity to hypothetical protein of the paxilline biosynthesis gene cluster paxU - Penicillium paxilli; See PMID 11169115
An13g03300	Title: strong similarity to hypothetical conserved protein 99H12.80 - Neurospora crassa
An13g03310	Remark: alternative name is YGR260w.; Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell. The direct measurement of nicotinic acid uptake on whole cells demonstrates that YGR260w encodes the yeast high affinity nicotinic acid permease.; Similarity: to Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An13g03320	Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Similarity: belongs to the thiamine-diphosphate protein family.; Title: strong similarity to pyruvate decarboxylase (PDC)-2 SEQ ID NO:44292 from patent EP1033405-A2 -Arabidopsis thaliana
An13g03330	Protein sequence is in conflict with the conceptual translation; Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; atty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: Expression of the structural genes for alcohol and aldehyde dehydrogenase, alcA and aldA,respectively, enables the fungus Aspergillus nidulans to grow on ethanol. The pathway-specific transcriptional activator AlcR mediates the induction of ethanol catabolism in the presence of a coinducing compound. Ethanol catabolism is further subject to negative control mediated by the general carbon catabolite repressor CreA.; Remark: putative sequencing error at position 33553 generating a frame shift. 1 bases too much.; Similarity: belongs to the long-chain alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase alcA - Aspergillus nidulans; putative frameshift; See PMID 3297923; See PMID 11102439
An13g03360	Title: strong similarity to hypothetical protein encoded by An12g09820 - Aspergillus niger
An13g03370	Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913
An13g03380	Remark: strong similarity to amino acid sequence of M. vaccae antigen GV-33 patent WO9932634-A2.; Title: strong similarity to amino acid sequence antigen GV-33 from patent WO9932634-A2 - Mycobacterium vaccae
An13g03400	Title: strong similarity to hypothetical protein encoded by An03g03680 - Aspergillus niger
An13g03430	Title: similarity to hypothetical protein encoded by An15g04190 - Aspergillus niger
An13g03440	Title: similarity to hypothetical protein NMA2036 -Neisseria meningitidis
An13g03450	Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea
An13g03470	Remark: similarity to bacterial Flavin monooxygenase fccC amino acid sequence SEQ ID NO:7. patent WO200004158-A2.; Remark: the prdicted ORF seems N-terminal approximately 150 aa to long.; Title: similarity to flavin monooxygenase fccC from patent WO200004158-A2 - Bacterium 2412.1
An13g03480	Remark: all found homolog proteins differ in size.; Title: weak similarity to tonoplast intrinsic protein ZmTIP1 - Zea mays
An13g03490	Remark: the 1. 8 A crystal structure of E. coli ycaCgp reveals an octameric complex comprised of two tetrameric rings. A large three-layer (alphabetaalpha) sandwich domain and a small helical domain form the folded structure of the monomeric unit. Comparisons with sequence and structure databases suggest that ycaCgp belongs to a diverse family of bacterial hydrolases. The most closely related three-dimensional structure is that of the D2 tetrameric N-carbamoylsarcosine amidohydrolase (CSHase) from an Arthrobacter species.; Title: strong similarity to hydrolase of unknown specificity ycaC - Escherichia coli; See PMID 9782055
An13g03500	Remark: human ARSDR1 is involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the pathogenesis of prostate carcinoma.; Remark: the patent sequence is nearly the same as the human androgen-regulated short-chain dehydrogenase/reductase 1 except the 4 N-terminal amino acids.; Similarity: belongs to the short-chain alcohol dehydrogenases.; Title: strong similarity to sequence 1 from patent WO0065067-A - Homo sapiens; See PMID 11245473
An13g03510	Remark: the predicted ORF could encode, together with ORF 110CG, another part of the Ant1 transposon (lenght: 4918 nt), as the sequence 3' to this region is probably the transposase, which is decribed to lie 3' of the Ant1 transposon 5' insertion site (niaD insertion site).
An13g03520	Remark: the predicted ORF could encode, together with ORF 118WK, another part of the Ant1 transposon (lenght: 4918 nt), as the sequence 3' to this region is probably the transposase, which is decribed to lie 3' of the Ant1 transposon 5' insertion site (niaD insertion site).; Title: strong similarity to hypothetical protein encoded by An05g02110 - Aspergillus niger
An13g03530	Function: ORF1 of transposon Ant1 from A. niger encodes a putative Tc1-mariner class transposase.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048
An13g03540	Title: similarity to hypothetical protein encoded by An04g03850 - Aspergillus niger
An13g03550	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: due to the presence of WD-40 repeats, the ORF shows similarity to several proteins, that contain this motif.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the ORF is much shorter than het-e-1 of P. anserina (380 amino acids compaired to 1356), and shows no similarity to the GTP-binding domain of the vegetative incompatibility protein.; Title: strong similarity to vegetative incompatibility protein het-e1 - Podospora anserina; See PMID 10875280; See PMID 10974123; See PMID 7557402; See PMID 9435787
An13g03560	Function: MAOB of H. sapiens plays an important role in regulating the intracellular levels of amines via there oxidation, e. g. it catalyzes the oxidative deamination of many neuro-transmitters and dietary amines.; Title: strong similarity to flavin-containing amine oxidase MAOB - Homo sapiens
An13g03570	Similarity: the ORF shows strong similarity to ABC transporters/multidrug resistance proteins with various substrate specificities.; Title: strong similarity to ABC transporter CDR4 -Candida albicans; See PMID 9767132
An13g03590	Similarity: the ORF shows similarity to several putative transcrption regulators.; Title: similarity to fungal ZBC protein sequence #41 from patent WO200224865-A2 - unidentified organism
An13g03600	Catalytic activity: PLCN of B. pseudomallei converts phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Function: PLCN of B. pseudomallei hydrolyses phosphatidylserine and phosphatidylcholine.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE758821) an_3066.; Similarity: the predicted ORF is 225 amino acids shorter at its C-terminus than PLCN of B. pseudomallei.; Title: strong similarity to phosphatidylcholine-hydrolyzing phospholipase C PLCN -Burkholderia pseudomallei
An13g03610	Function: FLU1 of C. albicans is a multidrug efflux transporter of the major facilitator superfamily, which confers resistance to fluconazole and to cycloheximide.; Phenotype: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid, thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Similarity: the ORF shows strong similarity to various multidrug efflux transporters with different substrate specificities.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans
An13g03640	Function: polyamine transport proteins in the vacuolar membrane regulate the polyamine content in the cytoplasm.; Similarity: the ORF is 97 amino acids shorter at the N-terminus than TPO1 of S. cerevisiae.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 11171066; See PMID 9920864; See PMID 10585849
An13g03650	Function: high-affinity permease for lysine; Similarity: belongs to a family that groups many amino acid permeases; Title: strong similarity to lysine permease Lyp1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8368011
An13g03660	Title: weak similarity to hypothetical protein encoded by An12g09260 - Aspergillus niger
An13g03670	Remark: C-terminally truncated ORF due to contig end.; Title: questionable ORF [truncated ORF]
An13g03680	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3275614
An13g03690	Title: strong similarity to hypothetical protein EAA59596.1 - Aspergillus nidulans
An13g03710	Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: the substrate specificity of the SAM1606 alpha-glucosidase was significantly different from those of the oligo-1,6-glucosidases.; Similarity: belongs to the alpha-glucosidases.; Title: strong similarity to alpha-glucosidase aglU -Bacillus sp.; See PMID 8125087
An13g03730	Catalytic activity: acetyl-CoA + beta-D-Galactoside = CoA + 6-acetyl-beta-D-galactoside.; Remark: Escherichia coli galactoside acetyltransferase (GAT) is a member of a large family of acetyltransferases that O-acetylate dissimilar substrates but share limited sequence homology. Steady-state kinetic analysis of over-expressed GAT demonstrated that it accepted a range of substrates, including glucosides and lactosides which were acetylated at rates comparable to galactosides.; Remark: the ORF is C-terminal shorter than the matching sequences, probably due to an previous transposon insertion.; Similarity: belongs to the acetyltransferases (the isoleucine patch superfamily).; Title: similarity to galactoside acetyltransferase lacA - Escherichia coli; See PMID 7592843
An13g03740	Title: weak similarity to hypothetical retrovirus-related polyprotein - Arabidopsis thaliana
An13g03760	Title: similarity to hypothetical protein encoded by An02g09120 - Aspergillus niger
An13g03790	Remark: strong similarity to Candida albicans polypeptide sequence # 24 patent EP982401-A2.; Similarity: belongs to the acetyltransferases (the isoleucine patch superfamily).; Title: strong similarity to polypeptide sequence # 24 from patent EP982401-A2 - Candida albicans
An13g03800	Remark: strong similarity to bacterial esterase (BEST1) WO9606175-A2 and WO9902703-A1.; Remark: the esterase enzyme can degrade fumonisin. The polynucleotides encoding fumonisin degrading enzymes are useful for degrading fumonisins during the process of harvesting grain for animal feed, or in plant tissues,which are used for silage or as a spray on grain, fruit or vegetables. They are also useful for detoxifying fumonisins, structurally related mycotoxins, and fumonisin hydrolysis products of both.; Title: strong similarity to fumonisin esterase BEST1 from patent WO9606175-A2 - Bacterium ATCC 55552
An13g03810	Catalytic activity: digallate + H2O = 2 gallate.; Remark: also hydrolyses ester links in other tannins.; Remark: strong similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769
An13g03820	Remark: the CZF1 gene, encoding a putative transcription factor, was shown to be involved in the regulation of hyphal growth under certain conditions,including embedded conditions. Ectopic expression of CZF1 in embedded cells promoted the rapid formation of hyphae. Elimination of CZF1 and CPH1, encoding a homologue of the S. cerevisiae Ste12p transcription factor, led to a pronounced defect in filamentous growth of embedded cells.; Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to zinc-finger protein CZF1 -Candida albicans; See PMID 10564506; See PMID 1409649
An13g03860	Title: strong similarity to hypothetical protein encoded by An08g09040 - Aspergillus niger
An13g03870	Remark: genetic analysis and GFP fusions show that the NLS of a Zn-binuclear cluster transcriptional activator of Aspergillus nidulans (PrnA) is tripartite.; Remark: the prnA gene A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360; See PMID 10788322
An13g03890	Similarity: to multidrug-efflux transporters.; Title: strong similarity to hypothetical protein B15I20.50 - Neurospora crassa
An13g03910	Function: PYD2 enables Saccharomyces kluyveri to degrade the majority of pyrimidines.; Induction: PYD2 expression is inducible by dihydrouracil, though not by uracil.; Similarity: PYD2 shows similarities with dihydroorotases, allantoinases and uricases from various organisms.; Title: strong similarity to dihydropyrimidinase Pyd2 - Saccharomyces kluyveri; See PMID 10656811
An13g03920	Remark: this enzyme has strict specificity for the D-form and strict substrate specificity for N-carbamyl-D-amino acids, but does not react with N-carbamyl-beta-alanine.; Title: similarity to N-carbamyl-D-amino acid amidohydrolase - Pseudomonas sp.; See PMID 9648218
An13g03930	Function: DAL4 is responsible for the transport of allantoin into the cell.; Phenotype: DAL4 mutants are unable to transport allantoin and exhibit a 50% loss of allantoate transport.; Similarity: there is a striking similarity of DAL4 to the uracil permease component encoded by FUR4.; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; plasma membrane; See PMID 1293888; See PMID 3549700
An13g03940	Function: LCAD is involved in the utilization of fatty acids for energy generation.; Title: strong similarity to long-chain-acyl-CoA dehydrogenase precursor LCAD - Rattus norvegicus; localisation:mitochondrion; See PMID 8268228; See PMID 2777793
An13g03950	Title: strong similarity to hypothetical protein EAA59522.1 - Aspergillus nidulans
An13g03970	Catalytic activity: FAD of M. marinus catalyzes the reaction of formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH.; Remark: the ORF encoded protein also shows similarity to other dehydrogenases.; Similarity: FAD of M. marinus belongs to the zinc-containing alcohol dehydrogenase family. class-III subfamily.; Title: similarity to glutathione-dependent formaldehyde dehydrogenase FDH - Methylobacter marinus; See PMID 7926692
An13g03980	Phenotype: disruption of flavanone 3 beta-hydroxylase in Petunia hybrida causes white flowers.; Remark: the ORF encoded protein also shows similarity to other oxidoreductase.; Similarity: 3 beta-hydroxylase of Petunia hybrida belongs to the 1-aminocyclopropane-1-carboxylate oxidase family.; Title: similarity to flavanone 3 beta-hydroxylase -Petunia hybrida; See PMID 1544919; See PMID 2154946
An13g03990	Function: FUI1 of S. cerevisiae is required for the high-affinity transport of uridine.; Remark: YBL042C and YBL040 are alternative names for FUI1 of S. cerevisiae.; Remark: the ORF encoded protein also shows strong similarity to allantoin permeases.; Similarity: FUI1 of S. cerevisiae belongs to the allantoin permease family.; Title: strong similarity to uridine permease Fui1 -Saccharomyces cerevisiae; plasma membrane; See PMID 9485596
An13g04000	Catalytic activity: hmgA of S. solfaticus catalyzes the reaction of (S)-mevalonate + CoA + 2 NADP+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: hmgA of S. solfaticus converts HMG-CoA to mevalonate.; Similarity: hmgA of S. solfaticus belongs to the HMG-CoA reductase family.; Title: strong similarity to hydroxymethylglutaryl-CoA reductase hmgA - Sulfolobus solfataricus; See PMID 9171410
An13g04010	Title: similarity to hypothetical protein encoded by An13g04050 - Aspergillus niger
An13g04030	Title: similarity to hypothetical protein B11A5.10 -Neurospora crassa
An13g04050	Title: similarity to hypothetical protein encoded by An13g04010 - Aspergillus niger
An13g04060	Title: strong similarity to hypothetical protein encoded by An07g08820 - Aspergillus niger
An13g04070	Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism
An13g04080	Remark: this P450 of G. fujikuroi is, together with three similar P450 monooxygenases, a putative geranylgeranyl diphosphate synthase, and a copalyl diphosphate synthase, involved in gibberellin biosynthesis.; Title: strong similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 9917370; See PMID 10531641
An12g00010	Remark: questionable ORF due to the absence of an intron-exon structure.; Title: questionable ORF
An12g00020	Function: lactate dehydrogenases catalyse the oxidation of lactate to pyruvate.; Remark: the predicted ORF shows homology to A. nidulans EST AA966896.; Similarity: the predicted ORF shows similarity to some lactate dehydrogenases from several species.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis
An12g00030	Catalytic activity: L-iditol 2-dehydrogenases catalyze L-sorbitol + NAD(+) = L-sorbose + NADH.; Function: L-iditol 2-dehydrogenases catalyze the oxidation by NAD+ of sorbitol to fructose.; Remark: the predicted ORF shows partial similarity to A. nidulans ESTs AA785306 and AA966892.; Title: strong similarity to L-iditol 2-dehydrogenase Sor1 - Saccharomyces cerevisiae; See PMID 8125328; See PMID 9464424
An12g00040	Function: rab4 is involved in intracellular trafficking of proteins and might play a role in transport arrest during mitosis.; Remark: human rab4 is phoshorylated by cdc2-kinase during mitosis.; Title: strong similarity to GTP-binding protein rab4 - Homo sapiens; intracellular transport vesicles; See PMID 8330623; See PMID 1902553; See PMID 2501306
An12g00060	Title: similarity to hypothetical protein CAE76586.1 - Neurospora crassa
An12g00080	Remark: questionable ORF due to the presence of only 55 amino acids coding sequence.; Title: questionable ORF
An12g00100	Similarity: the N-terminal part of the predicted ORF shows weak similarities to polysaccharide synthesizing proteins of fungi and plants, that are supposed to be involved in cell wall biogenesis.; Similarity: the predicted ORF shows similarities to A. nidulans EST AA784284.; Title: strong similarity to hypothetical polysaccharide synthase CPS1 - Filobasidiella neoformans
An12g00110	Function: atp12 of S. cerevisiae is required for the assembly of the mitochondrial F1-F0 complex.; Localization: atp12 of S. cerevisiae is located in the mitochondrial matrix.; Similarity: the first 40 amino acids of atp12 from S. cerevisiae, which are probably necessary for mitochondrial localization, show no homology to the predicted ORF.; Title: strong similarity to F1-F0 complex assembling factor Atp12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1826907; See PMID 2142305
An12g00120	Function: swh1 of S. cerevisiae plays a role in ergosterol synthesis.; Function: the seven homologues of the mammalian oxysterol-binding protein (OSBP) in S. cerevisiae are implicated in lipid trafficking and sterol homeostasis.; Remark: swh1 is also called osh1 or YAR044W.; Similarity: the predicted ORF shares homologies with the A. nidulans EST AA788412.; Title: strong similarity to hypothetical oxysterol binding protein homologue Swh1 - Saccharomyces cerevisiae; See PMID 11238399
An12g00130	Function: the mss51 protein of S. cerevisiae is required for the maturation and translation of cytochrome c oxidase subunit I mRNA.; Phenotype: the mss51 mutant of S. cerevisiae is respiratory deficient due to the absence of cytochrome c oxidase subunit 1 (Cox1p).; Similarity: the predicted ORF is identical to the first 42 nucleotides of A. niger EST ANI239933.; Title: strong similarity to mRNA processing protein of cytochrome c oxidase Mss51 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6320175; See PMID 10803883; See PMID 2177521; See PMID 6297789
An12g00140	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An12g00150	Remark: questionable ORF due to the presence of unusally long introns.; Title: questionable ORF
An12g00160	Catalytic activity: mae1 of S. cerevisiae (oxaloacetate decarboxylating) catalyses the oxidative decarboxylation of malate to pyruvate (S)-malate + NAD(+) <=> pyruvate + CO2 + NADH.; Function: mae1 of S. cerevisiae is involved in the synthesis of pyruvate by facilitating an alternative route for pyruvate synthesis, that is not dependent on the activity of pyruvate kinase.; Induction: a three to fourfold induction of mae1 from S. cerevisiae was observed during anaerobic growth on glucose.; Phenotype: the null mutant of S. cerevisiae exhibits no malic enzyme activity.; Title: strong similarity to malate dehydrogenase homolog Mae1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9062925; See PMID 9603875
An12g00170	Catalytic activity: quinone reductases catalyse NADPH + quinone = NADP(+) + semiquinone.; Function: quinone reductases catalyse the one electron reduction of certain quinones.; Title: strong similarity to quinone reductase cryz -Cavia porcellus; See PMID 9426193; See PMID 1989495
An12g00190	Remark: questionable ORF due to unusal exon-intron structure.; Title: questionable ORF
An12g00200	Remark: questionable ORF due to the presence of an unusal exon-intro structure.; Title: questionable ORF
An12g00210	Function: snf2 of H. sapiens as part of the swi/snf complex is involved in reorganization of chromatin structure to facilitate binding of transcription factors.; Function: the human swi/snf complex mediates the ATP-dependent disruption of a nucleosome, thereby enabling the activators, gal4-vp16 and gal4-ah, to bind within a nucleosome core.; Remark: the predicted ORF is 100 amino acids longer at the N-terminus than human snf2.; Similarity: the predicted ORF shows similarities with several snf proteins from different species starting around amino acid 800 of the predicted ORF.; Title: strong similarity to transcription activator snf2 - Homo sapiens; nucleus; See PMID 8047169; See PMID 9099865
An12g00220	Similarity: the predicted ORF overlaps with A. niger EST BE759492.; Similarity: the predicted ORF shares weak similarities with one chain of human and bovine NADH dehydrogenase.; Title: strong similarity to hypothetical protein EAA61911.1 - Aspergillus nidulans
An12g00230	Title: strong similarity to hypothetical protein B14D6.520 - Neurospora crassa
An12g00240	Function: a member of the yer057c/yjgf/upf0076/uk114 family, the yabJ gene from B. subtilis is required for adenine-mediated repression of purine biosynthetic genes.; Function: human recombinant uk14 (p14. 5) inhibits in vitro protein synthesis in a rabbit reticulocyte lysate system.; Induction: the uk14 mRNA of H. sapiens is weakly expressed in freshly isolated monocytes, but is significantly upregulated when these monocytes are subjected to differentiation.; Remark: the ORF is N-terminally truncated due to 3' contig boder.; Remark: uk14 belongs to the new hypothetical family of small proteins with presently unknown function, named yer057c/yjgf/upf0076/uk114 family.; Title: strong similarity to translational inhibitor uk14 - Homo sapiens [truncated ORF]; See PMID 8973653
An12g00250	Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: weak similarity to precursor of antiplatelet protein - Haementeria officinalis [truncated ORF]
An12g00260	Remark: blastp homologies may be due to repetetive sequence motives.; Title: weak similarity to hypothetical protein AAF50995.2 - Drosophila melanogaster
An12g00320	Catalytic activity: APT1 of S. cerevisiae catalyzes the reaction of AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: APT1 of S. cerevisiae play a role in the purin salvage pathway.; Remark: YML022W is the systematic name for APT1.; Title: strong similarity to adenine phosphoribosyltransferase Apt1 - Saccharomyces cerevisiae; See PMID 7642142
An12g00330	Title: weak similarity to hypothetical protein Rv0923c - Mycobacterium tuberculosis
An12g00340	Function: human alpha 1,2-mannosidase IB processes Man9GlcNAc to Man5GlcNAc.; Title: similarity to alpha 1,2-mannosidase IB - Homo sapiens; See PMID 9592125
An12g00370	Function: the human small nuclear ribonucleoprotein (snRNP) U5 is part of the spliceosome.; Title: strong similarity to U5 snRNP-specific 40 kDa protein - Homo sapiens; See PMID 9774689
An12g00380	Complex: Bet3p is a component of the TRAPP complex which may act upstream of the SNARE complex.; Function: Bet3p of S. cerevisiae is nvolved in targeting and fusion of ER to golgi transport vesicles.; Golgi; Phenotype: bet3-1 at the nonpermissive temperature fails to transport invertase, alpha-factor and carboxypeptidase Y to the Golgi.; Remark: YKR068C is the systematic name for BET3.; Title: strong similarity to Bet3 - Saccharomyces cerevisiae; See PMID 10698928
An12g00390	Title: strong similarity to hypothetical protein SOM1 - Neurospora crassa
An12g00400	Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans
An12g00410	Localization: RBP47 of N. plumbaginifolia is localized in the nucleus.; Remark: RBP47 of N. plumbaginifolia does not stimulate mRNA splicing.; Remark: in vivo UV crosslinking experiments demonstrated that RBP47 of N. plumbaginifolia is associated with the nuclear poly(A)+ RNA.; Title: strong similarity to RNA binding protein 47 RBP47 - Nicotiana plumbaginifolia; nucleus; See PMID 11105760
An12g00440	Title: weak similarity to hypothetical protein SPCC1494.09c - Schizosaccharomyces pombe
An12g00450	Title: similarity to hypothetical protein bK126B4.3 - Homo sapiens
An12g00460	Function: C. albicans DLH1 complements a dmc1/dmc1 null mutant in S. cerevisiae. DLH1 restores both sporulation and meiotic recombination to a Saccharomyces dmc1 delta/dmc1 delta strain.; Remark: C. albicans is a fungus that is thought not to undergo meiosis, yet the presence of an intact homologue of a meiosis-specific gene in C. albicans raises the possibility that this organism has a cryptic meiotic pathway.; Similarity: the predicted A. niger protein shows strong similarity to the functional homologue of the meiosis-specific gene DMC1 (DLH1) of C. albicans.; Title: strong similarity to protein DLH1 - Candida albicans; See PMID 8725225
An12g00470	Title: similarity to hexamer-binding protein HEXBP -Leishmania major; See PMID 8314766
An12g00480	Catalytic activity: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate <=> diphosphate + UDP-N-acetyl-D-glucosamine; Title: strong similarity to UDP-N-acetylglucosamine pyrophosphorylase CaUAP1 - Candida albicans; See PMID 9603950
An12g00490	Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0); Remark: Cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: strong similarity to cyclophilin isoform 10 cyp-10 - Caenorhabditis elegans; See PMID 8694762
An12g00500	Title: weak similarity to hypothetical protein CG7709 - Drosophila melanogaster
An12g00510	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S24.e - Saccharomyces cerevisiae; cytoplasm
An12g00520	Title: similarity to hypothetical membrane protein YJR129c - Saccharomyces cerevisiae
An12g00530	Title: similarity to myosin heavy chain - Gallus gallus
An12g00550	Title: strong similarity to hypothetical protein KIAA1464 - Homo sapiens
An12g00570	Title: similarity to hypothetical protein SPAC23G3.04 - Schizosaccharomyces pombe
An12g00580	Remark: DnaJ protein could behave as a functional heat shock protein in Brucella ovis.; Title: weak similarity to heat shock protein dnaJ -Brucella ovis; See PMID 1459952
An12g00590	Remark: YOR340c is the alternate name for RPA43.; Similarity: the similarity to S. cerevisiae RPA43 is concerning the N-terminal half of the predicted ORF.; Title: similarity to 36 kD subunit of DNA-dependent RNA polymerase I Rpa43 - Saccharomyces cerevisiae; See PMID 7592632
An12g00600	Catalytic activity: NADH + 2 monodehydroascorbate = NAD(+) + 2 ascorbate.; Remark: MDA reductase from Cucumis sativus, an FAD-enzyme, is the first enzyme to be identified whose substrate is an organic radical and catalyzes the reduction of MDA to ascorbate by NAD(P)H.; Title: similarity to monodehydroascorbate reductase MDA - Cucumis sativus; See PMID 7545669
An12g00610	Remark: serine rich proteins.; Remark: shows also similarities to dentin sialophosphoprotein precursor of Homo sapiens.; Title: weak similarity to RNA I and III supressor gene Srp40 - Saccharomyces cerevisiae
An12g00620	Title: strong similarity to hypothetical protein EAA61938.1 - Aspergillus nidulans
An12g00630	Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: Escherichia coli cells with a disrupted diacylglycerol kinase gene are unable to grow on media containing arbutin due to a lethal accumulation of diacylglycerol.; Title: strong similarity to triacylglycerol lipase Tgl2 - Saccharomyces cerevisiae; See PMID 9544243
An12g00640	Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Pathway: oxidative phosphorylation; Photosynthesis; ATP Synthase.; Remark: non-integral membrane component of the membrane integral v0 complex of vacuolar atpase. v-atpase is responible for acidifying a variety of intracellular compartment in eukaryotic cells.; Remark: the protein probably couples ATP hydrolysis and proton translocation.; Similarity: similar to the b-subunit of the F-type ATPase.; Title: strong similarity to vacuolar atp synthase subunit g vma10 - Neurospora crassa; See PMID 9559854; See PMID 10748245
An12g00650	Remark: the nuclear genes PET117 and PET191 are required for the assembly of active cytochrome c oxidase in S. cerevisiae, yet their gene products are not subunits of the final assembled cytochrome c oxidase complex.; Title: similarity to assembly factor of cytochrome c oxidase Pet117 - Saccharomyces cerevisiae; See PMID 8381337; See PMID 8811190
An12g00660	Catalytic activity: L-Tryptophan + O2 = N-Formylkynurenine.; Pathway: Tryptophan metabolism.; Remark: The depletion of an essential amino acid (aa), tryptophan, caused by interferon-gamma (IFN-gamma)-mediated induction of indoleamine 2,3-dioxygenase (IDO) in mouse allografted tumor cells, has been suggested as a reason for the allograft rejection.; Title: similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus; See PMID 1937018
An12g00670	Catalytic activity: Cinnamyl alcohol + NADP+ = Cinnamaldehyde + NADPH.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: acts on coniferyl alcohol, sinapyl alcohol,4-coumaryl alcohol and cinnamyl alcohol.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD14 - Nicotiana tabacum; See PMID 9788995; See PMID 10322194; See PMID 1643282
An12g00680	Remark: it contains a Fungal Zn(2)-Cys(6) binuclear cluster domain.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; nucleus
An12g00690	Title: strong similarity to hypothetical protein CAD21497.1 - Neurospora crassa
An12g00700	Catalytic activity: a Phenyl acetate + H2O = a Phenol + Acetate.; Title: weak similarity to arylesterase EST1 -Acetobacter pasteurianus; See PMID 11330700
An12g00710	Title: strong similarity to hypothetical protein CAD21276.1 - Neurospora crassa
An12g00720	Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Remark: catalyses DNA-template-directed extention of the 3'- end of an RNA strand by one nucleotide at a time. can initiate a chain de novo.; Remark: in eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized.; Remark: the enzyme needs DNA as template.; Title: strong similarity to 138 kD subunit of DNA-dependent RNA polymerase II rpb2p - Schizosaccharomyces pombe; nucleus; See PMID 10605121; See PMID 10916156
An12g00730	Remark: conserved hypothetical protein in different organisms, Schizosaccharomyces pombe, Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans.; Title: strong similarity to hypothetical conserved protein SPAC1952.06c - Schizosaccharomyces pombe
An12g00740	Title: weak similarity to mitochondrial protein TOM6 - Neurospora crassa
An12g00750	Remark: functional studies have shown that the amdR genes are highly conserved and functionally interchangeable between the two species.; Remark: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Remark: the positively acting regulatory gene amdR of Aspergillus nidulans coordinately regulates the expression of five structural genes involved in the catabolism of certain amides (amdS), omega amino acids (gatA and gabA), and lactams (lamA and lamB) in the presence of omega amino acid inducers.; Title: strong similarity to transcription regulator amdR - Aspergillus oryzae; See PMID 2188110; See PMID 1452021
An12g00760	Catalytic activity: Nicotinate D-ribonucleotide + Pyrophosphate = Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate.; Pathway: nicotinate and nicotinamide metabolism.; Remark: htere is a homology to bacterial nicotinate phosphoribosyl transferase.; Title: strong similarity to hypothetical nicotinate phosphoribosyltransferase Npt1 - Saccharomyces cerevisiae; See PMID 7030616; See PMID 8516295; See PMID 10218108
An12g00770	Remark: similarity with the human candidate tumor suppressorp33(ING1).; Remark: the yeast protein is a component of NuA4 histone acetyltransferase complex.; Title: similarity to tumour suppressor p33ING1b ING1 - Homo sapiens; nucleus; See PMID 10805724; See PMID 10866301; See PMID 11076655
An12g00780	Catalytic activity: Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1).; Remark: in yeast it is an essential subunit, since inactivation by deletion or nonsense mutations led to a recessive lethal phenotype.; Title: strong similarity to 31 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; nucleus; See PMID 10384303; See PMID 1400451
An12g00790	Remark: STI1 may play a role in mediating the heat shock response of some HSP70 genes.; Title: strong similarity to stress-induced protein Sti1 - Saccharomyces cerevisiae; See PMID 2674681; See PMID 10567567
An12g00800	Remark: Immunoblotting revealed that vp115 was not actually a component of the glucose transporter-containing vesicles, was most abundant in the plasma membranes and high density microsome fractions of rat adipocytes, and was expressed in all the major rat tissues.; Title: strong similarity to C2-domain family vesicle protein GLUT4 - Rattus norvegicus; See PMID 10350628
An12g00820	Catalytic activity: UTP + alpha-D-Glucose 1-phosphate = Pyrophosphate + UDPglucose.; Pathway: pentose and glucuronate interconversions; Galactose metabolism; Starch and sucrose metabolism; Nucleotide sugars metabolism.; Remark: in yeast a few percent of enzymatic activities leading to the formation of UDP-Glc appears sufficient to provide the UDP-Glc demands required for cell viability.; Remark: the loss of function of UGP1 is lethal mainly because of the inability of yeast cells to properly form the cell wall.; Title: strong similarity to UTP-glucose-1-phosphate uridylyltransferase Ugp1 - Saccharomyces cerevisiae; See PMID 9159472; See PMID 1481573
An12g00830	Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase, respectively.; Remark: there is another homologous regulatory gene from Aspergillus nidulans, nirA, which encodes a protein whose amino-terminal half has approximately 60% amino acid identity with NIT4 but whose carboxy terminus is completely different.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1922075; See PMID 1840634
An12g00840	Remark: activation target is probably a protein or proteins in the basal initiation complex.; Remark: the protein contains the fungal Zn(2)-Cys(6) binuclear cluster domain.; Title: strong similarity to transcription factor ntf1p - Schizosaccharomyces pombe; See PMID 8163491
An12g00850	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the A. niger gene is only one half of the lenght of the P. anserina protein.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402
An12g00860	Remark: the protein contains a domain of glutamine rich residues.; Title: similarity to hypothetical protein AAN36787.1 - Plasmodium falciparum
An12g00870	Remark: Ssu1p mediates efflux of the free form of sulphite.; Title: strong similarity to sulfite resistant protein Ssu1 - Saccharomyces cerevisiae; See PMID 8082198; See PMID 9294463; See PMID 10870099
An12g00880	Catalytic activity: 1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 Vanillin.; Remark: the A. niger protein seems c-terminal 200 aa to long.; Remark: the enzyme catalyses oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. It is responsible for the degradation of a diarylpropane-type structure in lignin.; Title: strong similarity to neoxanthin cleavage enzyme NC1 - Arabidopsis thaliana; See PMID 10611388; See PMID 11006307
An12g00890	Title: weak similarity to ankyrin Ank2 - Mus musculus; See PMID 8486643
An12g00900	Remark: the protein shows only in a small part homology and is 300 aa longer as the homologous protein.; Title: weak similarity to nucleic acid-associated protein 36 BAA90827.1 - Asterina pectinifera; See PMID 10632699
An12g00910	Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Pathway: Glycine, serine and threonine metabolism; Glycerolipid metabolism.; Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Remark: the phosphatidylserine decarboxylases show great lenght variation in different organisms.; Title: similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740; See PMID 10793889
An12g00920	Catalytic activity: 6-Carboxyhexanoyl-CoA + L-Alanine = 8-Amino-7-oxononanoate + CoA + CO2.; Pathway: biotin metabolism.; Remark: strong similarity to many 8-amino-7-oxononanoate synthases from different organisms.; Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; See PMID 9914476; See PMID 10642176
An12g00930	Remark: Tri101 appears to be a defense option which the producers have independently acquired in addition to their original resistance mechanisms.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Gibberella zeae; See PMID 9762900; See PMID 10960733
An12g00940	Remark: SVOP and SV2 are more distantly related to eukaryotic and bacterial phosphate, sugar, and organic acid transporters.; Title: similarity to SV2 related protein SVOP -Rattus norvegicus; See PMID 9801366; See PMID 9868370
An12g00950	Catalytic activity: Random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Gene-ID: rhgA; Remark: the differences in the protein sequence could be determined among sequencing errors or strain variations.; See PMID 8929397; See PMID 9212401
An12g00960	Remark: the dna sequenz is identical to the untranslatetd region of the rhgA gen in the following ORF.; Title: strong similarity to hypothetical protein ydcF - Escherichia coli
An12g00970	Title: similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger
An12g00980	Remark: weak similarity to small domains of different transcription factors.; Title: similarity to hypothetical protein encoded by An18g01730 - Aspergillus niger
An12g00990	Title: questionable ORF
An12g01000	Catalytic activity: acetylcholine + H2O = choline + acetate.; Function: Che1 of B. floridae hydrolyzes acetylthiocholine and butyrylthiocholine.; Remark: Che1 of B. floridae possesses an ethanolamine-glycan-phosphatidylinositol-anchor and most of the protein is anchored in vivo.; Remark: the ORF is longer than Che1 of B. floridae (829 compared to 605 amino acids), the similarity between the two proteins extends over a stretch of about 250 amino acids.; Title: strong similarity to cholinesterase 1 ChE1 -Branchiostoma floridae; See PMID 9062997; See PMID 9874207
An12g01010	Similarity: the ORF is proline-rich and thus has unspecific blast hits to some proteins.; Title: weak similarity to hypothetical protein encoded by An02g01890 - Aspergillus niger
An12g01020	Catalytic activity: acetamidases catalyze the conversion of a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Function: the amdS gene codes for an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providing A. nidulans with a source of carbon and nitrogen.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 7847883
An12g01030	Similarity: blast hits result from repetitive sequences.; Title: similarity to hypothetical protein encoded by An06g00830 - Aspergillus niger
An12g01040	Remark: predicted protein is probably to long at the aminoterminus.; Title: similarity to hypothetical membrane protein YMR221c - Saccharomyces cerevisiae
An12g01060	Function: contains a fungal Zn(2)-Cys(6) binuclear cluster and shows similarity to proteins with this domain,thus it might be involved in regulation of transcription.; Similarity: similarity region to crg1 of C. nicotianae covers aminoacids 300-700.; Title: similarity to cercosporin resistance protein crg1 - Cercospora nicotianae
An12g01070	Remark: the blast results suggest this ORF to be split into two, but due to the blast match against TREMBL:SPBC36B7_5 we do not split this ORF.; Similarity: shows similarity to proteins containing the zinc-binding RING finger motif related FYVE finger motif.; Title: weak similarity to phosphatidylinositol(3)-phosphate binding protein Pib1 -Saccharomyces cerevisiae
An12g01080	Function: contains several domains that are typical for transporter and shows similarity to proteins containing those motifs (compare to PFAM results).; Title: similarity to hypothetical integral membrane protein SPCC1322.03 - Schizosaccharomyces pombe
An12g01100	Similarity: blast hits result from repetive sequences.
An12g01110	Remark: the family of Cys/Met metabolism PLP-dependent enzymes includes enzymes involved in cysteine and methionine metabolism.; Similarity: shows similarity to different members belonging to the family of Cys/Met metabolism PLP-dependent enzymes.; Title: similarity to cystathionine beta-lyase metC -Lactococcus lactis
An12g01120	Function: cnxG of A. nidulans is involved in the conversion of precursor Z to molybdopterin, the intermediate section of the molybdenum cofactor biosynthetic pathway.; Title: strong similarity to molybdopterin synthase small subunit cnxG - Aspergillus nidulans; See PMID 10383438
An12g01140	Function: CYT-4 is thought to regulate mitochondrial RNA splicing by protein phosphorylation.; Remark: no later publications (than 1992) confirming the proposed function of CYT4 as phosphorylase were found. therefore a ribonuclease function of CYT4 might be possible.; Similarity: CYT-4 is similar to the SSD1/SRK1 protein of S. cerevisiae and the DIS3 protein of S. pombe,which have been implicated in protein phosphatase functions that regulate cell cycle and mitotic chromosome segregation.; Similarity: ORF is also similar to many ribonucleases.; Title: strong similarity to protein phosphatase CYT-4 - Neurospora crassa; localisation:mitochondrion; See PMID 2478417; See PMID 1311848
An12g01150	Function: The TRI4 geneproduct catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpene mycotoxins produced by various species of fungi, which can occur on various agricultural products.; Similarity: The TRI4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An12g01170	Function: MatB is part of a three gene cluster (matABC) encoding the malonate-metabolizing system,malonate-->malonyl-CoA-->acetyl-CoA, in R. trifolii.; Similarity: the ORF encoded protein also shows strong similarity to long-chain-fatty-acid-CoA ligases of different species.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii
An12g01180	Title: similarity to protein fragment SEQ ID NO:35753 from patent EP1033405-A2 - Arabidopsis thaliana
An12g01190	Function: SSO1 and SSO2 of yeast encode syntaxin homologs (post-Golgi t-SNAREs), they act in late stages of secretion.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Title: strong similarity to syntaxin-related protein (T-SNARE) Sso2 - Saccharomyces cerevisiae; See PMID 8223426
An12g01210	Function: PTR2 of S. cerevisiae facilitates the uptake of small peptides.; Localization: PTR2 of S. cerevisiae is a integral membrane protein.; Similarity: PTR2 of S. cerevisiae belongs to the PTR2 transporter family.; Title: strong similarity to peptide transport protein Ptr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8264579
An12g01220	Title: questionable ORF
An12g01250	Remark: the transport of pyruvate and lactate across cellular membranes is an essential process in mammalian cells and is mediated by the H+/monocarboxylate transporters (MCTs).; Title: strong similarity to monocarboxylate transporter 4 MCT4 - Mus musculus; See PMID 10926847
An12g01260	Catalytic activity: Nitrile + H2O = Carboxylate + NH3.; Function: The nitrilase genes of A. thaliana (NIT1-4) encode very similar proteins that hydrolyze indole-3-acetonitrile to the phytohormone indole-3-acetic acid.; Remark: Gene structure was manually adjusted fit the Arabidopsis nit1 gene.; Title: strong similarity to nitrilase NIT1 -Arabidopsis thaliana; See PMID 1555601; See PMID 8022831
An12g01270	Similarity: This ORF is also similar to many hypothetical proteins with similar lenth.; Similarity: hypothetical protein has similarity to C-terminal part of many alanyl-tRNA synthetases.; Title: similarity to hypothetical alanine--tRNA ligase alaS - Streptomyces coelicolor
An12g01280	Catalytic activity: ATP + L-Citrulline + L-Aspartate = AMP + Pyrophosphate + N(omega)-(L-Arginino)succinate.; Title: strong similarity to argininosuccinate synthase argG - Streptomyces clavuligerus; See PMID 8566818
An12g01290	remark: N-terminally truncated ORF due to end of contig.
An12g01300	Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450
An12g01310	Similarity: ORF is also similar to hypothetical peptidoglycan binding domain protein, a and beta-mannosidase precursor and a glucan 1,3-beta-glucosidase.; Title: strong similarity to hypothetical protein PA2063 - Pseudomonas aeruginosa
An12g01320	Function: Linoleate diol synthase is a homotetrameric ferric hemeprotein, which catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate.; Remark: The linoleate diol synthase is a cyclooxygenase-related dioxygenase.; Similarity: Belongs to family of fatty acid heme dioxygenases.; Similarity: The linoleate diol synthase is similar to prostaglandin H synthases.; Title: strong similarity to linoleate diol synthase - Gaeumannomyces graminis; See PMID 10497176; See PMID 10667399
An12g01330	Remark: The eIF4E gene of S. pombe encodes the cap-binding component eIF4E.; Title: strong similarity to translation initiation factor eIF-4E - Schizosaccharomyces pombe
An12g01340	Function: Adult mice homozygous for the Mpv17 deletion developed nephrotic syndrome and chronic renal failure.; Similarity: ORF is also similar to peroxisomal membrane proteins.; Title: strong similarity to hypothetical protein mpv17 - Mus musculus
An12g01350	Function: S4 of yeast is important in the assembly and function of the 40S ribosomal subunit.; Function: mutations in S4 of yeast affect the control of translational fidelity.; Remark: S4 of yeast is also called omnipotent suppressor protein SUP44.; Similarity: S4 of yeast belongs to the S5p family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S4 - Saccharomyces cerevisiae; cytoplasm; See PMID 2247072
An12g01360	Cofactor: Heme.; Similarity: Similarity to many different cytochrome P450 proteins.; Title: strong similarity to hypothetical cytochrome P450 protein 2E4.050 - Neurospora crassa
An12g01370	Similarity: Most weak blast hits are caused by repetetive sequence elements.; Title: similarity to hypothetical protein encoded by An04g06340 - Aspergillus niger
An12g01380	Cofactor: NADPH.; Function: krd of Z. rouxii catalyzes the asymmetric reduction of selected ketone substrates.; Function: krd of Z. rouxii reduces alpha-ketolactones, alpha-ketolactams, and diketones.; Similarity: Similarity to many different reductases.; Similarity: krd of Z. rouxii belongs to the carbonyl reductase enzyme class.; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208
An12g01410	Title: questionable ORF
An12g01420	Title: weak similarity to hypothetical helicase protein Cag-omega from cagI pathogenicity island -Helicobacter pylori; See PMID 8962108
An12g01440	Title: weak similarity to hypothetical cation efflux system protein czcB3 - Aquifex aeolicus
An12g01460	Function: NOP-1 may function as a rhodopsin in N. crassa photobiology.; Function: Opsins are a class of retinal-binding,seven transmembrane helix proteins that function as light-responsive ion pumps or sensory receptors.; Remark: nop-1 expression of N. crassa is regulated by light and conidiation.; Title: strong similarity to opsin nop-1 - Neurospora crassa; See PMID 10393943; See PMID 10571987
An12g01470	Title: strong similarity to hypothetical protein encoded by An12g01780 - Aspergillus niger
An12g01480	Catalytic activity: ATP + L-Isoleucine + tRNA(Ile) = AMP + Pyrophosphate + L-Isoleucyl-tRNA(Ile).; Title: strong similarity to mitochondrial isoleucine--tRNA ligase Ism1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6304034; See PMID 7607232
An12g01490	Complex: KIF17, a molecular motor interacts with the PDZ domain of mouse Lin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis) and the NR2B subunit of the NMDA receptor.; Complex: rat lin-10 interacts with neurabin-II/spinophilin, which has recently been isolated as a protein interacting with protein phosphatase I and F-actin.; Function: lin-10 is required for the targeting of transmembrane receptors to the basolateral surface via specific cytosceleton dependent transport.; Localization: rat lin-10 is distributed in both the cytosol and membrane fractions.; Title: similarity to transport regulator lin-10 -Rattus norvegicus; intracellular transport vesicles; See PMID 9480860; See PMID 9514910; See PMID 10610414; See PMID 10846156
An12g01500	Function: A. nidulans bimC mutations interfere with separation of the spindle pole bodies, cause abnormal spindle morphology and prevent nuclear division.; Title: strong similarity to kinesin-like mitotic spindle organising factor bimC - Aspergillus nidulans; See PMID 2138511
An12g01510	Remark: the systematic name for S. cerevisiae APC11 is YDL008w.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal half of the S. cerevisiae RING-finger protein APC11, which is 400 aa shorter.; Similarity: the predicted A. niger protein contains a RING-finger domain.; Title: similarity to RING-finger ubiquitin ligases (E3) Apc11 - Saccharomyces cerevisiae; See PMID 10888670
An12g01520	Function: human TST catalyzes the transfer of sulfur in thiosulfate and other compounds to cyanide ion to form thiocyanate ion; Localization: TST localises in the mitochondrial matrix in animal tissues.; Title: strong similarity to thiosulfate sulfurtransferase TST - Homo sapiens; localisation:mitochondrion; See PMID 1953758
An12g01530	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_2527.; Remark: the systematic name for S. cerevisiae RGD1 is YBR260c.; Title: weak similarity to Rho3 and Rho4 GTPase activating protein Rgd1 - Saccharomyces cerevisiae; See PMID 10526184
An12g01540	Similarity: the ORF shows strong similarity to EST EMBLEST:BE760874 an_0852 - Aspergillus niger.; Similarity: the predicted A. niger protein contains a DNA-binding motif and shows similarity to the putative DNA-binding domain of a fusion protein resulting from chromosomal rearrangements in human acute megakaryoblastic leukemias.; Title: similarity to hypothetical protein dJ1042K10.5 - Homo sapiens; See PMID 11431691
An12g01550	Complex: human Trax (Translin-associated factor X) has been shown to interact with TB-RBP/Translin by its coimmunoprecipitation and in yeast two-hybrid assays,forming heterodimers.; Function: Translin/TB-RBP is a single-stranded DNA-and RNA-binding protein which can bind the 3' UTR regions (Y and H elements) of stored mRNAs and can suppress in vitro translation of the mRNAs that contain these sequences.; Function: human Trax-Translin/TB-RBP interactions modulate the DNA- and RNA-binding activity of Translin/TB-RBP, while Trax has no DNA/RNA-binding activity by itself.; Localization: cell fractionation and confocal microscope studies reveal that human Trax is predominantly cytoplasmic.; Title: similarity to modifier of Translin DNA/RNA-binding Trax - Homo sapiens; cytoplasm; See PMID 9013868; See PMID 11027506
An12g01560	Function: N. crassa QA-Y was identified as quinic acid permease by sequence similarity and mutant phenotype.; Similarity: N. crassa QA-Y belongs to the major facilitator family.; Title: strong similarity to quinic acid permease QA-Y - Neurospora crassa; See PMID 2976880; See PMID 1533844
An12g01570	Catalytic activity: gluconolactonases convert D-glucono-1,5-lactone + H(2)O to D-gluconate; Function: gluconolactonase is involved in the biosynthesis of different monosaccharides, like ribose and xylulose, from glucose.; Title: strong similarity to gluconolactonase -Zymomonas mobilis; See PMID 1482681
An12g01580	Catalytic activity: A. thaliana PGDH catalyses the oxidation of 3-phosphoglycerate to phosphohydroxypyruvate.; Function: A. thaliana PGDH is involved in serine biosynthesis.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of A. thaliana PGDH,which is 300 aa longer.; Title: similarity to 3-phosphoglycerate dehydrogenase PGDH - Arabidopsis thaliana; See PMID 9867856
An12g01590	Function: S. cerevisiae PPR1 regulates expression of pyrimidine biosynthetis genes.; Similarity: the predicted A. niger protein shows similarity to several fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing transcription factors,however it contains no such domain by itself.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 6278253; See PMID 7958913
An12g01600	Function: S. cerevisiae PPR1 regulates expression of pyrimidine biosynthetis genes.; Similarity: the predicted A. niger protein shows similarity to several fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing transcription factors,however it contains no such domain by itself.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 6278253; See PMID 7958913
An12g01610	Catalytic activity: macrophomate synthase converts 5-acetyl-4-methoxy-6-methyl-2-pyrone (1) to 4-acetyl-3-methoxy-5-methylbenzoic acid (macrophomic acid,2). -; Function: macrophomate synthase is a Mg(II)-dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical transformation from 2-pyrone and oxalacetate to benzoate involving decarboxylation, C-C bond formation, and dehydration.; Title: similarity to macrophomate synthase -Macrophoma commelinae; See PMID 10731719; See PMID 10984474
An12g01620	Function: in B. cepacia 4-hydroxyphthalate,4-chlorophthalate, 4-methylphthalate, and cinchomeronate compete for the phthalate permease.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; plasma membrane; See PMID 10498738
An12g01630	Title: strong similarity to hypothetical protein EAA59080.1 - Aspergillus nidulans
An12g01640	Remark: blastp with the predicted A. niger protein only retrieves putative random hits to serine and proline rich proteins.; Title: weak similarity to mucin - Sus scrofa
An12g01650	Similarity: the predicted A. niger protein contains an ankyrin motif.; Title: similarity to polypeptide SEQ ID NO 29028 from patent WO200171042-A2 - Drosophila melanogaster
An12g01660	Similarity: the predicted A. niger protein contains an ankyrin motif.; Title: weak similarity to vertebrate left-right axis determinant inversin inv - Mus musculus; See PMID 9771707
An12g01670	Catalytic activity: monophenol monooxygenases convert L-tyrosine + L-DOPA + O(2) to L-DOPA + DOPAquinone + H(2)O.; Function: tyrosinase is a copper containing monooxygenase catalyzing the formation of melanin pigments and other polyphenolic compounds from various phenols.; Title: strong similarity to tyrosinase melO -Aspergillus oryzae; See PMID 6308414; See PMID 7893753
An12g01680	Title: weak similarity to oxidoreductase OXRD-8 from patent DE29916782-U1 - Homo sapiens
An12g01690	Title: similarity to hypothetical protein F2J6.1 -Arabidopsis thaliana
An12g01700	Function: S. cerevisiae CHA4 is involved in transcriptional activation of catabolic L-serine (L-threonine) deaminase via the serine/threonine response element.; Similarity: similarity is between the N-terminal 2/3s of the predicted A. niger protein and S. cerevisiae CHA4, which is 100 aa longer.; Similarity: the predicted A. niger protein contains a N-terminal fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; nucleus; See PMID 8889513
An12g01710	Function: might be a short chain dehydrogenase of unknown specificity.; Remark: the patent comprises novel human nucleic acid sequences from tumor breast tissue which have cytostatic activity.; Similarity: shows strong similarity to probable short chain dehydrogenases of different organisms.; Title: strong similarity to human breast tumour-associated protein 77 from patent DE19813839-A1 -Homo sapiens
An12g01720	Function: patent WO9957280-A2 covers neisserial polypeptides predicted to be useful antigens for vaccines and diagnostics SEQ ID NO:124.; Similarity: covers only a part of the patent sequence.; Title: weak similarity to ORF 297 protein sequence from patent WO9957280-A2 - Neisseria meningitidis
An12g01730	Function: the family of short chain dehydrogenases contains a wide variety of dehydrogenases involved in for example glycolysis/gluconeogenesis, fatty acid metabolism,bile acid biosynthesis, etc.; Function: the gene encoding this sequence of patent JP09075093-A are specifically expressed during the growth of cotton fibre.; Remark: blast hit against protein of patent JP09075093-A.; Remark: putative sequencing error around pos. 73231.; Similarity: predicted protein shows strong similarity to probable oxidoreductase of different organisms.; Title: strong similarity to cotton fibrous tissue specific protein from patent JP09075093-A - Gossypium barbadense [putative frameshift]; putative frameshift
An12g01750	Title: strong similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An12g01760	Similarity: shows only short similarity to protein of B. burgdorferi.; Title: weak similarity to antigen P93 from patent WO9512676-A1 - Borrelia burgdorferi
An12g01770	Similarity: shows only short partial similarity to human protein.; Title: weak similarity to gastric mucin MUC5AC -Homo sapiens
An12g01780	Remark: protein of the patent is useful useful for diagnosis or vaccine production.; Title: weak similarity to viral protein encoded by ORF1 of ET-NANB (HEV) Burma strain from patent US5824649-A - Hepatitis E virus
An12g01790	Title: similarity to hypothetical protein encoded by An06g00800 - Aspergillus niger
An12g01800	Function: it is a alpha-1,3-glucanase; alpha-1,3-glucanohydrolase.; Function: mutanase is composed of two distinct domains: a NH(2)-terminal catalytic domain and a putative COOH-terminal polysaccharide-binding domain separated by a O-glycosylated Pro-Ser-Thr-rich linker peptide.; Remark: same enzyme of T. harzianum is patented WO9818437-A1 and used as component for dental care products.; Similarity: shows similarity to the aminoterminal part of mutanase of several fungi.; Title: similarity to mutanase mutA - Trichoderma harzianum; See PMID 10636904
An12g01810	Similarity: shows only partial similarity at the aminoterminus.; Title: weak similarity to glutamine--tRNA ligase QARS - Homo sapiens
An12g01820	Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Similarity: shows strong similarity to several ubiquitin thiolesterase but is around 100 AA longer at the aminoterminus.; Title: similarity to ubiquitin thiolesterase L3 -Homo sapiens; See PMID 2530630
An12g01830	Title: weak similarity to hypothetical ATP-binding protein bax - Escherichia coli
An12g01840	Title: similarity to hypothetical protein related to meiosis-specific protein NDT80 - Neurospora crassa
An12g01850	Function: glycosidase enzymes from organisms of the genera Staphlothermus, Pyrococcus and Thermococcus - for deriving sugar from oligosaccharides, useful in the e. g. food processing, textile or baking industries.; Localization: might be an extracellular/secreted protein.; Title: strong similarity to glycosidase from patent WO9824799-A1 - Thermotoga maritima; See PMID 11210501; See PMID 11210502
An12g01870	Similarity: might be longer at the aminoterminus because blast search showed similarity at pos. 44141-43934.; Similarity: shows only partial similarity to several transcription factors.; Title: similarity to positive regulator of the lactose-galactose regulon LAC9 - Kluyveromyces lactis; nucleus
An12g01880	Function: PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER and glycosylphosphatidylinositol (GPI) acts as a membrane anchor of many cell surface proteins.; Title: strong similarity to mannosyltransferase PIG-M - Homo sapiens; endoplasmatic reticulum; See PMID 11226175
An12g01890	Function: the central isoprenoid pathway concerned with the synthesis of prenyl lipids is present in C. utilis and active in the biosynthesis of ergosterol.; Function: the influential steps in the pathway that were manipulated were 3-hydroxy methylglutaryl coenzyme A (HMG-CoA) reductase, encoded by the HMG gene, and squalene synthase, encoded by the ERG9 gene.; Function: through metabolic engineering of the isoprenoid pathway, a sevenfold increase in the yield of lycopene has been achieved.; Title: strong similarity to squalene synthase ERG9 -Candida utilis; See PMID 9647847
An12g01900	Function: DnaJ homologues act in conjunction with molecular chaperones of the Hsp70 protein family in a variety of cellular processes.; Localization: the S. cerevisiae DJP1 gene encodes a cytosolic protein homologous to Escherichia coli DnaJ.; Title: strong similarity to dnaJ protein homolog YIR004w - Saccharomyces cerevisiae; cytoplasm; See PMID 9679141
An12g01910	Function: phytase as component of a feed composition for monogastric animals (e. g., pigs, poultry) enhances the nutritional value of plant material without the need for adding additional phosphate to the feed.; Function: the enzyme showed high activity with 4-nitrophenyl phosphate at a pH range of 3 to 5 and with phytic acid at a pH range of 2. 5 to 7. 5.; Function: the gene (phyA3) encoding a heat-stable enzyme has been cloned from A. fumigatus and overexpressed in A. niger.; Remark: shows also high similarity to patent EP969089-A1 that describes a consensus protein sequence (included is A. niger).; Title: strong similarity to phytase phyA3 -Aspergillus fumigatus; extracellular/secretion proteins
An12g01920	Title: strong similarity to hypothetical protein Pa5G0034 - Podospora anserina
An12g01930	Function: expression of the mouse cDNA in cultured mouse cells resulted in a nearly 10-fold increase in the incidence of point mutations.; Function: the E. coli dinB gene is an SOS gene known to be required for lambda phage untargeted mutagenesis.; Function: the product DinB is structurally related to the E. coli UmuC protein and the S. cerevisiae Rev1 and Rad30 proteins, all of which are shown to be involved in bypass synthesis at a DNA lesion.; Similarity: is around 200 AA shorter than the murine protein but longer than other predicted protein with similiar function.; Title: similarity to homologue of the E.coli mutagenesis protein DinB - Mus musculus; See PMID 10620008
An12g01940	Function: protein of E. nidulans seems to be involved in double-strand break repair.; Remark: paper might be published soon.; Similarity: shows weak similarity to patent WO9955716-A1 (nibrin of H. sapiens).; Title: strong similarity to campothecin resistance conferring protein rcaA - Aspergillus nidulans
An12g01950	Remark: the ORF shows an significant match against the EST an_2509 from Aspergillus niger.; Title: strong similarity to hypothetical protein CAD60583.1 - Podospora anserina
An12g01960	Complex: component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563
An12g01970	Title: similarity to hypothetical protein encoded by An01g00420 - Aspergillus niger
An12g01980	Catalytic activity: (3r)-3-hydroxyacyl-[acyl-carrier protein] + nadp(+) = 3-oxoacyl-[acyl-carrier protein] + nadph.; Catalytic activity: acetyl-coa + n malonyl-coa + 2n nadph = long-chain fatty acid + (n+1) coa + n co(2) + 2n nadp(+).; Catalytic activity: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + co(2) + [acyl-carrier protein].; Complex: fatty acid synthetase are [alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha & beta).; Complex: this subunit coordinates the binding of the six beta subunits to the enzyme complex.; Function: fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-coa,malonyl-coa and nadph.; Function: the alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.; Similarity: to the fatty acid synthetase, subunit alpha from other fungi.; Title: strong similarity to fatty acid synthase alpha subunit Fas2 - Saccharomyces cerevisiae; cytoplasm
An12g01990	Catalytic activity: this subunit of fatty acid synthetase, with five different catalytic activities, bears four distinct domains.; Complex: the yeast fatty acid synthase is a complex (alpha 6 beta 6) of two multifunctional proteins alpha and beta.; Title: strong similarity to fatty-acyl-CoA synthase beta chain fas1p - Schizosaccharomyces pombe; cytoplasm
An12g02000	Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida [putative frameshift]; putative frameshift; See PMID 2363715
An12g02010	Similarity: the similarity of the ORF encoded protein to the protein sequence from ORF 982 Neisseria meningitidis is only based on repetitive structures.; Title: weak similarity to hypothetical protein At2g22660 - Arabidopsis thaliana
An12g02020	Function: the trichothecene 3-O-acetyltransferase TRI101 from F. sporotrichioides converts isotrichodermol to isotrichodermin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Pathway: F. sporotrichioides TRI101 is required for the biosynthesis of T-2 toxin.; Remark: Fusarium and related fungi produce trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 8246841; See PMID 10583973
An12g02030	Title: weak similarity to hypothetical ATP-binding ABC transporter protein - Deinococcus radiodurans
An12g02040	Remark: the regulatory Aspergillus niger acuA mutation, which leads to the lost of acetyl-CoA synthetase (ACS) activity can be complemented with the A. niger facB gene.; Similarity: the FacB protein from A. niger is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 10483720
An12g02050	Function: the A. nidulans wA PKS gene has been identified to encode a heptaketide naphthopyrone synthase.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Title: strong similarity to polyketide synthase wA -Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 11251292
An12g02060	Title: strong similarity to hypothetical protein encoded by An03g02680 - Aspergillus niger
An12g02070	Function: the the ribonuclease T1 precursor RntA from Aspergillus oryzae catalyzes degradation of RNA in a two-stage endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.; Title: similarity to ribonuclease T1 precursor rntA - Aspergillus oryzae; See PMID 8534978; See PMID 10029539
An12g02080	Function: A. nidulans stcS catalyzes the conversion of versicolorin A to sterigmatocystin.; Pathway: A. nidulans stcS is involved in the sterigmatocystin biosynthesis.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Remark: alternate name for A. nidulans stcS is verB.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 7486998; See PMID 8643646
An12g02090	Function: nit-4 of N. crassa is a transcription factor activating gene expression of nitrate assimilatory genes nit-3 and nit-6, which encode nitrate reductase and nitrite reductase, respectively.; Remark: activation of nit-3 and nit-6 requires the synergisitc interaction of the global-acting nit-2 with the pathway-specific nit-4 transcription factors.; Similarity: the nit-4 protein from N. crassa is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1829047
An12g02100	Function: Mmf1p influences the maintenance of mitochondrial DNA (mtDNA) and the cell division time. Mammalian members of this protein family may be implicated in regulation of protein translation.; Localization: electron microscopy immunogold labeling shows that S. cerevisiae Mmf1 is present in the mitochondrial matrix, and analysis of the different submitochondrial fractions demonstrated that Mmf1p is a soluble protein of the matrix.; Remark: alternate names for S. cerevisiae Mmf1: YIL051c or Mmd1.; Similarity: the ORF encoded protein and the S. cerevisiae Mmf1 protein belong to the conserved UK114 protein family.; Title: similarity to mitochondrial matrix factor 1 Mmf1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11003673
An12g02110	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein CAD70448.1 - Neurospora crassa
An12g02120	Similarity: the similarities of the ORF encoded protein to matching proteins with an E-val less than 3e-11 are mainly based on repetitive structures.; Title: similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus
An12g02130	Title: weak similarity to hypothetical protein KIAA1235 - Homo sapiens
An12g02150	Title: questionable ORF
An12g02170	Remark: truncated ORF due to end of contig.
An12g02180	Title: similarity to hypothetical protein encoded by An12g09970 - Aspergillus niger
An12g02190	Title: strong similarity to hypothetical protein encoded by An12g09960 - Aspergillus niger
An12g02200	Function: the stress induction of Hsp30 acts to reduce stress stimulation of the H+-ATPase.; Induction: expression of S. cerevisiae Hsp30 is induced by heat shock, ethanol treatment, and entry into stationary phase.; Remark: alternate names for S. cerevisiae Hsp30: YRO1 or YCR021C.; Similarity: S. cerevisiae Hsp30 belongs to the archaeal opsin family and to the Hsp30 subfamily.; Title: strong similarity to heat shock protein Hsp30 - Saccharomyces cerevisiae; plasma membrane; See PMID 9250391; See PMID 9414109; See PMID 7812443
An12g02210	Similarity: the FacB protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An12g02220	Function: the biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. CHB2 from Trichoderma reesei is an exocellobiohydrolases.; Title: strong similarity to cellulose 1,4-beta-cellobiosidase II CBH2 - Trichoderma reesei; See PMID 8875646; See PMID 2377893; See PMID 3596237
An12g02240	Catalytic activity: ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly).; Function: the glycyl-tRNA synthetase gene GRS1 encodes both cytoplasmic and mitochondrial activities in S. cerevisiae.; Remark: alternate name for S. cerevisiae Grs1: YBR121C.; Title: strong similarity to glycine--tRNA ligase Grs1 - Saccharomyces cerevisiae; See PMID 10874035
An12g02300	Title: similarity to hypothetical protein encoded by An12g02310 - Aspergillus niger
An12g02310	Title: similarity to hypothetical protein encoded by An12g02300 - Aspergillus niger
An12g02320	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: FabG from Salmonella typhimurium catalyzes the first reduction step in the fatty acid biosynthesis pathway.; Similarity: the ORF encoded protein and FabG from Salmonella typhimurium belong to the short-chain dehydrogenases/reductases (SDR) family.; Title: similarity to 3-oxoacyl-(acyl carrier protein) reductase fabG - Salmonella typhimurium; See PMID 9642179
An12g02330	Function: the AiiA enzyme from Bacillus sp. 240B1 degrades N-acylhomoserine lactone.; Remark: N-acylhomoserine lactones, known as autoinducers (AIs), are widely conserved signal molecules present in quorum-sensing systems of many gram-negative bacteria.; Similarity: AiiA from Bacillus sp. 240B1 contains a 'HXHXDH' zinc-binding motif that is conserved in several groups of metallohydrolases.; Title: similarity to acylhomoserine lactone signal inactivating enzyme aiiA - Bacillus sp.; See PMID 10716724
An12g02340	Function: PnbA from B. subtilis catalyzes the hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An12g02350	Function: S. cerevisiae Lys14 activates the transcription of lysine biosynthesis genes. This activation is dependent on the inducer alpha-aminoadipate semialdehyde and repressed by lysine.; Remark: alternate name for S. cerevisiae Lys14: YDR034C.; Similarity: the ORF encoded protein also shows significant domain homology to many fungal binuclear Zn(2)-Cys(6) cluster transcription factors.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus; See PMID 7935367
An12g02360	Catalytic activity: Hippurate + H(2)O <=> benzoate + glycine.; Title: similarity to hippurate hydrolase HipO -Campylobacter jejuni; See PMID 7730270
An12g02370	Function: the MCT3 protein from rat is a proton-linked monocarboxylate transporter, that catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555
An12g02380	Function: the c-ski gene product (c-Ski) was found to bind to N-CoR (nuclear hormone receptor co-repressor),an element implicated in transcriptional repression mediated by multiple transcriptional repressors including the nuclear hormone receptors and Mad. c-Ski is required for transcriptional repression mediated by Mad involved in negative regulation of cellular proliferation.; Title: similarity to transforming protein ski - Homo sapiens; nucleus; See PMID 9371722; See PMID 9988677
An12g02390	Title: similarity to hypothetical protein CAC28841.2 - Neurospora crassa
An12g02400	Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae
An12g02410	Function: germins are a family of homopentameric cereal glycoproteins expressed during germination which may play a role in altering the properties of cell walls during germinative growth.; Function: spherulin is a major encystment specific protein.; Similarity: belongs to the germin-like family.; Title: strong similarity to precursor of spherulin 1a - Physarum polycephalum; cell wall
An12g02420	Function: phenylcoumaran benzylic ether reductases,2'-hydroxyisoflavone reductases and pinoresinol-lariciresinol reductases are involved in the biosynthesis of important and related phenylpropanoid-derived plant defense compounds; Similarity: shows also strong similarity to several plant 2'-hydroxyisoflavone reductases and pinoresinol-lariciresinol reductases.; Title: strong similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa; See PMID 10066819
An12g02430	Catalytic activity: 4-coumarate-CoA ligase catalyzes the conversion of ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.; Title: strong similarity to 4-coumarate-CoA ligase 4CL1 - Populus trichocarpa
An12g02440	Title: similarity to hypothetical ATP-binding protein SCCB12.04 - Streptomyces coelicolor
An12g02450	Similarity: shows strong similarity to several glucosyltransferases with different specificities.; Title: strong similarity to alpha-glucan synthase mok1p - Schizosaccharomyces pombe; See PMID 10087262
An12g02460	Catalytic activity: alpha-amylase catalyses the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Function: alpha-amylase acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration.; Title: strong similarity to alpha-amylase -Aspergillus niger
An12g02470	Similarity: shows similarity to several different oxidoreductases.; Title: similarity to NADPH-protochlorophyllide-oxidoreductase - Pinus mugo
An12g02490	Function: putative transcription factor, due to motifs.; Similarity: shows similarity to several transcriptional regulators, but the homology regions covers always only the zinc finger motif region.; Title: weak similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus
An12g02500	Remark: lovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An12g02510	Similarity: shows some similarity to major capsid protein orf25 of Herpesvirus saimiri.
An12g02520	Remark: patent WO9503416-A.; Remark: the enzyme is used to catalyse the biosynthesis of clavulanic acid from a precursor clavulanic acid aldehyde. The obtained clavulanic acid is in turn a key ingredient in the antibiotic Augmentin.; Title: strong similarity to clavulanic acid dehydrogenase from patent WO9503416-A - Streptomyces clavuligerus
An12g02540	Remark: the gene (cel1) expressing the 1. 3-kb mRNA,is differentially regulated by the carbon source of the culture medium.; Title: similarity to cellulose-growth-specific protein cel1 - Agaricus bisporus; See PMID 1398098
An12g02550	Remark: strong similarity only to the C-terminus of xynD, as the predicted ORF is 298 amino acids shorter at the N-terminus.; Remark: xynD specifically release only esters of 5-5'diFA from either xylanase-treated or insoluble fractions of cell walls, even though other esterified dimers were solubilized by preincubation with xylanase.; Title: similarity to esterase D xynD - Pseudomonas fluorescens; See PMID 8373350; See PMID 8979352
An12g02560	Remark: only in the C-terminal domain is weak similarity.; Title: weak similarity to protein-tyrosine phosphatase SH-PTP2 - Rattus norvegicus; See PMID 8048963
An12g02590	Title: similarity to hypothetical protein SPAC10F6.16 - Schizosaccharomyces pombe
An12g02600	Remark: Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces and that multiple signaling pathways mediate differentiation.; Remark: the Pth11p protein is approximately in the C-terminal region 200 amino acids longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An12g02620	Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa
An12g02630	Remark: patent WO9911793-A1.; Remark: the patent is useful in the diagnosis,prevention, and treatment of infectious, vesicle trafficking, immunological, and neoplastic disorders.; Title: strong similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens
An12g02640	Remark: patent WO9833896-A2; Remark: the patent protein is useful for producing clavulanic acid without production of 5S clavam or clavam-2-carboxylates.; Title: strong similarity to clavin biosynthesis gene orfup1 from patent WO9833896-A2 - Streptomyces clavuligerus; See PMID 10223939
An12g02650	Similarity: the predicted ORF shows similarity to various methyltransferases.; Title: similarity to 24-sterol C-methyltransferase ESMT1 - Zea mays
An12g02660	Similarity: the blastp matches are mainly based on repetetive structures.
An12g02670	Remark: fumonisins are toxins associated with several mycotoxicoses and are produced by the maize pathogen Gibberella fujikuroi mating population A (MP-A). Biochemical analyses indicate that fumonisins are a product of either polyketide or fatty acid biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella fujikuroi; See PMID 10413619
An12g02680	Title: weak similarity to hypothetical protein encoded by An02g12900 - Aspergillus niger
An12g02690	Title: weak similarity to cytochrome b5 CB5 - Oryza sativa; See PMID 8049375
An12g02700	Catalytic activity: D-Gluconate + NAD+ or NADP+ = 5-Dehydro-D-gluconate + NADH or NADPH.; Remark: GNO is involved in the nonphosphorylative,ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate.; Remark: there is a great variety in the substrate specificity and cellular localizations in the short-chain alcohol dehydrogenase family.; Similarity: to members of the short-chain alcohol dehydrogenase family.; Title: strong similarity to gluconate 5-dehydrogenase GNO - Gluconobacter oxydans; See PMID 7981120; See PMID 7751271
An12g02710	Remark: CFP encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting cercosporin, thus maintaining low cellular concentrations of the toxin.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Remark: reduced expression of the membrane pump protein results in a reduction in cercosporin production,making the fungus less pathogenic to plants and also less able to protect itselt against cercosporin.; Remark: similarity to Cercospora kikuchii membrane pump protein patent WO9735001-A1.; Title: similarity to cercosporin transporter CFP -Cercospora kikuchii; See PMID 10517030
An12g02720	Remark: the sequence shows also similarity to the N-terminus of dihydrofolate reductases.; Title: similarity to hypothetical protein C25G4.2 -Caenorhabditis elegans
An12g02730	Remark: PKS1 is a multifunctional polyketide synthase (PKS)-encoding gene (PKS1) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase, and acyl carrier protein.; Remark: the polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; See PMID 10913297
An12g02740	Remark: patent WO9743303-A1 and WO9737026-A1.; Title: weak similarity to ATP-dependent proteinase Clp from patent WO9743303-A1 - Streptococcus pneumoniae
An12g02750	Remark: due to its unusual lenght the protein could be a new polyketidesynthase.; Remark: similarity to polyketidsynthases.; Remark: similarity to the N-terminal region of acid-CoA ligases.; Title: similarity to FK520 biosynthetic gene cluster polyketide synthase fkbB - Streptomyces hygroscopicus; See PMID 9780228; See PMID 10863099
An12g02760	Title: similarity to hypothetical protein BAB49075.1 - Mesorhizobium loti
An12g02770	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: only the N-terminal part shows similarity to het1-e1.; Remark: the C-terminal part shows similarity to ankyrin like proteins and death inducer proteins.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An12g02780	Remark: the sequence shows only with the N-terminal part similarity to AbsR1, but is 300 aa longer.; Title: strong similarity to hypothetical protein AAO55050.1 - Pseudomonas syringae
An12g02790	Catalytic activity: 3-(2-Hydroxyphenyl)propanoate + NAD+ = 2-Coumarate + NADH.; Pathway: phenylalanine metabolism.; Remark: PCBER is preferentially produced in the secondary xylem of stems and roots and is associated with the active growth period.; Remark: the enzyme is putative involved in lignan synthesis.; Title: strong similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa; See PMID 9664291; See PMID 11030549
An12g02800	Remark: TPO1 is a polyamine transport protein on the vacuolar membrane.; Similarity: to multidrug resistance proteins.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9678606; See PMID 9920864
An12g02810	Catalytic activity: S-Adenosyl-L-methionine + Sterigmatocystin = S-Adenosyl-L-homocysteine + 7-O-Methylsterigmatocystin.; Remark: RT-PCR data demonstrated that both the avfA and avfA1 as well as omtB genes in A. parasiticus were expressed only in the aflatoxin-conducive medium.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: the biosynthesis of aflatoxins (B(1), G(1),B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361
An12g02820	Remark: azole resistance in Candida albicans can be mediated by several resistance mechanisms.; Remark: the fluconazole resistance protein seems N-and C-terminal longer.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; See PMID 11181345
An12g02830	Title: weak similarity to hypothetical methyltransferase adpE - Anabaena sp.; See PMID 10931313
An12g02840	Remark: LPS1 activates the three amino acids of the peptide portion of ergot peptide alkaloids during D-lysergyl peptide assembly.; Title: strong similarity to d-lysergyl-peptide-synthase PS1 - Claviceps purpurea; See PMID 10071219; See PMID 1281482
An12g02850	Catalytic activity: NADPH + Oxidized thioredoxin = NADP+ + Reduced thioredoxin.; Pathway: pyrimidine metabolism; Remark: patent EP0565172-A/1.; Title: strong similarity to sulphydryl oxidase Sox from patent EP565172-A1 - Aspergillus niger
An12g02860	Similarity: to efflux pumps and resistance proteins.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994
An12g02880	Title: weak similarity to zinc binuclear cluster protein sequence #124 from patent WO200224865-A2 -Unclassified organism
An12g02890	Catalytic activity: L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate + L-Glutamate.; Pathway: valine, leucine and isoleucine degradation; valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: TOXF has a biosynthetic role in HC-toxin synthesis, perhaps to aminate a precursor of Aeo (2-amino-9, 10-epoxi-8-oxodecanoic acid).; Title: strong similarity to branched-chain amino acid aminotransferase TOXF - Cochliobolus carbonum; See PMID 10627051
An12g02900	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An12g02920	Similarity: the predicted ORF is 205 amino acids longer at the N-terminus than chiA of B. circulans; the similarity concerns the inner region of both proteins.; Title: weak similarity to chitinase A1 chiA -Bacillus circulans; See PMID 2203782
An12g02930	Title: weak similarity to ankyrin-related protein unc-44 - Caenorhabditis elegans; See PMID 7744957
An12g02950	Remark: the similarity is only in a small part of the ankyrins.; Title: weak similarity to 190 kDa ankyrin isoform AnkG190 - Rattus norvegicus; See PMID 9727010
An12g02970	Catalytic activity: a Phosphoprotein + H2O = a Protein + Orthophosphate.; Remark: protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated.; Remark: the use of specific PP2A inhibitors and molecular genetics in yeast, Drosophila and mice has revealed roles for PP2A in cell cycle regulation, cell morphology and development.; Title: strong similarity to phosphatase 2A ACP2 -Homo sapiens; See PMID 11171037; See PMID 2837763
An12g02980	Catalytic activity: a phosphoprotein + H2O = a protein + orthophosphate.; Remark: in A. nidulans, the temperature-sensitive,recessive cell cycle mutation bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans; See PMID 11104818; See PMID 2544297
An12g02990	Title: similarity to hypothetical protein encoded by An14g01970 - Aspergillus niger
An12g03010	Catalytic activity: Isochorismate + H2O = 2,3-Dihydro-2,3-dihydroxybenzoate + Pyruvate.; Pathway: ubiquinone biosynthesis; Remark: the cytosolic proteins EntE, EntF, and EntB/G, which are Escherichia coli enzymes necessary for the final stage of enterobactin synthesis, are released by osmotic shock.; Remark: the siderophore molecule enterobactin, a cyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)serine,is synthesized and secreted by Escherichia coli in response to iron starvation.; Title: similarity to isochorismatase entB -Escherichia coli; See PMID 9485415; See PMID 10692387; See PMID 2139796
An12g03020	Remark: shows also similarity to unknown geneproduct in the Aspergillus terreus lovastatin biosynthesis gene cluster.; Title: strong similarity to dityrosine transporter Dtr1 - Saccharomyces cerevisiae; See PMID 9678606; See PMID 10436161
An12g03040	Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester.; Remark: acts on RNA-DNA hybrids. Similar enzymes are obtained from E. coli, chicken embryo, human KB cells, rat liver, Ustilago maydis, human leucaemic cells, S. cerevisiae (H2), and Tetrahymena.; Remark: also strong similarity to Human type 2 RNase H protein patent WO9928447-A1.; Title: similarity to ribonuclease H1 Rnh1 - Mus musculus; See PMID 9181574; See PMID 9799596
An12g03050	Title: strong similarity to hypothetical protein encoded by An11g05880 - Aspergillus niger
An12g03070	Title: strong similarity to hypothetical protein SPAC4H3.03c - Schizosaccharomyces pombe
An12g03100	Remark: the ORF encoded protein ist N-terminally truncated due to contig boundary.; Title: strong similarity to hypothetical protein CAD71224.1 - Neurospora crassa [truncated ORF]
An12g03110	Function: the membrane pump protein of C. kikuchii confers resistance to the polyketide phytotoxin cercosporin.; Title: strong similarity to membrane pump protein from patent WO9735001-A1 - Cercospora kikuchii [truncated ORF]; plasma membrane; See PMID 10517030
An12g03120	Function: lipP of Pseudomonas sp. shows 1,3-positional specificity towards triolein.; Function: lipP of Pseudomonas sp. shows high activity towards short-chain to medium-chain fatty acids.; Similarity: lipP of Pseudomonas sp. belongs to the 'gdxg' family of lipolytic enzymes.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382
An12g03130	Remark: the similarity of the ORF encoded protein is only based on repetitive amino acids.
An12g03140	Remark: the homology is mainly based on repetitiv amino acids.; Title: weak similarity to hypothetical megakaryocyte stimulating factor - Mus musculus
An12g03150	Phenotype: Delta atrD mutants in A. nidulans display a hypersensitive phenotype to compounds such as cycloheximide, the cyclosporin derivative PSC 833,nigericin and valinomycin, indicating that AtrDp is involved in protection against cytotoxic compounds.; Similarity: atrD of A. nidulans shows similarity to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082
An12g03160	Remark: a splice site was detected upstream of the START codon.
An12g03170	Function: facB of A. nidulans encodes a Zn(II)2Cys6 transcriptional activator.; Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; nucleus; See PMID 9197408; See PMID 9367656
An12g03180	Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715
An12g03190	Title: strong similarity to hypothetical protein YAL049c - Saccharomyces cerevisiae
An12g03200	Function: human actVA-ORF4-like protein is useful in the treatment of infectious, vesicle trafficking,immunological and neoplastic disorders.; Remark: the ORF encoded protein also shows weak similarity to several transkription factors.; Title: similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens
An12g03210	Function: the nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins. athway: nor-1 of A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: nar-1 is an alternative name for nor-1.; Similarity: nor-1 of A. parasiticus belongs to the short-chain dehydrogenases/reductases (sdr) family.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 7993094
An12g03220	Title: similarity to hypothetical protein encoded by slr0318 - Synechocystis sp
An12g03230	Catalytic activity: l-serine + 1-(indol-3-yl)glycerol 3-phosphate = l-tryptophan + glyceraldehyde 3-phosphate + H(2)O.; Pathway: last (fifth) step in biosynthesis of tryptophan.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to tryptophan synthase-encoding trpB - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 10905354
An12g03240	Catalytic activity: acetyl-CoA + arylamine = CoA + N-acetylarylamine.; Remark: pineal gland isozyme NAT-10 and arylamine acetylase are alternative names for arylamine N-acetyltransferase.; Similarity: belongs to the arylamine N-acetyltransferase family.; Title: similarity to arylamine N-acetyltransferase -Gallus gallus; See PMID 2583181
An12g03250	Title: similarity to immunogenic protein #5097 from patent WO200181581-A2 - Propionibacterium acnes
An12g03260	Catalytic activity: (3S)-3-Hydroxyacyl-CoA + NAD+ = 3-Oxoacyl-CoA + NADH.; Title: strong similarity to 3-hydroxyacyl-CoA dehydrogenase hmgA - Sulfolobus solfataricus; See PMID 9171410
An12g03270	Title: similarity to hypothetical BH0305 - Bacillus halodurans
An12g03290	Catalytic activity: catalyzes the conversion of RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Gene-ID: maoN
An12g03300	Title: strong similarity to aspartic protease pr1 -Phaffia rhodozyma; extracellular/secretion proteins
An12g03330	Remark: blast matches are random.; Title: weak similarity to protein-tyrosine-phosphatase ptp-bk - Mus musculus
An12g03350	Title: weak similarity to hypothetical protein encoded by An08g04870 - Aspergillus niger
An12g03370	Title: similarity to protein fragment SEQ ID NO:37063 from patent EP1033405-A2 - Arabidopsis thaliana
An12g03380	Title: weak similarity to transcription factor BKLF - Mus musculus
An12g03400	Title: weak similarity to transcription factor MHY1 - Yarrowia lipolytica
An12g03420	Similarity: shows similarity to N-terminal part of gap of M. hominis.; Title: weak similarity to glyceraldehyde 3-phosphate dehydrogenase gap - Mycoplasma hominis
An12g03440	Catalytic activity: glucose oxidase catalyzes the conversion of Beta-D-glucose + O(2) <=> D-glucono-1,5-lactone + H(2)O(2).; Title: similarity to glucose oxidase goxC -Aspergillus niger
An12g03460	Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 9140969; See PMID 10613888; See PMID 8437566
An12g03480	Title: weak similarity to hypothetical protein encoded by An12g03490 - Aspergillus niger
An12g03490	Title: weak similarity to hypothetical protein encoded by An12g03480 - Aspergillus niger
An12g03500	Title: weak similarity to hypothetical protein CAD71089.1 - Neurospora crassa
An12g03510	Title: strong similarity to hypothetical protein encoded by An15g07630 - Aspergillus niger
An12g03530	Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Remark: a putative sequencing error results in an frameshift.; Title: similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides [putative frameshift]; putative frameshift
An12g03550	Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3301804
An12g03570	Catalytic activity: catalyzes the conversion of orotidine-5'-phosphate = UMP + CO2.; Gene-ID: pyrA;pyrG; Mapping: pyrA/pyrG from A. niger is mapped to chromosome III; see list from DSM, EMBL X96734.; Pathway: sixth and last step in the biosynthesis of pyrimidines.; Remark: pyrA ang pyrG from A. niger are probable identical.; Similarity: belongs to the omp decarboxylase family.; See PMID 8650301; See PMID 3357784
An12g03580	Catalytic activity: glutathione S-transferases catalyze the conversion of RX + glutathione <=> HX + R-S-glutathione.; Title: strong similarity to microsomal glutathione S-transferase 3 MGST3 - Homo sapiens
An12g03600	Catalytic activity: diacylglycerol acyltransferases catalyze the conversion of acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.; EC:2.3.1.20; Function: diacylglycerol acyltransferase DAGAT of A. thaliana catalyzes the acylation of diacylglycerol by oleoylcoA to give triacylglycerol.; Remark: might alternatively be a sterol O-acyltransferase.; Title: strong similarity to diacylglycerol acyltransferase DAGAT - Arabidopsis thaliana; See PMID 10601854
An12g03620	Function: Pfs2p of S. cerevisiae is required for mRNA 3'-end processing, it bridges two mRNA 3'-end processing factors.; Remark: the systematic genename of PFS2 of S. cerevisiae is YNL317w.; Remark: truncated ORF due to end of contig.; Title: similarity to polyadenylation factor I subunit 2 Pfs2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10619842
An12g03640	Remark: truncated ORF due to end of contig.
An12g03630	Title: similarity to hypothetical membrane protein YPR153w - Saccharomyces cerevisiae
An12g03650	Remark: PEX17 is required for the import of a subset of matrix proteins into peroxisomes in Yarrowia lipolytica.; Title: similarity to peroxisomal membrane protein PEX17 - Yarrowia lipolytica; peroxisome; See PMID 9111320
An12g03660	Catalytic activity: S-adenosyl-L-methionine + protein S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.; EC:2.1.1.100; Remark: STE14 mediates C-terminal methylation of the isoprenylated C-terminal cysteine in a-factor mating pheromone and RAS-proteins in S. cerevisiae.; Remark: STE14 null mutant exhibits a profound block in a-factor export in S. cerevisiae.; Title: strong similarity to farnesyl cysteine carboxyl-methyltransferase Ste14 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8212897
An12g03670	EC:2.3.1.-; Function: maltose O-acetyltransferase mac of E. coli acetylates glucose, maltose, mannose, galactose and fructose in Escherichia coli.; Function: putative O-acetyltransferase.; Title: strong similarity to maltose O-acetyltransferase maa - Escherichia coli; See PMID 1856235
An12g03680	Protein sequence is in conflict with the conceptual translation; putative sequencing error
An12g03700	Function: Ubiquitin-specific proteases (UBPs) are a family of unique hydrolases that specifically remove polypeptides covalently linked via peptide or isopeptide bonds to the C-terminal glycine of ubiquitin.; Title: strong similarity to ubiquitin specific protease UBP12 - Arabidopsis thaliana; See PMID 11115897
An12g03710	Title: strong similarity to alpha subunit of transcription initiation factor TFIIE Tfa1 - Saccharomyces cerevisiae; nucleus; See PMID 7961670
An12g03720	Catalytic activity: tRNA-pseudouridine synthase catalyzes the conversion of tRNA uridine to tRNA pseudouridine.; Remark: Pus1p in S. cerevisiae is an intranuclear protein which exhibits a nucleotide-specific and intron-dependent tRNA pseudouridine synthase activity.; Remark: possible sequencing error at position 28835; 2 bp too much.; Title: strong similarity to tRNA-pseudouridine synthase I Pus1 - Saccharomyces cerevisiae [putative frameshift]; nucleus; putative frameshift; See PMID 8641292
An12g03730	Function: Sen1 of S. cerevisiae is involved in tRNA processing.; Similarity: the ORF is shorter than Sen1 of S. cerevisiae and the homology between the two proteins is restricted to a stretch of about 300 amino acids.; Title: similarity to ATP dependent RNA helicase Sen1 - Saccharomyces cerevisiae; See PMID 8544822; See PMID 9365256; See PMID 9819377; See PMID 1569945
An12g03740	Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: weak similarity to hypothetical protein encoded by An12g03800 - Aspergillus niger
An12g03750	Remark: the ORF has an unusual exon/intron structure for A. niger.
An12g03760	Title: similarity to hypothetical protein encoded by An12g03780 - Aspergillus niger
An12g03770	Title: similarity to hypothetical protein encoded by An12g03780 - Aspergillus niger
An12g03780	Similarity: shows also weak similarity to vimentin and myosin of different organisms.; Title: weak similarity to hypothetical methyl-accepting chemotaxis related protein PAB1308 -Pyrococcus abyssi
An12g03790	Title: weak similarity to elongation factor Ts tsf -Guillardia theta
An12g03800	Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: weak similarity to hypothetical protein encoded by An12g03740 - Aspergillus niger
An12g03810	Remark: the ORF is short in sequence.
An12g03830	Function: alpha INT1 of C. albicans mediates enhanced aggregation/adhesion and plays a role in morphogenesis.; Similarity: the ORF is shorter than alpha INT1 of C. albicans (1349 compared to 1664 amino acids) and the homology between the two proteins is restricted to a central stretch of about 400 amino acids.; Title: similarity to integrin-like protein alpha chain alpha INT1 - Candida albicans; See PMID 8552638
An12g03850	Function: CHR1 of C. albicans complements a rok1 mutant of S. cerevisiae which is required for cell cycle progression and also for rRNA processing.; Remark: a putative sequencing error results in an frameshift.; Title: similarity to DEAD box RNA helicase CHR1 -Candida albicans [putative frameshift]; nucleus; putative frameshift; See PMID 10705369
An12g03860	EC:3.1.1.-; Function: putative carboxylic esterase.; Remark: possible sequencing error at position 1047,2 bp too much.; Similarity: shows similarity to several kinds of different esterases, e. g. acetylcholinesterases,triacylglycerol lipases.; Title: strong similarity to precursor of cephalosporin esterase - Rhodosporidium toruloides [putative frameshift]; putative frameshift; See PMID 9406399
An12g03880	Title: similarity to hypothetical protein SPCC4B3.12 - Schizosaccharomyces pombe
An12g03890	Title: strong similarity to mitochondrial ribosomal protein of the large subunit L14 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626
An12g03900	Function: enzyme of S. cerevisiae is required for normal cell growth over a wide temperature range, but is not essential for synthesis of mRNA.; Title: strong similarity to 14.2 kD subunit of DNA-directed RNA polymerase II Rpb9 - Saccharomyces cerevisiae; nucleus; See PMID 1918023
An12g03910	Function: pin1 may modulate cell cycle control through interaction with Cdc25 and its activator, Plx1.; Function: the cis/trans peptidyl-prolyl isomerase,Pin1, is a regulator of mitosis that is well conserved from yeast to man.; Title: strong similarity to peptidyl-prolyl cis/trans isomerase pinA - Aspergillus nidulans; nucleus
An12g03920	Title: strong similarity to hypothetical protein EAA57929.1 - Aspergillus nidulans
An12g03930	Function: CBC mediates the effect of the cap structure in U snRNA export, and provide direct evidence for the involvement of a cellular RNA-binding factor in the transport of RNA to the cytoplasm.; Function: cap structures are added cotranscriptionally to all RNA polymerase II transcripts and affect several processes including RNA stability,pre-messenger RNA splicing, RNA export from the nucleus and translation initiation.; Localization: might be a nuclear protein.; Title: strong similarity to CAP binding protein CBP20-X - Xenopus laevis; See PMID 7651522
An12g03940	Remark: in Cercospora pyridoxine auxotrophy due to gene disruption.; Title: strong similarity to hypothetical pyridoxine synthesis protein PDX2 - Cercospora nicotianae
An12g03950	Remark: npgA of E. nidulans maps next to aatA and might also be involved in biosynthesis of penicillin or other antibiotics.; Title: strong similarity to hypothetical protein npgA - Aspergillus nidulans
An12g03960	Function: the penicillin biosynthesis is catalysed by three enzymes encoded by acvA (pcbAB), ipnA (pcbC) and ataA (penDE).; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to acyltransferase ataA -Aspergillus nidulans; See PMID 9729600; See PMID 10422583
An12g03970	Function: The recessive, temperature-sensitive bimA1 mutation of Aspergillus nidulans blocks nuclei in metaphase at restrictive temperature.; Function: the sequence of the bimA gene indicates that it is a member of a family of mostly nuclear proteins that contain a degenerate 34 amino acid repeat, the TPR (tetratricopeptide repeat) gene family. -; Title: strong similarity to nuclear protein bimA -Aspergillus nidulans; nucleus
An12g03980	Title: strong similarity to hypothetical protein AAN52526.1 - Pichia angusta
An12g03990	Title: strong similarity to hypothetical protein EAA57923.1 - Aspergillus nidulans
An12g04000	Function: it could also be an activator of 3'-5' ribonuclease or might be directly implicated in association with the RNA14 protein in the nuclear polyadenylation of the mRNAs.; Function: protein of S. cerevisiae may be a nuclease which would normally be inactive owing to inhibition by wild-type RNA14 protein and could be activated either as a normal component of mRNA decay or during some specific cellular stress.; Localization: integral membrane protein.; Similarity: shows similarity at carboxyterminus to several known and putative mrna stability proteins.; Title: similarity to mrna stability protein Ssm4 -Saccharomyces cerevisiae
An12g04010	Similarity: shows partial similarity mainly to Arabidopsis sequences.; Title: similarity to hypothetical protein encoded by An09g00360 - Aspergillus niger
An12g04020	Catalytic activity: it converts ATP + Acetyl-CoA + HCO(3)(-) = ADP + + malonyl-CoA.; Catalytic activity: it converts ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + Orthophosphate.; Cofactor: biotin.; Function: the S. pombe protein carries three functions i. e. biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.; Localization: cytoplasmic.; Pathway: first step in long-chain fatty acid synthesis.; Similarity: strong similarity to acetyl-CoA carboxylase accA A. nidulans.; Title: strong similarity to acetyl-CoA carboxylase SPAC56E4.04c - Schizosaccharomyces pombe; cytoplasm; See PMID 9871120
An12g04030	Function: NUDE, is a homologue of the nuclear distribution protein RO11 of Neurospora crassa.; Function: movement and distribution of nuclei in fungi have been shown to be dependent on cytoplasmic microtubules and the microtubule-associated motor cytoplasmic dynein.; Similarity: similar to Neurospora crassa RO11.; Title: strong similarity to nuclear distribution protein nudE - Aspergillus nidulans; cytoplasm; See PMID 10931877
An12g04050	Remark: the ORF encoded protein also shows similarity to CSHase of Arthrobacter sp from patent R22271. .; Title: similarity to hypothetical protein b1011 -Escherichia coli
An12g04060	Remark: the ORF also shows similarity to the EST d1g09a1. r1 of Aspergillus nidulans.; Title: similarity to hypothetical protein SPAC29A4.06c - Schizosaccharomyces pombe
An12g04070	Phenotype: in S. cerevisiae zrt3 mutants inefficiently mobilize stored zinc to offset deficiency.; Remark: YKL175w is an alternative name for ZRT3.; Similarity: Zrt3p is a member of the ZIP family of metal transporters.; Title: similarity to zinc-transporter Zrt3 -Saccharomyces cerevisiae; vacuole; See PMID 10856230
An12g04090	Title: similarity to hypothetical protein encoded by An04g09490 - Aspergillus niger
An12g04110	Phenotype: mitochondrial DNA recombination was reduced in an yeast mutant lacking the NUC1 endo/exonuclease.; Similarity: the ORF encoded protein shows strong similarity to several described mitochondrial nucleases.; Title: strong similarity to precursor of mitochondrial nuclease Nuc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8087883; See PMID 2836791
An12g04120	Title: similarity to hypothetical protein T25B24.3 -Arabidopsis thaliana
An12g04130	Remark: blastp matches are unspecific.
An12g04140	Title: similarity to hypothetical Sec76 domain protein - Schizosaccharomyces pombe
An12g04150	Remark: blastp matches are due to repetitive amino acids.
An12g04170	Function: ECM14 of S. cerevisisae is involved in cell wall biogenesis and architecture.; Similarity: the ORF encoded protein shows similarity to different types of carboxypeptidases.; Title: similarity to Ecm14 - Saccharomyces cerevisiae; See PMID 9335584
An12g04180	Function: DIP5 of S. cerevisiae mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate.; Phenotype: the dip5 mutation caused a several hundred-fold reduction of uptake of L-glutamate and L-aspartate.; Remark: YPL265W is an alternative name for DIP5.; Similarity: DIP5 of S. cerevisiae belongs to the amino acid permease family.; Title: strong similarity to dicarboxylic amino acid permease Dip5 - Saccharomyces cerevisiae; plasma membrane; See PMID 9508791
An12g04190	Remark: YBT1 and YLL048C are alternative names for BAT1.; Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Similarity: the ORF encoded protein shows similarity to various ABC transporters with different function.; Title: strong similarity to bile acid transporter Bat1 - Saccharomyces cerevisiae [truncated ORF]; vacuole; See PMID 9182565
An12g04210	Catalytic activity: PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism.; Remark: Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate.; Remark: PhacA is a novel cytochrome P450 monooxygenase.; Title: strong similarity to phenylacetate 2-hydroxylase phacA - Aspergillus nidulans; See PMID 10329644
An12g04220	Catalytic activity: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH.; Function: HdhA catalyses the oxidation of the 7-alpha-hydroxyl group of bile acids and alcohols both in their free and conjugated forms.; Title: similarity to 7-alpha-hydroxysteroid dehydrogenase hdhA - Escherichia coli; See PMID 2007545
An12g04250	Function: PDAT9 from the fungus Nectria haematococca encodes pisatin demethylase, an enzyme that detoxifies the phytoalexin pisatin, an antimicrobial compound produced by pea in response to infection by this plant pathogen.; Remark: a putative sequencing error results in an frameshift.; Similarity: PDAT9 is a cytochrome P450 whose deduced amino acid sequence is distinct from all other reported cytochrome P-450s, and therefore has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca [putative frameshift]; putative frameshift; See PMID 2034215; See PMID 8208242
An12g04260	Catalytic activity: UDP-glucose = UDP-galactose.; Pathway: Galactose metabolism.; Title: similarity to UDP-glucose 4-epimerase GALE -Streptomyces lividans; See PMID 3335481
An12g04280	Function: The serine esterase est from Acinetobacter calcoaceticus confers the ability to grow on simple triglycerides such as triacetin (TAC).; Similarity: Belongs to the GDXG family of lipolytic enzymes.; Title: similarity to esterase est - Acinetobacter calcoaceticus; See PMID 2545531
An12g04310	Catalytic activity: Cinnamyl alcohol+NADP(+)<=>cinnamaldehyde+NADPH.; Function: CAD1 from Eucalyptus gunnii catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Pathway: lignin biosynthesis.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii [putative frameshift]; putative frameshift; See PMID 9526508
An12g04320	Title: weak similarity to hypothetical protein clone Bal50 - Unclassified organism
An12g04330	Catalytic activity: NADH + acceptor <=> NAD(+) + reduced acceptor.; Cofactor: FAD, FeS.; Title: strong similarity to thermostable NADH oxidase - Thermoanaerobium brockii; See PMID 1599437; See PMID 8357835
An12g04340	Function: the human zeta-crystallin/quinone reductase CRYZ is specific for NADPH. It catalyses the one electron reduction of certain quinones. Orthoquinones are the best substrates.; Similarity: the ORF encoded protein shows also strong similarities to many Arabidopsis thaliana patent oxidoreductases which are functionally not decribed.; Title: strong similarity to zeta-crystallin/quinone reductase CRYZ - Homo sapiens; See PMID 8466529
An12g04350	Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: LipP from Pseudomonas sp. B11-1 is a lipase that showes a 1,3-positional specificity toward triolein. p-Nitrophenyl esters of fatty acids with short to medium chains (C4 and C6) served as good substrates.; Title: similarity to lipase LipP - Pseudomonas sp.; See PMID 9464382
An12g04360	Remark: the prostate specific androgen regulated protein ARSDR1 from patent WO200065067-A2 is identical to the androgen-regulated short-chain dehydrogenase/reductase 1 (TREMBL:AF167438_1).; Title: similarity to prostate specific androgen regulated protein ARSDR1 from patent WO200065067-A2 - Homo sapiens; See PMID 11245473
An12g04370	Remark: A. parasiticus moxY is part of the aflatoxin biosynthetic pathway gene cluster and is expressed concurrently with genes involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719
An12g04380	Title: strong similarity to immunogenic protein #19801 from patent WO200181581-A2 - Propionibacterium acnes
An12g04390	Function: the 12-hydroxydehydrogenase LTB4DH from Sus scrofa catalyzes the conversion of leukotriene b4 into its biologically less active metabolite, 12-oxo-leukotriene b4. This is an initial and key step of metabolic inactivation of leukotriene b4 in various tissues other than leukocytes.; Similarity: the ORF encoded protein shows also strong similarities to many Arabidopsis thaliana patent oxidoreductases which are functionally not decribed.; Title: strong similarity to NADP dependent leukotriene b4 12-hydroxydehydrogenase LTB4DH - Sus scrofa; See PMID 8576264
An12g04410	Remark: the ORF is short in length (58 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An12g04450	Remark: the ORF contains many Prolins.; Title: similarity to EST SEQ ID NO:4177 from patent WO200056762-A2 - Aspergillus niger
An12g04460	Title: similarity to EST SEQ ID NO:4349 from patent WO200056762-A2 - Aspergillus niger
An12g04470	Remark: hoxN gene has several features typical of a hydrophobic integral membrane protein. Alkaline phosphatase fusion proteins produced by insertion of the transposon TnphoA into hoxN gave significant levels of alkaline phosphatase activity indicating that protein HoxN contains periplasmic domains. Taken together, our results suggest that gene hoxN encodes the high-affinity nickel transporter of A. eutrophus.; Title: strong similarity to high affinity nickel transporter - Ralstonia eutropha; See PMID 7896709; See PMID 7934894; See PMID 1847142
An12g04480	Catalytic activity: chitin + H2O = chitosan + acetate.; Pathway: aminosugars metabolism.; Remark: strong similarity to C. lindemuthianum chitin deacetylase patent DE19810349-A1.; Remark: the protein of the patent is also used to produce chitosan oligosaccharides from chitin oligosaccharides and for removing N-acetyl from other amino sugars, making it suitable for synthesis of new sugar chains.; Title: strong similarity to chitin deacetylase from patent DE19810349-A1 - Colletotrichum lindemuthianum
An12g04490	Remark: mRNA expression of pol lambda is highest in mouse testis and fetal liver. The biological function may differ from DNA translesion synthesis.; Title: strong similarity to DNA polymerase lambda POLL - Mus musculus; See PMID 10982892
An12g04500	Catalytic activity: ATP + H2O = ADP + orthophosphate.; Pathway: oxidative phosphorylation.; Remark: hydrolysis of ATP is coupled with the transport of Ca2+ ions. The enzyme from the plasma membrane of eucaryotes differs from that found in sarcoplasmic reticulum in that it is activated by calmodulin, is sensitive to low concentrations of vanadate, and is of higher molecular mass (150 kDa).; Similarity: belongs to the cation transport ATPases.; Title: strong similarity to transport ATPase Drs2 -Saccharomyces cerevisiae; See PMID 8247005; See PMID 9852106; See PMID 10601336
An12g04510	Catalytic activity: benzoate + NADPH + O2 = 4-hydroxybenzoate + NADP+ + H2O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: phenylalanine metabolism.; Remark: analysis revealed that CYP53 is a member of a P450 gene family designated P450LIII.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 2250647
An12g04520	Function: probable transporter. confers resistance to cycloheximide.; Remark: the CYHR gene from Candida maltosa confers resistance to cycloheximide.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family). belongs to the car1/cyhr subfamily.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An12g04530	Catalytic activity: versicolorin B synthase of A. parasiticus catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of versicolorin B.; Pathway: versicolorin B synthase catalyzes an essential transformation in the aflatoxin biosynthetic pathway of A. parasiticus.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: putative sequencing error at position 27713,1 base too much and at position 26638; putative sequencing error leads to a STOP Codon.; Remark: the biosynthesis of aflatoxin B1 proceeds through three configurationally labile intermediates to racemic versiconal hemiacetal. Subsequent enzymatic cyclization establishes the stereochemistry of this,critical ring fusion in (-)-versicolorin B and is catalyzed by versicolorin B synthase (VBS).; Remark: vbs of A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes; however, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: belongs to the choline dehydrogenase and related flavoproteins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus [putative frameshift]; putative frameshift; See PMID 8662689; See PMID 8784203
An12g04540	Title: weak similarity to hypothetical protein CAD60719.1 - Podospora anserina
An12g04560	Complex: the human 75-kD autoantigen (PM-Sc1) is part of the nuclear/nucleolar particle termed PM-Scl (polymyositis/scleroderma). the PM-Scl complex consists of 11 to 16 proteins.; Remark: the PM/Scl complex is the human counterpart of the yeast (S. cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases.; Remark: the exosome plays a major role in diverse RNA processing and degradation pathways.; Remark: yeast Rrp45p is homologous to PM-Scl75.; Similarity: the predicted A. niger protein shows strong similarity to the human 75-kD autoantigen (PM-Sc1) and related conserved hypothetical proteins from procaryotic and eucaryotic species, which belong to the RNase PH family.; Title: strong similarity to 75-kD autoantigen PM-Sc1 - Homo sapiens; See PMID 10465791; See PMID 11178117; See PMID 2007859
An12g04570	Title: strong similarity to hypothetical protein BAA90629.1 - Oryza sativa
An12g04590	Catalytic activity: 5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH; Function: dihydrofolate reductase catalyzes the reduction of dihydrofolic acid to tetrahydrofolic acid with NADPH an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis), and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.; Similarity: similarity to dihydrofolate reductase of several species is restricted to aminoterminus.; Title: similarity to dihydrofolate reductase DHFR -Pneumocystis carinii; See PMID 2682653
An12g04600	Function: CIC-3 in rat may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.; Remark: a splice site was detected upstream of the START codon.; Remark: alternative splicing at the aminoterminus possible because of long and short forms of chloride channels.; Similarity: strong similarity to chloride channels at the aminoterminus but no similarity at the carboxyterminus.; Title: similarity to protein kinase C-regulated chloride channel ClC3 - Rattus rattus; See PMID 8155321
An12g04610	Function: might be involved in degradation of cellulose or similiar substances.; Similarity: restricted to aminoterminus, partial similarity might point to a pseudogene.; Title: similarity to endoglucanase IV egl4 -Trichoderma reesei; See PMID 9370370
An12g04620	Function: might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: patent W14439 against protein.; Title: similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An12g04630	Function: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA).; Remark: alternative splicing possible.; Similarity: shows strong similarity to proteins of patents W00291 (full length) and W00290 (mature).; Title: strong similarity to full length Penicillin V amidohydrolase from patent US5516679-A - Fusarium oxysporum
An12g04640	Function: isoamyl acetate hydrolytic enzyme of S. cerevisiae is involved in C-compound and carbohydrate utilization and fermentation.; Function: might be a lipase/acylhydrolase with GDSL-like motif according to pfam-domain.; Remark: patent not found in DSM-patentdatabase.; Similarity: shows also similarity to isoamyl acetate hydrolytic enzyme of S. cerevisiae.; Title: similarity to sequence 28 from patent WO0032789 - Mangifera indica
An12g04650	Title: weak similarity to hypothetical secreted antigen SagA - Enterococcus faecium
An12g04655	Title: strong similarity to hypothetical protein AAF47250.1 - Drosophila melanogaster
An12g04660	Function: gene disruption demonstrated that the thi6 null strain is auxotrophic for thiamin, indicating that the THI6 protein is essential for thiamin synthesis in yeast.; Function: thiamin-phosphate pyrophosphorylase (TMP-PPase; EC 2. 5. 1. 3) involved in de novo synthesis of thiamin in S. cerevisiae is a bifunctional enzyme with 4-methyl-5-beta-hydroxyethylthiazole kinase (Th-kinase; EC 2. 7. 1. 50) activity.; Title: strong similarity to thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase Thi6 -Saccharomyces cerevisiae; See PMID 7982968
An12g04670	Function: eukaryotic translation initiation factor 5 (eIF-5) catalyzes hydrolysis of GTP bound to a 40 S ribosomal initiation complex with the subsequent joining of a 60 S ribosomal subunit to form an 80 S initiation complex.; Remark: a splice site was detected upstream of the START codon.; Remark: translation initiation factor eIF-5 exists as long and short form (alternative splicing).; Title: strong similarity to translation initiation factor Eif-5 - Saccharomyces cerevisiae; cytoplasm
An12g04680	Title: similarity to hypothetical protein SPCC622.13c - Schizosaccharomyces pombe
An12g04690	Function: DNA ligases catalyze the formation of phosphodiester bonds at single-strand breaks in double-strand DNA.; Similarity: DNA ligases of several species seem to be highly variable at the aminoterminus.; Title: strong similarity to ATP-dependent DNA ligase LigI - Xenopus laevis; nucleus; See PMID 8682316
An12g04700	Function: Tri r 4 is associated with IgE antibody binding and delayed type hypersensitivity in Homo sapiens.; Function: dipeptidyl peptidase IV (DPP IV) is responsible for the removal of N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini, provided that the penultimate residue is proline.; Similarity: similarity to several peptidase families.; Title: strong similarity to allergen Tri r 4 -Trichophyton rubrum
An12g04710	Function: a novel gene family in which null mutations cause pleiotropic effects on metal-ion resistance or sensitivity and distribution of membrane proteins in different targets was discovered.; Function: deletion of the VTC1 gene (DeltaVTC1) results in a reduced amount of V-ATPase in the vacuolar membrane.; Function: the family was defined as VTC (Vacuolar Transporter Chaperon) and it contains four genes in the S. cerevisiae genome.; Function: these mutant cells fail to accumulate quinacrine into their vacuoles, but they are able to grow at pH 7. 5. The VTC1 null mutant also results in a reduced amount of the plasma membrane H(+)-ATPase (Pma1p) in membrane preparations and possibly mis-targeting.; Similarity: similarity to VTC1 is only partial because VTC1 is much smaller but the predicted protein might be a member of the same family.; Similarity: strong similarity to several fungal hypothetical proteins.; Title: similarity to negative regulator of Cdc Fourty two Vtc1 - Saccharomyces cerevisiae; See PMID 10480897
An12g04720	Complex: the predominant form is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7, sometimes called the RLF-M component of replication licensing factor.; Function: as replication proceeds, MCM proteins are phosphorylated and dissociate from the chromatin.; Function: part of the replication licensing system that permits DNA replication to occur once and only once within a single cell division cycle.; Function: the complex of six MCM proteins is one of several proteins that must be bound at the origins of replication for the initiation of DNA replication.; Title: strong similarity to replication licensing factor mcm4p - Schizosaccharomyces pombe; nucleus
An12g04730	Similarity: shows only wear similarity at the aminoterminus.; Title: similarity to hypothetical membrane protein YMR266w - Saccharomyces cerevisiae
An12g04740	Function: N-delta-arginine methylation may be important during logarithmic growth and may be dispensable or even deleterious during post-exponential growth.; Title: similarity to N-delta-arginine methyltransferase Rmt2 - Saccharomyces cerevisiae; See PMID 9873020
An12g04750	Complex: Phb2p of S. cerevisiae forms a large multimeric complex with Phb1p.; Function: Phb1/Phb2 complex of S. cerevisiae is involved in stabilization of mitochondrial proteins.; Function: prohibitins are ubiquitous, abundant and evolutionarily strongly conserved proteins that play a role in important cellular processes.; Function: prohibitins in S. cerevisiae regulate membrane protein degradation and replicative lifespan.; Remark: the systematic genenmae of PHB2 of S. cerevisiae is YGR231C.; Title: strong similarity to prohibitin Phb2 -Saccharomyces cerevisiae; See PMID 9259555; See PMID 9632789; See PMID 10207067; See PMID 10835343
An12g04760	Complex: CF I in S. cerevisiae contains five subunits, Rna14, Rna15, Pcf11, Clp1 and Hrp1.; Complex: subunit of cleavage factor I (CF I).; Function: CF I is involved in pre-mRNA 3'-end processing.; Remark: the systematic genename of RNA15 of S. cerevisiae is YGL044C.; Title: strong similarity to cleavage and polyadenylation factor CF I component Rna15 - Saccharomyces cerevisiae; See PMID 11344258
An12g04770	Remark: might be a transcription factor, despite the only weak similarity to other proteins, but some motifs are present.; Title: weak similarity to helicase-like transcription factor HLTF-1 - Homo sapiens
An12g04780	Catalytic activity: NADH:ubiquinone reductase catalyzes the conversion of NADH + ubiquinone = NAD+ + ubiquinol.; Function: the 24 kD subunit of respiratory chain complex I is believed to be a component of the flavoprotein-sulfur fragment.; Title: strong similarity to 24 kD subunit of NADH:ubiquinone reductase Nuo24 - Neurospora crassa; localisation:mitochondrion
An12g04790	Title: similarity to hypothetical protein PA3762 -Pseudomonas aeruginosa
An12g04800	Catalytic activity: adenosine deaminase catalyzes the conversion of adenosine + H2O = inosine + NH3.; Pathway: adenosine deaminase is an enzyme of the purine salvage pathway.; Remark: the systenatic name of AAH1 of S. cerevisiae is YNL141W.; Title: strong similarity to adenosine deaminase Aah1 - Saccharomyces cerevisiae; See PMID 3072477; See PMID 6392474; See PMID 9335580
An12g04810	Function: SUA5 is a gene required for normal growth in S. cerevisiae.; Function: SUA5 is annotatied at the yeast databases SGD, YPD, and MIPS as being involved in translation initation.; Title: strong similarity to protein involved in translation initiation Sua5 - Saccharomyces cerevisiae; See PMID 1325384; See PMID 1666843
An12g04820	Title: strong similarity to hypothetical conserved protein SPCC132.01c - Schizosaccharomyces pombe
An12g04830	Complex: the coatomer is an oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta,epsilon and zeta subunits.; Function: the coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-ER transport of dilysine-tagged proteins.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER,via the golgi up to the trans golgi network.; Function: the coatomer zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.; Remark: the systematic name of RET3 is YPL010W.; Title: strong similarity to coatomer protein zeta chain Ret3 - Saccharomyces cerevisiae; See PMID 8617224
An12g04840	Title: similarity to hypothetical nuclear protein -Xenopus laevis
An12g04850	Title: questionable ORF
An12g04860	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L30 - Saccharomyces cerevisiae; cytoplasm
An12g04870	Function: L10 of S. cerevisiae is involved in control of cell growth and proliferation.; Remark: L10 of S. cerevisiae is also called L9, GRC5, L2341, YLR075w, or QSR1.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L10 - Saccharomyces cerevisiae; cytoplasm; See PMID 9301022
An12g04890	Title: weak similarity to proline iminopeptidase homolog MG310 - Mycoplasma genitalium
An12g04900	Remark: truncated due to end of contig.; Title: strong similarity to hypothetical protein CAE85584.1 - Neurospora crassa [truncated ORF]
An12g04910	Remark: Prp16 is an essential yeast splicing factor that catalyzes RNA-dependent hydrolysis of nucleoside triphosphates. Prp16 is a member of the DEAH-box protein family, which is defined by six co-linear sequence motifs.; Remark: might be C-terminally truncated due to contig end.; Title: strong similarity to mRNA splicing factor Prp16 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9550699; See PMID 9611193
An12g04920	Title: similarity to hypothetical protein SPCC70.11c - Schizosaccharomyces pombe
An12g04930	Similarity: shows similarity to several putative mitochondrial carrier proteins.; Title: strong similarity to hypothetical mitochondrial carrier protein SPBP23A10.06 -Schizosaccharomyces pombe; See PMID 2158156; See PMID 8206158
An12g04940	Function: in S. cerevisiae lack of functional Hsp60 did not result in increased folding, but in the aggregation of protein, suggesting that Hsp60 and Hsp70 act in an ordered pathway with substrate transfer predominantly in the direction from Hsp70 to Hsp60.; Function: protein folding in mitochondria depends on the functional cooperation of the Hsp70 and Hsp60 chaperone systems, at least for a subset of mitochondrial polypeptides.; Title: strong similarity to mitochondrial heat shock protein Hsp60 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9476895; See PMID 9563826
An12g04950	Function: F-type ATPases have 2 components, cf(1) -the catalytic core and cf(0) the membrane proton channel. cf(1) has five subunits: alpha(3), beta(3), gamma(1),delta(1), epsilon(1). cf(0) has three main subunits: a, b and c.; Function: the epsilon subunit is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial ATPase complex.; Title: strong similarity to epsilon chain of mitochondrial ATP-Synthase - Ipomoea batatas; localisation:mitochondrion; See PMID 8349605
An12g04960	Function: S. cererevisiae MAK10 is necessary for the propagation of the L-A dsRNA virus.; Function: in S. cerevisiae loss of L-A by mak10-1 mutants is partially suppressed by loss of the mitochondrial genome, suggesting that the mitochondrial genome and L-A dsRNA compete for the MAK10 protein.; Repression: S. cererevisiae MAK10 is glucose repressible.; Title: strong similarity to Mak10 - Saccharomyces cerevisiae; See PMID 1398065
An12g04970	Similarity: similarity is confined to N-terminal 50 aa containing the Zn-finger DNA-binding motif.; Title: weak similarity to zinc-finger transcription factor CAA19035.1 - Schizosaccharomyces pombe
An12g04980	Remark: ORF questionable due to short length.; Title: questionable ORF
An12g04990	Catalytic activity: D-sorbitol 6-phosphate + NAD(+) <=> D-fructose 6-phosphate + NADH.; Remark: glucitol is synonymous to sorbitol.; Title: strong similarity to glucitol 6-phosphate dehydrogenase gutD - Clostridium beijerinckii; See PMID 9572925
An12g05000	Catalytic activity: Cyclohexanone + NADPH + O(2) <=> 6-hexanolide + NADP(+) + H(2)O.; Function: chnB from Acinetobacter is a FAD monooxygenase and catalyzes the conversion of cyclohexanone to caprolactone in the cyclohexanol oxidation.; Title: strong similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 10940013
An12g05010	Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: aceA from A. awamori liberates acetic acid from wheat bran, and hydrolysed alpha-naphthyl acetate and propionate only when aromatic esters were used for the substrate.; Gene-ID: aceA;axeA; Remark: aceA from A. niger is described in Patent number EP0507369-A/7, 07-OCT-1992, GIST-BROCADES.; See PMID 9291122
An12g05020	Function: hydrophobins lower the water surface tension, coat aerial hyphae with a hydrophobic layer and mediate attachment of hyphae to hydrophobic surfaces.; Localization: HFBI from T. reesei is secreted.; Title: similarity to hydrophobin HFBI - Trichoderma reesei; See PMID 8631337; See PMID 10998570
An12g05030	Function: SKT5 from S. cerevisiae is a posttranlational activator of chitin synthase 3 activity by combining with Chs3p to interact synergistically in chitin biosynthesis.; Remark: CAL2, CHS4 and CSD4 are synonymous for SKT5.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to enzyme activator protein Skt5 - Saccharomyces cerevisiae; See PMID 9234668
An12g05040	Title: similarity to hypothetical protein lin-10 -Caenorhabditis elegans
An12g05050	Function: semi-dominant mutations in the amdA gene of E. nidulans lead to elevated expression of the gene encoding acetamidase, amdS.; Function: the C2H2 zinc-finger motifs identified in the protein of E. nidulans are similar to those found in the carbon catabolite repressor protein, CreA, which also regulates amdS and recognizes sequences which overlap with the proposed site of action for AmdA.; Localization: seems to be a nuclear protein.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297
An12g05060	Function: S. cerevisiae enzyme is a high affinity transporter of nicotinic acid.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the allantoate transporter family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10649454; See PMID 10869563
An12g05070	Function: the HHED aldolase catalyses the analogous reaction in the catechol meta-fission pathway.; Function: the homoprotocatechuic acid (HPC) pathway is a typical catabolic sequence for converting peripheral metabolites into intermediates of central metabolism.; Similarity: strong similarity at the first 2/3 of the the protein.; Title: similarity to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase hpcH - Escherichia coli; See PMID 8529896
An12g05080	Function: might be involved in regulation of translation initiation.; Similarity: predicted protein seems to be highly conserved.; Title: strong similarity to hypothetical translation initiation inhibitor SPAC922.01 - Schizosaccharomyces pombe
An12g05090	Function: 1-Aminocyclopropane carboxylase oxidase (ACC oxidase) GEFE-1 (W09880) is an enzyme involved in the biosynthesis of ethylene in plants important for fruit ripening.; Remark: blast hit against protein of patent WO9717429-A1.; Title: similarity to 1-aminocyclopropane-1-carboxylate oxidase GEFE-1 from patent WO9717429-A1 - Pelargonium domesticum
An12g05100	Remark: the enzyme of B. subtilis is used in a novel method (patent EP955375-A2) to produce optically active 4-haol-3-hydroxybutyric acid ester, with a high purity.; Similarity: seems to be highly conserved.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840
An12g05110	Title: strong similarity to hypothetical protein encoded by An15g01870 - Aspergillus niger
An12g05120	Complex: in various organisms, cdc2 has been identified as a component of the M-phase specific histone H1 kinase (maturation-promoting factor, growth-associated H1 kinase) and CTD kinase.; Function: PfPK5 of P. falciparum has kinase activity against casein and histone H1.; Function: PfPK5 of P. falciparum is present in approximately constant amounts throughout the intra-erythrocytic asexual reproductive stage of the life cycle.; Localization: PfPK5 of P. falciparum is located in the parasite's cytosol.; Similarity: shows similarity to the carboxyterminal part of cdc2 and related protein kinases.; Title: similarity to protein kinase cdc2 homolog PfPK5 - Plasmodium falciparum; deleted EC_number 2.7.1.37
An12g05140	Title: weak similarity to hypothetical protein encoded by An15g00660 - Aspergillus niger
An12g05150	Function: putative dioxygenase.; Similarity: shows similarity to several dioxygenases.; Title: similarity to protein sequence SEQ ID NO:1465 from patent WO200294867-A2 - Photorhabdus luminescens
An12g05170	Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis
An12g05180	Catalytic activity: CPEP phosphonomutase catalyzes the rearrangement of the carboxyphosphono group of CPEP to form the C-P bond of phosphinopyruvate.; Function: an enzyme catalyzing the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos (BA) was isolated from the cell extract of a mutant (NP71) of Streptomyces hygroscopicus SF1293.; Title: strong similarity to carboxyphosphonoenolpyruvate phosphonomutase bcpA -Streptomyces hygroscopicus
An12g05190	Complex: component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563
An12g05200	Function: protein of S. cerevisiae is involved in regulation of aromatic aminotransferase II that catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism.; Localization: although not found in literature,nuclear localization is highly probable.; Similarity: shows similarity to aminoterminal and central part of S. cerevisiae transcription factor.; Title: similarity to transcription factor Aro80 -Saccharomyces cerevisiae; See PMID 10207060
An12g05210	Function: in lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium.; Function: trout MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA).; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446
An12g05220	Function: the nmt1+ gene of the fission yeast Schizosaccharomyces pombe is subject to transcriptional repression mediated by thiamine and ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter.; Similarity: shows only similarity to the amino- and central part of nft1.; Title: similarity to transcription factor nft1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491
An12g05240	Title: weak similarity to RNA polymerase -Paramyxoviridae sp.
An12g05250	Similarity: shows only weak similarity to aminoterminal and central part of TH7 protein and also to parts of several patented proteins.; Title: weak similarity to phenylcoumaran benzylic ether reductase homolog TH7 - Tsuga heterophylla; See PMID 10066819
An12g05260	Catalytic activity: hydroxyisoflavone reductases catalyse vestitone + NADP(+) <=> 2'-hydroxyformononetin + NADPH.; Function: hydroxyisoflavone reductases are involved in the biosysthesis of the pterocarpin phytoalexins medicarpin and maachiain, which play a significant role in the defense response of plants.; Similarity: strong similarity to Sequence 17 from Patent EP0845532, which decribes enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications.; Title: similarity to 2-hydroxyisoflavone reductase -Pisum sativum; See PMID 10680168
An12g05270	Remark: only the N-terminal domain of the protein is matching.; Similarity: to Zn(2)-Cys(6) binuclear cluster family.; Title: weak similarity to transcription activator CMR1 - Colletotrichum lagenarium
An12g05280	Remark: esterases are contributing to detoxification of pyrethroid compounds, as a resistant mechanism in Mexican strains of the southern cattle tick.; Title: weak similarity to esterase - Boophilus microplus; See PMID 10899463
An12g05290	Title: weak similarity to hypothetical protein encoded by An04g00640 - Aspergillus niger
An12g05310	Remark: possibly involved in the degradation of external UDP-glucose by similarity; Similarity: belongs to 5' nucleotidase family.; Title: strong similarity to hypothetical 5 nucleotidase family protein SPBPB2B2.06c -Schizosaccharomyces pombe
An12g05320	Title: similarity to hypothetical protein encoded by An09g02090 - Aspergillus niger
An12g05330	Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: some chitinases also display lysozyme activity.; Similarity: to protein with hevein chitin-binding domain homology.; Title: strong similarity to RF2 - Candida sphaerica; See PMID 6387625; See PMID 6473099
An12g05360	Remark: cholesterol 24-hydroxylase is expressed predominantly in the brain as judged by RNA and protein blotting. In situ mRNA hybridization and immunohistochemistry localize the expression of this P450 to neurons in multiple subregions of the brain.; Remark: the turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma.; Similarity: belongs to cytochrome P450 family proteins.; Title: strong similarity to cholesterol 24-hydroxylase - Mus musculus; See PMID 10377398
An12g05370	Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913
An12g05380	Remark: confer resistance to various antibiotics and toxins in fungi and bacteria.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Title: strong similarity to cercosporin transporter CFP - Cercospora kikuchii; See PMID 10517030
An12g05390	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An12g05400	Catalytic activity: cholesterol + NADPH + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O.; Pathway: bile acid biosynthesis.; Remark: cholesterol 7 alpha-hydroxylase, the key enzyme in a series of metabolic changes for the production of bile acids from cholesterol, shows circadian rhythms.; Similarity: belongs to the human cytochrome P450 family.; Title: similarity to cholesterol 7alpha-monooxygenase CYP7 - Oryctolagus cuniculus; See PMID 7751825
An12g05420	Title: similarity to hypothetical protein encoded by An03g01830 - Aspergillus niger
An12g05430	Title: similarity to hypothetical protein CAF32108.1 - Aspergillus fumigatus
An12g05440	Induction: by allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.; Remark: DUR3 expression in yeast is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; See PMID 8335627
An12g05450	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An12g05460	Catalytic activity: ATP + 5-oxo-L-proline + 2 H2O = ADP + orthophosphate + L-glutamate.; Pathway: 5-OPase of R. norvegicus is involved in glutathione biosynthesis.; Phenotype: deficiency of 5-OPase of R. norvegicus is associated with 5-oxoprolinuria.; Remark: 5-OPase of R. norvegicus belongs to the oxoprolinase family.; Title: strong similarity to 5-oxoprolinase from patent WO9825945-A1 - Rattus norvegicus; See PMID 8943290; See PMID 9516961; See PMID 9751079
An12g05470	Similarity: the ORF shows strong local similarity to yraM of B. subtilis along the N-terminal half.; Title: strong similarity to hypothetical protein yraM - Bacillus subtilis
An12g05490	Similarity: the N-terminus of the ORF shows strong similarity to several other proteins including transcription factors.; Title: similarity to hypothetical protein encoded by An01g03400 - Aspergillus niger
An12g05500	Function: dsk1 of S. pombe plays a role in the regulation of chromosome segregation at the metaphase/anaphase transition.; Function: recently, it was found that dsk1 of S. pombe also functions as a kinase specific for SR proteins,a family of pre-mRNA splicing factors containing arginine-serine repeats, and is thus presumably involved in pre-mRNA splicing.; Remark: dsk1 (dis1-suppressing protein kinase) of S. pombe is also called SPBC530. 14C.; Similarity: the ORF is shorter than dsk1 of S. pombe (307 compared to 455 amino acids).; Similarity: the ORF shows local strong similarity to dsk1 of S. pombe over two stretches of ca. 100 and ca. 60 amino acids.; Title: similarity to protein kinase dsk1p -Schizosaccharomyces pombe; See PMID 9488736; See PMID 10629038
An12g05510	Function: TAF1 of S. cerevisiae encodes a transporter for the fungal siderophore triacetylfusarinine C.; Phenotype: disruption of TAF1 of S. cerevisiae leads to yeast cells unable to take up and utilize iron from triacetylfusarinine C und fusigen.; Remark: TAF1 is also called ARN2 or YHL047c.; Remark: siderophores (e. g. ferrioxamine B,ferrichrome, triacetylfusarinine C and ferricrocin) are iron chelators and are used by bacteria to bind extracellular iron. After iron binding they are recognized by membrane proteins such as TAF1 and the bound iron is internalized.; Title: strong similarity to triacetylfusarinine C transporter Taf1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10816729; See PMID 11158346; See PMID 2531838
An12g05520	Remark: the ORF has an unusual exon/intron structure for A. niger.
An12g05530	Remark: the ORF has an unusual exon/intron structure for A. niger.
An12g05570	Function: faoA of A. terreus is an FAD-binding oxidoreductase, which deglycates glycated compounds like N-epsilon-fructosyl N-sigma-Z-lysine and N-fructosyl valine, oxidatively into free fructosamine.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 9022674
An12g05580	Remark: the ORF is shorter than SPBC530. 11c of S. pombe (514 compared to 819 amino acids).; Similarity: the ORF shows local similarity to SPBC530. 11c of S. pombe over a stretch of 260 amino acids.; Title: weak similarity to hypothetical transcriptional regulator SPBC530.11c - Schizosaccharomyces pombe
An12g05590	Catalytic activity: B. subtilis pnbA catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acids and PNB alcohols.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An12g05600	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Similarity: the ORF is about 100 amino acids shorter than het-6 of N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An12g05610	Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system and belongs to the Amino Acid/Auxin Permease (AAAP)family (TC 2. A. 42).; Remark: mtr is a short cut for methyltryptophan resistance (protein).; Title: strong similarity to neutral amino acid permease mtr from patent WO9325663-A - Neurospora crassa; plasma membrane; See PMID 8001794; See PMID 1838345
An12g05630	Function: TRI101 of F. sporotrichioides confers resistance to the trichothecene 4,15-diacetoxyscirpenol.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of the trichothecene T-2 toxin.; Phenotype: mutation of TRI101 of F. sporotrichioides leads to abolished synthesis of T-2 toxin and to accumulation of isotrichodermol.; Remark: fungi protect themselves from their own toxins by e. g. modification of the toxins.; Remark: trichothecenes are mycotoxins and act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; See PMID 10960733
An12g05640	Similarity: the ORF is much shorter than Y57A10A. p of C. elegans (364 compared to 1718 amino acids).; Title: weak similarity to hypothetical protein Y57A10A.p - Caenorhabditis elegans
An12g05650	Function: ankyrins serve as linkers between the spectrin-based cytoskeleton and integral membrane protein.; Localization: ank3 of M. musculus is plasma-membrane associated.; Remark: the ORF shows local similarity to ank3 of M. musculus (about 500 C-terminal amino acid of the ORF are aligned with ank3); the ank motifs are included in the alignment between the two proteins.; Title: strong similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 7615634; See PMID 10810176
An12g05660	Title: similarity to hypothetical protein encoded by An12g02830 - Aspergillus niger
An12g05670	Title: similarity to protein fragment SEQ ID NO:19345 from patent EP1033405-A2 - Arabidopsis thaliana [putative frameshift]; putative frameshift
An12g05680	Function: ANK1 is a cytoskeleton component and generates the p57 membrane proteinase which cleaves C3, the third component of complement.; Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens; plasma membrane; See PMID 7526850; See PMID 2141335
An12g05700	Catalytic activity: RhaA is able to hydrolyze alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Title: similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105
An12g05710	Catalytic activity: fucP has L-fucose-H+ symport activity.; Function: fucP mediates the transport of L-Fucose (6-deoxy-L-galactose) into Escherichia coli.; Title: strong similarity to L-fucose permease fucP -Escherichia coli; plasma membrane; See PMID 8052131
An12g05720	Pathway: heml is involved in porphyrin and chlorophyll metabolism.; Remark: Deletion of heml does not ablate heme biosynthesis.; Remark: the Bacillus subtilis hemAXCDBL gene cluster encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III.; Title: strong similarity to glutamate-1-semialdehyde 2,1-aminomutase hemL - Bacillus subtilis [putative frameshift]; putative frameshift; See PMID 1672867
An12g05730	Title: weak similarity to hypothetical protein encoded by An08g11010 - Aspergillus niger
An12g05740	Title: strong similarity to hypothetical protein EAA70268.1 - Gibberella zeae
An12g05750	Function: PHO84 is a high-affinity inorganic phosphate/H+ symporter.; Induction: PHO84 transcription is regulated by Pi.; Phenotype: disruption of PHO84 is not lethal.; Title: strong similarity to high-affinity inorganic phosphate/H+ symporter Pho84 - Saccharomyces cerevisiae; plasma membrane; See PMID 10518922; See PMID 2038328
An12g05780	Title: questionable ORF
An12g05790	Title: questionable ORF
An12g05800	Title: questionable ORF
An12g05810	Catalytic activity: laccases convert 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Function: laccase (urishiol oxidase) is an multi-copper enzyme found in fungi and plants with low specificity on both catechol and p-benzenediol, which oxidizes many different types of phenols and diamines.; Function: laccase of C. parasitica is involved in the lignin degradation an detoxification of lignin-derived products.; Induction: copper is needed as cofactor.; Remark: the A. nidulans homologue of the ORF encodes a dihydrogeodin oxidase, that catalyzes the regio- and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin.; Similarity: shows similarity to several laccases,phenol oxidases of different organisms.; Title: strong similarity to laccase - Cryphonectria parasitica; See PMID 3032923; See PMID 7665560; See PMID 1535523
An12g05820	Phenotype: HGT1 disruption strains show much-reduced uptake of glucose at low concentrations and growth are particularly affected in low-glucose medium.; Similarity: HGT1 belongs to the sugar transporter family.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An12g05830	Title: weak similarity to transcription regulator PRO1 - Sordaria macrospora
An12g05840	Function: E1 is involved in lipid metabolism and in the detoxification of xenobiotics.; Remark: possible sequencing error at position 51887,2 bp too much.; Title: similarity to precursor of liver carboxylesterase E1 - Rattus norvegicus [putative frameshift]; endoplasmatic reticulum; putative frameshift; See PMID 2973315; See PMID 3235453; See PMID 8006016
An12g05870	Induction: mmsR has been identified as a member of the XylS/AraC family of transcriptional regulators and appears to act as a positive regulator of the mmsAB operon.; Remark: mmsB belongs to the mmsAB operon of Pseudomonas aeruginosa PAO containing two structural genes involved in valine metabolism.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa; See PMID 1339433
An12g05890	Title: weak similarity to outer spore coat protein cotB - Bacillus subtilis
An12g05900	Remark: Prt1 activity is inhibited by phenanthroline, suggesting that it is a metalloprotease.; Title: strong similarity to extracellular metalloproteinase precursor Prt1 - Erwinia carotovora; extracellular/secretion proteins; See PMID 1917878
An12g05920	Title: weak similarity to negative regulatory protein Hex2 - Saccharomyces cerevisiae
An12g05930	Title: similarity to hypothetical protein SPCC970.02 - Schizosaccharomyces pombe
An12g05950	Similarity: the central part produces deliberate homology matches with a variety of serine/threonine-rich glycoproteins.; Title: weak similarity to hypothetical protein YMR317w - Saccharomyces cerevisiae
An12g05960	Catalytic activity: DPPII of R. norvegicus hydrolyzes the peptide bond between the second and third amino acid residue of oligo- and polypeptides,preferentially those following a proline residue.; Complex: DPPII of R. norvegicus probably forms a homodimer by means of a leucine zipper motif.; Function: DPPII of R. norvegicus is involved in the degradation of some oligopeptides or their fragments, such as substance P, casomorphin, bradykinin and thyroliberin.; Similarity: DPPII of R. norvegicus belongs to the serine protease superfamily.; Similarity: DPPII of R. norvegicus shares strong homology with human quiescent cells proline dipeptidase QPP.; Similarity: shows also strong similarity to the Haem 84-1 portion of H. contortus 55A surface protein of patent GENESEQPROT:R12098.; Similarity: the 3'-part of the ORF shows strong similarity to a 3'-EST of the A. niger cDNA clone 0418 (EMBLEST:BE760748).; Title: strong similarity to dipeptidyl peptidase II DPPII - Rattus norvegicus; lysosome; See PMID 11139392; See PMID 11173530
An12g05970	Catalytic activity: NahW of P. stutzeri is a NADH-dependent monooxygenase that catalyzes the conversion of salicylate to catechol.; Function: NahW of P. stutzeri is an isoenzyme of the NahG salicylate hydroxylase.; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An12g05990	Similarity: the central part also shares similarity with the serine/threonine-rich domain of the cell wall maintanance and heat response related protein WSC2 of S. cerevisiae.; Title: weak similarity to hypothetical protein AAA19110.1 - Pichia angusta
An12g06010	Catalytic activity: PAO of Z. mays catalyzes the FAD-dependent oxidation of secondary amino groups of spermidine and spermine and their acetyl derivatives,thereby producing hydrogen peroxide.; Function: PAO in Z. mays plays an impotant role in the homeostasis of polyamines which are involved in cell growth and differentiation.; Localization: plant PAOs are predominantly localised in the cell wall.; Pathway: PAO of Zea mays is a key enzyme in the polyamine catabolism.; Remark: possible frameshift at position 10905.; Title: strong similarity to polyamine oxidase PAO -Zea mays [putative frameshift]; putative frameshift; See PMID 9598979; See PMID 11164591
An12g06030	Catalytic activity: sulfite oxidase of G. gallus catalyzes the reaction 'sulfite + H2O + O2 = sulfate + H2O2'.; Complex: sulfite oxidase of G. gallus is a homodimer.; Function: sulfite oxidase of G. gallus contains a cytochrome b-like heme-binding domain and a molybdopterin-binding domain.; Function: the catalytic activity of sulfite oxidase of G. gallus requires molybdenum.; Localization: sulfite oxidase of G. gallus is localized to the mitochondrial intermembrane space.; Pathway: sulfite oxidase of G. gallus catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine.; Remark: in the presence of cytochrome c sulfite oxidase of G. gallus transfers the electrons on cytochrom c and not on oxygen.; Similarity: the A. niger protein also shows strong similarity to various bacterial sulfite dehydrogenases (EC 1. 8. 2. 1) involved in lithotrophic sulfur oxidation.; Title: strong similarity to sulfite oxidase - Gallus gallus; localisation:mitochondrion; See PMID 510290; See PMID 2687265; See PMID 9428520
An12g06040	Catalytic activity: ACC synthase catalyzes the reaction 'S-adenosylmethionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine'.; Function: ACC synthase is a critical regulatory enzyme for ethylene dependent development processes such as fruit ripening and flower senescence and response to various environmental stimuli.; Function: ACC synthase requires pyridoxal phosphate as a prosthetic group.; Pathway: ACC synthase is the key enzyme in the biosynthesis of the plant hormone ethylene.; Remark: possible sequence error leading to a premature STOP at position 15543.; Similarity: the A. niger gene shows strong similarity to the protein patent database entry GENESEQPROT:W57484.; Title: strong similarity to 1-aminocyclopropane-1-carboxylic acid synthase from patent US5767376-A - Carica papaya [putative sequencing error]; putative sequencing error; See PMID 9449850; See PMID 10889246; See PMID 7891663
An12g06050	Function: Flr1p of S. cerevisiae confers resistance to various antibiotics including fluconazole, diazaborine,cerulenin, benomyl and methotrexate.; Function: Flr1p of S. cerevisiae participates in the Yap1p-mediated oxidative stress response.; Induction: FLR1 expression in S. cerevisiae is transcriptionally activated by the bZip transcription factor Yap1p.; Remark: the systematic name of FLR1 of S. cerevisiae is YBR008c.; Similarity: FLR1 of S. cerevisiae belongs to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10102370; See PMID 10572257; See PMID 10903515; See PMID 11056165
An12g06060	Title: similarity to hypothetical protein AAK28431.1 - Streptococcus gordonii
An12g06070	Function: AflR in A. flavus is required for the expression of the nor1 and ver1 genes.; Pathway: AflR in A. flavus is involved in the regulation of aflatoxin biosynthesis.; Similarity: AflR of A. flavus encodes a putative transcription factor containing a Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Similarity: the homology is limited to the N-terminus containing the Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Title: similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus; See PMID 8074521
An12g06090	Title: similarity to hypothetical 12.8K protein G3L - Vaccinia virus
An12g06100	Similarity: also shows weak similarity to the N-terminal part of human dentatorubral-pallidoluysian atrophy protein DRPLA (atrophin-1).; Title: weak similarity to hypothetical precursor of extensin - Lycopersicon esculentum
An12g06110	Title: similarity to hypothetical protein encoded by An03g04820 - Aspergillus niger
An12g06120	Similarity: AAB98428. 1 of M. jannaschii is a homolog of the conserved hypothetical protein HI0902 from Haemophilus influenzae.; Title: weak similarity to hypothetical protein AAB98428.1 - Methanococcus jannaschii
An12g06130	Title: similarity to glutamyl endoprotease polypeptide from patent WO200268623-A2 - Aspergillus niger
An12g06140	Remark: the ORF is N-terminally truncated due to the end of the contig.; Similarity: the N-terminal part of the truncated ORF produces deliberate homology matches to a variety of proline-rich proteins from diverse species.; Title: similarity to hypothetical protein encoded by An16g07930 - Aspergillus niger [truncated ORF]
An12g06180	Catalytic activity: GnT-IV generates the beta-1,4-glycosidic bond between a N-acetylglucosamin moiety (from GlcNAc-UDP) and the alpha-1,3-linked Mannose residiue of the biantennary core structure of N-glycans (Man3GlcNAc2-Asn).; Function: GnT-IV is one of the essential enzymes in the production of tri- and tetra-antennary Asn-linked sugar chains.; Function: MGAT4B of H. sapiens has GnT-IV enzymatic activity.; Title: weak similarity to isoenzyme B of UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV MGAT4B - Homo sapiens; See PMID 10372966; See PMID 9278430; See PMID 9565571
An12g06190	Function: acu-15 in N. crassa is involved in the regulation of acetate induction.; Similarity: the similarity is restricted to the N-terminal part.; Title: weak similarity to transcription activator acu-15 - Neurospora crassa
An12g06200	Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An12g06210	Title: similarity to hypothetical protein encoded by An11g09010 - Aspergillus niger
An12g06240	Title: weak similarity to hypothetical protein AAL32543.1 - Arabidopsis thaliana
An12g06250	Function: the secreted protein of patent Y11086 may be useful for treating or reducing the risk of H. pylori infections.; Similarity: shows weak similarity to the protein patent database entry GENESEQPROT:Y11086.; Title: weak similarity to secreted protein from patent WO9824475-A1 - Helicobacter pylori
An12g06270	Title: weak similarity to hypothetical caspase-8 CASP8 - Rattus norvegicus
An12g06280	Similarity: the sequence of residues 79 to 123 is similar to the repeat sequence of autolysin from Enterococcus faecalis (PubMed 1679432; patent GENESEQPROT:R85290).
An12g06290	Catalytic activity: KlDLD in K. lactis catalyzes the stereospecific oxidation of D-lactate to pyruvate: (R)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c.; Function: KlDLD of K. lactis transfers two electrons from D-lactate to cytochrome c via FAD.; Induction: KlDLD in K. lactis is induced by it's substrate lactate at the transcriptional level.; Pathway: KlDLD of K. lactis is the key enzyme of D-lactate utilization which is linked to the respiratory chain.; Repression: KlDLD in K. lactis is repressed by glucose at the transcriptional level.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9683671; See PMID 7969031
An12g06300	Function: LovC of A. terreus encodes a putative enoyl reductase.; Similarity: contains a Zn-binding dehydrogenases similarity domain.; Similarity: the 5'-part of the ORF shows similarity to a 5'-EST of the A. niger cDNA clone 3213 (EMBLEST:BE758951).; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An12g06310	Title: weak similarity to hypothetical protein MGD8.2 - Arabidopsis thaliana
An12g06340	Function: the human erythrocyte ankyrin ANK1 attachs integral membrane proteins to cytoskeletal elements. It binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein.; Title: similarity to erythrocyte ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 1689849; See PMID 8226993; See PMID 8640229
An12g06350	Title: weak similarity to glucan synthase FKS -Paracoccidioides brasiliensis
An12g06360	Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to transamidase GPI8 -Plasmodium falciparum
An12g06380	Function: fibroin heavy chain Fib-H from Bombyx mori (domestic silkworm) forms the silk filament; a strong,inextensible, insoluble and chemically inert fibre.; Remark: Bombyx mori=domestic silkworm.; Remark: the structure of the ORF encoded protein is highly repetitive.; Title: similarity to fibroin heavy chain Fib-H -Bombyx mori; extracellular/secretion proteins; See PMID 10366732
An12g06400	Function: recombinant Nor-1 from A. parasiticus expressed in E. coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH. The results confirm that Nor-1 functions as a ketoreductase in vitro.; Pathway: the Nor-1 ketoreductase from A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 10584035; See PMID 7993094
An12g06420	Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to gag-like protein protein from transposon TART-B1 - Drosophila melanogaster [truncated ORF]; See PMID 7809068
An12g06430	Title: strong similarity to reverse transcriptase of the LINE-like retrotransposon Tad1-1 - Neurospora crassa; See PMID 7512193
An12g06440	Function: Lovastatin is a fungal polyketide derived metabolite isolated from a strain of Aspergillus terreus,which inhibits the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase an enzyme involved as key rate-controlling step early in the cholesterol biosynthetic pathway.; Title: strong similarity to transesterase involved in the lovastatin biosynthesis LovD - Aspergillus terreus; See PMID 10334994
An12g06460	Title: similarity to hypothetical protein CG10383 -Drosophila melanogaster
An12g06470	Title: weak similarity to AP1 protein from patent US5811536-A - Arabidopsis thaliana
An12g06480	Function: the AmdA transcriptional activator from A. nidulans is involved in the induction of the A. nidulans structual gene amdS (acetamidase).; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An12g06490	Cofactor: the cofactor from human FMO1 enzyme is FAD.; Function: the human hepatic monooxygenase FMO1 is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. FMO1 catalyzes the N-oxygenation of secondary and tertiary amines.; Title: similarity to N-oxide-forming dimethylaniline monooxygenase FMO1 - Homo sapiens; See PMID 8128486; See PMID 1712018
An12g06500	Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: the ORF encoded protein shows also strong similarity to the allantoate transporter Dal5/YJR152W from S. cerevisiae, but the accessible literature does not describe any functional characterization of Dal5 (Pubmed 3275614).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An12g06510	Function: the gibberellin 7-oxidase from Cucurbita maxima is a 2-oxoglutarate dependent dioxygenase involved in final steps of gibberellin (GA) plant hormones biosynthesis.; Pathway: Gibberellin (GA) plant hormones biosynthesis.; Similarity: the ORF shows similarity to several putative oxidoreductases.; Similarity: the gibberellin 7-oxidase from Cucurbita maxima (winter squash) belongs to the superfamily of the 1-aminocyclopropane-1-carboxylate oxidases.; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256
An12g06520	Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Remark: the esterase described in patent JP11075860-A is identical to the arylesterase from Acetobacter pasteurianus EST1; Title: similarity to esterase from patent JP11075860-A - Acetobacter pasteurianus
An12g06530	Catalytic activity: (S)-lactate + 2 ferricytochrome C <=> pyruvate + 2 ferrocytochrome C.; Cofactor: FMN; Protoheme IX.; Complex: Homotetramer.; Localization: the flavocytochrome b2 L-lactate dehydrogenas CYB2 from Pichia anomala is located in the mitochondrial intermembrane space.; Remark: Pichia anomala=Hansenula anomala.; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala; localisation:mitochondrion; See PMID 2688640; See PMID 3319613
An12g06540	Title: similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa
An12g06550	Title: similarity to hypothetical protein encoded by An01g11860 - Aspergillus niger
An12g06560	Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Title: strong similarity to triacylglycerol lipase Lip4 - Candida rugosa; See PMID 8440480; See PMID 10787175
An12g06580	Remark: Inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Remark: amdR genes are highly conserved and functionally interchangeable between species.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021; See PMID 2188110
An12g06590	Title: similarity to essential gene #7448 from patent WO200277183-A2 - Burkholderia fungorum
An12g06610	Title: weak similarity to mitogen-activated protein kinase MKC1 - Candida albicans; See PMID 7891715
An12g06630	Title: weak similarity to hypothetical protein F17K2.5 - Arabidopsis thaliana
An12g06640	Remark: Cdc48p of S. cerevisiae is more than twice the length of this protein.; Remark: the Yeast cell cycle protein CDC48p is a member of a protein family involved in secretion,peroxisome formation, and gene expression.; Title: weak similarity to valosin-containing protein like AAA-ATPase Cdc48 - Saccharomyces cerevisiae; See PMID 9695811; See PMID 1860879
An12g06650	Remark: similarity to dnaJ proteins belongs only to the dnaJ motif.; Title: weak similarity to hypothetical surface-located membrane protein 1 lmp1 - Borrelia burgdorferi
An12g06660	Title: strong similarity to hypothetical protein encoded by An11g03400 - Aspergillus niger
An12g06670	Title: similarity to hypothetical protein encoded by An08g12240 - Aspergillus niger
An12g06680	Title: similarity to hypothetical protein slr0852 -Synechocystis sp.
An12g06690	Catalytic activity: Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine + a Carboxylate.; Remark: the homology is only at the C-terminal part.; Remark: the normal cofactor of this enzyme class is calcium.; Remark: the phospholipase A(2) (PLA(2)) superfamily consists of a broad range of enzymes defined by their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate phospholipids.; Title: similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412; See PMID 11080672
An12g06710	Remark: match found in blastXpatent analysis.; Title: weak similarity to ApoE4Lx2 protease from patent WO9413798-A - Homo sapiens
An12g06720	Remark: N-terminal truncated orf due to end of contig.; Remark: only weakly conserved PFAM motif (PF00069 Eukaryotic protein kinase domain), but this ORF can probably be considered as having this domain; compare to the PFAM results,; Remark: shows weak similarity to several serine/threonine protein kinases.; Title: weak similarity to translation initiation factor eIF-2 alpha kinase GCN2 - Drosophila melanogaster [truncated ORF]
An12g06730	Title: weak similarity to metalloreductase freA -Aspergillus nidulans
An12g06740	Title: similarity to hypothetical protein encoded by An12g06730 - Aspergillus niger
An12g06760	Remark: the protein shows weak similarity to the mlr9023 transposase sequences of Mesorhizobium loti within the aminoacid sequence 89-148.
An12g06770	Remark: co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Remark: the A. niger gene is only one half of the lenght of the P. anserina protein.; Remark: the het-e-1 gene of the fungus Podospora anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787
An12g06780	Title: similarity to hypothetical protein encoded by An04g07590 - Aspergillus niger
An12g06800	Title: weak similarity to hypothetical protein encoded by An04g07590 - Aspergillus niger
An12g06830	Title: strong similarity to hypothetical protein encoded by An11g08100 - Aspergillus niger
An12g06840	Title: similarity to hypothetical protein encoded by An02g09280 - Aspergillus niger
An12g06850	Title: similarity to hypothetical protein encoded by An12g06870 - Aspergillus niger
An12g06860	Title: strong similarity to hypothetical protein 68B2.10 - Neurospora crassa
An12g06870	Title: similarity to hypothetical protein encoded by An12g06850 - Aspergillus niger
An12g06890	Remark: the schistosome homologues of heat-shock protein Hsp70 elicit a dominant antibody response in humans infected with S. mansoni.; Title: strong similarity to dnaK-type molecular chaperone hsp70 - Schistosoma mansoni; See PMID 1484560
An12g06900	Remark: ORF 5' truncated due to end of contig.; Title: weak similarity to DNA gyrase B subunit gyrB - Flexibacter japonensis [truncated ORF]
An12g06910	Similarity: similarity from predicted A. niger protein is to the N-terminus of C. thermosaccharolyticum xylose isomerase, which is 350 aa longer.; Title: weak similarity to xylose isomerase -Clostridium thermosaccharolyticum
An12g06920	Title: weak similarity to NAD-dependent DNA ligase -Thermus sp.
An12g06930	Catalytic activity: alpha-amylases catalyse the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Gene-ID: amyA;amyB; Remark: nearly identical matches (even on DNA level) were found to other ORFs.; Remark: the A. niger transposon Ant1 is known to contain amyA 3'UTR sequences, therefore the genomic localization of the predicted A. niger protein could be due to a transposon induced rearrangment.; Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: the nucleotide sequences of amyA and amyB from A. niger are identical throughout all but the last few nucleotides of their respective coding regions.; See PMID 2340591
An12g06940	Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposon insertion.; Remark: the central region of the A. niger transposon Ant1 contains the 3' UTR of the amyA from A. niger.; Remark: the predicted A. niger protein shows strong similarity on DNA level to the 3' UTR of amyA from A. niger.; Title: strong similarity to hypothetical protein encoded by An05g02110 - Aspergillus niger; See PMID 8552048
An12g06960	Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: similarity is from C-terminal 100 aa of the predicted A. niger protein to N-terminus of PDC E1 alpha from A. thaliana.; Title: weak similarity to E1 alpha subunit of pyruvate dehydrogenase complex PDC - Arabidopsis thaliana; See PMID 7590338
An12g06970	Complex: other domains of S. cerevisiae Djp1p interact with the substrates for the Hsp70 machinery.; Complex: the DnaJ-domain of S. cerevisiae Djp1p specifies the interaction with a particular Hsp70.; Function: S. cerevisiae Djp1p in conjunction with hsp70 proteins is specifically required for peroxisomal protein import.; Remark: YIR004w is the systematic name for S. cerevisiae Djp1p.; Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: similarity of predicted A. niger protein is confined to N-terminal half of S. cerevisiae Djp1p which is 200 aa longer.; Title: similarity to DnaJ-like protein Djp1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9679141
An12g06980	Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Title: strong similarity to EST SEQ ID NO:6341 from patent WO200056762-A2 - Aspergillus oryzae
An12g06990	Remark: the adjacent genomic region contains several transposon related sequences, indicating a hotspot for transposon insertion.; Similarity: the predicted A. niger protein is only a 100 aa remnant of the 1230 aa reverse transcriptase homologe from C. intestinalis.; Title: similarity to hypothetical reverse transcriptase homolog - Ciona intestinalis
An12g07000	Function: ORF1 of A. niger Ant1 encodes the Ant1 transposase.; Remark: in the adjacent genomic region only remnants of the complete Ant1 transposon are found on both DNA strands, spaced from base 55168 to 63290.; Remark: the adjacent genomic region contains several transposon related sequences, indicating a hotspot for transposon insertion.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048
An12g07020	Complex: S. cerevisiae Hoc1 together with Anp1, Mnn9, Mnn10, and Mnn11 forms the Golgi mannosyltransferase A-complex.; Function: S. cerevisiae HOC1 has been suggested to encode a Golgi-localized putative mannosyltransferase required for the proper construction of the cell wall.; Function: S. cerevisiae Hoc1 is a component of the Golgi mannosyltransferase A-complex, which also shows protein O-glycosylation activity.; Golgi; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 10635561
An12g07030	Function: S. cerevisiae Wsc proteins are putative transmembrane stress receptors and upstream activators of the RHO1-regulated PKC1-MAP kinase cascade.; Function: S. cerevisiae Wsc proteins are required for maintenance of cell wall integrity and the stress response.; Remark: YOL105c is the systematic name for WSC3.; Similarity: the predicted A. niger protein contains predicted WSC- and transmembrane domains.; Title: weak similarity to stress response mediator Wsc3 - Saccharomyces cerevisiae; See PMID 10394905; See PMID 10430578
An12g07040	Remark: ORF questionable due to short length and nearly entirely consisting of lysine.; Similarity: ORF shows unspecific similarity to lysine rich proteins.; Title: questionable ORF
An12g07050	Remark: 5' of this predicted A. niger protein is an ORF which also shows similarity to the N-terminal region of drf1, possibly indicating a gene duplication.; Similarity: the similarity of the predicted A. niger protein is to the N-termnal region of S. pombe dfr1, while the conserved dihydrofolate reductase domain is at the C-terminus of dfr1.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538
An12g07060	Remark: coincidentally the ORF 3' of this predicted A. niger protein itself shows similarity to dfr1 of S. pombe indicating a possible gene duplication.; Remark: the hypothetical protein YMR222c of S. cerevisiae shows similarity to dihydrofolate reductase dfr1 of S. pombe.; Title: similarity to hypothetical protein YMR222c -Saccharomyces cerevisiae
An12g07070	Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776
An12g07090	Function: 6-HDNO of A. oxidans specifically oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Remark: at position 37530 a possible sequencing error was corrected.; Similarity: the predicted A. niger protein shows similarity to several oxygen oxidoreductases that covalently bind FAD.; Similarity: the similarity between the predicted A. niger protein and 6-HDNO from A. oxidans is confined to the FAD binding domain.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans [putative sequencing error]; putative sequencing error; See PMID 2115879; See PMID 3622516
An12g07100	Function: cucumopine synthase produces cucumopine, a guanido amino acid of unknown function.; Remark: no literature was available also a Genbank entry from 08-SEP-2000 contains a 'in press' statement.; Title: strong similarity to cucumopine synthase cus - Agrobacterium rhizogenes
An12g07110	Catalytic activity: the anthranilate synthase complex catalyses the reaction, Chorismate + L-glutamine <=> anthranilate + pyruvate + L-glutamate.; Function: Y. pestis YbtS is part of the anthranilate synthase complex, which can be involved in the biosynthesis of tryptophan.; Function: Y. pestis YbtS might be necessary for converting chorismate to salicylate.; Title: strong similarity to anthranilate synthase component I ybtS - Yersinia pestis; See PMID 9818149
An12g07120	Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains in a multitude of biochemical pathways. .; Similarity: the C-terminus of the predicted A. niger protein contains a conserved P450 monooxygenase domain.; Title: similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 9917370
An12g07130	Title: strong similarity to hypothetical protein cipA - Aspergillus nidulans
An12g07140	Function: Rdr1 from S. cerevisiae acts as a transcriptional repressor of multiple genes.; Similarity: the N-terminal region of the predicted A. niger protein contains a GAL4-type Z(2)-Cys(6) DNA-binding domain.; Title: strong similarity to zinc-finger transcription factor Rdr1 - Saccharomyces cerevisiae; nucleus; See PMID 11882665
An12g07150	Function: R. etlic NifA is a transcriptional regulator of nitrogen fixation.; Similarity: the predicted A. niger protein shows similarity to a domain of the transcriptional regulator NifA from R. etli required for RNA pol-II sigma-54 factor interaction and ATP-binding.; Title: weak similarity to NIF-specific regulatory protein NIFA - Rhizobium etli; See PMID 9560416
An12g07160	Similarity: predicted A. niger protein contains a C-terminal putative ATPase domain and shows similarity to several ATPase domain containing proteins.; Similarity: similarity of predicted A. niger protein is between its C-terminus and the C-terminal ATPase domain of myosin heavey chain of G. gallus.; Title: weak similarity to myosin heavy chain -Gallus gallus
An12g07170	Function: S. cerevisiae DUR3 is a urea symporter mediating urea import.; Induction: High-level expression of S. cerevisiae DUR3 is inducer dependent, requiring functional DAL81 and DAL82 genes.; Regulation: Expression of S. cerevisiae DUR3 is regulated in a manner similar to that of other genes in the allantoin pathway.; Repression: DUR3 expression is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Repression: Maintenance of S. cerevisiae DUR3 mRNA at uninduced, nonrepressed basal levels requires the negatively acting DAL80 gene product.; Similarity: S. cerevisiae DUR3 belongs to the major facilitator family.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8335627
An12g07180	Function: SalE of Acinetobacter sp. was shown to have esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An12g07190	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Remark: the predicted A. niger protein is C-terminal 200 aa shorter than nirA of A. nidulans.; Similarity: nirA of A. nidulans belongs to the family of Gal4 Zn(2)-Cys(6)-finger transcription factors.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1922075
An12g07200	Title: weak similarity to hypothetical seryl-tRNA synthase APE1976 - Aeropyrum pernix
An12g07210	Remark: the predicted A. niger protein shows similarity to the N-terminal region of S. cerevisiae YML002w, which is 550 aa longer.; Title: weak similarity to hypothetical membrane protein YML002w - Saccharomyces cerevisiae
An12g07220	Similarity: similarity is confined to N-terminal region.; Title: weak similarity to antibacterial glycoprotein achacin - Achatina fulica; See PMID 1396687
An12g07230	Function: the S. chrysomallus actinomycin synthetases ACMS I, II, and III catalyze the assembly of the acyl peptide lactone precursor of actinomycin by a nonribosomal mechanism.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 9573200; See PMID 9667890
An12g07240	Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis
An12g07250	Similarity: protein is more than twice as long as protein from T. maritima and shows similarity twice to full length of T. maritima protein, stronger at N-terminus and weaker at C-terminus.; Title: similarity to hypothetical conserved protein - Thermotoga maritima
An12g07260	Title: strong similarity to hypothetical protein SC4B10.22 - Streptomyces coelicolor
An12g07270	Title: similarity to hypothetical protein encoded by An14g02930 - Aspergillus niger
An12g07280	Catalytic activity: an aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2).; Function: a double bond conjugated with a primary alcohol is necessary for substrate recognition by P. eryngii aao, and that activity is increased by the presence of additional conjugated double bonds and electron donor groups.; Function: aao from P. eryngii is an extracellular enzyme and constitutes a source for H2O2 required in lignin biodegradation.; Function: aao from P. eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; extracellular/secretion proteins; See PMID 10377251; See PMID 1425667
An12g07320	Function: AWI 31 from A. thaliana is specifically induced by wounding.; Title: strong similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278
An12g07330	Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Function: facB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans
An12g07340	Title: similarity to hypothetical protein EAA61153.1 - Aspergillus nidulans
An12g07350	Remark: shows unspecific similarity to serine rich proteins.
An12g07360	Function: S. cerevisiae Hub1 is an ubiquitin like protein that becomes covalently attached to target proteins and likely regulates activity of target proteins.; Remark: information regarding S. cerevisiae Hub1 has not been published and is available at http://www. biochem. mpg. de/jentsch/Jentsch. html.; Remark: the systematic name for S. cerevisiae HUB1 is YNR032c-a.; Title: strong similarity to ubiquitin like modifier Hub1 - Saccharomyces cerevisiae
An12g07370	Remark: part of the predicted A. niger protein is identical to an A. niger EST, an_3257.; Similarity: a DNA-binding motif within the predicted A. niger protein is only detected against the Structural Classification of Proteins database, not against other protein motif databases.; Similarity: the predicted A. niger protein shows similarity to several DNA-binding proteins.; Title: similarity to hypothetical protein CAE76230.1 - Neurospora crassa
An12g07380	Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Similarity: the predicted A. niger protein shows simiilarity to several monooxygenases involved in polyketide or sterois metabolism.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719
An12g07390	Catalytic activity: phenol hydroxylases transform phenol + NADPH2 + O2 to catechol + NADP + H2O.; Complex: T. cutaneum phenol hydroxylase is a dimeric flavoenzyme.; Function: T. cutaneum phenol hydroxylase forms the first step in phenol metabolism by o-hydroxylysing phenol.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 1429434; See PMID 7851397
An12g07400	Function: S. cerevisiae TPO1 mediates H+-gradient dependent vacuolar transport of polyamines, like spermine (TC 2. A. 1. 2).; Function: S. cerevisiae TPO1 shows hight structural similarity to E. coli PotE which mediates membrane potential dependent uptake of putrescine, while excretion involves an exchange reaction between putrescine and ornithine.; Remark: the systematic name for S. cerevisiae TOP1 is YLL028w.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11470516
An12g07420	Title: weak similarity to hypothetical protein encoded by An01g10470 - Aspergillus niger
An12g07430	Similarity: the central region of the predicted A. niger protein contains a glyoxalase II hydrolase motif.; Title: similarity to homeostasis assocoiated protein sequence SEQ ID NO:380 from patent WO200100842-A2 -Corynebacterium glutamicum
An12g07450	Function: S. cerevisiae Rgt2p is a glucose sensor in the membrane which generates the intracellular signal inhibiting the transcriptional repressor Rgt1.; Function: inhibition of Rgt1 by S. cerevisiae Rgt2p induces expression of HXT glucose transporters.; Remark: the systematic name for S. cerevisiae RGT2 is YDL138w.; Title: strong similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9564039; See PMID 10477308
An12g07470	Function: N. ellipsosporum CV-N has anti-HIV activity.; Remark: blastp shows significant similarity (45% positives) between predicted A. niger protein and N. ellipsosporum CV-N but due to shortness of both peptides the calculated probability is low (p=0,018).; Title: weak similarity to cyanovirin-N CV-N - Nostoc ellipsosporum; See PMID 9299483
An12g07480	Title: questionable ORF
An12g07490	Function: rhlG encodes an NADPH-dependent beta-ketoacyl reductase which is specifically involved in the synthetic pathway for the fatty acid moiety of rhamnolipids.; Title: similarity to beta-ketoacyl reductase rhlG -Pseudomonas aeruginosa; See PMID 9721281
An12g07500	Catalytic activity: {(1,4)-alpha-D-galacturonide}(N) + H(2)O = {(1,4)-alpha-D- galacturonide}(N-1) + D-galacturonate.; Function: pgaX is an exopolygalacturonase [poly(1,4-alpha-D-galacturonide)galacturonohydrolase] that cleaves monomer units from the non-reducing end of pectate and other galacturonans.; Induction: expression of the pgaX gene is inducible with galacturonic acid.; Repression: expression of the pgaX gene is subject to catabolite repression.; Title: strong similarity to exopolygalacturonase pgaX - Aspergillus tubingensis; extracellular/secretion proteins; See PMID 10467119; See PMID 8856078
An12g07510	Title: similarity to secreted protein #70 from patent WO9925825-A2 - Homo sapiens
An12g07520	Remark: the 10. 5 kD subunit of the respiratory chain complex I is one of the smallest chains.; Title: strong similarity to 10.5 kD subunit of NADH:ubiquinone reductase CI-B8 - Bos taurus; localisation:mitochondrion; See PMID 1518044
An12g07530	Remark: sequencing error at position 15524, 1 bp too much.; Title: strong similarity to hypothetical protein B2J23.80 - Neurospora crassa [putative frameshift]; putative frameshift
An12g07540	Complex: it appears that Chs4p is involved in chitin synthase 3 activity by combining with Chs3p to interact synergistically in chitin biosynthesis.; Function: CHS4 is involved in chitin biosynthesis.; Phenotype: CSH4 null mutants have a chitin content of 10% of that of the parental strain.; Title: similarity to chitin synthase regulatory factor CHS4 - Candida albicans; See PMID 10439400
An12g07550	Title: weak similarity to regulator protein Cbp4 -Saccharomyces cerevisiae
An12g07570	Function: SNC2 mediates the targeting and transport of secretory proteins.; Similarity: SNC2 is a homolog of the yeast SNC1 gene and of the vertebrate synaptic vesicle-associated membrane proteins synaptobrevin and VAMP.; Title: strong similarity to synaptobrevin Snc2 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8374953
An12g07580	Remark: N-Acetylglutamate kinase (AGK) and N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) function as two separate mitochondrial enzymes, but are encoded by the single nuclear gene arg-6 in Neurospora crassa.; Title: strong similarity to acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase precursor arg-6 - Neurospora crassa; localisation:mitochondrion; See PMID 7907589
An12g07590	Function: cohesin Rec8 is required for reductional chromosome segregation at meiosis.; Phenotype: when the rec8 gene is deleted, sister chromatids separate at meiosis I, resulting in equational rather than reductional chromosome segregation.; Remark: N-terminally truncated due to contig border.; Remark: the reductional segregation of the first stage of meiotic cell division (meiosis I) requires that sister chromatids remain associated through their centromeres and move together to the same pole.; Title: similarity to meiotic cohesin rec8p -Schizosaccharomyces pombe [truncated ORF]; See PMID 1339382; See PMID 10440376
An12g07600	Title: weak similarity to protein SEQ ID NO: 2310 from patent US6562958-B1 - Acinetobacter baumannii
An12g07620	Title: strong similarity to hypothetical protein encoded by An15g05550 - Aspergillus niger
An12g07630	Catalytic activity: 2-methylisocitrate is converted to succinate and pyruvate by ICL2.; Induction: in glucose-limited cultures, growth with threonine as a nitrogen source results in a threefold induction of ICL2 mRNA levels and of 2-methylisocitrate lyase activity in cell extracts relative to cultures grown with ammonia as the nitrogen source.; Localization: 2-methylisocitrate lyase is located in the mitochondrial matrix.; Pathway: ICL2 catalyzes a step in the methylcitrate cycle of threonine catabolism.; Remark: the catalyzed reaction is similar to that catalyzed by isocitrate lyase.; Repression: transcription of ICL2 is subject to glucose catabolite repression.; Title: strong similarity to 2-methylisocitrate lyase Icl2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11092862
An12g07660	Catalytic activity: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.; Function: asnB is involved in asparagine biosynthesis in vegetative cells.; Induction: in rich sporulation medium asnB is expressed only during exponential growth but is constitutively expressed in minimal medium.; Phenotype: deletion of asnB leads to a slow-growth phenotype, even in the presence of asparagine.; Remark: Bacillus subtilis has three asparagine synthetase genes, asnB, asnH, and asnO.; Title: strong similarity to asparagine synthase asnB - Bacillus subtilis; See PMID 10498721
An12g07670	Title: strong similarity to hypothetical lactam utilization protein lamB - Aspergillus nidulans
An12g07690	Function: LYS14 activates the transcription of at least four genes involved in lysine biosynthesis.; Induction: transcriptional activation by LYS14 is dependent on the inducer alpha-aminoadipate semialdehyde,an intermediate of the pathway.; Remark: LYS14 has a cysteine-rich DNA-binding motif of the Zn(II)2Cys6 type in its N-terminal portion.; Repression: LYS14 mediates repression by lysine.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; See PMID 7935367
An12g07700	Similarity: the predicted ORF shows strong similarity to Aspergillus oryzae EST SEQ ID NO:6167 of patent n. WO200056762-A2.; Title: weak similarity to hypothetical protein b2460 - Escherichia coli
An12g07710	Function: DBF20 of S. cerevisiae is involved in termination of M-phase.; Induction: the transcription of DBF20 of S. cerevisiae is not cell-cycle regulated.; Similarity: the predicted ORF and DBF20 of S. cerevisiae show strong similarity to Dbf2 and to other Ser/Thr protein kinases.; Title: strong similarity to protein kinase Dbf20 -Saccharomyces cerevisiae; See PMID 9613578; See PMID 1916278; See PMID 8131744; See PMID 8307336; See PMID 9528782
An12g07715	Title: weak similarity to hypothetical protein SPAC25B8.18 - Schizosaccharomyces pombe
An12g07720	Catalytic activity: NADH + 2 Fe3+ = NAD+ + 2 Fe2+.; Function: iron uptake in S. cerevisiae involves at least two steps: reduction of ferric to ferrous ions extracellularly and transport of the reduced ions through the plasma membrane; FRE2, together with FRE1, is shown to account for the total membrane-associated ferric reductase activity of the cell.; Induction: FRE2 of S. cerevisiae is induced by iron-deprivation like FRE1, but temporal regulation during growth differs from that of FRE1.; Title: strong similarity to ferric/cupric reductase Fre2 - Saccharomyces cerevisiae; plasma membrane; See PMID 9546033; See PMID 9726978; See PMID 8164662; See PMID 8940093; See PMID 9153234
An12g07730	Similarity: the aligment is over the first half of both proteins.; Title: weak similarity to copper transport protein COPT1 - Arabidopsis thaliana; See PMID 7499355
An12g07740	Remark: mithramycin is a glycosylated aromatic polyketide produced by Streptomyces argillaceus, and is used as an antitumor drug.; Remark: the mtmU gene from Streptomyces argillaceus codes for a 4-ketoreductase involved in D-oliose biosynthesis, and its inactivation resulted in the accumulation of premithramycinone and premithramycin A, the first glycosylated intermediate which contains a D-olivose unit.; Title: similarity to D-oliose 4-ketoreductase mtmU -Streptomyces argillaceus; See PMID 11254130
An12g07750	Title: similarity to hypothetical serine repeat antigen BAA78500.1 - Plasmodium falciparum
An12g07760	Catalytic activity: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.; Pathway: phospholipid degradation.; Remark: strong similarity to human lysophospholipase extended NHLP patent WO9849319-A1.; Title: strong similarity to lysophospholipase extended NHLP from patent WO9849319-A1 - Homo sapiens
An12g07770	Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 6347 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:6347 from patent EP1033405-A2 - Arabidopsis thaliana
An12g07780	Remark: strong similarity to human sequence 79 from patent EP1067182-A/79.; Similarity: to dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: strong similarity to sequence 79 from patent EP1067182-A - Homo sapiens
An12g07790	Remark: BTF3 is a protein initially identified in HeLa cells that may be involved in the initiation of transcription. Although its specific role in transcription is unclear, BTF3 can form a stable complex with RNA polymerase II.; Remark: the ORF encoded protein shows also strong similarity to Aspergillus oryzae EST SEQ ID NO:4910.; Title: strong similarity to transcription factor btf3p - Schizosaccharomyces pombe; See PMID 8809106
An12g07800	Remark: most of the homologues are only the half of the length.; Title: strong similarity to hypothetical coronin-like protein SPAC11E3.05 - Schizosaccharomyces pombe
An12g07810	Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Pathway: second step in ubiquitin conjugation.; Remark: strong similarity to human ubiquitin-conjugating enzyme 2 UCE2 patent CN1268564-A.; Remark: the human gene product expressed in Escherichia coli exhibited the ability to form a thiol ester linkage with ubiquitin in a ubiquitin-activating enzyme E1-dependent manner.; Similarity: to the Drosophila's bendless gene product.; Title: strong similarity to ubiquitin-conjugating enzyme 2 UCE2 from patent CN1268564-A - Homo sapiens; See PMID 8902611
An12g07830	Remark: ribosomal protein L32 regulates the splicing of the transcript of its own gene, RPL32.; Remark: strong similarity to EST an_2400 and an_3018 Aspergillus niger.; Similarity: belongs to the ribosomal protein L24E family.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L30 - Kluyveromyces lactis; cytoplasm; See PMID 2040015
An12g07840	Catalytic activity: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.; Pathway: glutamate metabolism; aminosugars metabolism.; Remark: GNA1 (also known as PAT1) is required for multiple steps in the cell cycle, such as exit from G0,progression of DNA synthesis, and mitosis.; Remark: the recombinant yeast protein for YFL017C (GNA1) displayed phosphoglucosamine acetyltransferase activities in vitro and utilized glucosamine 6-phosphate as the substrate. GNA1, a member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, participates in UDP-GlcNAc biosynthesis by catalyzing the formation of GlcNAc6P from AcCoA and GlcN6P.; Similarity: belongs to the family of acetyltransferases.; Title: strong similarity to glucosamine-phosphate N-acetyltransferase Gna1 - Saccharomyces cerevisiae; See PMID 9077451; See PMID 9867860; See PMID 11278591
An12g07850	Catalytic activity: (S)-malate = fumarate + H2O.; Pathway: citrate cycle (TCA cycle); reductive carboxylate cycle (CO2 fixation).; Remark: a splice site was detected upstream of the START codon.; Remark: the level of fumR RNA from R. oryzae increased in cells producing FA under stress conditions (high carbon and low nitrogen levels in the medium),suggesting that transcriptional regulation of fumR might be involved in the overproduction and accumulation of FA by Ro cells under stress conditions.; Similarity: belongs to the fumarate hydratase.; Title: strong similarity to fumarate hydratase fumR - Rhizopus oryzae; See PMID 7557464
An12g07860	Remark: also strong similarity to Sulfolobus solfataricus esterase P1-8LC patent WO9730160-A1.; Remark: strong similarity to EST SEQ ID NO:4009 from Aspergillus niger.; Title: strong similarity to esterase P1-8LC from patent WO9730160-A1 - Sulfolobus solfataricus
An12g07870	Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Remark: alternative names are YLR027c, ASP5.; Remark: the gene AAT2 codes for the cytosolic and peroxisomal AAT activities. Disruption of the AAT2 gene did not affect growth on oleate. Furthermore beta-oxidation of palmitate was normal. AAT2 is not essential for the peroxisomal NAD(H) redox shuttle.; Similarity: belongs to the class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to cytosolic aspartate transaminase Aat2 - Saccharomyces cerevisiae; See PMID 9288922; See PMID 9655342
An12g07880	Remark: CHS5 of S. cerevisiae is involved in chitin synthase III activity, also required for homozygosis in the first stages of mating.; Remark: Chs5p is required for the polarization of Chs3p. in wild-type cells, Chs3p is polarized as a diffuse ring at the incipient bud site and at the neck between the mother and bud in small-budded cells; it is not found at the neck in large-budded cells containing a single nucleus.; Remark: alternative names are CAL3, YLR330W.; Remark: the homologues proteins are C-terminally longer.; Title: strong similarity to chitin synthesis protein Chs5 - Saccharomyces cerevisiae; See PMID 9008706; See PMID 9111317
An12g07900	Remark: shows strong similarity to EST an_3273 Aspergillus niger.; Remark: the small human eukaryotic initiation factor (eIF)-4C is implicated in the initiation pathway, where it enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(i) to 40 S ribosomal subunits.; Similarity: belongs to the eif-1a family.; Title: strong similarity to protein synthesis factor eIF-4C - Homo sapiens; See PMID 8106356
An12g07910	Remark: mus-38 participates in a different NER (nucleotide excision repair) pathway from that involving the mus-18 gene.; Similarity: to the yeast RAD1 protein.; Title: strong similarity to component of the nucleotide excision repairosome MUS38 - Neurospora crassa; See PMID 9560435
An12g07920	Remark: the ORF is short in length (70 amino acids).
An12g07930	Remark: C-terminal truncated ORF due to end of contig.; Remark: yeast Las17 protein is homologous to the Wiskott-Aldrich Syndrome protein, which is implicated in severe immunodeficiency. Las17p/Bee1p has been shown to be important for actin patch assembly and actin polymerization.; Title: strong similarity to proline-rich protein Las17 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9742397; See PMID 10512884; See PMID 10648568; See PMID 8105860
An12g07940	Title: similarity to hypothetical protein Y48E1B.1 -Caenorhabditis elegans [truncated ORF]
An12g07950	Function: MRS2 of S. cerevisiae is essential for the excision of group II introns from mitochondrial transcripts in vivo.; Remark: MRS2 of S. cerevisiae is a nuclear encoded protein involved in mitochondrial biogenesis.; Title: strong similarity to mitochondrial RNA splicing protein Mrs2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1551905
An12g07960	Title: strong similarity to hypothetical protein YPL030w - Saccharomyces cerevisiae
An12g07990	Similarity: shows unspecific matches to Glu-rich domains of various proteins from diverse species.
An12g08000	Function: Pfam and COG motives suggest a putative ketopantoate reductase.; Title: strong similarity to hypothetical protein SPCC1902.02 - Schizosaccharomyces pombe
An12g08010	Title: weak similarity to homeobox protein HOXC13 -Homo sapiens
An12g08020	Pathway: phosphoglycerate mutase catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate (the substrate of enolase) in glycolysis and the reverse reaction in gluconeogenesis.; Title: strong similarity to hypothetical phosphoglycerate mutase YKR043c - Saccharomyces cerevisiae
An12g08030	Function: SUB2 of S. cerevisiae is essential for prespliceosome formation.; Remark: the systematic gene name of SUB2 of S. cerevisiae is YDL084w.; Similarity: belongs to the DEAD-box family of ATP-dependent RNA helicases.; Similarity: belongs to the superfamily II of DNA and RNA helicases.; Title: strong similarity to NADH oxidoreductase complex I subunit Sub2 - Saccharomyces cerevisiae; nucleus; See PMID 11156604
An12g08040	Complex: ribonuclease P of H. sapiens is a ribonucleoprotein complex with several protein subunits.; Function: ribonuclease P of H. sapiens is involved in tRNA processing in the nucleus.; Title: similarity to hypothetical ribonuclease P subunit Rpp21 - Homo sapiens
An12g08050	Title: strong similarity to EST an_2641 -Aspergillus niger
An12g08060	Similarity: shows similarity to 5'-ESTs of the A. nidulans cDNA clones r2e05a1 and m7g05a1.; Title: strong similarity to hypothetical protein CAE76529.1 - Neurospora crassa
An12g08090	Title: weak similarity to actin filament-binding protein b-nexilin - Rattus norvegicus; See PMID 9832551
An12g08100	Function: nimA of A. nidulans is involved in cell cycle control and chromatin condensation.; Function: the kinase activity of nimA of A. nidulans has not been demonstrated experimentally.; Phenotype: overexpression of nimA in A. nidulans causes mitotic induction.; Similarity: also shows similarity to other protein kinases.; Similarity: an N-terminal fragment of nimA of A. nidulans is subject of the protein patent WO9966051-A2 (PATENTPROT:AAY59147).; Title: strong similarity to serine/threonine protein kinase nimA - Aspergillus nidulans; See PMID 3359487
An12g08110	Similarity: contains ankyrin-repeat and BPOZ-domain-like regions which are thought to mediate protein-protein interactions.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAB64399.; Title: strong similarity to intracellular signalling protein INTRA31 from patent WO200077040-A2 - Homo sapiens
An12g08130	Title: questionable ORF
An12g08160	Title: questionable ORF
An12g08170	Remark: shep-GRP of C. bursa-pastoris is a precursor polypeptide for two glycine/histidine-rich peptides,shepherins I (28 aa) and II (38 aa).; Similarity: the homology region covers the complete shepherin I sequence.; Title: weak similarity to antimicrobial peptide precursor shep-GRP - Capsella bursapastoris; See PMID 11117262
An12g08210	Similarity: the C-terminus shows similarity to a conserved domain of transcription factors of the Brn-3b family.; Title: questionable ORF
An12g08230	Remark: the initiation of conidiophore development in the filamentous fungus Aspergillus nidulans is a complex process requiring the activities of several genes including fluG, flbA, flbB, flbC, flbD, and flbE. Recessive mutations in any one of these genes result in greatly reduced expression of the brlA developmental regulatory gene and a colony morphology described as fluffy. These fluffy mutants have somewhat diverse phenotypes but generally grow as undifferentiated masses of vegetative hyphae to form large cotton-like colonies.; Title: strong similarity to zinc-finger protein flbC - Aspergillus nidulans; See PMID 9339347; See PMID 8978035
An12g08240	Remark: similarity to HTRM (human transcriptional regulatory molecule) clone 2674047 patent WO9957144-A2.; Title: similarity to human transcriptional regulatory protein from patent WO9957144-A2 - Homo sapiens
An12g08260	Remark: all other found homologues are shorter in lenght.; Remark: similarity to amino acid sequence of a human hydrolytic enzyme HYENZ8 patent WO200116334-A.; Title: similarity to C-terminus of a human hydrolytic enzyme HYENZ8 from patent WO200116334-A2 - Homo sapiens
An12g08270	Catalytic activity: (S)-lactate + O2 = acetate + CO2 + H2O.; Pathway: pyruvate metabolism.; Remark: L-Lactate 2-monooxygenase catalyzes the oxidation of L-lactate to acetate and carbon dioxide.; Similarity: belongs to the FMN-dependent alpha-hydroxy acid dehydrogenases family.; Title: strong similarity to L-lactate 2-monooxygenase LA2M - Mycobacterium smegmati; See PMID 2324094; See PMID 3571231
An12g08280	Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides; Function: the exo-inulinase inu1 from A. niger hydrolyses inulin and levan.; Gene-ID: inu1; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: Sucrose-inducible secretory sucrose:sucrose 1-fructosyltransferase (1-SST) from Aspergillus foetidus is extensively glycosylated, and the active form is probably represented by a dimer of identical subunits with an apparent molecular mass of 180 kDa. Expression of the cloned gene in an invertase-deficient mutant of S. cerevisiae resulted in 1-kestose production, with 6-kestose and neokestose being side products of the reaction.; Remark: identical to DNA and protein sequence of sucrose:sucrose 1-fructosyltransferase from Aspergillus foetidus.; Similarity: belongs to family 32 of glycosyl hydrolases.; See PMID 9495772
An12g08300	Title: similarity to hypothetical protein encoded by An04g09580 - Aspergillus niger
An12g08320	Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An12g08340	Title: strong similarity to hypothetical protein B2J23.50 - Neurospora crassa
An12g08350	Phenotype: disruption of TRI12 of F. sporotrichioides results in both reduced growth on complex media and reduced levels of trichothecene production.; Remark: growth of TRI12 mutants on trichothecene-containing media is inhibited, suggesting that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to trichothecene efflux pump TRI12 - Fusarium sporotrichioides; See PMID 10485289
An12g08360	Title: similarity to hypothetical protein YER182w -Saccharomyces cerevisiae
An12g08370	Catalytic activity: UBP6 of S. cerevisiae preferentially hydrolyzes ubiquitin-carboxy-terminal alpha-NH-protein extensions.; Function: UBP6 of S. cerevisiae is probably involved in the deubiquitination of polyubiquitinated proteins targeted for proteasomal degradation.; Function: UBP6 of S. cerevisiae probably plays an important role in the generation of free ubiquitin and ribosomal proteins from ubiquitin-ribosomal protein fusions.; Remark: the systematic gene name of UBP6 in S. cerevisiae is YFR010w.; Similarity: UBP6 of S. cerevisiae belongs to the ubiquitin carboxyl-terminal hydrolases family 2 (also known as peptidase family C19).; Similarity: also shows strong similarity to queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase,guanine insertion enzyme; EC 2. 4. 2. 29) of various species.; Similarity: contains a ubiquitin-like domain in the N-terminal part.; Similarity: the 3'-part of the ORF is nearly identical to a 5'-EST of the A. niger cDNA clone 3200 (EMBLEST:BE758940).; Title: strong similarity to ubiquitin specific protease Ubp6 - Saccharomyces cerevisiae; See PMID 9344467; See PMID 10386876; See PMID 8982460
An12g08380	Complex: p20-Arc of H. sapiens forms part of the heteroheptameric Arp2/3 complex composed of Arp2, Arp3,p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc.; Function: the Arp2/3 complex of H. sapiens promotes actin polymerization in lamellipodia of motile cells and participates in lamellipodial protrusion.; Localization: the Arp2/3 complex of H. sapiens is localized to the actin-rich lamellipodia at the leading edge of motile cells.; Similarity: the 5'-part of the ORF shows strong similarity to a 5'-EST of the A. niger cDNA clone 3082 (EMBLEST:BE758834).; Title: strong similarity to Arp2/3 complex subunit p20-Arc - Homo sapiens; cytoskeleton; See PMID 9230079
An12g08390	Complex: hnRNP F in H. sapiens forms part of hnRNP complexes associated with pre-mRNAs containing guanosine-rich sequences.; Function: hnRNP F in H. sapiens is involved in the processing of mRNAs containing guanosine-rich sequences.; Localization: hnRNP F in H. sapiens is concentrated in discrete regions of the nucleoplasm.; Title: similarity to heterogeneous nuclear ribonucleoprotein hnRNP F - Homo sapiens; See PMID 7512260
An12g08400	Similarity: the 3'-part of the ORF shows strong similarity to a 3'-EST of the A. niger cDNA clone 1672 (EMBLEST:BE760426).; Title: strong similarity to hypothetical protein YGL050w - Saccharomyces cerevisiae
An12g08410	Similarity: also shares some homology with the C-terminal part of the Alpha-ketoglutarate dehydrogenase E1 subunit of patent GENESEQPROT:Y32087.; Title: weak similarity to hypothetical transcription factor MBK20.16 - Arabidopsis thaliana
An12g08430	Title: weak similarity to hypothetical protein PA2750 - Pseudomonas aeruginosa
An12g08440	Title: weak similarity to hypothetical protein gom -Drosophila melanogaster
An12g08460	Function: the products of patent GENESEQPROT:Y07772 are useful for diagnosis, prevention, treatment or amelioration of medical conditions by means of e. g. protein or gene therapy.; Remark: protein patent GENESEQPROT:Y07772 describes human genes and their protein products.; Title: weak similarity to human secreted protein 29 from patent WO9909155-A1 - Homo sapiens
An12g08500	Title: questionable ORF
An12g08510	Similarity: contains a putative fungal Zn(2)-Cys(6)-type DNA-binding domain.; Similarity: shows unspecific matches to diverse proline-rich proteins of various species.; Title: similarity to hypothetical protein encoded by An11g02690 - Aspergillus niger
An12g08530	Function: Hsl1p in S. cerevisiae is involved in Swe1p-targeting for degradation during the G2/M transition.; Function: Hsl1p in S. cerevisiae is part of the septin-dependent morphogenesis checkpoint for the G2/M-transition.; Function: Hsl1p in S. cerevisiae is required for Swe1p localization to the bud neck septin ring.; Function: Hsl1p in S. cerevisiae requires septins and Hsl7p binding for proper targeting of Swe1p.; Localization: Hsl1p in S. cerevisiae colocalizes with Hsl7p and Swe1p to the daughter side of the mother bud neck.; Pathway: Hsl1p in S. cerevisiae down-regulates Swe1p which in turn is an inhibitor of Cdc28.; Phenotype: disruption of HSL1 in S. cerevisiae is synthetically lethal in combination with a deletion of the amino terminus of histone H3.; Phenotype: disruption of HSL1 in S. cerevisiae leads to a Swe1p-mediated G2 delay.; Remark: HSL1 in S. cerevisiae is also called NIK1.; Remark: the ORF is N-terminally truncated due to end of contig.; Remark: the systematic name of HSL1 in S. cerevisiae is YKL101w.; Title: similarity to Swe1 regulating protein kinase Hsl1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10805747; See PMID 8647431
An12g08540	Function: together with Hsl7, the Hsl1 protein kinase induces the degradation of the Swe1 protein kinase. Hsl1p and Hsl7p interact directly with Swe1 to promote its recognition by the ubiquitination complex. Hsl1 is a negative regulator for Swe1. Swe1 phosphorylates Cdc2-type cyclin-dependent kinases (Cdc28p in S. cerevisiae). Morphogenesis influences cell-cycle and nuclear division. A cell cycle delay induced by the morphogenesis checkpoint requires Swe1p.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for S. cerevisiae Hsl1: YKL101W, Nik1.; Title: strong similarity to Swe1 regulating protein kinase Hsl1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10490630; See PMID 10679396; See PMID 11230131
An12g08550	Title: strong similarity to hypothetical protein AAC25763.1 - Streptomyces lividans
An12g08560	Title: strong similarity to proteinase SlpE -Streptomyces lividans; See PMID 7592364
An12g08570	Function: Peroxidases of the peroxiredoxin (Prx) family catalyze the reduction of H(2)O(2) and lipid peroxides.; Title: similarity to type 2 peroxiredoxin PrxII -Brassica napus; peroxisome; See PMID 10329461
An12g08580	Catalytic activity: the yeast RNAseP shows endonucleolytic cleavage activity for RNA, removing 5'-extra-nucleotide from a tRNA precursor.; Complex: the yeast RNAseP consists of a RNA moiety and at least 8 protein subunits: Pop1, Pop3, Pop4, Pop5,Pop6, Pop7, Pop8 and Ppp1.; Function: the Pop1 gene product from S. cerevisiae is required for processing of 5. 8s rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.; Title: strong similarity to ribonuclease P chain Pop1 - Saccharomyces cerevisiae; nucleus; See PMID 7926742
An12g08590	Title: similarity to hypothetical protein YFR011c -Saccharomyces cerevisiae
An12g08600	Remark: this ORF overlaps with an EST that belongs to the following A. niger glkA gene.; Title: questionable ORF
An12g08610	Catalytic activity: ATP + D-glucose <=> ADP + D-glucose 6-phosphate.; Function: the glucokinase GlkA from A. niger has great affinity for glucose. Mannose, 2-deoxyglucose and glucosamine can serve as substrates. Its activity is relatively constant between pH 7. 5 and pH 9. 0. below pH 7. 5, the activity decreases with pH.; Gene-ID: GlkA; Pathway: Glycolysis.; cytoplasm; See PMID 8856049
An12g08620	Remark: Botryotinia fuckeliana=Botrytis cinerea.; Similarity: the Bcmfs1 protein from Botryotinia fuckeliana belongs to the major facilitator family of transporters.; Title: strong similarity to MFS drug transporter Bcmfs1 - Botryotinia fuckeliana; plasma membrane; See PMID 11374155
An12g08630	Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotricodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An12g08640	Function: mammalian ASC-1 is involved in transcriptional activation.; Remark: the mammalian ASC-1 protein is a coactivator molecule of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1.; Title: similarity to transcription coactivator ASC-1 - Mus musculus; nucleus; See PMID 10454579
An12g08650	Remark: the E. nidulans ptaC mRNA can become alternatively spliced.; Title: strong similarity to hypothetical transcriptional activator ptaC - Aspergillus nidulans
An12g08660	Title: weak similarity to protein fragment SEQ ID NO: 16694 from patent EP1033405-A2 - Arabidopsis thaliana
An12g08670	Complex: S. cerevisiae Rrp42 is an 'exosome' 3->5 exoribonuclease complex component with Rrp4, Rrp41, Rrp43 and Dis3 (Rrp44); Function: this S. cerevisiae 'exosome' 3->5 exoribonuclease complex is required for the 3' processing of the 7s pre-rRNA to the mature 5. 8s rRNA.; Remark: alternate name for S. cerevisiae Rrp42: YDL111c.; Similarity: S. cerevisiae Rrp42p is related to RNase PH.; Title: similarity to 3-5 exoribonuclease involved in rRNA processing Rrp42 - Saccharomyces cerevisiae; nucleus; See PMID 9390555; See PMID 10465791
An12g08680	Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0).; Similarity: cyp-4 from C. elegans belongs to the cyclophilin-type peptidylprolyl isomerasease family.; Title: strong similarity to cyclophilin isoform 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762
An12g08690	Function: S. cerevisiae Mrs6 (geranylgeranyl transferase component A) binds to unprenylated Rab (G-protein), presents it to the catalytic component B (Bet2), and remains bound to it after the geranylgeranyl transfer reaction. Mrs6 (component A) may be regenerated by transferring its prenylated Rab to a protein acceptor.; Remark: alternate names for S. cerevisiae Mrs6: YOR370C, MSI4.; Title: strong similarity to Rab geranylgeranyl transferase component A Mrs6 - Saccharomyces cerevisiae; See PMID 8183917; See PMID 7882424; See PMID 8132658
An12g08720	Title: similarity to hypothetical protein AAG27909.1 - Arabidopsis thaliana
An12g08730	Function: the S. cerevisiae Mcm1 protein is a DNA-binding transcription factor involved in transcriptional regulation of several different target genes. For example it interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes.; Remark: alternate names for S. cerevisiae Mcm1: Fun80, YMR043W.; Title: similarity to MADS-box domain transcription factor Mcm1 - Saccharomyces cerevisiae; nucleus; See PMID 9490409; See PMID 3066908
An12g08750	Title: similarity to hypothetical protein At2g21120 - Arabidopsis thaliana
An12g08760	Complex: N. crassa Vma-4 belongs to the v-ATPase an heteromultimeric enzyme composed of a peripheral catalytic v1 complex (components A to H) attached to an integral membrane v0 proton pore complex (components: A, C, C', C'' and D).; Function: N. crassa Vma-4 is a subunit of the peripheral v1 complex of vacuolar ATPase (v-ATPase). The V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to vacuolar ATPase subunit E Vma-4 - Neurospora crassa; vacuole; See PMID 10340846; See PMID 7619848
An12g08790	Function: the human FIC1 protein encodes putative integral membrane P-type ATPase and potential aminophospholipid translocase (or flippase). It may play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. It may have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both.; Remark: defects in FIC1 also are the cause of benign recurrent intrahepatic cholestasis (bric or summerskill syndrome), an autosomal recessive disorder, characterized by intermittent episodes of cholestasis without extrahepatic bile duct obstruction, with initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months.; Remark: defects in FIC1 are the cause of progressive familial intrahepatic cholestasis type 1 (pfic1 or byler disease), an autosomal recessive disorder, characterized by early infancy cholestasis, that may be initially episodic but progresses to malnutrition, growth retardation and end-stage liver disease before adulthood.; Remark: defects in fic1 could be associated with recurrent intrahepatic cholestasis of pregnancy (icp or ricp pregnancy-related cholestasis), characterized by generalized itching, with or without jaundice, absence of biliary colic, absence of jaundice or pruritus between pregnancies, and absence of chronic liver disease. appears during pregnancy (primarily in the third trimester), and disappears shortly postpartum. may be a female-limited autosomal dominant inheritance.; Title: strong similarity to P-type ATPase FIC1 -Homo sapiens; See PMID 9500542
An12g08800	Function: S. cerevisiae Sen1 is required for endonucleolytic cleavage of introns from all families of precursor tRNAs. Sen1 is also involved in processing of rRNAs and small nuclear and nucleolar RNAs.; Remark: alternate names for S. cerevisiae Sen1: YLR430w, Cik3, Nrd2.; Similarity: S. cerevisiae Sen1 belongs to the Dna2/Nam7 helicase family.; Title: strong similarity to ATP dependent RNA helicase Sen1 - Saccharomyces cerevisiae; nucleus; See PMID 9365256; See PMID 9819377; See PMID 1569945
An12g08820	Remark: C-terminally truncated ORF due to the end of contig.; Title: weak similarity to for serine/threonine protein kinase NPKCSD - Suberites domuncula [truncated ORF]
An12g08830	Title: weak similarity to outer arm dynein light chain LC7 - Chlamydomonas reinhardtii; See PMID 10402468
An12g08890	Title: similarity to hypothetical protein EAA72664.1 - Gibberella zeae
An12g08900	Remark: also similarity to Trypanosoma cruzi cyclin 4 (cyc4).; Title: similarity to hypothetical Pcl-like cyclin pas1p - Schizosaccharomyces pombe
An12g08930	Catalytic activity: an epoxide + H2O = a glycol.; Function: hyl1 of A. niger hydrolyses 4-nitrostyrene epoxide and other epoxides.; Pathway: tetrachloroethene degradation; Remark: also strong similarity to Aspergillus niger epoxide hydrolase protein sequence SEQ ID NO:2 patent WO200068394-A1.; Remark: epoxide hydrolases have important roles in the defense of cells against potentially harmful epoxides. Conversion of epoxides into less toxic and more easily excreted diols is a universally successful strategy.; Remark: the sequence variantion might be sequence errors or strain variation.; Title: strong similarity to epoxide hydrolase hyl1 -Aspergillus niger; See PMID 10548561; See PMID 10673439
An12g08940	Remark: strong similarity to E. coli bioS1 protein patent DE19806872-A1.; Similarity: to nifS proteins.; Title: strong similarity to biotin biosynthesis gene bioS1 from patent DE19806872-A1 - Escherichia coli
An12g08950	Remark: the allantoin permease component encoded by DAL4 in S. cerevisiae has similarity to the uracil permease component encoded by FUR4.; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; See PMID 1293888; See PMID 11409177
An12g08960	Function: major nitrogen regulatory protein. positively acting regulatory gene of nitrogen metabolite repression.; Gene-ID: areA; Mapping: areA from A. niger is mapped to chromosome III (LG III); see list from DSM, PUBMED 11589576.; Remark: northern analysis indicates the synthesis of multiple transcripts, the major species being approximately 2. 95 kb and 3. 1 kb. Maximal expression of areAnig is observed under conditions of nitrogen starvation and is mainly due to an increase in the level of the shorter transcript.; Remark: putative sequencing error at position 41647,generating a stop codon.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Similarity: to other fungal nitrogen regulatory proteins. To gata transcription factors in the zinc-finger region.; nucleus; putative sequencing error; See PMID 9540832; See PMID 11589576
An12g08970	Remark: the ORF encoded protein shows similarities to the upstream region of the areA gene from Aspergillus niger.
An12g09020	Remark: the similarity is restricted only to the N-terminus.; Title: similarity to hypothetical protein CAD79668.1 - Neurospora crassa
An12g09050	Title: questionable ORF
An12g09080	Title: similarity to EST an_3065 - Aspergillus niger
An12g09090	Title: similarity to hypothetical protein encoded by An08g08730 - Aspergillus niger
An12g09120	Title: strong similarity to hypothetical protein EAA47516.1 - Magnaporthe grisea
An12g09130	Remark: similarity to maize ZmGnsN3 glucanase of patent WO200073470-A2 found in TREMBL:AX053132_1.; Remark: the predicted ORF is approximately N-terminal 60 amino acids longer.; Title: similarity to glucanase ZmGnsN3 from patent WO200073470-A2 - Zea mays
An12g09140	Remark: alternative name is YGR065c.; Remark: expression of YGR065C S. cerevisiae under the control of the constitutive ADH1 promoter resulted in very high biotin transport rates across the plasma membrane that were no longer regulated by the biotin concentration in the growth medium.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to H+-biotin symporter Vht1 - Saccharomyces cerevisiae; See PMID 10373489
An12g09150	Remark: strong similarity to Corynebacterium glutamicum sequence 419 from Patent WO0100842-A/419.; Similarity: belongs to the nitrilotriacetate monooxygenases.; Title: strong similarity to sequence 419 from patent WO0100842-A - Corynebacterium glutamicum
An12g09170	Remark: N-terminal truncated ORF due to end of contig.
An12g09190	Remark: similarity to human nucleic acid-binding protein, NuABP-10 patent WO200044900-A2.; Remark: the predicted ORF represents an putative zinc-finger protein.; Title: similarity to nucleic acid-binding protein NuABP-10 from patent WO200044900-A2 - Homo sapiens
An12g09260	Title: strong similarity to hypothetical protein CAF06101.1 - Neurospora crassa
An12g09270	Function: Lac12 from K. lactis mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; See PMID 3053697
An12g09280	Title: similarity to hypothetical protein encoded by An01g02930 - Aspergillus niger
An12g09310	Function: Bacillus subtilis PNB carboxy-esterase (PNBCE) catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Remark: p-Nitrobenzyl esters serve as protecting groups on intermediates in the manufacture of clinically important oral beta-lactam antibiotics; de-esterification of the intermediates is required for synthesis of the final product.; Similarity: belongs to the carboxylesterases type B.; Title: similarity to para-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An12g09330	Remark: in yeast PAD (phenylacrylic acid decarboxylase) activity and CA (cinnamic acid) resistance,but not steady-state PAD1 mRNA levels, are influenced by mitochondrial genotype. PAD1 is a single-copy gene in the yeast genome and not essential for viability.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae; See PMID 8181743
An12g09340	Remark: strong similarity to S. cerevisiae ferulic acid decarboxylasepatent EP857789-A2.; Remark: the S. cerevisiae enzyme is able to transform ferulic acid and p-coumaric acid to 4-vinylguaiacol and 4-vinylphenol, respectively, by nonoxidative decarboxylation.; Title: strong similarity to ferulic acid decarboxylase FDC1 from patent EP857789-A2 - Saccharomyces cerevisiae
An12g09350	Title: similarity to hypothetical protein PaxU -Penicillium paxilli
An12g09370	Remark: alternativ name is YDR497c.; Remark: gene disruption and tetrad analysis showed that yeast cells contain two separate myoinositol transporters. The ITR1 product was the major transporter and the ITR2 product the minor one in cells grown in minimum medium containing glucose. Northern blot analysis showed that ITR1 mRNA was much more abundant than ITR2 mRNA.; Title: strong similarity to myo-inositol permease Itr1 - Saccharomyces cerevisiae; See PMID 2040626
An12g09440	Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa
An12g09450	Remark: a heterologous gene encoding a gene product which confers trichothecene resistance can be used to transform plant cells to make them resistant to fungal infection.; Remark: similarity to yeast sequence encoding trichothecene resistance polypeptide patent WO200060061-A2.; Title: similarity to trichothecene resistance polypeptide from patent WO200060061-A2 - Saccharomyces cerevisiae
An12g09460	Remark: similarity to A. terreus ORF13 Zinc finger II protein patent WO200037629-A2.; Remark: the homologue regulatory protein is a member of the Aspergillus terreus lovastatin biosynthesis gene cluster.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to ORF13 Zinc finger II protein from patent WO200037629-A2 - Aspergillus terreus
An12g09470	Remark: Cofilin and related proteins isolated from diverse organisms are low molecular weight proteins (15-20 kD) that possess several activities in vitro. All bind to monomeric actin and sever filaments, and some can stably associate with filaments.; Remark: Cofilin from S. cerevisiae binds to and severs actin filaments in vitro, and also enhances their depolymerization.; Remark: alternate name is YLL050c .; Title: similarity to cofilin Cof1 - Saccharomyces cerevisiae; See PMID 10231390; See PMID 8421056; See PMID 8440472
An12g09480	Function: M. sativa F3H is involved in the synthesis of flavonoids.; Title: similarity to naringenin 3-dioxygenase F3H -Medicago sativa; See PMID 8541503
An12g09490	Function: S. cerevisiae VHT1 is a plasma membrane H+-biotin symporter.; Remark: the systematic name for S. cerevisiae VHT1 is YGR065. C; Title: strong similarity to H+-biotin symporter Vht1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10373489
An12g09500	Function: human ankyrin-1 provides the primary linkage between the membrane skeleton and integral plasma membrane proteins.; Title: similarity to ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 10810176
An12g09510	Catalytic activity: Hg + NADP(+) + H(+) = Hg(2+) + NADPH.; Remark: Microbes can detoxify organo-mercurials and mercury salts through sequential action of two enzymes,organomercury lyase and mercuric ion reductase (MerA).; Remark: N-terminally truncated due to contig border.; Similarity: MerA from Bacillus sp. strain RC607 shows homology to FAD-dependent disulphide oxidoreductases and to dihydrolipoamide dehydrogenases.; Title: similarity to mercury(II) reductase merA -Bacillus sp. [truncated ORF]; See PMID 2067577; See PMID 2536669
An12g09520	Title: weak similarity to hypothetical protein encoded by An02g13400 - Aspergillus niger
An12g09540	Title: strong similarity to hypothetical yellow-related protein DR1790 - Deinococcus radiodurans
An12g09550	Title: weak similarity to hypothetical poly(A) binding protein II PABPII - Xenopus laevis
An12g09560	Function: AvnA is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.; Remark: Aflatoxins are synthesized by condensation of acetate units.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Similarity: The avnA gene encodes a cytochrome P-450-type monooxygenase that has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431
An12g09580	Function: nit-4 is a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa which is required for the expression of the structural genes for nitrate and nitrite reductase.; Remark: nit-4 possesses a single Zn(II)2Cys6 binuclear-type zinc finger, which may mediate DNA binding.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1840634
An12g09600	Function: TNA1 is the yeast high affinity nicotinic acid permease.; Induction: The transcript levels of TNA1 increase when extracellular nicotinic acid and thiamine,respectively, are absent.; Similarity: TNA1 belongs to the yeast Dal5p subfamily of the major facilitator family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An12g09610	Title: weak similarity to hypothetical extensin homolog HRGP2 - Glycine max
An12g09630	Remark: Alterations of the azole target enzyme and the overexpression of multidrug efflux transporter genes are the most frequent azole resistance mechanisms in Candida albicans.; Remark: possible sequencing error at position 59218,2 bp too much.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 11065353
An12g09640	Title: strong similarity to hypothetical GTP cyclohydrolase CAB65619.1 - Schizosaccharomyces pombe
An12g09650	Title: strong similarity to hypothetical uracil phosphoribosyltranferase SPAC1002.17 - Schizosaccharomyces pombe
An12g09660	Catalytic activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: salvage pathway of pyrimidine metabolism.; Title: strong similarity to uracil phosphoribosyltransferase upp - Bacillus caldolyticus; See PMID 9268683
An12g09670	Catalytic activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: Salvage pathway of pyrimidine metabolism.; Title: strong similarity to uracil phosphoribosyltransferase UPRT - Toxoplasma gondii; See PMID 9247925
An12g09680	Catalytic activity: 2-methyl-3-oxopropanoate + CoA + NAD(+) = propanoyl-CoA + CO(2) + NADH.; Title: strong similarity to methylmalonate-semialdehyde dehydrogenase precursor MMSDH -Bos taurus; See PMID 8514806
An12g09700	Complex: PRAP (PRL Receptor Associated Protein) is an ovarian-specific protein that associates with the short form of the prolactin receptor.; Function: PRAP may contribute to the luteotropic effects of PRL on the corpus luteum during pregnancy.; Remark: Prolactin (PRL) is essential for progesterone biosynthesis and luteal cell hypertrophy of the rat corpus luteum during pregnancy.; Title: similarity to ovarian-specific phosphoprotein PRAP - Rattus norvegicus; See PMID 8663045
An12g09710	Title: weak similarity to hypothetical protein SCH63.38 - Streptomyces coelicolor
An12g09720	Function: Ecm10 is involved in protein folding and assembling/disassembling of protein complexes.; Remark: Besides Ssc1 and Ssq1, Ecm10 is the third Hsp70 protein identified in the mitochondrial matrix.; Similarity: Ecm10 belongs to the heat shock protein 70 (Hsp70) superfamily.; Title: similarity to dnaK-type molecular chaperone Ecm10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11150530
An12g09750	Title: strong similarity to hypothetical protein CAD70289.1 - Neurospora crassa
An12g09760	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An12g09770	Function: Bfr1+ serves as an efflux pump that confers resistance to brefeldin A and various antibiotics.; Similarity: Bfr1+ protein is a member of the ATP-binding cassette superfamily.; Similarity: The bfr1+ protein exhibits significant homology in primary and secondary structures with two multidrug resistance gene products of S. cerevisiae, Snq2 and Sts1/Pdr5/Ydr1.; Similarity: The structural characteristic of bfr1+ protein resembles that of mammalian P-glycoprotein, which is responsible for multidrug resistance in tumor cells.; Title: similarity to brefeldin A resistance protein bfr1p - Schizosaccharomyces pombe; See PMID 7883711
An12g09780	Title: weak similarity to alkyl salicylate esterase salE - Acinetobacter sp.
An12g09810	Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH.; Function: AdhT catalyzes the oxidation of primary and secondary alcohols to aldehydes and ketones,respectively, by NAD+.; Pathway: Alcohol degradation.; Remark: AdhT is a zinc-metalloprotein.; Similarity: The deduced protein sequence of adhT shows significant similarity with the highly thermostable ADH from the thermoacidophilic archaebacterium Sulfolobus solfataricus.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 8020473
An12g09820	Title: strong similarity to hypothetical protein encoded by An13g03360 - Aspergillus niger
An12g09830	Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor
An12g09850	Title: weak similarity to cell wall protein Crh1 -Saccharomyces cerevisiae
An12g09860	Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa
An12g09870	Remark: it looks like only a glycin, prolin rich region.
An12g09880	Catalytic activity: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.; Pathway: cysteine metabolism; selenoamino acid metabolism; sulfur metabolism.; Remark: a pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.; Remark: the rcs2 transcript of Oryza sativa accumulated in shoots grown in the light, but disappeared almost completely by dark treatment.; Title: strong similarity to cysteine synthase rcs2 -Oryza sativa; See PMID 10095115
An12g09890	Title: similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger
An12g09900	Remark: amino acid transporters are essential participants in the resource allocation processes that support plant growth and development.; Remark: the transporter designated BAT1 (b(0,+)-type amino acid transporter 1) from rat kidney was found to be structurally related to recently identified amino acid transporters for system L, system y(+)L, and system x(-)C, which are linked, via a disulfide bond, to the other type II membrane glycoprotein, 4F2hc (4F2 heavy chain).; Title: strong similarity to amino acid transporter BAT1 - Rattus norvegicus; See PMID 10506124; See PMID 10748260
An12g09910	Remark: the Nudix family proteins, are fused to other domains and form multidomain proteins whose functions are known or could be predicted seem to be related to stress-response and elimination of damage products.; Similarity: to Nudix (MutT) family of pyrophosphohydrolases.; Title: similarity to mutator MutT/nudix family protein DR0329 - Deinococcus radiodurans; See PMID 11145417
An12g09920	Remark: weak similarity to Porphorymonas gingivalis protein PG123 patent WO9929870-A1.; Title: weak similarity to PG123 from patent WO9929870-A1 - Porphorymonas gingivalis
An12g09930	Remark: weak similarity to Vesicular stomatitis virus G stem polypeptide patent WO9932648-A1.; Title: weak similarity to virus G stem polypeptide from patent WO9932648-A1 - Vesicular stomatitis; See PMID 2168974
An12g09940	Catalytic activity: stearoyl-CoA + AH2 + O2 = oleoyl-CoA + A + 2 H2O.; Remark: delta 9-desaturase gene (Ole1), codes for a key enzyme involved in regulating membrane fluidity in animal cells and microorganisms.; Title: strong similarity to stearoyl-CoA desaturase ole1 - Ajellomyces capsulatus; See PMID 8538376
An12g09950	Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: ADH is a zinc protein. It acts on primary or secondary alcohols or hemiacetals; the animal, but not the yeast, enzyme acts also on cyclic secondary alcohols. The insect enzyme is a member of the nonmetallo-short-chain alcohol dehydrogenase (ADH) family.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 10971204; See PMID 1735726
An12g09960	Title: strong similarity to hypothetical protein encoded by An12g02190 - Aspergillus niger
An12g09970	Title: similarity to hypothetical protein encoded by An12g02180 - Aspergillus niger
An12g09980	Remark: only a smalll part of the protein match the sequence.; Title: weak similarity to zinc-binding protein Rar1 - Toxoplasma gondii; See PMID 10571178
An12g09990	Title: similarity to hypothetical protein encoded by An16g06080 - Aspergillus niger
An12g10000	Remark: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An12g10020	Catalytic activity: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2.; Remark: aao from Pleurotus eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Remark: aryl-alcohol oxidase is a unique flavoprotein with 15% carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; See PMID 1425667
An12g10030	Remark: rev7 is involved in polarity establishment/cellular polarization during budding.; Title: weak similarity to membrane protein YIL140w Rev7 - Saccharomyces cerevisiae; See PMID 7871890
An12g10050	Remark: can be used in a method to produce aromatic hydrocarbons, particularly catechol which is used in the development of pharmaceuticals such as L-DOPA and adrenaline, agrobiochemicals such as carbofuran, and antioxidants such as 4-tert-butyl catechol and veratol.; Remark: similarity to Aspergillus niger 2,3-dihydroxybenzoic acid decarboxylase patent WO9909048-A1.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger
An12g10060	Remark: also show homology to different oxidoreductases.; Remark: strong similarity to human breast tumour-associated protein 77 patent DE19813839-A1.; Title: strong similarity to breast tumour-associated protein 77 from patent DE19813839-A1 - Homo sapiens
An12g10090	Catalytic activity: L-2-Aminoadipate 6-semialdehyde + NAD+ or NADP+ + H2O = L-2-Aminoadipate + NADH or NADPH.; Pathway: sixth step in lysine biosynthesis; lysine degradation.; Remark: lys2 from S. cerevisiae catalyzes the activation of 2-aminoadipate by ATP-dependent adenylation,and the reduction of activated 2-aminoadipate. Together with lys5 protein, it catalyzes the overall interconversion of 2-aminoadipate and 2-aminoadipic-2-semialdehyde. It may be a component of the enzyme complex L-aminoadipate-semialdehyde dehydrogenase.; Title: strong similarity to L-aminoadipate-semialdehyde dehydrogenase Lys2 -Saccharomyces cerevisiae; See PMID 2013406; See PMID 7900426
An12g10100	Title: strong similarity to hypothetical membrane protein YDL144c - Saccharomyces cerevisiae
An12g10110	Remark: ARGR2 from yeast is a positive and negative regulator of many arginine-responsive genes.; Remark: there is evidence that ArgRII is the sensor of the effector arginine and that the binding site of arginine would be the region downstream from the zinc cluster, sharing some identity with the arginine binding domain of bacterial arginine repressors.; Similarity: to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to transcription factor Arg81 -Saccharomyces cerevisiae; See PMID 3709534; See PMID 10688655
An12g10120	Remark: adducin is a ubiquitously expressed membrane-skeletal protein localized at spectrin-actin junctions that binds calmodulin and is an in vivo substrate for protein kinase C (PKC) and Rho-associated kinase.; Remark: the human adducin is approximately 400 amino acids longer.; Similarity: to adducins of different organisms.; Title: strong similarity to adducin alpha chain (splice form 1) ADD1 - Homo sapiens; See PMID 10950304; See PMID 1840603
An12g10130	Remark: prnB A. nidulans, encoding the major proline transport system is one of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Remark: the proline utilisation gene cluster of Aspergillus nidulans can be repressed efficiently only when both repressing nitrogen and repressing carbon sources are present.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; See PMID 2664423; See PMID 8437566
An12g10140	Catalytic activity: (S)-2-hydroxy acid + O2 = 2-oxo acid + h2O2.; Pathway: Glyoxylate and dicarboxylate metabolism.; Remark: the IRE-like sequence in mouse GOX exhibited strong binding to IRPs at room temperature.; Title: strong similarity to glycolate oxidase GOX -Mus musculus; See PMID 9891009
An12g10150	Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism.; Remark: flavoprotein(FAD). Acts on primary amines,and usually also on some secondary and tertiary amines.; Remark: trout MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA).; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446
An12g10160	Title: similarity to hypothetical UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase C1galt1 - Rattus norvegicus
An12g10170	Title: weak similarity to hypothetical PxORF73 peptide Pxorf73 - Plutella xylostella
An12g10180	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An12g10190	Remark: Tna1p is necessary for nicotinic acid import into the cell.; Similarity: belongs to the allantoate permease family; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An12g10200	Remark: the protein shows partial homology to ice nucleation proteins.; Title: weak similarity to ice nucleation gene inaX -Xanthomonas campestris; See PMID 2259339
An12g10210	Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An12g10220	Function: oxidation of leucoanthocyanidins into anthocyanidins.; Pathway: flavonoid synthesis; anthocyanidins biosynthesis.; Remark: steady-state level of mRNAs encoded by the flavonoid biosynthetic genes as determined in young seedlings is coordinately induced by light.; Similarity: belongs to the iron/ascorbate-dependent family of oxidoreductases.; Title: similarity to leucoanthocyanidin dioxygenase LDOX - Vitis vinifera; See PMID 8193299
An12g10230	Remark: atf21 regulates meiosis and mitosis in fission yeast by two branches of a MAP kinase cascade.; Title: similarity to ATF/CREB-family transcription factor atf21p - Schizosaccharomyces pombe; See PMID 8824587; See PMID 10102365
An12g10240	Remark: expression of the con-10 gene in various mutants defective at different stages of conidiation indicates that it plays a role after aerial hyphal development.; Title: strong similarity to conidiation-specific protein pCon-10a - Neurospora crassa; See PMID 2970007
An12g10250	Catalytic activity: Phenol + NADPH + O2 = Catechol + NADP+ + H2O.; Pathway: phenylalanine metabolism; toluene degradation.; Remark: southern blot analysis revealed the presence of phenol hydroxylase gene-related sequences in a number of T. cutaneum and Trichosporon beigelii strains and in Cryptococcus elinovii but not in Trichosporon pullulans,Trichosporon penicillatum, or Candida tropicalis.; Title: strong similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434
An12g10270	Catalytic activity: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.; Pathway: propanoate metabolism.; Remark: comparative analysis of structural and expression characteristics of ACC synthase genes from Arabidopsis and other plant species suggests that the sequence divergence of the ACC synthase genes and possibly the distinct regulatory networks governing the expression of ACC synthase subfamilies arose early in plant evolution and before the divergence of monocots and dicots.; Title: similarity to 1-aminocyclopropane-1-carboxylate synthase ACS1 -Arabidopsis thaliana; See PMID 8566772; See PMID 1438312
An12g10280	Remark: the protein seems approximately N-terminal 200 amino acids shorter.; Title: similarity to hypothetical protein 1A9.40 -Neurospora crassa
An12g10290	Phenotype: mutations in S. cerevisiae HOL1 confer the ability of cells to take up histidinol from the medium.; Similarity: to ion transporters similar to the major facilitator superfamily of transporters.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 2405251; See PMID 8955402
An12g10300	Remark: only a part of the protein match to serine/threonine protein kinase-like protein in Arabidopsis thaliana.
An12g10320	Function: high affinity zinc transport protein.; Remark: also strong similarity to metal-regulated transporter polypeptide ZRT2 in Arabidopsis thaliana patent WO9745000-A1.; Similarity: to other zinc transport proteins of Arabidopsis thaliana, Schizosaccharomyces pombe.; Title: strong similarity to high affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; See PMID 8322518
An12g10330	Remark: N-terminal truncated ORF due to end of contig.; Title: weak similarity to hypothetical protein encoded by An02g14500 - Aspergillus niger [truncated ORF]
An12g10340	Similarity: shows similarity to N-terminal half of purine-cytosine permease homolog yxlA of B. subtilis and to N-terminal half of hypothetical proteins of M. pneumoniae and M . genitalium. .; Title: weak similarity to hypothetical purine-cytosine permease homolog yxlA - Bacillus subtilis
An12g10350	Title: strong similarity to hypothetical protein encoded by An15g07090 - Aspergillus niger
An12g10360	Title: similarity to hypothetical protein encoded by An08g08280 - Aspergillus niger
An12g10380	Catalytic activity: chitin synthase catalyzes the conversion of UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Function: chitin synthase catalyzes the alpha-1,4-glycosylation of chitin by UDP-N-acetyl-D-glucosamine producing elongated chitin and UDP.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus
An12g10390	Function: The tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An12g10400	Similarity: shows similarity to C-terminal part of PA1406 of P. aeruginosa.; Title: similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger
An12g10410	Catalytic activity: UDPglucose = UDPgalactose.; Pathway: galactose metabolism; nucleotide sugars metabolism.; Remark: the enzyme requires NAD+. Also acts on UDP-2-deoxyglucose.; Title: strong similarity to UDP-Glc-4-epimerase galE - Escherichia coli; See PMID 10531250
An12g10420	Remark: spherulin 4 from Physarum polycephalum accumulates during spherulation.; Title: similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775
An12g10430	Remark: it seems that there has been an gene duplication with 22CK but the similarity here is much better.; Remark: spherulin 4 from Physarum polycephalum accumulates during spherulation.; Title: strong similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775
An12g10440	Title: strong similarity to hypothetical protein CAD70539.1 - Neurospora crassa
An12g10450	Title: weak similarity to hypothetical protein SCC88.10c - Streptomyces coelicolor
An12g10460	Title: weak similarity to hypothetical protein encoded by Orf10 - Yersinia enterocolitica
An12g10470	Remark: only repetitive sequences are shown homology.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens
An12g10480	Remark: C-terminal truncated ORF due to end of contig.; Remark: the SEN1 gene, which is essential for growth in the yeast S. cerevisiae, is required for endonucleolytic cleavage of introns from all 10 families of precursor tRNAs.; Title: similarity to protein Sen1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1569945
An12g10490	Title: weak similarity to WbpV - Pseudomonas aeruginosa; See PMID 10627048
An12g10500	Remark: also strong similarity to patent FR2728905-A1 which is also the stereospecific, heat-stable amino acid amidohydrolase from B. stearothermophilus.; Remark: the deacetylating capacity of purified aminoacylase Bacillus stearothermophilus varies considerably depending on the nature of the amino acid residue in the substrate.; Similarity: belongs to peptidase M40, also known as the AMA/HIPO/HYUC family of hydrolases.; Title: strong similarity to N-carbamyl-L-amino acid amidohydrolase amaB - Bacillus stearothermophilus; See PMID 8285691; See PMID 9023955
An12g10510	Remark: the predicted ORF probably encodes a fusion protein between a acetylornithine deacetylase (EC 3. 5. 1. 16) (C-terminal) and a dehydratase (N-terminal), as the predicted ORF has a 359 amino acid extention at the N-terminus compaired to argE of M. xanthus, which shows similarity to threonine dehydratases (EC 4. 2. 1. 16).; Title: similarity to acetylornithine deacetylase argE - Myxococcus xanthus; See PMID 8092856; See PMID 9829957
An12g10520	Remark: Meis1 from Homo sapiens encodes a homeobox protein belonging to the TALE (three amino acid loop extension) family of homeodomain-containing proteins.; Remark: the similarity is only in the homeodomain in the found proteins.; Similarity: belongs to the TALE/MEIS family of homeobox proteins.; Title: similarity to Meis1-related protein 2 MRG2 -Homo sapiens; See PMID 9049632
An12g10530	Title: similarity to kinesin light chain KLC -Plectonema boryanum
An12g10540	Similarity: shows similarity to N-terminal part of mrsA of M. tuberculosis.; Title: weak similarity to hypothetical phosphoglucomutase or phosphomannomutase mrsA -Mycobacterium tuberculosis
An12g10550	Similarity: shows similarity to several sensor/response regulator proteins, the similarity is restricted to the His Kinase A phosphoacceptor domain and Histidine kinase-ATPase domain.; Title: similarity to histidine protein kinase/response regulator luxQ - Vibrio harveyi
An12g10560	Similarity: aminoacids 5-257 show similarity to N-terminal half of S. cerevisiae Gal80p.; Similarity: shows similarity to several oxidoreductases.; Title: similarity to negative regulator for expression of galactose-induced genes Gal80 - Saccharomyces cerevisiae
An12g10570	Title: weak similarity to hypothetical isoflavone reductase homolog F18A5.50 - Arabidopsis thaliana
An12g10580	Title: similarity to hypothetical protein 4 -Streptomyces coelicolor
An12g10610	Similarity: shows similarity to several dihydroflavonol an cinnamoyl-coA reductases.; Title: similarity to aldehyde reductase ARII -Sporidiobolus salmonicolor; See PMID 10583966
An12g10620	Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An12g10630	Catalytic activity: acid phosphatase catalyzes the conversion of an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Title: similarity to acid phosphatase aphA -Aspergillus ficuum
An12g10640	Similarity: shows similarity to several hydroxyisoflavone reductases.; Title: similarity to 2-hydroxyisoflavone reductase IRL - Zea mays
An12g10650	Title: weak similarity to hypothetical protein DR0722 - Deinococcus radiodurans
An12g10660	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the ORF shows similarity to several transcriptional activators.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus
An12g10670	Title: similarity to hypothetical lyase SC7E4.19 -Streptomyces coelicolor
An12g10680	Similarity: shows strong similarity to several hypothetical monooxygenases and epoxigenases of different organisms.; Title: strong similarity to hypothetical monooxygenase paxM - Penicillium paxilli; See PMID 11169115
An12g10700	Title: similarity to hypothetical protein SPAC1952.10c - Schizosaccharomyces pombe
An12g10710	Title: strong similarity to hypothetical protein SPAC869.06c - Schizosaccharomyces pombe
An12g10720	Catalytic activity: catalase catalyzes the converison of 2 H2O2 = O2 + 2 H2O.; Similarity: shows strong similarity to several catalases of different species.; Title: strong similarity to catalase kat -Methanosarcina barkeri; See PMID 10382262
An12g10730	Title: strong similarity to hypothetical protein AAO51653.1 - Dictyostelium discoideum
An12g10740	Similarity: similarity hypothetical protocatechuate 3,4-dioxygenase beta chain of Streptomyces cover the N-terminal 300 aminoacids.; Title: similarity to hypothetical exported protein YPO0987 - Yersinia pestis
An12g10750	Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans
An12g10760	Title: similarity to hypothetical protein YPL146c -Saccharomyces cerevisiae
An12g10770	Catalytic activity: aao uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Pathway: aao is involved in lignin degradation by Pleurotus pulmonarius.; Remark: the purified aao is an extracellular glycoprotein with 14% N-carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; extracellular/secretion proteins; See PMID 10606774
An12g10780	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: strong similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An12g10790	Title: strong similarity to hypothetical oxidase dotB - Mycosphaerella pini
An12g10810	Remark: the mRNA sequence of cDNA clone 2678 shows 100 percent identity to the genomic DNA.; Similarity: the ORF encoded protein shows a significant selfblast hit to the hypothetical protein An06g00160 from Aspergillus niger.; Title: strong similarity to EST an_2678 -Aspergillus niger
An12g10830	Induction: mRNA of binA from A. nidulans was induced by bafilomycin.; Remark: the ORF shows also a match with the A. niger EST SEQ ID NO:4020 from patent WO200056762-A2.; Title: similarity to hypothetical protein EAA74834.1 - Gibberella zeae
An12g10850	Function: macrophomate synthase from the fungus Macrophoma commelinae is a Mg(II)-dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical transformation from 2-pyrone and oxalacetate to benzoate involving decarboxylation, C-C bond formation, and dehydration.; Induction: oxalacetate inhibits the enzyme activity at a concentration higher than 5 mM, and magnesium chloride stimulates the enzyme activity.; Title: strong similarity to macrophomate synthase -Macrophoma commelinae; See PMID 10731719; See PMID 10984474
An12g10860	Function: lys2 catalyzes both the activation and reduction of alpha-aminoadipic acid to its semialdehyde.; Similarity: lys2 belongs to the superfamily of acyladenylate-forming enzymes.; Title: similarity to aminoadipate reductase enzyme lys2 - Acremonium chrysogenum; See PMID 11254122
An12g10870	Title: similarity to hypothetical acetyltransferase 2SCG4.07c - Streptomyces coelicolor
An12g10890	Title: weak similarity to dehydrogenase LovC from patent WO200037629-A2 - Aspergillus terreus
An12g10900	Title: weak similarity to tropinone reductase II TRN2 - Datura stramonium
An12g10910	Function: lovC from A. terreus is essential for formation of 4a,5-dihydromonacolin L.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 11386351; See PMID 11412974
An12g10920	Title: similarity to protein cognate of protein kinase C-theta from patent WO9714038-A1 - Homo sapiens
An12g10930	Title: similarity to hypothetical protein encoded by An12g10570 - Aspergillus niger
An12g10940	Title: questionable ORF
An12g10950	Title: similarity to guanine nucleotide-specific ribonuclease Po1 - Pleurotus ostreatus; See PMID 7798182
An12g10960	Remark: C-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein encoded by An03g02680 - Aspergillus niger [truncated ORF]
An15g00010	Complex: Sec15p of S. cerevisiae and six other proteins (Sec6p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) together form the exocyst complex.; Function: Sec15p of S. cerevisiae and six other proteins (Sec6p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) function together in a complex (exocyst) required for exocytosis, and not other intracellular trafficking steps.; Localization: the exocyst of S. cerevisiae is specifically located at sites of vesicle fusion at the tip of the bud.; Remark: C-terminally truncated ORF due to end of contig.; Title: strong similarity to exocyst complex vesicular traffic control protein Sec15 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10873817; See PMID 8978675
An15g00020	Complex: Mei2p of S. pombe also binds to the novel WD-repeat protein Mip1p, which facilitates function of the meiotic regulator Mei2p.; Complex: Mei2p of S. pombe binds to a polyadenylated RNA molecule, meiRNA, loss of which blocks meiosis I.; Function: mei2 of S. pombe is required also for meiosis I.; Function: mei2 of S. pombe, which is essential but not sufficient for the initiation of premeiotic DNA synthesis, encodes an RNA-binding protein.; Localization: binding of Mei2p of S. pombe to mRNA is necessary for nuclear localization of Mei2p.; Repression: the expression of mei2 of S. pombe is negatively regulated by cAMP.; Title: similarity to meiotic RNA-binding protein mei2p - Schizosaccharomyces pombe; See PMID 2840284; See PMID 7520368; See PMID 9778252
An15g00025	Title: strong similarity to hypothetical protein EAA57835.1 - Aspergillus nidulans
An15g00030	Function: Las21p of S. cerevisiae participates in extracellular/cell surface phenomena.; Function: the major facilitator super family is the largest family of secondary transport carriers and each newly identified family has been shown to exhibit specificity for a single class of substrates.; Remark: Las21 is a synonymous name for Yj1062W.; Remark: the N-terminal of An15g00030 shows high similarity to regions conserved in many phosphodiesterases and nucleotide pyrophosphatases as shown by alignment with Pig-o - Mus musculus.; Similarity: Las21 (Yj1062W) of S. cerevisiae is a member of the major facilitator super family, possessing multimembrane spanning domains.; Title: strong similarity to member of the major facilitator superfamily Las21 - Saccharomyces cerevisiae; plasma membrane; See PMID 10734606; See PMID 10781593; See PMID 10943556
An15g00040	Remark: N-terminal half shows similarity to YBL028c of S. cerevisiae; S. cerevisiae YBL028c is 100 aa shorter.; Remark: YBL028c of S. cerevisiae has been classified as mating type regulating protein by the MIPS database,but no supporting literature was found.; Title: similarity to hypothetical protein YBL028c -Saccharomyces cerevisiae
An15g00050	Function: SIZ1 of S. cerevisiae is required for septin-sumoylation where together with the SUMO1/Smt3-ligase it acts as an adaptor between the conjugating enzyme and substrates.; Remark: SIZ1 of S. cerevisiae is also known as YDR409W.; Remark: the function of SIZ1 in S. cerrevisiae may contribute to the regulation of chromatin structure and chromosome maintenance.; Similarity: SIZ1 of S. cerevisiae is a member of the PIAS family that contain a zinc-binding RING domain.; Title: strong similarity to an E3-like factor Siz1 -Saccharomyces cerevisiae; See PMID 11333221; See PMID 11572779; See PMID 11577116; See PMID 11587849
An15g00060	Complex: TRAPP (transport protein particle) of S. cereviesiae is a multiprotein complex containing ten subunits, Bet5p, Trs20p, Bet3p, Trs23p, Trs33p,Trs31p,Trs65p, Trs85p, Trs120p and Trs130p.; Function: targeting of ER vesicles to Golgi.; Golgi; Remark: Trs33p of S. cerevisiae is N-terminally 50 AA longer.; Remark: Trs33p of S. cerevisiae is a 33 kDa subunit of TRAPP.; Remark: the systematic name for Trs33p of S. cerevisiae is YOR115c.; Title: strong similarity to TRAPP complex subunit involved in targeting and fusion of ER transport vesicles to golgi Trs33 - Saccharomyces cerevisiae; See PMID 10698928
An15g00070	Catalytic activity: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and also oxidizes some other 2-hydroxydicarboxylic acids.; Function: malat-dehydrogenase catalyzes the conversion of oxaloacetate and malate.; Localization: normally mitochondrial, but some plant isoforms are localized in the glyoxisome.; Similarity: shows also strong similarity to cytosolic mdh from Piromyces sp. E2.; Title: strong similarity to malate dehydrogenase precursor MDH - Mus musculus; localisation:mitochondrion; See PMID 9834842
An15g00080	Complex: L28 of R. norvegicus is a component of the 60S fragment of the ribosome.; Function: the ribosome translates mRNA into protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L28 - Rattus norvegicus; cytoplasm; See PMID 2207170
An15g00090	Title: similarity to hypothetical protein SPAC1687.07 - Schizosaccharomyces pombe
An15g00100	Complex: in addition to the RNA-binding activity of the human SAP 49, this protein is associated specifically with U2 snRNP and the U2 snRNP-associated spliceosomal protein SAP 145.; Function: SAP 49 of H. sapiens is associated specifically with U2 snRNP and binds to a region in the pre-mRNA immediately upstream of the branchpoint sequence in the prespliceosomal complex A.; Title: strong similarity to splicosome associated protein SAP49 - Homo sapiens; nucleus; See PMID 7958871
An15g00110	Function: FLX1 from S. cerevisiae is involved in maintaining the balance of flavin nucleotides in mitochondria.; Function: FLXI from S. cerevisiae is a flavin adenine dinucleotide transporter, maintaining a normal ratio of FAD/FMN in mitochondria.; Localization: FLXI from S. cerevisiae is localized to the inner membrane of mitochondria.; Title: strong similarity to mitochondrial FAD carrier protein Flx1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8631763
An15g00120	Function: WT1 from H. sapiens recognises and binds to the DNA sequence 5'-CGCCCCCGC-3'.; Function: WT1 proteins from H. sapiens act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and -repression.; Remark: proteins from data banks are N-terminally longer (approx. 100 AA).; Similarity: shows similarity to various Zn-finger proteins but strongest similarity to WT1 - H. sapiens.; Title: similarity to Wilms tumor susceptibility protein WT1 - Homo sapiens; See PMID 10333728
An15g00130	Remark: shows weak similarity to N-terminal half of cytidylate kinase CP0181 Chlamydophila pneumoniae.; Title: questionable ORF
An15g00140	Complex: in S. cerevisiae Tup1 forms a complex with Ssn6 and Histone H3 and H4.; Function: Tup1 from S. cerevisiae interacts directly with histones H3 and H4 to act as general repressor of transcription.; Function: the Ssn6-Tup1 complex from S. cerevisiae likely actively recruits deacetylase activities to deacetylate adjacent nucleosomes and promote Tup1-histone interaction.; Similarity: Roc1 from Candida albicans and TupA from Aspergillus nidulans also show strong similarity.; Title: similarity to transcription repressor Tup1 -Saccharomyces cerevisiae; nucleus; See PMID 10871883; See PMID 11069890
An15g00150	Function: this enzyme introduces a C-5 double bond in the B ring of ergosterol.; Remark: the C5-sterol desaturase is required for ergosterol biosynthesis in yeast.; Title: strong similarity to C-5 sterol desaturase Erg3 - Saccharomyces cerevisiae; See PMID 1864507; See PMID 10514567; See PMID 10933640
An15g00160	Remark: GCR3 is involved in the expression of glycolytic genes.; Title: strong similarity to transcription regulator CaGCR3 - Candida albicans; See PMID 10206191
An15g00170	Function: Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3.; Function: glycogen synthase kinase 3 (GSK-3) family is involved in cell fate determination, nuclear signalling,and hormonal regulation in higher eukaryotes.; Title: strong similarity to protein kinase skp1p -Schizosaccharomyces pombe; See PMID 8524294; See PMID 9064503
An15g00190	Title: strong similarity to mitochondrial import receptor MOM38 - Neurospora crassa; localisation:mitochondrion
An15g00200	Remark: the H. sapiens PFKFB4 product encodes bifunctional enzyme 6-Phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2/FBPase-2), responsible for the synthesis and breakdown of Fru-2,6-P2, a key metabolite in the regulation of glycolysis.; Title: similarity to 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase PFKFB4 - Homo sapiens; See PMID 10095107
An15g00210	Remark: the systematic genename of ELP2 is YGR200C.; Title: strong similarity to elongator complex and elongating RNA pol II holoenzyme 90 kDa subunit Elp2 -Saccharomyces cerevisiae; See PMID 10777588
An15g00220	Remark: the homologe S. pombe SPAC20G4. 01 protein sequence is fragmented (see database entry).; Title: strong similarity to hypothetical ATP-dependent transporter SPAC20G4.01 - Schizosaccharomyces pombe
An15g00230	Catalytic activity: tRNA isopentenyltransferases catalyze the conversion of isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine.; Title: strong similarity to tRNA isopentenyltransferase Mod5 - Saccharomyces cerevisiae
An15g00240	Function: Rai1p (Rat1p interacting protein 1) of S. cerevisisae is required for normal 5. 8S rRNA processing.; Function: S. cerevisisae rai1 deletion mutant indicated a defect in 60S rRNA biogenesis.; Remark: the systematic genename of RAI1 of S. cerevisiae is YGL246c.; Title: strong similarity to nuclear exoribonuclease binding protein Rai1 - Saccharomyces cerevisiae; See PMID 10805743
An15g00250	Title: strong similarity to hypothetical protein YOR164c - Saccharomyces cerevisiae
An15g00270	Complex: human replication factor C is a heteropentamer of subunits of 140/145, 40, 38, 37, and 36. 5 kD that forms a complex with proliferating cell nuclear antigen (PCNA) in the presence of ATP.; Function: the 40 kd subunit of human replication factor C binds ATP. replication factor C and PCNA are necessary for the elongation of primed DNA templates by DNA polymerase delta and epsilon.; Similarity: the predicted A. niger protein shows strong similarity to human 40 kD subunit of replication factor C (RFC2), which is also known as activator 1.; Title: strong similarity to 40 kD subunit of replication factor C RFC2 - Homo sapiens; nucleus
An15g00280	Title: strong similarity to hypothetical protein jhp0295 - Helicobacter pylori
An15g00290	Catalytic activity: A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 6769897
An15g00300	Function: the Aspergillus oryzae amyR protein binds to DNA as a homodimer, which is responsible for starch/maltose induction of amylolytic genes.; Remark: similarity corresponds only to central region of homologous protein.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498
An15g00310	Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An15g00320	Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranoside.; Remark: the purified A. niger enzyme hydrolyses sucrose and raffinose but there was no detectable hydrolysis of inulin, melezitose or PNPG.; Title: strong similarity to beta-fructofuranosidase precursor suc1 - Aspergillus niger
An15g00330	Title: strong similarity to glycoprotein-associated amino acid transporter b0,+AT1 - Mus musculus; plasma membrane; See PMID 8631857; See PMID 10588648
An15g00340	Function: protein involved in import of cytochrome c into mitochondria in yeast.; Title: similarity to mitochondrial import factor of cytochrome c Cyc2 - Saccharomyces cerevisiae
An15g00350	Catalytic activity: 2-Hydroxybutane-1,2,4-tricarboxylate = But-1-ene-1,2,4-tricarboxylate + H2O.; Function: responsible for the dehydration of cis-homoaconitate to homoisocitrate acid.; Pathway: third step in lysine biosynthesis.; Title: strong similarity to homoaconitate hydratase lYSF - Aspergillus nidulans; localisation:mitochondrion
An15g00360	Remark: similarity corresonds only to the N-terminal region, which binds integral membrane proteins. The acidic C-terminal 'regulatory' domain contains an alternatively spliced sequence.; Title: similarity to ankyrin ANK1 - Homo sapiens; See PMID 2137557
An15g00380	Function: MSS1 of S. cerevisiae works in association with the small subunit of mitoribosomes and seems to play some part in mitochondrial translation.; Title: strong similarity to mitochondrial GTPase Mss1 - Saccharomyces cerevisiae; See PMID 8392589; See PMID 9774408
An15g00390	Function: sepA function in A. nidulans requires a preceding mitosis; sepA acts prior to actin ring formation during septation in A. nidulans.; Remark: the A. nidulans sepA gene encodes a member of the FH1/2 protein family, which appear to have roles in morphogenesis and cytokinesis in yeast and Drosophila.; Title: strong similarity to cytokinesis protein sepA - Aspergillus nidulans; See PMID 8150280
An15g00400	Title: similarity to hypothetical protein CAD70967.1 - Neurospora crassa
An15g00410	Function: insertional inactivation of A. nidulans aciA did not reveal an altered phenotype. Acetate inducibility of aciA was found to be dependent on the amdA regulatory gene.; Remark: strong similarity also to formate dehydrogenases (EC 1. 2. 1. 2).; Title: strong similarity to acetate-inducible gene aciA - Aspergillus nidulans; See PMID 3916805
An15g00420	Catalytic activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).; Title: strong similarity to mitochondrial leucine--tRNA ligase leu-5 - Neurospora crassa; localisation:mitochondrion; See PMID 4940374
An15g00430	Title: questionable ORF
An15g00440	Remark: homology corresponds to multiple serine repeats.
An15g00450	Title: strong similarity to hypothetical protein SPBC16A3.10 - Schizosaccharomyces pombe
An15g00460	Function: h1Vps45 is believed to be implicated in vesicular transportation from Golgi to vacuole.; Function: the protein is necessary for the correct sorting and delivery of vacuolar hydrolases.; Title: strong similarity to vacuolar protein sorting protein hlVps45 - Homo sapiens; See PMID 10404641
An15g00470	Function: in A. nidulans the hypA gene is required for multiple aspects of hyphal morphogenesis.; Remark: hyp mutants have aberrant patterns of septation and show defects in polarity establishment and tip growth in A. nidulans.; Title: strong similarity to hypercellular protein hypA - Aspergillus nidulans; See PMID 10049919
An15g00480	Title: strong similarity to hypothetical protein 99H12.140 - Neurospora crassa
An15g00490	Complex: The Mediator complex is composed of two subcomplexes, the Rgr1 and Srb4 subcomplexes, which appear to function in the reception of activator signals and the subsequent modulation of Pol II activity, respectively; Complex: the Med6-containing subcomplex is composed of: Srb4p, Srb2p, Srb5p, Srb6p, Med6p, Rox3p.; Complex: the Rgr1-associated subcomplex is composed of : Rgr1p, Gal11p, Sin4p, Med3p, Srb7p, Med1p, Med4p,Med7p, Med8p, Med9p.; Function: Med6p of S. cerevisiae is subunit of the multisubunit Mediator complex which is required for most RNA polymerase II (Pol II) transcription.; Remark: the systematic genename of MED6 is YHR058C.; Title: strong similarity to RNA pol II transcription mediator Med6 - Saccharomyces cerevisiae; See PMID 9234719; See PMID 9671455; See PMID 9710620; See PMID 9891034
An15g00500	Title: strong similarity to hypothetical protein YJL055w - Saccharomyces cerevisiae
An15g00510	Catalytic activity: the proteasome has an ATP-dependent proteolytic activity.; Function: the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph.; Pathway: is involved in an atp/ubiquitin-dependent non-lysosomal proteolytic pathway.; Title: strong similarity to proteasome 20S subunit C2 - Rattus norvegicus; See PMID 2335242; See PMID 2819072
An15g00520	Title: strong similarity to hypothetical membrane protein YJR044c - Saccharomyces cerevisiae
An15g00540	Title: strong similarity to hypothetical protein B13O20.120 - Neurospora crassa
An15g00550	Title: strong similarity to hypothetical protein YBR101c - Saccharomyces cerevisiae
An15g00560	Title: strong similarity to actin gamma -Aspergillus nidulans; cytoskeleton; See PMID 2975248
An15g00570	Catalytic activity: the AIRS part of S. pombe ADE1 converts 1-(5-phospho-D-ribosyl)acetamidine to ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.; Catalytic activity: the GARS part of S. pombe ADE1 converts ATP + 5-phospho-D-ribosylamine + glycine to ADP + phosphate + N 1-(5-phospho-D-ribosyl)glycinamide.; Function: S. pombe ADE1 has glycinamide ribotide synthetase (GARSase) and aminoimidazole ribotide synthetase (AIRSase) enzyme activities which catalyse the 2nd and 5th steps, respectively, of the purine synthetic pathway. ATP + 2-(formamido)-N; Title: strong similarity to bifunctional purine synthase ade1p - Schizosaccharomyces pombe; See PMID 3502942
An15g00580	Function: Overexpression of PET127 completely blocked respiratory growth and caused cells to lose wild-type mitochondrial DNA, suggesting that too much Pet127p prevents mitochondrial gene expression.; Function: S. cerevisiae Pet127 is membrane bound and is involved in processing of the 5' ends of mitochondrial mRNAs.; Similarity: similarity is from the central region of the prediced A. niger protein to the N-terminal half of S. cerevisiae Pet127.; Title: strong similarity to mitochondrial mRNA processing protein Pet127 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10397341; See PMID 9111353
An15g00590	Function: human Nod2 is required for LPS-induced NF-kB activation and might be a cytosolic receptor for pathogen components.; Title: weak similarity to NOD2 - Homo sapiens; See PMID 11058605
An15g00600	Title: weak similarity to hypothetical protein CAD11363.1 - Neurospora crassa
An15g00610	Catalytic activity: imidazoleglycerolphosphate dehydratases convert D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.; Function: imidazoleglycerolphosphate dehydratases are required for histidine biosynthesis.; Regulation: expression of the igh gene in T. harzianum is not inhibited by external histidine and the level of igh mRNA was about threefold higher in cells starved of histidine.; Title: strong similarity to imidazoleglycerolphosphate dehydratase igh - Trichoderma harzianum; See PMID 1406594
An15g00630	Function: S. cerevisiae SUR1 is required for the mannosylation of inositolphosphorylceramide (IPC) to form mannosylinositolphosphorylceramide (MIPC).; Title: strong similarity to sphingolipid metabolism Sur1 - Saccharomyces cerevisiae; See PMID 9323360
An15g00640	Title: strong similarity to hypothetical protein GABA-A receptor epsilon subunit - Caenorhabditis elegans
An15g00650	Function: replacement histone H3. 2 genes of M. sativa may affect nucleosome assembly and chromatin repression.; Title: strong similarity to replacement histone H3.2 - Medicago sativa; nucleus; See PMID 8722568
An15g00660	Remark: the N-terminal 400 aa of the predicted A. niger protein show no similarity to other proteins, aa 400 to 800 show similarity to proline rich proteins and the remaining C-terminal region shows similarity to two hypothetical proteins from N. crassa and S. pombe respectevly.; Remark: the predicted A. niger protein potentially is N-terminally 800 aa too long.; Title: strong similarity to hypothetical protein 65E11.60 - Neurospora crassa
An15g00670	Remark: information regarding S. cerevisiae EHT1 has not been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Remark: the systematic name for S. cerevisiae EHT1 is YBR177c.; Title: strong similarity to alcohol acyl transferase Eht1 - Saccharomyces cerevisiae
An15g00680	Function: S. cerevisiae Loc1p is a double-stranded RNA-binding protein and is involved in localization of mRNA.; Function: S. cerevisiae Loc1p is required for the localization of transcriptional repressor ASH1 mRNA to the distal end of daughter cells during anaphase of the cell cycle.; Localization: by immunofluorescence S. cerevisiae Loc1p was observed to be a nuclear protein that did not shuttle between the nucleus and cytoplasm.; Remark: information regarding S. cerevisiae Loc1 has not been published and is available from http://www. ncbi. nlm. nih. gov/cgi-bin/Entrez/coglist?gi=34&cog=-,http://genome-www. stanford. edu/cgi-bin/SGD/genehunter and http://www. google. de/search?q=cache:www. wisc. edu/union/info/conf/rna/RNA2000_poster. pdf+loc1+cerevisiae&hl=de.; Title: strong similarity to RNA-binding protein Loc1 - Saccharomyces cerevisiae; nucleus
An15g00690	Title: strong similarity to 14.8 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 10940377; See PMID 8166654
An15g00700	Complex: in S. cerevisiae Rpc19p and Rpc40p form a heterodimer that may be a equivalent of alpha homodimers found in E. coli RNA polymerase.; Function: Rpc19p of S. cerevisiae is a shared subunit of RNA polymerases I and III.; Remark: YNL113W is the systematic name for RPC19.; Similarity: Rpc19p of S. cerevisiae belongs to the archaebacteria RPOL/eukaryotic RPB11/RPC19 RNA polymerase family.; Title: strong similarity to 16 kD subunit of DNA-directed RNA polymerase I,III Rpc19 - Saccharomyces cerevisiae; nucleus; See PMID 1869554
An15g00730	Title: strong similarity to hypothetical protein 99H12.280 - Neurospora crassa
An15g00740	Title: similarity to hypothetical protein SPBC1271.03c - Schizosaccharomyces pombe
An15g00750	Complex: elongation factor 1 is composed of four subunits: alpha, beta, delta, and gamma.; Function: elongation factor 1-gamma probably plays a role in anchoring the complex to other cellular components.; Remark: CAM1 and YPL048W are alternativ names for TEF3.; Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: strong similarity to elongation factor 1-gamma 1 Tef3 - Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 8041634
An15g00760	Function: Elongation factor 1 mediates the transport of aminoacyl-tRNA to 80S ribosomes. It is composed of three subunits, named alpha, beta and gamma.; Remark: the ORF encoded protein also shows strong similarity to a hypothetical protein in A. nidulans that might play a role in sterigmatocystin biosynthesis (PMID 8643646) and similarity to glutathione S-transferase of Issatchenkia orientalis (PMID 10217793).; Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: strong similarity to translation elongation factor eEF-1 gamma chain - Artemia sp. [truncated ORF]; cytoplasm; See PMID 3666137
An15g00770	Function: MRP-S9 of S. cerevisiae plays a role in assembly and/or function of the 30s subunit of yeast mitochondrial ribosomes.; Phenotype: S. cerevisiae cells disrupted in the chromosomal copy of MRP-S9 were unable to respire and displayed a characteristic phenotype of mutants with defects in mitochondrial protein synthesis as indicated by a loss of cytochrome c oxidase activity.; Remark: YBR146w is the systematic name for MRP-S9.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S9 - Saccharomyces cerevisiae; localisation:mitochondrion
An15g00780	Remark: HMD1 and YPL190C are alternative names for NAB3.; Title: weak similarity to RNA binding protein Nab3 -Saccharomyces cerevisiae
An15g00790	Title: similarity to hypothetical protein 82C3.050 -Neurospora crassa
An15g00800	Title: weak similarity to hypothetical protein encoded by An14g07230 - Aspergillus niger
An15g00810	Title: similarity to hypothetical zinc-finger protein CAC28841.2 - Neurospora crassa
An15g00820	Remark: blastp matches are due to repetitiv amino acids.; Title: weak similarity to Alpha-D-glucosyltransferase from patent WO9606173-A1 -Streptococcus salivarius
An15g00840	Catalytic activity: chitinase hydrolyses the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: chitodextrinase, 1,4-beta-poly-N-acetylglucosaminidase and poly-beta-glucosaminidase are alternative names for chitinase.; Title: strong similarity to chitinase - Chelonus sp.; See PMID 8063715
An15g00850	Title: similarity to hypothetical secreted hydrolase - Streptomyces avermitilis
An15g00860	Title: similarity to hypothetical protein CAD79655.1 - Neurospora crassa
An15g00870	Function: cnb-1 antisense expression caused increase in hyphal branching, changes in hyphal morphology and concomitant loss of the distinctive tip-high Ca2+ gradient typical for growing wild-type hyphae and finally growth arrest.; Function: cnb-1 of N. crassa has a specific role in the precise regulation of apical growth.; Title: strong similarity to calcineurin subunit B cnb-1 - Neurospora crassa; See PMID 9349701
An15g00880	Function: in D. melanogaster E(Pc) may have a wider role in chromatin formation or gene regulation than other Polycomb group genes.; Localization: in D. melanogaster E(Pc) is a chromatin protein, binding to polytene chromosomes at about 100 sites.; Phenotype: mutations in E(Pc) in D. melanogaster are strong enhancers of mutations in many Polycomb group genes and are also strong suppressors of position-effect variegation.; Title: similarity to polycomb protein enhancer E(Pc) - Drosophila melanogaster; See PMID 9735366
An15g00890	Remark: YDR257C is the systematic name for RMS1.; Title: strong similarity to hypothetical regulator protein Rms1 - Saccharomyces cerevisiae
An15g00900	Function: O-sialoglycoprotein endopeptidase does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.; Function: O-sialoglycoprotein endopeptidase of P. haemolytica specifically hydrolyzes O-linked sialoglycoproteins.; Similarity: O-sialoglycoprotein endopeptidase of P. haemolytica belongs to peptidase family M22.; Title: strong similarity to O-sialoglycoprotein endopeptidase - Pasteurella haemolytica; See PMID 9314606
An15g00910	Complex: the Snf1 kinase is a heterotrimeric enzyme composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a beta-subunit that mediates heterotrimer formation. S. cerevisiae encodes three beta-subunit genes,SIP1, SIP2 and GAL83.; Function: the yeast SNF1 complex is switched on by glucose starvation, and its targets include transcription factors that repress transcription of genes required for catabolism of alternative carbon sources.; Localization: Green fluorescent protein fusions to Gal83, Sip1, and Sip2 show different patterns of localization to the nucleus, vacuole, and/or cytoplasm.; Phenotype: the sip1Delta sip2Delta gal83Delta strain is unable to derepress invertase, grows poorly on alternative carbon sources and fails to direct the phosphorylation of the Mig1 and Sip4 proteins in vivo.; Remark: SPM2 and YGL208W are alternative names for SIP2.; Title: strong similarity to protein Sip2 -Saccharomyces cerevisiae; See PMID 10990457; See PMID 11331606
An15g00920	Function: Ttp1 participates in the cellular event of glycoprotein glycosylation essential for growth and morphogenesis, in parallel with the pathways involving Mpk1 MAP kinase and calcineurin.; Golgi; Phenotype: mnn2 mutants are defective in the addition of the first -1,2-linked mannose as it has no branches on the backbone.; Remark: TTP1 (type II membrane protein) and YBR015C are alternative names for MNN2.; Title: similarity to mannosyltransferases Mnn2 -Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928
An15g00930	Function: abc1p has a dual function: overexpression of abc1p in S. cerevisiae suppresses a cytochrome b mRNA translation defect and the protein is essential for the electron transfer in the bc1 complex.; Function: it is possible that abc1 is involved in the correct folding and/or assembly of cytochrome b and that this folding occurs during the translation process.; Phenotype: the inactivation of abc1 in S. cerevisiae leads to a respiratory deficiency suggesting a block in the bc1 segment of the respiratory chain.; Remark: YGL119w is an alternative name for ABC1.; Similarity: abc1 of S. cerevisiae belongs to the abc1 family.; Similarity: shows also weak similarity to ABC transporters.; Title: strong similarity to chaperone for ubiquinol-cytochrome c reductase Abc1 - Saccharomyces cerevisiae; See PMID 1648478; See PMID 9210471
An15g00940	Catalytic activity: urease catalyzes the reaction Urea + H(2)O <=> CO(2) + 2 H(3).; Function: the accessory protein ureF is proposed to modulate the activation process of urease by eliminating the binding of nickel irons to noncarbamylated protein.; Title: similarity to urease accessory protein ureF -Actinobacillus pleuropneumoniae; See PMID 9353010
An15g00950	Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: strong similarity to hypothetical membrane protein YDL074c - Saccharomyces cerevisiae [truncated ORF]
An15g00960	Complex: Tfc5p (chain B') in S. cerevisiae forms part of TFIIIB, composed of B', Brf, and TBP.; Function: TFIIIB in S. cerevisiae binds autonomously to the SNR6 (U6 snRNA) promoter.; Function: Tfc5p in S. cerevisiae is involved in the initiation of the transcription of type III genes by RNA polymerase III.; Function: Tfc5p in S. cerevisiae is required for assembly of the TFIIIB-TFIIIC-DNA complex.; Remark: the systematic name of TFC5 in S. cerevisiae is YNL039w.; Title: strong similarity to transcription initiation factor IIIB chain B Tfc5 - Saccharomyces cerevisiae; nucleus; See PMID 10384303; See PMID 7568218; See PMID 8617241; See PMID 9585500
An15g00970	Similarity: shows strong similarity to the protein patent database entry GENSEQPROT:W74726; Title: strong similarity to secreted protein fg949_3 from patent WO9846757-A2 - Homo sapiens; extracellular/secretion proteins
An15g00980	Complex: MMM1 of N. crassa probably forms part of an oligomeric protein complex.; Function: MMM1 in N. crassa is required for normal mitochondrial morphology independently of the major cytoskeletal system used for mitochondrial transport.; Localization: in N. crassa the insertion of MMM1 into the mitochondrial outer membrane is dependent on a mitochondrial surface receptor.; Localization: the N-terminus of MMM1 in N. crassa faces the mitochiondrial intermembrane space and the C-terminus faces the cytoplasm.; Phenotype: mmm1 mutants of N. crassa are female sterile.; Phenotype: mmm1 mutants of N. crassa exhibit abnormal giant mitochondria and abberrant mitochondria distribution.; Title: strong similarity to maintaining mitochondrial morphology protein MMM1 - Neurospora crassa; localisation:mitochondrion; See PMID 10982393
An15g00990	Catalytic activity: masB enzyme E2 (containing Ni2+) of K. oxytoca catalyzes the 1,3-oxygenlytic reaction of the aci-reductone intermediate to yield CO, formate, and methylthiopropionic acid.; Catalytic activity: masB enzyme E2' (containing Fe2+) of K. oxytoca catalyzes the 1,2-oxygenlytic reaction of the aci-reductone intermediate to yield formate and methylthio-alpha-ketobutyric acid, the alpha-ketoacid precursor of methionine.; Function: masB of K. oxytoca encodes a protein with two different 5-methylthio-3-oxo-1-penten-1,2-diol dioxygenase activities E2 or E2' in the presence of Ni2+ or Fe2+ respectively.; Pathway: the masB-encoded enzymes E-2 and E-2' in K. oxytoca catalyze different oxidation reactions of an aci-reductone intermediate in the methionine salvage pathway.; Remark: in the cited literature K. oxytoca is designated a derivative of K. pneumoniae.; Remark: the masB-encoded enzymes E-2 and E-2' of K. oxytoca are interconvertable.; Similarity: also shows similarity to the EST z3a11a1. f1 from A. nidulans (EMBLEST:AI213520).; Title: similarity to methionine salvage pathway enzyme E-2/E-2 masB - Klebsiella oxytoca; See PMID 9880484
An15g01000	Complex: Mto1p of S. cerevisiae probably forms a heterodimeric complex with Mss1p.; Function: MTO1 of S. cerevisiae is involved in the regulation of the processing of mitochondrial COX1 pre-mRNA for subunit 1 of cytochrome oxidase.; Function: gidA of bacteria is involved in the regulation of DNA replication.; Phenotype: mto1 mutants of S. cerevisiae in a paromomycin-resistant background (due to a point mutation in the mitochondrial 15S rRNA) show reduced respiratory competence.; Remark: the systematic gene name of MTO1 in S. cerevisiae is YGL236c.; Similarity: also shows strong similarity to the glucose inhibited division protein gidA of diverse bacteria.; Title: strong similarity to mitochondrial translation optimization protein Mto1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9774408
An15g01020	Catalytic activity: Crd1p of S. cerevisiae catalyzes the transfer of a phosphatidyl moiety from CDP-diacylglycerol to phosphatidylglycerol in the presence of Mg2+.; Complex: Crd1p of S. cerevisiae forms an oligomeric complex whose biogenesis and/or activity is influenced by the assembly of cytochrome oxidase.; Localization: Crd1p of S. cerevisiae is located to the inner mitochondrial membrane.; Pathway: Crd1p of S. cerevisiae catalyzes the final step of the cardiolipin biosynthesis.; Phenotype: crd1- mutants of S. cerevisiae are not viable under elevated-temperature conditions.; Phenotype: in crd1- mutants of S. cerevisiae the efficiency of oxidative phosphorylation is decreased.; Remark: the systematic name of CRD1 (CLS1) of S. cerevisiae is YDL142c.; Similarity: belongs to the CDP-alcohol phosphatidyltransferase family.; Title: strong similarity to cardiolipin synthase Crd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10769171; See PMID 9370334; See PMID 9442089; See PMID 9462830; See PMID 9614098
An15g01050	Title: weak similarity to hypothetical protein R03H4.2 - Caenorhabditis elegans
An15g01060	Similarity: also shows weak homology to the C-terminal part of the small nuclear ribonucleoprotein SIK1 of S. cerevisiae involved in 35S rRNA primary transcript processing.; Similarity: also shows weak homology to the N-terminal part of cGMP-gated ion channel proteins from diverse mammalian species.; Similarity: the homology is restricted to a small centrally located region of At2g28290 from A. thaliana.; Title: weak similarity to hypothetical SNF2 subfamily global transcription activator At2g28290 -Arabidopsis thaliana
An15g01110	Remark: the gti1 (gluconate transport inducer 1) mutation in S. pombe leads to a 10-fold decrease in the onset of gluconate uptake in response to starvation.; Title: similarity to gluconate transport-inducing protein gti1p - Schizosaccharomyces pombe; See PMID 9372449
An15g01130	Function: the ATP-binding cassette transporter bfr1 from Schizosaccharomyces pombe confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. It could serve as an efflux pump of various antibiotics.; Remark: alternate names for S. pombe bfr1 ABC-transporter: SPBC18B5. 01C or hba2.; Similarity: the ORF encoded protein shows also strong similarity to the weak acid pump protein Pdr12 from S. cerevisiae described in patent WO9951746-A1.; Title: strong similarity to brefeldin A resistance protein bfr1p - Schizosaccharomyces pombe; See PMID 7646493; See PMID 7883711
An15g01140	Similarity: the ORF encoded protein shows significant similarity to a group of hypothetical proteins,which are homologs to the Caenorhabditis elegans hypothetical protein F52C12. 1.; Title: similarity to tyrosine-DNA phosphodiesterase TDP1 from patent WO200125407-A2 - Homo sapiens
An15g01155	Title: strong similarity to hypothetical protein CAC18246.1 - Neurospora crassa
An15g01160	Function: the Dhr1p from S. cerevisiae is a probable ATP-binding RNA helicase, which is required for 18S rRNA synthesis. It associates with the U3 snoRNP and may play a role in restructuring of the pre-rRNA. Depletion of Dhr1 inhibited processing steps that require base pairing of U3 to the 5' end of the 18S rRNA.; Remark: alternate names for S. cerevisiae Dhr1: Ecm16 or YMR128W.; Title: strong similarity to DEAH-box RNA helicase Dhr1 - Saccharomyces cerevisiae; nucleus; See PMID 10982841
An15g01170	Complex: the human SRm160 and the related protein SRm300 form a complex that is required for the splicing of specific pre-mRNAs.; Function: the SRm160/300 complex associates with splicing complexes and promotes splicing through interactions with SR family proteins.; Remark: SRm300= 300-kD nuclear matrix antigen.; Title: similarity to splicing coactivator subunit SRM300 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10668804
An15g01180	Function: the Pumilio protein from D. melanogaster is involved in translational regulation of hunchback (hb) mRNA, which is essential for posterior patterning of the Drosophila embryo. This regulation is mediated by sequences in the 3'-untranslated region of hb mRNA (the Nanos response elements or NREs.). Nonos and Pumilio are the two important trans-acting factors.; Similarity: the ORF encoded protein belongs to the Pumilio/Mpt5 family. It also shows strong similarity to the human protein of the Pumilio/Mpt5 family described in patent WO9824815-A1.; Title: strong similarity to RNA binding protein Pumilio Pum - Drosophila melanogaster; cytoplasm; See PMID 10541556; See PMID 10662662
An15g01190	Remark: N-terminally truncated ORF due to the end of contig.; Title: weak similarity to hypothetical protein YNL224 - Saccharomyces cerevisiae [truncated ORF]
An15g01200	Title: weak similarity to hypothetical protein PA3340 - Pseudomonas aeruginosa
An15g01210	Title: weak similarity to phospholipid scramblase 3 - Homo sapiens
An15g01230	Function: gigas mutant cells are enlarged and repeat S phase without entering M phase, but differentiate normally to produce adult structures.; Similarity: the predicted A. niger protein shows similarity to the gigas protein gig of D. melanogaster, to human tuberous sclerosis 2 protein (TSC2) and related proteins. the best match is to the conserved hypothetical protein SPAC630. 13c of S. pombe.; Title: similarity to gigas protein gig - Drosophila melanogaster; See PMID 10052455
An15g01240	Title: strong similarity to protein required for accurate mitotic chromosome segregation Cse1 -Saccharomyces cerevisiae; See PMID 8336709; See PMID 9774694
An15g01250	Similarity: PrfB belongs to the prokaryotic and mitochondrial release factors family.; Title: similarity to peptide chain release factor 2 PrfB - Streptomyces coelicolor; See PMID 7545157
An15g01260	Title: weak similarity to hypothetical protein C24A8.3 - Caenorhabditis elegans
An15g01270	Function: the S. cerevisiae PET100 protein is required for the biogenesis of the cytochrome c oxidase. It is probably involved in its assembly into the active holoenzyme.; Remark: alternate name for S. cerevisiae Pet100: YDR079W.; Title: similarity to assembly factor of cytochrome c oxidase Pet100 - Saccharomyces cerevisiae; See PMID 8702496
An15g01280	Function: A bacterially expressed form of the S. cerevisiae Eci1 protein catalyzed the isomerization of 3-cis-octenoy-CoA to 2-trans-octenoyl-CoA.; Remark: A S. cerevisiae mutant devoid of Eci1 was unable to grow on media containing unsaturated fatty acids such as oleic acid but was proficient for growth when a saturated fatty acid such as palmitic acid was the sole carbon source.; Remark: alternate name for S. cerevisiae Eci1: YLR284c.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046; See PMID 9837886
An15g01290	Remark: the human D123 protein is identical to the protein described in patent JP08092288-A and to the human HT-1080 protein.; Title: strong similarity to protein D123 - Homo sapiens; See PMID 8601400
An15g01300	Title: weak similarity to suppressor of telomeric repression-7 STR7 from patent WO9612811-A2 - Saccharomyces cerevisiae
An15g01310	Function: the MOZ protein represents a chromatin-associated acetyltransferase.; Remark: the human MOZ protein participates in a T(8; 16)(P11;P13) chromosomal translocation that produces a MOZ-CBP chimaera observed in the M4/M5 subtype of acute myeloid leukemia.; Title: similarity to monocytic leukemia zinc finger protein MOZ - Homo sapiens; See PMID 10839822; See PMID 11243405
An15g01320	Title: strong similarity to hypothetical protein pi070 - Schizosaccharomyces pombe
An15g01330	Similarity: the ORF encoded protein shows also strong similarity to the Chlamydia pneumoniae protein of unknown function described in patent WO9927105-A2.; Title: strong similarity to hypothetical conserved protein aq_1575 - Aquifex aeolicus
An15g01340	Function: Mis6 from S. pombe is located in the inner regions of the centromeres and is essential for sister chromatid segregation during the G1/S phase following mitosis.; Similarity: the ORF encoded protein shows strong similarity to the rat protein of unknown function LRPR1.; Title: similarity to inner centromere protein mis6p - Schizosaccharomyces pombe; nucleus; See PMID 9230309; See PMID 10766735; See PMID 10900382
An15g01350	Similarity: the ORF encoded protein shows similarity to the functional unknown human secreted protein encoded by gene 55 of the patent WO9931117-A1.; Title: strong similarity to hypothetical cleft lip and palate transmembrane protein 1 CLPTM1 - Homo sapiens; See PMID 9828125
An15g01360	Catalytic activity: retinol + NADP(+) <=> retinal + NADPH.; Function: the human retinol dehydrogenase (prRDH) catalyzes the reduction of all-trans-retinal to all-trans-retinol within the photoreceptor outer segment.; Title: similarity to all-trans-retinol dehydrogenase from photoreceptor outer segments prRDH - Homo sapiens; See PMID 10753906
An15g01370	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein CAD70933.1 - Neurospora crassa
An15g01380	Function: Sec22 from S. cerevisiae is a v-SNARE involved in the visicle transport between the endoplasmic reticulum and Golgi complex.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Remark: alternate names for S. cerevisiae Sec22: Sly2, Tsl26, YLR268W.; Similarity: S. cerevisiae Sec22 belongs to the synaptobrevin family.; Title: strong similarity to Synaptobrevin homolog v-SNARE Sec22 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9202032; See PMID 11001058
An15g01390	Function: S. cerevisiae Iki1 is essential for the intracellular killing process of pGKL killer toxin. The S. cerevisiae iki mutants show an insensitive phenotype to the pGKL killer toxin.; Remark: an alternate name for S. cerevisiae Iki1 is YHR187W.; Title: strong similarity to hypothetical killer toxin insensitive protein 1 Iki1 - Saccharomyces cerevisiae; See PMID 9145530
An15g01400	Similarity: the ORF encoded protein is very repetitive. It has arginine-rich regions and shows similarities to proteins which may be able to bind RNA. The ORF DNA sequence is similar to the E. nidulans EST p0h09a1. r1.; Title: similarity to U1 snRNP 70K protein -Arabidopsis thaliana; See PMID 8776903
An15g01410	Title: strong similarity to protein fragment SEQ ID NO:57973 from patent EP1033405-A2 - Arabidopsis thaliana
An15g01420	Function: S. cerevisiae Cwh41 cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.; Pathway: S. cerevisiae Cwh41 is the first enzyme in the N-linked oligosaccharide processing pathway.; Remark: alternate names for S. cerevisiae Cwh41: Gls1, YGL027C.; Title: strong similarity to glucosidase I Cwh41 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9363442; See PMID 9763440; See PMID 9878780
An15g01430	Title: similarity to protein fragment SEQ ID NO:47464 from patent EP1033405-A2 - Arabidopsis thaliana
An15g01440	Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST d5b12a1. f1.; Title: weak similarity to hypothetical protein SPBC27B12.05 - Schizosaccharomyces pombe
An15g01450	Complex: In yeast two-hybrid assays the Drosophila protein ARI-1 interacts with a novel ubiquitin-conjugating enzyme UbcD10.; Title: similarity to ariadne-1 protein ari -Drosophila melanogaster; See PMID 10880484
An15g01460	Remark: S. cerevisiae cwh8/cax4 mutants show an anomalous cell wall, the mutation also affects the actin organization.; Remark: alternate names for S. cerevisiae Cwh8: Cax4 or YGR036c.; Similarity: the S. cerevisiae Cwh8 (Cax4) protein contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases,including lipid phosphatases and a protein phosphatase.; Title: strong similarity to Cwh8 - Saccharomyces cerevisiae; See PMID 9725829; See PMID 10024662
An15g01470	Title: similarity to secreted protein #5 from patent WO200107459-A1 - Homo sapiens
An15g01480	Localization: SmMAK16, the Schistosoma mansoni homologue of the S. cerevisiae Mak16 protein is localized exclusively in nucleoli (Pubmed 10838225).; Remark: S. cerevisiae mak16 mutants show a decreased amount of free 60S ribosomal subunits. Conditional mutants arrest at G(sub)1, are deficient in maintenance of killer M1 double-stranded RNA.; Remark: alternate name for S. cerevisiae Mak16: YAL025C.; Title: strong similarity to Mak16 - Saccharomyces cerevisiae; nucleus; See PMID 7739558; See PMID 3045810
An15g01490	Title: weak similarity to hypothetical conserved protein encoded by 9G6.060 - Araneus diadematus
An15g01500	Remark: Saccharomyces pastorianus=Saccharomyces carlsbergensis.; Title: strong similarity to fructose symporter Fsy1 - Saccharomyces pastorianus; plasma membrane; See PMID 10986274
An15g01510	Function: the S. cerevisiae Drs2 protein is a magnesium dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium . It is involved in the late Golgi function and a possible link between membrane asymmetry and clathrin function at the Golgi complex (Pubmed 10601336). It seems to be less important for aminophospholipid translocation as earlier published (compare Pubmed 8633245 with 9852106;10429211).; Golgi; Localization: Subcellular fractionation and immunofluorescence analysis indicate that Drs2 localizes to late Golgi membranes containing Kex2.; Remark: alternate names for S. cerevisiae Drs2: Fun38, Swa8 or YAL026C.; Title: strong similarity to P-type ATPase Drs2 -Saccharomyces cerevisiae; See PMID 10601336
An15g01520	Remark: Sec16p S. cerevisiae engages in multiple protein-protein interactions both on the ER membrane and as part of the coat of a completed vesicle. Some Sec16p is localized to the ER by immunofluorescence microscopy. Membrane-associated Sec16p is incorporated into transport vesicles derived from the ER that are formed in an in vitro vesicle budding reaction.; Title: strong similarity to multidomain vesicle coat protein Sec16 - Saccharomyces cerevisiae; See PMID 7593161
An15g01530	Complex: Hus1 participates in a protein complex with Rad9 and Rad1.; Localization: Hus1 is a nuclear protein and that this localization depends on Rad17.; Remark: Hus1 fission yeast protein levels are not affected by S-phase arrest, and are not altered by mutations in other checkpoint genes, suggesting that Hus1 is not regulated at the transcriptional or translational levels.; Similarity: the predicted A. niger protein shows strong similarity to mitotic and DNA damage checkpoint protein Hus1 of S. pombe and homologous proteins from diverse eucaryotic species.; Title: strong similarity to mitotic and DNA damage checkpoint protein hus1p - Schizosaccharomyces pombe; See PMID 9180692; See PMID 10648611
An15g01550	Title: similarity to hypothetical conserved protein B11N2.10 - Neurospora crassa
An15g01560	Remark: Gyp7p S. cerevisiae was able to most effectively accelerate the intrinsic GTPase activity of Ypt7p. It was also active, but to a lesser extent, on Ypt31p, Ypt32p and Ypt1p. Ypt6p, Sec4p and the human H-Ras protein did not serve as substrates.; Title: strong similarity to GTPase activating protein Gyp7 - Saccharomyces cerevisiae; See PMID 10091609; See PMID 10508155
An15g01580	Remark: weak similarity to H. pylori cell envelope protein 05ae20220orf32 patent WO9640893-A1.; Title: weak similarity to cell envelope protein 05ae20220orf32 from patent WO9640893-A1 - Helicobacter pylori
An15g01590	Remark: Growth of Alcaligenes sp. strain O-1 with 2-aminobenzenesulfonate (ABS; orthanilate) as sole source of carbon and energy requires expression of the soluble,multicomponent 2-aminobenzenesulfonate 2,3-dioxygenase system (deaminating) (ABSDOS).; Similarity: belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.; Title: similarity to 2-aminobenzenesulfonate dioxygenase large subunit absA - Alcaligenes sp.; putative frameshift; See PMID 10589735
An15g01600	Title: similarity to hypothetical peroxisomal organisation and biogenesis protein SPAC3G6.05 -Schizosaccharomyces pombe
An15g01620	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An15g01640	Title: weak similarity to kinesin light chain KLC -Plectonema boryanum
An15g01650	Function: the TetH from Pasteurella multocida gives resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/h+ antiporter.; Similarity: belongs to the prokaryotic drug resistance translocase family.; Title: similarity to tetracycline resistance protein TetH - Pasteurella multocida; See PMID 8109938
An15g01670	Remark: SRP101 from Yarrowia lipolytica is presumably involved in protein targeting to and translocation across the endoplasmic reticulum.; Title: strong similarity to signal sequence receptor alpha subunit SRP101 - Yarrowia lipolytica; See PMID 10992287
An15g01680	Remark: strong similarity to human signal peptide-containing protein (SIGP) (clone ID 2328134) patent WO9933981-A2.; Title: strong similarity to signal peptide-containing protein SIGP from patent WO9933981-A2 -Homo sapiens
An15g01690	Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to EST BE758857 A. niger.; Remark: there are to L14 proteins in yeast and there are part of the large ribosomal (60s) subunit.; Similarity: belongs to the L14e family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L14.a - Saccharomyces cerevisiae; cytoplasm; See PMID 9559554; See PMID 10542411; See PMID 10690410
An15g01700	Remark: NAC (nascent polypeptide-associated complex) is an alpha/beta heterodimeric complex binding the newly synthesized polypeptide chains as they emerge from the ribosome.; Remark: a splice site was detected upstream of the START codon.; Remark: differential splicing converts alphaNAC from mouse into a tissue-specific DNA-binding activator and suggest that this regulation may be an important event in the proper control of gene expression during myogenic differentiation.; Title: strong similarity to nascent polypeptide-associated complex alpha chain alpha-NAC - Mus musculus; See PMID 8698236
An15g01710	Catalytic activity: ATP + H2O = ADP + orthophosphate.; Function: ATP7 from Kluyveromyces lactis is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial ATPase complex.; Pathway: oxidative phosphorylation; photosynthesis; ATP synthase.; Remark: the subunit D is nuclear encoded.; Similarity: to the H+-transporting ATP synthases chain d.; Title: strong similarity to F1Fo-ATP synthase subunit 7 ATP7 - Kluyveromyces lactis; See PMID 9790576
An15g01720	Title: similarity to hypothetical protein encoded by An03g03510 - Aspergillus niger
An15g01740	Catalytic activity: succinate semialdehyde + NAD+ or NADP+ + H2O = succinate + NADH or NADPH.; Pathway: 4-aminobutyrate (GABA) degradation pathway.; Similarity: belongs to the aldehyde dehydrogenase family.; Title: similarity to succinate-semialdehyde dehydrogenase NAD(P)+ gabD - Escherichia coli; See PMID 8297211; See PMID 2254272
An15g01750	Remark: the ORF shows C-terminal similarity to the apurinic/apyrimidinic endonuclease III family.; Title: similarity to hypothetical protein B2J23.160 - Neurospora crassa
An15g01760	Catalytic activity: 5-phospho-beta-D-ribosylamine + pyrophosphate + L-Glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.; Pathway: purine metabolism; glutamate metabolism.; Remark: also strong similarity to Sequence 3 from Ashbya possypii Patent EP0927761.; Remark: northern blots demonstrate that ADE4 expression in yeast is transcriptionally regulated.; Similarity: belongs to the amidophosphoribosyltransferases.; Title: strong similarity to amidophosphoribosyltransferase Ade4 - Saccharomyces cerevisiae; See PMID 6376509
An15g01770	Catalytic activity: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA 5-methylcytosine.; Remark: the disruption of masc1 has no effect on viability or methylation maintenance but prevents the de novo methylation of DNA repeats, which takes place after fertilization, through the methylation induced premeiotically (MIP) process.; Similarity: belongs to the site-specific DNA methylase dcm.; Title: strong similarity to C5-DNA methyltransferase Masc1 - Ascobolus immersus; See PMID 9346245
An15g01780	Catalytic activity: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.; Pathway: lysine biosynthesis.; Remark: the prpBCDE genes constitute an operon in Salmonella typhimurium which encodes catabolic functions required for propionate catabolism.; Title: strong similarity to 2-methylcitrate dehydratase PrpD - Salmonella typhimurium; See PMID 9006051; See PMID 10482501
An15g01790	Remark: the DAL5 gene product is highly hydrophobic. DAL5 gene, encoding a necessary component of the allantoate transport system, is constitutively expressed in S. cerevisiae.; Similarity: member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804
An15g01800	Remark: strong similarity to corynebacterium glutamicum gene sequence 211 from Patent WO0100842.; Similarity: to metal-dependent amidohydrolases/aminoacylases.; Title: strong similarity to protein from patent WO0100842-A - Corynebacterium glutamicum
An15g01810	Title: strong similarity to hypothetical protein encoded by An01g11620 - Aspergillus niger
An15g01820	Title: weak similarity to lung Kruppel-like factor LKLF - Mus musculus
An15g01830	Remark: the main function of the ATPases is the adaptation to stress conditions.; Similarity: belongs to the cation transport ATPases.; Title: strong similarity to sodium P-type ATPase ena-1 - Neurospora crassa; See PMID 10712689
An15g01840	Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to Secoisolariciresinol dehydrogenase protein clone SMDEHY511 patent WO9955846-A1.; Remark: the patant protein is involved in lignan biosynthetic pathway.; Similarity: belongs to the dehydrogenases with different specificities.; Title: strong similarity to secoisolariciresinol dehydrogenase SMDEHY511 from patent WO9955846-A1 -Forsythia intermedia; See PMID 10629170
An15g01850	Catalytic activity: ATP + L-Glutamate + NH3 = ADP + Orthophosphate + L-Glutamine.; Pathway: glutamate metabolism; peptideglycan biosynthesis; nitrogen metabolism.; Remark: Glutamine synthetase (GS), an essential enzyme in ammonia assimilation and glutamine biosynthesis,has three distinctive types: GSI, GSII and GSIII. Genes for GSI have been found only in bacteria (eubacteria) and archaea (archaebacteria), while GSII genes only occur in eukaryotes and a few soil-dwelling bacteria.; Similarity: belongs to the glutamate-ammonia ligase.; Title: strong similarity to glutamine synthase glnA - Pyrococcus sp; See PMID 7916055; See PMID 9172372
An15g01860	Catalytic activity: L-malate + CoA = acetyl-CoA + H2O + glyoxylate.; Pathway: pyruvate metabolism; glyoxylate and dicarboxylate metabolism.; Remark: in fungi, the malate synthase proteins are located in glyoxysomes and the deduced acuE and acu-9 proteins both contain a C-terminal S-K-L sequence, which has been implicated in transport into peroxisomes.; Similarity: belongs to the malate synthase family.; Title: strong similarity to malate synthase acuE -Aspergillus nidulans
An15g01870	Title: strong similarity to hypothetical protein encoded by An12g05110 - Aspergillus niger
An15g01880	Title: strong similarity to hypothetical IgE-binding protein - Aspergillus fumigatus
An15g01890	Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidase plays a morphogenetic role in the parasitic cycle of C. immitis.; Similarity: belongs to the beta-glucosidase-related glycosidases.; Title: strong similarity to beta-glucosidase precursor bgl2 - Coccidioides immitis; See PMID 11254576
An15g01900	Remark: disruption of the CTR locus completely abolished the choline transport activity, indicating that the CTR product is the sole choline transporter in yeast.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 2203793
An15g01910	Function: the translational elongation factor 3 (EF-3) superfamily stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome.; Remark: the requirement for EF-3 is unique to fungi,a functional analog has not been found in prokaryotes or other eukaryotes.; Similarity: the C. albicans homolog ELF1 has homology to the ATP-binding cassette (ABC) gene family. Members of this gene family include both membrane transport proteins which confer a drug-resistance phenotype, and proteins whose functions are associated with protein translation.; Title: strong similarity to elongation-like factor ELF - Candida albicans; See PMID 9720054
An15g01920	Catalytic activity: 2-methylcitrate + CoA = propanoyl-CoA + H2O + oxaloacetate; Pathway: propanoate metabolism.; Remark: propionate is oxidized to pyruvate via the methylcitrate cycle. The key enzyme is methylcitrate synthase. A mcsA deletion strain was unable to grow on propionate. The inhibitory growth effect of propionate on glucose medium was enhanced in this strain, which led to the assumption that trapping of the available CoA as propionyl-CoA and/or the accumulating propionyl-CoA itself interferes with other biosynthetic pathways such as fatty acid and polyketide syntheses.; Similarity: belongs to the citrate (si)-synthases.; Title: strong similarity to methylcitrate synthase mcsA - Aspergillus nidulans; See PMID 10712680
An15g01930	Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An15g01940	Function: the ORF seems to be a putative isoamyl alcohol oxidase.; Similarity: strong similarity to thale cress sequence 70 from Patent WO9813478 found in TREMBL:A71637_1.; Similarity: the ORF shows similarity to several oxidoreductases.; Title: strong similarity to antifungal protein from patent WO9813478-A - Arabidopsis thaliana
An15g01950	Remark: strong similarity to A. crisogenum Cephalosporin C patent JP06038763-A.; Similarity: belongs to the acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.; Title: strong similarity to Cephalosporin C from patent JP06038763-A - Acremonium chrysogenum; See PMID 11405634
An15g01960	Remark: Fructosyl amino acid oxidase (FAOD), is active toward model compounds of the glycated proteins in blood, N epsilon-fructosyl N sigma-Z-lysine and N-fructosyl valine.; Title: strong similarity to fructosyl amino acid oxidase faoP - Penicillium janthinellum; See PMID 9022674
An15g01970	Remark: in the CNS Brn-3. 2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes.; Title: similarity to unassigned homeobox protein Brn-3.2 - Mus sp.; See PMID 7904822; See PMID 8162704
An15g01980	Catalytic activity: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2.; Pathway: biotin metabolism.; Remark: belongs to a putative biotin synthesis cluster.; Remark: strong similarity to hlamydia pneumoniae transmembrane protein sequence patent WO9927105-A2.; Similarity: belongs to the 7-keto-8-aminopelargonate synthetase and related enzymes.; Title: strong similarity to 8-amino-7-oxononanoate synthase from patent WO9927105-A2 - Chlamydia pneumoniae
An15g01990	Catalytic activity: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.; Pathway: biotin metabolism.; Remark: similarity to metabolic pathway protein patent WO0100843-A/639 from Corynebacterium glutamicum found in TREMBL:AX064357_1.; Remark: the predicted ORF seems N-terminal approximately 250 amino acids to long.; Remark: this ORF is probable a adenosylmethionine-8-amino-7-oxononanoate aminotransferase-like protein and belongs to a putative biotin synthesis cluster.; Similarity: the ORF shows strong similarity to several putative adenosylmethionine--8-amino-7-oxononanoate transaminases.; Title: strong similarity to biotin synthesis enzyme from patent WO0100843-A - Corynebacterium glutamicum
An15g02000	Catalytic activity: dethiobiotin + sulfur = biotin.; Pathway: biotin metabolism.; Remark: biotin synthase catalyzes the insertion of a sulfur atom between two carbon atoms of dethiobiotin to form biotin in the last step of the biotin biosynthesis pathway.; Similarity: belongs to the biotin and lipoic acid synthetases family.; Title: strong similarity to biotin synthase Bio2 -Saccharomyces cerevisiae; See PMID 8117110
An15g02040	Remark: the N-terminus of the ORF is identical to EST SEQ ID NO:4121 from patent WO200056762-A2.; Title: strong similarity to EST an_3318 -Aspergillus niger
An15g02050	Title: similarity to hypothetical protein encoded by An04g09900 - Aspergillus niger
An15g02070	Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Function: the salicylate 1-monooxygenase NahG from Pseudomonas putida strain PpG7 is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181; See PMID 2363715
An15g02080	Remark: the regulator An1000 is involved in the gene expression regulation of FLO11, lovF, lovE or acvA.; Remark: the similarity of the ORF encoded protein to blastp matches is restricted to the Fungal Zn(2)-Cys(6) binuclear cluster.; Title: strong similarity to lovF gene expression regulator An1000 from patent WO200257456-A2 - Unclassified organism; nucleus
An15g02090	Title: strong similarity to hypothetical protein EAA77948.1 - Gibberella zeae
An15g02110	Catalytic activity: Penicillin + H2O = a Carboxylate + 6-Aminopenicillanate.; Remark: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Title: similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum
An15g02120	Phenotype: A. nidulans cells lacking the tcsA gene are unable to produce conidia on standard Aspergillus growth media.; Remark: the ORF encoded protein shows similarity to many hypothetical two component histidin kinases and contains a corresponding PFAM domain.; Remark: the tscA protein has not been described.; Title: strong similarity to histidine kinase tcsA -Aspergillus nidulans; See PMID 10905426
An15g02130	Function: lovF from A. terreus specifies formation of 2-methylbutyrate.; Remark: lovF is synonymous to lovastatin diketide synthase LDKS.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994; See PMID 10381407
An15g02140	Similarity: the similarity of the predicted A. niger protein is to the N-termnal region of S. pombe dfr1, while the conserved dihydrofolate reductase domain is at the C-terminus of dfr1.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538
An15g02150	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: the A. niger protein is 300 amino acids shorter than PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An15g02160	Title: similarity to hypothetical protein BAC45498.1 - Bradyrhizobium japonicum
An15g02180	Catalytic activity: salicylate hydroxylases convert Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Function: NahW of P. stutzeri exhibits a broad substrate specificities and metabolize salicylate,methylsalicylates, and chlorosalicylates.; Function: NahW of P. stutzeri is involved in naphthalene and salicylate metabolism.; Remark: the A. niger protein also shows similarity to 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens strain TN5 from patent JP09121864-A.; Remark: the similarity is restricted to small region of the proteins.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An15g02190	Function: the bmr3 transporter of B. subtilis functions as a multidrug transporter: it mediates resistance to puromycin, tosufloxacin, and norfloxacin.; Induction: expression of bmr3 is dependent on the growth phase of B. subtilis.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234
An15g02200	Catalytic activity: AOD1 of C. boidinii converts primary alcohol + O2 = aldehyde + H2O2.; Function: the AOD1 protein of C. boidinii is the first key enzyme for methanol metabolism.; Remark: AOD1 of C. boidinii belongs to the oxidoreductases family.; Similarity: the A. niger EST ID NO:4251 in PATENTDNA:AAF11728 overlaps with the ORF at the ORF's extreme C-terminus (patent WO200056762-A2).; Title: strong similarity to alcohol oxidase AOD1 -Candida boidinii; See PMID 1587486
An15g02210	Function: the triacylglycerol of C. rugosa mediates the breakdown of lipids.; Remark: C. rugosa is also named C. cylindricacea.; Remark: the triacylglycerol lipase of C. rugosa belongs to the type-B carboxylesterase/lipase family.; Similarity: the ORF shows also strong similarity to the cholesterol esterase of C. rugosa.; Title: strong similarity to extracellular triacylglycerol lipase Lip1 - Candida rugosa; See PMID 8142346; See PMID 8509417; See PMID 11457462; See PMID 1610906
An15g02230	Remark: unusual exon/intron structure for A. niger and short length (122 amino acids).
An15g02250	Remark: the ORF is short in length
An15g02280	Function: the WOX1 protein of M. musculus is a mitochondrial apoptogenic protein.; Induction: the WOX1 protein of M. musculus downregulates the apoptosis inhibitors Bcl-2 and Bcl-x(L) and upregulates pro-apoptotic p53.; Induction: the WOX1 protein of M. musculus is induced by hyaluronidase.; Localization: WOX1 protein of M. musculus is mainly located in the mitochondria.; Remark: WOX1 of M. musculus belongs to the short-chain dehydrogenases/reductases (sdr) family.; Title: similarity to WW domain-containing oxidoreductase WOX1 - Mus musculus; See PMID 11058590
An15g02290	Function: mepB of A. fumigatus is probably involved in the intracellular degradation of small peptides.; Phenotype: gene disruption of the mepB gene of A. fumigatus did not reveal any detectable phenotype.; Remark: mepB of A. fumigatus is a cytosolic zinc metalloproteinase of the thimet oligopeptidase family (M3).; Similarity: the ORF shows also strong similarity to S. cerevisiae saccharolysin and to thimet oligopeptidases of various species also involved in cytoplasmic peptide degradation.; Similarity: the extreme C-terminus of the ORF overlaps with the 5' genomic sequence preceding the A. niger abf B gene (see adjacent ORF An15g02300) in EMBL:ANABFB and EMBL:ANABFB1.; Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; cytoplasm; See PMID 9245813
An15g02300	Catalytic activity: abfB of A. niger is involved in the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.; Function: abfB of A. niger is involved in degradation of the cell wall polysaccharide L-arabinan.; Gene-ID: abfB;abf2;awabfB;exoB; Similarity: abfB of A. niger belongs to family 54 of glycosyl hydrolases.; Similarity: the ORF differs from the abfB protein from patent EP506190-A in a single amino acid (G19A).; Similarity: the ORF is nearly identical to the abfB protein from A. niger in PIR:S39113: they differ in a single amino acid (D465E).; See PMID 8299175
An15g02310	Similarity: the ORF overlaps with the A. niger sequence from patent EP506190-A; the overlapping patent sequence is the 3' untranslated sequence of the abfB gene,which is encoded on the neighbouring ORF (An15g02300).
An15g02320	Function: the ATP11 protein of S. cerevisiae (together with ATP12) is essential for the expression of the functional F1-ATPase in acting as a chaperone (it binds the ATPase's beta-subunit).; Localization: the ATP11 protein of S. cerevisiae is found in mitochondria (immunochemical evidence).; Phenotype: ATP11 gene mutants of S. cerevisiae had 10% or less of wild-type ATPase activity.; Remark: alternate names for ATP11 of S. cerevisiae are protein N0357 and YNL315c.; Title: strong similarity to chaperone protein Atp11 - Saccharomyces cerevisiae; See PMID 10681564; See PMID 1532796
An15g02330	Remark: unusual intron/exon structure for A. niger.
An15g02340	Pathway: arg1 of S. cerevisiae in active in the urea cycle, where it is involved in the penultimate step of the arginine biosynthetic pathway.; Phenotype: systematic deletion of the arg1 gene of S. cerevisiae produced a viable phenotype.; Regulation: transcription of arg1 protein of S. cerevisiae is not affected by the presence of arginine in the growth medium whereas enzyme activity is.; Remark: Alternate names for arg1 of S. cerevisiae are arg10, citrulline-aspartate ligase, protein O1228, and YOL058w.; Remark: arg1 of S. cerevisiae is a member of the argininosuccinate synthase family.; Title: strong similarity to argininosuccinate synthase Arg1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2897249
An15g02350	Remark: the ORF has some gaps (one over 30 amino acids) if aligned with the N. crassa protein.; Similarity: the ORF is serine rich and therefore shows unspecific homologies to other serine rich proteins (e. g. D. discoideum spore coat protein sp96).; Title: strong similarity to hypothetical precursor of spore coat protein sp96 - Neurospora crassa
An15g02360	Localization: acetylornithine aminotransferases localize to the mitochondrial matrix.; Pathway: acetylornithine aminotransferases catalyze the fourth step in arginine biosynthesis.; Phenotype: disruption of the arg8 gene in K. lactis resulted in strains auxotrophic for arginine.; Remark: acetylornithine aminotransferases belong to class-III of pyridoxal-phosphate-dependent aminotransferases.; Similarity: the A. niger EST an_2621 in EMBLEST:BE759720 overlaps with the ORF.; Title: strong similarity to acetylornithine aminotransferase arg8 - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9544247
An15g02370	Induction: the expression level of ccg-8 of N. crassa is influenced by circadian rhythm (it preferentially accumulates from light-night to early-morning).; Remark: the ORF shows also similarity to the transcription regulator OPI1 of S. cerevisiae and due to its relatively high serine content unspecific similarity to proteophosphoglycans.; Similarity: the ccg-8 gene of N. crassa is 199 amino acids shorter at the N-terminus than the ORF.; Title: similarity to clock-controlled gene-8 ccg-8 -Neurospora crassa; See PMID 8917550
An15g02380	Remark: the ORF is C-terminally truncated due to the contig border.; Title: strong similarity to hypothetical transmembrane protein SPAC977.11 - Schizosaccharomyces pombe [truncated ORF]
An15g02390	Catalytic activity: estradiol 17beta-dehydrogenase type 1 catalyzes the reaction Estradiol-17-beta + NAD(P)(+) <=> estrone + NAD(P)H.; Remark: the A. niger protein also shows strong similarity to many different hypothetical dehydrogenases and it contains a short chain dehydrogenase PFAM domain.; Title: similarity to estradiol 17-beta-dehydrogenase type 1 - Homo sapiens; See PMID 2779584; See PMID 3456799
An15g02400	Remark: the A. niger ORF also shows strong similarity to EST an_0173 of A. niger.; Title: similarity to hypothetical protein CG11840 -Drosophila melanogaster
An15g02410	Function: hNmrr is a nitrogen metabolic repression regulator protein.; Title: similarity to nitrogen metabolic repression regulator hNmrr from patent CN1269419-A - Homo sapiens
An15g02420	Function: eIF-2B is a guanin nucleotide releasing protein for eIF-2. eIF-2 forms a complex with GTP and mediates the binding of the methionyl initiator tRNA to the small rubosomal subunit, which then binds to the 5' cap of the mRNA and begins scanning along the mRNA.; Function: eIF-2B is required to cause GDP release so that a nex GTP molecule can bind and eIF2 can be reused.; Title: similarity to eukaryotic translation initiation factor eIF2B subunit 3 - Homo sapiens; cytoplasm; See PMID 10900014
An15g02440	Function: Gcn20p of S. cerevisiae functions together with Gcn1p in facilitating the activation of Gcn2p by uncharged tRNA on translating ribosomes.; Function: Gcn20p of S. cerevisiae is a component of a protein complex that couples the kinase activity of GCN2 to the availability of amino acids.; Remark: the A. niger ORF contains a putative sequencing error at position 28062.; Similarity: Gcn20p of S. cerevisiae is a member of ATP-binding cassette (ABC) family, eF-3 subfamily.; Title: strong similarity to positive effector of Gcn2p Gcn20 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 7621831; See PMID 9234705
An15g02450	Title: weak similarity to regulator protein Ppr1 -Saccharomyces cerevisiae
An15g02460	Phenotype: aro8 mutants cannot grow on minimal medium supplemented with tryptophane, kinurenine,phenylalanine and tyrosine.; Remark: YGL202W is the systematic name for ARO8.; Similarity: ARO8 belongs to the aminotransferase subgroup I.; Title: similarity to aromatic aminotransferase I Aro8 - Saccharomyces cerevisiae; See PMID 9491083; See PMID 9491082
An15g02470	Title: weak similarity to hypothetical variant surface glycoprotein MVAT5 homolog - Trypanosoma brucei
An15g02490	Catalytic activity: leuB of Sulfolobus sp. catalyzes the reaction 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH (the product decarboxylates to 4-methyl-2-oxopentanoate).; Pathway: leuB of Sulfolobus sp. catalyzes the third step in leucine biosynthesis.; Remark: the A. niger protein also shows strong similarity to the unpublished homo-isocitrate dehydrogenase LYS12 of S. cerevisiae that is involved in lysine biosynthesis.; Similarity: leuB of Sulfolobus sp. belongs to the isocitrate and isopropylmalate dehydrogenases family.; Title: similarity to 3-isopropylmalate dehydrogenase leuB - Sulfolobus sp.; See PMID 9023199
An15g02510	Remark: blastp matches are unspecific.; Title: weak similarity to prokaryotic essential gene #5987 from patent WO200277183-A2 - Bacteroides fragilis
An15g02540	Title: strong similarity to hypothetical protein encoded by An18g01500 - Aspergillus niger
An15g02550	Title: strong similarity to hypothetical protein encoded by An19g00370 - Aspergillus niger
An15g02560	Remark: blastp matches are only due to repetitive amino acids.
An15g02570	Title: weak similarity to precursor of agglutinin isolectin 1 - Triticum aestivum
An15g02580	Title: strong similarity to hypothetical protein encoded by An16g02740 - Aspergillus niger
An15g02590	Catalytic activity: human DMGDH catalyzes the reaction N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor.; Function: human dimethylglycine dehydrogenase (DMGDH) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase.; Title: strong similarity to dimethylglycine dehydrogenase precursor DMGDH - Homo sapiens; localisation:mitochondrion; See PMID 11231903
An15g02610	Function: aphA-6 of A. baumannii phosphorylates, and thereby inactivates, the antibiotic kanamycin and structurally related aminoglycosides.; Title: similarity to kanamycin kinase type IV aphA-6 - Acinetobacter baumannii; See PMID 2846986
An15g02620	Title: weak similarity to fungal ZBC protein sequence #116 from patent WO200224865-A2 - Unclassified organism
An15g02630	Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC of A. terreus is involved in lovastatin production.; Similarity: the ORF shows similarity to several unspecified oxidoreductases.; Title: similarity to enoyl reductase lovC from patent WO200037629-A2 - Aspergillus terreus; See PMID 10334994
An15g02640	Title: similarity to human cancer associated protein sequence SEQ ID NO:1313 from patent WO200055350-A1 - Homo sapiens
An15g02650	Title: similarity to hypothetical protein CC3092 -Caulobacter crescentus
An15g02660	Title: strong similarity to essential protein SEQ ID NO:22 from patent WO2003076464-A2 - Aspergillus fumigatus
An15g02670	Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Title: strong similarity to essential protein #22 from patent WO2003076464-A2 - Aspergillus fumigatus [truncated ORF]
An15g02680	Function: tetA from E. coli encodes a tetracycline cation/proton antiporter.; Function: tetA from E. coli is necessary for tetracycline resistance.; Title: strong similarity to tetracyclin resistance protein tetA - Escherichia coli; plasma membrane; See PMID 11069672; See PMID 6310527
An15g02690	Catalytic activity: protoporphyrin + Fe(2+) <=> protoheme + 2 H(+).; Function: catalyzes the insertion of iron into protoporphyrin to produce heme.; Remark: Danio rerio = zebrafish.; Title: strong similarity to ferrochelatase fch -Danio rerio; See PMID 10985389
An15g02700	Function: Ku70 of M. musculus has a role in chromosome translocation.; Function: Ku70 of M. musculus is a ssDNA/ATP-dependent helicase.; Function: the DNA helicase II complex binds preferentially to fork-like ends of dsDNA in a cell cycle-dependent manner.; Similarity: belongs to the ATP-dependent DNA helicase II 70kDa subunit family.; Title: strong similarity to ATP-dependent DNA helicase II subunit Ku70 - Mus musculus; nucleus; See PMID 10689133; See PMID 1701785
An15g02710	Title: strong similarity to hypothetical protein encoded by An02g01160 - Aspergillus niger
An15g02720	Title: weak similarity to hypothetical hsp70-related protein ORP150RP - Leishmania major
An15g02730	Title: weak similarity to cancer associated protein sequence SEQ ID NO:1409 from patent WO200055350-A1 - Homo sapiens
An15g02740	Function: apsA of A. nidulans is required for nuclear positioning and completion of asexual development.; Phenotype: apsA mutants of A. nidulans are partially blocked in conidiation (asexual sporulation) due to failure of the organized migration of nuclei into the conidiophore metulae.; Phenotype: apsA mutants of A. nidulans have a slightly reduced hyphal growth rate and en irregular distribution of nuclei in vegetative hyphae.; Remark: Emericella nidulans = Aspergillus nidulans.; Title: strong similarity to anucleate primary sterigmata gene apsA - Aspergillus nidulans; See PMID 8025681; See PMID 7860626
An15g02750	Title: similarity to hypothetical protein B13N4.250 - Neurospora crassa
An15g02760	Complex: Rvs167 from S. cerevisiae may be part of a cytoskeletal complex with Vrp1, Rvs161 and Sac6.; Function: Rvs167 from S. cerevisiae affects actin distribution and bipolar budding.; Phenotype: rvs167 mutants from S. cerevisiae has reduced viability upon starvation.; Phenotype: rvs167 mutants from S. cerevisiae show defectes in sporulation.; Remark: the synonym for Rvs167 from S. cerevisiae is YDR388w.; Title: strong similarity to protein involved in actin distribution and bipolar budding Rsv167 -Saccharomyces cerevisiae; cytoskeleton; See PMID 9395067; See PMID 9434108; See PMID 10992286
An15g02770	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An15g02780	Remark: about the EST of patent WO200056762-A2 are no further informations available.; Title: strong similarity to EST SEQ ID NO:4136 from patent WO200056762-A2 - Aspergillus niger
An15g02800	Title: weak similarity to protamine I-1 - Chrysemys picta
An15g02810	Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O <=> D-myo-inositol 1,4-bisphosphate + phosphate.; Remark: the synonyms for Inp52 from S. cerevisiae are Sjl2, Pie3 and YNL106c.; Similarity: Inp52 from S. cerevisiae belongs to the Inositol-1,4,5-trisphosphate 5-phosphatase type II family.; Title: similarity to phosphatidylinositol phosphate phosphatase Inp52 - Saccharomyces cerevisiae; See PMID 9560389; See PMID 10029994
An15g02820	Catalytic activity: ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.; Cofactor: Biotin, Manganese and acetyl-CoA.; Function: pyruvate carboxylase pcb catalyzes tissue specific the initial reactions of glucose (liver,kidney) and lipid (adipose tissue,liver,brain) synthesis from pyruvate.; Title: strong similarity to pyruvate carboxylase pcb - Homo sapiens; See PMID 7918683; See PMID 3555348; See PMID 6548474
An15g02830	Catalytic activity: ATP + Propanoyl-CoA + HCO3- = ADP + Orthophosphate + (S)-Methylmalonyl-CoA; Cofactor: Biotin; Function: PCCB of H. sapiens is a biotin-dependent enzyme involved in the degradation of branched-chain amino acids, fatty acids with odd-numbered chain lengths, and other metabolites.; Remark: PCCB of H. sapiens is a biotinyl-protein,carboxylates butanoyl-CoA and catalyses transcarboxylation.; Title: strong similarity to propionyl-CoA carboxylase beta chain precursor PCCB - Homo sapiens; See PMID 2154743; See PMID 3460076
An15g02840	Title: strong similarity to hypothetical protein CAE76274.1 - Neurospora crassa
An15g02860	Catalytic activity: trans-2,3-Didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-Tetradehydroacyl-CoA + NADPH.; Phenotype: Sps19 from S. cerevisiae is dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate.; Remark: ORF contains 1 frameshift, due to a putative sequencing error.; Remark: synonyms for Sps19 from S. cerevisiae are Spx19 and YNL202w.; Title: strong similarity to peroxisomal 2,4-dienoyl-CoA reductase involved in sporulation Sps19 -Saccharomyces cerevisiae [putative sequencing error]; peroxisome; See PMID 7969036; See PMID 9268358; See PMID 9427398
An15g02870	Similarity: the similarities are based on repetetive structures.; Title: similarity to Kaposis sarcoma-associated herpesvirus glycoprotein M - Herpesvirus 8; See PMID 9151804
An15g02880	Similarity: the ORF also shows strong similarity to the EST an_2290 from Aspergillus niger.; Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to bZIP transcription factor L-Maf - Gallus gallus
An15g02890	Function: Mic1 from S. cerevisiae is an efficient GTPase-activating protein for Ypt6 and Sec4.; Remark: Mic1 from S. cerevisiae interacts with the transcription factor Mac1.; Remark: synonyms for Mic1 from S. cerevisiae are Mdr1, Gyp2 and YGR100w.; Title: strong similarity to GTPase-activating protein Mic1 - Saccharomyces cerevisiae; See PMID 10559187
An15g02900	Remark: ROM1 from S. cerevisiae is a GDP-GTP exchange protein (GEP) for the Rho1p SmallGTP-binding protein.; Remark: the predicted ORF seems approximately 600 aa longer than the found homologues.; Title: similarity to GDP/GTP exchange protein Rom1 -Saccharomyces cerevisiae; See PMID 8641285
An15g02910	Remark: the ORF is short in length (49 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An15g02930	Remark: CDR4 seems to be involved in fluconazole resistance in C. albicans.; Title: strong similarity to ABC transporter CDR4 -Candida albicans; See PMID 9767132
An15g02960	Title: similarity to hypothetical protein CAD37071.1 - Neurospora crassa
An15g02980	Catalytic activity: 1-CARBOXYVINYL CARBOXYPHOSPHONATE = 3-(HYDROHYDROXYPHOSPHORYL)PYRUVATE + CO(2).; Function: the Streptomyces hygroscopicus homolog BCPA catalyzes the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos (BA). BCPA catalyzes the rearrangement of the carboxyphosphono group of CPEP to form the C-P bond of phosphoenolpyruvate.; Pathway: Bialaphos biosynthesis pathway (BAP).; Title: strong similarity to carboxyphosphonoenolpyruvate mutase bcpA - Streptomyces hygroscopicus
An15g02990	Catalytic activity: S-adenosyl-L-methionine + catechol <=> S-adenosyl-L-homocysteine + guaiacol.; Function: the murine homolog COMT is a Mg2+-dependent enzyme which catalyses the transfer of methyl groups from S-adenosyl methionine to a hydroxyl group of a catecholic substrate. It converts, and thereby inactivates, dopamine to 3-methoxytyramine and norepinephrine to noemetanephrine.; Remark: COMT also shortens the biological half-lives of certain neuroactive drugs, like L-dopa, alpha-methyl dopa and isoproterenol.; Title: strong similarity to catechol-O-methyltransferase COMT from patent WO9832878-A1 - Mus sp.
An15g03010	Title: strong similarity to hypothetical protein B7F18.180 - Neurospora crassa
An15g03020	Complex: the P. patens RPN10 is part of the 26S proteasome, the primary protease of the ubiquitin-mediated proteolytic system in eukaryotes.; Function: the P. patens RPN10 has affinity for multiubiquitin chains in vitro and as a result may function as a receptor for ubiquitinated substrates.; Phenotype: the disruption of the rpn10 gene in P. patens shows strains which are viable but are under developmental arrest, generating abnormal caulonema that are unable to form buds and gametophores.; Title: strong similarity to proteasome 19S regulatory particle multiubiquitin chain binding subunit RPN10 - Physcomitrella patens; See PMID 10449580
An15g03030	Title: strong similarity to hypothetical protein B7F18.200 - Neurospora crassa
An15g03040	Remark: Note that in the older literature, some RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family, albeit with similar Cys-spacing.; Title: strong similarity to hypothetical LIM domain protein - Schizosaccharomyces pombe
An15g03080	Function: E2 enzymes/ubc's in general catalyse the covalent attachment of ubiquitin to other target proteins or ubiquitin itself.; Golgi; Similarity: contains a domain typically for ubiquitin conjugating enzymes E2/ubc's. So does the A. thaliana homolog MJK13.; Similarity: the ORF shows similarity to a C-terminal region of M musculus BRUCE protein, but not to the N-terminally located baculovirus inhibitor of apoptosis repeat (BIR) motif.; Title: similarity to BIR repeat containing ubiquitin-conjugating enzyme BRUCE - Mus musculus
An15g03090	Catalytic activity: 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta -carboxylate + NAD(+) <=> 4-alpha-methyl-5-alpha-cholest-7-en-3-one + CO(2) + NADH.; Function: the C. albicans homolog ERG26 is a C-3 sterol dehydrogenase/C-4 decarboxylase; Pathway: C. albicans ERG26 is involved in ergosterol biosynthesis.; Title: strong similarity to C-3 sterol dehydrogenase/C-4 decarboxylase ERG26 - Candida albicans
An15g03100	Catalytic activity: the A. parasiticus homolog versicolorin B synthase vsb catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Function: aflatoxin B1 is a potent environmental carcinogen produced by certain strains of Aspergillus. Central to the biosynthesis of this mycotoxin is the reaction catalyzed by versicolorin B synthase vbs.; Pathway: aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689
An15g03140	Function: overexpression of S. pombe CEK1 complements a fission yeast mutation that blocks anaphase.; Remark: the S. pombe homolog CEK1 is significantly shorter.; Title: similarity to protein kinase cek1p -Schizosaccharomyces pombe
An15g03150	Title: strong similarity to hypothetical protein SPCC1183.11 - Schizosaccharomyces pombe
An15g03190	Complex: the E. nidulans homolog tubB encodes one of two alpha-tubulin isoforms that are required for microtubule formation.; Function: Microtubules are polymers that are essential for, among other functions, cell transport and cell division in all eukaryotes. Gamma-tubulin is necessary to initiate the assembly of alpha-beta tubulin heterodimers into microtubule polymers.; Title: strong similarity to hypothetical tubulin alpha-2 chain tubB - Aspergillus nidulans
An15g03200	Function: the H. sapiens homolog MUP1 is a mitochondrial deoxynucleotide carrier (TC 2. A. 29). Its physiological role is probably to supply deoxynucleotides to the mitochondrial matrix for conversion to triphosphates and incorporation into mitochondrial DNA.; Title: strong similarity to mitochondrial uncoupling protein MUP1 from patent WO200061614-A2 - Homo sapiens; localisation:mitochondrion; See PMID 11226231
An15g03210	Catalytic activity: H. sapiens BBH converts gamma-butyrobetaine (4-trimethylammoniobutanoate),alpha-ketoglutarate and molecular oxygen into carnitine (3-hydroxy-4-trimethylammoniobutanoate), succinate and CO2; Function: the H. sapiens homolog gamma-butyrobetaine hydroxylase BBH is a alpha-ketoglutarate-dependent dioxygenase. It mediates the last step in carnitine biosynthesis and uses iron (2+) and ascorbate as co-factors.; Remark: gamma-butyrobetaine hydroxylase is inhibited by MET-88, 3-(2,2,2-trimethylhydrazinium) propionate.; Title: strong similarity to gamma-butyrobetaine hydroxylase BBH - Homo sapiens
An15g03220	Similarity: shows strong similarity to thioredoxin superfamily.; Title: strong similarity to member of the subfamily of yeast glutaredoxins Grx4 - Saccharomyces cerevisiae; See PMID 10567543
An15g03230	Title: strong similarity to hypothetical exonuclease - Schizosaccharomyces pombe
An15g03240	Title: weak similarity to hypothetical retrotransposon protein AAK72287.1 - Oryza sativa
An15g03260	Catalytic activity: the threonin aldolase converts L-threonine to glycine and acetaldehyde.; Remark: riboflavin production in the filamentous fungus Ashbya gossypii is limited by glycine and is enhanced by activation of the threonin aldolase.; Remark: the A. gossypii gly1 gene encoding the threonine aldolase was isolated by heterologous complementation of the glycine-auxotrophic S. cerevisiae strain YM13 with a genomic library from A. gossypii.; Title: strong similarity to threonine aldolase -Ashbya gossypii; See PMID 9797278
An15g03280	Catalytic activity: Rad53p phosphorylates proteins on serine, threonine, and tyrosine.; Function: S. cerevisiae Rad53p is required for DNA damage-induced checkpoint arest in G1, S/M, and G2/M in mitosis. It is dispensable for sporulation but required for wild-type spore viability.; Induction: S. cerevisiae Mec1p and Tel1p regulate Rad53p phosphorylation.; Remark: alternative gene names for the S. cerevisiae homolog RAD53 are LSD1, MEC2 and SPK1.; Title: strong similarity to protein kinase RAD53 from patent US5674996-A - Saccharomyces cerevisiae
An15g03330	Catalytic activity: Bed1p is a alpha-1,6-mannosyltransferase.; Complex: Bed1p, Anp1p, Mnn9p, Mnn11p, and Hoc1p are subunits of the same complex.; Function: S. cerevisiae Bed1p gene is a component of one of two complexes in the cis-Golgi, which elongates the alpha-1,6-linked mannose backbone of many cell wall proteins in yeast. Bed1p/Mnn10p and Mnn11p are responsible for the majority of the alpha-1, 6- polymerizing activity of the complex.; Title: strong similarity to galactosyltransferase Bed1 - Saccharomyces cerevisiae
An15g03340	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3902 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to hypothetical protein NUO-12.3 - Neurospora crassa
An15g03350	Function: the E. nidulans homolog PalC participates in regulation of gene expression by ambient (extracellular) pH.; Pathway: the E. nidulans palA, B, C, F, H, and I genes encode components of an ambient pH signal transduction pathway which regulates the zinc finger transcription factor pacC.; Title: strong similarity to palC - Aspergillus nidulans
An15g03360	Remark: TAF47 S. cerevisiae is a TAF(II) complex (TBP-associated protein complex) component.; Remark: also similarity to Yeast transcriptional activator factor TAF-47 protein patent WO9749828-A.; Remark: alternate name is YPL011c.; Title: similarity to component of the TBP-associated protein complex Taf47 - Saccharomyces cerevisiae; See PMID 9845373
An15g03370	Remark: ptr6, causes accumulation of mRNA in the nucleus and inhibition of growth at the nonpermissive temperature. Ptr6p is required for mRNA transport and is a Schizosaccharomyces pombe homologue of yTAFII67 and hTAFII55.; Title: strong similarity to subunit of transcription initiation factor TFIID ptr6p - Schizosaccharomyces pombe; nucleus; See PMID 10388808
An15g03390	Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 38749 patent EP1033405-A2.; Similarity: belongs to enoyl-CoA hydratases family.; Title: strong similarity to protein fragment SEQ ID NO:38749 from patent EP1033405-A2 - Arabidopsis thaliana
An15g03410	Title: weak similarity to hypothetical protein B12J7.240 - Neurospora crassa
An15g03420	Remark: similarity to EST an_0838 Aspergillus niger.; Title: strong similarity to hypothetical protein YER049w - Saccharomyces cerevisiae
An15g03450	Title: similarity to EST an_0903 - Aspergillus niger
An15g03490	Title: strong similarity to hypothetical bHLH transcription factor hpa3 - Aspergillus nidulans
An15g03500	Title: weak similarity to hypothetical protein AAP68395.1 - Oryza sativa
An15g03530	Catalytic activity: a dinucleotide + H2O = 2 mononucleotide; hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.; Function: human PC-1 is an ecto-enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities.; Pathway: purine metabolism; starch and sucrose metabolism; riboflavin metabolism; nicotinate and nicotinamide metabolism; pantothenate and CoA biosynthesis.; Remark: he murine cell membrane glycoprotein PC-1 is a homodimer with restricted tissue distribution, being first characterized in plasma cells. In situ chromosomal hybridization localizes the gene for human PC-1 to chromosome 6q22-q23, a common site for deletions in human lymphoid neoplasia.; Similarity: belongs to the nucleotide pyrophosphatases.; Title: strong similarity to plasma cell membrane glycoprotein PC-1 - Homo sapiens; See PMID 1315502; See PMID 2211644; See PMID 8001561
An15g03540	Remark: respiratory deficient pet mutants of S. cerevisiae assigned to complementation group G2 define a gene, named BCS1, whose product is shown to be necessary for the expression of functional ubiquinol-cytochrome c reductase (bc1) complex. The BCS1 protein is anchored in the mitochondrial inner membrane via a single transmembrane domain and has an N(out)-C(in) topology. Unlike the majority of nuclear encoded mitochondrial preproteins, the BCS1 protein does not contain an N-terminal targeting sequence.; Title: strong similarity to protein precursor Bcs1 -Saccharomyces cerevisiae; See PMID 1327750; See PMID 8599931
An15g03550	Title: weak similarity to protopectinase from patent WO9806832-A1 - Bacillus subtilis
An15g03570	Remark: similarity to human secreted protein sequence SEQ ID NO:154 patent WO200004140-A1.; Title: similarity to secreted protein SEQ ID NO:154 from patent WO200004140-A1 - Homo sapiens
An15g03580	Function: mouse KIF1B works as a monomeric motor for anterograde transport of mitochondria.; Remark: KIF1B is expressed ubiquitously in various kinds of tissues. In situ hybridization revealed that KIF1B is expressed abundantly in differentiated nerve cells.; Remark: also strong similarity to Thermomyces lanuginosus kinesin motor protein TL-gamma patent WO9937659-A1 but this protein is only 784 amino acis in lenght.; Title: strong similarity to kinesin-like protein KIF1B - Mus musculus; See PMID 7528108
An15g03630	Remark: C-terminal truncated ORF due to end of contig.
An15g03650	Complex: the HapB, HapC and HapE proteins of A. nidulans form the complex AnCF, which binds to the CCAAT sequence in the amdS promoter of Aspergillus nidulans.; Function: in A. nidulans, AnCF regulates positively the expression of the amdS gene (encoding acetamidase) and two penicillin biosynthesis genes (ipnA and aatA). in A. nidulans, AnCF negatively regulates the expression of lysF,which encodes homoaconitase.; Phenotype: A. nidulans strains with deletions of each of the hapB, hapC, and hapE genes have identical phenotypes of slow growth, poor conidiation, and reduced expression of amdS.; Regulation: the A. nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene, which contains two inversely oriented,conserved CCAAT boxes (box alpha and box beta).; Similarity: the predicted A. niger protein shows strong similarity to the HapB protein of A. nidulans. a domain of approximately 65 amino acids is conserved in fungal, plant and vertebrate species.; Title: strong similarity to protein hapB -Aspergillus nidulans; nucleus; See PMID 9858535; See PMID 11243777; See PMID 11285740
An15g03670	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical C2H2-type zinc-finger protein - Schizosaccharomyces pombe
An15g03680	Title: similarity to hypothetical protein CAC86582.1 - Podospora anserina
An15g03710	Title: weak similarity to hypothetical transcription regulator meaB - Aspergillus nidulans; See PMID 8690087
An15g03720	Remark: Hap1 of S. cerevisiae binds to two classes of DNA elements, UAS1/CYC1 and UAS/CYC7, and permits differential transcriptional activation at these sites. in yeast, oxygen sensing and heme signaling are primarily mediated by the heme activator protein Hap1, which, in response to heme, activates the transcription of genes required for respiration and for controlling oxidative damage.; Similarity: the predicted A. niger protein shows weak similarity to the CYC1/CYP3/HAP1 transcription activator of S. cerevisiae which belongs to the unassigned GAL4-type zinc cluster proteins.; Title: weak similarity to CYC1/CYP3 transcription activator Hap1 - Saccharomyces cerevisiae; See PMID 10617612; See PMID 11212295; See PMID 2643482
An15g03730	Similarity: the predicted A. niger protein shows strong similarity to hypothetical proteins of several procaryotic species.; Title: strong similarity to hypothetical 41.5 kD protein of cosmid clone 65G3 - Zymomonas mobilis
An15g03740	Function: A. parasiticus adhA catalyses the conversion of 5'-hydroxyaverantin (HAVN) to 5'-ketoaverantin, the open-chain form of averufin (AVF) in the synthesis of aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the protein shows strong similarity to several mammalian NAD+-dependent 15-hydroxyprostaglandin dehydrogenases.; Title: similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914
An15g03750	Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to the adhesion protease of patent WO0109293-A/1 of H. sapiens (AC# CAC33153) and strong similarity to probable zinc metallopeptidase of S. pombe.; Title: similarity to adhesion protease from patent WO0109293-A - Homo sapiens
An15g03760	Title: weak similarity to hypothetical protein CAD21317.1 - Neurospora crassa
An15g03770	Catalytic activity: MR1 of M. ramanniana catalyses the reaction acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.; Function: MR1 of M. ramanniana is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates.; Remark: the DNA sequence encoding MR1 of M. ramanniana can be used to modify the triacylglycerol and lipid composition of plant cells.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence diacylglycerol acyl transferase (MR1) of patent WO200001713-A2 (AC# AAY68640) of M. ramanniana.; Title: strong similarity to diacylglycerol acyl transferase MR1 from patent WO200001713-A2 - Mortierella ramanniana
An15g03780	Complex: Moe1 from S. pombe interacts with a Ras effector, Scd1 of S. pombe, Mal3 of S. pombe, which is a member of a conserved family of microtubule-binding proteins (includes human EB1 and budding yeast Bim1) and Yin6 of S. pombe, which is a homolog of the human breast cancer gene Int6.; Function: Moe1 from S. pombe is a negative regulator for microtubule dynamics which induces instabilty in microtubules and affects spindle formation.; Pathway: Moe1 from S. pombe is a component of the ras protooncogene mediated signal transduction pathway that regulates cell proliferation.; Phenotype: a moe1 null (Delta) mutant exhibits numerous phenotypes indicative of abnormal microtubule functioning, including an abnormality in the spindle. moe1Delta mutants are resistant to microtubule destabilizing agents; moreover, moe1Delta rescued the growth defects of tubulin mutants containing unstable microtubules.; Similarity: the predicted A. niger protein shows strong similarity to Moe1 from S. pombe and several hypothetical proteins from various eucaryotic organisms,which belong to the eIF3S7 family.; Title: strong similarity to ras pathway interacting protein moe1p - Schizosaccharomyces pombe; nucleus; See PMID 9892665; See PMID 11102508; See PMID 11121040; See PMID 11268035
An15g03800	Similarity: the nucleotide sequence of the ORF shows strong similarity to two ESTs of A. niger (an_3228 and an_3303).; Title: strong similarity to EST an_3228 -Aspergillus niger
An15g03810	Title: similarity to hypothetical protein mlr1783 -Mesorhizobium loti
An15g03820	Catalytic activity: an aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2).; Function: a double bond conjugated with a primary alcohol is necessary for substrate recognition by P. eryngii aao, and that activity is increased by the presence of additional conjugated double bonds and electron donor groups.; Function: aao from P. eryngii is an extracellular enzyme and constitutes a source for H(2)O(2) required in lignin biodegradation.; Function: aao from P. eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; extracellular/secretion proteins; See PMID 10377251; See PMID 1425667
An15g03860	Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: a putative sequencing error results in an frameshift.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 10320578
An15g03900	Function: Zinc-replete cells accumulate zinc in the vacuole via the Zrc1p (and Cot1p) transporters.; Localization: a Zrc1-GFP fusion protein is localized to the vacuolar membrane in S. cerevisiae.; Regulation: the Zap1p transcriptional activator of S. cerevisiae induces the expression of ZRC1 when the intracellular zinc level is decreased and this induction is repressed by zinc. Zap1p also activates zinc transporters of the ZIP family (Zrt1p, Zrt2p and Zrt3p).; Remark: ZRC1 from S. cerevisiae was initially identified as a gene conferring resistance to zinc and cadmium ions. the oxidative-stress-resistance (OSR) gene from S. cerevisiae, which enhances resistance against oxidative stress caused by lipid hydroperoxide, was isolated independently and found to be identical to ZRC1.; Similarity: the predicted A. niger protein shows strong similarity to heavy metal ion resistance protein ZRC1/OSD from S. cerevisiae and additional heavy metal ion transporting proteins from S. cerevisiae and other species. ZRC1 from S. cerevisiae belongs to the cation diffusion facilitator (CDF) family.; Title: strong similarity to heavy metal ion resistance protein Zrc1 - Saccharomyces cerevisiae; vacuole; See PMID 8867889; See PMID 10856230; See PMID 11027563; See PMID 11263974; See PMID 2693940
An15g03910	Remark: CDC1 protein of S. cerevisiae plays a role in manganese homeostasis.; Remark: the N. crassa mutant frost has a hyperbranching phenotype that can be corrected by adding Ca(2+).; Remark: the fr mutant of N. crassa was sensitive to Mn(2+), and a revertant allele whose product differs by one amino acid was tolerant to Mn(2+). Mn(2+) depletion induced the wild-type strain to hyperbranch, resulting in a morphology similar to that of fr. the fr mutant of N. crassa was also sensitive to calcineurin inhibitors.; Similarity: the predicted A. niger protein shows strong similarity to the frost gene (fr) of N. crassa and to the CDC1 proteins from the yeasts S. cerevisiae and S. pombe.; Title: strong similarity to frost gene fr -Neurospora crassa; See PMID 10669587
An15g03940	Function: monosaccharide transporter Mst-1 of A. muscaria is involved in the active uptake of monosaccharides.; Induction: monosaccharide transporter Mst-1 of A. muscaria is upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Similarity: the predicted A. niger protein shows strong similarity to the monosaccharide transporter Mst-1 of A. muscaria, which belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An15g03950	Catalytic activity: lingual triacylglycerol lipase of R. norvegicus catalyses the reaction triacylglycerol + H(2)O = diacylglycerol + a fatty acid anion.; Pathway: lingual triacylglycerol lipase of R. norvegicus catalyses the first step in glycerolipid catabolism.; Title: strong similarity to precursor of lingual triacylglycerol lipase - Rattus norvegicus; See PMID 3839077
An15g03980	Catalytic activity: oxalate decarboxylase from C. velutipes catalyses the reaction oxalate = formate + CO(2).; Pathway: oxalate decarboxylase from C. velutipes is involved in glyoxylate and dicarboxylate metabolism.; Remark: an oxalate decarboxylase (APOXD) from A. phoenices is covered by patent WO9842827-A2 (AC# AAW79948). APOXD may be used for e. g. degrading oxalic acid,protecting against oxalic toxicity or as a selectable marker in plants.; Remark: oxalic acid is present as nutritional stress in many crop plants like Amaranth and Lathyrus. oxalic acid has also been found to be involved in the attacking mechanism of several phytopathogenic fungi.; Remark: transgenic tobacco and tomato plants expressing oxalate decarboxylase from C. velutipes show remarkable resistance to phytopathogenic fungus Sclerotinia sclerotiorum that utilizes oxalic acid during infestation.; Title: strong similarity to oxalate decarboxylase -Collybia velutipes; See PMID 10702293
An15g03990	Function: OMST-oxidoreductase from A. flavus converts O-methylsterigmatocystin (OMST) to aflatoxin B1.; Pathway: OMST-oxidoreductase from A. flavus catalyses the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the predicted A. niger protein shows strong similarity to OMST-oxidoreductase (ord1) from A. flavus, which belongs to the cytochrome P-450-type monooxygenase gene family CYP64.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099; See PMID 7793957
An15g04010	Title: strong similarity to hypothetical protein encoded by An14g06160 - Aspergillus niger
An15g04030	Title: questionable ORF
An15g04040	Function: the toxins have activity against Lepidopteran insects and Coleopteran insects, and are active against strains resistant to known insecticides.; Remark: P. luminescens is a member of the Enterobacteriaceae family and is a symbiotic bacterium of nematodes of the genus Heterorhabditis; the nematodes colonise insect larvae, kill them, and their offspring feed on the dead larvae; however, the insecticidal agents are produced by P. luminescens rather than the nematodes.; Remark: the 176 kD insecticidal toxin from P. luminescens is one of five insecticidal toxins encoded by ORFs arranged in an operon-like structure in a 9. 7kb fragment of P. luminescens DNA.; Similarity: the predicted ORF is also very similar to the nematicidal protein 2 produced by Xenorhabdus bovienii, still unpublished.; Title: strong similarity to 176 kD insecticidal toxin from patent WO9942589-A2 - Photorhabdus luminescens
An15g04050	Phenotype: KHA1 mutants in S. cerevisiae accumulate K+, show net influx without a significant difference in efflux, as well as an increased growth rate, smaller cells,and twice the cell yield per glucose used; mutant cells also produce a greater acidification of the medium coincident with an internal pH alkalinization and show a higher oxygen consumption velocity.; Remark: KHA1 of S. cerevisiae is also known as YJL094c.; Title: strong similarity to K+/H+ exchanger Kha1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 9348664; See PMID 9678606; See PMID 9811642; See PMID 10628851
An15g04060	Function: S. cerevisiae Flr1 is a transmembrane transporter confering fluconazole resistance.; Induction: S. cerevisiae Flr1 is transcriptionally regulated by the Cap1 and yAP-1 proteins.; Remark: YBR008c is the systematic name for S. cerevisiae Flr1.; Similarity: S. cerevisiae Flr1 belongs to the major facilitator family (TC 2. A. 1).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926
An15g04100	Pathway: the DOX proteins constitute a complete upper naphthalene catabolic pathway.; Remark: DoxF is one of the DOX proteins, converting naphthalene to salicylate and phenanthrene to 1-hydroxy-2-naphthoic acid.; Title: strong similarity to salicylaldehyde dehydrogenase doxF - Pseudomonas sp.; See PMID 8226631
An15g04110	Remark: the ORF has an unusual exon/intron structure.; Title: weak similarity to hypothetical protein encoded by An08g09080 - Aspergillus niger
An15g04120	Title: strong similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger
An15g04130	Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Title: similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529
An15g04140	Function: PKS1 from C. heterostrophus encodes a multifunctional polyketide synthase with six catalytic domains: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase and acyl carrier protein.; Phenotype: PKS1 in race T of the fungal pathogen C. heterostrophus was inactivated by targeted gene disruption,T-toxin production and high virulence were eliminated,indicating that this PKS is required for fungal virulence.; Remark: race T of the fungal pathogen C. heterostrophus may have acquired PKS1 by horizontal DNA-transfer rather than by vertical inheritance from an ancestral strain.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776
An15g04150	Function: the introduction of extra copies of Orf11 genes in a S. coelicolor actIII mutant restores the ability to produce actinorhodin.; Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Remark: the disruption of the Orf11 gene in S. coelicolor appears to have no significant effect on the production of actinorhodin.; Title: strong similarity to oxidoreductase involved in actinorhodin production encoded by Orf11 - Streptomyces lividans; See PMID 10400594
An15g04160	Remark: it is assumed, that this sequence probably has been incorporated into the A. niger sample and is a putative cloning artefact.; Remark: the predicted ORF is identical to exodeoxyribonuclease I sbc originally found in E. coli.; Title: strong similarity to exodeoxyribonuclease I sbc - Escherichia coli [putative cloning artefact]
An15g04170	Remark: the distance to ORF 110WK is only 15 base pairs.
An15g04180	Title: strong similarity to hypothetical cytochrome P450 related protein B13N20.260 - Neurospora crassa
An15g04190	Title: similarity to hypothetical protein encoded by An13g03430 - Aspergillus niger
An15g04200	Title: similarity to hypothetical protein encoded by An02g01120 - Aspergillus niger
An15g04210	Similarity: the predicted ORF shows strong similarity to putative oxidoreductases with various substrate specificities and also strong homology to potassium channels from some species.; Title: strong similarity to hypothetical oxidoreductase SPAC977.14c - Schizosaccharomyces pombe
An15g04220	Title: strong similarity to hypothetical protein EAA59582.1 - Aspergillus nidulans
An15g04230	Catalytic activity: dihydrodipicolinate synthases catalyse L-aspartate 4-semialdehyde + pyruvate <=> dihydrodipicolinate + 2 H(2)O.; Function: dapA of C. glutamicum is involved in the lysine biosynthesis by catalyzing the first step in diaminopimelate and lysine biosynthesis.; Similarity: the ORF shows similarity to several bacterial dihydrodipicolinate synthases.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8659901; See PMID 9559056; See PMID 10498736
An15g04260	Title: similarity to hypothetical protein MRI1 -Arabidopsis thaliana
An15g04270	Similarity: shows strong similarity to several hexose transporter.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 1339361; See PMID 2175387; See PMID 2835177; See PMID 2976880; See PMID 3049934
An15g04280	Function: in S. cerevisiae biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway requires NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate by AYR1 before the second step of acylation.; Function: phosphatidic acid is a key intermediate in the formation of glycerophospholipids and triacylglycerols.; Localization: in S. cerevisiae lipid particles and the endoplasmic reticulum harbor 1-acyldihydroxyacetone-phosphate reductase (ADR) activity.; Pathway: dihydroxyacetone phosphate pathway.; Remark: the systematic genename of AYR1 is YIL124w.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610
An15g04290	Catalytic activity: 6-hydroxy-D-nicotine oxidases catalyze the conversion of (D)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2.; Pathway: 6-hydroxy-D-nicotine oxidases are involved in the degradation of nicotine.; Similarity: shows similarity to several putative oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans
An15g04300	Title: strong similarity to hypothetical protein encoded by EAA61985.1 - Aspergillus nidulans
An15g04310	Catalytic activity: alcohol dehydrogenases convert alcohol + NAD(+) to aldehyde or ketone + NADH.; Similarity: shows strong similarity to several putative alcohol dehydrogenases and oxidoreductases.; Title: strong similarity to alcohol dehydrogenase adhT - Bacillus stearothermophilus
An15g04320	Similarity: N-terminal third shows similarity to N-terminal third of the A. nidulans facB.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans
An15g04330	Remark: DAL5 of S. cerevsiae encodes a component of the allantoate transport system.; Remark: N-terminally truncated ORF due to contig border.; Remark: the relatively high basal level of expression of S. cerevisiae DAL5 did not increase further upon addition of allantoin pathway intermediates.; Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae [truncated ORF]; See PMID 3275614; See PMID 3301804
An15g04340	Function: Dal5 from S. cerevisiae is a component of the allantoate transport system.; Regulation: DAL5 gene from S. cerevisiae is constitutively expressed but repressed when a nitrogen source was provided.; Remark: synonyms for Dal5 from S. cerevisiae are UreP1, J2230 and YJR152w.; Similarity: Dal5 from S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3294799; See PMID 3301804
An15g04350	Similarity: the ORF encoded protein shows also strong similarities to other oxidoreductases.; Title: strong similarity to hypothetical oxidoreductase encoded by mll6520 - Mesorhizobium loti
An15g04360	Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide.; Remark: Acts on acids of short-chain lengths, C(2) to C(4), with inversion of configuration at C-2.; Title: similarity to haloacid dehalogenase dhlB -Xanthobacter autotrophicus; See PMID 1744048
An15g04370	Catalytic activity: hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl- hydroxyproline analogs.; Remark: Microbacterium esteraromaticum = Aureobacterium esteraromaticum.; Title: similarity to proline dipeptidase from patent JP11318454-A - Microbacterium esteraromaticum
An15g04380	Catalytic activity: PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism.; Remark: Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate.; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: PhacA is a novel cytochrome P450 monooxygenase.; Title: strong similarity to phenylacetate 2-hydroxylase phacA - Aspergillus nidulans; endoplasmatic reticulum; See PMID 10329644
An15g04390	Function: hdhA from E. coli catalyses the oxidation of the 7-alpha-hydroxyl group of bile acids and alcohols both in their free and conjugated forms.; Similarity: there are also strong similarities to other oxidoreductases.; Title: strong similarity to 7-alpha-hydroxysteroid dehydrogenase gene hdhA - Escherichia coli; See PMID 2007545
An15g04400	Similarity: the ORF encoded protein shows significant domain homology to binuclear Zn(2)-Cys(6) cluster domains of many fungal transcription factors.; Title: similarity to transcription factor Sip4 -Saccharomyces cerevisiae; nucleus; See PMID 9843506; See PMID 11169757
An15g04410	Function: Ppr1 from S. cerevisiaeis is a positive transcriptional regulator of the Ura1 and Ura3 genes.; Remark: the synonym for Ppr1 from S. cerevisiae is YLR014c.; Remark: the zinc finger and additional 14 amino acids of the carboxyl side of Ppr1 from S. cerevisiae are sufficient for the DNA-binding specificity.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 2118990; See PMID 6096562
An15g04420	Catalytic activity: NADH + acceptor = NAD+ + reduced acceptor.; Cofactor: FAD; contains 2 FAD molecules per subunit.; Complex: the NADH oxidase from T. brockii exists as a homohexamer.; Function: the NADH oxidase from T. brockii reduces a range of alternative electron acceptors.; Function: the role of the NADH oxidase from T. brockii is not clear.; Remark: ORF contains an internal stop codon, due to a putative sequencing error.; Remark: the NADH oxidase from T. brockii is thermostable.; Title: similarity to NADH oxidase -Thermoanaerobacter brockii [putative sequencing error]; putative sequencing error; See PMID 8357835; See PMID 1599437
An15g04440	Remark: the encoded protein of patent WO200100844-A2 is a sugar metabolism and oxidative phosphorylation protein for production or modulation of production of fine chemicals e. g. amino acids, carbohydrates or enzymes.; Title: strong similarity to protein involved in carbon metabolism and energy production from patent WO200100844-A2 - Corynebacterium glutamicum
An15g04470	Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Remark: the patent EP1033405-A2 does not provide further information about the function of the protein.; Title: similarity to protein from patent EP1033405-A2 - Arabidopsis thaliana
An15g04480	Title: similarity to hypothetical protein B13C5.110 - Neurospora crassa
An15g04490	Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Function: myoA involved in hyphal morphogenesis,vesicle migration, septal wall formation, and cell polarity.; Localization: a GFP-myoA fusion protein in Aspergillus nidulans is enriched in growing hyphal tips, at sites of septum formation and in patches at the cell cortex.; Title: strong similarity to myosin I myoA -Aspergillus nidulans; cytoskeleton; See PMID 7860631; See PMID 9756952; See PMID 10658211
An15g04510	Remark: the patent does not provide further information about the function of the protein.; Remark: the sequence of the patent EP1033405-A2 from A. thaliana was obtained by carrying out RT-PCR on all mRNAs.; Title: similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana
An15g04520	Complex: Cdc5 from S. cerevisiae is probably recruitet to origin complexes by Dbf4.; Function: Cdc5 from S. cerevisiae is a positive regulator of cyclin-specific anaphase-promoting complex (APC) activity in late mitosis.; Function: Cdc5 from S. cerevisiae is essential for the onset of Clb2p proteolysis but not for Clb5p proteolysis.; Function: Cdc5 from S. cerevisiae is involved in regulation of DNA replication.; Function: Cdc5 from S. cerevisiae is required for exit of mitosis.; Function: Cdc5 from S. cerevisiae phosphorylates Dbf4p.; Function: the degradation of Cdc5p from S. cerevisiae in G1 might provide a feedback mechanism by which the APC destroys its activator at the onset of the next cell cycle.; Induction: CDC5 transcript from S. cerevisiae accumulation peaks at the G2/M boundary.; Phenotype: cdc5-1 mutants are defective in destruction of cyclins and show a reduction in the cyclin-ubiquitin ligase activity of the anaphase-promoting complex.; Remark: synonyms for Cdc5 from S. cerevisiae are Pkx2, Msd2 and YMR001c.; Repression: Cdc5 from S. cerevisiae degraded in G1 by an anaphase-promoting complex and Hct1 dependent mechanism.; Title: similarity to polo-like protein kinase Cdc5 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 8321244; See PMID 9819423; See PMID 10594031; See PMID 10678171; See PMID 11157974
An15g04530	Function: rhaB is a polysaccharidase.; Similarity: shows only partial similarity to rhaB.; Title: weak similarity to rhamnosidase B precursor rhaB - Aspergillus aculeatus; See PMID 11319105
An15g04540	Function: contains a BTB/POZ domain that mediates homomeric dimerisation and in some instances heteromeric dimerisation in proteins mainly involved in transcriptional regulation.; Similarity: shows only partial similarity to several hypothetical proteins.; Title: weak similarity to hypothetical protein B21O8.120 - Neurospora crassa
An15g04550	Catalytic activity: endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans.; Pathway: xylan degradation.; Remark: patented enzyme is used for bleaching at increased temperatures.; Title: strong similarity to xylanase A xynA from patent WO200068396-A2 - Aspergillus niger; extracellular/secretion proteins
An15g04570	Function: enzyme of T. reesei is involved in degradation of polysaccharids.; Title: strong similarity to endoglucanase IV -Trichoderma reesei; extracellular/secretion proteins; See PMID 9370370
An15g04580	Function: it is assumed, that the A. chrysogenum protein might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: patent W14439 against protein.; Similarity: shows strong similarity to several major facilitator transport proteins of S. pombe, C. albicans,P. olsonii.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An15g04590	Function: might be a transcriptional regulator.; Similarity: shows similarity to several proteins containing Zn(II)2Cys6 clusters.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans
An15g04600	Function: P. chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin.; Function: sutB of P. chrysogenum is a sulfate transporter.; Remark: protein of P. chrysogenum is patented and there exist two similiar genes sutA and sutB.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum; plasma membrane; See PMID 10572125; See PMID 11010912
An15g04610	Catalytic activity: the enzyme of G. mastotermitis catalyses the second step in the xylose utilising pathway converting xylose to xylulosephosphate.; Pathway: Xylulose-phosphate is further degraded by the transaldolase and transketolase reactions of the pentose phosphate pathway.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis [truncated ORF]; See PMID 10661867
An15g04620	Catalytic activity: DTDP-Glucose = DTDP-4-Dehydro-6-Deoxy-D- Glucose + H(2)O.; Function: involved in anabolism pathway to biosynthesis of the O antigen of lipopolysaccharide.; Similarity: shows similarity to glucose-4,6-dehydratase enzymes of different species.; Title: similarity to dTDP-glucose-4,6-dehydratase rmlB - Streptococcus mutans; See PMID 9023194
An15g04630	Function: contains domain typical for sugar transporter.; Remark: similarity to patented sequence from Pompejus M., Kroeger B., Schroeder H., Zelder O., Haberhauer G.; 'corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport'; Patent number WO0100805-A/513, 04-JAN-2001. BASF AKTIENGESELLSCHAFT (DE).; Similarity: shows higher similarity to putative membrane transporter form S. pombe.; Title: similarity to sequence 513 from patent WO0100805 - Corynebacterium glutamicum; plasma membrane
An15g04640	Function: protein of in involved in antibiotic resistance.; Similarity: shows only partial similarity to proteins containing domain typical for acetyltransferase (GNAT) family.; Title: weak similarity to puromycin N-acetyltransferase pac - Streptomyces anulatus
An15g04650	Title: strong similarity to hypothetical protein EAA64269.1 - Aspergillus nidulans
An15g04660	Remark: blast hit against patented sequence from Pompejus M., Kroeger B., Schroeder H., Zelder O., Haberhauer G.; 'corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production' Patent number WO0100844-A/143, 04-JAN-2001. BASF AKTIENGESELLSCHAFT (DE).; Title: similarity to sequence 143 from patent WO0100844 - Corynebacterium glutamicum
An15g04670	Similarity: shows only partial similarity to the patented proteinsequence.; Title: similarity to protein #1230 from patent WO200177335-A - Listeria monocytogenes
An15g04680	Function: the polynucleotides described in AAQ97525-27 encode the human analogues of the prokaryotic mutL4 DNA repair gene.; Similarity: shows only partial similarity to mutL homologues.; Title: similarity to DNA repair protein hMLH2 from patent WO9520678-A1 - Homo sapiens; nucleus
An15g04690	Similarity: shows only partial similarity to patented protein.; Title: similarity to protein fragment SEQ ID NO:49734 from patent EP1033405-A2 - Arabidopsis thaliana
An15g04700	Title: similarity to hypothetical hydroxymethyltransferase AAL18983.1 - Salmonella typhimurium
An15g04720	Similarity: blast hits mainly result from repetitive sequences.; Title: weak similarity to transactivator EBNA-2 -Herpesvirus papio HVP
An15g04740	Similarity: Similarity is restricted to zinc cluster in N-terminal part of protein.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae
An15g04750	Similarity: partial similarity results from repetitive sequences.; Title: weak similarity to EH domain binding protein h-NUMB-R from patent WO9846744-A1 - Homo sapiens
An15g04760	Catalytic activity: glucan endo-1,3-alpha-glucosidase catalyzes the conversion of endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.; Function: P. purporogenum mutA is a mutanase (glucan endo-1,3-alpha-glucosidase) involved in polysaccharid catabolism.; Title: similarity to mutanase mutA - Penicillium purporogenum; See PMID 10636904
An15g04770	Catalytic activity: GAD catalyzes the conversion of glutamic acid to gamma-aminobutyric acid and the plant GAD binds calmodulin which has not been decribed so far.; Function: It might be possible that intracellular Ca2+ signals via calmodulin are involved in the regulation of gamma-aminobutyric acid synthesis in plants.; Similarity: shows a very strong similarity to undescribed GAD from A. oryzae.; Title: strong similarity to calmodulin-binding glutamate decarboxylase GAD - Petunia hybrida
An15g04780	Function: this family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.; Similarity: belongs to the aldo/keto reductase family.; Title: strong similarity to protein fragment SEQ ID NO:37791 from patent EP1033405-A2 - Arabidopsis thaliana
An15g04790	Function: might be involved in transcriptional regulation.; Similarity: shows partial similarity to protein containing fungal Zn(2)-Cys(6) binuclear cluster.; Title: weak similarity to LEU3 from patent WO8806593-A - Saccharomyces cerevisiae
An15g04800	Catalytic activity: B2Tom hydrolysis of beta-1,2-glucose residue from tetrasaccharide moeity of alpha-tomatine.; Function: B2Tom is involved in the detoxification of alpha-tomatine found in Lycopersicon spp.; Similarity: shows strong similarity to corresponding enzymes of G. graminis, B. fuckeliana etc and several patented proteins.; Title: strong similarity to beta-1,2-D-glucosidase B2Tom - Septoria lycopersici; extracellular/secretion proteins
An15g04810	Catalytic activity: alpha-1,3-mannosyltransferases are responsible for adding the terminal mannose residues of O-linked oligosaccharides.; Title: similarity to alpha-1,3-mannosyltransferase Mnt2 - Saccharomyces cerevisiae; See PMID 10521541
An15g04820	Function: vbs of A. parasiticus catalyzes the step from versiconal hemiacetal to versicolorinB.; Pathway: vbs of A. parasiticus catalyzes a step in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 10855719
An15g04830	Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450
An15g04850	Remark: the Pho85P gene of S. cerevisiae is also called YPL110c or LPH16, but is not identical to Pho85.; Similarity: the predicted ORF is 115 amino acids shorter at the N-terminus than Pho85P of S. cerevisiae.; Title: strong similarity to hypothetical cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae
An15g04860	Catalytic activity: UGT51C1 of C. albicans conbverts UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Function: UDP-glucose:sterol glucosyltransferases synthesize sterol glucosides, typical membrane-bound lipids of many eukaryotes.; Similarity: the ORF shares the strongest homology with the hypothetical protein CHIP6 of G. cingulata.; Title: strong similarity to UDP-glucose:sterol glucosyltransferase UGT51C1 - Candida albicans
An15g04870	Title: similarity to hypothetical protein expressed during hard surface attachment CHIP6 - Glomerella cingulata
An15g04880	Function: annexins are a family of proteins that bind to acidic phospholipids in a calcium-dependent manner.; Function: annexins have been claimed to be involved in cytoskeletal interactions, phospholipase inhibition,intracellular signalling, anticoagulation, membrane fusion and exocytosis.; Remark: anx7 of H. sapiens is also called ANXA7 or synexin.; Similarity: the ORF show strong similarity to different annexin forms from several species.; Title: strong similarity to annexin 7 anx7 - Homo sapiens
An15g04900	Function: endoglucanases hydrolyse internal 1,4-beta-D-glucosidic linkages in cellulose.; Similarity: the ORF shows similarity with some exoglucanases (EC 3. 2. 1. 91) from different species.; Title: strong similarity to endoglucanase IV egl4 -Trichoderma reesei
An15g04920	Title: similarity to hypothetical protein encoded by An04g06270 - Aspergillus niger
An15g04930	Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Similarity: the predicted ORF 196 amino acids shorter at the N-terminus and 180 amino acids at the C-terminal end than tol of N. crassa.; Title: strong similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9927450; See PMID 9449795
An15g04940	Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: norA of A. parasiticus is genomically localized within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conductive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: the ORF shows also strong similarity to several aryl-alcohol dehyrogenases from different species.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus
An15g04950	Title: weak similarity to hypothetical protein B11H24.070 - Neurospora crassa
An15g04960	Title: weak similarity to hypothetical protein CAF32133.1 - Aspergillus fumigatus
An15g04970	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 135 amino acids long.; Title: questionable ORF
An15g04980	Title: strong similarity to hypothetical protein encoded by An18g00860 - Aspergillus niger
An15g04990	Remark: the EST an_2920 of A. niger has database entry code EMBLEST:BE759970.; Remark: the sequence of EST an_2920 of A. niger contains several undefinied bases (n).; Title: similarity to EST an_2920 - Aspergillus niger
An15g05000	Remark: the intron-exon structure of the predicted ORF is not common to A. niger proteins.
An15g05030	Function: EstA from S. chrysomallus specifically hydrolyzes short-chain p-nitrophenyl esters.; Remark: formation of EstA from S. chrysomallus starts at the end of growth phase, and its activity level remains constant throughout stationary phase.; Title: strong similarity to esterase A gene EstA -Streptomyces chrysomallus; See PMID 9829953; See PMID 1474897
An15g05050	Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An15g05060	Function: CFP from C. kikuchii is required for wild type cercosporin production, resistance and virulence on soybean.; Remark: cercosporin is a photoactivated perylenequinone toxin that belongs to a family of photosensitizers which absorb light energy and produce extremely cytotoxic, reactive oxygen species.; Similarity: to multidrug resistance transporter proteins of the major facilitator superfamily.; Title: strong similarity to protein involved in cercosporin production CFP - Cercospora kikuchii; See PMID 10517030
An15g05070	Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Phenotype: when Cyp3a-13 cDNA from M. musculus was expressed in CR119 cells which had been established as a cell line stably expressing NADPH-cytochrome P-450 reductase cDNA of guinea pigs, aflatoxin B1-dependent cytotoxicity was observed.; Title: similarity to cytochrome P-450 protein Cyp3a-13 - Mus musculus; See PMID 7803471
An15g05080	Title: weak similarity to hypothetical protein CAD21084.1 - Neurospora crassa
An15g05090	Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Remark: polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619
An15g05100	Induction: expression of S. cerevisiae UPC2 is induced both in anaerobic and cold-shocked cells.; Phenotype: upc2 null mutant of S. cerevisiae does not show the calcium ion sensitivity and sterol uptake seen in upc2-1 mutants.; Phenotype: upc2-1 mutants of S. cerevisiae show a pleiotrophic phenotype including aerobic accumulation of sterols, total lipid storage, sensitivity to metabolic inhibitors, response to altered sterol structures, and cation requirements.; Remark: synonyms for Upc2 from S. cerevisiae are Mox4 and YDR213w.; Similarity: Upc2 from S. cerevisiae belongs to a fungal regulatory familiy containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; nucleus; See PMID 9696767; See PMID 10073572; See PMID 11292809
An15g05110	Function: gibberlin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641
An15g05120	Function: Ypc1 from S. cerevisiae also has reverse activity, catalyzing synthesis of phytoceramide from palmitic acid and phytosphingosine.; Function: Ypc1 from S. cerevisiae encodes a alkaline ceramidase with reverse (CoA-independent) activity.; Function: Ypc1 from S. cerevisiae encodes an alkaline ceramidase activity responsible for the breakdown of dihydroceramide and phytoceramide but not unsaturated ceramide.; Remark: Ceramide is a core intermediate of sphingolipids, an important modulator of many cellular events including apoptosis, cell cycle arrest, senescence,differentiation, and stress responses.; Remark: the synonym for Ypc1 from S. cerevisiae is YBR183W; Title: similarity to alkaline ceramidase Ypc1 -Saccharomyces cerevisiae; See PMID 10702247; See PMID 10900202
An15g05130	Catalytic activity: phenol sulfate + H(2)O <=> phenol + sulfate.; Function: ars-1 from N. crassa catalyzes the hydrolysis of Sulfate esters.; Remark: N. crassa ars-1 gene is expressed under conditions of sulfur limitation.; Title: strong similarity to arylsulfatase gene ars-1 - Neurospora crassa; See PMID 2528685
An15g05150	Similarity: the ORF encoded protein shows also weak similarity to other transporter proteins.; Title: similarity to immunogenic protein #19915 from patent WO200181581-A2 - Propionibacterium acnes
An15g05160	Title: weak similarity to ORF 711 from patent WO9957280-A2 - Neisseria meningitidis
An15g05170	Catalytic activity: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.; Cofactor: Pyridoxal-phosphate.; Remark: Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.; Title: strong similarity to cysteine synthase cysK -Methanosarcina thermophila; cytoplasm; See PMID 10930739
An15g05200	Similarity: the ORF encoded protein shows also similarities to other methyltransferases.; Title: weak similarity to O-methyltransferase MdmC -Streptomyces mycarofaciens
An15g05220	Catalytic activity: 5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH.; Function: the dihydrofolate reductase from animals and some microorganisms also slowly reduces folate to 5,6,7, 8-tetrahydrofolate.; Remark: essential step for de novo glycine and purine synthesis.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538
An15g05230	Title: weak similarity to hypothetical protein encoded by mll5172 - Mesorhizobium loti
An15g05240	Title: weak similarity to hypothetical protein B14D6.120 - Neurospora crassa
An15g05250	Induction: human Hep27 is synthesized and accumulated in the nucleus of human hepatoblastoma (HepG2) cells, following growth arrest induced by butyrate treatment.; Remark: an alternative name for human Hep27 is protein D.; Similarity: human Hep27 is a putative member of the short-chain alcohol dehydrogenase enzymes (SCAD) family.; Title: similarity to nuclear protein Hep27 - Homo sapiens; nucleus; See PMID 7556196
An15g05260	Remark: The deletion spectrum at het-6 thus resembles other cases where mitotic deletions occur such as of tumor suppressor genes and of the hprt gene (coding for hypoxanthine-guanine phosphoribosyl-transferase) in humans.; Similarity: to heterokaryon incompatibility proteins.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941
An15g05270	Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: the carboxylesterase ES-4 from R. norvegicus also hydrolyses acetanilide and, distinctively,palmitoyl-CoA.; Function: the carboxylesterase ES-4 from R. norvegicus expressed in COS cells hydrolyses omicron-nitrophenyl acetate and alpha-naphthyl acetate.; Remark: changes in activity and expression of ES-4 from R. norvegicus correlate to thyroxine status in the rat suggesting a physiological regulatory role by this hormone.; Title: strong similarity to carboxylesterase precursor protein ES-4 - Rattus norvegicus; See PMID 10395963; See PMID 8611161
An15g05280	Catalytic activity: the F. oxysporum homolog PVA hydrolyses penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid 6-APA).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum
An15g05290	Function: S. cerevisiae Ybt1p transports bile acids in vitro.; Remark: alternative gene names for the S. cerevisiae homolog YLL048c are YBT1 and BAT1.; Similarity: belongs to the superfamily of ATP binding cassette (ABC) transporter.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae
An15g05310	Function: the S. cerevisiae homolog Upc2p encodes a binucleate zinc cluster protein controlling expression of an anaerobic sterol transport system that is responsible for uptake and intracellular esterification of intracellular cholesterol.; Remark: alternative gene names for UPC2 are MOX4 and YDR213w.; Repression: S. cerevisiae Upc2p is heme-inhibited.; Title: strong similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae
An15g05320	Title: similarity to hypothetical protein DR0703 -Deinococcus radiodurans
An15g05350	Function: S. cerevisiae Crh1p is a putative glycosidases involved in cell wall biogenesis.; Induction: transcription of Crh1p is cell cycle dependent.; Similarity: the S. cerevisiae homolog Crh1p shows similarity with various bacterial beta-glucanases and eukaryotic endotransglycosidases.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; plasma membrane
An15g05360	Title: similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens
An15g05370	Catalytic activity: catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: pgaII encodes the A. niger polygalacturonase (pectinase).; Gene-ID: pgaII;pgx2
An15g05380	Remark: this hypothetical orf is most likely the prepro-region of the following gene identical to A. niger PGII.
An15g05410	Function: belongs to a family of low-molecular-weight HSPs related to stress response and protein folding.; Title: strong similarity to heat-shock protein hsp30 - Aspergillus nidulans
An15g05440	Phenotype: Disruption strains showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Similarity: the ORF encoded protein also shows similarity to other hexose transporters.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; putative frameshift; See PMID 8830679
An15g05450	Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: the carbonyl reductase from Candida magnoliae is also described in patent WO9835025-A1.; Similarity: the ORF encoded protein shows also strong similarity to the functionally less characterized dehydrogenases Sou2 and Sou1 from C. albicans. C. albicans Sou(-) mutants are unable to utilize L-sorbose.; Title: strong similarity to NADPH-dependent carbonyl reductase S1 - Candida magnoliae; See PMID 10945260
An15g05460	Remark: S. cerevisiae cells expressing Tpo1 become resistant to polyamine toxicity,the resistance was overcome by bafilomycin A1, an inhibitor of vacuolar H+-ATPase.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows also similarity to a protein involved in cephalosporin C biosynthesis of patent JP09009966-A.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864
An15g05470	Title: similarity to hypothetical protein BH0305 -Bacillus halodurans
An15g05490	Title: strong similarity to hypothetical protein encoded by An02g01140 - Aspergillus niger
An15g05500	Induction: CFL1 transcription in C. albicans is regulated in response to levels of iron and copper.; Title: similarity to ferric reductase cfl1 - Candida albicans; See PMID 10784045
An15g05510	Induction: CaFTR2 expression was repressed under iron-limited conditions and induced when iron supply was sufficient.; Similarity: CaFTR2 from C. albicans is a high-affinity iron permease; Title: strong similarity to high-affinity iron permease CaFTR2 - Candida albicans; plasma membrane; See PMID 10807578
An15g05520	Cofactor: copper.; Function: fet3 from C. albicans is an essential component of copper-dependent iron transport.; Function: fet3 from C. albicans is an iron transport multicopper ferroxidase required for ferrous iron high affinity uptake.; Phenotype: the fet3 deletion mutant of C. albicans was unable to grow in low-iron medium.; Similarity: fet3 from C. albicans belongs to the multicopper oxidase family (TC 9. A. 10).; Title: strong similarity to iron transport multicopper oxidase Fet3 - Candida albicans; plasma membrane; See PMID 10517594
An15g05530	Function: FLU1 in C. albicans is a multidrug efflux transporter gene of the major facilitator superfamily.; Phenotype: expression of FLU1 in C. albicans mediated not only resistance to fluconazole but also to cycloheximide.; Phenotype: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Phenotype: the disruption of FLU1 in a background of C. albicans mutants with deletions in several multidrug efflux transporter genes, including CDR1, CDR2 and CaMDR1,resulted in enhanced susceptibility to several azole derivatives.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An15g05540	Function: the gene product of the mtr locus of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 1838345
An15g05550	Title: weak similarity to neuronal apoptosis inhibitory protein Naip1 - Mus musculus
An15g05560	Similarity: the ORF encoded protein shows also weak similarities to other proteins, which are based on repetetive structures.; Title: similarity to EST Nig004 - Aspergillus niger
An15g05570	Title: questionable ORF
An15g05580	Function: the fused gene Lux::npt-II with comprises a gene conferring conditional growth advantage and a marker gene, used as a probe to select and isolate genetic elements.; Remark: the matched sequence is that of a fusion protein encoded by the firefly (P. pyralis) luciferase:neomycin phosphotransferase-II chimeric gene.; Title: similarity to Lux/npt-II fusion protein from patent WO9217593-A - synthetic
An15g05590	Title: weak similarity to protein fragment SEQ ID NO:13253 from patent EP1033405-A2 - Arabidopsis thaliana
An15g05600	Title: weak similarity to indole-3-glycerol phosphate synthase - Staphylococcus aureus
An15g05610	Remark: the ORF is truncated and contains no start codon, due to the end of the contig.; Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An15g05630	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: contains 12 WD40-like repeats.; Similarity: the A. niger protein, like het-e1 of P. anserina, contains both a GTP-binding domain and a WD40-repeat domain reminiscent of G-protein alpha and beta subunits, respectively.; Title: similarity to vegetative heterokaryon incompatibility factor het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123
An15g05650	Function: SRPK2 of H. sapiens specifically phosphorylates the SR family of splicing factors involved in spliceosome assembly and alternative splicing regulation.; Title: strong similarity to SR-protein-specific serine kinase SRPK2 - Homo sapiens; See PMID 9472028
An15g05660	Title: questionable ORF
An15g05670	Catalytic activity: N,N-Dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP(+) + H2O.; Title: strong similarity to flavin-containing monooxygenase 1C1 - Oryctolagus cuniculus; See PMID 8486656
An15g05680	Complex: the Sm proteins B', B, D1, D2, D3, E, F and G constitute the core of the spliceosomal ribonucleoprotein particles U1, U2, U4/U6 and U5.; Function: the Sm proteins are necessary for spliceosome assembly.; Function: the Sm proteins interact with the Sm site present in four of the major spliceosomal small nuclear RNAs.; Title: strong similarity to Sm-type small nuclear ribonucleoprotein F - Homo sapiens; nucleus; See PMID 7744013
An15g05690	Similarity: also shows strong similarity to the Aspergillus oryzae EST SEQ ID NO:4834 of the DNA patent WO200056762-A2 (PATENTDNA:AAF12311).; Title: strong similarity to hypothetical conserved protein SPBC2D10.03c - Schizosaccharomyces pombe
An15g05700	Title: similarity to hypothetical protein CAB91732.2 - Neurospora crassa
An15g05710	Catalytic activity: phosphatidic acid (derivative) + H2O = 2-acylphosphoglyceride (derivative) + fatty acid.; Title: strong similarity to hypothetical phosphatidic acid-preferring phospholipase A1 B14D6.220 -Neurospora crassa
An15g05720	Function: gephyrin of R. norvegicus binds with high affinity to molybdopterin, the metabolic precursor of the molybdenum cofactor.; Function: gephyrin of R. norvegicus catalyzes the final step in the biosynthesis of the molybdenum cofactor,the insertion of molybdenum into molybdopterin.; Function: gephyrin of R. norvegicus forms a submembraneous scaffold for anchoring inhibitory neurotransmitter receptors in the postsynaptic membrane to subsynaptic microtubules.; Function: gephyrin of R. norvegicus is able to reconstitute molybdenum cofactor (MoCo) biosynthesis in Moco-deficient bacteria, a molybdenum-dependent mouse cell line, and a Moco-deficient plant mutant.; Function: the molybdenum cofactor biosynthesis enzyme Cnx1 of A. thaliana binds to the cytoskeleton in the same way that its mammalian homolog gephyrin does in neuronal cells.; Similarity: also shows strong similarity to the molybdenum cofactor biosynthesis enzyme Cnx1 of Arabidopsis thaliana.; Title: strong similarity to postsynaptic receptor clustering and molybdenum cofactor biosynthesis protein gephyrin - Rattus norvegicus; See PMID 9990024; See PMID 11325967
An15g05730	Complex: Vma16p of S. cerevisiae forms part of the membrane-embedded multi-subunit V0-complex of vacuolar H(+)-transporting ATPase.; Function: Vma16p of S. cerevisiae is involved in the assembly of the V0V1-complex of vacuolar H(+)-transporting ATPase.; Function: Vma16p of S. cerevisiae is required for H(+)-transport activity of the vacuolar H(+)-transporting ATPase.; Function: vacuolar H(+)-transporting ATPase is required for the acidification of the vacuolar lumen.; Localization: Vma16p of S. cerevisiae is incorporated into the vacuolar membrane.; Remark: an alternative name for VMA16 of S. cerevisiae is PPA1.; Title: strong similarity to vacuolar H(+)-transporting ATPase V0-complex proteolipid subunit c Vma16 - Saccharomyces cerevisiae; vacuole; See PMID 9030535
An15g05740	Function: Rab6 of H. sapiens is probably involved in vesicle traffic targeting.; Similarity: belongs to the ras superfamily.; Title: strong similarity to GTP-binding protein Rab6 - Homo sapiens; See PMID 2501306
An15g05750	Title: similarity to hypothetical protein SPAC26H5.13c - Schizosaccharomyces pombe
An15g05770	Function: four conserved cystein residues in the sulphite reductase domain are required for binding of a 4Fe4S cluster and a siroheme as cofactors.; Function: the protein is likely to incorporate a flavodoxin oxidoreductase (electron donor undetermined), a flavodoxin electron transfer domain and a sulfite reductase catalytic domain.; Similarity: the C-terminus is highly similar to a variety of sulphite reductases.; Similarity: the N-terminus is similar to pyruvate:ferrodoxin/flavodoxin oxidoreductases.; Similarity: the middle domain is homologous to FMN-containing flavodoxins.; Title: strong similarity to hypothetical sulphite reductase SPAC4C5.05c - Schizosaccharomyces pombe
An15g05780	Complex: RPC37 of S. cerevisiae is the RNA Polymerase C (III) 37 kDa subunit and interacts with the C53 subunit.; Function: RNA polymerase III is necessary for the transcription of tRNAs, the 5S rRNA and other small stable RNAs.; Remark: RPC37 of S. cerevisiae is also called YKR025w.; Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: strong similarity to 37 kD subunit of DNA-directed RNA polymerase III Rpc37 - Saccharomyces cerevisiae; nucleus; See PMID 9159472; See PMID 10375630; See PMID 10393904
An15g05790	Regulation: RPO1 of S. cerevisiae is subject to catabolite repression.; Remark: mitochondrial RNA polymerases have also been assigned the role of a primase in the replication of mtDNA.; Similarity: RPO41 of S. cerevisiae and the predicted protein show similarity to bacteriophage-coded RNA polymerases.; Title: strong similarity to mitochondrial DNA-directed RNA polymerase Rpo41 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3308116; See PMID 3517858; See PMID 2152961; See PMID 2677667; See PMID 3045116
An15g05800	Remark: the ORF is classified as questionable because it has no similarity and is located, on the opposite strand, in region corresponding to the 5'-UTR of the following A. niger xylR transcript.; Title: questionable ORF
An15g05810	Function: the transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in A. niger, constituting a key factor allowing A. niger to harmonize its sugar metabolism and extracellular xylan degradation through regulation of gene expression.; Gene-ID: xlnR;xylR; Mapping: xlnR from A. niger is mapped to chromosome III (LG III); see list from DSM, EMBL AJ001909.; nucleus; See PMID 9466262; See PMID 9758775; See PMID 10376490; See PMID 10508057; See PMID 10760176
An15g05820	Similarity: many of the hypothetical proteins showing similarity to the predicted ORF are annotated as pyruvate formate-lyase activating enzyme; the predicted protein shows only a stretch of 31 residues with 41% identity to the first enzymatically characterized pyruvate formate-lyase activating enzyme (of E. coli), then nothing can be concluded about its enzymatic activity or function.; Title: strong similarity to hypothetical conserved protein aq_729 - Aquifex aeolicus
An15g05840	Similarity: the first three exons of the predicted protein correspond to A. niger EST SEQ ID NO:4205 of patent WO200056762-A2.; Title: similarity to hypothetical protein CAC28841.2 - Neurospora crassa
An15g05850	Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: similarity to hypothetical protein AAH08596.1 - Homo sapiens
An15g05860	Similarity: the similarity to F12F6. 5 of C. elegans is due to a very short stretch of quite well conserved amino acids.; Title: weak similarity to hypothetical protein F12F6.5 - Caenorhabditis elegans
An15g05870	Title: weak similarity to hypothetical protein AAH07476.1 - Mus musculus
An15g05880	Title: strong similarity to hypothetical protein SPBC1604.01 - Schizosaccharomyces pombe
An15g05890	Catalytic activity: aldehyde dehydrogenase catalyzes the NAD-dependent conversion of an aldehyde to the corresponding carboxylate.; Similarity: the predicted protein shows similarity to several aldehyde dehydrogenases from different species,and to different isoforms of the enzyme within single organisms; such enzymes show often a variety of different substrate specificities, of subcellular localization and tissue distribution.; Title: strong similarity to aldehyde dehydrogenase AHD-M1 - Mus musculus; See PMID 8058062
An15g05900	Title: questionable ORF
An15g05920	Function: TOA2 from S. cerevisiae is necessary for the basal transcription machinery of RNA polymerase II; by binding to TATA binding protein (TBP) transcription is initiated from the Pol II promoter.; Phenotype: the S. cerevisiae TOA2 null mutant is inviable.; Remark: the systematic name of TOA2 from S. cerevisiae is YKL058W.; Similarity: the ORF overlaps with A. niger EST (PATENTDNA:AAF11372) SEQ ID NO:3895.; Title: strong similarity to small subunit of transcription factor TFIIA Toa2 - Saccharomyces cerevisiae; nucleus; See PMID 10692576
An15g05930	Remark: A. niger EST an_3119 has the database entry number EMBLEST:BE758865.; Similarity: additionally, the ORF overlaps with a short part of A. niger EST (EMBLEST:BE759083) an_3391.; Title: strong similarity to EST an_3119 -Aspergillus niger
An15g05940	Function: in addition to their catalytic role,hexokinases are thought to be involved in triggering carbon catabolite repression.; Phenotype: mutations in the A. nidulans xprF (and xprG) genes have been shown to result in elevated levels of extracellular protease in response to carbon limitation.; Remark: a splice site was detected upstream of the START codon.; Remark: no loss of glucose or fructose phosphorylating activity was detected in A. nidulans xprF1 or xprF2 mutants, which could mean, that (1) the xprF gene may encode a minor hexokinase or (2) the xprF gene may encode a protein with no hexose phosphorylating activity.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759083) an_3391.; Title: strong similarity to hexokinase-like protein xprF - Aspergillus nidulans; See PMID 11102357
An15g05950	Title: questionable ORF
An15g05960	Similarity: the predicted protein shows also weak similarity to a D. melanogaster hypothetical protein with unknown function.; Title: weak similarity to hypothetical protein AAF54945.1 - Drosophila melanogaster
An15g05980	Function: the S. cerevisiae TNA1 transporter is involved in the uptake of nicotinic acid.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: the C-terminal part of the predicted protein shows only weak similarity to TNA1.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10649454; See PMID 10869563; See PMID 10984621
An15g05990	Catalytic activity: D-arabinitol + NAD+ = D-ribulose + NADH.; Catalytic activity: xylitol, D-glucitol and galactitol can also acts as substrates for ARDH of P. stipitis.; Complex: ARDH of P. stipitis is a homotetramer.; Similarity: ARDH of P. stipitis belongs to the short-chain dehydrogenase family; the predicted protein shows similarity also to other members of this family, thus another substrate specificity cannot be excluded.; Title: strong similarity to D-arabinitol 2-dehydrogenase ARDH - Pichia stipitis; See PMID 7483848
An15g06010	Function: human 76p is involved in microtubule nucleation.; Localization: human 76p is located at the centrosome; the similarity is too weak to draw conclusions about the localization of the predicted protein.; Similarity: the similarity to human 76p is limited to the N-terminal part of the predicted protein and shows significant gaps.; Title: similarity to gamma tubulin ring complex protein 76p - Homo sapiens; See PMID 10562286
An15g06020	Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Function: UBA1 of S. cerevisiae activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP; thereafter the ubiquitin is transferred to any of a number of ubiquitin-conjugating E2 enzymes.; Pathway: first step in ubiquitin conjugation.; Title: strong similarity to ubiquitin activating protein Uba1 - Saccharomyces cerevisiae; See PMID 7629121; See PMID 8982460; See PMID 1989885
An15g06030	Function: ECM4 of S. cerevisiae is involved in cell wall biogenesis and architecture.; Remark: ECM4 of S. cerevisiae is also called YKR076w.; Title: strong similarity to hypothetical protein Ecm4 - Saccharomyces cerevisiae; See PMID 9159472; See PMID 9335584
An15g06040	Localization: the rabbit Ca-dependent carrier is mainly located in the peroxisomal membrane, although a minor fraction is found in the mitochondria; the Ca2+ binding N-terminal half of the transporter faces the cytosol.; Similarity: the C-terminal part of these proteins has strong similarity to mitochondrial carrier proteins,that have a variety of substrate specificities and that are involved in energy transfer in the inner mitochondrial membrane.; Similarity: the predicted protein shows strong similarity to the rabbit Ca2+-dependent carrier and to other similar mammalian proteins like human Aralar.; Similarity: these proteins are characterized by the presence, in the N-terminal, of EF-hands that bind calcium and cause conformational changes.; Title: strong similarity to Ca-dependent solute carrier - Oryctolagus cuniculus; See PMID 9238007; See PMID 9722566
An15g06050	Complex: UME3 of S. cerevisiae is a component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation.; Function: activity of the kinase (SSN3)/cyclin (SSN8) pair is required, along with SSN6 & TUP1, for transcriptional repression of specific genes.; Remark: UME3 of S. cerevisiae is also known as GIG3,NUT9, SRB11, SSN8 or YNL025C.; Similarity: UME3 of S. cerevisiae and the predicted ORF show strong similarity to human cyclin C and to H. sapiens cyclin H/S. cerevisiae ccl1, which are decribed to be a companion of cdk7, the cyclin-dependent kinase involved in the phosphorylation of the largest subunit of the RNA polymerase II; both are part of a subcomplex of TFIIH, the transcription initation factor TFIIK.; Title: strong similarity to cyclin homolog Ume3 -Saccharomyces cerevisiae; nucleus; See PMID 7732022; See PMID 8524287; See PMID 9303311; See PMID 9488431; See PMID 9520600
An15g06070	Title: questionable ORF
An15g06080	Title: similarity to hypothetical protein SPAC22H10.02 - Schizosaccharomyces pombe
An15g06100	Title: weak similarity to hypothetical protein B21O8.60 - Neurospora crassa
An15g06110	Function: syntaxins are involved in intracellular vesicle trafficking.; Similarity: the predicted protein shows much stronger similarity to syntaxin 8 related protein of Neurospora crassa, a hypothetical protein.; Title: weak similarity to syntaxin 6 STX6 - Rattus norvegicus; See PMID 8663448
An15g06120	Similarity: mouse TRAF5 is member of the TNF receptor-associated factors family, implicated in signal transduction especially in lymphocytes.; Similarity: the predicted protein shares with TRAF5 many structural and functional domains, implicating a conservation of the signal transduction properties,although in different physiological contexts.; Title: similarity to TRAF5 - Mus musculus; See PMID 9990039; See PMID 10202013; See PMID 10449775; See PMID 10523862; See PMID 11046039
An15g06140	Function: hyphal fusion between N. crassa strains that are of alternative het-C specificity results in vegetative heterokaryons that are aconidial and which show growth inhibition and hyphal compartmentation and death.; Function: in Neurospora crassa, 11 het loci have been identified that affect the viability of vegetative heterokaryons; the het-C locus has at least three mutually incompatible alleles, termed het-c(OR), het-c(PA), and het-c(GR).; Function: in filamentous fungi, nonself recognition during vegetative growth is believed to be mediated by genetic differences at heterokaryon incompatibility (het) loci.; Title: strong similarity to heterokaryon incompatibility protein HET-C - Neurospora crassa; See PMID 8001163; See PMID 8088519; See PMID 8844148; See PMID 9258675; See PMID 124288
An15g06150	Title: strong similarity to hypothetical protein EAA64210.1 - Aspergillus nidulans
An15g06160	Similarity: the predicted ORF shows similarity to different known or hypothetical methyltransferases with different specificity.; Title: similarity to gamma-tocopherol methyltransferase gamma-TMT from patent WO9904622-A1 -Synechocystis sp.
An15g06180	Remark: the ORF is also called SPAC22H10. 03c.; Title: strong similarity to hypothetical protein ranbp7p - Schizosaccharomyces pombe
An15g06190	Complex: the 'Spindle Checkpoint Complex' is composed of Mad1, Mad2 and Mad3. It interacts with Cdc20.; Function: the S. cerevisiae Mad2 protein is involved in the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.; Remark: alternate name for S. cerevisiae Mad2: YJL030W.; Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST v7h04a1. f1.; Title: similarity to spindle checkpoint protein Mad2 - Saccharomyces cerevisiae; nucleus; See PMID 10366450; See PMID 10837255
An15g06200	Title: similarity to transcriptional regulator molecule HTRM clone 693452 from patent WO9957144-A2 - Homo sapiens
An15g06210	Similarity: the ORF encoded protein closer related to hypothetical protein YGR111w from S. cerevisiae.; Title: weak similarity to alpha-2 subunit of propyl-4-hydrolase from patent WO9738121-A1 - Mus sp.
An15g06220	Title: weak similarity to hypothetical replicase ORF-I - Garlic virus C
An15g06230	Function: the S. cerevisiae Anp1 protein involved in the organization of the secretory pathway. It required to maintain a functional Golgi-apparatus.; Golgi; Remark: alternate names for S. cerevisiae Anp1: Gem3, Mnn8 or YEL036C.; Similarity: the S. cerevisiae Anp1 belongs to the Anp1 / Mmn9 / Van1 family.; Title: strong similarity to aminonitrophenyl propanediol resistance protein Anp1 - Saccharomyces cerevisiae; See PMID 7957057; See PMID 9434768; See PMID 10635561
An15g06240	Catalytic activity: chlorophyllide A + NADP(+) <=> protochlorophyllide + NADPH.; Function: the PorB protein from Hordeum vulgare is involved in the phototransformation of protochlorophyllide (pchlide) to chlorophyllide (chlide).; Similarity: the ORF DNA sequence shows strong similarity to the Aspergillus niger EST an_2781. The ORF encoded protein is also similar to the protein from patent WO9423043-A, which is functionally not clearly enough described.; Title: similarity to NADPH-protochlorophyllide oxidoreductase PorB - Hordeum vulgare; See PMID 7724548
An15g06250	Catalytic activity: (R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + NADH.; Title: strong similarity to 2,3-butanediol dehydrogenase ADH - Pseudomonas putida; See PMID 7813883
An15g06260	Function: the S. cerevisiae Arc1 protein binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets). It binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.; Remark: alternate names for S. cerevisiae Arc1: G4P1 or YGL105W.; Title: strong similarity to GU4 nucleic-binding protein 1 Arc1 - Saccharomyces cerevisiae; See PMID 8895587; See PMID 9659920; See PMID 11069915
An15g06270	Similarity: the ORF encoded protein exclusively shows strong similarity to the hypothetical protein B11B22. 120 from Neurospora crassa.; Title: similarity to potassium-dependent sodium-calcium exchanger NCKX1 - Gallus gallus; See PMID 10662833; See PMID 11023899
An15g06280	Function: A. niger Aspergillopepsin I catalyzes the hydrolysis of proteins with a broad specificity. It generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. It does not clot milk.; Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate names for the A. niger Aspergillopepsin I protease: Awamorin, Aspergillopepsin A,Proteinase B, Proctase B, PepA or Aspergillopeptidase A.; Title: strong similarity to aspartic proteinase aspergillopepsin I pepA - Aspergillus niger [truncated ORF]; extracellular/secretion proteins; See PMID 7787314; See PMID 1508158
An15g06290	Function: the B. subtilis MinD ATPase is required for the correct placement of the division site. The cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. It rapidly oscillates between the poles of the cell to destabilize FTSZ filaments that have formed before they mature into polar Z rings.; Similarity: the ORF encoded protein shows strongest similarity to the protein of unknown function Nbp35 from S. cerevisiae. It also shows strong similarity to the protein sequence HTRM clone 1870914 from patent WO9957144-A2,which function is not clearly enough described.; Title: similarity to cell division inhibitor ATPase minD - Bacillus subtilis; See PMID 10411726
An15g06310	Catalytic activity: S-adenosyl-L-methionine + phosphatidylethanolamine <=> S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.; Pathway: S. pombe Cho2 catalyzes the first step in phosphatidylethanolamine methylation pathway.; Title: strong similarity to phosphatidylethanolamine methyltransferase cho2p - Schizosaccharomyces pombe; See PMID 10799484; See PMID 1655700
An15g06320	Remark: the human protein hRrp41p was expressed in yeast and shown to suppress the lethality of genetic depletion of yeast Rrp41p.; Similarity: the ORF DNA sequence very strong similar to the Aspergillus niger EST an_2945.; Title: similarity to exosome component Rrp41 - Homo sapiens; See PMID 11017189; See PMID 11110791
An15g06330	Title: weak similarity to SFV4 non-structural polyprotein from patent WO9210578-A - Semliki forest virus
An15g06340	Title: weak similarity to myosin-IA - Acanthamoeba castellanii
An15g06350	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens
An15g06360	Remark: In Drosophila, glutamyl-prolyl-tRNA synthetase Aats-glupro is a multifunctional synthetase encoded by a unique gene and composed of three domains: the amino- and carboxy-terminal domains catalyze the aminoacylation of glutamic acid and proline tRNA species,respectively, and the central domain is made of 75 amino acids repeated six times amongst which 46 are highly conserved and constitute the repeated motifs.; Similarity: the predited ORF is about 1000 amino acids shorter at the N-terminus than D. melanogaster Aats-glupro.; Title: similarity to multifunctional glutamine-proline--tRNA ligase Aats-glupro - Drosophila melanogaster; See PMID 1756734; See PMID 9063462
An15g06370	Function: TCP1 is proposed to be required for normal development and function of actin and microtubules either through direct or indirect interaction with the major cytoskeletal components.; Localization: TCP1 from S. cerevisiae was localized to the cytoplasm and the cell cortex.; Title: strong similarity to T-complex-type molecular chaperone Tcp1 - Saccharomyces cerevisiae; See PMID 1901944; See PMID 7865875
An15g06380	Function: l(2)dtl encodes a signal transduction protein involved in cell cycle control.; Induction: induction of l(2)dtl is by heat shock.; Title: similarity to lethal(2)denticleless l(2)dtl -Drosophila melanogaster; See PMID 8666267
An15g06390	Function: RRP5 is required for formation of both 18S and 5. 8S rRNA in yeast.; Localization: Nucleolus; Title: strong similarity to ribosomal RNA processing protein Rrp5 - Saccharomyces cerevisiae; nucleus; See PMID 8896463
An15g06400	Title: similarity to hypothetical protein CAD70839.1 - Neurospora crassa
An15g06410	Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae
An15g06420	Title: weak similarity to urease accessory gene ureD - Bacillus sp.
An15g06430	Complex: XSA1 is a subunit of the cohesin complex which plays an essential role in sister chromatid cohesion in Xenopus laevis cell-free extracts.; Similarity: XSA1 belongs to the SA family of mammalian proteins and exhibit similarity to Scc3p, a recently identified component of yeast cohesin.; Title: strong similarity to cohesin subunit XSA1 -Xenopus laevis; See PMID 10931856
An15g06440	Function: Srp1p (importin alpha) functions as the nuclear localization signal (NLS) receptor in S. cerevisiae.; Function: Srp1p of S. cerevisiae has also a role in regulation of protein degradation separate from its well-established role as the NLS receptor.; Function: Srp1p of S. cerevisiae is involved in nuclear import, nuclear structure, chromosome segregation,and cell cycle.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to karyopherin alpha Srp1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 7644471; See PMID 10394916; See PMID 10913188
An15g06450	Title: similarity to hypothetical protein SPAC26H5.06 - Schizosaccharomyces pombe
An15g06460	Title: strong similarity to hypothetical protein CAD21104.1 - Neurospora crassa
An15g06470	Function: the signal-sequence receptor (SSR) has been shown to be a component of the environment which nascent polypeptides meet on passage through the endoplasmic reticulum (ER) membrane.; Remark: shows similarity to other eukaryotic signal sequence receptor alpha chains, but in most cases the C-terminal part differs.; Title: similarity to signal sequence receptor alpha chain - Canis lupus; endoplasmatic reticulum
An15g06480	Remark: the matching TREMBL entry SCCDC31_2 does not contain the sequence of the S. cerevisiae CDC31 but that of YOR258w.; Similarity: shows also strong similarity to hypothetical protein YOR258w of S. cerevisiae.; Title: strong similarity to hypothetical protein SPCC18.09c - Schizosaccharomyces pombe
An15g06490	Function: might be involved in mRNA splicing.; Similarity: shows strong similarity to several hypothetical ATP-dependent helicases.; Title: strong similarity to hypothetical ATP-dependent RNA helicase YLR419w - Saccharomyces cerevisiae; See PMID 11230534
An15g06500	Similarity: shows similarity to several B-type cyclins of different organisms, but onlythe nimE of A. nidulans shows an almost overall similarity.; Title: strong similarity to cyclin B nimE -Aspergillus nidulans; See PMID 9647650; See PMID 9802893; See PMID 10564263; See PMID 10601021; See PMID 11102358
An15g06530	Remark: blastp matches due to glycine-richness of protein.
An15g06540	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein CAC28648.1 - Neurospora crassa
An15g06550	Title: weak similarity to 47 kD subunit of DNA-directed RNA polymerase III Rpc53 - Saccharomyces cerevisiae
An15g06560	Similarity: shows only similarity against the N-terminal part of the A. thaliana ORF.; Title: weak similarity to hypothetical proline-rich protein T20D16.24 - Arabidopsis thaliana
An15g06580	Catalytic activity: uracil phosphoribosyltransferase catalyzes the conversion of UMP + pyrophosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Gene-ID: furA; Pathway: pyrimidine salvage pathway.; Remark: the matching sequence of furA from A. niger (EMBL: AAK08633) was identified by an BLASTX search.
An15g06590	Title: weak similarity to hypothetical mitochondrial H+-transporting ATP synthase protein 6 homolog MURF4 -Leishmania tarentolae
An15g06600	Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Remark: amdA of A. nidulans has only two introns.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An15g06620	Similarity: shows matches to proline-rich proteins.
An15g06630	Similarity: aminoacids 120 to 215 show similarity to AL0 protein of Indian cassava mosaic virus.
An15g06650	Similarity: N-terminal half differs from all homologs, except the N-terminal SH3 domain.; Similarity: shows similarity to several guanine-nucleotide exchange proteins.; Title: similarity to guanine-nucleotide exchange protein Cdc25 - Saccharomyces cerevisiae; See PMID 10747046; See PMID 1667084; See PMID 1668647
An15g06660	Complex: the COP9 signalosome has eight core subunits that are highly conserved between plants and animals; some of the subunits in Arabidopsis are found in forms that are independent of the complex.; Function: mouse JAB1/CSN5 has been implicated in numerous signaling pathways including those that regulate light signaling in plants, larval development in Drosophila, and integrin signaling, cell cycle control, and steroid hormone signaling in a number of systems.; Function: the COP9 signalosome may have both an evolutionary and a physical relationship with both the regulatory lid of the proteasome and eIF3.; Function: the Constitutive Photomorphogenic9 (COP9) complex is a nuclear localized, multisubunit protein complex essential for repression of light-mediated development in Arabidopsis.; Function: the mouse Jun activating binding protein (JAB1) specifically stabilizes complexes of c-Jun or JunD with AP-1 sites, increasing the specificity of target gene activation by AP-1 proteins; JAB1 is also known as COP9 signalosome subunit 5 (CSN5), which is a component of the COP9 signalosome regulatory complex (CSN).; Similarity: shows also strong similarity to Jun coactivator Jab1 of M. musculus and related proteins.; Title: strong similarity to constitutive photomorphogenic COP9 complex chain AJH2 - Arabidopsis thaliana; nucleus; See PMID 10363642; See PMID 11019806; See PMID 11258719
An15g06670	Expression: human PRC1 protein levels are high during S and G2/M and drop dramatically after cells exit mitosis and enter G1.; Function: human PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in vivo CDK substrate.; Function: human PRC1 is involved in cytokinesis.; Localization: PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis.; Similarity: shows also similarity to anaphase spindle elongation protein ASE1 of S. cerevisiae.; Title: strong similarity to protein regulating cytokinesis PRC1 - Homo sapiens
An15g06680	Catalytic activity: glutamate--tRNA ligases catalyze the conversion of ATP + L-glutamate + tRNA(Glu) = AMP + pyrophosphate + L-glutamyl-tRNA(Glu).; Similarity: shows strong similarity to several eukaryotic mitochondrial and prokaryotic glutamate--tRNA ligases.; Title: strong similarity to mitochondrial glutamate--tRNA ligase Mse1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7607232
An15g06690	Function: human HIRIP4 has been shown to be a positive cochaperones of hsc70.; Function: the chaperone function of Hsp70 proteins in these events is regulated by members of the DnaJ-like protein family, which occurs through direct interaction of different Hsp70 and DnaJ-like protein pairs that appear to be specifically adapted to each other.; Function: the folding of proteins and the assembly of protein complexes within subcompartments of the eukaryotic cell is catalysed by different members of the Hsp70 protein family.; Similarity: shows similarity to several other eukaryotic dnaJ related proteins.; Title: strong similarity to dnaJ related protein HIRIP4 - Homo sapiens; See PMID 8016869; See PMID 10816573
An15g06700	Catalytic activity: dihydroxy-acid dehydratase catalyzes the conversion of 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.; Pathway: fourth step in valine and isoleucine biosynthesis.; Title: strong similarity to dihydroxy-acid dehydratase ilvD - Bacillus subtilis; See PMID 1400210
An15g06720	Title: strong similarity to hypothetical conserved protein PA5185 - Pseudomonas aeruginosa
An15g06730	Similarity: patentmatch against protein AC A46560_1 Trembl.; Title: strong similarity to sequence 3 from patent WO9526406 - Eremothecium gossypii
An15g06740	Alternative name: Rp49; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L32 - Drosophila subobscura; cytoplasm; See PMID 6087289
An15g06750	Remark: ankyrins attach integral membrane proteins to cytoskeletal elements; they bind to Na-K Atpase and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Remark: the H. sapiens brain variant ank2 gene might be alternative spliced producing two variants.; Title: similarity to ankyrin Ank2 - Homo sapiens; See PMID 8253844; See PMID 8557748
An15g06760	Title: similarity to D-oliose 4-ketoreductase mtmU -Streptomyces argillaceus; See PMID 8654997; See PMID 9150235; See PMID 10102355
An15g06770	Title: weak similarity to myosin heavy chain II -Acanthamoeba castellanii; See PMID 3040773; See PMID 3944121
An15g06780	Title: similarity to vesicular acetylcholine transporter VAChT - Homo sapiens; plasma membrane; See PMID 8071310; See PMID 9237624; See PMID 9782459; See PMID 7559575
An15g06790	Function: when overexpressed, Sce3 of S. pombe rescues all mutants of cdc11.; Localization: Sce3p of S. pombe is located predominantly in the cytoplasm.; Remark: in S. pombe, the cdc11 gene is required for the initiation of septum formation at the end of mitosis.; Remark: sce3 of S. pombe encodes a putative RNA-binding protein which shows homology to human eIF4B.; Similarity: the predicted A. niger protein shows strong similarity to the suppressor of the septation mutant cdc11 (Sce3) of S. pombe.; Title: strong similarity to suppressor of the septation mutant cdc11 sce3p - Schizosaccharomyces pombe; cytoplasm; See PMID 9254700
An15g06810	Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + 2 ferrocytochrome b5.; Remark: About one third of the S. cerevisiae Mcr1 precursor protein is inserted into the outer mitochondrium membrane whereas the remaining molecules pass through the outer membrane into the inner membrane, are cleaved by inner membrane protease 1, and are released into the intermembrane space.; Remark: The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to cytochrome-b5 reductase Mcr1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8001120; See PMID 9199337
An15g06820	Title: strong similarity to hypothetical protein SPAC3H5.09c - Schizosaccharomyces pombe
An15g06840	Title: strong similarity to hypothetical protein encoded by EAA61711.1 - Aspergillus nidulans
An15g06850	Title: strong similarity to hypothetical protein YBR261c - Saccharomyces cerevisiae
An15g06860	Title: similarity to hypothetical protein encoded by An06g02540 - Aspergillus niger
An15g06870	Title: strong similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger
An15g06880	Title: similarity to hypothetical transcription factor subunit SPBC336.07 - Schizosaccharomyces pombe
An15g06890	Remark: ORF is N-terminal truncated due to contig end. Overlap with contig cmhx. 00.
An15g06900	Remark: ORF 3'truncated due to end of contig.; Remark: ubiquitin-conjugating enzymes (UBCs) selectively target proteins for proteasomal degradation by the covalent attachment of ubiquitin moieties.; Similarity: the M musculus NCUBE1, yeast UBC6 and chicken NCUBE1 constitute a distinct family of UBCs sharing a conserved noncanonical active site sequence and a C-terminal transmembrane domain.; Title: strong similarity to non-canonical ubiquitin conjugating enzyme 1 ncube1 - Mus musculus [truncated ORF]; endoplasmatic reticulum; See PMID 10708578
An15g06910	Remark: the predicted A. niger protein harbours a DHHC region PF01529 (aa 121-185) which is predicted to be a zink finger domain.; Title: similarity to educed expression in colorectal cancer protein rec - Homo sapiens; See PMID 10918388
An15g06920	Title: strong similarity to hypothetical membrane protein CAC18292.2 - Neurospora crassa; plasma membrane
An15g06925	Title: weak similarity to hypothetical protein SPAC23A1.05 - Schizosaccharomyces pombe
An15g06950	Remark: A. niger var. awamori contains multiple copies of a transposable element, Vader.; Remark: the predicted A. niger ORF contains 16 possible sequencing errors leading to stop codons and frame-shifts and therefore likely is a pseudogene.; Remark: this 437-bp element caused a 2-bp duplication (TA) of the target sequence in A. niger var. awamori and A. niger.; Title: strong similarity to hypothetical transposable element Tan1 - Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8625427
An15g06960	Title: weak similarity to hypothetical regulator protein CAB16735.1 - Schizosaccharomyces pombe
An15g06970	Catalytic activity: sterigmatocystin 7-O-methyltransferase of A. parasiticus catalyses the reaction S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 7-O-methylsterigmatocystin.; Pathway: sterigmatocystin 7-O-methyltransferase of A. parasiticus is involved in aflatoxin biosynthesis.; Similarity: the predicted A. niger protein and sterigmatocystin 7-O-methyltransferase of A. parasiticus belong to the superfamily of O-methyltransferases.; Title: strong similarity to methyltransferase B omtB - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913
An15g06980	Similarity: the predicted protein of A. niger shows similarity to hypothetical transcription regulatory proteins with GAL4-type zinc binuclear cluster domains of the yeasts S. pombe and S. cerevisiae.; Title: similarity to hypothetical transcription regulator protein CAD21130.1 - Schizosaccharomyces pombe
An15g06990	Title: similarity to hypothetical membrane protein YGL060w - Saccharomyces cerevisiae
An15g07000	Catalytic activity: phytase catalyses the reaction myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Function: phytase as component of a feed composition for monogastric animals (e. g., pigs, poultry) enhances the nutritional value of plant material without the need for adding additional phosphate to the feed.; Function: the enzyme showed high activity with 4-nitrophenyl phosphate at a pH range of 3 to 5 and with phytic acid at a pH range of 2. 5 to 7. 5.; Function: the gene (phyA) encoding a heat-stable enzyme has been cloned from A. fumigatus and overexpressed in A. niger.; Remark: shows also high similarity to patent EP969089-A1 that describes a consensus protein sequence (included is A. niger).; Title: strong similarity to phytase phyA -Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9143104; See PMID 10679211; See PMID 11195907
An15g07030	Catalytic activity: farnesyltranstransferase (GGPS1) of H. sapiens catalyses the reaction trans-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.; Complex: the human farnesyltranstransferase behaves as an oligomeric molecule with 280 kDa on a gel filtration column.; Function: farnesyltranstransferase (GGPS1) of H. sapiens synthesizes an important precursor of carotenoids and geranylgeranylated proteins such as small G proteins and for the regulation of a nuclear hormone receptor (LXR-RXR).; Remark: some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.; Similarity: the predicted protein of A. niger shows similarity to geranylgeranyl diphosphate synthases, which are officially named farnesyltranstransferases.; Title: strong similarity to geranylgeranyl diphosphate synthase GGPS1 - Homo sapiens; See PMID 10101267
An15g07040	Catalytic activity: phospholipase D (SPO14) of S. cerevisiae catalyses the reaction phosphatidylcholine + H(2)O = choline + phosphatidatephenol.; Function: the SPO14 gene encodes a phospholipase D (PLD) that is essential for meiosis. analysis of two mutant proteins, one with a point mutation that inactivated the PLD activity (Spo14pK--> H) and one with an amino-terminal deletion (Spo14pDeltaN) which doid not affect PLD activity demonstrated that these mutants could not restore meiosis in a spo14 deletion strain.; Localization: Spo14p is initially distributed throughout the cell, becomes concentrated at the spindle pole bodies after the meiosis I division, and at meiosis II localizes to the new spore membrane as it surrounds the nuclei and then expands to encapsulate the associated cytoplasm during the formation of spores.; Pathway: SPO14p of S. cerevisiae is involved in glycerolipid metabolism and phospholipid degradation.; Remark: the catalytically inactive protein also undergoes relocalization during meiosis; however, in the absence of PLD activity, no membrane is formed. in contrast, Spo14pDeltaN does not relocalize properly, indicating that the failure of this protein to complement a spo14 mutant is due to its inability to localize its PLD activity.; Similarity: the predicted A. niger protein shows strong similarity to the superfamily of phospholipase D. similarity is restricted to a domain of approximately 400 amino acids.; Title: strong similarity to phospholipase D Spo14 -Saccharomyces cerevisiae; See PMID 9425156; See PMID 10425393; See PMID 1582554
An15g07050	Catalytic activity: phenol hydroxylase of T. cutaneum catalyses the reaction phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O.; Pathway: phenol hydroxylase of T. cutaneum is involved in phenylalanine metabolism and catabolism of aromates.; Remark: phenol hydroxylase of T. cutaneum is inhibited by excess phenol.; Similarity: the predicted A. niger protein shows particularly strong similarity to fungal phenol hydroxylases, which belong to the FAD-dependent oxidoreductases.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 1429434
An15g07060	Remark: the gene zas1 of S. pombe encodes putative C2H2 zinc finger proteins that may be due to alternative splicing of zas1 hnRNA.; Title: similarity to hypothetical C2H2 zinc finger protein Zas1A - Schizosaccharomyces pombe; See PMID 10718196
An15g07070	Catalytic activity: cyanase of E. coli catalyses the reaction cyanate + bicarbonate = CO(2) + carbamate.; Remark: cyanase of E. coli belongs to the cyanate-inducible cyn operon. the cyn operon comprises approximately 2600 base pairs and includes cynT, cynS, and cynX, which encode cyanate permease, cyanase, and a protein of unknown function, respectively.; Remark: the covalent structure of cyanase is made up of a cynS dimer which is linked by a disulfide bond between the single cystine residue. the native enzyme (Mr 150,000) then appears to be a complex of four or five such subunit dimers.; Remark: the cyn operon of E. coli is located next to the lac operon, and the direction of cynS transcription was opposite that of lac.; Similarity: the predicted A. niger protein is similar to conserved procaryotic and plant cyanases.; Title: strong similarity to cyanate lyase cynS -Escherichia coli; cytoplasm
An15g07080	Remark: CTCF of G. gallus binds to a specific DNA region of the c-myc promoter and is important for chicken c-myc transcription.; Remark: six major nuclear isoforms of CTCF protein are differentially expressed in different chicken cell lines and tissues.; Remark: the DNA-binding domain of CTCF of G. gallus is composed of 11 Zn fingers: 10 are of C2H2 class, and 1 is of C2HC class.; Similarity: the predicted A. niger protein and CTCF of G. gallus shows similarity to zinc- finger transcription factors.; Title: similarity to zinc-finger transcription factor CTCF - Gallus gallus; nucleus; See PMID 8246978
An15g07090	Remark: the predicted A. niger ORF is encoded entirely by the ESTs an_3153 and an_2361 of A. niger.; Title: strong similarity to hypothetical protein encoded by An12g10350 - Aspergillus niger
An15g07110	Catalytic activity: homocysteine S-methyltransferase AtHMT-1 of A. thaliana catalyses the reaction S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.; Cofactor: homocysteine S-methyltransferase AtHMT-1 of A. thaliana may require zinc as a cofactor.; Function: AtHMT-1 of A. thaliana catalyses methyl transfer from S-methylmethionine or S-adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine.; Remark: AtHMT-1 of A. thaliana complements an Escherichia coli yagD mutant, which lacks HMT (SMM:Hcy S-methyltransferase) activity.; Remark: AtHMT-1 of A. thaliana is strongly inhibited by methionine.; Similarity: the predicted A. niger protein belongs to the homocysteine S-methyltransferases.; Title: strong similarity to homocysteine S-methyltransferase AtHMT-1 - Arabidopsis thaliana; See PMID 10747987
An15g07120	Remark: prnB of A. nidulans encodes the major proline transport system and is part of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Remark: the proline utilisation gene cluster of A. nidulans can be repressed efficiently only when both repressing nitrogen and repressing carbon sources are present.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8437566; See PMID 9140969; See PMID 10613888
An15g07130	Similarity: similarity of the predicted A. niger protein and various protein sequences is due to low complexity sequences.; Title: weak similarity to hypothetical protein M01E5.4 - Caenorhabditis elegans
An15g07140	Title: strong similarity to hypothetical protein encoded by An13g01800 - Aspergillus niger
An15g07150	Catalytic activity: DNA polymerase delta of S. pombe catalyses the reaction n deoxynucleoside triphosphate = n pyrophosphate + DNA(n).; Complex: highly purified, active spPol delta of S. pombe was shown to contain at least four distinct subunits,a large catalytic subunit Pol3, and three smaller subunits Cdc1, Cdc27, and Cdm1 with molecular masses of 125, 51, 42, and 19 kDa, respectively.; Function: DNA polymerase delta of S. pombe possesses two enzymatic activities: DNA synthesis (polymerase) and a 3' to 5' exonucleolytic activity that degrades single stranded DNA.; Remark: aphidicolin inhibits DNA polymerase delta of S. pombe, but not DNA polymerase alpha.; Similarity: the predicted protein of A. niger shows strong similarity to the large subunit (delta chain) of DNA- directed DNA polymerases, which belong to the DNA polymerase type-B family.; Title: strong similarity to catalytic subunit of DNA-directed DNA polymerase delta ol3p -Schizosaccharomyces pombe; nucleus; See PMID 10671561; See PMID 1960723
An15g07160	Catalytic activity: pectin lyases catalyse the eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Remark: Aspergillus niger pectin lyases are encoded by a multigene family with five characterized members (pelA, B, C, D, E and F).; Remark: microbial pectin and pectate lyases are virulence factors that degrade the pectic components of the plant cell wall. the homogalacturan backbone of pectin varies in its degree of methylation from the highly methylated and relatively hydrophobic form known as pectin,to the fully demethylated and highly charged form known as pectate. methylated and demethylated regions of pectin are cleaved by pectin lyase and calcium-dependent pectate lyases, respectively. protein engineering of lyases specific for particular patterns of methylation, will yield modified pectins of high value to the food and pharmaceutical industries.; Remark: pectin lyases A and D (formerly known as PLII and PLI, respectively) are the major components of the commercial pectinase preparation Ultrazym.; Title: strong similarity to pectin lyase pelA -Aspergillus niger; See PMID 9195887; See PMID 1934134; See PMID 2225145
An15g07190	Induction: the ZRT1 gene is induced at the transcriptional level by low intracellular concentration of zinc.; Remark: Zrt1p of S. cerevisiae (also known as YGL255W or NRC376) is a high-affinity zinc transport protein.; Remark: the protein sequence of patent WO9745000-A1 (ID-# AAW41170) is identical to Zrt1p of S. cerevisiae,although the description refers to a metal-regulated transporter (MRT) polypeptide of Arabidopsis thaliana and calls the protein ZRT2.; Similarity: the predicted amino acid sequence of Zrt1p of S. cerevisiae is similar to that of Irt1p, a probable Fe(II) transporter from Arabidopsis thaliana.; Title: strong similarity to high-affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8637895; See PMID 9784581; See PMID 9786854; See PMID 10748254
An15g07200	Remark: the nucleotide sequence is highly similar to the 5'-EST BE760062 of Aspergillus niger.; Title: similarity to hypothetical transmembrane protein - Erysiphe pisi
An15g07220	Remark: the mutant upc2 of S. cerevisiae was identified by its impaired aerobic sterol exclusion and its simultanous hypersensitivity to Ca2+.; Similarity: the ORF of A. niger and UPC2 (YDR213W) of S. cerevisiae contain a Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; See PMID 9696767
An15g07230	Remark: the nucleotide sequence of the ORF is found in many highly similar ESTs of A. niger.; Remark: this is the amino acid sequence of the rat thioredoxin 2 (TrX2), used in the method of the invention in protein repair. Trx2 proteins are translocated to mitochondria and are resistant to oxidation. mitochondria are the sites of vital cellular functions such as lipid metabolism and aerobic respiration (oxidative phosphorylation). in respiration, incomplete reduction of dioxygen results in the formation of reactive oxygen intermediates (ROIs) (hydrogen peroxide, the superoxide anion O2, and the hydroxyl radical OH). increased levels of ROIs, referred to as oxidative stress, can result in lipid peroxidation, inactivation of proteins and strand breakage in DNA. Thioredoxin can act as an antioxidant molecule and scavenge hydroxyl radicals, reduce hydrogen peroxide and reactive proteins inactivated by oxidation. more specifically, Trx2 may be used to protect against ischaemic damage (heart attacks and strokes), eye disease (acts as radio-protectant), radiation and drug toxicity.; Title: similarity to mitochondrial thioredoxin from patent WO9832863-A2 - Rattus sp.
An15g07240	Remark: the DNA sequence (AAT34137) which encodes the biosynthetic enzymes of icosapentaenoic acid (EPA) can be used to transform Escherichia coli. the DNA sequence allows efficient microbial production of EPA, which is a raw material for drugs, agrochemicals, foods and animal feedstuffs. EPA is also useful for lipid balance correction and as an antihypertensive, antiinflammatory and anticancer agent.; Title: strong similarity to icosapentaenoic acid synthase from patent WO9621735-A1 - Shewanella putrefaciens
An15g07250	Function: human ankyrin-1 provides the primary linkage between the membrane skeleton and integral plasma membrane proteins.; Title: similarity to ankyrin B - Homo sapiens; See PMID 10810176
An15g07260	Similarity: the predicted A. niger protein shows strong similarity to several putative microbial and plant oxidoreductases and several patented sequences derived from Arabidopsis thaliana.; Title: strong similarity to hypothetical oxidoreductase PA0147 - Pseudomonas aeruginosa
An15g07270	Expression: CAR1 mRNA levels are low in growing cells, rise to peak expression at 5-10 hr of development when the cAMP signaling system is maximally active, and decrease as development proceeds.; Function: these receptors of D. discoideum coordinate the aggregation of individual cells into a multicellular organism and regulate the expression of a large number of developmentally regulated genes.; Similarity: the predicted protein of A. niger is similar to the multigene family of cell surface cyclic adenosine monophosphate (cAMP) receptors of D. discoideum which includes the chemoattractant receptor CAR1 .; Title: similarity to chemoattractant receptor CAR1 -Dictyostelium discoideum; plasma membrane
An15g07290	Title: weak similarity to hypothetical protein CAB92903.1 - Streptomyces coelicolor
An15g07300	Similarity: the 3' nucleotide sequence of the ORF shows strong similarity to two ESTs of A. niger (the 5'EST an_3564 and the 3'EST an_1208) and the 5'EST r7h08a1. r1 of A. nidulans.; Title: similarity to hypothetical protein encoded by An03g06670 - Aspergillus niger
An15g07310	Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae
An15g07330	Title: similarity to hypothetical protein encoded by 17E5.150 - Neurospora crassa
An15g07340	Catalytic activity: the ezyme 4,5-dihydroxyphthalate decarboxylase of B. cepacia catalyzes the conversion of 4,5-dihydroxyphthalate to 3,4-dihydroxybenzoate and carbon dioxide.; Remark: 4,5-dihydroxyphthalate decarboxylase of B. cepacia participates in the aerobic phthalate degradation pathway.; Remark: the genes for phthalate degradation are arranged in at least three transcriptional units in B. cepacia. the gene for phthalate dioxygenase reductase (ophA1) is present by itself, while the genes for an inactive transporter (ophD) and 4,5-dihydroxyphthalate decarboxylase (ophC) are linked and the genes for phthalate dioxygenase oxygenase (ophA2) and cis-phthalate dihydrodiol dehydrogenase (ophB) are linked.; Title: strong similarity to 4,5-dihydroxyphthalate decarboxylase ophC - Burkholderia cepacia; See PMID 9851995
An15g07350	Title: strong similarity to hypothetical protein CAC28841.2 - Neurospora crassa
An15g07360	Function: the protein PRG3 is a flavin-oxidase that increases the intracellular content of reactive oxygen species (ROS).; Localization: PRG3 is localised in the cytoplasm.; Remark: PRG nucleotides, proteins and antibodies are useful as diagnostic and therapeutic agents for detection and treatment of cancer and other proliferative diseases. the gene/cDNA may be used for gene therapy, to restore a gene function downstream of p53, that cannot be activated in the p53-deficient tumour cell. Antibodies can be used as inducers of cell cycle arrest and/or apoptosis. The DNA sequences can be used to generate 'knockout' animals as a model of cancer susceptibility.; Remark: the patent match is against the translated DNA sequence of patent WO200012526-A1 (AC# AAZ51672).; Remark: the patented sequence is the complete cDNA of PRG3 gene, whose RNA levels are upregulated in response to induction of p53 activity in human colon cancer EB1 cells.; Similarity: the patented DNA sequence encodes the human homolog of Drosophila melanogaster peroxidasin and shares a motif with bacterial flavin-oxidases.; Title: strong similarity to PRG3 protein from patent WO200012526-A1 - Homo sapiens; cytoplasm; See PMID 10441517
An15g07370	Similarity: similarity to the ORF CG4090 of D. melanogaster is due to a repeated sequence motif.; Title: similarity to hypothetical protein encoded by CG4090 - Drosophila melanogaster
An15g07390	Catalytic activity: GPD1 of S. cerevisiae catalyzes the reaction: sn-glycerol 3-phosphate + NAD(+) <=> glycerone phosphate + NADH.; Catalytic activity: glycerol-3-phosphate dehydrogenase (G3PDH) of S. cerevisiae catalyzes the reaction sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.; Function: as osmotic balance regulates cell fusion during mating in S. cerevisiae, a secondary effect of GDP1 mutations is an impairment of cell fusion.; Function: whereas GDP1 is mainly involved in osmoregulation, GDP2 is required to regulate metabolism under anoxic conditions, when glycerol formation is strictly required as a redox sink for excess cytosolic NADH.; Induction: expression of GPD1 of S. cerevisiae is induced by osmotic stress.; Remark: GPD1 of S. cerevisiae is produced with an N-terminal extension that is removed from the functional enzyme; this extension does not target GDP1 to any organelle.; Similarity: S. cerevisiae has a second glycerol-3-phosphate dehydrogenase called GPD2, which is 69% identical to GPD1.; Similarity: the predicted ORF belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.; Title: strong similarity to glycerol-3-phosphate dehydrogenase (NAD+) precursor Gpd1 - Saccharomyces cerevisiae; cytoplasm
An15g07400	Remark: the ORF has an unusual exon/intron structure for A. niger.
An15g07460	Function: OPT1 of C. albicans was cloned from a C. albicans genomic library through heterologous expression in the S. cerevisiae di-/tripeptide transport mutant PB1X-9B. OPT1 restored oligopeptide transport in the mutant cells,as indicated by growth on the tetrapeptide Lys-Leu-Leu-Gly,sensitivity to toxic tetra- and pentapeptides, and an increase in the initial uptake rate of the radiolabelled tetrapeptide Lys-Leu-Gly-[3H]Leu.; Similarity: OPT1 of C. albicans is not a member of the ABC or PTR membrane transport families.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116
An15g07470	Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Similarity: the entire predicted A. niger protein is similar to the N-terminal region of M. grisea PTH11, which is approximately three times longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An15g07480	Similarity: similarities are due to low complexity sequence.; Title: weak similarity to hypothetical eggshell precursor protein - Schistosoma mansoni; See PMID 2911280
An15g07490	Remark: the 2,4-dichlorophenoxyacetate monooxygenase gene (tfdA) of A. eutrophus is localized on plasmid pJP4 together with five additional genes (tfdB, tfdC, tfdD, tfdE and tfdF). plasmid pJP4 permits its host bacterium, strain JMP134, to degrade and utilize as sole sources of carbon and energy 3-chlorobenzoate and 2,4-dichlorophenoxyacetic acid.; Title: strong similarity to 2,4-dichlorophenoxyacetate monooxygenase tfdA - Alcaligenes eutrophus; See PMID 3036764
An15g07500	Catalytic activity: ribokinase catalyses the reaction ATP + D-ribose = ADP + D-ribose 5-phosphate.; Pathway: ribokinase activates D- ribose for the pentose cycle.; Remark: ribokinase of E. coli has been cloned and purified to homogeneity. protein sequence analyses of peptides generated by cyanogen bromide cleavage and o-iodosobenzoic acid cleavage confirmed the translation initiation site and the reading frame of the DNA sequence. amino acid compositions of native ribokinase and the C-terminal dodecapeptide agree with the predicted amino acid compositions, confirming the accuracy of the DNA sequence and the translation termination site.; Remark: the patent match is against the translated DNA sequence 391 of patent WO0100844-A/391 (AC# AX065265),which covers corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production.; Similarity: the ribokinase of E. coli and the predicted A. niger protein are highly conserved in diverse procaryotic and eucaryotic organisms including H. sapiens.; Title: strong similarity to ribokinase rbsK -Escherichia coli; See PMID 3011794
An15g07510	Function: CaPTR2 of C. albicans is involved in the uptake of small peptides. plasmids encoding CaPTR2 restored peptide transport to peptide transport deficient mutants of S. cerevisiae as determined by uptake of radiolabelled dileucine, growth on dipeptides as sources of required amino acids, and restoration of growth inhibition by toxic peptides.; Remark: CaPTR2 of C. albicans was cloned from a C. albicans genomic library by functional complementation of a peptide transport deficient mutant (strain ptr2-2) of S. cerevisiae.; Remark: the patent match is against the protein sequence of patent WO9525114-A1 (AC# AAR84891). The patent covers the peptide transport protein ATPTR2Ap of Arabidopsis thaliana, which will be used to increase plant resistance to herbicidal peptide(s), preferentially those produced by a plant pathogen.; Similarity: the peptide transport gene (CaPTR2) of C. albicans belongs to the PTR2 family of transporters.; Title: strong similarity to peptide transport gene CaPTR2 - Candida albicans; plasma membrane; See PMID 7773409
An15g07520	Title: similarity to hypothetical protein mlr2143 -Mesorhizobium loti
An15g07530	Function: AM-toxin synthetase (AMT) is a primary determinant of virulence and specificity in the A. alternata apple pathotype/apple interaction.; Remark: Afternaria afternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin,AM-toxin.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An15g07540	Remark: C-terminal truncated ORF due to end of contig.
An15g07550	Function: neutral amino acid permease Mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Remark: the protein sequence of neutral amino acid permease Mtr of N. crassa is covered by patent WO9325663-A (AC# AAR47118). the patented Mtr of N. crassa is intended to be used as a selection marker.; Similarity: the predicted A. niger protein shows strong similarity to neutral amino acid permease Mtr of N. crassa and weak similarity to other amino acid transporters.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345
An15g07560	Title: similarity to hypothetical protein dag11 -Agaricus bisporus
An15g07570	Catalytic activity: arylsulfatase ars-1 of N. crassa catalyses the reaction: a phenol sulfate + H(2)O = a phenol + sulfate.; Remark: arylsulfatase of N. crassa is expressed under conditions of sulfur limitation and is under coordinate control of the cys-3+ and scon+ regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685
An15g07580	Function: fructosyl amine oxygen oxidoreductase of A. fumigatus oxidatively degrades glycated low molecular weight amines and amino acids under formation of hydrogen peroxide and glucosone.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus; See PMID 9013588; See PMID 9139700
An15g07590	Remark: ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate into bacteria.; Similarity: belongs to the allantoate permease family.; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; plasma membrane; See PMID 7592429
An15g07600	Remark: the patent match is against the translated DNA sequence of patent EP1097998-A/6 (AC# AX135967), which covers the tetracycline resistance gene tetA.; Remark: the resistance protein TetA is a tetracycline/metal-proton antiporter located in the cytoplasmic membrane.; Similarity: the ORF shows weak similarity to some tetracycline resistance proteins.; Title: weak similarity to protein tetA from patent EP1097998-A - Corynebacterium glutamicum; See PMID 7826010
An15g07630	Title: strong similarity to hypothetical protein encoded by An12g03510 - Aspergillus niger
An15g07670	Catalytic activity: monophenol monooxygenase of S. glaucescens catalyses the reaction L-tyrosine + L-DOPA + O(2) = L-DOPA + DOPAquinone + H(2)O.; Cofactor: monophenol monooxygenase of S. glaucescens requires copper as a cofactor.; Localization: intracellular and extracellular forms of monophenol monooxygenase of S. glaucescens were found to be indentical in molecular weight (29 000), in copper content (0. 21%), in the 19 amino acids at the amino-terminal end and in the ratio of cresolase to catecholase activity (0,005).; Pathway: monophenol monooxygenase plays a role in the metabolism of tyrosine and riboflavin and in the biosynthesis of flavonoids, stilbene and lignin as well as alkaloids.; Similarity: the predicted A. niger protein shows similarity to monophenol monooxygenase (tyrosinase) from S. glaucescens and many other organisms.; Title: similarity to monophenol monooxygenase tyrosinase - Streptomyces glaucescens; extracellular/secretion proteins; See PMID 3002431; See PMID 6804598; See PMID 1901488
An15g07700	Catalytic activity: aspergillopepsin II of A. niger hydrolyses peptide bonds in proteins, preferentially at Tyr-X, Phe-X, His-X, Asn-X, Asp-X, Gln-X, and Glu-X residues.; Inhibition: aspergillopepsin II of A. niger is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin,diazoacetyl-DL-norleucine methyl ester, and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; Remark: Glu-219 and Asp-123 are deduced to be the catalytic residues of aspergillopepsin II.; Remark: pH titration analysis using small-angle X-ray scattering (SAXS) as well as circular dichroism (CD) and gel filtration indicated that the enzyme was unfolded around a neutral pH with concomitant dissociation of the two chains.; Remark: the protein sequence of aspergillopepsin II precursor of A. niger is covered by patent JP04075586-A (AC# AAR22752). the patented aspergillopepsin II (proctase-A) is used to produce secreted acid protease for digestive enzyme preparations.; Similarity: the predicted A. niger protein shows strong similarity, but not identity, to aspergillopepsin II precursor (acid proteinase A) of A. niger, which is a non-pepsin-type acid proteinase and belongs to peptidase family A4.; Structure: aspergillopepsin II of A. niger has a unique two-chain structure with a 39-residue light (L) chain and a 173-residue heavy (H) chain linked noncovalently. the mature two-chain form is processed from the single peptide chain preproenzyme of 282 residues.; Title: strong similarity to aspergillopepsin II precursor (acid proteinase A) - Aspergillus niger; extracellular/secretion proteins; See PMID 7674918; See PMID 9058983; See PMID 10684617; See PMID 10854444; See PMID 1918060
An15g07710	Title: similarity to hypothetical membrane protein YJR085c - Saccharomyces cerevisiae
An15g07720	Catalytic activity: carboxyphosphonoenolpyruvate mutase of S. hygroscopicus catalyses the reaction 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO(2).; Pathway: carboxyphosphonoenolpyruvate mutase is involved in the synthesis of bialaphos, a potent herbicide isolated from S. hygroscopicus.; Similarity: the predicted A. niger protein shows strong similarity to carboxyphosphonoenolpyruvate mutase of S. hygroscopicus and related sequences from other procaryotic species as well as some fungi and A. thaliana.; Title: strong similarity to carboxyphosphonoenolpyruvate mutase - Streptomyces hygroscopicus; cytoplasm
An15g07730	Catalytic activity: 3-isopropylmalate dehydratase (leu1) of R. niveus catalyses 3-isopropylmalate = 2-isopropylmaleate + H(2)O, but also 2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3-carboxypentanone).; Function: the R. niveus leul gene complements leucine auxotrophy of R. niveus M-37 (leu1-), which is deficient for alpha-IPMI.; Pathway: 3-isopropylmalate dehydratase catalyses the second step in leucine biosynthesis.; Similarity: the predicted A. niger protein shows strong similarity to 3-isopropylmalate dehydratase (leu1) of R. niveus, which belongs to the aconitase/IPM isomerase family.; Title: strong similarity to 3-isopropylmalate dehydratase leu1 - Rhizopus niveus
An15g07740	Function: the Leu3 protein of yeast is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: yeast zinc cluster proteins form a major class of yeast transcriptional regulators. they usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein. Leu3p recognizes CGG triplets, but when oriented in opposite directions, an everted repeat.; Similarity: the predicted A. niger protein shows strong similarity to Leu3p, which belongs to the family of Zn(II)2Cys6 proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402
An15g07760	Catalytic activity: purified manA of D. thermophilum hydrolyses 1,4-beta-D-mannosidic linkages in mannose,mannobiose, and mannotriose.; Pathway: manA of D. thermophilum is involved in fructose and mannose metabolism.; Remark: manA of D. thermophilum is a monomeric enzyme with an optimal temperature and pH for activity of 80 degrees C and 5. 0. in the absence of substrate, the enzyme showed no loss of activity at 80 degrees C over 16 h, while at 90 degrees C the enzyme had a half-life of 5. 4 min.; Similarity: the predicted A. niger protein shows strong similarity to beta-mannanase (manA) of D. thermophilum, which is a single-domain enzyme related to one group of beta-mannanases (glycosyl hydrolase family 26).; Title: strong similarity to beta-mannanase manA -Dictyoglomus thermophilum; extracellular/secretion proteins; See PMID 10525841
An15g07770	Remark: not all of the pregnancy-associated glycoproteins have the conserved active sites of the aspartic proteinase family and, therefore, may not be enzymatically active.; Similarity: the predicted A. niger protein shows weak similarity to pregnancy-associated glycoprotein 2 (PAG2) of S. scrofa, which, together with many other pregnancy-associated glycoproteins of S. scrofa and of ruminant species, belongs to the aspartic proteinase gene family (peptidase family A1).; Title: weak similarity to pregnancy-associated glycoprotein 2 PAG2 - Sus scrofa; See PMID 7669851; See PMID 9509990
An15g07790	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences (serine and threonine).; Title: similarity to hypothetical protein encoded by An11g02730 - Aspergillus niger
An15g07800	Title: strong similarity to precursor of alpha-amylase A - Aspergillus niger; See PMID 2340591
An15g07810	Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe
An15g07830	Title: similarity to hypothetical protein attM -Agrobacterium tumefaciens
An15g07840	Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An15g07860	Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe
An15g07870	Catalytic activity: An alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Cofactor: Zinc or Iron.; Remark: Acts on primary or secondary alcohols or hemiacetals. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.; Title: strong similarity to alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 4578954; See PMID 436831; See PMID 1735726
An15g07880	Title: strong similarity to hypothetical hydroxylase A - Amycolatopsis orientalis
An15g07890	Title: similarity to protein c-fos - Xenopus laevis; See PMID 2632235
An15g07900	Title: strong similarity to cytochrome P450 -Myrothecium roridum; See PMID 9529523
An15g07910	Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An15g07920	Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10381407; See PMID 11378962
An15g07930	Catalytic activity: L-arginine + N NADPH + M O(2) <=> citrulline + nitric oxide + N NADP(+).; Remark: truncated due to contig end.; Title: strong similarity to nitric-oxide synthase -Manduca sexta [truncated ORF]; See PMID 9736646
An02g00010	Remark: the ORF has an unusual exon/intron structure for A. niger.
An02g00020	Remark: the ORF is short in length (91 amino acids).; Similarity: the ORF shows over a stretch of ca. 40 amino acids strong similarity to the N-terminus of several yeast allantoin permeases (ca. 500 amino acids in length).; Title: similarity to hypothetical allantoate permease - Schizosaccharomyces pombe
An02g00030	Function: S. cerevisiae ARO8 is specialised for aromatic amino acid and alpha-aminoadipate transamination.; Phenotype: a double mutant of ARO8 and ARO9 of S. cerevisiae is auxotroph for phenylalanine/tyrosine.; Title: strong similarity to aromatic aminotransferases I Aro8 - Saccharomyces cerevisiae; See PMID 9491082; See PMID 9491083
An02g00040	Function: DAL5 of S. cerevisiae is a component of the allantoate transport system.; Remark: DAL5 of S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614
An02g00050	Function: pnba of B. subtilis hydrolysis several beta-lactam antibiotic pnb esters to the corresponding free acid and pnb alcohol.; Remark: pnba of B. subtilis belongs to the type-B carboxylesterase/lipase family.; Similarity: the ORF overlaps with pnba of B. subtilis N-terminally (up to amino acid 300).; Title: strong similarity to para-nitrobenzyl esterase pnba - Bacillus subtilis; See PMID 7828905
An02g00060	Function: Mst-1 of A. muscaria transports monosaccharids via the plasma membrane.; Induction: Mst-1 of A. muscaria is upregulated by monosaccharids.; Remark: Mst-1 of A. muscaria belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An02g00070	Function: bah of S. hygroscopicus removes the N-acetyl group from bialaphos.; Pathway: bah of S. hygroscopicus catalyzes one of the final steps in the bialaphos biosynthetic pathway.; Remark: bah of S. hygroscopicus belongs to the 'GDXG' family of lipolytic enzymes.; Remark: bialaphos is an antibiotic.; Title: strong similarity to bialaphos acetylhydrolase bah - Streptomyces hygroscopicus; See PMID 2066341; See PMID 8688624
An02g00080	Catalytic activity: flhA of P. denitrificans catalyzes the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH.; Complex: flhA of P. denitrificans forms a tetramer.; Function: flhA of P. denitrificans is is essential for the oxidation of formaldehyde produced during methylotrophic growth.; Pathway: flhA of P. denitrificans is a component of the formaldehyde detoxification pathway.; Phenotype: mutation of flhA of P. denitrificans abolishes the bacterium's ability to grow on methanol,methylamine, or choline, whereas heterotrophic growth remains unaffected.; Title: strong similarity to NAD-GSH-dependent formaldehyde dehydrogenase flhA - Paracoccus denitrificans; deleted EC_number 1.2.1.1; See PMID 7798140
An02g00090	Catalytic activity: prolidase of A. esteraromaticum hydrolyses Xaa-|-Pro dipeptides.; Similarity: the ORF overlaps with the A. niger EST an_2700 in EMBLEST:BE759786 at it's C-terminus.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239
An02g00100	Localization: est of A. calcoaceticus is external to the cytoplasmic membrane.; Phenotype: est mutants of A. calcoaceticus loose the ability to grow on simple triglycerides such as triacetin,but they are still able to grow on acetate.; Remark: A. calcoaceticus is an oil-degrading bacterium.; Remark: est of A. calcoaceticus belongs to the 'gdxg' family of lipolytic enzymes.; Similarity: the ORF is aligned to the est of A. calcoaceticus N-terminally (up to amino acid 236) and the alignement encompasses 3 gaps (with one gap > 20 amino acids).; Title: similarity to esterase est - Acinetobacter calcoaceticus; See PMID 2545531
An02g00110	Title: strong similarity to hypothetical protein encoded by An11g10340 - Aspergillus niger
An02g00130	Remark: the ORF has an unusual exon/intron structure for A. niger with very long introns (> 500 bp).; Title: questionable ORF
An02g00140	Catalytic activity: xynB of B. subtilis hydrolysis 1, 4-beta-D-xylans in removing successive D-xylose residues from the non-reducing termini.; Pathway: xynB of B. subtilis is involved xylan degradation/utilization.; Phenotype: the xynB mutant of B. subtilis is deficient in xylan utilization.; Similarity: the similarity of the ORF to xynB of B. subtilis is restricted to the first 400 amino acids (4/5 of the protein).; Title: strong similarity to xylan 1,4-beta-xylosidase xynB - Bacillus subtilis; See PMID 6413490; See PMID 9649739
An02g00150	Function: pdat9 of N. haematococca detoxifies the phytoalexin pisatin.; Remark: pdat9 of N. haematococca was assigned to a new cytochrome P450 family, CYP57.; Remark: pisatin is an antimicrobial compound produced by pea in response to infection by N. haematococca.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 8208242; See PMID 8755624
An02g00160	Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Title: strong similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529
An02g00170	Function: hyuA of Pseudomonas sp. hydrolyzes hydantoin.; Pathway: stereospecific conversion of DL-5-substituted hydantoins to the corresponding L-amino acids.; Similarity: the ORF overlaps solely N-terminal with the hyuA gene of Pseudomonas sp. (up to amino acid 398 of the ORF).; Title: similarity to hydantoin hydrolase hyuA -Pseudomonas sp.; See PMID 1732229; See PMID 9028051
An02g00180	Function: pho-4 of N. crassa encodes a phosphate transporter.; Remark: pho-4 of N. crassa belongs to the pho-4 family of transporters.; Remark: pho-4 of N. crassa serves presumably as Na(+)-phosphate symporter, because phosphate uptake is stimulated 85-fold by the addition of Na+.; Repression: pho-4 of N. crassa is repressed by phosphate.; Similarity: the ORF overlaps with the A. niger EST an_2869 in EMBLEST:BE759926.; Title: strong similarity to phosphate-repressible phosphate permease pho-4 - Neurospora crassa; See PMID 2531109; See PMID 7732001
An02g00190	Complex: the amdA protein of Rhodococcus forms a homodimer.; Remark: amdA of Rhodococcus belongs to the indoleacetamide hydrolases.; Similarity: the ORF overlaps with amdA only at it's N-terminus (up to amino acid 333).; Similarity: the ORF shows strong similarity to amidases and amidotransferases of various species.; Title: similarity to enantiomer-selective amidase amdA - Rhodococcus sp.; See PMID 1938876
An02g00200	Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces.; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Similarity: the alignment of the ORF with pth11 of M. grisea excludes 88 C-terminal amino acids of the ORF and 111 N-terminal and 235 C-terminal amino acids of pth11.; Title: similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529
An02g00210	Function: mxaA of S. aurantiaca extends the assembled polyketide chain of the myxalamids with alanine.; Pathway: mxaA of S. aurantiaca is involved in myxalamid biosynthesis.; Remark: myxalamids are typical polyketide structures with incorporated amino acids.; Similarity: the ORF shows also similarity to other peptide synthetases.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319
An02g00220	Function: the 17beta-HSD protein of C. lunatus catalyses the reduction of steroids and of nonsteroidal substrates.; Remark: 17beta-HSD of C. lunatus belongs to the short chain alcohol dehydrogenase/reductase family.; Remark: expression studies revealed that 17beta-HSD of C. lunatus is mainly expressed in the stationary phase of growth indicating its possible involvement in secondary metabolism.; Similarity: the ORF shows also strong similarity to oxygenase-reductases but these enzymes have about twice the length of the ORF and overlap with the ORF at their C-terminus.; Title: strong similarity to 17beta-hydroxysteroid dehydrogenase 17beta-HSDcl - Cochliobolus lunatus; See PMID 11165029; See PMID 9895285; See PMID 10624836
An02g00230	Function: Fum9 of G. moniliformis is presumably involved in fumonisin biosynthesis.; Remark: fumonisins are mycotoxins found in infected maize and sorghum.; Title: similarity to hypothetical fumonisin biosynthesis protein FUM9 - Gibberella moniliformis
An02g00240	Induction: GABA of A. nidulans is induced via the intA gene.; Repression: GABA of A. nidulans is subject of ammonium repression mediated by the areA gene.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 375001; See PMID 10320578
An02g00250	Catalytic activity: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.; Pathway: the dra protein of B. subtilis is involved in the nucleotide and deoxyribonucleotide catabolism.; Remark: the dra gene of B. subtilis is part of the dra-nupC-pdp operon.; Repression: the dra-nupC-pdp operon of B. subtilis is subject to glucose repression.; Title: strong similarity to deoxyribose-phosphate aldolase dra - Bacillus subtilis; cytoplasm; See PMID 8550462
An02g00260	Function: acu-15 of N. crassa functions as a positive regulator of acetate induction.; Similarity: the ORF and acu-15 of N. crassa are aligned only at a stretch shorter than 200 amino acids and this alignment does not encompass the Zn2Cys6 DNA-binding domain of acu-15 of N. crassa or the leucine zipper of the ORF.; Similarity: the ORF shows also weak similarity to other (putative) transcription factors.; Similarity: the ORF shows strong similarity to the hypothetical protein encoded by An07g01280 from A. niger.; Title: weak similarity to hypothetical transcription activator protein acu-1 - Neurospora crassa
An02g00270	Induction: it was reported that the mRNA for binA of A. nidulans was induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans
An02g00280	Function: the CefT protein confers resistance to some toxic organic acids, including isovaleric acid and phenylacetic acid.; Remark: 2 possible sequencing errors were corrected by intron insertion: the first putative error is located between exons 2 and 3 (1 bp missing) and the second is located between exons 3 and 4 (1 bp too much).; Similarity: the predicted ORF is about 280 amino acids shorter than several major facilitator protein homologs.; Title: similarity to multidrug resistant protein cefT - Acremonium chrysogenum [putative sequencing error]; See PMID 12172807
An02g00290	Function: putative transcriptional regulator.; Title: strong similarity to hypothetical protein EAA61130.1 - Aspergillus nidulans
An02g00300	Title: similarity to hypothetical protein MDB19 -Arabidopsis thaliana
An02g00310	Remark: AFAR is a protein in rat liver cytosol that reduces aflatoxin B1-dialdehyde.; Similarity: shows similarity to several different oxidoreductases with different specificities.; Title: strong similarity to aflatoxin B1 aldehyde reductase AFAR - Rattus norvegicus; See PMID 8526867; See PMID 9331086
An02g00320	Title: weak similarity to hypothetical biotin activation protein jhp1068 - Helicobacter pylori
An02g00340	Function: the A. oryzae amdS gene encodes an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providing A. oryzae with a source of carbon and nitrogen.; Title: strong similarity to acetamidase amds -Aspergillus oryzae; See PMID 1840550
An02g00350	Function: tannase (tannin acyl hydrolase) is a carboxylic ester hydrolase which hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An02g00370	Title: strong similarity to hypothetical protein encoded by An06g00670 - Aspergillus niger
An02g00390	Remark: PTH11 is a pathogenicity gene predicted to encode a novel transmembrane protein. pth11 mutants are nonpathogenic and it is suggested that the protein is involved in host surface recognition by functioning as an upstream effector of appressorium differentiation.; Similarity: shows similarity to central part of M. grisea PTH11 protein, might be a putative pseudogene.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; See PMID 10521529
An02g00400	Similarity: show similarity to several prokaryotic and eukaryotic GMC oxidoreductases with different specificities.; Title: similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774
An02g00420	Similarity: the ORF shows similarity to several multi-drug transporter.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe
An02g00440	Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538
An02g00450	Remark: 4 possible sequencing errors were predicted by genewise, which were corrected by (mini) intron insertions, at position 55739 (1 bp missing), at position 53016 (1 base missing), at position 52327 (1 bp missing),and at position 51457 (1 bp missing).; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus [putative sequencing error]; See PMID 10334994
An02g00460	Protein sequence is in conflict with the conceptual translation; Title: similarity to hypothetical oxidoreductase ox1 - Claviceps purpurea [putative sequencing error]; putative sequencing error
An02g00470	Localization: PTH11 of M. grisea was localised as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: similarity to transmembrane protein PTH11 -Magnaporthe grisea; See PMID 10521529
An02g00480	Title: questionable ORF
An02g00490	Title: weak similarity to mitochondrial precursor protein import receptor tom70 - Neurospora crassa
An02g00500	Title: strong similarity to hypothetical protein encoded by An07g03540 - Aspergillus niger
An02g00510	Title: weak similarity to hypothetical protein encoded by YDL218w - Saccharomyces cerevisiae
An02g00530	Remark: Rsb1 of S. cerevisiae is predicted to be an integral membrane protein with seven transmembrane-spanning domains.; Remark: Rsb1 overproducing cells showed an ATP-dependen decrease in accumulation of exogenously added sphingosine and dihydrosphingosine because of their increased release.; Title: weak similarity to sphingoid long-chain base resistancy protein Rsb1 - Saccharomyces cerevisiae; See PMID 12034738
An02g00540	Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe; nucleus
An02g00550	Remark: the gibberellin (GA) 20-oxidase encoded by the GA5 gene of Arabidopsis directs GA biosynthesis.; Similarity: shows similarity to several oxidoreductases.; Title: similarity to gibberellin 20-oxidase GA5 -Arabidopsis thaliana; See PMID 7604047; See PMID 10330476
An02g00560	Remark: uapA of A. nidulans is a high-affinity,high-capacity specific xanthine/uric acid transporter; the region including amino acid residues 378-446 in UapA is critical for purine recognition and transport.; Title: strong similarity to uric acid-xanthine permease uapA - Aspergillus nidulans; See PMID 9670000; See PMID 10824738
An02g00570	Function: atrazine chlorocyclohydrolase hydrolytically dechlorinates atrazine to hydroxyatrazine.; Pathway: atrazine chlorocyclohydrolase catalyzes the first step in atrazine degradation pathway.; Title: strong similarity to atrazine chlorocyclohydrolase atzA - Pseudomonas sp.; See PMID 8759853; See PMID 11010866
An02g00580	Function: pyruvate dehydrogenase phosphatase PDPc of B. taurus is a serine/threonine phosphatase removing the serine- or threonine-bound phosphate group from pyruvate dehydrogenase.; Title: similarity to pyruvate dehydrogenase phosphatase PDPc - Bos taurus; See PMID 8396421
An02g00590	Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679
An02g00610	Catalytic activity: beta-galactosidase catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Title: similarity to beta-galactosidase bgaM -Bacillus megaterium; See PMID 10322036
An02g00620	Title: weak similarity to endometrium tumour EST encoded protein 15 from patent DE19817948-A1 - Homo sapiens
An02g00660	Title: similarity to hypothetical protein CAC18275.2 - Neurospora crassa
An02g00670	Catalytic activity: ketopantoate reductase catalyzes the conversion of (r)-pantoate + NADP+ = 2-dehydropantoate + NADPH.; Function: ketopantoate reductase catalyzes the nadph-dependent reduction of ketopantoate into pantoic acid.; Pathway: ketopantoate reductase is involved in the alternative pyrimidine biosynthetic (apb) pathway.; Remark: the encoded protein shows also similarities to ketopantoate reductases from other organisms.; Title: similarity to hypothetical protein encoded by all1319 - Nostoc sp.
An02g00680	Title: weak similarity to hypothetical protein YMR192w - Saccharomyces cerevisiae
An02g00700	Title: strong similarity to hypothetical protein encoded by An02g06510 - Aspergillus niger
An02g00710	Similarity: the ORF encoded protein shows weak similarity to many heat shock proteins.; Title: similarity to hypothetical protein CAE76621.1 - Neurospora crassa
An02g00720	Title: questionable ORF
An02g00730	Function: the Cutinase CutA from Botrytis cinerea catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.; Function: the Cutinase allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection.; Title: similarity to cutinase A gene CutA - Botrytis cinerea; extracellular/secretion proteins; See PMID 9002269
An02g00740	Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Pathway: degradation of nicotine.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516
An02g00750	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An02g00760	Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An02g00770	Title: questionable ORF
An02g00780	Title: strong similarity to hypothetical protein PA2063 - Pseudomonas aeruginosa
An02g00810	Catalytic activity: S-Adenosyl-L-methionine + 6-Demethylsterigmatocystin = S-Adenosyl-L-homocysteine + Sterigmatocystin.; Function: O-Methyltransferase I catalyzes both the conversion of demethylsterigmatocystin to sterigmatocystin and the conversion of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtB of A. parasiticus is also called dmtA.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 8285664; See PMID 10543813
An02g00840	Title: similarity to nonribosomal peptide synthase MxcG - Stigmatella aurantiaca; See PMID 11029592
An02g00850	Remark: putative mixed-linked glucanase but the homologe protein from Neurospora with the similar lenght is not described.; Title: strong similarity to hypothetical mixed-linked glucanase precursor related protein MLG1 -Neurospora crassa
An02g00870	Remark: the pap1+ gene is required for spk1(+)-conferred staurosporine resistance.; Title: similarity to transcription factor ap1p -Schizosaccharomyces pombe; See PMID 1899230; See PMID 10731689
An02g00880	Remark: only the region of the MYND finger domain is found in all proteins.; Title: weak similarity to ubiquitin specific protease 15 UBP15 - Arabidopsis thaliana; See PMID 11115897
An02g00890	Catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.; Pathway: glycine, serine and threonine metabolism; vitamin B6 metabolism.; Remark: the SER1 gene encodes 3-phosphoserine aminotransferase which catalyzes the formation of phosphoserine from 3-phosphohydroxy-pyruvate, which is obtained by oxidation of 3-phosphoglycerate, an intermediate of glycolysis.; Similarity: belongs to class-v of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to phosphoserine transaminase Ser1 - Saccharomyces cerevisiae; See PMID 7553933; See PMID 8017107
An02g00910	Catalytic activity: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH.; Remark: IFRH plays a distinct role in plant antioxidant defense and are possibly involved in NAD(P)/NAD(P)H homeostasis.; Similarity: belongs to the isoflavone reductases.; Title: similarity to 2-hydroxyisoflavone reductase IFRH - Arabidopsis thaliana; See PMID 7592828
An02g00950	Remark: the ORF seems approximately 150 amino acids shorter than the Neurospora homolog.; Title: similarity to hypothetical protein B2A19.90 -Neurospora crassa
An02g00957	Title: weak similarity to the transcription factor Pip2 - Saccharomyces cerevisiae
An02g00960	Remark: a splice site upstream of the START codon was detected.; Similarity: the FrcK protein from Sinorhizobium meliloti shows homology with some kinases.; Title: strong similarity to kinase FrcK -Sinorhizobium meliloti; See PMID 11466273
An02g00970	Title: strong similarity to hypothetical protein 13E11.200 - Neurospora crassa
An02g00980	Remark: radixin is a capping protein for the barbed end of actin filaments and it is proposed to play a role in the association of actin filaments with the plasma membrane.; Similarity: to translation initiation factors eIF-2B but the protein seems approximately 200 aa to long.; Title: weak similarity to cytoskeletal protein radixin - Homo sapiens
An02g00990	Remark: putative amidohydrolase by similarity.; Title: strong similarity to amidohydrolase from patent WO0100843-A - Corynebacterium glutamicum
An02g01000	Function: glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Remark: extracellular excretion of the enzyme was observed in a recombinant strain of B. subtilis.; Remark: strong similarity to GL-7ACA aycylase Bacillus laterosporus J1 patent EP482844-A.; Title: strong similarity to glutaryl 7-ACA acylase precursor GL-7ACA - Bacillus laterosporus; See PMID 1744041
An02g01040	Title: similarity to hypothetical protein EAA71860.1 - Gibberella zeae
An02g01050	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism.; Remark: nahG from Pseudomonas putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 6296054; See PMID 8328809; See PMID 1993181
An02g01060	Title: strong similarity to hypothetical protein encoded by An02g01130 - Aspergillus niger
An02g01070	Title: strong similarity to hypothetical protein encoded by An03g03570 - Aspergillus niger
An02g01080	Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe
An02g01090	Function: the nor-1 ketoreductase from Aspergillus parasiticus may be involved in the dehydration of norsolorinic acid to form averantin.; Pathway: aflatoxin biosynthesis.; Remark: a mutation of nor-1 in Aspergillus parasiticus SU-1 blocks the aflatoxin B1 biosynthesis, and results in the accumulation of norsolorinic acid (NA).; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: belongs to the short-chain alcohol dehydrogenases.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 7993094
An02g01100	Remark: YOR273c (TPO4) is a polyamine transporter and it was detected on the vacuolar membrane. Cells overexpressing these gene were resistant to polyamine toxicity and showed an increase in polyamine uptake activity and polyamine content in vacuoles.; Remark: alternative name is YOR273c.; Similarity: belongs to the benomyl/methotrexate resistance protein family.; Title: strong similarity to polyamine transport protein Tpo4 - Saccharomyces cerevisiae; See PMID 11171066; See PMID 9593122
An02g01110	Remark: AiiA Bacillus sp., is an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.; Title: similarity to metallohydrolase aiiA -Bacillus sp.; See PMID 10716724
An02g01120	Title: weak similarity to hypothetical protein encoded by An18g01500 - Aspergillus niger
An02g01130	Title: strong similarity to hypothetical protein encoded by An13g03430 - Aspergillus niger
An02g01140	Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: weak similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408
An02g01160	Title: strong similarity to hypothetical protein encoded by An15g02710 - Aspergillus niger
An02g01170	Remark: the ORF is short in length (55 amino acids).
An02g01180	Catalytic activity: DPP1 removes the beta phosphate from DGPP (Diacylglycerol pyrophosphate) to form phosphatidate.; Remark: alternative name is YDR284C.; Remark: the DPP1 gene, encoding diacylglycerol pyrophosphate (DGPP) phosphatase from S. cerevisiae, has been identified as a zinc-regulated gene, and it contains a putative zinc-responsive element (UAS(ZRE)) in its promoter.; Similarity: to the PAP2 superfamily.; Title: similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 9452443; See PMID 11139591
An02g01200	Remark: loss of KLPA function redresses unbalanced forces within the spindle caused by mutation in bimC, and KLPA and BIMC kinesin-like proteins play opposing roles in spindle function.; Similarity: to kinesin-related protein KLPA.; Title: strong similarity to kinesin-related protein kLPA - Aspergillus nidulans; See PMID 8416986
An02g01210	Function: CRN1 of S. cerevisiae is involved in microtubuli filament assembly by promoting the rapid barbed-end assembly of actin filaments and cross-linking filaments into bundles and more complex networks.; Remark: coronin and the ORF show sequence similarities to G protein beta subunits (WD40 repeats).; Remark: the systematic name for CRN1 of S. cerevisiae is YLR429W.; Title: strong similarity to coronin Crn1 -Saccharomyces cerevisiae; See PMID 9885246
An02g01220	Function: U1 snRNP 70K mediated the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA.; Similarity: the arginine/asparagine-rich C-terminus of the ORF shows similarity to C-terminal sequences in splicing factors, but not to RNA-binding domains.; Title: strong similarity to U1 snRNP 70K protein -Xenopus laevis
An02g01230	Remark: the predicted ORF contains an relatively long intron.
An02g01240	Function: negative co-factor 2 (NC2) of H. sapiens regulates transcription of the class II genes through binding to TFIID and inhibition of pre-initiation complex formation by interacting with TBP-promoter complexes via heterodimeric histone fold domains.; Similarity: the C-terminal half of the ORF shows similarity to the N-terminal half of NC2 of H. sapiens.; Title: strong similarity to alpha chain of transcription regulator NC2 - Homo sapiens
An02g01250	Title: strong similarity to hypothetical protein encoded by 5E6.080 - Neurospora crassa
An02g01260	Function: het-e mediates vegetative incompatibility in the fungus P. anserina.; Similarity: the similarity of the ORF to het-e of P. anserina does not include the GTP-binding region or WD repeats.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina
An02g01270	Similarity: the aligment is restricted to the inner part of the S. pombe protein and the C-terminus of the predicted ORF.; Title: similarity to hypothetical protein SPAC1783.02c - Schizosaccharomyces pombe
An02g01280	Remark: the predicted ORF is only 35 amino acids long.; Title: questionable ORF
An02g01290	Function: PRR1 of S. cerevisiae is involved in pheromone-induced growth arrest, probably by inhibiting gene transcription in pheromone signaling.; Remark: the systematic name for PRR1 of S. cerevisiae is YKL116C.; Similarity: the ORF shows similarity to several unspecified serine/threonine-specific protein kinases from different species.; Title: strong similarity to protein kinase Prr1 -Saccharomyces cerevisiae; See PMID 11337509
An02g01300	Remark: the predcited ORF contains an relatively long intron.; Title: strong similarity to hypothetical protein encoded by An12g03010 - Aspergillus niger
An02g01310	Title: weak similarity to outer membrane protein A precursor ompA - Shigella dysenteriae
An02g01320	Remark: blast matches are not significant.; Title: weak similarity to hypothetical protein encoded by An03g06340 - Aspergillus niger
An02g01330	Similarity: shows similarity to several hypothetical NADH-dependent flavin oxidoreductases.; Title: similarity to hypothetical nadh-dependent flavin oxidoreductase SPBC23G7.10c - Schizosaccharomyces pombe
An02g01340	Title: strong similarity to hypothetical protein encoded by An16g06660 - Aspergillus niger
An02g01350	Function: human ankyrin is a protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Similarity: human ankyrin is C-terminal 1000 aa longer.; Title: similarity to ankyrin - Homo sapiens; cytoskeleton; See PMID 2137557; See PMID 11018513
An02g01360	Complex: in yeast the preprotein import machinery of the inner membrane (MIM complex) consists of MIM23, MIM17,MIM33 and MIM14.; Function: the yeast MIM complex constitutes a proteinaceous channel that accepts preproteins from the MOM complex, facilitates their reversible transmembrane movement, and mediates unidirectional transport by linkage to the ATP-dependent mt-Hsp70-MIM44 system.; Title: strong similarity to subunit of the mitochondrial inner membrane protein import machinery Mim23 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7600576
An02g01370	Title: strong similarity to hypothetical transmembran protein SPCC1494.07 - Schizosaccharomyces pombe
An02g01380	Similarity: predicted protein has prolin repeats and therefore shows unspecific similarity to various prolin rich proteins.
An02g01390	Title: strong similarity to hypothetical protein SPBC14F5.11c - Schizosaccharomyces pombe
An02g01400	Function: ABN A from A. niger endohydrolyses 1,5-alpha-L-arabinofuranosidic linkages in 1,5-arabinanse; Similarity: predicted protein is C-terminal 80 aa longer than all homologies, but no later Startcodon was found.; Title: similarity to endo-alpha-1,5-arabinanase abnA - Aspergillus niger; See PMID 7764386
An02g01410	Similarity: shows unspecific similarity to proteins with serine repeats.
An02g01420	Catalytic activity: mouse unp converts ubiquitin c-terminal thiolester + h(2)o = ubiquitin + a thiol.; Function: the M. musculus homolog Unp is a de-ubiquitinating enzyme,being able to cleave ubiquitin from both natural and engineered linear ubiquitin-protein fusions, including the polyubiquitin precursor.; Similarity: all similar proteins are at least 500 aa shorter.; Title: similarity to ubiquitin specific protease Unp - Mus musculus; See PMID 9602026; See PMID 11018721
An02g01430	Function: AWI 31 form A. thaliana is induced upon wounding.; Title: similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278
An02g01460	Title: questionable ORF
An02g01470	Similarity: shows weak similarity to several DNA-binding zinc-finger proteins due to serine and glutamic acid repeats.; Title: weak similarity to C2H2 zinc finger transcription factor D-Sp1 - Drosophila melanogaster
An02g01480	Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 10943556; See PMID 11065353
An02g01490	Catalytic activity: human Pcd converts (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin <=> (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pter in + H(2)O.; Function: the human Pcd/dimerization cofactor for the transcription factor HNF-1 alpha is a bifunctional protein proposed to be involved in entirely different biochemical functions.; Title: weak similarity to pterin-4-alpha-carbinolamine dehydratase Pcd - Homo sapiens; See PMID 7763270
An02g01500	Similarity: shows unspecific similarity to maize extensin and murin mucin due to serine and proline repeats.; Title: similarity to hypothetical protein B2E7.150 -Neurospora crassa
An02g01510	Complex: Sec62p from S. cerevisiea is part of the oligomeric Sec-protein complex in the endoplasmic reticulum membrane.; Function: Sec62p from S. cerevisiea is an essential component of the Sec-complex that is responsible for posttranslational protein translocation across the membrane of the endoplasmic reticulum.; Remark: Sec62p from S. cerevisiea binds via its cytosolic N- and C-terminal domains to the Sec-complex.; Title: strong similarity to component of the endoplasmic reticulum protein translocation machinery Sec62 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 11071912
An02g01520	Similarity: the weakly similar glucan 1,4-alpha-glucosidase from S. cerevisiae is classified as EC 3. 2. 1. 3.; Title: strong similarity to hypothetical protein YHR151c - Saccharomyces cerevisiae
An02g01530	Remark: the ORF is shorter than the replicase protein of Turnip yellow mosaic virus (713 compared to 1844 amino acids), the alignment between the two proteins encompasses only about 150 amino acids.; Title: similarity to hypothetical replicase protein - Turnip yellow mosaic virus; See PMID 2800335
An02g01540	Function: human ferrodoxin-NADP+ oxidoreductase is a flavoprotein mediating electron transport to all mitochondrial forms of cytochrome P450.; Function: plant ferredoxin-NADP+ (oxido)reductase catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin.; Remark: in mammals Adrenodoxin reductase is synonymous for FNR.; Title: strong similarity to ferredoxin-NADP+ reductase FNR - Homo sapiens; localisation:mitochondrion; See PMID 2236061; See PMID 9039955; See PMID 10899784
An02g01550	Function: CS-Ag from C. immitis is a heat-stable,19-kDa antigen with serine protease activity.; Title: strong similarity to secreted serine protease 19 kDa CS antigen CS-Ag - Coccidioides immitis; See PMID 7558310
An02g01560	Function: human Edg-4 is a functional G protein-coupled receptor for lysophosphatidic acid (LPA).; Title: weak similarity to G protein-coupled receptor Edg-4 - Homo sapiens; See PMID 9525886
An02g01570	Remark: N-terminal 300 aa longer than most similar predicted ORFs.; Title: strong similarity to hypothetical protein B1D1.130 - Neurospora crassa
An02g01580	Function: SNAP proteins activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF.; Function: SNAP proteins play an essential role in membrane trafficking in eukaryotic cells.; Similarity: SEC17 from P. pastoris belongs to the SNAP protein family.; Title: strong similarity to vesicular transport protein SEC17 - Pichia pastoris; intracellular transport vesicles; See PMID 9693958; See PMID 10445030; See PMID 10923020
An02g01590	Similarity: the predicted A. niger protein shows strong similarity to conserved hypothetical proteins from diverse eucaryotic species. conservation of the protein sequences among fungal species is particularily strong.; Title: strong similarity to hypothetical protein B5O22.240 - Neurospora crassa
An02g01600	Title: strong similarity to hypothetical protein B5O22.250 - Neurospora crassa; See PMID 9545376
An02g01610	Catalytic activity: Klebsiella aerogenes UreG is a GTPase.; Complex: in Klebsiella aerogenes UreG forms a complex containing urease apoprotein and the UreD, and UreF accessory proteins.; Function: Eu3 from G. max is necessary for accumulation of the embryo-specific urease Eu1, perhaps by stabilizing it by Ni insertion and activation of the tissue-ubiquitous urease Eu4.; Remark: Eu3 is synonymous to UreG.; Title: strong similarity to nickel-binding urease accessory protein Eu3 - Glycine max; See PMID 10500143; See PMID 10652150
An02g01620	Remark: the matching protein ptaB from Aspergillus nidulans is probably involved in regulation of transcription.; Similarity: shows unspecific similarity to several glutamine rich proteins.; Title: similarity to ptaB - Aspergillus nidulans; See PMID 11309119
An02g01630	Function: AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts.; Function: AAA proteases combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system.; Function: inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans.; Title: similarity to spastin protein Spast - Homo sapiens; See PMID 10610178; See PMID 10782097
An02g01640	Title: strong similarity to hypothetical protein EAA58646.1 - Aspergillus nidulans
An02g01650	Title: strong similarity to hypothetical protein B8B20.20 - Neurospora crassa
An02g01660	Title: weak similarity to hypothetical AP2 domain transcription factor-like protein MPE11.5 - Arabidopsis thaliana
An02g01680	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An02g01690	Complex: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex, and the protein Sar1.; Function: Sec31 is the 150 kDa component of the COPII coat, that covers ER-derived vesicles involved in transport from the Endoplasmic Reticulum to the Golgi Apparatus.; Remark: alternate names for S. cerevisiae Sec31: Web1 or YDL195W.; Title: strong similarity to p150 component of the COPII coat of secretory pathway vesicles Sec31 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11210564; See PMID 9190202
An02g01700	Similarity: the similarity of the ORF encoded protein to the human RNA binding cyclophilin-33B only concerns the RNA binding domain, there are no similarities to the peptidylprolyl isomerase part of CYP-33.; Title: similarity to RNA binding cyclophilin-33B CYP-33 - Homo sapiens; See PMID 8977107
An02g01710	Remark: the ORF is truncated due to the border of contig.; Title: weak similarity to hypothetical protein CAD70407.1 - Neurospora crassa [truncated ORF]
An02g01720	Catalytic activity: 4 ferrocytochrome c + O(2) <=> 4 ferricytochrome c + 2 H(2)O (catalyzed by the complete complex).; Function: the S. cerevisiae Cox12 protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. It is essential during assembly of the cytochrome c oxidase complex for its full activity but apparently can be removed after the oxidase is assembled.; Remark: alternate name for S. cerevisiae Cox12: YLR038C.; Title: strong similarity to subunit VIb of cytochrome c oxidase Cox12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1331057
An02g01730	Function: the S. cerevisiae dicarboxylate transport protein DTP catalyzes an electroneutral exchange across the inner mitochondrial membrane of dicarboxylates (e. g. malonate, malate, succinate) for inorganic phosphate and certain sulfur-containing compounds (e. g. sulfite, sulfate, thiosulfate) (TC 2. A. 29).; Remark: alternate names for S. cerevisiae DTP: DIC1 or YLR348c.; Title: strong similarity to mitochondrial dicarboxylate transport protein Dtp - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9020177
An02g01740	Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Remark: alternate name for S. cerevisiae Msf1: YPR047W.; Remark: in contrast to the cytosolic protein, the mitochondrial phenylalanine--tRNA ligase is active as monomer.; Title: strong similarity to mitochondrial phenylalanine--tRNA ligase alpha subunit Msf1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1924298; See PMID 3029120
An02g01750	Function: S. cerevisiae Mge1 cooperates with mitochondrial Hsp70 (Ssc1) in the mitochondrial import of proteins from the cytoplasm. It seems to control the nucleotide-dependent binding of Ssc1 to substrate proteins and the association of Ssc1 with Mim44.; Localization: S. cerevisiae Mge1 is localized in the mitochondrial matrix.; Remark: alternate names for S. cerevisiae Mge1: Yge1 or YOR232W.; Similarity: S. cerevisiae Mge1 belongs to the GrpE family.; Title: strong similarity to chaperone involved in mitochondrial protein import Mge1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9048947; See PMID 8022808; See PMID 8798629
An02g01760	Complex: CBP1 from Cryptococcus neoformans binds to calcineurin in vitro and in vivo.; Function: Cryptococcus neoformans cbp1 mutant strains exhibit modest defects in growth under stress conditions and virulence.; Remark: Cryptococcus neoformans = Filobasidiella neoformans.; Similarity: the ORF encoded protein shows strongest similarity to the nebula related protein from Neurospora crassa (B5O22. 230) which is functionally not characterized.; Title: similarity to calcineurin-binding protein CBP1 - Cryptococcus neoformans; See PMID 10899116
An02g01770	Catalytic activity: L-arginyl-tRNA + protein <=> tRNA + L-arginyl-protein.; Function: S. cerevisiae Ate1 functions in the N-end rule pathway of protein degradation, where it conjugates Arg, a primary destabilizing residue, to N-termini of proteins bearing secondary destabilizing residues aspartic acid or glutamic acid.; Remark: alternate name for S. cerevisiae Ate1: YGL017W.; Title: strong similarity to arginyl-tRNA-protein transferase Ate1 - Saccharomyces cerevisiae; See PMID 2185248
An02g01790	Function: S. pombe Aps1 catalyzes the hydrolysis of dinucleoside oligophosphates.; Remark: dinucleoside polyphosphates (Ap3A,1 Ap4A,Ap5A, and Ap6A) are involved in intracellular and extracellular signaling functions in several biological systems.; Similarity: S. pombe Aps1 belongs to the nudix hydrolase family.; Title: strong similarity to diadenosine 5,5-P1,P6-hexaphosphate hydrolase aps1p - Schizosaccharomyces pombe; See PMID 10090752; See PMID 10419486
An02g01800	Catalytic activity: N nucleoside triphosphate <=> N diphosphate + {RNA}(N).; Function: S. cerevisiae Rpb3 is a component of the DNA-dependent RNA polymerase II catalyzes the transcription of DNA into mRNA using the four ribonucleoside triphosphates as substrates.; Remark: alternate name for S. cerevisiae Rpb3: YIL021W.; Title: strong similarity to 45 kD subunit of DNA-directed RNA polymerase II Rpb3 - Saccharomyces cerevisiae; nucleus; See PMID 9556554; See PMID 9738888; See PMID 2685562
An02g01810	Title: weak similarity to huntingtin interacting protein 1 related Hip1R - Mus musculus
An02g01820	Title: questionable ORF
An02g01830	Gene-ID: cyc; localisation:mitochondrion; See PMID 2544196
An02g01860	Title: similarity to hypothetical protein CAD21170.1 - Neurospora crassa
An02g01870	Function: the peripheral-type benzodiazepine receptor from mouse is responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. It may play a role in the transport of porphyrins and heme.; Title: strong similarity to peripheral-type benzodiazepine receptor 1 isoquinoline-binding protein MBR - Mus musculus; localisation:mitochondrion; See PMID 8125973
An02g01880	Similarity: the similarities of the ORF encoded protein are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein AAH29548.1 - Mus musculus
An02g01890	Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to hydroxyproline-rich cell wall glycoprotein HRGPnt3 - Nicotiana tabacum
An02g01900	Title: similarity to hypothetical protein SPBP8B7.28c - Schizosaccharomyces pombe
An02g01950	Function: S. cerevisiae Sme1 is an essential for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability.; Remark: alternate name for S. cerevisiae Sme1: YOR159C.; Similarity: the S. cerevisiae Sme1 protein is a human E core protein homolog.; Title: similarity to homolog of the human E core protein Sme1 - Saccharomyces cerevisiae; nucleus; See PMID 8918241; See PMID 9012791
An02g01960	Title: questionable ORF
An02g01970	Title: similarity to hypothetical membrane protein YDL111c - Saccharomyces cerevisiae
An02g01980	Function: DRAP-deaminase of A. gossypii converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.; Pathway: DRAP-deaminase of A. gossypii belongs to the riboflavin biosynthesis pathway.; Remark: the patented gene was isolated from an A. gossypii cDNA library and clones were isolated by functional complementation in S. cerevisiae mutants. it can be used for production of riboflavin in eukaryotic cells.; Title: similarity to DRAP-deaminase rib2 from patent DE4420785-A1 - Ashbya gossypii
An02g01990	Remark: the DnaJ-like protein HSPJ2 of H. sapiens may be used to treat or prevent tissue damage, e. g. in cases of ankylosing spondylitis, heart attack, ischaemia,UV exposure, insulin-dependent diabetes and for wound healing, and may be expressed from a vector containing the nucleic acids. antagonists of HSPJ2 of H. sapiens are used to treat or prevent a wide variety of solid cancers,leukaemia and lymphoma, immune disorders and inflammation.; Title: similarity to DnaJ-like protein HSPJ2 from patent WO9855509-A2 - Homo sapiens; cytoplasm
An02g02000	Remark: the ORF is similar to an EST (AA788334) from A. nidulans.; Similarity: the C-terminus of the ORF is similar to the C-terminus of the hypothetical protein SPAC167. 05 of S. pombe. similarities to other ORFs are due to low complexity of sequence.; Title: strong similarity to hypothetical protein SPAC167.05 - Schizosaccharomyces pombe
An02g02010	Catalytic activity: tyrosyl-tRNA synthetase catalyses ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).; Pathway: the activation of amino acids and transfer to specific tRNA molecules is the first step in protein biosynthesis.; Phenotype: the null mutant of tyrosyl-tRNA synthetase of S. cerevisiae is inviable.; Remark: the tyrosyl-tRNA synthetase gene of S. cerevisiae was isolated by functional complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation.; Similarity: the ORF is similar to tyrosyl-tRNA synthetase.; Title: strong similarity to cytoplasmic tyrosine--tRNA ligase Tyrrs - Saccharomyces cerevisiae; cytoplasm; See PMID 8509419
An02g02020	Function: V-ATPase of S. cerevisiae is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. it is an electrogenic proton pump that generates a proton motive force of 180 mV, inside positive and acidic, in the vacuolar membrane vesicles. V-ATPase catalyses the reaction ATP + H(2)O = ADP + phosphate.; Phenotype: the null mutant of vma-2 of S. cerevisiae is viable, but severely defective for growth in medium buffered at neutral pH.; Remark: the protein vma-2 of S. cerevisiae is a noncatalytic subunit (B) of the peripheral heteromultimeric V1 complex of vacuolar ATPase (V-ATPase).; Title: strong similarity to vacuolar H(+)-transporting ATPase subunit B Vma2 - Saccharomyces cerevisiae; vacuole; See PMID 9819393; See PMID 10358087; See PMID 2478556; See PMID 8626613
An02g02030	Function: isopenicillin N epimerase of N. lactamdurans catalyzes the reversible isomerization between isopenicillin N and penicillin N and requires pyridoxal phosphate as a cofactor.; Pathway: isopenicillin N epimerase is involved in the biosynthesis of cephalosporin antibiotics.; Remark: expression of cefD of N. lactamdurans in S. lividans transformants results in isopenicillin N epimerase activities that are 10-12 times higher than those in N. lactamdurans.; Remark: the sequence SXHKXL in isopenicillin N epimerase of N. lactamdurans resembles the consensus sequence for pyridoxal phosphate binding found in several amino acid decarboxylases from Enterobacteria.; Similarity: isopenicillin N epimerase of N. lactamdurans belongs to class-V of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to isopenicillin N epimerase cefD - Nocardia lactamdurans; cytoplasm; See PMID 1867773
An02g02040	Similarity: the ORF is similar to various long proteins due to low complexity of sequence.; Title: strong similarity to hypothetical protein SPAC4F10.13c - Schizosaccharomyces pombe
An02g02060	Remark: the patented alcohol dehydrogenase is used for the synthesis of coniferyl alcohol, coniferyl aldehyde,ferulic acid, vanillin, vanillic acid and their applications.; Similarity: the protein is similar to alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase from patent EP0845532-A - Unclassified organism; cytoplasm
An02g02070	Similarity: ORF has similarity to several coiled-coil proteins.
An02g02150	Function: Mutations in the developmental modifier medusa (medA) of A. nidulans result in aberrant conidiophores with branching chains of reiterated reproductive cells (metulae), delayed conidial differentiation and frequent reinitiation of secondary conidiophores.; Function: the medusa protein of A. nidulans is required for correct temporal expression of both brlA transcripts (brlA alpha and brlA beta). the medusa protein of A. nidulans is a coactivator required for normal levels of abacus (abaA) expression.; Remark: C-terminus is missing due to truncated ORF.; Title: strong similarity to hypothetical Medusa medA - Aspergillus nidulans [truncated ORF]; See PMID 8722771
An02g02160	Remark: the ORF is highly similar to ESTs BE759272 and BE759284 of A. niger.
An02g02170	Function: tryptophan synthase TRP5 of S. cerevisiae catalyses the reaction L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O. TRP5 also catalyses the conversion of indoleglycerol phosphate into indole and glyceraldehyde phosphate. the enzyme requires the co-factor pyridoxal-phosphate.; Pathway: tryptophan synthase catalyzes the last (fifth) step in the biosynthesis of tryptophan.; Remark: in bacteria and plants, each domain is found on a separate subunit (alpha and beta chains), while in fungi the two domains are fused together on a single multifunctional protein.; Remark: yeast genomic DNA fragments expressed in the yeast shuttle vector pCN60 rescue the trp5 mutation of the yeast cell C9 when they harbor TRP5.; Title: strong similarity to tryptophan synthase Trp5 - Saccharomyces cerevisiae; cytoplasm; See PMID 2675471; See PMID 2734310; See PMID 6276387
An02g02180	Remark: HTRM are human transcriptional regulator molecules. The patent gives no further information about the function of the protein.; Title: similarity to HTRM clone 052927 from patent WO9957144-A2 - Homo sapiens
An02g02190	Function: the protein is a putative transmembrane protein.; Similarity: the protein is similar to patented HRM-7 of H. sapiens and hypothetical proteins from several divergent species.; Title: strong similarity to human regulatory molecule HRM-7 from patent WO9915658-A2 - Homo sapiens
An02g02200	Similarity: the ORF contains repetitive proline and threonine residues.; Title: similarity to hypothetical SNF2/SWI2 protein family member SRCAP - Homo sapiens
An02g02210	Function: HLTF of H. sapiens binds to the B Box of the plasminogen activator inhibitor-1 (PAI-1) gene. in vitro transcription from the PAI-1 promoter in HeLa cell extracts was inhibited by HLTF antibodies and by the HLTF DNA binding domain.; Localization: HLTF from H. sapiens was located in the nucleoplasm and can be immunoprecipitated from HeLa cell nuclear extracts.; Similarity: helicase-like transcription factor (HLTF) from H. sapiens contains a DNA-binding domain, a RING finger domain, and seven helicase domains and is homologous to SWI/SNF proteins of S. cerevisiae.; Title: strong similarity to helicase-like transcription factor - Homo sapiens; nucleus; See PMID 8672239
An02g02230	Similarity: the ORF is strongly similar to hypothetical proteins from several divergent species.; Title: strong similarity to hypothetical protein SPAC824.01 - Schizosaccharomyces pombe
An02g02240	Function: an Asd-4 null mutant of N. crassa obtained by the rip procedure did not show any effect upon nitrogen control, but instead resulted in severe defects in ascus and ascospore genesis.; Function: mobility shift assays demonstrated that ASD4 acts as a sequence-specific DNA binding protein and recognizes DNA fragments that contain GATA core elements.; Remark: ASD4 protein of N. crassa contains a single GATA-type zinc finger and a putative coiled-coil domain. the ASD4 protein exists as a tetramer in solution.; Title: strong similarity to GATA type zinc finger protein ASD4 - Neurospora crassa; nucleus; See PMID 10998244
An02g02250	Function: SRPK2 of H. sapiens is involved in spliceosome assembly for pre-mRNA splicing and the control of trafficking of splicing factors, probably by phosphorylating arginine and serine-rich (RS) domains in respective proteins.; Similarity: the ORF shows similarity to several serine/arginine-rich protein-specific kinases from different species with various cellular fucntions.; Title: strong similarity to serine kinase SRPK2 -Homo sapiens
An02g02260	Title: strong similarity to hypothetical membrane protein YMR155w - Saccharomyces cerevisiae
An02g02270	Title: strong similarity to hypothetical membrane protein YDR105c - Saccharomyces cerevisiae
An02g02280	Function: PMS1 of S. cerevisiae is a mutL homolog and is similar to and associates with Mlh1p, possibly by forming a heterodimer, that binds to a Msh2p-heteroduplex complex containing a G-T mismatch.; Function: PMS1 of S. cerevisiae is required for DNA mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high spore viability, but is dispensable for homologous recombination.; Phenotype: mutations in the DNA mismatch repair protein PMS1 of S. cerevisiae results in elevated rates of spontaneous mutation and causes a marked increase in the instability of simple DNA repeats.; Remark: PMS1 of S. cerevisiae is also called YNL082W or N2317.; Title: strong similarity to DNA mismatch repair gene Pms1 - Saccharomyces cerevisiae; See PMID 8842147; See PMID 7618086
An02g02290	Catalytic activity: delta-1-pyrroline-5-carboxylate dehydrogenases catalyse 1-pyrroline-5-carboxylate + NAD(+) + H(2)O <=> L-glutamate + NADH.; Function: prnC of A. nidulans is involved in the mitochondrial pathway for proline utilization.; Remark: in A. nidulans the genes prnB, prnC, and prnD are clustered.; Repression: prnC of A. nidulans is repressed by the simultaneous presence of glucose and ammonium.; Title: strong similarity to delta-1-pyrroline-5-carboxylate dehydrogenase prnC -Aspergillus nidulans; See PMID 10613888; See PMID 355839
An02g02300	Similarity: the ORF shows weak similarity to peptide synthetases from different species, which are all around 1000 amino acids longer.; Title: weak similarity to nonribosomal peptide synthetase tex1 - Hypocrea virens
An02g02310	Function: the human IBSP product binds tightly to hydroxyapatite. It appears to form an integral part of the mineralized matrix. It probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.; Title: similarity to bone sialoprotein precursor IBSP - Homo sapiens; extracellular/secretion proteins; See PMID 3597437
An02g02320	Remark: alternate name for S. cerevisiae Upc2: YDR213W.; Similarity: the ORF encoded protein and S. cerevisiae are zinc finger transcription factors of the Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 9696767
An02g02330	Function: S. cerevisiae Rta1 is involved in 7-aminocholesterol resistance.; Remark: alternate name for S. cerevisiae Rta1: YGR213C.; Similarity: the ORF encoded protein and S. cerevisiae are also strong similar to yeast RTM1 and YER185w.; Title: strong similarity to hypothetical 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An02g02340	Catalytic activity: UDP-N-acetyl-D-glucosamine + {(1, 4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).; Remark: CsmA=asmA (PIR:JC5546).; Title: strong similarity to chitin synthase with a myosin motor-like domain csmA - Aspergillus nidulans; See PMID 9223429; See PMID 10368147
An02g02360	Catalytic activity: UDP-N-acetyl-D-glucosamine + {(1, 4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).; Remark: C-terminally truncated ORF due to the end of contig.; Remark: CsmA=asmA (PIR:JC5546).; Title: strong similarity to chitin synthase with a myosin motor-like domain csmA - Aspergillus nidulans [truncated ORF]; See PMID 9223429; See PMID 10368147
An02g02370	Function: N. crassa ro-3 is required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. The dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for N. crassa ro-3: p150Glued, Dynactin 150 kDa isoform,DP-150, DAP-150 or 150 kDa Dynein-associated polypeptide.; Title: strong similarity to 150 kDa Dynein-associated polypeptide ro-3 - Neurospora crassa [truncated ORF]; cytoskeleton; See PMID 8744947; See PMID 10878138
An02g02380	Remark: Expression of the SSM1 gene was found to be repressed in the transcription elongation factor S-II null mutant. Ssm1 confers yeast resistance to 6-azauracil.; Remark: alternate names for S. cerevisiae Ssm1: Sdt1 or YGL224c.; Title: strong similarity to hypothetical suppressor of deletion of TFIIS Ssm1 - Saccharomyces cerevisiae; See PMID 10858443
An02g02390	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; nucleus; See PMID 10339552; See PMID 10668804
An02g02400	Remark: N-terminally truncated ORF due to the end of contig.
An02g02410	Induction: HBP undergoes up-regulation in response to cholesterol loading of cells.; Pathway: the 110-kDa membrane protein HBP is a component of a cellular pathway that facilitates removal of excess cholesterol from cells, perhaps through its interaction with HDL.; Remark: HBP preferentially binds HDL apolipoproteins.; Title: similarity to high density lipoprotein-binding protein HBP - Homo sapiens; plasma membrane; See PMID 1318310
An02g02430	Title: weak similarity to G-protein coupled human rhodopsin from patent WO9405695-A1 - Homo sapiens
An02g02480	Function: PT1 has a role in the acquisition of phosphate from the environment.; Induction: PT1 transcript levels increase in response to phosphate starvation.; Induction: PT1 transcripts are present in roots and were not detected in leaves.; Similarity: PT1 shares identity with high-affinity phosphate transporters from Arabidopsis, yeast, Neurospora crassa.; Title: strong similarity to inorganic phosphate transport protein PT1 - Medicago truncatula; plasma membrane; See PMID 9425684
An02g02490	Function: functional rad9 cognates from S. malidevorans can restore radioresistance and the radiation-induced G2 delay response to S. pombe rad9 deletion cells.; Function: rad9p from S. pombe is involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.; Title: similarity to DNA repair protein rad9p -Schizosaccharomyces malidevorans; See PMID 7821792
An02g02510	Catalytic activity: N deoxynucleoside triphosphate = N pyrophosphate + DNA(N).; Function: POL1 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Remark: POL1 cannot initiate a chain de novo but requires a primer which may be DNA or RNA.; Similarity: POL1 belongs to DNA-polymerase type-B family.; Title: strong similarity to polymerase I Pol1 -Saccharomyces cerevisiae; nucleus; See PMID 3047550; See PMID 3287376
An02g02520	Function: thi-4 is believed to be involved in the condensation of pyrimidine and thiazole precursors, which is necessary for the synthesis of thiamine.; Title: strong similarity to thiamin biosynthesis protein thi-4 - Neurospora crassa; See PMID 8662211
An02g02530	Complex: the nucleolar protein fibrillarin interacts with p68.; Function: a role for p68 is either in postmitotic nucleolar reassembly or in the activation of ribosomal DNA transcription/preribosomal RNA processing.; Localization: p68 shows a distinct granular distribution in the nucleus.; Similarity: p68 shows extensive homology with the translation initiation factor eIF-4A.; Similarity: p68 was first identified because of its specific immunological cross-reaction with the DNA tumour virus nuclear oncogene SV40 large T.; Title: strong similarity to ATP-dependent RNA helicase p68 - Homo sapiens; nucleus; See PMID 10837141; See PMID 10648785
An02g02540	Catalytic activity: an acetic ester + H(2)O <=> an alcohol + acetate.; Remark: acetyl esterase I is active on acetylated xylan and mannan.; Remark: acetyl esterase I is used in the preparation of feed or food, and in the paper or pulp industry.; Title: strong similarity to acetyl-esterase I from patent WO9502689-A - Aspergillus aculeatus
An02g02600	Title: strong similarity to hypothetical transcriptional regulator CON7 - Magnaporthe grisea
An02g02620	Remark: C-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein T21J18.80 - Arabidopsis thaliana [truncated orf]
An02g02630	Title: weak similarity to hypothetical ABC-transporter yvfR - Bacillus cereus
An02g02640	Complex: the regulation of vesicular transport in eukaryotic cells involves Ras-like GTPases of the Ypt/Rab family. The S. cerevisiae Yip1 protein specifically binds to the transport GTPases Ypt1p and Ypt31p.; Golgi; Remark: alternate name for S. cerevisiae Yip1: YGR172C.; Similarity: the ORF encoded protein shows strong similarity to human secreted protein encoded by gene 82 clone HSKHL65 from patent WO9842738-A1, but its function is not clearly enough decribed.; Title: similarity to Golgi membrane protein Yip1 -Saccharomyces cerevisiae; See PMID 11278413; See PMID 9724632
An02g02650	Complex: Yrb2p binds to GTP-Gsp1p, but not to GDP-Gsp1p. Yrb2p also binds to the Ran nucleotide exchanger Prp20p/Rcc1 as well as to a novel 150-kDa GTP-binding protein.; Function: Yrb2p is involved in export of nuclear export signal (NES)-containing proteins out of the nucleus.; Localization: Yrb2p is located inside the nucleus,and this localization relies on the N terminus.; Remark: Yrb2p interacts with Xpo1p and not with other members of the importin/karyopherin beta superfamily.; Remark: the Ran binding domain of Yrb2p is essential for function and for its association with Prp20p and the GTP-binding proteins.; Similarity: the predicted A. niger protein shows similarity to Yrb2p (YRB2) of S. cerevisiae, a brefeldin A resistance protein from S. pombe, which is the S. pombe orthologue of Yrb2p of S. cerevisiae, and nuclear pore protein NUP2 from S. cerevisiae. the systematic name of yeast Yrb2p is YIL063c.; Title: similarity to protein Yrb2 - Saccharomyces cerevisiae; nucleus; See PMID 9121474; See PMID 9395535; See PMID 9636166; See PMID 10050047
An02g02660	Remark: alternate name for S. cerevisiae Dcw1 is YKL046c.; Title: strong similarity to hypothetical protein Dcw1 - Saccharomyces cerevisiae
An02g02680	Function: the musN gene from E. nidulans was identified in a screen searching for methyl methane-sulfonate (MMS)-sensitive and radiation-induced mutants. Further characterization showed the musN mutation apparently caused high levels solely of mitotic crossing over.; Similarity: the ORF encoded protein is strong similar to many probable RNA helicases e. g. SPAC23A1. 19c (S. pombe) and YDR291w (S. cerevisiae).; Title: similarity to RecQ helicase musN -Aspergillus nidulans; See PMID 1582555
An02g02690	Similarity: the Pro1 protein from Sordaria macrospora is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to transcription factor required for fruiting body development Pro1 - Sordaria macrospora; See PMID 10224253
An02g02700	Catalytic activity: 10-formyltetrahydrofolate + 5'-phosphoribosylglycinamide <=> tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide.; Pathway: the S. cerevisiae Ade8 gene product is involved in third step (the first of two transformylation reactions) in de novo purine biosynthesis.; Remark: alternate names for S. cerevisiae Ade8: YDR408c,GART or GARtransformylase.; Title: strong similarity to phosphoribosylglycinamide formyltransferase Ade8 -Saccharomyces cerevisiae; See PMID 2183217; See PMID 4581491
An02g02710	Remark: A splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein shows also strong similarity to the S. pombe hypothetical protein SPBP4H10. 07, but the similarity to SPCC4G3. 12c is more extented. It also show many hits to hypothetical Arabidopsis thaliana RING-H2 finger proteins.; Title: strong similarity to hypothetical RING finger protein SPCC4G3.12c - Schizosaccharomyces pombe
An02g02720	Function: Colicins are polypeptide toxins produced by and active against, Escherichia coli and closely related bacteria.; Function: the Colicin E9 is a plasmid-coded bactericidal protein with an endonuclease activity for both single-and double-stranded DNA with undefined specificity.; Title: similarity to Colicin E9 - Escherichia coli; See PMID 9716496; See PMID 2646600
An02g02730	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An02g02740	Complex: Rabex-5 from Bos taurus forms a tight physical complex with Rabaptin-5, and this complex is essential for endocytic membrane fusion.; Function: Rabex-5 displays GDP/GTP exchange activity on Rab5(a small GTPase Rab5 which plays an essential role in endocytic traffic) upon delivery of the GTPase to the membrane.; Similarity: the ORF encoded protein and the Rabex-5 protein from Bos taurus show similarity to the VPS9 protein from S. cerevisiae which is required for Golgi to vacuole trafficking.; Title: similarity to Rab5 GDP/GTP exchange factor Rabex-5 - Bos taurus; See PMID 9323142; See PMID 10633070
An02g02750	Catalytic activity: 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Cofactor: Heme; Manganese.; Function: the catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Title: strong similarity to catalase cta1p -Schizosaccharomyces pombe; See PMID 8537298; See PMID 10380645
An02g02760	Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: weak similarity to skeleton binding protein 1 Pfsbp1 - Plasmodium falciparum
An02g02780	Function: TOXA of C. carbonum exports the cyclic tetrapeptide HC-toxin, which is responsible for the maize pathogenicity of the fungus.; Function: TOXA of C. carbonum may function in self-protection against the HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997
An02g02790	Function: Filobasidiella neoformans produces a thick extracellular polysaccharide capsule, which is well recognized as a virulence factor. CAP10 from Filobasidiella neoformans is required for capsule formation.; Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503
An02g02810	Function: Mal11 from S. cerevisiae is a high-affinity transporter for uptake of alpha-glucosides such as maltose, turanose, isomaltose,alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. It acts with the concomitant export of a proton (symport system).; Remark: alternate names for S. cerevisiae Mal11: Agt1 or YGR289C.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; See PMID 8594329
An02g02820	Catalytic activity: (3S)-3-hydroxyacyl-CoA <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed by the rat mitochondrial enoyl-CoA hydratase ECHS1.; Title: strong similarity to mitochondrial enoyl-CoA hydratase ECHS1 - Rattus norvegicus; localisation:mitochondrion; See PMID 8895557; See PMID 2806264
An02g02830	Golgi; Remark: the human RER1 protein complements the phenotype (mislocalization of the Sec12-reporter protein) of a S. cerevisiae rer1 mutant.; Title: strong similarity to protein RER1 - Homo sapiens; See PMID 9309388
An02g02840	Title: similarity to protein involved in betaine lipid production btaA from patent WO200283844-A2 -Agrobacterium tumefaciens
An02g02850	Remark: alternate name for B. subtilis ISP-1: IspA.; Similarity: Only the c-terminal part of the ORF encoded protein shows similarity to the serine proteinase IspA from B. subtilis, the n-terminal part shows weak similarity to the mammalian transcription factors (e. g. NF-kappa-B2).; Title: similarity to intracellular microbial serine proteinase ISP-1 - Bacillus subtilis; See PMID 3087947
An02g02860	Title: similarity to hypothetical protein encoded by An15g05550 - Aspergillus niger
An02g02870	Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Cofactor: Zinc.; Remark: the Emericella nidulans functional cDNA encoding the alcohol dehydrogenase (ADHIII) was isolated by its ability to complement an adh1 mutation in S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the alcohol-dehydrogenase from A. niger AdhA described in patent WO8704464-A.; Title: strong similarity to alcohol dehydrogenase adhIII - Aspergillus nidulans; See PMID 2998782
An02g02880	Function: biochemical analyses of purified recombinant yeast ARL1 (yARL1) protein revealed properties similar to other ADP-ribosylation factors (ARFs) e. g. the ability to bind and hydrolyze GTP.; Remark: The amino terminus of Arl1 from S. cerevisiae is myristoylated.; Remark: alternate name for S. cerevisiae Alr1: YBR164c.; Title: strong similarity to ADP-ribosylation factor-like protein Arl1 - Saccharomyces cerevisiae; See PMID 9388248
An02g02890	Similarity: the ORF encoded protein shows also similarity A. chrysogenum gamma-actin described in patent WO9839459-A1.; Similarity: the ORF encoded protein shows strong similarity to the not functionally characterized proteins from S. cervisiae ARP8 type e. g. the actin-like protein SPAC664. 02c, S. pombe.; Title: similarity to actin cps8p -Schizosaccharomyces pombe; cytoskeleton; See PMID 8292390; See PMID 8774852; See PMID 3309892
An02g02900	Complex: Paf1 was identified by affinity chromatography, it is member of a collection of factors that associate with S. cerevisiae RNA polymerase II.; Remark: alternate name for S. cerevisiae Paf1: YBR279W.; Title: strong similarity to RNA polymerase II-associated factor Paf1 - Saccharomyces cerevisiae; nucleus; See PMID 8552095; See PMID 9891041; See PMID 10219085
An02g02910	Catalytic activity: (S)-dihydroorotate + NAD(+) <=> orotate + NADH.; Cofactor: FAD; FMN.; Pathway: the PyrE gene product from Emericella nidulans is involved in the pyrimidine metabolism.; Remark: alternate name for E. nidulans PyrE: DHO-DH.; Remark: the orotate reductase PyrE from Emericella nidulans is the target site of the antifungal compound LY214352 [8-chloro-4-(2-chloro-4-fluorophenoxy) quinoline].; Title: strong similarity to orotate reductase pyrE -Aspergillus nidulans; See PMID 8660469
An02g02920	Catalytic activity: D-glyceraldehyde 3-phosphate <=> glycerone phosphate.; Pathway: the TpiA product from B. stearothermophilus is involved in Glycolysis,Gluconeogenesis,Glycerolipid metabolism, Fructose and mannose metabolism.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent WO9928475-A2.; Title: strong similarity to triosephosphate isomerase tpiA - Bacillus stearothermophilus; See PMID 6105959; See PMID 8244026; See PMID 8421318
An02g02930	Catalytic activity: D-ribose 5-phosphate <=> D-ribulose 5-phosphate.; Complex: ribose-5-phosphate isomerase RpiB from Escherichia coli is a homodimer.; Pathway: the RpiB product from E. coli is involved in the nonoxidative branch of the pentose phosphate pathway.; Title: strong similarity to ribose-5-phosphate isomerase rpiB - Escherichia coli; See PMID 8576032
An02g02940	Function: the mammalian Chip homologue is well characterized as chaperone Pubmed 10330192.; Remark: the Drosophila melanogaster Chip protein plays a important role in fly development.; Similarity: the ORF encoded protein shows also strong similarity to the human PPRM-1 protein described in patent WO9949037-A2.; Title: strong similarity to Hsp70-interacting protein Chip - Drosophila melanogaster; See PMID 10488341
An02g02950	Catalytic activity: ATP + {tetrahydrofolyl-[Glu]}(N) + L-glutamate <=> ADP + phosphate + {tetrahydrofolyl-[Glu]}(N+1).; Function: in organisms that synthesize folate coenzymes de novo, the addition of the glutamyl side chains is achieved by the action of two enzymes, dihydrofolate synthetase and folylpolyglutamate synthetase.; Remark: alternate name for S. cerevisiae Met7: YOR241w.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10799479
An02g02960	Function: the ACBP type 2 from Saccharomyces carlsbergensis binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.; Remark: alternate name for S. carlsbergensis ACBP type 2: ACB2.; Similarity: the DNA sequence of the ORF is nearly identical to the A. niger EST Nig058c.; Title: similarity to acyl-CoA-binding type 2 protein Acbp - Saccharomyces carlsbergensis; See PMID 8093000; See PMID 9434347
An02g02970	Similarity: the ORF encoded protein shows similarity to a yet unpublished human tyrosyl-DNA phosphodiesterase TDP1 (literature about this, but which does not describe this protein directly: Pubmed 10521354).; Title: strong similarity to hypothetical protein SPCP31B10.05 - Schizosaccharomyces pombe
An02g02980	Function: the Die2 protein promotes the expression of the inositol transporter gene ITR1 in S. cerevisiae.; Remark: alternate names for S. cerevisiae Die2: YGR227W, Alg10.; Title: strong similarity to protein influencing Itr1 expression Die2 - Saccharomyces cerevisiae; See PMID 7565092
An02g02990	Title: similarity to hypothetical protein OSJNBa0049B20.21 - Oryza sativa
An02g03000	Similarity: the ORF encoded protein shows significant similarity to S. pombe SPCC4G3. 13c and to mammalian AMFR, but this proteins are functionally not characterized.; Title: weak similarity to B-type cyclin - Nicotiana tabacum; See PMID 8580965; See PMID 9193070
An02g03010	Function: the S. pombe Cut14 protein is involved in chromosome segregation.; Remark: better characterized are the human and the chicken homologues Pubmed 7929577;9789013;10958694; Similarity: the S. pombe Cut14 protein belongs to the SMC family.; Title: strong similarity to chromosome segregation protein cut14p - Schizosaccharomyces pombe; nucleus; See PMID 8395535
An02g03060	Title: weak similarity to hypothetical protein T12C22.20 - Arabidopsis thaliana
An02g03070	Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178
An02g03100	Title: strong similarity to hypothetical protein encoded by An04g09510 - Aspergillus niger
An02g03090	Complex: human NOT2, NOT3, NOT4 and a CAF1-like factor, CALIF form a protein complex like their yeast homologues.; Remark: the yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription.; Title: similarity to Not2p - Homo sapiens; See PMID 10637334
An02g03110	Remark: YmL4 of S. cerevisiae is also called MRPL4,YLR439W, or L9753. 1.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml4 - Saccharomyces cerevisiae; See PMID 7828914
An02g03120	Function: Regulates vesicle traffic in secretory pathway by regulating dissociation of GDP from Sec4/Ypt/rab family of GTP-binding proteins.; Title: strong similarity to GDP dissociation inhibitor in the secretory pathway Gdi1 - Saccharomyces cerevisiae; See PMID 8157010
An02g03140	Remark: ORC binds chromatin throughout the cell cycle.; Remark: origin recognition complex binds to sequences A and B1 of the DNA replication origins.; Remark: origin recognition complex(ORC) is comprised of Orc1p, Rrr1p, Orc3p, Orc4p, Orc5p, and Orc6p.; Title: similarity to origin recognition complex subunit 4-related protein orp4p - Schizosaccharomyces pombe; See PMID 10077566; See PMID 10713440
An02g03160	Function: flbA encodes an Emericella nidulans RGS (regulator of G protein signaling) domain protein that is required for control of mycelial proliferation and activation of asexual sporulation.; Title: strong similarity to developmental regulator flbA - Aspergillus nidulans; See PMID 7830576; See PMID 8895563; See PMID 11156981
An02g03170	Title: weak similarity to lactose operon repressor lacI - Escherichia coli
An02g03180	Complex: the S. cerevisiae Cdc73 protein was found in complexes with RNA polymerase II and Paf1p. The Cdc73p,Paf1p complex includes Gal11p TFIIb and TFIIF, but lacks TBP, TFIIH TFIIS and Srbps.; Remark: alternate name for S. cerevisiae Cdc73: YLR418c.; Title: strong similarity to DNA-directed RNA polymerase II accessory protein Cdc73 - Saccharomyces cerevisiae; nucleus; See PMID 9032243
An02g03190	Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555
An02g03200	Title: strong similarity to hypothetical protein Pep2 - Nectria haematococca
An02g03210	Complex: the human SRm160 and a related protein SRm300 (the 300-kD nuclear matrix antigen recognized by mAb B4A11) form a complex that is required for the splicing of specific pre-mRNAs.; Similarity: the similarity of the ORF encoded protein to SRm160 is partly based on repetitive structures.; Title: similarity to SR-related matrix protein of 160 kD SRm160 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10339552; See PMID 10694877
An02g03220	Function: the PrnB product is required for high-affinity proline transport in A. nidulans.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8550020; See PMID 2664423; See PMID 7590163
An02g03230	Complex: the Seh1 protein from S. cerevisiae interacts with Nup84, Nup85, Nup120 and Sec13.; Function: the Seh1 protein from S. cerevisiae required for correct nuclear pore biogenesis.; Localization: the Seh1 protein from S. cerevisiae is localized at the nuclear pore complex.; Remark: alternate names for S. cerevisiae Seh1: Sec13p homolog or YGL100w.; Similarity: the ORF encoded Protein and the Seh1 protein from S. cerevisiae are strong similar to the S. cerevisiae Sec13.; Title: strong similarity to nucleoporin-interacting component Seh1 - Saccharomyces cerevisiae; nucleus; See PMID 8565072
An02g03240	Catalytic activity: UDP-N-acetyl-D-glucosamine + dolichyl phosphate <=> UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.; Function: the Alg7 product from S. cerevisiae catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.; Remark: alternate names for S. cerevisiae Alg7: Tur1, GPT or YBR243C.; Title: strong similarity to UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Alg7 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7873591; See PMID 2678101
An02g03250	Catalytic activity: 3-isopropylmalate <=> 2-isopropylmaleate + H(2)O; Remark: Also: 2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3- carboxypentanone, thus bringing about an interconversion between the two isomers.; Title: strong similarity to 3-isopropylmalate dehydratase LEU2 - Phycomyces blakesleeanus
An02g03260	Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe
An02g03270	Catalytic activity: 5-methyltetrahydrofolate + NADP(+) <=> 5,10-methylenetetrahydrofolate + NADPH; Cofactor: FAD; Remark: two contradictory functions have been assigned to yeast MET13: methylenetetrahydrofolate reductase and mitochondrial ribosomal protein.; Title: strong similarity to methylenetetrahydrofolate reductase Met13 - Saccharomyces cerevisiae; localisation:mitochondrion
An02g03280	Title: similarity to hypothetical protein UNC-89 -Caenorhabditis elegans; See PMID 9427008; See PMID 10591098; See PMID 10677831
An02g03290	Title: strong similarity to hypothetical protein SPCC4G3.11 - Schizosaccharomyces pombe
An02g03300	Catalytic activity: ATP + H(2)O <=> ADP + phosphate; Title: strong similarity to vacuolar ATPase subunit F - Neurospora crassa; See PMID 10340846
An02g03310	Title: strong similarity to hypothetical phosphatidylglycerol/phosphatidylinositol transfer protein pltpao - Aspergillus oryzae
An02g03320	Catalytic activity: Acyl-CoA + acetyl-CoA <=> CoA + 3-oxoacyl-CoA.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; See PMID 7916689
An02g03330	Catalytic activity: long-chain fatty acyl-CoA synthetases catalyse ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Title: strong similarity to very long-chain fatty acyl-CoA synthase Fat1 - Saccharomyces cerevisiae; See PMID 9660783
An02g03340	Title: similarity to hypothetical protein Aut4 -Saccharomyces cerevisiae
An02g03350	Title: strong similarity to hypothetical rev interacting protein mis3p - Schizosaccharomyces pombe
An02g03360	Title: similarity to hypothetical protein CAD21381.1 - Neurospora crassa
An02g03380	Title: strong similarity to hypothetical protein EAA61757.1 - Aspergillus nidulans
An02g03390	Title: strong similarity to spindle pole body protein GCP2 - Homo sapiens; See PMID 9566967
An02g03400	Catalytic activity: Cleavage at Xaa-bonds in which Xaa carries a hydrophobic, basic or acidic side chain.; Complex: S. cerevisiae Pup2p is the alpha-5 subunit of the 20S proteasome core.; Remark: A multisubunit protein abundant in the cytoplasm of most eukaryotic cells, apparently containing at least three distinct endopeptidase active sites. Inhibited by mercurial reagents and some inhibitors of serine endopeptidases. Belongs to peptidase family S25.; Title: strong similarity to proteasome 20S subunit Pup2 - Saccharomyces cerevisiae
An02g03410	Title: strong similarity to protein SEQ ID NO:7875 from patent WO200253728-A2 - Candida albicans
An02g03420	Title: weak similarity to fungal ZBC protein sequence #33 from patent WO200224865-A2 - unidentified organism
An02g03450	Title: weak similarity to hypothetical protein AAA72367.1 - Homo sapiens
An02g03460	Title: similarity to hypothetical protein YIL041w -Saccharomyces cerevisiae
An02g03480	Remark: cells lacking Arv1p display altered intracellular sterol distribution and are defective in sterol uptake, consistent with a role for Arv1p in trafficking sterol into the plasma membrane.; Remark: the S. cerevisiae protein is involved in sterol uptake and distribution into the plasma membrane.; Title: similarity to protein involved in sterol distribution Arv1 - Saccharomyces cerevisiae; See PMID 11063737
An02g03490	Remark: all found proteins found are probable oxidoreductases.; Title: strong similarity to hypothetical oxidoreductase mll4186 - Mesorhizobium loti
An02g03510	Remark: pike AANAT-1 is nearly exclusively expressed in the retina.; Remark: serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2. 3. 1. 87) is the first enzyme in the conversion of serotonin to melatonin.; Title: similarity to arylalkylamine N-acetyltransferase AANAT1 - Esox lucius; See PMID 10085157
An02g03520	Remark: CRFG mRNA was localized to the outer medulla and was highly expressed in epithelial cells. The specific renal expression of CRFG mRNA in the outer medulla was reduced dramatically in several rat models of renal disease, including diabetic nephropathy, partial nephrectomy,ischemia, and anti-Thy1. 1-induced nephritis. CRFG was localized selectively in the nucleus of human and rodent cells, as determined by immunocytochemistry and green fluorescence fusion protein.; Title: strong similarity to G protein-binding protein CRFG - Homo sapiens; See PMID 11316846
An02g03540	Function: low-affinity glucose transporter.; Induction: repressed at high glucose concentrations.; Remark: HXT3::lacZ in S. cerevisiae is maximally expressed after entry into stationary phase.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; See PMID 8417358
An02g03550	Remark: the sequence seems to be a promotor sequence.; Title: weak similarity to hypothetical protein encoded by CG9894 - Drosophila melanogaster
An02g03570	Remark: YBR159w S. cerevisiae has probably 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) activity.; Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: strong similarity to membrane protein YBR159w - Saccharomyces cerevisiae; See PMID 11090658
An02g03580	Remark: strong similarity to S. cerevisiae lipid metabolism protein encoded by the open reading frame YERO44c patent WO200058521-A2.; Remark: the S. cerevisiae protein is involved in the synthesis of ergosterol.; Title: strong similarity to lipid metabolism protein YER044c from patent WO200058521-A2 - Saccharomyces cerevisiae; See PMID 10929718
An02g03590	Catalytic activity: UTP + alpha-D-Galactose 1-phosphate = pyrophosphate + UDPgalactose.; Pathway: galactose metabolism.; Remark: GAL7 converts galactose to glucose in S. cerevisiae.; Similarity: belongs to the UDPglucose-hexose-1-phosphate uridylyltransferases.; Title: strong similarity to UDP-glucose-hexose-1-phosphate uridylyltransferase Gal7 -Saccharomyces cerevisiae; See PMID 10993714; See PMID 2851900; See PMID 6715281
An02g03620	Remark: Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Remark: shows also strong similarity to YLL028w (TPO1) S. cerevisiae.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An02g03630	Remark: all found homologues proteins are deduced to polyketid synthesis clusters in different organisms.; Title: similarity to pimaricin biosynthetic gene cluster protein pimK - Streptomyces natalensis; See PMID 11094342
An02g03640	Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.; Pathway: valine, leucine and isoleucine degradation.; Similarity: belongs to the 3-hydroxyisobutyrate dehydrogenase and related proteins family.; Title: strong similarity to hypothetical 3-hydroxyacid dehydrogenase - Helicobacter pylori
An02g03650	Remark: the protein sequence shows similarity to different prolin rich proteins with different length.
An02g03670	Remark: strong similarity to Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An02g03700	Remark: the ORF shows only to the C-terminal end weak similarity.; Title: weak similarity to nicotinic acetylcholine receptor alpha-4 chain ACh4 - Rattus norvegicus; See PMID 3829125
An02g03710	Title: similarity to hypothetical protein CAD79137.1 - Pirellula sp.
An02g03720	Function: involved in nucleotide excision repair of dna damaged with uv light, bulky adducts, or cross-linking agents.; Remark: Rad4. Rad23 interacts with DNA damage during NER (nucleotide excision repair) and may play a role in recognition of the damage.; Similarity: to S. pombe spac12b10. 12c and some, to mammalian xpcc.; Title: similarity to excision repair protein Rad4 -Saccharomyces cerevisiae; nucleus; See PMID 9837874; See PMID 2649477
An02g03728	Function: Mob1p from S. cerevisiae binds Mps1p (protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation) in a two-hybrid assay.; Function: Mob1p is an essential S. cerevisiae protein; Function: Mutations in Mob1p cause a late nuclear division arrest.; Remark: Mob1p from S. cerevisiae is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro.; Title: similarity to protein involved in cell cycle Mob1 - Saccharomyces cerevisiae; See PMID 9436989
An02g03730	Function: might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: cobalamin biosynthesis.; Title: strong similarity to hypothetical dopamine responsive protein - Rattus norvegicus
An02g03740	Function: human erbB2 catalyzes the phosphorylation of a peptidyl tyrosine residue by ATP.; Remark: the ORF encoded protein shows similarity to several tyrosine kinases of different organisms.; Title: weak similarity to protein-tyrosine kinase erbB2 - Homo sapiens; deleted EC_number 2.7.1.112
An02g03760	Function: PIM1 catalyzes the initial steps of protein degradation.; Function: PIM1 degrades alpha-,beta-, and gamma-subunits of the F1ATPase, the beta-subunit of the matrix processing peptidase (Mas1p) and several mitochondrial ribosomal proteins.; Function: PIM1 probably mediates both assembly of protein complexes and degradation of disassembled proteins; Phenotype: pim1 mutant shows deficiencies in splicing of COX1 and CYTB pre-mRNA and subsequent degradation of the transcripts.; Phenotype: pim1 null mutant has a nonfunctional mitochondrial genome.; Remark: LON and YBL022C are alternative names for PIM1 in S. cerevisiae.; Title: strong similarity to precursor of endopeptidase La-like enzyme Pim1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8276800; See PMID 9585511
An02g03770	Function: MDJ1 of S. cerevisiae is required for proper folding of precursor proteins being transported into the mitochondria.; Phenotype: mdj1 null mutants in S. cerevisiae have petite phenotype and are ts.; Remark: YFL016C is the systematic name for MDJ1.; Title: strong similarity to precursor of heat shock protein Mdj1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8168133
An02g03780	Function: human histidine domain-protein tyrosine phosphatase might be a tumour suppressor.; Remark: the ORFencoded protein also shows similarity to the unknown protein BRO1 of S. cerevisiae. A null mutation in BRO1 is synthetically lethal with null mutations in BCK1, MPK1, which encodes a mitogen-activated protein kinase that functions downstream of Bck1p, or PKC1,a gene encoding a protein kinase C homolog that activates Bck1p.; Title: similarity to histidine domain-protein tyrosine phosphatase from patent WO200063392-A1 - Homo sapiens
An02g03790	Remark: blastp matches are due to repetive amino acids.
An02g03830	Function: creA of A. nidulans is involved in carbon catabolite repression. creA of A. nidulans represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter.; Gene-ID: creA; Mapping: creA from A. niger is mapped to chromosome IV; see list from DSM.; Remark: creA of A. niger complements the creA204 mutation of A. nidulans.; nucleus; See PMID 8359691
An02g03840	Title: strong similarity to hypothetical DNA-binding protein creA - Aspergillus oryzae
An02g03850	Function: snRPG of H. sapiens is associated with small nuclear ribonucleoproteins (sn-RNP) U1, U2 U4/U6 and U5, necessary for mRNA splicing.; Remark: in humans, snRNPs represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE).; Similarity: the predicted ORF belongs to the snRNP Sm proteins family.; Title: similarity to small nuclear ribonucleoprotein G snRPG - Homo sapiens; nucleus; See PMID 7744013
An02g03860	Remark: the ORF encoded protein also shows strong similarity to YPL012w of S. cerevisiae. Loss of function mutations of the unknown protein YPL012w are not viable.; Title: strong similarity to hypothetical protein B1D1.160 - Neurospora crassa
An02g03940	Function: General repressor of transcription (with Tup1p); mediates glucose repression; Title: strong similarity to glucose repression mediator protein Ssn6 - Saccharomyces cerevisiae; See PMID 9733762; See PMID 3316983
An02g03950	Function: the L3 protein is a component of the large subunit of cytoplasmic ribosomes.; Remark: L3 of S. cerevisiae is also called RPL3,TCM1, MAK8, YOR063W or YOR29-14.; Remark: putative sequence error in exon1, no start codon, frameshift between exon 1 and 2.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L3 - Saccharomyces cerevisiae; cytoplasm; See PMID 6355773
An02g03960	Title: strong similarity to hypothetical protein CAD70372.1 - Neurospora crassa
An02g03970	Similarity: the predicted ORF shows weak similarity to asparagine-rich proteins in different organisms.
An02g03980	Function: required for synthesis of beta-1,6-glucan; directly involved in cell surface assembly; may be functionally redundant with Skn1p for beta-1,6-glucan synthesis.; Title: strong similarity to beta-glucan synthesis associated protein Kre6 - Saccharomyces cerevisiae; See PMID 1837148; See PMID 7929594
An02g04000	Catalytic activity: ATP + [pyruvate dehydrogenase (lipoamide)] <=> ADP + [pyruvate dehydrogenase (lipoamide)] phosphate; Function: inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylating the E1 alpha subunit, thus probably contributing to the regulation of glucose metabolism.; Title: strong similarity to pyruvate dehydrogenase kinase isoform 2 - Zea mays
An02g04020	Catalytic activity: N6-(1,2-dicarboxyethyl)AMP <=> fumarate + AMP; Function: Adenylosuccinate lyase ADSL is a bifunctional enzyme, which catalyzes the eight step in the de novo biosynthesis of purines and purine nucleotide recycling.; Function: Adenylosuccinate lyase is one of three enzymes that are involved the purine nucleotide cycle,which converts AMP into IMP and reconverts IMP into AMP.; Title: strong similarity to adenylosuccinate lyase ADSL - Homo sapiens; See PMID 10888601; See PMID 1529104
An02g04030	Remark: 70 kDa exocyst component protein.; Title: strong similarity to 70 kDa exocyst component protein Exo70 - Saccharomyces cerevisiae; See PMID 8978675
An02g04040	Catalytic activity: Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine + Carboxylate.; Title: strong similarity to cytosolic phospholipase A2 beta PLA2G4 - Homo sapiens; See PMID 10358058
An02g04050	Remark: P-TEN is a potential tumor suppressor, that is multiply mutated in many advanced human cancers.; Similarity: the predicted ORF is 149 amino acids longer at the C-terminus than P-TEN of H. sapiens.; Similarity: weak similarity to tensin, as the ORF probably contains a tensin domain, which is also present in P-TEN.; Title: similarity to protein-tyrosine phosphatase P-TEN - Homo sapiens
An02g04070	Title: weak similarity to hypothetical protein BAC84898.1 - Oryza sativa
An02g04080	Remark: homozygosity for the mutation led to a recessive embryonic lethal phenotype.; Remark: putative role in U6 snRNP assembly and function; Title: strong similarity to Small nuclear ribonucleoprotein Lsm4 - Mus musculus; See PMID 10629062
An02g04100	Catalytic activity: Acetyl-CoA + histone <=> CoA + acetyl-histone.; Function: may play a role in telomeric silencing.; Title: strong similarity to histone acetyltransferase Hat1 - Saccharomyces cerevisiae; See PMID 10637607
An02g04110	Catalytic activity: (S)-3-hydroxyacyl-CoA + NAD(+) <=> 3-oxoacyl-CoA + NADH.; Title: similarity to phenylacetaldehyde dehydrogenase padA - Escherichia coli; See PMID 9109378
An02g04120	Title: similarity to protein SEQ ID NO:13148 from patent EP1074617-A2 - Homo sapiens
An02g04130	Remark: sel-10 is a negative regulator of lin-12/Notch-mediated signaling.; Title: similarity to sel-10 - Caenorhabditis elegans; See PMID 9389650; See PMID 9861048
An02g04140	Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein EAA58004.1 - Aspergillus nidulans [truncated ORF]
An02g04150	Title: similarity to hypothetical protein encoded by An16g01110 - Aspergillus niger [truncated ORF]
An02g04160	Remark: O3 exposure for 2 h was sufficient for Mpt1 induction in Betula pendula.; Title: strong similarity to mitochondrial phosphate translocator Mpt1 - Betula pendula; localisation:mitochondrion; See PMID 9349251
An02g04170	Function: phosphophoryn binds tightly to collagen and is believed to initiate the formation of apatite crystals which play a central role in the mineralization process.; Remark: similarity is mainly due to repetitive sequence !; Title: weak similarity to dentin phosphoprotein precursor AAC52774.1 - Rattus norvegicus; See PMID 8702961
An02g04180	Title: strong similarity to hypothetical membrane protein YDL001w - Saccharomyces cerevisiae
An02g04190	Remark: similarities are mainly based on glutamate rich regions.; Title: similarity to hypothetical protein AAP68958.1 - Caenorhabditis elegans
An02g04200	Title: strong similarity to hypothetical protein SPCC4B3.08 - Schizosaccharomyces pombe
An02g04210	Function: OmCLC-3 and OmCLC-5 function as intracellular chloride channels.; Similarity: CLC channels are closely related to the mammalian CLC-3, -4, and-5 subfamily.; Title: strong similarity to chloride channel CLC-3 -Tilapia mossambica; See PMID 10082675
An02g04220	Remark: putative coiled-coil protein; possible motor protein; similar to dynein.; Title: strong similarity to hypothetical coiled-coil protein SPCC737.08 - Schizosaccharomyces pombe
An02g04230	Remark: partial similarity due to repetitive sequence.
An02g04240	Remark: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.; Remark: most blastp hits are due to repetetive sequence motives.; Title: weak similarity to acinusS mRNA - Homo sapiens; See PMID 10490026
An02g04250	Golgi; Remark: p58 in Rattus norvegicus is localized to tubulo-vesicular elements at the endoplasmic reticulum-Golgi interface and the cis-Golgi cisternae in pancreatic acinar cells.; Title: similarity to protein p58 - Rattus norvegicus; See PMID 8626736; See PMID 1478936
An02g04260	Remark: alternate name in Schizosaccharomyces pombe = SPAC17C9. 09c; Title: strong similarity to hypothetical small hypothetical zinc-finger protein tim13p -Schizosaccharomyces pombe
An02g04270	Gene-ID: pkaC; Remark: A number of transformants also showed a strongly reduced or complete absence of sporulation as phenotype, which was quickly lost upon propagation of the strains.; Remark: Transformants overexpressing pkaC were phenotypically different with respect to growth, showing a more compact colony morphology, accompanied by a more dense sporulation, especially on media containing trehalose and glycerol.; deleted EC_number 2.7.1.37; See PMID 9141684
An02g04280	Function: Sin1 of Schizosaccharomyces pombe is a conserved component of the eukaryotic of the stress-activated MAP kinase (SAPK) signal pathway.; Remark: Sin1 of Schizosaccharomyces pombe interacts with Sty1/Spc1 MAP-kinase.; Title: strong similarity to stress activated map kinase interacting protein sin1p - Schizosaccharomyces pombe; See PMID 10428959
An02g04290	Function: RFC1 in S. cerevisiae is probably not involved in repair of double-stranded DNA breaks.; Function: RFC1 in S. cerevisiae may signal end of replication.; Function: RFC1 in S. cerevisiae plays a role in DNA replication and DNA repair; Title: strong similarity to replication factor C chain Rfc1 - Saccharomyces cerevisiae; nucleus; See PMID 7651383
An02g04300	Remark: MRPL16 is component of the large subunit of mitochondrial ribosome in S. cerevisiae.; Remark: alternate name in S. cerevisiae = YBL038w.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L16 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626; See PMID 7478995
An02g04310	Remark: The ubc1 gene encodes a type II regulatory subunit of cAMP-dependent protein kinase (PKA) in Ustilago maydis.; Title: weak similarity to cAMP-dependent protein kinase type II regulatory chain uac1 - Ustilago maydis; See PMID 7995519
An02g04320	Remark: RFC3 is a heteropentamer of subunits of 140/145, 40, 38, 37, and 36. 5 kDa that forms a complex with pcna in the presence of ATP.; Title: strong similarity to replication factor C 38-kDa subunit RFC3 - Homo sapiens; nucleus; See PMID 9488738
An02g04330	Function: COX11 is a nuclear genes of S. cerevisiae whose product is localized in mitochondria and is required for the synthesis/assembly of cytochrome oxidase.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox11 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8118433; See PMID 2167832
An02g04340	Title: similarity to hypothetical protein BAA97377.1 - Arabidopsis thaliana
An02g04350	Remark: CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the c-myc/max complex in Mus musculus in vivo.; Remark: Max forms a sequence-specific DNA-binding protein complex with myc or mad in Mus musculus.; Remark: in Mus musculus the myc-max complex is a transcriptional activator, whereas the mad-max complex is a repressor.; Similarity: Max belongs to members of the myc family of helix-loop-helix transcription factors.; Title: weak similarity to helix-loop-helix transcription factor Max - Mus musculus; nucleus; See PMID 8193530; See PMID 9308235; See PMID 1840505
An02g04360	Title: similarity to hypothetical protein SPCC1235.07 - Schizosaccharomyces pombe
An02g04355	Title: weak similarity to hypothetical protein CAD37032.1 - Neurospora crassa
An02g04370	Similarity: weak similarity to transcription factors of the fungal Zn(2)-Cys(6) binuclear cluster type.; Title: similarity to hypothetical protein B23I11.340 - Neurospora crassa
An02g04380	Title: similarity to hypothetical protein EAA68518.1 - Gibberella zeae
An02g04390	Title: similarity to hypothetical protein CAD37031.1 - Neurospora crassa
An02g04400	Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An02g04410	Remark: Candida albicans FLU1 seems not to be required for the development of azole resistance in clinical isolates of Candida albicans.; Remark: Candida albicans FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters.; Remark: The disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid,thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An02g04420	Title: strong similarity to hypothetical protein encoded by An12g06190 - Aspergillus niger
An02g04430	Catalytic activity: S-Adenosyl-L-methionine = 1-Aminocyclopropane-1-carboxylate + Methylthioadenosine.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate synthase acs -Penicillium citrinum; See PMID 10227140; See PMID 10737185
An02g04440	Function: the S. cerevisiae homolog GAP1 encodes the low affinitiy, high capacity general aminoacid permease which is responsible for uptake of aminoacids as source of nitrogen when grown on media with limited N supply.; Induction: S. cerevisiae GAP1 expression is induced by growth on poor nitrogen sources.; Localization: Gap1p is sorted differently on different nitrogen sorces. Gap1p is found predominantly internally by growth on rich nitrogen sources. when grown on poor nitrogen sources Gap1p is sorted from the golgi to the plasma membran.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane
An02g04460	Title: strong similarity to protein SEQ ID NO:7789 from patent WO200253728-A2 - Candida albicans
An02g04480	Title: strong similarity to hypothetical protein B5O22.190 - Neurospora crassa
An02g04500	Function: S. cerevisiae Rgp1p seems to participate in recycling of proteins from the late endosome to the Golgi.; Remark: the S. cerevisiae homolog RGP1 is significantly shorter.; Title: similarity to golgi recycling factor Rgp1 -Saccharomyces cerevisiae
An02g04510	Complex: S. cerevisiae Mob1 binds the cell cycle-regulated protein kinase Dbf2p.; Function: Mob1p is part of a group of proteins, the mitotic exit network (MEN) required for the telophase/G1 transition, which includes Lte1, Tem1, Cdc5, Cdc15,Dbf2/Dbf20, and Mob1.; Induction: Expression of S. cerevisiae MOB1 is cell cycle-regulated, peaking at the at the G2/M boundary.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to protein required for completion of mitosis and maintenance of ploidy Mob1 -Saccharomyces cerevisiae
An02g04520	Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Similarity: strong similarity to family of H+-transporting ATP synthases.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3989 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to H+-transporting ATP synthase delta chain precursor Atp5 - Saccharomyces cerevisiae; See PMID 7866306
An02g04530	Catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.; Function: the E. coli homolog cfa encodes a cyclopropane fatty acid synthase that catalyzes a modification of the acyl chains of phospholipid bilayers. cfa adds a methylene group across the 9,10 position of a delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative.; Title: strong similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli
An02g04540	Title: strong similarity to hypothetical protein YMR196w - Saccharomyces cerevisiae
An02g04580	Similarity: the ORF shows strong similarity to expressed sequence tag an_2257 from Aspergillus niger.; Title: strong similarity to hypothetical protein YAL049c - Saccharomyces cerevisiae
An02g04590	Title: similarity to hypothetical monocarboxylate permease Esbp6 - Saccharomyces cerevisiae
An02g04620	Remark: similarities are mainly based on repetetive structures.; Remark: there is also some similarity to EST SEQ ID NO:6064 from patent WO200056762-A2 of Aspergillus oryzae.; Title: similarity to S-layer protein - Clostridium thermocellum; See PMID 8458832
An02g04630	Remark: diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in EF2.; Remark: strong similarity to Amino acid sequecne of the DPH1 gene product patent WO9953762-A1.; Title: strong similarity to diphtheria toxin resistance protein DPH1 from patent WO9953762-A1 -Saccharomyces cerevisiae
An02g04640	Catalytic activity: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.; Pathway: synthesis and degradation of ketone bodies; valine, leucine and isoleucine degradation; butanoate metabolism.; Remark: rat liver, cannot produce ketone bodies from fatty acid oxidation but, since the tissue possesses a high activity of HMG-CoA lyase, it produce ketone bodies from leucine catabolism.; Similarity: belongs to the HMG-CoA lyase family.; Title: strong similarity to 3-hydroxy-3-methylglutaryl CoA lyase HMG-CoA lyase - Rattus norvegicus; See PMID 9798904; See PMID 10796071; See PMID 3741427; See PMID 9425122
An02g04650	Title: strong similarity to hypothetical protein EAA59178.1 - Aspergillus nidulans
An02g04660	Title: similarity to hypothetical protein YBR269c -Saccharomyces cerevisiae
An02g04670	Remark: BTN1 is a nonessential gene under most growth conditions which functions in the vacuole in yeast S. cerevisiae.; Remark: Batten disease is caused by a defect in vacuolar (lysosomal) pH control.; Similarity: to human Batten disease-related protein CLN3.; Title: strong similarity to Batten disease-related protein Btn1 - Saccharomyces cerevisiae; See PMID 10319861; See PMID 11053386; See PMID 11332774; See PMID 9753630
An02g04680	Function: lipe of R. norvegicus is a key enzyme in fatty acid mobilization from adipose tissue triglycerides,overall energy homeostasis and probably is important in steroidogenesis.; Function: lipe of R. norvegicus is responsible for hormone-sensitive acylglycerol hydrolase and cholesteryl ester hydrolase activity in a variety of tissues.; Induction: the activity of the hormone-sensitive lipase lipe of R. norvegicus is controlled by insulin.; Title: strong similarity to hormone-sensitive lipase lipe - Rattus norvegicus
An02g04690	Function: carboxypeptidase cdpS from A. saitoi removes acidic, neutral and basic amino acids as well as proline from the C-terminal position of proteins at pH 2-5.; Function: the A. niger carboxypeptidase in addition partially digests preferentially peptides containing a hydrophobic residue in position P1, as well as arginine,lysine or phenylalanine in P1 of ester substrates.; Remark: a putative frameshift due to a possible sequencing error at position 8766 (1 bp too much) was corrected.; Repression: cdpS of A. saitoi is inhibited by DFP (diisopropyl fluorophosphate).; Similarity: the predicted ORF is strongly similar/identical to the precursor form of the published A. niger cdp-I carboxypeptidase, which mature form was described as protein of 471 amino acid, but with 9 different amino acids.; Title: strong similarity to serine-type carboxypeptidase I cdpS - Aspergillus saitoi; putative frameshift; See PMID 1637154; See PMID 7772020; See PMID 9748653
An02g04700	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g04710	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g04720	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g04730	Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae
An02g04740	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g04750	Title: weak similarity to hypothetical protein encoded by CG7709 - Drosophila melanogaster
An02g04760	Title: weak similarity to hypothetical DNA-binding protein DF1 - Pisum sativum
An02g04780	Title: weak similarity to 3,5-cyclic-nucleotide phosphodiesterase regA - Dictyostelium discoideum
An02g04790	Title: similarity to hypothetical protein encoded by An01g02260 - Aspergillus niger
An02g04800	Function: sconB of E. nidulans functions as a negative regulator of sulfur metabolism.; Similarity: belongs to the met30/sconb/scon-2 family of wd-repeat proteins; Similarity: contains 8 wd repeats (trp-asp domains); Title: strong similarity to sulfur metabolite repression control protein sconB - Aspergillus nidulans; See PMID 11085267; See PMID 8479426; See PMID 9520259
An02g04820	Function: APG17 of S. cerevisiae is a component of a Apg1/Cvt9-containing complex, which is involved in autophagy, a membrane trafficking to vacuole/lysosome induced by nutrient starvation necessary for the sequestration and delivery of cytoplasmic material in vacuoles. .; Function: the apg1 complex could be necessary for switching between two distinct vesicular transport systems in a nutrient-dependent manner.; Title: similarity to cytokeratin-like protein Apg17 - Saccharomyces cerevisiae; See PMID 10582243; See PMID 10966461; See PMID 10995454
An02g04830	Remark: sudD of A. nidulans is another suppressor of the bimD6 mutation, which is a recessive,temperature-sensitive lethal mutation. at a restrictive temperature, the chromosomes of bimD6 mutant strains fail to attach properly to the spindle microtubules, and the mutant also displays a high rate of chromosome loss.; Similarity: the predicted A. niger protein shows strong similarity to the extragenic suppressor of the bimD6 mutation (sudD) of A. nidulans and orthologues of diverse eucaryotic species.; Title: strong similarity to extragenic suppressor of the bimD6 mutation sudD - Aspergillus nidulans
An02g04840	Remark: DA-box proteins have been shown to function in chromosome structure and segregation.; Remark: a putative frameshift results in an premature STOP codon.; Remark: sudA of A. nidulans is a suppressor of the bimD6 mutation, which is a recessive, temperature-sensitive lethal mutation.; Similarity: the predicted A. niger protein shows strong similarity to the chromosome scaffold protein (sudA) of A. nidulans and orthologues of diverse eucaryotic species, which belong to the DA-box protein family.; Title: strong similarity to chromosome scaffold protein sudA - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 8849887
An02g04850	Remark: the matching protein is essential for viability in C. albicans.; Title: similarity to protein SEQ ID NO:7804 from patent WO200253728-A2 - Candida albicans
An02g04860	Title: strong similarity to cytochrome-b5 reductase - Saccharomyces cerevisiae; See PMID 8307010
An02g04870	Title: weak similarity to hypothetical phosphatidylinositol-4-phosphate 5-kinase -Schizosaccharomyces pombe; See PMID 9660759
An02g04880	Catalytic activity: ATP + L-arginine + tRNA(arg) = AMP + pyrophosphate + L-arginyl-tRNA(arg); Similarity: shows stronger similarity to cytoplasmic proteins from different species than to mitochondrial localized.; Title: strong similarity to arginine--tRNA ligase Msr1 - Saccharomyces cerevisiae; See PMID 7607232
An02g04900	Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans; Gene-ID: pgaB; Mapping: pgaB from A. niger is mapped to chromosome IV; see EMBL Y18805.; Remark: pgaB-specific mRNA accumulates in mycelia grown on sucrose.; See PMID 10642523
An02g04910	Similarity: the ORF shows similarity to various ABC transporters.; Title: strong similarity to multidrug resistance ABC transporter bfr1p - Schizosaccharomyces pombe; See PMID 9537449
An02g04920	Title: similarity to hypothetical protein encoded by An09g02960 - Aspergillus niger [truncated ORF]
An02g04940	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g04960	Title: strong similarity to hypothetical protein 68B2.80 - Neurospora crassa
An02g04980	Function: ddx21 of H. sapiens can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase).; Remark: ddx21 of H. sapiens is also called nuleolar RNA helicase GU, dead box protein 21 or RHII/GU.; Similarity: the ORF shows similarity to several RNA helicases from different species.; Title: strong similarity to DEAD-box RNA helicase II ddx21 - Homo sapiens; nucleus
An02g04990	Title: strong similarity to hypothetical protein B21J21.225 - Neurospora crassa
An02g05000	Function: acyltransferases catalyse the transfer of acyl groups from a donor to a variety of substrates such as glycerides, sterols, stanols and phosphatides and play a key role in lipid synthesis.; Remark: the patent WO200018889-A2 is corresponding to AAY9948 of the PATENTPROT database; the DNA is found under PATENTDNA AAA37527.; Title: strong similarity to acyltransferase yscat1 from patent WO200018889-A2 - Saccharomyces sp.
An02g05010	Remark: mRpL31 of S. cerevisiae is also called YKL138c, ribosomal protein MRP31 or YmL31.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L31 - Saccharomyces cerevisiae; localisation:mitochondrion
An02g05020	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g05030	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g05070	Remark: LPS1 activates the three amino acids of the peptide portion of ergot peptide alkaloids during D-lysergyl peptide assembly.; Title: strong similarity to d-lysergyl-peptide-synthase PS1 - Claviceps purpurea; cytoplasm; See PMID 10071219; See PMID 1281482
An02g05080	Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199
An02g05090	Function: gibberelin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved, one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641
An02g05100	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An02g05140	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An02g05150	Catalytic activity: C-8,7 sterol isomerase of A. thaliana catalyses the isomerization of the C-8 double bond to the C-7 position within the steroid B ring.; Pathway: C-8,7 sterol isomerase of A. thaliana is involved in steroid biosynthesis.; Remark: the activity of C-8,7 sterol isomerase of A. thaliana is inhibited by the presence of sigma ligands,haloperidol, ifenprodil and verapamil.; Similarity: the predicted A. niger protein shows strong similarity to C-8,7 sterol isomerase of A. thaliana and other members of the superfamily of emopamil-binding proteins.; Title: strong similarity to C-8,7 sterol isomerase -Arabidopsis thaliana
An02g05160	Title: similarity to hypothetical protein encoded by An11g09150 - Aspergillus niger
An02g05170	Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Remark: another ORF An02g05080 also shows strong similarity to Mak1 from N. haematococca.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199
An02g05180	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An02g05190	Remark: the predicted A. niger protein shows strong similarity to the protein sequence of patent EP1033405-A2 (AC# AAG34578) of A. thaliana and several putative zinc finger proteins from divergent organisms.; Title: strong similarity to protein sequence a from patent EP1033405-A2 - Arabidopsis thaliana
An02g05210	Function: synexin (annexin VII) of M. musculus is a calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.; Remark: murine synexin (annexin VII) has four annexin repeats.; Similarity: the predicted A. niger protein shows similarity to murine synexin (annexin VII) and many other proteins that belong to the annexin family.; Title: strong similarity to synexin (annexin VII) -Mus musculus; See PMID 7916616; See PMID 11108960
An02g05220	Function: the human Staf-50 down-regulates the transcription directed by the long terminal repeat promoter region of human immunodeficiency virus type 1 in transfected cells.; Function: the human Staf-50 is a member of the Ring finger family and contains all the features of a transcriptional regulator able to initiate a second cascade of gene induction.; Title: similarity to transcription regulator Staf-50 - Homo sapiens; See PMID 7797467
An02g05230	Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to protein fragment SEQ ID NO: 65270 of patent EP1033405-A2 (AC# AAG51428) and peroxisomal membrane proteins of various species.; Title: similarity to protein fragment SEQ ID NO:65270 from patent EP1033405-A2 - Arabidopsis thaliana
An02g05240	Function: histone H4 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Title: strong similarity to histone 4 from patent WO9919502-A1 - Homo sapiens; nucleus
An02g05260	Function: PTG of M. musculus belongs to a gene family known collectively as glycogen targeting subunits of protein phosphatase-1, that participate in the assembly and regulation of the enzymes of glycogen metabolism within mammalian cells. in addition to binding and localizing phosphatase PP1C to glycogen, PTG formes complexes with phosphorylase kinase, phosphorylase a, and glycogen synthase, the primary enzymes involved in the hormonal regulation of glycogen metabolism.; Similarity: the predicted A. niger protein shows similarity to protein phosphatase 1 binding protein (PTG,also known as PPP1R5) of M. musculus and other species.; Title: similarity to protein phosphatase 1 binding protein PTG - Mus musculus; cytoplasm; See PMID 9045612; See PMID 9756875
An02g05320	Similarity: the predicted A. niger protein shows similarity to the putative verprolin related protein of N. crassa. similarities to other protein sequences are due to low complexity sequences consisting of prolines and serines.; Title: similarity to hypothetical verprolin related protein - Neurospora crassa
An02g05340	Title: strong similarity to hypothetical protein 68B2.110 - Neurospora crassa
An02g05360	Similarity: the predicted A. niger protein shows strong similarity to putative protein 9G6. 360of N. crassa. similarity to other proteins is due to low complexity sequences consisting of threonines.; Title: strong similarity to hypothetical protein 9G6.360 - Neurospora crassa
An02g05380	Function: VPS33 of S. cerevisiae is involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole and that is required for the morphogenesis of vacuoles and subsequent expression of vacuolar functions. VPS33 mutants missort and secrete multiple vacuolar hydrolases and exhibit extreme defects in vacuolar morphology.; Remark: VPS33 of S. cerevisiae is also known as CLS14, MET27, PEP14, SLP1, VAM5, VPL25, VPT33 and has a systematic name of YLR396C.; Similarity: the predicted A. niger protein shows strong similarity to vacuolar protein-sorting protein VPS33 of S. cerevisiae and putative homologues from other species, including a partial C-terminal protein sequence from Aspergillus fumigatus. a partial C-terminal protein sequence (HbrA) from Aspergillus nidulans is covered by patent WO200056893-A1 (AC# AAB29042).; Title: strong similarity to vacuolar protein sorting-associated protein Vps33 - Saccharomyces cerevisiae; cytoplasm; See PMID 2183024; See PMID 2201898; See PMID 3062374; See PMID 3131304; See PMID 3131305
An02g05390	Complex: SEC9 of S. cerevisiae is physically associated with two proteins that are homologous to components of the neuronal SNARE complex.; Function: SEC9 of S. cerevisiae is a t-SNARE required for post-Golgi vesicle fusion of secretory vesicles with the plasma membrane.; Localization: SEC9 of S. cerevisiae is bound to the yeast plasma membrane, but absent from post-Golgi vesicles.; Similarity: the predicted A. niger protein shows strong similarity to SEC9 of S. cerevisiae and several synaptosomal proteins like SNAP-25.; Title: strong similarity to t-SNARE Sec9 -Saccharomyces cerevisiae; plasma membrane
An02g05400	Remark: the 146D nuclear protein of X. laevis is found in the nucleoplasm with high local concentrations during interphase. during mitosis, when transcription and splicing are downregulated, the protein is released from the nuclear speckles and transiently dispersed throughout the cytoplasm.; Remark: the 146D nuclear protein of X. laevis is part of a large particle of approximately 12S.; Similarity: the predicted A. niger protein shows strong similarity to the 146D nuclear protein of X. laevis,human spliceosomal protein SAP 155 and other putative nuclear proteins.; Title: strong similarity to 146D nuclear protein -Xenopus laevis; nucleus; See PMID 9436997
An02g05410	Catalytic activity: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina catalyses the reaction succinate + acceptor <=> fumarate + reduced acceptor.; Cofactor: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina is a flavoprotein (FAD) and contains iron-sulfur centres.; Complex: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina is a component of succinate dehydrogenase (EC 1. 3. 5. 1).; Pathway: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarin is involved in the citrate cycle, oxidative phosphorylation, butanoate metabolism and the reductive carboxylate cycle (CO2 fixation).; Remark: Shewanella frigidimarina was formerly named S. putrefaciens.; Similarity: the predicted protein of A. niger shows strong similarity to fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina and from many other species.; Title: strong similarity to fumarate reductase flavocytochrome c3 fccA - Shewanella frigidimarina; See PMID 10479620
An02g05420	Similarity: the predicted A. niger protein shows strong similarity to the putative zinc finger protein (flbC) of A. nidulans and similarity to the C2H2 domain of many zinc finger proteins of the Kruppel subfamily.; Title: strong similarity to hypothetical zinc-finger protein flbC - Aspergillus nidulans
An02g05430	Title: questionable ORF
An02g05440	Similarity: the predicted A. niger protein shows also similarity to the C-termini of hypothetical proteins from M. musculus and H. sapiens.; Title: similarity to hypothetical protein Leucine-rich protein - Schizosaccharomyces pombe
An02g05450	Complex: human hUba3 forms a complex with APP-BP1 (amyloid precursor protein-binding protein) which behaves like the ubiquitin activating enzyme E1 in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. hUba3 contains the active cysteine and ATP binding site.; Function: expression of human APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and this function requires both hUba3 and hUbc12 (a human homolog of yeast Ub-conjugating enzyme Ubc12p).; Remark: the protein sequence of human hUba3, here named NAE1-beta protein, is covered by patent WO9932624-A1 (AC# AAY25339).; Remark: ubiquitin (ub) and ubiquitin-like proteins (i. e. human NEDD8) are ligated to proteins by a protein system consisting of E1- (Ub-activating), E2-like (Ub-conjugating) enzymes and E3 (Ub-ligating) enzymes. the covalent attachment of ubiquitin to other proteins mediates the selective degradation of short-lived and abnormal proteins.; Title: strong similarity to Nedd8-activating enzyme hUba3 - Homo sapiens; See PMID 9694792; See PMID 10722740
An02g05460	Complex: RCP40 of S. cerevisiae associates with RCP19 of S. cerevisiae, another subunit shared only by RNAP I and RNAP III. The RCP19/RCP40 heterodimer interacts with the ABC10 beta subunit (encoded by RPB10) of S. cerevisiae, which is one of the five polypeptides common to all three nuclear RNA polymerases.; Complex: RCP40 of S. cerevisiae is a subunit of RNA polymerases I(A) (RNAP I) and III(C) (RNAP III), but not RNA polymerase II.; Remark: RCP40 of S. cerevisiae is also called AC40,RPC5, YPR110C or P8283. 18.; Remark: RCP40 of S. cerevisiae is unique in the yeast genome and is required for cell viability.; Similarity: the predicted A. niger protein shows strong similarity to RPC40, a subunit of RNA polymerase I and III from S. cerevisiae and many other eucaryotic organisms. RCP40 of S. cerevisiae shows a local sequence similarity to prokaryotic alpha subunits.; Title: strong similarity to 40 kD subunit of DNA-directed RNA polymerase I,III Rpc40 - Saccharomyces cerevisiae; nucleus; See PMID 8516295; See PMID 3815519
An02g05470	Catalytic activity: NADH:ubiquinone oxidoreductase catalyses the reaction NADH + ubiquinone = NADH(+) + ubiquinol.; Cofactor: NADH:ubiquinone oxidoreductase requires iron-sulfur as a cofactor.; Complex: the 49 kd subunit from N. crassa is a component of the iron-sulphur subcomplex of the enzyme.; Function: the proton-pumping NADH:ubiquinone oxidoreductase is the first of the respiratory chain complexes in many bacteria and mitochondria of most eukaryotes. NADH:ubiquinone oxidoreductase transfers electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.; Localization: NADH:ubiquinone oxidoreductase is located on the matrix side of the mitochondrial inner membrane.; Remark: the mitochondrial NADH-ubiquinone reductase (complex I) is an assembly of approximately 30 different polypeptides. the 49 kd subunit from N. crassa is a nuclear gene product, that is imported into the mitochondria.; Similarity: the predicted A. niger protein shows strong similarity to the mitochondrial 49 K subunit of NADH: ubiquinone reductase (complex I) from N. crassa and many other eucaryotic and procaryotic organisms.; Title: strong similarity to 49 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 11004444; See PMID 2147127
An02g05480	Function: the protein encoded by UBC2-1 from A. thaliana is shown to accept 125I-ubiquitin from wheat E1 enzymes, when expressed from E. coli hosts as fusion protein carrying N-terminal extensions. UBC2-1 is deubiquitinated in the presence of lysine and, by these criteria, is considered a functional E2 enzyme.; Remark: ubiquitin (ub) and ubiquitin-like proteins are ligated to proteins by a protein system consisting of E1- (Ub-activating), E2-like (Ub-conjugating) enzymes and E3 (Ub-ligating) enzymes. the covalent attachment of ubiquitin to other proteins mediates the selective degradation of short-lived and abnormal proteins.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. an intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Title: strong similarity to ubiquitin conjugating enzyme UBC2 - Arabidopsis thaliana; See PMID 8219072
An02g05490	Catalytic activity: CMK2 of S. cerevisiae catalyses the reaction ATP + protein = ADP + O-phosphoprotein.; Cofactor: CMK2 of S. cerevisiae needs Ca2+/calmodulin as a cofactor.; Remark: CMK1 and CMK2 of S. cerevisiae were found to have different biochemical properties in terms of autoregulatory activity and preference for yeast CaM or bovine CaM for maximal activity.; Remark: mutant S. cerevisiae cells with deletion of CMK2, or both CMK1 and CMK2, are viable, although loss of CMK2 causes a slow rate of spore germination.; Similarity: the predicted A. niger protein shows strong similarity to Ca2+/calmodulin-dependent protein kinase (CMK2) from S. cerevisiae and many other eucaryotic organisms. in S. cerevisiae, there are two known Ca2+/calmodulin-dependent protein kinases, CMK1 and CMK2.; Title: strong similarity to Ca(2+)/calmodulin-dependent protein kinase Cmk2 -Saccharomyces cerevisiae; See PMID 2026147; See PMID 2061341
An02g05530	Function: severin kinase is a kinase from cytosolic extracts that specifically phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein.; Pathway: the presence of severin kinase in Dictyostelium suggests a direct signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Similarity: the central part of the predicted A. niger protein shows strong similarity to severin kinase from D. discoideum and (mostly hypothetical) kinases from diverse eucaryotic species, that belong to the Ste20p- or p21-activated protein kinase family.; Title: similarity to severin kinase - Dictyostelium discoideum; cytoplasm; See PMID 9582328
An02g05540	Catalytic activity: kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus catalyses the reaction L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate and the reaction L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.; Cofactor: kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus needs pyridoxal-phosphate as a co-factor.; Function: kynurenine aminotransferase catalyses the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid, which is thought to be an endogenous modulator of glutamatergic neurotransmission.; Similarity: the predicted A. niger protein shows strong similarity to kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus, but also to probable valine-pyruvate transaminase of S. pombe.; Title: strong similarity to kynurenine/alpha-aminoadipate aminotransferase - Rattus norvegicus; cytoplasm; See PMID 7493966
An02g05560	Catalytic activity: 2,3-dihydroxybenzoic acid decarboxylase of A. niger catalyses the reaction 2,3-dihydroxybenzoate = catechol + CO(2).; Complex: 2,3-dihydroxybenzoic acid decarboxylase is a homotetramer.; Pathway: 2,3-dihydroxybenzoic acid decarboxylase of A. niger catalyses the last step in the metabolism of indole to catechol.; Remark: the products of the invention can be used in a method to produce aromatic hydrocarbons, particularly catechol which is used in the development of pharmaceuticals such as L-DOPA and adrenaline,agrobiochemicals such as carbofuran, and antioxidants such as 4-tert-butyl catechol and veratol. unlike the invention,prior art aromatic hydrocarbon production methods involve the use of non-renewable resources, have a negative impact on the environment, and involve high temperatures and acid conditions which pose environmental and safety concerns,are expensive and are energy consuming.; Similarity: the predicted A. niger protein shows strong similarity, but not identity, to the protein sequence 2,3-dihydroxybenzoic acid decarboxylase of patent WO9909048-A1 of A. niger (AC# AAW93483).; Title: strong similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger; cytoplasm
An02g05570	Title: weak similarity to hypothetical protein encoded by An17g00640 - Aspergillus niger
An02g05590	Catalytic activity: benzoylformate decarboxylase of P. putida catalyses the reaction benzoylformate = benzaldehyde + CO(2); Cofactor: benzoylformate decarboxylase of P. putida requires thiamine pyrophosphate as a cofactor.; Pathway: benzoylformate decarboxylase of P. putida is one of the five known enzymes of the mandelate pathway.; Remark: the genes for (S)-mandelate dehydrogenase,benzoylformate decarboxylase and mandelate racemase of P. putida are organized in an operon (mdlCBA).; Title: similarity to benzoylformate decarboxylase -Pseudomonas putida; cytoplasm; See PMID 2271624
An02g05600	Title: strong similarity to hypothetical protein CAD70734.1 - Neurospora crassa
An02g05610	Catalytic activity: branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus catalyzes the reaction ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate.; Complex: mammalian mitochondrial branched-chain alpha-ketoacid dehydrogenase complex consists of three catalytic components: E1 (a heterotetrameric thiamine pyrophosphate-dependent decarboxylase), E2 (a 24-mer of identical lipoate-bearing proteins), E3 (a dimeric dehydrogenase) and two regulatory enzymes, a specific kinase (branched-chain alpha-ketoacid dehydrogenase kinase) and a specific phosphatase, which control enzyme activity by reversible phosphorylation/dephosphorylation.; Function: branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways.; Remark: alpha-chloroisocaproate and dichloroacetate inhibit branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus; Similarity: the predicted A. niger protein shows strong similarity to branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) from R. norvegicus, which belongs to the PDK(pyruvate dehydrogenase kinase)/BCKDK family of protein kinases.; Title: strong similarity to branched-chain alpha-ketoacid dehydrogenase kinase BCKDK - Rattus norvegicus; localisation:mitochondrion
An02g05620	Similarity: the predicted A. niger protein shows strong similarity to the five ESTs an_2860, an_2570,an_2857, AN06C0 and an_2883 of A. niger.; Similarity: the predicted A. niger protein shows weak similarity to the hypothetical protein YHR138c from S. cerevisiae, which is similar to yeast protease B inhibitor 2 (PBI2).; Title: weak similarity to hypothetical protein encoded by An07g10060 - Aspergillus niger
An02g05630	Induction: the N. crassa HAK1 transporter is only expressed when cells are K+ starved.; Remark: the N. crassa HAK1 transporter expressed by the corresponding cDNAs in a trk1 delta trk2 delta mutant of S. cerevisiae exhibits a high affinity for Rb+ and K+.; Remark: the N. crassa HAK1 transporter shows a high concentrative capacity and is the K(+)-H+ symporter described in N. crassa.; Title: strong similarity to potassium transporter hak-1 - Neurospora crassa; plasma membrane; See PMID 10027968
An02g05640	Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein SPAC11D3. 03c from S. pombe and also strong similarity to the hypothetical protein CG10208 of D. melanogaster, but only weak similarity to hypothetical proteins from several procaryotic organisms.; Title: strong similarity to hypothetical protein SPAC11D3.03c - Schizosaccharomyces pombe
An02g05650	Remark: the N-terminus of the human protein sequence is covered by patent WO200073801-A2 (AC# AAB63577).; Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein YPL217c from S. cerevisiae and also strong similarity to hypothetical proteins from several eucaryotic organisms.; Title: strong similarity to hypothetical protein YPL217c - Saccharomyces cerevisiae
An02g05670	Catalytic activity: lactoylglutathione lyase (glyoxalase-I) of L. esculentum catalyses the reaction (R)-S-lactoylglutathione = glutathione + methylglyoxal.; Cofactor: glyoxalase-I of L. esculentum contains zinc (by similarity).; Function: glyoxalase-I of L. esculentum catalyses the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (by similarity) and thus may serve to detoxify methylglyoxal produced from triosephosphates in all cells.; Induction: glyoxalase-I of L. esculentum is induced by salt-stress.; Pathway: glyoxalase-I of L. esculentum belongs to the glyoxal pathway.; Similarity: the predicted A. niger protein shows similarity to lactoylglutathione lyase (glyoxalase-I) of L. esculentum, which belongs to the glyoxalase I family.; Title: similarity to lactoylglutathione lyase glyoxalase-I - Lycopersicon esculentum; See PMID 8616220
An02g05680	Title: strong similarity to hypothetical protein EAA62513.1 - Aspergillus nidulans
An02g05690	Title: similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe
An02g05700	Function: eEF-2 of C. griseus promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.; Remark: eEF-2 of C. griseus is completely inactivated by phosphorylation mediated by EF-2 kinase.; Similarity: the predicted A. niger protein shows strong similarity to GTP-binding translation elongation factor eEF-2 of C. griseus, which belongs to the EF-G/EF-2 family.; Title: strong similarity to translation elongation factor eEF-2 - Cricetulus griseus; cytoplasm
An02g05730	Catalytic activity: cellulose synthase of A. xylinum catalyses the reaction UDP-glucose + {(1,4)-beta-D-glucosyl}(N) = UDP + {(1,4)-beta-D-glucosyl}(N+1).; Pathway: cellulose synthase of A. xylinum is involved in the synthesis of cellulose.; Remark: cellulose synthase of A. xylinum is the second protein encoded by the cellulose biosynthesis (bcs) operon.; Title: similarity to cellulose synthase protein bcsB - Acetobacter xylinum; See PMID 2146681; See PMID 2151718
An02g05740	Title: strong similarity to hypothetical membrane protein YLR087c - Saccharomyces cerevisiae
An02g05750	Similarity: the ORF overlpas with A. niger EST an_1043 entry EMBLEST:BE760156.; Similarity: the predicted ORF is 162 amino acids longer at the C-terminus than the hypothetical protein SPAC30D11. 06c of S. pombe.; Title: strong similarity to hypothetical protein SPAC30D11.06c - Schizosaccharomyces pombe
An02g05760	Remark: glucan 1,4-alpha-glucosidase of S. cerevisiae has the EC number 3. 2. 1. 3.; Remark: the ORF shows strong similarity to EST an_3103 of A. niger. It has the database entry number EMBLEST:BE758851.; Similarity: additionally, the ORF overlaps with A. niger EST entry EMBLEST:BE759644.; Similarity: the blastp hits are mostly unspecific.; Title: weak similarity to glucan 1,4-alpha-glucosidase Muc1 - Saccharomyces cerevisiae
An02g05790	Title: strong similarity to hypothetical protein encoded by An09g03310 - Aspergillus niger
An02g05810	Remark: the ORF is questionable due to its short lenght of only 81 amino acids.; Title: questionable ORF
An02g05820	Remark: the ORF is questionable due to its short lenght of only 72 amino acids.; Title: questionable ORF
An02g05830	Catalytic activity: mannitol-1-phosphate 5-dehydrogenases convert D-mannitol 1-phosphate + NAD(+) <=> D-fructose 6-phosphate + NADH.; Function: mannitol-1-phosphate 5-dehydrogenase mtlD of S. mutans is acting as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS), which facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates.; Similarity: the ORF shows a weak homologues overlap with A. niger EST entry EMBLEST:BE760637 and strong similarity to PATENTDNA:AAF11255 EST SEQ ID NO:3778 as well as with PATENTDNA:AAF11568 EST SEQ ID NO:4091.; Title: strong similarity to mannitol-1-phosphate 5-dehydrogenase mtlD - Streptococcus mutans; See PMID 10878121
An02g05840	Catalytic activity: phaA of P. putida catalyses (3S)-3-hydroxyacyl-CoA <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: phaA of P. putida is involved in the the aerobic degradation of phenylacetic acid.; Title: strong similarity to enoyl CoA hydratase phaA - Pseudomonas putida
An02g05850	Function: ada2 of S. cerevisiae functions as adaptor for some transcriptional activation domains and thereby facilitates activation, probably by potentiating the activity of the transcriptional activator complex GAL4-VP16.; Phenotype: mutations in ada2 of S. cerevisiae reduced the activity of GAL4-VP16 and GCN4.; Remark: ada2 of S. cerevisiae is also called YDR448W, D9461. 33 or SWI8.; Title: strong similarity to transcription adaptor Ada2 - Saccharomyces cerevisiae; nucleus; See PMID 10490601
An02g05860	Function: dagA of D. discoideum is required for receptor and G protein-mediated activation of adenylyl cyclase.; Similarity: the ORF shows similarity to several serine/threonine protein kinases from different species with various function.; Title: strong similarity to rac-family serine/threonine protein kinase homolog dagA -Dictyostelium discoideum; deleted EC_number 2.7.1.37
An02g05870	Function: coatomer beta' subunit copB2 (p102) of H. sapiens is part of the Golgi coatomer complex necessary for membrane traffic in the constitutive exocytic pathway and retro-Golgi to ER transport by facilitating the formation of non-clathrin coated vesicles.; Remark: a putative frameshift due to an possible error at position 23672 (one bp too much) was corrected.; Title: strong similarity to coatomer beta subunit copB2 - Homo sapiens [putative frameshift]; cytoplasm; putative frameshift; See PMID 8334999
An02g05880	Catalytic activity: the NADH dehydrogenase from N. crassa converts NADH + ubiquinone <=> NAD(+) + ubiquinol.; Function: subunit of the bioenergetic enzyme complex NADH:ubiquinone reductase, which is involved in electron transfer from NADH to ubiquinone in the respiratory chain.; Induction: the level of the corresponding mRNA of the NADH dehydrogenase from N. crassa is increased 3-fold if cells are grown in the presence of chloramphenicol.; Similarity: the ORF overlaps with A. niger EST entry in PATENTDNA:AAF11473 EST SEQ ID NO:3996.; Title: strong similarity to 29.9 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1830489
An02g05890	Complex: protein disulfate isomerases are part of variuos enzymes with different functions, e. g. are active as beta subunit of prolyl 4-hydroxylases.; Function: pdi1 of C. elegans is facilitating the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures from maturating protein chains.; Similarity: the ORF show similarity to several protein disulfide-isomerases from different species.; Title: strong similarity to protein disulfide-isomerase pdi1 - Caenorhabditis elegans; endoplasmatic reticulum
An02g05900	Similarity: the ORF shows strong similarity to A. niger EST PATENTDNA: AAF11580 SEQ ID NO:4103.; Title: similarity to hypothetical protein AA57718.1 - Aspergillus nidulans
An02g05910	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g05920	Function: uga4 of S. cerevisiae additionally transports delta-aminolevulinic acid (ALA), another precursor of the porphyrin biosynthesis.; Function: uga4 of S. cerevisiae is the specific GABA transport protein of the yeast, in which additionally the amino acid permease (GAP1 gene) and the proline permease (PUT4 gene) exist.; Induction: the presence of GABA induces the expression of uga4 in S. cerevisiae; this induction is conferred by the 5' flanking region and requires the integrity of two positive regulatory proteins, the inducer-specific factor UGA3 and the pleiotropic factor UGA35/DURL/DAL81.; Remark: uga4 of S. cerevisiae is also called YDL210W or D1037.; Similarity: the ORF shows strong similarity to specialized amino acid and GABA transporters from several species, which belong both to the superfamily of choline transport proteins.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; plasma membrane; See PMID 2109179; See PMID 10713424
An02g05930	Title: strong similarity to hypothetical protein encoded by An16g01290 - Aspergillus niger
An02g06000	Title: strong similarity to gene expression regulator protein SEQ ID NO:119 from patent WO200257456-A2 - Unclassified organism; nucleus
An02g06010	Title: weak similarity to protein CARD-6 from patent WO200100826-A2 - Homo sapiens
An02g06020	Similarity: the ORF show much weaker similarity to several tetracycline efflux pumps from different species.; Title: strong similarity to hypothetical amine transporter SPCC18.02 - Schizosaccharomyces pombe
An02g06030	Catalytic activity: uaz of A. flavus converts urate + O(2) + H(2)O <=> 5-hydroxyxyisourate + H(2)O(2), and 5-hydroxyisourate decompose autocatalytically to form allantoin.; Function: uricase (urate oxidase) is the peroxisomal enzyme responsible for the degradation of the purine ring in urate into allantoin.; Remark: uaz of A. flavus is also called uox.; Title: strong similarity to urate oxidase uaz -Aspergillus flavus; peroxisome; See PMID 1339455
An02g06040	Similarity: the ORF shows also strong similarity to several ribosomal proteins L13 from different species with mitochondrial and cytoplasmic localization, which belongs to the same superfamily as L23, to the L13 family of ribosomal proteins.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L23 - Kluyveromyces lactis; See PMID 10743564
An02g06050	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S16.e - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921
An02g06060	Function: nrd1 of S. pombe is involved in blocking the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.; Phenotype: deletion of nrd1 IN S. pombe causes cells to initiate sexual development without nutrient starvation.; Title: similarity to RNA binding protein nrd1p -Schizosaccharomyces pombe
An02g06070	Function: crgA of M. circinelloides is involved in the regulation of carotenoid biosynthesis by light.; Similarity: the ORF shows similarity to RING finger proteins/transcription regulators from several species with diverse cellular function.; Title: strong similarity to carotenoid biosynthesis protein cgrA - Mucor circinelloide; See PMID 10651817
An02g06080	Phenotype: S. pombe ste20 mutants are methylamine-sensitive, exhibit enhanced medium acidification and are defective in the utilization of glycerol as a carbon source.; Remark: ste20 of S. pombe is also called ste16 or SPBC12C2. 02c.; Similarity: the ORF shows strong similarity another developmental protein, to piaA of D. discoideum, a regulator protein involved in chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase.; Title: strong similarity to sexual differentiation and meiosis protein ste20p - Schizosaccharomyces pombe; See PMID 10467002
An02g06090	Function: cellobiose dehydrogenase (CDH) is an enzyme produced under lignocellulose-degrading conditions by T. versicolor strain 52J (Tv) and several other wood-degrading fungi.; Similarity: the predicted ORF shows only weak similarity to the N-terminal part of cdh of T. versicolor,which is involved in heme binding; the C-terminal flavin domain is not homologues to the ORF.; Title: weak similarity to cellobiose dehydrogenase cdh - Trametes versicolor
An02g06110	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g06120	Catalytic activity: tyr1 of S. cerevisiae converts prephenate + NADP(+) <=> 4-hydroxyphenylpyruvate + CO(2) + NADPH.; Remark: alternate names for tyr1 of S. cerevisiae are YBR1218 or YBR166c.; Title: strong similarity to prephenate dehydrogenase Tyr1 - Saccharomyces cerevisiae
An02g06130	Remark: S14. e of N. crassa is also called crp-2.; Similarity: the ORF overlaps with A. niger ESTs an_3158, database entry EMBLEST:BE758901 and an_3216 EMBLEST:BE758954.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S14.e - Neurospora crassa; cytoplasm; See PMID 1977135
An02g06140	Function: it is assumed that the B. napus subsp. napus Sll3 S-locus protein Cepp is involved in self-incompatibility.; Similarity: the predicted ORF shows weak similarity to S-locus protein 3 SP3 of B. rapa.; Title: similarity to hypothetical S-locus protein Cepp - Brassica napus; See PMID 10471721; See PMID 10559445
An02g06150	Catalytic activity: bat2 of S. cerevisiae catalyses e. g. L-leucine + 2-oxoglutarate <=> 4-methyl-2-oxopentanoate + L-glutamate.; Phenotype: deletion of the gene for the cytosolic BAT2 of S. cerevisiae and the mitochondrial gene for bat1 resulted in an auxotrophy for branched-chain amino acids (Ile, Leu, and Val) and in a severe growth reduction on glucose-containing media, even after supply of these amino acids.; Remark: alternate names for bat2 of S. cerevisiae are J2209, YJR148w and TWT2.; Title: strong similarity to branched-chain amino acid aminotransferase Bat2 - Saccharomyces cerevisiae; See PMID 8798704
An02g06170	Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 118 amino acids long.; Title: questionable ORF
An02g06180	Function: nit-4 of N. crassa is a pathway-specific regulatory transcription activator, which is required for the expression of the structural genes for nitrate and nitrite reductase.; Similarity: The predicted ORF is 423 amino aids shorter at its C-terminus than nit-4 of N. crassa.; Similarity: the ORF shows similarity to some zinc finger transcription activators with various cellular function.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1840634
An02g06220	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAF06122.1 - Neurospora crassa
An02g06230	Complex: TFIIB binds directly to TBP, recruits RNA polymerase II, in part through an interaction with the small subunit of TFIIF.; Function: TFIIB is required for association of RNA polymerase II to the mRNA transcription initiation complex.; Function: TFIIB stabilizes TBP binding to the TATA element.; Remark: a splice site upstream of the START codon was detected.; Similarity: the predicted ORF shows strong similarity to TFIIB of several species.; Title: strong similarity to transcription initiation factor TFIIB - Kluyveromyces lactis; nucleus; See PMID 9519295; See PMID 8346020
An02g06240	Catalytic activity: ATP14 of S. cerevisiae catalyses the reaction ATP + H2O <=> ADP + phosphate.; Function: ATP14 of S. cerevisiae couples H+ transport via the inner mitochondrial membrane to ATP synthesis.; Phenotype: the ATP14 mutant of S. cerevisiae shows a high percentage of rho-cells arising spontaneously and no detectable oligomycin-sensitive ATPase activity.; Remark: ATP14 of S. cerevisiae is also called YLR295C or L8003. 20.; Similarity: the predicted ORF shows local identity with some A. niger ESTs, e. g. EMBLEST:BE760081.; Title: similarity to ATP synthase subunit h Atp14 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8702761; See PMID 11083870
An02g06280	Similarity: the predicted ORF shows local weak similarity to chitinase A of A. nidulans in the N-terminal region.; Similarity: the similarity of the predicted ORF to SPAC7D4. 03c of S. pombe is particularly strong in the central part of the molecule.; Title: strong similarity to hypothetical protein SPAC7D4.03c - Schizosaccharomyces pombe
An02g06290	Title: questionable ORF
An02g06300	Function: in human hydrolysis of the neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) by N-acetylated alpha-linked acidic dipeptidase (NAALADase) to release glutamate may be important in a number of neurodegenerative disorders in which excitotoxic mechanisms are implicated.; Similarity: the predicted A. niger protein shows similarity to several putative and known carboxypeptidase proteins.; Similarity: the predicted A. niger proteins is about 150-200 aminoacids longer at the N-terminus in comparison to similar proteins.; Title: similarity to naaladase II - Homo sapiens; See PMID 10085079
An02g06310	Title: questionable ORF
An02g06320	Catalytic activity: hydroxymethylglutaryl-CoA synthases convert (S)-3-hydroxy-3-methylglutaryl-CoA + CoA to acetyl-CoA + H2O + acetoacetyl-CoA.; Function: hmgs of S. cerevisiae condenses acetyl-CoA with acetoacetyl-CoA to form hmg-CoA, which is the substrate for hmg-CoA reductase.; Remark: alternative names for S. cerevisiae HMGS are YM4987. 09c and YML126c.; Title: strong similarity to 3-hydroxy-3-methylglutaryl-CoA synthase Erg13 -Saccharomyces cerevisiae; See PMID 2880580
An02g06330	Title: similarity to hypothetical protein B2I10.080 - Neurospora crassa
An02g06340	Title: similarity to hypothetical protein BAB76423.1 - Nostoc sp.
An02g06350	Function: pmc1 of S. cerevisiae pumps Ca2+ into the vacuole and participates in the control of the cytosolic free calcium together with atc1 protein.; Phenotype: mutations in calcineurin A or B subunits or the inhibitory compounds FK506 and cyclosporin A restore growth of pmc1 mutants in high Ca2+ media.; Remark: a putative sequencing error results in an frameshift.; Remark: alternate names for pmc1 of S. cerevisiae are G3749 or YGL006w.; Remark: the predicted ORF shows similarity with the A. nidulans EST AA784502.; Repression: the growth of S. cerevisae pmc1 mutants is inhibited by added Ca2+ only after activation of calcineurin.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae [putative frameshift]; vacuole; putative frameshift; See PMID 7507493
An02g06360	Complex: arc16 of H. sapiens belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc, p20-arc and p16-arc.; Function: arc16 of H. sapiens is part of a complex implicated in the control of actin polymerisation in cells.; Remark: a splice site was detected upstream of the START codon; Remark: synomys for arc16 of H. sapiens are p16-arc or arpC5 family protein.; Title: similarity to arp2/3 complex 16kD subunit arc16 - Homo sapiens; cytoskeleton; See PMID 9230079
An02g06370	Title: strong similarity to hypothetical protein B12F1.50 - Neurospora crassa
An02g06380	Function: N. crassa ro-2 mutations disrupted nuclear and vacuole distribution.; Remark: N. crassa ro-2 has independently been cloned twice with different N- and C-terminal sequences.; Remark: information concerning N. crassa ro-2 has only partially been published and additional information is avialable via http://www. fgsc. net/asil2000/invitedabs. htm.; Similarity: N. crassa ro-2 has independently been classified as p62 subunit of Arp1.; Similarity: N. crassa ro-2 originally has been classified as a novel 80 kDa protein that has two Cys-rich motifs which resemble zinc-binding LIM or RING domains thought to mediate protein-protein interactions as well as several potential binding sites for Src homology 3 (SH3) domains.; Title: strong similarity to RO2 - Neurospora crassa [putative frameshift]; putative frameshift; See PMID 9159520
An02g06390	Remark: RP30 is also called RPS7A or RPS30 or YOR096W or YOR3177W.; Remark: there are two genes for the ribosomal protein S7 in yeast.; Similarity: the predicted ORF is identical to the EMBLEST BE759339 of A. niger.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rp30 - Saccharomyces cerevisiae; cytoplasm; See PMID 1737755
An02g06400	Function: S. cerevisiae VPS21 encodes a rab5 like small GTPase that is involved in both the vacuolar protein sorting and the endocytic trafficking and mediates fusion of transport vesicles with the endosomal/prevacuolar compartment.; Remark: VPS21 of S. cerevisiae is also called YPT51 or O3154 or YOR089c or YOR3154c.; Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted ORF partially overlaps with the A. nidulans EMBLEST AA788364.; Title: strong similarity to small Ras-like GTPase Vps21 - Saccharomyces cerevisiae; endosome; See PMID 8586662
An02g06410	Remark: multiple short Exons of the genemodel suggest a questionable ORF, but the N-terminal region shows some similarity to type II secretion system protein gspE1 of Halobacterium sp.; Title: questionable ORF
An02g06420	Catalytic activity: acetate kinases convert ATP + acetate to ADP + acetyl phosphate.; Function: acetate kinases facilitate the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation.; Phenotype: the growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose,suggesting that the enzyme is also involved in excretion of excess carbohydrate.; Title: strong similarity to acetate kinase ackA -Escherichia coli; cytoplasm; See PMID 7883769; See PMID 8226682
An02g06430	Catalytic activity: transketolase catalyzes the reversible transfer of a two-carbon ketol unit to an aldose receptor, e. g. Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate.; Remark: the transketolase TKL1 of S. cerevisiae is also called YPR074C or YP9499. 29C.; Similarity: the predicted ORF shows strong similarity to the hypothetical transketolase SPBC24C6. 09c of S. pombe.; Title: similarity to transketolase Tkt1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8226984; See PMID 9924800
An02g06440	Function: rtm1 of S. cerevisiae confers resistance to the toxicity of molasse and might thus be a transporter involved in detoxification.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; plasma membrane; See PMID 7672593
An02g06450	Similarity: shows some similarity to several NADH dehydrogenase subunits.
An02g06460	Similarity: aminoacids 240 to 450 show some similarity to proteins of M. jannaschii and P. horikoshii.; Title: weak similarity to hypothetical protein MJ0147 - Methanococcus jannaschii
An02g06470	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An02g06500	Remark: dnaK proteins belong to the heat shock protein 70 family.; Similarity: the similarity of the predicted ORF to heat shock proteins of different spezies is restricted to the N-terminal region.; Title: similarity to dnaK-type molecular chaperone dnaK - Buchnera sp.
An02g06510	Similarity: shows similarity to central region of putative lipid transfer proteins of P. sativum and A. thaliana.; Title: weak similarity to hypothetical precursor of chloroplastic lipid transfer protein M30 - Pisum sativum
An02g06520	Catalytic activity: Na+ (in) + 2H+ (out) Na+ (out) + 2H+ (in).; Function: the Na+/H+ antiporter NapA of E. hirae can mediate sodium uptake when a transmembrane pH gradient is present.; Similarity: the predicted ORF shows similarity to Na+/H+ antiporters of several bacteria.; Title: strong similarity to Na+/H+ antiporter NapA -Enterococcus hirae; See PMID 9278382
An02g06530	Function: cluA of D. discoideum is supposed to act as a linker between motor molecules and mitochondria.; Phenotype: disruption of cluA in D. discoideum results in clustering of mitochondria near the cell center,in addition the mutants show a cytokinesis defect.; Similarity: the predicted ORF includes the EST BE758770 of A. niger.; Similarity: the predicted ORF shows strong similarity to proteins annotated as predicted EIF3 proteins of different spezies, this might be a database annotation error.; Title: strong similarity to protein required for dispersion of mitochondria cluA - Dictyostelium discoideum; See PMID 9150866
An02g06550	Catalytic activity: NADH + 2 Fe(3+) <=> NAD(+) + 2 Fe(2+).; Function: Fre1p of S. cerevisiae is required for the activity of the principal iron uptake system which utilizes a reductase activity that acts on ferric iron chelates external to the cell.; Remark: the ferric reductase FRE1 of S. cerevisiae is also called L8167. 2 or YLR214w.; Repression: mRNA levels of FRE1 from S. cerevisiae are repressed by iron.; Similarity: Fre1p of S. cerevisiae is about 100 amino acids longer at the N- and C-terminus.; Similarity: the predicted ORF shares similarities with several other putative ferric reductases, e. g. the gene product of cfl1 from C. albicans.; Title: similarity to ferric reductase Fre1 -Saccharomyces cerevisiae; plasma membrane; See PMID 1570306
An02g06560	Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Pathway: glutathione metabolism.; Remark: the isoJ gene from Rhodococcus sp. was overexpressed in Escherichia coli and was found to have activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1,2-epoxy-2-methyl-3-butene.; Similarity: belongs to the glutathione transferase family.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003
An02g06570	Remark: functional assays establish the ZFM1 protein as a transcriptional repressor. ZFM1 protein represses Gal4-GQC-mediated transcription, and this activity requires both a repression domain found in the N-terminal 137 amino acids of the protein, as well as a GQC interaction region.; Title: strong similarity to transcription factor ZFM1 - Homo sapiens; See PMID 9506990
An02g06580	Remark: AE2 anion exchangers from chicken are involved in the regulation of intracellular pH in each of these gastric epithelial cell types. In situ hybridization analyses have further revealed that AE2 transcripts accumulate to very high levels within the acid-secreting epithelial cells of the profound gland in the stomach and,to a lesser extent, within the mucus-secreting cells of the superficial gland that line the stomach lumen.; Similarity: belongs to the anion exchanger family.; Title: strong similarity to anion exchanger AE2-1 -Gallus gallus; See PMID 8621532; See PMID 11193604
An02g06590	Remark: GERp95 belongs to a family of highly conserved proteins in metazoans and Schizosaccharomyces pombe. It has recently been determined that plant and Drosophila homologues of GERp95 are important for controlling the differentiation of stem cells (Bohmert et al., 1998; Cox et al., 1998; Moussian et al., 1998).; Remark: GERp95 is a cytoplasmically exposed peripheral membrane protein that exists in a protease-resistant complex.; Remark: these proteins may exert their effects on cell differentiation from the level of intracellular membranes.; Title: strong similarity to Golgi ER protein 95 kDa GERp95 - Rattus norvegicus; See PMID 10512872
An02g06600	Remark: SPT7 from yeast is a histone acetyltransferase SAGA complex member transcription factor.; Remark: SPT7 plays an important role in transcription initiation in vivo.; Similarity: belongs to the unassigned bromodomain proteins.; Title: strong similarity to transcription factor Spt7 - Saccharomyces cerevisiae; See PMID 7713415; See PMID 1350857
An02g06610	Title: similarity to hypothetical protein SPAC11E3.10 - Schizosaccharomyces pombe
An02g06630	Catalytic activity: protein tyrosine phosphate + H2O = protein tyrosine + orthophosphate.; Remark: pyp2+ act as negative regulators of mitosis upstream of the wee1+/mik1+ pathway.; Remark: the pyp2 in fission yeast is about 150 amino acids longer, but the variability in length is great over different organisms.; Similarity: belongs to the tyrosine specific protein phosphatase and dual specificity protein phosphatase family.; Title: strong similarity to protein-tyrosine-phosphatase yp2p - Schizosaccharomyces pombe; See PMID 1448087; See PMID 1464319
An02g06660	Remark: putative serin threonin rich protein.
An02g06670	Remark: only a small domain matches with homologe proteins.; Title: weak similarity to regulator protein Snf5 -Saccharomyces cerevisiae
An02g06680	Remark: Pex19p in Pichia pastoris functions at an early stage of peroxisome biogenesis.; Remark: import of peroxisomal targeting signal 1-and 2-containing peroxisomal matrix proteins is defective in pex19 mutants.; Similarity: to pex19 proteins in different organisms such as S. cerevisiae, Homo sapines. .; Title: strong similarity to protein Pex19 - Pichia pastoris [truncated ORF]; See PMID 10051604; See PMID 10359594
An02g06700	Remark: mutations within the meaB gene elicit the inappropriate expression of several activities subject to nitrogen metabolite repression in Aspergillus nidulans and also have some unrelated phenotypic effects.; Title: strong similarity to nitrogen metabolite repression protein mEAB - Aspergillus nidulans; See PMID 8690087; See PMID 9352912
An02g06710	Remark: STM1 gene has been identified as a multicopy suppressor of mutations in several genes involved in mitosis (e. g. TOM1, MPT5, and POP2).; Title: strong similarity to suppressor of tom1 protein Mpt4 - Saccharomyces cerevisiae; See PMID 7548221; See PMID 10681538
An02g06720	Catalytic activity: L-glutamine + H2O = L-glutamate + NH3.; Pathway: glutamate metabolism; D-glutamine and D-glutamate metabolism; nitrogen metabolism.; Remark: also strong similarity to A. oryzae glutaminase protein patent WO9960104-A1.; Remark: purified glutaminase from A. oryzae catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Remark: the glutaminase from Neurospora crassa is approximately the same lenght as the predicted orf, whereas the homolog protein from A. oryzae is 200 amino acids shorter.; Remark: the purified glutaminase and determined partial amino-acid sequence can be used for enhancing taste particularly in glutamic acid-converting food processing to give e. g. seasoning sauces and pastes as well as other seasoning materials.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006
An02g06750	Remark: also strong similarity to DEADbox family protein 3 Homo sapiens patent WO9825145-A1.; Remark: proteins of the DEAD family of putative ATP-dependent RNA helicases have been implicated in translation initiation, ribosome assembly, and RNA processing in a variety of organisms from E. coli to man.; Similarity: belongs to the 'dead' box family helicase.; Title: strong similarity to DEAD box protein Dbp45A - Drosophila melanogaster; See PMID 7692973
An02g06760	Remark: RNA14 and RNA15 in yeast correlate with a reduction of mRNA stability and poly(A) tail length.; Remark: the yeast RNA14 is a component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing. interacts with fip1 and probably also with RNA15.; Title: similarity to mRNA 3-end processing protein Rna14 - Saccharomyces cerevisiae; See PMID 1674817
An02g06770	Remark: also strong similarity to wheat anti-silencing protein ASP from Triticum aestivum patent WO9955870-A2.; Remark: the phenotype suggested a role for ASF1 in DNA repair and chromosome maintenance.; Remark: yeast ASF1 overexpression weakens repression of genes near telomeres.; Title: strong similarity to anti-silencing function protein Asf1 - Saccharomyces cerevisiae; See PMID 9290207; See PMID 10759893
An02g06780	Remark: Sro7 function was believed to be the targeting of the myosin proteins to their intrinsic pathways, but nowadays more likely is its role in protein exocytosis, as it is implicated in docking and fusion of post-Golgi vesicles with the plasma membrane.; Remark: yeast SRO7 was identified as a multicopy suppressor of a defect in Rho3p, a small GTPase that maintains cell polarity.; Similarity: belongs to the lethal(2)giant protein family.; Title: strong similarity to suppressor of rho3 Sro7 - Saccharomyces cerevisiae; See PMID 9691031; See PMID 10402465
An02g06790	Title: weak similarity to hypothetical protein CAD60729.1 - Podospora anserina
An02g06810	Title: strong similarity to hypothetical protein YGL232w - Saccharomyces cerevisiae
An02g06820	Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Remark: PDC levels are a major determinant of ethanol production.; Similarity: belongs to the thiamine-diphosphate protein family.; Title: strong similarity to pyruvate decarboxylase pdcA - Aspergillus oryzae; putative sequencing error; See PMID 9210590
An02g06830	Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: the cellular integrity and response to hypoosmotic conditions in the yeast S. cerevisiae are ensured by a MAP kinase signal transduction pathway mediated by the yeast homolog of mammalian protein kinase C. Bck1p functions as the MAP kinase kinase kinase of this pathway.; Similarity: belongs to unassigned Ser/Thr or Tyr-specific protein kinases; shows protein kinase homology.; Title: similarity to MAP kinase kinase kinase KLBCK1 - Candida sphaerica; deleted EC_number 2.7.1.37; See PMID 10329146
An02g06840	Remark: SEC34 encodes a protein of 93-kD,peripherally associated with membranes. Fractionation of yeast cytosol indicates that Sec34p and Sec35p exist in an approximately 750-kD protein complex.; Title: strong similarity to vesicle tethering protein Sec34 - Saccharomyces cerevisiae; See PMID 10562277; See PMID 11292827
An02g06850	Title: similarity to hypothetical membrane protein YLR077w - Saccharomyces cerevisiae
An02g06860	Catalytic activity: L-glutamate = 4-aminobutanoate + CO2.; Pathway: glutamate metabolism; alanine and aspartate metabolism; beta-alanine metabolism; taurine and hypotaurine metabolism; butanoate metabolism.; Remark: also strong similarity to glutamate decarboxylase from mouse patent WO9214485-A.; Similarity: belongs to the family of human glutamate decarboxylases.; Title: strong similarity to glutamate decarboxylase 1 - Felis silvestris catus; See PMID 10331265; See PMID 3453123
An02g06870	Remark: RINT-1 human specifically binds to Rad50 only during late S and G(2)/M phases, suggesting that RINT-1 may be involved in cell cycle regulation.; Title: strong similarity to RAD50-interacting protein 1 RINT-1 - Homo sapiens; See PMID 11096100
An02g06890	Catalytic activity: ATP + deoxyribonucleotide(N) + deoxyribonucleotide(M) <=> AMP + diphosphate + deoxyribonucleotide(N+M); Function: Catalyses the formation of a phosphodiester at the site of a single strand break in duplex DNA.; Remark: RNA can also act as substrate to some extent.; Title: strong similarity to DNA ligase cdc17p -Schizosaccharomyces pombe
An02g06900	Title: strong similarity to hypothetical protein CAD60743.1 - Podospora anserina
An02g06910	Title: strong similarity to hypothetical membrane protein YIL108w - Saccharomyces cerevisiae
An02g06940	Title: similarity to transcription factor BOM - Mus musculus; nucleus; See PMID 12175488
An02g06950	Catalytic activity: hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.; Remark: STA1 of S. cerevisiae is also known as DEX2 and MAL5.; Title: weak similarity to glucan 1,4-alpha-glucosidase precursor Sta1 - Saccharomyces cerevisiae
An02g06960	Function: vacuolar protein sorting; Remark: Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.; Title: strong similarity to vacuolar assembly protein VPS41 - Lycopersicon esculentum; See PMID 7596406; See PMID 9159129
An02g06970	Title: similarity to hypothetical membrane protein YDR282c - Saccharomyces cerevisiae
An02g06980	Remark: The enzymatic properties including base specificity of RNase Trv were very similar to those of typical T2-family RNases such as RNase T2 from Aspergillus oryzae and RNase M from A. saitoi.; Title: similarity to ribonuclease TRV - Trichoderma viride; See PMID 1794979
An02g07000	Remark: recognizes a specific sequence in the promoter of the HO gene; found in nucleus in G1 but in cytoplasm in S, G2, and M phase of cell cycle; entry into nucleus is controlled during cell cycle by phosphorylation within the nuclear localization; sequence inhibited by Ash1p in daughter cells resulting in mother cell-specific HO expression; activation of HO gene requires Swi4p/Swi6p in addition to Swi5p; dephosphorylated by Cdc14p.; Title: similarity to transcription factor Swi5 -Saccharomyces cerevisiae; See PMID 3284746
An02g07010	Remark: a splice site was detected upstream of the START codon.; Remark: high homology to other polyubiquitin and CEP-80 genes at the N- and C-terminus; Remark: ubi1 of A. nidulans is a ubiquitin/ribosomal fusion protein.; Title: strong similarity to ubiquitin ubi1 -Aspergillus nidulans; cytoplasm; See PMID 10684969
An02g07020	Catalytic activity: Hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: Chitinase has been suggested to play a pivotal role in autolysis of the parasitic cell wall of Coccidioides immitis during the asexual reproductive cycle (endosporulation) of this systemic pathogen. Loss of CTS1 function had no effect on virulence or endosporulation. The absence of a functional CTS1 gene can be compensated for by elevated expression of the CTS2 gene.; Title: strong similarity to chitinase 1 precursor cts1 - Coccidioides immitis; See PMID 8566773; See PMID 10992492
An02g07040	Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Title: strong similarity to proteasome 20S subunit Scl1 - Saccharomyces cerevisiae; See PMID 9285707; See PMID 10582237; See PMID 187288
An02g07050	Remark: Homology is mainly based on repetitive sequences.; Title: weak similarity to hypothetical protein B0041.7 - Caenorhabditis elegans
An02g07060	Remark: Alp6 localizes to spindle pole body (SPB) and also to the equatorial microtubule organizing centre. Alp6 may play a crucial role in the spindle pole-mediated checkpoint pathway. temperature-sensitive (ts) alp4 and alp6 mutants show two types of microtubular defects.; Title: strong similarity to gamma-tubulin-interacting protein alp6p -Schizosaccharomyces pombe; See PMID 11080156
An02g07070	Remark: Atf1, and its binding site are necessary for the induction of ctt1(+) by osmotic stress, UV irradiation, and heat shock. Atf1 is activated by menadione treatment in pap1 mutant cells; Title: strong similarity to transcription factor atf1p - Schizosaccharomyces pombe; See PMID 8557039; See PMID 10102365; See PMID 10731689
An02g07080	Function: thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.; Remark: synonyms: prealbumin precursor; TBPA precursor.; Title: similarity to transthyretin precursor TTR -Rattus norvegicus; See PMID 3839240; See PMID 8246408; See PMID 1519447
An02g07090	Function: ASNA1 anion-transporting atpase catalyzes the extrusion of arsenite.; Title: strong similarity to ASNA1 product arsenite translocating ATPase - Homo sapiens; See PMID 8884272
An02g07110	Remark: a splice site was detected upstream of the START codon.
An02g07120	Function: binds to the 40s ribosome and promotes the binding of methionyl-tRNAi and mRNA.; Remark: Int-6 synonym: eukaryotic translation initiation factor 3 subunit 6.; Title: strong similarity to viral integration site protein int-6/EIF-3 P48 - Mus musculus; cytoplasm; See PMID 7853537
An02g07130	Title: similarity to hypothetical neighbour-of-FAU protein NOF1 - Homo sapiens; See PMID 8786148
An02g07140	Remark: Swi1p is component of the Swi/Snf chromatin remodelling complex.; Remark: the Swi/Snf complex includes Swi1p, Snf2p,Swi3p, Snf5p, Snf6p, Snf11p and other proteins.; Title: similarity to transcription regulator Swi1 -Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 7917331; See PMID 8939065; See PMID 3143101
An02g07150	Remark: ORF 5'truncated due to start of contig.; Similarity: the predicted A. niger protein shows similarity to several RNA-binding proteins.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens [truncated ORF]; See PMID 10668804
An02g07160	Catalytic activity: Maltose O-acetyltransferases catalyse the reaction, Acetyl-CoA + maltose <=> CoA + acetyl-maltose.; Function: E. coli maa acetylates glucose, maltose,mannose, galactose, and fructose in decreasing relative rates of 1, 0. 55, 0. 20, 0. 07 and 0. 04.; Remark: alternative names for E. coli maa are mac,b0459 and ylaD.; Similarity: E. coli maa belongs to the cyse/laca/lpxa/nodl family of acetyltransferases, composed of multiple repeats of [liv]-g-x(4).; Title: similarity to maltose O-acetyltransferase maa - Escherichia coli; See PMID 1856235
An02g07170	Similarity: N. crassa acr-2 is a Gal4 type transcription factor with a fungal Zn(2)Cys(6) DNA-binding domain.; Similarity: the predicted A. niger protein shows similarity to several Zn(2)Cys(6) DNA-binding domain containing proteins.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704
An02g07190	Function: A. niger tbpA is homologe to human TBP-7.; Gene-ID: tbpA; Remark: information about A. niger tbpA has not been published and is available via Swissprot and EMBL.; Similarity: A. niger tbpA belongs to the AAA family of ATPases.; Similarity: the predicted ORF is 64 amino acids longer than the A. niger tbpA protein sequence in the database, additionally three amino acids do not exactly match in the alignment.; See PMID 10664589
An02g07210	Function: the intracellular protease pepE is responsible for 68% of total intracellular proteolytic activity.; Gene-ID: pepE; Mapping: pepE from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 9309173.; See PMID 9266703
An02g07220	Remark: ORF classified questionable because according to patent Q87111 the DNA-region of this predicted A. niger ORF belongs to the 5'UTR of A. niger pepE.; Title: questionable ORF
An02g07230	Function: A. nidulans pod mutants have defects in establishing polar hyphal growth but are capable of nuclear division.; Function: a conditional mutation in pod40 from A. nidulans results in a polarity-defective phenotype.; Title: strong similarity to CTD phosphatase-like protein pod40 - Aspergillus nidulans; See PMID 11273680
An02g07250	Gene-ID: argA; Remark: by a BLASTX search argA from A. niger (EMBL: AF242315) was found: the ORF and argA from A. niger are identical in sequence, however, the ORF is N-terminal 23 amino acids longer and C-terminal 34.; Remark: depending on the growth conditions A. nidulans agaA transcripts have different 5'ends.; Similarity: the ORF is almost identical to A. nidulans arginase agaA.; See PMID 10547040; See PMID 9056996
An02g07260	Function: S. cerevisiae PET112 is nuclear encoded and seems to have a general function in mitochondrial gene expression, probably in translation.; Function: S. cerevisiae pet112 mutations lead to loss of mitochondrial DNA.; Function: the predicted A. niger protein, A. nidulans nempA and S. cerevisiae pet112 all show high similarity to bacterial glutamyl-tRNA amidotransferases.; Title: strong similarity to mitochondrial glutamyl-tRNA amidotransferase Pet112 - Saccharomyces cerevisiae; See PMID 8082172; See PMID 9287027
An02g07290	Title: weak similarity to hypothetical protein encoded by An11g05410 - Aspergillus niger
An02g07300	Title: strong similarity to hypothetical protein CAF05875.1 - Neurospora crassa
An02g07320	Catalytic activity: enoyl-CoA hydratases convert (3S)-3-hydroxyacyl-CoAc <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: enoyl-CoA hydratases are involved in fatty acid metabolism.; Function: the decribed function of H. sapiens AUH as AU-specific RNA-binding protein may indicate a role in mRNA degradation.; Remark: also acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4. 2. 1. 74).; Title: strong similarity to AU-specific RNA-binding protein / enoyl-CoA hydratase AUH - Homo sapiens
An02g07330	Title: similarity to hypothetical protein F17H10.1 -Caenorhabditis elegans
An02g07340	Title: similarity to hypothetical protein CAE76294.1 - Neurospora crassa
An02g07350	Title: weak similarity to hypothetical group 3 Lea protein MGL3 - Zea mays
An02g07360	Title: strong similarity to hypothetical protein B23L21.110 - Neurospora crassa
An02g07370	Title: similarity to hypothetical retinitis pigmentosa GTPase regulator-like protein - Takifugu rubripes retinitis
An02g07380	Title: strong similarity to myosin II heavy chain -Drosophila melanogaster; cytoskeleton
An02g07390	Title: strong similarity to essential protein #41 from patent WO2003076464-A2 - Aspergillus fumigatus
An02g07400	Title: strong similarity to nonhistone chromosomal protein Nhp6b - Saccharomyces cerevisiae; nucleus
An02g07420	Title: strong similarity to hypothetical protein B24B19.20 - Neurospora crassa
An02g07430	Function: homoserine dehydrogenases catalyze the NAD-dependent reduction of aspartate beta-semialdehyde into homoserine, which participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine.; Remark: the yeast enzyme acts most rapidly with NAD(+); Neurospora enzyme with NADP(+). Enzyme from E. coli is a multifunctional protein, which also acts as aspartate kinase (EC 2. 7. 2. 4).; Title: strong similarity to homoserine dehydrogenase YJR139c - Saccharomyces cerevisiae
An02g07440	Title: strong similarity to protein SEQ ID NO:7812 from patent WO200253728-A2 - Candida albicans
An02g07460	Title: strong similarity to hypothetical protein SPBC354.08c - Schizosaccharomyces pombe
An02g07470	Catalytic activity: D-fructose 1,6-bisphosphate <=> glycerone phosphate + D-glyceraldehyde 3-phosphate, the sixth step in glycolysis.; Remark: a splice site was detected upstream of the START codon.; Remark: also acts on (3S,4R)-ketose 1-phosphates. The enzyme increases electron-attraction by the carbonyl group, some (class I) forming a protonatedimine with it,others (class II), mainly of microbial origin, polarizing it with a metal ion, e. g. zinc.; Title: strong similarity to fructose-bisphosphate aldolase Fba1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1959676
An02g07480	Title: strong similarity to pheromone response pathway suppressor Srm1 - Saccharomyces cerevisiae
An02g07490	Remark: C-terminally truncated due to contig border.; Remark: the human USP21 gene is located on chromosome 1q21 and encodes a member of the ubiquitin-specific protease family with highly conserved Cys and His domains.; Title: similarity to NEDD8-specific protease USP21 -Homo sapiens [truncated ORF]; See PMID 10799498
An02g07500	Catalytic activity: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-lysine + 2-oxoglutarate + NADH.; Pathway: LYS1 from Candida albicans catalyzes the 8th step of the alpha-aminoadipate pathway of lysine biosynthesis.; Title: strong similarity to saccharopine dehydrogenase LYS1 - Candida albicans; See PMID 1429460; See PMID 7927784
An02g07510	Title: weak similarity to heavy neurofilament subunit NF-H - Rattus norvegicus
An02g07520	Title: weak similarity to hypothetical anthranilate synthase trpE - Bacillus halodurans
An02g07530	Remark: C-terminally truncated due to contig border.; Remark: PspA has been shown to be immunogenic in humans and therefore may have efficacy as a human vaccine.; Remark: PspA is a serologically variable protein of Streptococcus pneumoniae that has a surface-exposed domain and a variable-length proline-rich putative cell wall-associated domain.; Remark: Similarity to PspA is based mainly on the repetitive character of the sequence (PAPA stretches).; Title: similarity to pneumococcal surface protein A PspA - Streptococcus pneumoniae [truncated ORF]; cell wall; See PMID 10992499; See PMID 11015380
An02g07550	Title: similarity to hypothetical protein encoded by B9B15.005 - Neurospora crassa
An02g07560	Function: RTM1 of S. cerevisiae increased the resistance to the toxicity of molasses in the growth medium.; Title: strong similarity to molasses toxicity resisitance protein RTM1 from patent WO9514774-A2 -Saccharomyces cerevisiae
An02g07570	Function: KES1 of S. cerevisae plays a role in ergosterol synthesis.; Phenotype: mutations in the KES1 gene result in pleiotropic sterol-related phenotypes.; Remark: Kes1p of S. cerevisae consists of only the ligand binding domain.; Remark: inactivation of the KES1 gene resulted in the ability of yeast to survive in the absence of Sec14p,a phosphatidylinositol/phosphatidylcholine transfer protein that is normally required for cell viability due to its essential requirement in transporting vesicles from the Golgi.; Similarity: KES1 of S. cerevisae belongs to the OSBP (oxysterol binding protein) family.; Title: strong similarity to ergosterol biosynthesis protein Kes1 - Saccharomyces cerevisiae; See PMID 8017104
An02g07580	Function: CYHR of C. maltosa confers resistance to cycloheximide.; Localization: CYHR of C. maltosa is an integral membrane protein.; Remark: the ORF encoded protein also shows strong similarity to a protein involved in cephalosporin C biosynthesis of Acremonium chrysogenum (Patent W14439),which is only poorly described.; Similarity: CYHR of C. maltosa belongs to the car1/cyhr subfamily.; Similarity: CYHR of C. maltosa belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An02g07590	Function: nagA of S. thermoviolaceus hydrolyzes chitin oligosaccharides to N-acetylglucosamine.; Title: similarity to beta-N-Acetylglucosaminidase nagA - Streptomyces thermoviolaceus; See PMID 9687451
An02g07600	Catalytic activity: succinate + ubiquinone = fumarate + ubiquinol.; Complex: SDH1 of S. cerevisiae forms part of complex II containing four subunits: a 70 kda flavoprotein (FP), a 27 kda iron-sulfur protein (IP), a cytochrome b and a membrane-anchoring protein.; Localization: SDH1 of S. cerevisiae forms part of the mitochondrial inner membrane.; Pathway: SDH1 of S. cerevisiae is involved tricarboxylic acid cycle.; Remark: SDH1 of S. cerevisiae uses FAD as cofactor.; Remark: SDHA, YKL148C and YKL602 are alternative names for SDH1.; Similarity: SDH1 of S. cerevisiae shows similarity to the flavoprotein subunits of bacterial succinate dehydrogenase and of fumarate reductase.; Title: strong similarity to succinate dehydrogenase Sdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1511876; See PMID 1518827
An02g07610	Remark: strong similarity to A. niger EST from cDNA clone 2283 5' mRNA sequenc in pYES2.; Title: strong similarity to mannitol transporter mat1 - Apium graveolens; See PMID 10759540
An02g07630	Title: similarity to hypothetical c-module-binding factor - Neurospora crassa
An02g07640	Title: strong similarity to hypothetical protein CAF06119.1 - Neurospora crassa
An02g07650	Catalytic activity: alpha-D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate.; Catalytic activity: alpha-D-Hexose 1-phosphate = alpha-D-Hexose 6-phosphate.; Catalytic activity: alpha-D-Ribose 1-phosphate = alpha-D-Ribose 5-phosphate.; Remark: Transcription of pgmB was low during hyphal growth and in the sexual phase of development, but was significantly increased during the asexual stage of the Aspergillus nidulans life cycle.; Title: strong similarity to phosphoglucomutase pgmB - Aspergillus nidulans; See PMID 10660061
An02g07660	Remark: the ORF is longer than the StrI-related protein of D. radiodurans (535 compared to 403 amino acids).; Title: strong similarity to streptomycin biosynthesis protein StrI-related protein - Deinococcus radiodurans; See PMID 7845353
An02g07670	Remark: Similarity corresponds to multiple S-repeats.; Title: similarity to hypothetical protein K06A9.1a -Caenorhabditis elegans
An02g07690	Localization: Mal3 is a cytoplasmic protein that also associates with mitotic microtubule structures.; Remark: loss of the S. pombe mal3+ gene product had no gross effect on mitotic spindle morphology. overexpression of mal3+ compromised spindle formation and function and led to severe growth inhibition and abnormal cell morphology.; Similarity: the predicted A. niger protein shows strong similarity to the chromosome segregation protein Mal3 of S. pombe and EB-1 proteins from vertebrate species.; Title: strong similarity to chromosome segregation protein mal3p - Schizosaccharomyces pombe; See PMID 9348288
An02g07700	Function: the receptor subunit binds specifically to pIkappaBalpha and promotes its in vitro ubiquitination,thus allowing the pIkappaBalpha-ubiquitin ligase to mark proteins for degradation by the proteasome system.; Remark: the H. sapiens b-TRCP variant E3RS-IkappaB is a receptor component of IkappaBa-ubiquitin ligase.; Remark: the H. sapiens b-TRCP variant E3RS-IkappaB protein contains beta-transducin repeats, F-box and WD regions.; Title: similarity to b-TRCP variant E3RS-IkappaB -Homo sapiens; See PMID 9859996
An02g07710	Title: similarity to hypothetical protein encoded by Z2629 - Escherichia coli
An02g07720	Catalytic activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O.; Function: catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.; Pathway: first step in diaminopimelate and lysine biosynthesis.; Title: similarity to dihydrodipicolinate synthase dapA - Escherichia coli
An02g07730	Function: isoform 1 of ING1 from M. musculus inhibits p53-dependent transcriptional activation and may function as an oncoprotein.; Function: isoform 2 of ING1 from M. musculus acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.; Remark: 5'-truncated ORF due to end of contig.; Remark: ING1 from M. musculus contains 1 phd-finger domain.; Remark: ING1 from M. musculus is found in 2 isoforms produced by alternative splicing.; Remark: ING1 is widely expressed with highest levels in thymus and testis in the adult mouse.; Title: similarity to growth regulator ING1 - Mus musculus [truncated ORF]; See PMID 9440695; See PMID 10542254; See PMID 11461112; See PMID 9102209
An02g07740	Title: strong similarity to hypothetical protein SPAC1952.10c - Schizosaccharomyces pombe
An02g07750	Title: similarity to hypothetical protein SPAC2C4.08 - Schizosaccharomyces pombe
An02g07760	Title: similarity to hypothetical transcription regulator PAB1642 - Pyrococcus abyssi
An02g07770	Catalytic activity: trehalose synthase catalyzes the trehalose synthesis from alpha-D-glucose 1-phosphate and D-glucose.; Remark: TSase and TSase synthase are alternative names for trehalose synthase.; Title: strong similarity to trehalose synthase TSase - Grifola frondosa; See PMID 9763690
An02g07780	Function: ARFs are GTP-binding proteins that function as an allosteric activators of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. ARFs are involved in protein trafficking they may modulate vesicle budding and uncoating within the golgi apparatus.; Similarity: ARF6 of H. sapiens belongs to the ARF family of GTP-binding proteins.; Title: strong similarity to ADP-ribosylation factor 6 ARF6 - Homo sapiens; See PMID 1993656
An02g07790	Title: similarity to hypothetical protein B3E4.280 -Neurospora crassa
An02g07800	Remark: the ORF encoded protein also shows strong similarity to one of the proteins from patent Y34744, that represents the proteins encoded by all the open reading frames in the complete genome of Chlamydia pneumoniae.; Title: strong similarity to hypothetical protein CP0630 - Chlamydophila pneumoniae
An02g07810	Title: questionable ORF
An02g07830	Function: the PHD finger, is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation.; Similarity: the ORF encoded protein also shows similarity to several hypothetical and known phd finger transcription regulators; the region of similarity is restricted to the phd-domain.; Title: similarity to hypothetical phd finger transcription regulator - Schizosaccharomyces pombe; nucleus
An02g07840	Title: weak similarity to hypothetical protein encoded by An14g03700 - Aspergillus niger
An02g07850	Phenotype: Disruption strains showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Similarity: the ORF encoded protein also shows similarity to other hexose transporters.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An02g07860	Remark: a splice site was detected upstream of the START codon.; Remark: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: belongs to Zn[2]-Cys[6] fungal-type binuclear cluster proteins.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; nucleus; See PMID 9197408; See PMID 9524126; See PMID 10483720
An02g07870	Catalytic activity: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.; Pathway: arginine and proline metabolism.; Remark: prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline in collagens.; Remark: the recently identified peptide-binding domain showed a relatively low identity to those from other species, and the Km of the Drosophila enzyme for (Pro-Pro-Gly)10 was higher than that of any other animal prolyl 4-hydroxylase studied.; Title: similarity to prolyl-4-hydroxylase-alpha -Drosophila melanogaster; See PMID 10037780
An02g07880	Remark: QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5. The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880
An02g07890	Gene-ID: pacC; Mapping: pacC from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 8709960.; Remark: identical to pacC A. niger patent WO9925735-A1.; Remark: the Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; nucleus; See PMID 8602152
An02g07900	Remark: FKH2 S. cerevisiae, caused a form of yeast pseudohyphal growth.; Remark: Fkh2p assembles into ternary complexes with Mcm1p on both the SWI5 and CLB2 cell-cycle-regulated upstream activating sequence (UAS) elements in vitro, and in an Mcm1 p-dependent manner in vivo.; Remark: investigation of the relationship between Fkh2 and a related forkhead protein Fkh1 demonstrates that these proteins act in overlapping pathways to regulate cell morphology and cell separation.; Title: strong similarity to fork head 2 protein Fkh2 - Saccharomyces cerevisiae; See PMID 10747051; See PMID 10894548; See PMID 10899128; See PMID 10959837
An02g07910	Remark: SLG1 S. cerevisiae plays a regulatory role in bud emergence or stationary phase.; Title: similarity to hypothetical protein Slg1 -Saccharomyces cerevisiae; See PMID 8896276; See PMID 10660075
An02g07920	Title: weak similarity to hypothetical stringent starvation protein B PA4427 - Pseudomonas aeruginosa
An02g07930	Remark: linoleate diol synthase from Gaeumannomyces graminis is a homotetrameric ferric hemeprotein, which catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate. Ferryl intermediates and a tyrosyl radical are formed in the reaction.; Similarity: belongs to a gene family of fatty acid heme dioxygenases.; Title: strong similarity to precursor of linoleate diol synthase - Gaeumannomyces graminis; See PMID 10497176
An02g07940	Title: strong similarity to hypothetical protein YEL023c - Saccharomyces cerevisiae
An02g07950	Remark: shows similarity also to E. nidulans sterigmatocystin synthesis transcription regulator aflR.; Remark: the S. cerevisiae protein is a transcriptional activator, necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4).; Similarity: belongs to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 2109179
An02g07960	Remark: sterol glycosyltransferase (SGT) isolated from A. thaliana is used in a method to produce transgenic plants which have a better tolerance of/resistance against adverse environmental factors such as drought, high salt content of the soil, cold/frost and fungal attack using recombinant SGT.; Remark: strong similarity to A. thaliana protein containing sterol glycosyltransferase patent WO9817789-A1.; Title: strong similarity to sterol glycosyltransferase SGT from patent WO9817789-A1 -Arabidopsis thaliana
An02g07970	Remark: RTA1 from S. cerevisiae led to strong resistance to 7-aminocholesterol a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; See PMID 7672593
An02g07980	Remark: strong similarity to Microdochium nivale carbohydrate oxidase patent WO9931990-A1.; Remark: the M. nivale CHO oxidase has an oxidizing activity on maltotetraose which is at least twice as much as the oxidizing activity on glucose at a substrate concentration of 0. 83 mM. The CHO can oxidase the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e. g. preferentially oxidizing maltodextrins or cellodextrins over glucose.; Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale
An02g08000	Remark: heterotrimeric G proteins, consisting of alpha, beta, and gamma subunits, are implicated in major signal transduction pathways controlling a diversity of functions in eukaryotic organisms.; Remark: in the filamentous fungus Neurospora crassa,G proteins are implicated in the regulation of several environmental responses.; Similarity: belongs to the g-alpha family. belongs to subfamily 3 (g(q).; Title: strong similarity to G protein alpha chain Gna-1 - Neurospora crassa; See PMID 8325859
An02g08010	Remark: only serine rich proteins are matching.; Title: similarity to hypothetical serine-rich protein SPBC215.13 - Schizosaccharomyces pombe
An02g08020	Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Pathway: oxidative phosphorylation.; Remark: a group of enzymes from the plasma membranes of yeast and Neurospora. They are closely related to the H+/K+-transporting ATPases (EC 3. 6. 1. 36), have a single catalytic sub-unit (100 kDa) and form phosphoenyzme intermediates.; Title: strong similarity to H+-transporting ATPase lipid-binding protein vma3 - Neurospora crassa; See PMID 8190074
An02g08030	Remark: during the life cycle of P. infestans, ric1 was expressed in all developmental stages but the level of expression varied. Sporangia and germinating cysts appeared to contain only very little ric1 mRNA whereas in the mycelium and during in planta growth higher levels were detected. Subjecting the mycelium to osmotic stress or to a high pH resulted in increased ric1 expression.; Title: similarity to membrane spanning protein RIC1 - Phytophthora infestans; See PMID 10591972
An02g08040	Remark: only a serin threonin rich region is matching.
An02g08050	Title: similarity to hypothetical phosphatidyl synthase SPAC22A12.08c - Schizosaccharomyces pombe
An02g08060	Remark: no obvious phenotypes could be attributed to YGL144c.; Title: similarity to hypothetical protein YGL144c -Saccharomyces cerevisiae; See PMID 10806424
An02g08070	Remark: mutants exhibit RNase MRP RNA processing defect; functions redundantly with REX1 and REX2 in U5 snRNA and RNase P RNA processing.; Remark: the biogenesis of a number of RNA species in eukaryotic cells requires 3' processing.; Remark: the length to the REX3 protein is differnt but due to the similarity to other exonucleases the function seems clear.; Similarity: part of family of 3'- to 5' exonucleases.; Title: similarity to 3-5 exonuclease Rex3 -Saccharomyces cerevisiae; See PMID 10716935
An02g08080	Remark: X. laevis L22 mRNA is a example of the correlation between the polypyrimidine terminal tract and the translational regulation observed in other rp mRNAs.; Similarity: belongs to the ribosomal protein L22 protein family.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L22 - Xenopus laevis; cytoplasm; See PMID 7890164
An02g08090	Remark: Dim1p plays a role in mitotic spindle formation and/or function.; Remark: Dim1p strongly inhibits the pre-rRNA processing steps that lead to the synthesis of 18S rRNA.; Title: strong similarity to essential for mitosis protein dim1p - Schizosaccharomyces pombe; See PMID 9528805; See PMID 9182666
An02g08100	Function: translin is a recombination hotspot binding protein, which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.; Title: strong similarity to translin-like protein TRAX - Gallus gallus; See PMID 9244443; See PMID 9013868
An02g08110	Catalytic activity: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.; Function: may constitute a glutathionine peroxidase-like protective system against oxidative stresses.; Pathway: glutathione metabolism.; Remark: a protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1. 13. 11. 12 on phospholipids,can act as acceptor, but more slowly than H2O2.; Similarity: belongs to the glutathione peroxidase family.; Title: strong similarity to glutathione peroxidase Hyr1 - Saccharomyces cerevisiae; See PMID 10480913
An02g08130	Title: similarity to hypothetical protein 2SCG18.24 - Streptomyces coelicolor
An02g08140	Catalytic activity: protein tyrosine phosphate + H2O = protein tyrosine + orthophosphate.; Remark: CDC14 S. cerevisiae encodes a phosphotyrosine phosphatase (PTPase) and is essential for termination of M phase.; Similarity: belongs to the non-receptor class of the protein-tyrosine phosphatase family. cdc14 subfamily.; Title: strong similarity to protein-tyrosine-phosphatase Cdc14 - Saccharomyces cerevisiae; See PMID 10801456; See PMID 1597462; See PMID 8668128
An02g08160	Title: strong similarity to hypothetical protein PA2804 - Pseudomonas aeruginosa
An02g08170	Remark: also strong similarity to Penicillium decumbens epoxidation enzyme patent JP08322560-A.; Remark: the enzyme converts the phosphomycin precursor (z)-1-propenyl phosphonic acid into the antibiotic phosphomycin.; Title: strong similarity to epoxidase subunit A epoA - Penicillium decumbens; See PMID 10049860
An02g08180	Remark: GIT1 gene encodes a permease involved in the uptake of glycerophosphoinositol.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 9691030
An02g08190	Title: weak similarity to hypothetical membrane protein Upc2 - Saccharomyces cerevisiae; See PMID 9696767
An02g08200	Remark: there is also similarity to rape abscission/dehiscence protein Brassica napus patent WO9423043-A.; Similarity: belongs to ribitol dehydrogenase family and shows homology to short-chain alcohol dehydrogenase.; Title: similarity to developmental abscission/dehiscence protein SAC25 - Brassica napus; See PMID 8111020
An02g08210	Title: strong similarity to hypothetical protein EAA61130.1 - Aspergillus nidulans
An02g08220	Catalytic activity: 2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O.; Pathway: metabolic pathway for dissimilation of protocatechuate.; Remark: ligJ from Sphingomonas paucimobilis gene is essential to the degradation of vanillate and syringate.; Title: similarity to 4-oxalomesaconate hydratase ligJ - Sphingomonas paucimobilis; See PMID 11092855
An02g08230	Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679
An02g08240	Title: strong similarity to EST an_3059 -Aspergillus niger
An02g08250	Remark: putative cation efflux system protein.; Title: strong similarity to hypothetical protein F12L6.11 - Arabidopsis thaliana
An02g08260	Remark: Yox1 binding to the leucine tRNA gene is necessary for the in vivo regulation of the gene and its suggests that the YOX1 gene codes for a non-essential product.; Similarity: belongs to the family of homeobox proteins.; Title: similarity to homeotic protein Yox1 -Saccharomyces cerevisiae; See PMID 8096171
An02g08270	Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: acetylspermidine oxidase (ASOD) catalyzes the oxidation of N-acetylated spermidine in polyamine metabolism.; Similarity: belongs to the family of FAD-containing amine oxidases.; Title: strong similarity to acetylspermidine oxidase ASOD - Candida boidinii; See PMID 10913603
An02g08280	Remark: there is only homolgy to one element of DNA-directed RNA polymerase II large subunit in different orgenisms.; Title: weak similarity to DNA-directed RNA polymerase II large chain ama-1 - Caenorhabditis elegans; See PMID 2586513
An02g08290	Remark: according to PMID:10334994, the lovB gene encodes LNKS (14), containing the six domains characteristic of PKSs (Fig. 2), an integrated methyltransferase domain located between the AT and the KR domain, and a domain at the COOH-terminus that is similar to the condensation domain of nonribosomal peptide synthetases (NRPSs).; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 11386351
An02g08300	Title: strong similarity to hypothetical protein encoded by An11g06450 - Aspergillus niger
An02g08310	Remark: the LNKS and (at least) the LovC proteins interact to produce a polyketide of the correct length and with the correct reduction and cyclization pattern.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An02g08320	Remark: the protein is only the half of the length of PTH11.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; See PMID 10521529
An02g08330	Similarity: the ORF shows similarity to several multidrug-efflux transporters.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum
An02g08340	Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An02g08350	Title: strong similarity to hypothetical protein encoded by An16g00980 - Aspergillus niger
An02g08370	Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism.; Remark: MAO-N has the C-terminal tripeptide Ala-Arg-Leu, which corresponds to the consensus targeting sequence found in many peroxisomal enzymes.; Title: strong similarity to monoamine oxidase N mao-N - Aspergillus niger; See PMID 7727530; See PMID 7770050
An02g08380	Remark: alternative name is MSI2.; Remark: in S. cerevisiae the protein is a Gdp/GTP exchange factor required for growth at low temperatures. Under non-permissive conditions, more than 70% of the msi2 disruptants arrested at telophase as large budded cells with two nuclei divided completely and elongated spindles,indicating that the msi2 deletion is a cell division cycle mutation.; Title: strong similarity to guanine nucleotide-releasing factor Lte1 - Saccharomyces cerevisiae; See PMID 7941731; See PMID 7985422
An02g08390	Remark: the S. Pombe protein is approximately only the half of the lentgh, but all other homologies show only that there is myosin heavy chain anaologies which is also very long.; Title: similarity to hypothetical protein SPAC25B8.08 - Schizosaccharomyces pombe
An02g08400	Remark: all other homologies are to prolin rich proteins.; Title: similarity to hypothetical protein CAD70496.1 - Neurospora crassa
An02g08410	Remark: in Drosophila the locus where RN-tre is found produces a number of transcripts that accumulate ubiquitously during early embryogenesis but more specifically in the central nervous system during later stages.; Similarity: similar sequences have been identified in Arabidopsis thaliana, Caenorhabditis elegans, Homo sapiens, Mus musculus and S. cerevisiae.; Title: strong similarity to tre oncogene-related protein RN-tre - Drosophila melanogaster; See PMID 9512660
An02g08420	Remark: Aspergillus nidulans reproduces asexually via uninucleate, haploid spores, which are produced on morphologically differentiated aerial structures, called conidiophores. hymA is involved in budding processes, and is required for the formation of metulae and for their further differentiation.; Title: strong similarity to hypha-like metulae protein hymA - Aspergillus nidulans; See PMID 8969518; See PMID 9928930
An02g08430	Remark: PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.; Remark: methylation is one of the many post-translational modifications that modulate protein function.; Title: strong similarity to protein arginine N-methyltransferase 3 PRMT3 - Rattus norvegicus; See PMID 9642256
An02g08440	Remark: the Blastn match against entry EMBL:AF263922 (A. niger NsfA gene) arise from additional, not annotated DNA sequences next to the NsfA gene in this EMBL-entry.; Title: strong similarity to hypothetical protein CAD70331.1 - Neurospora crassa
An02g08445	Remark: the similarity is restricted to the very N-terminus of the matching protein.; Title: weak similarity to essential protein #664 from patent WO200286090-A2 - Aspergillus fumigatus
An02g08450	Gene-ID: nsfA; Remark: strong similarity to Sec18 S. cerevisiae. SEC18 gene function is required for secretory protein transport between the endoplasmic reticulum (ER) and the Golgi complex.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Remark: there is no publication for the A. niger genproduct available.
An02g08460	Remark: most of the blastp matches are unspecific.; Title: weak similarity to hypothetical protein F17L21.7 - Arabidopsis thaliana
An02g08470	Title: similarity to hypothetical protein YGL079w -Saccharomyces cerevisiae
An02g08490	Function: barA of E. coli could activate ompR by phosphorylation.; Function: over-expression of barA of E. coli suppresses a defect in ompC and ompF expression.; Similarity: barA of E. coli shows similarity to other prokaryotic sensory transduction histidine kinases.; Title: similarity to sensor-regulator protein barA -Escherichia coli; See PMID 1574005; See PMID 7957084
An02g08510	Title: similarity to sensor/regulator protein RpfA -Erwinia carotovora
An02g08520	Catalytic activity: allantoate + H(2)O = (-)-ureidoglycolate + urea.; Remark: also hydrolyses (+)-ureidoglycolate to glyoxylate and urea.; Title: strong similarity to allantoicase alc -Neurospora crassa; See PMID 2148685
An02g08540	Similarity: patentmatch against protein AC W12703 Geneseqprot.; Title: weak similarity to 2-5A-dependent RNase from patent WO9639806-A1 - Mus musculus
An02g08560	Title: similarity to hypothetical dioxygenase SCOEDB - Streptomyces coelicolor
An02g08570	Remark: the annotated ORF shows also strong similarity to the A. niger EST an_2771.; Title: strong similarity to isopenicillin N acyltransferase aAT - Aspergillus nidulans; See PMID 7847890; See PMID 2120195; See PMID 2166227
An02g08580	Similarity: similarities correspond to multiple serine-repeats.; Title: weak similarity to hypothetical serine-rich repeat protein - Schizosaccharomyces pombe
An02g08590	Function: after binding acetylcholine, the homolog from X. laevis achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.; Title: strong similarity to hypothetical cytochrom B561 related protein CAD70500.1 - Neurospora crassa
An02g08600	Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).; Remark: mature SerZMm homolog protein overexpressed in E. coli efficiently aminoacylated bacterial tRNA(Ser) in vitro.; Title: strong similarity to mitochondrial serine--tRNA ligase serS - Zea mays; localisation:mitochondrion; See PMID 9747857
An02g08610	Title: strong similarity to hypothetical protein CAD21038.1 - Neurospora crassa
An02g08620	Remark: disruption of the acr-2 gene in N. crassa lead to progenies that were hypersensitive to acriflavine.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa
An02g08630	Title: strong similarity to phosphoinositide dependent protein kinase-1 PDK1 - Homo sapiens
An02g08640	Similarity: similarities correspond to multiple serine-repeats.; Title: weak similarity to hypothetical membrane protein YMR317w - Saccharomyces cerevisiae
An02g08650	Title: strong similarity to EST AN07D07 -Aspergillus niger
An02g08660	Title: strong similarity to hypothetical protein H04M03.4 - Caenorhabditis elegans
An02g08670	Title: strong similarity to hypothetical phosphate/phosphoenolpyruvate translocator protein At2g25520 - Arabidopsis thaliana
An02g08680	Title: strong similarity to hypothetical protein CAD70306.1 - Neurospora crassa
An02g08690	Title: strong similarity to galactose permease Gal2 - Saccharomyces cerevisiae; See PMID 2666404; See PMID 2697639
An02g08700	Complex: human TFIIIB related factor hBRF is part of the TBP-containing complex 0. 38M-TFIIIB.; Function: the human 0. 38M-TFIIIB complex is required for transcription of the adenovirus type 2 VAI gene.; Title: strong similarity to TFIIIB related factor hBRF - Homo sapiens; See PMID 8943358
An02g08710	Remark: The transposable element Tan1 of Aspergillus niger var. awamori is a member of the Fot1 family.; Remark: This ORF has 31 stop codons.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8625427; See PMID 9003286
An02g08720	Title: strong similarity to copper resistance-associated P-type ATPase CRP1 - Candida albicans; See PMID 10737803
An02g08730	Title: strong similarity to hypothetical protein SPCC4G3.05c - Schizosaccharomyces pombe
An02g08750	Catalytic activity: the A. eutrophus UDPglucose 4-epimerase converts UDP-glucose to UDP-galactose.; Title: strong similarity to hypothetical UDP-glucose 4-epimerase - Alcaligenes eutrophus; See PMID 7851418
An02g08760	Title: similarity to apoptosis associated protein #11 from patent WO200102550-A2 - Candida albicans
An02g08770	Title: weak similarity to hypothetical protein AAN36506.1 - Plasmodium falciparum
An02g08780	Title: similarity to hypothetical protein B7F18.110 - Neurospora crassa
An02g08790	Title: similarity to hypothetical protein B7F18.120 - Neurospora crassa
An02g08800	Title: similarity to hypothetical protein CIP1 -Candida sp.
An02g08810	Similarity: just strong repetitive similarities.
An02g08820	Title: strong similarity to hypothetical protein SPBC31F10.16 - Schizosaccharomyces pombe
An02g08830	Title: similarity to hypothetical protein SPBC31F10.14c - Schizosaccharomyces pombe
An02g08840	Title: similarity to rabkinesin-6 - Mus musculus; See PMID 9438855
An02g08845	Title: strong similarity to hypothetical protein CAD60765.1 - Podospora anserina
An02g08850	Function: Ubc4 of S. cerevisiae is involved in heat shock response and turnover of short-lived proteins.; Function: Ubc4 of S. cerevisiae is one of several ubiquitin-conjugating enzymes that attach posttranslational ubiquitin to proteins.; Remark: Ubiquitin conjugating enzymes are involved in rapid and highly selective protein degradation.; Remark: Ubiquitin conjugating enzymes are involved in the regulation by degradation in many different cellular pathways.; Title: strong similarity to ubiquitin conjugating enzyme Ubc4 - Saccharomyces cerevisiae; See PMID 2154373
An02g08860	Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca
An02g08870	Title: strong similarity to hypothetical protein SPCC4G3.09c - Schizosaccharomyces pombe
An02g08880	Title: similarity to hypothetical protein PFB0705w -Plasmodium falciparum
An02g08900	Title: strong similarity to protein precursor Bcs1 -Saccharomyces cerevisiae
An02g08910	Title: strong similarity to hypothetical protein SC5C7.08 - Streptomyces coelicolor
An02g08920	Function: CCT3 is required for microtubule and actin function in vivo.; Title: strong similarity to TCP1-related protein Cct3 - Saccharomyces cerevisiae; See PMID 7916460
An02g08930	Title: strong similarity to hypothetical protein FLJ13902 - Homo sapiens
An02g08940	Title: similarity to hypothetical ubiquitin-conjugating enzyme At2g16920 - Arabidopsis thaliana
An02g08950	Title: weak similarity to hypothetical protein B0041.7 - Caenorhabditis elegans
An02g08960	Title: questionable ORF
An02g08970	Remark: S. cerevisiae cells expressing Tpo1 become resistant to polyamine toxicity,the resistance was overcome by bafilomycin A1, an inhibitor of vacuolar H+-ATPase.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows also similarity to a protein involved in cephalosporin C biosynthesis of patent JP09009966-A, but its function is not clearly enough described.; Title: similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; See PMID 9920864
An02g08980	Cofactor: FAD.; Function: amadoriases are a novel class of FAD enzymes which catalyze the oxidative deglycation of glycated amino acids to yield corresponding amino acids,glucosone, and H(2)O(2).; Remark: alternate name for amadoriase II A. fumigatus: fructosyl amine:oxygen oxidoreductase.; Similarity: the ORF encoded protein shows also strong similarity to the amadoriase from Aspergillus terreus described in patent JP10033180-A.; Title: strong similarity to amadoriase II -Aspergillus fumigatus; See PMID 9139700; See PMID 10684633
An02g08990	Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to eukaryotic initiation factor 4B Eif4B - Triticum aestivum; See PMID 10600500
An02g09000	Similarity: the similarities of the ORF encoded protein to all other proteins are mainly based on repetitive structures.; Title: weak similarity to dentin sialophosphoprotein DSPP - Homo sapiens
An02g09010	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens
An02g09020	Complex: Sds3p (S. cerevisiae) is an integral subunit of the high molecular weight Rpd3p/Sin3p containing yeast histone deacetylase complex (transcriptional repression).; Function: the S. cerevisae Sds3 protein is involved in transcriptional silencing at the HMR locus and telomeres.; Remark: alternate name for S. cerevisiae Sds3: YIL084c.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical protein B2O8. 340 from Neurospora crassa, which is related to nif-specific regulatory protein from Rhizobium leguminosarum,PIR:S06965.; Title: similarity to component of the yeast histone deacetylase complex Sds3 - Saccharomyces cerevisiae; nucleus; See PMID 8978024; See PMID 10655212; See PMID 11024051
An02g09030	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.
An02g09040	Title: strong similarity to EST g7c08a1.r1 -Aspergillus nidulans
An02g09050	Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178
An02g09060	Similarity: the ORF encoded protein shows similarity/weak similarity to the many known and hypothetical protein kinases.; Title: similarity to disease associated protein kinase DAPK-3 from patent WO9858052-A2 - Homo sapiens
An02g09070	Title: weak similarity to precursor of alpha/beta-gliadin - Triticum aestivum
An02g09080	Similarity: the similarities of the ORF encoded protein to all other proteins are mainly based on repetitive structures.; Title: weak similarity to dentin sialophosphoprotein DSPP - Homo sapiens
An02g09090	Catalytic activity: alpha-D-glucose <=> beta-D-glucose.; Remark: alternate names for mutarotase enzyme: mutarotase or aldose mutarotase.; Similarity: the ORF encoded protein shows also strong similarity to the characterized aldose 1-epimerase mro from Acinetobacter calcoaceticus (Pubmed 3012466).; Title: strong similarity to mutarotase enzyme from patent JP07039380-A - Sus scrofa
An02g09100	Function: the Act2 protein from S. cerevisiae plays an important role in nuclear pore complex (NPC) structure and function.; Similarity: the ORF encoded protein shows strong similarity to the actin-related protein RO7, required for nuclear localization and proper localization of cytoplasmic dynein and dynactin in Neurospora crassa (still unpublished).; Title: similarity to actin-like protein Act2 -Saccharomyces cerevisiae; See PMID 9218799; See PMID 1729653
An02g09120	Remark: the ORF belongs to a retrotransposon-like sequence found also in other contigs.; Remark: the tobacco retrotransposon Tto1 is one of the few active retrotransposons of plants.; Title: strong similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum; See PMID 8624443
An02g09150	Remark: the ORF encoded protein partly contains repetitive structures.; Title: similarity to structure specific nuclease 5 from patent WO9823774-A - Unclassified organism
An02g09160	Title: strong similarity to hypothetical protein YOR311c - Saccharomyces cerevisiae
An02g09170	Function: Spb4p from S. cerevisiae (an essential putative RNA helicase) is required for a late step in the assembly of 60S ribosomal subunits.; Remark: alternate name for S. cerevisiae Spb4: YFL002C.; Title: strong similarity to ATP dependent RNA helicase Spb4 - Saccharomyces cerevisiae; nucleus; See PMID 8774901; See PMID 9769101
An02g09180	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from S. cerevisiae and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An02g09190	Remark: alternate name for S. cerevisiae MRPS28: YDR337w.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S15 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2263452
An02g09200	Function: the S. cerevisiae Yst1 protein binds DNA. it is required for the assembly and/or stability of the 40S ribosomal subunit.; Remark: the C. albicans CaYst1 protein complements the lethality of a yst1 null mutation in S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the S. cervisiae Yst1 protein; Title: strong similarity to translational factor CaYST1 - Candida albicans; See PMID 9579059
An02g09210	Remark: alternate name for S. cerevisiae Rho2: YNL090W.; Title: similarity to GTP-binding protein Rho2 -Saccharomyces cerevisiae; See PMID 9038344; See PMID 9405296; See PMID 1441750
An02g09220	Catalytic activity: tRNA uridine <=> tRNA pseudouridine.; Function: the Deg1 product from S. cerevisiae is responsible for the formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of tRNAs.; Localization: Deg1p (S. cer.) localizes both in the nucleus and in the cytoplasm.; Remark: alternate names for S. cerevisiae Deg1: Pus3, YFL001W.; Title: strong similarity to pseudouridine synthase Deg1 - Saccharomyces cerevisiae; nucleus; See PMID 9430663
An02g09230	Title: similarity to glycosylphosphatidylinositol anchor class H biosynthesis protein GPI-H - Homo sapiens; See PMID 8054538; See PMID 8407896
An02g09240	Catalytic activity: ATP + D-ribose 5-phosphate <=> AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Remark: alternate name for S. cerevisiae Prs5: YOL061W.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prs5 - Saccharomyces cerevisiae; See PMID 9829955
An02g09250	Function: the vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. The Vma6 subunit from S. cerevisiae is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector.; Title: strong similarity to subunit of the vacuolar ATPase Vma6 - Saccharomyces cerevisiae; vacuole; See PMID 8509410
An02g09260	Complex: the S. cerevisiae Nop5 protein interacts with Nop1.; Function: S. cerevisiae Nop5 is required for pre-18S rRNA processing.; Remark: alternate names for S. cerevisiae Nop5: Nop58 or YOR310C.; Title: strong similarity to nucleolar protein Nop5 -Saccharomyces cerevisiae; nucleus; See PMID 9632712
An02g09270	Catalytic activity: Cellobiose + O(2) <=> cellobiono-1,5-lactone + H(2)O(2).; Cofactor: Flavoprotein; Heme.; Function: the cellobiose dehydrogenase (oxidase) (CBDH) is secreted by the soft-rot thermophilic fungus Humicola insolens during growth on cellulose.; Remark: alternate EC 1. 1. 99. 18.; Title: strong similarity to cellobiose dehydrogenase CBDH - Humicola insolens; extracellular/secretion proteins; See PMID 9461557; See PMID 9920875
An02g09280	Similarity: the similarities of the ORF encoded protein to RPGR from B. taurus and to other proteins are only based on repetitive structures.; Title: similarity to retinitis pigmentosa GTPase regulator RPGR - Bos taurus; See PMID 10932196
An02g09300	Title: strong similarity to hypothetical protein CAD21172.1 - Neurospora crassa
An02g09310	Remark: alternate names for the human stomatin protein: EPB72,BND7 or erythrocyte band 7 integral membrane protein.; Remark: defects in EPB72 in red blood cells of patients with hereditary stomatocytosis or cryohydrocytosis results in an increased Na+/K+-permeability and hence to a disorder of cell volume control.; Similarity: the ORF encoded protein shows also strong similarity to the human protein described in patent WO9925825-A2.; Title: strong similarity to erythrocyte membrane protein stomatin - Homo sapiens; See PMID 7592848; See PMID 8825639; See PMID 1547348
An02g09330	Remark: N-terminally truncated ORF due to the end of contig.; Title: weak similarity to S-phase kinase associated protein p45Skp2 from patent WO9711176-A2 - Homo sapiens [truncated ORF]
An02g09340	Similarity: the ORF encoded protein shows also weak similarity chitinase ChiA from Emericella nidulans (Pubmed 9501518).; Title: weak similarity to TRK2 protein fragment from patent WO9909151-A2 - Lycopersicon esculentum
An02g09350	Remark: the cDNA of the sulfate transport protein 2 (shst2) from Stylosanthes hamata has been isolated by complementation of a yeast mutant.; Title: strong similarity to sulfate transport protein shst2 - Stylosanthes hamata; See PMID 7568135
An02g09370	Complex: the human eIF2 translation initiation factor is a heterotrimer composed of an alpha, a beta, and a gamma chain.; Function: the human eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40s ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with gIF by way of a reaction catalyzed by eIF-2b.; Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to translation initiation factor eIF-2 alpha chain EIF2A - Homo sapiens [truncated ORF]; cytoplasm; See PMID 1748310; See PMID 2948954
An02g09380	Title: questionable ORF
An02g09390	Function: the murine Trp6 protein is a nonselective capacitative calcium entry channel subunit. It mediates calcium entry stimulated by a G-protein coupled receptor but not by intracellular calcium store depletion. It becomes activated by diacylglycerol (DAG) in a membrane-delimited fashion independently of protein kinase C. It is permeable for calcium, cesium, sodium, potassium and magnesium.; Remark: TREMBL:SCYOR089C_2 is not S. cerevisiae YOR089c/Vps21. It is identical to a truncated YOR088c protein.; Similarity: only the C-terminal part of the ORF encoded protein shows strong similarity to the S. cerevisiae hypothetical protein YOR088c. The N-terminal part of the ORF encoded protein is similar to the complete peptide sequence of the hypothetical protein YOR087w from S. cerevisiae. The ORF encoded protein can not be divided into two separate ORFs.; Similarity: the ORF DNA sequence shows strong similarity the EST an_1965 from Aspergillus niger.; Title: similarity to capacitative calcium entry channel Trp6 - Mus musculus; plasma membrane; See PMID 9368034
An02g09420	Function: TRI4 from F. sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: alternate name for Fusarium sporotrichioides TRI4: CYP58.; Similarity: TRI4 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An02g09430	Remark: FUM5 from Gibberella fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: Fumonisins are toxins associated with several mycotoxicoses and are produced by the maize pathogen Gibberella fujikuroi mating population A (MP-A).; Remark: a putative frameshift results in an premature STOP codon.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis [putative frameshift]; putative frameshift; See PMID 10413619; See PMID 11238987
An02g09440	Remark: ankyrin repeats are believed to mediate protein-protein interactions.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster; See PMID 7937942
An02g09460	Complex: S. cerevisiae Pep7 (Vac1) genetically and physically interacts with the activated, GTP-bound form of Vps21, a Rab GTPase that functions in Golgi-to-endosome transport, and with Vps45.; Function: S. cerevisiae Pep7 is required for the transport of the Golgi-precursors of the soluble hydrolases carboxypeptidase Y, proteinase A, and proteinase B to the endosome. Pep7 functions in a vesicle consumption step in vesicle-mediated transport of soluble hydrolases to the endosome.; Remark: alternate names for S. cerevisiae Pep7: Vac1, Vpl21, Vps19, Vpt19 or YDR323C.; Title: strong similarity to vacuolar segregation protein Pep7 - Saccharomyces cerevisiae; See PMID 9168472; See PMID 10021387
An02g09470	Function: Spf1 (Cod1) was discouvered to be involved in the control of HMG-CoA reductase degradation. spf1 mutants show resistance to the killer toxin SMKT. A functional characterization about its P-type ATPase function is not published yet.; Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Spf1: Cod1 or YEL031W.; Similarity: S. cerevisiae Spf1 and the ORF encoded protein belong to the cation transport ATPases family (E1-E2 ATPases); subfamily V.; Title: strong similarity to hypothetical Ca2+-transporting ATPase Spf1 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10361284; See PMID 10704442
An02g09480	Function: Spf1 (Cod1) was discouvered to be involved in the control of HMG-CoA reductase degradation. spf1 mutants show resistance to the killer toxin SMKT. A functional characterization about its P-type ATPase function is not published yet.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Spf1: Cod1 or YEL031W.; Similarity: S. cerevisiae Spf1 and the ORF encoded protein belong to the cation transport ATPases family (E1-E2 ATPases); subfamily V.; Title: strong similarity to hypothetical Ca2+-transporting ATPase Spf1 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10361284; See PMID 10704442
An02g09500	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An02g09530	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An02g09540	Function: Hnm1 from S. cerevisiae is responsible for the yeast choline import. A mutant displays a phenotype only when the internal choline biosynthesis is destroyed (cho1-mutants).; Remark: alternate names for S. cerevisiae Hnm1: Ctr1, Ctr or YGL077C.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 1878995
An02g09550	Function: disruption of het-c2 gene from Podospora anserina drastically impairs ascospore production in homozygous crosses, and some mutants exhibit abnormal branching of apical hyphae. the protein encoded by het-c2 is essential in the biology of the fungus and may be involved in cell-wall biosynthesis.; Similarity: the ORF encoded protein and the het-c2 protein from Podospora anserina are also similar to the pig glycolipid transfer protein, GTLP.; Title: strong similarity to protein het-c2 -Podospora anserina; See PMID 8016091
An02g09560	Similarity: the ORF encoded protein shows strongest similarity to the unpublished human protein LRP16.; Title: strong similarity to protein regulating gene expression PRGE-6 from patent WO9964596-A2 - Homo sapiens; nucleus
An02g09610	Protein sequence is in conflict with the conceptual translation; Function: N. crassa WC-1 is a transcription factor involved in light regulation. It binds and affects blue light regulation of the AL-3 gene.; Similarity: the ORF encoded protein shows also exclusively very strong similarity to the E. nidulans NsdD gene product.; Similarity: the ORF encoded protein, WC-1 from N. crassa and NsdD from E. nidulans belong to the GATA-type transcription factor family.; Title: similarity to zinc-finger transcription factor WC-1 - Neurospora crassa; nucleus; putative frameshift; See PMID 9009271
An02g09690	Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: TFL I is a trimer enzyme.; Similarity: belongs to the carboxylesterases type-B family.; Title: strong similarity to lipase I precursor TFLI - Geotrichum fermentans; See PMID 9228786
An02g09720	Catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine.; Pathway: glutamate metabolism; glutathione metabolism.; Remark: a DNA fragment encoding gamma-glutamylcysteine synthetase [EC 6. 3. 2. 2] of Schizosaccharomyces pombe was cloned by complementation of the cadmium hypersensitivity of a S. pombe mutant deficient in the enzyme.; Title: strong similarity to gamma-glutamylcysteine synthase gcs1p - Schizosaccharomyces pombe; See PMID 7608113; See PMID 8619315
An02g09730	Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Pathway: ubiquinone biosynthesis; oxidative phosphorylation.; Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 4828 patent EP1033405-A2.; Remark: the homologues human protein was earlier proposed to be a cell adhesion protein.; Remark: the predicted ORF is 22 amino acids shorter at the N- and C-terminus than the CI-B18 chain of NADH:ubiquinone reductase from B. taurus.; Similarity: the ORF shows similarity to several ubiquinone oxidoreductases.; Title: similarity to 18 kD subunit of NADH:ubiquinone reductase CI-B18 - Bos taurus; See PMID 1518044
An02g09740	Remark: in the fission yeast S. pombe, the 'start' of the cell cycle is controlled by the two functionally redundant transcriptional regulator complexes, Res1p-Cdc10p and Res2p-Cdc10p, that activate genes essential for the onset and progression of S phase.; Remark: res2+ in fission yeast is largely redundant in function with res1+ and is required for the initiation of mitotic and premeiotic DNA synthesis, but has an additional role in meiotic division. unlike res1+, res2+ is highly induced during conjugation and strongly depends on cdc10+ for its activity.; Title: strong similarity to cell cycle regulator res2p - Schizosaccharomyces pombe; See PMID 8168485; See PMID 10982385
An02g09780	Remark: S. cerevisiae normally will not take up sterols from the environment under aerobic conditions. A specific mutant, upc2-1, of the predicted transcriptional activator UPC2 (YDR213w) has been recognized as a strain that allows a high level of aerobic sterol uptake.; Remark: alternative name is YDR213w.; Similarity: to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 11208779
An02g09790	Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 38506 patent EP1033405-A2.; Remark: strong similarity to EST SEQ ID NO:4038 from Aspergillus niger.; Remark: the predicted ORF is a putative amino acid permease.; Similarity: to choline transport proteins.; Title: strong similarity to protein fragment SEQ ID NO:38506 from patent EP1033405-A2 - Arabidopsis thaliana
An02g09810	Catalytic activity: NADPH + NAD+ = NADP+ + NADH.; Function: the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane.; Pathway: nicotinate and nicotinamide metabolism.; Remark: a splice site upstream of the START codon was detected.; Remark: similarity to EST an_2187 from Aspergillus niger.; Remark: the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase is a homodimer of monomer Mr = 109,228. Hydropathy analysis of its cDNA-deduced amino acid sequence (1043 residues) has indicated that the molecule is composed of 3 domains: a 430-residue-long hydrophilic N-terminal domain which binds NAD(H), a 200-residue-long hydrophilic C-terminal domain which binds NADP(H), and a 400-residue-long hydrophobic central domain which appears to be made up mainly of about 14 hydrophobic clusters of approximately 20 residues each.; Similarity: to E. coli transhydrogenase alpha- and beta-subunit and to alanine dehydrogenases.; Title: strong similarity to mitochondrial nicotinamide nucleotide transhydrogenase NNTM - Bos taurus; See PMID 3277960; See PMID 2005110
An02g09820	Remark: the ORF is short in length (54 amino acids).
An02g09860	Remark: the ORF has an unusual exon/intron structure for A. niger.
An02g09870	Title: questionable ORF
An02g09890	Title: strong similarity to EST an_2336 -Aspergillus niger
An02g09910	Remark: FEN1 S. cerevisiae is involved in the synthesis of 1,3-beta-glucan, a component of the cell wall,and elongation of fatty acids up to 24 carbons .; Title: strong similarity to fatty acid elongase Fen1 - Saccharomyces cerevisiae; See PMID 9211877
An02g09930	Catalytic activity: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.; Pathway: oxidative phosphorylation.; Remark: Cytochrome c oxidase (CcO) in S. cerevisiae is subject to intricate physiological control. Growth phase, carbon source, and oxygen level are three well recognized modulators of CcO expression.; Remark: strong similarity to EST an_2060 from Aspergillus niger.; Similarity: to mammalian cytochrome-c oxidase chain Va.; Title: strong similarity to subunit VI of cytochrome c oxidase Cox6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6210289; See PMID 6290493; See PMID 2537949
An02g09940	Catalytic activity: transfers an alpha-D-mannosyl residue from GDPmannose into lipid--linked oligosaccharide,forming an alpha-1,2-D-mannosyl-D-mannose linkage.; Pathway: glycoprotein biosynthesis.; Remark: KTR1 S. cerevisiae utilizes mannose,methyl-alpha-mannoside, alpha-1,2-mannobiose and methyl-alpha-1,2-mannobiose, as well as Man15-30GlcNAc,derived from mnn2 mutant glycoproteins, as substrates. It did not utilize alpha-1,6-mannobiose, alpha-1,6-mannotriose, alpha-1,6-mannotetraose, mammalian Man9GlcNAc or yeast Man9-10GlcNAc.; Remark: glycosylation constitutes one of the most important of all the post-translational modifications and may have numerous effects on the function, structure,physical properties and targeting of particular proteins. Eukaryotic glycan structures are progressively elaborated in the secretory pathway. Following the addition of a core N-linked carbohydrate in the endoplasmic reticulum,glycoproteins move to the Golgi complex where the elongation of O-linked sugar chains and processing of complex N-linked oligosaccharide structures take place.; Similarity: belongs to the; Title: strong similarity to alpha-1,2-mannosyltransferase Ktr1 - Saccharomyces cerevisiae; See PMID 8631921; See PMID 9020857; See PMID 9878809
An02g09950	Remark: GCP3 colocalizes with gamma-tubulin at the centrosome, cosediment with gamma-tubulin in sucrose gradients, and coimmunoprecipitate with gamma-tubulin,indicating that they are part of the gamma-tubulin complex. The yeast spindle pole body and the animal centrosome share a common molecular mechanism for microtubule nucleation.; Title: similarity to spindle pole body protein spc98 homolog GCP3 - Homo sapiens; See PMID 9566967
An02g09960	Catalytic activity: ATP + 5'-phosphoribosyl-N-formylglycinamide + L-glutamine + H2O = ADP + orthophosphate + 5'-phosphoribosyl-N-formylglycinamidine + L-glutamate.; Pathway: purine metabolism.; Remark: Escherichia coli 5'-phosphoribosylformylglycinamide (FGAR) amidotransferase (EC 6. 3. 5. 3) encoded by the purL gene catalyzes the conversion of FGAR to formylglycinamidine in the presence of glutamine and ATP for the de novo purine nucleotide biosynthesis.; Similarity: belongs to the phosphoribosylformylglycinamidine synthase family.; Title: strong similarity to phosphoribosylformylglycinamidine synthase purL -Escherichia coli; See PMID 2531746; See PMID 2659070
An02g09970	Function: might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: strong similarity to A. chrysogenum cephalosporin C biosynthesis protein patent JP09009966-A.; Similarity: to multidrug transporters of diverse fungal species.; Title: strong similarity to cephalosporin C biosynthesis protein from patent JP09009966-A - Acremonium chrysogenum
An02g09980	Title: similarity to hypothetical protein encoded by An01g14410 - Aspergillus niger
An02g09990	Similarity: the N-terminus of the ORF shows local similarity to zinc-finger containing transcription factors.; Title: weak similarity to CYC1/CYP3 transcription activator Hap1 - Saccharomyces cerevisiae; See PMID 2851658; See PMID 2643482
An02g10000	Catalytic activity: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.; Function: use of phenylalanine and phenylacetate as a carbon source.; Induction: by phenylacetate (PhOAc), 2OH-PhOAc,3OH-PhOAc, 4OH-PhOAc, phenylalanine, and tyrosine.; Induction: not induced by acetate or glutamate.; Pathway: last step in the metabolism of tyrosine.; Remark: N-terminal truncated ORF due to end of contig.; Remark: disruption of the fah gene results in phenylalanine toxicity, secretion of succinylacetone and the absence of growth. This is analogous to the genetic disease, type I hereditary tyrosinaemia (ht1) in humans.; Repression: expression is partially repressed by glucose.; Title: strong similarity to fumarylacetoacetate hydrolase fahA - Aspergillus nidulans [truncated ORF]; See PMID 7568087
An02g10010	Function: D. buzzatii Osvaldo pol codes for a putative protease (PR), a reverse transcriptase/ribonuclease H (RT/RH), a integrase (IN), and a significant portion of the surface envelope (ENV) protein.; Remark: the predicted A. niger protein contains two possible sequencing errors at position 31867 and 32236.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of, which is 700 aa longer.; Title: similarity to retrotransposon Osvaldo gene pol - Drosophila buzzatii [putative pseudogene]; putative pseudogene; See PMID 10406108
An02g10020	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An02g10030	Title: weak similarity to hypothetical protein encoded by An08g11120 - Aspergillus niger
An02g10040	Catalytic activity: cinnamyl-alcohol dehydrogenases convert cinnamyl alcohol + NADP(+) to cinnamaldehyde + NADPH.; Function: E. gunnii CAD1 catalyses the conversion of p-hydroxy-cinnamaldehydes to the corresponding alcohols and is considered a key enzyme in lignin biosynthesis.; Function: E. gunnii CAD1 exhibits high affinity towards lignin precursors including 4-coumaraldehyde and coniferaldehyde, but does not accept sinapaldehyde, and recombinant CAD 1 can also utilize a wide range of aromatic substrates including unsubstituted and substituted benzaldehydes.; Title: strong similarity to cinnamyl alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508
An02g10050	Remark: Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: contains a zn(2)-cys(6), fungal-type binuclear cluster domain.; Title: similarity to transcription activator thi1p -Schizosaccharomyces pombe; nucleus; See PMID 8088540
An02g10060	Title: weak similarity to regulator of beta-1,3-glucan synthase Hkr1 - Saccharomyces cerevisiae; See PMID 8113191; See PMID 8550469
An02g10080	Function: F. oxysporum P450foxy catalyzes the subterminal (-1 to -3) hydroxylation of fatty acids.; Function: the physiological roles of the terminal hydroxylation of fatty acids including those of F. oxysporum P450foxy are essentially unknown.; Localization: native F. oxysporum P450foxy was exclusively recovered in the membrane fraction of the fungal cells.; Remark: F. oxysporum P450foxy is a unique cytochrome P450 in that it is self-sufficient, which means that it can complete its function without the aid of other proteinaceous components such as NADPH-cytochrome P450 oxidoreductase (referred to as P450reductase).; Remark: N- and C-terminal homologies respectively suggest that F. oxysporum P450foxy is a fused protein of P450 and its reductase.; Remark: the Exon-Intron structure in the C-terminal region of the predicted A. niger protein is in accordance with the A. niger ESTs an_1826 and 1715.; Similarity: F. oxysporum P450foxy belongs to the CYP505 group of cytochrome P450s.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of F. oxysporum P450foxy, which is 600 aa longer.; Title: similarity to fatty-acid subterminal hydroxylase P450foxy - Fusarium oxysporum; See PMID 10995755
An02g10090	Title: strong similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger
An02g10100	Localization: ER-localisation was determined by cytoimmunofluorescence studies using epitope-tagged mouse EP58.; Title: similarity to endoplasmic reticulum protein EP58 - Mus musculus; endoplasmatic reticulum; See PMID 11167020
An02g10110	Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to ATP-binding cassette transporter abc1p - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; See PMID 9037770
An02g10120	Title: similarity to hypothetical protein encoded by An07g01070 - Aspergillus niger
An02g10140	Similarity: to proteins involved in non-ribosomal protein biosynthesis and polyketide synthesis.; Title: strong similarity to o peptide-polyketide synthase McyG - Microcystis aeruginosa; See PMID 11033079
An02g10150	Title: similarity to hypothetical dehydratase/racemase - Rhodococcus erythropolis
An02g10160	Catalytic activity: L-kynurenine + 2-oxoglutarate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate; Cofactor: Pyridoxal-phosphate.; Remark: Also acts on 3-hydroxykynurenine.; Title: strong similarity to kynurenine aminotransferase - Rattus sp.; See PMID 7926014
An02g10170	Remark: Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. MCT3 is the major MCT isoform responsible for efflux of glycolytically derived lactic acid from white skeletal muscle.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638
An02g10180	Remark: The cut9 gene encodes a 78-kD protein containing the 10 34-amino acid repeats, tetratricopeptide repeats (TPR), and is similar to budding yeast Cdc16.; Title: strong similarity to anaphase control protein cut9p - Schizosaccharomyces pombe; See PMID 7798319
An02g10190	Title: strong similarity to hypothetical protein BAB14757.1 - Homo sapiens
An02g10200	Remark: TRRAP is an essential cofactor for the tanscription factors c-Myc and E2F.; Title: strong similarity to protein TRRAP - Homo sapiens; See PMID 9708738
An02g10210	Title: strong similarity to protein phosphatase PP2A0 B subunit gamma isoform - Oryctolagus cuniculus; See PMID 8576224
An02g10220	Remark: human transcription factor IIIC (hTFIIIC) is a multisubunit complex that mediates transcription of class III genes through direct recognition of promoters (for tRNA and virus-associated RNA genes) or promoter-TFIIIA complexes (for the 5S RNA gene) and subsequent recruitment of TFIIIB and RNA polymerase III.; Title: similarity to transcription factor IIIC63 -Homo sapiens; See PMID 10373544
An02g10230	Title: similarity to hypothetical protein CAD11786.1 - Neurospora crassa
An02g10250	Title: weak similarity to hypothetical reverse transcriptase - Glomerella cingulata
An02g10260	Remark: Fission yeast genes nda1 and nda4, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.; Title: strong similarity to cell division protein nda4p - Schizosaccharomyces pombe; See PMID 8298187
An02g10270	Complex: S. cerevisiae Vps52p, Vps53p, and Vps54p are associated in a 1:1:1 complex.; Function: Vps52p, Vps53p, and Vps54p are required for the retrograde transport of Golgi membrane proteins from an endosomal/prevacuolar compartment.; Golgi; Phenotype: S. cerevisiae LUV1 mutants lack a morphologically intact vacuole and instead accumulate small vesicles that are acidified and contain the vacuolar proteins alkaline phosphatase and carboxypeptidase Y and the vacuolar membrane H(+)-ATPase.; Remark: alternative gene names for S. cerevisiae VPS54 are YDR027C, LUV1, RKI1 or TCS3.; Similarity: the ORF overlaps with the A. niger EST an_3009 (EMBLEST:BE758766).; Title: strong similarity to protein involved in vacuolar protein sorting Vps54 - Saccharomyces cerevisiae; See PMID 10888679
An02g10280	Remark: the ORF is short in length (89 amino acids).
An02g10290	Remark: the ORF has an unusual exon/intron structure for A. niger.
An02g10300	Remark: the ORF has short length (97 amino acids).
An02g10310	Function: the glycogen synthase of N. crassa synthesizes starch (glycogen) by addition of glucose moieties.; Pathway: the glycogen synthase of N. crassa is involved in glycogen biosynthesis.; Remark: the glycogen synthase of N. crassa belongs to the mammalian/fungal glycogen synthase family.; Remark: the glycogen synthase of N. crassa is inactivated at 45 degrees, thus glycogen accumulation shifts to trehalose accumulation.; Similarity: the ORF overlaps with the A. niger EST an_2027 at it's C-terminus.; Title: strong similarity to glycogen synthase -Neurospora crassa; See PMID 8549797
An02g10320	Induction: expression of the nmt1 gene of A. parasiticus is inhibited by thiamine (2. 0 microM).; Remark: nmt1 of A. parasiticus belongs to the nmt1 family.; Remark: nmt1 of A. parasiticus is presumably involved in the thiamine biosynthesis (vitamine B1).; Similarity: the ORF overlaps with the A. niger EST an_0381 at it's C-terminus.; Similarity: the ORF overlaps with the A. niger patent WO200056762-A2 at it's C-terminus.; Similarity: the ORF shows strong similarity also to other proteins involved in thiamine/pyrimidine biosynthesis.; Title: strong similarity to protein nmt1 -Aspergillus parasiticus; See PMID 7711083
An02g10330	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An02g10340	Remark: the ORF has a - for A. niger - long intron (295 nucleotides).
An02g10350	Function: the FPPS protein of G. fujikuroi is a key enzyme in isoprenoid biosynthesis.; Induction: the FPPS protein of G. fujikuroi is not regulated by light induction.; Remark: the FPPS polypeptide chain from G. fujikuroi carries two activities: a dimethylallyltranstransferase (EC: 2. 5. 1. 1) and a geranyltranstransferase (EC: 2. 5. 1. 10) activity.; Title: strong similarity to farnesyl-pyrophosphate synthase FPPS - Gibberella fujikuroi; See PMID 8753652
An02g10360	Complex: CDC23 is a component of the APC (anaphase-promoting complex).; Function: CDC23 of S. cerevisiae is required for cell cycle progression through the G2/M transition.; Function: CDC23 of S. cerevisiae is required for chromosome segregation.; Remark: the APC plays a key role in the regulation of mitosis by triggering the separation of sister chromatids at the metaphase-anaphase transition.; Similarity: 90 N-terminal amino acids of the ORF are not homologous to CDC23 of S. cerevisiae; the alignment of the two proteins includes five extended gaps.; Title: strong similarity to cell division control protein Cdc23 - Saccharomyces cerevisiae; nucleus; See PMID 8423787
An02g10370	Function: DNA ligases IV ligate DNA and thereby hydrolyze ATP.; Function: DNA ligases IV presumably function in V(D)J recombination and non-homologous end-joining of DNA double-strand breaks.; Remark: DNA ligase IV of H. sapiens belongs to the ATP-dependent DNA ligase family.; Remark: a putative sequencing error results in an frameshift.; Similarity: the ORF is C-terminally 190 amino acids longer than lig4 of H. sapiens; the two proteins are aligned until amino acid 652.; Similarity: the similarity of the ORF to the hypothetical protein 15E6. 90 of N. crassa is much higher than to known DNA ligases.; Title: similarity to DNA ligase IV lig4 - Homo sapiens [putative frameshift]; nucleus; putative frameshift; See PMID 7760816; See PMID 9363683; See PMID 9539976
An02g10380	Complex: SAP 61 of H. sapiens is part of the heterotrimeric splicing factor SF3a together with SAP 62,and 114.; Function: spliceosome-associated proteins are involved in pre-mRNA splicing.; Function: spliceosome-associated proteins are required for U2 snRNP binding to the pre-mRNA.; Remark: SAP 61 of H. sapiens is associated with pre-mRNA in spliceosomal complexes and with U2 snRNP.; Title: strong similarity to spliceosome-associated protein SAP61 - Homo sapiens; nucleus; See PMID 8022796
An02g10390	Complex: eukaryotic translation initiation factors 4A function as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome (cap recognition).; Function: eukaryotic translation initiation factors 4A are ATP-dependent RNA helicases.; Function: eukaryotic translation initiation factors 4A unwind secondary structure in the 5'-untranslated region of mRNA,; Function: eukaryotic translation initiation factors' 4A activity is a prerequisite for mRNA binding to ribosomes.; Remark: eIF-4A II of M. musculus is differently high expressed in various organs.; Remark: eukaryotic translation initiation factors 4A belong to the 'DEAD' box family of helicases.; Similarity: the ORF has ca. 100 C-terminal additional amino acids, not found in eIF-4AII of M. musculus and other species.; Title: strong similarity to eukaryotic translation initiation factor eIF-4A II - Mus musculus; See PMID 11333019; See PMID 11418588; See PMID 3046931
An02g10400	Similarity: similarity is restricted to C-terminus of the protein.; Title: strong similarity to GTP-binding associated protein #28 from patent WO200105970-A2 - Homo sapiens
An02g10410	Remark: possible sequencing error.; Title: strong similarity to EST an_3055 -Aspergillus niger [putative frameshift]
An02g10420	Title: strong similarity to hypothetical protein CAB91439.2 - Neurospora crassa
An02g10430	Title: questionable ORF
An02g10440	Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Function: the vacuolar ATPase generates an acidic interior and drives the transport of small molecules in vacuoles, storing large amounts of phosphate and basic amino acids.; Remark: the vacuolar ATPase is a large enzyme,composed of 8-10 subunits that are arranged into two sectors, a complex consisting of peripheral subunits (V1) and an integral membrane complex (V0).; Remark: the vma-1 gene of N. crassa encodes the largest, non-integral catalytic subunit of the active enzyme.; Title: strong similarity to H+-transporting ATPase vma-1 - Neurospora crassa; vacuole; See PMID 8722770; See PMID 1400281; See PMID 1491233; See PMID 2142943; See PMID 2971651
An02g10450	Function: VPS1 binds microtubules and could also be involved in microtubule-associated motility.; Function: VPS1 interacts with the mvp1 protein.; Function: the VPS1 protein (vacuolar sorting protein 1) of S. cerevisiae is essential for protein sorting in meiotic cell division.; Function: the VPS1 protein is necessary for membrane protein retention in a late golgi compartment.; Golgi; Similarity: belongs to the dynamin family.; Title: strong similarity to GTP-binding protein Vps1 - Saccharomyces cerevisiae; See PMID 9372190
An02g10460	Remark: the Nitrilase family contains hydrolases that break carbon-nitrogen bond and appear to be involved in the reduction of organic nitrogen compounds and ammonia production.; Similarity: contains Carbon-nitrogen hydrolase Pfam domain.; Similarity: similarity to nitrilases.; Title: similarity to protein fragment SEQ ID NO:63238 from patent EP1033405-A2 - Arabidopsis thaliana
An02g10470	Similarity: similarity to esterases and lipases (EC 3. 1. 1. - and 2. 3. 1. -) involved in metabolism of vitamins, co-factors, lipids and fatty-acids.; Title: similarity to protein fragment SEQ ID NO:22341 from patent EP1033405-A2 - Arabidopsis thaliana
An02g10480	Catalytic activity: 2 RH + 2 chloride + H(2)O(2) = 2 RCl + 2 H(2)O.; Function: catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione), the enzyme also has potent catalase activity and in the absence of halide ion,acts as a peroxidase similar to plant peroxidases.; Remark: brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds.; Title: similarity to chloride peroxidase cpo -Leptoxyphium fumago; See PMID 3771564
An02g10490	Catalytic activity: endohydrolysis of 1,3- or 1,4-linkages in beta-d-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.; Title: strong similarity to endo-1,3(4)-beta-glucanase bg1 - Phaffia rhodozyma; plasma membrane
An02g10500	Similarity: weak similarity (partial) to Guanylate kinase (E. C. 2. 7. 4. 8) S. cerevisiae.
An02g10550	Catalytic activity: endohydrolysis of 1,5-alpha-l-arabinofuranosidic linkages in 1,5-arabinans.; Function: the prefered substrate of A. niger ABN A protein is linear 1,5-alpha-l-arabinan, the enzyme activity is progressively reduced as 1,5-alpha-chains become shorter or more highly substituted.; Induction: by l-araban, arabinogalactan and l-arabitol.; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; Similarity: belongs to family 43 of glycosyl hydrolases.; Title: strong similarity to endo-alpha-1,5-arabinanase abnA - Aspergillus niger; plasma membrane; See PMID 7764386; See PMID 8000538
An02g10560	Similarity: contains ankyrin repeat domain.; Similarity: similarity is restricted to C-terminus of Murine protein kinase/ankyrin homologue SEQ ID no:334.; Title: similarity to protein kinase/ankyrin homologue SEQ ID NO:334 from patent WO9955865-A1 - Mus musculus
An02g10570	Title: questionable ORF
An02g10580	Title: similarity to hypothetical protein CAD21354.1 - Neurospora crassa
An02g10610	Similarity: similarity is restricted to C-terminus.; Title: weak similarity to hypothetical protein Cj0814 - Campylobacter jejuni
An02g10620	Similarity: similarity corresponds to multiple alanine repeats.; Similarity: weak similarity to putative secreted protein SC4A7. 11 - Streptomyces coelicolor.
An02g10630	Similarity: contains ATP/GTP-binding site motif A (P-loop).; Title: strong similarity to hypothetical protein encoded by An08g09830 - Aspergillus niger
An02g10640	Similarity: only partial similarity.; Title: weak similarity to hypothetical protein CAB55016.2 - Caenorhabditis elegans
An02g10660	Function: the beta subunit of H. sapiens methionine adenosyltransferase MATII has regulatory function.; Remark: Methionine adenosyltransferase (MAT; S-adenosyl-L-methionine synthetase, EC 2. 5. 1. 6)1 is an essential enzyme that catalyzes the synthesis of S-adenosylmethionine (AdoMet) from L-methionine (L-Met) and ATP, the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.; Remark: the H. sapiens methionine adenosyltransferase consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit.; Title: strong similarity to methionine adenosyltransferase regulatory beta subunit MAT II - Homo sapiens; cytoplasm; See PMID 10644686
An02g10670	Catalytic activity: (R)-Lactate + 2 Ferricytochrome c = Pyruvat + 2 Ferrocytochrome c.; Similarity: no N-terminal similarity.; Title: strong similarity to protein D-lactate dehydrogenase YEL071w - Saccharomyces cerevisiae; See PMID 10509019
An02g10680	Catalytic activity: estradiol-17-beta + NAD(+) = estrone + NADH.; Complex: homodimer.; Function: favors the reduction of estrogens and androgens, also has 20-alpha-hsd activity, uses preferentially NADH.; Localization: cytoplasmic.; Pathway: biosynthesis of estrogens.; Similarity: belongs to the short-chain dehydrogenases/reductases family (sdr).; Title: strong similarity to estradiol 17beta-dehydrogenase E2DH - Homo sapiens
An02g10690	Title: weak similarity to cercosporin resistance protein crg1 - Cercospora nicotianae
An02g10700	Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.; Function: CYP52A3-A of C. maltosa catalyses the terminal hydroxylation of n-alkanes.; Induction: CYP52A3-A of C. maltosa is induced by alkanes.; Pathway: CYP52A3-A of C. maltosa catalyses the first step of n-alkane assimilation.; Title: strong similarity to alkane-hydroxylating cytochrome P-450 CYP52A3-A - Candida maltosa; See PMID 1368716; See PMID 2735924
An02g10710	Function: severin kinase of D. discoideum is involved in signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Function: severin kinase of D. discoideum phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein, enabling rapid rearrangement of the actin cytoskeleton.; Similarity: belongs to the Ste20p- or p21-activated protein kinase family.; Title: strong similarity to severin kinase -Dictyostelium discoideum; cytoplasm; See PMID 9582328
An02g10730	Title: similarity to hypothetical protein CAD21413.1 - Neurospora crassa
An02g10740	Function: TIM22 of N. crassa is essential for mitochondrial import of AAC-class carrier proteins.; Function: TIM22 of N. crassa is involved in targeting of nuclear-encoded preproteins with internal targeting signals to the mitochondrial inner membrane.; Title: strong similarity to mitochondrial inner membrane translocase component TIM22 - Neurospora crassa; localisation:mitochondrion; See PMID 9368075; See PMID 11405338
An02g10750	Catalytic activity: O3-acetyl-L-serine + H2S = L-cysteine + acetate; Function: the catalytic activity of cysB of A. nidulans requires pyridoxal-phosphate as a cofactor.; Remark: cysB of A. nidulans is also named O-acetylserine (thiol)-lyase.; Title: strong similarity to cysteine synthase cysB -Aspergillus nidulans; See PMID 9108143
An02g10760	Function: the condensin complex of S. pombe is essential for mitotic chromosome condensation.; Localization: condensin of S. pombe translocates from the cytoplasm to the nucleus during mitosis due to phosphorylation by Cdc2.; Similarity: also shows strong similarity to the condensin complex component cnd3 of Schizosaccharomyces pombe (see PMID reference).; Title: strong similarity to essential protein AN97 from patent WO9924580-A2 - Aspergillus nidulans; See PMID 10485849
An02g10770	Title: questionable ORF
An02g10780	Function: Ran-binding proteins regulate the interaction between Ran-GTPase and the nucleoporin complex.; Pathway: the interaction of Ran-GTPase with the nucleoporin complex controls the nuclear export pathway.; Similarity: contains a putative zinc finger domain of the Ran-binding protein family.; Title: strong similarity to hypothetical RNA-binding zinc finger protein CAB11213.1 - Schizosaccharomyces pombe
An02g10790	Complex: the eukaryotic proteasome core forms a highly ordered ring-like complex consisiting of 28 distinct subunits. the S. cerevisiae homolog Pre6p is the alpha-4 subunit of the 20S proteasome core.; Function: eukaryotic proteasome complexes are involved in non-lysosomal degradation of misformed and/or short-lived proteins.; Localization: the proteasome of S. cerevisiae has been shown to be localized mainly at the nuclear envelope-endoplasmic reticulum network.; Title: strong similarity to proteasome 20S subunit Pre6 - Saccharomyces cerevisiae; See PMID 7918444; See PMID 9799224
An02g10800	Title: strong similarity to hypothetical zinc-finger protein SPBC3B9.05 - Schizosaccharomyces pombe
An02g10810	Similarity: the C-terminus shows homology to synaptojanin-like IPP phosphatases which are involved in the control of vesicle recycling (see PMID reference).; Title: strong similarity to hypothetical polyphosphoinositide phosphatase B18D24.60 - Neurospora crassa; See PMID 10931870
An02g10830	Function: ATR1 of S. cerevisiae confers resistance to aminotriazole and 4-nitroquinoline-N-oxide.; Remark: the systematic gene name of ATR1 of S. cerevisiae is YML116w.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2123132; See PMID 3280970
An02g10840	Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: a putative sequencing error results in an frameshift.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta [putative frameshift]; endoplasmatic reticulum; putative frameshift; See PMID 7764227; See PMID 8882724; See PMID 9349702
An02g10850	Remark: possible sequencing error at position 13159 leading to a frameshift which would destroy the zinc-finger domain.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: similarity to hypothetical transcription regulator of arginine catabolism arcA - Aspergillus nidulans [putative frameshift]; putative frameshift
An02g10860	Title: weak similarity to hypothetical protein encoded by An19g00070 - Aspergillus niger
An02g10870	Localization: PTH11 of M. porthe is an integral plasma membrane protein.; Remark: contains five putative transmembrane domains.; Similarity: PTH11 of M. porthe is almost twice as long.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An02g10890	Catalytic activity: catalyzes prenylation of para-hydroxybenzoate.; Pathway: second step in coenzyme Q biosynthesis pathway; Remark: disruption of the chromosomal COQ2 gene indicates the gene is not essential for viability, yet is required for PHB:polyprenyltransferase activity and respiratory function.; Title: strong similarity to para-hydroxybenzoate-polyprenyltransferase Coq2 -Saccharomyces cerevisiae; See PMID 1740455
An02g10900	Title: similarity to hypothetical protein encoded by An10g00180 - Aspergillus niger
An02g10920	Catalytic activity: RCH2NH2 + H2O = RCHO + NH3 + H2O2.; Localization: using transmission electron microscopy, the amine oxidase activity in Aspergillus niger AKU 3302 was localized to the outer side of the cell wall but not inside the cell using the cerium perhydroxide deposition method.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism; beta-alanine metabolism; alkaloid biosynthesis II.; Remark: northern blot analysis indicated that AO-I was highly expressed in A. niger grown on n-butylamine as a single nitrogen source.; Similarity: belongs to the amine oxidases (copper-containing). AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; See PMID 8620882; See PMID 10896215
An02g10930	Remark: strong similarity to Corynebacterium glutamicum HA protein sequence SEQ ID NO:386 patent WO200100842-A2.; Remark: the predicted ORF represents a probable nadh-dependent flavin oxidoreductase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:386 from patent WO200100842-A2 - Corynebacterium glutamicum
An02g10940	Function: StcS of A. nidulans is involved in the conversion of versicolorin A to demethylsterigmatocystin.; Pathway: StcS of A. nidulans is involved in the sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 8643646; See PMID 10618248; See PMID 7486998
An02g10960	Similarity: the hypothetical A. niger protein with similarity to this ORF is described with weak similarity to the integral membrane protein PTH11 of M. grisea.; Title: similarity to hypothetical protein encoded by An12g05390 - Aspergillus niger
An02g10970	Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to sequence 6 from patent WO0144446-A6 - Homo sapiens
An02g10980	Remark: similarity to A. niger ESTs an_3449, an_2275, an_3290 and an_2495.; Similarity: the ORF shows weak similarity to another A. niger protein.; Title: similarity to hypothetical glutathione S-transferase BAB68404.1 - Gibberella fujikuroi
An02g10990	Similarity: the ORF shows similarity to another A. niger protein. This other protein displays similarity to the cercosporin resistance protein Crg1 of Cercospora nicotianae.; Title: similarity to hypothetical protein encoded by An17g00650 - Aspergillus niger
An02g11000	Catalytic activity: 2 farnesyl diphosphate = pyrophosphate + presqualene diphosphate; presqualene diphosphate = pyrophosphate + cyclopropylcarbinyl cation; cyclopropylcarbinyl cation + NADPH = squalene + NADP+.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: the yeast Candida utilis does not possess an endogenous biochemical pathway for the synthesis of carotenoids. The central isoprenoid pathway concerned with the synthesis of prenyl lipids is present in C. utilis and active in the biosynthesis of ergosterol.; Remark: through metabolic engineering of the isoprenoid pathway, a sevenfold increase in the yield of lycopene has been achieved. The influential steps in the pathway that were manipulated were 3-hydroxy methylglutaryl coenzyme A (HMG-CoA) reductase, encoded by the HMG gene,and squalene synthase, encoded by the ERG9 gene.; Similarity: belongs to the; Title: strong similarity to squalene synthase ERG9 -Candida utilis; See PMID 8474436; See PMID 9647847
An02g11010	Title: weak similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger
An02g11030	Catalytic activity: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.; Pathway: propanoate metabolism.; Remark: ACC synthase from P. citrinum had 430 amino acid residues and a shorter C terminal than the plant enzyme. The enzyme purified from Escherichia coli transformed with ACC-synthase-encoding DNA showed similar properties to those of the purified enzyme from P. citrinum. S. cerevisiae with ACC synthase accumulated ACC in the medium with increasing time of incubation.; Similarity: belongs to the 1-aminocyclopropane-1-carboxylate synthases.; Title: strong similarity to ACC synthase acs -Penicillium citrinum; See PMID 11515533
An02g11040	Catalytic activity: citrate = isocitrate.; Pathway: citrate cycle (TCA cycle); glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) forms. the active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Remark: an iron-sulfur protein. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts isocitrate into cis-aconitate.; Similarity: belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545
An02g11050	Remark: disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transport protein Stl1 - Saccharomyces cerevisiae; See PMID 8076821
An02g11060	Remark: strong similarity to Neisseria meningitidis sequence 43 patent FR2785293-A/43 and patent WO200026375-A2.; Title: strong similarity to sequence 43 from patent FR2785293-A - Neisseria meningitidis
An02g11070	Function: the yeast gene is a positive regulator of URA1 and URA3 expression.; Remark: PPR1 is a yeast transcription factor that contains a six-cysteine, two-zinc (Zn) domain, homologous to a similar structure in GAL4. Like GAL4, it binds to DNA sites with conserved CGG triplets symmetrically placed near each end. Whereas the GAL4 site has 11 intervening base pairs, the PPR1 site has 6.; Remark: the S. cerevisiae gene PPR1 encodes a positive regulator of the expression of the two unlinked structural genes URA1 and URA3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 7958913; See PMID 11297736; See PMID 6096561; See PMID 6096562
An02g11080	Catalytic activity: catalyzes the conversion of 2-pyrone-4,6-dicarboxylate + H2O to oxalomesaconate.; Pathway: involved in the phthalate catabolic pathway.; Title: similarity to 2-pyrone-4,6-dicarboxylate hydrolase pcmC - Arthrobacter keyseri; See PMID 11371533
An02g11090	Localization: Yhm2p S. cerevisiae is localized in the mitochondrial inner membrane and is also associated with mitochondrial DNA in vivo.; Remark: Yhm2p S. cerevisiae exhibits general DNA-binding activity in vitro. Yhm2p may function as a member of the protein machinery for the mitochondrial inner membrane attachment site of mitochondrial DNA during replication and segregation of mitochondrial genomes.; Remark: alternative name is YMR241w.; Title: strong similarity to suppressor gene of mitochondrial histone Yhm2 - Saccharomyces cerevisiae; See PMID 9742088
An02g11110	Title: questionable ORF
An02g11120	Remark: C-terminal truncated ORF due to end of contig.; Remark: strong similarity to Arabidopsis thaliana OPT family member emb CAB10414. 1 patent WO200052162-A2.; Remark: the ORF represents a putative mammalian enkephalin transport proteins for transporting enkephalin across cell membrane.; Title: strong similarity to oligopeptide transporter family member emb CAB10414.1 from patent WO200052162-A2 -Arabidopsis thaliana [truncated ORF]
An02g11130	Function: isp4 of S. pombe was originally identified by subctractive screening as gene induced during the sexual differentiation process.; Function: subsequently, it was demonstrated that isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: N-terminal truncated ORF due to end of contig.; Similarity: the predicted A. niger protein shows strong similarity to isp4 of S. pombe, which belongs to a group of transporters specific for small oligopeptides,which is called the OPT family (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe [truncated ORF]; plasma membrane; See PMID 9643541; See PMID 7954893
An02g11140	Catalytic activity: PT1 of P. taeda catalyzes the reduction of the benzylic ether bond of dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alchool to produce,respectively, isodihydrodehydrodiconyferyl alcohol and tetrahydrodehydrodiconiferyl alcohol.; Function: these compounds, as many other phenylpropanoids, are crucial for plant defense mechanisms,especially against fungal infections.; Title: similarity to phenylcoumaran benzylic ether reductase PT1 - Pinus taeda; See PMID 10066819
An02g11150	Catalytic activity: alpha-galactosidase from A. niger catalyses the reaction melibiose + H(2)O = galactose + glucose.; Function: alpha-galactosidase participates in the hydrolysis of complex plant saccharides such as galacto(gluco)mannans.; Gene-ID: aglB; Remark: in A. niger, there are three known genes encoding alpha-galactosidase, aglA, aglB and aglC.; extracellular/secretion proteins; See PMID 10347026
An02g11160	Similarity: the ORF shows strong similarity to the A. niger EST an_3218.; Title: strong similarity to hypothetical protein CAD70913.1 - Neurospora crassa
An02g11170	Similarity: the predicted A. niger protein shows similarity to hypothetical proteins of several procaryotic species.; Title: similarity to hypothetical protein PA2706 -Pseudomonas aeruginosa
An02g11180	Title: strong similarity to EST an_0208 -Aspergillus niger
An02g11190	Similarity: the predicted A. niger protein shows strong similarity to protein fragment SEQ ID NO: 75556 of patent EP1033405-A2 (Acc. # AAG58521) from Z. mays and many conserved hypothetical proteins from procaryotic and eucaryotic organisms.; Title: strong similarity to protein fragment SEQ ID NO:75556 from patent EP1033405-A2 - Zea mays
An02g11200	Title: similarity to 13 kD subunit of NADH:ubiquionen reductase - Bos taurus; localisation:mitochondrion; putative frameshift
An02g11210	Title: weak similarity to hypothetical protein CG4548 - Drosophila melanogaster
An02g11230	Title: strong similarity to hypothetical protein YDR196c - Saccharomyces cerevisiae
An02g11260	Function: monosaccharide transporter Mst-1 of A. muscaria is involved in the active uptake of monosaccharides.; Induction: monosaccharide transporter Mst-1 of A. muscaria is upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Similarity: the predicted A. niger protein shows strong similarity to the monosaccharide transporter Mst-1 of A. muscaria, which belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An02g11270	Title: strong similarity to hypothetical protein EAA63528.1 - Aspergillus nidulans
An02g11280	Title: weak similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans
An02g11290	Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate + H(2) <=> D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; Function: Plc1 from S. pombe is a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase.; Function: activated by all classes of cell surface receptors, Plc proteins generate the ubiquitous second messengers inositol 1,4,5-trisphosphate and diacylglycerol.; Phenotype: the mutant plc1-1 of S. pombe is unable to grow on a minimal medium containing high amounts of phosphate.; Title: similarity to phosphoinositide-specific phospholipase C lc1p - Schizosaccharomyces pombe; See PMID 11015615; See PMID 7732727; See PMID 8590474
An02g11300	Remark: Yml37 from S. cerevisiae is a mitochondrial ribosomal protein of the large subunit.; Remark: synonyms for Yml37 from S. cerevisiae are Mrpl37 and YBR268w.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml37 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978
An02g11310	Title: questionable ORF
An02g11320	Remark: about the patent is no further information available.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Similarity: the ORF encoded protein shows also strong similarities to epimerases.; Title: strong similarity to protein fragment SEQ ID NO:15392 from patent EP1033405-A2 - Arabidopsis thaliana
An02g11330	Induction: the mRNA for spherulin 4 of P. polycephalum protein accumulates during spherulation.; Remark: spherulin 4 of P. polycephalum has many features of a plasma membrane protein: a signal peptide and a long hydrophobic region, which could serve as a transmembrane anchor.; Title: similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775
An02g11340	Title: weak similarity to hypothetical protein encoded by B13I18.180 - Neurospora crassa
An02g11350	Title: questionable ORF
An02g11360	Similarity: the similarities to lower scored matches are mainly based on repetetive structures.; Title: strong similarity to hypothetical endo alpha-1,4 polygalactosaminidase precusor - Pseudomonas sp.
An02g11380	Remark: ORF contains 5 frameshifts, due to putative sequencing errors.; Remark: Tan1 is identical to transposon Tndm2 from Aspergillus niger.; Remark: the Tan1 element has a unique organization: IR-ORF-IR-IR-Vader-IR.; Remark: the transposase Tan1 is present as a single copy in A. niger var. awamori.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 9003286
An02g11390	Similarity: the ORF also shows strong similarity to the EST an_2371 from Aspergillus niger.; Similarity: the similarities of lower scored matches are based on repetetive structures.; Title: strong similarity to hypothetical protein encoded by DR0708 - Deinococcus radiodurans
An02g11400	Title: strong similarity to hypothetical protein CAD70539.1 - Neurospora crassa [truncated ORF]
An02g11410	Remark: the A. niger ORF is N-terminally truncated due to the contig border.; Remark: the A. niger ORF shows strong similarity to EST an_3206 of A. niger.; Similarity: the ORF shows also weak similarity to the hypothetical protein PA3059 of P. aeruginosa.; Similarity: the ORF shows strong similarity to another A. niger protein. This other protein displays weak similarity to the UDP-glucose-polyglycerol phosphate glucosyltransferase tagE of B. subtilis.; Title: strong similarity to hypothetical protein encoded by An12g10440 - Aspergillus niger [truncated ORF]
An02g11420	Gene-ID: dapB; Remark: the A. niger protein is unpublished.
An02g11430	Remark: blastp matches are unspecific.
An02g11440	Title: strong similarity to hypothetical protein SPCC1450.12 - Schizosaccharomyces pombe
An02g11460	Pathway: N. crassa homolog met-10+ is putatively involved in methionine pathway.; Title: strong similarity to hypothetical protein met-10+ - Neurospora crassa
An02g11470	Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Localization: GFP-Rpb4 fusion protein was detected in the cytoplasm as well as the nuclei.; Remark: S. cerevisiae homolog RPB4 is essential for yeast cell growth and normal levels of RNA polymerase II activity, but not absolutely essential for mRNA synthesis.; Title: strong similarity to 16 kD subunit DNA-directed RNA polymerase II rpb4p - Schizosaccharomyces pombe; nucleus; See PMID 11168400
An02g11480	Function: the Aspergillus nidulans homolog TamA functions as a co-activator of AreA, the major nitrogen regulatory protein in A. nidulans.; Localization: a GFP fusion with A. nidulans TamA is predominantly localized in the nucleus.; Remark: presence or absence of ammonium does not affect nuclear localization of GFP-TamA in A. nidulans.; Remark: the predicted DNA-binding domain of A. nidulans TamA is not essential for function.; Title: strong similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; nucleus
An02g11490	Title: strong similarity to EST an_0572 -Aspergillus niger
An02g11500	Remark: S. cerevisiae homolog YIL130w contains GAL4 zinc binuclear cluster domain.; Similarity: the ORF shows also similarity to probable membrane protein YIL130w of S. cerevisiae. However, the length of the ORF is only one third of the S. cerevisiae protein.; Title: weak similarity to zinc binuclear cluster protein sequence #124 from patent WO200224865-A2 -Unclassified organism
An02g11510	Remark: Drosophila melanogaster RpII215 encodes the largest subunit of RNA polymerase II with a molecular weight of 215 kDa.; Title: weak similarity to largest subunit of RNA polymerase II RpII215 - Drosophila melanogaster
An02g11530	Remark: strong similarity to HA protein sequence SEQ ID NO:416 patent WO200100842-A2 from Corynebacterium glutamicum.; Remark: the predicted ORF is a putative hydroxyquinol-1, 2-dioxygenase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:416 from patent WO200100842-A2 - Corynebacterium glutamicum
An02g11550	Remark: E. coli homolog b1423/YDCJ is a hypothetical protein in TRG-RIML intergenic region.; Title: strong similarity to hypothetical protein ydcJ - Escherichia coli
An02g11560	Function: A. parasiticus homolog versicolorin B synthase (vsb) catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Pathway: Aspergillus parasiticus aflatoxin biosynthetic pathway.; Remark: A. parasiticus vsb possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes. However, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689
An02g11570	Remark: S. c. homolog is a mitochondrial ribosomal protein.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml49 - Saccharomyces cerevisiae; localisation:mitochondrion
An02g11580	Remark: strong similarity to Human secreted protein sequence encoded by gene 48 SEQ ID NO:188 patent WO200056754-A1.; Title: strong similarity to secreted protein sequence encoded by gene 48 SEQ ID NO:188 from patent WO200056754-A1 - Homo sapiens [putative pseudogene]; putative pseudogene
An02g11590	Function: Rps1 is required for sporulation.; Function: S. cerevisiae Rps1/Mps1 is required for spindle pole body duplication and has a mitotic checkpoint function.; Remark: alternative gene name for S. cerevisiae RPS1 is MPS1; Remark: phosphoamino acid analysis of substrates phosphorylated by Mps1p indicates that this kinase can phosphorylate serine, threonine and tyrosine residues,identifying Mps1p as a dual specificity protein kinase.; Title: strong similarity to serine/threonine protein kinase Rpk1 - Saccharomyces cerevisiae
An02g11600	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 154 amino acids long.
An02g11610	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 154 amino acids long.
An02g11625	Remark: similarities are based on glycin/serin rich structures.; Title: weak similarity to RNA helicase GLH-2 -Caenorhabditis elegans
An02g11630	Remark: the ORF contains a PWI motif, which is often present in splicing factors suggesting it might be important for multiple interactions within splicing complexes.; Title: strong similarity to hypothetical Ser/Arg-related nuclear matrix protein - Mus musculus
An02g11640	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 111 amino acids.; Title: questionable ORF
An02g11650	Remark: the first intron is unusually long.
An02g11660	Similarity: the ORF shows strong similarity to several putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerases from bacteria.; Title: strong similarity to hypothetical homolog of prokaryotic 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase SPBC21C3.09c - Schizosaccharomyces pombe
An02g11680	Function: eIF-4A of S. pombe recognizes and binds to the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures.; Remark: eIF-4A of S. pombe is also called mRNA CAP-binding protein, eIF-4F 25 kDA subunit, TIF451, TIF45,TIF1 or SPAC16E8. 15.; Title: strong similarity to translation initiation factor eIF-4A - Schizosaccharomyces pombe
An02g11690	Title: strong similarity to hypothetical protein F3F9.18 - Arabidopsis thaliana
An02g11700	Phenotype: CTR2 overexpression in S. pombe provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity.; Phenotype: S. pombe ctr2 mutants display a high level of resistance to toxic copper concentrations.; Similarity: the ORF overlaps with A. niger ESTs an_0415 (EMBLEST:BE760746), an_3561 (EMBLEST:BE759211) and entry PATENTDNA:AAF11529 SEQ ID NO:4052.; Title: strong similarity to copper transport protein Ctr2 - Saccharomyces cerevisiae; See PMID 7499355
An02g11710	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 113 amino acids long.
An02g11720	Function: alpha-mannosidases facilitate the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, which originate from N-linked carbohydrate chains released during glycoprotein turnover.; Title: strong similarity to alpha-mannosidase msd2 -Aspergillus nidulans
An02g11730	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 137 amino acids long.; Title: questionable ORF
An02g11740	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 65 amino acids l; Title: questionable ORF
An02g11750	Similarity: the ORF overlaps with A. niger ESTs an_2297 (EMBLEST:BE759480), an_2292 (EMBLEST:BE759475) and an_2887 (EMBLEST:BE759941).; Title: strong similarity to hypothetical conserved protein SPBC337.10c - Schizosaccharomyces pombe
An02g11760	Remark: the A. niger EST is decribed in PATENTDNA:AAF11691 EST SEQ ID NO:4214.; Title: strong similarity to EST SEQ ID NO:4214 from patent WO200056762-A2 - Aspergillus niger
An02g11770	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 88 amino acids long.; Title: questionable ORF
An02g11780	Remark: the intron-exon structure of the ORF is not typical for A. niger proteins.
An02g11790	Function: pcd1 of S. cerevisiae is a putative peroxisomal nudix hydrolase active towards coenzyme A and its derivatives.; Remark: in constrast to pcd1 of S. cerevisiae, no membrane region was predicted in the ORF.; Title: similarity to hypothetical coenzyme A diphosphatase Pcd1 - Saccharomyces cerevisiae
An02g11800	Function: YPR125w of S. cerevisiae supresses the splicing defect caused by the disruption of the nuclear MRS2 gene (mrs2-1 mutation), which causes a strong pet-phenotype in strains with mitochondrial group II introns, and a leaky pet-phenotype in strains without group II introns.; Title: strong similarity to hypothetical membrane protein YPR125w - Saccharomyces cerevisiae
An02g11810	Title: strong similarity to hypothetical conserved protein 12F11.50 - Neurospora crassa
An02g11820	Catalytic activity: phaB of A. latus converts (R)-3-hydroxyacyl-CoA + NADP(+) <=> 3-oxoacyl-CoA + NADPH.; Function: phaB of A. latus is involved in the metabolism of butanoate.; Remark: a puative frameshift due to a possible sequencing error at position 609 (one base too much) was corrected.; Title: strong similarity to acetoacetyl-CoA reductase phaB - Alcaligenes latus [putative frameshift]; putative frameshift
An02g11830	Catalytic activity: glutathione S-transferases convert RX + glutathione <=> HX + R-S-glutathione.; Function: URE2 of S. cerevisiae is involved in cellular responses to the nitrogen source.; Phenotype: disruption of URE2 in S. cerevisiae showed that URE2 is regulating GLN1 and GDH2, the structural genes for glutamine synthetase and NAD-linked glutamate dehydrogenase, respectively, at the transcriptional level.; Title: strong similarity to glutathione transferase homolog Ure2 - Saccharomyces cerevisiae
An02g11850	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 94 amino acids long.; Title: questionable ORF
An02g11860	Title: strong similarity to hypothetical Ydr124wp-like protein - Pneumocystis carinii
An02g11870	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 104 amino acids long.; Title: questionable ORF
An02g11880	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins.; Title: questionable ORF
An02g11890	Similarity: the ORF shows also weak similarity to heparanase Hep of R. norvegicus and of H. sapiens.; Title: strong similarity to hypothetical protein encoded by An14g01330 - Aspergillus niger
An02g11900	Function: SMC1 of S. cerevisiae is a coiled-coil protein involved in chromosome structure or segregation,which is essential for yeast nuclear division.; Phenotype: smc1p-depleted S. cerevisiae cells have a defect in nuclear division as evidenced by the absence of anaphase cells.; Phenotype: the smc1-1 mutant of S. cerevisiae was identified initially as a mutant of S. cerevisiae that had an elevated rate of minichromosome nondisjunction.; Remark: SMC1 of S. cerevisiae is also called chl10 or YFL008W.; Remark: a putative sequencing error in the fourth exon results in an frameshift.; Title: strong similarity to chromosome segregation protein Smc1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 7929577; See PMID 8442383
An02g11910	Function: pdx1 of S. cerevisiae plays a structural role in the PDH complex, i. e., it binds and positions E3 (dihydrolipoamide dehydrogenase) to the E2 (dihydrolipoamide transactylase) core, and this specific binding is essential for a functional PDH complex.; Phenotype: mitochondrial extracts of S. cerevisiae pdx1 minus mutants do not catalyze a CoA- and NAD(+)-linked oxidation of pyruvate.; Remark: pdx1 of S. cerevisiae is also called dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, E3-binding protein or E3BP.; Title: similarity to mitochondrial pyruvate dehydrogenase complex protein Pdx1 - Saccharomyces cerevisiae
An02g11920	Function: Fzr1 of M. musculus is a recently identified 7WD domain member of a family, which is implicated in cell cycle regulation of Drosophila and yeast.; Function: overexpression of Fzr1 of M. musculus increases natural killer cell-mediated cell death and suppresses tumor growth.; Remark: Fzr1 of M. musculus is also called Fyr or fzr.; Remark: mammalian fizzy-related genes regulate the cyclosome. Ubiquitin-mediated proteolysis by the cyclosome plays an essential role in cell cycle control.; Similarity: the ORF shows strong similarity to the A. niger EST an_2748.; Title: strong similarity to fizzy-related protein Fzr1 - Mus musculus; See PMID 10606752; See PMID 10891459
An02g11940	Title: strong similarity to aminopeptidase METPRO02 from patent EP939131-A2 - Homo sapiens
An02g11950	Title: similarity to hypothetical protein SPAC4D7.11 - Schizosaccharomyces pombe
An02g11960	Complex: E. coli clpP is the proteolytic component of clp proteinase. The Clp holoenzyme consists of two adjacent heptameric rings of the proteolytic subunit ClpP,which are flanked by a hexameric ring of a regulatory subunit from the Clp/Hsp100 chaperone family at one or both ends.; Function: the E. coli homolog clpP encodes a protease required for ATP-driven cleavage of proteins to small peptides; Remark: electron micrographs of the protein show superimposed disk-like structures with a central cavity,similar in appearance to purified proteasomes from eukaryotic cells.; Remark: the proposed function of the ClpX/ClpP complex in eukaryotic mitochondria is to exhert functions similar to the proteasome in this subcellular compartment.; Title: strong similarity to endopeptidase Clp chain P clpP - Escherichia coli
An02g11970	Function: pho13 of S. pombe and aryl phosphatases functions as a phosphoric monoester hydrolase.; Remark: pho13 of S. pombe is also called PHO13 or SPBC15D4. 15.; Similarity: the predicted ORF shows similarity to nitrophenylphosphatases and acryl phosphatases from different species.; Title: strong similarity to 4-nitrophenylphosphatase pho13p - Schizosaccharomyces pombe; cytoplasm
An02g11980	Function: rfc is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA.; Function: rfc2 of S. cerevisiae interacts with the CDC44/RFC1 and RFC5 gene products in the RF-C complex and with both DNA polymerases during chromosomal DNA replication.; Phenotype: disruption of the rcf2 gene in S. cerevisiae led to a dumbbell-shaped terminal morphology,common to mutants having a defect in chromosomal DNA replication.; Phenotype: mutant rcf2 in S. cerevisiae courses temperature-sensitive cell growth, defects in the integrity of chromosomal DNA at restrictive temperatures,progression through cell cycle without definitive terminal morphology and rapid loss of cell viability at restrictive temperatures, sensitivity to hydroxyurea, methyl methanesulfonate and UV light and an increased rate of spontaneous mitotic recombination and chromosome loss.; Remark: replication factor C is also called activator 1.; Title: strong similarity to replication factor C chain Rfc2 - Saccharomyces cerevisiae; nucleus; See PMID 9671499
An02g11990	Function: sec20 of C. albicans is probably involved in vesicle formation for retrograde golgi-ER protein transport.; Phenotype: reduced sec20 expression in the C. albicans PCK1p-SEC20 strain is not affecting morphogenesis but leads to a series of hypersensitivity phenotypes including supersensitivity to aminoglycoside antibiotics,to nystatin, to sodium dodecyl sulfate, and to cell wall inhibitors.; Phenotype: repression of sec20 expression in C. albicans prevented (MET3p-SEC20 allele) or retarded (PCK1p-SEC20 allele) growth and led to the appearance of extensive intracellular membranes, which frequently formed stacks.; Remark: the predicted ORF contains an C-terminal ER retention signal (KDEL), which is homologues to the yeast retention signal HDEL found in sec20 of S. cerevisae and unusual for a membrane protein.; Similarity: the similarity of the predicted ORF to sec20 of C. albicans is restricted to the inner part of the ORF, reaching from amino acid 50 to 280.; Title: similarity to protein involved in protein secretion sec20 - Candida albicans; See PMID 1537327; See PMID 11114899
An02g12000	Remark: the predicted intron-exon structure of the ORF and its lenght are suboptimal.; Similarity: the predicted ORF shows weak similarity to a short stretch (73 bp) of the A. nidulans ESTEMBLEST:AI213526.; Title: similarity to ribosomal protein YmL44-like protein CAE76322.1 - Neurospora crassa
An02g12010	Catalytic activity: ipp1 of S. cerevisiae converts pyrophosphat + H(2)O = 2 orthophosphate.; Function: ipp1 of S. cerevisiae catalyzes the hydrolysis of pyrophosphate to orthophosphate.; Induction: for the activation of ipp1 from S. cerevisiae the presence of a divalent metal cation is necessary, magnesium confers the highest activity.; Remark: inorganic pyrophosphatases can be active in cytosol or mitochiondrium.; Remark: ipp1 of S. cerevisiae is also called PPA1,PPA, YBR011C, YBR011 or YBR0202.; Similarity: the predicted ORF shows similarity to several inorganic pyrophosphatases from different species.; Title: strong similarity to inorganic pyrophosphatase Ipp1 - Saccharomyces cerevisiae
An02g12030	Function: smm1 of S. cerevisiae is involved in the synthesis and processing of mitochondrial tRNAs.; Phenotype: overexpression of smm1 in S . cerevisiae weakly suppresses a mutation affecting the maturation of mitochondrial tRNA-Asp.; Phenotype: the smm1 mutation in S. cerevisiae cells confers temperature-sensitiv growth and aberrant mitochondrial inheritance and morphology at the nonpermissive temperature.; Remark: smm1 of S. cerevisiae is also called YNR015W or N2065.; Similarity: the similarity to smm1 of S. cerevisiae is restricted to its N-terminal part, reaching to amino acid 300.; Title: strong similarity to hypothetical tRNA--dihydrouridine synthase Smm1 - Saccharomyces cerevisiae; See PMID 9211792; See PMID 10366593
An02g12040	Phenotype: disruption of the fun30 gene in S. cerevisiae surprisingly resulted in increased resistance to UV irradiation.; Remark: synonyms for fun30 of S. cerevisiae are YAL019W or YAL001.; Similarity: the predicted ORF shows strong similarity to several helicases from different species.; Title: strong similarity to helicase Fun30 -Saccharomyces cerevisiae; nucleus; See PMID 10454593; See PMID 8144453
An02g12050	Function: Vma21p of S. cerevisiae is involved in vacuolar H-ATPase assembly or function, which is important for vacuolar acidification.; Phenotype: null mutants of vma21 cannot grow on glycerol or at pH 7. 5 and exhibits increased calcium sensitivity.; Remark: the systematic name for VMA21 is YGR105W.; Title: similarity to V-ATPase assembly protein Vma21 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10600674; See PMID 7841520; See PMID 8416931
An02g12060	Catalytic activity: cystathione beta-synthases convert L-serine + L-homocysteine <=> cystathionine + H(2)O.; Function: cystathione beta-synthases have sulfhydrase and beta-thionase activity and catalyzs the first irreversible step in homocysteine transulfuration.; Induction: cystathione beta-synthase are pyridoxal-phosphate dependent.; Similarity: the ORF shows similarity to the C-terminal end of cysB from D. discoideum including the characteristic CBS domain.; Title: similarity to hypothetical cystathione beta-synthase cysB - Dictyostelium discoideum
An02g12070	Repression: the activity of phosphate transporters can be inhibited by N-ethylmaleimide.; Similarity: the predicted ORF shows strong similarity to several mitochondrial phosphate transporters; Title: strong similarity to mitochondrial phosphate transport protein G7 - Glycine max; localisation:mitochondrion; See PMID 10437831
An02g12080	Similarity: the ORF shows similarity to several glycine-rich proteins.; Similarity: the predicted ORF overlaps with A. niger EST EMBLEST:BE759579.
An02g12090	Similarity: the predicted ORF shows similarity to several glutamic acid-rich proteins due to its high glutamic acid content.; Similarity: the similarity to the other A. niger protein, however, is short (about 60 amino acids) but highly specific.; Title: weak similarity to hypothetical protein encoded by An03g06210 - Aspergillus niger
An02g12100	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g12120	Remark: rpl37B of S. cerevisiae is also called YOR234C, RPL35B, YDR500C or D9719. 6.; Remark: there are two genes for rpl37 in S. cerevisiae rpl37A and rp37B with only one conservative amino acid difference.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759376, EMBLEST:BE759740 and PATENTDNA:AAF11451 EST SEQ ID NO:3974.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Rpl37b - Saccharomyces cerevisiae; cytoplasm; See PMID 8082197
An02g12130	Remark: the sequence overlaps with A. niger EST EMBL:ANNGSDA (A. niger gsdA gene).; Title: questionable ORF
An02g12140	Catalytic activity: gsdA of A. niger converts glucose-6-phosphate + NADP(+) = D-glucono-delta-lactone 6-phosphate + NADPH.; Function: gsdA of A. niger catalyses the first step in the pentose phosphate pathway.; Gene-ID: gsdA; Phenotype: overexpression of gsdA in A. niger was shown to be deleterious for the fungus, especially when cotransformants were grown on media containing ammonia.; Remark: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE760650, EMBL:ANG6PDHSE (A. niger mRNA for glucose-6-phosphate dehydrogenase) and EMBL:ANNGSDA (A. niger gsdA gene).; Repression: glucose-6-phosphat 1-dehydrogenase is inhibited by NADPH and stimulated by NADP(+).; cytoplasm
An02g12150	Similarity: the sequence probably contains a putative duplication fragment of the 3' ORF, as it overlaps with a part of the A. niger gsdA gene sequence (EMBL:ANNGSDA).; Title: questionable ORF
An02g12160	Function: suc1 of P. major catalyzes the active uptake of sucrose or maltose and is sensitive to uncouplers.; Similarity: the ORF shows similarity to several sucrose transporters from different species.; Title: strong similarity to sucrose transport protein suc1 - Plantago major
An02g12170	Function: msb1 of S. cerevisiae is involved in the establishment of cell polarity and bud formation.; Remark: msb1 of S. cerevisiae is also called YOR188W.; Similarity: the ORF shows similarity to some nucleolus-cytoplasm shuttle phosphoproteins.; Similarity: the similarity of the predicted ORF to msb1 from S. crevisiae is restricted to its N-terminal end,ending with amino acid 350.; Title: strong similarity to morphogenesis-related protein Msb1 - Saccharomyces cerevisiae; See PMID 2690082
An02g12190	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g12210	Function: mef2a of H. sapiens is a transcription factor involved in cell proliferation and differentiation,which binds to conserved A/T-rich sequence in the control regions of numerous muscle-specific genes.; Remark: mef2a is also called mf2A.; Similarity: due to its high proline content, the predicted ORF shows similarity to several hydroxyproline-rich proteins.; Similarity: the similarity of the predicted ORF to mef2A from H. sapiens is locally high in its N-terminal part, reaching from amino acid 1 to 430 and including all characteristic motivs of the transcription factor.; Title: strong similarity to myocyte-specific enhancer factor mef2A - Homo sapiens; nucleus; See PMID 8114702; See PMID 8148875
An02g12220	Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Remark: the poly-A end of the predicted ORF overlaps with A. niger ESTs EMBLEST:BE760322 and EMBLEST:BE760339.; Similarity: the ORF shows strong similarity to several multi drug resistance transporters with different specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe
An02g12230	Similarity: the ORF is similar to the region of homologues protein, where the calcium-binding domain (EF-hand) is located.; Similarity: the predicted ORF shows similarity to several calcium-binding proteins with different functions,like calpain-related proteins.; Title: strong similarity to calcium-binding protein abp32 - Homo sapiens
An02g12240	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 99 amino acids.; Title: questionable ORF
An02g12250	Function: the short-chain dehydrogenase family is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases.; Similarity: the predicted ORF shows similarity to several proteins, which are members of the short-chain dehydrogenase/reductase superfamily (SDR).; Title: strong similarity to alcohol dehydrogenase pan2 - Mus musculus
An02g12260	Remark: the predicted intron-exon structure of the ORF is unusual.; Similarity: the similarity of the ORF to the hypothetical protein SPBC31F10. 03 of S. pombe is restricted to the inner part of the molecules, reaching from amino acids 24 to 200.; Title: strong similarity to hypothetical protein SPBC31F10.03 - Schizosaccharomyces pombe
An02g12270	Induction: the transcript of grrbp2 of E. esula is induced in response to low temperatures.; Similarity: the ORF shows similarity to several RNA-binding proteins with glycine-rich domains.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759828 and PATENTDNA:AAF11490 SEQ ID NO:4013.; Title: strong similarity to glycine-rich RNA-binding protein grrbp2 - Euphorbia esula; See PMID 9747799; See PMID 10858526
An02g12290	Function: sf1 contributes to the recognition of the 3' splice site by interacting with U2AF65 and binding to the intron branch site during the formation of the early splicing complex.; Remark: sf1 of D. melanogatser is also called CG5836.; Similarity: the ORF is similar to sf1 of D. melanogaster in a region containing the KH-motiv and the zinc-finger motiv, which are both involved in facilitating nucleic acid binding.; Similarity: the predicted ORF is similar to the sf1 protein of D. melanogaster in inter region, including amino acids 130 to 260, but shows no homology to the N-terminal region of sf1 (RS domain found in several splicing proteins), which is believed to mediate protein-protein or protein-RNA interactions.; Title: similarity to splicing factor sf1 -Drosophila melanogaster
An02g12300	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g12310	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An02g12320	Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.; Function: the beta subunit of eIF-2 is necessary for the exchange of GDP with GTP, to enable a new round of translation initiation by eIF-2.; Remark: sui3 of S. cerevisiae is also called TIF212,WP1054 or YPL237w.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759615 and EMBLEST:BE758850.; Title: strong similarity to translation initiation factor eIF-2 beta chain Sui3 - Saccharomyces cerevisiae; cytoplasm; See PMID 2678106; See PMID 3136928
An02g12330	Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted ORF is 140 amino acids longer at its N-terminus than the homologues hypothetical proteins of the MTH747 superfamily.; Similarity: the predicted ORF shows similarity to some proteins, which are members of the superfamily catagorized by the conserved hypothetical protein MTH747.; Title: strong similarity to hypothetical conserved protein TM0367 - Thermotoga maritima
An02g12340	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g12350	Function: the ankyrin repeat is one of the most common protein sequence motifs found in a variety proteins with different activities.; Similarity: the predicted ORF shows similarity to ankyrin isoforms from several species, which is due to the presence of ankyrin-repeat homology domain.; Similarity: the similarity to ankryrin repeat domains is located in the C-terminal part of the predicted ORF, starting around amino acid 900.; Title: similarity to neuronal long splice form of ankyrin ANK2 - Homo sapiens; See PMID 1830053; See PMID 1833308; See PMID 8253844
An02g12360	Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:AN728, EMBLEST:BE758829 and EMBLEST:BE759606.; Similarity: the predicted ORF shows similarities to SH3 domain sequences of several hypothetical proteins.; Title: strong similarity to hypothetical protein csh3p - Schizosaccharomyces pombe
An02g12380	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An02g12390	Function: yeast MBF1 mediates GCN4-dependent transcriptional activation by bridging the DNA-binding region of GCN4 and TBP.; Remark: The matching A. niger EST Asc0397 matches the complementary strand, but it is likely that this EST was cloned in the wrong orientation since the splice site is matching exactely this gene model and a poly(A)-tail can be recognized at the 5-end of the EST.; Similarity: yeast MBF1 shows similarity to the bridging molecule that connects the Drosophila nuclear receptor FTZ-F1 and TATA-binding protein (TBP).; Title: strong similarity to multiprotein bridging factor 1 Mbf1 - Saccharomyces cerevisiae; nucleus; See PMID 9710580
An02g12410	Function: TIF34 of S. cerevisiae is required for cell cycle progression and for mating and plays an essential role in initiation of protein synthesis.; Remark: a putative sequencing error results in an frameshift.; Remark: the A. niger protein also shows strong similarity to the S. pombe Sum1 protein, the overexpression of which suppresses uncontrolled mitosis 1 in the cdc2-3w.; Similarity: TIF34 of S. cerevisiae and the A. niger protein show strong similarity to human TRIP-1 protein.; Title: strong similarity to translation initiation factor eIF3 subunit Tif34 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 8972194; See PMID 9671501
An02g12420	Function: the protein product of the ADE3 gene of S. cerevisiae has been identified as the cytoplasmic trifunctional C1-tetrahydrofolate (THF) synthase, which possesses 10-formyl-THF synthetase (EC 6. 3. 4. 3), 5,10-methenyl-THF cyclohydrolase (EC 3. 5. 4. 9), and 5,10-methylene-THF dehydrogenase (EC 1. 5. 1. 5) activities.; Pathway: protein product of the ADE3 gene of S. cerevisiae necessary for the biosynthesis of purines,thymydylate, methionine, histidine, panthotenate, and formyl tRNA-MET.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to trifunctional C1-tetrahydrofolate synthase Ade3 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 8464869; See PMID 3514599
An02g12430	Catalytic activity: icdA from A. niger catalyzes the reaction: isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH; Function: the activity of the mitochondrial NADP-dependent isocitrate dehydrogenase of A. niger is inhibited by an accumulation of intracellular glycerol; Gene-ID: icdA; Remark: a splice site was detected upstream of the START codon.; localisation:mitochondrion; See PMID 8885410
An02g12440	Remark: blastp matches are due to repetitive amino acids.
An02g12450	Function: tomato XOPG1 is involved weakening of the endosperm tissue during germination.; Title: similarity to polygalacturonase XOPG1 -Lycopersicon esculentum; See PMID 10517833
An02g12460	Title: strong similarity to EST SEQ ID NO:4225 from patent WO200056762-A2 - Aspergillus niger
An02g12470	Title: weak similarity to protein kinase Elm1 -Saccharomyces cerevisiae
An02g12480	Title: weak similarity to mitochondrial transcription factor mtTFB - Kluyveromyces lactis
An02g12490	Remark: the function of the protein from EP1033405-A2 has not been described.; Title: similarity to protein fragment SEQ ID NO:24712 from patent EP1033405-A2 - Arabidopsis thaliana
An02g12500	Remark: other uses include peptide hydrolysis, waste treatment and cleavage of fusion proteins.; Remark: the B. subtilis hydrolase YQJL as well as other recombinant hydrolases from gram-positive bacteria are useful in cleaning (e. g. detergent) or textile treatment compositions, and in animal feeds.; Title: similarity to hydrolase protein YQJL from patent WO9927081-A2 - Bacillus subtilis
An02g12503	Function: a tfs1 deletion strain of S. pombe has a slow growth phenotype and increased sensitivity to the drug 6-azauracil.; Remark: tfs1 from S. pombe is not essential for viability since a haploid S. pombe strain with tfs1 deleted from the genome is viable.; Similarity: tfs1 from S. pombe shows similarities to genes of other organisms encoding transcription elongation factor TFIIS.; Title: strong similarity to transcription elongation factor TFIIS encoded by tfs1p - Schizosaccharomyces pombe; nucleus; See PMID 8904334
An02g12505	Function: the expressed protein PMEA from Aspergillus had a molecular mass of 38. 5 kDa, a pH optimum of 5. 0, and a temperature optimum of 55 degrees C.; Similarity: pmeA from Aspergillus oryzae is very similar to those of Aspergillus niger PMEA and Aspergillus aculeatus PME1.; Title: similarity to pectin methylesterase pmeA -Aspergillus oryzae; See PMID 10052131
An02g12510	Catalytic activity: H(+)[intracellular] + ATP + H2O = H(+)[extracellular] + ADP + phosphate.; Function: a proton gradient across the plasma membrane is important for many proton-driven transport functions.; Function: pmaA of A. nidulans is involved in proton homeostasis and establishment/maintanance of a proton gradient across the plasma membrane.; Remark: a putative sequencing error results in a frameshift.; Title: strong similarity to plasma membrane H(+)-ATPase pmaA - Aspergillus nidulans [putative frameshift]; plasma membrane; putative frameshift; See PMID 11131024
An02g12530	Title: questionable ORF
An02g12550	Title: questionable ORF
An02g12590	Title: questionable ORF
An02g12600	Similarity: belongs to the family of metal-dependent hydrolases of the beta-lactamase superfamily II.; Title: similarity to hypothetical hydrolase MJ0301 -Methanococcus jannaschii
An02g12610	Function: Rna1 of S. pombe regulates the activity of Ran-GTPase which is involved in the control of nuclear-cytoplasmic export/import.; Localization: Rna1 of S. pombe is concentrated around the nucleus.; Phenotype: rna1 mutants of S. pombe are impaired in processing and/or export of RNA (all types) from the nucleus.; Similarity: the A. niger protein, like Rna1 of S. pombe, contains a leucine rich repeat domain and an acid rich region in the C-terminal part of the sequence.; Title: strong similarity to Ran-GTPase-activating protein 1 rna1p - Schizosaccharomyces pombe; cytoplasm; See PMID 8374168; See PMID 9121474
An02g12620	Function: Cox17p of S. cerevisiae shuttles Cu(I) ions to the mitochondrial intermembrane space, which is necessary for the assembly of functional cytochrome c oxidase.; Function: Cu(I) ions in Cox17p of S. cerevisiae are liganded in a binuclear cuprous cysteinyl-thiolate cluster.; Phenotype: mutations in the COX17 gene of S. cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex.; Similarity: nearly identical to Aspergillus niger EST SEQ ID NO:4014 of patent WO200056762-A2 (PATENTDNA:AAF11491).; Title: strong similarity to copper metallochaperone Cox17 - Saccharomyces cerevisiae [putative sequencing error]; cytoplasm; putative sequencing error; See PMID 8662933; See PMID 9407107; See PMID 9585572; See PMID 10970896
An02g12630	Catalytic activity: glucosyl-dolichyl-phosphate + Man9GlcNAc2-dolichyl-pyrophosphate = dolichyl-phosphate + Glc1Man9GlcNAc2-dolichyl-pyrophosphate.; Function: Alg6p of S. cerevisiae is involved in the synthesis of the dolichyl pyrophosphate-linked oligosaccharide precursor.; Pathway: Alg6p of S. cerevisiae is involved in the N-glycosylation pathway.; Title: strong similarity to glucosyltransferase Alg6 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8877369
An02g12640	Function: High levels of CP-RBP30 mRNA was found in leaves but not in roots.; Remark: CP-RBP30 and is targeted to chloroplasts.; Title: strong similarity to RNA-binding protein 30 -Nicotiana plumbaginifolia; nucleus; See PMID 1406585
An02g12650	Remark: ORF 5'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.
An02g12670	Catalytic activity: gamma-glutamyltransferases convert (5-L-glutamyl)-peptide + an amino acid to peptide + 5-L-glutamyl-amino acid.; Function: B. subtilis ggt catalyzes the transfer of the gamma-glutamyl group from gamma-glutamyl compounds (such as glutathione) to amino acids, peptide acceptors, or H(2)O.; Function: B. subtilis ggt plays a major role in glutathione (L-g-glutamyl-L-cysteinylglycine) metabolism and is involved in polyglutamate production.; Function: glutathione is involved in the maintenance of protein thiol group status and reduction of highly reactive forms of oxygen and free radicals.; Function: in bacteria and mammals ggt is the only protease known to cleave intact glutathione.; Localization: mammalian ggt is located at the external surface of epithelial cells.; Title: similarity to NR-1 gamma-glutamyltranspeptidase ggt - Bacillus subtilis; See PMID 10392451; See PMID 8763966
An02g12680	Catalytic activity: acetylornithine deacetylases convert N2-acetyl-L-ornithine + H(2)O to acetate + L-ornithine.; Function: M. xanthus argE is involved in arginine biosynthesis.; Title: similarity to acetylornithine deacetylase argE - Myxococcus xanthus; See PMID 9829957
An02g12690	Similarity: the predicted A. niger protein shows similarity to several hypothetical isochorismatases and contains a isochorismatases motif.; Title: similarity to hypothetical protein yaaI -Escherichia coli
An02g12700	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g12710	Title: weak similarity to hypothetical protein encoded by An17g00030 - Aspergillus niger
An02g12720	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g12730	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g12740	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An02g12750	Alternative name: an alternativ name for the S. cerevisiae Cct chaperonin complex is TCP-1.; Complex: in S. cerevisiae CCT1-8 form the Cct chaperonin complex.; Function: S. cerevisiae CCT8 is a subunit of the Cct chaperonin complex which binds to newly synthesized actin and tubulin and can convert these proteins into an assembly-competent state.; Localization: S. cerevisiae CCT localized to the cytoplasm and the cell cortex.; Similarity: S. cerevisiae CCT shows similarity to GroEl.; Title: strong similarity to cytoskeleton specific chaperonin subunit Cct4 - Saccharomyces cerevisiae; See PMID 7865875; See PMID 7916461; See PMID 8771707
An02g12760	Function: S. cerevisiae Rpt1p is one of 6 different ATPases of the 17 subunit regulatory particle of the 26S proteasome.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt1 - Saccharomyces cerevisiae; See PMID 9584156; See PMID 10872471
An02g12770	Remark: S. cerevisiae SDH1 is the flavoprotein subunit of the mitochondrial matrix succinate dehydrogenase heterotetramer.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2833 and an_1386.; Title: strong similarity to succinate dehydrogenase Sdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9929002
An02g12780	Function: S. cerevisiae WSC2 is a plasme membrane localised regulator of the PKC1-MPK1 pathway.; Similarity: similarity of the predicted A. niger protein to S. cerevisiae WSC2 is mostly due to serine repeats.; Title: weak similarity to cell wall integrity and stress response factor Wsc2 - Saccharomyces cerevisiae; See PMID 9391108
An02g12790	Catalytic activity: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylases convert 5-oxopent-3-ene-1,2, 5-tricarboxylate to 2-oxohept-3-enedioate + CO(2).; Function: E. coli hpcE is a 5-carboxymethyl-2-hydroxymuconate delta-isomerase and 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase.; Function: E. coli hpcE is involved in the utilisation of homoprotocatechuate and hydroxyphenylacetate.; Title: similarity to bifunctional OPET decarboxylase/HHDD isomerase hpcE - Escherichia coli; See PMID 8223600
An02g12800	Catalytic activity: gentisate 1,2-dioxygenases convert 2,5-dihydroxybenzoate + O(2) to maleylpyruvate.; Complex: P. alcaligenes gdo is a homodimer.; Function: P. alcaligenes gdo is involved in the utilisation of 3-hydroxybenzoate as a carbon source.; Induction: P. alcaligenes gdo is 3-hydroxybenzoate-inducible.; Title: similarity to gentisate 1,2-dioxygenases gdo - Pseudomonas alcaligenes; See PMID 10049846
An02g12810	Title: weak similarity to protein SEQ ID NO: #2154 from patent US6562958-B1 - Acinetobacter baumannii
An02g12820	Catalytic activity: Aryl-alcohol dehydrogenases convert an aromatic alcohol + NAD(+) to an aromatic aldehyde + NADH.; Function: Acinetobacter areB is involved in the catabolism of aromatic alcohol esters, accepting a range of substituted aromatic compounds as substrate.; Induction: expression of Acinetobacter areB is induced by benzyl acetate, benzyl alcohol, and benzaldehyde, as well as 2- and 4-hydroxybenzyl acetates and benzyl propionate and butyrate.; Title: strong similarity to benzyl alcohol dehydrogenase areB - Acinetobacter sp. [putative sequencing error]; putative sequencing error; See PMID 10419955; See PMID 11114944
An02g12830	Similarity: similarity is between the central regions of the predicted A. niger protein and F. solani CTF1.; Title: similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694
An02g12840	Remark: ORF 5'truncated due to end of contig, the N-terminal region is represented by the predicted ORF An02g12850.
An02g12850	Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein probably only retrieves random hits to proline rich proteins.; Title: weak similarity to SH3 domain binding protein CR16 - Rattus norvegicus [truncated ORF]; See PMID 8839352; See PMID 8906616
An02g12890	Remark: blastp with the predicted A. niger protein only retrieves random hits to glycine rich proteins.
An02g12900	Title: similarity to hypothetical protein encoded by An04g10150 - Aspergillus niger
An02g12910	Title: weak similarity to hypothetical protein PM0349 - Pasteurella multocida
An02g12920	Remark: C-terminal region and 3'UTR of the predicted A. niger protein are in accordance with A. niger EST AN07F11 EMBLEST:ANI239976.; Similarity: the predicted A. niger protein shows similarity to several hypothetical ABC-transporter proteins and contains an unusual kinase domain.; Title: strong similarity to hypothetical protein SPAC10F6.14c - Schizosaccharomyces pombe
An02g12930	Function: S. aureofaciens tcrC is a tetracycline efflux pump of the major facilitator familiy.; Title: similarity to tetracycline efflux pump tcrC -Streptomyces aureofaciens; plasma membrane; See PMID 8534971
An02g12940	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_ 3344.; Title: strong similarity to EST an_3344 -Aspergillus niger
An02g12950	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility factor het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An02g12960	Remark: C-terminal region and 3'UTR of the predicted A. niger protein are covered by the A. niger EST an_2701 .; Remark: ORF 5'truncated due to end of contig, the N-terminal region is represented by the predicted ORF An02g12970.; Similarity: the predicted A. niger protein shows weak similarity to proline rich proteins.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens [truncated ORF]
An02g12970	Localization: C. thermocellum ancA is a cell surface protein.; Remark: ORF 3'truncated due to end of contig, the C-terminal region is represented by the predicted ORF An02g12960.; Similarity: the predicted A. niger protein shows weak similarity to several extracellular and cell wall associated proline rich exo-alpha-sialidases.; Title: weak similarity to cellulosome attachment protein ancA - Clostridium thermocellum [truncated ORF]; See PMID 8458832
An02g12980	Function: S. cerevisiae Sed5p has an essential role in vesicular transport between ER and Golgi compartments.; Golgi; Localization: immuno-EM reveals that the majority of S. cerevisiae Sed5p is in a tubulo-vesicular compartment on the cis side of the Golgi apparatus.; Similarity: S. cerevisiae Sed5 is a member of the syntaxin family.; Title: strong similarity to cis-Golgi t-SNARE Sed5 -Saccharomyces cerevisiae; See PMID 10515003; See PMID 1400588; See PMID 7929581
An02g12990	Title: weak similarity to hypothetical translation initiation factor IF-2 F28O16.19 - Arabidopsis thaliana
An02g13030	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An02g13040	Function: Xanthobacter Py2 XamoC is one of 6 subunits of the alkene monooxygenase Xamo, which oxidizes benzene, toluene, and phenol converting them to carbon sources.; Title: weak similarity to ferredoxin aamC -Xanthobacter sp.; See PMID 10103255
An02g13050	Remark: Alterations of the azole target enzyme and the overexpression of multidrug efflux transporter genes are the most frequent azole resistance mechanisms in Candida albicans.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An02g13060	Title: weak similarity to hypothetical DNA gyrase subunit A VC1258 - Vibrio cholerae
An02g13080	Catalytic activity: Indoleacetate-lysine ligases convert ATP + indole-3-acetate + L-lysine to ADP + n6-[(indole-3-yl)acetyl]-L-lysine.; Function: P. savastanoi iaaL converts the plant gall inducing indole-3-acetate (iaa) to iaa-lysine.; Similarity: P. savastanoi iaaL shows similarity to other enzymes which act via an ATP-dependent covalent binding of AMP to their substrate.; Title: similarity to N epsilon-(indole-3-acetyl)-L-lysine synthase iaaL -Pseudomonas syringae; See PMID 2377619
An02g13090	Function: C. carbonum TOXG encodes an alanine racemase whose function is to convert L-Ala to D-Ala for incorporation into HC-toxin.; Title: strong similarity to alanine racemase TOXG -Cochliobolus carbonum; See PMID 10671527
An02g13100	Title: weak similarity to transcription activator Ppr1 - Saccharomyces cerevisiae; See PMID 6096561
An02g13110	Remark: blastp with the predicted A. niger protein mostly retrieves random hits to proline rich proteins.; Title: weak similarity to aortic carboxypeptidase-like protein ACLP from patent WO9921965-A2 - Homo sapiens
An02g13120	Title: strong similarity to hypothetical protein encoded by An04g08050 - Aspergillus niger
An02g13130	Similarity: the predicted A. niger protein contains a neutral zinc metallopeptidases, zinc-binding region signature.; Title: strong similarity to hypothetical protein CAC18209.1 - Neurospora crassa
An02g13140	Title: strong similarity to hypothetical protein EAA60090.1 - Aspergillus nidulans
An02g13150	Function: A. nidulans palI mutations mimic the effects of acidic growth pH and homology of PalI to S. cerevisiae Rim9p meiotic signal transduction component suggest that PalI might be a membrane sensor for ambient pH.; Title: similarity to membrane sensor for ambient pH palI - Aspergillus nidulans; See PMID 7830727; See PMID 9791171
An02g13160	Function: C. albicans CFL1 is a surface-associated ferric reductase involved in iron homeostasis.; Function: C. albicans CFL1 is able to complement mutations in the S. cerevisiae cell surface metalloreductases fre1 that is required for reduction and uptake of free ferric iron.; Regulation: C. albicans CFL1 is regulated in response to levels of iron and copper.; Title: similarity to ferric reductase CFL1 - Candida albicans; plasma membrane; See PMID 10784045; See PMID 11120744
An02g13180	Function: T. harzianum lam1. 3 is a lytic enzyme involved in degradation of host cell walls, enabling utilisation of both their cell walls and cellular contents for nutrition.; Title: strong similarity to beta-1,3-exoglucanase lam1.3 - Trichoderma atroviride; extracellular/secretion proteins; See PMID 9931476
An02g13190	Title: strong similarity to hypothetical protein 7C14.090 - Neurospora crassa
An02g13200	Remark: blastp with the predicted A. niger protein mostly retrieves random hits to serine, proline, threonine and glutamine rich proteins.; Similarity: the N-terminus of the predicted A. niger protein contains a Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to hypothetical transcription factor CAB91400.2 - Neurospora crassa
An02g13210	Function: human LUCA15 specifically bound poly(G) RNA homopolymers in vitro and its ectopic expression suppressed the cell growth.; Regulation: LUCA15 is one of the down-regulated genes in ras-transformed cells.; Title: similarity to RNA-binding tumour suppressor LUCA15 - Homo sapiens; See PMID 10353602; See PMID 11029660
An02g13220	Catalytic activity: Lysophospholipases convert 2-lysophosphatidylcholine + H(2)O to glycerophosphocholine + a fatty acid anion.; Function: P. notatum phospholipase B has lysophospholipase and phospholipase B activity, however by endogenous proteolytic modification, its phospholipase B activity is lost almost completely, whereas its lysophospholipase activity remains unchanged.; Remark: similar phospholipase B proteins from C. albica and A. fumigatus are secreted virulence factors.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1710.; Title: strong similarity to lysophospholipase phospholipase B - Penicillium notatum; See PMID 9580028; See PMID 10627494; See PMID 1722456
An02g13230	Remark: all other members of this family are 3 fold longer.; Similarity: to proteins of the tenascin family.; Title: weak similarity to tenascin-X Tnx - Mus musculus
An02g13240	Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: the described cluster in A. parasiticus has no similar well-defined sugar gene cluster has been reported so far in any other related Aspergillus species such as A. flavus, A. nidulans, A. sojae, A. niger, A. oryzae and A. fumigatus.; Remark: this single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharides, which are hydrolysed relatively slowly, or not at all.; Title: strong similarity to alpha-1-6-glucosidase glcA - Aspergillus parasiticus; See PMID 10978525
An02g13250	Remark: water transport in highly water-permeable membranes is conducted by water-selective pores namely,water channels. AQP3 in rat may function as a water and urea exit mechanism in antidiuresis in collecting duct cells.; Similarity: to the aquaporins of different eukaryotes.; Title: strong similarity to water channel protein aquaporin 3 AQP3 - Rattus norvegicus; See PMID 8063828; See PMID 7517548; See PMID 7526388
An02g13270	Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: phenylalanine metabolism.; Remark: the A. niger protein requires Fe2+ and tetrahydrobiopterin.; Similarity: to the cytochrome P450 superfamily.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 2250647
An02g13280	Similarity: the ORF shows strong similarity to another A. niger protein.; Title: similarity to hypothetical protein AAN59045.1 - Streptococcus mutans
An02g13290	Function: ARGR2 of S. cerevisiae is a regulator of arginine-responsive genes together with ARG80 and ARG82.; Remark: ARGR2 of S. cerevisiae is also called ARG81.; Similarity: only the N-terminus of fungal transcriptional regulatory proteins containing the zinc-finger domain is similar to the ORF sequence.; Title: similarity to transcription factor Arg81 -Saccharomyces cerevisiae; See PMID 7985419; See PMID 10436161; See PMID 789352
An02g13300	Title: similarity to hypothetical protein ID880 -Bradyrhizobium japonicum
An02g13310	Title: strong similarity to hypothetical protein Rv0976c - Mycobacterium tuberculosis
An02g13320	Remark: the homolog proteins match only with the N-terminal parts, and are shorter.; Title: similarity to gentisate 1,2-dioxygenase xlnE - Pseudomonas alcaligenes; See PMID 10049846
An02g13330	Remark: Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: contains a zn(2)-cys(6), fungal-type binuclear cluster domain.; Title: similarity to thiamine repressible gene thi1p - Schizosaccharomyces pombe; See PMID 8088540
An02g13340	Remark: strong similarity to BAA-BEST1 from Hordeum sp. patent WO9902703-A1.; Similarity: also strong similarity to para-nitrobenzyl esterases and acetylcholinesterases.; Title: strong similarity to fumonisin esterase BAA-BEST1 from patent WO9902703-A1 - Hordeum sp.
An02g13350	Remark: molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway present in eubacteria,archaea and eukaryotes, including humans.; Similarity: to molybdopterin-converting factor chain 2.; Title: strong similarity to molybdopterin synthase large subunit cnxH - Aspergillus nidulans; See PMID 10383438; See PMID 11135669
An02g13360	Remark: the yeast nuclear SCO1 gene is required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of cox.; Similarity: the protein belongs to the SCO1/2 protein family.; Title: strong similarity to assembly factor of cytochrome c oxidase Sco1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11086158; See PMID 2543907
An02g13370	Title: strong similarity to hypothetical protein 7C14.100 - Neurospora crassa
An02g13380	Remark: due to repetitiv sequences it is only weak similarity.; Title: weak similarity to gastric mucin clone PGM-2A - Sus scrofa; See PMID 7506218
An02g13390	Remark: caYAE1 is used to produce e. g. recombinant protein and DNA vaccination, for treating candidosis.; Remark: similarity to caYAE1 protein YAE1 from Candida albicans patent EP844307-A1.; Title: similarity to caYAE1 protein YAE1 from patent EP844307-A1 - Candida albicans
An02g13400	Remark: weak similarity to O antigen abe gene protein from Salmonella enterica patent WO9850531-A1.; Title: weak similarity to antigen abe from patent WO9850531-A1 - Salmonella enterica
An02g13410	Remark: AT-1 protein functions as an Ac-CoA transporter, and may play a key role in acetylation processes of gangliosides.; Remark: the protein seems approximately 200 aa to short.; Remark: the protein shows also similarity to Acetyl-coenzyme A transporter (AT) protein from Homo sapiens patent US5851788-A and WO9833816-A1.; Title: similarity to acetyl-coenzyme A transporter AT-1 - Homo sapiens; See PMID 9096318
An02g13420	Title: strong similarity to hypothetical protein EAA60070.1 - Aspergillus nidulans
An02g13430	Remark: all found homology proteins are longer.; Title: weak similarity to trichohyalin TRHY - Homo sapiens; See PMID 7685034
An02g13440	Remark: the protein shows strong similarity to carboxylic ester hydrolases, the substrate specifity is unkown cause it shows both similarity to carboxylesterases and to triacylglycerol lipases.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382
An02g13450	Title: weak similarity to protein CAP59 -Cryptococcus neoformans
An02g13460	Function: pcpl3 of s. cerevisiae mediates the active transport of purines and cytosine.; Title: strong similarity to purine-cytosine permease pcpl3 - Kluyveromyces marxianus; See PMID 10943566
An02g13470	Title: similarity to hypothetical protein CAD60573.1 - Podospora anserina
An02g13480	Title: similarity to hypothetical protein B2J23.40 -Neurospora crassa
An02g13490	Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: norA of A. parasiticus is genomically localized within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conductive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042
An02g13500	Title: strong similarity to hypothetical protein Mx - Anas platyrhynchos; See PMID 8100373; See PMID 9360386
An02g13510	Similarity: the ORF encoded protein shows also strong similarity to the hypothetical proteins YIL083c (S. cerevisiae) and SPCC4B3. 18 (S. pombe).; Title: strong similarity to polypeptide SEQ ID NO:41022 from patent WO200171042-A2 - Drosophila melanogaster
An02g13520	Title: similarity to hypothetical protein CAC41653.1 - Ustilago maydis
An02g13530	Catalytic activity: chitin + H(2)O <=> chitosan + acetate.; Title: similarity to peptidoglycan N-acetylglucosamine deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617
An02g13540	Function: the Ded1 protein from S. cerevisiae is a ATP-dependent RNA helicase and plays a role in translation initiation.; Remark: S. cerevisiae Ded1 is essential for cell viability.; Remark: alternate name for S. cerevisiae Ded1: Spp81 or YOR204W.; Similarity: the ORF encoded protein shows also strong similarity to the ATP-dependent RNA helicase DBP1 (YPL119C) from S. cerevisiae.; Title: strong similarity to ATP-dependent RNA helicase Ded1 - Saccharomyces cerevisiae; See PMID 9144215; See PMID 10364207
An02g13550	Catalytic activity: ATP + pantothenate <=> ADP + D-4'-phosphopantothenate.; Pathway: the pantothenate kinase PanK from Emericella nidulans is involved in first step in coenzyme A (CoA) biosynthesis.; Title: strong similarity to pantothenate kinase panK - Aspergillus nidulans; See PMID 9890959
An02g13560	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to nucleolar protein gar2p -Schizosaccharomyces pombe
An02g13570	Function: the human pig-C protein is involved in the first step of glycosylphosphatidylinositol synthesis which is the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol.; Remark: Glycosylphosphatidylinositol (GPI) protein anchors are ubiquitous in eukaryotic cells. GPI anchors are synthesized in the endoplasmic reticulum by actions of ten or more gene products. The first step of the biosynthesis,the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol.; Similarity: pig-C is the human Gpi2 (S. cerevisiae) homolog.; Title: strong similarity to protein involved in glycosylphosphatidylinositol biosynthesis pig-C - Homo sapiens; endoplasmatic reticulum; See PMID 8806613; See PMID 9463366
An02g13580	Function: an endochitinase the catalyzes hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Title: strong similarity to endochitinase from patent EP531218-A - Aphanocladium album
An02g13590	Function: Pseudomonas tolaasii is the causal agent of brown blotch disease of Agaricus bisporus. The PheN sensor regulator is responsible for the phenotypic switch from the smooth, pathogenic form (designated 1116S) to the rough non-pathogenic form (designated 1116R) of P. tolaasii.; Remark: N-terminally truncated ORF due to the end of contig.; Similarity: the PheN protein from Pseudomonas tolaasii has sensor and regulator domains. It belongs to the conserved family of two component bacterial sensor regulator proteins.; Title: strong similarity to two component sensor regulator PheN - Pseudomonas tolaasii [truncated ORF]; See PMID 7642492; See PMID 9282733
An02g13600	Function: is involved in the uptake of histidinol and other cations.; Remark: alternate name for S. cerevisiae Hol1 is YNR055c.; Similarity: the ORF encoded protein shows also strong similarity to the major facilitator superfamily of transporters.; Title: strong similarity to the cation transporter Hol1 - Saccharomyces cerevisiae; See PMID 8955402
An02g13620	Title: weak similarity to hypothetical protein ORF-c18_019 - Sulfolobus solfataricus
An02g13630	Title: strong similarity to hypothetical protein CC0505 - Caulobacter crescentus
An02g13640	Function: the Slg1 protein from S. cerevisiae is proposed to play a regulatory role in bud emergence or stationary phase.; Localization: Epitope-tagged Slg1p cofractionated with the plasma membrane.; Remark: alternate names for S. cerevisiae Slg1: Wsc3 or YOL105C.; Similarity: the similarities of the ORF encoded protein to some matching proteins are mainly based on repetitive structures.; Title: similarity to cell cycle relevant protein Slg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10660075
An02g13660	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to extracellular matrix protein papilin Ppn - Drosophila melanogaster
An02g13670	Title: similarity to human secreted protein fragment from patent WO9909155-A1 - Homo sapiens
An02g13680	Complex: a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing.; Function: the SRm160/300 splicing coactivator functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA, including snRNPs and SR family proteins.; Remark: SRM160 is a serine (S) and arginine (R)-rich protein.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10668804
An02g13700	Title: weak similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans
An02g13710	Title: weak similarity to Slg1 - Saccharomyces cerevisiae
An02g13740	Catalytic activity: release of a C-terminal amino acid from a peptide in which glycine is the penultimate amino acid.; Pathway: yscS is a member of the peptidases in S. cerevisiae involved in nitrogen metabolism.; Repression: transcriptional repression of yscS in yeast cells grown on rich nitrogen sources.; Similarity: yscS belongs to peptidase family M20A.; Title: strong similarity to Gly-X carboxypeptidase precursor Yscs - Saccharomyces cerevisiae; vacuole; See PMID 2026161; See PMID 7700231
An02g13750	Catalytic activity: glutamine is hydrolysed to glutamate and ammonium.; Remark: purified glutaminase gtaA catalyses the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006
An02g13770	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An02g13780	Title: weak similarity to hypothetical protein F22O6.70 - Arabidopsis thaliana
An02g13790	Complex: a purified Drosophila septin complex comprised of the three septin polypeptides Pnut, Sep2, and Sep1 forms filaments and exhibits GTPase activity.; Function: septin proteins such as Sep1 are necessary for cytokinesis in Drosophila.; Similarity: Sep1 is a member of the GTPase superfamily.; Title: similarity to septin protein Sep1 -Drosophila melanogaster; See PMID 9751888; See PMID 8636235
An02g13800	Similarity: the ORF shows similarity to an A. niger sequence clone 2457. The sequence deviates in overall length as well as in two positions in the matching region from the sequence of the genomic DNA.; Title: strong similarity to hypothetical membrane protein YPR157w - Saccharomyces cerevisiae
An02g13810	Function: dodA encodes a type of aromatic ring-cleaving dioxygenase involved in betalain biosynthesis in Amanita muscaria.; Induction: regulation occurs at the transcriptional level; the mRNA accumulates to high levels only in the coloured cap tissue.; Title: similarity to DOPA-dioxygenase dodA - Amanita muscaria; See PMID 9341673
An02g13820	Title: weak similarity to tight junction protein ZO-1 - Hydra vulgaris
An02g13830	Title: similarity to hypothetical protein CAE76380.1 - Neurospora crassa
An02g13840	Complex: S9 is a protein of the cytosolic small ribosomal (40S)-subunit.; Function: S9 is involved in protein biosynthesis.; Similarity: S9 belongs to the S4P family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S9 - Homo sapiens; cytoplasm; See PMID 7772601
An02g13850	Complex: URP1 is a protein of the cytosolic large ribosomal (60S)-subunit.; Function: URP1 is involved in protein biosynthesis.; Similarity: URP1 is a homolog of rat ribosomal protein gene L21.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Urp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7871891; See PMID 8428379
An02g13860	Title: weak similarity to neurofilament triplet H protein NF-H - Rattus norvegicus
An02g13870	Remark: silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated.; Similarity: SAS2 bears similarities to known protein acetyltransferases.; Similarity: SAS2 belongs to the MYST family and members of this family are implicated in acute myeloid leukemia (MOZ), transcriptional silencing in yeast (SAS2 and YBF2/SAS3), HIV Tat interaction in humans (Tip60).; Title: similarity to transcription silencing protein Sas2 - Saccharomyces cerevisiae; See PMID 8782818; See PMID 9093847
An02g13880	Function: cdc5 might encode a transcription factor whose activity is required for cell cycle progression and growth during G2.; Phenotype: a cdc5 mutant arrests with a 2N DNA content and a single interphase nucleus.; Similarity: cdc5 contains a region sharing significant homology with the DNA binding domain of the myb family of transcription factors.; Title: strong similarity to myb-related protein cdc5p - Schizosaccharomyces pombe; See PMID 8313892
An02g13890	Remark: the matching protein is a Jun N-terminal protein kinase (JNK3) binding protein.; Title: similarity to JNK3 binding protein amino acid sequence #8 from patent WO200031132-A1 - Mus sp.
An02g13900	Function: RNH70 is involved in DNA replication and RNA processing.; Phenotype: deletion of RNH70 from the yeast genome did not result in any serious phenotype under the conditions tested.; Title: similarity to ribonuclease Rnh70 -Saccharomyces cerevisiae; nucleus; See PMID 10359084; See PMID 10669875
An02g13910	Title: strong similarity to hypothetical protein SPBP4H10.20 - Schizosaccharomyces pombe
An02g13920	Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Complex: the interaction between YUH1 and the yeast ubiquitin protein has been studied by heteronuclear multidimensional NMR spectroscopy.; Function: YUH1, a cysteine protease that catalyzes the removal of ubiquitin C-terminal adducts, is important for the generation of monomeric ubiquitin.; Remark: YUH1 acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin.; Remark: the release of ubiquitin from attachment to other proteins and adducts is critical for ubiquitin biosynthesis, proteasomal degradation and other cellular processes.; Similarity: YUH1 is member of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.; Title: strong similarity to ubiquitin thiolesterase Yuh1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10406793; See PMID 10413498
An02g13930	Remark: the ORF is C-terminally truncated due to end of contig.
An02g13940	Function: SPBP35G2. 14 of S. pombe is similar to PUF proteins of S. cerevisiae which are thought to be involved in the regulation of mRNA stability.; Similarity: contains a RNA recognition motif (RRM) and 5 pumilio-family (PUF) RNA-binding repeats.; Title: strong similarity to hypothetical RNA-binding protein CAA18887.1 - Schizosaccharomyces pombe
An02g13950	Title: weak similarity to hypothetical protein OSJNBa0026A15.6 - Oryza sativa
An02g13960	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g13970	Title: weak similarity to hypothetical glutamate-rich coiled-coil protein CAB87375.1 -Schizosaccharomyces pombe
An02g13980	Phenotype: Disruption of Tri4 resulted in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: Trichothecenes are strong inhibitors of protein synthesis in mammalian cells.; Remark: an alternate name for the F. sporotrichioides trichodiene oxygenase is TRI4.; Remark: the F. sporotrichioides trichodiene oxygenase is part of the fungal trichothecenes and apotrichodiol biosythesis.; Title: strong similarity to trichodiene oxygenase cytochrome P450 CYP58 - Fusarium sporotrichioides; See PMID 7651333
An02g14000	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14020	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14060	Title: questionable ORF
An02g14070	Similarity: the ORF shows strong similarity to the A. niger EST an_2818.; Title: weak similarity to hypothetical protein encoded by An11g01490 - Aspergillus niger
An02g14080	Catalytic activity: the T. aquaticus asparaginyl-tRNA-synthetase converts ATP and L-asparagine and tRNA(Asn) to AMP and diphosphate and L-asparaginyl-tRNA(Asn).; Remark: the T. aquaticus asparaginyl-tRNA-synthetase is remarkably thermostable and retains 50% of its initial tRNA aminoacylation activity after 1 h of incubation at 90 degrees C or 21 h at 85 degrees C.; Title: strong similarity to asparagine--tRNA ligase ASNS - Thermus aquaticus; See PMID 8706760
An02g14090	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14100	Function: TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.; Function: the M. musculus TIA-1 belongs to a family of RNA recognition motif (RRM) proteins which possess four RRM-type (PF00076) RNA binding domains (aa 192-258, 283-358, 417-483, 508-574).; Remark: the M. musculus TIA-1 has been implicated as effector of apoptotic cell death.; Title: similarity to cDNA RNA-binding protein TIA-1 - Mus musculus; See PMID 8871565; See PMID 10921895
An02g14140	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14160	Function: the C. neoformans AP59 gene is required for capsule formation which is a crucial step in the pathogenicity of Cryptococcus neoformans.; Remark: the similarity of the predicted A. niger protein is restricted to the N-terminal half of the protein.; Title: similarity to protein CAP59 - Cryptococcus neoformans; See PMID 8007987
An02g14170	Title: weak similarity to hypothetical protein all7165 - Nostoc sp.
An02g14180	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14190	Similarity: the deduced S. aureofaciens tcr3 amino acid sequence had a high level identity with that of the self-defense gene (tet347) of Streptomyces rimosus, known to mediate oxytetracycline efflux.; Title: similarity to hypothetical self-defense gene tcr3 - Streptomyces aureofaciens; See PMID 8534971
An02g14200	Function: the P. marneffei CflA initiates polarized growth and extension of the germ tube and subsequently maintains polarized growth in the vegetative mycelium.; Remark: heterologous expression of cflA alleles in A. nidulans prevents conidiation.; Similarity: the P. marneffei CflA belongs to the Rho family of GTPases.; Title: strong similarity to CDC42-like protein CflA - Penicillium marneffei; See PMID 11344153
An02g14210	Catalytic activity: the E. coli agmanitase converts agmatine and H2O to putrescine and urea.; Function: the predicted E. coli agmanitase protein is involved in the putrescine biosynthetic pathway and thus in the proline and arginine metabolism.; Remark: an alternate name for the agmanitase is agmatine ureohydrolase.; Title: strong similarity to hypothetical agmanitase - Escherichia coli; See PMID 1310091
An02g14220	Function: the enzyme catalyzes the condensation of malonyl-ACP with the growing fatty acid chain.; Similarity: the E. coli fabJ gene product belongs to the beta-ketoacyl-ACP-synthase familiy.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) synthase fabJ -Escherichia coli; See PMID 7972002
An02g14230	Title: similarity to hypothetical protein SPCC126.04c - Schizosaccharomyces pombe
An02g14240	Catalytic activity: the S. cerevisiae guanyllytransferase converts GTP and (5')PP-pur-mRNA to diphosphate and G(5')PPP-pur-mRNA.; Remark: Can modify also synthetic poly(A) and poly(G) to form the structures M(7)G(5')pppA(N) and M(7)G(5')pppG(N).; Remark: the S. cerevisiae guanyllytransferase is also referred to as mRNA capping enzyme.; Title: strong similarity to mRNA guanylyltransferase - Saccharomyces cerevisiae; See PMID 1315757
An02g14260	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An02g14280	Title: similarity to hypothetical membrane protein YPR157w - Saccharomyces cerevisiae
An02g14290	Function: the R. toruloides cephalosporin esterase hydrosyses the acetyl estyl bond on the 10-position of the antibiotic cephalosporin C, producingDeacetylcephalosporin and acetate.; Pathway: the cephalosporin cleavage is part of the penicillin and cephalosporin metabolism.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399
An02g14300	Function: pth11 of M. grisea is involved in host surface recognition.; Similarity: the ORF is about 260 amino acids shorter than pth11 of M. grisea.; Similarity: the ORF is shorter than pth11 of M. grisea (391 compared to 631 amino acids).; Similarity: the ORF shows similarity to the EST seq id no:6959 of patent WO200056762-A2 - Aspergillus oryzae; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea
An02g14310	Remark: an alterntative gene name for PHF2 is GRC5.; Title: strong similarity to PHD-finger protein PHF2 - Homo sapiens
An02g14330	Title: strong similarity to hypothetical protein HSPC175 - Homo sapiens
An02g14340	Complex: the U5 snRNP is part of the splicosome.; Remark: SNU13 of S. cerevisiae constitutes the U4/U6. U5 snRNP (small nuclear ribonucleoprotein particle) component.; Remark: SNU13 of S. cerevisiae is also called YEL026w.; Similarity: strong similarity to ribosomal protein L7a superfamily.; Similarity: the ORF shows strong similarity to the A. niger EST no:3887 of patent WO200056762-A2.; Title: strong similarity to RNA-binding protein Snu13 - Saccharomyces cerevisiae; See PMID 11720284
An02g14350	Similarity: the ORF shows strong similarity to expressed sequence tag an_2353 from Aspergillus niger.; Title: strong similarity to hypothetical protein B14D6.530 - Neurospora crassa
An02g14360	Title: strong similarity to hypothetical protein SPBC29A3.06 - Schizosaccharomyces pombe
An02g14380	Catalytic activity: ATP + D-hexose <=> ADP + D-hexose 6-phosphate.; Function: A. niger hxk is responsible for phosphorylation of glucose and fructose. D-Glucose, the glucose analogue 2-deoxy-D-glucose, D-fructose, D-mannose and D-glucosamine are phosphorylated by hexokinase, whereas the hexoses D-galactose, L-sorbose, methyl alpha-D-glucoside and the pentoses L-arabinose and D-xylose are not.; Gene-ID: hxk; Mapping: hxk from A. niger is mapped to chromosome VI; see EMBL AJ009973.
An02g14390	Complex: Sir2p is one of four Silent Information Regulator genes in yeast. Sir2p (but not the other Sir proteins) is a component of the nucleolar complex called RENT, a regulator of nucleolar silencing and telophase exit.; Function: the S. cerevisiae homolog Sir2p is a NAD-dependent histone deacetylase and participates in maintenance of silencing of HMR, HML and telomeres. unlike repressors that act by binding to promoters, the Sir proteins help repress transcription by creating a silent chromatin stucture in a gene- and promoter-independent manner. the Sir proteins do not bind DNA directly, but rather seem to act via histones and other DNA binding proteins.; Title: strong similarity to regulator protein Sir2 -Saccharomyces cerevisiae; nucleus
An02g14400	Title: strong similarity to hypothetical protein SPCC338.13 - Schizosaccharomyces pombe
An02g14410	Function: the S. cerevisiae homolog Mep3p is an ammonia permease of high capacity and low affinity.; Repression: the S. cerevisiae MEP genes are subject to nitrogen control, in the presence of a good nitrogen source, all three MEP genes are repressed.; Similarity: shows sequence similarity to S. cerevisiae Mep1p and Mep2p.; Title: strong similarity to ammonium transport protein Mep3 - Saccharomyces cerevisiae
An02g14450	Function: pmrA is a P-type Ca(2+)-ATPases with a high degree of sequence similarity to the Pmr1 proteins from yeasts and mammalians and is involved in in Ca(2+) and Mn(2+) homeostasis in A. niger.; Gene-ID: pmrA
An02g14460	Function: the S. pombe homolog rad21 is a gene essential in mitotic growth that is involved in DNA double-strand-break repair. Further functions of rad21 are related to chromosome segregation and microtubule function.; Title: strong similarity to double-strand-break repair protein rad21p - Schizosaccharomyces pombe; nucleus
An02g14470	Remark: MDR1 of C. albicans is also called BMR.; Similarity: the ORF shows similarity to multiple drug resistance proteins from several species.; Title: strong similarity to benomyl/methotrexate resistance protein MDR1 - Candida albicans; plasma membrane; See PMID 9745021
An02g14490	Title: strong similarity to hypothetical protein B24B19.80 - Neurospora crassa
An02g14500	Similarity: the ORF shows strong similarity to the A. niger EST an_3015.; Title: similarity to hypothetical protein encoded by An11g03520 - Aspergillus niger
An02g14520	Catalytic activity: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O <=> AMP + diphosphate + GMP + L-glutamate.; Function: the S. cerevisiae homolog Gua1p is a GMP synthetase which catalyzes the amination of xanthine monophosphate to guanine monophosphate in the guanine branch of the purine biosynthesis pathway.; Pathway: GMP biosynthesis pathway.; Title: strong similarity to GMP synthase (glutamine-hydrolyzing) Gua1 - Saccharomyces cerevisiae
An02g14530	Title: strong similarity to electron transfer protein ETRN-4 from patent WO200105969-A2 - Homo sapiens
An02g14540	Title: strong similarity to hypothetical protein PA2682 - Pseudomonas aeruginosa
An02g14550	Title: strong similarity to hypothetical protein SPBC1861.05 - Schizosaccharomyces pombe
An02g14560	Complex: ostA is the alpha-chain of the A. niger oligosaccharyltransferase.; Function: the oligosaccharyltransferase complex catalyzes the asparagine-linked glycosylation of proteins in the lumen of the endoplasmic reticulum.; Gene-ID: ostA
An02g14590	Catalytic activity: L-glutamate + H(2)O + NAD(+) <=> 2-oxoglutarate + NH(3) + NADH.; Complex: S. cerevisiae Gdh2p forms a homotetramer.; Function: the S. cerevisiae homolog Gdh2p is a NAD-dependent glutamate dehydrogenase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to glutamate dehydrogenase Gdh2 - Saccharomyces cerevisiae
An02g14600	Function: the N. crassa homolog CIA84 is a nuclear encoded, mitochondria targeted chaperone involved in the in the assembly of mitochondrial NADH:ubiquinone oxidoreductase (complex I).; Title: strong similarity to NADH:ubiquinone reductase intermediate-associated protein CIA84 -Neurospora crassa; See PMID 9769214
An02g14610	Function: ribosomal protein S18 is involved in the binding of fMet-tRNA, and hence the initiation of translation.; Similarity: shows similarity to the ribosomal subunit S18 of several species.; Title: similarity to ribosomal protein of the small subunit S18 rpsR - Escherichia coli; See PMID 6210737; See PMID 10094780
An02g14620	Complex: the S. cerevisiae homolog Aip1p interacts with the ubiquitous actin depolymerizing factor cofilin.; Function: S. cerevisiae Aip1p is a cofilin-associated protein that enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.; Title: strong similarity to actin interacting protein Aip1 - Saccharomyces cerevisiae; cytoskeleton
An02g14630	Title: strong similarity to hypothetical protein CAD37054.1 - Neurospora crassa
An02g14640	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:5842 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to transcriptional coactivator HFI1 related protein CAD71048.1 - Neurospora crassa
An02g14650	Function: the S. pombe homolog prp1 is involved in in pre-mRNA splicing, cell cycle progression and/or poly(A)+ RNA nuclear export.; Title: strong similarity to hypothetical pre-mRNA splicing factor prp1p - Schizosaccharomyces pombe
An02g14660	Function: the S. cerevisiae homolog Dim1p is an essential protein responsible for m6[2]Am6[2]A dimethylation in 3'-terminal loop of 18S rRNA.; Title: strong similarity to rRNA (adenine-N6,N6-)-dimethyltransferase Dim1 - Saccharomyces cerevisiae
An02g14670	Similarity: the N. crassa homolog 2E4. 120 shows similarity to GYP1, the GTPase activating protein for Ypt1p and Sec4p.; Title: strong similarity to hypothetical protein 2E4.120 - Neurospora crassa
An02g14680	Remark: a splice site was detected upstream of the START codon.
An02g14690	Complex: S. cerevisiae Hrp1p is one of five subunits of cleavage factor I (CF I), which is required for cleavage activity in vitro when mixed with CF II and for specific polyadenylation when mixed with polyadenylation factor I.; Function: the S. cerevisiae homolog Hrp1p is involved in cleavage and polyadenylation of mRNA 3' ends.; Title: strong similarity to heterogeneous nuclear ribonucleoprotein Hrp1 - Saccharomyces cerevisiae; nucleus
An02g14710	Function: the N. crassa SPRAY protein is supposed to be located in an organellar membrane, regulating the distribution of Ca(2+) via calcineurin.; Phenotype: the N. crassa spray mutant is sensitive to calcineurin inhibitors.; Remark: between the contig-sequence positions 193548 - 193933 one or more introns may be missing (contig DNA sequence deduced from cDNA).; Title: strong similarity to hypothetical calcium-related spray protein - Neurospora crassa; See PMID 11343401
An02g14720	Function: the predicted A. vitis protein ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate into bacteria.; Title: strong similarity to hypothetical tartrate transport protein ttuB - Agrobacterium vitis; See PMID 7592429
An02g14730	Remark: the expression of the M. musculus IRG1 is altered upon the activation of macrophages by bacterial LPS.; Title: similarity to immune response protein IRG1 -Mus musculus; See PMID 7721348
An02g14750	Remark: actin-related proteins (Arps), which are divergent, but apparently homologues to actin, are categorized into 10 classes.; Similarity: the predicted A. niger protein contains three actin like domains (aa 13-101, 141-221, 323-472) and is therefore showing similarity to a broad range of actin-like proteins.; Title: strong similarity to actin-related protein -Homo sapiens; See PMID 10380635
An02g14770	Title: strong similarity to hypothetical protein EAA62014.1 - Aspergillus nidulans
An02g14790	Function: UNG1 encodes the repair enzyme uracil-DNA-glycosylase.; Phenotype: the UNG1 null mutant is viable.; Similarity: the carboxyl-terminal two-thirds of UNG1 is highly homologous to the entire Escherichia coli enzyme (50% amino acid identity).; Title: strong similarity to uracil-DNA glycosylase Ung1 - Saccharomyces cerevisiae; nucleus; See PMID 2644266
An02g14800	Function: pdiA from A. niger catalyzes the refolding of denatured and reduced RNase A.; Function: pdiA from A. niger complements PDI function in a S. cerevisiae pdi1 deletion mutant.; Function: pdiA from A. niger encodes a putative protein disulphide isomerase.; Gene-ID: pdiA;pdi1; Remark: a synonym for pdiA from A. niger is pdi1.; Remark: the transcription of pdiA from A. niger is induced 3-4-fold after treatment with tunicamycin, an inhibitor of N-linked glycosylation.; See PMID 9021130; See PMID 10653750
An02g14810	Function: Aut4 from S. cerevisiae is essential for the disintegration of autophagic vesicles, inside the vacuole of cells.; Localization: a biologically active fusion protein of Aut4 from S. cerevisiae and the green fluorescent protein is visualized at the vacuolar membrane and in punctate structures attached to the vacuole.; Remark: Aut4 from S. cerevisiae is a putative integral membrane protein with limited homologies to permeases.; Title: strong similarity to protein involved in autophagic vesicle breakdown Aut4 - Saccharomyces cerevisiae; See PMID 1105808
An02g14820	Complex: RGR1 interacts with SIN4 to organize chromatin structure and thus regulate transcription.; Function: RGR1 is required to repress the expression of glucose-regulated genes.; Title: strong similarity to regulator protein Rgr1 -Saccharomyces cerevisiae; nucleus; See PMID 7635307; See PMID 2196447
An02g14830	Catalytic activity: DPB2 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Function: DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in S. cerevisiae.; Phenotype: disruption of DPB2 is lethal.; Title: strong similarity to DNA polymerase II subunit-B Dpb2 - Saccharomyces cerevisiae; nucleus; See PMID 2052544
An02g14840	Title: similarity to protein sequence #9319 from patent WO200175067-A2 - Homo sapiens
An02g14850	Title: similarity to barley containing SNP protein fragment SEQ ID NO:660 from patent WO2003057877-A1 -Hordeum vulgare
An02g14860	Function: Antizyme protein binds to, and inhibits,ornithine decarboxylase ODC, a key enzyme in polyamine biosynthesis.; Remark: The matching EST is from Aspergillus niger deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to ornithine decarboxylase antizyme - Aspergillus nidulans; See PMID 10954585
An02g14870	Title: strong similarity to hypothetical conserved zinc-finger protein - Schizosaccharomyces pombe
An02g14880	Catalytic activity: dCMP + H2O = dUMP + NH3; Pathway: DCD1 plays a role in dTTP biosynthesis.; Phenotype: DCD1 mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate.; Title: strong similarity to dCMP deaminase Dcd1 -Saccharomyces cerevisiae; See PMID 6373725; See PMID 3023902
An02g14890	Function: HIS7 encodes a bifunctional glutamine amidotransferase: cyclase from S. cerevisiae.; Induction: HIS7 gene expression is regulated by the general control system of amino acid biosynthesis.; Pathway: HIS7 represents the first isolated eukaryotic gene encoding the enzymatic activities which catalyze the fifth and sixth step in histidine biosynthesis.; Title: strong similarity to amidotransferase/cyclase His7 - Saccharomyces cerevisiae; See PMID 8366040
An02g14900	Remark: C-terminally truncated due to contig border.; Remark: the C-terminal part of the gene is located on contig An02c0480.; Title: similarity to human peptidase HPEP-14 from patent WO200042201-A2 - Homo sapiens [truncated orf]
An02g14910	Remark: N-terminally truncated due to contig border.; Remark: the N-terminal part of the gene is located on contig An02c0460.; Title: similarity to human peptidase HPEP-14 from patent WO200042201-A2 - Homo sapiens [truncated orf]
An02g14920	Remark: ftsJ has been renamed rrmJ.; Remark: the methylation reaction catalyzed by ftsJ requires S-adenosylmethionine as donor of methyl groups.; Remark: the natural substrate for ftsJ are ribosomes or a pre-ribosomal ribonucleoprotein particle.; Title: strong similarity to 23S rRNA methyltransferase ftsJ - Escherichia coli; See PMID 10748051
An02g14930	Complex: OST3 corresponds to the 34-kD gamma-subunit of the yeast oligosaccharyltransferase.; Phenotype: expression of OST3 is not essential for viability, however its loss is accompanied by significant underglycosylation of soluble and membrane-bound glycoproteins in vivo.; Remark: within the lumen of the rough endoplasmic reticulum, oligosaccharyltransferase catalyzes the en bloc transfer of a high mannose oligosaccharide moiety from the lipid-linked oligosaccharide donor to asparagine acceptor sites in nascent polypeptides.; Title: strong similarity to dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain Ost3 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7622558
An02g14940	Title: strong similarity to human transmembrane protein HTMPN-23 from patent WO9961471-A2 - Homo sapiens
An02g14950	Function: CA3 is required for efficient pre-rRNA processing predominantly at site A3.; Localization: CA3 is localized predominantly in the nucleolus.; Phenotype: genetic depletion of CA3 results in a deficiency of 60S ribosomal subunits and a delayed synthesis of the mature 25S rRNA.; Remark: Dbp3p and CA3 are synonymous.; Remark: in S. cerevisiae, ribosomal biogenesis takes place primarily in the nucleolus, in which a single 35S precursor rRNA (pre-rRNA) is first transcribed and sequentially processed into 25S, 5. 8S, and 18S mature rRNAs, leading to the formation of the 40S and 60S ribosomal subunits.; Title: strong similarity to ATP-dependent RNA helicase Ca3 - Saccharomyces cerevisiae; nucleus; See PMID 9032262
An02g14960	Remark: blastP similarities are solely due to a 60 bp T repeat.
An02g14970	Function: mycocerosic acid synthase (MAS) is a multifunctional protein which catalyzes elongation of n-fatty acyl-CoA with methylmalonyl-CoA as the elongating agent.; Remark: mycocerosyl lipids are found uniquely in the cell walls of pathogenic mycobacteria.; Similarity: MAS is the first case of an elongating multifunctional enzyme composed of two identical subunits that resemble the vertebrate fatty acid synthase in size,subunit structure, and linear organization of functional domains.; Title: similarity to mycocerosate synthase MAS -Mycobacterium tuberculosis; See PMID 1527058
An02g14980	Catalytic activity: the SpSSB complex is active in single-stranded DNA binding and the T antigen-dependent unwinding of SV40 ori DNA.; Complex: ssb1(+) is a constituent of the heterotrimeric single-stranded DNA-binding protein complex SpSSB.; Title: strong similarity to single-stranded DNA-binding protein 68k chain ssb1p - Schizosaccharomyces pombe; See PMID 8702843
An02g14990	Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Function: UBP1 cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.; Remark: a splice site was detected upstream of the START codon.; Similarity: UBP1 belongs to family 2 of ubiquitin carboxyl-terminal hydrolases.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase UBP1 - Homo sapiens; See PMID 7851534
An02g15000	Remark: C-terminally truncated due to contig border.
An07g00010	Title: similarity to hypothetical protein encoded by An07g00070 - Aspergillus niger
An07g00020	Title: strong similarity to hypothetical protein Z -Streptomyces hygroscopicus
An07g00030	Remark: the ORF shows also strong similarity to proteins with (putative) other functions, such as oxidoreductases and aldo-keto-reductases.; Remark: the potassium channel beta subunit of B. taurus belongs to the fission yeast pyridoxine 4-dehydrogenase superfamily.; Remark: the potassium channel beta subunit of B. taurus shows alpha-dendrotoxin-sensitivity.; Title: strong similarity to oligosaccharyl transferase subunit - Bos taurus; See PMID 8127858; See PMID 8807399
An07g00040	Catalytic activity: fcs of Amycolatopsis sp. facilitates the ATP-dependent conversion of ferulic acid to feruloyl-Coenzyme A.; Pathway: the fcs protein of Amycolatopsis sp. participates in the bioconversion of ferulic acid to vanillin.; Remark: ferulic acid is a phenolic compound.; Similarity: the ORF shows similarity to several acid--CoA ligases from different species.; Title: strong similarity to feruloyl-CoA synthase -Amycolatopsis sp.; See PMID 11152072
An07g00050	Similarity: the ORF shows local similarity to ACEII of H. jecorina concerning the zinc-finger region necessary for DNA-binding.; Title: similarity to hypothetical transcription factor ACEII - Hypocrea jecorina
An07g00060	Function: the bmr3 transporter of B. subtilis functions as a multidrug transporter: it mediates resistance to puromycin, tosufloxacin, and norfloxacin.; Induction: expression of bmr3 is dependent on the growth phase of B. subtilis.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234
An07g00070	Title: strong similarity to hypothetical protein encoded by An07g00010 - Aspergillus niger
An07g00080	Pathway: the avnA protein of A. parasiticus is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway.; Phenotype: disruption of the avnA gene of A. parasiticus halts the aflatoxin production.; Remark: Aflatoxins are synthesized by condensation of acetate units.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Remark: avnA of A. parasiticus encodes a cytochrome P-450-type monooxygenase belonging to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431
An07g00090	Similarity: the ORF and the ren71 gene of S. aureofaciens show N-terminal similarity (up to amino acid 278 of the ORF). The aligned sequences include many gaps.; Title: similarity to hypothetical meta-cleavage compound hydrolase gene ren71 - Streptomyces aureofaciens
An07g00100	Catalytic activity: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.; Pathway: styrene degradation; arginine and proline metabolism; phenylalanine metabolism; tryptophan metabolism; cyanoamino acid metabolism.; Remark: the amidase from Rhodococcus sp. is an apparent homodimer, each molecule of which has an Mr of 48,554; it has a specific activity of 16. 5 mumol of S(+)-2-phenylpropionic acid formed per min per mg of enzyme from the racemic amide under our conditions.; Similarity: belongs to indoleacetamide hydrolase family.; Title: strong similarity to enantiomer-selective amidase amdA - Rhodococcus sp.; See PMID 1938876
An07g00110	Catalytic activity: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate.; Remark: Flavobacterium sp. KI72 metabolizes 6-aminohexanoic acid cyclic dimer, a by-product of nylon manufacture, through two evolved enzymes, 6-aminohexanoic acid cyclic dimer hydrolase (EI) and 6-aminohexanoic acid linear oligomer hydrolase (EII).; Title: strong similarity to 6-aminohexanoate-dimer hydrolase EII nylB - Flavobacterium sp.; See PMID 2512123; See PMID 6646204; See PMID 1879421
An07g00120	Title: questionable ORF
An07g00130	Similarity: belongs to the Escherichia coli ribosomal-protein-alanine N-acetyltransferase rimJ family.; Title: similarity to hypothetical conserved protein ynaD - Bacillus subtilis
An07g00150	Remark: bmr3 gene expression was dependent on the growth phase.; Remark: strong similarity to Aspergillus niger cDNA clone 3646 5', mRNA sequence.; Similarity: belongs to the multidrug-efflux transporter family.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234
An07g00160	Remark: mikimopine synthase and cucumopine synthase from Agrobacterium rhizogenes produced by a protein expression system using E. coli catalyzed the synthesis of mikimopine and cucumopine from L-histidine and alpha-ketoglutaric acid, requiring NADH as a cofactor.; Title: similarity to cucumopine synthase cus -Agrobacterium rhizogenes; See PMID 11223242
An07g00180	Title: questionable ORF
An07g00190	Title: similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides
An07g00200	Remark: EstC Burkholderia gladioli was able to hydrolyze a variety of esterase substrates of low to medium carbonic acid chain length, but no triglycerides were hydrolyzed.; Title: similarity to esterase EstC - Burkholderia gladioli; See PMID 11152069
An07g00220	Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An07g00230	Function: high affinity glucose transporter.; Localization: integral membrane protein.; Remark: disruption strains of HGT1 Kluyveromyces lactis showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An07g00240	Catalytic activity: hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Remark: RamA of Clostridium stercorarium hydrolysed p-nitrophenyl-alpha-L-rhamnopyranoside, naringin and hesperidin with a specific activity of 82, 1. 5 and 0. 46 U mg-1 respectively. Hydrolysis occurs by inversion of the anomeric configuration as detected using 1H-NMR, indicating a single displacement mechanism. Naringin was hydrolysed to rhamnose and prunin, which could further be degraded by incubation with a thermostable beta-glucosidase.; Title: strong similarity to alfa-L-rhamnosidase ramA - Clostridium stercorarium; See PMID 10632887
An07g00250	Remark: putative ataxanthin synthetase.; Remark: strong similarity to astaxanthin synthetase from patent EP1035206-A/2 - Phaffia rhodozyma.; Title: strong similarity to astaxanthin synthetase from patent EP1035206-A - Phaffia rhodozyma; See PMID 11341317
An07g00260	Title: strong similarity to hypothetical conserved protein CC0299 - Caulobacter crescentus
An07g00270	Remark: the encoded protein shows also similarities to the C-terminus of An07g01660.; Title: similarity to hypothetical protein EAA59869.1 - Aspergillus nidulans
An07g00280	Title: strong similarity to hypothetical host-specific AK-toxin Akt2 - Neurospora crassa
An07g00290	Catalytic activity: 3-cis-Dodecenoyl-CoA = 2-trans-Dodecenoyl-CoA.; Pathway: fatty acid metabolism.; Remark: ECI1 S. cerevisiae encodes a Delta3-cis-Delta2-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids.; Remark: alternative names YLR284c, EHD1.; Similarity: belongs to the enoyl-CoA hydratase/isomerase.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046; See PMID 9837886
An07g00300	Function: probable efflux transporter. confers resistance to the azole derivative fluconazole (fcz).; Remark: FLR1 gene encodes a plasma membrane transporter of the major facilitator superfamily (MFS) conferring resistance to multiple drugs, in particular to benomyl.; Similarity: belongs to the benomyl/methotrexate resistance proteins.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; See PMID 11162502
An07g00310	Remark: BAT1 from rats exhibited a Na(+)-independent transport of cystine as well as basic and neutral amino acids with the properties of system b(0,+).; Similarity: belongs to the amino acid transporters.; Title: similarity to amino acid transporter BAT1 -Rattus norvegicus; See PMID 10506124
An07g00320	Remark: expression induced by plant cell-wall proteins is controlled by both carbon and nitrogen catabolite repression. Glucose on its own represses acp1 expression while ammonium repression requires the simultaneous presence of a carbon source.; Title: strong similarity to non-aspartyl acid protease acp1 - Sclerotinia sclerotiorum; extracellular/secretion proteins; See PMID 11238979
An07g00330	Remark: alternate name in S. cerevisiae = YHR211W.; Title: weak similarity to flocculation protein Flo5 - Saccharomyces cerevisiae
An07g00350	Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism.; Remark: alpha-glucosidase II from Bacillus thermoamyloliquefaciens make each subunit of 3 secondary structural regions, i. e., one N-terminal beta region, one central alpha/beta region with two catalytic residues Asp407 and Asp484, and one C-terminal beta region.; Similarity: belongs to the alpha-glucosidases.; Title: similarity to alpha-glucosidase - Bacillus thermoamyloliquefaciens; See PMID 10945254
An07g00360	Remark: TPO1 encodes a polyamine transport protein on the vacuolar membrane in yeast. TPO1 and TPO4 recognized specificaly spermidine and spermine.; Remark: alternative name is YLL028W.; Similarity: belongs to the family of the major facilitator superfamily (MFS-MDR).; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11171066
An07g00370	Remark: DAL4 has similarity to the uracil permease component encoded by FUR4.; Remark: alternative name is YIR028w.; Similarity: belongs to the uracil/allantoin permase family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; See PMID 1293888
An07g00380	Remark: Hydantoinase is an enzyme for transforming 5-substd. hydantoin.; Remark: strong similarity to hydantoinase patent JP03251176-A - Pseudomonas NS 671.; Title: strong similarity to hydantoinase from patent JP03251176-A - Pseudomonas sp.; See PMID 1732229
An07g00390	Title: similarity to hypothetical protein BH1883 -Bacillus halodurans
An07g00400	Similarity: belongs to the short-chain alcohol dehydrogenase family.; Title: strong similarity to protein from patent WO0065067-A - Homo sapiens
An07g00420	Remark: only the N-terminal first 100 amino acids are matching.; Title: weak similarity to protein fragment SEQ ID NO:58643 from patent EP1033405-A2 - Arabidopsis thaliana
An07g00440	Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: LIP2 from Candida albicans is only expressed in media lacking lipids.; Similarity: belongs to the lipase family from Candida albicans.; Title: strong similarity to secretory lipase LIP2 -Candida albicans; See PMID 11131027
An07g00450	Catalytic activity: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2.; Pathway: pentose phosphate cycle.; Remark: also strong similarity to glucose oxidase GO2 from Aspergillus niger.; Remark: glucose oxidase from P. amagasakiense shows a high degree of identity (66%) and 79% similarity to glucose oxidase from Aspergillus niger, and is a member of the glucose-methanol-choline (GMC) oxidoreductase family. The overall structure can be divided into five distinct sequence regions: FAD-binding domain, extended FAD-binding domain, flavin attachment loop and intermediate region, FAD covering lid, and substrate-binding domain.; Similarity: belongs to the GMC oxidoreductase family.; Title: strong similarity to glucose oxidase GOX -Penicillium amagasakiense; See PMID 9523716
An07g00470	Catalytic activity: preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues.; Remark: Aspergillus fumigatus produces an 82 kDa intracellular metalloproteinase that hydrolyses the Pz-peptide,4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Ar g, a typical substrate of members of the thimet oligopeptidase family which is ubiquitously distributed across animal species.; Similarity: belongs to the Zn-dependent oligopeptidases.; Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; See PMID 9245813
An07g00480	Title: weak similarity to appressorium formation protein CAD2 - Colletotrichum lagenarium
An07g00510	Remark: the similarity is only found in the N-terminal half of the homolog portein.; Title: similarity to hypothetical lipoprotein SC4A2.13c - Streptomyces coelicolor
An07g00520	Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Remark: glutathione s-transferases are a group of enzymes of broad specificity. R may be an aliphatic,aromatic or heterocyclic group. X may be a sulfate, nitrite or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione; the reduction of polyol nitrate by glutathione to polyol and nitrite; certain isomerization reactions and disulfide interchange.; Remark: the A. thaliana enzyme is soluble and constitutively expressed in vegetative rosettes, but is under developmental control during the transition to bolting and flowering.; Similarity: belongs to the glutathione transferase.; Title: strong similarity to glutathione transferase GTH5 - Arabidopsis thaliana; See PMID 8375395
An07g00530	Remark: The ability to detoxify pisatin, a phytoalexin produced by garden pea (Pisum sativum), is controlled by a family of PDA (pisatin demethylating ability) genes in the phytopathogenic fungus Nectria haematococa, MP (mating population) VI.; Similarity: belongs to the cytochrome P450 family proteins.; Title: strong similarity to pisatin demethylase PDA6-1 - Nectria haematococca; See PMID 8076822
An07g00540	Title: similarity to hypothetical nucleoside-diphosphate-sugar epimerase AAM31397.1 -Methanosarcina mazei
An07g00550	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism; nitorobenzene degradation.; Remark: gene nahG of naphthalene/salicylate catabolic plasmid NAH7 encodes a protein of molecular weight 45,000, salicylate hydroxylase. This enzyme catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the 2-octaprenyl-6-metoxyphenol hydroxylase and related FAD-dependent oxidoreductases.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 2363715; See PMID 1993181
An07g00570	Remark: for Pth11 from M. grisea it is suggested that it functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: only the N-terminal half of PTH11 is matching this ORF. The ORF is about 200 amino acids shorter.; Remark: related to unknown integral membrane protein pth11 - Neurospora crassa with approximately the same lenght.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An07g00580	Remark: similarity to Bacillus subtilis serine protease SP1 (YUXL) patent WO9903984-A2.; Title: similarity to serine protease SP1 from patent WO9903984-A2 - Bacillus subtilis
An07g00590	Remark: the Japanese pear pathotype of Alternaria alternata produces host-specific AK-toxin and causes black spot of Japanese pear.; Title: strong similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 - Alternaria alternata; See PMID 10432635; See PMID 10975654
An07g00600	Remark: the encoded protein shows also similarities to the N-terminus of An11g03950.; Title: strong similarity to hypothetical protein EAA59869.1 - Aspergillus nidulans
An07g00620	Remark: the PPR1 gene of S. cerevisiae controls the transcription of two unlinked structural genes URA1 and URA3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 6096561; See PMID 6096562
An07g00630	Remark: YLL057c is involved in sulphonate catabolism. Purified recombinant yeast protein is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase.; Title: similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942
An07g00640	Remark: only the threonin and serin rich region is matching.; Title: weak similarity to hypothetical protein YDL037c - Saccharomyces cerevisiae
An07g00670	Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634
An07g00680	Catalytic activity: L-threonine = glycine + acetaldehyde.; Pathway: glycine, serine and threonine metabolism.; Remark: strong similarity to Pseudomonas putida threonine aldolase patent JP03277282-A.; Remark: the enzyme, requiring pyridoxal 5'-phosphate as a coenzyme, is strictly L specific at the alpha position, whereas it cannot distinguish between threo and erythro forms at the beta position. In addition to threonine, the enzyme also acts on various other L-beta-hydroxy-alpha-amino acids, including L-beta-3,4-dihydroxyphenylserine, L-beta-3,4-methylenedioxyphenylserine, and L-beta-phenylserine.; Similarity: belongs to the threonine aldolase family.; Title: strong similarity to low specificity L-threonine aldolase from patent JP03277282-A - Pseudomonas putida; See PMID 9464392
An07g00700	Remark: the ORF functions putative as dioxygenase.; Title: similarity to sequence SEQ ID NO:1465 from patent WO200294867-A2 - Photorhabdus luminescens
An07g00720	Remark: only a small domain is matching.; Title: weak similarity to activating transcription factor 2 ATF2 - Xenopus laevis
An07g00730	Similarity: to dehydrogenases with different specificities.; Title: similarity to hypothetical beta-hydroxybutyrate dehydrogenase hbdh1 - Ralstonia eutropha
An07g00750	Remark: inactivation of the amdR A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021
An07g00760	Remark: strong similarity to formyl-CoA transferase of Oxalobacter formigenes patent WO9816632-A1.; Remark: the Oxalobacter enzyme, together with oxalyl-CoA decarboxylase (V34839), converts oxalate to carbon dioxide and formate (in presence of oxalyl-coenzyme A). O. formigenes is an oxalate-dependent obligate anaerobic symbiont, present in the intestines of vertebrates, and involved in regulation of oxalic acid absorption.; Similarity: to predicted acyl-CoA transferases/carnitine dehydratases.; Title: strong similarity to formyl-CoA transferase from patent WO9816632-A1 - Oxalobacter formigenes; See PMID 8125343
An07g00780	Remark: human MCT2 mRNA expression was restricted in normal human tissues but widely expressed in cancer cell lines, suggesting that MCT2 may be pre-translationally regulated in neoplasia.; Remark: the transport of pyruvate and lactate across cellular membranes is an essential process in mammalian cells and is mediated by the H+/monocarboxylate transporters (MCTs).; Remark: the unique biochemical feature of human MCT2 is its high affinity for the transport of pyruvate (apparent Km of 25 microM), implying that it is a primary pyruvate transporter in man.; Title: strong similarity to monocarboxylate transporter 2 hMCT2 - Homo sapiens; See PMID 9425115; See PMID 9786900; See PMID 10510291
An07g00790	Remark: choline monooxygenase (CMO) catalyzes the committing step in the synthesis of glycine betaine, an osmoprotectant accumulated by many plants in response to salinity and drought.; Remark: strong similarity to Sugarbeet choline monooxygenase patent WO9830702-A2.; Similarity: belongs to the Rieske [2Fe-2S] protein family.; Title: strong similarity to choline monooxygenase from patent WO9830702-A2 - Beta vulgaris; See PMID 9489025
An07g00800	Catalytic activity: 2 geranylgeranyl diphosphate = pyrophosphate + prephytoene diphosphate.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: RNA measurements showed that the level of al-2 mRNA increased over 30-fold in photoinduced mycelia compared with dark-grown mycelia.; Title: strong similarity to geranylgeranyl diphosphate geranylgeranyltransferase al-2 - Neurospora crassa; See PMID 8163509
An07g00810	Remark: C-terminal truncated ORF due to end of contig.; Similarity: shows weak similarity to bacteriochlorophyll synthases.; Title: similarity to hypothetical protein B24P7.350 - Neurospora crassa [truncated ORF]
An07g00820	Function: xenA of P. putida removes central or terminal nitro-groups from nitroglycerin as nitrite.; Similarity: contains FMN oxidoreductase domain.; Similarity: shows much higher similarity to probable nadh-dependent flavin oxidoreductase of S. pombe.; Title: similarity to xenobiotic reductase A xenA -Pseudomonas putida; See PMID 10515912
An07g00830	Title: questionable ORF
An07g00840	Similarity: shows similarity to proteins containing Zn(2)-Cys(6) binuclear cluster.
An07g00860	Function: S. cerevisiae RTA1 gene is involved in 7-aminocholesterol resistance.; Remark: alternate names for RTA1 are protein G7811 and protein YGR213c.; Remark: seems to be a duplication of ORF440WK.; Similarity: shows strong similarity to hypothetical proteins of S. cerevisiae.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8660468
An07g00870	Remark: ORF might be questionable.
An07g00880	Localization: ankyrins are located in the cytoskeleton.; Remark: most of the ankyrins show alternative splicing.; Similarity: shows similarity to ankyrin domains of corresponding proteins.; Title: weak similarity to ankyrin 1 ANK1 - Homo sapiens
An07g00900	Title: similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum; See PMID 8624443
An07g00905	Title: similarity to hypothetical protein B8J22.030 - Neurospora crassa
An07g00930	Function: putative metallo-beta-lactamase because of corresponding pfam-domain.; Similarity: shows similarity to hydrolases including glyoxylases.; Similarity: shows strong similarity to several hypothetical proteins of different species.; Title: strong similarity to hypothetical protein PA2915 - Pseudomonas aeruginosa
An07g00940	Catalytic activity: converts thiosulfate + cyanide <=> sulfite + thiocyanate.; Function: transferring sulfur-containing groups.; Remark: alternative names are rhodanese, thiosulfate cyanide transsulfurase and thiosulfate thiotransferase.; Similarity: shows similarity to several thiosulfate sulfurtransferase, because of corresponding pfam-domain.; Title: strong similarity to hypothetical thiosulfate sulfurtransferase - Gallus gallus; See PMID 2275748
An07g00950	Catalytic activity: the C. albicans homolog CAA31962. 1 preferential cleaves at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; Repression: this C. albicans endopeptidase is inhibited by pepstatin, but not by methyl 2-diazoacetamido-hexanoate or 1,2-epoxy-3-(P-nitrophenoxy)propane.; Similarity: belongs to peptidase family A1.; Title: similarity to aspartyl proteinase candidapepsin - Candida albicans; See PMID 2646602
An07g00960	Remark: ORF might be questionable.
An07g00970	Function: S. cerevisiae RTA1 gene is involved in 7-aminocholesterol resistance.; Remark: alternate names for RTA1 are protein G7811 and protein YGR213c.; Remark: seems to be a duplication of ORF515WS.; Similarity: shows strong similarity to hypothetical proteins of S. cerevisiae.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8660468
An07g00980	Function: probable sugar (and other) transporter,contains corresponding pfam-domain.; Localization: probable membrane protein, contains 4 transmembranal regions.; Title: strong similarity to hypothetical membrane protein YIL166c - Saccharomyces cerevisiae
An07g01000	Function: In A. niger cultures which were shifted from growth on sucrose to growth on apple pectin as a carbon source, the expression of the rhamnogalacturonan hydrolase A gene (rhgA) was transiently induced after 3 h of growth on apple pectin.; Localization: might be located in the plasma membrane.; Remark: possible sequencing error around pos. 102865.; Similarity: There exist two rhamnogalacturonases in A. niger rhgA and rhgB, but the ORF is not identical to one of them.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus niger [putative sequencing error]; See PMID 9212401
An07g01010	Function: sulphamidase is an exoglycosidase involved in the degradation of heparan sulfate.; Remark: alternative names are N-sulphoglucosamine sulphohydrolase.; Title: strong similarity to sulphamidase - Mus musculus; extracellular/secretion proteins; See PMID 10818207
An07g01020	Remark: ORF might be questionable.
An07g01030	Function: FUM5 polyketide synthase gene is required for biosynthesis of fumonisin mycotoxins.; Similarity: shows strong similarity in the aminoterminus to FUM5, but lacks the carboxyterminal part.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 10802562; See PMID 10872449
An07g01040	Similarity: shows similarity to proteins containing phosphopantetheine attachment sites.; Title: weak similarity to polyketide synthase Fum5 -Gibberella moniliformis
An07g01050	Title: weak similarity to hypothetical protein encoded by An05g01720 - Aspergillus niger
An07g01060	Remark: possible functions for the CIH1 protein in the establishment and maintenance of biotrophy are discussed.; Title: similarity to CIH1 gene for intracellular hyphae protein 1 - Colletotrichum lindemuthianum; See PMID 9721685
An07g01080	Title: weak similarity to hypothetical DEAD-box RNA helicase SCH22A.10 - Streptomyces coelicolor
An07g01090	Remark: expression of C. albicans MDR1-3 in S. cerevisiae confers resistance to several unrelated drugs.; Title: strong similarity to multidrug resistance protein MDR1-3 - Candida albicans; plasma membrane; See PMID 9745021
An07g01100	Catalytic activity: glutathione S-transferase omega of S. scrofa catalyses the reaction RX + glutathione = HX + R-S-glutathione.; Localization: glutathione S-transferase omega of S. scrofa is cytosolic.; Similarity: the predicted A. niger protein shows similarity to glutathione S-transferase omega of S. scrofa,which belongs to the omega class [GSTO] of glutathione S-transferases.; Title: similarity to glutathione S-transferase omega - Sus scrofa; See PMID 11485575
An07g01110	Catalytic activity: random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.; Title: similarity to hyaluronan synthase 3 Has3 -Mus musculus; See PMID 9083017
An07g01130	Remark: Glomerella cingulata is also known as Glomerella rufomaculans-vaccinii[synonym] and Colletotrichum gloeosporioides[anamorph].; Remark: chip3 of Glomerella cingulata is induced by hard-surface contact of conidia of C. gloeosporioides.; Title: similarity to hypothetical hard surface induced protein chip3 - Glomerella cingulata; See PMID 10940006
An07g01150	Remark: acting on the CH-CH group of donors.; Similarity: protein shows also strong similarity to Phaffia rhodozyma carotenoid biosynthesis pathway enzyme PRcrtI from patent WO9723633-A1; Phaffia derived GAPDH and carotenoid synthesis genes are used in the recombinant production of therapeutically useful proteins e. g. carotenoids for use in food colouring.; Title: strong similarity to phytoene dehydrogenase PDH1 - Cercospora nicotianae; See PMID 8085820
An07g01160	Function: CRH2 of S. cerevisiae expression did not vary during the mitotic cycle.; Function: two genes, CRH1 and CRH2 of S. cerevisiae,were shown to be involved in the development of cell wall architecture, since the alkali-soluble glucan fraction in a crh1Delta crh2Delta strain was almost twice the level in the wild-type.; Localization: Crh2 of S. cerevisiae was localized at the cell surface, particularly in chitin-rich areas.; Localization: Crh2p of S. cerevisiae was found to localize mainly at the bud neck throughout the whole budding cycle, in mating projections and zygotes, but not in ascospores.; Remark: alternate genename of UTR2 of S. cerevisiae is CHR2, the systematic gene name is YEL040w.; Title: strong similarity to cell wall protein Utr2 -Saccharomyces cerevisiae; cell wall; See PMID 10757808
An07g01190	Title: weak similarity to hypothetical protein encoded by An07g03100 - Aspergillus niger
An07g01200	Function: LovC of A. terreus is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L during lovastatin biosynthesis.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities and cellular functions.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; See PMID 11457314
An07g01220	Function: might be involved in transport of antibiotics.; Function: possibly involved in modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.; Function: shows pfam-domain common in sugar (and other) transporter.; Localization: shows several transmembrane domains.; Similarity: ORF10 of A. terreus is similar to efflux pumps and resistance proteins of different species.; Title: strong similarity to hypothetical protein encoded by ORF10 - Aspergillus terreus
An07g01230	Function: suc uptake in D. carota was inhibited by protonophores, suggesting that Suc transport is linked to the proton electrochemical potential across the plasma membrane.; Similarity: shows higher similarity to probable sucrose carrier of S. pombe.; Title: similarity to source- and sink-specific sucrose/H+ symporters - Daucus carota; plasma membrane; See PMID 9847123
An07g01240	Remark: ORF might be questionable.
An07g01250	Remark: the transcription of atrA in mycelium of A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Similarity: the protein shows also strong similarity to yeast transporter Pdr5p (PATENTPROT: AAB28182,patentno. WO200052144-A1).; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695
An07g01260	Function: contains domain common in sugar transport proteins.; Similarity: shows strong similarity to several sugar transport proteins (including hypothetical and patented).; Title: strong similarity to hypothetical sugar transport-like protein Stl1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8076821
An07g01270	Title: strong similarity to hypothetical protein EAK86332.1 - Ustilago maydis
An07g01280	Remark: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae, as it is in A. nidulans.; Title: similarity to transcription regulator AmdR -Aspergillus oryzae; See PMID 145202
An07g01290	Catalytic activity: xylitol + NAD(+) <=> D-xylulose + NADH.; Remark: also acts as an L-erythrulose reductase.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 9806889; See PMID 10661867
An07g01310	Function: high affinity glucose transporter.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679
An07g01320	Function: the P. chrysogenum paf gene encodes an abundantly secreted protein with antifungal activity.; Title: strong similarity to antifungal protein precursor paf - Penicillium chrysogenum
An07g01340	Title: weak similarity to phosphoenolpyruvate carboxylase - Escherichia coli
An07g01350	Function: NahW of P. stutzeri is involved in naphthalene and salicylate metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An07g01360	Title: similarity to hypothetical protein CAD21381.1 - Neurospora crassa
An07g01380	Function: CMR1, a novel transcriptional activator with Cys2His2 type zinc-finger and Zn(II)2Cys6 binuclear cluster motifs regulates transcription of melanin biosynthesis genes SCD1 and THR1 during mycelial melanization of C. lagenarium.; Remark: submitted (MAR-1999) to the EMBL by Kubo Y.; Title: strong similarity to hypothetical transcriptional activator CMR1 - Colletotrichum lagenarium
An07g01390	Title: similarity to hypothetical conserved protein PA2839 - Pseudomonas aeruginosa
An07g01400	Catalytic activity: an aldehyde + NAD(P)(+)+H(2)O <=> an acid + NAD(P)H; Title: similarity to aldehyde dehydrogenase ALDH3 -Rattus norvegicus; See PMID 9095201; See PMID 2713359; See PMID 2831537
An07g01420	Induction: binA gene expression induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans; See PMID 10376827
An07g01430	Title: strong similarity to hypothetical protein Rv1215c - Mycobacterium tuberculosis
An07g01440	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Remark: the salicylate hydroxylase, a flavoprotein monooxygenase, catalyzes the decarboxylative hydroxylation of salicylate to form catechol.; Title: similarity to salicylate hydroxylase sal -Pseudomonas putida; See PMID 2916843; See PMID 8561793; See PMID 10920265
An07g01470	Title: strong similarity to hypothetical v-snare binding protein SPAC56F8.08 - Schizosaccharomyces pombe
An07g01480	Title: strong similarity to hypothetical protein EAA58558.1 - Aspergillus nidulans
An07g01510	Title: similarity to 2,4-dichlorophenoxyacetate monooxygenase tfdA - Alcaligenes eutrophus; See PMID 3036764
An07g01520	Complex: Nup170p of S. cerevisiae binds to the amino-terminal domain of Nup1p. Nup170p is a part of the nuclear pore complex.; Function: Nup170p and Nup188p are involved in establishing the functional resting diameter of the NPC's central transport channel.; Remark: YBL079w is the systematic name of NUP170 and YER105c is the systematic name of NUP157.; Remark: a deletion strain of NUP170 (nup170 Delta::HIS3) has a Ctf- (chromosome transmission fidelity) phenotype similar to the s141 mutant (nup170-141) and also exhibits a kinetochore integrity defect.; Similarity: the predicted A. niger protein shows strong similarity to nucleoporin Nup170p and Nup157p of S. cerevisiae and related proteins from higher eucaryotes.; Title: strong similarity to nucleoporin Nup170 -Saccharomyces cerevisiae; nucleus; See PMID 8628268; See PMID 10831607; See PMID 11290711
An07g01530	Title: weak similarity to hypothetical conserved protein VC0519 - Vibrio cholerae
An07g01540	Remark: BLASTp searches with yeast hypothetical protein YMR200w/Rot1p and Dna2p demonstrate, that Rot1p and Dna2p are not related as opposed to results described by Fiorentino and Crabtree (Mol Biol Cell 1997; 8(12):2519-37).; Remark: null mutant is inviable; rot1 mutations can suppress tor2 mutations; synthetically lethal with rot2.; Remark: reversal of tor2 lethality.; Similarity: the predicted A. niger protein shows strong similarity to yeast hypothetical protein YMR200w/Rot1p.; Title: strong similarity to hypothetical protein YMR200w - Saccharomyces cerevisiae; See PMID 9398673; See PMID 9545237
An07g01550	Catalytic activity: ATP + 5-formyltetrahydrofolate = ADP + orthophosphate + 5,10-methenyltetrahydrofolate.; Remark: This enzyme is involved in the regulation of the folate-dependent reactions of amino acid, purine and pyrimidine synthesis through modulation of intracellular 5-formyltetrahydrofolate polyglutamates.; Remark: the enzyme catalyses the obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates.; Title: similarity to 5-formyltetrahydrofolate cyclo-ligase MTHFS - Homo sapiens; See PMID 8522195
An07g01560	Remark: the human small nuclear ribonucleoprotein E protein is an integral component of several small nuclear ribonucleoprotein complexes involved in RNA processing reactions.; Remark: the snRNP E protein is one of four 'core' proteins associated with the snRNAs of the U family (U1, U2, U4, U5, and U6).; Title: strong similarity to small nuclear ribonucleoprotein E - Homo sapiens; nucleus; See PMID 2972723; See PMID 1835977
An07g01580	Remark: Mtr10p binds peptide repeat-containing nucleoporins and Ran.; Remark: Mtr10p is shown to be responsible for the nuclear import of the shuttling mRNA-binding protein Npl3p.; Title: strong similarity to nuclear import protein Mtr10 - Saccharomyces cerevisiae; See PMID 9412460
An07g01620	Remark: the gene contains two C2H2 zinc fingers, a nuclear localization sequence and two transcriptional activation domains. mutations in the amdA gene lead to elevated expression of the gene encoding acetamidase, amdS. these mutations also cause constitutive expression of the acetate-inducible gene, aciA.; Similarity: the predicted A. niger protein shows similarity to the DNA-binding protein amdA from A. nidulans and strong similarity to fungal hypothetical zinc finger proteins.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297; See PMID 9126617
An07g01640	Remark: among the enzymes to be stimulated by the calmodulin Ca(++) complex are protein kinases and phosphatases.; Remark: calmodulin has four functional calcium-binding sites and shows similarity to other EF-hand calcium binding proteins.; Remark: calmodulin mediates the control of a large number of enzymes by Ca(++).; Title: strong similarity to calmodulin 6 CaM6 -Arabidopsis thaliana; See PMID 8507825
An07g01650	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An07g01660	Title: weak similarity to hypothetical host-specific AK-toxin Akt2 like protein CAB91703.2 - Neurospora crassa
An07g01670	Remark: the Japanese pear pathotype of A. alternata causes black spot of Japanese pear by producing a host-specific toxin known as AK-toxin.; Remark: the essential roles of AKT1 and AKT2 in both AK-toxin production and pathogenicity were confirmed by transformation-mediated gene disruption experiments. AKT2 encodes a protein of unknown function.; Title: similarity to protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635; See PMID 10975654
An07g01680	Similarity: shows similarity to several known and hypothetical transcriptional activators, the similarity is restricted to the zinc finger domain.; Title: similarity to hypothetical transcription activator CAB59617.1 - Schizosaccharomyces pombe
An07g01690	Title: weak similarity to hypothetical protein CAC28841.2 - Neurospora crassa
An07g01700	Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa
An07g01710	Catalytic activity: myo-inositol 2-dehydrogenase (iolG) from B. subtilis catalyses the reaction myo-inositol + NAD(+)<=> 2,4,6/3,5-pentahydroxycyclohexanone + NADH.; Function: myo-inositol 2-dehydrogenase (iolG) from B. subtilis catalyses the first step in inositol catabolism to utilize myo-inositol as sole carbon/energy source.; Similarity: the ORF shows similarity to several unspecified NADH-dependent dyhydrogenases from bacteria.; Title: strong similarity to myo-inositol 2-dehydrogenase iolG - Bacillus subtilis; See PMID 9226270; See PMID 112095
An07g01720	Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae
An07g01730	Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein YJR154w of S. cerevisiae and to a hypothetical protein derived from P. aeruginosa pathogenicity island (PAGI-1).; Title: strong similarity to hypothetical protein YJR154w - Saccharomyces cerevisiae
An07g01740	Remark: the patent does not provide further information about the function of the protein.; Title: weak similarity to polypeptide sequence SEQ ID NO:3328 from patent WO200058473-A2 - Homo sapiens
An07g01750	Title: weak similarity to hypothetical protein B2O8.260 - Neurospora crassa
An07g01760	Title: questionable ORF
An07g01780	Title: weak similarity to hypothetical galactosyltransferase spdbp - Schizosaccharomyces pombe
An07g01820	Remark: truncated ORF due to end of contig.; Title: weak similarity to stationary phase induced protein Spi1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10641036; See PMID 11136466
An07g01830	Catalytic activity: scytalone + NADP(+) <-> 1,3,6,8-tetrahydroxynaphthalene + NADPH.; EC:1.1.1.256; Remark: tetrahydroxynaphthalene reductase is involved with EC 4. 2. 1. 94 in the biosynthesis of melanin in pathogenic fungi.; Title: strong similarity to 1,3,6,8-tetrahydroxynaphthalene reductase arp2 - Aspergillus fumigatus; See PMID 10515939; See PMID 8293526
An07g01850	Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An07g01860	Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Remark: the systematic name for CYB2 of S. cerevisiae is YML054C.; Title: weak similarity to L-lactate dehydrogenase precursor Cyb2 - Saccharomyces cerevisiae; See PMID 3004948
An07g01870	Catalytic activity: phenol + NADPH + O2 = catechol + NADP+ + H2O.; Remark: FAD is used as cofactor of phenol hydroxylase in Trichosporon cutaneum.; Remark: alternate name = phenol 2-monooxygenase.; Remark: phenol hydroxylases are involved in degradation of phenylalanine, toluene and gamma-hexachlorocyclohexane.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 9634698; See PMID 1429434
An07g01900	Protein sequence is in conflict with the conceptual translation; Catalytic activity: 3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2.; Remark: alternate name = TcrP (T-cell reactive protein).; Title: strong similarity to 4-hydroxyphenylpyruvate-dioxygenase tcrP - Coccidioides immitis [putative sequencing error]; putative sequencing error; See PMID 7642122
An07g01910	Protein sequence is in conflict with the conceptual translation; Title: strong similarity to hypothetical protein EAA58547.1 - Aspergillus nidulans [putative sequencing error]; putative sequencing error
An07g01930	Remark: the ankyrin gene from Mus musculus undergoes alternative splicing, resulting in 4 different splice variants.; Title: similarity to ankyrin 3 (splice form 3) - Mus musculus
An07g01940	Remark: putative frameshift due to possible sequencing error at position 9631.; Title: similarity to hypothetical amine transporter SPCC18.02 - Schizosaccharomyces pombe [putative frameshift]
An07g01950	Title: strong similarity to purine permease with broad specificity uapC - Aspergillus nidulans
An07g01960	Title: strong similarity to stearoyl-CoA desaturase P-ole1 - Pichia angusta
An07g01970	Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; cytoplasm
An07g01980	Title: questionable ORF
An07g01990	Function: rhp55p from S. pombe is involved in double-strand break repair.; Remark: the S. pombe rhp55Delta mutant Is highly sensitive to DNA damage.; Title: similarity to DNA repair protein rhp55p -Schizosaccharomyces pombe; See PMID 10430583; See PMID 11560889
An07g02000	Title: similarity to hypothetical protein encoded by An18g03630 - Aspergillus niger
An07g02010	Complex: Pre8 from S. cerevisiae is one of the subunits of the proteasome.; Function: Pre8 from S. cerevisiae is essential for growth.; Function: Pre8 from S. cerevisiae takes part in the ubiquitin dependend protein degradation.; Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Remark: the synonym for PRE8 from S. cerevisiae is YML092c.; Title: strong similarity to proteasome 20S subunit Pre8 - Saccharomyces cerevisiae; See PMID 9575337; See PMID 10744762
An07g02020	Title: similarity to hypothetical protein CAB91761.2 - Neurospora crassa
An07g02040	Title: weak similarity to hypothetical protein Tid3 - Saccharomyces cerevisiae
An07g02050	Catalytic activity: 2,3-dihydroxybenzoate <=> catechol + CO(2).; Function: 2,3-Dihydroxybenzoic acid decarboxylase is the last enzyme in the fungal metabolism of indole to catechol and catalyzes the non-oxidative decarboxylation of 2,3-dihydroxybenzoic acid to catechol.; Gene-ID: dhbD; See PMID 7601088
An07g02060	Title: similarity to myo-inositol transporter 2 -Schizosaccharomyces pombe; plasma membrane; See PMID 9560432
An07g02070	Title: weak similarity to hypothetical protein SC8D9.09 SC8D9.09 - Streptomyces coelicolor
An07g02080	Function: The mitochondrial outer membrane enzyme kynurenine 3-hydroxylase (K3H) is an NADPH-dependent flavin mono-oxygenase involved in the tryptophan pathway, where it catalyzes the hydroxylation of kynurenine.; Title: similarity to kynurenine3-hydroxylase hK3OH-2 - Homo sapiens; localisation:mitochondrion; See PMID 10672018; See PMID 6468727
An07g02090	Title: weak similarity to hypothetical chloroplast RNA-binding protein At2g35410 - Arabidopsis thaliana
An07g02100	Catalytic activity: fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + orthophosphate.; Function: The S. cerevisiae fructose-2,6-bisphosphate 2-phosphatase FBP26 is a bifunctional enzyme with catalytic activities of EC 2. 7. 1. 105 and predominantely EC 3. 1. 3. 46.; Title: strong similarity to fructose-2,6-bisphosphate 2-phosphatase Fbp26 - Saccharomyces cerevisiae; cytoplasm; See PMID 9032446; See PMID 1322693
An07g02110	EC:3.4.16.1; Function: CPY releases a C-terminal amino acid with a broad specificity.; Function: the S. cerevisiae homolog CPY bears the major proteolytic activity in the yeast vacuole. it is synthesized as a precursor that is processed upon entry into the vacuolar lumen. mature CPY processes CPY precursor as well as other vacuolar protease precursors.; Remark: a deletion of CPY leads to complete loss of vacuolar proteolytic activity within days of growth due to slowly decreasing processing of other vacuolar protease precursors.; Remark: similarity corresponds only to the C-terminus.; Remark: the CPY vacuolar targeting signal is defined by four propeptide amino acids.; Similarity: CPY belongs to serine carboxypeptidase family S10.; Title: similarity to vacuolar carboxypeptidase Y Cpy - Saccharomyces cerevisiae; vacuole; See PMID 9111041
An07g02120	Title: weak similarity to hypothetical protein YJL184w - Saccharomyces cerevisiae
An07g02130	Title: strong similarity to hypothetical protein CAD21228.1 - Neurospora crassa
An07g02140	Title: weak similarity to hypothetical endogenous retrovirus W envelope protein - Homo sapiens
An07g02150	Title: similarity to hypothetical AAA family ATPase Cj0377 - Campylobacter jejuni
An07g02160	Catalytic activity: (S)-malate + NAD(+) = oxaloacetate + NADH.; Title: strong similarity to mitochondrial malate dehydrogenase Mdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3072021; See PMID 3312168; See PMID 1447211
An07g02170	Function: Bos1 of S. cerevisiae appears to be a membrane protein that functions in conjunction with Bet1 and Sec22 to facilitate the transport of proteins at a step subsequent to translocation into the ER but before entry into the Golgi apparatus.; Title: similarity to transport protein Bos1 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 1396561; See PMID 2007627; See PMID 2192256
An07g02180	Catalytic activity: acetyl-CoA + dihydrolipoamide <=> CoA + S-acetyldihydrolipoamide.; Function: the s. cerevisiae dihydrolipoamide acetyltransferase is a component (E2) of the mitochondrial pyruvate dehydrogenase complex.; Remark: the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa & co(2).; Remark: the pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) & lipoamide dehydrogenase (e3).; Title: strong similarity to dihydrolipoamide acetyltransferase Lat1 - Saccharomyces cerevisiae; localisation:mitochondrion
An07g02190	Function: the Sec7 protein of S. cerevisiae may function as a peripheral membrane protein that cycles between a soluble, cytosolic pool and a sedimentable,membrane-associated complex for its essential role in vesicular traffic through the Golgi apparatus.; Title: strong similarity to protein Sec7 -Saccharomyces cerevisiae; cytoplasm; See PMID 3042778; See PMID 1986005
An07g02200	Catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin.; Title: similarity to siroheme synthase cysG -Escherichia coli; See PMID 2407558; See PMID 2200672
An07g02210	Catalytic activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Function: the S. cerevisiae PRPS1 is a rate-limiting enzyme in the biosynthesis of nucleotides, histidine, and tryptophan. disruption of this gene causes the most dramatic decrease in cell growth rate and enzyme activity.; Remark: disruption of the other ribose-phosphate pyrophosphokinases in S. cerevisiae (PRS2 or PRS4) has little measurable effect.; Remark: the S. cerevisiae genome contains a family of five ribose-phosphate pyrophosphokinase genes,PRS1-PRS5.; Similarity: the predicted A. niger protein shows strong similarity to ribose-phosphate pyrophosphokinase 1 (PRPS1) from S. cerevisiae and from many other organisms.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prps1 - Saccharomyces cerevisiae; See PMID 7992503; See PMID 8007970; See PMID 9108276; See PMID 11101685
An07g02240	Alternative name: SPO14; Catalytic activity: a phosphatidylcholine + H(2)O = choline + a phosphatidate.; Function: the PLD1 protein of S. pombe is required for meiosis and spore formation and seems to be involved in the coordinate induction of late meiotic events.; Remark: activity of S. pombe Pld1 is dependent of phosphatidylinositol 4,5-bisphosphate.; Remark: activity of S. pombe Pld1 is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth.; Similarity: similarities corresponds only to the C-terminus, Blastx results showed no similarities for N-terminus.; Title: strong similarity to phospholipase Pld1 -Saccharomyces cerevisiae; See PMID 8576189; See PMID 8618862; See PMID 1582554
An07g02250	Title: strong similarity to hypothetical DNA methylase SPAC27D7.08c - Schizosaccharomyces pombe
An07g02260	Protein sequence is in conflict with the conceptual translation; Remark: 5'-truncated ORF due to end of contig.; Remark: putative frameshift due to possible sequencing error at position 864.; Similarity: similarity to S. pombe gene SPAC4F10. 21 probably extends over the contig border.; Title: strong similarity to hypothetical protein SPAC4F10.21 - Schizosaccharomyces pombe [truncated ORF] [putative frameshift]; putative frameshift
An07g02270	Function: mbp1 binds to mcb elements (mlu1 cell cycle box) found in the promoter of most dna synthesis genes.; Function: the transcriptional activation by mbp1 has an important role in the transition from G1 to S phase.; Remark: C-terminally truncated ORF due to contig border.; Remark: it is supposed that the predicted ORF is 300 amino acids shorter at its C-terminus due to the end of the contig.; Similarity: the predicted ORF shows similarity with mbp1 of several spezies, but is 100 amino acids longer at its N-terminal end.; Title: strong similarity to transcription factor Mbp1 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 8372350
An07g02280	Title: questionable ORF
An07g02290	Function: calcineurin is a calcium-dependent,calmodulin stimulated protein phoshatase.; Similarity: the predicted ORF shows weak similarity to the regulatory subunit of calcineurin from several spezies, but the predicted protein probably lacks at least one of the four calcium-binding sites.; Title: strong similarity to hypothetical protein CAE76397.1 - Neurospora crassa
An07g02300	Complex: rsc8 is the eighth largest subunit of RSC,a fifteen-protein chromatin remodeling complex and related to the Swi/snf Complex.; Function: rsc8 as a component of the chromatin remodeling complex RSC is supposed to enable chromatin remodeling for transcriptional regulation of genes.; Remark: rsc8 of S. cerevisiae is also called SWH3 or YFR037C.; Title: strong similarity to chromatin remodeling gene transcription regulator Rsc8 - Saccharomyces cerevisiae; nucleus; See PMID 9121424
An07g02310	Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Function: the function of glutathione S-transferases (GST) is the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and the isoenzymes appear to play a central role in the parasite detoxification system.; Remark: the predicted ORF overlaps with EST BE759905 of A. niger.; Similarity: the predicted ORF shows similarity to some glutathione S-transferases from several spezies.; Title: strong similarity to glutathione transferase D27 - Drosophila melanogaster
An07g02320	Title: questionable ORF
An07g02350	Similarity: the similarity to the myb-like protein of S. pompe is restricted to the inner domain of the predicted ORF, reaching from amino acid 115 to 480, for which a DNA-binding domain of the SANT type is predicted.; Title: similarity to hypothetical myb-like DNA-binding - Schizosaccharomyces pombe; See PMID 8882580
An07g02360	Catalytic activity: 6-hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Function: A. oxidans 6-HDNO is involved in nicotine-acetyl-CoA catabolism.; Remark: the N-terminal region from amino acid 1 to 230 of the predicted ORF shows strong similarity to several FAD-binding domain containing proteins.; Remark: the group of FAD-binding domain proteins consists of various enzymes that use FAD as a co-factor,most of the enzymes are similar to oxygen oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans
An07g02370	Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Remark: the predicted ORF shows similarities to an integral membrane protein of M. grisea in its N-terminal region including amino acid 10 to 280.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An07g02380	Function: TRI7 of F. sporotrichioides is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: weak similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533
An07g02400	Title: similarity to hypothetical protein encoded by An18g00950 - Aspergillus niger
An07g02410	Title: weak similarity to hypothetical protein encoded by An14g05600 - Aspergillus niger
An07g02420	Remark: blastp matches are unspecific.
An07g02440	Catalytic activity: rat microsomal carboxylesterase catalyzes the reaction of a carboxylic ester + H2O = an alcohol + a carboxylic anion.; Function: rat microsomal carboxylesterase is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. hydrolyzes omicron-nitrophenyl acetate and alpha-naphthyl acetate. it also hydrolyzes acetanilide and, distinctively,palmitoyl-Coa.; Remark: liver carboxylesterase 4, carboxyesterase ES-4 and microsomal palmitoyl-CoA hydrolase are alternative names for kidney microsomal carboxylesterase.; Similarity: belongs to the type-B carboxylesterase/lipase family.; Title: similarity to kidney microsomal carboxylesterase - Rattus norvegicus; See PMID 7961958; See PMID 8611161
An07g02450	Remark: the ORF encoded protein is C-terminally truncated due to the end of contig.
An07g02500	Title: weak similarity to protein fragment SEQ ID NO:44609 from patent EP1033405-A2 - Arabidopsis thaliana
An07g02510	Remark: blastp matches are unspecific.; Title: strong similarity to hypothetical protein encoded by An08g12110 - Aspergillus niger
An07g02530	Phenotype: yeast bst1 mutants how enhanced leaking from the ER of the ER resident proteins Kar2p and Pdi1p.; Phenotype: yeast bst1 mutants show reduced secretion of some secretory proteins.; Remark: YFL025c is the systematic name for yeast BST1.; Title: similarity to negative regulator of COPII vesicle formation Bst1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 11208122; See PMID 8862519
An07g02540	Function: JEN1 of S. cerevisiae is a lactate and pyruvate proton-driven symporter.; Induction: JEN1 of S. cerevisiae is induced by lactate.; Phenotype: Deletion of JEN1 in S. cerevisiae results in slow growth of yeast on synthetic medium supplemented with L-lactate.; Repression: JEN1 of S. cerevisiae is repressed by glucose.; Similarity: JEN1 of S. cerevisiae belongs to the sialate:H+ symporter (SHS) group of the major facilitator superfamily (MFS) of transport proteins.; Title: similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10198029; See PMID 10879467
An07g02550	Title: weak similarity to DNA dependent ATPase/DNA helicase B - Saccharomyces cerevisiae
An07g02560	Catalytic activity: dimethylallyltryptophan synthase of C. purpurea catalyses the reaction dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.; Function: dimethylallyltryptophan synthase of C. purpurea (also known as tryptophan dimethylallyltransferase) is a prenyltransferase, which catalyses the first step in ergot alkaloid biosynthesis.; Title: similarity to dimethylallyltryptophan synthase dmaW - Claviceps purpurea; See PMID 1605639; See PMID 7488077; See PMID 11036684
An07g02570	Pathway: TRI11 from F. sporotrichioides is involved in the trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 gene from Fusarium sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An07g02580	Remark: blastp matches are unspecific.
An07g02590	Title: weak similarity to hypothetical protein F13K23.8 - Arabidopsis thaliana
An07g02600	Similarity: G. cingulata homolog is similar to glutenins.; Title: similarity to hypothetical glutamine rich protein AAB92223.1 - Glomerella cingulata
An07g02650	Catalytic activity: EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site.; Function: the S. cerevisiae homolog YEF3/eEF-3 elongation factor 3 is a cytosolic protein required by the fungal ribosomes for protein synthesis. The requirement for EF-3 is unique to fungi.; Remark: S. cerevisiae EF-3 is a member of the non-transporter group of the ATP-binding cassette (ABC) superfamily.; Title: strong similarity to translation elongation factor 3 Yef3 - Saccharomyces cerevisiae
An07g02680	Complex: S. cerevisiae Chl12p/Cft18p is a subunit in an alternative replication factor c (RFC) complex RFC(Ctf18p, Ctf8p, Dcc1p). Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p,and Rfc5p.; Function: RFC(Ctf18p, Ctf8p, Dcc1p) is required for sister chromatid cohesion and faithful chromosome transmission durin mitosis.; Remark: an alternative gene name for the S. cerevisiae homolog CHL12 is CFT18.; Title: strong similarity to protein required for accurate chromosome transmission Chl12 - Saccharomyces cerevisiae
An07g02690	Function: PBK1 of H. sapiens could be involved in the regulation of proliferation/ differentiation and potentially in invasion of trophoblast cells.; Remark: PBK1 of H. sapiens is expressed in first trimester placentae but not in term placentae in the proximal parts of cell islands and in closely adjacent villous cytotrophoblast.; Remark: the ORF is shorter than PBK1 of H. sapiens (407 compared to 517 amino acids) and the similarity between the two proteins spans only a stretch of about 250 amino acids.; Remark: the ORF overlaps with the A. niger EST an_2460 in EMBLEST:BE759612.; Title: similarity to hypothetical regulational protein PBK1 - Homo sapiens; See PMID 9859858
An07g02700	Complex: ETFA of H. sapiens is a heterodimer of an alpha and a beta chain, that binds one molecule of FAD.; Function: ETFA of H. sapiens is an electron acceptor for any of several dehydrogenases in the mitochondrial matrix and it transfers the electrons to the mitochondrial respiratory chain via electron-transferring-flavoprotein dehydrogenase.; Phenotype: mutations in ETFA of H. sapiens can cause glutaricaciduria type IIA (excessive excretion of glutaric and other acids).; Remark: ETFA of H. sapiens belongs to the superfamily of electron transfer flavoprotein alpha chains.; Title: strong similarity to electron transfer flavoprotein alpha chain precursor ETFA - Homo sapiens; localisation:mitochondrion; See PMID 3170610
An07g02710	Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An07g02730	Function: Psu1 of S. pombe presumably plays an essential role in cell wall synthesis.; Phenotype: disruption of the gene for Psu1 in S. pombe revealed that it is essential for growth, and the null phenotype showed the swelling of cells followed by eventual lysis.; Remark: the ORF is rich in histidine and serine.; Remark: the ORF overlaps with the A. niger ESTs AN03F11 and ID NO:3882 in EMBLEST:ANI239807 and in PATENTDNA:AAF11359, respectively.; Title: strong similarity to SUN family protein su1p - Schizosaccharomyces pombe; See PMID 10462482
An07g02740	Remark: the ORF is rich in serine.; Remark: the similarity between the ORF and the S. pombe protein extends only over a stretch of about 200 amino acids.; Title: similarity to hypothetical protein encoded by SPAP14E8.02 - Schizosaccharomyces pombe
An07g02750	Remark: the ORF is short in sequence.
An07g02760	Function: human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.; Remark: NMD rids eukaryotic cells of aberrant mRNAs containing premature termination codons.; Remark: tethering of Upf of H. sapiens to the 3'UTR of beta-globin mRNA elicits nonsense-mediated decay (NMD).; Title: strong similarity to hUPF2 - Homo sapiens; See PMID 11163187
An07g02770	Similarity: the ORF is shorter than the S. cerevisiae protein (270 compared to 427 amino acids), the similarity between the two proteins is very high at a central stretch of about 50 amino acids.; Title: strong similarity to hypothetical protein YKL195w - Saccharomyces cerevisiae
An07g02780	Function: inv of M. musculus is essential for the left-right axis determination.; Remark: the ORF is much shorter than inv of M. musculus (273 compared to 1062 amino acids), the ORF is similar to the ankyrin domain repeated in inv of M. musculus.; Title: similarity to left-right axis determination protein inversin inv - Mus musculus; See PMID 9771707
An07g02790	Similarity: the similarity to mTPK of M. musculus is restricted to a short stretch at the N-terminusaof the M-musczlus protein.; Title: weak similarity to thiamin pyrophosphokinase mTPK1 - Mus musculus; See PMID 10567383
An07g02800	Similarity: the predicted ORF is 67 amino acids shorter at the N-terminus and 95 amino acids at the C-terminal end.; Title: strong similarity to hypothetical protein 2E4.30 - Neurospora crassa
An07g02810	Similarity: the predicted ORF shows similarity to several mitochondrial carrier proteins from different species.; Title: strong similarity to hypothetical mitochondrial carrier protein YMR166c - Saccharomyces cerevisiae
An07g02820	Title: strong similarity to hypothetical protein SPBC1539.04 - Schizosaccharomyces pombe
An07g02833	Title: strong similarity to EST SEQ ID NO:4186 from patent WO200056762-A2 - Aspergillus niger
An07g02840	Similarity: the ORF overlaps with the A. niger EST sequence in EMBLEST:BE759034 an_3317.; Title: strong similarity to cell division controll protein CDC3 - Candida albicans; See PMID 4203183
An07g02850	Remark: it is assumed, that sequences excluded from the ORF are CDS, but as the submitted sequence contains stop codons/putative frameshifts, the region was not included in the ORF sequence.; Remark: the ORF overlaps with A. niger EST in PATENTDNA:AAF11720 EST SEQ ID NO:4243.; Title: strong similarity to EST SEQ ID NO:4243 from patent WO200056762-A2 - Aspergillus niger
An07g02860	Function: Pob3 of S. cerevisiae is an essential nuclear protein, which physically and genetically interacts with the catalytic subunit of DNA polymerase alpha and probably modulates chromatin function during replication as well as in transcription.; Similarity: the predicted ORF is 107 amino acids longer at the C-terminus than S. cerevisiae Pob3.; Title: strong similarity to chromatin modelling protein Pob3 - Saccharomyces cerevisiae; nucleus; See PMID 9199353; See PMID 10413469; See PMID 10924459
An07g02870	Function: Rax2 of S. cerevisiae functions as a marker, indicating the cell poles (budding direction).; Remark: Rax2 of S. cerevisiae is inherited immutably at the cell cortex for multiple generations, and is shown to have a half-life exceeding several generations.; Title: similarity to membrane protein Rax2 -Saccharomyces cerevisiae; See PMID 11110666
An07g02880	Title: strong similarity to hypothetical protein EAA57627.1 - Aspergillus nidulans
An07g02890	Function: OOG1 of R. norvegicus is a DNA repair enzyme that exicises the oxidation product 8-hydroxyguanine (8-OH-G) out of the DNA.; Remark: 8-OH-G is one of the major DNA oxidation products caused by oxygen radicals (produced metabolically or induced by external agents) and ionizing radiation.; Remark: OOG1 of R. norvegicus belongs to the OGG1 family 1.; Remark: OOG1 of R. norvegicus has two functionalities: a 8-oxoguanine-DNA-glycosylase (EC 3. 2. 2. -) and a DNA-(apurinic or apyrimidinic site) lyase (EC 4. 2. 99. 18).; Title: strong similarity to 8-oxoguanine-DNA-glycosylase OOG1 - Rattus norvegicus; nucleus; See PMID 9587483; See PMID 10426809; See PMID 10882853
An07g02900	Complex: U2AF50 of D. melanogaster forms together with the U2AF small subunit the heterodimeric pre-mRNA splicing factor U2AF.; Function: U2AF50 of D. melanogaster is necessary for the splicing of pre-mRNA.; Remark: U2AF binds site specifically to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site at an early step in spliceosome assembly.; Remark: U2AF plays a critical role in 3' splice site selection.; Remark: U2AF50 of D. melanogaster belongs to the SR family of splicing factors.; Remark: the RS domains of the U2AF components of D. melanogaster are essential for RNA binding.; Similarity: the ORF is 127 amino acids shorter at the N-terminus than U2AF50 of D. melanogaster.; Title: strong similarity to splicing factor U2AF large chain U2AF50 - Drosophila melanogaster; nucleus; See PMID 9528748; See PMID 9632785; See PMID 7692602
An07g02910	Remark: the ORF has an unusual exon/intron structure for A. niger.
An07g02920	Remark: the ORF has an unusual exon/intron structure and short length (62 amino acids).; Similarity: the ORF shows similarity over a stretch of 47 amino acids to patent WO9306215-A (a hypothetical M. musculus nuclear receptor XR5).
An07g02940	Remark: the ORF has an unusual exon/intron structure for A. niger and short length (80 amino acids).; Title: questionable ORF
An07g02950	Remark: the ORF has an unusual exon/intron structure for A. niger.
An07g02960	Similarity: the ORF overlaps with A. niger EST from database entries EMBLEST:BE758805 (an_3049),EMBLEST:BE759822 (an_2743), EMBLEST:BE759687 (an_2554),EMBLEST:BE760011 (an_2967) and PATENTDNA:AAF12010 (EST SEQ ID NO:4002).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S13.e - Saccharomyces cerevisiae; cytoplasm
An07g02970	Remark: the translated sequence of the ORF probably contains some introns.; Title: strong similarity to hypothetical conserved protein SPBC146.06c - Schizosaccharomyces pombe
An07g02980	Similarity: the similarity of the ORF to the hypothetical protein YDR469w of S. cerevisiae is restricted to the second half of the ORF, where the homology is relatively high.; Title: similarity to hypothetical protein YDR469w -Saccharomyces cerevisiae
An07g02990	Function: AUF1 of H. sapiens is a component of the ribonucleosomes, that binds with high affinity to mRNA molecules, which contain AU-rich elements (ARES), a process that might control mRNA turnover.; Remark: AUF1 of H. sapiens is also called heterologous nuclear ribonucleoprotein D0, HNRNP D0,AU-rich element RNA-binding protein 1 or HNRPD.; Similarity: the alignment between the ORF and AUF1 of H. sapiens encompasses solely the N-terminal half of the ORF.; Title: similarity to RNA-binding protein AUF1 - Homo sapiens; See PMID 9932457; See PMID 11514570
An07g03000	Function: BR140 of H. sapiens is a probable transcription regulator.; Remark: BR140 of H. sapiens is also called peregrin,bromodomain and PDH finger-containing protein 1 or BRPF1.; Remark: bromodomains are found in several DNA-binding proteins; the PHD finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation.; Similarity: the ORF shows strong similarity to several BR140 homologues from different species.; Similarity: the similarity of the predicted ORF to BR130 of H. sapiens is locally high in the region between amino acid 337 and 828 of the ORF.; Title: strong similarity to zinc-finger protein BR140 - Homo sapiens
An07g03020	Function: O-sialoglycoprotein endopeptidase is a neutral metalloprotease (glycoprotease), which is specific for O-sialoglycoproteins such as glycophorin A, from which the 31-Arg-|-Asp-32 bond is cleaved.; Function: O-sialoglycoprotein endopeptidases do not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.; Repression: O-sialoglycoprotein endopeptidases are inhibited by EDTA (100 milli M) and 1,10-phenanthroline.; Similarity: the ORF shows strong similarity to O-sialoglycoprotein endopeptidases, especially from bacteria.; Title: strong similarity to O-sialoglycoprotein endopeptidase A1 - Pasteurella haemolytica; extracellular/secretion proteins; See PMID 9606137; See PMID 9689740; See PMID 1885539
An07g03030	Remark: the A. niger EST from patent WO200056762-A2 is found in PATENTDNA:AAF11604 as EST SEQ ID NO:4127.; Similarity: the ORF overlaps with A. niger ESTs an_2812 (EMBLEST:BE759877), an_2694 (EMBLEST:BE759780),an_2624 (EMBLEST:BE759723) and an_017 (EMBLEST:BE760090).; Title: strong similarity to EST SEQ ID NO:4127 from patent WO200056762-A2 - Aspergillus niger
An07g03040	Similarity: the similarity of the predicted ORF to the N. crassa protein is restricted to the second half of the ORFs.; Title: similarity to hypothetical protein 15E11.80 -Neurospora crassa
An07g03050	Similarity: the predicted ORF is 425 amino acids shorter at the N-terminus than the putative integral membrane protein SCC53. 26c of S. coelicolor and the similarity is restricted to an C-terminal region of the S. coelicolor protein.; Title: similarity to hypothetical integral membrane protein SCC53.26c - Streptomyces coelicolor
An07g03070	Function: ARALAR2 of H. sapiens is a calcium-dependent mitochondrial metabolite (possibly anionic) carrier, which might have a role in urea cycle function.; Remark: ARALAR2 of H. sapiens is also called SLC25A13, member 13 of solute carrier family 25 or citrin.; Title: strong similarity to mitochondrial carrier protein ARALAR2 - Homo sapiens; See PMID 10369257; See PMID 10610724; See PMID 10642534
An07g03090	Function: bimB of A. nidulans is involved in the nuclear division, probably as a component of the mitotic spindle.; Phenotype: a conditionally lethal mutation in the bimB gene of A. nidulans disrupts the normal regulatory patterns associated with mitotic events, e. g. DNA replication occurs in the absence of the completion of mitosis at restrictive temperature and large polyploid nuclei form after several hours.; Title: strong similarity to spindle pole body component bimB - Aspergillus nidulans; See PMID 1639810
An07g03100	Catalytic activity: carboxylesterases catalyse a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Title: strong similarity to esterase D ESD - Homo sapiens
An07g03110	Remark: similarity to A. niger EST an_2343 EMBLEST:BE75951.; Similarity: the encoded protein shows also similarity to the N-terminal half of An13g02370.; Title: similarity to hypothetical protein CAD21104.1 - Neurospora crassa
An07g03120	Title: similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans
An07g03130	Function: MMT1 of S. cerevisiae is involved in the iron import in mitochondria, which is required for the biosynthesis of heme and various iron-sulfur proteins.; Remark: the systematic name of MMT1 from S. cerevisiae is YMR177W.; Similarity: the ORF shows similarity to several cation transporters.; Similarity: the similarity of MMT1 (and MMT2=YPL224c) from S. cerevisiae to the ORF starts around amino acid 100.; Title: strong similarity to mitochondrial cation transporter Mmt1 - Saccharomyces cerevisiae; See PMID 10383398
An07g03140	Catalytic activity: XKS1 of S. cerevisiae converts ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate.; Function: XKS1 of S. cerevisiae is necessary for growth in culture media with D-xylulose as the sole carbon source, which can induce the production of ethanol.; Phenotype: overexpression of XKS1 from S. cerevisiae negatively influenced cell growth in xylulose.; Title: strong similarity to D-xylulokinase Xks1 -Saccharomyces cerevisiae; See PMID 9595677; See PMID 10981687; See PMID 11461146
An07g03150	Function: exportin-t of H. sapiens is a tRNA receptor, that shuttles between the nucleus and cytoplasm and exports tRNA out of the nucleus in a RanGTP-dependent manner.; Title: strong similarity to nuclear tRNA export receptor exportin-t - Homo sapiens; See PMID 9512417; See PMID 9660920
An07g03160	Catalytic activity: transaldolases catalyse sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate.; Function: transaldolases are important for the balance of metabolites in the pentose-phoshapte pathway and together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways.; Title: strong similarity to transaldolase talB -Synechocystis sp.; cytoplasm
An07g03170	Catalytic activity: SDH3 of S. cerevisiae catalyzes succinate + ubiquinone <=> fumarate + ubiquinol.; Function: SDH3 of S. cerevisiae is the cytochrome b560 subunit of the respiratory complex II, which is responsible for the transfer of electrons from succinate to ubiquinone.; Induction: SDH3 of S. cerevisiae is activated in the presence of the HAP2 transcriptional activator.; Remark: SDH3 of S. cerevisiae is also called CYB3,YKL141W or YKL4.; Title: strong similarity to succinate dehydrogenase cytochrome b subunit Sdh3 - Saccharomyces cerevisiae; localisation:mitochondrion
An07g03180	Remark: the predicted ORF contains long introns.
An07g03190	Title: weak similarity to hypothetical precursor of mitochondrial ribosomal protein Yml15 - Saccharomyces cerevisiae [putative sequencing error]
An07g03200	Function: AP47 of M. musculus is the medium chain of the clathrin-associated protein complex AP-1, which leads to membrane protein selection and concentation by binding to its cytoplasmic tails.; Localization: AP47 of M. musculus is a component of the plasma membrane adaptor.; Remark: AP47 is also called AP1M1, clathrin coated assembly protein AP47, Golgi adaptor AP-1 47 kDa protein,HA1 47 kDa subunit, AP-MU chain family member MU1.; Remark: a second AP-47 2 chain of M. musculus was identified recently.; Title: strong similarity to adaptor complex AP-1 medium chain AP47 - Mus musculus; See PMID 10640811
An07g03210	Function: Gtr1 of S. cerevisiae is associated with the function of the Pho84 inorganic phosphate transporter.; Function: ragA of H. sapiens, and its homologue Gtr1p of S. cerevisiae are G proteins, which are involved in the RCC1-Ran pathway.; Localization: ragA of H. sapiens was suggested to shuttle between the cytoplasm and the nucleus, depending on the bound nucleotide state.; Similarity: the ORF overlaps with A. niger EST an_3621 (EMBLEST:BE759269).; Title: strong similarity to ras-related GTPase ragA - Homo sapiens; See PMID 8886981; See PMID 9394008; See PMID 11073942
An07g03220	Title: strong similarity to hypothetical conserved protein 3H10.120 - Neurospora crassa [putative sequncing errors]
An07g03250	Title: similarity to hypothetical conserved protein B11N2.240 - Neurospora crassa
An07g03260	Similarity: the ORF encoded protein shows similarity to a variety of hypothetical transporters and weak similarity to several known transporters. Additionally the ORF encoded protein contains two PFAM domains related to transport mechanisms.; Title: similarity to hypothetical protein B15I20.50 - Neurospora crassa
An07g03270	Function: AADA6 of P. aeruginosa is able to confer high level resistance to streptomycin and spectinomycin.; Title: similarity to hypothetical aminoglycoside adenylyltransferase AADA6 - Pseudomonas aeruginosa; See PMID 10673049
An07g03280	Function: Gcd14p of S. cerevisiae is required for the biogenesis of tRNAiMet.; Title: similarity to tRNA Met processing protein Gcd14 - Saccharomyces cerevisiae; See PMID 10330157
An07g03290	Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Title: strong similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344
An07g03300	Title: weak similarity to virion membrane glycoprotein BPRF1 - Murid herpesvirus 4
An07g03320	Function: Kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli.; Title: similarity to kinesin light chain KLC -Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346
An07g03330	Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster
An07g03340	Function: HYP1 of A. fumigatus is a cell wall protein regularly arranged in interwoven fascicules of clustered proteinaceous microfibrils, or rodlets, to form the outer spore coat protein. It is involved in resistance to environmental stress and may well be associated with conidial hydrophobicity. It is important in the morphogenesis of the dispersible conidia.; Remark: RODA is an alternative name for HYP1.; Similarity: belongs to the fungal hydrophobin family.; Title: strong similarity to hydrophobin hYP1 -Aspergillus fumigatus; See PMID 7927699; See PMID 7927700
An07g03360	Title: similarity to hypothetical proline-rich protein - Schizosaccharomyces pombe
An07g03370	Function: YAR1 is required for normal rate of cell proliferation.; Title: similarity to ankyrin-like protein Yar1 -Saccharomyces cerevisiae; See PMID 8675027
An07g03380	Catalytic activity: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.; Function: UGCG of M. musculus is a glucosyltransferase that transfers glucose to ceramide.; Localization: UGCG of M. musculus is an integral membrane protein in the endoplasmic reticulum.; Pathway: UGCG of M. musculus catalyzes the first glycosylation step of glycosphingolipid synthesis.; Title: similarity to UDP-glucose ceramide glucosyltransferase UGCG - Mus musculus; endoplasmatic reticulum; See PMID 9623774; See PMID 9918791
An07g03390	Title: similarity to hypothetical protein SPBC342.06c - Schizosaccharomyces pombe
An07g03400	Title: weak similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus
An07g03410	Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae
An07g03420	Title: similarity to hypothetical protein SPAC17A5.16 - Schizosaccharomyces pombe
An07g03430	Title: strong similarity to hypothetical protein CAD70902.1 - Neurospora crassa
An07g03440	Title: similarity to hypothetical protein YHR045w -Saccharomyces cerevisiae
An07g03460	Function: IMG1 of s. cerevisiae is essential for respiration and maintenance of the mitochondrial genome.; Remark: PETCR46 and YCR046c are alternative names for IMG1 og s. cerevisiae.; Title: similarity to mitochondrial ribosomal protein Img1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8771712
An07g03470	Expression: DAL5 is a constitutively expressed allantoin system gene whose product is required for allantoate transport in yeast.; Remark: dal5 mutants of S. cerevisiae lack allantoate transport; these mutant strains also exhibit a 60% loss of allantoin transport capability.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 2651902; See PMID 3275614; See PMID 3549700
An07g03500	Title: weak similarity to hypothetical proline-rich protein - Schizosaccharomyces pombe
An07g03520	Catalytic activity: pcbera reduces the benzylic ether functionalities of both dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alcohol.; Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa [truncated ORF]; See PMID 10066819
An07g03540	Title: strong similarity to hypothetical protein encoded by An02g00500 - Aspergillus niger
An07g03550	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An07g03560	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g03570	Function: sou2 of C. albicans is required for L-sorbose assimilation.; Similarity: the ORF shows similarity to several short chain dehydrogenases/reductases from different species and with variuos substrate specificities.; Title: strong similarity to sorbitol utilization protein sou2 - Candida albicans
An07g03580	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g03590	Remark: the ORF shows similarity to several proline-rich or and serine-rich proteins.
An07g03600	Function: chloride channels have several functions in the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport.; Phenotype: clc1 mutant mice (ADR) are a model for recessive autosomal myotonia, in addition to Cl-conductance, many other parameters are changed in muscles of homozygous animals.; Similarity: the ORF shows similarity to several choride channels from different species, which are involved in various cellular processes.; Similarity: the similarity to the chloride channel proteins starts around amino acid 50 of the ORF.; Title: similarity to chloride channel protein clc1 -Mus musculus; See PMID 1659665
An07g03610	Title: similarity to hypothetical protein B13C5.110 - Neurospora crassa
An07g03620	Induction: the mRNA of cnaA in A. nidulans varies in a cell cycle-dependent manner with maximal levels found early in G1 and considerably before the G1/S boundary.; Phenotype: gene disruption of cnaA in A. nidulans by homologous recombination leads to growth-arrest and reveals that the cells they are blocked early in the cell cycle.; Title: strong similarity to calcineurin chain cnaA -Aspergillus nidulans; See PMID 11289309
An07g03630	Title: strong similarity to hypothetical protein B11N2.220 - Neurospora crassa
An07g03640	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An07g03660	Similarity: the ORF also overlaps with A. niger ESTs EMBLEST:BE759068, EMBLEST:BE75998, EMBLEST:BE760671 and EST SEQ ID NO:4064 from patent WO200056762-A2.; Similarity: the encoded protein also shows similarity to An09g00630.; Title: similarity to hypothetical protein CAD37045.1 - Neurospora crassa
An07g03670	Function: syg1 of S. cerevisiae mediates response to, or transduces signals through, G-protein beta or G beta gamma, e. g. the mating pheromone-initiated signal.; Phenotype: the mutant SYG1 delta 340 in S. cerevisiae can suppress the cell cycle arrest associated with gpa1, but the cells retain a differentiated morphology.; Remark: syg1 of S. cerevisiae is also called YIL047C.; Remark: the ORF shows similarity to the xenotropic and polytropic murine retrovirus receptors of several mouse species.; Title: strong similarity to plasma membrane receptor Syg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 7592711
An07g03680	Function: qutR of A. nidulans is active in the signal-transduction pathway that regulates transcription of the quinic acid utilization (qut) gene cluster in A. nidulans.; Phenotype: mutations in the qutR gene of A. nidulans alter qutR function such that the transcription of the qut gene cluster is permanently on (constitutive phenotype) or is insensitive to the presence of quinate (super-repressed phenotype).; Title: strong similarity to repressor protein qutR -Aspergillus nidulans; See PMID 8704987; See PMID 10926843
An07g03690	Function: ata1 of H. sapiens mediates Na+-dependent transport of system A neutral amino acids.; Induction: ata1 of H. sapiens is adaptively stimulated upon amino acid starvation of cultured human fibroblasts.; Similarity: the ORF shows similarity to several puatative membrane proteins/putative transporters from different species and with various function.; Title: strong similarity to amino acid transporter ata2 - Homo sapiens; See PMID 10930503; See PMID 11172802
An07g03710	Remark: the ORF is questionable due to the presence of only a single long exon.; Title: questionable ORF
An07g03720	Catalytic activity: NAD-dependent 15-hydroxyprostaglandin dehydrogenases catalyse (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD(+) <=> (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH.; Function: hpgd of R. norvegicus is involved in the reduction of prostaglandin E2, F2alpha and B1, but not of prostaglandin D2.; Title: strong similarity to NAD-dependent 15-hydroxyprostaglandin dehydrogenase hpgd - Rattus norvegicus; See PMID 9099857
An07g03730	Title: strong similarity to hypothetical protein ybiU - Escherichia coli
An07g03740	Similarity: the ORF also shows strong similarity to the probable membrane protein YCL045c of S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC25H1.07 - Schizosaccharomyces pombe
An07g03750	Function: sec14 of Y. lipolytica is a phosphatidylglycerol/phosphatidylinositol transfer protein required for differentiation of the dimorphic yeast from the yeast to the mycelial form.; Remark: sec14 of Y. lipolytica is also called PI/PC TP.; Similarity: the predicted ORF is around 80 amino acoids longer at its C-terminal end than sec14 of several species, but 65 amino acids shorter than EC14 of Y. lipolytica.; Title: strong similarity to phosphatidylinositol-phosphatidylcholine transfer protein SEC14 - Yarrowia lipolytica; See PMID 11179668
An07g03760	Function: snd1 of H. sapiens is as coactivator involved in gene transcription probably by interacting with TFIIE and other myb transcription factors.; Phenotype: H. sapiens snd1 overexpression specifically augmented EBNA 2 acidic domain-mediated activation of gene transcription.; Phenotype: snd1 of H. sapiens is essential for normal cell growth, since cell viability was reduced by antisense p100 RNA and restored by sense p100 RNA expression.; Title: strong similarity to 100 kDa coactivator snd1 - Homo sapiens; See PMID 7651391; See PMID 9003410; See PMID 9041650; See PMID 11124528
An07g03770	Catalytic activity: superoxide dismutases convert 2 peroxide radical + 2 H(+) <=> O(2) + H(2)O(2).; Function: superoxide dismutases (SOD) are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide.; Repression: potassium cyanide and diethyldithiocarbamate, known Cu,Zn SOD inhibitors, caused inhibition of the purified sodC of A. fumigatus at working concentrations of 0. 25 mM, whilst sodium azide and o-phenanthroline demonstrated inhibition at higher concentrations (10-30 mM).; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE759823, EMBLEST:BE76050 and EMBLEST:BE760712.; Title: strong similarity to Cu,Zn superoxide dismutase sodC - Aspergillus fumigatus; See PMID 7633574
An07g03780	Remark: A. niger EST EMBLEST:AN741 shows weak similarity to the predicted ORF.
An07g03790	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An07g03810	Catalytic activity: thymidylate synthases convert 5,10-methylenetetrahydrfolate + DUMP = dihydrofolate + DTMP.; Function: SPAC15E1. 04 of S. pombe is involved in deoxyribonucleotide biosynthesis.; Remark: the prediction of the ORF structure is questionable, as its lenght is only 49 amino acids.; Title: weak similarity to hypothetical thymidylate synthase-like DNA metabolism protein SPAC15E1.04 -Schizosaccharomyces pombe
An07g03820	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An07g03830	Function: panB of A. nidulans is part of an alkaline ambient pH signal transduction pathway, which senses ambient pH and transduces a signal to trigger the transcription factor PacC processing.; Function: the panB regulated protein pacC of A. nidulans is a zinc finger transcriptional regulator, which is, at alkaline ambient pH, proteolytically processed to a functional form serving as an activator of alkaline-expressed genes and a repressor of acid-expressed genes.; Similarity: the predicted ORF is 700 amino acids shorter than the calpain-like protease PalBory from A. oryzae and the similarity is only high in its C-terminus starting with amino acid 108.; Similarity: the similarity of the ORF to the palB protein of A. nidulans is restricted to a structural domain of calpain-related proteins with unknown function (domain III).; Title: weak similarity to calpain-like cysteine protease palB - Aspergillus nidulans
An07g03850	Catalytic activity: tal1 of S. cerevisiae catalyses sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate.; Function: tal1 of S. cerevisiae is important for the balance of metabolites in the pentose-phosphate pathway.; Phenotype: tal1 transaldolase-deficient S. cerevisiae strains accumulated sedoheptulose 7-phosphate,an intermediate of the pentose-phosphate pathway.; Remark: tal1 of S. cerevisiae is also called L9638. 6 or YLR354c.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE760370 and EMBLEST:BE759174.; Title: strong similarity to transaldolase Tal1 -Saccharomyces cerevisiae; cytoplasm
An07g03860	Protein sequence is in conflict with the conceptual translation; Function: lvsA (volume sphere A) of D. discoideum has an important role in a membrane-processing pathway that is essential for cytokinesis, probable by regulating lysosomal membrane traffic, as it shows homology to the beige protein.; Similarity: the ORF overlaps with A. niger EST an_3046, EMBLEST:BE758802.; Similarity: the predicted ORF is 1107 amino acid shorter at its N-terminus than lvsA of D. discoideum.; Title: strong similarity to beige protein homolog lvsA - Dictyostelium discoideum [putative sequencing error]; putative sequencing error; See PMID 10588668
An07g03870	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 117 amino acids long.; Title: questionable ORF
An07g03880	Gene-ID: pepC; Mapping: pepC from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 9309173.; Remark: the proposed gene model of pepC from A. niger differs from the published sequence because an additional intron was introduced (based on cDNA data). This new model has higher homology with the P. citrinum alkaline serine protease Pen c2.; Similarity: the ORF overlaps with A. niger EST an_3439 (EMBLEST:BE759117), the sequence for A. niger subtilisin-like serine protease pepC (EMBL:ANPEPC) and patent AU9336959-A decribing the subtilisin-like serine protease PEPC from A. niger (PATENTDNA:AAQ52535).; Similarity: the predicted ORF varies from the protein sequence of PATENTPROT:AAR44433 and PIR JU0146 in the two positions S398P and R525L.
An07g03890	Catalytic activity: S. cerevisiae cdc34 catalyses ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Function: S. cerevisiae cdc34 catalyzes the covalent attachment of ubiquitin to several protein, which finally leads to degradation by the proteasome.; Phenotype: mutants in the gene CDC34 of S. cerevisiae are defective in the transition from G1 to the S phase of the cell cycle, a process, which is also controlled by the degradation of cyclin-dependent kinases.; Remark: cdc34 of S. cerevisiae is also called ubc3,DNA6 or YDR054C.; Remark: the ORF overlaps with database entries containing the 3' untranslated region of pepC from A. niger, which is encoded on ORF 30WK.; Title: strong similarity to ubiquitin conjugating enzyme Cdc34 - Saccharomyces cerevisiae; See PMID 8939846; See PMID 10975521
An07g03900	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 78 amino acids long.; Title: questionable ORF
An07g03910	Remark: the ORF has a suboptimal intron-exon structure.; Title: questionable ORF
An07g03920	Function: bile acid transport essentially takes place out of mammalian hepatocytes into the bile.; Remark: YBT1 of S. cerevisiae is also called BAT1 or YLL048.; Similarity: the ORF shows strong similarity to several ABC-transporters from different species and with various substrate specificities.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae
An07g03930	Remark: the intron-exon structure is suboptimal.
An07g03940	Function: the amdA transcriptional activator from A . nidulans is involved in the induction of the A. nidulans structual gene amdS (acetamidase), i. e. mediates acetate induction.; Phenotype: semi-dominant mutations in the amdA gene of A. nidulans lead to elevated expression of the gene encoding acetamidase amdS.; Similarity: the ORF shows homology to several DNA binding regulatory proteins.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 8119589; See PMID 9126617
An07g03950	Function: Clkr27 of C. lanceolata is an integral part of the fatty acid synthase type II, which is involved in fatty acid biosynthesis.; Similarity: the ORF shows similarity to several oxidoreductases from different species with various cellular activities.; Title: strong similarity to beta-ketoacyl-ACP reductase Clkr27 - Cuphea lanceolata
An07g03960	Catalytic activity: amidases catalyse a monocarboxylic acid amide + H(2)O <=> a monocarboxylate + NH(3).; Similarity: the ORF shows strong similarity to amidases from several species.; Title: strong similarity to amidase - Rhodococcus sp.; See PMID 2001397
An07g03970	Remark: the gene product of the mtr locus of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa
An07g03980	Function: OSM1 of P. grisea is involved in controlling the response to hyperosmotic stress by regulating cellular turgor.; Induction: exposure of M. grisea appressoria to external hyperosmotic stress induced OSM1-dependent production of arabitol, which acts as the major compatible solute to accumulating glycerol.; Phenotype: M. grisea delta OSM1 mutants showed a dramatically reduced ability to accumulate arabitol in the mycelium.; Title: strong similarity to osmotic sensitivity MAP Kinase OSM1 - Pyricularia grisea; See PMID 10521531
An07g03990	Function: SPCC1739. 03 of S. pombe is possibly involved in the decay of mRNA containing nonsense codons.; Similarity: the ORF overlaps with A. niger ESTs Nig022 (EMBLEST:AN74) and Nig022c (EMBLEST:AN742).; Title: strong similarity to hypothetical ATP binding protein SPCC1739.03 - Schizosaccharomyces pombe
An07g04000	Function: SPT8 of S. cerevisiae is a member of the yeast SAGA complex, in which SPT8 is required for TBP function at particular promoters probably by promoting a functional interaction between SPT3 and TBP.; Phenotype: mutations in SPT8 of S. cerevisiae confer phenotypes similar to those caused by particular mutations in SPT15, which encodes the TATA-binding protein (TBP).; Similarity: due to the presence of a WD-repeat motive, the ORF shows homology to beta transducin-like proteins, which is a subunit of G-proteins.; Title: strong similarity to transcription factor Spt8 - Saccharomyces cerevisiae; See PMID 8088510; See PMID 10101163; See PMID 10611242
An07g04020	Function: SKY1 of S. cerevisiae is regulating the targeting of serine/arginine-rich pre-mRNA splicing factors.; Phenotype: S. cerevisiae SKY1 mutants shows slow growth and decreased in vivo phosphorylation of the shuttling protein NPl3.; Similarity: the ORF is 317 amino acids shorter than SKY1 of S. cerevisiae; Similarity: the ORF shows similarity to several protein kinases with different cellular functions.; Title: strong similarity to protein kinase Sky1 -Saccharomyces cerevisiae; See PMID 10225947; See PMID 10318902; See PMID 11113192
An07g04030	Similarity: the hypothetical protein SPBC19C2. 08 of S. pombe is 124 amino acid shorter than the predicted ORF.; Title: strong similarity to hypothetical protein SPBC19C2.08 - Schizosaccharomyces pombe
An07g04040	Similarity: the similarity of the ORF to the putative protein mlr7324 of M. loti is restricted to the second half of the ORF.; Title: similarity to hypothetical protein mlr7324 -Mesorhizobium loti
An07g04060	Remark: the A. niger patent WO200056762-A2has database entry number PATENTDNA:AAF11789 SEQ ID NO:4312.; Title: strong similarity to EST SEQ ID NO:4312 from patent WO200056762-A2 - Aspergillus niger
An07g04070	Function: WSC4 of S. cerevisiae is believed to be involved in RHO protein signal transduction, cell wall organization and biogenesis, and heat shock response.; Remark: WSC4 of S. cerevisiae is also called YHC8 or YHL028W.; Similarity: the similarity of the predicted ORF to WSC4 of S. cerevisiae is restricted to its N-terminal half (ending with amino acid 194) and the ORF is 292 amino acids shorter.; Title: similarity to stress response receptor Wsc4 -Saccharomyces cerevisiae
An07g04080	Remark: the predicted ORF contains on unusually long intron.; Title: questionable ORF
An07g04090	Remark: the patent WO200056762-A2 is found in PATENTDNA:AAF11704 SEQ ID NO:4227.; Title: similarity to EST SEQ ID NO:4227 from patent WO200056762-A2 - Aspergillus niger
An07g04100	Similarity: shares local similarity with a N-terminally located domain of fatty acid amide hydrolase from Rattus norvegicus.
An07g04110	Similarity: shows local similarity to a highly conserved domain of mammalian RAG2 proteins.; Title: weak similarity to hypothetical recombination activating protein 2 RAG2 - Pteropus giganteus
An07g04120	Similarity: a blast search produces multiple randomly distributed matches to diverse Arg/Glu- and Pro-rich proteins.
An07g04130	Function: Rad30 of S. cerevisiae is capable of error-free replication of UV-damaged DNA.; Function: Rad30 of S. cerevisiae transgresses cis-syn T-T dimers which normally block DNA replication progress and incorporates two adenines in the daughter strand.; Remark: possible sequencing error at position 51965 altering the intron donor GT to GA, alternatively this might be a rare splice site or the ORF might indeed be unspliced (the annotated intron is in frame).; Remark: the C-terminal third of Eso1 of S. pombe is homologous to and shares the function of the sister chromatid cohesion establishment protein Eco1 of S. cerevisiae.; Remark: the N-terminal two thirds of Eso1 of S. pombe are homologous to and share the function of DNA polymerase eta (Rad30) of S. cerevisiae which is involved in cis-syn T-T dimer translesion DNA synthesis.; Similarity: the A. niger ORF also shows strong similarity to DNA polymerase eta (Rad30) of S. cerevisiae (sytematic gene name YDR419w).; Similarity: the A. niger ORF shows similarity only to the N-terminal two thirds of Eso1 of S. pombe which are homologous to DNA polymerase eta (Rad30) of S. cerevisiae.; Title: strong similarity to sister chromatid cohesion protein eso1p - Schizosaccharomyces pombe [putative sequencing error]; See PMID 9974380; See PMID 10601233; See PMID 10779336
An07g04147	Remark: the EST sequence matches the complementary strand.; Title: similarity to EST an_1643 - Aspergillus niger
An07g04160	Similarity: the blastp produces a staggering amount of random hits against diverse proline-rich (eg expansin-like) proteins.; Title: strong similarity to FLO11 gene expression regulator An34 from patent WO200257456-A2 - Unclassified organism
An07g04170	Remark: the cDNA encoding LckSH3 domain-combining protein is patented under PATENTDNA:X40398.; Title: weak similarity to LckSH3 domain-combining protein from patent JP11080196-A - Homo sapiens
An07g04180	Catalytic activity: NADH + H(+) + ubiquinone = NAD(+) + ubiquinol.; Complex: complex I is composed of about 40 different subunits.; Function: complex I of N. crassa transfers electrons from NADH to the respiratory chain (ubiquinone).; Function: the 9. 5 kD subunit of complex I of N. crassa binds ubiquinone.; Similarity: the CDS is identical to the A. niger EST sequence from the DNA patent PATENTDNA:F11443 (Aspergillus niger EST SEQ ID NO:3966).; Title: strong similarity to 9.5 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1445878; See PMID 1445879
An07g04190	Catalytic activity: dolichyl diphosphooligosaccharide + protein L-Asn = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-Asn.; Complex: DDOST of G. gallus is an heterotrimeric complex of a 67kD (ribophorin I), a 63/64 kD (ribophorin II) and a 48 kD subunit.; Function: N-oligosaccharyl transferase catalyses the transfer of a high-mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins.; Function: the 48kD chain constitutes an essential subunit of N-oligosaccharyl transferase of G. gallus.; Remark: an alternative name for DDOST is N-oligosaccharyltransferase.; Title: strong similarity to dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kD chain DDOST - Gallus gallus; endoplasmatic reticulum; See PMID 8175777
An07g04200	Catalytic activity: triacylglycerol + H2O = diacylglycerol + a fatty acid anion.; Localization: triacylglycerol lipase of C. familiaris is secreted.; Title: strong similarity to precursor of triacylglycerol lipase - Canis lupus; extracellular/secretion proteins; See PMID 10520456; See PMID 1935982
An07g04230	Title: weak similarity to outer membrane protein from patent WO9640893-A1 - Helicobacter pylori
An07g04240	Function: krev-1 of N. crassa is probably involved in the regulation of sexual cycle progression.; Phenotype: overexpression of krev-1 from N. crassa in S. cerevisiae resulted in a random budding pattern.; Similarity: belongs to the ras superfamily of small GTPases.; Title: strong similarity to low-molecular-weight GTP/GDP-binding protein krev-1 - Neurospora crassa; See PMID 9267439
An07g04250	Title: strong similarity to hypothetical protein encoded by An05g02120 - Aspergillus niger
An07g04260	Catalytic activity: acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methyglutaryl-CoA + CoA-SH.; Function: HMGS of S. cerevisiae condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA,which is the substrate for HMG-CoA reductase leading to mevalonate.; Pathway: HMGS of S. cerevisiae is involved in the ergosterol biosynthesis pathway.; Remark: an alternative name for HMGS is ERG13.; Title: strong similarity to 3-hydroxy-3-methylglutaryl-CoA synthase Erg13 -Saccharomyces cerevisiae; See PMID 6148937; See PMID 9784867
An07g04270	Catalytic activity: MCC of H. sapiens converts 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA utilizing bicarbonate.; Catalytic activity: the carboxylation of 3-methylcrotonyl-CoA is energy-driven by the hydrolysis of ATP to ADP and phosphate.; Complex: MCCB of H. sapiens forms part of MCC consisting of one alpha and several beta subunits.; Pathway: MCC of H. sapiens catalyses a critical step in the leucine degradation pathway.; Title: strong similarity to 3-methylcrotonyl-CoA carboxylase (MCC) non-biotin-containing beta subunit MCCB -Homo sapiens; localisation:mitochondrion; See PMID 11170888; See PMID 11181649; See PMID 11406611
An07g04280	Catalytic activity: AtIVD activity requires FAD as a cofactor.; Catalytic activity: AtIVD of A. thaliana catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.; Complex: AtIVD of A. thaliana probably forms a homodimer.; Function: AtIVD of A. thaliana is also able to metabolize the valine degradation intermediate isobutyryl-CoA.; Function: the electrons from the substrate are transferred via ETF (electron-transferring flavoprotein) and ETF-dehydrogenase to ubiquinol.; Pathway: AtIVD of A. thaliana catalyzes an intermediate step in the leucine degradation pathway.; Title: strong similarity to isovaleryl-coenzyme A dehydrogenase AtIVD - Arabidopsis thaliana; localisation:mitochondrion; See PMID 11402190
An07g04290	Function: MARCKS of patent Y95899 is involved in the regulation of mucus secretion.; Similarity: other matches with bettter expect values were rejected due to length incongruency.; Similarity: weakly homologous to protein of patent database entry PATENTPROT:Y95899.; Title: weak similarity to myristoylated alanine-rich C kinase substrate MARCKS from patent WO200050062-A2 -Homo sapiens
An07g04300	Catalytic activity: MCC of H. sapiens converts 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA utilizing bicarbonate.; Catalytic activity: the carboxylation of 3-methylcrotonyl-CoA is energy-driven by the hydrolysis of ATP to ADP and phosphate.; Complex: MCCA of H. sapiens forms part of MCC consisting of one alpha and several beta subunits.; Function: MCCA of H. sapiens binds biotin.; Pathway: MCC of H. sapiens catalyses a critical step in the leucine degradation pathway.; Title: strong similarity to 3-methylcrotonyl-CoA carboxylase (MCC) biotin-containing alpha subunit MCCA -Homo sapiens; localisation:mitochondrion; See PMID 11170888; See PMID 11181649; See PMID 11401427; See PMID 11406611
An07g04320	Catalytic activity: D-arabinitol + NAD(+) = D-ribulose + NADH(+).; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655
An07g04330	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An07g04390	Catalytic activity: oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Complex: FAD is noncovalently bound to A. oxidans 6-HDNO.; Function: A. oxidans 6-HDNO is involved in nicotine-acetyl-CoA catabolism.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516
An07g04400	Function: the C. reinhardtii class V protein is postulated to be a component of the zygote cell wall.; Title: strong similarity to class V zygote-specific protein - Chlamydomonas reinhardtii; See PMID 1552907
An07g04410	Title: similarity to hypothetical protein encoded by An16g01460 - Aspergillus niger
An07g04420	Catalytic activity: beta-galactosidases hydrolyse terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Function: A. niger lacA is involved in carbohydrate utilisation.; Induction: high expression of A. niger lacA was detected on arabinose, xylose, xylan, and pectin.; Title: strong similarity to secreted beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 10347026; See PMID 1368193
An07g04430	Function: S. pombe Ght2 shows substrate specificity for D-glucose.; Function: expression of the S. pombe Ght1, Ght2,Ght5, and Ght6 genes in the S. cerevisiae mutant RE700A functionally complement its D-glucose uptake-deficient phenotype.; Similarity: S. pombe Ght2 belongs to the sugar porter subfamily within the major facilitator superfamily.; Similarity: the C-terminal region of the predicted A. niger ORF is identical to EST an_0692 Aspergillus niger,EMBLEST:BE760803.; Title: strong similarity to hexose transporter ght2p - Schizosaccharomyces pombe; plasma membrane; See PMID 10735857
An07g04440	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An07g04450	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An07g04460	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An07g04470	Catalytic activity: cholinesterases convert an acylcholine + H(2)O to choline + a carboxylic acid anion.; Title: strong similarity to butyrylcholinesterase BChE - Oryctolagus cuniculus; See PMID 7925428
An07g04480	Similarity: the C-terminal region of the predicted A. niger protein shows similarity to the C-terminal domain of S. coelicolor SCD8A. 32c.; Similarity: the N-terminus of the predicted A. niger protein shows similarity to the acidic C-terminal domain of two mRNA interacting proteins from S. cerevisiae, NMD2 and IFS1.; Title: strong similarity to hypothetical protein EAA64298.1 - Aspergillus nidulans
An07g04490	Similarity: similarity is from the central region of the predicted A. niger protein to the central region of human trans-Golgi 230p, which is 1700 aa longer.; Title: weak similarity to trans-Golgi p230 - Homo sapiens; See PMID 8626529
An07g04500	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and proline rich proteins.
An07g04520	Remark: ORF 5'truncated due to end of contig.; Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans [truncated ORF]
An07g04530	Remark: ORF 5'truncated due to end of contig.; Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF [truncated ORF]
An07g04540	Title: similarity to hypothetical protein SPBC1685.08 - Schizosaccharomyces pombe
An07g04550	Title: strong similarity to hypothetical yellow-related protein - Deinococcus radiodurans
An07g04560	Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: A. parasiticus norA is genomically localised within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conducive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: A. parasiticus norA belongs to the aldo/keto reductase 2 family.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042
An07g04570	Function: N. crassa Hex1 is required for the assembly of the Woronin body, a new category of peroxisome with a function in the maintenance of cellular integrity.; Function: deletion of HEX1 in N. crassa eliminates Woronin bodies from the cytoplasm and results in hyphae that exhibit a cytoplasmic-bleeding phenotype in response to cell lysis.; Localization: in N. crassa immunoelectron microscopy shows localization of Hex1 to the matrix of the Woronin body.; Remark: a possible sequencing error leads to a frame shift.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hex1 - Aspergillus nidulans [putative frameshift]; peroxisome; putative frameshift; See PMID 10783241
An07g04590	Function: human SRm300, a 300-kDa nuclear matrix antigen, functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA,including snRNPs and SR family proteins.; Function: specific depletion of human SRm300 does not prevent the splicing of pre-mRNAs.; Remark: ORF 5'truncated due to end of contig.; Title: similarity to splicing coactivator subunit SRm300 - Homo sapiens [truncated ORF]; nucleus; See PMID 10668804
An07g04600	Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.
An07g04610	Catalytic activity: epoxide hydrolases convert an epoxide + H(2)O to a glycol.; Function: rat epoxide hydrolase acts on epoxides (alkene oxides, oxiranes) and arene oxides, degrading potential toxic epoxides and determining steady state levels of physiological mediators.; Localization: rat epoxide hydrolase has been localised to the microsomal fraction.; Title: similarity to epoxide hydrolase - Rattus norvegicus; See PMID 8349641; See PMID 10720753
An07g04620	Similarity: the predicted A. niger ORF is identical to two sets of A. niger ESTs, an_2385 and an_3026 aligning for the first 390 bp, while an_3615, an_2148 and an_1658 align from bp 400 on.; Title: strong similarity to hypothetical protein EAA60744.1 - Aspergillus nidulans
An07g04630	Remark: an error occured concerning the TREMBL accesion no. which should read AF137223 instead of AF137223_1.; Title: weak similarity to mixed lineage leukemia-like protein Mll - Chanos chanos; See PMID 10468597
An07g04650	Catalytic activity: exo-beta-1,3-glucanases successively hydrolyse beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: S. cerevisiae BGL2 shows lectin-like binding to beta-1,3-glucan and chitin and is involved in carbohydrate utilisation.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. cerevisiae BGL2,which is 300 aa shorter.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; cell wall; See PMID 2509432
An07g04660	Title: similarity to hypothetical protein CAD25113.1 - Encephalitozoon cuniculi; See PMID 2690004
An07g04670	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An07g04680	Remark: blastp shows significant similarity (57% positives) between the predicted A. niger protein and P. falciparum PFC0920w but due to shortness of both peptides the calculated probability is low (p=1,5).; Title: similarity to hypothetical histone H2A variant PFC0920w - Plasmodium falciparum
An07g04690	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An07g04700	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and argenine rich proteins.
An07g04710	Similarity: similarity is from the predicted A. niger protein to the N-terminal region of human engrailed 1, which is 150 aa longer.; Title: weak similarity to homeotic protein engrailed 1 - Homo sapiens
An07g04730	Remark: also strong similarity to human Gene #6 associated peptide #4 patent WO200107459-A1.; Title: strong similarity to gene #6 associated peptide #4 from patent WO200107459-A1 - Homo sapiens
An07g04740	Remark: a splice site was detected upstream of the START codon.
An07g04750	Title: questionable ORF
An07g04760	Remark: only a glycin rich region is matching to homologe proteins.
An07g04770	Remark: the highly acidic nature of the NF-180 sidearm, makes it unlikely that phosphorylation of sidearm residues regulates interfilament spacing and axon diameter through global electrostatic repulsion of the carboxy-terminus away from the filament backbone.; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; See PMID 7770000
An07g04780	Catalytic activity: ATP + H2O = ADP + orthophosphate.; Remark: overexpression of myo2+ results in the inhibition of cytokinesis; cells become elongated and multinucleate and fail to assemble a functional cytokinetic actin ring and are either aseptate or form aberrant septa.; Remark: these results suggest that a contractile actin-myosin based cytokinetic mechanism appeared early in the evolution of eukaryotic cells and further emphasise the utility of fission yeast as a model organism in which to study the molecular and cellular basis of cytokinesis.; Title: strong similarity to myosin II myo2p -Schizosaccharomyces pombe; See PMID 9415380
An07g04790	Remark: Isy1p is part of the splicing machinery,associated with spliceosomes throughout the splicing reactions. At least a portion of the Isy1 protein population is associated with snRNAs; low levels of U5 and U6 snRNAs are coimmunoprecipitated specifically with Isy1p.; Remark: also strong similarity to Human ORFX ORF1702 polypeptide sequence SEQ ID NO:3404 patent WO200058473-A2.; Remark: alternative name is Isy1p.; Title: strong similarity to pre-mRNA splicing factor Utr3 - Saccharomyces cerevisiae; See PMID 10094305
An07g04800	Function: the patent holder claims the GTP-binding protein to be important for treating and/or diagnosing diseases associated with GBAP (guanosine triphosphate-binding associated proteins) expression, such as cancer, diabetes and asthma, but nothing is mentioned about direct involvement in signal transduction.; Remark: strong similarity to human GTP-binding associated protein #8 of patent WO200105970-A2 found in PATENTPROT:AAB68508.; Title: strong similarity to GTP-binding associated protein #8 from patent WO200105970-A2 - Homo sapiens
An07g04810	Remark: YNL275w encodes a nonglycosylated anion transport protein, localized to the plasma membrane. The protein did not bind to concanavalin A by lectin blotting or lectin affinity chromatography. The expressed protein bound specifically to a stilbene disulfonate inhibitor resin (SITS-Affi-Gel), and this binding could be competed by certain anions (HCO3-, Cl-, NO3-, and I-) but not by others (SO4(2-) and PO4(3-)).; Title: strong similarity to anion transporter YNL275w - Saccharomyces cerevisiae; See PMID 11401825
An07g04820	Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.; Pathway: inositol phosphate metabolism.; Remark: mammalian Vps34p plays a direct role in targeting lysosomal enzyme precursors to the endocytic pathway in an analogous fashion to its role in the fusion of early endocytic vesicles with endosomes.; Similarity: belongs to the class III phosphoinositide 3-kinases.; Title: strong similarity to phosphatidylinositol 3-kinase vps34 - Rattus norvegicus; See PMID 11171063
An07g04830	Title: similarity to hypothetical protein BAA90881.1 - Homo sapiens
An07g04840	Title: weak similarity to protein fragment SEQ ID NO:33868 from patent EP1033405-A2 - Arabidopsis thaliana
An07g04850	Title: strong similarity to hypothetical protein AAM96660.1 - Sphingobium chlorophenolicum
An07g04860	Function: in pancreatic beta-cells, the high Km glucose transporter GLUT2 catalyzes the first step in glucose-induced insulin secretion by glucose uptake.; Induction: the expression of GLUT2 is regulated by glucose at the transcriptional level.; Title: similarity to hepatic glucose transport protein GLUT2 - Mus musculus; plasma membrane; See PMID 7929431; See PMID 1765007
An07g04870	Function: RAD53 controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints.; Function: RAD53 phosphorylates proteins on serine,threonine, and tyrosine.; Localization: RAD53 was localized to the nucleus by immunofluorescence.; Phenotype: RAD53 is essential for viability.; Title: similarity to protein kinase Rad53 -Saccharomyces cerevisiae; nucleus; See PMID 1899289; See PMID 8355715
An07g04880	Title: weak similarity to translation initiation factor eIF-2 alpha chain kinase HCR - Rattus norvegicus
An07g04900	Remark: The EST sequence is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to EST an_2589 -Aspergillus niger
An07g04910	Title: weak similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans
An07g04920	Title: similarity to hypothetical protein CAD37023.1 - Neurospora crassa
An07g04930	Title: weak similarity to secreted polypeptide SEQ ID NR:98 from patent WO2003093453-A2 - Bacillus licheniformis
An07g04940	Complex: HOC1 is a subunit of the ANP1-HOC1-MNN11-MNN9 mannosyltransferase complex of the Golgi involved in cell wall integrity.; Golgi; Localization: Immunofluorescence studies localized HOC1 to the Golgi apparatus.; Remark: In S. cerevisiae many of the N-linked glycans on cell wall and periplasmic proteins are modified by the addition of mannan, a large mannose-containing polysaccharide.; Similarity: HOC1 strongly resembles OCH1, a yeast alpha-1,6-mannosyltransferase.; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 11095735
An07g04950	Title: weak similarity to hypothetical protein KIAA1394 - Homo sapiens
An07g04960	Title: similarity to hypothetical beta transducin-like protein het-e1 - Podospora anserina
An07g04970	Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger
An07g04980	Function: translocation of neutral aliphatic and aromatic amino acids across the plasma membrane of the ascomycete Neurospora crassa requires a functional gene product of the mtr locus.; Title: similarity to N amino acid transport system protein mtr - Neurospora crassa; plasma membrane; See PMID 1838345; See PMID 2843424
An07g04990	Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe
An07g05000	Catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L-glutamate + NADH.; Induction: PUT2 expression is induced by proline.; Pathway: PUT2 catalyzes the second step in the conversion from proline to glutamate.; Remark: proline is converted to glutamate in the yeast S. cerevisiae by the sequential action of two enzymes, proline oxidase and delta 1-pyrroline-5-carboxylate dehydrogenase.; Title: strong similarity to 1-pyrroline-5-carboxylate dehydrogenase precursor Put2 -Saccharomyces cerevisiae; See PMID 3062363; See PMID 6358862
An07g05010	Remark: faoP has a covalently bound flavin adenine dinucleotide as a prosthetic group.; Remark: faoP is a fructosyl valine-specific enzyme.; Remark: faoP is an enzyme that can be used for the determination of glycated proteins in blood samples from diabetic patients.; Title: strong similarity to fructosyl amino acid oxidase faoP - Penicillium janthinellum; See PMID 8534116
An07g05020	Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae
An07g05030	Title: weak similarity to arylsulfotransferase astA - Eubacterium rectale
An07g05040	Function: PUT1 converts proline to delta-1-pyrroline-5-carboxylate.; Induction: PUT1 expression is induced by proline and oxygen in the cell.; Localization: PUT1 has a characteristic mitochondrial import signal and the enzyme is localized in the mitochondrial matrix.; Pathway: PUT1 catalyzes the first step in the conversion from proline to glutamate.; Title: strong similarity to proline oxidase Put1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3125423; See PMID 3537723
An07g05050	Catalytic activity: L-proline + NAD(P)(+) <=> 1-pyrroline-5-carboxylate + NAD(P)H.; Pathway: P5CR catalyzes the final step in proline biosynthesis.; Title: similarity to pyrroline-5-carboxylate reductase P5CR - Neurospora crassa; See PMID 7565596
An07g05060	Title: strong similarity to protein kinase catalytic chain homolog DC2 - Drosophila sp.; See PMID 3215511
An07g05080	Function: vacuolar ATPase are responible for acidifying a variety of intracellular compartment in eukaryotic cells.; Phenotype: vacuoles in the VMA11-disrupted S. cerevisiae cells were not assembled with either subunit c or subunits a and b of the H(+)-ATPase, resulting in defects of the activity and in vivo vacuolar acidification.; Remark: vma11 of S. cerevisiae is also called TFP3.; Title: strong similarity to vacuolar H(+)-transporting ATPase chain c - Saccharomyces cerevisiae; See PMID 9030535; See PMID 1491234; See PMID 10825180; See PMID 1830311
An07g05090	Function: ROM1 of S. cerevisiae acts as GDP-GTP exchange protein (GEP) for the Rho1p small GTP-binding protein, which is e. g. required for bud formation.; Remark: other names for the ROM1 protein of S. cerevisiae are protein kinase C suppressor SKC1 or YGR070W.; Similarity: the predicted ORF shows strong similarity to several GDP/GTP exchange proteins, the strongest similarity is found to a predicted rho1 protein of S. pombe.; Title: strong similarity to GDP/GTP exchange protein Rom1 - Saccharomyces cerevisiae; See PMID 9759491
An07g05100	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Similarity: the predicted ORF is 336 amino acids longer than het-6 of N. crassa. Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Title: strong similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An07g05110	Function: members of the septin gene family are involved in cytokinesis and the organization of new growthcytokinesis; Title: strong similarity to septin aspA -Aspergillus nidulans; cytoskeleton; See PMID 9126618; See PMID 11238387
An07g05130	Remark: the ORF contains WD-repeats, which are usually present in the beta-subunit of G-proteins.; Title: strong similarity to hypothetical protein AAF54315.1 - Drosophila melanogaster
An07g05140	Function: U1 snRNP 70K proteins are bound to the stemloop I of the U1 small nuclear RNA contained in the U1 small nuclear ribonucleoprotein complex (U1 snRNP), which is involved in the splicing of pre-mRNA.; Similarity: the ORF show strong similarity to U1 snRNP 70K proteins from different species.; Title: strong similarity to 70K U1 small nuclear ribonucleoprotein - Drosophila melanogaster; nucleus; See PMID 10588732; See PMID 1692955
An07g05150	Function: LIC2 of R. norvegicus is a subunit of dynein, the cytoplasmic multi-subunit complex involved in retrograde organelle transport and some aspects of mitosis.; Remark: is also called LC53/55 or DNCLI2.; Title: strong similarity to dynein light intermediate chain 2 LIC-2 - Rattus norvegicus; cytoskeleton; See PMID 10047518; See PMID 10893222
An07g05160	Title: similarity to hypothetical protein C01B10.8 -Caenorhabditis elegans
An07g05180	Function: SAT4 of S. cerevisiae is involved in the regulation of cation uptake probably by activating the Trk1-Trk2 potassium transporter, which increase the influx of potassium and decrease indirectly the membrane potential.; Phenotype: SAT4 gene disruption in S. cerevisiae results in greater cation sensitivity, deficient potassium uptake, growth sensitivity to a variety of toxic cations,including lithium, sodium, calcium, tetramethylammonium,hygromycin B, and low pH; and increased uptake of methylammonium, an indicator of membrane potential.; Phenotype: overexpression of SAT4 (and HAL5) increases the tolerance of S. cerevisiae cells to sodium and lithium.; Remark: SAT4 of S. cerevisiae is also called HAL4.; Similarity: the ORF shows similarity to several protein kinases from different species with various cellular function.; Title: strong similarity to serine/threonine-specific protein kinase Hal4 -Saccharomyces cerevisiae; See PMID 10207057; See PMID 1767593
An07g05190	Remark: the ORF is questionable due to its short lenght of only 41 amino acids.; Title: questionable ORF
An07g05210	Function: acyl-CoA synthetases form carbon-oxygen bonds between carbon and sulfur residues.; Similarity: the ORF shows similarity to fatty acid acyl-CoA synthetases from several bacteria, which probably differ in their substrate specifity (e. g. long chain,medium chain fatty acids).; Title: strong similarity to long-chain-fatty-acid acyl-CoA ligase fenL - Bacillus subtilis; See PMID 9387222; See PMID 10438779
An07g05220	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 135 amino acids.; Title: questionable ORF
An07g05230	Title: strong similarity to hypothetical protein mlr4389 - Mesorhizobium loti
An07g05240	Similarity: the ORF shows also unspecific similarity to some glutamic acid-rich proteins.; Title: weak similarity to breast and ovarian cancer associated antigen protein sequence SEQ ID NO:674 from patent WO200055173-A1 - Homo sapiens
An07g05270	Remark: the ORF is questionable due to its short lenght of only 52 amino acids.; Title: questionable ORF
An07g05280	Function: pmus1 is an phosphomutase homolog required in addition to the MAL4 gene for constitutive maltase synthesis and utilization in cytoplasmic petite cells.; Phenotype: a high copy number of pmu1 in S. cerevisiae suppresses the temperature sensitivity of the tps2 (trehalose-6-phosphate phosphatase) negative mutant by reducing the levels of trehalose-6-phosphate.; Title: strong similarity to phosphomutase homolog Pmu1 - Saccharomyces cerevisiae; See PMID 7050624; See PMID 8913738
An07g05290	Remark: SPCC1739. 02c of S. pombe is only once reported to be the putative mitochondrial protein L22 (http://www. sanger. ac. uk/cgi-bin/yeastpub/GN_KW_search. p), but also the ORF shows weak similarity to ribosomal protein L22 of T. maritima.; Title: similarity to hypothetical mitochondrial ribosomal protein - Schizosaccharomyces pombe
An07g05350	Function: Prp24 of S. cerevisiae participates in both the formation and disassembly of the U4/U6 hybrid during splicing.; Remark: Prp24 of S. cerevisiae is also called YMR268C or YM815.; Remark: the homologues U6 snRNP protein in S. pombe is more similar to the ORF than the S. cerevisiae protein (especially with the lenght of 1014 amino acids).; Similarity: the similarity of the ORF to U6 snRNP protein PRP24 of S. cerevisiae is restricted to its C-terminal part, starting with amino acid 657 of the ORF.; Title: strong similarity to U6 snRNP splicing factor Prp24 - Saccharomyces cerevisiae; nucleus
An07g05370	Remark: the correct name for the hypothetical protein Y105C5B. g of C. elegans is probably Y105C5B. 9.; Title: strong similarity to hypothetical protein Y105C5B.9 - Caenorhabditis elegans
An07g05380	Function: WD-repeats are usually present in the beta-subunit (beta-transducin) of G proteins, which mediate signal transduction.; Function: the het-e-1 gene of the fungus P. anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Similarity: the similarity of the ORF to het-e-1 of P. anserina is restricte dto a region containing a repeated Trp-Asp motif (also called WD repeat).; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10322433
An07g05390	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g05410	Similarity: the similarity of the ORF to SPBC83. 18c of S. pombe is restricted to the N-terminal part of the ORF (ending around amino acid 220), which shows homology to a C2 domain, that is often but not always involved in calcium-dependent phospholipid binding.; Title: similarity to hypothetical protein SPBC83.18c - Schizosaccharomyces pombe
An07g05420	Remark: the ORF is questionable due to the presence of only one single exon and its short lenght of only 111 amino acids.; Title: questionable ORF
An07g05430	Similarity: the ORF shows similarity to several lipases (EC 3. 1. 1) from different species.; Similarity: the similarity of the ORF to hsl of H. sapiens is restricted to the inner part of both molecules.; Title: similarity to triacylglycerol lipase hsl -Homo sapiens; See PMID 8506334
An07g05440	Function: maleylacetate reductases contribute to the bacterial catabolism of some usual aromatic compounds like quinol or resorcinol and also to the degradation of aromatic compounds carrying unusual substituents, such as halogen atoms or nitro groups.; Similarity: the ORF shows similarity to several short-chain dehydrogenase/reductase from different species and with various function, most of which are 3-oxoacyl-(acyl carrier protein) reductases, that are involved in fatty acid biosynthesis (EC 1. 1. 1. 100).; Title: strong similarity to maleylacetate reductase macA - Rhodococcus opacus
An07g05460	Title: strong similarity to hypothetical protein CAE47856.1 - Aspergillus fumigatus
An07g05470	Remark: the predicted ORF is questionable due to its lenght of only 43 amino acids.; Title: questionable ORF
An07g05480	Title: weak similarity to polypeptide SEQ ID NO:30390 from patent WO200171042-A2 - Drosophila melanogaster
An07g05490	Function: the expression of spoVK in mother cells from B. subtilis is necessary for the completion of spore development.; Phenotype: mutations in spoVK of B. subtilis block the sporulation at a late stage.; Remark: spoVK of B. subtilis is also called spoVJ and belongs to the cbxx/cfxq superfamily, which members habour conserved sequence motifs.; Similarity: the predicted ORF shows similarity to sporulation specific proteins of different bacteria.; Title: strong similarity to stage V sporulation protein spoVK - Bacillus subtilis; See PMID 2514336; See PMID 6405008; See PMID 1732196; See PMID 1787791
An07g05500	Function: ctr3 of S. cerevisiae is a component of a trimeric high affinity copper permease, which functions in cooper uptake.; Phenotype: the null mutant of ctr3 from S. cerevisiae grows slower than wild-type under conditons of copper limitation on non-fermentable carbon source.; Remark: ctr3 of S. cerevisiae is also called YLR411W.; Remark: the predicted ORF is N-terminally truncated due to contig border.; Repression: ctr3 of S. cerevisiae is repressed by copper and activated by copper starvation.; Title: strong similarity to copper permease component Ctr3 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 8756349; See PMID 9188496; See PMID 10924521
An07g05510	Catalytic activity: fre3 of S. cerevisiae catalyses NADH + 2 Fe3(+) = NAD(+) + 2 Fe2(+).; Function: fre3 of S. cerevisiae is a siderophore-iron reductase, which is required for the reduction and uptake of ferrioxamine B-iron and for growth on ferrioxamine B, ferrichrome, triacetylfusarinine C, and rhodotorulic acid in the absence of fre1 and fre2.; Induction: fre3 of S. cerevisiae is metalloregulated by ion and its transcription is controlled through the aft1 transcription factor.; Remark: fre3 of S. cerevisiae is also called O6754 or YOR381w.; Title: strong similarity to ferric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9726978; See PMID 10341420; See PMID 11120744
An07g05520	Catalytic activity: omtB of A. parasiticus converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: omtB of A. parasiticus is involved in the biosynthesis of the secondary metabolite and mycotoxin aflatoxin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361; See PMID 9532734
An07g05530	Remark: the predicted ORF is short in length, only 52 amino acids, and exhibits suboptimal exon-intron structure.; Title: weak similarity to hypothetical protein encoded by An18g02690 - Aspergillus niger
An07g05540	Remark: the predicted ORF is questionable due to its lenght of only 55 amino acids and its suboptimal exon-intron structure.; Title: questionable ORF
An07g05550	Remark: the predicted ORF shows also similarities to several different proteins due to the presence of an internal poly-glutamic acid stretch.; Title: weak similarity to signal peptide containing protein HSPP-56 SEQ ID NO:56 from patent WO200000610-A2 -Homo sapiens
An07g05570	Catalytic activity: chs1 of A. nidulans catalyzes the alpha-1,4-glycosylation of chitin by UDP-N-acetyl-D-glucosamine producing elongated chitin and UDP.; Function: chs1 of A. nidulans is necessary for the synthesis of the cell wall polysaccharide chitin.; Phenotype: deletion mutants of chs1 from A. nidulans exhibited growth defects on media supplemented with sodium dodecyl sulfate (SDS), high concentration of salts,chitin-binding dyes, or chitin synthase competitive inhibitors, suggesting loss of integrity of the hyphal wall.; Title: strong similarity to chitin synthase chs1 -Aspergillus nidulans; See PMID 10731706
An07g05580	Remark: the predicted ORF is questionable due to its lenght of only 72 amino acids.; Title: questionable ORF
An07g05590	Remark: the predicted ORF is questionable due to its lenght of only 30 amino acids.; Title: questionable ORF
An07g05600	Catalytic activity: protein tyrosine phosphatases convert protein tyrosine phosphate + H2O = protein tyrosine + orthophoshate.; Function: stp1 of S. pombe may contribute to the dephosphorylation of tyrosine 15 from Cdc2, thereby activating Cdc2/cyclin B kinase, which then brings about mitosis.; Remark: stp1 of S. pombe is also called SPAC926. 01C or SPAC1071. 12c.; Similarity: the ORF shows similarity to several protein-tyrosine-phosphatases from different species with various cellular function.; Title: strong similarity to small protein-tyrosine-phosphatase stp1p - Schizosaccharomyces pombe
An07g05610	Function: cat5 of S. cerevisiae is involved in monoxygenase steps in the synthesis of ubiquinone (coenzyme Q) by an unknown mechanism and is a central metabolic regulator required for the derepression of pck1 (phosphoenolpyruvate carboxykinase), and thereby gluconeogenesis.; Phenotype: deletion of cat5 of S. cerevisiae causes a complete loss of glucose derepression affecting gluconeogenic key enzymes.; Remark: cat5 of S. cerevisiae is also called O3284,YOR125c or YOR3284c and belongs to the coq7 protein family.; Title: strong similarity to ubiquinone biosynthesis protein Cat5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8621692; See PMID 9266513
An07g05620	Function: rtf1 of S. cerevisiae is involved in the control of transcription elongation by regulating the DNA-binding properties of spt15, the TATA box-binding protein, and the relative activities of different TATA elements.; Phenotype: the null mutant of rft1 from S. cerevisiae is viable and can suppress TATA box-binding protein mutants (spt15) in an allele-specific fashion.; Remark: rtf1 of S. cerevisiae is also called YGZ4_YEAST, YGL244W or HRA458.; Title: strong similarity to transcription elongation factor Rtf1 - Saccharomyces cerevisiae; nucleus; See PMID 11014804; See PMID 9234706
An07g05630	Similarity: the predicted ORF shows weak similarity to glutamic acid-rich proteins due to its relatively high glutamic acid content.; Title: strong similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe
An07g05640	Function: nirA of A. nidulans encodes a transcription factor with a GAL4-type zinc finger domain.; Function: nirA of A. nidulans is a pathway-specific regulatory gene of nitrate assimilation.; Phenotype: mutations in nirA of A. nidulans affect the transcription levels of niiA and niaD (a nitrite and a nitrate reductase, respectively).; Remark: an alternate name for nitrate assimilation regulatory protein nirA is transcription factor nirA.; Similarity: the predicted ORF is 200 amino acids shorter at its c-terminal end than nirA of A. nidulans.; Similarity: the predicted ORF overlaps with A. niger EST SEQ ID NO:4207 PATENTDNA:F11684.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 347305; See PMID 1538701; See PMID 1990284
An07g05650	Catalytic activity: salicylate hydroxylase of P. putida converts salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2 with FAD as cofactor.; Function: salicylate hydroxylase nahG of P. putida is a FAD-dependent monooxygenase enzyme, which catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Similarity: the predicted ORF shows similarities to salicylate hydroxylases of several species.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida
An07g05660	Function: based on the similarity to fibroin or proteins involved in hyphal formation, it is assummed that the predicted ORF encodes a protein playing a role in filamentous growth of A. niger.; Similarity: due to the presence of glycine/serine/proline-rich repeat stretches in the N-terminal part, the predicted ORF shows similarity to extracellular matrix protein family members or to cell wall-attached proteins which contain similar repeats.; Title: similarity to hypothetical protein EAA64430.1 - Aspergillus nidulans
An07g05670	Remark: due to the fact that the predicted ORF has no predicted membrane regions, it is assummed that the A. niger protein is in contrast to the homologues S. cerevisiae proteins YOR389w and YPL277c not membrane-associated.; Title: strong similarity to hypothetical membrane protein YOR389w - Saccharomyces cerevisiae
An07g05680	Remark: the predicted ORF is questionable due to the presence of an unusual intron-exon structure and its lenght of only 69 amino acids.; Title: questionable ORF
An07g05690	Function: YLL057c of S. cerevisiae is involved in sulfonate catabolism by functioning as an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, which uses isethionate and taurocholate as best natural substrates.; Induction: the transcription of YLL057c from S. cerevisiae has been shown to increase more than 10-fold under sulphate starvation conditions.; Phenotype: disruption of YLL057c in S. cerevisiae negatively affects the use of isethionate and taurine as sulfur sources.; Remark: YLL057c is also called L0572.; Similarity: the predicted ORF shows similarity to dioxygenases, especially taurine dioxygenases, from several species.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942
An07g05700	Remark: the predicted ORF is questionable due to the presence of an unusual intron-exon structure.; Title: questionable ORF
An07g05730	Function: srpk2 of M. musculus is involved in the regulation of pre-mRNA splicing by serine/arginine-rich proteins (SR proteins).; Function: srpk2 of M. musculus regulates the disassembly of SR protein-containing nuclear speckles (storage compartments) by phosphorylation and therefore putatively controls the activity of splicing.; Title: strong similarity to SR protein-specific kinase srpk2 - Mus musculus; nucleus; See PMID 9472028
An07g05740	Similarity: the predicted ORF shows similarity to several puatative esterases/lipases from different species.; Title: strong similarity to hypothetical abhydrolase SPAC22H12.03 - Schizosaccharomyces pombe
An07g05750	Function: mct1 of C. griseus is a monocarboxylate transporter responsible for the uptake of lactate and pyruvate.; Remark: a Phe to Cys substitution in mct1 of C. griseus converts it to mev, a mevalonate transporter (PIRA44458).; Similarity: the predicted ORF shows strong similarity to several putative monocarboxylate transporters from different species, e. g. YNL125c of S. cerevisiae is a homologue to MCT1 and MCT2.; Title: strong similarity to monocarboxylate transporter 1 mct1 - Cricetulus griseus; plasma membrane
An07g05760	Title: similarity to hypothetical protein YMR130w -Saccharomyces cerevisiae
An07g05770	Remark: the predicted ORF partially overlaps with EMBLEST:BE759038 from A. niger.; Similarity: additionally, the predicted ORF overlaps with EMBLEST:BE760450, EMBLEST:BE760893 and PATENTDNA:F11689 EST SEQ ID NO:4212 from A. niger.; Title: strong similarity to EST an_3321 -Aspergillus niger
An07g05790	Function: sgd1 of S. cerevisiae is involved osmoregulatory responses resulting in glycerol production (HOG pathway).; Phenotype: an increased dosage of sgd1 in S. cerevisiae partially suppresses the osmosensitivity of mutants that are defective in the HOG mitogen-activated protein kinase pathway by re-establishing transcriptional control of the osmostress-induced expression of the NAD(+)-dependent glycerol 3-phosphate dehydrogenase.; Phenotype: the null mutant of sgd1 from S. cerevisiae is inviable.; Remark: alternate names for sgd1 are L8300. 12 and YLR336c.; Title: strong similarity to osmoregulatory protein Sgd1 - Saccharomyces cerevisiae; nucleus; See PMID 11042259
An07g05800	Function: srp14 of C. familiaris is involved in the targeting of secretory proteins to the rough endoplasmic reticulum membrane.; Function: srp14 together with srp9 are necessary for binding to the alu portion of SRP RNA, which together constitute the elongation domain of the six subunits-containing signal recognition particle (SRP).; Similarity: the similarity of the predicted ORF to srp14 of several species is restricted to the C-terminal part of srp14, starting in the region between amino acid 30 to 60.; Title: similarity to signal recognition particle protein srp14 - Canis lupus; See PMID 9233785
An07g05810	Similarity: the predicted ORF partially overlaps with A. niger EST EMBLEST:BE758923.; Title: similarity to hypothetical protein CAD60772.1 - Podospora anserina
An07g05820	Function: usgS of A. nidulans interferes with the transcription of its 3' end gene formidase fmdS, which has a putative homologue on ORF 82ck (see usgS of A. nidulans).; Title: strong similarity to hypothetical transmembrane protein usgS - Aspergillus nidulans; See PMID 11139496
An07g05830	Catalytic activity: fmdS of A. nidulans hydrolyses formamide with the production of ammonia.; Catalytic activity: formamide + H2O = formate + NH3.; Function: fmdS of A. nidulans is involved in the utilization of formamide as nitrogen source.; Induction: the 5' upstream gene of fmdS in A. nidulans interferes with fmdS transcription, resulting in a strong dependence on AreA activation for expression.; Induction: the expression of fmdS of A. nidulans is primarily regulated via AreA, a zinc finger transcription factor, which is the major nitrogen regulatory protein in A. nidulans.; Remark: like in A. nidulans, a gene (ORF 84ck) is located directly 5' to this ORF, which putatively encodes a regulatory transmembrane protein.; Remark: the relative position of the fmdS gene to the usgS gene, like in A. nidulans, might be essential for normal regulation of fmdS.; Title: strong similarity to formamidase fmdS -Aspergillus nidulans; See PMID 11139496
An07g05840	Function: (see ORF 50wg) hol1 of S. cerevisiae is involved in the uptake of several cations and histidinol,the biosynthetic precursor to histidine.; Phenotype: additional hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Similarity: strong similarity to ORF 50wg, another major facilitator protein.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10436161; See PMID 2405251
An07g05850	Remark: the predicted ORf is questionable due to its unusally long introns.; Title: questionable ORF
An07g05870	Remark: the predicted ORF is questionable due to the unusally short second exon.; Title: questionable ORF
An07g05880	Function: hol1 of S. cerevisiae is involved in the uptake of several cations and histidinol, the biosynthetic precursor to histidine.; Phenotype: additionally, hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Remark: hol1 is also called YNR055C or N3494 and belongs to the major facilitator family (drug resistance translocase family).; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10436161; See PMID 2405251
An07g05890	Remark: the predicted ORF is questionable due to its unusal exon-intron structure and proximity to the adjacent ORFs.; Title: questionable ORF
An07g05900	Catalytic activity: fructosyl amino acid oxidases act on the CH-NH group of donors with oxygen as acceptor under formation of hydrogen peroxide and glucosone.; Function: faoA of A. terreus is an FAD-binding oxidoreductase, which deglycates glycated model compounds like N-epsilon-fructosyl N-sigma-Z-lysine and N-fructosyl valine, oxidatively into free fructosamine.; Remark: fructosyl amino acid oxidase is often used as an enzyme for the determination of glycated Amadori products in blood samples from diabetic patients.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 8534116; See PMID 9139700
An07g05920	Function: cypD of B. taurus accelerates folding of proteins by acting as a PPIase, which possesses cis-trans isomerase activity on proline imidic peptide bonds in oligopeptides.; Remark: cyclophilins are the intracellular receptors for the immunosuppressive, anti-fungal drug cyclosporin A.; Remark: cypD of B. taurus is also called ppid, cyp40 or erbc.; Remark: the predicted ORF partially overlaps with A. niger EST AN05D12.; Similarity: the predicted ORF shows similarity to proteins from different species, that all belong to the cyclophilin superfamily and show peptidylprolyl isomerase activity (named PPIases or rotamases).; Title: strong similarity to estrogen receptor-binding cyclophilin cypD - Bos primigenius taurus; See PMID 8509368; See PMID 1530635; See PMID 1544925; See PMID 1825312
An07g05930	Function: D-Tyr-tRNA(Tyr)deacylase dtd1 of S. cerevisiae recycles misaminoacylated D-Tyr-tRNAn(Tyr), a process, which inhibits the accumulation of d-aminoacyl-tRNA molecules and is therefore important for cell rescue.; Phenotype: overexpression of the DTD1 gene in S. cerevisiae increased D-Tyr-tRNA(Tyr) deacylase activity.; Phenotype: upon disruption of the dtd1 chromosomal gene in S. cerevisiae, deacylase activity was decreased by more than 90%, and the sensitivity to D-tyrosine of the growth of S. cerevisiae was exacerbated.; Repression: in S. cerevisiae L-tyrosine auxotrophs,DTD1-like genes are systematically absent.; Similarity: the predicted ORF is 41 amino acids longer at the C-terminus than dtd1 of S. cerevisiae.; Title: strong similarity to D-Tyr-tRNA deacylase Dtd1 - Saccharomyces cerevisiae; See PMID 10766779; See PMID 10918062
An07g05940	Function: not3 of H. sapiens is part of the global negative regulator complex of RNA polymerase II transcription, consisting of the four NOT proteins, CCR4 and CALIF.; Title: strong similarity to transcription regulator not3 - Homo sapiens; nucleus; See PMID 10637334
An07g05950	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g05960	Function: msn2 of S. cerevisiae together with msn4 is facilitating a transcriptional response of the yeast to cellular stress situations, e. g. osmotic shock by inducing subsets of high osmolarity glycerol pathway-dependent genes.; Title: similarity to finger protein Msn2 -Saccharomyces cerevisiae; See PMID 10722658; See PMID 11292860
An07g05970	Function: ankyrins are involved in cell adhesion and protein targeting by attaching integral membrane proteins to cytoskeletal elements, e. g. by binding to Na/K-ATPase or to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Title: strong similarity to ankyrin Ank2 - Homo sapiens; See PMID 8253844; See PMID 8557748; See PMID 11427698
An07g05980	Function: G22P2 of H. sapiens is a ATP-dependent DNA unwinding enzyme, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.; Remark: is also called lupus Ku autoantigen protein P86 (KU86), KU80, thyroid-lupus autoantigen (TLAA), CTC box binding factor 85 KDa subunit (CTCBF), CTC85, nuclear factor IV or DNA-repair protein XRCC5.; Similarity: G22P2 of H. sapiens was found to be identical to the previously identified Ku autoantigen recognized by the sera of scleroderma and lupus erythematosus patients.; Title: strong similarity to ATP-dependent DNA helicase II 86 KD subunit G22P2 - Homo sapiens; nucleus; See PMID 2760028
An07g05990	Function: target SNAREs (t-SNAREs) are involved in membrane-fusion processes of exo-/endocytosis, where they act as a complex localized on the target membrane.; Phenotype: U. maydis yup1 mutants are temperature-sensitive and show defects in the polar distribution of cell wall components as well as abnormal morphology.; Similarity: the ORF shows some similarity to other syntaxin-like endosomal SNAREs from different species.; Similarity: the similarity of the ORF to tSNARE yup1 of U. maydis is locally high in its C-terminal part,starting with amino acid 429.; Title: similarity to endosomal t-SNARE yup1 -Ustilago maydis; See PMID 10790364
An07g06000	Catalytic activity: aspartate--tRNA ligases (= aspartyl-tRNA synthetases) facilitate the connection of L-aspartate with its respective tRNA bei catalyzing ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp).; Remark: dps1 of S. cerevisiae is also called APS1,APS, YLL018C OR L1295.; Title: strong similarity to cytosolic aspartate--tRNA ligase Dps1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3513127; See PMID 3902099; See PMID 2021621; See PMID 2047877
An07g06010	Similarity: the ORF shows strong similarity to a postulated phosphatidyl synthase of S. pombe.; Title: strong similarity to hypothetical protein YKR070w - Saccharomyces cerevisiae
An07g06020	Title: strong similarity to hypothetical protein YDR306c - Saccharomyces cerevisiae
An07g06030	Function: the coatomer complex is involved in the targeting of proteins via the Golgi and retrograde Golgi to ER transport.; Function: the gamma-COP subunit of the coatomer is believed to mediate the binding to the cytoplasmic dilysine motifs of membrane proteins.; Title: strong similarity to coatomer gamma subunit 2 copg2 - Homo sapiens; See PMID 10874328; See PMID 10995575; See PMID 11018518
An07g06040	Function: phosducins are known to bind G protein betagamma subunits in vitro, and are postulated to regulate their signaling function in vivo.; Function: plp2 of S. cerevisiae putatively acts as an inhibitor of G-protein GTPase activity, which results in selective regulation of early signaling events following pheromone stimulation and has an essential role in cell growth independent of its regulatory role in cell signaling.; Similarity: the ORF overlaps with A. niger EST an_3248 database entry EMBLEST:BE758982.; Title: strong similarity to phosducin homolog Plp2 -Saccharomyces cerevisiae; See PMID 10371466; See PMID 10749875
An07g06050	Remark: originally, the name yap3 was used for yeast aspartyl protease 3, which was renamed in yps1.; Remark: yap3 of S. cerevisiae binds most efficiently to TTACTAA, a sequence that differs at position +/-2 from the optimal AP-1 site (TGACTCA).; Similarity: the similarity of the ORF to transcription factors is locally high in the specific DNA-binding region containing a bZIP (basic-leucine zipper) motive, which is encoded by amino acid 126 to 142 of the ORF.; Title: similarity to bZIP transcription factor Yap3 - Saccharomyces cerevisiae; See PMID 9090053; See PMID 9372930
An07g06070	Remark: the ORF has a suboptimal intron-exon structure and shows only unspecific similarity to lysine-rich proteins.
An07g06080	Function: hhp1 of S. pombe is a casein kinase,specific for serine/threonine residues, which is involved in the regulation of DNA repair.; Phenotype: S. pombe strains lacking either or both hhp activities (hhp1 or hhp2) reveal differences in their ability to withstand DNA lesions caused by either methyl methanesulfonate (MMS) or gamma-rays which correlate with their ability to repair DNA strand breaks caused by these agents.; Similarity: the similarity to casein kinases from different species is high in the N-terminal part with protein kinase specific motivs, but lower in the C-terminal region, where glycine/proline rich stretches are present in casein kinases.; Title: strong similarity to casein kinase-1 homolog hhp1p - Schizosaccharomyces pombe
An07g06090	Similarity: the ORF shows similarity to A. niger ESTs an_3627 database entry EMBLEST:BE759275 and an_2936 entry EMBLEST:BE759984.; Title: strong similarity to EST an_3627 -Aspergillus niger
An07g06100	Function: tea1 of S. pombe is involved in maintaining cell integrity and directs the growth machinery by acting as an end marker at the microtubulin-associated cell poles.; Repression: tea1 of S. pombe is down-regulated in cells treated with pheromone that grow toward a mating partner and no longer maintain their ends exactly opposed.; Title: strong similarity to cell polarity protein tea1p - Schizosaccharomyces pombe; See PMID 9200612
An07g06130	Remark: the hypothetical protein YHR186c of S. cerevisiae is a putative membrane protein, but for the ORF no membrane region is predicted.; Title: strong similarity to hypothetical guanine nucleotide binding protein - Schizosaccharomyces pombe
An07g06140	Title: weak similarity to apoptosis associated protein YDR442W from patent WO200102550-A2 - Saccharomyces cerevisiae
An07g06150	Catalytic activity: erg7 of S. cerevisiae converts (S)-2,3-epoxysqualene <=> lanosterol.; Function: erg7 of S. cerevisiae catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi (gene ERG7).; Remark: is also called OSC or YHR07.; Title: strong similarity to lanosterol synthase erg7p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 8604986
An07g06170	Similarity: the ORF shows similarity to several glycine-rich proteins.
An07g06180	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g06190	Similarity: the ORF shows similarity to some proteins wird RING finger homology.; Title: similarity to hypothetical related to COP1-interacting protein CIP8 - Neurospora crassa
An07g06200	Function: ccr4 of S. cerevisiae as a component of the major cytoplasmic mRNA deadenylase is required for the expression of a number of genes involved in nonfermentative growth, e. g. the control of ADH2 (glucose-repressible alcohol dehydrogenase) gene expression.; Induction: ccr4 of S. cerevisiae is, in contrast to that of many other activators, glucose regulated.; Phenotype: disruption of ccr4 in S. cerevisiae cells resulted in reduced levels of ADH2 expression under both glucose and ethanol growth conditions and in temperature sensitive growth on nonfermentative medium.; Remark: ccr4 of S. cerevisiae is also called YAL021C, FUN27 or nut21.; Similarity: the ORF shows only local similarity to ccr4 of S. cerevisiae, which is high in the inner leucin-rich region (amino acid 232 to 312) of the ORF.; Title: similarity to glucose-repressible transcriptional effector Ccr4 - Saccharomyces cerevisiae; See PMID 6392016; See PMID 8007957; See PMID 11239395; See PMID 2407614
An07g06220	Remark: the ORF is questionable due to its short lenght of only 95 amino acids.; Title: questionable ORF
An07g06240	Function: sti1 of S. cerevisiae is a ferrioxamine B permease involved in siderophore (microbial iron chelators) iron transport.; Phenotype: S. cerevisiae cells with a deleted sti1 gene are unable to take up ferrioxamine B.; Remark: sit1 of S. cerevisiae is also called ARN3 or YEL065W.; Similarity: the ORF shows similarity to several major facilitator protein homologs from different species and with various specificities.; Title: strong similarity to ferrioxamine B permease Sit1 - Saccharomyces cerevisiae; endosome; See PMID 9884238; See PMID 10637361; See PMID 10744769; See PMID 11158346
An07g06270	Title: similarity to hypothetical protein encoded by An04g09900 - Aspergillus niger
An07g06280	Pathway: maiA of A. nidulans is a structural gene of the phenylalanine catabolic pathway.; Similarity: the MaiA protein and this protein show strong amino acid sequence identity to glutathione S-transferases.; Title: strong similarity to maleylacetoacetate isomerase maiA - Aspergillus nidulans; See PMID 9417084
An07g06300	Similarity: shows strong similarity to several fungal transporter proteins.; Title: strong similarity to member of the hexose transporter family of the major facilitator superfamily Hxt16 - Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 9348664
An07g06310	Catalytic activity: L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans T-100 that showed an ability to convert D-sorbitol to 2-keto-L-gulonate.; Function: high-level production from D-sorbitol to 2-KLGA (130 mg/ml) was achieved by simple fermentation of the recombinant Gluconobacter.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans; See PMID 9023923
An07g06330	Title: strong similarity to hypothetical protein EAA58260.1 - Aspergillus nidulans
An07g06340	Function: the patented proteins may be used to stimulate the growth and motility of keratinocytes, to inhibit the growth of cancer cells, to modulate angiogenesis and tumour vascularisation, to modulate skin inflammation, to modulate epithelial cell growth and to inhibit binding of HIV-1 to leukocytes.; Localization: contains no transmembranal domain,therefore not localized in membranes.; Remark: the patented sequences derived from rat dermal papilla, human keratinocytes and neonatal foreskin fibroblasts, and mouse embryonic skin, keratinocyte stem cells and transit amplifying cells.; Title: similarity to skin cell transmembrane protein from patent WO9955865-A1 - Rattus sp.
An07g06350	Remark: FHA is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Remark: the ORF is truncated due to border of contig.; Similarity: shows only partial similarity to aminoterminal part of S. pombe protein containing the FHA (Forkhead-associated) domain.; Title: similarity to hypothetical forkhead nuclear signaling protein SPBC3H7.13 - Schizosaccharomyces pombe [truncated ORF]
An07g06360	Title: weak similarity to zinc finger II protein from patent WO200037629-A2 - Aspergillus terreus
An07g06370	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to protease type 2 encoded by the gene iga1 - Haemophilus influenzae
An07g06380	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to neurofilament triplet M protein - Mus musculus
An07g06390	Similarity: show similarity to N-terminal fifth of An15g04750.; Title: weak similarity to hypothetical protein encoded by An15g04750 - Aspergillus niger
An07g06400	Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Cofactor: copper and topequinone.; Complex: AO-I exists as a homodimer.; Induction: AO-I from A. niger is induced by N-butylamin.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: the AO-I aa sequence deviates significantly from the genomic sequence and therefore shows that two isoenzymes exist AO-I and AO-II.; Similarity: AO-I from A. niger belongs to a group of enzymes including those oxidizing primary monoamines,diamines and histamine.; Similarity: AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; cell wall; See PMID 8620882; See PMID 10896215
An07g06420	Title: weak similarity to enhancer-binding protein C/EBP-delta - Mus musculus
An07g06430	Function: Monoglucosylated structures may be formed by reglucosylation of Man7-9GlcNAc2 by the UDP-Glc:glycoprotein glucosyltransferase gpt1 from S. pombe.; Induction: Synthesis of the gpt1 mRNA from S. pombe was induced 2- to 9-fold by conditions known to affect glycoprotein folding in the ER.; Phenotype: the S. pombe gpt1 mutant lacks UDP-Glc:glycoprotein glucosyltransferase.; Title: strong similarity to glycoprotein glucosyltransferase gpt1p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 8631292; See PMID 9813085
An07g06440	Function: the matched protein of patent JP09009966-A from Acremonium chrysogenum, is involved in the biosynthesis of cephalosporin C.; Remark: about the patent is no further information available.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [truncated ORF]
An07g06450	Function: the matched protein from A. chrysogenum is involved in the biosynthesis of cephalosporin C.; Remark: start codon is missing.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [truncated ORF]
An07g06460	Function: both enzymes from S. lactamdurans are required for cephem hydroxylation at C-7 and the transfer of the methyl group from S-adenosylmethionine to the 7-hydroxycephem intermediate.; Function: the C-7 hydroxycephem methyltransferase coupling protein from S. lactamdurans is encoded by ORF8 of a cephamycin biosynthetic enzyme gene cluster.; Function: the matched protein from S. lactamdurans acts as a coupling protein with the C-7 hydroxycephem methyltransferase, during the biosynthesis of cephamycin.; Remark: Nocardia lactamdurans = Streptomyces lactamdurans.; Title: similarity to C-7 hydroxycephem methyltransferase coupling protein from patent WO9529253-A1 - Streptomyces lactamdurans
An07g06470	Title: weak similarity to neurofibromatosis type 1 NF1 - Mus musculus
An07g06480	Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.; Function: recombinant cyp4F8 of H. sapiens oxygenated arachidonic acid to (18R)-hydroxyarachidonate.; Remark: belongs to the cytochrome P450 family.; Remark: cyp4F8 of H. sapiens is involved in prostaglandin synthesis.; Remark: the ORF shows similarity to several cytochromes.; Title: similarity to cytochrome 4F8 cyp4F8 - Homo sapiens; See PMID 10791960
An07g06490	Function: IDE of R. norvegicus degrades insulin,glucagon, and other polypeptides.; Remark: IDE of R. norvegicus has also been implicated in the clearance of beta amyloid peptides. Thus,the enzyme may also be a candidate for an alternative gene therapeutic approach to the treatment of Alzheimer's disease.; Remark: IDE of R. norvegicus is also called insulysin, insulinase, and insulin protease.; Title: strong similarity to insulin-degrading enzyme IDE - Rattus norvegicus; See PMID 11102481; See PMID 11235899
An07g06500	Function: SKY1 of S. cerevisiae, a serine/arginine-rich protein kinase, is a key regulator of polyamine transport and is involved in 3' splice site recognition upon interaction with Prp8 and Prp17/Slu4.; Similarity: the ORF is much shorter than SKY1 of S. cerevisiae (358 compared to 742 amin acids) and the similarity between the two proteins extends over a stretch of about 150 amino acids.; Title: similarity to SR protein kinase Sky1 -Saccharomyces cerevisiae; See PMID 11113192; See PMID 11565750; See PMID 11585720
An07g06510	Function: Rrp40 from S. cerevisiae is a component of the exosome complex responsible for 3' end processing and degradation of many RNA species.; Function: Rrp40 from S. cerevisiae is involved in rRNA processing.; Remark: the synonym for Rrp40 from S. cerevisiae is YOL142w.; Title: strong similarity to protein involved in ribosomal RNA processing Rrp40 - Saccharomyces cerevisiae; nucleus; See PMID 10465791; See PMID 9778798
An07g06520	Function: pdr13 of S. cerevisiae probably influences pleiotropic drug resistance by enhancing the function of the transcriptional regulatory protein Pdr1p, which regulates the expression of several multi-drug resistance transporter-encoding genes.; Similarity: the ORF shows simlarity to several hsp70 homologs with various substrate specificities.; Title: strong similarity to heat shock protein 70 homolog Pdr13 - Saccharomyces cerevisiae; See PMID 11395418; See PMID 9488429
An07g06530	Function: sur7 of S. cerevisiae probably acts in relation with rvs161 and rvs167, two proteins involved in budding and actin skeleton morphology.; Phenotype: when sur7 is overexpressed in S. cerevisiae it suppresses the reduced viability upon carbon starvation of the rvs167 mutant strain.; Remark: sur7 of S. cerevisiae is also called YML052W or YM9958. 11.; Similarity: the similarity to sur7 of S. cerevisiae is restricted to the N-terminal regions, ending with amino acid 189 of the ORF.; Title: strong similarity to multicopy suppressor Sur7 - Saccharomyces cerevisiae; See PMID 9219339
An07g06535	Title: strong similarity to hypothetical protein EAA60416.1 - Aspergillus nidulans
An07g06540	Similarity: the predicted ORF is twice as long as the putative S. pombe protein.; Title: strong similarity to hypothetical cytochrome c oxidase assembly protein SPAC1420.04c -Schizosaccharomyces pombe
An07g06550	Title: strong similarity to hypothetical protein EAA60414.1 - Aspergillus nidulans
An07g06560	Function: mitochondrial ATP synthase chain j of S. pombe is one of the chains of the non-enzymatic component (CF(0) subunit) of the mitochondrial ATPase complex.; Similarity: the ORF overlaps with A: niger ESTs EMBLEST:BE759173 and EMBLEST:BE760809.; Title: strong similarity to mitochondrial ATP synthase chain j - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 9867807
An07g06570	Remark: mrp2 of S. cerevisiae is also called P9325. 7 or YPR166c.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759438.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S14 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 770043; See PMID 8265368
An07g06580	Similarity: the predicted ORF is 112 amino acids longer than the hypothetical protein from S. pombe.; Title: similarity to hypothetical protein SPAC13G7.07 - Schizosaccharomyces pombe
An07g06590	Function: vph2 of S. cerevisiae is involved in vacuolar acidification probably by promoting the assembly of vacuolar H(+)-ATPase.; Phenotype: the null mutant of vph2 in S. cerevisiae is viable, zinc sensitive, defective in vacuolar acidification, calcium-sensitive and respiratory deficient.; Remark: vph2 of S. cerevisiae is also called vma12,cls1, YKL119c or YKL520.; Similarity: the similarity to vph2 of S. cerevisiae is locally high in the inner region of the ORF, which is homologues to the C-terminal part of vph2 (transmembrane domain), starting with amino acid 110.; Title: similarity to vacuolar H+-transporting ATPase assembly protein Vph2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8465604
An07g06600	Function: prefoldin is a heterohexameric chaperone protein able to bind specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it.; Phenotype: deletion of the pfd3 gene in S. cerevisiae results in impaired functions of the actin and tue actin and tubulin-based cytoskeleton.; Remark: synonyms for prefoldin subunit 3 pfd3 of H. sapiens are von Hippel-Lindau binding protein 1, VHL binding protein-1, VBP-1 and HIBBJ46.; Title: strong similarity to prefoldin subunit 3 pfd3 - Homo sapiens
An07g06610	Catalytic activity: UDP-glucose:sterol glucosyltransferases convert UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760047.; Title: strong similarity to UDP-glucose:sterol glucosyltransferase UGT51B1 - Pichia pastoris
An07g06630	Similarity: the predicted oRF shows similarity to proteins containing serine or lysine-rich stretches.
An07g06640	Similarity: the ORF shows also strong similarity to the homologues hypothetical protein in yeast, YLL035w of S. cerevisiae and the region with highest homology (around amino acid 300 to 440) is similar to the product of M. musculus neonate skin cDNA (clone:4632412I24) and a hypothetical protein T30N20_280 of A. thaliana (includes a small part of sequence block IPB001482B).; Title: strong similarity to hypothetical protein SPCC830.03 - Schizosaccharomyces pombe
An07g06650	Catalytic activity: 3-oxoacyl-acyl carrier protein reductases convert (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Catalytic activity: acetoacetyl-CoA reductases convert (R)-3-hydroxyacyl-CoA + NADP(+) <=> 3-oxoacyl-CoA + NADPH.; Function: 3-oxoacyl-acyl carrier protein reductases show preference for acyl-carrier protein derivatives over CoA derivatives as substrates.; Function: acetoacetyl-CoA reductases and 3-oxoacyl-acyl carrier protein reductases function in the distinct steps of the fatty-acid biosynthesis.; Remark: the predicted ORF is probably N-terminally truncated, the homology of the rest sequence to several oxidoreductases from bacteria is high and speaks in favour for an 130 to 140 longer N-terminus.; Similarity: the ORF shows similarity to acetoacetyl-CoA reductases and 3-oxoacyl-acyl carrier protein reductases from different species.; Title: similarity to acetoacetyl-CoA reductase phbB - Zoogloea ramigera [truncated ORF]
An07g06670	Similarity: because the predicted ORF is of a short length, 65 aa, the similarity extends only over the C-terminal region of An04g09660 of A. niger.; Title: strong similarity to hypothetical protein encoded by An04g09660 - Aspergillus niger
An07g06700	Similarity: the predicted ORF is 160 amino acids longer at the N-terminus than the N. crassa protein.; Title: similarity to hypothetical protein CAF05888.1 - Neurospora crassa
An07g06710	Remark: the ORF might be questionable due to its short lenght of only 84 amino acids.; Title: weak similarity to hypothetical protein AAM43672.1 - Dictyostelium discoideum
An07g06720	Title: similarity to hypothetical protein CAE76294.1 - Neurospora crassa
An07g06730	Complex: cut3/SMC4 of S. pombe is a subunit of the SMC (structural maintenance of chromosomes) complex. SMC and non-SMC subunits form the condensin complex, which has supercoiling activity.; Function: cut3/SMC4 of S. pombe is involved in chromosome condensation.; Similarity: the predicted protein shows strong similarity to cut3/SMC4 of S. pombe, human hCAP-C (chromosome-associated polypeptide-C) and related proteins from diverse eucaryotic species.; Title: strong similarity to cut3p -Schizosaccharomyces pombe; nucleus; See PMID 7957061; See PMID 9285594; See PMID 10485849
An07g06740	Title: strong similarity to hypothetical protein EAA60398.1 - Aspergillus nidulans
An07g06750	Function: Rat7 from S. cerevisiae may play a direct role in nucleocytoplasmic export of RNA.; Remark: Rat7 from S. cerevisiae is located at the nuclear rim in a punctate pattern characteristic of nucleoporins.; Remark: alternate names for Rat7 from S. cerevisiae are NUP158 and YIL115c.; Title: similarity to repeat-containing nucleoporin Rat7 - Saccharomyces cerevisiae; See PMID 7744966
An07g06760	Remark: a splice site was detected upstream of the START codon.; Remark: ribosomal protein S20 of S. cerevisiae is encoded by gene RPS20 also known as URP2 and YHL015W.; Similarity: belongs to the s10p family of ribosomal proteins; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S20 - Saccharomyces cerevisiae; cytoplasm; See PMID 8021936
An07g06770	Function: involved in gamma-linolenic acid synthesis; Title: strong similarity to delta-6 desaturase -Mucor rouxii; See PMID 11112411
An07g06780	Catalytic activity: D-mannose 1-phosphate = D-mannose 6-phosphate; Similarity: to other phosphoglucomutases and phosphomannomutases; Title: strong similarity to hypothetical phosphomannomutase homolog - Schizosaccharomyces pombe; See PMID 1903398
An07g06800	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181; See PMID 2363715
An07g06820	Remark: the unknown dehydrogenase from Xanthobacter is capable of complementation of Xanthobacter Py2 mutants in epoxyalkane degradation; Title: strong similarity to hypothetical dehydrogenase - Xanthobacter sp.
An07g06840	Catalytic activity: dihydrolipoamide + NAD(+) = lipoamide + NADH; Complex: LPD1 of S. cerevisiae exists as a homodimer linked by one disulfide bond.; Function: lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Localization: LPD1 of S. cerevisiae has a potential transit peptide targeting it to the mitochondrion.; Phenotype: a recessive mutation in the LPD1 gene of S. cerevisiae leads to an inability to utilize glycerol or acetate as a carbon source and also an inability to sporulate.; Remark: in S. cervisiae LPD1 is also known as HPD1 and YFL018C.; Similarity: belongs to the pyridine nucleotide-disulfide oxidoreductases class-I; Title: strong similarity to precursor of dihydrolipoamide dehydrogenase Lpd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6404748; See PMID 2821168; See PMID 3058861; See PMID 3279419; See PMID 3528755
An07g06860	Title: questionable ORF
An07g06880	Remark: disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transport protein Stl1 - Saccharomyces cerevisiae; See PMID 8076821
An07g06900	Title: similarity to hypothetical protein CAD70537.1 - Neurospora crassa
An07g06910	Title: similarity to hypothetical protein encoded by An01g09070 - Aspergillus niger
An07g06920	Title: similarity to hypothetical protein encoded by An07g06900 - Aspergillus niger
An07g06930	Title: questionable ORF
An07g06940	Title: similarity to hypothetical protein encoded by An03g00300 - Aspergillus niger
An07g06960	Title: similarity to hypothetical protein SMb20606 -Sinorhizobium meliloti
An07g06980	Catalytic activity: ATP-independent breakage of single-stranded DNA,followed by passage and rejoining; Function: reduces the number of supercoils in a highly negatively supercoiled DNA; Similarity: belongs to prokaryotic type I/III topoisomerase family; Title: strong similarity to DNA topoisomerase III -Schizosaccharomyces pombe
An07g06990	Title: strong similarity to hypothetical protein SPCC594.04c - Schizosaccharomyces pombe
An07g07000	Function: independent of its proteolytic function, a chaperone-like activity of the Yta10-12 complex is required for assembly of the membrane-associated ATP synthase.; Function: the S. cerevisiae homolog Yty12p is subunit of the mitochondrial Yta10-12 complex m-AAA protease, which mediates the degradation of nonassembled inner membrane proteins. in contrast to nucleotide-dependent complex formation and substrate binding, proteolysis of bound polypeptides depends on the hydrolysis of ATP and the metallopeptidase activity of both subunits.; Remark: YTA12 of S. cerevisiae is also called RCA1 or YMR089C.; Remark: mutations in YTA12 of S. cerevisiae cause a mitochondrial respiratory deficiency as a result of a pleotropic defect in assembly of the respiratory chain and ATPase complexes.; Title: strong similarity to mitochondrial m-AAA protease subunit Yta12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7929327; See PMID 11309190
An07g07010	Function: ribosomal protein L24 interacts with the 5. 8 S rRNA of S. cerevisiae.; Phenotype: S. cerevisiae mutants lacking L24 shows just 25% of the normal polyphenylalanine-synthesizing activity followed by a decrease in P-site binding,suggesting the possibility that protein L24 is involved in the kinetics of translation.; Title: strong similarity to hypothetical ribosomal protein of the large subunit L24 YLR009w - Saccharomyces cerevisiae; cytoplasm; See PMID 6337137; See PMID 10852723
An07g07020	Similarity: the ORF overlaps with A. niger EST EMBLEST:AN755.; Similarity: the ORF shows similarity to several proteins with a DNA-J motive, which is found in some heat-shock proteins.; Title: strong similarity to methylation-controlled DNAJ-like protein mcj - Homo sapiens; See PMID 11358853
An07g07030	Remark: the ORF is questionable due to its short lenght of only 113 amino acids.; Title: questionable ORF
An07g07040	Remark: the ORF is questionable due to its short lenght of only 80 amino acids.; Title: questionable ORF
An07g07050	Function: the facB gene of A. niger is probably a regulatory gene involved in acetamide and acetate utilisation.; Phenotype: deletion of the facB gene in A. niger confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: the ORF shows similarity to several zinc finger transcription regulator proteins from different species and with various functions.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720
An07g07060	Similarity: the ORF is 3200 amino acids shorter than the putative H. sapiens transcription factor.; Title: strong similarity to hypothetical protein EAA60885.1 - Aspergillus nidulans
An07g07070	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An07g07090	Title: strong similarity to hypothetical protein 17E5.330 - Neurospora crassa
An07g07100	Title: strong similarity to hypothetical protein YIL064w - Saccharomyces cerevisiae
An07g07110	Function: pmp1 of S. pombe has an essential function in Cl- homeostasis, cytokinesis and cell viability.; Function: pmp1 phosphatase dephosphorylates pmk1,the third MAP kinase in fission yeast, in vitro and in vivo, and is bound to pmk1 in vivo, strongly suggesting that pmp1 negatively regulates pmk1 MAP kinase by direct dephosphorylation.; Similarity: the ORF shows similarity to several dual specificity phosphatases from different species and with various function.; Title: strong similarity to dual-specificity phosphatase mp1p - Schizosaccharomyces pombe
An07g07120	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An07g07140	Remark: ORF 5'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.
An07g07150	Complex: five proteins interact with mCBP in the yeast two hybrid system; mouse y-box protein 1 (msy-1),y-box-binding protein, hnRNP-L, filamin and splicing factor 9G8.; Function: mouse CBP is a single-stranded nucleic acid binding protein implicated in RNA-metabolism.; Localization: mouse CBP is found predominantly in the nucleus with the exception of the nucleoli.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3405 and 2579 .; Title: strong similarity to single-stranded nucleic acid binding protein CBP - Mus musculus; nucleus; See PMID 8208614; See PMID 8871564
An07g07160	Catalytic activity: P. putida fdm catalyzes the dismutation of formaldehyde to form methanol and formic acid at the ratio of 1:1 in the absence of the exogenous electron acceptor, NAD(H).; Function: P. putida fdm is required for formaldehyde biodegradation.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1690 .; Similarity: the predicted A. niger protein shows strong similarity to several putative glutathione-dependent formaldehyde dehydrogenases.; Title: similarity to formaldehyde dismutase fdm -Pseudomonas putida; See PMID 7766017
An07g07170	Complex: in a two-hybrid screen D. melanogaster yippee was physically interacting with Hyalophora cecropia Hemolin, a bacteria-induced insect immunoglobulin, D. melanogster Rpn11, spen, yip2, 3, 4, 6 and 7.; Title: strong similarity to Yippee - Drosophila melanogaster; See PMID 11240639
An07g07180	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.
An07g07190	Title: strong similarity to polypeptide SEQ ID NO:41748 from patent WO200171042-A2 - Drosophila melanogaster
An07g07200	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An07g07210	Function: S. cerevisiae PEX15 is required for peroxisome biogenesis.; Localization: S. cerevisiae PEX15 is an integral peroxisomal membrane protein.; Remark: alternative names for S. cerevisiae PEX15 are PAS21 and YOL044w.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. cerevisiae PEX15,which is 800 aa shorter.; Similarity: the predicted A. niger protein shows similarity to several predicted serine/threonine kinases.; Title: similarity to peroxisome assembly factor Pex15 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; peroxisome; See PMID 9405362
An07g07220	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An07g07230	Title: weak similarity to sulfohydrolase II from patent WO200068395-A2 - Chondrus crispus
An07g07240	Complex: F-box proteins contain a carboxy-terminal domain that interacts with substrates and a 42-48 amino-acid F-box motif which binds to the protein Skp1, the linker to the core ubiquitin ligase composed of the proteins Cdc53/Cul1, Rbx1 (also called Hrt1 and Roc1) and the E2 ubiquitin-conjugating enzyme Cdc34.; Function: F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs, which function in phosphorylation-dependent ubiquitination.; Remark: the genome of S. cerevisiae contains 16 F-box proteins.; Similarity: similarity is from the central region of the predicted A. niger protein to human FBL3, which is 300 aa shorter.; Title: similarity to SCF ubiquitin ligase (E3) F-box subunit FBL3 - Homo sapiens; See PMID 10531037; See PMID 10945468
An07g07250	Title: similarity to hypothetical protein SPAC12G12.02 - Schizosaccharomyces pombe
An07g07260	Similarity: the predicted A. niger protein contains a WD40-repeat domain.; Title: similarity to polypeptide SEQ ID NO:2662 from patent WO200153312-A1 - Homo sapiens
An07g07270	Function: S. cerevisiae TPT is implicated in the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD.; Remark: the systematic name for S. cerevisiae TPT1 is YOL102c .; Title: similarity to tRNA 2-phosphotransferase Tpt1 - Saccharomyces cerevisiae; See PMID 9148937
An07g07280	Catalytic activity: Sphingomonas sp. dxnF efficiently cleaves hydroxyquinol, yielding maleylacetate,the ketoform of 3-hydroxy-cis,cis-muconate.; Function: Sphingomonas sp. dxnF is involved in the degradation pathways of dibenzo-p-dioxin and dibenzofuran.; Title: strong similarity to hydroxyquinol 1,2-dioxygenase dxnF - Sphingomonas sp.; See PMID 10348858
An07g07290	Function: R. opacus pcaL is involved in the degradation of aromatic compounds.; Similarity: R. opacus pcaL is a merged enzyme consisting of a N-terminal 3-oxoadipate enol-lactone hydrolase, homologue to pcaD and a C-terminal 4-carboxymuconolactone decarboxylase homologue to pcaC.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal,3-oxoadipate enol-lactone hydrolase activity containing,region of, which is 200 aa shorter.; Title: similarity to 3-oxoadipate enol-lactone hydrolase part of the dual specificity protein pcaL -Rhodococcus opacus; See PMID 9495744
An07g07300	Similarity: the predicted A. niger protein shows similarity to several predicted reductases/dehydrogenases.; Title: strong similarity to prostaglandin f(2alpha) synthase TbPGFS - Trypanosoma brucei; See PMID 11067881
An07g07310	Function: in S. cerevisiae dom34 and D. melanogaster pelo mutants progression through the G1 phase of the cell cycle is delayed, cells enter meiosis aberrantly, nuclear envelope breakdown and spindle formation do not occur. in S. cerevisiae, the ability to form pseudohyphae is significantly diminisehd.; Function: rescue of dom34 by high copy expression of ribosomal protein S30 suggest that Dom34p functions in protein translation to promote G1 progression and differentiation.; Similarity: D. melanogaster pelo is homologue of S. cerevisiae dom34 and is able to rescue the dom34 phenotype.; Title: strong similarity to cell cycle factor pelota - Drosophila melanogaster; See PMID 9584085; See PMID 7588080
An07g07320	Similarity: similarity is from the predicted A. niger protein to the central region of human INCENP, which is 600 aa longer.; Title: weak similarity to microtubule associated inner centromer protein INCENP - Homo sapiens; See PMID 11453556
An07g07340	Function: K. marxianus ERD2 encodes the K/H-DEL tetrapeptide receptor, required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway.; Golgi; Title: strong similarity to luminal ER-protein retention receptor ERD2 - Kluyveromyces marxianus; See PMID 2172835; See PMID 2194670; See PMID 2194671
An07g07350	Title: weak similarity to protein fragment 3780 from patent EP1033405-A2 - Arabidopsis thaliana
An07g07370	Similarity: the predicted A. niger protein shows similarity to several Myb DNA-binding domain containing proteins.; Title: weak similarity to PC-MYB2 - Arabidopsis thaliana; See PMID 10482656
An07g07380	Function: S. cerevisiae FCY2 is a purine-cytosine permease involved in the uptake of adenine, hypoxanthine and cytosine.; Title: strong similarity to cytosine/purine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 2191181
An07g07390	Remark: the exon-intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs AN06A04, AN06B04 and an_3468.; Title: strong similarity to subunit IV of cytochrome c oxidase Cox4 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3017950
An07g07400	Remark: ORF 5'truncated due to end of contig.; Similarity: mouse MCAP belongs to the BET subgroup of the bromodomain superfamily.; Title: weak similarity to mitotic chromosome associated MCAP - Mus musculus [truncated ORF]
An07g07410	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF [truncated ORF]
An07g07420	Function: human Prp8 protein is a component of both U2- and U12-dependent spliceosomes.; Similarity: Prp8p is the most highly conserved large nuclear protein known.; Title: strong similarity to splicing factor PRP8 -Homo sapiens; nucleus; See PMID 9547260; See PMID 9774689; See PMID 10411133
An07g07430	Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L34.b - Saccharomyces cerevisiae; cytoplasm
An07g07450	Similarity: shows similarity to forkhead containing transcription factors, but similarity is only in the forkhead domain.; Title: similarity to fork head protein Fkh1 -Saccharomyces cerevisiae; See PMID 12183363
An07g07460	Function: cactin of D. melanogaster is a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function.; Similarity: shows strong similarity to 500 C-terminal aminoacids of D. melano9gaster cactin.; Title: similarity to Rel pathway controlling protein cactin - Drosophila melanogaster; See PMID 10842059
An07g07470	Title: weak similarity to nucleolar phosphoprotein p130 - Homo sapiens
An07g07480	Title: similarity to polypeptide SEQ ID NO:4314 from patent WO200171042-A2 - Drosophila melanogaster
An07g07490	Title: similarity to EST an_3112 - Aspergillus niger
An07g07500	Function: HMT1 of Schizosaccharomyces pombe confers resistance to cadmium.; Similarity: shows strong similarity to several known and hypothetical ABC-transporter proteins with different specificities of different species.; Title: strong similarity to ABC-type vacuolar membrane protein hmt1p - Schizosaccharomyces pombe; See PMID 7876244
An07g07510	Title: strong similarity to hypothetical protein EAA60859.1 - Aspergillus nidulans
An07g07520	Catalytic activity: alkaline phosphates catalyzes the conversion of an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Function: Pho8p of S. cerevisiae dephosphorylates phosphopeptides.; Function: Pho8p of S. cerevisiae is a type II integral membrane protein with short N-terminal cytoplasmic tail.; Function: Pho8p of S. cerevisiae is a vacuolar repressible alkaline phosphatase.; Function: Pho8p of S. cerevisiae is anchored in the membrane by an N-terminal transmembrane domain which appear to be an uncleaved signal sequence.; Title: strong similarity to vacuolar alkaline phosphatase Pho8 - Saccharomyces cerevisiae; See PMID 8499492
An07g07530	Function: UTR2 (alias CRH2) of S. cerevsiae is involved in cell wall organization at different stages of the yeast life cycle.; Title: strong similarity to cell wall protein Utr2 -Saccharomyces cerevisiae; See PMID 10757808
An07g07560	Catalytic activity: peptide methionine sulfoxide reductase catalyzes the conversion of protein methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin.; Function: one of the known posttranslational modification of proteins is the oxidation of methionine residues to methionine sulfoxide; this oxidation can occur since a variety of reactive molecules that are by-products of aerobic metabolism such as the superoxide anion,hydrogen peroxide, hydroxyl radical, and hypochlorite ion are capable of causing this oxidation.; Function: peptide methionine sulfoxide reductase (EC 1. 8. 4. 6), has been detected in virtually all organisms examined, catalyzes the reduction of Met(O) residues in proteins to methionine; Function: peptide methionine sulfoxide reductase could have an important function in providing cells with a defense against oxidative stress.; Remark: the systematic genename of MXR1 of S. cerevsiae is YER042W.; Title: strong similarity to peptide methionine sulfoxide reductase Mxr1 - Saccharomyces cerevisiae; See PMID 10473395
An07g07570	Function: Kip3 of S. cerevisiae operates within the nucleus to assemble and elongate the bipolar spindle.; Function: in S. cerevisiae kinesin-related proteins are involved within the nucleus to assemble and elongate the bipolar spindle and on the cytoplasmic microtubules to effect spindle and nuclear positioning within the cell.; Localization: Kip3 of S. cerevisiae is located on the astral and central microtubules in the cytoplasm and is also present in the nucleus.; Remark: Kip3 of S. cerevisiae has a systematic name of YGL216W.; Similarity: shows similarity to the N-terminal,kinesin motor domain containing half of several kinesin-related proteins of different organisms.; Title: similarity to kinesin-related protein Kip3 -Saccharomyces cerevisiae; See PMID 9281581
An07g07590	Title: strong similarity to hypothetical protein EAA60854.1 - Aspergillus nidulans
An07g07600	Protein sequence is in conflict with the conceptual translation; Function: proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; such a domain is known to exist in the following proteins: prokaryotic catabolite gene activator protein (CAP), cAMP- and cGMP-dependent protein kinases (cAPK and cGPK), vertebrate cyclic nucleotide-gated ion-channels.; Remark: a possible sequencing error occured at position 70830 leading to a stop, 1 base has been removed.; Similarity: shows similarity to several cyclic nucleotide-gated channel proteins of different organisms,but the similarity is only restricted to the cyclic nucleotide-binding domain.; Title: similarity to protein SEQ ID NO:7729 from patent WO200253728-A2 - Candida albicans [putative sequencing error]; putative sequencing error
An07g07610	Remark: shows some similarity to several other F-box containing proteins of different organisms.; Title: similarity to leucine-rich repeats containing F-box protein FBL6 - Homo sapiens; See PMID 10531035; See PMID 10945468
An07g07620	Title: weak similarity to hypothetical protein CG3918 - Drosophila melanogaster
An07g07630	Function: Avenacinase of G. graminis detoxifies the triterpenoid oat root saponin avenacin A-1, and is essential for pathogenicity of G. graminis var. avenae to oats.; Similarity: shows also strong similarity to several known and hypothetical beta-glucosidases of different organisms.; Title: strong similarity to avenacinase -Gaeumannomyces graminis
An07g07640	Remark: blast matches are not significant.; Title: weak similarity to protein sequence #58 from patent WO200224865-A2 - Unclassified organism
An07g07650	Remark: blast matches are nopt significant.
An07g07660	Title: similarity to hypothetical protein SPCC24B10.12 - Schizosaccharomyces pombe
An07g07670	Title: similarity to hypothetical protein CG1287 -Drosophila melanogaster
An07g07690	Function: Y14 of X. laevis associates preferentially with mRNAs produced by splicing but not with pre-mRNAs,introns, or mRNAs produced from intronless cDNAs.; Function: Y14 of X. laevis associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs.; Function: Y14 of X. laevis is reported to define novel intermediates in the pathway of gene expression,postsplicing nuclear preexport mRNPs, and newly exported cytoplasmic mRNPs, whose composition is established by splicing.; Localization: Y14 of X. laevis is a predominantly nuclear nucleocytoplasmic shuttling protein.; Title: strong similarity to RNA-binding protein Y14 - Xenopus laevis; See PMID 11030346
An07g07700	Title: similarity to hypothetical glycosyl hydrolase BAC68337.1 - Streptomyces avermitilis
An07g07710	Title: weak similarity to signal peptidase I sip -Streptomyces lividans
An07g07740	Title: weak similarity to hypothetical protein HRIHFB2072 - Homo sapiens
An07g07760	Complex: the 14-3-3 proteins Rad24 and Rad25 physically interact with Chk1 in fission yeast.; Function: rad24 from S. pombe is required for the DNA damage checkpoint which ensures that DNA damage is repaired before mitosis is attempted. S. pombe rad24 null mutants enter mitosis prematurely.; Remark: apart from checkpoint control, the 14-3-3 family of proteins plays a key regulatory role in signal transduction, apoptotic, and nutrient-sensing pathways.; Similarity: the predicted A. niger protein shows strong similarity to DNA damage checkpoint protein rad24 from S. pombe, which belongs to the 14-3-3 protein family.; Title: strong similarity to DNA damage checkpoint protein rad24p - Schizosaccharomyces pombe; See PMID 10090724; See PMID 11152955; See PMID 8036497
An07g07770	Title: weak similarity to hypothetical protein P0034C11.5 - Oryza sativa
An07g07780	Function: Inh1p of S. cerevisiae forms a one-to-one complex with ATPase to inhibit enzyme activity completely.; Remark: the systematic genename of INH1 of S. cerevisiae is YDL181w.; Title: similarity to mitochondrial H+-transporting ATP synthase inhibitor precursor Inh1 - Saccharomyces cerevisiae; See PMID 10838056; See PMID 2138617
An07g07790	Function: Nsp1 is located at the nuclear periphery in yeast and is essential for cell growth.; Function: the nucleoporin Nsp1 from S. cerevisiae is involved in the process of nuclear and/or cell division.; Localization: Nsp1p resides in three distinct subcomplexes of the nuclear pore complex which are located at the entry and exit of the central gated channel and at the terminal ring of the nuclear basket.; Remark: nucleoporins may be involved in both binding and translocation of the proteins during nucleocytoplasmic transport.; Title: similarity to nucleoporin Nsp1 -Saccharomyces cerevisiae; See PMID 9813081; See PMID 2112428; See PMID 3072197
An07g07800	Title: similarity to hypothetical protein SPAC8E11.05c - Schizosaccharomyces pombe
An07g07810	Title: weak similarity to protein inhibitor of activated STAT protein PIASX - Homo sapiens
An07g07820	Function: Pob1p of S. pombe exhibits subcellular localization close to actin patches, is essential for cell elongation and separation.; Similarity: shows also similarity to Boi2p of S. cerevisiae.; Title: similarity to cell elongation and separation protein ob1p - Schizosaccharomyces pombe; See PMID 10436025
An07g07830	Title: similarity to hypothetical protein YIL039w -Saccharomyces cerevisiae
An07g07840	Remark: L23 of S. cerevisiae is also called RPL17b,YBL0713, YBL087c, YER117w, or YL17a.; Similarity: most homologs are about 50 amino acids shorter at N-terminus.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L23 - Saccharomyces cerevisiae; cytoplasm
An07g07850	Function: histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones.; Function: histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events.; Function: the acetylation and deacetylation of histones is involved in the regulation of transcription and replication of DNA.; Title: strong similarity to histone deacetylase rpd3A - Aspergillus nidulans; See PMID 9780836; See PMID 11004483
An07g07860	Complex: the 26S proteasome is made up of two multisubunit complexes, the 20S catalytic core and the 19S regulatory complex.; Function: Pad1 has been isolated as a subunit of the 26 S proteasome in fission yeast.; Remark: the 26S proteasome is the multiprotein complex that degrades proteins that have been marked for destruction by the ubiquitin pathway.; Similarity: shows strong similarity to S. cerevisiae 19S proteasome regulatory particle Rpn11p.; Title: strong similarity to 26S proteasomal subunit ad1p - Schizosaccharomyces pombe; See PMID 9727008; See PMID 10582238
An07g07870	Similarity: C-terminus shows similarity to C-terminal part of restless-like transposase of N. haematococca.; Title: weak similarity to hypothetical restless-like transposase - Nectria haematococca
An07g07880	Remark: similarity to human ORFX ORF2689 polypeptide sequence SEQ ID NO:5378 patent WO200058473-A2.; Title: similarity to ORFX ORF2689 polypeptide sequence SEQ ID NO:5378 from patent WO200058473-A2 - Homo sapiens
An07g07910	Remark: a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing. The SRm160/300 complex associates with splicing complexes and promotes splicing through interactions with SR family proteins.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; See PMID 9531537
An07g07930	Remark: LEU3 gene, whose product is involved in the specific regulation of the leucine and possibly the isoleucine-valine pathways, is itself under general amino acid control.; Remark: LEU3 is necessary for expression of wild-type levels of LEU1- and LEU2-specific RNAs and,further, that the levels of LEU4-specific transcripts are also affected by LEU3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; See PMID 2823102; See PMID 3299266
An07g07940	Title: similarity to hypothetical protein B13A5.70 -Neurospora crassa
An07g07960	Remark: putative regulator element in A. terreus for lovastatin or monacolin J production.; Remark: weak similarity to A. terreus ORF5 protein patent WO200037629-A2.; Title: weak similarity to ORF5 protein from patent WO200037629-A2 - Aspergillus terreus
An07g07970	Catalytic activity: ATP + protein = ADP + O-phosphoprotein.; Remark: N-terminal truncated ORF due to end of contig.; Remark: RCK2 encodes a 65-kDa protein with similarity to second messenger-regulated kinase. Disruption of these gene demonstrates that it is non-essential. s; Similarity: belongs to the unassigned Ser/Thr or Tyr-specific protein kinases.; Title: strong similarity to Ca/calmodulin-dependent ser/thr protein kinase Rck2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 8112585
An07g07980	Remark: SVOP and SV2 are more distantly related to eukaryotic and bacterial phosphate, sugar, and organic acid transporters. SVOP is expressed at detectable levels only in brain and endocrine cells where it is primarily localized to synaptic vesicles and microvesicles.; Remark: strong similarity to EST an_3633 from Aspergillus niger.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to SV2 related protein SVOP - Rattus norvegicus; See PMID 9801366
An07g08010	Remark: nudF E. nidulans is required for nuclear migration during vegetative growth as well as development.; Title: strong similarity to nuclear migration factor nudF - Aspergillus nidulans; See PMID 7612965
An07g08030	Catalytic activity: release of a C-terminal amino acid with a broad specificity. Preferential release of a C-terminal arginine or lysine residue.; Function: removes any amino acid from the c-terminus of a long peptide. digests preferentially peptides containing a positively charged residue in p1' position, as well as arginine, lysine or phenylalanine in p1 position of ester substrate. optimal ph is 4; enzyme is unstable above pH 8. catalyze also peptide synthesis.; Gene-ID: pepF; Mapping: pepF from A. niger is mapped to chromosome IV; see PUBMED 9309173.; Remark: pepF is transcribed as a single 1. 8-kb mRNA, which is regulated by nitrogen and carbon repression,specific induction and the pH of the culture medium.; Remark: the enzyme had a pH optima of about 4 and was unstable above pH 7. It is specific for Arg, Lys, and Phe in P1.; Similarity: belongs to the peptidase family s10; also known as the serine carboxypeptidase family.; See PMID 7828908
An07g08040	Remark: the complete pepF is ORF 40CG.; Title: strong similarity to EST serine carboxypeptidase pepF - Aspergillus niger
An07g08050	Remark: the complete pepF is ORF 40CG.; Title: strong similarity to EST serine carboxypeptidase pepF - Aspergillus niger
An07g08060	Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical membrane protein YOL119c - Saccharomyces cerevisiae [truncated ORF]
An07g08080	Remark: A. niger EST an_1127 can be found in EMBLEST (AC:BE760196. 1).; Similarity: the ORF shows weak similarity to mitochondrial NADH dehydrogenases (EC 1. 6. 5. 3), but the ORF is 321 amino acids shorter.; Title: strong similarity to EST an_1127 -Aspergillus niger
An07g08090	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 58 amino acids.; Title: questionable ORF
An07g08100	Function: nik-1 of N. crassa is a two-component autophosphorylating histidine kinase that is involved in hyphal development of the fungi.; Phenotype: deletion of the nik-1+ gene in N. crassa results in an organism that displays aberrant hyphal structure, which is enhanced under conditions of high osmostress.; Remark: nik-1 of N. crassa is identical to a predicted os-1+ protein.; Similarity: the ORF shows similarity to several osmosensing histidine kinases from different species.; Title: strong similarity to histidine kinase nik-1 -Neurospora crassa; See PMID 9142740
An07g08110	Function: the sequence of the predicted ORF shows similarity to a 8-residue repeats containing M. musculus sequence, which is believed to be conserved in eukaryotic genomes.; Title: similarity to hypothetical protein T2 - Mus musculus; See PMID 1458435
An07g08130	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 100 amino acids.; Title: questionable ORF
An07g08140	Catalytic activity: the phenylalanyl-tRNA synthetase fre2 of S. cerevisiae converts ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Complex: the cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast is a tetramer of the alpha 2 beta 2 type, of which fre2 is one subunit.; Remark: fre2 of S. cerevisiae is also called YFL022C.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to cytosolic phenylalanine--tRNA ligase beta subunit Frs2 -Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 2644133
An07g08160	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0868 and an_0871 .; Title: weak similarity to RP2 - Mus musculus; See PMID 3755524
An07g08170	Catalytic activity: Inosine-5'-monophosphate dehydrogenases convert Inosine 5'-phosphate + NAD(+) + H(2)O to xanthosine 5'-phosphate + NADH.; Function: C. albicans IMH3 is the key enzyme in the de novo biosynthesis of GMP.; Title: strong similarity to IMP dehydrogenase IMH3 -Candida albicans; See PMID 9079920
An07g08190	Function: barley glucose dehydrogenase is involved in carbohydrate metabolism during embryogenesis.; Title: strong similarity to glucose dehydrogenase -Hordeum vulgare; See PMID 7764620
An07g08200	Title: weak similarity to secreted form of protein F - Human respiratory syncytial virus
An07g08210	Complex: human IQGAP1 binds to beta-catenin, actin,members of the Rho family, E-cadherin and calmodulin.; Function: binding of human IQGAP1 maintained Cdc42 in the active GTP-bound state.; Function: human IQGAP1 induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion, and is inhibited by Cdc42 and Rac1.; Function: human IQGAP1 is an effector for Cdc42 and Rac1 and has been shown to regulate cadherin function through its interaction with beta-catenin.; Localization: E-cadherin is required for accumulation of human IQGAP1 at cell-cell junctions.; Regulation: Calmodulin regulates the association of human IQGAP1 with Cdc42 and actin.; Title: strong similarity to cytoskeleton regulator IQGAP1 - Homo sapiens; cytoskeleton; See PMID 9867866; See PMID 10448058; See PMID 10508646; See PMID 10608854
An07g08220	Complex: human epsin 2 interacts with clathrin,Eps15 and the clathrin adaptor AP-2.; Function: high overexpression of human green fluorescent protein-epsin 2 mislocalizes components of the clathrin coat and inhibits clathrin-mediated endocytosis.; Localization: human epsin 2 is present in a clathrin-coated vesicle fraction, is concentrated in the peri-Golgi region and at the cell periphery of transfected cells.; Title: strong similarity to clathrin associated epsin 2A - Homo sapiens; intracellular transport vesicles; See PMID 10567358
An07g08230	Catalytic activity: Glutathione transferases convert RX + glutathione to HX + R-S-glutathione.; Function: Rhodococcus isoJ has activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1, 2-epoxy-2-methyl-3-butene.; Function: Rhodococcus isoJ is a glutathione S-transferase involved in isoprene (2-methyl-1,3-butadiene) utilization.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003
An07g08240	Complex: S. cerevisiae NBP2 interacts with Nap1p, a nucleosome assembly factor, as shown by two-hybrid.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal half of S. cerevisiae NBP2, which is 130 aa shorter.; Title: similarity to Nbp2 - Saccharomyces cerevisiae; See PMID 10767562
An07g08250	Title: similarity to hypothetical protein 53H1.090 -Neurospora crassa
An07g08280	Catalytic activity: 3-Hydroxy-3-methylglutaryl-CoA reductases convert (R)-mevalonate + CoA + 2 NADP(+) to (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: G. fujikuroi HMGR is involved in the control of cholesterol biosynthesis as it is the rate-limiting enzyme of the sterol biosynthesis.; Function: G. fujikuroi HMGR is the first specific enzyme of the isoprenoid pathway.; Localization: G. fujikuroi HMGR is an integral membrane protein of the endoplasmic reticulum.; Title: strong similarity to 3-Hydroxy-3-methylglutaryl-CoA reductase HMGR - Gibberella fujikuroi; endoplasmatic reticulum; See PMID 9000379
An07g08290	Complex: by two-hybrid S. cerevisiae Spa2p interacts with Pea2p and Bud6p (Aip3p), which has been shown previously to interact with actin.; Complex: by two-hybrid S. cerevisiae Spa2p interacts with signal transduction components Ste11p (MAPK kinase [MEK] kinase) and Ste7p (MEK) of the mating signaling pathway as well as with the MEKs Mkk1p and Mkk2p of the Slt2p (Mpk1p) MAPK pathway.; Complex: by two-hybrid S. cerevisiae Spa2p interacts with the Cdc42, Rho1 and proffilin interacting scaffolding proteins Bni1p and Bnr1p.; Function: S. cerevisiae Spa2p is important for polarized morphogenesis during budding, mating, and pseudohyphal growth.; Function: S. cerevisiae Spa2p likely influences morphogenesis by mediating input from MAPK signal transduction cascades to the actin cytosceleton.; Localization: S. cerevisiae Spa2p localizes to growth sites, likely forming an 12S complex with Pea2p and Bud6p which binds to the actin cytosceleton.; Similarity: a central region of ~400 aa from S. cerevisiae SPA2 shows no similarity to the predicted A. niger protein, which is 400 aa shorter.; Title: similarity to actin cytoskeleton organiser Spa2 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9632790; See PMID 9868371; See PMID 10938101; See PMID 11154270; See PMID 2647769
An07g08300	Function: peptidyl-prolyl cis-trans isomerases influence proline conformation and thereby protein structure, playing critical roles in many cellular functions like arrangement of protein complexes, stress response or signal transduction.; Gene-ID: cypA; Remark: a splice site was detected upstream of the START codon.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_1816, 3552, 2103, 0716, 3379 and 1375.; See PMID 11810223
An07g08310	Complex: S. pombe Ctr4 and Ctr5 associate in vivo,forming a heteromeric plasma membrane complex.; Function: S. pombe Ctr4 is a subunit of the high affinity copper transporter.; Localization: S. pombe Ctr4 and Ctr5 are interdependent for secretion to the plasma membrane.; Regulation: expression of S. pombe Ctr4 is regulated by copper levels and the copper-sensing transcription factor Cuf1.; Title: similarity to high affinity copper transporter ctr4p - Schizosaccharomyces pombe; plasma membrane; See PMID 11274192
An07g08320	Catalytic activity: Polyribonucleotide nucleotidyltransferases convert {RNA}(N+1) + phosphat to {RNA}(N) + a nucleoside diphosphate.; Complex: S. cerevisiae Ski6 is a component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins; rrp4, rrp40, rrp41/ski6, rrp42, rrp43,rrp44/dis3, rrp45, rrp46, mtr3, csl4 and rrp6 (only in the nuclear complex).; Function: S. cerevisiae SKI6 is a exosome subunit and thereby involved in the processing of all RNA species.; Function: S. cerevisiae ski6-2 mutants accumulate a 38S particle, apparently an incomplete or degraded 60S ribosomal subunit, containing the 3'-terminus of 25S rRNA but no 5. 8S rRNA.; Function: primary effect of S. cerevisiae Ski6p was on efficiency of translation, as ski6 mutations bypass the requirement of the poly(A) tail for translation.; Localization: the exosome localises to nucleus and cytosol.; Remark: alternative names for S. cerevisiae SKI6 are ECM20, RRP41 and YGR195w.; Title: strong similarity to 3-5 exoribonuclease Ski6 - Saccharomyces cerevisiae; See PMID 9566888; See PMID 10571176; See PMID 10930416
An07g08330	Complex: human CSB is a DNA-binding protein, and it also binds to XPA, TFIIH, and the p34 subunit of TFIIE.; Function: human CSB has an ATPase activity that is stimulated strongly by DNA; however, it neither acts as a helicase nor does it dissociate stalled RNA polymerase II.; Function: human CSB is involved in UV induced DNA-repair and likely plays a role in recruiting repair proteins to ternary complexes formed at damage sites.; Title: strong similarity to transcription-repair coupling factor CSB/ERCC6 - Homo sapiens; nucleus; See PMID 8999876
An07g08340	Function: different OSBPs have different functions,like mediation of sterol and phospholipid synthesis (HES1) or regulation of the Sec14p pathway for Golgi-derived vesicle transport (KES1).; Function: mutations in S. cerevisiae hes1 result in pleiotropic sterol-related phenotypes.; Function: oxysterol binding proteins (OSBPs) are a family of eukaryotic intracellular lipid receptors.; Similarity: S. cerevisiae HES1 and the predicted A. niger protein show strong similarity to human oxysterol binding protein (OSBP) and several putative fungal OSBPs.; Title: similarity to ergosterol synthesis protein Hes1 - Saccharomyces cerevisiae; See PMID 11279184; See PMID 8017104
An07g08350	Title: strong similarity to hypothetical protein YPL067c - Saccharomyces cerevisiae
An07g08360	Catalytic activity: nicotinamidases convert nicotinamide + H(2)O to nicotinate + NH(3).; Function: E. coli pncA is involved in Pyridine nucleotide cycle.; Title: similarity to pyrazinamidase/nicotinamidase pncA - Escherichia coli; See PMID 8726014
An07g08370	Complex: S. cerevisiae Ssu72 protein interacts directly with purified RNA-Pol II in a coimmunoprecipitation assay.; Function: in S. cerevisiae a mutation in RNA-Pol II (rpb2-100) was isolated as a suppressor of the ssu72-2 Ts(-) defect, but enhanced the transcriptional defects associated with ssu72-2.; Function: in S. cerevisiae a recessive ssu72-1 allele was identified as a synthetic enhancer of a TFIIB (sua7-1) defect, resulting in a heat-sensitive (Ts(-)) phenotype and a dramatic downstream shift in transcription start site selection.; Function: in S. cerevisiae the ssu72-2 and rpb2-100 mutations adversely affected noninduced gene expression,with no apparent effects on activated transcription in vivo.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for S. cerevisiae SSU72 isYNL222w.; Title: strong similarity to RNA-Pol II interacting Ssu72 - Saccharomyces cerevisiae; See PMID 11046131
An07g08380	Function: S. cerevisiae HOS2 is a histone deacetylase.; Function: in S. cerevisiae phenotypes caused by mutations in the histone acetylases gcn5 and elp3 are suppressed by concomitant mutation of the HDA1 and HOS2 histone deacetylases.; Remark: the systematic name for S. cerevisiae HOS2 is YGL194c.; Title: strong similarity to histone deacetylase Hos2 - Saccharomyces cerevisiae; See PMID 10856249; See PMID 8962081
An07g08390	Function: carboxyphosphonoenolpyruvate mutase catalyses the formation of one of the two C-P bonds in bialaphos (L-phosphinothricinyl-L-alanyl-L-alanine), a potent herbicide isolated from Streptomyces hygroscopicus.; Title: strong similarity to carboxyphosphonoenolpyruvate mutase - Streptomyces hygroscopicus; See PMID 1330557
An07g08400	Title: strong similarity to allergen rAsp f 4 -Aspergillus fumigatus; See PMID 10482834
An07g08410	Title: weak similarity to hypothetical protein encoded by An11g06480 - Aspergillus niger
An07g08420	Remark: ORF 3'truncated due to end of contig.
An07g08430	Complex: a yeast two-hybrid screen with metaxin 1 as bait has identified a novel protein, termed metaxin 2, as a metaxin 1-binding protein.; Function: in cell culture overexpression of human metaxin resulted in impaired mitochondrial import of natural and chimeric preproteins and in their accumulation.; Function: metaxin is an outer membrane protein of mammalian mitochondria which is suggested to be involved in protein import into the organelle.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to mitochondrial preprotein import complex subunit metaxin MTX - Homo sapiens [truncated ORF]; localisation:mitochondrion; See PMID 8660965; See PMID 10381257; See PMID 11027586
An07g08470	Title: similarity to hypothetical protein G17B7.120 - Neurospora crassa
An07g08480	Remark: N-terminally truncated due to contig border.
An07g08490	Function: the 3'-5' helicase PcrA unwinds helical DNA substrates coupled to the hydrolysis of ATP.; Remark: the crystal structure of a monomeric form of the DNA helicase PcrA from Bacillus stearothermophilus,alone and in a complex with ADP, at 2. 5 and 2. 9 A resolution, has been solved.; Similarity: PcrA belongs to the UvrD subfamily of helicases.; Title: similarity to ATP-dependent helicase pcrA -Bacillus stearothermophilus; nucleus; See PMID 8934527; See PMID 9592155
An07g08500	Title: weak similarity to Vpr binding protein HHR23A from patent WO9835032-A2 - Homo sapiens
An07g08520	Complex: CCN1 interacts with the CDC2 protein kinase to form MPF.; Function: CCN1 is essential for the control of the cell cycle at the G1/S (Start) transition.; Similarity: CCN1 belongs to the cyclin family.; Title: similarity to G1/S-specific cyclin CCN1 -Candida albicans; See PMID 1409649; See PMID 7830719
An07g08580	Title: weak similarity to RAD1 binding protein from patent WO9949042-A1 - Mus sp.
An07g08590	Title: strong similarity to protein SEQ ID NO:7145 from patent WO200253728-A2 - Candida albicans
An07g08600	Protein sequence is in conflict with the conceptual translation; Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.; Function: PPZ1 plays a role in regulating osmotic stability.; Title: strong similarity to phosphoprotein phosphatase Ppz2 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 8395014; See PMID 8396031
An07g08610	Title: weak similarity to ovarian tumor EST fragment encoded protein 57 from patent DE19817557-A1 - Homo sapiens
An07g08620	Title: similarity to hypothetical protein AAN74824.1 - Gibberella moniliformis
An07g08630	Title: strong similarity to hypothetical protein At2g25280 - Arabidopsis thaliana
An07g08640	Function: mutA of P. purporogenum hydrolysis 1,3-alpha-D-glucosidic links.; Remark: P purporogenum mutA is also named alpha1,3-glucanase.; Title: strong similarity to mutanase mutA -Penicillium purporogenum; See PMID 10636904
An07g08670	Remark: similarities correspond to multiple serine repeats.; Title: weak similarity to hypothetical protein RtoA - Dictyostelium discoideum
An07g08680	Title: weak similarity to hypothetical protein encoded by CG15782 - Drosophila melanogaster
An07g08690	Catalytic activity: the S. cerevisiae homolog Png1p hydrolyses an N4-(acetyl-beta-D-glucosaminyl)asparagine residue to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.; Title: similarity to cytoplasmic peptide:N-glycanase Png1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10831608
An07g08710	Catalytic activity: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate; Gene-ID: tpsB; See PMID 8666204; See PMID 9006911
An07g08720	Catalytic activity: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate; Title: strong similarity to 123K chain alpha,alpha-trehalose-phosphate synthase (UDP-forming) Tsl1 -Saccharomyces cerevisiae; See PMID 8404905; See PMID 8850521; See PMID 9837904
An07g08730	Complex: CAF-1 contains three subunits p150, p60,and p48.; Complex: only a fraction of total human p48 is associated with p150 and p60, and the majority is present in other high molecular weight complexes.; Function: CAF-1 (Chromatin Assembly Factor-I) efficiently mediates nucleosome assembly during complementary DNA strand synthesis in G1, S, and G2 phase.; Localization: during S phase, human p150 and p60 are concentrated at sites of intranuclear DNA replication.; Localization: in interphase, human p150 and p60 are bound to the nucleus, but they predominantly dissociate from chromatin during mitosis.; Regulation: in mitosis, the human p60 subunit of inactive CAF-1 is hyperphosphorylated, whereas active CAF-1 in interphase contains hypophosphorylated and/or phosphorylated forms of p60.; Title: strong similarity to chromatin assembly factor-I (CAF-I) p60 subunit Cac2 - Saccharomyces cerevisiae; nucleus; See PMID 9614144; See PMID 9927445
An07g08740	Remark: in T. brucei strain 427 ISG75 genes are present in tandem arrays at two loci, A and B, containing 5 and 2 copies, respectively.; Title: weak similarity to 75 kDa invariant surface glycoprotein ISG75 - Trypanosoma brucei; See PMID 1587856
An07g08750	Similarity: the predicted A. niger protein shows also similarity to different proline, glutamic acid and glutamine rich structural proteins, like Neurofilament triplet H1 and extensins.; Title: weak similarity to protein OlpB from patent FR2748479-A1 - Clostridium thermocellum
An07g08760	Catalytic activity: NADPH dehydrogenases catalyse the reaction, NADPH + acceptor = NADP+ + reduced acceptor.; Complex: S. cerevisiae OYE3 forms homodimers and heterodimers with other OYE Isoforms.; Function: S. cerevisiae OYE3 binds a variety of compounds with a phenolic structure.; Function: S. cerevisiae OYE3 has been shown to catalyze efficiently the NADPH-linked reduction of nitro-olefins.; Function: S. cerevisiae OYE3 might be involved in sterol metabolism.; Title: strong similarity to hypothetical NADPH dehydrogenase Oye3 - Saccharomyces cerevisiae; See PMID 10995477
An07g08770	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614
An07g08780	Remark: ORF classified questionable due to lack of similarities and length < 80 aa.; Title: questionable ORF
An07g08790	Remark: predicted A. niger protein is 300 aa shorter than wee1 from S. pombe.; Title: weak similarity to mitosis inhibitor protein kinase wee1p - Schizosaccharomyces pombe
An07g08800	Function: it has been suggested, that Hwp1 from C. albicans is a glucan-linked protein with serine/threonine-rich regions that are predicted to function in extending a ligand-binding domain into the extracellular space.; Title: weak similarity to hyphal wall protein 1 HWP1 - Candida albicans; See PMID 9639315
An07g08810	Complex: Gpr1 from S. cerevisiae binds to the G-protein Gpa2.; Function: in S. cerevisiae gpr1 is a nutrient sensor that regulates pseudohyphal differentiation.; Induction: in S. cerevisiae expression of the GPR1 gene is known to be induced by nitrogen starvation.; Induction: in S. cerevisiae the gpr1 receptor is activated by glucose and other structurally related sugars.; Pathway: in S. cerevisiae epistasis analysis supports a model in which the Gpr1 receptor regulates pseudohyphal growth via the Gpa2p-cAMP-PKA pathway and independently of both the MAP kinase cascade and the PKA related kinase Sch9.; Title: strong similarity to G protein-coupled receptor Gpr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10655215
An07g08820	Function: PAK family kinases regulate cytoskeletal changes mediated by Cdc42 and Rac.; Function: experiments in D. discoideum suggest that the assembly of myosin II into the cytoskeleton requires PAKa function.; Function: in D. discoideum paka null cells or wild-type cells expressing a kinase dead (putative dominant negative) PAKa produce many random, lateral pseudopodia and have a much higher frequency of making wrong turns than wild-type cells.; Localization: PAKa colocalizes with myosin II to the cleavage furrow of dividing cells and the posterior of polarized, chemotaxing cells via its NH(2)-terminal domain.; Similarity: the predicted A. niger protein shows similarity to central region of DPAKA, which is 500 aa longer.; Similarity: the predicted A. niger protein shows similarity to serine and proline rich proteins.; Title: weak similarity to hypothetical protein LcoB - Lactococcus lactis
An07g08830	Complex: YAP180 from S. cerevisiae binds Pan1p and clathrin.; Function: AP deletion strains in S. cerevisiae suggest that clathrin function and recruitment onto membranes are not dependent upon heterotetrameric adaptors or AP180 homologs.; Localization: in S. cerevisiae yAP180 proteins and Pan1p, like actin, localize to peripheral patches along the plasma membrane.; Remark: YGR241C is the systematic name for YAP180.; Similarity: YAP180 from S. cerevisiae is a member of the AP180 protein family.; Title: strong similarity to adaptor protein Yap180 -Saccharomyces cerevisiae; cytoskeleton; See PMID 10406795
An07g08840	Similarity: only C-terminal region of predicted A. niger protein shows similarity to human WDR9, which is 1700 aa longer.; Title: weak similarity to hypothetical WDR9 - Homo sapiens
An07g08850	Complex: RPS11B from S. cerevisiae is a component of the cytosolic small ribosomal subunit 40S.; Function: RPS11B from S. cerevisiae is a structural protein of the ribosome and controls translational accuracy as well as ribosomal small subunit assembly and maintenance.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rps11b - Saccharomyces cerevisiae; cytoplasm
An07g08860	Remark: ORF C-terminally truncated due to end of contig.; Similarity: predicted A. niger protein shows unspecific similarity to serine and glutamic acid rich proteins.; Title: weak similarity to dentin phosphophoryn -Homo sapiens [truncated ORF]
An07g08870	Remark: ntf1 plays an important role in regulating nmt1 expression, which is subject to transcriptional repression mediated by thiamine in Schizosaccharomyces pombe.; Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491
An07g08880	Remark: cys-3, the positive-acting master sulfur regulatory gene of Neurospora crassa, turns on the expression of an entire set of unlinked structural genes which encode sulfur-catabolic enzymes.; Title: strong similarity to positive sulphur regulator CYS3 - Neurospora crassa; nucleus; See PMID 2142156; See PMID 2524646
An07g08890	Title: strong similarity to hypothetical protein YGR086c - Saccharomyces cerevisiae
An07g08900	Title: similarity to hypothetical WD-repeat protein WDR6 - Homo sapiens
An07g08910	Catalytic activity: NAD(P)H + Nitrate = NAD(P)+ + Nitrite + H2O.; Title: strong similarity to nitrate reductase NR1 -Zea mays [putative frameshift]; putative frameshift; See PMID 9576798; See PMID 10773339; See PMID 11244107
An07g08920	Catalytic activity: NAD(P)H + Nitrate = NAD(P)+ + Nitrite + H2O.; Title: strong similarity to nitrate reductase NR -Betula pendula; See PMID 1675424
An07g08930	Catalytic activity: nitrous oxide + H2O + acceptor = 2 nitric oxide + reduced acceptor.; Title: strong similarity to nitric-oxide cytochrome P-450 reductase Cyp55 - Fusarium oxysporum; See PMID 7798191
An07g08940	Similarity: acetyl-esterase I of patent WO9502689-A of A. aculeatus shows acetyl esterase activity on acetylated xylan and mannan; it is used in the preparation of feed or food, and in the paper or pulp industry.; Similarity: shows similarity to several lipases,esterases.; Title: similarity to acetyl-esterase I from patent WO9502689-A - Aspergillus aculeatus
An07g08950	Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Gene-ID: eglB; extracellular/secretion proteins; See PMID 9758775
An07g08960	Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe
An07g08970	Similarity: blast hits are caused by repetetive sequence motives.
An07g08980	Catalytic activity: Fab1 in S. cerevisiae transfers a phosphate group from ATP to the 5-hydroxyl of phosphatidylinositol-3-phosphate.; Function: Fab1 in S. cerevisiae is regulated by Vac7.; Induction: Fab1 in S. cerevisiae is activated under hyperosmotic stress conditions.; Pathway: Fab1 in S. cerevisiae constitutes the key kinase in a signal transduction pathway involved in vacuolar membrane homeostasis.; Pathway: Fab1 in S. cerevisiae is involved in cargo-selective trafficking from multivesicular bodies to the vacuolar lumen.; Pathway: Fab1 in S. cerevisiae is not required for the biogenesis of the vacuole.; Pathway: the product of Fab1 activity in S. cerevisiae, phosphatidylinositol-3,5-bisphosphate, is a key regulator for vacuolar membrane turnover/recycling.; Remark: phosphatidylinositol 3-phosphate 5-kinases containing the RING-FYVE-finger domain are referred to as Type III PIP-kinases.; Similarity: the strong homology regions include the N-terminal cysteine-rich RING-FYVE-finger zinc-binding domain and the C-terminal PIP-5-kinase domain.; Title: strong similarity to phosphatidylinositol 3-phosphate 5-kinase Fab1 - Saccharomyces cerevisiae; vacuole; See PMID 9763421; See PMID 9811604; See PMID 9865702; See PMID 7663021
An07g08990	Catalytic activity: pyruvate kinases transfer a phosphate group from phosphoenolpyruvate to ADP producing pyruvate and ATP.; Gene-ID: pkiA; Pathway: pyruvate kinases catalyze the last, and irreversible, step of glucose degradation to pyruvate.; cytoplasm; See PMID 1611667
An07g09005	Title: strong similarity to hypothetical protein SPAC26A3.14c - Schizosaccharomyces pombe
An07g09010	Similarity: homology to T17H3. 1 from A. thaliana covers only it's C-terminal part.; Similarity: the N-terminus also shows homology to human F-box containing proteins.; Title: weak similarity to hypothetical protein T17H3.1 - Arabidopsis thaliana
An07g09020	Title: weak similarity to polypeptide SEQ ID NO:3357 from patent WO2003052076-A2 - Cryptococcus neoformans
An07g09040	Similarity: shows deliberate matches to a variety of hihgly repetitive proteins.; Title: weak similarity to INSP010 from patent WO2003051919-A1 - Homo sapiens
An07g09050	Similarity: the C-terminus is about 120 aa shorter than in SC5F2A. 29 of S. coelicolor.; Title: similarity to hypothetical transcription regulator SC5F2A.29 - Streptomyces coelicolor
An07g09060	Title: strong similarity to hypothetical protein CAE76244.1 - Neurospora crassa
An07g09070	Title: strong similarity to hypothetical protein YMR158w - Saccharomyces cerevisiae
An07g09090	Title: weak similarity to hypothetical protein encoded by An18g02770 - Aspergillus niger
An07g09110	Function: the monooxygenase VioC is involved in late steps of violacein biosynthesis.; Remark: the violacein biosynthetic gene cluster spans eight kilobases and is comprised of the four genes,vioABCD, that are necessary for violacein production.; Remark: violacein is a purple-colored,broad-spectrum antibacterial pigment that has a dimeric structure composed of 5-hydroxyindole, oxindole and 2-pyyrolidone subunits formed by the condensation of two modified tryptophan molecules.; Title: similarity to monooxygenase VioC -Chromobacterium violaceum; See PMID 11075927
An07g09120	Function: MAP1 cleaves methionine from nascent polypeptide chains.; Pathway: methionine aminopeptidase is one of the central enzymes in protein synthesis.; Remark: gene models derived from different cDNA sequences suggest alternativ splicing of the first intron. The two proposed alternative N-termini of the protein would be 'MPQGRHGQLLLLAGLFQTELGRLPYVTHQAH SEHKTIHK. . . ' and 'MAEVATRKCMGVDCDKNAGTLQCPTCLKAGTDSFFCSQDCFKRSW SEHKTIHK. . . '.; Similarity: MAP1 consists of two functional domains: a unique NH2-terminal domain containing two motifs resembling zinc fingers, which may allow the protein to interact with ribosomes, and a catalytic COOH-terminal domain resembling prokaryotic methionine aminopeptidases.; Title: strong similarity to precursor of methionyl aminopeptidase Map1 - Saccharomyces cerevisiae; See PMID 1569059
An07g09130	Title: strong similarity to SRT protein sequence SEQ ID NO:248 from patent WO200100804-A2 - Corynebacterium glutamicum
An07g09140	Remark: C-terminally truncated due to contig border.; Title: weak similarity to protein herc2 - Mus musculus [truncated ORF]
An07g09150	Function: PRP17 encodes a protein that participates in the second step of the splicing reaction (is spliceosome-associated) and is required for initiation and completion of S-phase and for initiation and completion of DNA replication.; Remark: PRP17 of S. cerevisiae is identical to the cell division cycle CDC40 gene.; Remark: a yeast-human PRP17 chimera is able to complement the cell cycle and splicing defects of a yeast prp17 mutant.; Similarity: the ORF overlaps with the A. niger EST an_3051 in EMBLEST:BE758807 at it's C-terminus.; Title: strong similarity to splicing factor PRP17 -Homo sapiens; See PMID 9769104; See PMID 9830021
An07g09160	Function: cni of D. melanogaster is necessary for both anterior-posterior and dorsal-ventral pattern formation.; Function: it is proposed that the cornichon homolog YGL054c (Erv14) of S. cerevisiae is required for formation of COPII-coated ER-derived transport vesicles.; Phenotype: mutations in the cni gene of D. melanogaster prevent the formation of a correctly polarized microtubule cytoskeleton, which is required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.; Remark: cni of D. melanogaster belongs to the cornichon family.; Title: strong similarity to pattern formation protein cni - Drosophila melanogaster; See PMID 9732282; See PMID 7540118
An07g09170	Function: BCRP1 of M. musculus is a multidrug-resistance protein.; Function: BCRP1 of M. musculus renders tumor cells resistant to the anticancer drugs topotecan, mitoxantrone,doxorubicin, and daunorubicin.; Remark: BCRP1 of M. musculus is a member of the adenosine triphosphate-binding cassette (ABC) family of drug transporters.; Remark: BCRP1 of M. musculus is also designated ABCP and MXR.; Similarity: about 400 N-terminal amino acids of the ORF are not aligned with BCRP1 of M. musculus.; Similarity: the ORF overlaps with the A. niger ESTs an_2679 in EMBLEST:BE759768 and an_2660 in EMBLEST:BE759753.; Title: strong similarity to breast cancer resistance protein 1 BCRP1 - Mus musculus; See PMID 10485464; See PMID 11036110
An07g09180	Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Complex: the AspAT protein of Thermus aquaticus forms a homodimer.; Remark: AspAT of Thermus aquaticus belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Remark: the AspAT protein of Thermus aquaticus is rich in proline residues, and is very thermostabile.; Remark: the AspAT protein of Thermus aquaticus is strictly specific for acidic amino acid substrates, such as aspartate, glutamate, and the respective keto acids.; Similarity: AspAT of Thermus aquaticus shows also similarity to some transaminases of other specificities.; Title: strong similarity to aspartate transaminase AspAT - Thermus aquaticus; See PMID 10029535; See PMID 8907187
An07g09190	Catalytic activity: ATP + a very long-chain carboxylic acid + CoA = AMP + Pyrophosphate + an Acyl-CoA; Function: the FAT1 protein of S. cerevisiae has,additionally, a very-long-chain acyl-CoA synthetase (VLCS) activity, thus enabling beta-oxidation of very long chain fatty acids.; Function: the FAT1 protein of S. cerevisiae is required for maximal levels of fatty-acid import.; Remark: FAT1 of S. cerevisiae belongs to the ATP-dependent AMP-binding enzyme family.; Similarity: 82 N-terminal amino acids of the ORF are not aligned with FAT1 of S. cerevisiae.; Title: strong similarity to very long-chain fatty acyl-CoA synthase Fat1 - Saccharomyces cerevisiae; See PMID 9660783; See PMID 9988704; See PMID 10880966; See PMID 9079682
An07g09200	Function: 2-5A-dependent RNAase of M. musculus is activated by 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A) and controls RNA stability.; Remark: 2-5A-dependent RNAase of M. musculus is a key enzyme of IFN-induced viral defence.; Similarity: the ORF shows only local similarity (125 aligned amino acids) to 2-5A-dependent RNAase of M. musculus; furthermore the characterized domains of M. musculus 2-5A-dependent RNAase are not included in the alignment.; Title: weak similarity to 2-5A-dependent RNAase -Mus musculus; See PMID 7680958
An07g09210	Remark: the ORF has an unusual intron/exon structure for A. niger.
An07g09220	Similarity: the ORF shows local similarity to PA0878 of P. aeruginosa: 237 amino acids are aligned.; Title: similarity to hypothetical protein PA0878 -Pseudomonas aeruginosa
An07g09230	Remark: the ORF contains a glutamine-rich stretch.; Remark: the ORF contains many positive charged amino acids.; Remark: the ORF encompasses a zinc-finger and could thus be involved in DNA-binding.; Similarity: the ORF shows local similarity to SPAC1F7. 11c of S. pombe (aligned amino acids: 4-505).; Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe
An07g09240	Remark: the ORF shows local strong similarity to SPCC16A11. 07 of S. pombe: 88 N-terminal amino acids of the ORF are excluded from the alignment.; Title: strong similarity to hypothetical protein SPCC16A11.07 - Schizosaccharomyces pombe
An07g09250	Catalytic activity: 2 peroxide radical + 2 H(+) <=> O(2) + H(2)O(2).; Function: the sodB protein of H. pylori detoxifies radicals.; Phenotype: sodB mutants of H. pylori are devoid of superoxid dismutase (SOD) activity.; Phenotype: sodB mutants of H. pylori are even more sensitive to O2 than wildtype H. pylori; the mutants are also more sensitive to H2O2.; Phenotype: sodB mutants of H. pylori show an increased mutation rate.; Remark: the sodB protein of H. pylori is a virulence factor which affects the ability to colonize the host and is important for the growth and survival of H. pylori under conditions of oxidative stress.; Similarity: the ORF is longer than the sodB protein of H. pylori (308 compared to 213 amino acids) but due to gaps in the alignment it encompasses the whole ORF.; Title: similarity to superoxide dismutase sodB -Helicobacter pylori; See PMID 11349073
An07g09270	Similarity: the ORF shows local strong similarity to the hypothetical protein SPAC1F12. 09 of S. pombe: nearly 300 N-terminal amino acids are not included in the alignment.; Title: strong similarity to hypothetical protein SPAC1F12.09 - Schizosaccharomyces pombe
An07g09280	Title: strong similarity to hypothetical transmembrane protein SPAC30D11.11 - Schizosaccharomyces pombe
An07g09290	Remark: the ORF has an unusual exon/intron structure for A. niger.
An07g09300	Remark: the ORF has an unusual exon/intron structure for A. niger.
An07g09310	Remark: the ORF is short in length.
An07g09320	Catalytic activity: 2-hydroxymuconate semialdehyde + H(2)O <=> formate + 2-oxopent-4-enoate; Function: the phnD enzyme of Pseudomonas sp. is required for conversion of 2-hydroxymuconic semialdehyde,which is produced from catechol by the PhnE catechol 2,3-dioxygenase, to 2-hydroxypent-2,4-dienoate (EC 3. 7. 1. 9).; Similarity: the ORF shows local similarity to 2-hydroxymuconate-semialdehyde hydrolases of different species.; Similarity: the ORF shows local similarity to phnD of Pseudomonas sp. : the alignment comprises only amino acids 99-211 of the ORF.; Title: similarity to 2-hydroxymuconate-semialdehyde hydrolase phnD - Pseudomonas sp.; See PMID 9125165
An07g09325	Remark: the matching EST sequence covers only upstream sequences of the cbhA gene from A. niger.; Title: strong similarity to EST upstream of cbhA -Aspergillus niger
An07g09330	Catalytic activity: hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.; Gene-ID: cbhA; Induction: transcription of cbhA of A. niger is induced by D-xylose but not by sophorose and, in addition,requires the xylanolytic transcriptional activator XlnR.; Mapping: cbhA from A. niger is mapped to chromosome IV; see list from DSM, EMBL AF156268.; Pathway: cbhA of A. niger is involved in starch and sucrose metabolism.; Remark: the ORF is nearly identical to patent cbhB WO9906574-A1 in PATENTPROT:AAY00864, but differs in amino acids A86T, V170A and E359D.; Remark: the ORF overlaps with the sequence in EMBL:E32834, with sequence 5 from patent EP0897667 in EMBL:AX000304, with sequence 5 from patent WO9906574 in EMBL:AX000154, with cbhA of A. niger in EMBL:AF156268,with cbhA of A. niger in PATENTDNA:AAX21510, and with cbhA of A. niger in PATENTDNA:AAX22094.; See PMID 10508057
An07g09340	Remark: the ORF overlaps with the 5' end of the cellobiohydrolase (cbhA) sequence derived from A. niger in EMBL:AF156268. The cbhA gene lies in the adjacent contig.; Similarity: the ORF shows local weak similarity to striatin of R. norvegicus and H. sapiens over a stretch of 80 amino acids; this stretch encompasses WD repeats in the ORF and in the striatin sequence, thus the weak similarity between ORF and striatin is presumably unspecific; striatin is a calmodulin-binding protein, belonging to the WD-repeat family.; Title: similarity to hypothetical protein YPR169w -Saccharomyces cerevisiae
An07g09350	Similarity: the ORF shows also (weak) local similarity to WW-domain containing oxidoreductases of H. sapiens and M. musculus.; Title: strong similarity to hypothetical protein Rv0303 - Mycobacterium tuberculosis
An07g09360	Catalytic activity: 3-oxoadipate + NAD(P)(+) <=> 2-maleylacetate + NAD(P)H.; Function: MacA of R. opacus plays a major role in the degradation of chloroaromatic compounds.; Pathway: MacA of R. opacus is involved in 3-chlorocatechol degradation: this pathway is important for biodegradation of toxic aromatic compounds in the environment.; Remark: MacA of R. opacus converts 2-chloromaleylacetate, an intermediate in the degradation of dichloroaromatic compounds, to maleylacetate.; Remark: maleylacetate reductases allow bacteria to grow on chlorine containing substrates.; Remark: maleylacetate reductases play a major role in the degradation of chloroaromatic compounds by channelling maleylacetate and some chlorinated derivatives into the 3-oxoadipate pathway.; Similarity: MacA of R. opacus belongs to the iron-containing alcohol dehydrogenase family.; Title: strong similarity to maleylacetate reductase MacA - Rhodococcus opacus; See PMID 9657989
An07g09370	Phenotype: disruption of the DPH2 gene of S. cerevisieae leads to a viable phenotype.; Remark: DPH2 of S. cerevisiae confers resistance to diphteriae toxin.; Remark: the DPH2 gene of S. cerevisiae is also called YKL191W.; Remark: the DPH2 gene of S. cerevisiae was isolated by complementation of a diphthamide mutant.; Title: strong similarity to diphthamide synthesis protein Dph2 - Saccharomyces cerevisiae; See PMID 8406038
An07g09390	Complex: NudF of A. nidulans and LIS1 of mammals fisically interact with NudC, raising the possibility that a common molecular mechanism underlies both the defect of neural development observed in humans and the interphase nuclear movement defect observed in the fungus.; Function: a temperature-sensitive mutation in the nudC gene of A. nidulans specifically prevents the microtubule-based movement of nuclei in this organism at the restrictive temperature.; Phenotype: nudC of A. nidulans has gained a lot of interest in the scientific community due to the involvement of its mammalian homologue in the neurologic syndrome lissencephaly, characterized by abnormal development of the brain cortex.; Remark: lissencephaly in humans is caused by mutations in the LIS1 gene and, at the cellular level, is due to defects in neuronal fate specification in the ventricular zone and of following correct migration; LIS1 is the homologue of the A. nidulans NudF gene.; Title: strong similarity to nuclear movement protein nudC - Aspergillus nidulans; See PMID 9601647; See PMID 9861667; See PMID 2199460; See PMID 7612965
An07g09400	Remark: UPC2 of S. cerevisiae is also called YDR213W or MOX4.; Similarity: UPC2 of S. cerevisiae is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; the predicted protein does not contain such a domain.; Title: weak similarity to transcription activator Upc2 - Saccharomyces cerevisiae; See PMID 9696767
An07g09410	Function: pro1 of S. macrospora encodes a C6 zinc finger transcription factor required for fruiting body development.; Remark: The ORF is N-terminally truncated due to the contig border.; Similarity: more than 200 N-terminal (and in respect to the ORF 100 C-terminal) amino acids are excluded from the alignment between the ORF and pro1 of S. macrospora; This is partly caused by the N-terminal truncation of the ORF due to the contig border. The zinc finger is not found in the ORF sequence.; Title: strong similarity to fruiting body development transcription factor pro1 - Sordaria macrospora [truncated ORF]; See PMID 10224253
An07g09420	Remark: the ORF's exon/intron structure is unusual for A. niger and the ORF is short in length (87 amino acids).; Title: questionable ORF
An07g09430	Function: prtS of S. thermophilus is a serine proteinase highly activated by Ca(2+) ions.; Remark: prtS of S. thermophilus is a member of the subtilase family.; Similarity: the ORF shows local weak similarity to prtS of S. thermophilus: the ORF has a length of 306 amino acids and prtS has a length of 1585 amino acids, however,less than 100 amino acids are included in the alignment; furthermore the aligned sequence is proline-rich.; Title: weak similarity to cell envelope proteinase prtS - Streptococcus thermophilus; See PMID 11055922
An07g09440	Remark: the ORF overlaps with 5' and 3' sequence of the Aspergillus awamori Vader transposon Tan1 in EMBL:AA37228.; Remark: the ORF overlaps with sequences from patent WO9808960-A1 and WO9629414-A1 encoding the A. niger Vader transposable element Tan1.; Remark: the ORF overlaps with the UTR (untranslated region) of the neighbouring transposon Tan1.; Remark: the ORF's exon/intron structure is unusual for A. niger.
An07g09460	Gene-ID: Tan1; Remark: organization of Tan1: IR-ORF-IR-IR-Vader-IR.; Remark: the ORF is identical or nearly identical to WO9808960-A1 in PATENTPROT:AAW58866, WO9629414-A1 in PATENTPROT:AAW04877, and WO9808960-A1 in PATENTPROT:AAW58865.; Remark: the Tan1 element of A. niger encodes a putative transposase.; Similarity: the ORF overlaps with nucleic acid entries PATENTDNA:AAV11500, PATENTDNA:AAV11494,PATENTDNA:AAT38935, and PATENTDNA:AAF11280 in the patent database.; See PMID 9003286
An07g09470	Similarity: the ORF and the hypothetical protein of A. thaliana have roughly the same length; however, less than half of the amino acid sequence of the ORF is included in the alignment.; Title: strong similarity to hypothetical retroelement pol polyprotein - Arabidopsis thaliana
An07g09480	Remark: chapsyn-110 of R. norvegicus is a member of the PSD-95 family of proteins.; Remark: chapsyn-110 of R. norvegicus shows heteromultimerization and NMDA receptor-clustering activity.; Similarity: the ORF shows also local similarity to STE5 of S. cerevisiae.; Similarity: the ORF shows local similarity to chapsyn-110: about 200 amino acids of the 514 amino acid ORF and of the 830 amino acid chapsyn-110 are included in the alignment.; Title: weak similarity to channel associated protein of synapse-110 chapsyn-110 - Rattus norvegicus; See PMID 8755482
An07g09490	Remark: the ORF's exon/intron structure is unusual for A. niger.
An07g09510	Remark: unusual intron/exon structure for A. niger and short length (82 amino acids).; Title: questionable ORF
An07g09520	Remark: the ORF's exon/intron structure is unusual for A. niger.
An07g09530	Catalytic activity: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.; Complex: PDA1 of S. cerevisiae is a component of the multienzyme pyruvate dehydrogenase complex: this complex contains next to E1 also E2 (dihydrolipoamide acetyltransferase) and E3 (lipoamide dehydrogenase); the complex catalyzes the conversion of pyruvate to e. g. acetyl-CoA.; Pathway: PDA1 of S. cerevisiae takes part in the pyruvate metabolism, glycolysis and val/leu/ile biosynthesis.; Phenotype: the null mutant of PDA1 of S. cerevisiae is viable, but pyruvate dehydrogenase activity is lost and the mutant exhibits reduced growth on glucose and increased formation of petites.; Remark: PDA1 of S. cerevisiae is also called YER178w and PDHE1-A.; Similarity: the ORF shows strong similarity to PDA1 of S. cerevisiae, however, the N-terminal amino acids encoding the mitochondrial localization signal, are not included in the alignment.; Title: strong similarity to alpha subunit E1 of the pyruvate dehydrogenase complex Pda1 - Saccharomyces cerevisiae; See PMID 1330555; See PMID 2684159
An07g09540	Function: Piccolo of R. norvegicus is a component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release.; Similarity: the ORF shows local similarity to Piccolo of R. norvegicus: only one fourth of the ORF sequence and 1/25 of the Piccolo sequence is included in the alignment; evenmore, the aligned sequence is alanine,proline and glutamine rich.; Title: weak similarity to multidomain presynaptic cytomatrix protein Piccolo - Rattus norvegicus; See PMID 8900486; See PMID 11182086
An07g09550	Function: NAM9 of S. cerevisiae encodes for a mitochondrial ribosomal protein.; Phenotype: the null mutant of NAM9 of S. cerevisiae is viable but is respiration-deficient and loses mitochondrial DNA integrity.; Remark: NAM9 of S. cerevisiae is also called JTD486,N1211, N1840, and YNL137c.; Title: strong similarity to mitochondrial ribosomal protein Nam9 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9360714; See PMID 10982839; See PMID 1729612; See PMID 7557422
An07g09560	Function: uvsD of A. nidulans controlls mitotic intragenic recombination and recovery from UV damage.; Remark: uvsD of A. nidulans also causes a rereplication phenotype.; Title: strong similarity to cell cycle check point protein uvsD - Aspergillus nidulans; See PMID 10564263; See PMID 4945003; See PMID 4945004
An07g09570	Catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol.; Function: CDS1 of S. cerevisiae synthesizes CDP-diacylglycerol, and is thus involved in cell growth.; Pathway: CDS1 of S. cerevisiae takes part in the phospholipide biosynthesis.; Phenotype: null mutants of CDS1 of S. cerevisiae were incapable of spore germination or vegetative growth.; Remark: CDS1 of S. cerevisiae belongs to the CDS family.; Remark: CDS1 of S. cerevisiae is also called CDG1,and YBR029c.; Title: strong similarity to phosphatidate cytidylyltransferase Cds1 - Saccharomyces cerevisiae; See PMID 8557688; See PMID 8910557
An07g09580	Complex: cyclin K of H. sapiens interacts with the catalytic subunit of the transcription elongation factor P-TEFb, CDK9, in vivo.; Function: cyclin K of H. sapiens functions as a regulatory subunit of CDK9, a carboxy-terminal domain kinase acting on the largest subunit of RNA polymerase II.; Function: cyclin K of H. sapiens is a modulator of transcription activity.; Function: cyclin K of H. sapiens is able to complement G1 cyclin deficiency in S. cerevisiae.; Title: similarity to cyclin K CPR4 - Homo sapiens; See PMID 9632813; See PMID 10574912
An07g09590	Function: GST of patent US5962229-A is involved in the detoxification of herbicides and other xenobiotics.; Remark: shows homology to the protein from the patent database entry PATENTPROT:AAY40570.; Title: strong similarity to glutathione S-transferase GST from patent US5962229-A - Zea mays; See PMID 11080288
An07g09600	Function: FN3K of H. sapiens phosphorylates fructosamine substrates, such as fructoselysine,fructoseglycine or glycated lysozyme, at the third carbon hydroxyl of the fructose moiety.; Function: the physiological role of FN3K of H. sapiens may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins.; Title: strong similarity to fructosamine-3-kinase FN3K - Homo sapiens; See PMID 1101644
An07g09610	Similarity: contains a putative leucine zipper and an armadillo tandem repeat-like domain (Pfam: PF00514).; Title: strong similarity to hypothetical protein B24H17.130 - Neurospora crassa
An07g09630	Function: PREG of N. crassa regulates the activity of NUC-1, a transcriptional activator of phosphorus aquisition enzymes.; Similarity: belongs to the Pho80 family of cyclin-like proteins, to which particularly the C-terminal part shows strong homology.; Title: strong similarity to phosphorus acquisition transcriptional activator NUC-1 negative regulator PREG -Neurospora crassa; See PMID 8436269
An07g09650	Function: Chs7p of S. cerevisiae is involved in chitin synthase III (CSIII) export from the ER and consequently, in the regulation of CSIII activity.; Localization: Chs7p of S. cerevisiae is an integral membrane protein located in the ER.; Phenotype: in chs7 mutants of S. cerevisiae chitin synthase III (CSIII) is retained in the ER, leading to a severe defect in CSIII activity and consequently, to a reduced rate of chitin synthesis.; Remark: the ORF is C-terminally truncated due to end of contig.; Remark: the systematic gene name of CHS7 of S. cerevisiae is YHR142w.; Title: similarity to chitin synthase III like Chs7 -Saccharomyces cerevisiae [truncated ORF]; See PMID 10366589
An07g09680	Catalytic activity: 4-carboxymethylenbut-2-en-4-olide + H2O = 4-oxo-2-endioate (maleylacetate).; Function: EC 3. 1. 1. 45 catalyzed aromate degradation leads to maleylacetate, which is subsequently metabolized to TCA cycle substrates.; Function: EC 3. 1. 1. 45 is involved in the degradation of halogenated aromates, eg dichlorobenzene.; Similarity: belongs to the family of dienelactone hydrolases.; Title: strong similarity to hypothetical carboxymethylenbutenolide hydrolase YDL086w - Saccharomyces cerevisiae
An07g09690	Pathway: STS1 of S. pombe is involved in ergosterol biosynthesis.; Similarity: belongs to the ERG4/ERG24 family.; Title: strong similarity to sterol C-24(28) reductase sts1p - Schizosaccharomyces pombe; See PMID 8125337
An07g09700	Similarity: contains a RING-type (C3HC4) zinc finger domain typically associated with various transcription regulators.; Title: strong similarity to hypothetical RING zinc finger protein SPBP8B7.23 - Schizosaccharomyces pombe
An07g09710	Title: strong similarity to hypothetical conserved protein B1D4.270 - Neurospora crassa
An07g09720	Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical protein SPAC652.01 - Schizosaccharomyces pombe [truncated ORF]
An07g09730	Function: the S. cerevisiae homolog Ubp3p is a ubiquitin-specific protease.; Remark: Ubp3p of S. cerevisiae is controlling the activity or assembly of the SIR protein complex, which is involved in silencing of transcription at the silent mating type loci and at the yeast telomeres.; Similarity: belongs to family 2 of ubiquitin carboxyl-terminal hydrolases.; Title: strong similarity to ubiquitin specific protease Ubp3 - Saccharomyces cerevisiae
An07g09740	Function: ZrSOD2-22 of Z. rouxii CBS732 confers tolerance to toxic concentrations of Na(+) and Li(+) cations.; Function: ZrSOD2-22 of Z. rouxii CBS732 is a Na(+) efflux pump driven by the transmembrane H(+) gradient.; Title: strong similarity to Na(+)/H(+) antiporter ZrSOD2-22 - Zygosaccharomyces rouxii; See PMID 11403849
An07g09750	Catalytic activity: RNase H1 of M. musculus cleaves RNA-DNA hybrids at the RNA:DNA junction generating a 3'-hydroxyl-terminated oligoribonucleotide and a 5'-monophosphate-terminated polydeoxyribonucleotide.; Function: RNase H1 of M. musculus binds to dsRNA and RNA-DNA hybrids.; Function: RNase H1 of M. musculus degrades specifically RNA of RNA-DNA hybrids.; Function: a role of RNase H1 in the removal of RNA primers during lagging-strand DNA biosynthesis is proposed.; Title: strong similarity to ribonuclease (RNase) H1 Rnh1 - Mus musculus; See PMID 9799596; See PMID 10567561
An07g09760	Catalytic activity: bgln of C. molischiana catalizes the hydrolysis of terminal non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: bgln of C. molischiana is mainly involved in the degradation of various aromatic beta-glycosides, eg anthocyanin.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245
An07g09770	Title: similarity to hypothetical protein AAO31979.1 - Fusarium sporotrichioides
An07g09790	Title: similarity to hypothetical protein YKL051w -Saccharomyces cerevisiae
An07g09800	Function: VTC3 of S. cerevisiae is involved in the phosphate metabolism and its transcription is regulated by PHO system.; Remark: VTC3 of S. cerevisiae is also called LPB12C,YPL019C or PHM2.; Similarity: the ORf shows strong similarity to several putative polyphosphate synthetases.; Title: strong similarity to hypothetical polyphosphate synthase Vtc3 - Saccharomyces cerevisiae; See PMID 11102525
An07g09810	Remark: SPAC14C4. 10c of S. pombe is believed to be a member of the family of nudix hydrolases, and to function in hydrolysing nucleoside diphosphate derivatives.; Title: strong similarity to hypothetical protein SPAC14C4.10c - Schizosaccharomyces pombe
An07g09820	Title: similarity to hypothetical protein CAD21149.1 - Neurospora crassa
An07g09830	Title: strong similarity to hypothetical protein encoded by B19C19.110 - Neurospora crassa
An07g09840	Function: tetA of E. coli is an efflux transporter,which confers resistance to tetracycline.; Similarity: the ORF shows strong similarity to several membrane transporters from different species,especially to tetracycline resistance proteins.; Title: similarity to tetracyclin resistance protein tetA - Escherichia coli
An07g09850	Title: strong similarity to hypothetical protein B9J10.230 - Neurospora crassa
An07g09860	Function: sepB of A. nidulans is involved in chromosome segregation and the initiation of cytokinesis.; Remark: the predicted A. niger ORF is 55 amino acid longer at its C-terminus than sepB of A. nidulans.; Title: strong similarity to chromosome segregation protein sepB - Aspergillus nidulans
An07g09870	Catalytic activity: dihydroxy-acid dehydratases convert 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Function: dihydroxy-acid dehydratases are involvedin the biosynthesis of amino acids from the pyruvate family.; Remark: ILV3 of S. cerevisiae is also called YJR016C or J1450.; Similarity: the ORF shows strong similarity to dihydroxy-acid dehydratases from several bacteria.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945
An07g09880	Catalytic activity: CYP7 of O. cuniculus c catalyses cholesterol + NADPH + O(2) <=> 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.; Function: cholesterol 7alpha-monooxygenase is a key enzyme in a series of metabolic changes for the production of bile acids from cholesterol.; Title: similarity to cholesterol 7alpha-monooxygenase CYP7 - Oryctolagus cuniculus
An07g09890	Function: RNA12 of S. cerevisiae is involved in mitochondrial genome maintenance by controlling rRNA processing.; Phenotype: RNA12-1 is a dominant temperature-sensitive (Ts) S. cerevisiae mutant which has been reported to exhibit a defect in RNA accumulation at 37 degrees C.; Phenotype: inactivation of the S. cerevisiae nuclear gene RNA12 causes an increased rate of DNA escape from mitochondria to the nucleus.; Remark: RNA12 of S. cerevisiae is also called prp12,YME2 or YMR302C.; Title: strong similarity to pre-rRNA maturation protein Rna12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8649384
An07g09900	Similarity: the predicted ORF is 79 amino acids longer at the N-terminus than the hypothetical protein SPAC227. 17c of S. pombe.; Title: similarity to hypothetical protein CAD70286.1 - Neurospora crassa
An07g09910	Similarity: blastp matches are due to repetetive sequences.
An07g09920	Similarity: the ORF shows similarity to several glutamate synthases with different cofactor-requirements,represented by EC numbers 1. 4. 7. 1, 1. 4. 1. 14 and 1. 4. 1. 13.; Title: strong similarity to NADH-dependent glutamate synthase NADH-GOGAT - Medicago sativa; See PMID 8453303
An07g09940	Remark: no blast match was found.
An07g09960	Function: BET1 of S. cerevisiae is involved in ER to Golgi transport and retrograde (Golgi to ER) transport of proteins.; Phenotype: overexpression of BET1 in S. cerevisiae compensates for the loss of function of the ras-like GTP-binding protein Ypt1.; Remark: of S. cerevisiae is also called SLY12,YIL004C or YIA4C.; Title: strong similarity to v-SNARE Bet1 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 1396561
An07g09980	Remark: the predicted exon-intron structure of the ORF is not typical for A. niger proteins.
An07g09990	Function: the purified hsp70 of A. capsulata induces a cellular immune response in humans, probably due to the presence of peptide fragments/proteins copurified with the chaperone.; Function: the very conserved family of hsp70 proteins is involved in protein folding and assembling/disassembling of protein complexes in various cellular compartments.; Remark: the sequence of the predicted ORF was corrected, becauuse it contains two putative frameshifts due to possible sequencing errors at two different positions (in each case one nucleotide, probably 'G' was missing).; Similarity: the ORF overlaps with A. niger ESTs an_3500 (EMBLEST:BE759161) and an_3404 (EMBLEST:BE760676).; Title: strong similarity to heat shock protein 70 hsp70 - Ajellomyces capsulatus [putative frameshift]; putative frameshift
An07g10000	Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 119 amino acids long.; Title: questionable ORF
An07g10010	Function: YHM1 of S. cerevisiae is a multicopy suppressor of the temperature-sensitive defect associated with an abf2 null mutation lacking the HMG1-like mitochondrial DNA-binding protein HM, which is required for maintenance of the yeast mitochondrial genome.; Remark: YHM1 of S. cerevisiae is also called SHM1,YDL198C or D1214.; Similarity: the ORF overlaps witg A. niger EST an_3460, database entry EMBLEST:BE759135.; Title: strong similarity to mitochondrial carrier protein Yhm1 - Saccharomyces cerevisiae; See PMID 1990290
An07g10020	Function: AUT7 of S. cerevisiae is essential for an early step in autophagic and cytoplasma-to-vacuole (CVT) vesicle formation. it is also required for the attachment of these vesicles to microtubules.; Phenotype: S. cerevisiae AUT7 null mutants are viable but lack autophagocytosis and are unable to sporulate.; Remark: AUT7 of S. cerevisiae is also called APG8 or CVT5.; Remark: S. cerevisiae Aut7p interacts with the APG conguation system, a protein modification system similar to the ubiquitin conjugation pathway.; Similarity: the ORF shows also strong similarity to ganglioside expression factor 2 homologues/GABA-A receptor-associated.; Title: strong similarity to microtubule-associated protein Aut7 - Saccharomyces cerevisiae; cytoplasm; See PMID 9649430
An07g10040	Catalytic activity: HEM13 of S. cerevisiae catalyses coproporphyrinogen-III + O(2) <=> protoporphyrinogen-IX + 2 CO(2).; Function: HEM13 from S. cerevisiae catalyzes the sixth enzymic step in the heme biosynthetic pathway; coproporphyrinogen oxidases III are generally involved in the biosynthesis of porphyrins such as heme, chlorophyll or cobalamin.; Induction: the expression of HEM13 from S. cerevisiae is negatively regulated by heme and oxygen.; Phenotype: the loss of coproporphyrinogen oxidase activity by anaerobiosis in S. cerevisiae caused a considerable decrease of heme formation in anaerobic cells.; Title: strong similarity to coproporphyrinogen oxidase III Hem13 - Saccharomyces cerevisiae; cytoplasm; See PMID 2838478
An07g10050	Function: HOOK3 of H. sapiens is required for the maturation of multivesicular bodies, which are required for diverse membrane-trafficking events.; Phenotype: overexpression of HOOK3 in human cells caused fragmentation of the Golgi complex, therefore HOOK3 is believed to participate in defining the architecture and localization of the mammalian Golgi complex.; Similarity: the similarity of the ORF to HOOK3 of H. sapiens is restricted to the N-terminal part, which includes the conserved NH(2)-terminal domain characteristic for Hook proteins that mediates attachment to microtubules, whereas the more divergent COOH-terminal domain of HOOK3,which mediates the binding to organelles, shows no significant similarity to the ORF.; Title: strong similarity to golgi-associated microtubule-binding protein HOOK3 - Homo sapiens
An07g10060	Similarity: the ORF overlaps with A. niger ESTs an_2186 (EMBLEST:BE759383) and an_2334 (EMBLEST:BE759511).; Title: strong similarity to proteinase B inhibitor 2 Pbi2 - Saccharomyces cerevisiae; See PMID 2015812
An07g10070	Remark: A. niger EST from patent WO200056762-A2 has the database entry number PATENTDNA:AAF11649 (SEQ ID NO:4172).; Title: strong similarity to EST SEQ ID NO:4172 from patent WO200056762-A2 - Aspergillus niger
An07g10080	Function: PCF11 of S. cerevisiae directly contacts the phosphorylated carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II.; Function: PCF11 of S. cerevisiae is one of the five subunits of pre-mRNA cleavage/polyadenylation factor IA,which is necessary for RNA 3' end processing.; Title: strong similarity to RNA processing factor Pcf11 - Saccharomyces cerevisiae; See PMID 9223284; See PMID 11149954; See PMID 11344258
An07g10090	Catalytic activity: dimeric dihydrodiol dehydrogenases (= trans-1,2-dihydrobenzene-1,2-diol dehydrogenases) convert trans-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + NADPH.; Function: JMO2DD of M. fuscat has additionally to its 3-deoxyglucosone reductase function an activity of NADP-dependent D-xylose dehydrogenase (EC 1. 1. 1. 179).; Remark: JMO2DD of M. fuscata is also called CMO2DD.; Title: strong similarity to dimeric dihydrodiol dehydrogenase JMO2DD - Macaca fuscata; See PMID 10477285
An07g10100	Catalytic activity: adk1 of S. cerevisiae converts ATP + AMP <=> 2 ADP.; Function: adk1 of S. cerevisiae catalyzes the reversible phosphorylation of adenine monophosphate with adenosine triphosphate to form two adenosine diphosphates in the presence of magnesium, an essential reaction for many processes in living cells.; Remark: adk1 of S. cerevisiae is also called YDR226W, AKY2 or AKY1.; Title: strong similarity to adenylate kinase Adk1 -Saccharomyces cerevisiae
An07g10110	Function: the regulatory particel of the 26S proteasome covers the presumed channels leading into the interior of the core particle and is required for the entry of substrates into the proteasome core.; Similarity: the ORF shows strong similarity to homologues of the rpn12 protein from different species, but also to another 26S proteasome regulatory protein, rnp8 of S. cerevisiae.; Title: strong similarity to 26S proteasome regulatory chain 12 rpn12 - Homo sapiens; See PMID 9584156
An07g10120	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: weak similarity to hypothetical protein CAD21232.1 - Neurospora crassa
An07g10130	Catalytic activity: ubiquitin-specific processing proteases catalyse ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.; Function: DUB-1 of M. musculus is a thiol protease,that recognizes and hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin and are by this involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.; Function: DUB-1 of M. musculus is an enzyme of the ubiquitin system directly implicated in cytokine-regulated growth control by integrating extracellular signals with cellular growth and cell cycle progression, and in cytokine-induced cell proliferation.; Induction: DUB-1 of M. musculus is induced by interleukin (IL-3).; Remark: DUB-1 of M. musculus is also called deubiquitinating enzyme, ubiquitin carboxy-terminal hydrolase or ubiquitin thiolesterase.; Similarity: the ORF shows weak similarity to some ubiquitin-specific proteinases from different species.; Similarity: the similarity of the ORF to DUB-1 of M. musculus is locally high in the N-terminus, ending with amino acid 400 of the ORF, but importantly, the cystein at position 60 and the histidine residues at positions 298/307 of DUB-1 from M. musculus, which are probably implicated in the catalytic mechanism, are present in the predicted ORF.; Title: weak similarity to ubiquitin specific processing protease DUB1 - Mus musculus; See PMID 8622927
An07g10140	Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 147 amino acids long.; Title: questionable ORF
An07g10150	Remark: the predicted ORF has an exon-intron structure, which is not typical for A. niger proteins.
An07g10160	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 118 amino acids.; Title: questionable ORF
An07g10170	Remark: the ORF is questionable due its short lenght of only 109 amino acids.; Title: questionable ORF
An07g10180	Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 117 amino acids long.; Title: questionable ORF
An07g10190	Remark: the expansion of CAG repeats is characteristic for the DRPLA protein of e. g. H. sapiens,which leads to the dentatorubral and pallidoluysian atrophy (DRPLA), an autosomal dominant neurodegenerative disorder.; Remark: the lenght of the predicted ORF (293 amino acids) and the high similarity to the DRPLA related protein of N. crassa, which is 538 amino acids long, suggests that the predicted A. niger homolog has an wrong stop codon; it is assumed that the right stop codon was cut due to contig border.; Title: strong similarity to hypothetical DRPLA related protein - Neurospora crassa; See PMID 8852663
An07g10200	Title: strong similarity to hypothetical protein SPAC13D6.03c - Schizosaccharomyces pombe
An07g10210	Function: CKAP1 of H. sapiens binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.; Similarity: CKAP1 of H. sapiens belongs to the ckap1/alp11 subfamily.; Title: strong similarity to tubulin folding cofactor B CKAP1 - Homo sapiens; See PMID 9265649
An07g10220	Title: similarity to hypothetical neurofilament triplet H1 related protein B3E4.50 - Neurospora crassa
An07g10230	Catalytic activity: endonucleolytic cleavage to 5'-phospho-monoester.; Function: RNase H specifically cleaves a RNA base-paired to a complementary DNA strand.; Remark: RNH35 of S. cerevisiae is also called YNL072w.; Title: strong similarity to ribonuclease HI large subunit Rnh35 - Saccharomyces cerevisiae; See PMID 9462832
An07g10240	Localization: Pex16 of Y. lipolytica is a peripheral protein located at the matrix face of the peroxisomal membrane.; Phenotype: Pex16 mutants in Y. lipolytica are defective in peroxisome assembly.; Phenotype: mutation of Pex16 in humans causes a form of Zellweger syndrome, a disease due to defective import of peroxisomal matrix proteins.; Title: strong similarity to peroxisomal membrane protein peroxin-16 pex-16 - Yarrowia lipolytica; peroxisome; See PMID 9182661; See PMID 9922452
An07g10250	Function: SAE2 of S. cerevisiae is involved in meiotic recombination and chromosome metabolism.; Remark: SAE2 of S. cerevisiae is also known as COM1 or YGL175C.; Similarity: the similarity to SAE2 of S. cerevisiae is due only to a very short, but very conserved, amino acid stretch.; Title: weak similarity to protein Sae2 -Saccharomyces cerevisiae; See PMID 9215888; See PMID 11333222
An07g10260	Remark: Fbxw6 from mouse seems to be part of a ubiquitin protein ligase.; Title: weak similarity to F-box-WD40 repeat protein Fbxw6 - Mus musculus
An07g10270	Function: byr3 of S. pombe acts in the sexual differentiation pathway, and is required for efficient conjugation.; Function: byr3 of S. pombe is a double stranded DNA-binding protein.; Similarity: A. niger EST EMBLEST:BE758932 contains exons 6 and 7, and part of the putative 3'UTR.; Similarity: byr3 of S. pombe is similar to human CNBP and to retroviral nucleic acid binding proteins (NBP).; Similarity: the predicted protein, as well as S. pombe byr3, contains typical Zinc finger motifs called Zinc knucles; the zinc knuckle is a zinc binding motif composed of 18 residues, mainly found in the nucleocapsid protein of retroviruses, where it is required for viral genome packaging and for early infection process; it is also found in eukaryotic proteins involved in RNA or DNA binding.; Title: strong similarity to cellular nucleic acid binding protein byr3p - Schizosaccharomyces pombe; See PMID 1515675
An07g10280	Title: strong similarity to hypothetical protein B17C10.170 - Neurospora crassa
An07g10290	Similarity: A. niger EST EMBLEST:BE758817 corresponds to exon 3 and part of the putative 3'UTR of the gene.; Similarity: the predicted protein shows strong similarity to many hypothetical members of the aldo/keto reductase family, which includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase,xylose reductase, rho crystallin, and many others.; Title: strong similarity to MP protein sequence SEQ ID NO:860 from patent WO200100843-A2 - Corynebacterium glutamicum; See PMID 2498333
An07g10310	Title: weak similarity to PPAR gamma coactivator PGC-1 - Mus musculus; See PMID 9529258
An07g10320	Title: strong similarity to hypothetical conserved protein B13I18.30 - Neurospora crassa
An07g10340	Gene-ID: srgD; Similarity: the C-terminal part of the predicted protein is almost identical to an A. niger partial mRNA for a secretion related GTPase; the GTPase is called SrgD, but it was not published, and is poorly characterized.; See PMID 11489135
An07g10350	Catalytic activity: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosyl-protein.; Gene-ID: pmtA; Pathway: glycosylation.; Remark: the matching sequence of pmtA from A. niger was found by a BLAST search against the new EMBL entry AAK77607.; Similarity: the predicted ORF is almost identical to A. nidulans pmtA that was recently cloned, but not yet published.
An07g10360	Remark: the ORF is classified as questionable because it partially overlaps to A. niger EST EMBLEST:BE759972, which might represent the 5'UTR of the following gene model caut. 00. tfa_40wk.; Title: questionable ORF
An07g10370	Function: HGT1 of K. lactis is an high affinity glucose transporter.; Similarity: HGT1 of K. lactis belongs to the sugar transporter family.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An07g10380	Title: questionable ORF
An07g10390	Remark: SFC1 of S. cerevisiae is also called ACR1 or YJR095W.; Title: weak similarity to succinate-fumarate transport protein Sfc1 - Saccharomyces cerevisiae; See PMID 7908717
An07g10395	Title: strong similarity to hypothetical protein EAA62284.1 - Aspergillus nidulans
An07g10400	Complex: CDC68 of S. cerevisiae interacts with Pob3 to form the CP complex.; Function: CDC68 of S. cerevisiae is an essential nuclear protein required for gene activation and also chromatin-mediated repression.; Remark: CDC68 of S. cerevisiae is also known as SPT16 or YGL207W.; Title: strong similarity to cell division control protein Cdc68 - Saccharomyces cerevisiae; nucleus; See PMID 7565755; See PMID 7935460; See PMID 8246972; See PMID 1833637; See PMID 1922073
An07g10410	Title: strong similarity to metalloprotease Mep1 -Metarhizium anisopliae; See PMID 8053668
An07g10420	Function: cdc50-1 mutant arrests at START in G1 phase at the non-permissive temperature.; Phenotype: CDC50 mutants in S. cerevisiae are cold sensitive, sensitive to trifluoperazine, ZnCl2, CoCl2 and MnCl2.; Remark: CDC50 of S. cerevisiae is also called YCR094w.; Title: strong similarity to cell division cycle protein Cdc50 - Saccharomyces cerevisiae; See PMID 6749598; See PMID 11180453
An07g10430	Remark: FUN19 of S. cerevisiae is also called YAL034C.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein Fun19 - Saccharomyces cerevisiae
An19g00010	Title: similarity to hypothetical protein CAD60780.1 - Podospora anserina
An19g00030	Title: similarity to hypothetical protein At2g14560 - Arabidopsis thaliana
An19g00040	Title: weak similarity to hypothetical protein encoded by An15g06860 - Aspergillus niger
An19g00050	Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa
An19g00060	Title: strong similarity to hypothetical protein SMb20006 - Sinorhizobium meliloti
An19g00080	Similarity: the predicted A. niger protein shows similarity to domains of ankyrin.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021
An19g00090	Catalytic activity: Cmg1 catalyzes the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: the 1,3-beta-glucosidase Cmg1 from Coniothyrium minitans is involved in cell wall degradation of the host fungi.; Remark: during sclerotial infection of Sclerotinia sclerotiorum the mycoparasite Coniothyrium minitans penetrates through the host cell wall.; Title: strong similarity to exo-beta-1,3-glucanase Cmg1 - Coniothyrium minitans; extracellular/secretion proteins; See PMID 11157256
An19g00100	Catalytic activity: hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Similarity: the ORF encoded protein shows strongest similarity to the chitinase ChiC from Aspergillus nidulans which is still unpublished.; Title: similarity to chitinase Eh cht1 - Entamoeba invadens; See PMID 9106188
An19g00110	Title: similarity to hypothetical protein encoded by An12g05110 - Aspergillus niger
An19g00120	Function: the AKT2 gene from Alternaria alternata encodes a protein of unknown function, which is essential for AK-toxin production and pathogenicity.; Remark: the Japanese pear pathotype of Alternaria alternata causes black spot of Japanese pear by producing a host-specific toxin known as AK-toxin.; Title: similarity to protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635; See PMID 10975654
An19g00130	Remark: alternate name for S. cerevisiae Hxt2: YMR011w.; Repression: high concentrations of glucose lead to the redistribution of S. cerevisiae HEX2 to the vacuole.; Repression: low-glucose-induced expression of S. cerevisiae HEX2 is mediated by two independent repression mechanisms, in the absence of glucose, transcription is prevented by Rgt1p, a C6 zinc cluster protein; at high levels of glucose, expression is repressed by Mig1p.; Title: similarity to glucose transport protein Hxt2 - Saccharomyces cerevisiae [putative frameshift]; plasma membrane; putative frameshift; See PMID 8816466; See PMID 10191260
An19g00140	Catalytic activity: Carnitine + NAD(+) <=> 3-dehydrocarnitine + NADH.; Title: strong similarity to carnitine dehydrogenase from patent JP05161492-A - Alcaligenes sp.
An19g00150	Function: formyl-CoA transferase of O. formigenes transfers a CoA moiety from formyl-CoA to oxalate to activate oxalic acid.; Remark: oxalic acid is a highly toxic by-product of metabolism, which is catabolized by a limited number of bacterial species.; Similarity: the ORF and formyl-CoA transferase of O. formigenes show local N-terminal similarity (along a stretch of about 200 amino acids).; Similarity: the ORF is shorter than formyl-CoA transferase of O. formigenes (339 compared to 428 amino acids).; Similarity: the ORF shows also similarity to (putative) racemases or transferases of other species.; Title: similarity to formyl-CoA transferase from patent WO9816632-A1 - Oxalobacter formigenes; See PMID 9150242; See PMID 2361939
An19g00160	Function: facB of A. nidulans is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (facA), isocitrate lyase (acuD) and malate synthase (acuE).; Remark: facB of A. nidulans is a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain.; Similarity: the ORF is shorter than facB of A. nidulans (668 compared to 867 amino acids).; Similarity: the ORF shows local N-terminal similarity with facB of A. nidulans (over a stretch of about 300 amino acids).; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126
An19g00170	Function: LRP5 of H. sapiens binds apolipoprotein E (apoE).; Function: LRP5 of H. sapiens is a low density lipoprotein receptor (LDLR)-related protein.; Remark: LRP5 of H. sapiens is genetically associated with Type 1 diabetes.; Remark: LRP5 of H. sapiens shows similarity to the low density lipoprotein receptor class A (LDLRA) domain.; Similarity: the ORF is much shorter than LRP5 of H. sapiens (308 compared to 1615 amino acids).; Similarity: the ORF shows local similarity to LRP5 of H. sapiens over a C-terminal stretch of about 190 amino acids.; Title: similarity to low density lipoprotein receptor related protein LRP5 from patent WO9846743-A1 -Homo sapiens; See PMID 9832610; See PMID 10990489
An19g00180	Function: DAL5 of S. cerevisiae is an integral membrane protein, transporting allantoate via the plasma membrane.; Phenotype: disruption of DAL5 of S. cerevisiae leads to viable cells, unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614
An19g00200	Title: strong similarity to hypothetical protein 99H12.80 - Neurospora crassa [putative sequencing error]; putative sequencing error
An19g00210	Function: hemolysin of A. fumigatus is a cytolytic toxin, lytic for erythrocytes of humans, rabbits and sheep.; Remark: hemolysin of A. fumigatus is inactivated by the addition of serum or blood plasma.; Similarity: the ORF overlaps with A. niger ESTs (e. g. an_3635 in EMBLEST:BE759282, an_2964 in EMBLEST:BE760009, an_3529 in EMBLEST:BE759189, NO:4040 in PATENTDNA:AAF11517, and NO:4110 in PATENTDNA:AAF11587).; Title: similarity to hemolysin ASP-HS - Aspergillus fumigatus; See PMID 8086452; See PMID 11433776
An19g00220	Remark: the predicted ORF contains relatively long introns.
An19g00230	Catalytic activity: thyrosinases catalyse L-tyrosine + L-DOPA + O(2) <=> L-DOPA + DOPAquinone + H(2)O.; Function: melC of S. antibioticus is a thyrosinase,which binds copper and functions in the formation of pigments such as melanins and other polyphenolic compounds.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE760551) an_1878.; Similarity: the similarity of the ORF to mel of S. antibioticus is restricted to the C. terminus of the ORF,starting which amino acid 158, with is homologues to amino acid 1 of the S. antibioticus protein.; Title: similarity to monophenol monooxygenase melC2 - Streptomyces antibioticus; See PMID 2107124
An19g00240	Title: strong similarity to hypothetical protein encoded by An17g00130 - Aspergillus niger
An19g00250	Remark: the predicted ORF contains relatively long introns.
An19g00260	Remark: the ORF shows local similarity to a short stretch of 101 bases to the published A. niger pectin lyase D gene sequence (probably the 5' untranslated region),which is located 3' to this ORF (100wg).
An19g00270	Function: the A. niger pectin lyase D gene serves in a expression system for recombinant proteins in A. niger,which can be induced by adding pectin to the culture medium.; Gene-ID: pelD; Remark: pelD was previously described as pectin lyase I (Van Houdenhoven, Ph. D. Thesis, Wageningen,1975).; Remark: the ORF sequence differs at amino acid 10 (I10V) from the published database sequence (PIR:JH0155).
An19g00280	Remark: the N-terminus of the ORF overlaps with the published sequence of the pelD gene of A. niger, probably the 3' untranslated region.; Similarity: the predicted ORF overlaps with the C-terminal region of the putative D. melanogaster protein CG12065, but is 303 amino acids shorter at the N-terminus.; Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster
An19g00290	Function: human PDGH catalyzes the oxidation of many prostaglandins at C-15, resulting in a subsequent reduction in their biological activity.; Similarity: the a. niger protein shows similarity to several prostaglandin dehydrogenases and 3-oxoacyl-(acyl-carrier protein) reductases.; Title: similarity to NAD+-dependent 15-hydroxyprostaglandin dehydrogenase PDGH - Homo sapiens; See PMID 1697582
An19g00300	Function: Kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli, the light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.; Remark: the A. niger protein shows similarity to kinesin light chains of different organisms.; Title: strong similarity to kinesin light chain KLC - Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346
An19g00320	Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289
An19g00330	Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289
An19g00340	Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289
An19g00350	Function: pmc1 of S. cerevisiae pumps Ca2+ into the vacuole and participates in the control of the cytosolic free calcium together with atc1 protein.; Phenotype: mutations in calcineurin A or B subunits or the inhibitory compounds FK506 and cyclosporin A restore growth of pmc1 mutants in high Ca2+ media.; Remark: alternate names for pmc1 of S. cerevisiae are G3749 or YGL006w.; Repression: the growth of S. cerevisae pmc1 mutants is inhibited by added Ca2+ only after activation of calcineurin.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae; vacuole; See PMID 7507493
An19g00360	Title: similarity to hypothetical protein encoded by An08g05310 - Aspergillus niger
An19g00370	Title: similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger
An19g00380	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Similarity: the ORF encoded protein shows similarity to many hypothetical flavoprotein oxidoreductases. The similarity of the ORF encoded protein to the 6-hydroxy-D-nicotine oxidase 6-HDNO from A. oxidans only concerns the N-terminal protein part.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516
An19g00390	Function: verA of A. nidulans catalyzes the conversion of versicolorin a to sterigmatocystin.; Pathway: verA of A. nidulans catalyzes a step in the sterigmatocystin synthesis pathway.; Remark: the A. niger protein shows similarity to different reductases.; Similarity: verA of A. nidulans belongs to the short-chain dehydrogenases/reductases family (SDR).; Title: strong similarity to versicolorin reductase verA - Aspergillus nidulans; See PMID 8017929; See PMID 8643646
An19g00400	Title: weak similarity to suppressor of cdc25 mutations Tfs1 - Saccharomyces cerevisiae
An19g00410	Title: strong similarity to hypothetical protein SA2438 - Staphylococcus aureus
An19g00420	Remark: YBR180w is the systematic name for S. cerevisiae DTR1.; Remark: information regarding S. cerevisiae DTR1 has not yet been published and is available via http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: S. cerevisiae DTR1 belongs to the major facilitator family of transport proteins.; Title: strong similarity to dityrosine transporter Dtr1 - Saccharomyces cerevisiae; See PMID 8720066
An10g00010	Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases require Zn for their activity, and use NAD or NADP as electron exchangers.; Similarity: adhB of T. ethanolicus belongs to the zinc-containing alcohol dehydrogenase family.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol and aldehyde dehydrogenases, with very wide substrate specificities.; Title: strong similarity to alcohol dehydrogenase (NADP+) adhB - Thermoanaerobacter ethanolicus; See PMID 8645192
An10g00020	Function: A. oligospora is a nematophagous fungus; the surface lectin is involved in capture of the worms.; Function: lectins in general are proteins which specifically bind or crosslink carbohydrates.; Function: the surface lectin of A. oligospora shows haemagglutinating activity inhibited by the glycoproteins mucin and fetuin.; Localization: the protein is soluble and secreted,and remains associated with extracellular polymer layers and with the cell wall of the fungus.; Title: similarity to hemagglutinating surface lectin - Arthrobotrys oligospora; extracellular/secretion proteins; See PMID 1487732; See PMID 8706686
An10g00030	Remark: similarity to C. glutamicum patented sequence and to other hypothetical proteins, which are all longer of the predicted ORF, and the position at the contig border, suggest that this could be a N-terminally truncated gene model.; Title: similarity to sequence 211 from patent WO0100842 - Corynebacterium glutamicum [truncated ORF]
An10g00040	Function: the protein of sequence 211 from Patent WO0100842 is involved in homeostasis and adaptation.; Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: shows similarity to several proteins homologous to N-benzoylamino-acid amidohydrolase (EC 3. 5. 1. 32; hippurate hydrolase) and/or similar amino-/amidohydrolases.; Title: strong similarity to sequence 211 from patent WO0100842 - Corynebacterium glutamicum [truncated ORF]
An10g00050	Function: Flu1p of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Similarity: the N-terminus appears about 120aa shorter than in FLU1 of C. albicans.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An10g00060	Function: aflR of A. sojae is involved in the regulation of aflatoxin biosynthesis.; Similarity: shares a fungal-type Zn(2)-Cys(6) binuclear cluster with a number of proteins involved in transcriptional regulation.; Title: weak similarity to transcription regulator aflR - Aspergillus sojae
An10g00070	Catalytic activity: 2 sulfhydryl groups + O2 = disulphide + H2O2.; Function: SOX of A. niger is a FAD-linked oxidoreductase containing redox-active disulphide centres.; Function: SOX of A. niger is involved in the formation of disulphide bounds, eg in proteins.; Remark: possible sequencing error at position 5789 leading to a frameshift.; Similarity: also shows similarity to various NADH oxidases.; Similarity: also shows similarity to various thioredoxin reductases and alkyl hydroperoxide reductases involved in oxidative stress response.; Similarity: belongs to the pyridine nucleotide-disulphide oxidoreductase class-II family.; Title: strong similarity to sulphydryl oxidase Sox from patent EP565172-A1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 3427078
An10g00090	Similarity: to cDNA patent PATENTDNA:A27119.; Title: weak similarity to NADP-specific glutamate dehydrogenase from patent WO200028006-A2 - Glycine max
An10g00100	Function: amdR of A. oryzae activates genes necessary for the catabolism of certain amids and lactams and for the utilization of omega-amino acids, eg GABA.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021
An10g00110	Catalytic activity: ordA of A. parasiticus converts O-methylsterigmatocystin and dihydro-O-methylsterigmatocystin to aflatoxins B1 or G1 and B2 or G2, respectively.; Pathway: ordA of A. parasiticus is required for the biosynthesis of aflatoxins B1, G1, B2, and G2.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: ordA of A. parasiticus belongs to the CYP64 family of cytochromes P-450.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus; See PMID 9835571; See PMID 10473388
An10g00120	Catalytic activity: 2,3-dihydroxybenzoic acid + H2O = catechol + HCO3(-).; Function: useful for production of catechol and related aromatic hydrocarbons.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger
An10g00130	Catalytic activity: 4-hydroxibenzoic acid + polyprenyl-diphosphate = 3-polyprenyl-4-hydroxybenzoic acid + pyrophosphate.; Pathway: ppt1 of S. pombe catalyzes the condensation of para-hydroxybenzoate and polyprenyl diphosphate in ubiquinone biosynthesis.; Title: strong similarity to para-hydroxybenzoate--polyprenyltransferase ppt1p -Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 11092853
An10g00140	Pathway: atX of A. terreus is required for the biosynthesis of the polyketide 6-methylsalicylic acid.; Similarity: belongs to the family of fungal MSAS-type polyketide synthases.; Similarity: contains the beta-ketoacyl synthase catalytic domain, the acyl transferase domain and phosphopantetheine attachment site of polyketide synthases.; Title: strong similarity to 6-methylsalicylic acid synthase atX - Aspergillus terreus; See PMID 9003280; See PMID 10361035
An10g00150	Function: TRI4 of M. roridum is a cytochrome P450-type monooxygenase.; Pathway: TRI4 of M. roridum catalyzes the initial oxygenation step in the biosynthesis pathway of trichothecene toxin.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 9529523
An10g00170	Catalytic activity: alcohol + NAD(P)(+) = corresponding aldehyde or keton + NAD(P)H + H(+).; Function: many SCAD family members are involved in steroid metabolism.; Similarity: belongs to the superfamily of short chain alcohol dehydrogenases (SCAD).; Title: strong similarity to protein sequence 79 from patent WO0129221 - Homo sapiens
An10g00180	Title: weak similarity to hypothetical protein encoded by An02g10900 - Aspergillus niger
An10g00190	Function: CHO of patent WO9931990-A1 oxidizes the reducing end of oligosaccharides with preference over the corresponding monosaccharides.; Title: similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale
An10g00220	Title: similarity to hypothetical protein CAE07943.1 - Synechococcus sp.
An10g00230	Catalytic activity: formaldehyde + NAD(+) + H2O = formate + NADH.; Function: at high pH, fdhA of P. putida catalyses the oxidation of long-chain alcohols.; Function: fdhA of P. putida converts formaldehyde to formate.; Function: fdhA of P. putida requires zinc for it's activity.; Function: the activity of fdhA of P. putida is independent of reduced glutathione.; Similarity: belongs to the zinc-containing long-chain alcohol dehydrogenase family.; Title: strong similarity to glutathione-independent formaldehyde dehydrogenase fdhA - Pseudomonas putida; See PMID 8169197
An10g00240	Title: weak similarity to hypothetical protein T8P19.230 - Arabidopsis thaliana
An10g00250	Function: Cos1p of C. albicans is a two-component histidine kinase probably involved in nutrient deprivation response.; Function: Cos1p of C. albicans is involved in hyphal morphogenesis and probably plays a role in virulence properties of the organism.; Similarity: COS1 of C. albicans is identical to CaNIK-1.; Title: strong similarity to histidine kinase COS1 -Candida albicans; See PMID 9618540
An10g00260	Title: strong similarity to EST an_1399 -Aspergillus niger
An10g00280	Similarity: the predicted A. niger protein shows similarity to part of several DNA-binding proteins and contains a DNA-binding-protein motif.; Title: weak similarity to zinc-finger transcription factor WRKY1 - Petroselinum crispum
An10g00290	Similarity: the predicted A. niger protein shows similarity to a putative alpha-L-rhamnosidase from C. crescentus and weak similarity to V. cholerae beta-galactosidase.; Title: similarity to hypothetical protein SCF34.07 -Streptomyces coelicolor
An10g00300	Function: S. cerevisiae Mal1 is a complex genetic locus giving rise to hexose transporter Isoforms of different specifity, namely a maltose specific Isoforme,MAL11 and a general alpha-glucoside transporting Isomforme,AGT1.; Remark: the predicted A. niger protein might be alternatively spliced.; Remark: the systematic name for S. cerevisiae MAL11 isYGR289C, an alias is AGT1.; Title: similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329; See PMID 1999393
An10g00310	Function: Iron and Copper uptake in S. cerevisiae involves at least two steps, reduction of ferric to ferrous ions extracellularly by the membrane-associated ferric reductases FRE1 and FRE2, and transport of the reduced ions through the plasma membrane.; Regulation: S. cerevisiae FRE2 expression, like FRE1 expression, is induced by iron and copper deprivation, and at least part of this control takes place at the transcriptional level mediated by Mac1.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 8164662; See PMID 10341420
An10g00320	Similarity: the predicted A. niger protein shows similarity to several hypothetical acetyltransferases and contains an acetyltransferase domain.; Title: strong similarity to hypothetical protein PA5433 - Pseudomonas aeruginosa
An10g00330	Catalytic activity: dihydrodipicolinate synthases convert L-aspartate 4-semialdehyde + pyruvate to dihydrodipicolinate + 2 H(2)O.; Function: C. glutamicum dapA is involved in lysine biosynthesis.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8092856; See PMID 2129555
An10g00340	Function: M. grisea pth11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Pathway: in M. grisea multiple signaling pathways mediate induction of appressorium differentiation by pth11.; Title: similarity to PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An10g00350	Catalytic activity: GTP cyclohydrolases II convert GTP + 3 H(2)O to formate + 2,5-diamino-6-hydroxy-4-(5-CA-phosphoribosylamino)pyrimidi ne + diphosphate.; Function: A. pleuropneumoniae ribA is involved in the riboflavin metabolism.; Title: similarity to GTP cyclohydrolase II ribA -Actinobacillus pleuropneumoniae; See PMID 8522537; See PMID 10940330
An10g00360	Complex: in S. cerevisiae, a fraction of the Dbp5 protein associates with nuclear pore complexes (NPCs) on the cytoplasmic side.; Function: Dbp5 of S. cerevisiae is an RNA-dependent ATPase which participates in the export of mRNAs out of the nucleus.; Remark: the alternate name of Dbp5 in S. cerevisiae is RAT8.; Similarity: the protein is closely related to eukaryotic initiation factor 4A(eIF4A).; Title: strong similarity to nuclear pore-associated DEAD-box protein Dbp5 - Saccharomyces cerevisiae; nucleus; See PMID 9564048; See PMID 10428971
An10g00370	Function: CIP4 is a downstream target of activated GTP-bound Cdc42, and is similar in sequence to proteins involved in signalling and cytoskeletal control in human.; Function: CIP4 of human is regulating the assembly of the actin cytoskeleton.; Similarity: also C-terminally similarities to a protein contains two SH3 domains and a phorbol esters/diacylglycerol binding domain.; Title: similarity to Cdc42-interacting protein 4 CIP4 - Homo sapiens; See PMID 9210375
An10g00380	Similarity: the central part of the protein shows some weak similarity to clathrin assembly protein AP180 of Xenopus laevis due to alanine-rich regions.
An10g00390	Catalytic activity: cellobiose + O(2) = cellobiono-1, 5-lactone + H(2)O(2).; Function: the biological function of CDH is not fully understood, but recent results support a hydroxyl radical-generating mechanism whereby the radical can degrade and modify cellulose, hemicellulose and lignin.; Remark: CDH has found technical use in highly selective amperometric biosensors and several other applications have been suggested.; Title: strong similarity to cellobiose dehydrogenase CDH - Phanerochaete chrysosporium; extracellular/secretion proteins; See PMID 8919793; See PMID 10725534; See PMID 11063597
An10g00400	Function: glycosylphosphatidylinositol-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall.; Similarity: strong similarity to beta(1-3)glucanosyltransferase BGT2 of A. fumigatus,patentnumber WO9808937-A1.; Title: strong similarity to 1,3-beta-glucanosyltransferase gel1 - Aspergillus fumigatus; See PMID 10769178; See PMID 10809732
An10g00410	Title: weak similarity to UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV - Homo sapiens
An10g00420	Title: weak similarity to 2-5A-dependent ribonuclease RNS4 - Homo sapiens
An10g00430	Complex: S. cerevisiae cell adhesion protein a-agglutinin is composed of an anchorage subunit (Aga1p) and an adhesion subunit (Aga2p).; Function: mating type-specific agglutination of S. cerevisiae a and alpha cells depends on the heterophilic interaction of two cell surface glycoproteins, the gene products of AG alpha 1 and AGA2.; Remark: truncated ORF due to the contig end.; Similarity: the BLASTp matches are mainly due to the serine-rich motif.; Title: strong similarity to agglutinin core protein Aga1 - Saccharomyces cerevisiae [truncated ORF]; cell wall; See PMID 2072914; See PMID 7770047; See PMID 7957044
An10g00440	Function: Nth-Spo possesses glycosylase activity on different types of DNA substrates with pyrimidine damage,being able to release both urea and thymine glycol from double-stranded polymers.; Remark: nth1 and SPAC30D11. 07 are alternative names for the nth-Spo gene; Title: strong similarity to endonuclease III nth-Spo - Schizosaccharomyces pombe; See PMID 8811082
An10g00460	Function: Smubp-2 DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region.; Function: Smubp-2 preferentially binds to the motif (5'-gggct-3'). stimulates the transcription of the human neurotropic virus JVC.; Remark: glial factor-1, gf-1 and DNA helicase are alternative names for Smubp-2.; Remark: the ORF encoded protein also shows strong similarity to several helicases and nonsense-mediated RNA decay.; Similarity: Smubp-2 belongs to the DNA2/NAM7 helicase family.; Title: strong similarity to Ig mu chain switch region binding protein 2 Smubp-2 - Homo sapiens; nucleus; See PMID 8349627; See PMID 10049831
An10g00470	Title: weak similarity to hypothetical extensin-like protein - Arabidopsis thaliana
An10g00480	Title: similarity to hypothetical GPI-anchor biosynthesis protein PIG-F related protein CAD70892.1 -Neurospora crassa
An10g00490	Title: similarity to hypothetical RhoGAP GTPase activating protein - Schizosaccharomyces pombe
An10g00500	Title: strong similarity to essential protein SEQ ID NO:7288 from patent WO200253728-A2 - Candida albicans
An10g00510	Catalytic activity: as ADH catalyzes the oxidation of primary and secondary alcohols to aldehydes and ketones,respectively, by NAD+; as FDH catalyzes the oxidation by NAD+ of formaldehyde and glutathione to S-formylglutathione.; Function: SFA1 is responsible for resistance to formaldehyde in S. cerevisiae.; Remark: belongs to the class III alcohol dehydrogenases which are not very active toward ethanol.; Title: strong similarity to alcohol dehydrogenase Sfa1 - Saccharomyces cerevisiae; See PMID 8483449
An10g00520	Function: ACC deaminase degrades ACC to 2-oxobutyrate and ammonia.; Remark: C-terminally truncated due to contig border.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate (ACC) deaminase ACD -Penicillium citrinum [truncated ORF]; See PMID 10737185
An10g00530	Catalytic activity: D-glucose 6-phosphate <=> 1L-myo-inositol 1-phosphate.; Pathway: the myo-inositol-1-phosphate synthase from Arabidopsis thaliana is involved in the synthesis of the important membrane component phosphatidyl-inositol (PI).; Title: strong similarity to myo-inositol-1-phosphate synthase INO1 - Arabidopsis thaliana; See PMID 8058832
An10g00540	Complex: the human hic-5 protein forms a complex with the cell adhesion kinase beta (CAKbeta/PYK2), which is the second protein-tyrosine kinase of the focal adhesion kinase subfamily.; Title: similarity to protein Hic-5 - Homo sapiens; See PMID 9422762
An10g00560	Induction: the mRNA of the Aspergillus nidulans hypothetical protein BinA is induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans; See PMID 10376827
An10g00570	Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532 - Unclassified organism
An10g00590	Remark: the KLP2 (=kinesin-like protein) protein from X. laevis is localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase.; Similarity: the ORF encoded protein shows a weak similarity to KLP2 (X. n.) with an e-val. of 0. 059.; Title: weak similarity to protein KLP2 - Xenopus laevis; See PMID 8548825
An10g00600	Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An10g00620	Remark: the ToxF gene product from Cochliobolus carbonum is involved in production of the cyclic tetrapeptide HC-toxin, which is required for pathogenicity of the filamentous fungus Cochliobolus carbonum on maize.; Title: strong similarity to hypothetical branched-chain amino acid aminotransferase ToxF -Cochliobolus carbonum; See PMID 10627051
An10g00630	Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH<=>a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Title: strong similarity to alpha subunit of the fatty acid synthase fasA - Aspergillus nidulans; See PMID 8848053; See PMID 8962148
An10g00650	Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH<=>a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans; See PMID 8848053; See PMID 8962148
An10g00660	Pathway: the TRI11 gene product from F. sporotrichioides is involved in the trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of gene from Fusarium sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: the TRI11 gene product from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An10g00670	Title: similarity to hypothetical protein YER175c -Saccharomyces cerevisiae
An10g00680	Catalytic activity: ATP+H(2)O<=>ADP+phosphate.; Function: the S. cerevisiae Cup5 protein is a proton-conducting pore forming subunit of the membrane integral V0 complex of the vacuolar ATPase. The v-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mV,inside positive and acidic, in the vacuolar membrane vesicles.; Remark: alternative names for the S. cerevisiae CUP5 gene: VMA3,CLS7,GEF2 or YEL027W.; Title: strong similarity to H+-ATPase V0 domain 17 KD subunit Cup5 - Saccharomyces cerevisiae; See PMID 8246899; See PMID 1825730
An10g00690	Remark: the S. cerevisiae gene product Tna1(=YGR260w) belongs to the Dal5 transporter family.; Similarity: the ORF shows similarity to several putative allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An10g00700	Induction: the expression of the S. cerevisiae ATR1 gene is induced by the famous yeast transcriptional regulators Gcn4 and Yap1.; Remark: S. cervisiae Atr1=YML116W.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9287330; See PMID 3280970
An10g00710	Title: strong similarity to hypothetical protein B3E4.80 - Neurospora crassa
An10g00730	Catalytic activity: A nitrile + H(2)O <=> a carboxylate + NH(3); Remark: the aliphatic nitrilase from Rhodococcus rhodochrous K22 protein ID: BAA02127. 1.; Title: strong similarity to aliphatic nitrilase -Rhodococcus rhodochrous; See PMID 1390687
An10g00740	Similarity: the ORF encoding DNA sequence shows significant similarity to retrotransposons or retroviruses.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8389699; See PMID 8522181; See PMID 8624443
An10g00780	Function: catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An10g00790	Title: similarity to hypothetical protein SCE6.29 -Streptomyces coelicolor
An10g00800	Function: the NUP nucleoside transporter from C. albicans is able to transport adenosine and guanosine, but not uridine, cytidine, adenine, guanine or uracil.; Title: strong similarity to purine nucleoside permease NUP - Candida albicans; See PMID 9802205
An10g00820	Catalytic activity: 1-carboxyvinyl carboxyphosphonat <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO(2).; Function: the BcpA gene product from Streptomyces hygroscopicuscatalyzes the formation of an unusual C-P bond and is involved in the biosynthesis of the antibiotic Bialaphos (ba).; Similarity: the BcpA gene product from Streptomyces hygroscopicus belongs to the Isocitrate-Lyase family.; Title: strong similarity to carboxyphosphonoenolpyruvate phosphonomutase bcpA -Streptomyces hygroscopicus; See PMID 1330557
An10g00830	Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein SC7H1. 16 from Streptomyces coelicolor.; Title: strong similarity to hypothetical protein EAA60090.1 - Aspergillus nidulans
An10g00840	Title: weak similarity to hypothetical adenylate/guanylate cyclase cyaF3 - Sinorhizobium meliloti
An10g00850	Title: strong similarity to indole-3-acetaldehyde dehydrogenase Iad1 - Ustilago maydis; See PMID 9022693
An10g00860	Catalytic activity: Gibberellin 20 + 2-oxoglutarate + O(2) <=> gibberellin 1 + succinate + CO(2).; Cofactor: the giberellin 3beta-dioxygenase from P. sativum needs Iron and Ascorbate.; Similarity: the ORF encoded protein shows also similarity to patent W04560.; Title: similarity to giberellin 3beta-dioxygenase Ps074 - Pisum sativum; See PMID 8904804
An10g00870	Function: the A. niger plyA gene encodes pectate lyase A.; Gene-ID: plyA; Remark: plyA exists in an unmodified and in an N-glycosylated form with identical specific activities.; Remark: the matching sequence of plyA from A. niger was found by a BLAST search against the new EMBL entry CAC33162.; Similarity: the ORF encoded protein shows also strong similarity to Bacillus licheniformis Pectate lyase II from patent WO9927083-A1.; See PMID 11112543
An10g00880	Function: the human monocarboxylate transporter 2 (hMCT2) catalyzes the H+/lactate-cotransport and facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates. It participates in the CORI cycle by exporting lactate from the intestine and the erythrocytes.; Remark: the ORF encoded protein is n-terminal extended in comparison to its homologues.; Similarity: the ORF encoded protein shows also similarity to the human patent WO9941373-A2.; Title: similarity to monocarboxylate transporter 2 hMCT2 - Homo sapiens; See PMID 9786900
An10g00890	Title: strong similarity to ankyrin Ank3 - Mus musculus; See PMID 7615634
An10g00900	Function: the protein (patent WO9710341-A1) from Fusarium oxysporum shows a natural D-pantolactone hydrolase activity.; Similarity: the published lactonase from Fusarium oxysporum (PubMed 1396712) is identical to the protein from patent WO9710341-A1.; Title: strong similarity to D-pantolactone hydrolase from patent WO9710341-A1 - Fusarium oxysporum; See PMID 1396712
An10g00910	Catalytic activity: digallate + H(2)O <=> 2 gallate.; Similarity: the tannase from Aspergillus oryzae (PubMed 9146733 and 8917102) is identical to patent JP08080196-A.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 9146733
An10g00920	Title: weak similarity to hypothetical protein encoded by An12g10350 - Aspergillus niger
An10g00930	Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An10g00940	Remark: the ORF has an unusual exon/intron structure for A. niger.
An10g00950	Catalytic activity: digallate + H2O = 2 gallate.; Function: the acylhydrolase tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Remark: tannase of A. oryzae can be used as a processing aid for the manufacture of cold water-soluble tea beverages and for clarification in beer production.; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Title: strong similarity to tannase precursor from patent JP08080196-A - Aspergillus oryzae; See PMID 8917102; See PMID 9146733
An10g00960	Function: inversin of M. musculus is responsible for left-right body axis determination.; Phenotype: the transgenic inv mouse (recessive deletion of the inversin gene) displays situs inversus and jaundice ('yellowing' by bilirubin, e. g. due to a liver problem).; Similarity: the ORF is much shorter than inversin of M. musculus (795 compared to 1062 amino acids).; Similarity: the ORF shows local similarity to inversin of M. musculus along a N-terminal stretch of about 200 amino acids.; Title: weak similarity to left-right axis pathway protein inversin invs - Mus musculus; See PMID 9771707; See PMID 10421642
An10g00970	Remark: the DNA sequence of the ORF shows similarity to a part of the A. oryzae EST from patent WO200056762-A2.; Title: strong similarity to hypothetical protein encoded by An03g01670 - Aspergillus niger
An10g00980	Remark: the ORF has an unusual exon/intron structure for A. niger.
An10g01000	Function: cpo of L. fumago catalyzes the peroxidative chlorination of organic acceptor molecules: 2 RH + 2 Cl- + H2O2 = 2 RCl + 2 H2O.; Induction: fructose induces mRNA and protein production of cpo of L. fumago, whereas glucose represses mRNA and protein production.; Remark: Leptoxyphium fumago is also called Caldariomyces fumago.; Title: similarity to chloride peroxidase cpo -Leptoxyphium fumago; See PMID 11278701; See PMID 3771564
An10g01010	Catalytic activity: cp100 of S. tuberosum catalyzes the reversible oxidation of vestitone to 2'-hydroxyformononetin.; Induction: expression of cp100 in the pistils of S. tuberosum is enhanced after pollination.; Remark: cp100 of S. tuberosum belongs to the 2'-hydroxyisoflavone reductase superfamily.; Similarity: about 75 C-terminal amino acids are not encompassed by the alignment between the ORF and S. tuberosum.; Title: similarity to 2-hydroxyisoflavone reductase cp100 - Solanum tuberosum; See PMID 9106515
An10g01020	Function: amyR of A. nidulans encodes a transcriptional activator for the amylase genes.; Phenotype: disruption of amyR of A. nidulans caused defects in the utilization of maltose and starch.; Remark: amyR of A. nidulans belongs to the GAL4 family of transcription factors.; Repression: expression of amyR of A. nidulans is regulated by the carbon catabolite repressor CREA.; Similarity: the ORF shows local (N-terminal) similarity to amyR of A. nidulans.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; nucleus; See PMID 11318101
An10g01030	Function: HGT1 of K. lactis is a high-affinity glucose transporter.; Phenotype: disruption of HGT1 of K. lactis leads to reduced glucose uptake and reduced growth in low-glucose medium.; Remark: HGT1 of K. lactis belongs to the sugar transporter family.; Similarity: the ORF is shorter than HGT1 of K. lactis (154 compared to 551 amino acids).; Similarity: the ORF shows only local similarity (over a stretch of ca. 100 amino acids) to HGT1 of K. lactis.; Title: similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679
An10g01040	Title: strong similarity to hypothetical IgE-binding protein - Aspergillus fumigatus
An10g01070	Remark: N-terminal truncated ORF due to end of contig.
An16g00010	Function: the patented alcohol dehydrogenase has at least one of the following enzymatic activities: (a) acetaldehyde dehydrogenase (ACDH) activity whereby acetyl CoA is converted into acetaldehyde; (b) alcohol dehydrogenase (ADH) activity whereby acetaldehyde is converted into ethanol; (c) the capability to convert acetyl CoA into ethanol; and (d) pyruvate formate-lyase (pfl) deactivase activity.; Remark: lactic acid bacteria containing the DNA sequence can be used for producing food products or animal feed, which have increased amounts of metabolites such as acetaldehyde, ethanol, formate, acetate, alpha-acetolactate, acetoin, diacetyl or 2,3 butylene glycol. the food products have improved flavour or improved shelf life due to the enhanced production of antimicrobially active metabolites.; Similarity: the predicted A. niger protein shows similarity to alcohol dehydrogenase of patent WO9807867-A2 from L. lactis (AC# AAW53944).; Title: similarity to alcohol dehydrogenase orfB from patent WO9807867-A2 - Lactococcus lactis
An16g00020	Function: Agt1p of S. cerevisiae is a high-affinity,maltose/proton symporter capable of transporting maltose,turanose, isomaltose, alpha-methylglucoside, maltotriose,palatinose, trehalose and melezitose.; Induction: AGT1 expression is maltose inducible and induction is mediated by the Mal-activator.; Similarity: the predicted A. niger protein shows strong similarity to the alpha-glucoside transport protein (AGT1) of S. cerevisiae which belongs to the maltose transport protein family.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329
An16g00030	Catalytic activity: cholinesterase 2 (ChE2) from B. floridae hydrolyses an acylcholine + H(2)O <=> choline + a carboxylic acid anion.; Inhibition: cholinesterase 2 (ChE2) from B. floridae is inhibited by BW284c51.; Localization: in vivo, the vast majority of ChE2 is localized in membranes as ethanolamine-glycan-phosphatidylinositol-anchored G2 forms.; Similarity: the predicted A. niger protein shows strong similarity to cholinesterase 2 (ChE2) from B. floridae and to other hydrolases which act on ester bonds.; Title: strong similarity to cholinesterase 2 ChE2 -Branchiostoma floridae; plasma membrane; See PMID 9874207
An16g00040	Remark: the CZF1 gene, encoding a putative transcription factor, was shown to be involved in the regulation of hyphal growth under certain conditions,including embedded conditions. ectopic expression of CZF1 in embedded cells promoted the rapid formation of hyphae. elimination of CZF1 and CPH1, encoding a homologue of the S. cerevisiae Ste12p transcription factor, led to a pronounced defect in filamentous growth of embedded cells.; Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to zinc-finger protein CZF1 -Candida albicans; See PMID 10564506; See PMID 1409649
An16g00050	Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to sequence 253 from patent WO0100804-A/253 of C. glutamicum (AC# AX066349) and to many putative multidrug-efflux transporters.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum
An16g00060	Remark: MesA of P. multocida confers a hemolytic phenotype in E. coli under anaerobic conditions.; Similarity: the predicted A. niger protein shows similarity to esterase MesA of P. multocida; Title: similarity to esterase mesA - Pasteurella multocida; See PMID 11064203
An16g00070	Similarity: the nucleotide sequence of the ORF shows strong similarity to the EST an_2627 of A. niger (AC# BE759725).; Title: strong similarity to EST an_2627 -Aspergillus niger
An16g00090	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An16g00110	Catalytic activity: EC 4. 1. 2. 13 catalyses the reversible cleavage of fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.; Complex: fructose-1,6-bisphosphate aldolase of T. aquaticus forms a homotetramer.; Pathway: EC 4. 1. 2. 13 is an enzyme of the glycolysis and gluconeogenesis pathways.; Title: strong similarity to fructose-1,6-bisphosphate aldolase - Thermus aquaticus; cytoplasm; See PMID 8898912; See PMID 11173490; See PMID 11237691
An16g00120	Catalytic activity: (S)-malate + NAD+ = oxaloacetate + NADH.; Pathway: citrate cycle (TCA cycle); pyruvate metabolism; glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: the MDH enzyme from Methanothermus fervidus is a homomeric dimer with a molecular mass of 70 kDa,possesses low specificity for NAD+ or NADP+ and catalyzes preferentially the reduction of oxalacetate.; Similarity: belongs to the malate dehydrogenase ylbC family.; Title: strong similarity to L-malate dehydrogenase MDH - Methanothermus fervidus; See PMID 2110059
An16g00130	Remark: hpaA gene forms a transcriptional unit with the hpaX transport gene.; Remark: hpaX in E. coli is a transport gene for an aromatic compound (4-hydroxyphenylacetate) of enteric bacteria.; Title: strong similarity to 4-hydroxyphenylacetate permease hpaX - Escherichia coli; See PMID 9126350; See PMID 9315705
An16g00140	Catalytic activity: cephalosporin C + H2O = deacetylcephalosporin C + acetate.; Remark: acyI Pseudomonas sp. converts cephalosporin C and 7 beta-(4-carboxybutanamido)cephalosporanic acid (GL-7ACA) to 7-aminocephalosporanic acid (7ACA).; Title: similarity to cephalosporin acylase acyI -Pseudomonas sp.; See PMID 2824449; See PMID 1358202
An16g00150	Remark: the uaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: belongs to the unassigned GAL4-type zinc cluster protein family.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421
An16g00160	Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate.; Pathway: Protocatechuate 4,5-cleavage pathway/phenylalanine metabolism.; Remark: LigI activity was inhibited by the addition of thiol reagents, suggesting that the cysteine residue is a catalytic site. LigI is more resistant to metal ion inhibition than the PDC hydrolases of Pseudomonas ochraceae.; Title: strong similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312
An16g00170	Function: D-alanine:D-alanine ligases are involved in the resistance to the antibiotic vancomycin, by catalysing the ester bound formation in the depsipeptide.; Title: weak similarity to D-alanine:D-alanine ligase-related protein DdlM - Streptomyces toyocaensis; See PMID 9177243
An16g00180	Catalytic activity: dTDPglucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O.; Pathway: nucleotide sugars metabolism; erythromycin biosynthesis.; Remark: also strong similarity to Salmonella enterica O antigen TDP-rhamnose pathway protein patent WO9850531-A1.; Remark: conserved genes like rmlB at the end of an O antigen gene cluster play a major role in mediating exchange of the central serogroup-specific regions in Salmonella enterica.; Similarity: belongs to the NAD dependent epimerase/dehydratase family.; Title: strong similarity to dTDP-D-glucose-4,6-dehydratase rmlB - Salmonella enterica; See PMID 10974117
An16g00200	Catalytic activity: trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.; Remark: dimeric dihydrodiol dehydrogenases (DDs, EC 1. 3. 1. 20), which oxidize trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols, have been molecularly cloned from human intestine, monkey kidney, pig liver, dog liver, and rabbit lens.; Similarity: belongs to the dehydrogenase and related protein family.; Title: strong similarity to dimeric dihydrodiol dehydrogenase SUS2DD - Sus scrofa; See PMID 10477285; See PMID 11306093
An16g00210	Remark: wecE is one protein in E. coli which is responsible for synthesis of the enterobacterial common antigen (ECA), a glycolipid situated on the outer leaflet of the outer membrane of members of the family Enterobacteriaceae.; Title: strong similarity to hypothetical regulator wecE - Escherichia coli; See PMID 9811644
An16g00230	Function: channel protein for glycerol. has a role in both glycerol influx and efflux. plays a role in osmoregulation: under osmotic stree the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.; Remark: Fps1 is a regulated yeast glycerol facilitator controlling glycerol production and cytosolic concentration, and might have additional functions.; Remark: the Orf has C-terminal similarity to the aquaporin protein family.; Similarity: belongs to the Major Intrinsic Protein Family.; Title: strong similarity to suppressor protein Fps1 - Saccharomyces cerevisiae; See PMID 7729414; See PMID 9401039; See PMID 10096077
An16g00240	Remark: transport assays revealed that the mae1 gene from fission yeast encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 8750236
An16g00250	Function: required for transport of secretory proteins from the golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.; Remark: SEC14 is an essential gene for yeast vegetative growth and is required for export of yeast secretory proteins from the Golgi complex.; Similarity: belongs to the sec14 cytosolic factor family.; Title: strong similarity to cytosolic factor Sec14 -Saccharomyces cerevisiae; See PMID 2215682; See PMID 2466847; See PMID 9461221
An16g00260	Catalytic activity: EC: 2. 5. 1. 29: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = pyrophosphate + geranylgeranyl diphosphate.; Catalytic activity: EC: 4. 1. 99. 7: trans,trans-farnesyl diphosphate <=> aristolochene + diphosphate.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; RemarK: the rice pathogen, Gibberella fujikuroi,produces large amounts of gibberellins, a group of natural plant hormones, which induce the superelongation (bakanae) disease of rice. Gibberellins are diterpenoid compounds which are synthesized via the isoprenoid pathway.; Remark: N-terminal is a aristolochene synthase activity and C-terminal there is the geranylgeranyl diphosphate synthetase activity.; Remark: there are two different enzyme activities in this ORF, but we propose one ORF with differential splicing.; Title: similarity to geranylgeranyl diphosphate synthase GGSII - Gibberella fujikuroi; See PMID 8440737; See PMID 9230902; See PMID 9917370
An16g00290	Title: similarity to hypothetical protein CAD70538.1 - Neurospora crassa
An16g00300	Catalytic activity: S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol.; Remark: also strong similarity to corn (Zea mays) SMT enzyme WO9845457-A1.; Remark: the enzyme requires glutathione as cofactor.; Similarity: belongs to the SAM-dependent methyltransferase family.; Title: strong similarity to 24-sterol C-methyltransferase ESMT1 - Zea mays; See PMID 9290641
An16g00320	Remark: putative endoglucanase but due to the patent there are no more informations available.; Remark: strong similarity to Zea mays sequence 11 from patent WO0073470 found in TREMBL:AX053132_1.; Similarity: to dienelactone hydrolase and related enzymes.; Title: strong similarity to endoglucanase sequence 11 from patent WO0073470 - Zea mays
An16g00330	Title: weak similarity to C-terminal domain of heat shock protein groEL - Lactococcus lactis
An16g00350	Remark: strong similarity to N. crassa mtr gene product patent WO9521263-A1.; Remark: the gene product of the mtr locus of Neurospora crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794; See PMID 1838345
An16g00360	Remark: weak similarity to human FAST-1 protein patent WO200002910-A2.; Title: weak similarity to forkhead activin signal transducer FAST-1 from patent WO200002910-A2 - Homo sapiens
An16g00370	Title: weak similarity to pneumococcal surface protein A PspA - Streptococcus pneumoniae
An16g00380	Remark: the Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to thiamine-repressible protein thi1p - Schizosaccharomyces pombe; See PMID 8088540; See PMID 1551569
An16g00390	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism.; Remark: in this contig there is putative a second salicylate hydroxylase in ORF 25CK.; Remark: shows also strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An16g00400	Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: four structural genes encoding isozymes of the alcohol dehydrogenase (ADH) system in the yeast Kluyveromyces lactis.; Remark: strong similarity to Aspergillus sp. alcohol dehydrogenase #1 patent US5958784-A.; Similarity: belongs to the Zn-dependent alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase 3 ADH3 - Candida sphaerica; See PMID 2190430; See PMID 1872030
An16g00410	Remark: strong similarity to human oxidoreductase protein (HORP)-4 patent WO200000622-A2.; Title: strong similarity to human oxidoreductase protein HORP-4 from patent WO200000622-A2 - Homo sapiens
An16g00420	Remark: shows also strong similarity to unknown aldolases and adducins.; Remark: strong similarity to P. putida R-(-)-mandelate monooxygenase of patent JP10099078-A found in GENESEQPROT:W53916.; Title: strong similarity to R(-)mandelate monooxygenase from patent JP10099078-A - Pseudomonas putida
An16g00430	Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634
An16g00435	Remark: a splice site was detected upstream of the START codon.
An16g00440	Catalytic activity: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH.; Remark: also strong similarity to alfalfa isoflavone reductase from Medicago sativa cv. Apollo patent WO9615239-A2.; Remark: play a distinct role in plant antioxidant defense and are possibly involved in NAD(P)/NAD(P)H homeostasis.; Similarity: belongs to the 2'-hydroxyisoflavone reductases.; Title: strong similarity to 2-hydroxyisoflavone reductase IFRH - Arabidopsis thaliana; See PMID 7592828
An16g00450	Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate.; Pathway: phenylalanine metabolism.; Remark: LigI activity was inhibited by the addition of thiol reagents, suggesting that the cysteine residue is a catalytic site. LigI is more resistant to metal ion inhibition than the PDC hydrolases of Pseudomonas ochraceae.; Title: similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312
An16g00460	Remark: alternate names are A616; YKL217w.; Remark: disruption of JEN1 S. cerevisiae abolished the uptake of pyruvate and gained the resistance against fluoropyruvate. No other monocarboxylate permease is able to efficiently transport lactate in S. cerevisiae.; Title: strong similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; See PMID 10198029; See PMID 10879467
An16g00500	Remark: there is weak similarity to Membrane-bound protein PRO1006 Homo sapiens patent WO9963088-A2.; Title: similarity to hypothetical F10K1.17 -Arabidopsis thaliana
An16g00520	Remark: putative salicylate hydroxylase.; Remark: strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: useful for industrial production of 2,5-di:hydroxy:pyridine.; Title: strong similarity to 6-hydroxynicotinic acid mono-oxygenase from patent JP09121864-A - Pseudomonas fluorescens
An16g00530	Function: tatD proteins are not required in sec-independent protein export like other tat proteins, but tatD of E. coli exhibits magnesium-dependent DNase activity.; Remark: C-terminal truncated ORF due to end of contig.; Title: strong similarity to cytoplasmic protein tatD - Escherichia coli [truncated ORF]; See PMID 10747959
An16g00540	Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to large secreted protein -Streptomyces coelicolor [truncated ORF]
An16g00550	Catalytic activity: R-CN + H2O = R-COOH + NH3.; Remark: acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Similarity: belongs to the family of nitrilases.; Title: strong similarity to nitrilase - Rhodococcus rhodochrous; See PMID 1400390
An16g00570	Title: questionable ORF
An16g00600	Remark: saframycin Mx1 is a DNA-binding antibiotic and antitumour agent produced by Myxococcus xanthus.; Similarity: to nonribosomal peptide synthetases.; Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus; See PMID 8936303
An16g00630	Catalytic activity: 2 RH + 2 chloride + H(2)O(2) = 2 RCl + 2 H(2)O.; Function: CPO of L. fumago catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione), the enzyme also has potent catalase activity and in the absence of halide ion, acts as a peroxidase similar to plant peroxidases.; Remark: CPO of L. fumago was also produced as recombinant protein in A. niger.; Remark: Leptoxyphium fumago is also called Caldariomyces fumago.; Remark: the enzyme catalyzes the chlorination of a range of organic molecules, forming stable C-Cl bonds; the structure and enzymatic activity of the molecule were deeply characterized and studied due to the potential application e. g. in the synthesis of vicinal dihalides,which are important as industrial solvents, refrigerants,flame retardants, and fumigating agents.; Similarity: the C-terminal part of the predicted protein does not shows similarity to CPO of L. fumago, and the protein length is different; thus the function prediction must be considered hypothetical.; Title: similarity to chloride peroxidase precursor CPO - Leptoxyphium fumago; See PMID 3198598; See PMID 3771564; See PMID 3774552; See PMID 2828306; See PMID 2883934
An16g00640	Function: the similarity is too weak to assign a function to the predicted protein.; Remark: human CDKN2A is also known as p16.; Title: weak similarity to cyclin dependent kinase inhibitor CDKN2A - Homo sapiens; See PMID 8259215
An16g00650	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563
An16g00660	Similarity: whereas the patented protein is a linoleate isomerase, the predicted ORF shows a structural domain typical of oxidoreductases; some short alignments to oxidoreductases are also identified by database search.; Title: similarity to linoleate isomerase from patent WO200100846-A2 - Propionibacterium acnes
An16g00670	Title: similarity to hypothetical protein AAO51454.1 - Dictyostelium discoideum
An16g00680	Remark: RTM loci are always physically associated with SUC telomeric loci. The SUC-RTM sequences are located between X and Y' subtelomeric sequences at chromosome ends.; Remark: RTM1 in S. cerevisiae confers resistance to the toxicity of molasses.; Remark: The particular subtelomeric position might explain the SUC-RTM sequence amplification observed in the genome of yeasts used in industrial biomass or ethanol production with molasses as substrate.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593
An16g00700	Title: strong similarity to hypothetical iron-sulfur binding oxidoreductase - Streptomyces coelicolor
An16g00710	Function: RD20 of A. thaliana is involved in seed dehydration.; Induction: RD20 of A. thaliana is inducible by abscisic acid under hyperosmotic stress conditions such as drought or high salinity.; Title: strong similarity to calcium-binding protein RD20 - Arabidopsis thaliana; See PMID 10965948
An16g00720	Function: TNA1 of S. cerevisiae is necessary for nicotinic acid uptake.; Remark: the systematic gene name of TNA1 in S. cerevisiae is YGR260w.; Similarity: belongs to the family of allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An16g00730	Function: FEN2 of S. cerevisiae is involved in the concerted regulation between the different pathways of carbon/nitrogen catabolite repression and the biosynthesis of amino acids and ergosterol.; Function: Fen2p of S. cerevisiae facilitates the cotransport of H+ and pantothenate.; Phenotype: fen2 mutants of S. cerevisiae are resistant to the antifungal drug fenpropimorph and display a reduced rate of ergostyrol synthesis in media exerting both carbon and nitrogen catabolite repression.; Remark: the systematic gene name of FEN2 of S. cerevisiae is YCR028c.; Title: strong similarity to pantothenate transporter protein Fen2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8771708; See PMID 10373490
An16g00740	Similarity: also shows smilarity to nitrogen metabolic repression proteins (nmr) of various fungal species.; Similarity: shows strong homology to protein patent database entry GENESEQPROT:Y14147.; Similarity: the protein sequence of patent Y14147 is identical with the sequence of the human HSCARG gene product.; Title: strong similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens
An16g00750	Function: CHA4 of S. cerevisiae activates the transcription of CHA1 which encodes a Ser/Thr deaminase involved in the utilization of serine and threonine as nitrogen sources.; Similarity: contains a domain homologous to fungal Zn(2)-Cys(6) binuclear cluster in which all six Cys residues are conserved.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; See PMID 8889513
An16g00760	Remark: possible sequencing error destroying a splicing donor site at position 37991.; Similarity: the homology region does not include the SH3 domain of Sh3yl1 of M. musculus.; Title: similarity to differentially expressed protein Sh3yl1 - Mus musculus [putative sequencing error]; See PMID 10771491
An16g00770	Function: the cDNA corresponding to the protein of patent W14439 can be used to improve the fermentation ability of Acremonium chrysogenum.; Function: the protein of patent W14439 is involved in cyclosporin C biosynthesis.; Remark: a putative sequencing error results in an frameshift.; Similarity: also shows strong similarity to multidrug transporters of diverse fungal species.; Similarity: shows strong homology to protein patent database entry GENESEQPROT:W14439.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [putative frameshift]; putative frameshift
An16g00780	Function: TetA of A. tumefaciens C58 confers resistance to tetracyclin and some of it's derivatives.; Repression: TetA expression in A. tumefaciens C58 is repressed by the transcriptional regulator TetR.; Title: strong similarity to tetracyclin resistance protein tetA - Agrobacterium tumefaciens; plasma membrane; See PMID 9882678
An16g00800	Function: Flu1 of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Title: strong similarity to fluonazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An16g00810	Function: HGT1 of S. cerevisiae is described as a high-affinity glutathion transporter.; Function: OPT1 of S. cerevisiae is described as an oligopeptide transporter specific for tetra- and pentapeptides including the endogenous opioids leucine enkephalin (YGGFL) and methionine enkephalin (YGGFM).; Remark: the systematic name of OPT1/HGT1 of S. cerevisiae is YJL212c.; Title: strong similarity to oligopeptide transporter Opt1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10652283; See PMID 10788431
An16g00830	Title: similarity to hypothetical protein encoded by An14g02830 - Aspergillus niger
An16g00840	Title: similarity to hypothetical protein encoded by An18g01250 - Aspergillus niger
An16g00850	Title: strong similarity to hypothetical protein SPAC9E9.15 - Schizosaccharomyces pombe
An16g00860	Title: similarity to hypothetical protein aos20 -Aspergillus oryzae
An16g00890	Title: strong similarity to hypothetical protein PA2448 - Pseudomonas aeruginosa
An16g00900	Similarity: shows homology to hypothetical hydrolases from S. coelicolor and P. aeruginosa.; Title: weak similarity to sequence 259 from patent WO0100842 - Corynebacterium glutamicum
An16g00910	Remark: the patent does not provide further information about the function of the protein.; Similarity: encodes a hypothetical NADH-dependent flavin oxidoreductase of the Old Yellow Enzyme family.; Title: strong similarity to sequence 385 from patent WO0100842 - Corynebacterium glutamicum
An16g00920	Catalytic activity: PMP20 of C. boidinii displays glutathione peroxidase activity toward alkyl hydroperoxides and H2O2.; Function: PMP20 of C. boidinii acts as an antioxidant enzyme decomposing reactive oxygen species generated at the peroxisomal membrane surface, e. g. lipid hydroperoxides.; Induction: PMP20 of C. boidinii is specific to peroxisomes induced by methanol utilization.; Localization: PMP20 of C. boidinii is peripherally associated with the inner side of the peroxisomal membrane.; Similarity: belongs to the peroxiredoxin 2 family.; Title: strong similarity to peroxisomal membrane protein PMP20 - Candida boidinii; peroxisome; See PMID 11278957; See PMID 2258389; See PMID 2760051
An16g00930	Similarity: the hypothetical protein NonF of Streptomyces griseus is probably involved in nonactin biosynthesis.; Title: similarity to hypothetical protein of the nonactin biosynthesis cluster nonF - Streptomyces griseus
An16g00940	Function: Flu1 of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An16g00960	Function: severin of D. discoideum binds to the plus (or barbed) ends of actin monomers or filaments,preventing monomer exchange (end-blocking or capping).; Function: severin of D. discoideum can promote assembly of monomers into filaments (nucleation) as well as disassociation (severing) of filaments already formed.; Function: the actin capping, severing and nucleating activities of severin of D. discoideum are Ca2+ dependent.; Similarity: contains a region highly homologous to a conserved actin-binding sequence duplicated in villin and gelsolin.; Title: strong similarity to actin-modulating protein severin - Dictyostelium discoideum; See PMID 1847147; See PMID 2826459
An16g00970	Similarity: shows deliberate homology matches to glycine-rich domains of various proteins from diverse species.; Title: weak similarity to hypothetical protein FB19 - Homo sapiens
An16g00980	Function: the acr-2 gene of Neurospora crassa controls acriflavine sensitivity.; Remark: the predicted ACR-2 protein has a putative Zn(II)Cys6 binuclear domain near the amino-terminus.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704
An16g00990	Catalytic activity: vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH. in the reverse direction, a 2'-hydroxyisoflavone is reduced to an isoflavonone.; Complex: IRL of Z. mays exists as a monomer.; Induction: IRL of Z. mays is induced by sulfur starvation.; Title: similarity to 2-hydroxyisoflavone reductase IRL - Zea mays; cytoplasm; See PMID 8597660
An16g01000	Remark: the ophD gene from Burkholderia cepacia encodes a permease for phthalate transport.; Remark: uptake inhibition experiments show that 4-hydroxyphthalate, 4-chlorophthalate, 4-methylphthalate,and cinchomeronate compete for the phthalate permease.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; See PMID 9851995
An16g01010	Similarity: the ORF is similar to the hypothetical protein SPAC5H10. 01 of S. pombe and hypothetical proteins from several prokaryotic species.; Title: strong similarity to hypothetical protein SPAC5H10.01 - Schizosaccharomyces pombe [truncated ORF]
An16g01020	Similarity: the ORF is shorter than the hypothetical nuclear protein of S. pombe (615 compared to 743 amino acids). 176 N-terminal and 101 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Title: similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe; See PMID 10759889
An16g01030	Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O (by similarity); Similarity: belongs to the cytochrome P450 family; Title: strong similarity to phenylacetate hydroxylase pahA - Penicillium chrysogenum; See PMID 10329644
An16g01040	Title: strong similarity to hypothetical MFS multidrug efflux transporter - Schizosaccharomyces pombe
An16g01070	Function: nit-4 of N. crassa is a transcription factor activating gene expression of nitrate assimilatory genes nit-3 and nit-6, which encode nitrate reductase and nitrite reductase, respectively.; Remark: activation of nit-3 and nit-6 requires the synergisitc interaction of the global-acting nit-2 with the pathway-specific nit-4 transcription factors.; Similarity: protein with a putative binuclear zinc DNA-binding domain; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1531376
An16g01080	Title: strong similarity to hypothetical short chain dehydrogenase SPAC521.03 - Schizosaccharomyces pombe
An16g01090	Catalytic activity: An epoxide + H(2)O <=> a glycol.; Title: strong similarity to epoxide hydrolase -Rattus norvegicus; endosome; See PMID 3032949; See PMID 3755318
An16g01110	Title: similarity to hypothetical negative acting factor like protein CAB91400.2 - Neurospora crassa
An16g01120	Title: similarity to hypothetical membrane protein YPL277c - Saccharomyces cerevisiae
An16g01130	Title: strong similarity to hypothetical plasma membrane iron permease - Schizosaccharomyces pombe
An16g01150	Function: Fre1 and Fre2 from S. cerevisiae encode cell surface metalloreductases that are required for reduction and uptake of free ferric iron.; Function: Fre2 from S. cerevisiae is together with Fre1 responsible for the total membrane-associated ferric reductase activity of the cell.; Title: strong similarity to ferric reductase Fre2 -Saccharomyces cerevisiae; See PMID 8164662; See PMID 11120744
An16g01170	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: C-terminally truncated due to contig border.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea [truncated ORF]; plasma membrane; See PMID 10521529
An16g01190	Catalytic activity: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.; Function: N-acetylation by hepatic NAT1 is a major route in the metabolism and detoxification of numerous drugs and foreign chemicals.; Remark: NAT1 has a wide specificity for aromatic amines, including serotonin.; Title: strong similarity to arylamine N-acetyltransferase NAT1 - Homo sapiens; See PMID 2340091; See PMID 9168895
An16g01200	Function: CTR is the sole choline transporter in yeast.; Induction: CTR activity is inhibited by intracellular choline.; Similarity: CTR belongs to the amino acid permease family.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793
An16g01210	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An16g01220	Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An16g01230	Function: brlA has a direct role in the regulation of cell cycle genes.; Function: brlA is a primary regulator of development-specific gene expression during conidiation.; Title: similarity to developmental regulatory protein brlA - Aspergillus nidulans; nucleus; See PMID 10601021; See PMID 3293800
An16g01240	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886
An16g01250	Catalytic activity: 6-OMT catalyzes methylation of the 6-hydroxyl group of norcoclaurine.; Function: 6-OMT is involved in isoquinoline alkaloid biosynthesis in Coptis japonica.; Title: strong similarity to S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase 6-OMT - Coptis japonica; See PMID 10811648
An16g01260	Function: TPO1 is involved in the resistance of yeast to polyamine toxicity.; Function: the membrane protein TPO1 is a polyamine transport protein on the vacuolar membrane.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 11171066
An16g01270	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An16g01280	Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Function: nahG catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715
An16g01290	Title: strong similarity to hypothetical protein encoded by An02g05930 - Aspergillus niger
An16g01300	Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical protein encoded by DR2561 - Deinococcus radiodurans [truncated ORF]
An16g01310	Catalytic activity: ALS/AHASs catalyze the ThPP- and FAD-dependent biosynthesis of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, as well as of acetolactate from two molecules of pyruvate.; Catalytic activity: Some ALS/AHASs also catalyze the (non-physiological) oxidative decarboxylation of pyruvate,leading to peracetic acid.; Function: bacterial ALS/AHAS consist of catalytic subunits (around 60 kDa) and smaller regulatory subunits in an alpha2beta2 structure.; Function: most ALS/AHAS are under allosteric control by branched-chain amino acids.; Pathway: ALS/AHASs catalyze the first step in the biosynthesis of the branched-chain amino acids valine,isoleucine, and leucine.; Remark: 'acetolactate synthase' (ALS) is often used synonymiously to 'acetohydroxyacid synthase' (AHAS or AHS).; Similarity: highest similarity to acetolactate synthase, large chain (ilvB) of Pyrococcus abyssi (strain Orsay), but there is no reference.; Title: strong similarity to acetohydroxyacid synthase large subunit ilvB - Methanococcus maripaludis; cytoplasm; See PMID 8973202; See PMID 1087175; See PMID 9655946; See PMID 10430574
An16g01320	Function: Pth11p of M. grisea functions as an upstream effector of appressorium differentiation in response to host surface recognition but is not required for appressorium morphogenesis.; Function: Pth11p of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: Pth11p of M. grisea functions at the cell cortex, but is also found in the vacuolar membrane.; Localization: contains three probable transmembrane domains.; Repression: Pth11p of M. grisea is probably downregulated by shunting the surface receptor protein to the vacuole by endocytosis.; Similarity: N-terminal three quarters (aa 8-296) show similarity to the middle domain (aa 104-374) of M. grisea PTH11 (631 aa).; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An16g01330	Function: TNA1 of S. cerevisiae encodes the high affinity nicotinic acid permease.; Function: TNA1 of S. cerevisiae is necessary for nicotinic acid import into the cell.; Remark: the systematic genename of TNA1 in S. cerevisiae is YGR260w.; Similarity: shows also similarity to several probable allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An16g01340	Catalytic activity: biphenyl-2,3-diol 1,2-dioxygenases catalyze the extradiol (meta-) cleavage of the first ring of 2,3-dihydroxybiphenyl.; Catalytic activity: ring-cleaving dioxygenase activity requires a coordinated Fe(II)-ion as a cofactor.; Remark: PubMed ID's are given for selected papers on meta-cleaving dioxygenases; Similarity: shares a conserved extradiol ring-cleavage dioxygenase motiv with biphenyl-2,3-diol 1,2-dioxygenase III from Rhodococcus globerulus.; Similarity: weak similarity to N-terminal two thirds of biphenyl-2,3-diol 1,2-dioxygenase III from Rhodococcus globerulus.; Title: strong similarity to hypothetical biphenyl-2,3-diol 1,2-dioxygenase VCA0463 - Vibrio cholerae; See PMID 8126007; See PMID 9857017; See PMID 1444267; See PMID 2670937
An16g01350	Title: strong similarity to hypothetical protein CAA10129.1 - Cicer arietinum
An16g01370	Function: UPC2 of S. cerevisiae is involved in the control of sterol uptake.; Remark: UPC2 belongs to a fungal regulatory family containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Remark: UPC2 is synonymous to YDR213W.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 9696767
An16g01380	Function: idiA of Synechococcus is a protein involved in the process of providing photosystem II with manganese.; Function: inactivation of the idiA gene in Synechococcus results in a mutant which is unable to grow under iron- or manganese-limiting conditions.; Title: weak similarity to iron-deficiency-induced protein IdiA - Synechococcus sp.; See PMID 8828233
An16g01390	Function: amyR of A. oryzae is a transcriptional activator involved in starch/maltose-induced efficient expression of amylolytic genes.; Similarity: amyR of A. oryzae has a zinc binuclear cluster motif (Zn(II)2Cys6) and belongs to the GAL4 family of transcription factors.; Similarity: similarity is restricted to N-terminal part of the protein.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498
An16g01400	Function: CTF1alpha of H. haematococca positively acts in vivo by binding selectively to palindrome 2 of the cutinase gene promoter.; Similarity: CTF1alpha of H. haematococca is N-andC-terminally longer than this protein.; Title: similarity to cutinase transcription factor 1 CTF1-alpha - Hematonectria haematococca; See PMID 9139694
An16g01410	Function: facB of A. nidulans is a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain which is required for DNA binding.; Function: facB of A. nidulans is required for acetate induction of acetamidase and several acetate utilization enzymes.; Similarity: facB of A. nidulans is C-terminally 200 aa longer.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 9524126
An16g01420	Function: MRP2 of A. thaliana is a multispecific ABC transporter for the transport of both glutathione S-conjugates and chlorophyll catabolites.; Title: similarity to ATP binding cassette transporter AtMRP2 - Arabidopsis thaliana; See PMID 9490749; See PMID 11115509
An16g01430	Remark: similarity only to an internal part of beta transducin-like protein of P. anserina.; Title: weak similarity to hypothetical beta transducin-like protein - Podospora anserina
An16g01440	Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa; See PMID 9524204
An16g01450	Cofactor: FAD.; Function: Xl64phr of X. laevis repairs pyrimidine (6-4) pyrimidone photoproducts in the DNA which are caused by UV irradiation.; Remark: due to sequence similarity to the photolyase/blue-light photoreceptor family a function as photoreceptor can not be ruled out completely.; Remark: photolyases and blue light photoreceptors have similar sequences but different catalytic activities.; Similarity: Xl64phr belongs to the photolyase/blue-light photoreceptor family.; Title: strong similarity to 6-4 photolyase Xl64phr -Xenopus laevis; See PMID 9016626; See PMID 9810509; See PMID 10422537
An16g01460	Title: strong similarity to hypothetical protein encoded by An11g04970 - Aspergillus niger
An16g01470	Similarity: the ORF is arginine-rich and repetitive and both causes the high e-value. However, the ORF shows also some specific similarity to B7F21. 40 of N. crassa.; Title: similarity to hypothetical protein B7F21.40 -Neurospora crassa
An16g01480	Catalytic activity: Spermidine + [eIF-5A]-lysine <=> 1,3-diaminopropane + [eIF-5A]-deoxyhypusine; EC:1.1.1.249; Function:Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor by transferring an aminobutyl moiety from spermidine to the epsilon-amino group of a unique lysine residue.; Title: strong similarity to deoxyhypusine synthase -Neurospora crassa; See PMID 7592594; See PMID 8615810
An16g01490	Catalytic activity: Ubiquitin C-terminal thiolester + H2O = Ubiquitin + a Thiol; EC:3.1.2.15; Function: Protein acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.; Title: similarity to ubiquitin carboxyl-terminal hydrolase uch2p - Schizosaccharomyces pombe; See PMID 10872838
An16g01500	Remark: Nop2p is an essential nucleolar protein in S. cerevisiae that is required for pre-rRNA processing and 60S ribosome subunit assembly in yeast.; Title: strong similarity to nucleolar protein Nop2 -Saccharomyces cerevisiae; nucleus; See PMID 7806561; See PMID 8972218; See PMID 9854021
An16g01510	Title: similarity to hypothetical protein B13N20.140 - Neurospora crassa
An16g01520	Localization: Zinedin is mainly expressed in the central nervous system; Remark: Zinedin is characterized by four protein-protein interaction domains, a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding domain, and a WD repeat domain, suggesting that it is a signaling or a scaffold protein. Protein binds calmodulin in the presence of Ca(2+).; Title: similarity to protein zinedin ZIN - Homo sapiens; See PMID 10748158
An16g01530	Remark: product: human downs syndrome critical region-like; Title: similarity to hypothetical protein SPAC22A12.13 - Schizosaccharomyces pombe
An16g01540	Similarity: strong similarity to S. pombe hypothetical protein SPAC24H6. 13, similarity to YOL084w,YLL005c and A. thaliana hyp1; Title: strong similarity to hypothetical membrane protein YMR266w - Saccharomyces cerevisiae
An16g01550	Title: strong similarity to hypothetical protein B23I11.160 - Neurospora crassa
An16g01560	Remark: GCD10 is an essential protein required in vivo for the initiation of total protein synthesis in S. cerevisiae.; Remark: alternate name in S. cerevisiae = YNL062C.; Title: strong similarity to protein Gcd10 -Saccharomyces cerevisiae; cytoplasm; See PMID 7542616; See PMID 10779558
An16g01570	Complex: protein belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc, p20-arc and p16-arc.; Function: part of the ARP2/3 complex implicated in the control of actin polymerization in cells.; Similarity: strong similarity to other p21-arc subunits.; Title: strong similarity to Arp2/3 complex 21kDa subunit ARC21 - Homo sapiens; See PMID 9230079; See PMID 10648568; See PMID 10801131
An16g01580	Remark: the yeast Arxula adeninivorans replication factor C (RF-C) is a multi-polypeptide complex with five sub-units involved in chromosomal DNA replication.; Title: strong similarity to replication factor C subunit ARFC3 - Arxula adeninivorans; See PMID 10022943
An16g01590	Remark: TOXA of Cochliobolus carbonum encodes an HC-toxin (host-selective cyclic tetrapeptide) efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Similarity: highly similar to several members of the major facilitator superfamily that confer resistance to tetracycline, methylenomycin, and other antibiotics.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997
An16g01600	Function: probable uptake of sugars in the form of monosaccharides by the growing pollen tube.; Induction: Pmt1 of Petunia hybrida is activated after the first pollen mitosis, and high levels of mRNA accumulate in mature and germinating pollen; Title: similarity to monosaccharide transporter 1 pmt1 - Petunia hybrida; plasma membrane; See PMID 9733549
An16g01610	Catalytic activity: 4-Trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.; Cofactor: a reaction dependent on Fe2+,alpha-ketoglutarate, ascorbate and oxygen.; Function: gamma-butyrobetaine hydroxylase catalyses the last step in carnitine biosynthesis.; Title: weak similarity to gamma-butyrobetaine hydroxylase BBH - Rattus norvegicus; See PMID 10526231; See PMID 10709635
An16g01620	Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate.; Remark: in addition to their catalytic role,hexokinases are thought to be involved in triggering carbon catabolite repression in Aspergillus nidulans.; Remark: mutations in the A. nidulans xprF and xprG genes have been shown to result in elevated levels of extracellular protease in response to carbon limitation in A. nidulans.; Title: strong similarity to hexokinase-like protein xprF - Aspergillus nidulans; See PMID 8628232; See PMID 11102357
An16g01630	Function: probably involved in lovastatin production.; Remark: polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis.; Remark: the lovastatin biosynthesis cluster contains two type I polyketide synthase genes in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An16g01640	Function: GAL4 of the yeast encodes a positive regulator of the galactose-inducible genes in S. cerevisiae.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 6366516
An16g01650	Catalytic activity: scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH.; Pathway: involved in the biosynthesis of melanin in pathogenic fungi (together with scytalone dehydratase).; Remark: abr2 has homology to the laccase encoded by the yA gene of Aspergillus nidulans.; Similarity: arp2 has a high similarity to hydroxynaphthalene reductases found in the dihydroxynaphthalene (DHN)-melanin pathway of brown and black fungi.; Title: strong similarity to 1,3,6,8-tetrahydroxynaphthalene reductase arp2 - Aspergillus fumigatus; See PMID 10515939
An16g01660	Remark: fluconazole-resistant strains exhibit increased expression of multidrug resistance transporters,especially MDR1 in Candida dubliniensis.; Similarity: C. dubliniensis encodes multidrug transporters similar to those encoded by the C. albicans MDR1, CDR1, and CDR2 genes (CaMDR1, CaCDR1, and CaCDR2,respectively).; Title: strong similarity to multidrug resistance protein MDR1 - Candida dubliniensis; plasma membrane; See PMID 9661028; See PMID 9986880
An16g01670	Catalytic activity: dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Remark: the peptide chain of the farnesyl-pyrophosphate synthetase FPPS from Gibberella fujikuroi carries two activities.; Title: strong similarity to farnesyl-pyrophosphate synthase FPPS - Gibberella fujikuroi; See PMID 8753652
An16g01680	Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Complex: the gluthathione S-transferase III from Zea mays forms a homodimer.; Function: the gluthathione S-transferase III from Zea mays conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and is involved in the detoxification of certain herbicides.; Remark: the ORF encoded protein is C-terminal longer than all homologues, this could be caused by an incorrect stopcodon due to a putative sequencing error.; Title: strong similarity to gluthathione S-transferase III GST3 - Zea mays; See PMID 3277162; See PMID 3532034
An16g01690	Remark: XPCT is subject to X chromosome inactivation, being expressed only from the active X in human.; Title: similarity to X-linked PEST-containing monocarboxylate transporter XPCT - Homo sapiens; plasma membrane; See PMID 9425115
An16g01700	Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Remark: next ORF also shows similarities to L-iditol 2-dehydrogenases.; Similarity: the ORF encoded protein only shows strong similarity to the n-terminal part of L-iditol 2-dehydrogenases. The ORF encoded protein (159aa) is shorter than the known L-iditol 2-dehydrogenases (347aa S. pombe).; Title: similarity to L-iditol 2-dehydrogenase (sorbitol dehydrogenase) tms1p - Schizosaccharomyces pombe; See PMID 8223615
An16g01710	Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Function: also catalyzes the oxidation by NAD+ of sorbitol to fructose.; Remark: previous ORF also shows similarities to L-iditol 2-dehydrogenases.; Title: strong similarity to L-iditol 2-dehydrogenase (sorbitol dehydrogenase) SORD - Homo sapiens; See PMID 7782086; See PMID 8088829
An16g01720	Catalytic activity: an alcohol + NADP(+) <=> an aldehyde + NADPH.; Title: strong similarity to aldehyde reductase ALR1 - Sus scrofa; See PMID 7484379; See PMID 9329083
An16g01730	Catalytic activity: an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Remark: acid phosphatases have wide specificity,also calyses transphosphorylations.; Title: similarity to acid phosphatase precursor rPAP - Rattus norvegicus; See PMID 4563528
An16g01740	Title: strong similarity to hypothetical protein encoded by An14g02280 - Aspergillus niger
An16g01750	Catalytic activity: peptidylproline (omega=180) <=> peptidylproline (omega=0).; Function: peptidyl-prolyl cis-trans isomerases accelerate the folding of proteins.; Remark: cyclophilin isoform 4 from C. elegans is involved in cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: similarity to peptidyl-prolyl cis-trans isomerase 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762
An16g01760	Function: the S. pombe HSF transcription factor binds to heat shock promoter elements and activates transcription of heat shock genes.; Title: similarity to heat shock transcription factor HSF - Schizosaccharomyces pombe; nucleus; See PMID 8423799; See PMID 9675818; See PMID 1986225
An16g01770	Function: the NAD(P)H-dependent yylose reductase from Pachysolen tannophilus reduces xylose into xylitol.; Pathway: the NAD(P)H-dependent xylose reductase from Pachysolen tannophilus is involved in D-xylose degradation.; Title: similarity to NAD(P)H-dependent xylose reductase XYL1 - Pachysolen tannophilus; See PMID 8923742
An16g01780	Expression: this gene is expressed during appressorium formation by Colletotrichum gloeosporioides conidia.; Induction: the expression of CAP22 gene from Colletotrichum gloeosporioides is induced by the host (avocado fruit) surface wax.; Remark: appressorien are short specialized hyphas,which are used by fungi as holdfasts at the host surfaces.; Title: similarity to protein CAP22 - Colletotrichum gloeosporioides; See PMID 7770033
An16g01790	Remark: collagen-like protein which is a epithelial surface receptor in pathogen fungi.; Title: similarity to fibronectin-binding protein sfs - Streptococcus equi; See PMID 3326135
An16g01800	Title: strong similarity to hypothetical protein YBL051c - Saccharomyces cerevisiae
An16g01810	Function: the histone H2A variant encoded by the pht1 gene in S. pombe is important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis.; Title: strong similarity to histone H2A variant pht1p - Schizosaccharomyces pombe
An16g01820	Title: strong similarity to hypothetical inorganic phosphate transporter and regulator of Pho81p Pho88 -Saccharomyces cerevisiae; See PMID 8709965
An16g01830	Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) <=> 3-phospho-D-glyceroyl phosphate + NADH; Gene-ID: gpdA;gpd; Mapping: gpdA from A. niger is mapped to chromosome V; see list from DSM, EMBL X99652.; Remark: a splice site was detected upstream of the START codon.; Remark: also acts very slowly on D-glyceraldehyde and some other aldehydes. Thiols can replace phosphate.; Similarity: identical to glyceraldehyde-3-phosphate dehydrogenase of Aspergillus niger.
An16g01840	Function: Hda1p of S. cerevisiae is involved in telomeric silencing and transcriptional regulation.; Function: Hda1p of S. cerevisiae is subunit of the HDA complex involved in histone deacetylation.; Remark: the systematic gene name of S. cerevisiae HDA1 is YNL021w.; Title: strong similarity to histone deacetylase A Hda1 - Saccharomyces cerevisiae; nucleus; See PMID 10856249; See PMID 8663039; See PMID 8962081
An16g01850	Function: bys1 in B. dermatitidis is expressed at very high levels in the yeast phase but whose levels diminish rapidly when yeast cells are transferred to 25 degrees C to promote conversion to the mycelial phase.; Remark: synonymous name of Ajellomyces dermatitidis is Blastomyces dermatitidis.; Title: similarity to blastomyces yeast phase-specific protein 1 bys1 - Ajellomyces dermatitidis; See PMID 8188377
An16g01860	EC:3.4.99.-; Similarity: shows also strong similarity to human and rat insulin degrading enzyme, and to several other zinc proteases from different sources.; Title: strong similarity to protease involved in a-factor processing Ste23 - Saccharomyces cerevisiae
An16g01870	Complex: in human, three major polypeptides of 25,59, and 68 kD and a less abundant polypeptide of 72 kD have been shown to copurify with CF Im (CFIM) activity.; Function: cleavage factors (CFs) Im and IIm, both of which are required in order for cleavage and polyadenylation to occur, are involved in the first step of 3'- processing.; Function: modifications include the generation of a new 3'-end by endonucleolytic cleavage followed by polyadenylation of the upstream cleavage product.; Function: most eukaryotic mRNA primary transcripts are processed both internally and at their termini in the nucleus, before they are exported to the cytoplasm.; Title: strong similarity to mRNA cleavage factor I 25 kDa subunit CFIM25 - Homo sapiens; See PMID 9659921
An16g01880	Similarity: sequence is almost identical to sequence 1 from Patent WO9831790, where the protein is described having a phospholipase activity.; Title: strong similarity to lysophospholipase -Aspergillus foetidus
An16g01890	Title: strong similarity to hypothetical protein encoded by An14g02280 - Aspergillus niger
An16g01900	Title: similarity to hypothetical protein encoded by An04g06980 - Aspergillus niger
An16g01920	Function: gabA of A. nidulans is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Similarity: shows also similarity to several putative fungal amino acid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An16g01940	Similarity: shows similarity to several probable transporter proteins of different species.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae; See PMID 10869563
An16g01950	Function: disruption of the YLL057c of S. cerevisiae encoding this enzyme negatively affects the use of isethionate and taurine as sulfur sources by S. cerevisiae,providing strong evidence that YLL057c plays a role in sulfonate catabolism.; Function: purified recombinant protein of YLL057c of S. cerevisiae is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536
An16g01970	Similarity: the similarity of the ORF to the hypothetical protein SPBC1734. 10c of S. pombe is restricted to the inner part, reaching from amino acid 129 to 180.; Title: similarity to hypothetical protein SPBC1734.10c - Schizosaccharomyces pombe
An16g01980	Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa
An16g01990	Title: similarity to hypothetical protein B18D24.50 - Neurospora crassa
An16g02000	Catalytic activity: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.; Remark: gabA of A. nidulans has 19 introns, an unusually large number of introns for fungal genes.; Remark: gabA of A. nidulans is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An16g02010	Function: PEX1 and PEX6 of P. chrysogenum encode proteins of the AAA family of ATPases.; Function: PEX6 of P. chrysogenum is involved in peroxisome biogenesis.; Function: the peroxisome biogenesis factors Pex4p,Pex22p, Pex1p, and Pex6p of P. chrysogenum act in the terminal steps of peroxisomal matrix protein import.; Title: strong similarity to peroxin-6 PEX6 -Penicillium chrysogenum; peroxisome; See PMID 10968639; See PMID 11003648
An16g02020	Function: A. terreus dihydrogeodin oxidase (DHGO) is an enzyme catalyzing the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to (+)-geodin.; Function: the phenol oxidative coupling reaction is involved in the biosynthesis of a wide range of natural products such as alkaloids (e. g. morphine, lycorine),lignans, and other phenolic compounds (e. g. usunic acid,griseofulvin).; Remark: putative sequencing errors have caused wrong gene prediction and perhapes also some other problems with the sequence.; Similarity: shows significant homology with other multicopper blue proteins such as laccase and ascorbate oxidase.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus [putative sequencing error]
An16g02040	Function: H. jecorina ACEI protein is DNA-binding; contains a nuclear localization signal; is a activator; binds to cbh1 promoter involved in cellulase regulator.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to Cys2-His2 zinc finger transcription factor ACEI - Hypocrea jecorina; nucleus; See PMID 10681571
An16g02060	Title: similarity to hypothetical protein Pa5D0029 -Podospora anserina
An16g02070	Similarity: shows only partial similarity to human ANG2 protein.; Title: similarity to hypothetical protein ANG2 -Homo sapiens
An16g02080	Title: similarity to hypothetical protein SPAC26A3.03c - Schizosaccharomyces pombe
An16g02090	Function: Ski2p, Ski3p, and Ski8p of S. cerevisiae inhibit translation of poly(A)- mRNA.; Function: Ski3p of S. cerevisiae controls propagation of M dsRNA virus through regulation of M dsRNA synthesis.; Function: Ski3p of S. cerevisiae is essential for protection against viral propagation.; Function: Ski3p of S. cerevisiae is part of a system to protect cells from dsRNA viruses.; Function: Ski3p of S. cerevisiae represses copy number of M1 dsRNA which encodes killer toxin.; Function: Ski3p of S. cerevisiae works together with Ski8p, probably through interaction of TRP and beta-transducin(WD-40) motifs.; Similarity: TPR domain-containing protein.; Title: strong similarity to antiviral protein Ski3 -Saccharomyces cerevisiae; See PMID 9482746
An16g02100	Title: strong similarity to hypothetical protein YIR007w - Saccharomyces cerevisiae
An16g02110	Remark: the sequence contains two putative sequencing errors.; Remark: this ORF was recognized by blastx analysis of the intergenic region of preceding and next ORF.; Remark: unfortunately the match against A. thaliana APG5 protein cannot be found using blastp.; Title: weak similarity to arabinogalactan-protein AGP5 - Arabidopsis thaliana [putative sequencing error]; putative sequencing error
An16g02120	Function: Msn5p of S. cerevisiae belongs to a family of proteins with a conserved N-terminal sequence that acts as a RanGTP-binding domain.; Function: Msn5p of S. cerevisiae is involved in several different signal transduction pathways.; Function: Msn5p of S. cerevisiae is suppossed to be a import or export receptor that interacts with the small GTPase Ran involved in the transport through the nuclear envelope.; Function: Msn5p of S. cerevisiae participates in processes such as catabolite repression, calcium signaling,mating, and cell proliferation, as well as being involved in previously characterized phosphate utilization.; Title: strong similarity to nuclear transport receptor Msn5 - Saccharomyces cerevisiae; See PMID 10545454
An16g02130	Function: murine protein is involved in cell death in response to IFN/RA.; Localization: murine GRIM19 is localized in the nucleus.; Title: similarity to novel cell death-regulatory protein GRIM19 - Mus musculus; See PMID 10924506
An16g02140	Title: strong similarity to hypothetical protein SPAC6B12.09 - Schizosaccharomyces pombe
An16g02150	Title: strong similarity to hypothetical protein SPBC1685.14c - Schizosaccharomyces pombe
An16g02160	Similarity: the C-terminal end, beginning with amino acid 100 of the predicted ORF, shows similarities to proteins probably involved in oxidation protection of genes, e. g. L82 of D. melanogaster and oxr1 of H. sapiens.; Title: strong similarity to hypothetical protein YPL196w - Saccharomyces cerevisiae; See PMID 11237729
An16g02170	Function: hyl1 of A. niger hydrolyses 4-nitrostyrene epoxide and other epoxides.; Gene-ID: hyl1; Similarity: the predicted ORF overlaps with A. niger ESTs BE759060 and BE760406.; Similarity: the sequence of the A. niger clone could encode an unpublished allelic product.; See PMID 10548561; See PMID 10673439
An16g02180	Remark: the predicted ORF is probably a member of the short chain dehydrogenase/reductase (sdr) family.; Similarity: the predicted ORF shows similarities to some dehydrogenases of different species.; Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe
An16g02190	Catalytic activity: proline racemaces catalyse the reaction L-proline <=> D-proline.; Similarity: the predicted ORF shows strong similarity to the central part of proline racemase prdF from C. sticklandii reaching from amino acid 54 to 245 of the 299 amino acids long protein.; Title: strong similarity to proline racemase prdF -Clostridium sticklandii; See PMID 10085076; See PMID 3718964
An16g02200	Title: similarity to hypothetical protein YBR246w -Saccharomyces cerevisiae
An16g02210	Function: rpn12 of S. cerevisiae is a component of the 19S regulatory particle of the proteasome and is therefore involved in ubiquitin-dependent protein degradation.; Phenotype: the null mutant of rpn12 of S. cerevisiae is inviable and the nin1-1 mutant is a temperature-sensitive mutant that shows i) higher rates of recombination and chromosome and plasmid loss; ii) greater sensitivity to UV irradiation; iii) at restrictive temperature, arrest in G2 phase, failure to activate histone H1 kinase, and accumulation of polyubiquinated proteins.; Remark: rpn12 is also called nin1.; Similarity: the predicted ORF overlaps with A. niger EST BE759311.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn12 - Saccharomyces cerevisiae; See PMID 8143766; See PMID 9584156; See PMID 1563492
An16g02220	Similarity: the similarity of the predicted ORF to the putative 6-hydroxy-D-nicotine oxidase related protein 13E11. 250 of N. crassa is restricted to the C-terminal end of the N. crassa sequence, starting with amino acid 428.; Title: weak similarity to hypothetical 6-hydroxy-D-nicotine oxidase related protein 13E11.250 -Neurospora crassa
An16g02230	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the predicted ORF shows much stronger similarity to the hypothetical protein B24M22. 200 of N. crassa.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An16g02240	Catalytic activity: PT1 of P. taeda catalyzes the reduction of the benzylic ether bond of dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alcohol to produce,respectively, isodihydrodehydrodiconyferyl alcohol and tetrahydrodehydrodiconiferyl alcohol.; Function: these compounds, as many other phenylpropanoids, are crucial for plant defense mechanisms,especially against fungal infections.; Similarity: a weaker similarity exists to putative and described oxidoreductases.; Similarity: the predicted ORF shows strong similarity to several hypothetical proteins with no known function.; Title: similarity to phenylcoumaran benzylic ether reductase PT1 - Pinus taeda; See PMID 10066819
An16g02250	Catalytic activity: CLN2 of H. sapiens encodes the lysosomal tripeptidyl peptidase I, an enzyme that that cleaves tripeptides from the N-terminus of polypeptides,but has also an endopeptidase activity.; Phenotype: deficiency of CLN2 in humans causes classical late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal childhood neurodegenerative disease.; Similarity: CLN2 of H. sapiens and the predicted ORF show significant sequence similarity to prokaryotic pepstatin-insensitive acid proteases.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; lysosome; See PMID 9653647; See PMID 9989590; See PMID 10428067; See PMID 10679303
An16g02260	Title: weak similarity to hypothetical cDNA FLJ20093 fis - Homo sapiens
An16g02280	Similarity: although the predicted ORF shows similarity to many fungal transcription factors, it does not contain the typical Zn(2)-Cys(6) fungal-type binuclear cluster domain, responsible for DNA binding of these proteins.; Similarity: the predicted ORF contains, instead,three leucine zipper domains, typical of other gene regulatory proteins.; Title: similarity to cutinase transcription factor beta CTF1b - Fusarium solani; nucleus; See PMID 9139694
An16g02290	Complex: ECI1 of S. cerevisiae is a homohexamer.; Function: ECI1 of S. cerevisiae acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids, converting 3-hexenoyl-CoA to trans-2-hexenoyl-CoA.; Induction: ECI1 transcripts are elevated in S. cerevisiae cells grown on oleic acid medium, as the gene promoter contains an oleate response element that binds the transcription factors Pip2p and Oaf1pin.; Phenotype: S. cerevisiae ECI1 null mutants are viable, but unable to grow on media containing unsaturated fatty acids such as oleic acid.; Remark: ECI1 of S. cerevisiae is also known as EHD1 or YLR284c.; Remark: the membrane localization is only putative.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046
An16g02300	Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae
An16g02310	Similarity: the predicted ORF shows some local similarity to different fragments of reverse transcriptases, likely resulting from retrotransposition events.; Title: weak similarity to reverse transcriptase pol - Tricholoma sejunctum
An16g02320	Title: weak similarity to protein fragment SEQ ID NO:38570 from patent EP1033405-A2 - Arabidopsis thaliana
An16g02330	Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8987357; See PMID 11065353
An16g02340	Title: questionable ORF
An16g02350	Catalytic activity: trichothecene 3-O-acetyltransferase of Fusarium catalyzes O-acetylation of the trichothecene ring specifically at the C-3 position in an acetyl-CoA-dependent manner.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of T-2 toxin.; Function: trichothecene 3-O-acetyltransferase protects Fusarium from the produced toxin.; Remark: trichothecene sesquiterpenoid mycotoxins are potent protein synthesis inhibitors for eukaryotic organisms, and are produced by different fungal genera,including Fusarium.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 9430709; See PMID 9762900
An16g02360	Catalytic activity: PLR of S. pombe catalyzes the reaction pyridoxine + NADP+ = pyridoxal + NADPH.; Pathway: PLR of S. pombe is involved in the vitamin B6 metabolism.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489
An16g02370	Remark: a very similar sequence from S. spinosa has been patented under patentnumber WO9946387-A1.; Remark: putative sequencing error at position 29690 introducing a stop codon conflicting with several good BLASTP matches.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: strong similarity to sequence 37 from patent WO0116303 - Saccharopolyspora spinosa [putative sequencing error]; putative sequencing error; See PMID 7742302
An16g02380	Similarity: the N-terminal part of the predicted ORF contains some motifs commonly found in oxidoreductases.; Title: strong similarity to hypothetical trunk lateral cell specific gene HrTLC1 - Halocynthia roretzi
An16g02390	Title: similarity to hypothetical protein encoded by An08g08410 - Aspergillus niger
An16g02400	Remark: the predicted ORF shows strong similarity to ORF 2 in the cited reference.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994
An16g02420	Title: weak similarity to hypothetical CG7701 -Drosophila melanogaster
An16g02430	Function: cofactor C of H. sapiens is a tubulin-folding protein, involved in the final step of the beta tubulin folding pathway.; Title: similarity to tubulin-folding cofactor C -Homo sapiens; See PMID 8706133
An16g02440	Title: strong similarity to hypothetical mlr1518 -Mesorhizobium loti
An16g02450	Similarity: the N-terminal half of the predicted ORF is constituted by almost 50% of low complexity regions,with weak similarity to several different neurofilament proteins of mammals.; Similarity: the main feture of the predicted ORF is to show similarity to the A. thaliana F17F16. 3 in the C-terminal half.; Title: similarity to hypothetical protein F17F16.3 -Arabidopsis thaliana
An16g02460	Complex: the coatomer is an oligomeric complex that consist of at least the alpha, beta, beta', gamma, delta,epsilon and zeta subunits.; Function: coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-ER transport of dilysine-tagged proteins.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER,via the golgi up to the trans golgi network.; Localization: the coatomer is cytoplasmic or polymerized on the cytoplasmic side of the golgi, as well as on the vesicles/buds originating from it.; Remark: the predicted ORF is almost identical, both at the protein and the DNA level, to the putative A. nidulans coatomer alpha subunit sodVIC.; Similarity: the predicted ORF shows strong similarity to the coatomer alpha subunit, conserved from yeast to mammals.; Title: strong similarity to alpha subunit of the coatomer complex Ret1 - Saccharomyces cerevisiae; See PMID 7724544; See PMID 8001155; See PMID 10361037
An16g02470	Complex: Erv1 of S. cerevisiae is a homodimer.; Function: Erv1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in S. cerevisiae.; Similarity: A. niger EST EMBLEST:BE759295 comprises the last nucleotides of the coding region and a part of the putative 3'-UTR of the predicted gene.; Similarity: the C-terminal part of Erv1 of S. cerevisiae is conserved also in the mammalian homologues and is responsible for the catalytic activity (formation of disulfide bridges).; Similarity: the N-terminal part of Erv1 of S. cerevisiae displays a high degree of variability and significant differences even among closely related species,which may account for differences in subcellular localization.; Similarity: the N-terminal part of the predicted ORF shows only weak similarity to Erv1 of S. cerevisiae.; Title: strong similarity to FAD-linked sulfhydryl oxidase Erv1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8972573; See PMID 10384986; See PMID 1552903; See PMID 10899311
An16g02480	Title: weak similarity to HIRA-interacting protein 3 HIRIP3 - Homo sapiens; See PMID 9710638
An16g02490	Function: adaptins mediate the interaction of transmembrane receptors to clathrin in the formation of the clathrin-coated transport vesicles.; Function: beta-adaptin is required for the formation of vesicles both at the plasma membrane coated pits, and at the TGN membranes.; Remark: the similarity of the predicted ORF to adaptins is weaker in the C-terminal, but it is possible that some coding regions are missing from the gene model due to the vicinity of the contig border.; Similarity: the predicted ORF shows strong similarity to the beta-adaptin of Drosophila, but also yeast, plants and mammalian species.; Title: strong similarity to beta-adaptin BAD1 -Drosophila melanogaster; See PMID 8006084; See PMID 1969413; See PMID 7593184
An16g02500	Catalytic activity: trpB of A. nidulans catalyses the reaction L-serine + L-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.; Cofactor: trpB of A. nidulans requires pyridoxal phosphate (by similarity).; Pathway: trpB of A. nidulans catalyses the last (fifth) step in biosynthesis of tryptophan.; Regulation: directly upstream of the transcriptional start site, one well conserved potential binding site for the cross-pathway control transcriptional activator CPCA was found. the level of trpB transcript was shown to be regulated by cross-pathway control. a knockout mutant for trpB displays tryptophan auxotrophy, no trpB transcript is detectable, and development is perturbed to an extent that is dependent on the amount of tryptophan added to the medium.; Similarity: tryptophan synthase (trpB) of A. nidulans is similar to the trpA and trpB family of tryptophan synthases.; Title: strong similarity to tryptophan synthase trpB - Aspergillus nidulans; cytoplasm; See PMID 10905354
An16g02510	Catalytic activity: alcohol dehydrogenase C (ADHC) of M. smegmatis catalyses the reaction alcohol + NADP+ = aldehyde + NADPH.; Cofactor: ADHC of M. smegmatis needs zinc as a co-factor.; Function: the kinetic parameters of the purified ADHC of M. smegmatis showed that using NADPH as electron donor it has a strong preference for aliphatic and aromatic aldehyde substrates. this enzyme is more likely to act as an aldehyde reductase than as an alcohol dehydrogenase.; Title: strong similarity to alcohol dehydrogenase C ADHC - Mycobacterium smegmatis; cytoplasm; See PMID 11257547
An16g02520	Catalytic activity: threonine synthase (THR4) of S. cerevisiae catalyses the reaction o-phospho-L-homoserine + H(2)O =L-threonine + orthophosphate.; Cofactor: THR4 of S. cerevisiae needs pyridoxal phosphate as a co-factor.; Pathway: THR4 of S. cerevisiae catalyses the last step in threonine biosynthesis.; Title: strong similarity to threonine synthase Thr4 - Saccharomyces cerevisiae; See PMID 2204248
An16g02530	Remark: N-terminal truncated ORF due to end of contig.; Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.
An16g02540	Catalytic activity: Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Function: In breast-fed infants, digestion of milk triglycerides is catalyzed by a concerted action of gastric lipase, colipase-dependent pancreatic lipase, and bile salt-stimulated lipase (BSSL).; Remark: C terminal truncated orf.; Similarity: the N-terminal half of the H. sapiens homolog BSSL is highly conserved between species and shows striking homology to typical esterases, for example,acetylcholine esterase. In contrast, the C-terminal half is unique to BSSL, but all typical properties of BSSL regarding its activity reside in the N-terminal half.; Title: strong similarity to biologically functional bile salt stimulated lipase BSSL from patent WO9325669-A -Homo sapiens [truncated orf]
An16g02550	Function: the S. cerevisisae homolog Pri1p is the DNA primase small subunit (DNA polymerase alpha 48 kDa subunit). This highly conserved DNA polymerase alpha-primase complex is required for both the initiation and elongation steps of DNA replication.; Remark: Eukaryotic DNA primase initiates the synthesis of all new DNA strands by synthesizing short RNA oligomers on single-stranded DNA. Additionally, primase helps couple replication and repair and is critical for telomere maintenance and, therefore, chromosome stability.; Title: strong similarity to DNA primase Pri1 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift
An16g02560	Remark: classification of Xylella fastidiosa homolog XF1621 by sequence similarity.; Title: strong similarity to hypothetical beta-lactamase XF1621 - Xylella fastidiosa
An16g02570	Function: the A. nidulans homolog suAprgA1 was isolated as a regulator of penicillin biosynthesis.; Remark: an Aspergillus nidulans strain deleted in the homolog suAprgA1 gene produced about 60% of the amount of penicillin produced by a wild-type strain.; Title: strong similarity to gene involved in the regulation of penicillin biosynthesis suAprgA1 -Aspergillus nidulans
An16g02580	Title: strong similarity to hypothetical protein YOR252w - Saccharomyces cerevisiae
An16g02590	Catalytic activity: the S. pombe homolog ExoI is a 5'->3' double-stranded DNA exonuclease.; Induction: S. pombe ExoI is induced during meiotic prophase I.; Similarity: the Schizosaccharomyces pombe gene exo1 is a member of a family of related DNA repair genes,including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans.; Title: strong similarity to exodeoxyribonuclease I exo1p - Schizosaccharomyces pombe
An16g02595	putative sequencing error
An16g02610	Function: S. cerevisiae Flr1p is a multiple drug resistance (MDR) determinant.; Induction: expression of S. cerevisiae FLR1 is induced by addition of benomyl, dependent on the pleiotropic drug resistance (PDR) network and the transcriptional regulator Pdr3p.; Similarity: the S. cerevisiae homolog Flr1p is a a transporter of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae
An16g02640	Title: strong similarity to hypothetical protein MTH632 - Methanobacterium thermoautotrophicum
An16g02650	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3929 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to hypothetical protein SPBC4.02c - Schizosaccharomyces pombe
An16g02660	Title: similarity to hypothetical RING finger protein - Schizosaccharomyces pombe
An16g02670	Title: weak similarity to hypothetical protein SPAC6B12.11 - Schizosaccharomyces pombe
An16g02680	Title: strong similarity to hypothetical protein YBR151w - Saccharomyces cerevisiae
An16g02700	Similarity: the S. cerevisiae homolog YIL130w shows GAL4 zinc binuclear cluster homology.; Title: similarity to hypothetical membrane protein YIL130w - Saccharomyces cerevisiae
An16g02730	Catalytic activity: A. niger ABN-A has arabinan-degrading activity and has the ability to cleave (1-2), (1-3) or (1-5) alpha L-arabinosidic linkages and can cleave the 1-6 linkage between the terminal arabinofuranosyl unit and the intermediate glucosyl unit of monoterpenyl alpha-L-arabinofuranosyl glucosides.; Remark: the A. niger homolog ABN-A is a secreted protein.; Title: strong similarity to endo 1,5-alpha-arabinase abnA from patent EP506190-A - Aspergillus niger
An16g02740	Title: strong similarity to hypothetical protein encoded by An15g02580 - Aspergillus niger
An16g02750	Remark: similarity to Arabidopsis sp. prenyltransferase designated ATPT3 patent WO200063391-A2.; Title: similarity to prenyltransferase designated ATPT3 from patent WO200063391-A2 - Arabidopsis sp.
An16g02760	Title: strong similarity to hypothetical protein BH0842 - Bacillus halodurans
An16g02770	Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 50033 patent EP1033405-A2.; Similarity: belongs to the dimethylaniline monooxygenase (N-oxide-forming) family.; Title: strong similarity to protein fragment SEQ ID NO:50033 from patent EP1033405-A2 - Arabidopsis thaliana
An16g02810	Remark: there are nucleoporins with different length matching to this ORF.; Title: weak similarity to nucleoporin Rat7 -Saccharomyces cerevisiae; See PMID 7744966
An16g02820	Remark: Fusarium oxysporum fatty-acid hydroxylase CYP505 is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3, a fused protein of cytochrome P450 and its reductase.; Title: strong similarity to fatty acid omega-hydroxylase CYP505 - Fusarium oxysporum; See PMID 8830036; See PMID 10995755
An16g02850	Remark: alternative name is YGR189c.; Remark: the yeast deletion mutant did not show mating, sporulation or growth defects and overexpression causes high resistance to ketoconazole (35 microM) and intermediate resistance to benomyl (140 microM) and miconazole (2 microM).; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; See PMID 10757808
An16g02880	Catalytic activity: L-lysine = cadaverine + CO2.; Catalytic activity: also acts on 5-hydroxy-L-lysine.; Similarity: the predicted protein shows much stronger similarity to S. cerevisiae YJL055w, a hypothetical protein with unknown function.; Title: similarity to lysine decarboxylase ECORLD -Eikenella corrodens; See PMID 11312612
An16g02890	Catalytic activity: adenosine + H2O = inosine + NH3; Phenotype: adenosine deaminase deficiency in mammals is the cause of one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins.; Title: strong similarity to adenosine deaminase Aah1 - Saccharomyces cerevisiae; See PMID 6392474; See PMID 9335580; See PMID 1577682
An16g02900	Title: weak similarity to hypothetical protein CP0627 - Chlamydophila pneumoniae
An16g02910	Function: due to the short stretches of homology to these proteins, the absence of further functional domains in the predicted ORF, and the hypothetical function assignement to many BLASTP homologues, it is not possible to draw conclusions about the function of the protein.; Similarity: the predicted protein shows also some similarity to a little portion of sugar hydrolases, like alpha-mannosidases or xylanases.; Title: strong similarity to hypothetical protein CC0533 - Caulobacter crescentus
An16g02920	Similarity: the similarity to A. nidulans amyR and other transcription facotrs is due to the presence of an N-terminal fungal binuclear zinc cluster.; Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; See PMID 11318101
An16g02930	Catalytic activity: ERG3 of S. cerevisiae encodes C-5 sterol desaturase, which catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis.; Phenotype: Cells lacking ERG3 are viable, but cannot grow on non-fermentable carbon sources, and some erg3 null strains are cold sensitive;furthermore mutations in ERG3 alter sensitivity to a wide variety of drugs.; Similarity: C-5 sterol desaturases have been identified in numerous organisms; homologs from Candida albicans, Arabidopsis, Nicotiana tabacum, and human can complements the erg3 null phenotype in S. cerevisiae.; Title: strong similarity to C-5 sterol desaturase Erg3 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7766188; See PMID 8109167; See PMID 8180700; See PMID 331007; See PMID 1864507
An16g02940	Similarity: the predicted protein shows equally strong similarity to the muscle specific human transcript PTD001, with unknown function.; Title: strong similarity to protein fragment SEQ ID NO:69506 from patent EP1033405-A2 - Zea mays
An16g02950	Title: strong similarity to essential protein SEQ ID NO:7146 from patent WO200253728-A2 - Candida albicans
An16g02960	Catalytic activity: a prenyl-L-cysteine + H2O = a prenol + L-cysteine.; Catalytic activity: the isoprenoid product of prenylcysteine lyase is the C-1 aldehyde of the isoprenoid moiety; the enzyme requires molecular oxygen as a cosubstrate and utilizes a noncovalently bound flavin cofactor in an NAD(P)H-independent manner; a stoichiometric amount of hydrogen peroxide is produced during the reaction; these findings indicate that prenylcysteine lyase utilizes a novel oxidative mechanism to cleave thioether bonds and provide insight into the unique role this enzyme plays in the cellular metabolism of prenylcysteines.; Function: prenylcysteine lyase is a lysosomal enzyme that cleaves prenylcysteines to cysteine during the degradation of prenylated proteins.; Remark: EC number: 4. 4. 1. 18.; Title: strong similarity to prenylcysteine lyase PCL1 - Homo sapiens; lysosome; See PMID 9287348; See PMID 10585463; See PMID 11078725
An16g02970	Catalytic activity: 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine.; Catalytic activity: glycine hydroxymethyltransferase also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.; Pathway: the enzyme is involved in many metabolic pathways, comprising the anabolism and catabolism of many amino acids and the regulation of the C1 pool through folates.; Remark: Serine hydroxymethyltransferase is officially called Glycine hydroxymethyltransferase.; Similarity: the strongest similarity is to the N. crassa protein; its function was demonstrated only by indirect evidences.; Title: strong similarity to cytoplasmic serine hydroxymethyltransferase Shm2 - Saccharomyces cerevisiae; cytoplasm; See PMID 8132653; See PMID 8852837; See PMID 9398220; See PMID 9749667; See PMID 10641038
An16g02980	Title: weak similarity to transferrin binding protein B tbpB - Moraxella catarrhalis; See PMID 9712766
An16g02990	Catalytic activity: 2-phospho-D-glycerate = 3-phospho-D-glycerate; 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; Pathway: the enzyme is essential for glycolysis and gluconeogenesis.; Similarity: the predicted ORF is almost identical to phosphoglyceromutase of A. oryzae, whose enzymatic activity was not experimentally demonstrated.; Title: strong similarity to phosphoglycerate mutase pgm - Bacillus subtilis; See PMID 8021172
An16g03000	Complex: the Gim complex is constituted by GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 and promotes the formation of functional alpha- and gamma-tubulin.; Remark: YKE2 of S. cerevisiae si also called GIM1 or YLR200w.; Title: strong similarity to Gim complex component Yke2 - Saccharomyces cerevisiae; cytoplasm; See PMID 7828874; See PMID 9463374
An16g03010	Complex: nucleotide-free or ADP-bound form of VPS4 exists as a dimer, whereas in the ATP-locked state, VPS4 dimers assemble into a decameric complex.; Function: VPS4 ATPase catalyzes the release (uncoating) of an endosomal membrane-associated class E protein complex(es) required for normal morphology and sorting activity of the endosome.; Function: VPS4 of S. cerevisiae is involved in vacuolar sorting, in the internalization and delivery steps of endocytosis.; Remark: VPS4 of S. cerevisiae is also known as VPT10, VPL4, END13, COS8, DID6 or YPR173c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps4 - Saccharomyces cerevisiae; See PMID 3062374; See PMID 3536126; See PMID 3538017; See PMID 2676511; See PMID 3049619
An16g03020	Function: in particular it must be noted that the predicted protein does not contain any recognized ATP-binding nor actin-binding motives, rather three leucine zipper domains.; Similarity: the A. nidulans protein and the predicted A. niger protein are similar to a S. pombe protein, called PCP1 or SPAC6G9. 06C, claimed to be a spindle body component that binds calmodulin, but still unpublished.; Similarity: the C-terminal part of the predicted protein is almost identical to A. nidulans calmodulin-binding coil-coil protein; this is a protein database entry derived from an uncomplete mRNA sequence,unpublished and with an hypothetical function assignment.; Similarity: the similarity to myosin heavy chain of many molluscs is much weaker, and the function assignment must be considered hypothetical.; Title: similarity to myosin heavy chain - Pecten maximus; See PMID 11129432
An16g03030	Title: strong similarity to hypothetical suppressor of S. cerevisiae gcr2 - Homo sapiens
An16g03040	Phenotype: AMMECR1 is a human gene of unknown function included in the deleted region of the contiguous gene deletion syndrome AMME, located in Xq22. 3, that includes Alport syndrome (A), mental retardation (M),midface hypoplasia (M), and elliptocytosis (E).; Similarity: the predicted ORF is identical to A. niger EST EMBLEST:BE760000.; Title: strong similarity to hypothetical AMMECR1 -Homo sapiens; See PMID 10049589; See PMID 10828604
An16g03050	Function: Ca2+/calmodulin-dependent protein kinases (CaM-kinases) II, IV, and I play important roles as Ca2+ responsive multifunctional protein kinases in controlling a variety of cellular functions in response to an increase in intracellular Ca2+.; Phenotype: null mutation of cmkB in A. nidulans is lethal; perturbations of gene function cause, among other effects, abnormal sporulation.; Similarity: cmkB of A. nidulans is the homologue of mammalian CaM kinases (CaMKs) I/IV.; Title: strong similarity to calcium/calmodulin dependent protein kinase cmkB - Aspergillus nidulans; See PMID 9601605; See PMID 10366852; See PMID 10609316; See PMID 10988293; See PMID 11173518
An16g03060	Function: POL2 of S. cerevisiae is the catalytic subunit A of the DNA polymerase epsilon, essential for DNA replication and involved in DNA nucleotide excision repair,required for arrest in response to inhibition of DNA replication.; Similarity: the predicted protein is very similar to nimP, the DNA polymerase epsilon homolog of Emericella nidulans, still unpublished.; Title: strong similarity to DNA-directed DNA polymerase epsilon Pol2 - Saccharomyces cerevisiae; nucleus; See PMID 7667891; See PMID 10022887; See PMID 10072354; See PMID 10097122; See PMID 1291235
An16g03070	Remark: the systematic gene name of COX20 is YDR231c.; Title: weak similarity to mitochondrial protein involved in cytochrome oxidase maturation and assembly Cox20 - Saccharomyces cerevisiae
An16g03090	Complex: Nop56p of S. cerevisiae physically interacts with Nop1p in the C+D box snoRNP.; Function: Nop56p of S. cerevisiae is also involved in 27SB pre-rRNA processing.; Function: Nop56p of S. cerevisiae is required for 35S pre-rRNA processing at the A0, A1 and A2 cleavage sites.; Localization: Nop56p of S. cerevisiae is localized at the nucleolus.; Pathway: Nop56p of S. cerevisiae is involved in the pathway of 18S, 25S and 5,8S rRNA biosynthesis.; Remark: the systematic gene name of NOP56 of S. cerevisiae is YLR197w, an alternative name is SIK1.; Title: strong similarity to small nucleolar RNP component Nop56 - Saccharomyces cerevisiae; nucleus; See PMID 9372940; See PMID 10733567
An16g03100	Complex: the TCP-1-containing cytosolic chaperonin of M. musculus is a heterooligomer including at least the CCT alpha, beta, gamma, delta, epsilon, zeta and eta subunits.; Function: the TCP-1-containing cytosolic chaperonin of M. musculus assists the folding of proteins upon ATP hydrolysis.; Remark: CctZ of M. musculus is subject of the protein sequence patent WO9520654-A1 (PATENTPROT:AAR79582).; Title: strong similarity to TCP-1-containing cytosolic chaperonin zeta subunit CctZ - Mus musculus; cytoplasm; See PMID 7953530
An16g03110	Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone; Function: hMOF of H. sapiens has histone acetyltransferase activity directed toward histones H3, H2A and H4.; Function: hMOF of H. sapiens is involved in the regulation of chromatin structure thereby excerting control of gene expression levels.; Function: the Drosophila ortholog MOF of hMOF of H. sapiens is part of the compensasome involved in gene dosage compensation.; Similarity: belongs to the MYST family of histone acetyltransferases.; Title: strong similarity to histone acetyl transferase hMOF - Homo sapiens; See PMID 10786633; See PMID 11230534
An16g03120	Function: NSR1 of S. cerevisiae binds the nuclear localization sequence of the histone H2B.; Function: NSR1 of S. cerevisiae is involved in pre-rRNA processing.; Similarity: homology to NSR1 of S. cerevisiae is restricted to the RNA recognition motif.; Title: similarity to nucleolar protein Nsr1 -Saccharomyces cerevisiae; See PMID 7926838; See PMID 1706724
An16g03130	Catalytic activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).; Function: YCR024c of S. cerevisiae is a nuclear gene coding for a mitochondrial tRNA-synthetase.; Title: strong similarity to mitochondrial asparagine--tRNA ligase YCR024c - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9030748
An16g03140	Similarity: belongs to the family of acyltransferases usually involved in secondary metabolism activities (PF02458).; Title: similarity to hypothetical anthranilate N-hydroxycinnamoyl/benzoyltransferase At2g19070 -Arabidopsis thaliana
An16g03160	Title: questionable ORF
An16g03190	Function: pac2 overexpression in S. pombe represses the expression of ste11 which controls the onset of sexual development.; Title: strong similarity to cAMP-independent repressor of ste11 expression ac2p - Schizosaccharomyces pombe; See PMID 8536311
An16g03210	Title: weak similarity to hypothetical transcriptional regulator - Clostridium acetobutylicum
An16g03220	Remark: CAB11213. 1 is encoded by SPAC17H9. 04c from S. pombe.; Title: weak similarity to hypothetical RNA-binding zinc finger protein CAB11213.1 - Schizosaccharomyces pombe
An16g03240	Title: weak similarity to hypothetical membrane lipoprotein CAC13380.1 - Mycoplasma pulmonis
An16g03250	Title: questionable ORF
An16g03260	Title: weak similarity to Ras guanine nucleotide exchange factor son-of-sevenless sos1 - Mus musculus
An16g03280	Title: weak similarity to Deltex1 - Mus musculus
An16g03290	Function: Uga3 from S. cerevisiae is a transcriptional activator for GABA catabolic genes.; Remark: synonyms for Uga3 from S. cerevisiae are YDL170w.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 10713424; See PMID 2109179
An16g03300	Regulation: the transcription of Uga4 from S. cerevisiae is induced in the presence of GABA.; Remark: Uga4 from S. cerevisiae is an amino acid permease with high specificity for 4-aminobutyric acid (GABA).; Remark: a synonym for Uga4 from S. cerevisiae is YDL210w.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 8455553; See PMID 8828907; See PMID 9678893
An16g03310	Function: the tol protein from Neurospora crassa mediates growth inhibition and cell death induced by fusion of hyphae of opposite mating type during vegetative growth.; Remark: the coiled-coil domain and the leucine-rich repeat of the tol protein from Neurospora crassa are required for activity.; Title: similarity to mediator for mating-type associated vegetative incompatibility tol - Neurospora crassa; See PMID 8200515; See PMID 9927450
An16g03320	Complex: human Sec24a co-immunoprecipitate with human Sec23aa.; Complex: human Sec24a co-localizes with the human proteins Sec23 and Sec13.; Function: human Sec24a is probably involved in ER to Golgi transport.; Similarity: human Sec24a belongs to the Sec23/Sec24 protein family.; Title: strong similarity to transport protein Sec24A - Homo sapiens; intracellular transport vesicles; See PMID 10075675
An16g03330	Remark: the ORF shows also strong similarity to the Aspergillus niger EST seq id no:4367 of patent WO200056762-A2.; Title: weak similarity to endo-1,4-beta-xylanase CAA93120.1 - Ascochyta pisi
An16g03340	Complex: X. laevis CPSF forms a specific complex with RNAs that contain both a cytoplasmic polyadenylation element (CPE) and the polyadenylation element AAUAAA.; Function: immunodepletion of the 100-kDa subunit of X. laevis CPSF reduces CPE-specific polyadenylation in vitro.; Localization: CPSF from X. laevis is predominantly localized to the cytoplasm of oocytes.; Title: strong similarity to cleavage and polyadenylation specificity factor 100 kDa subunit CPSF -Xenopus laevis; cytoplasm; See PMID 10409759
An16g03350	Similarity: the similarities are based on repetetive structures.; Title: weak similarity to silk fibroin like protein SEPL4 from patent WO8803533-A - synthetic
An16g03360	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to cell wall hydroxyproline-rich glycoprotein HRGPnt3 - Nicotiana tabacum
An16g03370	Localization: Cwh43 from S. cerevisiae is localized at the plasma membrane, although localization to the internal structure of the cells could not be excluded, and it concentrates to the bud tip of small budded cells and to the neck of dividing cells.; Phenotype: cwh43-2 mutant from S. cerevisiae shows Calcofluor white hypersensitivity, a growth defect and increased release of beta-1,6-glucan and beta-glucosylated proteins into the growth medium at increased temperatures.; Remark: the synonym for Cwh43 from S. cerevisiae is YCR017c.; Title: strong similarity to sensor/transporter protein involved in maintenance of cell wall integrity Cwh43 - Saccharomyces cerevisiae; plasma membrane; See PMID 11427965
An16g03380	Title: similarity to diagnostic protein #23219 from patent WO200175067-A2 - Homo sapiens
An16g03390	Remark: about the patent EP1033405-A2 is no further information available.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on mRNA obtained from A. thaliana.; Title: similarity to protein fragment SEQ ID NO:29234 from patent EP1033405-A2 - Arabidopsis thaliana
An16g03400	Function: deletion of nab3 in S. cerevisiae results in a decrease in the amount of mature ACT1, CYH2, and TPI1 mRNAs, a concomitant accumulation of unspliced ACT1 pre-mRNA, and an increase in the ratio of unspliced CYH2 pre-mRNA to mRNA.; Function: the Nab3 protein from S. cerevisiae proteins may be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing.; Remark: startcodon is missing.; Remark: synonyms for Nab3 from S. cerevisiae are Hmd1 and YPL190c.; Title: strong similarity to nuclear polyadenylated RNA-binding protein Nab3 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 7962083; See PMID 10655211
An16g03410	Similarity: the ORF also shows similarity to the EST SEQ ID NO:5884 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to hypothetical protein YMR244c-a - Saccharomyces cerevisiae
An16g03420	Function: overexpression of SYS1 suppresses the ypt6 phenotype of temperature-sensitive growth and partial missorting of the vacuolar enzyme, carboxypeptidase Y.; Phenotype: sys1 deletion mutants of S. cerevisiae show slight growth defects.; Phenotype: ypt6 sys1 mutants show enhanced defects in vacuolar protein sorting and cell growth; Remark: the synonym for Sys1 from S. cerevisiae is YJL004c.; Title: similarity to multicopy suppressor Sys1 -Saccharomyces cerevisiae; See PMID 8923208
An16g03430	Remark: novR belongs to the novobiocin biosynthetic gene cluster of Streptomyces spheroides.; Remark: novobiocin belongs to the aminocoumarin antibiotics.; Remark: novobiocin inhibits bacterial DNA gyrase by interaction with the N-terminal 24-kDa subdomain.; Similarity: the ORF also shows strong similarity to the EST Dark Grown 1 (DG1) Sorghum bicolor.; Title: strong similarity to novobiocin biosynthetic gene novR - Streptomyces spheroides; See PMID 10770754
An16g03450	Similarity: the ORF also shows strong similarity to the EST an_2900 from Aspergillus niger.; Title: similarity to hypothetical protein YNL051w -Saccharomyces cerevisiae
An16g03460	Title: questionable ORF
An16g03470	Title: weak similarity to hypothetical protein encoded by 12F11.190 - Neurospora crassa
An16g03480	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to neurofilament protein NF-M2 - Xenopus laevis
An16g03490	Phenotype: overexpression of RGM1 gene greatly impairs cell growth.; Remark: a splice site was detected upstream of the START codon.; Remark: the synonym for Rgm1 from S. cerevisiae is YMR182c.; Title: similarity to transcription repressor Rgm1 -Saccharomyces cerevisiae; nucleus; See PMID 1923755
An16g03500	Title: weak similarity to slow myosin heavy chain myoHC-A4 - Notothenia coriiceps
An16g03510	Title: strong similarity to hypothetical protein CAD70874.1 - Neurospora crassa
An16g03520	Complex: heterodimer of MSH2 and MSH6.; Function: MSH2 of S. cerevisiae is involved in post-replicative DNA-mismatch repair. Msh2 of S. cerevisiae binds to mismatch-containing DNA.; Similarity: MSH2 of S. cerevisiae belongs to the DNA mismatch repair muts family.; Title: strong similarity to DNA mismatch repair protein Msh2 - Saccharomyces cerevisiae; nucleus; See PMID 9545323
An16g03530	Function: gpi1 is necessary for the synthesis of n-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in gpi-anchor biosynthesis.; Title: similarity to n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1p - Schizosaccharomyces pombe; See PMID 9046095
An16g03540	Complex: Rrp6 of S. cerevisiae is a component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: Rrp4, Rrp40, Rrp41/Ski6, Rrp42, Rrp43,Rrp44/Dis3, Rrp45, Rrp46, Mtr3, Csl4 and Rrp6.; Function: Rrp6 of S. cerevisiae is a component of the nuclear exosome 3->5 exoribonuclease complex. Rrp6 is required for the 3'processing of the 7s pre-rna to the mature 5. 8s rrna. Rrp6 has a 3'-5' exonuclease activity.; Remark: UNC733 and YOR001W are alternative names for RRP6.; Title: strong similarity to exosome complex exonuclease Rrp6 - Saccharomyces cerevisiae; nucleus; See PMID 9582370
An16g03550	Title: similarity to protein fragment SEQ ID NO:17361 from patent EP1033405-A2 - Arabidopsis thaliana
An16g03570	Title: weak similarity to hypothetical protein pr1 -Cytomegalovirus maastricht
An16g03580	Function: sar1 of S. pombe encodes a product capable of regulating ras1 function.; Similarity: sar1 of S. pombe is a member of the family of amily of RAS GTPase-activating proteins (GAPs).; Title: strong similarity to RAS GTPase-activating protein sar1p - Schizosaccharomyces pombe; See PMID 1883874; See PMID 2038319
An16g03590	Function: sec14 of S. cerevisiae is required for transport of secretory proteins from the golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.; Remark: SEC14 is an essential gene for yeast vegetative growth and is required for export of yeast secretory proteins from the Golgi complex.; Similarity: sec14 of S. cerevisiae belongs to the sec14 cytosolic factor family.; Title: strong similarity to phosphatidylinositol-phosphatidylcholine transfer protein Sec14 - Saccharomyces cerevisiae; cytoplasm; See PMID 9461221; See PMID 2215682; See PMID 2466847
An16g03600	Title: similarity to hypothetical protein SPAC688.02c - Schizosaccharomyces pombe
An16g03610	Title: similarity to hypothetical protein SPAC1296.04 - Schizosaccharomyces pombe
An16g03620	Title: similarity to hypothetical protein CAD37049.1 - Neurospora crassa
An16g03630	Function: MAK3 encodes an N-acetyltransferase whose modification of the L-A major coat protein NH2 terminus is essential for viral assembly, unassembled coat protein is unstable.; Title: strong similarity to N-acetyltransferase Mak3 - Saccharomyces cerevisiae; See PMID 1339437; See PMID 1400344
An16g03640	Catalytic activity: Phosphatidylcholin + a sterol <=> a sterol ester + 1-acylglycerophosphocholine.; Function: mouse LCAT catalyzes the esterification of cholesterol in high density lipoproteins.; Title: similarity to phosphatidylcholine-sterol O-acyltransferase Lcat - Mus musculus; See PMID 2600083
An16g03650	Function: aurA gene product is necessary for inositol phosphorylceramide (IPC) synthase activity.; Phenotype: mutations in aurA gene of A. nidulans confer a high level of resistance to aureobasidin A.; Title: strong similarity to aureobasidin-resistance protein aurA - Aspergillus nidulans; See PMID 10102364
An16g03660	Remark: the ORF shows similarity to cDNA of the aureobasidin-resistance protein aur1 of A. fumigatus. This cDNA belongs to the adjacent gene.; Title: questionable ORF
An16g03690	Function: involved in both homeostasis of calcium and manganese ions.; Localization: Ccc1p polypeptide was found to localize to a Golgi-like organelle in yeast.; Title: strong similarity to iron and manganese transporter Ccc1 - Saccharomyces cerevisiae; See PMID 7941738
An16g03700	Catalytic activity: Phospholipase B catalyzes the reaction of 2-Lysophosphatidylcholine + H2O = Glycerophosphocholine + a fatty acid anion.; Function: Phospholipase B is useful for hydrolysing the fatty acyl group(s) of phospholipids or lysophospholipids, such as lecithin or lysolecithin.; Remark: the ORF encoded protein also shows strong similarity to hypothetical phospholipases C (EC 3. 1. 4. 3) of A. thaliana.; Title: strong similarity to phospholipase B from patent US6146869-A - Aspergillus oryzae
An16g03710	Title: weak similarity to hypothetical protein CAD60720.1 - Podospora anserina
An16g03720	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886
An16g03740	Function: pkaR from A. niger is involved in morphogenesis.; Gene-ID: pkaR; Remark: a splice site was detected upstream of the START codon.; deleted EC_number 2.7.1.37
An16g03750	Remark: the coding sequence of the protein from patent EP1033405-A2 was isolated by carrying out RT-PCR on all of the mRNA obtained from the plant, and creating a cDNA library which could then be sequenced, allowing the putative protein sequence(s) to be obtained.; Title: similarity to protein fragment SEQ ID NO:72807 from patent EP1033405-A2 - Arabidopsis thaliana
An16g03760	Title: similarity to hypothetical protein 15E6.220 -Neurospora crassa
An16g03770	putative frameshift
An16g03790	Remark: the ORF encoded protein also shows similarity to a hypothetical cyclin-like protein of S. cerevisiae.; Title: similarity to hypothetical protein SPBC1D7.03c - Schizosaccharomyces pombe
An16g03800	Function: the protein from patent WO200008187-A2 is involved in environmental stress tolerance.; Title: similarity to environmental stress tolerance related protein from patent WO200008187-A2 - Arabidopsis thaliana
An16g03810	Title: similarity to hypothetical protein B7F18.100 - Neurospora crassa
An16g03820	Title: similarity to hypothetical protein B2J23.130 - Neurospora crassa
An16g03830	Function: pch1p of S. pombe interacts with the cdc2 protein kinase.; Function: pch1p of S. pombe is essential for progression through the whole cell cycle.; Similarity: pch1p of S. pombe belongs to the cyclin family, cyclin C subfamily.; Similarity: the predicted ORF is 188 amino acids shorter at its C-terminus than pch1 of S. pombe.; Title: similarity to cyclin C homolog 1 pch1p -Schizosaccharomyces pombe; See PMID 9115279
An16g03840	Function: ctf1-alpha of F. solani is a transactivator that binds to the palindrome 2 sequence of the cutinase gene promoter.; Remark: the ORF encoded protein shows weak similarity to several transcription factors and contains BLOCKS and PROSITE Zinc-finger motifs.; Title: weak similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; nucleus; See PMID 9139694
An16g03850	Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe
An16g03860	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: as the its human ortholog, the p70 ribosomal protein S6 kinase p70S6k from Artemia franciscana may be involved in the regulation of protein synthesis during preemergence development.; Title: strong similarity to p70 ribosomal protein S6 kinase p70S6k - Artemia franciscana; deleted EC_number 2.7.1.37; See PMID 11310561
An16g03870	Similarity: the similarities of the ORF encoded protein to all matching proteins are only based on repetitive structures.; Title: weak similarity to transcription termination factor Rho - Micrococcus luteus
An16g03880	Catalytic activity: 2-amino-4-hydroxy-6-(D-erythro-1, 2,3-trihydroxypropyl)-7,8-dihydropteridine <=> 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.; Function: the multifunctional folic acid synthesis protein Fas from Pneumocystis carinii Folate biosynthesis.; Title: similarity to multifunctional folic acid synthesis protein Fas - Pneumocystis carinii; See PMID 8397083
An16g03890	Function: human SRp75 can complement a splicing-deficient extract.; Similarity: the human SRp75 protein belongs to the SR family of splicing factors.; Title: similarity to pre-mRNA splicing factor SRp75 - Homo sapiens; nucleus; See PMID 1577277; See PMID 8321209
An16g03910	Catalytic activity: reduced ETF + ubiquinone <=> ETF + ubiquinol (ETF=Electron-transferring-flavoprotein).; Cofactor: Iron-sulfur, FAD.; Function: the human electron-transfer flavoprotein-ubiquinone oxidoreductase ETF-QO in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane.; Title: strong similarity to electron-transfer flavoprotein-ubiquinone oxidoreductase ETF-QO - Homo sapiens; localisation:mitochondrion; See PMID 10423253; See PMID 8306995
An16g03920	Title: weak similarity to negative regulator LIN-1 -Caenorhabditis elegans
An16g03930	Title: weak similarity to hypothetical uridylate kinase from chromosome III BAC T22K18 - Arabidopsis thaliana
An16g03940	Complex: together with the TAF proteins TBP belongs to the TFIID complex, which specifically binds to the TATA box element of PolII relevant promotors and which lies close to the position of transcription initiation.; Function: TBP is the general factor that plays a major role in the activation of eukaryotic genes transcribed by RNA Polymerase II.; Remark: TBP is also called SPT15, BTF1 or YER148.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to subunit of transcription initiation factor TFIID TATA-box binding protein TBP -Aspergillus nidulans; nucleus; See PMID 9141689; See PMID 10974559
An16g03950	Cofactor: FAD.; Function: amadoriases are a novel class of FAD enzymes which catalyze the oxidative deglycation of glycated amino acids to yield corresponding amino acids,glucosone, and H(2)O(2).; Remark: alternate name for amadoriase II A. fumigatus: fructosyl amine:oxygen oxidoreductase.; Title: strong similarity to amadoriase II -Aspergillus fumigatus; See PMID 9139700; See PMID 10684633
An16g03960	Title: similarity to hypothetical proteins YDR316w -Saccharomyces cerevisiae
An16g03980	Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to hypothetical protein CAF06114.1 - Neurospora crassa [truncated ORF]
An16g03990	Title: questionable ORF
An16g04000	Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: FacB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An16g04010	Complex: Tid3 from S. cerevisiae forms a centromere complex together with Nuf2, Spc25 and Spc24.; Remark: synonyms for yeast Tid3 are Ndc80, Hec1,Yil144w.; Title: strong similarity to protein involved in modulating chromosomal segregation Tid3 - Saccharomyces cerevisiae; See PMID 11266451; See PMID 11553715; See PMID 9585415
An16g04020	Function: Pex14 from Hansenula polymorpha is a peroxisomal membrane protein essential for peroxisome biogenesis.; Localization: Pex14 from Hansenula polymorpha is a component of the peroxisomal membrane.; Remark: Hansenula polymorpha = Pichia angusta.; Title: strong similarity to peroxisomal membrane protein Pex14 - Hansenula polymorpha; peroxisome; See PMID 11330059; See PMID 9009266
An16g04030	Title: similarity to hypothetical protein B15B10.090 - Neurospora crassa
An16g04040	Remark: the patent protein AAY81534 can be useful as a vaccine, for diagnosis of pneumococcal diseases and for screening agents capable of antagonizing or inhibiting expression of the protein.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_2908 from Aspergillus niger.; Similarity: weak similarity to patent protein AAY81534 from Streptococcus pneumoniae.; Title: weak similarity to membrane protein yeeO -Escherichia coli
An16g04050	Remark: a clone selected by a screen with rabbit anti-serum against N40 contains a bicistronic operon (AAQ83837) encoding OspE (AAR69628) and OspF (AAR69629) surface lipoproteins.; Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to surface lipoprotein from patent WO9504145-A1 - Borrelia burgdorferi
An16g04060	Remark: the protein BAB55393. 1 is encoded by the cDNA FLJ14917 fis, clone PLACE1007112 - Homo sapiens.; Title: similarity to hypothetical protein BAB55393.1 - Homo sapiens
An16g04070	Title: weak similarity to hypothetical protein BAB08329.1 - Arabidopsis thaliana
An16g04080	Function: the tubulin-tyrosine ligase from Sus scrofa catalyzes the ATP-dependent posttranslational addition of tyrosine to the carboxyterminal end of alpha-tubulin.; Title: similarity to tubulin-tyrosine ligase - Sus scrofa; See PMID 11004583; See PMID 8093886
An16g04090	Remark: Suggested activities include nutritional sources or supplements, immune stimulating or suppressing activity, haematopoiesis regulating activity, tissue growth activity, activin/inhibin activity,chemotactic/chemokinetic activity, haemostatic and thrombolytic activity, receptor/ligand activity,anti-inflammatory activity, cadherin/tumour invasion suppressor activity and tumour inhibition activity.; Remark: the protein is predicted to have biological activities although no supporting data is given.; Title: strong similarity to secreted protein from patent WO9855614-A2 - Homo sapiens
An16g04100	Complex: Cdc39 (Not1) forms a complex together with Not2, Not3, Not4 and Not5.; Function: Cdc39 is a global negative regulator of transcription.; Remark: synonyms for the S. cerevisiae Cdc39 protein are Not1, Ros1, Smd6 and YCR093w .; Title: strong similarity to transcription regulator protein Cdc39 - Saccharomyces cerevisiae; nucleus; See PMID 10661863; See PMID 8428577; See PMID 9463387
An16g04110	Function: the S. pombe cdc15 gene is involved in septum formation. it is a key element in the reorganization of F-actin at mitosis.; Phenotype: mutations in the S. pombe early septation mutant cdc15 lead to the formation of elongated,multinucleated cells, as a result of S phase and mitosis continuing in the absence of cytokinesis.; Title: strong similarity to cdc15p -Schizosaccharomyces pombe; See PMID 7634333
An16g04120	Title: similarity to hypothetical protein SPBC32F12.08c - Schizosaccharomyces pombe
An16g04130	Title: similarity to hypothetical protein B8I24.160 - Neurospora crassa
An16g04140	Phenotype: cdc23 mutants show reduced rates of DNA synthesis and become elongated after cell-cycle arrest.; Remark: the Schizosaccharomyces pombe Cdc23 is required for correct DNA replication.; Title: similarity to replication protein cdc23p -Schizosaccharomyces pombe; See PMID 9745018; See PMID 1934126
An16g04150	Title: strong similarity to hypothetical protein B8I24.140 - Neurospora crassa
An16g04160	Catalytic activity: ATP + D-galactose <=> ADP + D-galactose 1-phosphate.; Function: the GAL1 gene product converts D-galactose to D-galactose-1-phosphate.; Induction: S. cerevisiae Gal1 is able to relieve the Gal80p-dependent repression of the transcriptional activator of Gal4p.; Induction: the S. cerevisiae GAL1 transcription is controlled by the Gal4p-Gal80p complex. GAL1 induction is galactose dependent.; Title: strong similarity to galactokinase Gal1 -Saccharomyces cerevisiae; cytoplasm; See PMID 6374427; See PMID 9670023; See PMID 1922058
An16g04170	Catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate.; Cofactor: Thiamine pyrophosphate.; Function: acetolactate synthases catalyses the first step in the valine and isoleucine biosynthesis pathway.; Remark: mutant acetolactate synthase genes can be used for transforming plants to generate resistance to sulphonylurea, triazolopyrimidine sulphonamide and imidazolinone herbicides (see also patent US5605011-A).; Title: strong similarity to acetolactate synthase protein from patent EP257993-A - Saccharomyces cerevisiae; See PMID 2684671; See PMID 3881312
An16g04180	Title: similarity to hypothetical protein AAF45871.1 - Drosophila melanogaster
An16g04190	Similarity: the similaritiy of the protein to the matching protein is mainly based on repetitive structures.; Title: weak similarity to retinitis pigmentosa GTPase regulator protein AAG00552.1 - Mus musculus
An16g04200	Function: Rho2 GTPase regulates the synthesis of alpha-D-glucan; Function: the Schizosaccharomyces pombe GTPase rho2 is involved in the control of cell morphogenesis, cell integrity, and polarization of the actin cytoskeleton.; Similarity: the protein shows also strong similarities to other Rho-like Proteins like Candida CaRho1 protein (patents WO9946286-A2, WO9738293-A2,WO9738129-A1).; Title: strong similarity to GTP-binding protein rho2p - Schizosaccharomyces pombe; plasma membrane; See PMID 9405296; See PMID 11102532
An16g04210	Catalytic activity: Salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Remark: the salicylate hydroxylase NahW from Pseudomonas stutzeri is involved in mineralization of naphthalene.; Similarity: the protein shows also strong similaritiy to the 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens (patent JP09121864-A).; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An16g04220	Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide; Remark: 2-haloacid halidohydrolases are acting on acids of short-chain lengths, C(2) to C(4), with inversion of configuration at C-2.; Remark: the ORF DNA sequence shows strong similarity to the EST BE760142 from Aspergillus niger.; Title: similarity to 2-haloacid halidohydrolase IVa - Pseudomonas cepacia; See PMID 7684900; See PMID 1376111
An16g04230	Function: Gap1 is the transporter for L-amino acids,4-aminobutyric acid, ornithine, citrulline and some D-amino acids.; Function: the S. cerevisiae homolog GAP1 encodes the low affinitiy, high capacity general aminoacid permease which is responsible for uptake of aminoacids as source of nitrogen when grown on media with limited N supply.; Induction: S. cerevisiae GAP1 expression is induced by growth on poor nitrogen sources.; Localization: Gap1p is sorted differently on different nitrogen sorces. Gap1p is found predominantly internally by growth on rich nitrogen sources. when grown on poor nitrogen sources Gap1p is sorted from the golgi to the plasma membran.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9199164; See PMID 10654085; See PMID 2194797
An16g04240	Title: questionable ORF
An16g04250	Remark: other matches show similarities to CoA ligase-like proteins.; Remark: the matched sequence of patent EP1033405-A2 is a putative protein fragment from Arabidopsis thaliana.; Title: similarity to hypothetical protein from patent EP1033405-A2 - Arabidopsis thaliana
An16g04260	Remark: an alternate name for SPAC29E6. 10c is SPAC30. 14c; Title: strong similarity to hypothetical coiled-coil protein SPAC29E6.10c - Schizosaccharomyces pombe
An16g04270	Function: the protein Vps35 is involved in vacuolar sorting.; Localization: Vps35 is localized at the vacuole, at the endosome and the golgi.; Phenotype: vps35 deletion mutant exhibits defects in sorting of vacuolar carboxypeptidase Y, proteinase A,proteinase B and alkaline phosphatase.; Remark: synonyms for the S. cerevisiae protein Vps35 are Grd9, Vpt7 and YJL154c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps35 - Saccharomyces cerevisiae; vacuole; See PMID 9700157; See PMID 1498362
An16g04280	Remark: Sgs-3 from Drosophila is one of the secreted salivary gland glue polypeptides.; Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to precursor of salivary glue protein sgs-3 - Drosophila yakuba; See PMID 3138416
An16g04290	Title: questionable ORF
An16g04300	Title: questionable ORF
An16g04310	Complex: Tfc6 from S. cerevisiae is the 91 kDa tau91 subunit of transcription factor IIIC (TFIIIC).; Function: Tfc6 from S. cerevisiae is involved in initiation of rRNA and tRNA transcription by RNA-Polymerase III.; Remark: alternate names for S. cerevisiae Tfc6: Tau91, YDR362c.; Title: similarity to RNA polymerase III transcription initiation factor TFIIIC subunit Tfc6 -Saccharomyces cerevisiae; nucleus; See PMID 9418847
An16g04320	Remark: the sequence of the patent EP1033405-A2 from Arabidopsis thaliana was obtained by carrying out RT-PCR on all mRNAs.; Similarity: the ORF encoded protein shows also strong similarity to the hypothetical protein SPAPB24D3. 06c from S. pombe.; Title: strong similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana
An16g04330	Catalytic activity: GDP-mannose + dolichyl phosphate <=> GDP + dolichyl D-mannosyl phosphate.; Function: dolichol phosphate mannose (DPM) synthase activity is required in N-glycosylation, O-mannosylation and glycosylphosphatidylinositol membrane anchoring of protein.; Remark: Trichoderma reesei = Hypocrea jecorina.; Title: strong similarity to mannose phospho-dolichol synthase dpm1 - Hypocrea jecorina; endoplasmatic reticulum; See PMID 11030744
An16g04340	Similarity: the similarities of the protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to protein AF-9 - Homo sapiens
An16g04360	Title: questionable ORF
An16g04370	Title: weak similarity to F-box protein FBP-13 from patent WO200012679-A1 - Homo sapiens
An16g04380	Title: questionable ORF
An16g04390	Title: similarity to a lung cancer associated polypeptide from patent WO200055180-A2 - Homo sapiens
An16g04400	Complex: S. cerevisiae Ntf2 interacts with the small GTPase Ran/Gsp1p.; Function: S. cerevisiae Ntf2 is required for nuclear protein import.; Localization: S. cerevisiae Ntf2 is concentrated at the nuclear envelope.; Title: strong similarity to nuclear transport factor Ntf2 - Saccharomyces cerevisiae; nucleus; See PMID 8702493; See PMID 9199309; See PMID 10889207
An16g04410	Similarity: the ORF shows strong similarity to EST EMBLEST:BE759512 an_2335 - Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC4C5.03 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift
An16g04420	Function: it has been suggested that the S. cerevisiae MSC1 is involved in or regulates the DMC1-promoted interhomologue recombination pathway.; Function: mutations in S. cerevisiae msc1 confer a dominant meiotic lethal phenotype in diploid SPO13 meiosis.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for S. cerevisiae MSC1 is YML128c.; Title: strong similarity to meiotic sister-chromatid recombination protein Msc1 - Saccharomyces cerevisiae; See PMID 10511544
An16g04430	Function: bovine MSBP is a high affinity steroid membrane receptor.; Title: strong similarity to membrane steroid hormone-binding protein MSBP - Bos taurus; plasma membrane; See PMID 10359327; See PMID 11446771
An16g04440	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and threonine rich proteins.
An16g04450	Title: similarity to protein fragment SEQ ID NO:40331 from patent EP1033405-A2 - Zea mays
An16g04460	Complex: hPRP4 interacted directly with Clk1 on its C-terminus.; Function: S. pombe PRP4 is involved in in pre-mRNA splicing.; Function: a recombinant yeast/mouse Prp4 phosphorylates the human SR splicing factor ASF/SF2 in vitro in its RS domain.; Function: human PRP4 is a cyclin-dependent kinase (CDK) like kinase related to MAPKs and due to its activation by EGF may play a distinct role in signal transduction in addition to its role in mRNA processing.; Localization: indirect immunofluorescence analysis revealed that endogenous human hPRP4 was distributed in a nuclear speckled pattern.; Regulation: phosphorylation by Clk1 changes the nuclear distribution of hPRP4.; Similarity: S. pombe PRP4 contains WD repeats.; Similarity: similarity is from the C-terminal half of the predicted A. niger protein to S. pombe PRP4, which is 300 aa shorter.; Title: similarity to pre-mRNA splicing modulating serine/threonine kinase prp4p - Schizosaccharomyces pombe; nucleus; See PMID 8371982; See PMID 9102632; See PMID 9328476; See PMID 10799319; See PMID 11418604
An16g04470	Remark: ORF classified questionable due to lenght below 100 aa, an implausible gene structure with short,multiple Exons and no significant blastp similarity.; Title: questionable ORF
An16g04480	Remark: the predicted ORF is only 85 amino acids long and contains a relatively long intron.
An16g04490	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An16g04500	Complex: S. pombe Ran1 associates with cpc2, Puc1 cyclin and Cdc10 in vivo.; Function: S. pombe Ran1 functions to control the association between the cyclin Puc1 and the Cdc10 transcription complex.; Function: in S. pombe the transition between mitosis and meiosis and the progression through G1 is regulated by Ran1.; Localization: localization of S. pombe Ran1-GFP to the nucleus depends on the scaffolding protein cpc2.; Remark: an alternative name for S. pombe ran1 is pat1.; Title: strong similarity to meiosis control kinase ran1p - Schizosaccharomyces pombe; nucleus; See PMID 3830131; See PMID 9118252; See PMID 9201720; See PMID 10805744
An16g04510	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0311 and AN05G11.; Title: strong similarity to EST an_0311 -Aspergillus niger
An16g04520	Function: HDE from C. tropicalis encodes the peroxisomal trifunctional beta-oxidation enzyme hydratase-dehydrogenase-epimerase (HDE).; Similarity: the sequence match between the two proteins is located within short-chain alcohol dehydrogenase homology regions.; Title: strong similarity to trifunctional enzyme HDE - Candida tropicalis; See PMID 3267241; See PMID 1937002; See PMID 1937003
An16g04530	Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and A. nidulans aflR.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194
An16g04540	Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to hypothetical protein SPBC12C2.09c - Schizosaccharomyces pombe [truncated ORF]
An16g04550	Title: weak similarity to hypothetical cDNA of GTP-binding protein homolog ypt1 - Neurospora crassa; See PMID 1361212
An16g04560	Remark: human CGI-87 was identified by homology to a C. elegans gene.; Title: weak similarity to hypothetical protein CGI-87 - Homo sapiens; See PMID 10810093
An16g04570	Similarity: the predicted A. niger protein shows weak similarity to rat SP120, a nuclear scaffold protein,and to human nuclear ribonucleoprotein hnRNP U.; Title: strong similarity to EST SEQ ID NO:4286 from patent WO200056762-A2 - Aspergillus niger
An16g04580	Function: HSPC021 of H. sapiens interacts with Int-6 (a subunit of the eukaryotic translation initiation factor 3 eIF3) and is associated with the eIF3.; Remark: patent WO200004135-A2 shows strong similarity to the predicted A. niger protein and has been described as human short chain alcohol dehydrogenase (SCAD)-related molecule designated ScRM-2.; Title: strong similarity to hypothetical protein HSPC021 - Homo sapiens; See PMID 11042152; See PMID 11590142
An16g04590	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2591 and an_0945.; Title: strong similarity to EST an_2591 -Aspergillus niger
An16g04600	Function: S. cerevisiae Isa2p is involved in the assembly of iron-sulfur (Fe/S) clusters in mitochondrial and cytosolic proteins.; Localization: according to one reference S. cerevisiae Isa2p is present within the intermembrane space of the mitochondria while according to the second reference it is localised in the mitochondrial matrix as a soluble protein.; Remark: the systematic name for S. cerevisiae ISA2 is YPR067w.; Title: strong similarity to Fe/S cluster assembly factor Isa2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10805735; See PMID 10913600
An16g04630	Catalytic activity: kynureninases convert L-kynurenine + H(2)O to anthranilate + L-alanine.; Function: human kynureninase is involved in the synthesis of NAD (or NADP) from tryptophan.; Regulation: human kynureninase is a pyridoxal-5'-phosphate-(pyridoxal-P)-dependent enzyme.; Title: strong similarity to kynureninase - Homo sapiens; See PMID 10443567
An16g04640	Similarity: the ORF shows strong similarity to EST EMBLEST:BE760042 an_2044 - Aspergillus niger.; Title: strong similarity to hypothetical protein SPCC1281.03c - Schizosaccharomyces pombe
An16g04650	Function: the H. sapiens homolog BAM22 is member of the beta-adaptin family.; Remark: a splice site was detected upstream of the START codon.; Remark: adaptins are important subunits of heterotetrameric complexes called adaptors, which participate in the clathrin-coated, vesicle-mediated endocytosis and intracellular receptor transport.; Title: strong similarity to beta-adaptin BAM22 -Homo sapiens; intracellular transport vesicles
An16g04660	Title: strong similarity to hypothetical protein CAB46758.1 - Schizosaccharomyces pombe
An16g04670	Similarity: strong similarity to expressed sequence tag an_2565 from Aspergillus niger.; Title: strong similarity to hypothetical protein YJL020c - Saccharomyces cerevisiae
An16g04680	Title: similarity to hypothetical protein SPAC23A1.16c - Schizosaccharomyces pombe
An16g04690	Remark: S17B of S. cerevisiae belongs to the S17E family of ribosomal proteins.; Remark: S17B of S. cerevisiae is also called RP51B and YDR447c.; Similarity: the ORF overlaps with EST no:3823 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S17 - Saccharomyces cerevisiae; cytoplasm; See PMID 6092944
An16g04700	Complex: the S. cerevisiae homolog Mrp51p cosediments with the mitochondrial ribosomal small subunit.; Function: deletion of S. cerevisiae MRP51 completely blocks mitochondrial gene expression.; Title: similarity to mitochondrial ribosomal protein of the small subunit Mrp51 - Saccharomyces cerevisiae; localisation:mitochondrion
An16g04710	Similarity: the S. cerevisiae homolog YGL157W shows sequence similarity to a family of ketoreductase genes,capable of reducing a variety of alpha-ketolactones,alpha-ketolactams and diketones.; Title: strong similarity to hypothetical ketoreductase YGL157W from patent EP918090-A2 -Saccharomyces cerevisiae
An16g04720	Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol <=> ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.; Function: the TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. appears to be a central regulator of cell growth.; Pathway: multiple.; Remark: despite significant homology to lipid kinases, the TOR proteins (as well as the other PIKKs) function as Ser/Thr protein kinases.; Similarity: the S. cerevisiae homolog TOR1 belongs to the superfamily of 1-phosphatidylinositol 3-kinase which were found to be the 'target of rapamycin'.; Title: strong similarity to 1-phosphatidylinositol 3-kinase Tor1 - Saccharomyces cerevisiae
An16g04730	Title: similarity to hypothetical protein BAA97377.1 - Arabidopsis thaliana
An16g04750	Remark: The S. griseus homolog strI belongs to the streptomycin (SM) production genes and bears similarity to a number of dehydrogenases.; Title: strong similarity to hypothetical dehydrogenases strI - Streptomyces griseus
An16g04760	Localization: the C. gloeosporioides homolog alr6 is a putative peroxisomal protein.; Title: strong similarity to hypothetical aldehyde reductase 6 alr6 - Colletotrichum gloeosporioides
An16g04770	Function: the S. cerevisisae homolog Gcy1p is an enzyme with NADPH-dependent reductase activity.; Title: strong similarity to aldo/keto reductase Gcy1 - Saccharomyces cerevisiae
An16g04780	Title: similarity to hypothetical protein NUM1 -Arabidopsis thaliana
An16g04790	Similarity: the ORF shows strong similarity to expressed sequence tag an_3044 from Aspergillus niger.; Title: weak similarity to exo-alpha-sialidase -Trypanosoma cruzi
An16g04820	Similarity: the ORF shows strong similarity to expressed sequence tag an_0894 from Aspergillus niger.; Title: strong similarity to hypothetical protein SCD82.04c - Streptomyces coelicolor
An16g04830	Function: the P. chrysogenum homolog pclA is responsible for activation of the penicillin side chain precursor.; Similarity: shows also strong similarity to several 4-coumarate-CoA ligase-like proteins.; Title: strong similarity to phenylacetyl-CoA ligase pclA from patent WO9702349-A1 - Penicillium chrysogenum
An16g04840	Function: the M. grisea homolog Pth11p is a a pathogenicity factor that functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; plasma membrane
An16g04870	Title: similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans
An16g04880	Function: PEX1 of P. chrysogenum encodes a protein of the AAA family of ATPases involved in peroxisomal biogenesis.; Title: strong similarity to peroxin-1 PEX1 -Penicillium chrysogenum; peroxisome; See PMID 10968639
An16g04890	Complex: the MCM proteins form heteromeric complexes with the proteins in a 1:1 stoichiometry.; Complex: the hexameric complex is apparently composed of a subcomplex consisting of a tightly associated core complex (MCM4/6/7) that is loosely associated with MCM2 and a more loosely associated subcomplex, the peripheral dimer (MCM3/5).; Function: the MCM proteins are essential for the initiation of replication and normal S phase progression.; Function: the minichromosome maintenance (MCM) proteins are a family of essential eukaryotic replication proteins with six distinct members (MCM2-MCM7).; Function: the precise molecular function of the MCM protein complex remains to be determined, a recent report showed weak ATPase and DNA helicase activities in the core complex of human MCM4/6/7, which may be regulated by MCM2.; Title: strong similarity to minichromosome maintenance protein mcm7p - Schizosaccharomyces pombe; nucleus; See PMID 10588642
An16g04900	Function: yps-3 of the dimorphic fungus H. capsulatum is expressed in the virulent yeast pahse of this organism, but is silent in the mycelial form of virulent strains.; Title: similarity to yeast phase specific gene yps-3 - Histoplasma capsulatum; See PMID 9673274; See PMID 8012597
An16g04910	Title: strong similarity to hypothetical conserved protein SPCC61.03 - Schizosaccharomyces pombe
An16g04920	Remark: blastp matches are not significant.; Title: weak similarity to ankyrin B - Homo sapiens
An16g04930	Function: The 60S acidic ribosomal protein plays an important role in the elongation step of protein synthesis.; Remark: a splice site was detected upstream of the START codon.; Similarity: this 60S acidic ribosomal protein family includes archaebacterial L12, eukaryotic P0, P1 and P2.; Title: strong similarity to cytoplasmic acidic ribosomal protein P2 - Aspergillus fumigatus; cytoplasm; See PMID 10636918; See PMID 8722011
An16g04940	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S12 AS1 - Podospora anserina; cytoplasm; See PMID 8195128
An16g04950	Title: strong similarity to hypothetical protein SPBP8B7.07c - Schizosaccharomyces pombe
An16g04960	Complex: the arginine-specific carbamoylphosphate synthase of S. cerevisiae is composed of two chains: a small (or glutamine) chain, Cpa1p, and a large (or ammonia) chain, Cpa2p.; Function: in S. cervisiae the small chain promotes the hydrolysis of glutamine to ammonia (EC 6. 3. 5. 5),which is used by the large chain to synthesize carbamoyl phosphate (EC 6. 3. 5. 5).; Pathway: arginine biosynthesis.; Remark: N-terminally truncated due to contig border.; Remark: the systematic genename of CPA2 of S. cerevisiae is YJR109C.; Title: strong similarity to arginine-specific carbamoyl-phosphate synthase subunit Cpa2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 2689869; See PMID 8626695
An16g04970	Catalytic activity: 2 ATP + glutamine + CO(2) + H(2)O = 2 ADP + orthophosphate + glutamate + carbamoyl phosphate; Complex: CPA2 of S. cerevisiae forms a heterodimer with CPA1.; Function: CPA2 of S. cerevisiae accepts the ammonia moiety cleaved from glutamine, binds all the remaining substrates and carries out all the subsequent catalytic events.; Remark: CPA2 of S. cerevisiae is also known as YJR109C.; Title: strong similarity to arginine-specific carbamoyl-phosphate synthase subunit Cpa2 - Saccharomyces cerevisiae; See PMID 11212301; See PMID 6358221; See PMID 8626695
An16g05020	Title: strong similarity to protein vip1p -Schizosaccharomyces pombe; See PMID 10388810
An16g05050	Function: The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.; Title: similarity to importin RanBP7 - Homo sapiens; nucleus; See PMID 9687515; See PMID 10228156
An16g05060	Title: strong similarity to viral mRNA translation inhibitor Ski2 - Saccharomyces cerevisiae
An16g05070	Title: similarity to hypothetical protein SPCC4G3.03 - Schizosaccharomyces pombe
An16g05090	Title: strong similarity to endonuclease SceI 75 kDa subunit Ens1 - Saccharomyces cerevisiae; See PMID 2203771
An16g05120	Title: strong similarity to lovF gene expression regulator At239 from patent WO200257456-A2 - Unclassified organism
An16g05130	Title: similarity to hypothetical protein SPCC4G3.16 - Schizosaccharomyces pombe
An16g05150	Alternative name: Acyl-activating enzyme. Acyl-CoA synthetase. Fatty acid thiokinase (long-chain). Lignoceroyl-CoA synthase.; Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA; Remark: Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).; Title: strong similarity to long-chain-fatty-acid--CoA ligase - Saccharomyces cerevisiae
An16g05190	Title: strong similarity to hypothetical related to meiosis-specific protein NDT80 - Neurospora crassa
An16g05260	Title: strong similarity to eukaryotic translation initiation factor 3 subunit p42 - Homo sapiens; See PMID 9973622
An16g05270	Title: strong similarity to hypothetical protein hsp70 - Neurospora crassa
An16g05290	Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to hypothetical purine-cytosine permease Fcy2 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift
An16g05310	Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An16g05320	Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporortrichoides; See PMID 7651333; See PMID 11352533
An16g05330	Title: strong similarity to hypothetical protein in haematococca pathogenicity cluster PEP2 - Nectria haematococca
An16g05340	Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Title: similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344
An16g05350	Catalytic activity: bifunctional folic acid synthesis protein of P. sativum catalyzes the reactions ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pterid ine (EC 2. 7. 6. 3) and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate <=> diphosphate + dihydropteroate (EC 2. 5. 1. 15).; Pathway: bifunctional folic acid synthesis protein of P. sativum catalyzes the first steps in folate synthesis.; Remark: the A. niger ORF contains a putaive sequncing error at position 7312.; Title: strong similarity to precursor of bifunctional folic acid synthesis protein - Pisum sativum [putative frameshift]; putative frameshift; See PMID 9118956
An16g05370	Function: Glo3p of S. cerevisiae is involved in transition from stationary to proliferative phase.; Title: similarity to zinc-finger protein Glo3 -Saccharomyces cerevisiae; nucleus; See PMID 8070409
An16g05380	Title: similarity to hypothetical membrane protein YGR033c - Saccharomyces cerevisiae
An16g05390	Remark: the A. niger protein also shows weak similarity to the mandelate racemase of Pseudomonas putida and contains a mandelate racemase BLOCKS and PFAM domain.; Title: strong similarity to hypothetical protein RTS-beta - Homo sapiens
An16g05400	Title: similarity to hypothetical protein SPBC839.10 - Schizosaccharomyces pombe
An16g05420	Function: Pgi1p of S. cerevisiae converts glucose-6-phosphate to fructose-6-phosphate.; Phenotype: pgi null mutants are growth-inhibited by glucose.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to glucose-6-phosphate isomerase Pgi1 - Saccharomyces cerevisiae; See PMID 3072254
An16g05430	Title: strong similarity to hypothetical protein EAA58013.1 - Aspergillus nidulans
An16g05450	Remark: the A. niger protein also shows weak similarity to arsenate reductase of S. cerevisiae and to human protein-tyrosine-phosphatase cdc25B.; Title: similarity to hypothetical protein YGR203w -Saccharomyces cerevisiae
An16g05460	Remark: the A. niger protein also shows similarity to the uncharacterized A. thaliana protein from patent EP1033405-A2.; Title: similarity to hypothetical protein MZN14.19 -Arabidopsis thaliana
An16g05470	Title: weak similarity to hypothetical RNA-binding protein - Schizosaccharomyces pombe
An16g05480	Title: weak similarity to calcium/calmodulin-dependent protein kinase IV - Xenopus laevis
An16g05510	Function: galactosyltransferase-associated protein kinase of M. musculus acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone H1, casein, and galactosyltransferase. Galactosyltransferase-associated protein kinase of M. musculus may function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.; Similarity: galactosyltransferase-associated protein kinase of M. musculus shows similarity with the conserved catalytic domains of ser/thr-protein kinases. It belongs to the cdc2/cdkx subfamily.; Title: similarity to galactosyltransferase-associated protein kinase - Mus musculus; deleted EC_number 2.7.1.37; See PMID 2069872
An16g05520	Function: Lys7 of S. cerevisiae is required for the incorporation of copper specifically into superoxide dismutase Sod1p.; Phenotype: lys7 deletion mutant shows sensitivity to superoxide generating drugs, to light irradiation, and diminution of calcineurin activity.; Title: similarity to copper chaperone Lys7 -Saccharomyces cerevisiae; cytoplasm; See PMID 9295278
An16g05550	Function: human neutrophil oxidase factor is involved in the superoxide production by phagocytic cells.; Remark: only the N-terminal half of the A. niger protein is similar to the N-terminal half of the human neutrophil oxidase factor.; Title: similarity to neutrophil oxidase factor -Homo sapiens; See PMID 1692159
An16g05560	Title: strong similarity to hypothetical protein EAA58022.1 - Aspergillus nidulans
An16g05570	Catalytic activity: aspartate aminotransferases convert L-aspartate + 2-oxoglutarate to oxaloacetate + L-glutamate.; Function: aspartate aminotransferases are involved in amino acid and nitrogen metabolism.; Title: strong similarity to aspartate transaminase -Sus scrofa; See PMID 2653435
An16g05580	Remark: the A. niger protein also shows similarity to the RING zinc finger protein of Gallus gallus and contains a zinc finger PFAM domain.; Title: similarity to hypothetical protein B24P11.150 - Neurospora crassa; nucleus
An16g05590	Title: strong similarity to EST an_1462 -Aspergillus niger
An16g05640	Title: similarity to hypothetical protein encoded by An11g07160 - Aspergillus niger
An16g05650	Title: strong similarity to hypothetical protein SC8F11.11c - Streptomyces coelicolor
An16g05660	Catalytic activity: betA of E. coli catalyzes the reaction of choline + acceptor = betaine aldehyde + reduced acceptor.; Function: betA of E. coli catalyzes the oxidation of choline to betaine aldehyde & betaine aldehyde to glycine betaine at the same rate. It is independent of soluble cofactors, and probably electron-transfer-linked.; Pathway: betA of E. coli is involved is the osmoregulatory choline-glycine betaine pathway.; Similarity: betA of E. coli belongs to the GMC oxidoreductases family.; Title: similarity to choline dehydrogenase betA -Escherichia coli; See PMID 1956285
An16g05690	Function: faeA of A. tubingensis is involved in degradation of complex cell wall polysaccharides.; Remark: the ORF encoded protein also shows similarity to methyl ferulate esterase FEA of A. niger from patent WO9814594-A2. FAE can cleave the ester linkage of phenolic esters.; Title: similarity to ferulic acid esterase A faeA -Aspergillus tubingensis; See PMID 9406381
An16g05710	Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Remark: the A. niger protein also shows strong similarity to other cytochrome P450 proteins.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 9501474; See PMID 9683653
An16g05730	Function: Pth11p of M. grisea functions as an upstream effector of appressorium differentiation in response to host surface recognition.; Function: Pth11p of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: Pth11p of M. grisea functions at the cell cortex, but is also found in the vacuolar membrane.; Remark: the A. niger protein is only half the size of Pth11p.; Repression: Pth11p of M. grisea is probably downregulated by shunting the surface receptor protein to the vacuole by endocytosis.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An16g05740	Title: weak similarity to 2-hydroxy-6-ketonona-2,4-dienoate hydrolase hppC - Rhodococcus globerulus
An16g05750	Function: heterologous expression of rice OsMST3 in the yeast S. cerevisiae indicated that OsMST3 has transport activity for some monosaccharides in an energy-dependent H+ co-transport manner.; Title: strong similarity to monosaccharide transporter 3 OsMST3 - Oryza sativa; See PMID 11038054
An16g05760	Catalytic activity: aconitase catalyzes the reaction of citrate to isocitrate and H2O.; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) form. The active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Similarity: aconitate hydratase (aconitase) belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545
An16g05770	Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Remark: the A. niger protein is only half the size of DotA from L. pneumophila. It shows similarity to the C-terminal half of DotA.; Title: similarity to inhibitor of endosome-lysosome fusion DotA - Legionella pneumophila; endosome; See PMID 9632267; See PMID 11207624
An16g05780	Function: UaY of A. nidulans acts as a transcriptional activator of the uapA gene.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421
An16g05790	Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = oxalomesaconate.; Pathway: pcmC of A. keyseri is involved in the phthalate catabolic pathway.; Similarity: the C-terminal half shows very strong homology to a hypothetical protein fragment of A. nidulans.; Title: strong similarity to 2-pyrone-4,6-dicarboxylate hydrolase pcmC - Arthrobacter keyseri; See PMID 11371533
An16g05810	Function: CRG1 of C. nicotianae confers resistance to the photosensitizing toxin cercosporin by a mechanism yet to be determined.; Title: similarity to cercosporin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336
An16g05840	Function: pmaA of A. nidulans is required for proton transport against the transmembrane pH gradient.; Title: strong similarity to plasma membrane H(+)-ATPase pmaA - Aspergillus nidulans; plasma membrane; See PMID 11131024
An16g05880	Function: Mtr1 of N. crassa is required for the cellular uptake of neutral aliphatic and aromatic amino acids.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 7604041; See PMID 8001794
An16g05910	Catalytic activity: Cholesterol + NADPH + O2 = 7-alpha-hydroxycholesterol + NADP(+) + H2O.; Pathway: CYP7 of S. scrofa catalyzes the rate-limiting step in bile acid biosynthesis.; Similarity: belongs to the superfamily of cytochrome P450 monooxygenases.; Title: strong similarity to cholesterol 7alpha-hydroxylase CYP7 - Sus scrofa; See PMID 11013305
An16g05920	Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea
An16g05930	Title: strong similarity to hypothetical protein encoded by An08g06890 - Aspergillus niger
An16g05940	Function: StcS of A. nidulans is involved in the conversion of versicolorin A to demethylsterigmatocystin.; Pathway: StcS of A. nidulans is involved in the sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: belongs to the cytochrome P450 superfamily.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 10618248; See PMID 7486998
An16g05960	Similarity: also shows similarity to some hypothetical epoxide hydrolases.; Similarity: belongs to the alpha/beta hydrolase fold family.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAY08565.; Title: similarity to hydrolase YGJL from patent WO9927081-A2 - Bacillus subtilis
An16g05970	Function: UGT2B11 of H. sapiens catalyzes the transfer of glucuronic acid to a wide range of exogenous and endogenous compounds including phenols derivatives,bilirubin, fatty acids and steroids.; Title: similarity to UDP-glucuronosyltransferase UGT2B11 - Homo sapiens; See PMID 9675083
An16g05990	Title: strong similarity to EST an_3135 -Aspergillus niger
An16g06010	Catalytic activity: 2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate.; Similarity: also shows stronger similarity to a number of putative phosphoglycerate mutases from diverse species.; Title: similarity to phosphoglycerate mutase pgm -Zymomonas mobilis; See PMID 8320209
An16g06020	Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to hypothetical protein CAD87780.1 - Danio rerio [truncated ORF]
An16g06030	Remark: the ORF is N-terminally truncated due to contig border.
An16g06040	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 76 amino acids long.; Title: questionable ORF
An16g06070	Function: PIP of B. coagulans has a higher activity toward small peptides (up to three residues), but very low activity for longer peptides.; Remark: PIP of B. coagulans has no activity on hydroxyproline beta-naphtylamide.; Title: strong similarity to prolyl aminopeptidase PIP - Bacillus coagulans; See PMID 1459939
An16g06090	Phenotype: disruption of the HNM1 locus in S. cerevisiae completely abolished the choline transport activity, indicating that the HNM1 product is the sole choline transporter in yeast.; Remark: HNM1 of S. cerevisiae is also called CTR1.; Repression: the abundance of CTR mRNA in S. cerevisiae significantly decreased on incubation of cells with a combination of choline and myo-inositol; the CTR mRNA level was high in the exponential growth phase but decreased dramatically when cells entered the stationary phase.; Similarity: the ORF shows similarity to several amino acid permeases from different species.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 1878995; See PMID 2203793; See PMID 2249250
An16g06100	Catalytic activity: glutathione S-transferases catalyse RX + glutathione <=> HX + R-S-glutathione.; Function: GST1 of A. suum is facilitating the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophils and can also function as GSH peroxidase.; Title: similarity to glutathione S-transferase GST1 - Ascaris suum
An16g06120	Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178
An16g06130	Title: questionable ORF
An16g06140	Similarity: the C-terminal part of the predicted protein is constituted by low-complexity repeats producing a lot of non significant BLASTP matches.; Similarity: the similarity to B24P11. 210 of N. crassa involves only the N-terminal two thirds of the predicted protein.; Title: strong similarity to hypothetical protein B24P11.210 - Neurospora crassa
An16g06160	Similarity: the similarity to D. melanogaster CG12065 involves only a short N-terminal fragment of the predicted protein.; Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An16g06190	Function: GIT1 of S. cerevisiae is required for uptake of glycerophosphoinositol.; Localization: GIT1 of S. cerevisiae is probably located on the plasma membrane, although the subcellular localization has not been experimentally shown.; Remark: GIT1 of S. cerevisiae is also known as YCR098c.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 9299703; See PMID 9348664; See PMID 9691030
An16g06200	Remark: the predicted ORF encodes a probable transcriptional regulator of the fungal binuclear zinc cluster type.; Title: weak similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987
An16g06210	Catalytic activity: a nitrile + H2O = a carboxylate + NH3.; Catalytic activity: acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Function: for instance in plants the auxin indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile is formed from tryptophan via indole-3-acetaldoxime or indole glycosinolates as the intermediate.; Function: the enzyme acts in a wide range of pathways, like tryptophan metabolism, cyanoamino acid metabolism and nitrogen metabolism.; Title: strong similarity to nitrilase - Alcaligenes faecalis; See PMID 8419930; See PMID 2269298
An16g06220	Function: Lac12 from K. lactis mediates the transport of lactose and it seems that the permease works in part by a proton symport mechanism.; Similarity: the predicted protein has much stronger similarity to the putative hexose transporter htxA of Aspergillus parasiticus.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; plasma membrane; See PMID 3053697; See PMID 10978525
An16g06240	Function: PsADH1 disruption results in a lower growth rate and profoundly greater accumulation of xylitol,therefore PsADH1 likely plays a role in xylose fermentation.; Function: PsADH1 has the ability to convert ethanol to acetaldehyde.; Similarity: the predicted A. niger protein shows similarity to several hypothetical alcohol dehydrogenases and NADPH:quinone oxidoreductases.; Title: similarity to alcohol dehydrogenase PsADH1 -Pichia stipitis; See PMID 9546172
An16g06250	Title: similarity to hypothetical protein encoded by An04g09840 - Aspergillus niger
An16g06260	Title: weak similarity to alkaline serine protease ispQ - Bacillus sp.
An16g06270	Function: A. nidulans verA is a carbonyl reductase which converts the aflatoxin (AF) precursor versicolorin A to sterigmatocystin (ST).; Pathway: A. nidulans verA is involved in the sterigmatocystin synthesis pathway.; Remark: an alternative name for A. nidulans verA is stcU.; Title: similarity to versicolorin reductase verA -Aspergillus nidulans; See PMID 7486998; See PMID 8017929; See PMID 9895285
An16g06290	Remark: blastp with the predicted A. niger protein only retrieves random hits to threonine and proline rich proteins.
An16g06300	Function: S. cerevisiae FET4 is a low affinity Fe(II) and copper permease.; Title: strong similarity to Fe(II) permease Fet4 -Saccharomyces cerevisiae; plasma membrane; See PMID 7929320; See PMID 11023834
An16g06330	Remark: blastp with the predicted A. niger protein only retrieves random hits to proline and threonine rich proteins.
An16g06350	Catalytic activity: delta(6)-desaturass convert linoleoyl-CoA + AH(2) + O(2) to gamma-linolenoyl-CoA + A + 2 H(2)O.; Function: M. rouxii delta(6)-desaturase transforms linoleic acid into Gamma-linolenic acid (GLA) an essential fatty acid.; Title: strong similarity to delta(6)-desaturase -Mucor rouxii; See PMID 11112411
An16g06360	Function: A. flavus omtB converts demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin by transfering a methyl group from donor SAM.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: the A. flavus homologue 'O-methyltransferase B' belongs to the aflatoxin biosynthetic gene cluster.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 6798444; See PMID 10806361
An16g06370	Pathway: TRI4 of Fusarium sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: F. sporotrichioides TRI4 belongs to the cytochrome P450 family CYP58.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides
An16g06380	Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and human SRPK1,which is 400 aa longer.; Similarity: the predicted A. niger protein contains a N-terminal serine/threonine protein kinase domain and shows similarity to serine/threonine protein kinases, most of them SR-family splicing factor specific.; Title: similarity to SR-family splicing factor specific serine/threonine kinase SRPK1 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9472028
An16g06390	Title: strong similarity to hypothetical protein SPAC2C4.17c - Schizosaccharomyces pombe
An16g06400	Function: S. cerevisiae Mgm101p binds to DNA and likely is involved in the repair of oxidatively damaged mtDNA.; Function: S. cerevisiae mgm101 cells were more sensitive to mtDNA damage induced by UV irradiation, gamma rays and H2O2 treatment, while mtDNA packaging, segregation, partitioning or replication were not affected.; Function: the S. cerevisiae (nuclear) mutation mgm101 results in temperature sensitive loss of mitochondrial DNA (mtDNA).; Localization: subcellular fractionation, indirect immunofluorescence and GFP tagging show that S. cerevisiae Mgm101p is exclusively associated with the mitochondrial nucleoid structure in cells.; Title: strong similarity to mtDNA repair protein Mgm101 - Saccharomyces cerevisiae; See PMID 8346025; See PMID 10209025
An16g06410	Function: S. cerevisiae bpl1 mutants are lethal due to the lack of malonyl-CoA-dependent very-long-chain-fatty-acid (VLCFA) synthesis.; Function: biotinylation by S. cerevisiae BPL1 is essential for the assembly of acetyl-CoA-carboxylase (ACC) holoenzyme and in addition affects pyruvate carboxylase and other biotin-containing proteins.; Remark: alternative names for S. cerevisiae BPL1 are ACC2 and YDL141w.; Title: strong similarity to biotin-apoprotein ligase Bpl1 - Saccharomyces cerevisiae; See PMID 7649444; See PMID 9688262
An16g06420	Function: n-alkane-inducible cytochrome P450s catalyze terminal hydroxylation of n-alkanes in the assimilation pathway.; Remark: n-alkane-inducible cytochrome P450s form a multigene family in n-alkane utilising yeast, and show overlapping substrate specifity concerning chain lenght.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica [putative frameshift]; putative frameshift; See PMID 9848230
An16g06430	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An16g06440	Function: the AmdA transcriptional activator from A. nidulans is involved in the induction of the E. nidulans structual gene amdS (acetamidase).; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An16g06450	Function: C. lunatus 17beta-HSDcl catalyses the reduction of steroids and of several o- and p-quinones.; Title: strong similarity to 17beta-hydroxysteroid dehydrogenase 17beta-HSDcl - Cochliobolus lunatus; See PMID 9895285
An16g06460	Title: weak similarity to trithorax homologue 2 MLL2 - Homo sapiens; See PMID 10409430
An16g06470	Function: S. cerevisiae Ayr1p catalyses the NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate.; Function: S. cerevisiae Ayr1p is involved in the biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway.; Function: S. cerevisiae spores bearing the ayr1 defect failed to germinate.; Localization: S. cerevisiae Ayr1p localises to lipid particles and endoplasmic reticulum.; Remark: the systematic name for S. cerevisiae AYR1 is YIL124w.; Title: similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610
An16g06480	Similarity: the predicted A. niger protein contains an epimerase/dehydratase motif.; Title: similarity to hypothetical protein encoded by slr0317 - Synechocystis sp.
An16g06490	Similarity: the predicted A. niger protein contains a dienelactone hydrolase motif.; Title: similarity to glucanase ZmGnsN4 from patent WO200073470-A2 - Zea mays
An16g06500	Function: C. testosteroni mhpA is involved in the degradation of 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway.; Similarity: similarity is from the predicted A. niger protein to the N-terminal 2/3s of C. testosteroni mhpA, which is 160 aa longer.; Title: similarity to 3-(3-hydroxyphenyl)propionate hydroxylase mhpA - Comamonas testosteroni; See PMID 10537203
An16g06510	Similarity: the predicted A. niger protein shows similarity to several predicted methyltransferases and contains a strong methyltransferase motif.; Title: similarity to protein involved in biotin biosynthetis BioC - Kurthia sp.; See PMID 11255013
An16g06530	Function: C. lagenarium cmr1Delta mutants do not express the melanin biosynthetic structural genes SCD1 and THR1 during mycelial melanization although the expression of these two genes was not affected during appressorial melanization.; Similarity: C. lagenarium CMR1 is unique in that it contains two distinct DNA-binding motifs, a Cys2His2 zinc finger motif and a Zn(II)2Cys6 binuclear cluster motif.; Title: similarity to transcription activator CMR1 -Colletotrichum lagenarium; nucleus; See PMID 11123670
An16g06540	Function: guinea pig zeta-crystallin has been characterized as an NADPH:quinone oxidoreductase (EC 1. 6. 5. 5), while bovine CRYZ shows minimal quinone oxidoreductase activity but strong binding affinity to single-stranded DNA (ssDNA) that could be competed with NADPH.; Similarity: the predicted A. niger protein shows similarity to several predicted zinc-binding oxidoreductases.; Title: similarity to zeta-crystallin CRYZ - Bos taurus; See PMID 9154917
An16g06550	Title: weak similarity to hypothetical mitomycin biosynthetic cluster protein MmcO - Streptomyces lavendulae; See PMID 10099135
An16g06560	Catalytic activity: glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Function: glutaryl 7-ACA acylase is one of the two enzymes involved in the biotransformation of cephalosporin C (CefC) into 7-aminocephalosporanic acid (7-ACA).; Remark: 7-aminocephalosporanic acid (7-ACA) is the primary substrate for the industrial synthesis of semisynthetic cephalosporins as beta-lactam antibiotics.; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 8181946; See PMID 11080627; See PMID 1744041
An16g06570	Remark: blastp with the predicted A. niger protein only retrieves random hits to alanine rich proteins.
An16g06580	Function: A. nidulans QUTD encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5.; Function: mutations in the qutD gene of A. nidulans cause the loss of ability to grow upon quinic acid as sole carbon source in media at pH 6. 5 and failure to induce three enzyme activities specifically required for metabolism to protochatechuic acid.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880
An16g06590	Function: A. aculeatus beta-1,4-galactanase degrades unsubstituted galactan to galactose and galactobiose.; Remark: the A. niger protein could have been predicted with a 1. Exon that is nearly identical to the 1. Exon of A. aculeatus beta-1,4-galactanase, but contains several stop codons. Instead of modeling the A. niger protein as a pseudogene it was modeled with a new 1. Exon.; Title: strong similarity to beta-1,4-galactanase -Aspergillus aculeatus [putative pseudogene]; extracellular/secretion proteins; See PMID 7788716
An16g06600	Title: weak similarity to beta-galactosidase -Planococcus sp.; See PMID 10831422
An16g06610	Function: in K. lactis disruption of hgt1 confered much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Regulation: in K. lactis expression of HGT1 is constitutive.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An16g06620	Function: F. oxysporum lactonohydrolase hydrolyses aldonate lactones to the corresponding aldonic acids.; Title: strong similarity to lactonohydrolase from patent WO200028043-A2 - Fusarium venenatum; See PMID 9788992
An16g06630	Catalytic activity: C. testosteroni bphB converts cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) to biphenyl-2,3-diol + NADH.; Function: C. testosteroni bphB catalyzes the second step in the biphenyl degradation pathway.; Remark: EC 1. 3. 1. 56 (net in EC number cat yet).; Title: similarity to 2,3-dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase bphB - Comamonas testosteroni; See PMID 8702262
An16g06640	Function: A. nidulans facB is a major regulatory gene involved in acetamide and acetate utilisation and is required for growth on acetate as a sole carbon source.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and A. niger facB,which contain the Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408
An16g06650	Similarity: the predicted A. niger protein contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding motif.; Title: weak similarity to zinc-finger protein zas1p - Schizosaccharomyces pombe; nucleus; See PMID 10718196
An16g06660	Title: weak similarity to constituent of COPII coats Sfb2 - Saccharomyces cerevisiae; See PMID 10749860
An16g06670	Title: weak similarity to hypothetical protein CAC10504.1 - Pseudonocardia sp.
An16g06680	Title: weak similarity to hypothetical protein VC2566 - Vibrio cholerae
An16g06690	Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster
An16g06710	Function: ankyrins link the spectrin-based membrane skeleton to the plasma membrane.; Title: similarity to ankyrin 1 - Mus musculus; cytoskeleton; See PMID 8486643
An16g06720	Function: C. carbonum HTS is a multifunctional peptide synthase, able to activate the amino acids pro,l-ala, d-ala and aeo (2-amino-9,10- epoxi-8-oxodecanioc acid), and epimerize pro and l-ala.; Title: strong similarity to HC-toxin peptide synthase HTS - Cochliobolus carbonum; See PMID 1281482
An16g06730	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An16g06740	Remark: YCF1 of S. cerevisiae is required for cadmium resistance.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: YCF1 of S. cerevisiae belongs to superfamily of human multidrug resistance protein cMOAT2.; Similarity: similar to ATP-binding cassette transporters.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 7521334
An16g06750	Catalytic activity: D-amino acid amides and methyl esters also are hydrolysed, as is glycine amide.; Catalytic activity: Release of an N-terminal D-amino acid from a peptide, Xaa-|-Xaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr.; Similarity: also similar to several beta-lactamases.; Title: similarity to D-stereospecific aminopeptidase - Ochrobactrum anthropi; See PMID 2760064
An16g06760	Function: Overexpression of RTM1 in yeast confers resistance to the toxicity of molasses.; Similarity: Also similar to 7-aminocholesterol resistance protein RTA1 of S. cerevisiae.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593
An16g06770	Function: TAT1 of R. norvegicus facilitates Na+ -independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine.; Similarity: also similar to H+/monocarboxylate transporters.; Title: strong similarity to T-type amino acid transporter 1 TAT1 - Rattus norvegicus; See PMID 11278508
An16g06780	Function: CHA4 of S. cerevisiae activates CHA1 by binding to UAS1(CHA) and UAS2(CHA) elements in the CHA1 promoter.; Remark: CHA4 of S. cerevisiae belongs to unassigned GAL4-type zinc cluster proteins.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae
An16g06790	Title: similarity to hypothetical protein Rv0272c -Mycobacterium tuberculosis
An16g06800	Catalytic activity: eglB of A. niger catalyzes the endohydrolysis of 1,4-beta-d-glucosidic linkages in cellulose.; Function: eglB of A. niger has carboxylmethylcellulase activity.; Similarity: eglB of A. niger belongs to cellulase family h (family 12 of glycosyl hydrolases).; Title: strong similarity to endoglucanase eglB -Aspergillus niger; See PMID 9758775
An16g06810	Title: strong similarity to hypothetical protein YGR127w - Saccharomyces cerevisiae
An16g06820	Title: strong similarity to hypothetical pathogenicity protein PATH531 - Magnaporthe grisea
An16g06840	Similarity: similarity only to repetetive sequences.
An16g06850	Function: eIF-4F of S. cerevisiae is a 150K subunit of a mRNA cap-binding protein.; Remark: In S. cereviae TIF4631 is probably essential when TIF4632 is missing.; Similarity: similarity to mammalian translation initiation factor eIF-4 gamma.; Title: strong similarity to translation initiation factor eIF-4F Tif4631 - Saccharomyces cerevisiae
An16g06860	Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to hypothetical protein SPBC25B2.10 - Schizosaccharomyces pombe [truncated ORF]
An16g06890	Similarity: the weak similarity to fibrinogen-binding protein of S. aureus is due to a dipeptide repeats region.; Title: weak similarity to fibrinogen-binding protein - Staphylococcus aureus
An16g06910	Title: questionable ORF
An16g06940	Function: Trk1 of S. occidentalis is also involved in the control of the membrane potential.; Remark: putative frameshift due to possible sequencing error.; Similarity: the Trk proteins show significant similarity to the high affinity K+ transporter (HKT1p) from wheat roots which seems to act as a K+-Na+ co-transporter.; Similarity: the protein shows strong similarity to the TRK family of high affinity potassium transporters,represented in several fungal species.; Title: strong similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis [putative frameshift]; plasma membrane; putative frameshift; See PMID 10931360
An16g06950	Function: JEN1 of S. cerevisiae is a lactate and pyruvate proton-driven symporter.; Induction: JEN1 of S. cerevisiae is induced by lactate.; Phenotype: Deletion of JEN1 in S. cerevisiae results in slow growth of yeast on synthetic medium supplemented with L-lactate.; Repression: JEN1 of S. cerevisiae is repressed by glucose.; Similarity: JEN1 of S. cerevisiae belongs to the sialate:H+ symporter (SHS) group of the major facilitator superfamily (MFS) of transport proteins.; Similarity: the protein shows a very strong similarity to a N. crassa gene, related to S. cerevisiae JEN1 as well.; Title: strong similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10198029
An16g06980	Remark: ORF classified as questionable because on the opposite DNA strand, in the C terminal part of the encoded protein, there are promoter elements of the pgaA gene An16g06990.; Similarity: nucleotides 1-1161 of the predicted ORF are identical to the reverse complement of the promoter region of the pgaA gene of A. niger.; Title: questionable ORF
An16g06990	Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: degradation of the homogalacturonan part of the pectin molecule.; Gene-ID: pgaA;ppaS; Mapping: pgaA from A. niger is mapped to chromosome V; see EMBL Y18804.; Remark: a putative N-glycosidation site is located at Asn214 of the mature protein, and is strictly conserved in many characterized A. niger polygalacturonases.; Remark: a putative sequencing error results in an frameshift.; Remark: the enzyme is most likely synthesized as prepro-enzyme, and the signal peptide is probably cleaved at Ala19.; Similarity: pgaA belongs to the polygalacturonases (pga) gene family, consisting, in A. niger, of seven different genes.; extracellular/secretion proteins; putative frameshift; See PMID 1511691; See PMID 10642523
An16g07020	Function: ArcA of A. nidulans might be involved in the regulation of arginine catabolic pathway (unpublished).; Title: similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans; See PMID 62492
An16g07030	Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered.; Similarity: several putative dehydrogenases with possible different specificities show strong similarity to this protein.; Similarity: similarity to lovC of A. terreus is due to the zinc-binding dehydrogenase domain.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An16g07040	Remark: N-terminally truncated ORF due to contig border; Similarity: BGT1 of A. fumigatus is similar to the glucan 1,3-beta-glucosidase BGL2 of S. cerevisiae.; Similarity: other similarities are due to repetitive Thr motifs.; Similarity: the protein shows much stronger similarity to several putative membrane proteins of S. cerevisiae.; Title: similarity to beta-1,3-glucanosyltransferase bgt1 - Aspergillus fumigatus [truncated ORF]; cell wall; See PMID 9846753
An16g07050	Title: weak similarity to hypothetical clone:C630039G13 - Mus musculus [truncated ORF]
An16g07060	Similarity: the predicted ORF shows a local weak similarity to a putative permease of Serpulina hyodysenteriae.
An16g07080	Similarity: the predicted ORF shows a very weak similarity to con-8 of N. crassa, a protein with unknown molecular function, which is expressed during conidiation.
An16g07090	Pathway: 3-oxoacyl-(acyl-carrier protein) reductases are involved in the fatty acids biosynthesis.; Remark: the patentmatch is against a protein entry,which represent the proteins encoded by all the open reading frames in the complete genome of C. pneumoniae.; Remark: the polypeptides encoded by the open reading frames of the C. pneumoniae genome can be used in immunogenic compositions as vaccines.; Similarity: protein sequence of patent WO9927105-A2 is almost identical to the putative 3-oxoacyl-(acyl-carrier protein) reductase CP0462 of C. pneumoniae.; Similarity: the predicted ORF shows similarity to the ribitol dehydrogenase superfamily, containing a short-chain alcohol dehydrogenase domain.; Title: similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae
An16g07110	Catalytic activity: acetyl-CoA + H2O = CoA + acetate.; Function: the acetyl-CoA hydrolase is presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.; Induction: ACH1 of S. cerevisiae is highly expressed during sporulation.; Repression: catalytic activity of ACH1 of S. cerevisiae is inhibited by Zn2+, and gene expression is repressed by glucose. .; Similarity: the predicted ORF shows local identities with several A. niger ESTs, e. g. : EMBLEST:BE759170.; Similarity: the predicted ORF shows strong similarity to the acetyl-CoA hydrolase of different species and to N. crassa acu-8.; Title: strong similarity to acetyl-CoA hydrolase Ach1 - Saccharomyces cerevisiae; See PMID 8841387; See PMID 1970569; See PMID 2570693
An16g07120	Complex: SIN3 of S. cerevisiae is part of a large multiprotein complex that includes the Rpd3 histone deacetylase.; Function: as part of the histone deacetylase complex, SIN3 of S. cerevisiae is required both for activation and repression of diverse genes, involved in a variety of important cellular processes.; Localization: SIN3 of S. cerevisiae is a nuclear protein, possibly linked to centromere.; Remark: SIN3 of S. cerevisiae is also known as rpd1,ume4, gam2, sdi1, YOL004W, CPE1, or SDS16.; Similarity: the predicted ORF contains three paired amphipathic helix repeats, domains which may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.; Title: strong similarity to regulator protein Sin3 -Saccharomyces cerevisiae; nucleus; See PMID 9651585; See PMID 10809695; See PMID 1944290; See PMID 2233725
An16g07130	Function: microscopic and genetic analyses indicate that rgb-1 is a regulator of the budding subroutine of the macroconidiation process and that arthroconidiation, which shares common early and late events with macroconidiation,is induced as a default mechanism for asexual reproduction in this fungus.; Remark: alternative splicing known for N. crassa protein.; Title: strong similarity to phosphatase 2A regulatory B subunit rgb-1 - Neurospora crassa
An16g07140	Similarity: similarity results from high content of repetitive sequences.; Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans
An16g07150	Cofactor: noncovalently bound FAD.; Function: FRDS1 of S. cerevisiae catalyzes the reduction of fumarate to succinate.; Similarity: shows stronger similarity to hypothetical enzymes of S. pombe and L. major.; Title: strong similarity to soluble cytoplasmic fumarate reductase YEL047c - Saccharomyces cerevisiae; cytoplasm; See PMID 8946166; See PMID 8953036; See PMID 9587404
An16g07170	Function: FUM5 is required for fumonisin biosynthesis.; Function: contains a domain typical for Zinc-binding dehydrogenases.; Remark: putative frameshift might be caused by sequencing error.; Similarity: shows only partial similarity to FUM5.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis [putative frameshift]; putative frameshift; See PMID 10413619
An16g07180	Function: VDH is an enzyme for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications.; Title: strong similarity to vanillin dehydrogenase VDH from patent EP0845532 - Unclassified organism
An16g07200	Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: shows only partial similarity to pth11p.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An16g07210	Function: COP8 of A. thaliana is involved in photomorphogenesis.; Similarity: very high similarity to unpublished COP9 signalosome protein of A. nidulans.; Title: strong similarity to COP9 signalosome chain COP8 - Arabidopsis thaliana
An16g07220	Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II.; Title: strong similarity to beta subunit of transcription initiation factor TFIIF Tfg2 - Saccharomyces cerevisiae; nucleus; See PMID 9845373
An16g07230	Function: SIP2 contains an RNAase activity,providing a link between TGF-beta signal transduction and mRNA stabilisation.; Remark: SIP2 is from PatentDNA.; Similarity: shows only partial similarity to SIP2.; Similarity: shows similarity to several hypothetical proteins containing zinc-finger domains.; Title: similarity to SMAD interacting protein SIP2 from patent WO9855512-A2 - Mus musculus
An16g07250	Similarity: blast hits result from repetitive sequences.; Title: weak similarity to hypothetical protein CG14713 - Drosophila melanogaster
An16g07260	Function: the H. sapiens homolog E-MAP-115 is a microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2321, 1979 and 1980.; Similarity: similarity is from a N-terminal laying region of the predicted A. niger protein to a C-terminal region of human E-MAP-115.; Similarity: the predicted A. niger protein contains a basic helix-loop-helix DNA binding motif.; Title: weak similarity to epithelial microtubule-associated protein E-MAP-115 - Homo sapiens
An16g07280	Function: S. pombe Nif1 inhibits mitosis by inhibiting Nim1-mediated phosphorylation and inhibition of Wee1, whose activity inhibits Cdc2/Cdc13 cyclin-dependent kinase.; Title: similarity to mitotic inhibitor nif1p -Schizosaccharomyces pombe; See PMID 9135149
An16g07290	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_1922, an_1665 and an_2380.; Title: strong similarity to F1Fo-ATP synthase subunit 4 ATP4 - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9790576
An16g07300	Title: strong similarity to polypeptide SEQ ID NO:5295 from patent WO200171042-A2 - Drosophila melanogaster
An16g07320	Title: weak similarity to hypothetical transcriptional regulator CC1412 - Caulobacter crescentus
An16g07330	Title: weak similarity to hypothetical extracellular matrix protein AAL47843.1 - Fusarium oxysporum
An16g07340	Remark: alternative names for human CEP2 are CEP250 and centrosomal Nek2-associated protein 1 (C-NAP1).; Similarity: similarity is from the predicted A. niger protein to several regions of human CEP2, which is 2100 aa longer.; Title: weak similarity to Cdc42 effector CEP2 - Homo sapiens; See PMID 11035016
An16g07350	Remark: blastp with the predicted A. niger protein likely only retrieves random hits to serine rich proteins.; Title: weak similarity to gastric mucin - Sus scrofa
An16g07360	Function: a role for mouse Mms19 protein in the assembly of a multiprotein complex(es) required for NER and RNAP II transcription has been suggested.; Function: mouse MMS19 is a polypeptide of unknown function which is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription.; Title: strong similarity to MMS19 - Mus musculus; See PMID 11328871
An16g07370	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST Nig076 .; Title: similarity to hypothetical protein SPBC146.10 - Schizosaccharomyces pombe
An16g07380	Title: strong similarity to hypothetical cDNA MGC:7080 - Mus musculus
An16g07390	Complex: S. cerevisiae SPC associates with Sbh1p and Sbh2p, the beta-subunits of the Sec61p complex and the Ssh1p complex, respectively.; Complex: in S. cerevisiae the SPC is formed by a heterotetramer of Sec11p, Spc3p, Spc1p and Spc2p.; Function: S. cerevisiae Spc2 is a subunit of the endoplasmatic reticulum signal peptidase complex, and is homologous to the mammalian protein SPC25.; Function: S. cerevisiae Spc2p not only enhances the enzymatic activity of the SPC but also facilitates the interactions between different components of the translocation site.; Function: mutations in S. cerevisiae Spc2 only disrupt signal peptidase complex (SPC) activity at high temperatures.; Remark: alternative names for S. cerevisiae SPC2 are SPY1 andYML055w.; Title: strong similarity to endoplasmatic reticulum signal peptidase subunit Spc2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8910564; See PMID 10921929
An16g07400	Catalytic activity: Methylenetetrahydrofolate dehydrogenases convert 5,10-methylenetetrahydrofolate + NAD(+) to 5,10-methenyltetrahydrofolate + NADH.; Function: S. cerevisiae MTD1 is involved in the oxidation of cytoplasmic one-carbon units for the de novo purine biosynthesis.; Regulation: S. cerevisiae MTD1 expression is repressed by adenine and requires the transcription factors Baslp and Bas2p.; Remark: the 5'UTR of the predicted A. niger protein is covered by the A. niger EST an_2989 .; Title: strong similarity to NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase Mtd1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8416923; See PMID 8608153; See PMID 9749667
An16g07410	Remark: in S. cerevisiae three copies of the ATP1 gene exist on Chr. II within a 20kb region.; Title: strong similarity to mitochondrial F1-ATPase alpha-subunit Atp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8690725; See PMID 2876995
An16g07420	Remark: according to A. niger EST an_3502 a possible sequencing error occured at position 45296 leading to a missing splice site, 1 base has been changed from G to A.; Title: strong similarity to hypothetical protein AAF27107.1 - Arabidopsis thaliana [putative sequencing error]
An16g07430	Complex: in S. pombe the DNA-dependent RNA-polymerase II consists of 11 subunits, RPBs 1-8 and 10-12, with the large subunits Rpb1+2 forming the scaffold for the assemlby of the smaller subunits.; Function: RNA polymerase II of S. pombe catalyses DNA-template-directed extension of the 3'-end of an mRNA strand by one nucleotide at a time.; Title: strong similarity to 19 kD subunit of DNA-directed RNA polymerase II rpb7p - Schizosaccharomyces pombe; nucleus; See PMID 9322754; See PMID 9642054
An16g07440	Title: similarity to hypothetical protein B23L4.080 - Neurospora crassa
An16g07450	Function: N. crassa QDE2 controls transgene-induced gene silencing.; Function: the Drosophila QDE2 homologue, dAGO1,exerts its developmental functions by binding to RNA either directly or indirectly.; Function: the rabbit QDE2 homologue, eIF2C, forms part of a protein complex that stimulates the start of translation.; Localization: the rat QDE2 homologue, GERp95, is a cytoplasmically exposed peripheral membrane protein that exists in a protease-resistant complex and localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type.; Title: strong similarity to protein involved in post-transcriptional gene silencing QDE2 - Neurospora crassa; See PMID 10512872; See PMID 10749199; See PMID 11318874
An16g07460	Remark: an alternative name for A. niger acuB is facB.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720
An16g07470	Function: S. pombe gar2 helps the assembly of pre-ribosomal particles containing 18S rRNA.; Function: S. pombe gar2 helps the assembly on rRNA of factors necessary for 40S subunit synthesis by providing a physical link between them.; Localization: S. pombe gar2 has a nucleolar localization.; Title: similarity to mediator of 40S ribosomal subunit assembly gar2p - Schizosaccharomyces pombe; nucleus; See PMID 7596817; See PMID 9693363
An16g07480	Complex: Y. lipolytica Pay32p in the matrix is complexed with two polypeptides of 62 and 64 kD recognized by antibodies to SKL (peroxisomal targeting signal-1).; Function: Y. lipolytica PAY32 binds to the C-terminal pts1-type tripeptide peroxisomal targeting signal (skl-type) and plays an essential role in peroxisomal protein import.; Function: Y. lipolytica pay32 mutants fail to assemble functional peroxisomes.; Function: mutations in Y. lipolytica PAY32 prevent the translocation of most peroxisome-bound proteins into the peroxisomal matrix, these proteins instead are trapped in the peroxisomal membrane at an intermediate stage of translocation.; Localization: Y. lipolytica Pay32 is intraperoxisomal, associated primarily with the inner surface of the peroxisomal membrane, but approximately 30% of Pay32p is localized to the peroxisomal matrix.; Title: strong similarity to peroxisomal matrix protein importer PAY32 - Yarrowia lipolytica; peroxisome
An16g07490	Catalytic activity: 2-hydroxyphytanoyl-CoA lyases convert 2-hydroxyphytanoyl-CoA to pristanal.; Cofactor: human 2-hydroxyphytanoyl-CoA lyase depend on Mg(2+) and thiamine pyrophosphate.; Function: human 2-hydroxyphytanoyl-CoA lyase catalyses the second step of the alpha-oxidation of 3-methyl-branched fatty acids such as phytanic acid,catalysing a carbon-carbon cleavage.; Title: strong similarity to 2-hydroxyphytanoyl-CoA lyase - Homo sapiens; peroxisome; See PMID 10468558
An16g07500	Catalytic activity: amidases convert a monocarboxylic acid amide + H2O to a monocarboxylate + NH3.; Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667; See PMID 7847883; See PMID 9044292
An16g07510	Title: similarity to hypothetical protein F13M7.11 -Arabidopsis thaliana
An16g07520	Catalytic activity: cystein synthases convert O3-acetyl-L-serine + H(2)S to L-cysteine + acetate.; Title: strong similarity to cysteine synthase cysK -Rhodobacter sphaeroides; See PMID 9406390
An16g07530	Title: weak similarity to hypothetical chromodomain-helicase-dna-binding protein CHD-2 - Homo sapiens
An16g07540	Function: mouse beclin has autophagy-promoting activity and is associated with inhibition of tumourgenesis and antiviral host defense.; Title: strong similarity to bcl-2-interacting protein beclin - Mus musculus; See PMID 9765397; See PMID 10604474
An16g07550	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An16g07560	Title: strong similarity to transposase Tan1 -Aspergillus niger [putative frameshift]; putative frameshift; See PMID 9003286
An16g07580	Title: strong similarity to EST an_2194 -Aspergillus niger
An16g07600	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An16g07610	Complex: P. pastoris Pex13p together with Pex14p and Pex17p forms the peroxisomal translocation machinery.; Function: P. pastoris Pex13p binds the PTS1 receptor (Pex5p) via a cytoplasmically oriented SH3 domain.; Function: P. pastoris Pex13p is a component of the peroxisomal translocation machinery.; Function: loss of P. pastoris Pex13p eliminates import of peroxisomal matrix proteins that contain either the type-1 or type-2 peroxisomal targeting signal but does not affect targeting and insertion of integral peroxisomal membrane proteins.; Localization: P. pastoris Pex13p is an integral peroxisomal membrane protein.; Similarity: P. pastoris Pex13p contains a SH3 domain.; Title: strong similarity to peroxisomal docking factor Pex13 - Pichia pastoris; peroxisome; See PMID 8858165
An16g07620	Complex: S. cerevisiae Ero1 is a FAD-binding protein and binds to PDI.; Function: S. cerevisiae Ero1 is required for correct folding of disulfide-bonds containing proteins in the ER.; Function: S. cerevisiae Ero1 oxidises protein disulfide isomerase (PDI) via direct dithiol-disulfide exchange, which in turn oxidises disulfide-bond containing proteins in the ER.; Remark: the systematic name for S. cerevisiae Ero1 is YML130c.; Title: strong similarity to endoplasmatic reticulum oxidising protein Ero1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9659913; See PMID 10549279; See PMID 11090354
An16g07630	Title: weak similarity to hypothetical protein YDR348c - Saccharomyces cerevisiae
An16g07640	Title: strong similarity to hypothetical protein FLJ13154 - Homo sapiens
An16g07650	Remark: a putative sequencing error results in a frameshift.; Title: weak similarity to hypothetical membrane protein YLR106c - Saccharomyces cerevisiae [putative frameshift]; putative frameshift
An16g07660	Function: B abortus gluP is a glucose and galactose transporter.; Remark: C-terminal region and 3'UTR of the predicted A. niger protein are in accordance with the A. niger EST an_2695 EMBLEST:BE759781.; Similarity: B abortus gluP is a member of the major facilitator superfamily.; Title: similarity to glucose and galactose transporter gluP - Brucella abortus; See PMID 9168605
An16g07680	Function: N. crassa mtr is required for neutral,aliphatic and aromatic amino acid transport across the plasma membrane.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345
An16g07690	Remark: an A. niger EST ID NO:4166, PATENTDNA:F11643, covers the 5'UTR and the N-terminus of the predicted A. niger protein.; Title: similarity to hypothetical protein B2I10.030 - Neurospora crassa
An16g07700	Catalytic activity: dihydrodipicolinate synthases convert l-aspartate 4-semialdehyde + pyruvate to dihydrodipicolinate + 2 H(2)O.; Complex: C. glutamicum dapA forms a homotetramer.; Function: C. glutamicum dapA catalyses the first step in the biosynthesis of diaminopimelate and lysine from aspartate semialdehyde.; Repression: C. glutamicum dapA is sensitive to lysine inhibition.; Similarity: C. glutamicum dapA belongs to the dhdps family.; Title: similarity to dapA - Corynebacterium glutamicum; See PMID 8092856; See PMID 2129555
An16g07710	Catalytic activity: carboxylesterases convert a carboxylic ester + H(2)O to an alcohol + a carboxylic anion.; Function: Rhodococcus cocE does initiate degradation of cocaine for the utilisation as carbon and nitrogen source.; Title: similarity to cocaine esterase cocE -Rhodococcus sp.; See PMID 10698749
An16g07720	Title: weak similarity to outer surface protein D ospD - Borrelia garinii
An16g07740	Remark: ORF 3'truncated due to end of contig.; Title: similarity to hypothetical protein T18N14.80 - Arabidopsis thaliana [truncated ORF]
An16g07795	Title: strong similarity to hypothetical protein CAC18184.2 - Neurospora crassa
An16g07800	Catalytic activity: ADP + ATP <=> phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.; Catalytic activity: GTP and adenosine tetraphosphate can also act as adenylyl acceptors.; Function: APA2 of S. cerevisiae sustains the catabolism of NP-4-N' nucleotides, rather than their synthesis.; Title: strong similarity to ATP adenylyltransferase Apa2 - Saccharomyces cerevisiae; See PMID 11007995; See PMID 2174863
An16g07830	Similarity: weak local similarity to probable two-component sensor histidine kinase yocF - Bacillus subtilis.
An16g07840	Remark: M protein of S. pyogenes binds also human serum albumin and fibrinogen.; Remark: M protein of S. pyogenes is a major antigenic determinant which binds human IgG1, IgG2, IgG3 and IgG4, as well as horse, rabbit and pig IgG in a non-immune fashion.; Title: similarity to M protein emm55 - Streptococcus pyogenes; See PMID 7643859
An16g07850	Function: snRPG of H. sapiens is associated with small nuclear ribonucleoproteins (sn-RNP) U1, U2 U4/U6 and U5, necessary for mRNA splicing.; Remark: in humans, snRNPs represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE).; Similarity: the predicted ORF belongs to the snRNP Sm proteins family.; Title: strong similarity to small nuclear ribonucleoprotein G snRPG - Homo sapiens; nucleus; See PMID 7744013
An16g07860	Complex: TFIID of S. cerevisiae is composed of TBP,the TATA box binding protein, and 14 distinct TBP-associated factors (TAFs), which range in size from 17 to 150 kDa.; Complex: TSM1 of S. cerevisiae is a component of the TFIID general RNA polymerase II transcription factor complex.; Function: TFIID binding is thought to be the first step in transcription initiation, acting to nucleate the transcription complex, recruiting the rest of the factors through a direct interaction with TFIIB.; Phenotype: TSM1 null mutants of S. cerevisiae are inviable.; Remark: TSM1 of S. cerevisiae is also called TAF150 or YCR042C.; Title: strong similarity to subunit of transcription initiation factor TFIID Tsm1 - Saccharomyces cerevisiae; nucleus; See PMID 8178153; See PMID 10721692; See PMID 10788514; See PMID 1840512
An16g07870	Catalytic activity: CDP-ethanolamine + 1,2-diacylglycerol <=> CMP + a phosphatidylethanolamine.; Function: AAPT1 of G. max (soybean) shows substrate specificity both for CDP-choline and CDP-ethanolamine.; Function: aminoalcoholphosphotransferases (AAPTases) utilize diacylglycerols and cytidine diphosphate (CDP)-aminoalcohols as substrates in the synthesis of the abundant membrane lipids phosphatidylcholine and phosphatidylethanolamine.; Localization: the diacylglycerol cholinephosphotransferase CPT1 of S. cerevisiae is located in the endoplasmic reticulum.; Similarity: the predicted ORF shows strong similarity to various aminoalcoholphosphotransferases of yeasts, plants and animals.; Title: strong similarity to aminoalcoholphosphotransferase AAPT1 - Glycine max; See PMID 7994181
An16g07890	Function: pro1 is essential in S. macrospora for the formation of multicellular fruiting bodies called perithecia.; Similarity: strong similarity to the predicted zinc-finger protein 17E5. 150 of N. crassa.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the similarity to pro1 of S. macrospora is due to the conserved fungal zinc-finger motiv.; Title: similarity to transcription factor pro1 -Sordaria macrospora; See PMID 10224253
An16g07900	Function: HNM1 of S. cerevisiae is the unique coline permease in yeast (Km of 0. 5 micromolar).; Phenotype: the ctr1 mutant is defective in choline and ethanolamine transport, but the mutation also confers hyper-resistance to the alkylating agent nitrogen mustard.; Regulation: in S. cerevisiae, expression of CTR1/HNM1 is regulated by the phospholipid precursors inositol and choline and this regulation involves the trans-acting factors Ino2p, Ino4p and Opi1p.; Regulation: in S. cerevisiae, the choline transport activity decreases upon addition of choline to the growth medium.; Remark: HMN1 of S. cerevisiae is also known as CTR1.; Similarity: HNM1 of S. cerevisiae belongs to the APC family, which encompasses amino acid permeases more related to the mammalian cationic amino-acid transporter family (Tea/ecoR).; Similarity: the protein also shows strong similarity to the putative GABA permease GabA of Aspergillus nidulans; the gene structure is very different.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8264542; See PMID 2203793; See PMID 7520996
An16g07910	Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to protein fragment SEQ ID NO:32794 from patent EP1033405-A2 - Arabidopsis thaliana
An16g07920	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein EAA64623.1 - Aspergillus nidulans
An16g07930	Title: strong similarity to hypothetical protein encoded by An12g06140 - Aspergillus niger
An16g07940	Complex: FUS6 of A. thaliana is a component of the COP9 complex, which is a multi subunit protein conserved in plants and animals.; Complex: the COP9 complex is composed by eight subunits and is also called signalosome, because of its involvement in various signal transduction pathways.; Function: mutations in the FUS6 gene of A. thaliana cause severe developmental phenotypes, probably due to impairment of several signal transduction pathways.; Localization: FUS6 of A. thaliana is coimmunoprecipitated with the COP9 subunit of the COP9 complex, and both are located within the nucleus.; Remark: FUS6 of A. thaliana is also known as COP11.; Similarity: the COP9 complex is related to the 26S proteasome regulatory complex.; Similarity: the protein contains a homology domain of unclear function, called PCI or PINT motif; apparently,all of the characterized proteins containing PCI domains are parts of larger multi-protein complexes.; Title: strong similarity to FUSCA protein FUS6 -Arabidopsis thaliana; nucleus; See PMID 8130643; See PMID 8689678; See PMID 8953769; See PMID 9707402
An16g07950	Similarity: automatically detected similarities are due to repetitive amino acid stretches.
An16g07960	Title: similarity to hypothetical transporter protein AAM72702.1 - Chlorobium tepidum
An16g07970	Similarity: the protein shows a strong similarity to a genomic clone of A. thaliana whit unknown function.; Similarity: the similarity with Amfr of M. musculus is mainly due to the C3HC4 type zinc finger (RING finger).; Title: similarity to autocrine motility factor receptor Amfr - Mus musculus; See PMID 10456327
An16g07980	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger
An16g07990	Similarity: the weak similarity to CG13953 of D. melanogaster refers only to the N-terminus and is partially due to repetitive amino acid stretches.; Title: weak similarity to hypothetical protein encoded by CG13953 - Drosophila melanogaster
An16g08000	Complex: Rpp1 of S. cerevisiae also appear to be shared between RNase P and RNase MRP.; Complex: the RNaseP complex of S. cerevisiae,besides Rpp1, contains at least these further components: Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, and Rpr2.; Function: Rpp1 of S. cerevisiae is an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA.; Localization: Rpp1 is located in the nucleus of S. cerevisiae.; Phenotype: depletion of Rpp1 in vivo leads to the accumulation of precursor tRNAs with unprocessed 5' and 3' termini and defects in rRNA maturation in S. cerevisiae.; Similarity: hypothetical protein YHR062c of S. cerevisiae is identical to Rpp1 (GENBANK Acc. AAB68389).; Title: strong similarity to protein subunit of nuclear RNaseP Rpp1 - Saccharomyces cerevisiae; nucleus; See PMID 9308968; See PMID 9620854
An16g08010	Function: Casein kinase II is thought to play an essential role in the control of cell division and differentiation in all eukaryotes.; Title: strong similarity to Casein kinase CK II -Arabidopsis thaliana; See PMID 7678767; See PMID 8061317
An16g08020	Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).; Function: cyt-20 of N. crassa encodes both the cytosolic and mitochondrial valine--tRNA ligase.; Title: strong similarity to valine--tRNA ligase cyt-20 - Neurospora crassa [putative frameshift]; putative frameshift
An16g08030	Similarity: patentmatch against ovarian tissue derived protein 18 Y59741 Patentprot.; Title: strong similarity to ovarian tissue derived protein 18 from patent DE19816395-A1 - Homo sapiens
An16g08040	Title: strong similarity to hypothetical protein PMP24 - Mus musculus
An16g08050	Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa
An16g08060	Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O; Function: the P450rm protein of R. minuta is involved in the dissimilation pathway starting from L-phenylalanine.; Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: Phenylalanine metabolism; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702
An16g08070	Similarity: patentmatch against fumonisin esterase R91277 Patentprot.; Title: strong similarity to fumonisin esterase from patent WO9606175-A2 - Exophiala spinifera
An16g08080	Similarity: patentmatch against transport protein AX066343_1 TremblNew.; Similarity: similarties to pro- and eukaryotic mutidrug-efflux transporters.; Title: strong similarity to transporter from patent WO0100804 - Corynebacterium glutamicum
An16g08090	Title: strong similarity to hypothetical protein B2J23.120 - Neurospora crassa
An16g08100	Catalytic activity: (-)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2).; Title: similarity to hypothetical ureidoglycolate hydrolase SPAC19G12.04 - Schizosaccharomyces pombe
An16g08110	Function: the S. cerevisiae MSH 1 protein is involved in mitochondrial DNA repair; it belongs to the DNA mismatch repair mutS family.; Title: strong similarity to protein Msh1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1334021; See PMID 1459447
An16g08120	Function: S. cerevisiae Brr2p protein promotes RNA rearrangements, acting synergistically with other spliceosomal proteins, including the structurally related Prp2p and Prp16p.; Remark: 3'-truncated ORF due to end of contig.; Similarity: similarities in C-terminus extend over contig border.; Title: strong similarity to pre-mRNA splicing helicase Brr2 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 11290703
An16g08130	Similarity: AmdX of A. nidulans belongs to the nuclear hormone receptors family.; Title: similarity to DNA binding regulatory protein amdX - Aspergillus nidulans; nucleus; See PMID 9044292
An16g08140	Catalytic activity: salcylate hydroxylases catalyze the reaction of salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2.; Function: salicylate hydroxylase of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Pathway: salcylate hydroxylases belong to the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Remark: nahg and salicylate 1-monooxygenase are alternative names for salicylate hydroxylase of P. putida.; Title: similarity to salicylate hydroxylase sal -Pseudomonas putida; See PMID 10920265; See PMID 8695632
An16g08150	Catalytic activity: DPP V of A. fumigatus hydrolyses X-Ala, His-Ser, and Ser-Tyr dipeptides at a neutral pH optimum.; Localization: DPP V of A. fumigatus is a secreted protein.; Title: strong similarity to dipeptidyl-peptidase V DPP V - Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9045640
An16g08160	Title: similarity to hypothetical protein B16B8.310 - Neurospora crassa
An16g08170	Phenotype: Gain-of-function mutations of HOL1 confer non-selective cation transport.; Phenotype: the HOL1 null mutant unable to uptake histidinol or Na+.; Remark: YNR055C is the systematic name for HOL1.; Similarity: HOL1 is a member of major facilitator superfamily multidrug-resistance protein subfamily 1.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2405251; See PMID 8955402
An16g08180	Catalytic activity: PKL12 of M. musculus catalyzes the reaction of ATP + a protein = ADP + a phosphoprotein.; Function: PKL12 of M. musculus is a protein kinase that acts on both serine and threonine residues.; Remark: myristoylated and palmitoylated serine-threonine kinase, TGF-beta stimulated factor 1,TSF-1, serine/threonine protein kinase 16, STK16, MPSK1,TSF1, EDPK and KRCT are alternative names for PKL12.; Remark: putative sequencing error at position 14768 one base pair too much.; Similarity: PKL12 of M. musculus belongs to the ser/thr family of protein kinases.; Title: similarity to palmitylated serine/threonine kinase PKL12 - Mus musculus [putative frameshift]; deleted EC_number 2.7.1.37; putative frameshift; See PMID 9712705
An16g08200	Function: dynactin is a major component of activator I, a 20s polypeptide complex that stimulates dynein-mediated vesicle transport.; Title: similarity to dynactin Chip150 - Gallus gallus; See PMID 1836789
An16g08210	Catalytic activity: BNA1 of S. cerevisiae catalyzes the reaction of 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.; Pathway: BNA1 of S. cerevisiae is involved in nicotinic acid biosynthesis.; Remark: 3-hydroxyanthranilic acid dioxygenase,3-hydroxyanthranilate oxygenase HAD1, YJR025C, J1550 and 3-HAO are alternative names for BNA1 of S. cerevisiae.; Title: strong similarity to 3-hydroxyanthranilic acid dioxygenase Bna1 - Saccharomyces cerevisiae; See PMID 9539135
An16g08220	Complex: associates with u3 snoRNP, but is not its structural component.; Function: RCL1 of S. cerevisiae does not have cyclase activity.; Function: RCL1 of S. cerevisiae plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites a0, a1 and a2, that are required for proper maturation of the 18S RNA.; Localization: nuclear; nucleolus.; Remark: RTC1 and YOL010W are alternative names for RCL1 of S. cerevisiae.; Remark: putative sequencing error at position 20385,one base pair too much.; Similarity: belongs to the RNA 3'-terminal cyclase family subfamily 2.; Title: similarity to RNA 3-phosphate cyclase-like protein Rcl1 - Saccharomyces cerevisiae [putative frameshift]; nucleus; putative frameshift
An16g08250	Remark: blastp matches are only due to repetitive amino acids.
An16g08330	Catalytic activity: mae1 protein of S. pombe is catalyses C4-dicarboxylate (out) + nH+ (out) ---> C4-dicarboxylate (in) + nH+ (in).; Function: mae1 of S. pombe is involved in the uptake of L-malate, succinate and malonic acid by a proton symport mechanism.; Remark: mae1 of S. pomble belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 10082980
An16g08360	Remark: N-terminally truncated ORF due to contig border.; Remark: no similarities of the predicted ORF to the highly conserved signal sequence or cell wall attachment region of the best blast match, the collagen-like surface protein SclA from S. pyogenes were found.; Title: weak similarity to cytochrome c1 of ubiquinol--cytochrome-c reductase - Paracoccus denitrificans [truncated ORF]
An16g08370	Function: Jac1 of S. cerevisiae, together with the Ssq1 70KDa chaperone protein, is essential for the formation of the Fe/S clusters of different proteins and for mitochondrial iron metabolism.; Localization: Jac1 of S. cerevisiae is located in the mitochondrial matrix.; Remark: Jac1 of S. cerevisiae is also known as YGL018C.; Similarity: Jac1 of S. cerevisiae belongs to the the 20-kDa J-protein family of co-chaperones; the name derives from the DnaJ protein of E. coli.; Title: similarity to mitochondrial J-type chaperone Jac1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9813017; See PMID 11171977; See PMID 11273703
An16g08380	Complex: PRP4 of S. cerevisiae is a protein of the U4/U6 small nuclear ribonucleoprotein particle (snRNP),required early in the spliceosome assembly pathway.; Function: as an essential component of the spliceosome, PRP4 of S. cerevisiae participate in the process of pre-mRNA splicing.; Phenotype: null mutation of PRP4 in S. cerevisiae is lethal.; Remark: PRP4 of S. cerevisiae is also called RNA4 or YPR178W.; Similarity: homologues of PRP4 were found in many different species, comprising A. thaliana and humans.; Title: strong similarity to U4/U6 snRNP 52kD protein Prp4 - Saccharomyces cerevisiae; nucleus; See PMID 10900456; See PMID 2528687; See PMID 3536128; See PMID 8202378
An16g08390	Function: althoug the functions of S. pombe AZR1 are not fully understood, the gene may be involved in resistance to 5-azacytidine.; Similarity: another region of the predicted ORF shows strong similarity to the AZR1 protein of S. pombe.; Similarity: the similarity to the A. pullulans ORF is limited to the C-terminal half of the protein.; Title: similarity to sequence 4 from patent WO0063399 - Aureobasidium pullulans
An16g08400	Similarity: the 35 N-terminal amino acids of the predicted ORF show similarity to the D. melanogaster CG15759 gene with unknown function.
An16g08410	Localization: in vertebrates neurofilaments are components of the cytoskeleton within neural cell cytoplasmic extensions.; Similarity: the predicted ORF contains a PWWP domain, named after a conserved Pro-Trp-Trp-Pro motif, whose function is currently unknown.; Similarity: the predicted ORF shows a stronger similarity to a S. pombe hypothetical protein.; Similarity: the similarity to NF-180 of P. marinus and other neurofilament proteins is mainly due to low complexity regions.; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; cytoskeleton; See PMID 7770000
An16g08420	Similarity: shows strong similarity to a 5'-EST of the A. niger cDNA clone an_3071.; Title: similarity to hypothetical integral membrane protein SC10B7.28 - Streptomyces coelicolor
An16g08440	Title: similarity to hypothetical protein T6K22.50 -Arabidopsis thaliana
An16g08450	Similarity: contains a fungal-type DNA-binding Zn(2)-Cys(6) binuclear cluster domain.; Title: strong similarity to hypothetical transcriptional regulator SPCC417.09c - Schizosaccharomyces pombe
An16g08460	Function: Sla1p of S. cerevisiae is essential for the proper formation of the cortical actin cytoskeleton.; Function: Sla1p of S. cerevisiae is involved in cellular morphogenesis and polarization of the cortical cytoskeleton.; Similarity: the N-terminus contains three SH3 domains similar to those found in signal transduction proteins that function at the membrane/cytoskeleton interface.; Title: strong similarity to cytoskeleton assembly control protein Sla1 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8335689
An16g08470	Function: OS-9 of H. sapiens is coamplified with the CDK4 gene in human sarcomas.; Title: similarity to hypothetical cell growth regulator OS-9 - Homo sapiens; See PMID 9562620
An16g08480	Function: pirin of H. sapiens interacts with the nuclear factor I/CCAAT box transcription factor (NFI/CTF1),which stimulates RNA polymerase II-driven transcription.; Localization: pirin of H. sapiens was found to be localized within dot-like subnuclear structures.; Title: strong similarity to cofactor of NFI/CTF1 transcription activator pirin - Homo sapiens; nucleus; See PMID 9079676
An16g08490	Function: PMT4 of S. cerevisiae transfers a mannosyl residue from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins.; Pathway: PMT4 of S. cerevisiae is involved in the O-glycosylation of proteins in the endoplasmatic reticulum.; Title: strong similarity to dolichyl-phosphate-D-mannose--protein O-mannosyltransferase Pmt4 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8585318
An16g08500	Title: weak similarity to hypothetical protein CG1703 - Drosophila melanogaster
An16g08510	Function: Tna1p of S. cerevisiae is involved in the uptake of nicotinic acid.; Remark: the systematic gene name of TNA1 of S. cerevisiae is YGR260w.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An16g08520	Function: Pth11p of M. grisea functions at the cell cortex as an upstream effector of appressorium differentiation in response to host surface recognition.; Pathway: Pth11p of M. grisea is involved in pathogenicity signaling.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An16g08530	Function: omtB of A. parasiticus converts demethylsterigmatocystin to sterigmatocystin.; Pathway: omtB of A. parasiticus is involved in the aflatoxin biosynthesis pathway.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361
An16g08540	Complex: cytoplasmic dynein is a multisubunit complex consisting of several small, intermediate and large subunits.; Function: cytoplasmic dynein is a microtubule-based motor protein, which mediates movement of numerous intracellular organelles.; Title: strong similarity to cytoplasmic dynein intermediate chain 1 DNCI1 - Homo sapiens; cytoskeleton; See PMID 10049579
An16g08550	Complex: Tim11p of S. cerevisiae is part of the F0 complex of the proton-transporting mitochondrial ATP synthase.; Function: Tim11p of S. cerevisiae is essential for ATP synthase dimerization, which is thought to enhance the stability and efficiency of ATP synthase complexes.; Localization: F0 of ATP synthase is located in the inner mitochondrial membrane.; Remark: the systematic name of TIM11 of S. cerevisiae is YDR322c-a.; Similarity: matches several A. niger ESTs including the patent database entry PATENTDNA:AAF11558.; Title: strong similarity to ATP synthase coupling factor (F0) subunit e Tim11 - Saccharomyces cerevisiae; See PMID 9271204; See PMID 9857174
An16g08560	Function: COP9 of A. thaliana is involved in the control of a light-mediated developmental switch.; Similarity: COP9 of H. sapiens is homologous to COP9 of A. thaliana.; Similarity: shows homology to a protein of patent database entry PATENTPROT:AAW68581.; Title: similarity to COP9 protein homolog from patent US5831059-A - Homo sapiens
An16g08570	Complex: STT3 of S. cerevisiae is thought to participate in the OTase complex in substechiometric amounts or to be required for OTase assembly.; Function: stt3 of S. pombe is essential for OTase activity.; Localization: STT3 of S. cerevisiae is an integral membrane protein of the endoplasmatic reticulum.; Pathway: OTase of S. pombe facilitates the transfer of the core oligonucleotide from dolichyl-PP to Asn-protein (N-linked glycosylation).; Similarity: stt3 of S. pombe is homologous to STT3 of S. cerevisiae.; Title: strong similarity to translation initiation factor 3 47 kDa subunit stt3p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 10234787; See PMID 7588624
An16g08580	Similarity: shows homology to an EST of patent database entry PATENTDNA:AAF13645.; Title: similarity to EST SEQ ID NO:6168 from patent WO200056762-A2 - Aspergillus oryzae
An16g08610	Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin.; Pathway: TRI101 of F. sporotrichioides acts in the trichothecene biosynthesis pathway as well as in self-protection from the trichothecene toxins.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973
An16g08620	Function: PTA1 of S. cerevisiae is involved in pre-tRNA splicing.; Title: strong similarity to pre-tRNA processing protein Pta1 - Saccharomyces cerevisiae; See PMID 1508188
An16g08630	Function: Dep1p of S. cerevisiae is involved in the regulation of the expression of the phospholipid biosynthesis structural genes INO1, CHO1 and OPI3 in response to soluble lipid precursors.; Phenotype: dep1 mutants of S. cerevisiae display pleiotropic deficiencies in transcriptional activation and repression.; Title: similarity to regulator of phospholipid metabolism Dep1 - Saccharomyces cerevisiae; See PMID 8056324
An16g08640	Function: motif similarities suggest involvment in RNA processing activities.; Title: strong similarity to hypothetical RNA-binding protein SPAC16E8.06c - Schizosaccharomyces pombe
An16g08650	Remark: a splice site was detected upstream of the START codon.
An16g08670	Similarity: also shows similarity to an A. oryzae EST from patent WO200056762-A2 (PATENTDNA:AAF13997).; Title: strong similarity to hypothetical protein AAL92654.1 - Dictyostelium discoideum
An16g08680	Title: similarity to hypothetical protein CC3654 -Caulobacter crescentus
An16g08700	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to cylicin II - Bos taurus
An16g08710	Complex: S. cerevisiae Rpc25 is one of about 15 different subunits of the RNA polymerase III.; Remark: S. cerevisiae Rpc25 (C25), like Rpb7 (RNA PolII), is present in submolar ratios, easily dissociates from the enzyme, is essential for cell growth and viability, but is not required in certain transcription assays in vitro.; Remark: alternate names for S. cerevisiae Rpc25: YKL144c, C25, YKL1.; Similarity: S. cerevisiae Rpc25 is related to the S. cerevisiae RNA polymerase II subunit, Rpb7.; Title: strong similarity to 25 kD subunit of DNA-directed RNA Polymerase III Rpc25 - Saccharomyces cerevisiae; nucleus; See PMID 8065349
An16g08720	Catalytic activity: L-cystathionine + H(2)O <=> L-cysteine + NH(3) + 2-oxobutanoate.; Cofactor: Pyridoxal-phosphate.; Pathway: the cystathionine gamma-lyase MecB from A. chrysogenum is involved in cysteine metabolism.; Title: strong similarity to cystathionine-gamma-lyase mecB - Acremonium chrysogenum; See PMID 11254121
An16g08730	Similarity: the ORF encoded protein shows also significant similarity to the Arabidopsis thaliana protein fragment SEQ ID NO: 49688 from patent EP1033405-A2, but its function is not decribed.; Title: strong similarity to hypothetical protein YIL110w - Saccharomyces cerevisiae
An16g08740	Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Complex: N. crassa Nuo-17. 8 is part of the complex I of the respiratory chain. Complex I is composed of about 40 different subunits.; Function: Complex I is responsible for the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is ubiquinone.; Remark: the EC number from the database entry was corrected to EC 1. 6. 5. 3, as it is a component of the mitochondrial respiratory chain (transfer of electrons to ubiquinone).; Title: strong similarity to 17.8 kD subunit of NADH:ubiquinone reductase Nuo-17.8 - Neurospora crassa; localisation:mitochondrion; See PMID 8343129
An16g08760	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: similarity to zinc metalloprotease ZmpB from patent WO9964610-A1 - Streptococcus pneumoniae
An16g08770	Title: weak similarity to hypothetical protein At2g40070 - Arabidopsis thaliana
An16g08780	Similarity: the ORF encoded protein shows significant domain similarity to many zinc finger and putative zinc finger transcription factors.; Title: similarity to zinc-finger transcription factor Cre1 - Trichoderma harzianum; nucleus; See PMID 8709949
An16g08800	Remark: Trichoderma reesei=Hypocrea jecorina.; Similarity: the ORF encoded protein shows significant domain similarity to many zinc finger and putative zinc finger transcription factors.; Title: similarity to zinc-finger transcription factor AceI - Trichoderma reesei; nucleus; See PMID 10681571
An16g08810	Title: weak similarity to hypothetical membrane protein YPL099c - Saccharomyces cerevisiae
An16g08820	Remark: alternate name for S. cerevisiae Yta7: YGR270w.; Similarity: S. cerevisiae Yta7 belongs to the AAA family of ATPases.; Title: strong similarity to hypothetical AAA-type ATPase Yta7 - Saccharomyces cerevisiae
An16g08830	Complex: Sec71 from S. cerevisiae forms a complex together with Sec61, Sec62, Sec63, Sec72, and Kar2.; Function: Sec71 from S. cerevisiae interacts with the signal peptide of a secretory precursor and transfers it to the translocation pore.; Function: Sec71 from S. cerevisiae is essential for growth at elevated temperatures.; Function: Sec71 from S. cerevisiae is required to attach or retain Sec72 in the Sec63 complex.; Function: Sec71 from S. cerevisiae plays a direct role in the translocation of some presecretory proteins into the endoplasmic reticulum.; Remark: synonyms for Sec71 from S. cerevisiae are Sec66, Hss1 and YBR171w.; Title: strong similarity to component of ER protein-translocation subcomplex Sec71 from patent WO9949028-A1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8253836; See PMID 8257794; See PMID 8257795
An16g08840	Title: strong similarity to hypothetical protein CAE76483.1 - Neurospora crassa
An16g08850	Complex: p81 from X. laevis is a component of the Xenopus origin recognition complex.; Phenotype: Immunodepletion of p81 from Xenopus egg extracts completely abolishes chromosomal DNA replication.; Title: strong similarity to origin recognition complex associated protein p81 - Xenopus laevis; nucleus; See PMID 9733795
An16g08860	Phenotype: S. cerevisiae spores harbouring disruptions in Nop14 germinated but underwent only a few divisions before ceasing growth, suggesting that Nop14 is essential for vegetative growth.; Remark: the synonym for Nop14 from S. cerevisiae is YDL148c.; Title: strong similarity to nuclear and nucleolar protein Nop14 - Saccharomyces cerevisiae; nucleus; See PMID 10487930
An16g08870	Catalytic activity: Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Remark: Galactomyces geotrichum = Geotrichum candidum.; Remark: lipI from G. candidum belongs to the hydrolases acting on ester bonds.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; See PMID 2340308; See PMID 7737187
An16g08880	Similarity: the similarities to lower scored matches are based on repetetive structures.; Title: similarity to hypothetical protein T04H1.5 -Caenorhabditis elegans
An16g08890	Function: Hydroxyproline-rich glycoproteins are the predominant components of the cell wall of the green alga Chlamydomonas reinhardtii.; Similarity: the similarities are based on repetetive structures.; Title: similarity to gamete-specific hydroxyproline-rich glycoprotein A2 - Chlamydomonas reinhardtii; See PMID 11258910
An16g08900	Title: weak similarity to atrophin-1 related protein from patent WO9921983-A1 - Homo sapiens
An16g08910	Function: Srp40 from S. cerevisiae genetically interacts with four mutants affected in stable RNA synthesis and one mutant blocked in protein translocation to the endoplasmic reticulum.; Function: Srp40 from S. cerevisiae is phosphorylated by casein kinase II.; Localization: Srp40 from S. cerevisiae localizes in the nucleolus.; Phenotype: Growth defects, but no translocation or rRNA transcription/maturation phenotypes, were observed upon inactivation or strong overexpression ofSrp40 from S. cerevisiae .; Remark: the systematic name for Srp40 from S. cerevisiae is YKR092C.; Similarity: the similarities are based on repetetive structures.; Title: similarity to nucleolar protein Srp40 -Saccharomyces cerevisiae; See PMID 8702624; See PMID 9364927
An16g08920	Remark: strong evidence for a role of neurofilament phosphorylation in the establishment of neurofilament density and axonal caliber.; Remark: synonyms for NEFH from H. sapiens are NF-H,neurofilament triplet H protein and neurofilament protein.; Remark: the human NEFH subunit can get phosphorylated in axons.; Similarity: the human NEFH contains a KSP motif,named after a conserved Lys-Ser-Pro phosphorylation motif.; Title: similarity to neurofilament triplet H protein NEFH - Homo sapiens; cytoskeleton; See PMID 3138108
An16g08940	Remark: a splice site was detected upstream of the START codon.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on mRNA obtained from A. thaliana.; Title: strong similarity to protein fragment SEQ ID NO:26152 from patent EP1033405-A2 - Arabidopsis thaliana
An16g08950	Remark: plays a crucial role in the association of the barbed ends of actin filaments with the plasma membrane in the cell-to-cell adherens junction and the cleavage furrow.; Title: similarity to radixin - Mus musculus; See PMID 195545; See PMID 1429901
An16g08980	Remark: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: strong similarity to cutinase transcription factor beta CTF1b - Fusarium solani; See PMID 9139694
An16g09010	Remark: a putative sequencing error results in a frameshift.; Title: strong similarity to carboxypeptidase I protein from patent WO9814599-A1 - Aspergillus oryzae [putative frameshift]; putative frameshift; See PMID 8224168
An16g09020	Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe
An16g09040	Catalytic activity: N-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate.; Pathway: N-acetyl glucosamine utilization.; Title: strong similarity to N-acetylglucosamine-6-phosphate deacetylase CaNAG2 -Candida albicans; See PMID 11298769
An16g09050	Catalytic activity: alcohol + acceptor = aldehyde + reduced acceptor.; Cofactor: FAD.; Function: converts aliphatic medium-chain-length alcohols into aldehydes.; Remark: belongs to the GMC oxidoreductases family.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas oleovorans; See PMID 1453953
An16g09060	Catalytic activity: betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.; Complex: homotetramer.; Function: enzyme catalyzes the last step in the biosynthesis of betaine.; Pathway: betaine biosynthesis.; Remark: betaine is a protective osmolyte induced to accumulate by osmotic stress.; Title: strong similarity to betaine-aldehyde dehydrogenase betB - Escherichia coli
An16g09070	Catalytic activity: D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).; Complex: homohexamer.; Function: Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia.; Induction: N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.; Pathway: N-acetyl glucosamine utilization.; Remark: EC 5. 3. 1. 10 was transferred to EC 3. 5. 99. 6; Title: strong similarity to glucosamine-6-phosphate deaminase from patent WO9835047-A1 - Escherichia coli; See PMID 2190615; See PMID 3284790; See PMID 8747459; See PMID 10378272; See PMID 1734962
An16g09090	Title: strong similarity to beta-N-acetylglucosaminidase nagA - Streptomyces thermoviolaceus; See PMID 9687451
An16g09100	Title: strong similarity to EST SEQ ID NO:4175 from patent WO200056762-A2 - Aspergillus niger
An16g09130	Function: the acid phosphatase activity encoded by the A. nidulans gene was demonstrated by cytochemistry.; Similarity: the predicted ORF is much more similar to Penicillium chrysogenum PHOG, that is a putative acid phosphatase based on the similarity to the A. nidulans gene.; Title: strong similarity to 35.6K acid phosphatase -Aspergillus nidulans; See PMID 7628710; See PMID 7916713
An16g09140	Complex: CFT1 of S. cerevisiae is a subunit of the cleavage factor II (CFII), a complex required for cleavage of the 3' end of pre-mRNA before polyadenylation.; Function: in mammals CPSF-160 is precisely involved in the recognition of the AAUAAA signal sequence for polyadenilation.; Remark: CFT1 of S. cerevisiae is also known as YHH1 or YDR301W.; Similarity: CFT1 of S. cerevisiae and the predicted protein are similar to the 160kDa subunit of mammalian cleavage and polyadenilation specificity factor CPSF-160.; Title: strong similarity to pre-mRNA 3-end processing factor CF II Cft1 - Saccharomyces cerevisiae; nucleus; See PMID 8929410; See PMID 9099738; See PMID 9303317; See PMID 10523662
An16g09150	Similarity: the predicted ORF shows strong similarity to some conceptual translations of human cDNAs; BM-021 was cloned from bone marrow RNA preparations.; Title: strong similarity to hypothetical protein BM-021 - Homo sapiens
An16g09160	Similarity: another A. niger EST, namely EMBLEST:BE760254, confirms the expression of the predicted ORF.; Title: strong similarity to EST AN05D03 -Aspergillus niger
An16g09180	Remark: There are two systems for zinc uptake in S. cerevisiae, one high-affinity and one lower-affinity.; Remark: ZRT2 of S. cerevisiae is also called YLR130C.; Similarity: ZRT2 and the high-affinity zinc transporter ZRT1 of S. cerevisiae are similar to each other, and are members of the ZIP family of heavy metal ion transporters.; Title: strong similarity to low affinity zinc transport protein Zrt2 - Saccharomyces cerevisiae; See PMID 8798516; See PMID 9271382; See PMID 9784581; See PMID 10748254; See PMID 10856230
An16g09190	Catalytic activity: ERG10 of S. cerevisiae encodes acetyl-CoA C-acetyltransferase (also called acetoacetyl-CoA thiolase), a cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA.; Pathway: the formation of acetoacetyl-CoA is the first step in the biosynthesis of mevalonate, which is required in turn for the biosynthesis of sterols and nonsterol isoprenoids.; Title: strong similarity to cytosolic acetyl-CoA C-acetyltransferase Erg10 - Saccharomyces cerevisiae; cytoplasm; See PMID 2900076; See PMID 7989303; See PMID 8754796
An16g09200	Similarity: although many of the BLASTP homologues to the predicted protein are annotated as translation elongation factor 2, this functional description is questionable, as it is normally based on sequence similarity.; Similarity: the best experimentally studied homologue is M. musculus U5-116kD, which indeed shows strong similarity to elongation factor 2, but is involved in pre-mRNA splicing and localizes in the nucleus, instead of being involved in protein synthesis and being located in the cytoplasm.; Title: strong similarity to U5 snRNP-specific protein U5-116kD - Mus musculus; nucleus; See PMID 9233818
An16g09210	Phenotype: null mutation of YHR122w in S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein YHR122w - Saccharomyces cerevisiae
An16g09220	Title: questionable ORF
An16g09230	Function: the N. crassa nit-4 protein pathway-specific regulatory gene of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: in the predicted protein the fungal Zn(2)-Cys(6) binuclear cluster motif is not very conserved.; Similarity: the nit-4 protein from N. crassa is a fungal Zn(2)-Cys(6) binuclear type transcription factor.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; See PMID 1840634; See PMID 7592372
An16g09250	Function: RRF of T. thermophilus and other bacteria is required for decomposition of the post-termination complex of the ribosome after release of polypeptides.; Similarity: many eukaryotic proteins showing significant similarity to bacterial RRF were identified; some of them localize in subcellular compartments like mitochondria or chloroplasts; their function is still largely unclear.; Title: similarity to ribosome recycling factor RRF -Thermus thermophilus; See PMID 9258437; See PMID 10214965
An16g09260	Complex: SSB2 of S. cerevisiae binds to ribosomes and nascent polypeptide chains.; Function: SSB2 of S. cerevisiae may aid in the passage of the nascent polypeptide chain through the ribosome channel into the cytosol.; Similarity: SSB2 of S. cerevisiae is almost identical to SSB1 of the same organism, probably indicating overlapping functions.; Similarity: the predicted protein is almost identical to hscA of A. nidulans, a putative protein belonging to the heat shock protein 70 family.; Title: strong similarity to dnaK-type molecular chaperone Ssb2 - Saccharomyces cerevisiae; cytoplasm; See PMID 1833403; See PMID 2651414; See PMID 8336673; See PMID 1394434; See PMID 1644272
An16g09270	Complex: CKS1 of S. cerevisiae is a protein that associates with the cyclin-dependent kinase CDC28 and is involved in cell cycle control.; Function: phosphorylation of SIC1 by G1-Cdk complexes is required for SIC1 degradation and entry into S phase.; Similarity: the ORF was modeled according to A. niger EST SEQ ID NO:3874 of patent WO200056762-A2, which comprises all the exons and the 5'- and 3'-UTRs.; Title: strong similarity to cyclin-dependent kinase regulatory subunit Cks1 - Saccharomyces cerevisiae; See PMID 2227411; See PMID 2664468; See PMID 2699737; See PMID 7958905; See PMID 8491379
An16g09280	Title: weak similarity to hypothetical protein AAF79893.1 - Arabidopsis thaliana
An16g09300	Similarity: the similarity to A. thaliana ReMembR-H2 and other proteins is due to the presence of a RING-finger motif, that is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions.; Title: weak similarity to RING finger protein ReMembR-H2 - Arabidopsis thaliana; See PMID 10953001
An16g09310	Catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: PPIASEs accelerate the folding of proteins.; Regulation: PPIASEs bind Cyclosporin A (CsA); CsA mediates some of its effects via an inhibitory action on PPIASEs.; Similarity: the predicted protein shows strong similarity to several hypothetical and known peptidyl-prolyl cis-trans isomerase (PPIASEs), which bind cyclosporin A, and are therefore also called cyclophilins.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase CYP - Lycopersicon esculentum; See PMID 1702215
An16g09320	Function: ALA1 of S. cerevisiae converts ATP + L-alanine + tRNA(ALA) to AMP + pyrophosphate + L-alanyl-tRNA(ALA).; Similarity: the gene model is confirmed by several A. niger ESTs.; Title: strong similarity to cytosolic alanine--tRNA ligase Ala1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7761427; See PMID 8896263; See PMID 10601222
An16g09330	Similarity: this gene also shows weak similarity to EST an_3407 from Aspergillus niger; Title: weak similarity to hypothetical protein B5K2.180 - Neurospora crassa
An17g00010	Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) <=> RCHO + NH(3) + H(2)O(2).; Induction: AMO of H. polymorpha is induced when primary amines are the sole nitrogen source.; Localization: AMO of H. polymorpha is located in the peroxisomal matrix.; Remark: AMO of H. polymorpha requires copper as a cofactor.; Title: strong similarity to amine oxidase AMO -Hansenula polymorpha; See PMID 2500147; See PMID 8511963
An17g00030	Function: RAD5 of S. cerevisiae is non-essential and functions in error-free postreplication repair where it is involved in the avoidance of non-homologous end-joining of DNA double strand breaks.; Remark: RAD5 of S. cerevisiae is also known as REV2,SNM2 and YLR032W.; Title: weak similarity to DNA repair protein Rad5 -Saccharomyces cerevisiae; See PMID 9016623; See PMID 1324406; See PMID 1394508
An17g00070	Remark: the predicted ORF contains a relatively long intron.
An17g00090	Title: weak similarity to translocation protein Sec72 - Saccharomyces cerevisiae
An17g00100	Function: the transposase in the A. niger Tan1 transposable element excises the Vader element within Tan1.; Similarity: the transposase in the A. niger Tan1 transposable element shows similarity to the F. oxysporum Fot1 and M. frisea Pot2 transposases.; Title: strong similarity to transposase of Tan1 -Aspergillus niger; putative frameshift; See PMID 9003286; See PMID 10547692
An17g00120	Function: msf1 of B. cinerea acts in the protection against fungicides and is involved in multi-drug resistance development.; Similarity: msf1 of B. cinerea is a member of the major facilitator superfamily.; Title: strong similarity to major facilitator superfamily transporter protein mfs1 - Botrytis cinerea; See PMID 10955904; See PMID 11374155
An17g00130	Function: cercosporin is a photosensitizing perylenequinone toxin and crg1 from C. nicotianae provides direct resistance to its activity.; Title: weak similarity to cercosporin resistance protein crg1 - Cercospora nictotianae; See PMID 10517336
An17g00140	Complex: lovastatin lovB is a heterodimer of a nonaketide chain and a diketide,2-methylbutyrate.; Function: lovastation lovB of A. terreus is an HMG-CoA reductase inhibitor whose nonaketide chain undergoes cyclization to a hexahydronaphthalene ring system.; Remark: the nonaketide and diketide chains are synthesized by separate large multifunctional polyketide synthases.; Similarity: An17g00140 shows similarity only to a middle section of the long (3038 amino acids) lovB sequence from A. terreus.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [putative frameshift]; putative frameshift; See PMID 10381407; See PMID 11378962
An17g00150	Similarity: the ORF encoded protein has similarity only to the C-terminal region of M. grisea gag protein encoded within a transposon.; Title: weak similarity to protein gag - Magnaporthe grisea
An17g00160	Remark: the ORF has a short length (98 amino acids).
An17g00200	Catalytic activity: S-adenosyl-L-methionine + catechol <=> S-adenosyl-L-homocysteine + guaiacol.; Complex: rat COMT exists as a monomer.; Function: catechol O-methyltransferase (COMT) has a role in the inactivation of catecholamine neurotransmitters.; Localization: in rat two forms of COMT exist, a soluble form (S-COMT) which is cytoplasmic and a membrane-bound form (MB-COMT).; Remark: in rat S-COMT and MB-COMT are encoded by the same gene but use two different promoters, P1 which is regulated in a tissue-specific manner and P2 which functions constitutively.; Title: strong similarity to catechol O-methyltransferase - Rattus norvegicus; See PMID 8672242; See PMID 9262345; See PMID 2227437; See PMID 2645868; See PMID 8280056
An17g00210	Remark: strong similarity to A. niger EST sequence BE759508 in EMBLEST.; Similarity: strong similarity to many hypothetical oxidoreductases predicted in many different species.; Title: strong similarity to hypothetical oxidoreductase CAB46711.1 - Schizosaccharomyces pombe
An17g00230	Title: similarity to hypothetical protein slr0789 -Synechocystis sp.
An17g00240	Remark: An17g00240 shows strong similarity to many A. thaliana patent EST sequences.; Remark: YER036c of S. cerevisiae is also known as KRE30.; Similarity: strong similarity to many hypothetical ABC transporter proteins in many different species.; Title: strong similarity to hypothetical protein YER036c - Saccharomyces cerevisiae
An17g00250	Complex: CCL1 interacts with the RNA polymerase II carboxy-terminal domain kinase KIN28, so forming a component of the trancription factor TFIIH.; Function: the CCL1/KIN28 complex is involved in regulating transcription by controlling the phosphorylation of RNA polymerase II.; Remark: CCL1 from yeast is also known as YPR025C.; Remark: CCL1/KIN28 from yeast are essential for cell proliferation.; Title: similarity to cyclin Ccl1 - Saccharomyces cerevisiae; See PMID 8557668; See PMID 8761664; See PMID 10594013; See PMID 8230216
An17g00260	Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.; Function: UBC1 catalyzes the covalent attachment of ubiquitin to proteins primarily involved in the early stages of growth after spore germination.; Pathway: UBC1 is a component of the protein degradation pathway.; Similarity: the ORF shows strong similarity to an A. thaliana patent protein sequence AAG04759.; Title: strong similarity to ubiquitin conjugating enzyme Ubc1 - Saccharomyces cerevisiae; See PMID 940954; See PMID 1740189; See PMID 1844315; See PMID 2265617; See PMID 2561543
An17g00270	Complex: the S4 chain is a component of the 26S protease multiprotein complex.; Function: 26S protease is involved in the ATP-dependent degradation of poly-ubiquinated proteins.; Remark: 26S protease has been shown, in fission yeast, to be essential for the completion of mitosis.; Similarity: the ORF shows strong similarity to human S4 protein patent sequence and to many A. thaliana patent sequences.; Title: strong similarity to 26S ATP/ubiquitin-dependent proteinase chain S4 -Schizosaccharomyces pombe; See PMID 8247131
An17g00280	Title: strong similarity to GTPase associated protein-13 GTPAP-13 from patent WO200031263-A2 - Homo sapiens
An17g00290	Remark: the human homolog is significantly shorter and shows only similarity to the N-terminal half of the protein bearing a number of putative transmembrane domains.; Title: strong similarity to hypothetical protein BAB14779.1 - Homo sapiens
An17g00300	Function: the T. ethanolicus homolog xarB encodes a bifunctional xylosidase-arabinosidase with activity against multiple substrates with the highest affinity towards p-nitrophenyl beta-D-xylopyranoside (pNPX) and highest activity against p-nitrophenyl alpha-L-arabinopyranoside (pNPAP), respectively.; Title: strong similarity to bifunctiona xylosidase-arabinosidase xarB - Thermoanaerobacter ethanolicus [putative frameshift]; putative frameshift
An17g00320	Title: strong similarity to hypothetical membrane protein YDR326c - Saccharomyces cerevisiae
An17g00330	Title: strong similarity to hypothetical protein related to ahmp1 - Neurospora crassa
An17g00340	Similarity: belongs to the fission yeast pyridoxine 4-dehydrogenase family.; Title: strong similarity to hypothetical oxidoreductase PA2535 - Pseudomonas aeruginosa
An17g00370	Similarity: shows strong similarity to expressed sequence tag seq id no:5420 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical single-stranded TG1-3 binding protein tcg -Schizosaccharomyces pombe
An17g00390	Title: strong similarity to aminopeptidase from patent WO9628542-A1 - Aspergillus oryzae
An17g00400	Function: the S. cerevisiae homolog GCS1 encodes an ADP-ribosylation factor GTPase-activating protein (ARF GAP) that is involved in regulating retrograde vesicular transport from the Golgi to the ER, as confirmed with in vitro vesicle transport assays.; Title: strong similarity to ARF GAP zinc finger protein Gcs1 - Saccharomyces cerevisiae; cytoplasm
An17g00410	Title: strong similarity to hypothetical protein EAA64027.1 - Aspergillus nidulans
An17g00420	Title: strong similarity to hypothetical protein YBR094w - Saccharomyces cerevisiae
An17g00430	Title: similarity to hypothetical protein EAA71271.1 - Gibberella zeae
An17g00440	Catalytic activity: cytochrome P-450 enzymes catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: avnA is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: A. parasiticus avnA encodes a fungal cytochrome P-450-type enzyme assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus
An17g00450	Catalytic activity: 2-trans,6-trans-farnesyl diphosphate <=> trichodiene + diphosphate.; Function: the F. poae homolog tri5 encodes a trichodiene synthase that participates in the biosynthesis of trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichodiene synthase tri5 from patent US6180366-B1 - Fusarium poae
An17g00470	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: pkaR is the regulatory subunit of the cAMP dependent protein kinase PKA, which has a broad influence on cell morphogenesis and cell development.; Title: strong similarity to cAMP dependent protein kinase regulatory subunit pkaR - Aspergillus niger; deleted EC_number 2.7.1.37
An17g00490	Function: the N. lactamdurans homolog AAR92153 is required for cephem hydroxylation at C-7 and the transfer of the methyl group from S-adenosylmethionine in the 7-hydroxycephem intermediate of the cephamycin biosynthetic pathway. acts as a coupling protein with the C-7 hydroxycephem methyltransferase (AAR92152).; Title: similarity to C-7 hydroxycephem methyltransferase coupling protein from patent WO9529253-A1 - Nocardia lactamdurans
An17g00520	Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidases have wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Similarity: belongs to the beta-glucosidases.; Title: strong similarity to beta-glucosidase precursor BGLUC - Kluyveromyces marxianus
An17g00530	Remark: the patent does not provide further information about the function of the protein.; Remark: the protein sequence of human beta-tubulin antigen is not complete.; Similarity: the predicted A. niger protein shows similarity to the protein sequence of human beta-tubulin antigen of patent WO200050593-A1 (AC# AAB08517), strong similarity to the hypothetical protein SPAC22F3. 14c of S. pombe and other hypothetical proteins from diverse eucaryotic species.; Title: similarity to beta-tubulin antigen from patent WO200050593-A1 - Homo sapiens
An17g00540	Function: S. cerevisiae Rlr1 is required for LacZ RNA expression from certain plasmids. It is suppressor of the transcriptional defect of Hpr1 by overexpression. It plays a role in transcription elongation by RNA polymerase II.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Rlr1: Tho2,YNL139C.; Title: similarity to suppressor of S.cerevisiae sin4 mutation Rlr1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10675628
An17g00550	Title: weak similarity to dTDP-glucose 4,6-dehydratase protein_id CAB05932.1 - Streptococcus pneumoniae
An17g00560	Complex: Biochemical cross-linking studies demonstrated that Vps5p and Vps17p physically interact.; Function: S. cerevisiae Vps17 is required for the sorting and delivery of a subset of soluble vacuolar hydrolases. It probably functions at an early stage of the sorting process. It is proposed that the Vps17 protein complex may participate in the intracellular trafficking ofthe Vps10-sorting receptor, as well as other later-Golgi proteins.; Remark: a splice site was detected upstream of the START codon.; Remark: alternate names for S. cerevisiae Vps17: YOR132W,Pep21.; Title: strong similarity to peripheral membrane protein required for vacuolar protein sorting Vps17 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9285823; See PMID 9700157; See PMID 8416961
An17g00570	Function: mitochondrial EF-G this catalyzes the gtp-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.; Localization: mitochondrium.; Title: strong similarity to elongation factor EF-G -Arthrobacter sp.; localisation:mitochondrion; See PMID 10805567
An17g00580	Title: similarity to hypothetical protein T22A6.50 -Arabidopsis thaliana
An17g00590	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An17g00600	Title: similarity to hypothetical protein encoded by An08g09690 - Aspergillus niger
An17g00630	Catalytic activity: Acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine.; Pathway: MetE from Aspergillus nidulans is involved in methionin metabolism.; Title: strong similarity to homoserine O-acetyltransferase metE - Aspergillus nidulans; See PMID 11406274
An17g00640	Remark: the LovC protein is responsible for modulation of polyketide synthase activity in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An17g00650	Remark: Cercosporin is a photosensitizing perylenequinone toxin produced by the plant pathogenic Cercospora fungi. It generates the highly toxic singlet oxygen (1O2) upon exposure to light.; Title: similarity to cercosporin resistance protein Crg1 - Cercospora nicotianae; See PMID 10517336
An17g00660	Title: similarity to hypothetical oxidoreductase SMc01972 - Sinorhizobium meliloti
An17g00670	Title: strong similarity to hypothetical protein EAA63916.1 - Aspergillus nidulans
An17g00680	Title: strong similarity to protein fragment SEQ ID NO:17753 from patent EP1033405-A2 - Arabidopsis thaliana
An17g00690	Complex: COPS6 of M. musculus forms part of the heterooctameric COP9 complex.; Function: the COP9 complex of M. musculus presumably plays a role as a cellular regulator modulating multiple signaling pathways.; Similarity: the COP9 complex of M. musculus shares some structural features with the proteasome regulatory complex.; Title: strong similarity to COP9 subunit 6 COPS6 -Mus musculus; See PMID 9707402
An17g00720	Catalytic activity: NR1 of H. sapiens reduces cytochrome c and metabolizes the one-electron acceptors doxorubicin, menadione, and potassium ferricyanide.; Function: NR1 of H. sapiens presumably plays a role in the metabolic activation of chemicals activated by one-electron reduction.; Title: strong similarity to NADPH-dependent FMN and FAD containing oxidoreductase NR1 - Homo sapiens; cytoplasm; See PMID 10625700
An17g00730	Complex: ETF of P. denitrificans is a heterodimer of alpha and beta chains that binds one molecule of FAD.; Function: ETF of P. denitrificans transfers electrons from the beta-oxidation pathway and other oxidative pathways to the respiratory chain via electron-transferring-flavoprotein dehydrogenase.; Title: strong similarity to electron transfer flavoprotein beta chain ETF-beta - Paracoccus denitrificans; localisation:mitochondrion; See PMID 10642498; See PMID 1576992; See PMID 8376381
An17g00750	Similarity: the Sh3 domain is outside the homology region.; Title: similarity to hypothetical Sh3 domain protein YSC-like 1 - Homo sapiens
An17g00760	Catalytic activity: Peptide + H2O = hydrolyzed peptide (preferential release of a C-terminal arginine or lysine residue).; Function: carboxypeptidase S1 of P. janthinellum is a homolog of the killer factor and prohormone-processing carboxypeptidase KEX1.; Title: strong similarity to carboxypeptidase S1 -Penicillium janthinellum; See PMID 8224168
An17g00770	Function: DnaJ is a molecular chaperone interacting with heat shock transcription factors.; Induction: DnaJ is induced by heat shock.; Title: strong similarity to hypothetical DnaJ-like heat shock protein 17E5.120 - Neurospora crassa
An17g00780	Function: Pbn1p of S. cerevisiae is required for the autocatalytic processing of protease B precursor Prb1p in the ER.; Title: similarity to protease B processing protein Pbn1 - Saccharomyces cerevisiae; See PMID 9649520
An17g00790	Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: strong similarity to hypothetical transcription repressor Rdr1 - Saccharomyces cerevisiae
An17g00800	Similarity: shows some homology to the protein of the patent database entry PATENTPROT:AAY92596.; Similarity: the N-terminus shows similarity to the fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: weak similarity to apoptosis associated protein #11 from patent WO200102550-A2 - Candida albicans
An17g00810	Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe
An17g00820	Catalytic activity: 2 ATP + L-Gln + CO2 + H2O = 2 ADP + phosphate + L-Glu + carbamoyl phosphate.; Complex: arg2 of T. virens constitutes the small (glutamine) subunit of the dimeric enzyme.; Pathway: arg2 of T. virens is involved in arginine biosynthesis.; Similarity: contains a domain with similarity to type-1 glutamine amidotransferases.; Title: strong similarity to arginine-specific carbamoyl phosphate synthase small subunit arg2 -Trichoderma virens; See PMID 9501476
An17g00830	Catalytic activity: tannic acid + H2O = gallic acid + glucose.; Complex: tannase of A. oryzae probably forms a heterooctamer.; Remark: tannase of A. oryzae is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An17g00840	Function: DRG1 of A. thaliana is probably involved in the regulation of vesicle transport in actively growing tissues.; Localization: DRG1 of A. thaliana is localized in cytoplasmatic vesicles of actively growing tissues.; Title: strong similarity to developmentally regulated G-protein DRG1 - Arabidopsis thaliana; intracellular transport vesicles; See PMID 10380799
An17g00850	Complex: Cwf2p of S. pombe is associated with Cpc5p in a 40S RNP complex.; Function: Cwf2p of S. pombe is involved in spliceosome assembly and function.; Title: strong similarity to cdc5-associated ribonucleoprotein subunit cwf2p - Schizosaccharomyces pombe; See PMID 10409726
An17g00860	Catalytic activity: Gcn2p of S. cerevisiae transfers phosphate moieties from ATP to serine/threonine residues of eIF2 alpha.; Function: Gcn2p of S. cerevisiae increases the translation of GCN4, a transcriptional activator of amino-acid biosynthesis genes.; Function: the C-terminal histidyl-tRNA synthetase-like domain of Gcn2p of S. cerevisiae presumably responds to the presence of uncharged tRNA(His) by activating the adjacent protein kinase moiety.; Induction: Gcn2p of S. cerevisiae is transcriptionally activated by Gcn4p, thereby creating a self-enhancing circuit of amino-acid biosynthesis activation under amino-acid starvation conditions.; Similarity: Gcn2p of S. cerevisiae contains a C-terminal domain homologous to histidyl-tRNA synthetase.; Title: strong similarity to eIF2-alpha specific protein kinase Gcn2 - Saccharomyces cerevisiae; See PMID 660141; See PMID 3290651
An17g00870	Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical transcription regulator AAB94013.1 - Sorghum bicolor [truncated ORF]; See PMID 9475753
An17g00880	Remark: the patent does not provide further information about the function of the protein.; Remark: this invention describes novel human nucleic acid (cDNA) sequences (A), that are highly expressed in uterine tumour tissue and which have anticancer and cytostatic activity.; Similarity: the predicted A. niger protein shows strong similarity to human endometrium tumour EST encoded protein 137 of patent DE19817948-A1 and many conserved hypothetical proteins.; Title: strong similarity to endometrium tumour EST encoded protein 137 from patent DE19817948-A1 - Homo sapiens
An17g00890	Function: when expressed in E. coli, the catalytic domain of PPT of R. norvegicus exhibited protein phosphatase activity (dephosphorylation of phosphorylase a) that was inhibitable by okadaic acid.; Similarity: the predicted A. niger protein shows strong similarity to phosphoprotein phosphatase (PPT) of R. norvegicus, which belongs to the fourth subfamily of the PPP-family of protein phosphatases, which includes PP1,PP2A and PP2B (calcineurin).; Title: strong similarity to phosphoprotein phosphatase PPT - Rattus norvegicus; nucleus; See PMID 8077208
An17g00900	Cofactor: SPT4 of S. cerevisiae requires metal binding for its function.; Complex: SPT4 and SPT5 form a complex that does not contain SPT6.; Function: SPT4 of S. cerevisiae is involved in chromatin structure that influences expression of many genes.; Function: SPT4 of S. cerevisiae is involved in transcription elongation.; Function: SPT4 of S. cerevisiae is involved in transcription-coupled repair (TCR). in yeast, the Rad26 protein is implicated specifically in TCR. deletion of the SPT4 gene suppresses the rad26 defect.; Function: SPT4 of S. cerevisiae plays a role in chromosome segregation as it is important for kinetochore function, but not as a structural component of the centromere (CEN) DNA-protein complex.; Remark: some of the cysteine residues are essential to yeast Spt4p function.; Similarity: the predicted A. niger protein shows strong similarity to SPT4 of S. cerevisiae, which belongs to the zinc finger transcriptional regulators.; Title: strong similarity to protein Spt4 -Saccharomyces cerevisiae; nucleus; See PMID 8483459; See PMID 8649393; See PMID 11101522
An17g00910	Catalytic activity: 4-aminobutyrate aminotransferase from A. nidulans catalyses the reaction 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.; Cofactor: 4-aminobutyrate aminotransferase from A. nidulans needs pyridoxal phosphate as a cofactor.; Induction: 4-aminobutyrate aminotransferase from A. nidulans is under positive control by the regulatory gene amdR (also called intA).; Pathway: 4-aminobutyrate aminotransferase from A. nidulans is involved in the metabolism of glutamate,aspartate, alanine, beta-alanine, propanoate and butanoate.; Similarity: the predicted A. niger protein shows strong similarity to 4-aminobutyrate aminotransferase from A. nidulans and many other organisms.; Title: strong similarity to 4-aminobutyrate transaminase gatA - Aspergillus nidulans; cytoplasm; See PMID 2505051
An17g00930	Remark: during fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. C-factor of M. xanthus is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.; Similarity: the predicted A. niger protein shows similarity to the C-factor of M. xanthus, to 17 beta-hydroxysteroid dehydrogenases of vertebrates and many hypothetical proteins of diverse organisms, that belong to the short-chain dehydrogenases/reductases family (SDR) by similarity.; Title: similarity to developmental protein C-factor csgA - Myxococcus xanthus; See PMID 1668187; See PMID 2107980; See PMID 2152896
An17g00940	Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An17g00970	Similarity: the predicted ORF shows similarity to several hypothetical and known aldehyde dehydrogenases with different substrate specificity.; Title: strong similarity to betaine aldehyde dehydrogenase - Avicennia marina; See PMID 11292080
An17g01000	Title: strong similarity to hypothetical protein sll1024 - Synechocystis sp.
An17g01020	Remark: the human patented protein is a polypeptide encoded by one of a large number of 5' ESTs derived from mRNAs encoding secreted proteins.; Title: similarity to secreted protein SEQ ID NO:5560 from patent EP1033401-A2 - Homo sapiens
An17g01050	Function: RAD54 of S. cerevisiae is a DNA-dependent ATPase required for X-ray damage repair, mitotic recombination, and full meiotic recombination.; Similarity: the N-terminal half of the predicted protein shows no similarity with described genes.; Title: similarity to DNA-dependent ATPase Rad54 -Saccharomyces cerevisiae; nucleus; See PMID 9409819; See PMID 9409820; See PMID 9450758; See PMID 9509573
An17g01060	Similarity: mouse P113 is highly homologous to human HIP116, a putative transcription factor interacting with HIV LTR sequences; both show similarity to yeast SNF2/SWI2.; Similarity: the predicted protein shows similarity to different known and putative transcription factors,especially hypothetical proteins of A. thaliana; all are characterized by the presence of several functional domains found in DNA-interacting regulatory proteins, like SNF2 domains, Zn finger domains and helicase domains.; Title: strong similarity to transcription factor P113 - Mus musculus; See PMID 9427542
An17g01070	Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Remark: a putative sequencing error results in an frameshift.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 8987357; See PMID 11065353
An17g01080	Function: F. sporotrichioides TRI7 is required for acetylation of the oxygen on C-4 of the trichotecene T-2 toxin.; Title: weak similarity to member of the trichothecene gene cluster TRI7 - Fusarium sporotrichioides; See PMID 11352533
An17g01090	Title: similarity to hypothetical protein SPCC4G3.18 - Schizosaccharomyces pombe
An17g01100	Similarity: the 3' region of the predicted ORF overlaps with a short fragment of A. niger EST EMBLEST:ANI239805, which probably reprents the 3' UTR of the previous An17g01110, transcribed on the other strand.; Title: similarity to hypothetical protein SPAC637.04 - Schizosaccharomyces pombe
An17g01110	Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Function: complex I transfers electrons from NADH to the respiratory chain; the immediate electron acceptor for the enzyme is believed to be ubiquinone.; Localization: mitochondrial inner membrane; matrix side.; Similarity: the ORF shows similarity to uncharacterized differentiation-associated proteins from H. sapiens.; Similarity: the predicted protein is similar to a novel 17. 2-kDa subunit identified recently by electrospray mass spectrometry.; Similarity: to A. niger ESTs an_1032 and EST SEQ ID NO:4019.; Title: strong similarity to 17.2 kD subunit of NADH:ubiquinone reductase b17.2 - Bos taurus; localisation:mitochondrion; See PMID 9827566
An17g01120	Catalytic activity: phosphatidylglycerophosphate synthase, officially called CDPdiacylglycerol--serine O-phosphatidyltransferase, catalyzes the reaction: CDPdiacylglycerol + L-Serine = CMP + 3-O-sn-Phosphatidyl-L-serine.; Function: PGS1 of S. cerevisiae functions as the committed and rate-limiting step in the biosynthesis of cardiolipin (CL); in eukaryotic cells, CL is found predominantly in the inner mitochondrial membrane and is generally thought to be an essential component of many mitochondrial functions.; Function: PGS1 of S. cerevisiae is also involved in in mitochondrial-mediated control of cell multiplication.; Remark: PGS1 of S. cerevisiae is also called PEL1,YCL003W or YCL004W.; Title: strong similarity to phosphatidylglycerophosphate synthase Pgs1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8252640; See PMID 8553693; See PMID 8666200; See PMID 9335584; See PMID 9545322
An17g01130	Similarity: B7A16. 140 of N. crassa and the predicted protein are similar to S. cerevisiae LTV1, a poorly characterized protein claimed to be involved in low-temperature viability.; Title: strong similarity to hypothetical protein B7A16.140 - Neurospora crassa
An17g01140	Similarity: B7A16. 130 of N. crassa and the predicted protein show similarity to a GTPase of unknown function, human HSR1, that has been localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse; these proteins represent a new subfamily of GTP-binding proteins that has both prokaryote and eukaryote members.; Similarity: strong similarity also to A. oryzae EST SEQ ID NO:4542 of patent WO200056762-A2.; Title: strong similarity to hypothetical conserved protein B7A16.130 - Neurospora crassa; See PMID 8180467
An17g01150	Remark: manual BLASTP homologue PIR:DERTCM.; Title: strong similarity to acyl-CoA dehydrogenase MCAD - Rattus norvegicus; See PMID 2029527
An17g01160	Function: in S. cerevisiae BNS1 (Bypasses Need for Spo12p), which has homology to SPO12, and SPO13, can partially suppress the meiotic defect of spo12 mutants when overexpressed.; Remark: BNS1 of S. cerevisiae is also called YGR230w.; Remark: in S. cerevisiae the SPO12 gene regulates meiotic nuclear division; when sporulated, spo12 mutants undergo a single meiotic nuclear division most closely resembling meiosis II.; Title: similarity to protein Bypasses Need for Spo12p Bns1 - Saccharomyces cerevisiae; See PMID 10564265
An17g01170	Similarity: the predicted protein shows strong similarity also to the human breast cancer gene CH1-9a11-2 of patent WO9738085-A2.; Title: strong similarity to hypothetical membrane protein YOR154w - Saccharomyces cerevisiae
An17g01180	Similarity: the predicted protein shows similarity to several putative and known protein Ser/Thr kinases with different specificity.; Title: similarity to Ser/Thr protein kinase Ksp1 -Saccharomyces cerevisiae; nucleus; See PMID 8676864; See PMID 9020587
An17g01190	Remark: C-terminally truncated ORF due to contig border.; Title: questionable ORF [truncated ORF]
An17g01200	Remark: the ORF is truncated and contains no start codon, due to the end of the contig.; Title: weak similarity to secreted protein gu534_1 from patent WO9846757-A2 - Homo sapiens [truncated ORF]
An17g01230	Title: weak similarity to polyketide synthase module 7 encoded by nidA5 - Streptomyces caelestis
An17g01250	Function: human Vps18 is necessary for the delivery of endocytic and biosynthetic cargo in H. sapiens.; Remark: Vps18 is a human homologue of yeast Class C VPS genes.; Remark: human Vps18 is ubiquitously expressed in peripheral tissues.; Similarity: Vps proteins are predominantly associated with late endosomes/lysosomes.; Similarity: the ORF encoded protein shows also strong similarity to the undescribed DigA protein from A. nidulans.; Title: strong similarity to vacuolar protein sorting protein 18 VPS18 - Homo sapiens; endosome; See PMID 11382755
An17g01260	Title: strong similarity to hypothetical protein CAD21401.1 - Neurospora crassa
An17g01270	Similarity: a N. crassa hypothetical gene shows a much stronger similarity to the predicted protein,involving also the N-terminus.; Similarity: the predicted ORF is longer than MRPL7 of S. cerevisiae, the similarity involving only the C-terminal part.; Title: strong similarity to mitochodrial ribosomal protein of the large subunit Mrpl7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368
An17g01280	Function: nrc-1 of N. crassa is a MAPKK kinase that functions to repress the onset of conidiation.; Similarity: nrc-1 of N. crassa is closely related to the S. cerevisiae STE11 and Schizosaccharomyces pombe byr2 genes, bothe encoding MAPKK kinases necessary for sexual development in these organisms.; Similarity: the N-terminal part of the predicted protein show similarity to other protein kinases.; Title: strong similarity to MAPKK kinase nrc-1 -Neurospora crassa; See PMID 9584090
An17g01290	Title: questionable ORF
An17g01300	Function: the AmdA transcriptional activator from E. nidulans is involved in the induction of the E. nidulans structual gene amdS (acetamidase).; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617
An17g01310	Similarity: the protein contains two classical Zinc finger domains, and shows local weak similarity to poorly characterized mammalian Zinc finger proteins.; Title: similarity to hypothetical protein MUA22.14 -Arabidopsis thaliana
An17g01320	Title: similarity to in E2Fa/Dpa expressing plants upregulated protein SEQ ID NO 1278 from patent WO2004035798-A2 - Arabidopsis thaliana
An17g01330	Catalytic activity: adenosine kinase is a very conserved enzyme catalyzing the reaction ATP + Adenosine = ADP + AMP.; Pathway: Purine metabolism.; Title: strong similarity to adenosine kinase -Cricetulus griseus; See PMID 10606765; See PMID 10964675
An17g01340	Title: similarity to hypothetical protein SPAC14C4.01c - Schizosaccharomyces pombe
An17g01350	Title: strong similarity to hypothetical protein EAA63847.1 - Aspergillus nidulans
An17g01360	Similarity: strong similarity to S. cerevisiae L8. e ribosomal protein means about 80% identity.; Similarity: two A. niger ESTs confirm the gene prediction.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L8.e Pl2b - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 9559554; See PMID 3327609
An17g01370	Function: the E. coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue located in its C- or N-terminal domain,respectively; it is the main agent of the adaptive response of bacteria to alkylating agents.; Function: the previous remark could be of crucial importance in the assessment of the function of the predicted protein, which completely lacks similarity to the C-terminal transferase domain of Ada.; Remark: Ada of E. coli is a bifunctional protein: the O6-methylguanine transferase activity resides in the C-terminal part of the protein; methyl transfer to the N-terminal domain causes it to acquire a sequence-specific DNA binding activity, which directs binding to the regulatory region of several methylation-resistance genes.; Similarity: the similarity of the predicted protein to Ada of E. coli involves only the N-terminal half of both proteins.; Title: similarity to adaptive response regulatory protein Ada - Escherichia coli; See PMID 3529081; See PMID 3887409; See PMID 2982792; See PMID 2987251; See PMID 3009022
An17g01390	Similarity: AAK56937. 1 of C. immitis and the predicted protein are similar to different proteins containing SH3 domains; the domain structure is not well conserved in the predicted protein.; Similarity: althoughl AAK56937. 1 of C. immitis is much shorter than the predicted protein, the two molecules are 75% identitical in the corresponding region.; Similarity: the predicted protein show similarity in particular to the EEN gene family, a group of mammalian proteins expressed in the brain and perhaps involved in vesicular trafficking; the members of this family are nevertheless very poorly characterized in terms of function.; Title: strong similarity to hypothetical SH3 domain-containing protein AAK56937.1 - Coccidioides immitis; See PMID 9122235; See PMID 10764144; See PMID 10816441
An17g01410	Complex: SNF2 of S. cerevisiae is a component of the SWI/SNF global transcription activator complex.; Function: SNF2 of S. cerevisiae acts to assist gene-specific activators and has an effect on chromatin structure.; Remark: SNF2 of S. cerevisiae is also called SWI2,GAM1, TYE3, HAF1, RIC1 or YOR290c.; Title: strong similarity to transcription regulator Snf2 - Saccharomyces cerevisiae; nucleus; See PMID 7623818; See PMID 8871545; See PMID 8939065; See PMID 1886612; See PMID 1901413
An17g01420	Similarity: the predicted protein shows similarity to human genes of unclear function genetically linked to familial adenomatous polyposis.; Title: strong similarity to hypothetical transport protein SPCC830.08c - Schizosaccharomyces pombe
An17g01430	Remark: the A. thaliana homologue, as the vast majority of A. thaliana transcripts, has been patented under patentnumber EP1033405-A2.; Title: similarity to hypothetical protein MUD21.19 -Arabidopsis thaliana
An17g01440	Function: Pex3 of P. angusta is involved in peroxisome biosynthesis.; Localization: Pex3 of P. angusta is an integral peroxisomal membrane protein.; Title: strong similarity to peroxisomal membrane protein PEX3 - Pichia angusta; peroxisome; See PMID 8621531
An17g01450	Remark: TNA1 is necessary for nicotinic acid import into the cell.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: belongs to the allantoate permease family; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621
An17g01460	Title: strong similarity to EST SEQ ID NO:4056 from patent WO200056762-A2 - Aspergillus niger
An17g01470	Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Complex: RNA polymerase I consists of 14 different subunits.; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. RNA polymerase A (I) is essentially used to transcribe ribosomal DNA units.; Function: RPA49 is easily dissociated from the rest of Pol A, producing the form A*, which shows impaired transcriptional activity and increased sensitivity to alpha-amanitin. The function of A49 might be linked to the RNAse H activity that was found associated with this subunit.; Title: similarity to 49 kD subunit of DNA-directed RNA polymerase I Rpa49 - Saccharomyces cerevisiae; nucleus; See PMID 1409638
An17g01480	Catalytic activity: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.; Pathway: glycine, serine and threonine metabolism.; Remark: also strong similarity to 5-aminolevulinic acid synthase from Aspergillus oryzae patent WO9747746-A1.; Remark: hemA of E. nidulans expression was unaffected by dextrose repression, heat shock, or oxygen levels.; Similarity: belongs to the 5-aminolevulinate synthases.; Title: strong similarity to 5-aminolevulinic acid synthase hemA - Aspergillus nidulans; See PMID 8319309
An17g01490	Remark: asynonym for INO80 from S. cerevisiae is YGL150c.; Similarity: to the DNA/RNA helicases, SNF2 family.; Title: strong similarity to DNA helicase Ino80 -Saccharomyces cerevisiae; See PMID 10361278; See PMID 10952318; See PMID 8585324
An17g01530	Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Gene-ID: adhA; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: identical to Aspergillus niger adhA gene patent WO8704464-A.; Similarity: belongs to the Zn-dependent alcohol dehydrogenases.
An17g01540	Remark: transport of 4-aminobutyric acid (GABA) in S. cerevisiae is mediated by three transport systems: the general amino acid permease (GAP1 gene), the proline permease (PUT4 gene), and a specific GABA permease (UGA4 gene) which is induced in the presence of GABA. Induction of UGA4 in the presence of GABA is exerted at the level of UGA4 mRNA accumulation, most probably at the level of transcription itself.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 8455553
An17g01550	Remark: efficient transport out of the prevacuolar compartment requires Nhx1p, and nhx1 delta cells exhibit phenotypes characteristic of the 'class E' group of vps mutants. In addition Nhx1p is required for protein trafficking even in the absence of the vacuolar ATPase.; Title: strong similarity to Na+-H+ antiporter Nha2 -Saccharomyces cerevisiae; See PMID 9507001; See PMID 11102523
An17g01560	Remark: OsSUT1 was expressed in source organs such as leaf blade, leaf sheath and germinating seed whereas little or no expression was observed in some sink organs such as the panicles before heading and the roots.; Remark: strong similarity to 5' EST an_2098 from Aspergillus niger.; Title: strong similarity to sucrose transport protein SUT1 - Oryza sativa; See PMID 9522469
An17g01570	Title: strong similarity to EST an_3450 -Aspergillus niger
An17g01580	Remark: S. cerevisiae Ste12p plays a key role in coupling signal transduction through MAP kinase modules to cell-specific or morphogenesis-specific gene expression required for mating and pseudohyphal (PH)/filamentous growth (FG). Ste12p homologues in the pathogenic yeasts Candida albicans and Filobasidiela neoformans apparently play similar roles during dimorphic transitions.; Title: strong similarity to homeodomain DNA-binding transcription factor ste12 - Aspergillus nidulans; See PMID 10792717
An17g01590	Title: weak similarity to hypothetical protein PFC0680w - Plasmodium falciparum
An17g01630	Title: strong similarity to hypothetical protein SPAC3F10.08c - Schizosaccharomyces pombe
An17g01640	Catalytic activity: N-(5'-Phospho-D-ribosylformimino)-5-amino-1-(5''-phospho-D -ribosyl)-4-imidazolecarboxamide = N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phos pho-D-ribosyl)-4-imidazolecarboxamide.; Pathway: histidine metabolism.; Remark: Soybean histidine biosynthetic enzyme HisA from clone sls1c. pk013. i8 patent WO200024867-A2.; Remark: the patent sequence is used in the construction of a chimeric gene to alter levels of the HisA enzyme in transformed plant cells. It may also be used for discovering compounds that have the ability to inhibit activity of the isomerase, and therefore act as herbicides and fungicides.; Similarity: belongs to the N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphori bosyl)-4-imidazolecarboxamide isomerases.; Title: strong similarity to biosynthetic enzyme HisA from patent WO200024867-A2 - Glycine max
An17g01650	Title: weak similarity to En/Spm-like transposon protein PDF1 - Arabidopsis thaliana
An17g01660	Catalytic activity: acetyl-CoA + histone = CoA + acetylhistone.; Remark: the yeast enzyme acetylates core histones in vitro; supposed to play a role as tightly RNAPII-associated histone acetyltransferase in transcription of DNA packaged in chromatin.; Title: strong similarity to histone acetyltransferase Elp3 - Saccharomyces cerevisiae
An17g01670	Catalytic activity: (EC:6. 2. 1. 4) GTP + succinate + CoA = GDP + orthophosphate + succinyl-CoA; ITP + succinate + CoA = IDP + orthophosphate + succinyl-CoA; GTP + itaconate + CoA = GDP + orthophosphate + itaconyl-CoA; ITP + itaconate + CoA = IDP + orthophosphate + itaconyl-CoA.; Catalytic activity: (EC:6. 2. 1. 5) ATP + succinate + CoA = ADP + orthophosphate + succinyl-CoA.; Function: the rat enzyme catalyzes the stepwise synthesis of succinyl-CoA from succinate, CoA, and GTP in the presence of magnesium ion, involving phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates. The active enzyme is an alpha-beta dimer.; Pathway: Citrate cycle (TCA cycle); Propanoate metabolism; C5-Branched dibasic acid metabolism; Reductive carboxylate cycle (CO2 fixation).; Remark: succinyl-CoA synthetase [succinate-CoA ligase (GDP-forming); EC 6. 2. 1. 4] of rat liver, an alpha beta dimer, is a component of the enzymology of the tricarboxylic acid cycle and functions within the mitochondrial matrix.; Similarity: to succinate-CoA ligase (ADP-forming) alpha chain.; Title: strong similarity to succinyl coenzyme A synthase alpha subunit SYRTSA - Rattus norvegicus; See PMID 3422742
An17g01690	Title: questionable ORF
An17g01710	Remark: Yil120wp was implicated in yeast resistance to ketoconazole and quinidine, but not to the stereoisomer quinine; the gene was thus named QDR1. Qdr1p was proved to alleviate the deleterious effects of quinidine, revealed by the loss of cell viability following sudden exposure of the unadapted yeast population to the drug, and to allow the earlier eventual resumption of exponential growth under quinidine stress.; Remark: alternative name is YIL120w.; Remark: the predicted ORF shows similarity to EST an_2526 from A. niger.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822
An17g01720	Remark: the A. chrysogenum RFX protein CPCR1 recognizes an imperfect palindrome, which resembles binding sites of human RFX transcription factors. One- and two-hybrid experiments with shorter versions of CPCR1 showed that the protein forms a DNA binding homodimer. Nondenaturing electrophoresis revealed that the CPCR1 protein exists in vitro solely in a multimeric, probably dimeric, state.; Title: strong similarity to RFX transcription factor CPCR1 - Penicillium chrysogenum; See PMID 10734077
An17g01730	Title: similarity to hypothetical protein AAK58053.1 - Ophiostoma novo-ulmi
An17g01740	Function: along with Uba2p forms Aos1p heterodimeric activating enzyme for the ubiquitin-like modifyer Smt3p/SUMO in a mechanism reminiscent of the ubiquitin conjugation pathway.; Remark: alternative name for the S. cerevisiae homolog gene AOS1 is YPR180w; Title: strong similarity to Smt3p activating enzyme Aos1 - Saccharomyces cerevisiae; See PMID 9312010
An17g01750	Remark: S. cerevisiae YTP1 gene encodies a type-III integral membrane protein with domains of sequence similarity to mitochondrial electron-transport enzymes.; Title: strong similarity to hypothetical membrane protein Ytp1 - Saccharomyces cerevisiae; See PMID 8635735; See PMID 9271199
An17g01760	Title: similarity to hypothetical protein SPBC409.03 - Schizosaccharomyces pombe
An17g01770	Remark: N-terminal truncated ORF due to end of contig.; Remark: also strong similarity to multiple drug resistance protein AfuMDR1 from Aspergillus fumigatus patent US5914246-A.; Remark: expression of AFUMDR1 in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus fumigatus [truncated ORF]; plasma membrane; See PMID 9373135
An17g01795	Title: weak similarity to protein of retrotransposon Ty1 Tyb - Saccharomyces cerevisiae
An17g01805	Title: weak similarity to protease type 2 Iga1 -Haemophilus influenzae
An17g01815	Alternative name: YPR016c; Function: the S. cerevisiae protein eIF6, is necessary for maximal polysome formation and plays an important role in determining free 60 S ribosomal subunit content.; Title: strong similarity to translation initiation factor Eif6 - Saccharomyces cerevisiae; cytoplasm; See PMID 9891075; See PMID 10206977
An17g01825	Title: strong similarity to huntingtin interacting protein 1 HIF-1 - Homo sapiens
An17g01865	Catalytic activity: ATP + protein <=> ADP + O-phosphoprotein.; Function: E. nidulans spores lacking CmkC germinate with delayed kinetics and a lag in the activation of the cell cycle relevant kinase NIMX(cdc2).; Title: strong similarity to calcium/calmodulin dependent protein kinase cmkC - Aspergillus nidulans; See PMID 10988293
An17g01875	Localization: the mouse Synbindin is structurally related to yeast proteins known to be involved in vesicle transport. Immunoelectron microscopy localized synbindin on postsynaptic membranes and intracellular vesicles within dendrites, suggesting a role in postsynaptic membrane trafficking.; Title: similarity to protein Synbindin - Mus musculus; intracellular transport vesicles; See PMID 11018053
An17g01885	Title: weak similarity to IgA-specific metalloendopeptidase type 1 precursor IGA - Haemophilus influenzae
An17g01925	Remark: alternate names for the S. cerevisiae Hal4 kinase: Sat4 or YOR008W.; Remark: the S. cerevisiae Hal4 and Hal5 kinases are partially redundant. hal4 hal5 double mutants exhibit following phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium,tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.; Title: strong similarity to serine/threonine-specific protein kinase Hal4 -Saccharomyces cerevisiae; See PMID 10207057
An17g01935	Title: weak similarity to HIC-1 polypeptide from patent WO9614877-A1 - Homo sapiens
An17g01945	Function: the S. cerevisisae Rvs161 protein is a component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. S. cerevisiae rvs161 mutations result in sensitivity to carbon, nitrogen and sulfur starvation.; Remark: alternate names for the S. cerevisiae Rvs161 protein: End6, Fus7, Spe161 or YCR009C.; Similarity: the predicted A. niger protein shows strong similarity to protein Rvs161 from S. cerevisiae and amphiphysins of higher eukaryotes.; Title: strong similarity to protein Rvs161 -Saccharomyces cerevisiae; cytoskeleton; See PMID 10992286; See PMID 1776363; See PMID 7891662; See PMID 9614182
An17g01955	Similarity: the ORF encoded protein shows also similarity to some putative aminoacyl-tRNA hydrolases.; Title: similarity to rhoGAP homolog DdRacGAP -Dictyostelium discoideum; See PMID 9188459
An17g01965	Title: similarity to heptaprenyl diphosphate synthetase ORFII from patent EP699761-A2 - Bacillus stearothermophilus
An17g01975	Function: the S. cerevisiae Imp4 protein is a component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It interacts physically with the U3 snoRNP specific protein, Mpp10. It is required for the early cleavages at sites A0, A1 and A2 of the pre ribosomal RNA to yield pre 18s ribosomal RNA processing.; Remark: alternate name for S. cerevisiae Imp4: YNL075W.; Title: strong similarity to component of the U3 snoRNP Imp4 - Saccharomyces cerevisiae; nucleus; See PMID 10409734
An17g01977	Function: A mutation in Grs1 from S. cerevisiae affects 3'-end formation.; Remark: Grs1 from S. cerevisiae encodes the cytoplasmic glycyl-tRNA synthetase.; Title: strong similarity to glycine-tRNA ligase Grs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10224248; See PMID 10874035
An17g02010	Function: the S. cerevisiae kinase Cla4 is involved in budding and cytokinesis and interacts with Cdc42.; Remark: alternate names for S. cerevisiae Cla4: Erc10 or YNL298W.; Title: strong similarity to serine/threonine protein kinase Cla4 - Saccharomyces cerevisiae; See PMID 9271384; See PMID 11134337
An17g02020	Catalytic activity: ATP + NADH <=> ADP + NADPH.; Function: the NADH kinase may be involved in maintaining the level of triphosphopyridine nucleotide in the mitochondria.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to NADH kinase from patent JP09131185-A - Pichia membranaefaciens
An17g02030	Title: strong similarity to 2-acyltransferase from patent WO9413814-A - Zea mays
An17g02040	Remark: alternate names for S. cerevisiae Ctr9: Cdp1 or YOL145C.; Similarity: the ORF encoded protein shows also strong similarity to the S. pombe homolog of the S. cerevisiae Ctr9 protein Tpr1 from which the gene has been identified as suppressor of the S. cerevisiae Delta trk1,2 potassium uptake deficient phenotype (Pubmed 10471809). The S. cerevisiae Ctr9 protein seems to be better characterized.; Title: strong similarity to protein required for normal CLN1 and CLN2 G1 cyclin expression Ctr9 -Saccharomyces cerevisiae; See PMID 8978028; See PMID 10219085
An17g02060	Remark: due to contig end.; Title: weak similarity to hypothetical gastric mucin clone PGM-2A - Sus scrofa [truncated ORF]
An17g02070	Title: strong similarity to hypothetical protein ES2 - Mus musculus
An17g02075	Function: The expression of the yam8(+) cDNA from S. pombe in the S. cerevisiae mid1 mutant cells partially remediated the mid phenotype and resulted in a slight increase in Ca(2+) uptake activity.; Function: the yam8(+) cDNA from S. pombe, placed under the S. cerevisiae TDH3 promoter, partially complemented the mating pheromone-induced death (mid) phenotype of the S. cerevisiae mid1 mutant.; Title: strong similarity to stretch-activated Ca2+-permeable channel protein homolog yam8p -Schizosaccharomyces pombe; See PMID 10694511
An17g02080	Title: strong similarity to hypothetical protein SPBC27B12.12c - Schizosaccharomyces pombe
An17g02090	Catalytic activity: ATP + L-homoserine <=> ADP + O-phospho-L-homoserine; Title: strong similarity to homoserine kinase Thr1 -Saccharomyces cerevisiae
An17g02095	Function: Overexpression of SPC1 from S. cerevisiae supresses the conditional sec11 mutation.; Function: Spc1p from S. cerevisiae co-purifies and genetically interacts with Sec11p, a subunit of the signal peptidase that catalyzes the cleavage of signal peptides and the degradation of some membrane proteins within the endoplasmic reticulum (ER).; Function: Spc1p from S. cerevisiae is not required for cell growth or the proteolytic processing of tested proteins in yeast.; Function: a deletion mutant of SPC1 from S. cerevisiae is synthetically lethal with a conditional mutation affecting Sec11p.; Similarity: Spc1p from S. cerevisiae is the homologue to mammalian signal peptidase subunit SPC12.; Title: similarity to signal peptidase subunit Spc1 -Saccharomyces cerevisiae; See PMID 8663399; See PMID 8910564
An17g02100	Complex: human ring-box protein 1 binds VHL protein,CUL1, CUL2 and Elongins B and C.; Complex: human ring-box protein 1 is a component of both the VHL and SCF/Cdc4 complexes.; Function: the yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCF/Cdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition.; Similarity: the predicted A. niger protein shows strong similarity to the human ring-box protein 1 (RBX1),which belongs to the ring finger proteins.; Title: strong similarity to ring-box protein 1 RBX1 - Homo sapiens; See PMID 10213691
An17g02110	Title: weak similarity to hypothetical protein KIAA0324 - Homo sapiens
An17g02120	Catalytic activity: UDP-glucose + {(1,3)-beta-D-glucosyl}(N) <=> UDP + {(1,3)-beta-D-glucosyl}(N+1); Title: strong similarity to 1,3-beta-glucan synthase gs-1 - Neurospora crassa
An17g02130	Title: strong similarity to protein fragment SEQ ID NO:28055 from patent EP1033405-A2 - Arabidopsis thaliana
An17g02140	Title: strong similarity to vanadate resistance protein Van2 - Saccharomyces cerevisiae
An17g02150	Title: similarity to hypothetical protein YIL096c -Saccharomyces cerevisiae
An17g02160	Title: similarity to erythroblast macrophage protein EMP - Homo sapiens; See PMID 9763581
An17g02170	Title: strong similarity to centromere/microtubule-binding protein Cbf5 - Saccharomyces cerevisiae
An17g02180	Title: similarity to hypothetical eIF-3 p110 subunit - Caenorhabditis elegans
An17g02190	Title: similarity to hypothetical protein SPBC1105.15c - Schizosaccharomyces pombe
An17g02200	Title: similarity to hypothetical chorismate mutase/prephenate dehydratase pheA - Aquifex aeolicus
An17g02210	Title: strong similarity to peptide chain release factor eRF-1 - Homo sapiens
An17g02220	Title: strong similarity to hypothetical protein YJR001w - Saccharomyces cerevisiae
An17g02230	Title: strong similarity to hypothetical protein YBR141c - Saccharomyces cerevisiae
An17g02240	Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L23a - Rattus norvegicus; cytoplasm
An17g02250	Title: strong similarity to protein G10 - Xenopus laevis
An17g02270	Similarity: HNF-3beta of X. laevis is a member of the HNF-3/fork head transcription factor family.; Title: similarity to transcription factor HNF-3beta - Xenopus laevis; nucleus; See PMID 8155584
An17g02280	Catalytic activity: ATP + L-Aspartate = ADP + 4-Phospho-L-aspartate.; Remark: the synonyme for HOM3 from S. cerevisiae is YER052c.; Title: strong similarity to aspartate kinase Hom3 -Saccharomyces cerevisiae; See PMID 2892836
An17g02285	Title: similarity to kidney injury associated molecule HW034 protein 2 from patent WO9853071-A1 - Rattus sp.
An17g02287	Title: similarity to sequence of the HAP-1 protein from patent WO9910482-A1 - Caenorhabditis elegans
An17g02290	Complex: MYO2 of S. cerevisiae belongs to the actin-associated motorproteins; Function: MYO2 of S. cerevisiae is involved in vacuole inheritance; polarized growth and secretion.; Function: MYO2 of S. cerevisiae plays a role in vesicle transport along actin cables to the bud site.; Title: strong similarity to myosin Myo2 -Saccharomyces cerevisiae; cytoskeleton; See PMID 2016335
An17g02300	Function: NAP-1 is involved in assembling histones into an octamer.; Phenotype: nap-1 null mutant cells do not experience benomyl-induced mitotic delay possibly because absence of Nap1p increases microtubule stability.; Phenotype: nap-1 null mutants have delay at the short spindle stage of mitosis.; Title: strong similarity to nucleosome assembly protein I Nap-i - Saccharomyces cerevisiae; nucleus; See PMID 2016313
An17g02310	Function: overexpression of SPF1 of S. cerevisiae gives resistance against Pichia farinosa killer toxin.; Remark: the ORFencoded protein also shows similarity to other transporting ATPases.; Title: similarity to Ca2+-transporting ATPase Spf1 -Saccharomyces cerevisiae; See PMID 10361284
An17g02320	Function: SGV1 is involved in pheromone adaptation pathway and in cell cycle.; Function: SGV1 probably acts by phosphorylating the G1 cyclins or the Ste4p.; Phenotype: sgv1 knockout mutation is suppressed by activated Cln3p.; Remark: the ORF encoded protein show similarity to many hypothetical protein kinases and also contains corresponding Prosite and PFAM Domains.; Title: strong similarity to protein kinase Sgv1 -Saccharomyces cerevisiae; See PMID 8293972; See PMID 1828190
An17g02330	Catalytic activity: SerA of E. coli catalyzes the reaction of 3-phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH.; Pathway: SerA of E. coli catalyzes the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis.; Similarity: SerA of E. coli belongs to the D-isomer specific 2-hydroxyacid dehydrogenases family.; Title: strong similarity to phosphoglycerate dehydrogenase serA - Escherichia coli; See PMID 7719856; See PMID 3017965
An17g02340	Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).; Similarity: SES1 of S. cerevisiae is a member of class II aminoacyl-tRNA synthetases.; Title: strong similarity to cytosolic serine--tRNA ligase Ses1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3031581
An17g02350	Function: rheb binds [alpha-32P]GTP.; Similarity: rheb is a member of the ras-related GTP-binding proteins.; Title: strong similarity to ras-related GTP-binding protein rheb - Homo sapiens; See PMID 8543055
An17g02360	Title: strong similarity to hypothetical protein CAD70983.1 - Neurospora crassa
An17g02370	Catalytic activity: FUR1 of S. cerevisiae catalyzes the reaction of UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: FUR1 of S. cerevisiae is involved in the salvage pathway of pyrimidine metabolism.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to uracil phosphoribosyltransferase Fur1 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 2189783
An17g02380	Remark: ORF is identical to EST an_3047 of Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC1B3.02c - Schizosaccharomyces pombe
An17g02390	Remark: RP10B was previously confused with MFT1.; Remark: RP3B, PLC2, KRP-Y1 and RPS1B are alternative names for RP10B.; Remark: the ORF contains a putative sequencing error at position 2693.; Similarity: RP10B belongs to the S3AE family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rp10b - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 9396790; See PMID 9421530
An03g00010	Catalytic activity: 5-oxoprolinases catalyse ATP + 5-oxo-L-proline + 2 H(2)O <=> ADP + phosphate + L-glutamate.; Function: 5-oxoprolinases catalyze a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate, which is e. g. necessary in glutathione metabolism.; Remark: OPLAH of R. norvegicus is also called 5-oxo-L-prolinase, pyroglutamase or 5-OPase.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: additionally to 5-oxoprolinases, the ORF shows some similarity to N-methylhydantoinases (EC 3. 5. 2. 14) from different species, which also have the property of hydrolyzing the imide bond of 5-membered rings.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 2563377; See PMID 8943290
An03g00020	Similarity: the similarity of the ORF to the probable transcription factor btd of S. pombe is restricted to the N-terminal half of both putative proteins.; Title: similarity to hypothetical transcription factor btd - Schizosaccharomyces pombe
An03g00030	Similarity: the ORF shows similarity to several putative oxidoreductases with various function.; Title: strong similarity to hypothetical 3-hydroxyisobutyrate dehydrogenase homolog b0509 -Escherichia coli; See PMID 10989433
An03g00040	Catalytic activity: dihydrodipicolinate synthases catalyse L-aspartate 4-semialdehyde + pyruvate <=> dihydrodipicolinate + 2 H(2)O.; Function: dapA of C. glutamicum is involved in the lysine biosynthesis by catalyzing the first step in diaminopimelate and lysine biosynthesis.; Similarity: the ORF shows similarity to several bacterial dihydrodipicolinates.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8659901; See PMID 9559056; See PMID 10498736
An03g00050	Catalytic activity: aspartate transaminases catalyse e. g. L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate.; Function: aspartate transaminases are involved in a variety of amino acid biosynthesis reactions.; Remark: a possible sequencing error occured at position 13058 leading to a stop codon, 1 base has been removed. A possible sequencing error occured at position 12469 leading to a stop codon, 1 base has been changed to N.; Title: strong similarity to cytosolic aspartate transaminase AspAT - Gallus gallus [putative frameshift]; putative frameshift
An03g00060	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Phenotype: the null mutant of S. cerevisiae DAL5 is viable, but unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae is also called J223,YJR152w or UREp1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563
An03g00070	Remark: the ORF is only 31 amino acids long.; Title: questionable ORF
An03g00080	Remark: the ORF is N-terminally truncated due to contig border.
An03g00090	Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 80 amino acids long.; Title: questionable ORF
An03g00100	Remark: the intron-exon structure is suboptimal.
An03g00130	Function: SDH of G. oxydans is able to convert D-sorbitol to 2-keto-L-gulonate (2-KLGA).; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759914) an_2856.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities, especially to choline dehydrogenases.; Title: strong similarity to FAD-dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans
An03g00140	Remark: the ORF shows similarity to several putative oxidoreductases from various species.; Title: strong similarity to hypothetical cytochrome P450 oxidoreductase - Streptomyces lividans
An03g00160	Function: the tamA gene of A. nidulans has a positive role together with areA in regulating the expression of genes subject to nitrogen metabolite repression.; Similarity: the ORF shows similarity to several transcription activators.; Title: strong similarity to transcription activator tamA - Aspergillus nidulans; nucleus; See PMID 8655534; See PMID 10471703; See PMID 11459183; See PMID 1105154
An03g00170	Localization: mMCT2 from mouse was also expressed in a small subset of microtubule-associated protein-2-positive elements, indicating a neuronal localization.; Localization: strong immunoreactivity for mMCT2 transporter from mouse was found in glia limitans,ependymocytes and several microvessel-like elements.; Remark: monocarboxylic acids, i. e., lactate,pyruvate, and ketone bodies, can be utilized by the brain as alternative energy substrates.; Remark: the expression of the monocarboxylate transporters mMCT2 from M. musculus is limited, with high levels of expression confined to testes, kidney, stomach,and liver and lower levels in lung, brain, and epididymal fat.; Title: strong similarity to monocarboxylate transporter mMCT2 - Mus musculus; plasma membrane; See PMID 9725820; See PMID 11098125
An03g00180	Catalytic activity: hydroxylation of n-alkanes at the terminal position.; Function: together with an NADPH cytochrome p450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.; Similarity: belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 alkane hydroxylase ALK2 - Debaryomyces hansenii; See PMID 9931473
An03g00190	Function: Eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Gene-ID: pelB; Similarity: pelB is a member of the Aspergillus niger pectin lyase multigene family.; See PMID 9309173; See PMID 1495474
An03g00200	Title: weak similarity to NifA-regulated gene nrgA -Bradyrhizobium japonicum
An03g00210	Title: similarity to hypothetical protein encoded by An16g01170 - Aspergillus niger
An03g00230	Function: gabA encodes the gamma-amino-n-butyrate (GABA) permease of the fungus A. nidulans.; Remark: transcript level analyses demonstrate that gabA from A. nidulans is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An03g00240	Title: weak similarity to filamentous muscle protein titin - Homo sapiens
An03g00250	Function: Slg1 from S. cerevisiae is a cell surface sensor for cell integrity signaling in S. cerevisiae.; Function: the Slg1 protein from S. cerevisiae is proposed to play a regulatory role in bud emergence or stationary phase.; Phenotype: deletion of slg1 in S. cerevisiae results in cell lysis during growth at elevated temperatures.; Phenotype: deletion of slg1 in S. cerevisiae results in sensitivity against caffeine.; Remark: synonyms for Slg1 from S. cerevisiae are Hcs77, Wsc1 and YOR008c.; Title: strong similarity to protein equired for cell wall integrity Slg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9613583; See PMID 10660075; See PMID 11113201
An03g00260	Title: similarity to hypothetical protein CAE47968.1 - Aspergillus fumigatus
An03g00280	Remark: The matched sequence represents a S. antibioticus tyrosinase and tyrosinase activator protein fusion enzyme.; Title: similarity to tyrosinase and tyrosinase activator protein fusion enzyme from patent WO9513386-A -Streptomyces antibioticus
An03g00290	Function: pth11 mutants of M. grisea are nonpathogenic due to a defect in appressorium differentiation.; Localization: a M. grisea pth11-green fluorescent protein fusion localizes to the cell membrane and vacuoles.; Remark: Plant pathogenic fungi like M. grisea differentiate a highly specialized infection cell called an appressorium to infect their hosts.; Remark: pth11 from M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An03g00300	Title: weak similarity to megakaryocyte stimulating factor MSF from patent WO200064930-A2 - Homo sapiens
An03g00310	Remark: the gene for rickettsial outer-membrane protein A (rOmpA)is a distinguishing feature of the spotted fever group (SFG) rickettsiae.; Title: similarity to rickettsial outer membrane protein A rOmpA - Rickettsia conorii; outer membrane; See PMID 9384303; See PMID 9734038
An03g00320	Remark: the matched protein from A. chrysogenum is involved in biosynthesis of cephalosporin C.; Similarity: the ORF encoded protein shows also similarities to transport proteins.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An03g00340	Remark: ORF contains 1 frameshift, due to a putative sequencing errors.; Remark: The matched protein from C. glutamicum is used to maintain homeostasis in C. glutamicum or help the microorganism to adapt to different environmental conditions.; Title: strong similarity to protein sequence SEQ ID NO:426 from patent WO200100842-A2 - Corynebacterium glutamicum [putative sequencing error]
An03g00350	Complex: the bphC enzyme from P. stutzeri is a homo-octamer.; Function: the protein bphC from P. stutzeri catalyzes the extradiol ring cleavage of 2,3-dihydroxybiphenyl as a key enzyme in the biphenyl/PCB (Poly Chlorinated Biphenyls) degradation.; Remark: bphC from P. stutzeri is an extradiol type catecholic dioxygenase, is a non-heam iron-containing enzyme.; Title: strong similarity to 3-dihydroxybiphenyl-1,2-dioxygenase bphC - Pseudomonas stutzeri; See PMID 9095556; See PMID 11293547
An03g00360	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to rotein fragment SEQ ID NO:34012 from patent EP1033405-A2 - Arabidopsis thaliana
An03g00370	Induction: the expression of paxM from P. paxilli in submerged liquid cultures of P. paxilli increased dramatically with the onset of paxilline biosynthesis.; Remark: The indole-diterpene paxilline is a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Remark: The indole-diterpene paxilline is synthezised by a gene cluster of 17 genes including the FAD-dependent monooxycenase paxM from P. paxilli.; Title: similarity to monooxygenase paxM -Penicillium paxilli; See PMID 11169115
An03g00380	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:11222 from patent EP1033405-A2 - Arabidopsis thaliana
An03g00390	Title: weak similarity to immunoglobulin binding factor activity IBF from patent EP155192-A - Mus musculus
An03g00400	Complex: Hsp42 from S. cerevisiae multimerizes with itself .; Function: S. cerevisiae hsp42 mutants which are subjected to moderate thermal stress reorganized the actin cytoskeleton more slowly than wild-type cells.; Remark: the synonym for Hsp42 from S. cerevisiae is YDR171w.; Title: similarity to heat shock protein Hsp42 -Saccharomyces cerevisiae; See PMID 8576246; See PMID 9199338
An03g00410	Function: glutaminyl-tRNA can be formed by direct acylation by glutaminyl-tRNA synthetase or alternatively by transamidation of incorrectly charged tRNA by the Glutamyl-tRNA(Gln) amidotransferase.; Function: may be involved in biosynthesis of asparagine in the asparagine prototroph D. radiodurans.; Title: strong similarity to glutamyl-tRNA(Gln) amidotransferase subunit A - Deinococcus radiodurans; See PMID 9789001
An03g00420	Title: similarity to hypothetical integral membrane protein pth11 like hypothetical protein CAC28570.2 -Neurospora crassa
An03g00430	Remark: a fumonisin esterase enzyme with at least one fumonisin degradative enzyme is for example useful for detoxifying fumonisin or a structurally related mycotoxin present in harvested grain.; Remark: fumonisins are highly toxic to certain livestock and are potential carcinogens.; Remark: the matched sequence encodes a permease involved in fumonisin degradation.; Title: strong similarity to permease involved in fumonisin degradation from patent WO200105980-A1 -Exophiala spinifera; plasma membrane
An03g00450	Catalytic activity: Acetoacetate + H+ = Acetone + CO2.; Complex: adc from C. acetobutylicum forms a homododecamer.; Induction: the expression of adc from C. acetobutylicum is induced by linear fatty acids (up to butyrate).; Title: similarity to acetoacetate decarboxylase adc - Clostridium acetobutylicum; See PMID 8226639; See PMID 2268159
An03g00460	Catalytic activity: (R)-6-Hydroxynicotine + H2O + O2 = 1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2.; Cofactor: FAD flavoprotein.; Pathway: degradation of nicotine (inducible).; Remark: The expression of enzymatically active 6-HDNO from A. oxidans requires the covalent attachment of FAD to the polypeptide chain and phosphoenolpyruvate.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2680607; See PMID 3036509; See PMID 3056722
An03g00470	Title: strong similarity to hypothetical protein EAA48619.1 - Magnaporthe grisea
An03g00480	Catalytic activity: Catalytic activity: 2-Acetolactate + CO2 = 2 Pyruvate.; Cofactor: FAD, thiamine pyrophosphate and magnesium ion.; Function: the ilv1 from S. pombe was shown to encode a functional subunit of acetolactate synthase by complementation of an S. cerevisiae strain deleted for the ILV2 locus.; Pathway: ilv1 from S. pombe catalyzes the first step in valine and isoleucine biosynthesis.; Title: strong similarity to acetolactate synthase ilv1p - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 8299177
An03g00490	Catalytic activity: (S)-2-Hydroxy-2-methyl-3-oxobutanoate = (R)-2-Acetoin + CO2.; Remark: a B. subtilis strain harboring the aldB gene from B. brevis on a recombinant plasmid processed and secreted the alpha-acetolactate decarboxylase aldB.; Title: strong similarity to alpha-acetolactate decarboxylase aldB - Bacillus brevis; See PMID 2198252
An03g00500	Function: the matched protein from A. fumigatus is related to a enzyme of microbial origin which cleaves disaccharide glycosides, in particular beta-primeveroside.; Title: strong similarity to diglycosidase related protein SEQ ID NO:10 from patent WO200018931-A1 -Aspergillus fumigatus
An03g00530	Catalytic activity: salicylate hydroxylases converts Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Function: NahW of P. stutzeri exhibits a broad substrate specificities and metabolize salicylate,methylsalicylates, and chlorosalicylates.; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Remark: in P. stutzeri exist two independent salicylate hydroxylases nahG and nahW, both are in involved in naphthalene degradation, but are not located in the same transcription unit.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An03g00540	Title: questionable ORF
An03g00550	Title: strong similarity to hypothetical protein encoded by An03g00560 - Aspergillus niger
An03g00560	Title: strong similarity to hypothetical protein encoded by An03g00550 - Aspergillus niger
An03g00580	Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 protein eln2 SEQ ID NO:1 from patent JP2000152788-A - Coprinus cinereus; See PMID 10779399
An03g00590	Catalytic activity: 2-trans,6-trans-farnesyl diphosphate = trichodiene + diphosphate.; Function: Tri5 of G. zeae encodes the first enzyme in the trichothecene biosynthetic pathway, the trichodiene synthase.; Pathway: the trichodiene synthase Tri5 from G. zeae is involved in the Terpenoid biosynthesis.; Phenotype: Reduced virulence of G. zeae is caused by disruption of the trichothecene toxin biosynthetic gene encoding trichodiene synthase Tri5.; Phenotype: trichothecene production is disabled by specific disruption of the trichodiene synthase gene Tri5 of G. zeae.; Title: strong similarity to trichodiene synthase Tri5 - Gibberella zeae; See PMID 8589414; See PMID 9274012; See PMID 10931910; See PMID 11425709
An03g00600	Title: weak similarity to mitogen ERK kinase kinase MEKK-2 from patent US5981265-A - Homo sapiens
An03g00610	Title: similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger
An03g00620	Title: weak similarity to semaphorin Y from patent WO9811216-A1 - Rattus norvegicus
An03g00640	Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids.; Similarity: mtr of N. crassa belongs to the Amino Acid/Auxin Permease (AAAP) family.; Title: similarity to neutral amino acid permease mtr - Neurospora crassa [truncated ORF]; plasma membrane; See PMID 1838345; See PMID 8001794
An03g00650	Function: AM-toxin of A. alternata is a cyclic peptide host-specific toxin.; Phenotype: disruption of AM-toxin synthetase (AMT) resulted in toxin-minus mutants.; Similarity: the A. niger protein shows similarity to other fungal peptide synthetases.; Title: similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An03g00660	Catalytic activity: taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.; Remark: taurine/alpha-ketoglutarate dioxygenase (TauD), a member of the broad class of non-heme Fe(II) oxygenases, converts taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde while decomposing alpha-ketoglutarate (alphaKG) to form succinate and CO(2).; Remark: the Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Title: similarity to taurine dioxygenase tauD -Escherichia coli; See PMID 9287300; See PMID 10563813
An03g00670	Function: nos of A. tumefaciens catalyzes the formation of nopaline by the reductive condensation of alpha-ketoglutaric acid and arginine.; Function: nos of A. tumefaciens is involved in the induction of tumors (crown gall) in dicotyledonous plants.; Title: similarity to D-nopaline dehydrogenase nos -Agrobacterium tumefaciens; See PMID 476084; See PMID 7153689
An03g00680	Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Similarity: the predicted ORF shows similarity to multidrug transporter from different species and with various specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe
An03g00720	Title: strong similarity to EST SEQ ID NO:4295 from patent WO200056762-A2 - Aspergillus niger
An03g00730	Catalytic activity: AO-I catalyses formation of hydrogen peroxide from butyl amine, or benzylamine by oxidative deamination. RCH(2)NH(2) + H(2)O + O(2) <=> RCHO + NH(3) + H(2)O(2).; Function: the A. niger homolog AO-I is located in the cell wall and may function as detoxifying agent,preventing amines from entering and damaging the cell.; Induction: A. niger AO-I is highly expressed in cells grown on n-butylamine as a single nitrogen source.; Title: strong similarity to copper amine oxidase AO-I from patent JP08070872-A - Aspergillus niger; cell wall
An03g00740	Remark: alternate name for S. cerevisiae Dcw1 is YKL046c.; Title: strong similarity to hypothetical protein Dcw1 - Saccharomyces cerevisiae
An03g00750	Function: The Aspergillus nidulans homolog prnA is a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Induction: The transcription of the A. nidulans prnA is neither self-regulated nor significantly affected by carbon and/or nitrogen metabolite repression.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360
An03g00770	Remark: The Aspergillus fumigatus homolog rAsp f 4 is a non-secreted protein of unknown function and is related to allergic bronchopulmonary aspergillosis (ABPA) in human.; Title: strong similarity to hypothetical allergic bronchopulmonary aspergillosis allergen rAsp f 4 from patent WO9828624-A1 - Aspergillus fumigatus
An03g00790	Catalytic activity: E. coli rnc performs an endonucleolytic cleavage to 5'-phosphomonoester.; Function: E. coli homolog rnc is a endoribonuclease specific for double stranded RNA.; Function: E. coli rnc is involved in processing and maturation of ribosomal and tRNAs and participates in regulation of mRNA stability and stimulation of translation.; Title: similarity to ribonuclease III rnc -Escherichia coli
An03g00830	Similarity: similar to a repetitive element in H. sapiens MUC2 and other mucins of approximately 350 amino acids.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens
An03g00840	Remark: blastp matches are unspecific.; Title: strong similarity to EST an_3113 -Aspergillus niger
An03g00850	Pathway: paxC of P. paxilli is part of a gene cluster involved in the synthesis of indole-diterpene paxilline, a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Remark: the A. niger protein contains BLOCKS and PFAM domains corresponding to polypreny synthetase.; Remark: the adjacent A. niger ORF shows similarity to paxG of P. paxilli that is also involved in the synthesis of indole-diterpene paxilline.; Remark: the molecular function of paxC has not been described.; Title: strong similarity to hypothetical prenyl transferase paxC - Penicillium paxilli
An03g00860	Catalytic activity: farnesyltranstransferases catalyse the reaction trans-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.; Pathway: paxG of P. paxilli is involved in the synthesis of indole-diterpene paxilline, a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Similarity: the predicted protein of A. niger shows similarity to geranylgeranyl diphosphate synthases, which are officially named farnesyltranstransferases.; Title: strong similarity to geranylgeranyl pyrophosphate synthase paxG - Penicillium paxilli; See PMID 11169115
An03g00870	Similarity: the predicted A. niger protein is similar to putative zinc finger proteins of the Kruppel type.; Title: strong similarity to hypothetical protein encoded by An12g10520 - Aspergillus niger
An03g00880	Title: similarity to hypothetical 2-dehydropantoate 2-reductase - Schizosaccharomyces pombe
An03g00890	Complex: krd of Z. rouxii exists as a monomer.; Function: ketoreductase of Z. rouxii catalyzes the asymmetric reduction of selected ketone substrates of commercial importance, like alpha-ketolactones,alpha-ketolactams, and diketones.; Remark: substrate specificity, lack of a catalytic metal, and extent of protein sequence identity to known reductases suggests that the enzyme falls into the carbonyl reductase enzyme class.; Remark: the protein sequence of ketoreductase of Z. rouxii is covered by patent EP918090-A2 (AC# AAY05769).; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208
An03g00900	Title: strong similarity to hypothetical protein SC6A5.32c - Streptomyces coelicolor
An03g00910	Remark: the patent does not give additional information about the function of the protein.; Title: strong similarity to sequence 385 from patent WO0100842-A - Corynebacterium glutamicum
An03g00920	Title: strong similarity to hypothetical protein SPCC757.02c - Schizosaccharomyces pombe
An03g00930	Remark: the ORF is short in length (88 amino acids).
An03g00940	Catalytic activity: endo-1,4-beta-xylanase A of A. niger hydrolyses 1,4-beta-D-xylosidic linkages in xylans,which are the major constituent of plant hemicellulose.; Gene-ID: xynA; Remark: due to the complex composition of xylan, a spectrum of enzyme activities is necessary for the complete hydrolysis of this polysaccharide. endo-xylanases (E. C. 3. 2. 1. 8) are only capable of hydrolysing the xylan backbone at non-modified residues. therefore microorganisms synthesize a number of enzymes capable of removing substituents from the xylan backbone, e. g. a-L-arabinofuranosidase B (ABFB)(E. C. 3. 2. 1. 55), acetyl xylan esterase (AXEA) (E. C. 3. 1. 1. 6) and (1,4)-b-D-arabinoxylan arabinofuranohydrolase (AXHA). these enzymes,which were all identified in various Aspergillus species,show strong synergistic effects with endo-xylanase activity resulting in an enhanced degradation of xylan.; Similarity: the predicted A. niger protein is 100% identical to the translated protein sequence of patent WO9713853-A/7 (AC# A62445). however, splice donor (AT) and acceptor (AC) sites of the 8th intron do not fit the consensus sequences of intron boundaries, which are GT and AG, respectively.; extracellular/secretion proteins; See PMID 8948110; See PMID 10422261; See PMID 10833405
An03g00960	Catalytic activity: AXHA of A. niger hydrolyses terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: AXHA of A. niger releases 1,2-a- and 1,3-a- linked arabinofuranosyl groups from arabinoxylans and arabinoxylan-derived oligosaccharides but not from other arabinose-containing substrates such as arabinans and arabinogalactans.; Gene-ID: axhA; Remark: due to the complex composition of xylan, a spectrum of enzyme activities is necessary for the complete hydrolysis of this polysaccharide. endo-xylanases (E. C. 3. 2. 1. 8) are only capable of hydrolysing the xylan backbone at non-modified residues. therefore microorganisms synthesize a number of enzymes capable of removing substituents from the xylan backbone, e. g. a-L-arabinofuranosidase B (ABFB)(E. C. 3. 2. 1. 55), acetyl xylan esterase (AXEA) (E. C. 3. 1. 1. 6) and (1,4)-b-D-arabinoxylan arabinofuranohydrolase (AXHA). these enzymes,which were all identified in various Aspergillus species,show strong synergistic effects with endo-xylanase activity resulting in an enhanced degradation of xylan.; Similarity: (1,4)-beta-D-arabinoxylan arabinofuranohydrolase (axhA) of A. niger belongs to family 62 of glycosyl hydrolases.; extracellular/secretion proteins; See PMID 9000377
An03g00970	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; Title: strong similarity to hypothetical protein encoded by An08g12110 - Aspergillus niger
An03g00980	Title: strong similarity to hypothetical protein CAD70785.1 - Neurospora crassa
An03g00990	Remark: the ORF has an unusual intron/exon structure for A. niger.
An03g01000	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An03g01010	Catalytic activity: CLN2 of H. sapiens releases an N-terminal tripeptide from a polypeptide.; Remark: a partial protein sequence of CLN2 of H. sapiens, described as lung cancer associated polypeptide sequence SEQ ID 618, is covered by patent WO200055180-A2 (AC# AAB58280).; Remark: defects in CLN2 are the cause of classical late-infantile neuronal ceroid lipofuscinosis (lincl) (also known as ceroid lipofuscinosis neuronal 2; cln2).; Similarity: the predicted A. niger protein shows similarity to the lysosomal pepstatin insensitive protease (CLN2) of H. sapiens and other mammalians, which belong to the peptidase family S53.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; See PMID 9295267
An03g01030	Catalytic activity: 6-HDNO of A. oxidans catalyses the reaction (D)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: 6-HDNO of A. oxidans requires the covalently bound cofactor FAD.; Induction: 6-HDNO of A. oxidans is induced by nicotine.; Pathway: 6-HDNO of A. oxidans is involved in the degradation of nicotine.; Remark: coinduced in the presence of nicotine is a 6-hydroxy-L-nicotine-specific enzyme, 6-hydroxy-L-nicotine oxidase (6-HLNO), with FAD noncovalently bound to the apoprotein. the two enantiozymes are genetically unrelated.; Similarity: the predicted A. niger protein shows similarity to 6-hydroxy-D-nicotine oxidase (6-HDNO) of A. oxidans and other oxygen oxidoreductases that covalently bind FAD.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2115879; See PMID 2680607
An03g01050	Catalytic activity: endo-beta-1,4-glucanase of B. polymyxa endohydrolyses 1,4-beta-D-glucosidic linkages in cellulose.; Pathway: endo-beta-1,4-glucanase of B. polymyxa is involved in starch and sucrose metabolism.; Similarity: the predicted A. niger protein shows strong similarity to A. thaliana hypothetical proteins and is similar to endo-beta-1,4-glucanase of B. polymyxa which belongs to cellulase family A (family 5 of glycosyl hydrolases).; Title: similarity to endo-beta-1,4-glucanase -Bacillus polymyxa; See PMID 2307659
An03g01070	Title: questionable ORF
An03g01090	Golgi; Phenotype: disruption of HOC1 resulted in hypersensitivity to Calcofluor White and hygromycin B,phenotypes characteristic of defects in cell wall integrity and protein glycosylation, respectively.; Remark: HOC1 of S. cerevisiae is a component of the protein complex in the cis Golgi, that is involved in the elongation the mannan backbone of N-linked glycans of cell wall.; Remark: HOC1 of S. cerevisiae was identified by its ability to suppress the cell lysis phenotype of pkc1-371 cells, that are defective in a protein kinase C isozyme.; Similarity: the predicted A. niger protein shows similarity to HOC1 (homologous to OCH1) of S. cerevisiae,which is similar to alpha-1,6-mannosyltransferase (OCH1) of S. cerevisiae.; Title: similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 10037752
An03g01110	Domain: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus contains a 3-fold repeated sequence about 100 amino acids in length.; Function: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus is involved in the transport of carnitine or acylcarnitine from the cytosol to the mitochondrial matrix.; Localization: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus is an integral membrane protein of the inner mitochondrial membrane.; Similarity: the predicted A. niger protein shows strong similarity to mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus, which belongs to the mitochondrial carrier family.; Title: strong similarity to mitochondrial carnitine/acylcarnitine carrier protein - Rattus norvegicus; localisation:mitochondrion; See PMID 9032458
An03g01120	Catalytic activity: aspartate transaminase of S. cerevisiae catalyses the reaction L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Cofactor: aspartate transaminase requires pyridoxal-phosphate as a cofactor.; Remark: AAT2 of S. cerevisiae is also known as ASP5 and has a systematic name of YLR027C.; Remark: in eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.; Similarity: the predicted A. niger protein belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to cytosolic aspartate transaminase Aat2 - Saccharomyces cerevisiae; cytoplasm
An03g01130	Title: strong similarity to hypothetical protein encoded by An07g06330 - Aspergillus niger
An03g01140	Catalytic activity: A. phoenices oxalate decarboxylase (APOXD) catalyses the reaction oxalate = formate + CO2.; Remark: a vector containing the APOXD nucleic acid can be used to transform host cells for the recombinant production of the enzyme. the APOXD can be used for the degradation of oxalic acid in providing protection against oxalic acid toxicity. it is useful in combating and providing protection against plant pathogens that utilise oxalate to gain access to plant tissue or otherwise in the course of the pathogenesis of the disease. the APOXD gene is also useful as a selectable marker of transformed cells,for diagnostic assay of oxalate, and for production of the enzyme in plants. the product can also be used in diagnostic assays to quantify oxalate, e. g. in the diagnosis and treatment of patients with urinary tract disorders or hyperoxaluric syndromes.; Similarity: the predicted A. niger protein shows nearly identity to the protein sequence of patent WO9842827-A2 (AAW79948), which covers the A. phoenices oxalate decarboxylase (APOXD).; Title: strong similarity to oxalate decarboxylase (APOXD) from patent WO9842827-A2 - Aspergillus phoenicis; extracellular/secretion proteins
An03g01160	Remark: the present sequence is human epidermal protein-5 (HEPI) expressed in epidermal keratinocytes,dermal fibroblasts, and bronchial epithelium. this protein is derived from OVARNOT09 cDNA library. HEPI-5 shares 92% identity with mouse Ray protein expressed in skin. recombinant vectors comprising HEPI cDNA are introduced into host cells for protein expression. the HEPI proteins are useful for the treatment of epithelial disorders,including dyshidrotic eczema and scabies, cell proliferative disorders including actinic keratosis and arteriosclerosis, and autoimmune/inflammatory disorders like acquired immune deficiency syndrome (AIDS) and Addison's disease. pharmaceutical compositions comprising HEPI proteins are useful for treating disorders associated with altered HEPI expression.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of patent WO200006727-A2 (AAY44988), which covers the human epidermal protein-5.; Title: strong similarity to epidermal protein-5 HEPI - Homo sapiens
An03g01180	Remark: ORF5 is a protein located in a gene cluster flanking the NPKS (nonaketide polyketide synthase) gene,which is known to be required for lovastatin production. this portion of the gene cluster is referred to as the 'D4B segment'. increasing lovastatin, or monacolin J,production in a lovastatin-producing organism, comprises transforming the organism with a D4B segment, and expressing it (claimed). lovastatin will also be produced in non-lovastatin producing organisms (e. g. A. nidulans) by transformation with the D4B segment and the entire LovF gene. the methods are used to increase biosynthetic production of lovastatin (with an at least 5-fold increase) which is an anti-hypercholesterolaemic agent, and also has some anti-fungal activity. lovastatin inhibits the conversion of hydroxymethylglutarylcoenzyme A (HMG-CoA) into mevalonate by HMG-CoA reductase. the methods can also be used to increase production of monacolin J (claimed),which has anti-fungal activity.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence ORF5 of patent WO200006727-A2 (AAY44988); Title: strong similarity to ORF 5 protein from patent WO200037629-A2 - Aspergillus terreus
An03g01190	Title: strong similarity to hypothetical UDP-galactose 4-epimerase - Mesorhizobium loti
An03g01200	Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe
An03g01220	Remark: the protein sequence of patent GB2261878-A (AC# AAR35759) covers the apyrase enzyme (ATP diphosphohydrolase) of S. flexneri. the apyrase enzyme is associated with the virulence of all species of Shigella (e. g. S. flexneri, S. dysenteriae, S. sonnei, S. boydii) and related entero-invasive E. coli (EIEC) strains. the apyrase nucleotide sequence can be used in the detection of a virulence determinant in pathogenic bacteria.; Title: weak similarity to apyrase from patent GB2261878-A - Shigella flexneri
An03g01230	Function: biochemical analysis has shown that Csc25 of C. albicans activates the Ras/adenylyl cyclase pathway in S. cerevisiae at a rate two to three times faster than Cdc25 of S. cerevisiae, under the same conditions.; Similarity: similarity is restricted to carboxyterminus as usual for the proteins of the CDC25 family.; Similarity: the size of proteins of this family ranges from 309 residues (LTE1) to 1596 residues (sos).; Title: strong similarity to cell division cycle protein CDC25 - Candida albicans; See PMID 8477693
An03g01240	Function: the transporter for enterobactin (Enb1p) of S. cerevisiae specifically facilitates the uptake of catecholate-type siderophores.; Similarity: S. cerevisiae transporter for enterobactin (Enb1p), also known as YOL158c, and the predicted A. niger protein show strong similarity to the major facilitator superfamily.; Title: strong similarity to hypothetical siderophore-iron transporter for enterobactin Enb1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10831226
An03g01250	Title: questionable ORF
An03g01270	Title: weak similarity to hypothetical aminopeptidase SC8E4A.05 - Streptomyces coelicolor
An03g01280	Catalytic activity: glutaminyl-tRNA synthetase of S. cerevisiae catalyses the reaction ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).; Pathway: glutaminyl-tRNA synthetase activates L-glutamine for protein biosynthesis.; Remark: the amino-terminal extension of glutaminyl-tRNA synthetase of S. cerevisiae is dispensable for aminoacylation activity.; Remark: the patent match is against the translated human ORFX ORF2056 polynucleotide sequence (SEQ ID NO:4111) of patent WO200058473-A2 (AC# AAC76501).; Remark: the predicted A. niger protein may not be complete at the N-terminus, as its length is inbetween pro-and eucaryotic glutaminyl-tRNA synthetases.; Similarity: glutaminyl-tRNA synthetases of eucaryotes and procaryotes are highly conserved but differ in length due to longer eucaryotic N-terminal sequences.; Title: strong similarity to glutamine--tRNA ligase -Saccharomyces cerevisiae; See PMID 3301842; See PMID 8449914; See PMID 3301841
An03g01290	Similarity: the predicted A. niger protein shows strong similarity to several conserved hypothetical procaryotic proteins.; Title: strong similarity to hypothetical large secreted protein - Streptomyces coelicolor
An03g01300	Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea
An03g01310	Catalytic activity: CTP synthetase of S. cerevisiae catalyses the reaction ATP + UTP + NH(3) = ADP + phosphate + CTP.; Pathway: CTP synthetase catalyses the last reaction in the pyrimidine biosynthesis pathway.; Remark: in the presence of saturating concentrations of ATP and UTP, the URA7-encoded CTP synthetase exists as a tetramer.; Remark: phosphorylation of URA7-encoded CTP synthetase with protein kinase A stimulates its activity to 190%.; Remark: the CTP synthetases encoded by URA7 and URA8 of S. cerevisiae differ significantly with respect to several biochemical properties including turnover number,pH optimum, substrate dependences, and sensitivity to inhibition by CTP.; Similarity: the predicted A. niger protein is similar to both CTP synthetases (URA7 and URA8) of S. cerevisiae.; Title: strong similarity to CTP synthase Ura7 -Saccharomyces cerevisiae; cytoplasm; See PMID 7559626; See PMID 8121398; See PMID 8910520; See PMID 9632643; See PMID 1753946
An03g01320	Title: strong similarity to hypothetical protein mlr2056 - Mesorhizobium loti
An03g01350	Catalytic activity: alcohol dehydrogenase I (alcA) of A. nidulans catalyses the reaction alcohol + NAD(+) = aldehyde or ketone + NADH.; Cofactor: alcohol dehydrogenase I requires zinc 2+ for its activity.; Pathway: alcohol dehydrogenase I is involved in glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Regulation: alcohol dehydrogenase (ADH) I is induced by the transactivator alcR.; Remark: alcR itself is inducible by ethanol or acetaldehyde. alcR is subject to carbon catabolite repression and its expression is controlled by the negatively acting creA wide specificity gene. the repression of alcR is sufficient to explain the carbon catabolite repression of ADH I.; Remark: the patent match is against the A. niger adhA gene of patent WO8704464-A (AC# AAP70497).; Similarity: alcohol dehydrogenase I (alcA) of A. nidulans belongs to the zinc-containing alcohol dehydrogenase family.; Title: strong similarity to alcohol dehydrogenase alcA - Aspergillus nidulans; cytoplasm; See PMID 3158573; See PMID 3297923
An03g01360	Catalytic activity: low specificity threonine aldolase of S. cerevisiae catalyses the reaction L-allo-threonine or L-threonine = glycine + acetaldehyde.; Cofactor: low specificity threonine aldolase of S. cerevisiae needs pyridoxal phosphate as a cofactor.; Complex: GLY1 of S. cerevisiae exists as a homotetramer.; Pathway: threonine aldolase catalyses the last step in the glycine biosynthesis pathway.; Remark: GLY1 of S. cerevisiae has the systematic name of YEL046C.; Similarity: low specificity threonine aldolase of S. cerevisiae and the predicted A. niger protein belong to the threonine aldolase family.; Title: strong similarity to threonine aldolase Gly1 - Saccharomyces cerevisiae; See PMID 8132653; See PMID 9151955; See PMID 9163906
An03g01370	Title: strong similarity to hypothetical oxidoreductase of gene CC3685 - Caulobacter crescentus
An03g01390	Remark: the patent match is against the protein sequence of 6-hydroxynicotinic acid mono-oxygenase covered by patent JP09121864-A (AC# AAW10018).; Remark: the patented 6-hydroxynicotinic acid mono-oxygenase is useful for the industrial production of 2, 5-dihydroxypyridine.; Remark: the predicted A. niger protein shows strong similarity to several probable oxidoreductases of different procaryotic organisms.; Title: similarity to 6-hydroxynicotinic acid mono-oxygenase from patent JP09121864-A - Pseudomonas fluorescens
An03g01400	Similarity: the ORF shows strong similarity to another A. niger protein. The similarity between the two proteins, however, is restricted to a stretch of about 100 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g12070 - Aspergillus niger
An03g01410	Similarity: the ORF shows similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 100 amino acids.; Title: similarity to hypothetical protein encoded by An01g02950 - Aspergillus niger
An03g01420	Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An03g01430	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An03g01450	Remark: the patented DNA sequence encodes a Corynebacterium glutamicum membrane construction and membrane transport (MCT) protein. MCT nucleic acids and proteins are useful in the identification of microorganisms which can be used to produce fine chemicals, for modulating fine chemical production in C. glutamicum or related bacteria (e. g. Brevibacterium lactofermentum), the typing or identification of C. glutamicum or related bacteria, as reference points for mapping C. glutamicum genome, and as markers for transformation.; Similarity: the predicted A. niger protein and the translated DNA sequence (ID NO:513) of patent WO200100805-A2 (AC# AAF67999) belong to the major facilitator superfamily.; Similarity: the predicted A. niger protein is strongly similar to the putative membrane transporter encoded by SPAPB1E7. 08 of S. pombe.; Title: similarity to MCT protein from patent WO200100805-A2 - Corynebacterium glutamicum
An03g01460	Catalytic activity: gibberellin (GA) 7-oxidase oxidizes GA12-aldehyde to GA12 and GA14-aldehyde to GA14. they further metabolise GA12 to four products, two of which are monohydroxylated GA12.; Pathway: gibberellin 7-oxidase of C. maxima catalyses the last step in gibberellin biosynthesis.; Similarity: gibberellin 7-oxidase of C. maxima belongs to the superfamily of 1-aminocyclopropane-1-carboxylate oxidases.; Title: strong similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256
An03g01470	Remark: the genes for phthalate degradation are arranged in at least three transcriptional units in B. cepacia. the gene for phthalate dioxygenase reductase (ophA1) is present by itself, while the genes for an inactive transporter (ophD) and 4,5-dihydroxyphthalate decarboxylase (ophC) are linked and the genes for phthalate dioxygenase oxygenase (ophA2) and cis-phthalate dihydrodiol dehydrogenase (ophB) are linked.; Remark: uptake inhibition experiments show that 4-hydroxyphthalate, 4-chlorophthalate, 4-methylphthalate,and cinchomeronate compete for the phthalate permease of B. cepacia.; Similarity: the phthalate transporter (ophD) of B. cepacia belongs to the major facilitator superfamily.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; plasma membrane; See PMID 9851995; See PMID 10498738
An03g01480	Similarity: the predicted A. niger protein shows similarity to several hypothetical fungal proteins with an N-terminal C2H2 zinc finger domain and a conserved C-terminus.; Title: strong similarity to hypothetical C2H2 zinc finger protein - Schizosaccharomyces pombe
An03g01490	Remark: the patent match is against the translated DNA sequence 791 of patent WO0100843-A/791 (AC# AX064509).; Remark: the patent simply states that it covers C. glutamicum genes encoding metabolic pathway proteins.; Title: strong similarity to protein sequence 791 from patent WO0100843-A - Corynebacterium glutamicum
An03g01500	Title: strong similarity to hypothetical protein encoded by An11g08910 - Aspergillus niger
An03g01520	Catalytic activity: 12-oxophytodienoate reductase (opr) of L. esculentum catalyses the reaction 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + NADPH.; Cofactor: 12-oxophytodienoate reductase (opr) of L. esculentum is a flavin (FMN)-protein.; Pathway: L. esculentum 12-oxophytodienoate reductase is an enzyme of the octadecanoid signaling pathway.; Remark: photoreduction of the LeOPR-bound FMN resulted in the formation of a red, anionic semiquinone prior to the formation of the fully reduced flavin dihydroquinone. spectroscopic characterization of LeOPR revealed the formation of charge transfer complexes upon titration with para-substituted phenolic compounds, a distinctive feature of the enzymes of the OYE (Old Yellow Enzyme) family.; Similarity: 12-oxophytodienoate reductase (opr) of L. esculentum (LeOPR) and the predicted protein of A niger show strong similarity to NADH:flavin oxidoreductases.; Title: strong similarity to 12-oxophytodienoate reductase opr - Lycopersicon esculentum; See PMID 10574986
An03g01530	Catalytic activity: xanthine dehydrogenase (hxA) of A. nidulans catalyses the reaction xanthine + NAD(+) + H2O = urate + NADH.; Cofactor: xanthine dehydrogenase (hxA) of A. nidulans requires molybdenum as a cofactor.; Induction: the transcription of the hxA gene of A. nidulans is induced by the uric acid analogue 2-thiouric acid and repressed by ammonium. induction necessitates the product of the uaY regulatory gene.; Pathway: xanthine dehydrogenase (hxA) of A. nidulans is involved in the catabolism of adenine, urate and hypoxanthine.; Remark: the 5'-EST an_3264 of A. niger is highly similar to the nucleotide sequence of the ORF. this EST most likely encodes a C-terminal fragment of the A. niger xanthine dehydrogenase.; Title: strong similarity to xanthine dehydrogenase hxA - Aspergillus nidulans; See PMID 7876088
An03g01540	Catalytic activity: salicylate 1-hydroxylases catalyse the reaction salicylate + NAD(H) + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Cofactor: salicylate 1-hydroxylase requires the cofactor FAD.; Induction: nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate.; Pathway: NahG and NahW are involved in naphthalene and salicylate metabolism.; Remark: both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates,and chlorosalicylates.; Similarity: the predicted A. niger protein shows homology to two independent salicylate 1-hydroxylases (NahG and NahW) of P. stutzeri.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An03g01550	Catalytic activity: gluconate:NADP 5-oxidoreductase (GNO) of G. oxydans catalyses the reaction D-gluconate + NAD(P)(+) = 5-dehydro-D-gluconate + NAD(P)H.; Remark: GNO is involved in the nonphosphorylative,ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate.; Similarity: GNO of G. oxydans shows homology to members of the short-chain alcohol dehydrogenase family.; Specificity: GNO of G. oxydans is almost inactive with NAD as a cofactor and is very specific for the substrates gluconate and 5-ketogluconate.; Title: similarity to gluconate:NADP 5-oxidoreductase GNO - Gluconobacter oxydans [truncated ORF]; cytoplasm; See PMID 7751271; See PMID 7981120
An03g01560	Catalytic activity: phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O (acts also on monohydroxy-, monohalo-,monoamino- and monomethylphenols).; Cofactor: phenol 2-monooxygenase of T. cutaneum is a FAD flavoprotein.; Complex: phenol 2-monooxygenase of T. cutaneum is a homodimer.; Pathway: phenol 2-monooxygenase of T. cutaneum catalyzes the first step of phenol biodegradation.; Regulation: phenol 2-monooxygenase of T. cutaneum is inhibited by excess phenol.; Title: strong similarity to phenol 2-monooxygenase -Trichosporon cutaneum; See PMID 1429434
An03g01570	Function: the expression of spoVK in mother cells from B. subtilis is necessary for the completion of spore development.; Phenotype: mutations in spoVK of B. subtilis block the sporulation at a late stage.; Remark: manual closest BLASTP homologue: PIR:S16301.; Remark: spoVK of B. subtilis is also called spoVJ and belongs to the cbxx/cfxq superfamily, which members harbour conserved sequence motifs.; Title: similarity to stage V sporulation protein spoVK - Bacillus subtilis; See PMID 1732196; See PMID 1787791; See PMID 2514336; See PMID 6405008
An03g01590	Function: GAP1 of S. cerevisiae transports all naturally-occurring L-amino acids, GABA, ornithine,citrulline, some D-amino acids, and some toxic analogs.; Similarity: GAP1 of S. cerevisiae belongs to the major facilitator superfamily.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 8893857; See PMID 9171427; See PMID 9199164; See PMID 2194797
An03g01620	Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679
An03g01640	Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 40 amino acids.; Title: weak similarity to hypothetical protein encoded by An14g06170 - Aspergillus niger
An03g01650	Function: The mae1 gene encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 8750236
An03g01660	Function: APE3 of S. cerevisiae is a metallo (Zn2+) aminopeptidase activated by Co2+, and represents the major vacuolar aminopeptidase with preference for basic amino acids and proline.; Remark: APE3 of S. cerevisiae is also called APY1 or YBR286W.; Title: strong similarity to vacuolar aminopeptidase Y Ape3 - Saccharomyces cerevisiae; vacuole; See PMID 8175800; See PMID 8674980; See PMID 10551827; See PMID 10590462; See PMID 8175799
An03g01670	Title: strong similarity to hypothetical protein encoded by An10g00970 - Aspergillus niger
An03g01680	Similarity: 80% of the predicted protein is constituted by repetitive, low-complexity regions; these explain some BLASTP hits that cannot be considered significant.
An03g01690	Catalytic activity: dat of A. baumannii catalyzes the following reversible reaction: L-2,4-diaminobutyric acid + 2-ketoglutaric acid<-->L-glutamic acid + L-aspartic beta-semialdehyde.; Function: dat of A. baumannii participates in the synthesis of 1,3-diaminopropane, the only diamine found in this genus; however, the biological role, if one exists, of 1,3-diaminopropane synthesis is unknown.; Similarity: the predicted protein shows similarity also to other decarboxylases with different specificity.; Title: strong similarity to L-2,4-diaminobutyrate decarboxylase dat - Acinetobacter baumannii; See PMID 8772175; See PMID 9260954
An03g01700	Function: fumonisin esterases from E. spinifera can degrade fumonisin.; Remark: fumonisins, a class of mycotoxins, have cancer-promoting activity.; Title: strong similarity to fumonisin esterase BAA-ESP1 from patent WO9902703-A1 - Exophiala spinifera; See PMID 10441035
An03g01710	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:22769 from patent EP1033405-A2 - Arabidopsis thaliana
An03g01730	Title: weak similarity to galactitol utilization operon repressor encoded by ECs2893 - Escherichia coli
An03g01740	Title: similarity to hypothetical protein CAD70538.1 - Neurospora crassa
An03g01750	Function: Mst1 from A. muscaria is a monosaccharide transporter.; Induction: Mst1 from A. muscaria is constitutively expressed in fungal hyphae under all growth conditions.; Induction: in mycorrhizas and in hyphae from A. muscaria grown at higher monosaccharide concentrations increased the amount of AmMst1 transcript fourfold.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An03g01760	Function: ntf1 from S. pombe plays an important role in regulating the expression of the thiamine repressible gene nmt1.; Title: strong similarity to transcription factor ntf1p - Schizosaccharomyces pombe; nucleus; See PMID 8163491
An03g01770	Similarity: the ORF also shows strong similarity to the EST an_3410 from Aspergillus niger.; Title: strong similarity to EST an_3645 -Aspergillus niger
An03g01790	Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Similarity: the ORF encoded protein shows similarities to transporter proteins.; Title: strong similarity to transporter protein from patent WO0100804-A - Corynebacterium glutamicum [truncated ORF]; plasma membrane
An03g01800	Function: this bovine brain derived endogenous benzodiazepinoid or endozepine (EBZD) protein is a valium agonist binding to diazepam receptors.; Remark: at low dosage EBZD causes agitation and heightened awareness while at high dosage it causes sedation.; Similarity: the ORF shows similarity to acyl-coenzyme A-binding proteins, which is involved in membrane lipid transport/biogenesis by influencing acyl-CoA metabolism.; Title: strong similarity to brain polypeptide endogenous benzodiazepinoid EBZD from patent US5011777-A -Bos taurus; See PMID 1454809; See PMID 10331663
An03g01810	Remark: there are no further informations about the patent available.; Title: similarity to ORF5 protein from patent WO200037629-A2 - Aspergillus terreus
An03g01820	Phenotype: the disruption of the Nodulisporium melanin polyketide synthase pks1 gene results in a mel(-) phenotype.; Title: strong similarity to melanin polyketide synthase PKS - Nodulisporium sp.; See PMID 10628853
An03g01830	Title: strong similarity to hypothetical protein encoded by An12g05420 - Aspergillus niger
An03g01850	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:1406 from patent EP1033405-A2 - Arabidopsis thaliana
An03g01860	Catalytic activity: N-Carbamoylsarcosine + H2O = Sarcosine + CO2 + NH3.; Cofactor: one sulfate ion per subunit.; Complex: homotetramer.; Title: similarity to N-carbamoyl-sarcosine amidohydrolase CSHase from patent EP476670-A - Arthrobacter sp.; See PMID 8913306; See PMID 1381445
An03g01870	Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii
An03g01880	Function: an intermediate step in the Ubiquitylation reaction consist of a reversible thiolester binding between the C-terminal Glycin of Ubiquitin and an Cystein of the Ubiquitin conjugating enzyme.; Remark: the essentiell Cystein residue for a ubiquitin conjugating activity is conserved.; Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to ubiquitin conjugating enzyme SEQ ID NO:908 from patent EP1033405-A2 - Arabidopsis thaliana
An03g01890	Title: weak similarity to microtubule-associated protein tau - Mus musculus
An03g01910	Catalytic activity: ATP + N-Acetyl-L-glutamate = ADP + N-Acetyl-L-glutamate 5-phosphate.; Complex: Acetylglutamate kinase from N. crassa acetylglutamate kinase appears to be an octamer.; Function: Acetylglutamate kinase from N. crassa is a regulatory enzyme and has been shown to be feedback-inhibited by arginine.; Function: Acetylglutamate kinase is involved in arginine biosynthesis in N. crassa.; Localization: Acetylglutamate kinase from N. crassa has been shown to be a soluble matrix enzyme in mitochondria.; Title: strong similarity to N-acetylglutamate kinase AGK - Neurospora crassa; localisation:mitochondrion; See PMID 2420793; See PMID 2987210; See PMID 6251078
An03g01920	Remark: the human HSKM-B gene is expressed in human liver cancer tissue.; Remark: the matching coding sequence of patent WO200058473-A2 is identical to the sequence of the human HSKM-B.; Remark: there are no further informations about the patent available.; Title: similarity to human ORFX ORF2524 polypeptide sequence SEQ ID NO:5048 from patent WO200058473-A2 - Homo sapiens
An03g01940	Title: weak similarity to puromycin N-acetyl transferase pac - Streptomyces alboniger
An03g01950	Title: similarity to hypothetical conserved protein encoded by the gene CC3732 - Caulobacter crescentus
An03g01960	Title: questionable ORF
An03g02000	Function: nirA of A. nidulans encodes a transcription factor with a GAL4-type zinc finger domain.; Function: nirA of A. nidulans is a pathway-specific regulatory gene of nitrate assimilation.; Phenotype: mutations in nirA of A. nidulans affect the transcription levels of niiA and niaD (a nitrite and a nitrate reductase, respectively).; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: an alternate name for nitrate assimilation regulatory protein nirA is transcription factor nirA.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1538701; See PMID 1990284; See PMID 347305
An03g02030	Title: weak similarity to tissue plasminogen activator mutant 2K1 from patent WO8907146-A - Homo sapiens
An03g02040	Catalytic activity: S-Adenosyl-L-methionine + Phospholipid olefinic fatty acid = S-Adenosyl-L-homocysteine + Phospholipid cyclopropane fatty acid.; Function: the cyclopropane fatty acid (CFA) synthase of E. coli catalyzes the methylenation of the unsaturated moieties of phospholipids in a phospholipid bilayer.; Remark: overproduction of the CFA-synthase of E. coli causes abnormally high levels of CFA in membrane phospholipid but no discernable growth perturbation.; Title: strong similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli; See PMID 6325391; See PMID 7024727; See PMID 380648; See PMID 1445840
An03g02050	Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 100 amino acids.; Title: weak similarity to hypothetical protein encoded by An06g02100 - Aspergillus niger
An03g02060	Catalytic activity: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate = Pyrophosphate + Geranylgeranyl diphosphate.; Function: the albino-3 gene of N. crassa encodes the carotenoid biosynthetic enzyme geranylgeranyl-pyrophosphate synthetase.; Induction: the albino-3 gene is not expressed in the dark but its transcription is induced by blue light.; Remark: the synonym for albino-3 from N. crassa is al-3.; Title: strong similarity to geranylgeranyl pyrophosphate synthase albino-3 - Neurospora crassa; See PMID 1826006; See PMID 8350190
An03g02070	Title: similarity to hypothetical protein CAD11794.1 - Neurospora crassa
An03g02080	Catalytic activity: (1,4-alpha-D-Galacturonide)n + H2O = (1,4-alpha-D-Galacturonide)n-1 + D-Galacturonate.; Function: The enzyme pgaX from A. tubingensis has been characterized as an exopolygalacturonase [poly(1,4-alpha-D-galacturonide)galacturonohydrolase] that cleaves monomer units from the non-reducing end of the substrate molecule.; Induction: Expression of the pgaX gene from A. tubingensis is inducible with galacturonic acid and is subject to catabolite repression.; Title: strong similarity to exopolygalacturonase pgaX - Aspergillus tubingensis; extracellular/secretion proteins; See PMID 8856078
An03g02090	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also similarities to monooxygenases.; Title: similarity to protein fragment SEQ ID NO:50322 from patent EP1033405-A2 - Arabidopsis thaliana
An03g02100	Function: the lipase lipP from Pseudomonas shows high activity towards short-chain to medium-chain fatty acids and 1,3-positional specificity towards triolein.; Repression: the lipase lipP from Pseudomonas is strongly inhibited by zinc, cupric, ferric and mercury ions but is not affected by phenylmethylsulfonyl fluoride and bisnitrophenyl phosphate.; Similarity: lipP from Pseudomonas belongs to the 'GDXG' family of lipolytic enzymes.; Title: strong similarity to cold-adapted lipase lipP - Pseudomonas sp.; See PMID 9464382
An03g02110	Function: A ketoreductase is capable of reducing a variety of alpha-ketolactones, alpha-ketolactams and diketones.; Remark: The matched sequence of patent EP918090-A2 represents the putative ketoreductase of S. cerevisiae YDR541c.; Title: strong similarity to ketoreductase YDR541c from patent EP918090-A2 - Saccharomyces cerevisiae
An03g02120	Complex: Dal5 from S. cerevisiae is a component of the allantoate transport system.; Induction: the DAL5 gene is constitutively expressed in S. cerevisiae.; Remark: the Dal5 protein from S. cerevisiae is highly hydrophobic.; Remark: the synonym for Dal5 from S. cerevisiae is YLL055w.; Similarity: Dal5 from S. cerevisiae is a member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804; See PMID 10869563
An03g02130	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Remark: nahG from P. putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 8328809; See PMID 296054
An03g02140	Function: Uga3 of S. cerevisiae is required for GABA-dependent induction of GABA catabolic enzymes and a GABA-specific permease.; Remark: the synonym for Uga3 from S. cerevisiae is YDL170w.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 2109179; See PMID 10713424
An03g02150	Title: weak similarity to bacteriochlorophyll c synthase bchK - Chlorobium tepidum
An03g02160	Catalytic activity: UDPglucose = UDPgalactose.; Cofactor: NAD+.; Phenotype: the gal10 deletion mutant of S. cerevisiae is viable but cannot utilize galactose.; Remark: UDP-glucose 4-epimerase from Saccharomyces was inactivated both in vivo and in vitro (crude extracts) by L-arabinose or D-xylose.; Similarity: Gal10 from S. cerevisiaebelongs to the UDPglucose 4-epimerase family.; Title: similarity to UDP-glucose 4-epimerase Gal10 -Saccharomyces cerevisiae; See PMID 3333299; See PMID 6292668; See PMID 6987227
An03g02180	Remark: about the patent is no further information available.; Title: strong similarity to hydrophobic domain protein from patent WO200029448-A2 - Homo sapiens
An03g02190	Function: Sut1 from P. stipidis transports glucose and is also able to transport xylose and other monosaccharides.; Function: when SUT1 from P. stipidis is expressed in a S. cerevisiae hxt (hexose transporter) null mutant strain that is unable to take up monosaccharides, Sut1 restored growth on glucose.; Induction: in P. stipitis, transcription of SUT1 was strongly induced by glucose and was independent of the oxygen supply.; Similarity: Sut1 from P. stipidis show sequence similarities to the S. cerevisiae hexose transporter family and to monosaccharide transporters of other organisms.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane; See PMID 10048030
An03g02200	Title: weak similarity to hypothetical protein encoded by ORF of clone HEMBA1003229 - Homo sapiens
An03g02250	Title: weak similarity to antigenic protein t01A.aa BB001 from patent WO9859071-A1 - Borrelia burgdorferi
An03g02260	Function: the matched gene encode a C. glutamicum homeostasis and adaptation (HA) protein.; Remark: no further information about the patent is available.; Title: similarity to homeostasis and adaptation protein sequence SEQ ID NO:228 from patent WO200100842-A2 -Corynebacterium glutamicum
An03g02270	Complex: voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2,beta and delta subunits in a 1:1:1:1 ratio.; Function: the channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit.; Function: voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes,including muscle contraction, gene expression, cell motility, cell division and cell death.; Similarity: Fgalpha1S from R. catesbeiana belongs to the calcium channel alpha-1 subunits family.; Title: similarity to dihydropyridine receptor Fgalpha1S - Rana catesbeiana; plasma membrane; See PMID 9738021
An03g02280	Function: ssuD catalysis is absolutely dependent on FMNH(2) and oxygen.; Function: ssuD from E. coli encodes a reduced flavin mononucleotide-dependent alkanesulfonate monooxygenase; Function: ssuD from E. coli is responsible for the desulfonation of alkanesulfonates.; Function: the purified enzyme ssuD from E. coli catalyzed the conversion of pentanesulfonic acid to sulfite and pentaldehyde; Function: the purified enzyme ssuD from E. coli is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers.; Title: strong similarity to FMNH2-dependent aliphatic sulfonate monooxygenase ssuD - Escherichia coli; See PMID 10480865; See PMID 10506196
An03g02290	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to transcription factor Brn-2 - Rattus norvegicus
An03g02300	Catalytic activity: D-Threonine = Glycine + Acetaldehyde.; Function: the metal-activated pyridoxal enzyme from Arthrobacter is a low specificity D-threonine aldolase.; Remark: Mn2+ ion is an activator of the metal-activated pyridoxal enzyme from Arthrobacter.; Title: strong similarity to metal-activated pyridoxal enzyme D-threonine aldolase - Arthrobacter sp.; See PMID 9642221
An03g02310	Title: weak similarity to protein fragment SEQ ID NO:50343 from patent EP1033405-A2 - Arabidopsis thaliana
An03g02320	Catalytic activity: Phenol + NADPH + O2 = Catechol + NADP+ + H2O.; Cofactor: FAD flavoprotein.; Remark: phenol hydroxylases are involved in degradation of phenylalanine, toluene and gamma-hexachlorocyclohexane.; Remark: the phenol hydroxylase from T. cutaneum catalyzes the first step of phenol biodegradation.; Repression: the phenol hydroxylase from T. cutaneum is inhibited by excess phenol.; Similarity: the phenol hydroxylase from T. cutaneum belongs to the PHEA/TFDB family of FAD monooxygenases.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; cytoplasm; See PMID 9634698; See PMID 1429434
An03g02330	Catalytic activity: Urate + O2 + H2O = 5-hydroxyisourate + H(2)O(2).; Remark: 5-hydroxyisourate decompose to form allantoin.; Similarity: the matched protein belongs to the uricase family.; Title: strong similarity to urate oxidase from patent EP408461-A - Aspergillus flavus; peroxisome; See PMID 1339455
An03g02360	Title: weak similarity to spore-wall fungal hydrophobin dewA - Aspergillus nidulans
An03g02370	Title: weak similarity to rinder-pest virus nucleoprotein from patent JP05322898-A - Rinderpest virus
An03g02380	Phenotype: qde-2 mutants of N. crassa are defective in transgene-induced gene silencing.; Remark: in N. crassa QDE-2 is required for quelling.; Title: strong similarity to protein involved in post-transcriptional gene silencing Qde-2 - Neurospora crassa; nucleus; See PMID 9294193
An03g02400	Induction: the mRNA of dewA from E. nidulans accumulates preferentially during asexual sporulation.; Localization: dewA from E. nidulans is present in the spore wall, but not in the walls of germ tubes, hyphae or cells of the spore-producing conidiophore.; Phenotype: sporulating colonies of dewA null mutants wetted more rapidly with detergent solutions than did the wild type.; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: the synonym for dewA from E. nidulans is CAN4.; Similarity: dewA from E. nidulans belongs to the fungal hydrophobins, a group of small, hydrophobic cell wall proteins.; Title: strong similarity to spore-wall fungal hydrophobin dewA - Aspergillus nidulans; cell wall; See PMID 7651135
An03g02430	Catalytic activity: D-Mannitol + NAD = D-Mannose + NADH.; Function: The purified enzyme MtlD from P. fluorescens was shown to be a polyol dehydrogenase with a broad substrate spectrum oxidizing efficiently mannitol,sorbitol and arabitol.; Remark: EC 1. 1. 1. 255 (not yet present in EC catalogue).; Remark: The enzyme is specific for NAD and does not use NADP.; Title: strong similarity to mannitol dehydrogenase mtlD - Pseudomonas fluorescens; See PMID 9116029
An03g02480	Remark: the human PRO polypeptides have cytostatic activity.; Remark: there is no further information about the patent available.; Title: similarity to protein PRO1072 encoded by the sequence SEQ ID NO:303 from patent WO200053756-A2 - Homo sapiens
An03g02490	Catalytic activity: 2-Dehydro-3-deoxy-D-glucarate = Pyruvate + Tartronate semialdehyde.; Pathway: garL from E. coli catalizes the second step in the metabolism of d-galactarate.; Remark: garL from E. coli requires magnesium for activity.; Title: strong similarity to proliferation associated protein garL SEQ ID NO:257 from patent WO200044906-A2 -Escherichia coli; See PMID 10762278
An03g02500	Remark: C. pneumoniae causes respiratory disease such as pneumonia and bronchitis and is thought to be a contributing factor in heart disease, sarcoidosis,sinusitis, purulent otitis media, erythema nodosum or pharyngitis.; Remark: there is no further information about the patent available.; Title: similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae
An03g02510	Title: weak similarity to hypothetical protein CAD70818.1 - Neurospora crassa
An03g02525	Title: similarity to hypothetical proteinase encoded by 2SC3B6.04c - Streptomyces coelicolor
An03g02530	Title: similarity to hypothetical proteinase encoded by SCD8A.14c - Streptomyces coelicolor
An03g02540	Remark: the B. cinerea ABC transporter BcatrB protects the fungal pathogen against antimicrobial substances (phytoalexine) which are produced by a plant in response to infection by fungi or bacteria and helps to defend the plant by inhibiting the growth of invading microbes.; Similarity: the predicted A. niger protein contains two conserved ABC transporter domains (aa 103-264, 743-932,PF00005).; Title: strong similarity to ABC transporter BcatrB -Botrytis cinerea; See PMID 11310744; See PMID 11374155
An03g02550	Function: the C. aquaticum levodione reductase catalyzes regio- and stereoselective reduction of levodione ((6R)-2,2,6-Trimethyl-1,4-cyclohexanedione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol).; Induction: the C. aquaticum levodione reductase is strongly activated by monovalent cations like NH4+, K+ and Na+.; Similarity: the C. aquaticum levodione reductase posseses a consensus sequence (aa 41-229) of the very large family of short chain dehydrogenases/reductases (SDR), a familiy of NAD- or NADP-dependent oxidoreductases.; Title: similarity to levodione reductase lvr -Corynebacterium aquaticum; See PMID 10508066
An03g02560	Similarity: the ORF shows similarity to another A. niger protein. The other protein displays similarity to acetate regulatory DNA binding protein FacB of A. nidulans.; Title: strong similarity to hypothetical protein encoded by An15g04320 - Aspergillus niger
An03g02570	Phenotype: the expression of C. maltosa C450 52A3-a in S. cerevisiae resulted in a massive proliferation of the endoplasmatic reticulum.; Remark: expression of the C. maltosa C450 52A3-a in S. cerevisiae resulted in the formation of intact microsomal P-450 systems catalyzing the hydroxylation of n-hexadecane and lauric acid.; Similarity: the C. maltosa C450 52A3-a belong to the CYP52 multigene family occurring in the alkane-assimilating yeast C. maltosa.; Title: strong similarity to cytochrome P450 52A3-a -Candida maltosa; See PMID 1935996
An03g02580	Title: similarity to hypothetical protein SC4B10.33 - Streptomyces coelicolor
An03g02600	Function: S. pombe ptc3 encodes one of three protein phosphatase 2C homologs in the fission yeast genome participating in osmoregulation and cell shape control.; Title: weak similarity to protein phosphatase 2C tc3p - Schizosaccharomyces pombe
An03g02610	Title: strong similarity to hypothetical protein SPBC1604.01 - Schizosaccharomyces pombe
An03g02620	Title: strong similarity to protein fragment SEQ ID NO:34719 from patent EP1033405-A2 - Arabidopsis thaliana
An03g02630	Remark: the C. lindemuthianum homolog CIH1 is an oxidatively cross-linked proline-rich protein expressed only during the biotrophic stage of infection of Phaseolus vulgaris.; Title: similarity to hypothetical glycoprotein CIH1 - Colletotrichum lindemuthianum
An03g02640	Catalytic activity: ATP + {deoxyribonucleotide}(N) + {deoxyribonucleotide}(M) <=> AMP + diphosphate + {deoxyribonucleotide}(N+M).; Function: the C. albicans homolog CaLIG4 encodes an ATP-dependent DNA ligase.; Induction: C. albicans CaLIG4 is expressed in a cell cycle-dependent manner.; Remark: a putative sequencing error results in an frameshift.; Similarity: the C. albicans homolog shows significant similarity to ligase IV from both S. cerevisiae and humans.; Title: strong similarity to DNA ligase CaLIG4 -Candida albicans [putative frameshift]; putative frameshift
An03g02650	Function: the L. pneumophila homolog dotA belongs to the group of proteins required for phagosome formation during infection of alveolar macrophages. in addition to those Dot/Icm genes that encode the core transport apparatus, a subsets of genes are required for pore formation and modulation of phagosome trafficking.; Title: strong similarity to inhibitor of endosome-lysosome fusion dlpA - Legionella pneumophila; extracellular/secretion proteins
An03g02660	Title: strong similarity to hypothetical protein 17E5.30 - Neurospora crassa
An03g02670	Function: the S. cerevisiae homolog Fig4p is required for the mating process in response to direct cell-cell comunication.; Induction: S. cerevisiae FIG4 expression is induced by mating pheromone alpha-factor.; Title: strong similarity to hypothetical protein involved in mating Fig4 - Saccharomyces cerevisiae
An03g02680	Title: strong similarity to hypothetical protein encoded by An12g02060 - Aspergillus niger
An03g02690	Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An03g02700	Function: TRK2 encodes the low-affinity K+ transporter in S. cerevisiae.; Title: strong similarity to potassium transport protein Trk2 - Saccharomyces cerevisiae
An03g02720	Title: similarity to hypothetical myb-related protein YDR026c - Saccharomyces cerevisiae
An03g02750	Remark: the N. crassa homolog B11A5. 90 is significantly longer.; Title: strong similarity to hypothetical protein B11A5.90 - Neurospora crassa
An03g02770	Title: strong similarity to hypothetical protein YLR361c - Saccharomyces cerevisiae
An03g02780	Title: strong similarity to hypothetical protein 15E6.170 - Neurospora crassa
An03g02800	Title: strong similarity to EST an_2890 -Aspergillus niger
An03g02820	Function: the S. cerevisiae homolog Cvt17p is essential for degradation of subvacuolar vesicles which were derived from subcellular organells targeted for recycling in the vacuole under starvation conditions. CVT17 encodes a putative lipase, which conserved active-site serine motif is essential for this membrane lytic event.; Pathway: S. cerevisiae Cvt17p is involved in the cytoplasm to vacuole targeting (Cvt) pathway.; Title: strong similarity to hypothetical lipase Cvt17 - Saccharomyces cerevisiae
An03g02830	Catalytic activity: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO(2).; Function: S. cerevisiae Psd2p is involved in the synthesis of phosphatidylethanolamine and may be involved in regulation of intracellular trafficking of phosphatidylserine.; Golgi; Remark: the S. cerevisiae homolog Psd2p is significantly longer.; Title: strong similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae
An03g02840	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: the B. subtilis homolog fabG encodes a 3-oxoacyl-[acyl-carrier-protein] reductase and is involved in biosynthesis of fatty acids.; Pathway: first reduction step in the fatty acid biosynthesis pathway.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis
An03g02850	Title: strong similarity to hypothetical protein F2I11-120 - Arabidopsis thaliana
An03g02860	Phenotype: the S. cerevisiae SUR1 null mutant is viable, calcium sensitive at 37 degrees C on YPD but calcium tolerant at 26 degrees C, accumulates greatly reduced levels of several mannosylated sphingolipids.; Remark: alternate names for the S. cerevisiae SUR1 protein are BCL21, CSG1 and LPE15.; Remark: the S. cerevisiae SUR1 protein is thougt to be required for the mannosylation of inositolphosphorylceramide (IPC) to form mannosylinositolphosphorylceramide (MIPC).; Title: strong similarity to hypothetical protein EAA61879.1 - Aspergillus nidulans
An03g02870	Title: strong similarity to hypothetical transmembrane protein L2185.03 - Leishmania major
An03g02880	Similarity: the ORF shows strong similarity to another A. niger protein An08g04310. An08g04310, however,is much shorter than the ORF (271 compared to 688 amino acids).; Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa
An03g02890	Function: the S. pombe rad13 is a single-stranded endonuclease involved in excisioin repair of DNA damaged with UV-light, bulky adducts and cross-linking agents.; Remark: ORF 5'truncated due to end of contig.; Similarity: the S. pombe rad13 is similar to other members of the XPG/rad2 familiy.; Title: strong similarity to DNA repair protein rad13p - Schizosaccharomyces pombe [truncated ORF]; See PMID 8464724
An03g02900	Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to excision repair protein rad13p - Schizosaccharomyces pombe [truncated ORF]
An03g02920	Remark: A. nidulans cnxABC is a difunctional proteins with two catalytic domains, CNXA and CNXC.; Remark: the Aspergillus nidulans cnxABC locus encodes a single protein with two catalytic domains,required for synthesis of the precursor Z, an intermediate in molybdenum cofactor biosynthesis.; Similarity: the A. nidulans CNXA domain is similar to the E. coli moaA gene product, while CNXC is similar to the E. coli moaC product.; Title: strong similarity to molybdopterin cofactor biosynthetic protein cnxABC - Aspergillus nidulans; See PMID 9353296
An03g02930	Catalytic activity: the N. crassa amino-acid N-acetyltransferase converts Acetyl-CoA and L-glutamate to CoA and N-acetyl-L-glutamate.; Localization: the N. crassa amino-acid N-acetyltransferase is localised within the mitochondrial matrix where it is part of the Urea cycle and the metabolism of amino groups.; Remark: an alternative name for the N. crassa amino-acid N-acetyltransferase is acetylglutamate synthase.; Title: strong similarity to amino-acid N-acetyltransferase - Neurospora crassa; localisation:mitochondrion; See PMID 8939437
An03g02940	Function: it is proposed that TamA serve as a co-activator of AreA, the major nitrogen regulatory protein in A. nidulans.; Localization: the GFP-TamA fusion protein is predominantly localised to the nucleus in the presence and absence of ammonium.; Remark: the tamA gene of A. nidulans contains a putative zinc cluster motif which is not required for gene function.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: the tamA sequence shares significant homology with the UGA35/DAL81/DURL gene of S. cerevisiae.; Title: similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; nucleus; See PMID 8655534; See PMID 11459183
An03g02950	Title: similarity to hypothetical protein B16B8.350 - Neurospora crassa
An03g02960	Catalytic activity: the C. albicans beta-hexosamidase hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; Function: the beta-hexosamidase is involved in the glycoprotein degradation, aminosugar metabolism,glycosaminoglycan degradation and sphingoglycolipid metabolism.; Remark: a possible sequencing error occured at position 26746 leading to a stop codon, 1 base has been replaced with N.; Remark: an alterante name for C. albicans beta-hexosamidase is N-acetyl-beta-glucosamidase.; Title: strong similarity to beta-hexosamidase HEX1 -Candida albicans [putative sequencing error]; extracellular/secretion proteins; putative sequencing error; See PMID 9385137; See PMID 8169213
An03g02980	Function: thioredoxin is involved in oxidative stress response and redox regulation.; Localization: the S. cerevisiae TRX1 and TRX2 are located in the cytoplasm, while TRX3 is located in the mitochondrion.; Remark: A. nidulans thioredoxin is an intercellular disulphide-reducing enzyme which exhibits an unusual fluorescence emission spectrum, characterized by a high contribution of tyrosine residues.; Remark: the amino acid sequence of A. nidulans thioredoxin was determined by automated Edman degradation.; Similarity: the A. nidulans thioreduxin displays a sequence similarity of 45% to at least one of three thioredoxin homologues in S. cerevisiae TRX1, TRX2 and TRX3.; Title: strong similarity to thioredoxin -Aspergillus nidulans; cytoplasm; See PMID 1459127
An03g02990	Function: the K. lactis GNT1 protein plays a crucial role in the biosythesis of mannan chains to synthesise mannoproteins in the endoplasmatic reticulum.; Golgi; Remark: the genes for the Golgi apparatus N-acetylglucosaminyltransferase and the UDP-N-acetylglucosamine transporter are contiguous in Kluyveromyces lactis.; Title: similarity to alphaN-acetylglucosamine transferase GNT1 - Kluyveromyces lactis; See PMID 8650202; See PMID 10037760
An03g03000	Pathway: molybdopterin biosynthesis is an evolutionarily conserved pathway present in eubacteria,archaea and eukaryotes, including humans.; Phenotype: genetic deficiencies of enzymes involved in molybdopterin biosynthesis in humans lead to a severe and usually fatal disease due to a combined deficiency of the molybdoenzymes sulphite oxidase, xanthine dehydrogenase and aldehyde oxidase.; Remark: an alternative name for E. coli chlN is moeB.; Similarity: similarity is from the central region of the predicted A. niger protein to chlN of E. coli, which is 250 aa shorter.; Title: similarity to molybdopterin-converting factor activator chlN - Escherichia coli; See PMID 11135669; See PMID 11463785; See PMID 8514782
An03g03010	Remark: topoisomerase I from F. islandicum absolutely requires Mg2+ for activity, relaxes negatively but not positively supercoiled DNA and is inhibited by single-stranded M13 DNA and spermidine.; Title: similarity to hypothetical serine/threonine protein phosphatase topA - Fervidobacterium islandicum; See PMID 8241262
An03g03020	Remark: the impala element is 1280 nucleotides long and has inverted repeats of 27 bp.; Similarity: the translation of the impala ORF reveals strong similarities with the Tc1 from Caenorhabditis elegans and with the mariner element of Drosophila mauritiana.; Title: strong similarity to hypothetical impala transposase - Fusarium oxysporum; See PMID 7823909
An03g03030	Function: the KCL is part of the kinesin driven microtubule motor, walking towards the plus end and transporting vesicels.; Remark: the P. boryanum KLC represents a typical eukariotic protein in an eubacterial organism.; Title: strong similarity to cDNA kinesin light chain KLC - Plectonema boryanum; cytoplasm; See PMID 9212172
An03g03040	Remark: possible sequencing errors occured at position 5058, 1 base has been removed and 5090, producing a STOP codon, which was also corrected.; Remark: the A. niger Ant1 shows similarity, at the amino acid level, to the transposase of the Tc1/mariner class of DNA transposons.; Similarity: similarity is on the aa level between the predicted A. niger protein and A. niger Ant1 orf1 but not to adjacent orf's of Ant1 and not on the DNA level.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8552048
An03g03050	Remark: the predicted M. musculus protein seems to be involved in the early foregut differentiation of the mouse.; Similarity: the predicted A. niger protein contains 10 ankyrin repeats (PF00023) distributed over the whole length of the protein.; Title: strong similarity to cDNA gene trap ankyrin repeat containing protein Gtar - Mus musculus; See PMID 11165478
An03g03060	Remark: the ORF has an unusual exon/intron structure.; Similarity: the ORF shows strong similarity to another A. niger protein An12g06430. An12g06430 displays strong similarity to the reverse transcriptase of the LINE-like retrotransposon Tad1-1 of N. crassa.; Title: strong similarity to hypothetical protein encoded by An12g06430 - Aspergillus niger
An03g03070	Function: MLP-2 of R. norvegicus might be a novel member of the MRP family responsible for the excretion of organic anions.; Induction: MLP-2 of R. norvegicus is markedly induced by ligation of the bile duct in SD rat liver.; Remark: MLP-2 of R. norvegicus has the characteristics of ATP-binding cassette transporters.; Remark: MLP-2 of R. norvegicus is also called ABCC3,CMOAT2, MRP3, or MLP.; Remark: MLP-2 of R. norvegicus was expressed predominantly in the duodenum, jejunum, and colon.; Title: strong similarity to multidrug resistance-associated protein (MRP)-like protein-2 MLP-2 -Rattus norvegicus; See PMID 9614210; See PMID 10581366
An03g03090	Remark: the ORF has an unusual exon/intron structure.; Title: strong similarity to hypothetical protein encoded by An04g07640 - Aspergillus niger
An03g03100	Remark: the ORF has an unusual exon/intron structure.; Similarity: the ORF shows strong similarity to another A. niger protein An04g07840. An04g07840, however,is much longer than the ORF (518 compared to 160 amino acids).; Title: strong similarity to hypothetical protein encoded by An04g07840 - Aspergillus niger
An03g03110	Remark: Tnt1 of N. tabacum is capable of transposition.; Similarity: the similarity between the ORF and Tnt1 of N. tabacum is restricted to the C-terminal part of the two proteins.; Title: strong similarity to retroviral-like transposable element Tnt1 - Nicotiana tabacum; See PMID 2536143
An03g03120	Remark: the ORF is short in length (63 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An03g03130	Function: pabaA of A. fumigatus is essential for pathogenicity.; Pathway: pabaA of A. fumigatus catalyes a late step in the biosynthesis of folate.; Title: strong similarity to para aminobenzoic acid synthase pabaA - Aspergillus fumigatus; See PMID 10931287
An03g03270	Function: ankyrins link the spectrin-based membrane skeleton to the plasma membrane.; Remark: the mouse ankyrin seems aproximately 900 longer.; Title: similarity to ankyrin Ank1 - Mus musculus; See PMID 8486643
An03g03280	Remark: Ant1 is apparently present as a single copy in strain N402 of A. niger.; Similarity: at the amino acid level, to the transposase of the Tc1/mariner class of DNA transposons.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048
An03g03290	Remark: This sequence may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways.; Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 12343 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:12343 from patent EP1033405-A2 - Arabidopsis thaliana
An03g03300	Function: The N-glycosidase of P. dulcis acts by hydrolysing a beta-aspartyl glycosylamin bond of an asparagine-linkage type sugar chain of a glycopeptide.; Remark: the ORF encoded protein is almost identical to a peptide-N4-(N-acetyl-beta-D-glucosaminyl) asparaginase amidase N (pngN) of A. tubigensis which is wrongly assigned to A. niger (compare TREMBL:U96923_1 with PUBMED-ID: 9312552).; Title: similarity to almond N-glycosidase from patent EP676473-A2 - Prunus dulcis
An03g03310	Function: in N. crassa the tol protein is required for growth inhibition and cell death that occur when hyphae of opposite mating type fuse during vegetative growth.; Phenotype: point mutations in tol result in mutants that are wild type during vegetative growth and sexual reproduction, but that allow opposite mating-type individuals to form a vigorous heterokaryon.; Title: similarity to protein tol - Neurospora crassa; See PMID 9927450
An03g03320	Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Remark: the blastp matches are unspecific.
An03g03330	Catalytic activity: phenol 2-monooxygenase of T. beigelii catalyzes the reaction of Phenol + NADPH + O(2) <=> catechol + NADP(+) + H(2)O.; Title: similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434
An03g03340	Title: strong similarity to hypothetical protein encoded by An01g11840 - Aspergillus niger
An03g03350	Remark: HAP1 of S. cerevisiae has a systematic name of YLR256W.; Remark: HAP1 of S. cerevisiae was originally called CYP1 but this has now been assigned to a different gene.; Remark: the blastp matches of the ORF encoded protein is restricted to the fungal Zn(2)-Cys(6) binuclear cluster domain.; Similarity: the ORF encoded protein shows similarity to several fungal transcription factors.; Title: weak similarity to transcription activator Hap1 - Saccharomyces cerevisiae; nucleus
An03g03360	Function: the A. nidulans acuH gene is required for growth on acetate and long-chain fatty acids.; Function: the proposed function of the ACUH protein is the transport of acetylcarnitine molecules from the cytosol to the mitochondrial matrix.; Similarity: the A. nidulans acuH gene belongs to the mitochondrial carrier family.; Title: strong similarity to carnitine/acyl carnitine carrier acuH - Aspergillus nidulans
An03g03370	Similarity: the ORF shows strong similarity to the A. niger protein An03g03030. An03g03030, however, is much longer than the ORF.; Title: similarity to hypothetical protein CAD21095.1 - Neurospora crassa
An03g03390	Similarity: the ORF is nearly identical to another A. niger protein: An09g01480.; Title: strong similarity to hypothetical protein encoded by An09g01480 - Aspergillus niger
An03g03400	Title: strong similarity to hypothetical protein encoded by An09g01460 - Aspergillus niger
An03g03420	Similarity: the ORF encoded protein also shows similarity to hypothetical and known beta-lactamases (EC 3. 5. 2. 6) of different organisms.; Title: strong similarity to hypothetical protein PA0057 - Pseudomonas aeruginosa
An03g03430	Title: strong similarity to hypothetical protein encoded by An01g15030 - Aspergillus niger
An03g03440	Title: similarity to hypothetical protein encoded by An09g00290 - Aspergillus niger
An03g03450	Similarity: the ORF encoded protein also shows similarity to several hypothetical and known oxidoreductases.; Title: strong similarity to hypothetical alginate lyase BH0738 - Bacillus halodurans
An03g03460	Catalytic activity: D-arabinono-1,4-lactone oxidase catalyzes the reaction of D-arabinono-1,4-lactone + O(2) <=> D-erythro-ascorbate + H(2)O(2).; Catalytic activity: L-galactonolactone oxidase (1. 1. 3. 24) catalyzes the reaction of L-galactono-1,4-lactone + O(2) <=> L-ascorbate + H(2)O(2).; Function: D-erythroascorbic acid is an important antioxidant molecule in S. cerevisiae.; Remark: D-arabinono-1,4-lactone oxidase (1. 1. 3. 27) and protein YML086c are alternative names for L-galactonolactone oxidase in S. cerevisiae.; Title: strong similarity to L-galactonolactone oxidase Alo - Saccharomyces cerevisiae; See PMID 10094636
An03g03470	Function: the phrA gene plays a role in the genetic control of photoreactivation in Escherichia coli.; Function: the phrA gene product acts on lesions other than dimers, possibly pyrimidine (6-4) pyrimidone photoproducts.; Remark: the ORF encoded protein also shows similarity to hypothetical ABC transporter, ATP-binding proteins of different species.; Title: similarity to deoxyribodipyrimidine photolyase phrA - Escherichia coli; See PMID 7791009
An03g03480	Catalytic activity: UGDH catalyzes the reaction of UDP-glucose + 2 NAD(+) + H(2)O <=> UDP-glucuronate + 2 NADH.; Function: human UGDH is a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.; Title: similarity to UDP-glucose dehydrogenase UGDH - Homo sapiens; See PMID 9737970
An03g03500	Title: strong similarity to hypothetical protein CAD36989.1 - Neurospora crassa
An03g03510	Title: similarity to hypothetical protein encoded by An15g01720 - Aspergillus niger
An03g03520	Function: AM-toxin of A. alternata is a cyclic peptide host-specific toxin.; Phenotype: disruption of AM-toxin synthetase (AMT) resulted in toxin-minus mutants.; Similarity: AM-toxin synthetase of A. alternaty shows strong similarity to other fungal peptide synthetases.; Title: similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An03g03530	Similarity: the ORF shows strong similarity to the A. niger protein An16g04320.; Title: similarity to protein fragment SEQ ID NO:9681 from patent EP1033405-A2 - Arabidopsis thaliana
An03g03540	Function: iucB of E. coli functions as N epsilon-hydroxylysine:acetyl coenzyme A N epsilon-transacetylase.; Pathway: iucB of E. coli is involved in the aerobactin biosynthesis.; Title: similarity to aerobactin biosynthesis protein iucB - Escherichia coli; See PMID 8003107; See PMID 2935523
An03g03550	Catalytic activity: caiD of E. coli catalizes the reaction of D-carnitine to L-carnitine.; Pathway: carnitine metabolism.; Similarity: caiD of E. coli belongs to the enoyl-CoA hydratase/isomerase family.; Similarity: the ORF encoded protein also shows strong similarity to hypothetical and know enoyl-CoA hydratases (EC 4. 2. 1. 17).; Title: strong similarity to carnitine racemase caiD - Escherichia coli; See PMID 9748275
An03g03560	Function: ARN1, is involved in the transport of a specific class of ferrichromes, possessing anhydromevalonyl residues linked to N(delta)-ornithine (ARN).; Remark: YHL040C is the systematic name for ARN1.; Title: strong similarity to ferrichrome-type siderophore transporter Arn1 - Saccharomyces cerevisiae; See PMID 10802175
An03g03570	Remark: the ORF encoded protein also shows weak similarity to a human prenylcysteine carboxyl methyltransferase (by similarity) from patent W67730.; Title: weak similarity to hypothetical farnesyl cysteine carboxyl methyltransferase - Brucella melitensis
An03g03580	Title: strong similarity to hypothetical protein 65E11.100 - Neurospora crassa
An03g03590	Function: SPT10 of S. cerevisiae affects transcription at Ty1 elements, at PHO5,STE6 and ADH2.; Function: SPT10 of S. cerevisiae is a global transcriptional repressor of core promoter activity.; Function: SPT10 of S. cerevisiae is equired for normal levels of transcription and increased transcriptional regulation at a number of loci.; Remark: CRE1, SUD1 and YJL127C are alternative names for SPT10.; Title: strong similarity to regulator protein Spt10 - Saccharomyces cerevisiae; nucleus; See PMID 8138180; See PMID 8264536
An03g03600	Title: strong similarity to hypothetical DEAD box family helicase - Schizosaccharomyces pombe
An03g03620	Function: atrDp is involved in protection against cytotoxic compounds.; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082
An03g03640	Catalytic activity: enzyme of S. pombe catalyzes the reduction of quinone (coenzyme Q2) by sulfide.; Remark: questionable geneprediction at the aminoterminus might be caused by sequencing error.; Remark: the predicted protein is too long.; Title: strong similarity to mitochondrial sulfide dehydrogenase (coenzyme Q2) SPBC2G5.06c -Schizosaccharomyces pombe; localisation:mitochondrion
An03g03650	Similarity: shows only partial similarity to hypothetical protein.; Title: weak similarity to hypothetical protein YJR111c - Saccharomyces cerevisiae
An03g03660	Catalytic activity: converts oxidized glutathionine + NADPH into 2 glutathionine + NADP.; Function: enzyme of S. cerevisiae functions to maintain reduced glutathione levels at high levels.; Similarity: show strong similarity to other glutathione reductases.; Title: strong similarity to glutathione reductase Glr1 - Saccharomyces cerevisiae
An03g03680	Title: strong similarity to hypothetical protein encoded by An13g03400 - Aspergillus niger
An03g03690	Similarity: the ORF shows similarity to another A. niger protein: An03g03680. However, the two proteins differ in length and the similarity between the two proteins is restricted to a stretch of about 70 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g03680 - Aspergillus niger
An03g03700	Function: the function of the qutG and some other proteins of this family is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules.; Similarity: belongs to inositol monophosphatase family.; Title: strong similarity to inositol monophosphatase qutG - Aspergillus nidulans; See PMID 2175387
An03g03710	Function: both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate.; Function: quinate 5-dehydrogenase catalyses the conversion of quinate to 5-dehydroquinate.; Function: the functional integrity of the QUTB gene from A. nidulans (encoding quinate dehydrogenase) has been confirmed by transformation of a qutB mutant strain.; Function: this reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes.; Similarity: belongs to the shikimate and quinate dehydrogenases family.; Title: strong similarity to quinate 5-dehydrogenase qutB - Aspergillus nidulans; See PMID 2976880
An03g03720	Function: RAD14 plays an early role in nucleotide excision repair by recognizing and binding to damaged DNA.; Function: it binds specifically to damaged DNA.; Function: it is not required for transcription (although it contains zinc finger domains).; Function: it recognizes pyrimidine(6-4)pyrimidone photoproducts.; Title: strong similarity to nucleotide excision repair protein Rad14 - Saccharomyces cerevisiae; nucleus; See PMID 9268290
An03g03730	Catalytic activity: H2CO3 = CO2 + H2O; Function: carbonic anhydrases are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide.; Similarity: shows strong similarity to putative carbonic anhydrases of several organisms.; Title: strong similarity to hypothetical carbonic anhydrase SPBP8B7.05c - Schizosaccharomyces pombe
An03g03740	Function: O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety.; Function: beta-glucosidases of H. grisea and T. reesei are involved in cellulose utilization.; Localization: enzymes might be secreted.; Similarity: these fungal beta-glucosidases show significant homology to plant beta-glucosidases belonging to the beta-glucosidase A (BGA) family.; Title: strong similarity to beta-glucosidase bgl4 -Humicola grisea; See PMID 10101286
An03g03750	Function: abr2 is involved in conidial pigment biosynthesis in A. fumigatus.; Function: the enzymes that belong to this family include laccase that in fungi and plants oxidizes many different types of phenols and diamines, ascorbate oxidase.; Similarity: belongs to the multicopper oxidase family and shows strong similarity to laccases.; Title: strong similarity to brown 2 protein abr2 -Aspergillus fumigatus; See PMID 10515939
An03g03760	Similarity: blast hits contain a lot of repetitive sequences.; Similarity: the expression of a single neurofilament subunit in the lamprey that is most similar to the NF-M of higher vertebrates suggests that all three mammalian neurofilament subunits evolved from a single NF-M-like precursor.; Title: weak similarity to neurofilament subunit NF-180 - Petromyzon marinus; See PMID 7770000
An03g03770	Alternative name: usually ERG1.; Cofactor: squalene epoxidase contain a FAD binding domain.; Function: squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.; Similarity: squalene epoxidases seem to be highly variable at the aminoterminus because there exist several shorter and longer variants.; Title: strong similarity to squalene monooxygenase -Rattus norvegicus; endoplasmatic reticulum
An03g03780	Function: probably contains a nucleotidyltransferase domain and shows similarity to proteins containing such domains (ie. nuclear division protein TRF5 with DNA topoisomerase I-related function from S. cerevisiae).; Similarity: shows strong similarity at the aminoterminal part to several hypothetical proteins but is in general much longer.; Title: similarity to hypothetical protein SPAC821.04c - Schizosaccharomyces pombe
An03g03800	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: a splice site was detected upstream of the START codon.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An03g03810	Title: strong similarity to hypothetical conserved protein XF1745 - Xylella fastidiosa
An03g03820	Title: strong similarity to hypothetical protein SPCC320.08 - Schizosaccharomyces pombe
An03g03830	Similarity: most fungal proteins with similarities to the predicted protein are much shorter.; Similarity: shows similarity in the central part to Drosophila protein and several other hypothetical proteins.; Title: similarity to hypothetical protein CG9351 -Drosophila melanogaster
An03g03840	Title: similarity to hypothetical membrane protein YPR147c - Saccharomyces cerevisiae
An03g03850	Title: similarity to hypothetical protein encoded by G15G9.130 - Neurospora crassa
An03g03860	Catalytic activity: Inositol-1,4,5-trisphosphate 5-phosphatases convert D-myo-inositol 1,4,5-trisphosphate + H(2)O <=> D-myo-inositol 1,4-bisphosphate + phosphate.; Function: mouse INPP5P hydrolyzes various signaling molecules including the following: inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,phosphatidylinositol 4,5-bisphosphate, and phosphatidylinositol 3,4, 5-trisphosphate.; Localization: expression of the 115-kDa protein of M. musculus showed localization of enzyme activity to the membrane.; Localization: in mouse at least three isoforms of INPP5P derived from RNA splicing events exist, this allows differential distribution of the INPP5P activity between the membrane and cytosol of the cell.; Title: similarity to Inositol-1,4,5-trisphosphate 5-phosphatases INPP5P - Mus musculus; See PMID 9525932
An03g03870	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g03880	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Similarity: shows weak similarity to part of pilin from N. gonorrhoeae and immunoglobulin kappa-chain from H. sapiens.; Title: questionable ORF
An03g03890	Function: S. cerevisiae STE3 is a G protein-coupled receptor for the peptide pheromone a-factor.; Regulation: S. cerevisiae STE3 is endocytosed and recycled upon a-factor binding.; Regulation: in S. cerevisiae a-factor-induced phosphorylation of STE3 requires activation of the downstream G protein-directed signaling pathway.; Remark: alternative names for S. cerevisiae STE3 are DAF2 and YKL178c.; Title: similarity to peptide pheromone a-factor receptor Ste3 - Saccharomyces cerevisiae; plasma membrane; See PMID 10611235; See PMID 11062272; See PMID 3006051
An03g03900	Function: S. cerevisiae RIM1 is a nuclear gene encoding a mitochondrial single-stranded DNA-binding protein (SSB), which is required for activity of mitochondrial DNA-polymerase.; Remark: the predicted A. niger protein shows a pfam domain specific for single-stranded DNA-binding proteins.; Similarity: S. cerevisiae RIM1 contains three regions similar to C2H2 zinc fingers and an active cAMP-dependent protein kinase (cAPK) phosphorylation site.; Similarity: the predicted A. niger protein shows similarity to single-stranded DNA-binding proteins (including hypothetical) of different species.; Title: similarity to single-stranded DNA-binding protein Rim1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8367297; See PMID 9871116; See PMID 11087374
An03g03910	Remark: ORF might be questionable due to wrong gene prediction.; Title: weak similarity to creatinine amidohydrolase PSPS7 - Pseudomonas sp.; See PMID 7670196
An03g03920	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An03g03930	Function: contains a Sodium:galactoside symporter pfam-domain.; Similarity: shows similarity between central regions of the predicted A. niger protein and several neurofilaments (NF), this similarity might results a great deal from repetitive sequences.; Title: weak similarity to neurofilament NF-180 -Petromyzon marinus; See PMID 7770000
An03g03940	Function: S. cerevisiae SAC3 is involved in leucine permease transcriptional regulation, actin cytoskeleton organisation and mitosis.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and Sac3 of S. cerevisiae.; Title: similarity to potential regulator of leucine permease gene expression Sac3 - Saccharomyces cerevisiae; nucleus; See PMID 8799844; See PMID 10517330
An03g03960	Similarity: N-terminal region of predicted A. niger protein shows also similarity to N-terminal region of the hypothetical protein YDR124w from S. cerevisiae, which is 300 aa shorter.; Similarity: the ORF shows strong similarity to the A. niger protein An02g11860. The similarity between the two proteins, however, is restricted to a stretch of about 150 amino acids.; Title: strong similarity to hypothetical protein EAA61242.1 - Aspergillus nidulans
An03g03970	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g03980	Remark: blastp shows significant similarity (39% identity) between predicted A. niger protein and human secreted protein of patent WO9922243 but due to shortness of both peptides the probability is low (p=4,4).; Title: similarity to secreted protein from patent WO9922243 - Homo sapiens
An03g03990	Similarity: shows weak but significant similarity to part of the 5-aminolevulinate synthase of different species.; Title: weak similarity to 5-aminolevulinate synthase ALASN - Gallus gallus; See PMID 3005973
An03g04000	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g04010	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g04020	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g04030	Remark: blastp shows similarity (43% positives) between predicted A. niger protein and A. thaliana T6K12. 13 but due to shortness of both peptides the probability is low (p=6,4).; Similarity: similarity is from predicted A. niger protein to C-terminal region of A. .; Title: similarity to hypothetical protein T6K12.13 -Arabidopsis thaliana
An03g04040	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g04050	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF
An03g04060	Function: ATP binding cassette (ABC) protein superfamily members transport a variety of substances across biological membranes, including drugs, ions and peptides.; Function: the cadmium factor (YCF1) gene from S. cerevisiae is required for cadmium resistance.; Similarity: belongs to the ATP binding cassette (ABC) protein superfamily.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334; See PMID 9379898; See PMID 10529352
An03g04070	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An03g04080	Function: contains C2H2 type zinc-finger domains and might be involved in transcription.; Title: similarity to hypothetical protein YDR049w -Saccharomyces cerevisiae
An03g04090	Catalytic activity: MEK1 catalyzes the formation of peptidyl-serine-phosphate or peptidyl-threonine-phosphate using ATP.; Function: MEK1 is involved in meiosis and DNA recombination.; Function: Ser/Thr-kinases of the MEK1 type are involved in multiple signal transduction events leading to the phosphorylation and therafter nuclear translocation of MAP-kinases.; Remark: alternate names for S. cerevisiae MAP-kinase kinase/meiotic kinase MEK1 are MRE4, O6357 and YOR351c.; Title: similarity to protein kinase Mek1 -Saccharomyces cerevisiae; cytoplasm; deleted EC_number 2.7.1.37; See PMID 9552352; See PMID 1741279
An03g04100	Similarity: similarity is from predicted A. niger protein to N-terminal region of X. fastidiosa XF2713, which is 600 aa longer.; Title: similarity to hypothetical protein XF2713 -Xylella fastidiosa
An03g04110	Remark: information about rat ARP has not been published and is available from EMBL.; Similarity: similarity is from the predicted A. niger protein to N-terminal half of rat ARP.; Title: weak similarity to hypothetical atrophin-1 related protein ARP - Rattus norvegicus
An03g04120	Function: D. discoideum Amp1 is responsible for specially interacting with tyrosin-based sorting signals of integral membrane protein.; Function: the predicted A. niger protein shows similarity to several to clathrin coat assembly proteins of the AP50 superfamily, which mediate plasma membrane traffic.; Title: strong similarity to clathrin coat assembly protein Apm1 - Dictyostelium discoideum; See PMID 8996086; See PMID 10966473
An03g04130	Remark: ORF might be questionable as similarities to other proteins are either partial or due to repeats. .; Title: weak similarity to hypothetical protein SPAC3F10.07c - Schizosaccharomyces pombe
An03g04140	Function: NTA1 of S. cerevisiae is a component of a targeting complex in the N-end rule pathway of protein degradation.; Remark: alternative names of the S. cerevisiae protein are DEA1, J1742 and YJR062c.; Similarity: shows similarity to the N-terminal 2/3 of NTA1 only.; Title: strong similarity to N-terminal amidase Nta1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7744855
An03g04180	Complex: human USF2 forms a complex with USF1.; Remark: USF2 isoforms in H. sapiens result from alternative splicing.; Remark: in human the CAGCTG element is recognized by the USF1 / USF2 complex.; Similarity: shows similarity to proteins containing a helix-loop-helix DNA-binding domain, i. e. several centromerbinding proteins.; Title: similarity to upstream stimulatory factor of transcription USF2 - Homo sapiens; nucleus; See PMID 8576131; See PMID 11180124
An03g04190	Title: similarity to cellulase #2 from patent US2003036176-A1 - Xanthomonas campestris
An03g04210	Function: Sec8p and Sec15p of S. cerevisiae are components of a plasma membrane-associated 19. 5S particle,the exocyst, that may function downstream of Sec4p to control exocytosis.; Localization: depending on the analysed organism (S. cerevisiae, rat) 40-80% of the exocyst localises to the plasma membrane and the rest to the cytosole.; Similarity: shows similarity to the N-terminal half of sec8p only.; Title: similarity to component of the exocyst Sec8 -Saccharomyces cerevisiae; See PMID 10203793; See PMID 10973998
An03g04220	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.
An03g04230	Remark: human aminopeptidase P is a manganese(II)-dependent enzyme.; Similarity: shows strong similarity to aminopeptidases of different organisms.; Title: strong similarity to cytoplasmic form of aminopeptidase P - Homo sapiens; cytoplasm; See PMID 11106490
An03g04240	Similarity: very weak similarity to bacterial proteins.
An03g04250	Function: important targets of S. cerevisiae Kap122p is the complex of the large and small subunit (Toa1p and Toa2p, respectively) of the general transcription factor IIA (TFIIA).; Localization: S. cerevisiae Kap122p was localized both to the cytoplasm and the nucleus.; Similarity: by similarity rat lgl2 is a member of the karyopherin-beta family of nuclear import proteins.; Similarity: the predicted A. niger protein shows similarity to several karyopherin-beta proteins, among them S. cerevisiae KAP122 (formely PDR6).; Title: similarity to nuclear import protein LGL2 -Rattus norvegicus; See PMID 10525531; See PMID 10745026
An03g04260	Title: strong similarity to hypothetical protein CAD21410.1 - Neurospora crassa
An03g04270	Remark: ORF might be questionable; Similarity: very weak similarity to different bacterial proteins.
An03g04280	Function: Eukarya and Archaea exclusively use the pyroA pathway for pyridoxine synthesis.; Similarity: pyroA is highly conserved and belongs to the SNZ family.; Title: strong similarity to pyridoxine synthesis component pyroA - Aspergillus nidulans; See PMID 10438537
An03g04300	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An03g04310	Remark: blastp shows similarity (47% positives) between predicted A. niger protein and S. cerevisiae FUN14,but due to shortness of both peptides the probability is low (p=0,32).; Title: similarity to hypothetical protein Fun14 -Saccharomyces cerevisiae
An03g04320	Function: Cells lacking Orp2 undergo aberrant mitosis, indicating that Orp2 is involved in generating a checkpoint signal.; Function: Orp2 of S. pombe is required for DNA replication and interacts with the rate-limiting replication activator Cdc18.; Title: strong similarity to origin recognition complex protein orp2p - Schizosaccharomyces pombe; nucleus; See PMID 8552194
An03g04330	Function: the enzyme of S. cerevisiae catalyses the freely reversible interchange of an acetyl group between N-acetylornithine and glutamate.; Localization: The enzyme was localised to the mitochondrial matrix and was found to be a 57-kDa heterodimer consisting of subunits of 31 kDa and 26 kDa.; Remark: alternate gene name is ECM40.; Remark: alternate protein names are ornithine acetyltransferase; protein YM9916. 01c; protein YMR062c.; Similarity: shows strong similarity to putative glutamate n-acetyltransferase precursor of S. pombe.; Title: strong similarity to glutamate N-acetyltransferase Arg7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7705341
An03g04340	Function: the Sec61 protein is required for protein insertion in and translocation across the endoplasmic reticulum membrane.; Function: the Sec61 protein is required for protein translocation across the ER membrane in both yeast and mammals and is found in close association with polypeptides during their membrane transportation.; Similarity: Highly conserved, high sequence similarity to various species.; Title: strong similarity to ER membrane translocation facilitator Sec61 - Yarrowia lipolytica; endoplasmatic reticulum; See PMID 9427389
An03g04350	Remark: blast hits result from repetitive sequences.
An03g04360	Similarity: N-terminal part is similiar to central part of many different cyclins.; Title: strong similarity to hypothetical protein EAA61234.1 - Aspergillus nidulans
An03g04380	Alternative name: AUT1 or YNR007C.; Complex: Aut1p is subunit of the autophagy (Apg) conjugation complex reminiscent of the ubiquitin conjugation system, and is required for membrane recruitment of Apg7p and subsequent transport vesicle formation.; Function: Aut1p of S. cerevisiae is responsible for an unspecific bulk transpost of cytoplasmic proteins to the vacuole (CVT pathway) and is involved in autophagocytosis during starvation.; Title: strong similarity to autophagocytosis protein Aut1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9023185
An03g04390	Remark: blast hits result from repetitive sequences.; Title: weak similarity to S-layer protein -Clostridium thermocellum
An03g04400	Title: weak similarity to hypothetical protein encoded by An16g02860 - Aspergillus niger
An03g04410	Function: The enzyme of S. cerevisiae is involved in protein N-linked glycosylation. It catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.; Localization: Topological studies indicate that UDP-glucose:dolichyl-phosphate glucosyltransferase is a transmembrane protein that spans the membrane several times.; Localization: UDP-glucose:dolichyl-phosphate glucosyltransferase of S. cerevisiae is a transmembrane-bound enzyme of the endoplasmic reticulum.; Similarity: Highest similarity to as yet unpublished dolichyl-phosphate beta-glucosyltransferase of Ajellomyces capsulata; Title: strong similarity to UDP-glucose:dolichyl-phosphate glucosyltransferase Alg5 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8076653
An03g04420	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An03g04430	Similarity: similarity to the aminoterminal part of probable membrane protein YIL151c and probable purine nucleotide-binding protein YKR096w of S. cerevisiae.; Title: strong similarity to hypothetical protein EAA61229.1 - Aspergillus nidulans
An03g04440	Remark: truncated ORF due to end of contig.
An03g04460	Similarity: similarity to N-terminal part of hypothetical glutamate-ammonia ligase VC2746 from Vibrio cholerae.
An03g04470	Title: weak similarity to hypothetical zinc-finger protein 413R - Chilo iridescent virus
An03g04500	Title: similarity to hypothetical protein F16J13.50 - Arabidopsis thaliana
An03g04510	Catalytic activity: ADP-ribose + H(2)O <=> AMP + D-ribose 5-phosphate.; Function: YSA1 of S. cerevisiae hydrolyzes ADP-ribose to AMP and ribose-5-phosphate; hydrolyzes ADP-mannose, ADP-glucose, and diadenosine diphosphate.; Remark: YSA1 probably plays a role in preventing the accumulation of nucleoside diphosphate-sugar intermediates in S. cerevisiae.; Remark: alternate names = YBR111C, YBR0907.; Title: strong similarity to Nudix (nucleoside diphosphate) hydrolase Ysa1 - Saccharomyces cerevisiae; See PMID 10542272; See PMID 8810257
An03g04520	Catalytic activity: L-cysteine + cyanide <=> H(2)S + L-3-cyanoalanine.; Function: ILV-3 from S. cerevisiae is involved in that part of the biosynthesis of branched-chain amino acids (aa) through which pyruvate or alpha-ketobutyrate are converted into alpha-keto acids, precursors of valine,leucine or isoleucine.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945
An03g04530	Function: beta-PGM from L. lactis convertes beta-glucose 1-phosphate to glucose 6-phosphate.; Regulation: beta-PGM from L. lactis is maltose-inducible and glucose-repressible.; Remark: EC 5. 4. 2. 6; Title: similarity to beta-phosphoglucomutase beta-PGM - Lactococcus lactis; See PMID 9084169
An03g04540	Remark: shows weak similarity to aa 170-260 from 1000 aa ror-related receptor RTK of Discopyge ommata.
An03g04550	Function: RIT1 from S. cerevisiae encodes a phospho-ribosyl transferase that exclusively modifies the initiator tRNA (tRNAMet(i)) by the addition of a 2'-O-ribosyl phosphate group to Adenosine 64.; Function: Rit1 from S. cerevisiae is a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.; Title: strong similarity to initiator tRNA phosphoribosyl-transferase Rit1 - Saccharomyces cerevisiae; See PMID 10485288; See PMID 7954819
An03g04560	Catalytic activity: Alditol + NAD(P)(+) <=> aldose + NAD(P)H.; Function: the P. putida NADP(+)-dependent morphine dehydrogenase initiates morphine catabolism.; Remark: naloxone reductase is synonymous for morphine dehydrogenase.; Title: strong similarity to morphine dehydrogenase -Pseudomonas putida
An03g04570	Remark: alpha-actinin from D. discoideum is 200 aa longer.; Similarity: non-muscle alpha-actinin from D. discoideum is Calcium-sensitive and contains EF-hand structures.; Title: similarity to actin cross-linking protein alpha-actinin - Dictyostelium discoideum; cytoskeleton; See PMID 10413681
An03g04580	Title: similarity to hypothetical RNA binding protein CAB53728.1 - Schizosaccharomyces pombe
An03g04590	Function: HET-E from P. anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Function: disruption of the het-e locus does not impair the phenotype of strains but DNA hybridization analyses revealed that het-e may belong to a multigenic family.; Remark: HET-E from P. anserina contains a functional GTP-binding site and WD40 repeats.; Title: similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 12019224; See PMID 7557402
An03g04600	Complex: Ufd3p is an in vivo ligand of Cdc48p, an essential ATPase required for the cell cycle progression and the fusion of endoplasmic reticulum membranes.; Function: Ufd3p from S. cerevisiea is involved in the ubiquitin-dependent protein degradation.; Remark: UFD3 is synonymous for DOA1.; Title: strong similarity to WD-repeat protein required for ubiquitin-mediated proteolysis Doa1 -Saccharomyces cerevisiae; See PMID 8890162
An03g04610	Function: it is proposed that the human GlcNAc thyroid receptor NAGR1 triggers selective recycling of immature GlcNAc-bearing thyroglobulin molecules through the Golgi back to the apical membrane for further processing until maturation is achieved.; Remark: human TGR-CL10C is 100 aa shorter.; Remark: no literature available for human TGR-CL10C,it is described only in Patent number WO9219733-A/13,12-NOV-1992.; Title: similarity to thyroidal receptor for N-acetylglucosamine TGR-CL10C - Homo sapiens; See PMID 8088785
An03g04620	Title: strong similarity to mitochondrial ribosomal protein Cyt-21 - Neurospora crassa; localisation:mitochondrion
An03g04640	Similarity: weak similarity, due to central glycin and glutamic acid repeats, to retinitis pigmentosa GTPase regulator - Homo sapiens.
An03g04650	Title: similarity to hypothetical RNA binding protein - Schizosaccharomyces pombe
An03g04660	Similarity: shows similarity only in central part.; Title: weak similarity to hypothetical protein YGR165w - Saccharomyces cerevisiae
An03g04670	Title: similarity to response regulator mcs4p -Schizosaccharomyces pombe; See PMID 9136929
An03g04680	Title: strong similarity to hypothetical protein YDR090c - Saccharomyces cerevisiae
An03g04690	Complex: SH3 domain of Sho1p from S. cerevisiae interacts with Pbs2 (MAPKK).; Function: Sho1p from S. cerevisiae activates the HOG p38 MAPK-pathway during osmotic stress.; Remark: Yeast cdc42 GTPase and ste20 PAK-like kinase regulate Sho1-dependent activation of the hog1 MAPK pathway; Title: strong similarity to hypothetical osmosensor Sho1p - Candida utilis; plasma membrane; See PMID 10970855; See PMID 10980703; See PMID 11118628
An03g04700	Function: RO10 of N. crassa, as well as RO4 (actin-related protein ARP1, the most abundant subunit of dynactin), appears to be required for the stability of RO3 (p150Glued), the largest subunit of dynactin.; Similarity: RO10 from N. crassa is 200 aa shorter.; Title: strong similarity to RO10 - Neurospora crassa; See PMID 10361308
An03g04710	Title: strong similarity to hypothetical protein CAD21392.1 - Neurospora crassa
An03g04720	Function: production of cell wall-degrading enzymes (wall depolymerases) by plant pathogenic fungi is under catabolite (glucose) repression.; Title: strong similarity to serine threonine protein kinase SNF1 - Cochliobolus carbonum; See PMID 10662860
An03g04730	Similarity: only N-terminal 70 aa show similarity to C-terminus of krox-20 M. musculus.; Title: weak similarity to zinc-finger protein krox-20 - Mus musculus; See PMID 2496302
An03g04740	Similarity: FLU1 from C. albicans belongs to the major facilitator family.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353
An03g04750	Catalytic activity: Salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Remark: systematic name of salicylate hydroxylase is Salicylate 1-monooxygenase; Title: similarity to salicylate hydroxylase -Sphingomonas sp.; See PMID 10348858
An03g04760	Title: similarity to protein sequence #124 from patent WO200224865-A2 - Unclassified organism
An03g04770	Function: the forkhead-associated (FHA) domain is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Similarity: shows only partial similarity to forkhead-containing proteins.; Title: similarity to hypothetical protein CAD11383.1 - Neurospora crassa
An03g04780	Similarity: shows similarity at the aminoterminus to several proteins being mitochondrial NADH dehydrogenase subunit II which might be due to false gene prediction or the ORF might represent a pseudogene.; Title: weak similarity to hypothetical NADH dehydrogenase subunit II ND2 - Mesaspis moreleti
An03g04790	Function: Tom70 is implicated in the import of proteins from the cytosol into the mitochondria in S. cerevisiae and Neurospora crassa.; Function: it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.; Function: prominent examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase.; Function: the mitochondrial outer membrane plays a role in the stability of the mitochondrial genome in an obligate aerobe, probably through the import process.; Title: strong similarity to mitochondrial outer membrane protein Tom70 - Podospora anserina; localisation:mitochondrion; See PMID 9343397
An03g04800	Title: similarity to hypothetical protein YMR289w -Saccharomyces cerevisiae
An03g04810	Function: PRELI might be involved in maturation of human tissue.; Similarity: PRELI is almost identical to human PX19,that is also in the blast hits list and shows similarity to fungal hypothetical proteins like that resulting from the present ORF.; Title: weak similarity to protein of relevant evolutionary and lymphoid interest PRELI - Homo sapiens; See PMID 10784606
An03g04820	Similarity: the ORF also shows weak similarity at pos. 5 to 86 to several viral polyproteins.; Similarity: the ORF shows strong similarity to the A. niger protein An12g06110 along a stretch of about 80 amino acids.; Title: similarity to hypothetical protein encoded by An12g06110 - Aspergillus niger
An03g04840	Similarity: shows weak partial similarity to Hepatitis C virus sequences.
An03g04850	Similarity: shows weak similarity to decarboxylases of several species.; Title: weak similarity to p-coumaric acid decarboxylase pdc - Lactobacillus plantarum; See PMID 9143125
An03g04860	Function: NCE102 of S. cerevisiae may be a component of the non-classical export machinery.; Title: strong similarity to protein involved in non-classical protein export pathway Nce102 - Saccharomyces cerevisiae; See PMID 8655575
An03g04870	Function: contains a domain specific for Zinc-binding dehydrogenases.; Function: synthesis of the main nonaketide-derived skeleton was found to require the previously known iterative lovastatin nonaketide synthase (LNKS), plus at least one additional protein (LovC) that interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: the lovastatin biosynthesis cluster contains two type I polyketide synthase genes.; Similarity: shows similarity to Zinc-binding dehydrogenases.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An03g04880	Function: Ycf1p of S. cerevisiae selectively catalyzes the transport of glutathione-conjugated cadmium for detoxification in vacuoles.; Localization: Ycf1p is a vacuolar integral membrane protein.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 8990158
An03g04890	Catalytic activity: catalyzes the cyclization of farnesyl diphosphate to the tricyclic sesquiterpene hydrocarbon pentalenene.; Function: belongs to the family of phosphorus-oxygen lyases.; Function: pentalenene synthase is involved in the biosynthesis of pentalenolactone and related antibiotics.; Title: strong similarity to pentalenene synthase -Streptomyces sp.
An03g04900	Title: similarity to hypothetical protein CAB91439.2 - Neurospora crassa
An03g04910	Complex: adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles.; Function: adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes.; Remark: ORF might be questionable, especially at the aminoterminus (no similarity around start; large intron).; Similarity: adaptins seem to be conserved over all species.; Title: strong similarity to clathrin coat assembly protein AP19 - Camptotheca acuminata; intracellular transport vesicles; See PMID 9002613; See PMID 9653655
An03g04920	Phenotype: in S. cerevisiae the maf1 mutant shows a an altered intracellular localization of the Mod5p-I protein.; Remark: at about position 90 of the ORF encoded protein the Maf1p of S. cerevisiae has an extra 130 amino acids.; Title: similarity to Maf1 - Saccharomyces cerevisiae; See PMID 7732762
An03g04930	Title: similarity to hypothetical protein 12F11.80 -Neurospora crassa
An03g04940	Function: A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex in S. cerevisiae influences the membrane fusion stage of transport.; Localization: Erv41p of S. cerevisiae colocalizes to ER and Golgi membranes and exists in a detergent-soluble complex that was isolated by immunoprecipitation.; Remark: YML067C is the systematic name for ERV41.; Title: strong similarity to Erv41 - Saccharomyces cerevisiae; See PMID 11157978
An03g04950	Remark: the ORF is N-terminally truncated due to the contig end.; Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger [truncated ORF]
An03g04960	Function: when expressed in E. coli, DYRK2 catalyzes its autophosphorylation on tyrosine residues. DYRK2 phosphorylates histone H2B.; Similarity: the C-terminus of the predicted A. niger protein shows strong similarity to human protein kinase DYRK2, which belongs to a new family of protein kinases comprising at least seven mammalian isoforms (DYRK1A,DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A, and DYRK4B), the yeast homolog Yak1p, and the Drosophila kinase minibrain (MNB).; Title: similarity to protein kinase DYRK2 - Homo sapiens; See PMID 9748265
An03g04970	Function: cMrp of R. norvegicus is an organic anion and multidrug transporter.; Localization: rat cMrp is localized exclusively to the canalicular membrane domain of hepatocytes.; Similarity: cMrp of R. norvegicus is a member of the ABC transporter superfamily.; Title: strong similarity to canalicular multidrug resistance protein cMrp - Rattus norvegicus; plasma membrane; See PMID 8662992
An03g04980	Title: weak similarity to hypothetical protein YHL028w - Saccharomyces cerevisiae
An03g04990	Remark: the reserved name for YER002w of S. cerevisiae is NOP16, based on the suggestion, that NOP16 is a putative nucleolar protein.; Title: similarity to hypothetical protein YER002w -Saccharomyces cerevisiae
An03g05000	Title: similarity to human transmembrane protein HTMPN-73 from patent WO9961471-A2 - Homo sapiens; plasma membrane
An03g05010	Function: MNN9 isrequired for the synthesis of N-linked outer-chain mannan.; Golgi; Phenotype: disruption of MNN9 leads to phenotypic effects characteristic of cell wall defects including poor growth in liquid media and on solid media, formation of aggregates in liquid culture, osmotic sensitivity, aberrant hyphal formation, and increased sensitivity to lysis after treatment with beta-1,3-glucanase.; Remark: mannoproteins are a major component of the fungal cell wall and contain mannose in either O- or N-glycosidic linkages.; Title: strong similarity to cell wall biosynthesis protein MNN9 - Candida albicans; See PMID 10601199
An03g05020	Function: CACT transports acylcarnitines into mitochondria in exchange for free carnitine.; Pathway: CACT is essential for the fatty acid beta-oxidation pathway.; Title: strong similarity to carnitine/acylcarnitine translocase CACT - Homo sapiens; localisation:mitochondrion; See PMID 9837782; See PMID 11162577
An03g05030	Remark: N-terminally truncated due to contig border.
An03g05040	Title: similarity to EST an_2087 - Aspergillus niger
An03g05050	Function: the lvr gene product of C. aquaticum is an oxido-reductase catalyzing reduction of (6R)-2,2,6-trimethl-1,4-cyclohexanedione to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone.; Similarity: strong similarity to EST an_2379 Aspergillus niger.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066
An03g05060	Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 7520996; See PMID 8264542; See PMID 1878995; See PMID 2203793; See PMID 2249250
An03g05070	Catalytic activity: agmatine + H(2)O = putrescine + urea.; Function: the S. clavuligerus pah gene product is involved in clavulanic acid biosynthesis.; Title: strong similarity to proclavaminic acid amidino hydrolase pah - Streptomyces clavuligerus; See PMID 8088547; See PMID 8529893
An03g05080	Title: similarity to hypothetical protein YKL069w -Saccharomyces cerevisiae
An03g05090	Title: strong similarity to hypothetical protein associated with ferric reductase activity Utr1 -Saccharomyces cerevisiae
An03g05100	Complex: hRrp46 is part of the nuclear/nucleolar particle termed PM-Scl (polymyositis/scleroderma). the PM-Scl complex consists of 11 to 16 proteins.; Remark: the PM/Scl complex is the human counterpart of the yeast (S. cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases.; Remark: the exosome plays a major role in diverse RNA processing and degradation pathways.; Similarity: the predicted A. niger protein shows similarity to the human exosome component Rrp46 (hRrp46).; Title: similarity to exosome component Rrp46 - Homo sapiens; See PMID 11110791
An03g05110	Title: similarity to hypothetical protein BAB11562.1 - Arabidopsis thaliana
An03g05120	Remark: patentmatch against protein AX066343 Tremblnew.; Title: strong similarity to sequence 247 from patent WO0100804 - Corynebacterium glutamicum; plasma membrane
An03g05130	Title: similarity to hypothetical dihydrofolate reductase CAB16576.1 - Schizosaccharomyces pombe
An03g05140	Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 7500937; See PMID 8953776
An03g05150	Function: the R. graminis D-mandelate dehydrogenase is the first enzyme of the mandelate pathway and catalyses the NAD(+)-dependent oxidation of D(--)-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase - Rhodotorula graminis; See PMID 8343125; See PMID 8411179; See PMID 9639569; See PMID 1731758
An03g05160	Function: the FRE2 protein of S. cerevisiae is a plasma membrane bound ferric/cupric reductase and facilitates copper uptake.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 8164662; See PMID 9153234; See PMID 10341420; See PMID 11120744
An03g05170	Function: the H. sapiens srebp-1 protein act as a transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5'-atcaccccac-3') found in the flanking region of the ldrl gene as well as other genes.; Remark: the H. sapiens srebp-1 protein is attached to the membranes of the nuclear envelope and endoplasmic reticulum and is released into the nucleus upon proteolytic cleavage.; Title: similarity to sterol regulatory element binding protein-1 srebp-1 - Homo sapiens; nucleus
An03g05180	Title: weak similarity to hypothetical protein E2 -Human papillomavirus
An03g05190	Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH.; Remark: two isoforms of SDH1 from R. norvegicus are produced by use of alternative initiation codons in the same reading frame.; Title: strong similarity to sorbitol dehydrogenase SDH1 - Rattus norvegicus; See PMID 8223590; See PMID 8761460
An03g05200	Title: strong similarity to carboxypeptidase S1 -Penicillium janthinellum; See PMID 8224168
An03g05210	Catalytic activity: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).; Function: the E. californica bbe1 gene product is essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack.; Remark: The product of the reaction, (S)-scoulerine,is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.; Title: strong similarity to reticuline oxidase bbe1 - Eschscholzia californica; See PMID 7592663; See PMID 7764480; See PMID 9484487; See PMID 1946465
An03g05220	Title: similarity to hypothetical protein CAD70321.1 - Neurospora crassa
An03g05230	Remark: patentmatch against protein ORF 01ae12021orf5 protein AC W55192 Geneseqprot.; Title: weak similarity to protein from patent WO9737044-A1 - Helicobacter pylori
An03g05240	Title: similarity to myo-inositol dehydrogenase idhA - Sinorhizobium meliloti; See PMID 9802033
An03g05250	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Remark: alternative names are YJR152w, UREP1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804; See PMID 10869563
An03g05260	Catalytic activity: endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan.; Pathway: aminosugars metabolism.; Remark: by endo-splitting activity, the chitosanase hydrolysed chitosan to form chitosan oligomers with chitotriose, chitotetraose and chitopentaose as the major products. The enzyme hydrolyses chitohexaose to form chitotriose, while the chitopentaose and shorter oligomers remain intact.; Title: similarity to chitosanase csnA - Aspergillus oryzae; See PMID 11055393; See PMID 11388486
An03g05270	Title: weak similarity to hypothetical C-terminal region of hypothetical protein NMB0928 - Neisseria meningitidis
An03g05280	Title: weak similarity to hypothetical protein encoded by CG13918 - Drosophila melanogaster
An03g05290	Catalytic activity: successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating,and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.; Pathway: starch and sucrose metabolism.; Similarity: belongs to the hydrolases family 17.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; See PMID 2509432; See PMID 10935174
An03g05300	Catalytic activity: digallate + H2O = 2 Gallate.; Remark: tannase consists of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An03g05310	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: phenylalanine metabolism.; Remark: in this contig there is putative a second salicylate hydroxylase in ORF 25CK.; Remark: shows also strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An03g05320	Remark: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; See PMID 10978525
An03g05330	Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidases have wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Similarity: belongs to the beta-glucosidases.; Title: strong similarity to beta-glucosidase precursor BGLUC - Kluyveromyces marxianus; See PMID 2835179
An03g05340	Function: MAL13 regulates the coordinate transcription of structural mal1s (maltase) and agt1 (maltose permease) genes.; Remark: MAL13 contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain.; Remark: YGR288w, MAL1R, and MAL13 are synonymous names.; Title: similarity to maltose pathway regulatory protein Mal13 - Saccharomyces cerevisiae; See PMID 2278509; See PMID 2037232
An03g05360	Remark: also strong similarity to N. crassa mtr gene product patent WO9521263-A1.; Remark: the gene product of the mtr locus of Neurospora crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Remark: there is identity to EST SEQ ID NO:3943 from Aspergillus niger.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345
An03g05380	Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism.; Remark: cellulolytic proteins form a complex of enzymes that work together to depolymerize cellulose to the soluble products cellobiose and glucose. Fundamental studies on their molecular mechanisms have been facilitated by advances in molecular biology.; Title: similarity to cellulase FI-CMCase -Aspergillus aculeatus; See PMID 2249253; See PMID 7764343; See PMID 7764982; See PMID 10664848
An03g05420	Remark: strong similarity to human hNmrr protein SEQ ID NO:7 patent CN1269419-A.; Remark: the homologe is a human nitrogen metabolic repression regulator protein designated hNmrr. hNmrr is isolated from the human adrenal gland.; Title: strong similarity to nitrogen metabolic repression regulator protein hNmrr from patent CN1269419-A - Homo sapiens
An03g05430	Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913
An03g05440	Function: alb1 is required for conidial pigmentation and involved in dihydroxynaphthalene-melanin biosynthesi. in A. fumigatus.; Pathway: involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: the pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase alb1 - Aspergillus fumigatus
An03g05450	Remark: ABA2 cDNA encodes a chloroplast-imported protein of 72. 5 kDa, sharing similarities with different mono-oxigenases and oxidases of bacterial origin and having an ADP-binding fold and an FAD-binding domain. ABA2 protein, produced in Escherichia coli, exhibits in vitro zeaxanthin epoxidase activity. ABA2 opens the possibility to study the regulation of ABA biosynthesis and its cellular location.; Remark: abscisic acid (ABA) is a plant hormone which plays an important role in seed development and dormancy and in plant response to environmental stresses.; Title: similarity to zeaxanthin epoxidase ABA2 -Nicotiana plumbaginifolia; See PMID 8665840
An03g05460	Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: involved in aflatoxin biosynthetic pathway.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 2250647
An03g05470	Title: strong similarity to hypothetical protein SCD69.03 - Streptomyces coelicolor
An03g05480	Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: similarity to O-methyltransferase omtA -Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913
An03g05490	Catalytic activity: 3-oxoadipate + NAD+ or NADP+ = 2-maleylacetate + NADH or NADPH.; Pathway: phenylalanine metabolism; 1,4-dichlorobenzene degradation.; Remark: cloned Rhodococcus maleylacetate reductase was able to convert 2-chloromaleylacetate, an intermediate in the degradation of dichloroaromatic compounds,relatively fast and with reductive dehalogenation to maleylacetate.; Remark: maleylacetate reductases (EC 1. 3. 1. 32) have been shown to contribute not only to the bacterial catabolism of some usual aromatic compounds like quinol or resorcinol but also to the degradation of aromatic compounds carrying unusual substituents, such as halogen atoms or nitro groups.; Similarity: belongs to the alcohol dehydrogenase IV family.; Title: strong similarity to maleylacetate reductase macA - Rhodococcus opacus; See PMID 9657989
An03g05500	Remark: ORF13 A. terreu increases lovastatin or monacolin J production.; Remark: similarity to A. terreus ORF13 Zinc finger II protein patent WO200037629-A2.; Similarity: belongs to the GAL4 zinc binuclear cluster family.; Title: similarity to zinc finger II protein ORF13 from patent WO200037629-A2 - Aspergillus terreus
An03g05530	Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; can hydrolyze such linkages in beta-D-glucans that also contain 1,3-linkages.; Pathway: starch and sucrose metabolism; cellulose degradation.; Remark: strong similarity to Emericella desertoru EGIII-like cellulase patent WO9931255-A2.; Title: strong similarity to endo-beta-1,4-glucanase EGIII-like from patent WO9931255-A2 - Emericella desertoru
An03g05540	Remark: a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.; Remark: alternative name is YKR076w.; Title: strong similarity to hypothetical protein Ecm4 - Saccharomyces cerevisiae; See PMID 9335584
An03g05550	Title: weak similarity to hypothetical protein Rv3752c - Mycobacterium tuberculosis
An03g05560	Remark: Physarum polycephalum plasmodia survive adverse conditions by transforming into encysted cells called spherules. Spherulin 4 accumulates during spherulation.; Title: strong similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775
An03g05590	Remark: the transport of uracil into the yeast S. pombe is mediated by uracil permease, a specific co-transporter encoded by the FUR4 gene.; Remark: there is a striking similarity of DAL4 to the uracil permease component encoded by FUR4.; Similarity: belongs to the uracil/allantoin permase family of the major facilitator superfamily (MFS).; Title: strong similarity to uracil transport protein fur4p - Schizosaccharomyces pombe; See PMID 9730284
An03g05600	Remark: ankyrins form a connection from the actin cytoskeleton to the plasmamembrane.; Title: similarity to ankyrin G - Rattus norvegicus; See PMID 9744885
An03g05610	Title: similarity to hypothetical phage tail assembly like protein AAL21482.1 - Salmonella typhimurium
An03g05620	Title: strong similarity to hypothetical protein mll2018 - Mesorhizobium loti
An03g05630	Title: similarity to hypothetical protein CAD13748.1 - Ralstonia solanacearum
An03g05650	Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two protein is restricted to a stretch of about 300 amino acids.; Title: weak similarity to hypothetical protein encoded by An04g00590 - Aspergillus niger
An03g05660	Catalytic activity: 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Cofactor: Heme; Manganese.; Remark: This enzyme can also act as a peroxidase (EC 1. 11. 1. 7) for which several organic substances,especially ethanol, can act as a hydrogen donor. A manganese protein containing Mn(III) in the resting state,which also belongs here, is often called pseudocatalase. Enzymes from some microorganisms, such as Penicillium simplicissimum, which exhibit both catalase and peroxidase activity, have sometimes been referred to as catalase-peroxidase.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957
An03g05670	Alternative name: Veratryl alcohol oxidase.; Catalytic activity: An aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2); Remark: Oxidizes many primary alcohols containing an aromatic ring; best substrates are (2-naphthyl)-methanol and 3-methoxybenzyl alcohol.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774
An03g05680	Remark: the peptide synthetase mps is involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis.; Title: strong similarity to peptide synthase mps -Mycobacterium smegmatis; See PMID 10510238
An03g05690	Similarity: the ORF shows weak similarity to another A. niger protein: An03g05700. The similarity between the two proteins is restricted to a stretch of about 250 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g05700 - Aspergillus niger
An03g05700	Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 200 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g05690 - Aspergillus niger
An03g05710	Similarity: the similarity to CipA from Clostridium thermocellum is located in an highly repetetive sequence domain of CipA.; Title: similarity to S-layer protein CipA -Clostridium thermocellum; See PMID 8458832
An03g05720	Title: weak similarity to dnaK-type molecular chaperone HSP71.2 - Pisum sativum; See PMID 9207851
An03g05740	Similarity: similarity to cellulose synthase Y16099 Patentprot.; Title: similarity to cellulose synthase protein from patent JP11127867-A - Acetobacter xylinum
An03g05750	Function: the S. cerevisiae FLR1 gene product probable efflux transporter and confers resistance to the azole derivative fluconazole (FCZ).; Similarity: the S. cerevisiae FLR1 belongs to the major facilitator family (also known as the drug resistance translocasefamily), DHA14 subfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257
An03g05760	Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.; Function: the mam4 gene product modifies mating pheromone M-factor in h-cells modifies mating pheromone M-factor in h-cells.; Remark: mam4 mutation of S. pombe causes mating deficiency, the mam4 gene product shows methyltransferase activity.; Title: weak similarity to protein-S-isoprenylcysteine O-methyltransferase mam4p -Schizosaccharomyces pombe; See PMID 9032282
An03g05770	Title: similarity to Plasma membrane aquaporin 2b PAQ2b - Raphanus sativus; plasma membrane; See PMID 11216851
An03g05780	Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An03g05790	Function: the A. parasiticus O-methyltransferase catalyzes the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) in A. parasiticus is a multi-enzyme process controlled genetically by over 20 genes.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361
An03g05810	Function: the product of M. grisea pathogenicity gene pth11 is not required for appressorium morphogenesis but is involved in host surface recognition.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An03g05830	Remark: HOL1-1 single mutants show hypersensitivity to specific cations added to the growth medium, including Na+, Li+, Cs+, Be2+, guanidinium ion, and histidinol, but not K+, Rb+, Ca2+, or Mg2+.; Remark: mutations in the S. cerevisiae hol1 gene permit growth of His- cells on histidinol by enhancing the ability of cells to take up histidinol from the medium.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 2405251
An03g05840	Title: similarity to hypothetical puromycin N-acetyltransferase - Streptomyces lipmanii
An03g05850	Remark: ARG81 of S. cerevisiae is also known as ARGR2 (ARGRII) and has a systematic name of YML099C.; Title: weak similarity to hypothetical transcription factor Arg81 - Saccharomyces cerevisiae; See PMID 10688655
An03g05860	Function: the B. subtilis PNB carboxy-esterase (PNBCE) catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An03g05870	Title: similarity to hypothetical oxidoreductase PA5309 - Pseudomonas aeruginosa
An03g05880	Catalytic activity: a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Function: the A. oryzae amds gene product is required for utilization of acetamide or acetate plus beta-alanine as the sole carbon and nitrogen sources.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 10490592; See PMID 1840550
An03g05890	Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 9090059; See PMID 10869563
An03g05900	Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase, respectively.; Remark: there is another homologous regulatory gene from Aspergillus nidulans, nirA, which encodes a protein whose amino-terminal half has approximately 60% amino acid identity with NIT4 but whose carboxy terminus is completely different.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634; See PMID 1922075
An03g05910	Catalytic activity: Thiosulfate + Hydrogen cyanide = Sulfite + Thiocyanate.; Function: rhodanese is a detoxification enzyme for cyanide.; Title: strong similarity to hepatic rhodanese -Gallus gallus; See PMID 1953758; See PMID 2275748
An03g05930	Catalytic activity: acid phosphatases convert an orthophosphoric monoester + H2O <=> an alcohol + phosphate,but in addition catalyses transphosphorylations.; Remark: the acid phosphatase pho is also called orthophosphoric-monoester phosphohydrolase with acid optimum.; Similarity: the predicted ORF shows strong similarity to 3-phytase phyA of A. niger.; Title: strong similarity to acid phosphatase pho -Pichia pastoris; See PMID 7557473
An03g05940	Catalytic activity: gfa1 of S. cerevisiae catalyzes the formation of D-glucosamine-6-phosphate from the amido group of L-glutamine and fructose-6-phosphate: L-glutamine + D-fructose-6-phosphate <=> L-glutamate + D-glucosamine-6-phosphate.; Function: gfa1 of S. cerevisiae is involved in the first step of the hexosamine pathway required for biosynthesis of cell wall precursors.; Induction: the glutamine--fructose-6-phosphate amidotransferase activity of gfa1 from S. cerevisiae increases 1. 7-fold after alpha factor addition.; Induction: the promotor region of the S. cerevisiae gfa1 gene contains six repeats of the heptanucleotide TGAAACA, which was shown to be required for pheromone control of transcription.; Remark: glucosamine-6-phosphate is used in the biosynthesis of amino sugars of asparagine-linked oligosaccharide chains in glycoproteins.; Title: strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 -Saccharomyces cerevisiae; cytoplasm; See PMID 3301002
An03g05950	Function: the liz1 of S. pombe is a putative allantoate permease involved in ribonucleotide reductase activity during mitosis.; Phenotype: inactivation of ribonucleotide reductase causes liz1(-) cells in G2 to undergo an aberrant mitosis,resulting in chromosome missegregation and late mitotic arrest.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; See PMID 9950674
An03g05960	Catalytic activity: cEH of C. sp. acts on epoxides (alkene oxides, oxiranes) and arene oxides by converting an epoxide + H2O = a glycol.; Function: the cytosolic epoxide hydrolase cEH of C. sp. is involved in the catabolic degradation of epoxides.; Induction: cEH of C. sp is expressed constitutively at a low level, but can be induced by cyclohexane oxide and (+/-)-trans-1,2-dihydroxycyclohexane.; Title: strong similarity to epoxide hydrolase cEH -Corynebacterium sp.; See PMID 9578475
An03g05980	Function: facB of A. niger is a major regulatory gene involved in acetamide and acetate utilisation.; Function: the acetate regulatory gene facB of A. niger encodes a Zn(II)2-Cys6 transcriptional activator.; Phenotype: deletion of the facB gene of A. nidulans confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: the 180 C-terminal amino acids of the predicted ORF are not significantly homologues to the facB of A. niger.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; nucleus; See PMID 9197408
An03g05990	Function: A. parasiticus dmtA is an O-methyltransferase involved in aflatoxin biosynthesis.; Function: A. parasiticus dmtA is involved in the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: an alternative name for A. parasiticus dmtA is omtB.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10543813; See PMID 10806361
An03g06000	Catalytic activity: (R)-6-hydroxynicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Complex: A. oxidans 6-HDNO is a flavoprotein.; Function: A. oxidans 6-HDNO is involved in nicotine catabolism.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and A. oxidans 6-HDNO. .; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516
An03g06010	Function: A. alternata AMT is required to produce the cyclic peptide host-specific toxin, AM-toxin.; Similarity: similarity is from all of the predicted A. niger protein to all of A. alternata AMT, which is twice as long.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An03g06020	Catalytic activity: 4-carboxymuconolactone decarboxylase convert 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 4,5-dihydro-5-oxofuran-2-acetate + CO(2).; Function: A. calcoaceticus pcaC is involved in 3,4-dihydroxybenzoate-O(,2)-acetyl-Co A-succinate catabolism; Title: strong similarity to 4-carboxymuconolactone decarboxylase pcaC - Acinetobacter calcoaceticus
An03g06030	Title: weak similarity to flt-3 receptor agonist pMON32323.pep from patent WO9818923-A1 - Homo sapiens
An03g06040	Title: weak similarity to hypothetical protein T3F20.24 - Arabidopsis thaliana
An03g06060	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An03g06080	Function: S. cerevisiae UPC2 is a binucleate zinc cluster protein controlling expression of an anaerobic sterol transport system and DAN/TIR mannoproteins.; Induction: expression of S. cerevisiae UPC2 is induced both in anaerobic and cold-shocked cells.; Remark: the systematic name for S. cerevisiae UPC2 is YDR213w, an alternative name is MOX4.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; nucleus; See PMID 11238402
An03g06090	Function: overexpression of S. cerevisiae RTM1 confers resistance to the toxicity of molasses.; Remark: S. cerevisiae RTM1 is present in multiple copies and in variable locations in the genome and is always physically associated with SUC telomeric loci.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593
An03g06100	Remark: ORF 5'truncated due to end of contig.
An03g06120	Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An03g06130	Function: kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli.; Title: strong similarity to kinesin light chain KLC - Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346
An03g06140	Title: strong similarity to hypothetical protein encoded by 123A4.300 - Neurospora crassa
An03g06160	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An03g06210	Remark: the ORF also shows strong similarity to EST an_1824 of A. niger.; Title: similarity to hypothetical protein YGR273c -Saccharomyces cerevisiae
An03g06220	Similarity: the ORF encoded protein and Gel1p of A. fumigatus show similarity to the Gas/Phr/Epd protein families, which are involved in yeast morphogenesis.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; See PMID 10769178
An03g06230	Similarity: belongs to the GAL4 zinc binuclear cluster family.; Similarity: the ORF shows similarity to various transcription factors.; Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An03g06240	Remark: in fission yeast the protein has the following recognisable motifs present: a nuclear localization signal, a RING finger and helicase domains.; Similarity: belongs to the SNF2 protein family.; Title: strong similarity to DNA repair protein rad8p - Schizosaccharomyces pombe; See PMID 8290359
An03g06250	Remark: contrary to other members of the beta-transducin family, sequence conservation between the repeated units in het-e1 in Podospora anserina is very strong and the number of repeats is different in wild-type het-e alleles.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402
An03g06270	Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae
An03g06280	Remark: PTH11 from Magnaporthe grisea is about 300 amino acids longer.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea
An03g06290	Similarity: the ORF shows over a stretch of about 100 amino acids similarity to another A. niger protein,An11g08920.; Title: weak similarity to hypothetical protein encoded by An11g08920 - Aspergillus niger
An03g06300	Remark: the protein seems 80 amino acids too long.; Title: similarity to hypothetical protein Rv0272c -Mycobacterium tuberculosis
An03g06310	Catalytic activity: pectin + n H2O = n methanol + pectate.; Gene-ID: pmeA; Pathway: pentose and glucuronate interconversions; starch and sucrose metabolism.; Remark: on the basis of the results of affinity labeling of PME with sugar-specific lectins and the amino acid sequence data, it has been revealed that PME is a glycoprotein and the protein-bound glycans are oligosaccharides with a high mannose content.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Remark: this enzyme belongs to the group of pectic enzymes and catalyzes the hydrolysis of methyl ester groups of galactaronic acid residues of pectin.; See PMID 1937044; See PMID 2089377
An03g06320	Remark: Rhodococcus erythropolis TA421, a polychlorinated biphenyl and biphenyl degrader isolated from a termite ecosystem, has seven bphC genes expressing 2, 3-dihydroxybiphenyl dioxygenase activity.; Title: strong similarity to 2-hydroxyhepta-2,4-diene-1,7-dioateisomerase/5-carboxymeth yl-2-oxo-hex-3-ene-1,7-dioatedecarboxylase - Rhodobacter capsulatus; See PMID 9251216
An03g06330	Remark: the enzyme from Pseudomonas stutzeri catalyzes the extradiol ring cleavage of 2,3-dihydroxybiphenyl as a key enzyme in the biphenyl/PCB degradation pathway.; Title: strong similarity to 2,3-dihydroxybiphenyl-1,2-dioxygenase bphC - Pseudomonas stutzeri; See PMID 9095556
An03g06340	Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 90 amino acids.; Title: weak similarity to hypothetical protein encoded by An02g01320 - Aspergillus niger
An03g06350	Title: weak similarity to hypothetical protein YLR392c - Saccharomyces cerevisiae
An03g06360	Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: aminosugars metabolism.; Remark: chsC Aspergillus fumigatus is a Class III zymogen-type enzyme.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus; See PMID 8736545
An03g06370	Title: weak similarity to transcription activator Cha4 - Saccharomyces cerevisiae
An03g06380	Remark: FUM5 from Gibberella fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 11238987
An03g06390	Function: MhpA is involved in 3-(3-hydroxyphenyl)propionate degradation.; Remark: C. testosteroni MhpA degrades 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway.; Title: strong similarity to 3-(3-hydroxyphenyl)propionate hydroxylase MhpA - Comamonas testosteroni; See PMID 10537203
An03g06400	Remark: the positively acting amdA gene of Aspergillus nidulans encodes a protein with two C2H2 zinc-finger motifs and mediates omega amino acid induction of the amdS acetamidase and aciA.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 8119589; See PMID 9126617
An03g06410	Function: ERG25 of S. cerevisiae performs the first of three enzymatic steps required to remove the two C-4 methyl groups leading to ergosterol.; Pathway: ERG25 of S. cerevisae is involved in the ergosterol biosynthesis pathway.; Title: strong similarity to methyl sterol oxidase Erg25 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8663358; See PMID 9326581
An03g06420	Similarity: the predicted A. niger protein shows also weak similarity to the Pfam Acetyltransferase (GNAT) family signature.; Title: similarity to hypothetical protein encoded by An08g08870 - Aspergillus niger; See PMID 10692350
An03g06430	Catalytic activity: cinnamyl-alcohol dehydrogenases convert an Cinnamyl-alcohol+NADP(+) to an cinnamaldehyde + NADPH.; Function: M. sativa MsaCad1 catalyses the last step in the biosynthesis of the lignin monomers.; Induction: M. sativa MsaCad1 is wound-inducible, and the wound-responsiveness is modulated by salicylic acid.; Title: strong similarity to cinnamyl-alcohol dehydrogenase MsaCAD1 - Medicago sativa; See PMID 10092173; See PMID 10579494
An03g06440	Title: strong similarity to hypothetical protein EAA64120.1 - Aspergillus nidulans
An03g06450	Title: weak similarity to protein SEQ ID NO: 2310 from patent US6562958-B1 - Acinetobacter baumannii
An03g06460	Function: StcB from A. nidulans may be involved in the hydroxylation of averantin to form 5'-hydroxyaverantin,oxidation of averufin to 1-hydroxyversicolorone, and its oxidation to versiconal hemiacetal acetate.; Pathway: StcB from A. nidulans is involved in the sterigmatocystin biosynthesis.; Title: strong similarity to hypothetical sterigmatocystin biosynthesis p450 monooxygenase stcB -Aspergillus nidulans; See PMID 8643646
An03g06470	Title: weak similarity to MigA - Dictyostelium discoideum; See PMID 9307972
An03g06480	Remark: Steroid monooxygenase (smo) from R. rhodochrous is a Baeyer-Villigerase catalyzing the insertion of an oxygen atom between the C17- and C20-carbons of progesterone to produce testosterone.; Remark: the ORF coded protein shows also strong similarity to some hypothetical monooxygenases of secondary metabolism, MoxY Aspergillus parasiticus and StcW (Sterigmatocystin biosyntesis), Aspergillus nidulans.; Title: strong similarity to Steroid monooxygenase smo - Rhodococcus rhodochrous; See PMID 10467180
An03g06490	Title: similarity to heroin esterase her -Rhodococcus sp.; See PMID 9143135
An03g06500	Complex: N. plumbaginifolia ABA2 potentially uses FAD as cofactor.; Function: ABA2 from N. plumbaginifolia converts zeaxanthin into antheraxanthin and subsequently violaxanthin.; Function: N. plumbaginifolia ABA2 is involved in the epoxidation of zeaxanthin and plays an important role in resistance to stresses, seed development and dormancy.; Induction: N. plumbaginifolia ABA2 is upregulated in roots by drought stress.; Pathway: N. plumbaginifolia ABA2 is also involved in the xanthophyll cycle together with a yet unidentified de-epoxidase which converts violaxanthin into zeaxanthin.; Pathway: N. plumbaginifolia ABA2 is involed in the first step of the abscisic acid (ABA) biosynthesis pathway.; Remark: abscisic acid (ABA) is a plant hormone which plays an important role in seed development and dormancy and in plant response to environmental stresses.; Title: strong similarity to zeaxanthin epoxidase ABA2 - Nicotiana plumbaginifolia; See PMID 8665840
An03g06510	Function: S. cerevisiae UGA3 is required for 4-aminobutyric acid (GABA)-dependent induction of the UGA1,UGA2 and UGA4 genes which encode the two GABA catabolic enzymes and a GABA-specific permease, respectively,required for the utilization of GABA as a nitrogen source.; Remark: UGA3 from S. cerevisiae was judged closest manual homolog to the predicted A. niger protein even so it shows only an E-val of 0. 003, but the similarity extends over the total length of both proteins.; Similarity: UGA3 of S. cerevisiae contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain in the N-terminal region.; Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae; nucleus; See PMID 2109179; See PMID 7899074
An03g06520	Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 80 amino acids.; Title: similarity to hypothetical protein encoded by An08g08730 - Aspergillus niger
An03g06530	Remark: A. vitis ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate.; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; See PMID 7592429
An03g06540	Catalytic activity: arylsulfatases convert a phenol sulfate + H(2)O to a phenol + sulfate.; Remark: N. crassa ars-1 is expressed under conditions of sulfur limitation and is under coordinate control of the cys-3+ and scon+ regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685
An03g06550	Gene-ID: glaA;gla;amyG; Mapping: glaA from A. niger is mapped to chromosome VI (LG VI); see list from DSM, PUBMED 8041364.; Remark: a synonym for glaA is amyG.; Remark: glaA is alternative spliced and encodes preproglucoamylase G1 and preproglucoamylase G2.; extracellular/secretion proteins; See PMID 6204865; See PMID 6440004; See PMID 207655; See PMID 9649747; See PMID 1077246
An03g06560	Catalytic activity: lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Function: C. rugosa LIP2 is involved in glycerolipid metabolism and phospholipid degradation.; Remark: Candida rugosa is synonymous to Candida cylindracea.; Title: strong similarity to triacylglycerol lipase Lip2 - Candida rugosa; See PMID 8509417; See PMID 1610906
An03g06570	Remark: PAD1 confers resistance to cinnamic acid in S. cerevisiae.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae; See PMID 8181743
An03g06580	Function: in F. solani cutinase induction by cutin monomers is regulated by CTF1.; Similarity: similarity is between the Zn(2)-Cys(6) domain containing N-terminal half of the predicted A. niger protein and F. solani CTF1.; Similarity: the predicted A. niger protein contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to cutinase transcription factor 1 CTF1-beta - Fusarium solani; nucleus; See PMID 8132657
An03g06590	Catalytic activity: 4-hydroxybenzoate decarboxylases convert 4-hydroxybenzoate to phenol + CO(2).; Complex: the 4-hydroxybenzoate decarboxylase from C. hydroxybenzoicum had an apparent molecular mass of 350 kDa and consisted of six identical subunits of 57 kDa each.; Title: strong similarity to 4-hydroxybenzoate decarboxylase OHB1 - Clostridium hydroxybenzoicum; See PMID 7744052; See PMID 10438791
An03g06600	Similarity: similarity is between many probable Zinc-finger transcription factors and the N-terminal region of the predicted A. niger protein, which contains a BTB/POZ domain found in many Zn-finger transcription factors and required for homodimerisation.; Title: similarity to hypothetical protein KIAA0352 -Homo sapiens
An03g06620	Title: strong similarity to hypothetical protein aq_928 - Aquifex aeolicus; See PMID 9537320
An03g06630	Catalytic activity: lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Function: C. rugosa LIP1 is involved in glycerolipid metabolism and phospholipid degradation.; Remark: Candida rugosa is synonymous to Candida cylindracea.; Title: similarity to lipase LIP1 - Candida rugosa; See PMID 8509417; See PMID 1610906
An03g06640	Remark: blastp with the predicted A. niger protein only retrieves random hits to glycine and cysteine rich proteins.; Title: similarity to hypothetical protein encoded by An08g11130 - Aspergillus niger
An03g06650	Remark: S. coelicolor SC4G1. 04c is a putative integral membrane protein.; Title: similarity to hypothetical protein SC4G1.04c - Streptomyces coelicolor
An03g06660	Function: A. thaliana ptr2 imports dipeptides and tripeptides but not peptides four residues and higher.; Title: strong similarity to peptide transporter PTR2 - Arabidopsis thaliana; plasma membrane; See PMID 7919993
An03g06670	Function: S. cerevisiae MLP1 has been associated with the nuclear pore and is implicated in nuclear transport.; Title: weak similarity to myosin-like protein Mlp1 -Saccharomyces cerevisiae; See PMID 10085285
An03g06690	Catalytic activity: salicylate hydroxylases convert salicylate + NADH + O(2) to catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas stutzeri
An03g06700	Catalytic activity: cyclohexanone monooxygenases convert cyclohexanone + NADPH + O(2) to 6-hexanolide + NADP(+) + H(2)O.; Pathway: Acinetobacter chnB is involved in the cyclohexanol catabolic pathway.; Remark: Acinetobacter chnB is a flavoprotein (FAD) and acts on a number of different cyclic ketones.; Title: similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 3338974; See PMID 10543838
An03g06710	Function: human retSDR2 catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.; Title: similarity to retinal short-chain dehydrogenase/reductase retSDR2 - Homo sapiens; See PMID 10800688
An03g06720	Catalytic activity: cytochrome P-450s convert RH + reduced flavoprotein + O(2) to ROH + oxidized flavoprotein +H(2)O.; Function: D. melanogaster CYP4D2 is involved in the metabolism of insect hormones.; Similarity: D. melanogaster CYP4D2 belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P-450 CYP4D2 - Drosophila melanogaster; See PMID 8024706; See PMID 8676871
An03g06730	Function: P. denitrificans cobW might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: P. denitrificans cobW might take part in cobalamin biosynthesis.; Title: similarity to cobW - Pseudomonas denitrificans; See PMID 7765511; See PMID 1655697
An03g06740	Catalytic activity: 1,4-polygalacturonases convert (1,4-alpha-D-galacturonide)n + H(2)O to (1,4-alpha-D-galacturonide)n-1 + D-galacturonate.; Localization: C. carbonum PGX1 is an extracellular enzyme.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185
An03g06750	Similarity: the ORF shows strong similarity to another A. niger protein, An11g09050. An11g09050 is longer than the ORF (168 compared to 101 amino acids).; Title: similarity to hypothetical protein encoded by An11g09050 - Aspergillus niger
An03g06760	Title: strong similarity to hypothetical transcription regulator protein CAA91958.1 -Schizosaccharomyces pombe
An03g06790	Title: strong similarity to hypothetical protein B1D4.110 - Neurospora crassa
An03g06800	Title: strong similarity to hypothetical negative-acting regulatory protein qutR - Aspergillus nidulans
An03g06810	Similarity: the similarity of the predicted ORF to A. nidulans QUTA is restricted to its N-terminal half; additionally, the A. niger ORF is 108 amino acids shorter at the N-terminus.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276
An03g06820	Title: similarity to negative regulatory protein Hex2 - Saccharomyces cerevisiae; See PMID 1889400
An03g06830	Title: strong similarity to hypothetical protein B24P7.10 - Neurospora crassa
An03g06850	Title: strong similarity to hypothetical coiled-coil protein cgrA - Aspergillus nidulans
An03g06860	Title: strong similarity to hypothetical mitochondrial transport protein Arg11 - Saccharomyces cerevisiae
An03g06870	Catalytic activity: Cytidine + H(2)O <=> uridine + NH(3); Title: strong similarity to cytidine deaminase -Homo sapiens
An03g06880	Title: strong similarity to carboxypeptidase Y-sorting protein Pep1 - Saccharomyces cerevisiae
An03g06890	Title: similarity to hypothetical protein B16B8.140 - Neurospora crassa
An03g06900	Function: it is suggested that hSec10p is a component of the mammalian counterpart of the yeast exocyst complex essential for post-Golgi traffic.; Remark: SEC10 gene product is a member of the exocyst complex essential for exocytosis in the budding yeast S. cerevisiae.; Remark: alternate name in S. cerevisiae = YLR166C.; Title: strong similarity to exocytosis protein Sec10 - Saccharomyces cerevisiae; See PMID 8978675; See PMID 9119050; See PMID 9658167
An03g06910	Title: strong similarity to hypothetical 32.0k protein - Neurospora crassa
An03g06915	Title: weak similarity to hypothetical protein B14D6.5 - Neurospora crassa
An03g06920	Title: similarity to hypothetical protein CG5336 -Drosophila melanogaster
An03g06930	Function: checkpoint pathways act to arrest mitosis and prevent the attempted segregation of damaged or unreplicated DNA.; Function: rad17 function is not essential for growth, but is required for the function of the DNA structure-dependent checkpoints.; Function: rad17 gene product is a basic hydrophilic protein of 606 amino acids which contains five domains with sequence homology to replication factor C (RF-C)/activator 1 subunits.; Localization: rad17 is localized in the nucleus.; Similarity: no similarity at the aminoterminal part.; Title: similarity to protein involved in cell cycle control rad17p - Schizosaccharomyces pombe; nucleus; See PMID 8846774
An03g06940	Function: transports UDP-N-acetylglucosamine from the cytosol to the luminal side of the Golgi apparatus.; Golgi; Title: strong similarity to UPD-GlcNAc transporter MNN2-2 - Kluyveromyces lactis; See PMID 10037760
An03g06950	Function: cells with a disruption in the DNM1 gene showed mating response defects consistent with a delay in receptor-mediated endocytosis.; Function: during receptor-mediated endocytosis,Dnm1p acts after internalization, but before fusion with the vacuole.; Function: findings show that like mammalian dynamin,Dnm1p participates in endocytosis.; Title: strong similarity to dynamin-related protein Dnm1 - Saccharomyces cerevisiae; See PMID 7622557
An03g06960	Function: because the actin-binding protein ABP1p is associated with the cortical cytoskeleton of S. cerevisiae, it might be involved in the spatial organization of cell surface growth.; Function: in yeast, the cortical actin cytoskeleton seems to specify sites of growth of the cell surface.; Title: strong similarity to actin-binding protein Abp1 - Saccharomyces cerevisiae; cytoskeleton
An03g06970	Catalytic activity: AMP deaminase catalyzes the hydrolytic deamination of AMP into IMP.; Function: it contains three regions that are centered on residues which are proposed to play an important role in the catalytic mechanism.; Similarity: shows very strong similarity in the middle part of the protein to amp deaminase of several species.; Title: strong similarity to AMP deaminase Amd1 -Saccharomyces cerevisiae; See PMID 2690949
An03g06980	Remark: truncated ORF due to contig border.; Title: similarity to hypothetical protein B24M22.160 - Neurospora crassa [truncated ORF]
An04g00010	Remark: N-terminal truncated ORF due to end of contig.
An04g00020	Remark: Nup133p, functionally overlaps with the NUP145 gene product, Nup145p, and these proteins may be involved in maintaining the position of the NPC within the nuclear envelope.; Title: strong similarity to nuclear pore protein Nup133 - Saccharomyces cerevisiae; See PMID 7626806; See PMID 7813444; See PMID 7862658; See PMID 9049242
An04g00040	Catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].; Pathway: fatty acid biosynthesis (path 1).; Remark: the amino acid sequence of B. subtilis acyl carrier protein was obtained by sequencing the purified protein, and the sequence obtained strongly resembled that of E. coli acyl carrier protein, except that most of the protein retained the initiating methionine residue.; Similarity: belongs to the [acyl-carrier-protein] S-malonyltransferases.; Title: strong similarity to S-malonyltransferase fabD - Bacillus subtilis; See PMID 8759840
An04g00050	Remark: the predicted ORF shows homology to an A. niger EST an_2403.; Title: similarity to cancer associated protein sequence SEQ ID NO:919 from patent WO200055350-A1 - Homo sapiens
An04g00060	Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Remark: 19. 3 kD subunit of the respiratory chain complex I is binding to iron-sulphur cluster N-2.; Title: strong similarity to 19.3 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 10216160
An04g00070	Remark: alternative name is YJR002w.; Remark: depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites: A0, A1, and A2.; Title: strong similarity to component of the U3 small nucleolar ribonucleoprotein Mpp10 - Saccharomyces cerevisiae; See PMID 9315638; See PMID 9391061
An04g00080	Title: strong similarity to hypothetical membrane protein YNL024c - Saccharomyces cerevisiae
An04g00100	Remark: also strong similarity to EST an_2885 from Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC15E1.02c - Schizosaccharomyces pombe
An04g00110	Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Remark: also strong similarity to EST an_3610 Aspergillus niger.; Title: strong similarity to 21/29 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2137337
An04g00120	Remark: also strong similarity to Aspergillus niger EST SEQ ID NO:4000.; Remark: alternative name is YIL010w.; Remark: the ends of chromosomes in S. cerevisiae initiate a repressive chromatin structure that spreads internally and inhibits the transcription of nearby genes,a phenomenon termed telomeric silencing.; Similarity: to P. falciparum merozoite cap protein-1 and E. coli bacterioferritin comigratory protein.; Title: strong similarity to derepression of telomeric silencing protein Dot5 - Saccharomyces cerevisiae; See PMID 9755194
An04g00130	Remark: the identification of YAP19 S. cerevisiae supports the proposal that yeast cells also contain the Golgi-associated clathrin-assembly protein complex.; Title: strong similarity to intramitochondrial sorting protein YLR168c - Saccharomyces cerevisiae; See PMID 8373805
An04g00140	Catalytic activity: CTP + ethanolamine phosphate = pyrophosphate + CDPethanolamine.; Pathway: aminophosphonate metabolism; glycerolipid metabolism.; Remark: CTP:phosphoethanolamine cytidylyltransferase (ET) is a key regulatory enzyme in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis.; Similarity: belongs to the cytidylyltransferases.; Title: strong similarity to CTP:phosphoethanolamine cytidylyltransferase ET - Rattus norvegicus; See PMID 10493918
An04g00150	Remark: Grx5 plays a specially important role in protection against oxidative stress both during ordinary growth conditions and after externally induced damage. Grx5-deficient mutants are also sensitive to osmotic stress, which indicates a relationship between the two types of stress in yeast cells.; Remark: the synonyme for GRX5 is YPL059w.; Similarity: subfamily of yeast glutaredoxins (Grx3,Grx4, and Grx5) that differs from the first (Grx1 and Grx2) in containing a single cysteine residue at the putativeactive site.; Title: strong similarity to glutaredoxins Grx5 -Saccharomyces cerevisiae; See PMID 10567543
An04g00160	Remark: putatively involved in cell cycle-specific gene expression.; Remark: strong similarity to human receptor molecule (REC) encoded by Incyte clone 2022379 patent WO9957270-A2.; Title: strong similarity to receptor molecule REC from patent WO9957270-A2 - Homo sapiens
An04g00170	Function: the enzyme (EC:2. 5. 1-) catalyzes the prenylation of para-hydroxybenzoate.; Remark: coenzyme Q functions as a lipid-soluble electron carrier in eukaryotes. In S. cerevisiae, the enzymes responsible for the assembly of the polyisoprenoid side chain and subsequent transfer to para-hydroxybenzoate (PHB) are encoded by the nuclear genes COQ1 and COQ2,respectively. Disruption of the chromosomal COQ2 gene indicates the gene is not essential for viability, yet is required for PHB:polyprenyltransferase activity and respiratory function.; Title: strong similarity to para-hydroxybenzoate polyprenyltransferase Coq2 - Saccharomyces cerevisiae; See PMID 1740455
An04g00180	Title: similarity to hypothetical c-module-binding factor B21O8.50 - Neurospora crassa
An04g00190	Title: strong similarity to hypothetical protein CAD70403.1 - Neurospora crassa
An04g00200	Title: strong similarity to hypothetical membrane protein YIL157c - Saccharomyces cerevisiae
An04g00210	Remark: the intact MRP-L9 gene from S. cerevisiae is essential for mitochondrial function. YmL9 shows significant sequence similarities to Escherichia coli ribosomal protein L3 and related proteins from various organisms of all three natural kingdoms as well as photosynthetic organelles (cyanelles).; Title: strong similarity to ribosomal protein of the large subunit Yml9 - Saccharomyces cerevisiae; See PMID 1597181; See PMID 2060626; See PMID 3060376
An04g00220	Catalytic activity: acetyl-CoA + peptide = CoA + Nalpha-acetylpeptide.; Remark: N alpha-Acetylation is catalyzed by N alpha-acetyltransferases, which transfer acetyl groups from acetyl coenzyme A to the N termini of most eukaryotic proteins co-translationally.; Remark: acetylates N-terminal alanine, serine,methionine and glutamate residues in a number of peptides and proteins, including beta-endorphin, corticotropins and alpha-melanotropin.; Title: strong similarity to methionine-N-acetyltransferase Nat2 - Saccharomyces cerevisiae; See PMID 8175741
An04g00230	Protein sequence is in conflict with the conceptual translation; Remark: putative sequencing error at position 23746 exchanging an G to T to generate an ATG.; Remark: the NUC-2 protein from N. crassa appears to sense the availability of phosphate and transmits the signal downstream to the regulatory pathway.; Title: strong similarity to ankyrin repeat protein Nuc-2 - Neurospora crassa [putative sequencing error]; putative sequencing error; See PMID 8917314
An04g00240	Title: weak similarity to basic fibroblast growth factor precursor bFGF - Homo sapiens
An04g00250	Similarity: unspecific to serine/threonine-rich proteins.; Title: strong similarity to hypothetical protein CAD70464.1 - Neurospora crassa
An04g00270	Title: strong similarity to hypothetical protein CAD70410.1 - Neurospora crassa
An04g00300	Title: weak similarity to ascites sialoglycoprotein 1 - Rattus norvegicus
An04g00310	Title: questionable ORF
An04g00340	Function: in S. cerevisiae ITR2 is a permease importing inositol from the external environment into the cytosol.; Similarity: in S. cerevisiae ITR1 is strongly related to ITR2, an inositol permease which is expressed at much lower levels.; Title: strong similarity to myo-inositol transport protein Itr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 7768846; See PMID 7934871; See PMID 2040626
An04g00350	Similarity: partial similarity to probable serine carboxypeptidase of Caenorhabditis elegans.
An04g00360	Complex: in S. cerevisiae, Sec13p participates,together with the Sar1, Sec31, Sec23, and Sec24 proteins to the formation of the COPII coat, necessary for COPII vesicles formation.; Function: in S. cerevisiae, Sec13p is a cytoplasmic protein involved in release of transport vesicles from the ER. Sec13p is also involved in a post-Golgi trafficking step specific for the General Aminoacid Permease Gap1p.; Remark: identical to A. niger EST EMBLEST:BE759088.; Title: strong similarity to transport vesicle formation protein Sec13 - Saccharomyces cerevisiae; cytoplasm; See PMID 9568718
An04g00370	Function: in Y. lipolytica, PEX20 is required for both the oligomerization of thiolase in the cytosol and its targeting to the peroxisome.; Localization: in Y. lipolytica, PEX20 is mostly cytosolic, whereas 4-8% is associated with peroxisomes.; Remark: peroxins are proteins required for peroxisome assembly.; Title: similarity to peroxin protein PEX20 -Yarrowia lipolytica; cytoplasm; See PMID 9679140; See PMID 11042200
An04g00380	Remark: only partial weak similaritiy to some metallopeptidases (proteinases) of H. influenca.
An04g00390	Complex: in S. cerevisiae, SFH1 interacts functionally and physically with an essential Snf2p paralog in a novel nucleosome-restructuring complex called RSC (for remodels the structure of chromatin).; Function: in S. cerevisiae, SFH1 is required for cell cycle progression.; Remark: in S. cerevisiae, SFH1 is a phosphoprotein which phosphorilation is regulated during the cell cycle.; Similarity: the protein shows strong homology to the functionally and evolutionary significant 200 amino acids long domain of the SNF5 regulatory protein family.; Title: strong similarity to chromatin-remodeling complex protein Sfh1 - Saccharomyces cerevisiae; nucleus; See PMID 9154831
An04g00400	Function: in S. cerevisiae, the WHI2 gene is important for cell cycle arrest upon nutrient exhaustion,as WHI2 mutants continue to divide and become abnormally small when nutrients are depleted.; Title: similarity to growth regulation protein Whi2 - Saccharomyces cerevisiae; See PMID 3900284; See PMID 9202462; See PMID 2204679
An04g00410	Catalytic activity: in R. norvegicus, the enzyme releases a n-terminal dipeptide from a peptide of four or more residues, with broad specificity.; Cofactor: in R. norvegicus, the protein binds one zinc ion.; Function: in R. norvegicus, the enzyme is a cytosoline-type peptidase that cleaves arg-arg-beta-naphthylamide with pH optimum of 9. 0; Regulation: in R. norvegicus, the enzyme is inhibited by thiol reagents.; Title: strong similarity to dipeptidyl peptidase III - Rattus norvegicus; See PMID 9425109; See PMID 10387075
An04g00420	Remark: involvement of Ca2+ in enhancing the MAP kinase signaling cascade in plants.; Similarity: also similarities to membrane-associated form of proteophosphoglycans.; Title: similarity to MAP kinase homolog WCK-1 -Triticum aestivum
An04g00430	Catalytic activity: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.; Cofactor: Pyridoxal-phosphate.; Function: BAT2 of S. cerevisiae catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine, and it is involved in cell cycle regulation.; Localization: in S. cerevisiae BAT2 is located in the cytoplasm.; Regulation: in S. cerevisiae BAT2 is highly expressed during stationary phase and down-regulated during logarithmic phase of growth.; Similarity: in S. cerevisiae a close homologue,called BAT1, exhert the same catalytic activity in the mitochondria.; Title: strong similarity to branched-chain-amino-acid aminotransferase Bat2 -Saccharomyces cerevisiae; cytoplasm; See PMID 8702755; See PMID 8798704
An04g00440	Remark: partial weak similarities to IgE-binding protein of mouse and carbohydrate binding proteins of other organisms.
An04g00470	Title: weak similarity to hypothetical protein C50F2.2 - Caenorhabditis elegans
An04g00480	Similarity: the ORF encoded protein shows interesting domain homology (bZIP domain) to the regulator of cyclic peptide biosynthesis and pathogenicity TOXEp from Cochliobolus carbonum, Pubmed 9894916.; Title: similarity to hypothetical protein CAE85614.1 - Neurospora crassa
An04g00490	Complex: the S. cerevisiae casein kinase II (CKII) is composed of two catalytic and two regulatory subunits encoded by the CKA1, CKA2, CKB1, and CKB2 genes.; Function: the S. cerevisiae Ckb1 protein is component of the casein kinase II (CKII). Analysis of null and conditional alleles of the CKII encoding genes identifies a requirement for CKII in at least four biological processes: flocculation (which may reflect an effect on gene expression), cell cycle progression, cell polarity, and ion homeostasis.; Remark: alternate name for S. cerevisiae Ckb1: YGL019W.; Title: strong similarity to regulator subunit of the casein kinase II Ckb1 - Saccharomyces cerevisiae; See PMID 9427841; See PMID 10515937; See PMID 7737972
An04g00500	Function: PrnA is a transcriptional activator of the fungal binuclear zinc cluster type that mediates proline induction of genes involved in proline utilization as sole nitrogen and/or carbon source in A. nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; nucleus; See PMID 9622360; See PMID 10788322
An04g00510	Title: similarity to hypothetical protein CAA99769.1 - Caenorhabditis elegans
An04g00520	Title: similarity to hypothetical protein EAA60488.1 - Aspergillus nidulans
An04g00530	Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 2664423; See PMID 7590163
An04g00550	Title: strong similarity to EST an_1834 -Aspergillus niger
An04g00560	Title: similarity to steroid membrane binding protein from patent WO9810291-A1 - Homo sapiens
An04g00570	Function: the S. cerevisiae Nop77 protein is required for ribosomal RNA biogenesis. It probably functions in the processing of 27S rRNA to produce mature 25S rRNA and interacts with Nop1.; Remark: alternate names for S. cerevisiae Nop77: Nop4 or YPL043W.; Title: strong similarity to essential nucleolar protein Nop77 - Saccharomyces cerevisiae; nucleus; See PMID 8039506
An04g00580	Function:the S. pombe Swi10 is involved in termination of copy-synthesis during mating-type switching. It is also involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with S. pombe Rad16 it forms an endonuclease that specifically degrades single-stranded DNA.; Similarity: the ORF encoded protein and S. pombe Swi10 belong to the ERCC1/RAD10/SWI10 family.; Title: strong similarity to mating-type switching protein swi10p - Schizosaccharomyces pombe; nucleus; See PMID 9207030; See PMID 1475195
An04g00590	Title: weak similarity to nuclear matrix transcription factor MINT - Mus musculus
An04g00600	Function: S. cerevisiae Lag1 protein is involved in the yeast cell aging process. A deletion of the LAG1 gene results in a pronounced increase (approximately 50%) in mean and in maximum life span.; Remark: alternate name for S. cerevisiae Lag1: YKL008c.; Title: strong similarity to hypothetical ER-to-Golgi transporter Lag1 - Saccharomyces cerevisiae; See PMID 8195187
An04g00610	Catalytic activity: (R)-mevalonate + CoA + 2 NADP(+) <=> (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: the 3-Hydroxy-3-methylglutaryl-CoA reductase (Hmg1) from Schizosaccharomyces pombe is the first specific enzyme of the isoprenoid pathway, which leads to several classes of primary and secondary metabolites such as sterols, quinones etc.; Pathway: isoprenoid biosynthesis.; Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to hydroxymethylglutaryl-coenzyme A reductase hmg1p -Schizosaccharomyces pombe [truncated ORF]; See PMID 8896278
An04g00620	Remark: C-terminally truncated ORF due to end of contig.; Title: strong similarity to hydroxymethylglutaryl-coenzyme A reductase from patent EP1149919-A2 - Penicillium citrinum [truncated ORF]
An04g00630	Title: strong similarity to hypothetical protein CAC28557.1 - Neurospora crassa
An04g00640	Title: similarity to hypothetical ATP/GTP-binding protein SCC61A.02 - Streptomyces coelicolor
An04g00660	Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins is restricted to a stretch of about 200 amino acids.; Title: strong similarity to hypothetical protein EAA60502.1 - Aspergillus nidulans
An04g00670	Title: strong similarity to hypothetical coiled-coil protein similar to human congenital heart disease protein CAC05252.1 - Schizosaccharomyces pombe
An04g00680	Function: gar2 is required for 18S rRNA and 40S ribosomal subunit accumulation.; Title: similarity to nucleolar protein gar2p -Schizosaccharomyces pombe
An04g00710	Title: weak similarity to hypothetical protein CAC28773.2 - Neurospora crassa
An04g00720	Title: strong similarity to hypothetical protein encoded by An09g02950 - Aspergillus niger
An04g00730	Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa
An04g00740	Title: strong similarity to sterol carrier protein-X/sterol carrier protein-2 SCP2 - Homo sapiens; See PMID 7654720; See PMID 10856712
An04g00750	Title: similarity to hypothetical mitochondrial carrier protein SPBC29A3.11c - Schizosaccharomyces pombe
An04g00760	Title: strong similarity to hypothetical protein palA - Aspergillus nidulans
An04g00770	Title: weak similarity to hypothetical protein WimA - Dictyostelium discoideum
An04g00780	Title: strong similarity to hypothetical protein CAD11370.1 - Neurospora crassa
An04g00790	Catalytic activity: 3-Dehydroquinate = 3-Dehydroshikimate + H2O.; Catalytic activity: Shikimate + NADP+ = 5-Dehydroshikimate + NADPH.; Function: aroM from A. nidulans catalyses 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.; Function: because N-terminal sequences are missing it is likely that only the 3-DEHYDROQUINASE and SHIKIMATE DEHYDROGENASE activities are present.; Remark: the protein is N-terminal significant shorter than the matching protein of A. nidulans.; Title: strong similarity to multifunctional protein aroM - Aspergillus nidulans; See PMID 1648168; See PMID 1849480; See PMID 8257437; See PMID 8383607
An04g00800	Title: strong similarity to hypothetical protein B13I18.170 - Neurospora crassa
An04g00820	Title: similarity to hypothetical protein B1D1.40 -Neurospora crassa
An04g00830	Title: similarity to hypothetical protein T22P22.10 - Arabidopsis thaliana
An04g00840	Title: similarity to hypothetical trfA like protein - Neurospora crassa
An04g00850	Remark: C-terminal truncated due to contig end.; Title: similarity to hypothetical positive sulphur transcription regulator metR - Aspergillus nidulans [truncated ORF]
An04g00860	Remark: truncated ORF due to contig border.; Title: strong similarity to hypothetical protein CAC18137.1 - Neurospora crassa [truncated ORF]
An04g00870	Function: links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis.; Function: yeast MLH3 and murine PMS2 are involved in DNA mismatch repair.; Similarity: shows no similarity in the central part to MLH3 from S. cerevisiae but show similarity almost over the complete length to murine protein PMS2.; Title: similarity to insertion and deletion mismatch repair protein Mlh3 - Saccharomyces cerevisiae; nucleus; See PMID 9770499
An04g00880	Function: biochemical analysis has shown that Csc25 of C. albicans activates the Ras/adenylyl cyclase pathway in S. cerevisiae at a rate two to three times faster than Cdc25 of S. cerevisiae, under the same conditions.; Similarity: restricted to carboxyterminus as usual for the proteins of the CDC25 family; Similarity: the size of proteins of this family ranges from 309 residues (LTE1) to 1596 residues (sos).; Title: similarity to cell division cycle protein CDC25 - Candida albicans; See PMID 8477693
An04g00900	Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: shows only partial similarity to het-e1.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123
An04g00910	Title: strong similarity to hypothetical protein EAA60294.1 - Aspergillus nidulans
An04g00930	Function: ilp is an apoptosis inhibitor.; Similarity: show only partial similarity to ilp.; Title: weak similarity to apoptosis inhibitor IAP homolog ilp - Homo sapiens
An04g00940	Remark: truncated ORF due to contig border.
An04g00950	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity is the predicted A. niger protein and the N-terminal region of M. grisea Pth11 which is 300 aa longer.; Title: weak similarity to membrane protein Pth11 -Magnaporthe grisea; See PMID 10521529
An04g00960	Function: expression of B. abortus gluP functionally complements E. coli strains lacking either glucose or galactose transport systems.; Similarity: B. abortus gluP is a member of the major facilitator superfamily.; Title: strong similarity to glucose/galactose transporter gluP - Brucella abortus; See PMID 9168605
An04g00970	Title: similarity to hypothetical transmembrane protein orf375 - Bradyrhizobium japonicum
An04g00980	Function: B. laterosporus glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA),an intermediate of antibiotica synthesis.; Localization: in B. subtilis extracellular excretion of glutaryl 7-ACA acylase was observed; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 1744041
An04g00990	Catalytic activity: glutamate dehydrogenases convert L-glutamate + H(2)O + NADP(+) to 2-oxoglutarate + NH(3) + NADPH.; Function: A. niger gdhA is a NADP-dependent glutamate dehydrogenases.; Gene-ID: gdhA; Induction: in A. niger very high expression levels of the gdhA gene were observed in media with ammonium or asparagine as the nitrogen source.; Repression: in A. niger glutamic acid repressed transcription of the gdhA gene.; See PMID 9683675
An04g01000	Remark: the blastn similarity to gdh of A. awamori is restricted to a noncoding 5'-flanking region of the gene.
An04g01020	Title: weak similarity to hypothetical helicase-like transcription factor M03C11.8 - Caenorhabditis elegans
An04g01060	Title: weak similarity to olfactory receptor OR5D4 -Homo sapiens; See PMID 9787077
An04g01070	Remark: EcoRI adaptors were later ligated to polished ends.; Remark: EcoRI-XhoI-digested cDNA was ligated with EcoRI-XhoI-digested pYES2 (Invitrogen Corp).; Remark: Synthesis was primed with oligo(dT) primer/XhoI-linker.; Remark: This vector permits expression of our library in yeast.; Remark: cDNA was synthesized with ZAP kit (Stratagene) using poly(A)+ RNA isolated from Aspergillus niger grown in both complete and minimal media.; Title: strong similarity to EST an_2651 -Aspergillus niger
An04g01080	Catalytic activity: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O = ribonucleoside diphosphate + reduced thioredoxin.; Remark: Patentmatch against protein in Geneseqprot DB, AC W41764.; Title: strong similarity to ribonucleotide reductase from patent JP10014582-A - Homo sapiens
An04g01090	Remark: similarities correspond to multiple S-repeats.; Title: weak similarity to proteophosphoglycan ppg1 -Leishmania major; See PMID 10531342
An04g01100	Title: strong similarity to hypothetical protein SPAC227.14 - Schizosaccharomyces pombe
An04g01110	Title: similarity to hypothetical protein 12F11.170 - Neurospora crassa
An04g01120	Catalytic activity: ATP + Tetrahydrofolyl-[Glu](n) + L-Glutamate = ADP + Orthophosphate + Tetrahydrofolyl-[Glu](n+1).; Remark: Mutant yeast cells bearing a fol3 mutation require folinic acid for growth and have no dihydrofolate synthetase activity.; Title: similarity to folylpolyglutamate synthase Fol3 - Saccharomyces cerevisiae; See PMID 10799479
An04g01130	Function: the protein kinase CDC7 of S. pombe is essential for septum formation and cell division.; Localization: Cdc7p shows no discrete localization during interphase, but early in mitosis it associates with both spindle pole bodies and, as the spindle extends, is seen on only one pole of the spindle during anaphase B. Spg1p activity is required for localization of Cdc7p in vivo but not for its kinase activity in vitro.; Remark: Cdc7p kinase and the Spg1p GTPase, with which it interacts, play a central role in signaling the initiation of septum formation.; Remark: overexpression of p120cdc7 causes cell cycle arrest; cells complete mitosis and then undergo multiple rounds of septum formation without cell cleavage.; Title: strong similarity to protein kinase cdc7p -Schizosaccharomyces pombe; See PMID 8039497; See PMID 9420333
An04g01140	Catalytic activity: 6-carboxyhexanoyl-CoA + L-alanine <=> 8-amino-7-oxononanoate + CoA + CO(2).; Cofactor: Pyridoxal-phosphate.; Pathway: biotin biosynthesis.; Title: strong similarity to 8-amino-7-oxononanoate synthase/KAPA synthase BioF - Kurthia sp.; See PMID 11255013
An04g01150	Pathway: myxalamid biosynthesis.; Remark: Myxalamids are polyketide structures with incorporated amino acids produced by myxobacteria. This class of secondary metabolites (epothilons, myxothiazols and myxalamids) often are effective inhibitors of the electron transport via the respiratory chain.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319
An04g01160	Title: strong similarity to hypothetical ABC transporter SPBC15C4.02 - Schizosaccharomyces pombe
An04g01170	Remark: alternate names for S. cerevisiae Isu2: Nua2, YOR226c.; Remark: deletion of either ISU1 or ISU2 results in increased accumulation of iron within the mitochondria,loss of activity of the [4Fe-4S] aconitase enzyme, and suppression of oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase.; Similarity: the ORF encoded protein and Isu2 from S. cerevisiae belong to the NifU-like protein family, NifU of nitrogen-fixing bacteria is involved in the synthesis of the Fe-S cluster of nitrogenase.; Title: strong similarity to protein probably involved in the synthesis of Fe-S clusters Isu2 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10588895; See PMID 10468587
An04g01190	Remark: the human cDNA encoding the folate transporter/carrier complements the glycine auxotrophy of glyB cells (Chinese hamster ovary K1 subline that is deficient in the transport of folates into mitochondria) and reinstated folate accumulation in the mitochondria of transfected cells.; Title: similarity to folate transporter/carrier AAG37834.1 - Homo sapiens; localisation:mitochondrion; See PMID 10978331
An04g01200	Catalytic activity: (Cytochrome bc1 complex) QH(2) + 2 ferricytochrome c <=> Q + 2 ferrocytochrome c.; Function: S. cerevisiae Qcr7 is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.; Remark: alternate names for S. cerevisiae Qcr7: Cor4, Cro1, Ucr7, YDR529C.; Title: strong similarity to 14 kD subunit of ubiquinol--cytochrome c reductase Qcr7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10873857; See PMID 6319130; See PMID 9211895
An04g01210	Function: the S. pombe DNA-3-methyladenine glycosidase I mag1 is involved in the base excision repair pathway. It cleaves the glycosylic bond linking potentially deleterious alkylated bases to the sugar phosphate backbone.; Title: similarity to DNA-3-methyladenine glycosidase I mag1p - Schizosaccharomyces pombe; nucleus; See PMID 10735851; See PMID 8921872
An04g01230	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical ECM33 homolog SPCC1223.12c - Schizosaccharomyces pombe
An04g01250	Remark: blastp matches due to repetitive stretches.; Similarity: the similarity between the ORF and the A. niger protein An08g11670 is restricted to a stretch of less than 200 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11670 - Aspergillus niger
An04g01260	Complex: the complex consists of Mnn9p, Anp1p,Mnn11p, Hoc1p, and Mnn10p.; Function: Anp1p of S. cerevisiae is part of a complex in the cis-Golgi comprising 1,6-mannosyltransferase activity .; Function: this S. cerevisiae complex acts in succession to form and extend the mannan backbone of glycosylated proteins traversing the yeast Golgi.; Title: strong similarity to golgi alpha-1,6 mannosyltransferase subunit Anp1 - Saccharomyces cerevisiae; See PMID 11095735
An04g01270	Similarity: the ORF shows similarity to another A. niger protein. The similarity, however, is restricted to a stretch of about 50 amino acids.; Title: weak similarity to hypothetical protein encoded by An11g03830 - Aspergillus niger
An04g01280	Catalytic activity: hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 4-hydroxyphenylpyruvate + O(2) <=> homogentisate + CO(2); Pathway: hydroxyphenylpyruvate dioxygenase is involved in tyrosine catabolism.; Title: strong similarity to 4-hydroxyphenylpyruvate dioxygenase HPPD - Mycosphaerella graminicola [truncated ORF]; See PMID 9570125
An04g01290	Function: the S. cerevisiae Rad52 protein is involved in double-strand break repair and recombination.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: N. crassa MUS11 = ncRad52.; Title: strong similarity to Rad52 homologue MUS11 -Neurospora crassa [truncated ORF]; See PMID 11129042
An04g01300	Function: the chicken h-caldesmon is a actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). It stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. in muscle tissues, inhibits the actomyosin ATPase by binding to f-actin. this inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. It interacts with actin, myosin, two molecules of tropomyosin and with calmodulin and also plays an essential role during cellular mitosis and receptor capping.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins CG8209 (Drosophila), F23C8. 4 (C. elegans) and SPAC17C9. 11c (S. pombe).; Similarity: the similarity of the ORF encoded protein to h-caldesmon is mainly based on repetitive structures.; Title: similarity to calmodulin- and actin-binding protein h-caldesmon - Gallus gallus; See PMID 2803315
An04g01310	Remark: the SCS2 gene from S. cerevisiae has been cloned as a suppressor of inositol auxotrophy of CSE1 and hac1/ire15 mutants. The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C.; Title: similarity to protein involved in regulation of the inositol biosythesis Scs2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8537323; See PMID 9537365
An04g01320	EC:1.14.99.-; Title: strong similarity to fatty acid desaturase from patent WO9846764-A1 - Homo sapiens
An04g01330	Catalytic activity: L-methionylpeptide + H(2)O <=> L-methionine + peptide.; Cofactor: Cobalt.; Function: the human methionyl aminopeptidase P67EIF2 removes the amino-terminal methionine from nascent proteins.; Remark: alternate name for human methionyl aminopeptidase P67EIF2: p67 or translation initiation factor eIF-2-associated protein.; Title: strong similarity to methionyl aminopeptidase P67EIF2 - Homo sapiens; cytoplasm; See PMID 8858118
An04g01340	Catalytic activity: ATP + L-aspartate + L-glutamine <=> AMP + diphosphate + L-asparagine + L-glutamate.; Remark: alternate name for S. cerevisiae Asn1: YPR145W.; Title: strong similarity to asparagine synthase Asn1 - Saccharomyces cerevisiae; See PMID 8951815; See PMID 348677
An04g01350	Catalytic activity: ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Function: S. pombe Hus5 catalyzes the covalent attachment of ubiquitin to other proteins. It is required for efficient recovery from DNA damage or S-phase arrest and normal mitosis.; Title: strong similarity to E2-type ubiquitin--protein ligase hus5p - Schizosaccharomyces pombe; See PMID 7768995
An04g01360	Remark: expression of DRT111 Arabidopsis thaliana cDNA restored conjugal recombination proficiencies in ruvC and ruvC recG E. coli mutants to nearly wild-type level.; Title: similarity to DNA-damage repair protein precursor DRT111 - Arabidopsis thaliana; See PMID 8479917
An04g01370	Similarity: the ORF encoded protein shows stongest similarity to the S. cerevisae Pcs60 (Fat2,YBR222C) protein from which is known to be localized at peroxisomal peripheral membrane and in the peroxisomal matrix, which could be a long chain acyl-CoA synthetase (Pubmed 8841414). But any specific Pcs60 activity remains unknown yet.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii; See PMID 9826185
An04g01380	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from yeast and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An04g01390	Function: when the human ATA1 cDNA is expressed heterologously in mammalian cells, the cloned transporter mediates Na(+)-coupled transport of the system A-specific model substrate alpha-(methylamino)isobutyric acid.; Title: strong similarity to amino acid transporter ATA1 - Homo sapiens; See PMID 10891391
An04g01400	Title: weak similarity to vacuolar protein Vac7 -Saccharomyces cerevisiae; See PMID 9372916
An04g01410	Similarity: the ORF encoded protein shows strong similarity to the uncharacterized Siw14 (YNL032w) protein from S. cerevisiae. The siw14 null mutant fails to show cell cycle arrest upon nutrient starvation.; Title: similarity to protein fragment SEQ ID NO:6371 from patent EP1033405-A2 - Arabidopsis thaliana
An04g01420	Remark: alternate name for E. coli TatD: MttC.; Remark: the Escherichia coli Tat system mediates Sec-independent export of protein precursors bearing twin arginine signal peptides. Genes known to be involved in this process include tatA, tatB, and tatC that form an operon with a fourth gene, tatD. TatD has no obligate involvement in protein export by the Tat system.; Title: strong similarity to protein with DNase activity tatD - Escherichia coli; See PMID 10747959
An04g01430	Title: weak similarity to hypothetical protein encoded by B11A5.120 - Neurospora crassa
An04g01440	Function: the human Pepsin A shows particularly broad specificity, although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.; Remark: the human Pepsin A is the predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen a by limited proteolysis.; Title: strong similarity to precursor of pepsin A3 -Homo sapiens; extracellular/secretion proteins; See PMID 3197840
An04g01450	Catalytic activity: (S)-2-hydroxy-acid + O(2) <=> 2-oxo acid + H(2)O(2); Similarity: shows similarity o several different oxidoreductases.; Title: similarity to glycolate oxidase GOX - Mus musculus; See PMID 9891009
An04g01460	Remark: protein belongs to a family of mitochondrial long chain acyl-CoA thioesterases.; Title: strong similarity to acyl-CoA thioesterase act48.1 - Mus musculus; localisation:mitochondrion; See PMID 10383425
An04g01470	Title: weak similarity to hypothetical protein CAC37491.1 - Schizosaccharomyces pombe
An04g01480	Catalytic activity: protein of S. cerevisiae converts protein tyrosine phosphate + H2O to protein tyrosine + orthophosphate.; Function: protein of S. cerevisiae is involved in the control network regulating meiosis and sporulation.; Title: strong similarity to protein tyrosine phosphatase Yvh1 - Saccharomyces cerevisiae; See PMID 10464190
An04g01500	Function: the ORF contains zinc-finger domain and therefore might be involved in transcriptional regulation.; Similarity: blast hits result from repetitive sequences.; Similarity: the ORF shows similarity to the A. niger protein An01g13790. The similarity between the two proteins, however, is restricted to a stretch of only about 100 amino acids.; Title: weak similarity to polypeptide SEQ ID NO:21489 from patent WO200171042-A2 - Drosophila melanogaster
An04g01520	Complex: protein of S. pombe is associated with nuclear pore complexes and mitotic spindle pole bodies.; Function: its role as an anchor in the nuclear envelope is essential for mitosis.; Title: similarity to nuclear envelope protein cut11p - Schizosaccharomyces pombe; nucleus; See PMID 9763447
An04g01530	Function: it is required for delivery of VPS10 protein from the Golgi complex to the endosome.; Function: it may mediate the docking of Golgi-derived transport vesicles at the vacuole.; Function: it plays a role in sorting and targeting of vacuolar proteinases.; Function: protein of S. cerevisiae is involved in transport from the Golgi complex to the vacuole.; Title: strong similarity to transport vesicle docking protein Pep12 - Saccharomyces cerevisiae; endosome; See PMID 8730101
An04g01535	Catalytic activity: Holocytochrome c = Apocytochrome c + Heme.; Function: Cyt2 from S. cerevisiae is required for covalent attachment of heme to apocytochrome c1, a subunit of the mitochondrial respiratory chain.; Title: strong similarity to holocytochrome-c synthase Cyt2 - Saccharomyces cerevisiae; See PMID 8082171; See PMID 1499554
An04g01540	Catalytic activity: converts ATP + (R)-5-Diphosphomevalonate = ADP + Orthophosphate + Isopentenyl diphosphate + CO2.; Remark: alternative gene names for S. cerevisiae are MVD1 and MPD.; Title: strong similarity to diphosphomevalonate decarboxylase Erg19 - Saccharomyces cerevisiae; See PMID 8626466; See PMID 1779710
An04g01550	Remark: Disruption of the IKI3 gene in yeast is non-lethal and it has the killer-insensitive phenotype.; Title: strong similarity to killer toxin insensitive protein 3 Iki3 - Saccharomyces cerevisiae; See PMID 9145530
An04g01560	Function: the cytochrome-c oxidase complex catalyzes the oxidation of four molecules of reduced cytochrome c in the intracristal (or intermembrane) space of mitochondria using one oxygen molecule and four protons from the mitochondrial matrix producing two molecules of water and lowering the concentration of protons in the mitochondrial matrix.; Pathway: oxidative phosphorylation; respiratory chain.; Remark: the role of chain VIIc is not clear.; Similarity: shows strong similarity to N. crassa cytochrome-c oxidase chain VIIc.; Title: strong similarity to subunit VIIc of cytochrome c oxidase - Bos primigenius taurus; localisation:mitochondrion; See PMID 213363; See PMID 1655579; See PMID 2554257
An04g01570	Function: This enzyme seems to be a member of the DEAD box helicases that are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport,translation, RNA decay and organellar gene expression.; Function: helicase, the human protein has ATPase activitiy.; Title: strong similarity to helicase SKI2W - Homo sapiens; See PMID 7610041
An04g01580	Remark: the cut8 gene product is required for normal progression of anaphase.; Remark: the temperature sensitivity cut8-563 mutation causes chromosome overcondensation and short spindle formation in the absence of sister chromatid separation.; Title: strong similarity to protein kinase cut8p -Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 8065367; See PMID 10582241
An04g01590	Remark: similarities only with serine rich regions.; Title: weak similarity to profilaggrin FLG - Homo sapiens
An04g01600	Title: strong similarity to hypothetical protein B1D1.80 - Neurospora crassa
An04g01610	Catalytic activity: 2-acetolyctate + CO(2) = 2-pyruvate.; Pathway: first step in valine and isoleucine biosynthesis.; Remark: this enzyme also catalyzes formation of 2-aceto-2-hydroxybutanoate.; Title: strong similarity to acetolactate synthase regulatory chain Ilv6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8972574; See PMID 10213630
An04g01620	Remark: protein has glycine, glutamine and proline rich regions.; Title: similarity to transcription factor ZFM1 -Homo sapiens; See PMID 9212169; See PMID 9506990
An04g01630	Function: A. nidulans recQ helicase is likely to play an important role in the maintenance of genomic integrity.; Title: strong similarity to DNA helicase recQ -Aspergillus nidulans; nucleus; See PMID 10377891; See PMID 11092746
An04g01640	Title: strong similarity to hypothetical protein B23I11.240 - Neurospora crassa
An04g01650	Title: strong similarity to hypothetical protein B23I11.250 - Neurospora crassa
An04g01660	Catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate.; Similarity: shows similarity to other fungal adenylate cyclases.; Title: similarity to adenylate cyclase uac1 -Ustilago maydis; See PMID 7995519; See PMID 9756717
An04g01670	Function: overexpression of SOK1 in S. cerevisiae restores growth to a strain (tpk1 tpk2 tpk3) lacking all A kinase activity.; Remark: S. cerevisiae cyclic AMP-dependent protein kinase (A kinase) activity is essential for growth and cell cycle progression.; Remark: classification according to MIPS funcat.; Title: similarity to suppressor of kinase protein Sok1 - Saccharomyces cerevisiae; nucleus; See PMID 8065298
An04g01680	Title: similarity to hypothetical protein B23I11.190 - Neurospora crassa
An04g01690	Remark: similarity only over alanine, threonine and serine rich regions.; Title: similarity to hypothetical precursor of glycoprotein X - equine herpesvirus 1
An04g01700	Title: strong similarity to hypothetical protein SPAC694.03 - Schizosaccharomyces pombe
An04g01710	Title: strong similarity to hypothetical protein B23I11.140 - Neurospora crassa
An04g01720	Function: DnaJ-domain is part of a chaperone system and involved in protein folding and transportation.; Function: contains a DNAJ domain and might therefore be associated with hsp70-like heat-shock systems.; Title: similarity to DnaJ protein SIS1 -Cryptococcus curvatus; See PMID 9559550
An04g01730	Pathway: involved in N-terminal ubiquitin fusion degradation proteolytic pathway (UFD pathway).; Remark: yeast protein appears to influence the formation and topology of the multi-UB chain.; Similarity: N terminus might be too long or there might exist alternative splicing.; Title: strong similarity to ubiquitin fusion degradation protein Ufd2 - Saccharomyces cerevisiae; See PMID 7615550; See PMID 10089879
An04g01740	Function: Udh1 from U. maydis complements the Arabidopsis steroid reductase mutant det2-1.; Remark: udh1 from U. maydis is induced during the parasitic interaction with its host plant maize.; Title: similarity to steroid 5alpha-reductase UDH1 -Ustilago maydis; See PMID 12068114
An04g01750	Catalytic activity: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.; Title: strong similarity to 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Met6 - Saccharomyces cerevisiae; See PMID 3542720
An04g01760	Similarity: blast hits due to repetive sequences.
An04g01770	Function: DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101 in human.; Remark: DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase in human.; Remark: gaps cannot be closed and may result from sequencing errors that do not allow correct gene prediction.; Title: strong similarity to DNMT1 associated protein-1 DMAP1 - Homo sapiens [putative sequencing error]; See PMID 10888872
An04g01780	Function: contains domain of emp24/gp25L/p24 family and might be involved in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains.; Title: strong similarity to hypothetical protein YAR002c-a - Saccharomyces cerevisiae
An04g01790	Remark: the barA protein was demonstrated in vitro to undergo phosphorylation in the presence of ATP in E. coli.; Title: similarity to sensor-regulator protein barA -Escherichia coli; See PMID 10931332
An04g01800	Localization: PUP3 of S. cerevisiae is cytoplasmic and nuclear.; Remark: PUP3 of S. cerevisiae is also known as SCS32 and has a systematic name of YER094C.; Title: strong similarity to proteasome 20S subunit Pup3 - Saccharomyces cerevisiae; See PMID 9207060; See PMID 9278475; See PMID 10500111
An04g01810	Title: similarity to hypothetical protein AAH19177.1 - Mus musculus
An04g01820	Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L36 L39 - Candida albicans; cytoplasm; See PMID 9364745
An04g01830	Function: the S. pombe homolog in S. cerevisiae is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.; Title: similarity to hypothetical DEC1 protein homolog - Schizosaccharomyces pombe
An04g01840	Similarity: the ORF shows also weak similarity to proteins containing PTS domain.; Title: strong similarity to hypothetical protein EAA63252.1 - Aspergillus nidulans
An04g01850	Similarity: shows similarity to mainly the zf-C3H4C zinc finger domains of several proteins.; Title: similarity to hypothetical zf-C3H4C zinc finger protein SPCC548.05c - Schizosaccharomyces pombe
An04g01860	Function: so far, only one human U3 snoRNA-associated protein, fibrillarin, has been characterized.; Function: the eukaryotic nucleolus contains a large number of small RNA molecules (snoRNAs) which, in the form of small nucleolar ribonucleoprotein complexes (snoRNPs),are involved in the processing and modification of pre-rRNA.; Similarity: shows stronger similarity to fungal snoRNP associated proteins that are not yet described.; Title: similarity to U3 snoRNP associated 55 kDa protein U3-55k - Homo sapiens; nucleus; See PMID 9418896
An04g01870	Protein sequence is in conflict with the conceptual translation; Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Remark: putative sequencing error at position 13492 might have destroyed the start codon.; Title: strong similarity to proteasome 20S subunit Pre1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error
An04g01880	Catalytic activity: UBP4 of M. musculus catalyses ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Function: UBP4 of M. musculus is a ubiquitin thiolesterase, that recognizes and hydrolyze the peptide bond at the C-terminal glycine of ubiquitin, and is therefore involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.; Phenotype: overexpression of UBP4 of M. musculus leads to oncogenic transformation of NIH 3T3 cells.; Remark: an alternate name for UBP4 of M. musculus is UNP.; Title: similarity to ubiquitin thiolesterase 4 UBP4 - Mus musculus; See PMID 9602026
An04g01890	Title: similarity to hypothetical protein CAC28698.1 - Neurospora crassa
An04g01900	Function: beta-transducin (G-beta) is one of the three subunits (alpha, beta, and gamma) of the guanine nucleotide-binding proteins (G proteins) which act as intermediaries in the transduction of signals generated by transmembrane receptors.; Function: the alpha subunit binds to and hydrolyzes GTP; the functions of the beta and gamma subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition.; Similarity: shows higher similarity to undescribed WD (G-beta)-repeat proteins of several organisms.; Title: similarity to Dom34p-interacting protein Dip2 - Saccharomyces cerevisiae; See PMID 9384580
An04g01910	Similarity: some blast hits result from repetitive sequences.; Title: weak similarity to protein involved in spliceosome maturation Spp2 - Saccharomyces cerevisiae
An04g01920	Title: similarity to hypothetical protein SPCC1795.08c - Schizosaccharomyces pombe
An04g01930	Remark: introns can not be integrated, putatively because of sequencing errors.; Title: similarity to protein involved in cell growth and replication of M1 dsRNA Mak11 - Saccharomyces cerevisiae
An04g01940	Similarity: Elongation factor Tu family is overall conserved.; Title: strong similarity to translation initiation factor eIF2 gamma chain Gcd11 - Saccharomyces cerevisiae; cytoplasm; See PMID 7774582; See PMID 9079882
An04g01950	Function: involved in first step of N-terminal processing of the a-factor precursor.; Function: performs the proteolytic removal of the last three amino acids after prenylation of the a-factor precursor.; Title: strong similarity to zinc-metalloprotease Ste24 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9015299; See PMID 9700155
An04g01960	Title: weak similarity to hypothetical protein Y1032 - Yersinia pestis plasmid pMT1
An04g01970	Similarity: shows similarity to several undescribed fungal ribosomal protein L34.; Title: weak similarity to ribosomal protein of the large subunit L34 - Bacillus stearothermophilus
An04g01980	Function: hMP1 is a novel member of the metalloendoprotease superfamily with ubiquitous distribution that could play a broad role in general cellular regulation.; Title: similarity to metalloprotease 1 MP1 - Homo sapiens
An04g01990	Function: human protein is centromere binding protein at prophase, metaphase, and early anaphase.; Function: it also binds kinetochore microtubules at metaphasehuman protein is involved in meiosis and mitosis.; Similarity: similarity is restricted to C-terminus.; Title: similarity to protein ZW10 homolog HZW10 -Homo sapiens
An04g02000	Title: strong similarity to hypothetical microtubule-interacting protein Ytm1 - Saccharomyces cerevisiae
An04g02010	Title: similarity to ribosomal protein of the small subunit S13 rpsM - Bacillus subtilis; localisation:mitochondrion
An04g02020	Function: cyclophilins are an evolutionarily conserved family of proteins which serve as the intracellular receptors for the immunosuppressive drug cyclosporin A.; Function: cypB mRNA levels were significantly elevated under severe heat shock conditions, indicating a possible role for the A. nidulans cyclophilin B protein during growth in high stress environments.; Similarity: shows very high similarity to sequence of patent WO0018934.; Title: strong similarity to cyclophilin cypB -Aspergillus nidulans; endoplasmatic reticulum; See PMID 10413615
An04g02030	Function: may play a role in mRNA splicing and/or in initiation of translation.; Localization: cytoplasmic and nuclear.; Title: strong similarity to ATP-dependent RNA helicase Ded1 - Saccharomyces cerevisiae; See PMID 9045610
An04g02040	Title: similarity to hypothetical protein 15E6.120 -Neurospora crassa
An04g02050	Title: similarity to hypoxia-induced protein #21 from patent WO200246465-A2 - Homo sapiens
An04g02060	Catalytic activity: the first enzymatic activity catalyzing the second last step, the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate, is a 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase.; Catalytic activity: the second enzymatic activity is that of an inosine monophosphate cyclohydrolase, cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.; Function: S. cerevisiae Ade17p belongs to a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis.; Remark: putative sequencing error might have lead to destruction of start codon at pos. 65661 might be a G.; Title: strong similarity to 5-aminoimidazole-4-carboxamide ribotide transformylase Ade17 - Saccharomyces cerevisiae [putative sequencing error]; See PMID 9143321
An04g02070	Complex: clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. in the presence of light chains, hub assembly is influenced by both the ph and the concentration of calcium.; Domain: the c-terminal third of the heavy chains forms the hub of the triskelion. this region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.; Function: clathrin is the major protein of the polyhedral coat of coated pits & vesicles. two different adaptor protein complexes link the clathrin lattice either to the plasma membrane or trans golgi network.; Localization: cytoplasmic face of coated pits and vesicles.; Similarity: belongs to the clathrin heavy chain family.; Title: strong similarity to clathrin heavy chain -Bos taurus; cytoplasm
An04g02080	Remark: the genomic sequence of the predicted A. niger protein has been annotated as 5'UTR of the A. niger pyc gene in EMBL, however no reference justifying this annotation is available.; Title: questionable ORF
An04g02090	Catalytic activity: pyruvate carboxylases convert ATP + pyruvate + HCO(3)(-) to ADP + phosphate + oxaloacetate.; Function: A. niger pyc is involved in the biosynthesis and degradation of citric acid.; Gene-ID: pyc; Localization: in five strains of Aspergillus niger,pyruvate carboxylase activity was detected both in the mitochondrial fraction and in the cytosol.; Localization: under conditions of growth and of citric acid production A. niger pyc was found predominantly or exclusively in the cytosol.; Remark: the A. niger ESTs an_2634, EMBLEST|BE759731,AN01B01, EMBLEST|ANI239747 and an_0874, EMBLEST|BE760887 cover the 3'end of the ORF and the 3'UTR until base 8796.; See PMID 2383004; See PMID 1777859
An04g02100	Function: B. subtilis p-Nitrobenzyl carboxy-esterase pnbA hydrolyses several beta-lactam antibiotic p-Nitrobenzyl esters to the corresponding free acid and p-Nitrobenzyl alcohol.; Remark: p-Nitrobenzyl esters serve as protecting groups on intermediates in the manufacture of clinically important oral beta-lactam antibiotics; de-esterification of the intermediates is required for synthesis of the final product.; Remark: the genomic sequence of the predicted A. niger protein has been annotated as 3'UTR of the A. niger pyc gene in EMBL, however neither ESTs nor any reference justifying this annotation are available.; Title: similarity to p-nitrobenzyl esterase pnbA -Bacillus subtilis
An04g02110	Function: N. crassa con-8 is expressed early during conidial differentiation, its function is unknown.; Regulation: N. crassa con-8 is photoregulated.; Remark: N. crassa con-8 is unusual in that it is transcribed as two mRNA species, 1. 0 and 1. 25 kb in length.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with several A. niger ESTs (an_2280, 2959, 3447, 2227, 1543, 0899 and 1115).; Title: similarity to con-8 - Neurospora crassa; See PMID 7604041; See PMID 521382
An04g02120	Function: S. cerevisiae RPL16 binds to 5S rRNA.; Localization: immunoelectron microscopy mapped RPL16 of S. cerevisiae near the top surface of the central protuberance of the large subunit (60S) of the ribosome,where 60S potentially contacts the 40 S subunit.; Remark: A. niger ESTs an_3183 and 2849 are in accordance with the exon/intron structure of the predicted A. niger protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L16 - Saccharomyces cerevisiae; cytoplasm; See PMID 7510288
An04g02130	Complex: U-1 and U-2 snRNPs contain 11 and 12 protein subunits respectively.; Function: human SmB is present in both U-1 and U-2 snRNPs, which are involved in splicing of nuclear pre-mRNAs.; Function: the 5' splice site (5'SS) and the branch site, which represent the two substrates for the first step of splicing, are first recognized by U1 and U2 snRNPs,respectively.; Title: similarity to U1 and U2 snRNPs component SmB - Homo sapiens; nucleus; See PMID 8371979; See PMID 10397335; See PMID 10490618; See PMID 1825643
An04g02140	Title: strong similarity to hypothetical protein YGL080w - Saccharomyces cerevisiae
An04g02150	Function: glutamine transport by rat SN1 involves H+ exchange as well as Na+ cotransport and, under physiological conditions, mediates glutamine efflux as well as uptake.; Function: rat SN1 is an amino acid transporter mediating glutamine transport with a physiological role in nitrogen metabolism and synaptic transmission.; Title: similarity to amino acid system N transporter SN1 - Rattus norvegicus; plasma membrane; See PMID 10619430
An04g02160	Complex: coimmunoprecipitation suggest a direct interaction of human CIP1 with NKCC.; Function: human CIP1 may be part of a novel family of proteins that modifies the activity or kinetics of CCCs through heterodimer formation.; Function: human CIP1 specifically inhibits human NKCC1-mediated (86)Rb(+) flux if expressed in the oocyte.; Remark: an alternative name for human CIP1 is hCCC6,while CIP1 has also been used as name for the human cyclin interacting protein 1.; Similarity: human CIP1 belongs to the cation-Cl(-) cotransporter (CCC) family.; Title: similarity to cation-Cl-cotransporter-interacting protein CIP1 - Homo sapiens; See PMID 10871601
An04g02170	Title: strong similarity to hypothetical 3-hydroxyacyl-CoA-dehydrogenase hcd - Gibberella zeae
An04g02190	Catalytic activity: S. cerevisiae ERG12 catalyzes the reversible phosphorylation of (R)-mevalonic acid utilizing ATP, this enzyme can also utilize GTP, CTP, and UTP.; Function: S. cerevisiae ERG12 is a mevalonate kinase involved in isoprenoid biosynthesis, specifically in ergosterol biosynthesis.; Function: S. cerevisiae ERG12 is not a rate-limiting enzyme; however its sensitivity to FFP could be a key regulatory mechanism in the sterol pathway of yeast.; Function: mutations in S. cerevisiae erg12/rar1 confer temperature-sensitive growth and increase the mitotic stability of plasmids whose replication is dependent on weak ARS elements.; Remark: alternativ names for S. cerevisiae ERG12 are RAR1 and YMR208W.; Title: strong similarity to mevalonate kinase Erg12 - Saccharomyces cerevisiae; cytoplasm; See PMID 2161381; See PMID 3323847; See PMID 1645230
An04g02200	Title: similarity to hypothetical protein encoded by An16g00980 - Aspergillus niger
An04g02210	Complex: C. albicans RAM2 heterodimerises with CDC43, which contains zinc- and substrate-binding residues.; Function: C. albicans RAM2 is the alpha subunit of protein geranylgeranyltransferase I (GGTase I) a heterodimeric zinc metalloenzyme which catalyse geranylgeranylation of a cysteine residue in proteins containing a C-terminal CaaL motif (C, Cys; a, aliphatic amino acid; L, Leu).; Function: C. albicans mutations in cdc43, lack detectable GGTase I activity, are viable but morphologically abnormal and loclisation of two substrates,Rho1p and Cdc42p, is shifted from the membranous fraction to the cytosolic fraction.; Title: strong similarity to protein geranylgeranyltransferase type I alpha subunit RAM2 -Candida albicans; See PMID 10376828; See PMID 10633104
An04g02220	Catalytic activity: L-serine dehydratases convert L-serine + H(2)O to pyruvate + NH(3) + H(2)O.; Function: S. cerevisiae CHA1 is the catabolic L-serine (L-threonine) dehydratase allowing growth on media with L-serine or L-threonine as sole nitrogen source.; Regulation: S. cerevisiae Cha4p is a positive regulator of CHA1 transcription, binding to the CHA1 5'UTR.; Regulation: S. cerevisiae NHP6A and NHP6B proteins are chromatin architectural factors, required for full induction of the CHA1 gene.; Regulation: S. cerevisiae chromatin-remodeling complex, RSC (remodels the structure of chromatin), is essential for maintaining a repressive chromatin structure at the CHA1 promoter.; Regulation: in S. cerevisiae expression of the CHA1 gene is transcriptionally induced by serine and threonine and inhibited by the presence of other good nitrogen sources.; Remark: A. niger ESTs AN05D04 and Nig095 are in accordance with the predicted Exon-Intron structure of this ORF.; Title: strong similarity to L-serine dehydratase Cha1 - Saccharomyces cerevisiae; See PMID 8246977; See PMID 1628804; See PMID 10329629; See PMID 11118215
An04g02230	Catalytic activity: MetRS convert ATP + L-methionine + tRNA(Met) to AMP + diphosphate + L-methionyl-tRNA(Met); Remark: C. albicans mitochondrial MetRS is distinct from the cytoplasmic MetRS.; Title: strong similarity to mitochondrial methionine--tRNA ligase MetRS - Candida albicans; localisation:mitochondrion; See PMID 9714830
An04g02240	Complex: human NXT1 binds to RNA binding mRNA-export factor TAP (also called NXF1), RNA binding and export inhibiting NXF2 and non RNA binding cytoplasmic NXF3.; Function: human NXT1 binds RanGTP and facilitates nuclear export of different classes of RNA and proteins.; Function: human NXT1 is involved in CRM1 (NES-containing-substrate receptor) dependent protein export and CRM1-independent RNA export.; Function: in nuclear transport each class of macromolecule is thought to have a distinct receptor that mediates the transport reaction; assembly and disassembly reactions of receptor-substrate complexes are coordinated by Ran, whose activity is influenced by NXT1.; Localization: NXT1 colocalizes with the nuclear pore complex (NPC) in mammalian cells and shuttles between the nucleus and the cytoplasm.; Remark: an alternativ name for human NXT1 is p15.; Title: similarity to RanGTP-binding protein NXT1 -Homo sapiens; See PMID 10567585; See PMID 10848583; See PMID 11073998
An04g02250	Title: questionable ORF
An04g02260	Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2427 and 1054.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L38 - Rattus norvegicus; cytoplasm
An04g02270	Title: strong similarity to hypothetical protein SPAC577.03c - Schizosaccharomyces pombe
An04g02280	Complex: S. cerevisiae HYS2, CDC2 and POL32 heterotrimerise to form DNA-Pol III.; Function: S. cerevisiae DNA polymerase III plays an important role in DNA repair after irradiation,particularly in the error-prone and recombinational pathways.; Function: S. cerevisiae HYS2 is the 55kDa subunit of DNA dependent DNA-polymerase (DNA polymerase III (delta)) involved in DNA replication, base-excision repair, mismatch repair and post-replication repair.; Remark: alternative names for S. cerevisiae HYS2 are HUS2, POL31, SDP5 and YJR006W.; Title: strong similarity to subunit of DNA polymerase III (delta) Hys2 - Saccharomyces cerevisiae; nucleus; See PMID 7567461; See PMID 9258670; See PMID 9421503; See PMID 9677406
An04g02300	Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Remark: a splice site was detected upstream of the START codon.; Title: similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344
An04g02310	Function: chicken MDP77 promotes the neurite-outgrowth from the cultured chick neurons of the spinal cord in a dose-dependent manner.; Localization: transfected COS-7 cells secrete chicken MDP77 into the culture medium.; Title: similarity to neurite-outgrowth-promoting protein MDP77 - Gallus gallus; extracellular/secretion proteins; See PMID 10708594
An04g02320	Similarity: human MP1 is a metalloendoproteases of the pitrilysin family.; Title: strong similarity to metalloprotease 1 MP1 -Homo sapiens; See PMID 10360838
An04g02340	Title: weak similarity to kinesin light chain -Strongylocentrotus purpuratus
An04g02350	Remark: similarity to human FLEXHT-35 protein sequence SEQ ID NO:35 patent WO200070047-A2.; Title: similarity to FLEXHT-35 protein sequence SEQ ID NO:35 from patent WO200070047-A2 - Homo sapiens
An04g02360	Function: this protein removes the n-acetyl group from bialaphos as one of the final steps of the bialaphos biosynthetic pathway.; Pathway: bialaphos biosynthesis.; Remark: the observation that Bah was similar to a rat and to a bacterial (Acinetobacter calcoaceticus) lipase probably reflects the fact that the ester bonds of triglycerides and the amide bond linking acetate to phosphinothricin are similar and hydrolysis is catalyzed by structurally related enzymes.; Remark: the predicted ORF is approximately 80 amino acids to long.; Similarity: belongs to the 'gdxg' family of lipolytic enzymes.; Similarity: belongs to the acetyl esterase family.; Title: similarity to bialaphos acetylhydrolase Bah -Streptomyces hygroscopicus; See PMID 2066341
An04g02380	Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Function: might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment. Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.; Localization: the rat GTK1 is localized in the mitochondial matrix.; Similarity: belongs to the gst superfamily, kappa family.; Title: similarity to subunit 13 of glutathione S-transferase GTK1 - Rattus norvegicus; See PMID 8920976; See PMID 1883325
An04g02400	Localization: in G2-arrested cells, dsk1 locates in the cytoplasm, whereas in mitotically arrested cells,nuclear stain is intense.; Remark: dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. It auto-phosphorylates as well as phosphorylates myelin basic protein (MBP). Phosphotyrosine as well as phosphoserine/threonine were found in autophosphorylation, but no tyrosine phosphorylation occurs when MBP was used as the substrate.; Title: strong similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317
An04g02410	Function: might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: cobalamin biosynthesis.; Remark: strong similarity to P. denitrificans COB W patent WO9111518-A.; Title: strong similarity to cobalamin and cobamide biosynthesis protein COB W from patent WO9111518-A -Pseudomonas denitrificans; See PMID 1655697
An04g02420	Catalytic activity: L-ornithine = putrescine + CO2.; Pathway: urea cycle and metabolism of amino groups; arginine and proline metabolism; alkaloid biosynthesis II.; Remark: putative sequencing error at position 46804,1 bases too much.; Remark: yeast growth and mycelium-to-yeast transition in P. brasiliensis were accompanied by a high activity of ornithine decarboxylase at the onset of the budding process, the activity of which was inhibited by 1,4-diamino-2-butanone. The activity of ornithine decarboxylase remained at a basal level during vegetative growth of both the mycelial phase and the late stage of yeast phase, and also through the yeast-to-mycelium transition.; Title: strong similarity to ornithine decarboxylase ODC - Paracoccidioides brasiliensis [putative frameshift]; putative frameshift; See PMID 8661922; See PMID 9082919
An04g02450	Title: similarity to hypothetical protein CAE76574.1 - Neurospora crassa
An04g02460	Function: mitofilin, also known as heart muscle protein, is a mitochondrial protein. During mitochondrial in vitro import, mitofilin is proteolytically processed to the mature protein that is also detected in cellular fractions, indicating that the amino-terminal leader sequence is removed.; Similarity: the ORF overlaps with A. niger ESTs (EMBLEST:BE760804) an_0696 and (EMBLEST:BE760883) an_0869.; Similarity: the ORF shows similarity to some motor proteins, like myosin heavy chain.; Title: strong similarity to heart muscle protein mitofilin HMP - Homo sapiens; See PMID 8039717; See PMID 8886976; See PMID 9168817
An04g02470	Remark: the ypt/rab proteins are a family of small GTP-binding proteins thought to be required for different stages of membrane traffic. Ypt5 protein expressed in mammalian cells colocalized with the transferrin receptor to early endosomes.; Title: strong similarity to GTP-binding protein ypt5p - Schizosaccharomyces pombe; See PMID 8226998; See PMID 8374169
An04g02480	Remark: Sac1p shares primary sequence homology with a subfamily of cytosolic/peripheral membrane phosphoinositide phosphatases, the synaptojanins which have approximately the same lenght.; Remark: the SAC1 gene product (Sac1p) is an integral membrane protein of the endoplasmic reticulum and the Golgi complex.; Title: strong similarity to lipid phosphoinositide phosphatase Sac1 - Saccharomyces cerevisiae; See PMID 2687291
An04g02490	Catalytic activity: ATP + tetrahydrofolyl-[Glu](n) + L-glutamate = ADP + orthophosphate + tetrahydrofolyl-[Glu](n+1).; Function: S. cerevisiae strains without functional met7 are methionine, adenine and thymidine auxotroph and maintenance of mitochondrial DNA is disturbed.; Localization: similar to other eukaryotes, yeasts have parallel pathways of one-carbon metabolism in the cytoplasm and mitochondria and have folylpolyglutamate synthetase activity in both compartments.; Pathway: folate biosynthesis.; Remark: alternate names are MET23, YOR241w .; Remark: one-carbon metabolism is essential to provide activated one-carbon units in the biosynthesis of methionine, purines, and thymidylate. The major forms of folates in vivo are polyglutamylated derivatives. In organisms that synthesize folate coenzymes de novo, the addition of the glutamyl side chains is achieved by the action of two enzymes, dihydrofolate synthetase and folylpolyglutamate synthetase.; Similarity: belongs to the folylpolyglutamate synthase family.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10775416; See PMID 10799479
An04g02500	Catalytic activity: tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.; Remark: myristoyl-CoA:protein N-myristoyltransferase (Nmt) transfers myristate from CoA to the N-terminal Gly residue of cellular proteins in an ordered reaction mechanism that first involves binding of myristoyl-CoA to the apoenzyme.; Similarity: belongs to the acyltransferases.; Title: strong similarity to glycylpeptide N-tetradecanoyltransferase Nmt - Ajellomyces capsulatus; See PMID 8300631
An04g02510	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical membrane protein YOR118w - Saccharomyces cerevisiae
An04g02520	Remark: similarity to Micrococcus luteus HexPS gene prenyl diphosphate synthetase hex2 patent EP812914-A2.; Remark: substances synthesised by PDS, i. e. polyprenyl diphosphates, are precursors of physiologically active substances, e. g. vitamin K and ubiquinones.; Title: similarity to prenyl diphosphate synthetase hex2 from patent EP812914-A2 - Micrococcus luteus
An04g02530	Title: similarity to hypothetical extensin-like protein Pex2 - Zea mays
An04g02540	Remark: similarity to human bladder tumour EST encoded protein 16 patent DE19818619-A1.; Remark: the predicted ORF is about 150 amino acids longer than the found homologues.; Title: similarity to bladder tumour EST encoded protein 16 from patent DE19818619-A1 - Homo sapiens
An04g02550	Remark: disruption of the chromosomal copy of the mef1 gene in a wild-type haploid yeast induced a phenotype analogous to that of the original mutant, but does not affect cell viability. These result indicate that the gene product function exclusively in mitochondrial protein synthesis.; Similarity: to translation elongation factor G.; Title: strong similarity to mitochondrial translation elongation factor EF-G Mef1 - Saccharomyces cerevisiae; See PMID 1935960
An04g02570	Remark: similarity to human secreted protein, SEQ ID NO: 8043 patent EP1033401-A2.; Similarity: the ORF shows strong similarity to EST SEQ ID NO:4027 - Aspergillus niger.; Title: similarity to hypothetical membrane protein YML030w - Saccharomyces cerevisiae
An04g02580	Catalytic activity: L-threonine + H2O = 2-oxobutanoate + NH3 + H2O.; Pathway: glycine, serine and threonine metabolism.; Remark: the AILV1 gene is a suitable auxotrophic selection marker in transformation experiments using an Arxula adeninivorans ilv1 mutant and a plasmid containing this gene, which is fused into the 25S rDNA of Arxula adeninivorans.; Remark: the enzyme from a number of sources also acts on L-serine.; Similarity: belongs to the threonine dehydratases.; Title: strong similarity to threonine deaminase ILV - Arxula adeninivorans; See PMID 9730281
An04g02600	Catalytic activity: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Pathway: inositol phosphate metabolism.; Remark: Aspergillus niger NRRL 3135 produces two phytases one with pH optima at 2. 5 and 5. 5 (phyA) and one with an optimum at pH 2. 0 (phyB).; Remark: phytases (myo-inositol hexakisphosphate phosphohydrolase, EC 3. 1. 3. 8) catalyse the release of phosphate from phytate (mycoinositol hexakiphosphate). Several cereal grains, legumes and oilseeds, etc., store phosphorus as phytate. Environmental pollution due to the high-phosphate manure, resulting in the accumulation of P at various locations has raised serious concerns.; Similarity: belongs to the histidine acid phosphatase family.; Title: strong similarity to 3-phytase B phyB -Aspergillus niger; See PMID 7916610; See PMID 8865587
An04g02610	Catalytic activity: succinate semialdehyde + NAD+ or NADP+ + H2O = succinate + NADH or NADPH.; Function: in higher eucaryotes Succinate-semialdehyde dehydrogenases are required for the catabolism of GABA intermediates. Mutations of Succinate-semialdehyde dehydrogenases in higher eucaryotes give rise to central nervous system dysfunction.; Pathway: 4-aminobutyrate (GABA) degradation pathway.; Remark: in E. coli gabD is required for the utilisation of 4-hydroxyphenylacetate as nitrogene source.; Similarity: belongs to the aldehyde dehydrogenase family.; Title: strong similarity to succinate-semialdehyde dehydrogenase NAD(P)+ gabD - Escherichia coli; See PMID 2254272; See PMID 8297211
An04g02620	Title: similarity to hypothetical protein CAE76577.1 - Neurospora crassa
An04g02630	Remark: N-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical membrane protein YGR103w - Saccharomyces cerevisiae [truncated ORF]
An04g02640	Remark: pes mRNA is expressed widely and dynamically during the first 3 days of embryogenesis.; Title: strong similarity to protein pescadillo -Homo sapiens; See PMID 8985183
An04g02650	Remark: CECRPs are activators of cell proliferation or inhibitors of cellular processes that modulate proliferation.; Remark: the patent does not provide further information about the function of the protein.; Remark: the sequence of human cell cycle regulation protein-4 (CECRP-4) is also covered by patents WO200058473-A2 (AC# AAB43252) and WO200017222-A1 (AC# AAB08956). the latter claims the protein to be secreted.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of human cell cycle regulation protein-4 (CECRP-4) of patent WO9964593-A2 (AC# AAY44363), strong similarity to the hypothetical cell division control protein CDC91 from S. cerevisiae and other hypothetical proteins from diverse eucaryotic species.; Title: strong similarity to cell cycle regulation protein-4 (CECRP-4) from patent WO9964593-A2 - Homo sapiens
An04g02660	Title: similarity to hypothetical protein SPCC825.04c - Schizosaccharomyces pombe
An04g02670	Function: catalyzes the reduction of a wide range of aldehydes (but not e. g. acetaldehyde) and ketones.; Remark: may be involved in detoxification of reactive carbonyl-containing compounds.; Title: strong similarity to NADPH-dependent aldehyde reductase - Sporobolomyces salmonicolor; See PMID 1633196
An04g02690	Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532-A - Unclassified organism
An04g02700	Function: Raffinose synthase is involved in the biosynthesis of raffinose and higher homologues in the raffinose saccharide family from sucrose.; Similarity: shows also similarities to imbibition proteins of a variety of plants whsoe sequences are not yet published.; Title: similarity to wheat raffinose synthase from patent WO200024915-A2 - Triticum aestivum
An04g02710	Function: the murine beta-carotene 15,15'-dioxygenase beta-CD cleaves beta-carotene to all-trans-retinal (vitamin A).; Title: strong similarity to beta-carotene 15,15-dioxygenase beta-CD - Mus musculus; See PMID 11092891
An04g02720	Similarity: the human BNPI transporter is identical to the protein described in patent WO9838203-A1.; Title: similarity to brain-specific Na-dependent inorganic phosphate cotransporter BNPI - Homo sapiens; plasma membrane; See PMID 9786972; See PMID 10820226; See PMID 8202535
An04g02730	Function: the ribonuclease H (RnhA) from Escherichia coli is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically. In E. coli RNAse H participates in DNA replication. It helps to specify the origin of genomic replication by suppressing initiation at origins other than the locus oriC. Along with the 5'-3' exonuclease of DNAPol1, it removes RNA primers from the Okazaki-fragments of lagging strand synthesis and it defines the origin of replication for cole1-type plasmids by specific cleavage of an RNA preprimer.; Similarity: the ORF DNA sequence shows also strong similarity to the sequence of EST an_2834 from Aspergillus niger.; Title: similarity to ribonuclease H rnhA -Escherichia coli; See PMID 2171503; See PMID 6302075; See PMID 6316347
An04g02740	Function: the human HUPF1 protein plays an important role in the nonsense-mediated mRNA decay (NMD). It displays a nucleic-acid-dependent ATPase activity and a 5'--> 3' helicase activity.; Title: similarity to nonsense mRNA-reducing protein Hupf1 - Homo sapiens; cytoplasm; See PMID 10999600; See PMID 9064659
An04g02750	Title: weak similarity to glycinin A5A4B3 subunit from patent JP61132189-A - Glycine max
An04g02760	Function: the E. coli RspA protein is probably involved in the degradation of homoserine lactone, which may be a general signal of starvation.; Title: strong similarity to starvation-sensing protein rspA - Escherichia coli; See PMID 7545940
An04g02770	Catalytic activity: 2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + NADH.; Pathway: the KduD protein from Erwinia chrysanthemi involved in the pentose and glucuronate interconversions.; Title: strong similarity to 2-deoxy-D-gluconate 3-dehydrogenase KduD - Erwinia chrysanthemi; See PMID 1766386
An04g02780	Function: the PVA enzyme described in patent US5516679-A is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Similarity: the ORF encoded protein shows strong similarity to the tannase fromAspergillus oryzae (Pubmed 8917102).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum
An04g02790	Function: Lac12 from K. lactis mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; plasma membrane; See PMID 3053697
An04g02800	Catalytic activity: L-proline + NAD(P)(+) <=> 1-pyrroline-5-carboxylate + NAD(P)H.; Pathway: ProC from Pseudomonas aeruginosa catalyzes the terminal (third) step in proline biosynthesis.; Title: strong similarity to pyrroline-5-carboxylate reductase ProC - Pseudomonas aeruginosa; See PMID 2107123
An04g02810	Title: weak similarity to choline kinase from patent WO9812346-A1 - Streptococcus pneumoniae
An04g02830	Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: a putative frameshift results in a premature STOP codon.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: the ORF encoded protein shows also strong similarity to the allantoate transporter Dal5/YJR152W from S. cerevisiae, but the accessible literature does not describe any functional characterization of Dal5 (Pubmed 3275614).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 10869563
An04g02840	Catalytic activity: (S)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c.; Cofactor: FMN; Protoheme IX.; Localization: the L-lactate dehydrogenase CYB2 from Pichia anomala is localized in the mitochondrial intermembrane space.; Remark: Pichia anomala=Hansenula anomala.; Remark: a putative frameshift results in a premature STOP codon.; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala [putative frameshift]; localisation:mitochondrion; putative frameshift; See PMID 3319613; See PMID 2688640; See PMID 2813072
An04g02850	Function: the X-Pro dipeptidyl-peptidase IV -Xanthomonas maltophilia cleaves Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-P-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.; Remark: Xanthomonas maltophilia=Stenotrophomonas maltophilia.; Remark: the X-Pro dipeptidyl-peptidase IV from Xanthomonas maltophilia can be inhibited by diisopropyl phosphofluoridate.; Title: similarity to X-Pro dipeptidyl-peptidase IV -Xanthomonas maltophilia; See PMID 9010758
An04g02870	Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to histone H1 - Nicotiana tabacum
An04g02880	Catalytic activity: L-glutaminyl-peptide <=> 5-oxoprolyl-peptide + NH(3).; Function: the human glutaminyl-peptide cyclotransferase QPCT is responsible for the biosynthesis of pyroglutamyl peptides. It has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.; Title: strong similarity to glutaminyl-peptide cyclotransferase QPCT - Homo sapiens; See PMID 7999256
An04g02890	Title: weak similarity to LP-76-related adaptor molecule Clnk - Mus musculus
An04g02900	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to nucleolar phosphoprotein xNopp180 - Xenopus laevis
An04g02910	Similarity: the ORF encoded protein shows significant similarity to some conserved hypothetical proteins e. g PA2764 (Pseudomonas aeruginosa).; Title: weak similarity to nitrogenase 2 vanadium-iron protein beta chain - Azotobacter vinelandii
An04g02920	Title: weak similarity to hypothetical protein CG3556 - Drosophila melanogaster
An04g02930	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An04g02940	Title: strong similarity to hypothetical protein B24P7.350 - Neurospora crassa
An04g02950	Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotricodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An04g02970	Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.; Function: FMO is involved in the metabolism of many drugs, pesticides, and other foreign compounds, including xenobiotics, by catalyzing the NADPH-dependent oxidation of various substrates.; Title: similarity to dimethylaniline monooxygenase FMO - Sus scrofa; See PMID 2322534; See PMID 2383273
An04g02980	Catalytic activity: AAO uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Function: Aryl-alcohol oxidase (AAO) is involved in lignin degradation by Pleurotus pulmonarius.; Remark: AAO is an extracellular glycoprotein with 14% N-carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774
An04g02990	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An04g03000	Function: ankyrins are linker proteins, which connect various membrane proteins with the submembranous actin-spectrin skeleton.; Remark: truncated ORF due to the contig end.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster [truncated ORF]; See PMID 7937942; See PMID 10844021
An04g03010	Remark: MP1 has high affinity for concanavalin A, a characteristic indicative of a mannoprotein.; Title: similarity to cell wall antigen MP1 -Penicillium marneffei; cell wall; See PMID 9488383; See PMID 9738061
An04g03030	Function: radixins are ross-linkers between plasma membranes and actin-based cytoskeletons.; Remark: protein is shorter at the N-terminus than the database proteins.; Remark: the ERM family consists of three closely related proteins, ezrin, radixin, and moesin.; Title: similarity to radixin - Sus scrofa; cytoskeleton; See PMID 8268231; See PMID 9013673; See PMID 10574907
An04g03040	Title: weak similarity to hypothetical late embryonic abundant protein EMB23 - Picea glauca
An04g03050	Alternative name: MSH6, PMS3, YDR097C.; Complex: forms complex with Msh2p to repair both single-base and insertion-deletion mispairs in yeast.; Function: required for mismatch repair in mitosis and meiosis in yeast.; Title: strong similarity to DNA mismatch repair protein Msh6 - Saccharomyces cerevisiae; nucleus; See PMID 8600025; See PMID 8723353; See PMID 8816473
An04g03060	Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + pyrophosphate + L-tyrosyl-tRNA(Tyr).; Function: the protein CYT-18 of Neurospora crassa has two functions: aminoacyl-tRNA synthetase and is involved in the splicing of group I introns.; Remark: it acts in intron splicing by stabilizing the catalytically active structure of the intron.; Title: strong similarity to mitochondrial tyrosine--tRNA ligase CYT-18 - Neurospora crassa; localisation:mitochondrion; See PMID 2143700; See PMID 3607872
An04g03070	Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe
An04g03080	Remark: the Na(+)-hypersensitive phenotype of the hol1-mutation is correlated with increased uptake and accumulation of this ion in yeast.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402; See PMID 2405251
An04g03090	Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor
An04g03100	Catalytic activity: cocaine is hydrolyzed to ecgonine methyl ester and benzoate.; Function: the cocaine esterase was found to initiate degradation of cocaine in Rhodococcus sp.; Remark: Rhodococcus sp. utilizes cocaine as a sole source of carbon and nitrogen for growth.; Title: strong similarity to cocaine esterase cocE -Rhodococcus sp.; See PMID 10698749
An04g03110	Catalytic activity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).; Remark: MSD1 is a nuclear gene.; Title: strong similarity to mitochondrial aspartate--tRNA ligase Msd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10710420; See PMID 2668951
An04g03120	Function: Cox10 is required for the synthesis of cytochrome oxidase in yeast, espacially needed for heme A synthesis.; Remark: nuclear gene.; Similarity: shows also similarity to heme A farnesyltransferases.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8078902; See PMID 8118433
An04g03130	Remark: a lec35 mutation of Chinese hamster affects the participation of mannose-P-dolichol (MPD) in dolichol-P-P-oligosaccharide biosynthesis in vivo.; Remark: lec35 mutations are mannosylation-defective in Chinese hamster ovarian cells.; Remark: stop codon at position 26450-26448.; Title: strong similarity to mannosylation protein Lec35 - Cricetulus griseus [putative sequencing error]; putative sequencing error; See PMID 8454644; See PMID 8454645; See PMID 11179430
An04g03140	Alternative name: MED8, YBR193c.; Complex: specifically binds to upstream activating sequences (UASs) of SUC2 promoter, to downstream repressing sequences (DRSs) of the HXK2 gene and to the carboxy-terminal domain of the RNA polymerase II in yeast.; Function: Med8 act as coupling factor by linking activating and repressing transcription complexes to the RNA polymerase II holoenzyme transcriptional machinery in yeast.; Title: similarity to transcription factor Med8 -Saccharomyces cerevisiae; nucleus; See PMID 9918841; See PMID 10526178
An04g03150	Title: weak similarity to hypothetical protein SPCP31B10.04 - Schizosaccharomyces pombe
An04g03160	Remark: only weak partial similarity to aminomethyltransferase from the yeast S. cerevisiae.; Similarity: the ORF shows strong similarity to the A. niger protein An07g04910. The similarity between the two proteins, however, is restricted to a stretch of about 130 amino acids.; Title: similarity to hypothetical protein encoded by An07g04910 - Aspergillus niger
An04g03170	Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: yeast Candida wickerhamii exports a cell-associated beta-glucosidase that is active against cellobiose and all soluble cellodextrins.; Title: strong similarity to beta-glucosidase bglB -Candida wickerhamii; See PMID 8929394; See PMID 7574590
An04g03180	Title: strong similarity to hypothetical protein EAA64005.1 - Aspergillus nidulans
An04g03190	Title: weak similarity to hypothetical protein F28C11.17 - Arabidopsis thaliana
An04g03200	Catalytic activity: D-mannose 6-phosphate = D-fructose 6-phosphate.; Remark: protein is involved in the synthesis of GDP-mannose and dolichol-phosphate mannose in mannosyl transfer reactions in the glycosylation and mannosylation pathways.; Title: strong similarity to mannose-6-phosphate isomerase manA - Candida albicans; See PMID 8180205; See PMID 7702743; See PMID 7785330
An04g03210	Title: weak similarity to protein E2 - Human papillomavirus type 76
An04g03220	Title: similarity to hypothetical protein YKR089c -Saccharomyces cerevisiae
An04g03240	Remark: truncated due to contig end.
An04g03250	Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Remark: truncated ORF due to the contig end.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina [truncated ORF]; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123
An04g03260	Remark: general weak similarity to several different proteins involved in protein-protein interaction.; Similarity: weak similarity to desmoplakin I and centrosome associated protein CEP250 from H. sapiens.; Title: weak similarity to myosin heavy chain - Homo sapiens
An04g03270	Complex: the 26S proteasome of S. cerevisiae contains a 20S catalytic core and a 19S regulatory subunit.; Function: regulatory subunit of the 26S proteasome of S. cerevisiae.; Function: the 26S proteasome degrades ubiquinated proteins.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn2 - Saccharomyces cerevisiae; nucleus
An04g03290	Catalytic activity: acyl-CoA + ETF <=> 2,3-dehydroacyl-CoA + reduced ETF.; Complex: forms with another flavoprotein (ETF = 'Electron-Transferring Flavoprotein') and EC 1. 5. 5. 1 a system reducing ubiquinone and other acceptors.; Localization: mitochondrial matrix in Rattus norvegicus.; Pathway: initial step of the mitochondrial fatty acid beta-oxidation system.; Remark: a number of acyl-CoA dehydrogenases of different substrate specifity are present in all organisms.; Remark: closest manual homolog (BLASTP): PIR:A34252 long-chain-acyl-CoA dehydrogenase precursor - Rattus norvegicus.; Title: strong similarity to long-chain acyl-CoA dehydrogenase - Rattus norvegicus; localisation:mitochondrion; See PMID 2777793; See PMID 8268228; See PMID 10760462
An04g03300	Complex: SPT4 and SPT5 from S. cerevisiae form a complex that does not contain SPT6.; Function: STP5 from S. cerevisiae is a transcription elongation protein.; Title: strong similarity to transcription elongation protein Spt5 - Saccharomyces cerevisiae; nucleus
An04g03310	Remark: high proline and glutamine content is indicative for various polynucleotide-binding domains.; Similarity: N-terminal region with high proline and glutamine content shows similarities to different DNA-directed RNA polymerases, C-terminal region shows similarity to mRNA-capping-enzyme of S. pombe.; Title: similarity to hypothetical mRNA-capping enzyme subunit SPAC644.04 - Schizosaccharomyces pombe; See PMID 9345280
An04g03320	Function: TTG1 is potentially involved in signal transduction to downstream transcription factors in A. thaliana.; Function: protein regulates the trichome differentiation and anthocyanin biosynthesis in Arabidopsis thaliana.; Similarity: strong similarity to hypothetical protein YPL247 form S. cerevisiae.; Similarity: strong similarity to putative beta transducin from S. pombe.; Similarity: ttg1 from A. thaliana contains four WD40 repeats.; Title: similarity to transparent testa glabra1 TTG1 - Arabidopsis thaliana; See PMID 10402433
An04g03330	Title: strong similarity to hypothetical protein SPAC1F12.08 - Schizosaccharomyces pombe
An04g03340	Title: weak similarity to hypothetical syntaxin 8 related protein B13N20.240 - Neurospora crassa
An04g03350	Function: Ral2 from S. pombe probably is a GDP - GTP exchange factor for Ras1; Phenotype: deletion mutant shows no response to the mating pheromone, but their vegetative growth was apparently normal in S. pombe.; Title: similarity to ras1 activating gene ral2p -Schizosaccharomyces pombe
An04g03360	Catalytic activity: Phosphatidylcholine + H(2)O <=> 1-acylglycerophosphocholine + a fatty acid anion.; Function: aiPLA2 degrades internalized phosphatidylcholine in R. norvegicus.; Localization: in lysosomal fraction of R. norvegicus lung epithelium.; Title: strong similarity to acidic Ca(2+)-independent phospholipase A2 aiPLA2 - Rattus norvegicus; See PMID 9612290
An04g03380	Title: strong similarity to hypothetical protein My005 - Homo sapiens
An04g03400	Catalytic activity: Aldehyde + NAD+ + H2O = Carboxylate + NADH.; Localization: different aldh isozymes are located in the mitochondria and cytoplasm.; Title: strong similarity to aldehyde dehydrogenase aldA - Aspergillus niger; See PMID 2606357; See PMID 1644309
An04g03420	Function: regucalcin from R. norvegicus has an inhibitory effect on the activation of Ca2+/calmodulin-dependent enzymes and protein kinaseC and regulates nuclear function in liver cells; it can inhibit Ca(2+)-activated DNA fragmentation, DNA and RNA synthesis,protein kinase and protein phosphatase activities in the nuclei.; Function: regucalcin from R. norvegicus is a calcium-binding protein that does not contain the EF-hand motif, it is a regulatory protein in Ca2+ signaling,maintaining intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane and microsomal membranes of liver and kidney cells.; Title: strong similarity to regucalcin also known as senescence marker protein-30 SMP30 - Rattus norvegicus; See PMID 8348951; See PMID 9792046; See PMID 1420310; See PMID 10809175; See PMID 1581340
An04g03440	Remark: the blastp hits are due to the serine-rich ORF sequence.; Similarity: the ORF shows strong similarity to the A. niger EST an_3444.; Title: similarity to novel polypeptide sequence SEQ ID NO:1786 from patent WO2003029271-A2 - Homo sapiens
An04g03460	Catalytic activity: 3-phytase catalyzes the conversion of myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Function: catalyzes the hydrolysis of phytic acid into myo-inositol and inorganic phosphate.; Gene-ID: phyA; Pathway: inositol phosphate metabolism.; extracellular/secretion proteins; See PMID 8865587; See PMID 9349716; See PMID 10087168; See PMID 10223979; See PMID 10328821
An04g03490	Title: similarity to hypothetical protein AAN10358.2 - Drosophila melanogaster
An04g03495	Complex: Swp1 from S. cerevisiae is a component of the oligosaccharyltransferase complex.; Function: Swp1 from S. cerevisiae interacts physically with Wbp1.; Function: Swp1 from S. cerevisiae was isolated as a suppressor of a mutation in wbp1, an essential component of the N-oligosaccharyl transferase.; Title: similarity to oligosaccharyltransferase delta subunit Swp1 - Saccharomyces cerevisiae; See PMID 8175708; See PMID 8428586
An04g03500	Title: weak similarity to glycoprotein gpv -Varicella-zoster virus
An04g03520	Title: questionable ORF
An04g03530	Function: NAD-dependent D-arabinitol dehydrogenase ARD of C. tropicalis interconverts D-arabinitol plus NAD with D-ribulose plus NADH.; Similarity: shows strong similarity to several short chain dehydrogenase/reductases with different specificities.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655
An04g03570	Function: pyridoxine 4-dehydrogenase PLR of S. pombe catalyzes the reduction of pyridoxal by NADPH to form pyridoxine and NADP+.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489
An04g03580	Title: similarity to hypothetical protein BAA97223.1 - Arabidopsis thaliana
An04g03590	Catalytic activity: lysophospholipase catalyzes the conversion of 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.; Pathway: phospholipid degradation.; Title: strong similarity to lysophospholipase from patent WO0127251 - Aspergillus oryzae
An04g03600	Title: strong similarity to hypothetical protein EAA64794.1 - Aspergillus nidulans
An04g03620	Catalytic activity: 2-dehydro-3-deoxyphosphoheptonate aldolase catalyzes the conversion of 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + orthophosphate = phosphoenolpyruvate + D-erythrose 4-phosphate + H2O.; Pathway: 2-dehydro-3-deoxyphosphoheptonate aldolase catalyzes the first step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway).; Title: similarity to 2-dehydro-3-deoxyphosphoheptonate aldolase - Arabidopsis thaliana
An04g03630	Title: strong similarity to hypothetical transport protein YCR023c - Saccharomyces cerevisiae
An04g03640	Similarity: the ORF shows weak (but specific) similarity to the A. niger protein An17g02290. The similarity between the two proteins, however, is restricted to a stretch of about 140 amino acids.; Title: weak similarity to hypothetical protein SPAC4H3.11c - Schizosaccharomyces pombe
An04g03650	Remark: blast matches are due to repetitive sequence.
An04g03660	Title: weak similarity to hypothetical protein YLR094c - Saccharomyces cerevisiae
An04g03680	Title: similarity to glucanase ZmGnsN4 from patent WO200073470-A2 - Zea mays
An04g03690	Function: the S. cerevisiae homolog Ste6p is a ABC-transporter similar to the human MDR transporter. Ste6p is responsible for transport of mating pheromone a-factor across the plasma membrane.; Induction: expression of STE6 is mating type dependent.; Similarity: shows strong similarity to several known and hypothetical ABC-type transporter proteins.; Title: strong similarity to mating pheromone transporter Ste6 - Saccharomyces cerevisiae; plasma membrane; See PMID 11294906
An04g03700	Title: strong similarity to hypothetical protein YPL225w - Saccharomyces cerevisiae
An04g03710	Title: similarity to hypothetical protein SPBC3E7.03c - Schizosaccharomyces pombe
An04g03720	Title: strong similarity to hypothetical protein SPAC6F6.17 - Schizosaccharomyces pombe
An04g03740	Title: weak similarity to ORF1557 polypeptide sequence SEQ ID NO:3114 from patent WO200058473-A2 - Homo sapiens
An04g03750	Title: strong similarity to hypothetical protein YMR099c - Saccharomyces cerevisiae
An04g03770	Title: strong similarity to hypothetical protein AAD34558.1 - Aspergillus terreus
An04g03780	Title: strong similarity to hypothetical membrane protein YJL057c - Saccharomyces cerevisiae
An04g03790	Title: strong similarity to hypothetical protein YNR053c - Saccharomyces cerevisiae
An04g03800	Title: weak similarity to hypothetical protein CAB51071.1 - Homo sapiens
An04g03810	Complex: TFB3 of S. cerevisiae is a subunit of the RNA polymerase II basal transcription factor TFIIH complex,that is composed also by the subunits TFB1, TFB2, TFB4,KIN28, RAD3, SSL1, SSL2, and CCL1.; Function: TFIIH is essential for transcription by RNA polymerase II and nucleotide excision DNA repair.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb3 - Saccharomyces cerevisiae; nucleus; See PMID 9774652; See PMID 10373527; See PMID 11007479
An04g03820	Remark: The lamprey is considered the most primitive living vertebrate and its neurofilaments (NFs) are unique in being homopolymers of a single 180 kDa subunit (NF-180); Title: weak similarity to NF-180 - Petromyzon marinus
An04g03830	Title: similarity to phorbol activated nuclear factor-like protein PNF1 from patent WO200162790-A2 - Homo sapiens
An04g03840	Title: similarity to microtubule binding protein D-CLIP-190 - Drosophila melanogaster; cytoskeleton
An04g03850	Title: strong similarity to hypothetical beta transducin-like protein het-e1 - Podospora anserina
An04g03860	Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH; Function: Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes,daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.; Title: similarity to carbonyl reductase NADPH -Rattus norvegicus
An04g03870	Similarity: the ORF shows similarity to the A. niger protein An11g05330. The similarity between the two proteins, however, is restricted to a stretch of about 100 amino acids.; Title: weak similarity to phosphatidic acid phosphatase ATPAP2 from patent WO200005385-A1 - Arabidopsis thaliana
An04g03890	Function: HxB is responsible for the insertion of the terminal sulphur atom in the molybdopterin cofactor.; Induction: HxB is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems.; Remark: the xanthine oxidase class of molybdoenzymes requires the molybdopterin cofactor (MoCF) to have a terminal, cyanolysable sulphur ligand.; Title: strong similarity to transulphurylase hxB -Aspergillus nidulans; See PMID 10096075; See PMID 11029694
An04g03900	Remark: alternate names in S. cerevisiae = YmL25,YGR076c.; Title: similarity to mitochondrial ribosomal protein of the large subunit Ymr26 - Saccharomyces cerevisiae; localisation:mitochondrion
An04g03910	Complex: Prp39p is uniquely associated with the U1 snRNP and is recruited with the U1 snRNP into splicing complexes.; Function: Prp39p is necessary for the stable interaction of mRNA precursors with the snRNP components of the pre-mRNA splicing machinery.; Title: strong similarity to pre-mRNA splicing factor Prp39 - Saccharomyces cerevisiae; nucleus; See PMID 8196608
An04g03920	Complex: U5-100kD is tightly associated with the U5 snRNP.; Function: U5-100kD is an RS domain-containing putative RNA helicase.; Function: U5-100kD potentially facilitates conformational changes in the spliceosome during nuclear pre-mRNA splicing.; Similarity: the C-terminal domain of U5-100kD shows significant homology to the S. cerevisiae splicing factor Prp28p.; Title: strong similarity to U5 snRNP 100 kD protein U5-100kD - Homo sapiens; nucleus; See PMID 9409622
An04g03930	Function: the aminopeptidase apsA from A. niger was found to be active towards a number of amino acid p-nitroanilide (pNA) substrates, viz. K-pNA, R-pNA, L-pNA,M-pNA, A-pNA and F-pNA.; Gene-ID: apsA; Remark: the most preferred N-terminal amino acid is lysine and not leucine,arginine or alanine, the N-terminal amino acids preferred by the yeast homologues.; See PMID 11495983
An04g03940	Function: MUP1 encodes the high affinity methionine permease from S. cerevisiae.; Function: MUP1 has also be shown to be a major permease in cysteine uptake.; Remark: MUP1 encodes an integral membrane protein with 13 putative membrane-spanning regions.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8893857; See PMID 11330701
An04g03950	Function: APG1 is a serine/threonine protein kinase involved in induction of autophagy after nutrient limitation.; Remark: S. cerevisiae imports cytosolic components into the vacuole non-selectively by autophagy and degrades them by vacuolar hydrolases under nutrient starvation conditions.; Remark: at least 15 APG genes are involved in autophagy in yeast.; Title: strong similarity to serine/threonine protein kinase Apg1 - Saccharomyces cerevisiae; See PMID 8224160; See PMID 9224897
An04g03960	Catalytic activity: SEC59 catalyzes the transfer of mannose to dolichol-linked oligosaccharide.; Function: SEC59 encodes a membrane protein required for core glycosylation in S. cerevisiae.; Phenotype: SEC59 mutants accumulate inactive and incompletely glycosylated forms of secretory proteins.; Title: similarity to dolichol kinase Sec59 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 2657387; See PMID 1323123
An04g03970	Remark: The EST sequence of EMBLEST:BE759313 is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to hypothetical protein SPAC577.12 - Schizosaccharomyces pombe
An04g03980	Function: MHY1 encodes a C(2)H(2)-type zinc finger protein with the ability to bind putative stress response elements and whose activity is essential for both hyphal and pseudohyphal growth in Y. lipolytica.; Function: Mhy1p may act as a transcription factor.; Induction: transcription of MHY1 is dramatically increased during the yeast-to-hypha transition in Yarrowia lipolytica.; Phenotype: Deletion of MHY1 is viable and has no effect on mating, but it does result in a complete inability of cells to undergo mycelial growth.; Title: similarity to C2H2-type zinc finger protein Mhy1p - Yarrowia lipolytica; nucleus; See PMID 10322005
An04g04000	Title: strong similarity to EST an_2710 -Aspergillus niger
An04g04040	Title: strong similarity to hypothetical thioredoxin SPAC577.08c - Schizosaccharomyces pombe
An04g04050	Title: similarity to hypothetical protein dnajp -Schizosaccharomyces pombe
An04g04060	Catalytic activity: 2 ferrocytochrome c + H(2)O(2) <=> 2 ferricytochrome c + 2 H(2)O.; Cofactor: heme; Function: protection against toxic peroxides.; Title: strong similarity to cytochrome-c peroxidase precursor Ccp1 - Saccharomyces cerevisiae
An04g04070	Similarity: the ORF shows weak similarity to anohter A. niger protein: An11g09200. The similarity between the two proteins, however, is restricted to a stretch of about 60 amino acids.; Title: weak similarity to hypothetical protein encoded by An11g09200 - Aspergillus niger
An04g04080	Title: similarity to hypothetical negative acting factor related protein - Neurospora crassa
An04g04100	Function: GTS1 gene product of S. cerevisiae appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle. a loss-of-function mutation results in a shortened unbudded period and smaller cell size, whereas overexpression of the GTS1 gene product extends the unbudded period and results in larger cells.; Title: strong similarity to Lsr1 - Saccharomyces cerevisiae; See PMID 8035831; See PMID 9046087; See PMID 9219336
An04g04110	Title: strong similarity to protein PIG-B - Mus musculus; See PMID 8861954
An04g04130	Catalytic activity: L-ornithine + a 2-oxo acid <=> L-glutamate 5-semialdehyde + an L-amino acid.; Cofactor: Pyridoxal-phosphate.; Title: strong similarity to ornithine-2-oxo-acid transaminase YLR438w - Saccharomyces cerevisiae
An04g04150	Remark: Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by a deficiency of the enzyme involved in the last step of tyrosine degradation,fumarylacetoacetate hydrolase (FAH). Thus far, 34 mutations in the FAH gene have been reported in various HT1 patients.; Title: strong similarity to fumarylacetoacetase -Homo sapiens; See PMID 10508789; See PMID 11154690; See PMID 11209059; See PMID 11262262; See PMID 11278491
An04g04160	Phenotype: mutations in S. cerevisiae Hol I are resposible for nonselective cation/histindiol uptake in S. cerevisiae.; Remark: Hol I is a member of the major facilitator superfamily (drug resistance subfamily) of transporters.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402
An04g04170	Catalytic activity: D-arabinitol + NAD(+) <=> D-ribulose + NADH.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis
An04g04210	Catalytic activity: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol <=> S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.; Cofactor: Glutathione.; Title: strong similarity to S-adenosyl-L-methionine:delta24-sterol-C-methyltransferase - Glycine max
An04g04240	Title: strong similarity to phosphate transport protein GvPT - Glomus versiforme
An04g04270	Title: similarity to hypothetical protein mlr1435 -Mesorhizobium loti
An04g04280	Remark: there is homology to a 5' EST an_3603 from A. niger.; Title: similarity to hypothetical protein SPBC800.14c - Schizosaccharomyces pombe
An04g04310	Remark: the ORF has an unusual exon/intron structure for A. niger.
An04g04320	Title: strong similarity to hypothetical protein encoded by An04g03250 - Aspergillus niger
An04g04330	Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: In soybean, 4CL isoenzymes possessing different substrate affinities for substituted cinnamic acids, and showing differential regulation to environmental stress, may play a pivotal role in distributing substituted cinnamate intermediates at a branch point of general phenylpropanoid metabolism into subsequent specific pathways.; Title: strong similarity to 4-coumarate-CoA ligase 4 4CL4 - Glycine max; See PMID 8278545
An04g04340	Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Remark: the lovF gene encodes an enzyme that is responsible for the biosynthesis of the (2R)-2-methylbutyryl side chain of lovastatin.; Title: strong similarity to nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 11386351
An04g04350	Title: similarity to hypothetical protein encoded by prophage CP-933X Z1925 - Escherichia coli
An04g04360	Title: similarity to hypothetical protein 104H10.250 - Neurospora crassa
An04g04370	Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Pathway: tyrosine metabolism; phenylalanine metabolism; nitrogen metabolism; alkaloid biosynthesis II.; Remark: the active sites of the enzyme phenylalanine ammonia-lyase (Pal) from Rhodosporidium toruloides contains a dehydroalanine residue that is believed to be essential for catalytic activity.; Similarity: belongs to the histidine ammonia-lyases.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides; See PMID 8200528; See PMID 1368015; See PMID 1773059
An04g04380	Remark: the terminal NRPS (non-ribosomal peptide synthetases) MxaA extends the assembled polyketide chain of the myxalamids with alanine. MxaA contains an N-terminal domain with homology to NAD binding proteins, which is responsible during the biogenesis for a novel type of reductive chain release giving rise to the 2-amino-propanol moiety of the myxalamids.; Similarity: belongs to the non-ribosomal peptide synthetase modules and related proteins.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319
An04g04390	Remark: activitie of pehA and of the eight enzymes involved in the catabolism of phthalate in Arthrobacter keyseri through protocatechuate to pyruvate and oxaloacetate were demonstrated in cells or cell extracts of recombinant E. coli strains.; Title: similarity to phthalate ester hydrolase pehA - Arthrobacter keyseri; See PMID 11371533
An04g04400	Remark: human telomeres are maintained by telomerase, a reverse transcriptase that adds telomeric repeats to chromosome ends. In human tumors and immortalized cells,telomeres are often maintained at a constant length setting, indicating that telomerase-mediated telomere elongation is tightly regulated. Tankyrase, a telomeric poly(ADP-ribose) polymerase (PARP), was identified through its interaction with TRF1, a negative regulator of telomere extension by telomerase.; Remark: similarity to Human tankyrase2 patent WO200100849-A1.; Title: similarity to tankyrase2 TANK2 from patent WO200100849-A1 - Homo sapiens; See PMID 11069113
An04g04430	Catalytic activity: digallate + H2O = 2 Gallate.; Remark: tannase consisted of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An04g04440	Remark: the mcr locus from Streptomyces lavendulae confers high level resistance (> 100 micrograms/ml) to mitomycin C (MC) and related mitomycins.; Remark: the predicted ORF shows similarity to oxidoreductases with different specificity.; Title: strong similarity to mcrA - Streptomyces lavendulae; See PMID 8917108
An04g04460	Title: strong similarity to hypothetical protein CAE47852.1/AfA24A6.020c - Aspergillus fumigatus
An04g04470	Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to NifA-regulated gene NrgA -Bradyrhizobium japonicum; See PMID 10692350
An04g04480	Remark: LovC Aspergillus terreus interacts with lovastatin nonaketide synthase (LNKS) and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An04g04490	Remark: grt1(+) defines an independent pathway that facilitates the function of Slp1.; Title: strong similarity to zinc-finger protein grt1p - Schizosaccharomyces pombe; See PMID 11058086
An04g04500	Remark: the human MUC3 is a large mucin glycoprotein expressed by the human intestine and gall bladder.; Similarity: the similarities of the ORF encoded protein to Muc1 from S. cerevisiae and the other proteins are mainly based on repetitive structures.; Title: similarity to ntestinal mucin MUC3 - Homo sapiens; See PMID 9334251
An04g04510	Remark: The jlbA mRNA formation in A. nidulans is elevated up to 40-fold upon amino acid starvation induced by the addition of the false feedback inhibitor 3-amino-1,2, 4-triazole.; Similarity: the ORF shows strong similarity to the A. niger EST an_2580.; Title: similarity to transcription factor jlbA -Aspergillus nidulans; nucleus; See PMID 11525406
An04g04520	Title: questionable ORF
An04g04530	Catalytic activity: endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan.; Pathway: aminosugars metabolism.; Remark: by endo-splitting activity, the chitosanase hydrolysed chitosan to form chitosan oligomers with chitotriose, chitotetraose and chitopentaose as the major products. The enzyme hydrolyses chitohexaose to form chitotriose, while the chitopentaose and shorter oligomers remain intact.; Title: strong similarity to chitosanase csnA -Aspergillus oryzae; See PMID 11055393; See PMID 11388486
An04g04540	Title: similarity to hypothetical protein YLR352w -Saccharomyces cerevisiae
An04g04570	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402
An04g04580	Similarity: the ORF shows strong similarity to the A. niger protein An11g05870. An11g05870, however, is much longer than the ORF (853 compared to 325 amino acids).; Title: strong similarity to hypothetical protein encoded by An11g05870 - Aspergillus niger
An04g04590	Title: strong similarity to hypothetical protein AAP25659.1 - Bacillus anthracis
An04g04610	Remark: the ORF is short in length (47 amino acids).
An04g04620	Title: strong similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger
An04g04630	Remark: the CAP59 gene is required for capsule formation. Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; See PMID 8007987
An04g04640	Catalytic activity: geranyl diphosphate + isopentenyl diphosphate = pyrophosphate + trans,trans-farnesyl diphosphate; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: the rice pathogen, Gibberella fujikuroi,produces large amounts of gibberellins, a group of natural plant hormones, which induce the superelongation (bakanae) disease of rice. Gibberellins are diterpenoid compounds which are synthesized via the isoprenoid pathway.; Similarity: belongs to the geranylgeranyl pyrophosphate synthases.; Title: strong similarity to geranylgeranyl diphosphate synthase GGSII - Gibberella fujikuroi; See PMID 9230902; See PMID 9917370
An04g04650	Similarity: the ORF shows weak similarity to the A. niger protein An16g00260. An16g00260, however, is much longer than the ORF (619 compared to 189 amino acids).; Title: weak similarity to hypothetical protein encoded by An16g00260 - Aspergillus niger
An04g04670	Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: expression of the CF/chitinase cDNA insert by using the pGEX-4T-3 vector yields a fusion peptide that bears CF-specific epitopes and shows chitinase activity.; Similarity: belongs to the chitinase family.; Title: strong similarity to chitinase cts1 -Coccidioides immitis; See PMID 8566773; See PMID 8675298
An04g04680	Remark: this ORF represents an putative FAD dependent monooxygenase.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to sequence 29 from patent WO0100842-A - Corynebacterium glutamicum
An04g04690	Remark: acr-2 gene controls acriflavine sensitivity in N. crassa. The acr-2 mutation, which confers acriflavine resistance, substitutes the amino acid residue at position 303 of the encoded protein from asparagine to lysine. Progeny that were hypersensitive to acriflavine were obtained by disruption of the acr-2 gene by repeat induced point mutation (RIP).; Similarity: belongs to the GAL4 zinc binuclear cluster proteins.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; nucleus; See PMID 8679704
An04g04700	Catalytic activity: S-adenosyl-L-methionine + catechol = S-adenosyl-L-homocysteine + guaiacol.; Pathway: tyrosine metabolism.; Remark: strong similarity to human catechol-O-methyltransferase patent WO9111513-A.; Remark: the mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.; Similarity: belongs to the SAM-dependent methyltransferases.; Title: strong similarity to catechol-O-methyltransferase COMT from patent WO9111513-A -Homo sapiens; See PMID 11154093; See PMID 1847521
An04g04710	Remark: paiB from B. subtilis is essential for growth.; Title: similarity to transcription regulator 2 of pai operon paiB - Bacillus subtilis; See PMID 2108124
An04g04720	Catalytic activity: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate.; Pathway: methionine metabolism; cysteine metabolism; selenoamino acid metabolism; nitrogen metabolism.; Remark: CYS3 is the structural gene for gamma-CTLase.; Similarity: similarity to other cystathionine gamma-lyases.; Title: strong similarity to cystathionine gamma-lyase - Saccharomyces cerevisiae; See PMID 8335636; See PMID 8511969
An04g04730	Title: weak similarity to retinitis pigmentosa GTPase regulator-like protein RPGR - Takifugu rubripes; See PMID 10932196
An04g04740	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An04g04750	Catalytic activity: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.; Function: the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-Coa & CO(2). it contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).; Pathway: citrate cycle (TCA cycle); lysine degradation; tryptophan metabolism.; Similarity: similarity to other oxoglutarate dehydrogenases.; Title: strong similarity to oxoglutarate dehydrogenase (lipoamide) Kgd1 - Saccharomyces cerevisiae; See PMID 2072900; See PMID 2503710; See PMID 8299151
An04g04770	Title: similarity to hypothetical protein CG6632 -Drosophila melanogaster
An04g04790	Remark: the CAP59 gene is required for capsule formation. Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; See PMID 8007987
An04g04800	Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to hypothetical protein SPAC1486.02c - Schizosaccharomyces pombe [truncated ORF]
An04g04810	Complex: TFB1 of S. cerevisiae is a subunit of the RNA polymerase II basal transcription factor TFIIH complex,that is composed also by the subunits TFB2, TFB3, TFB4,KIN28, RAD3, SSL1, SSL2, and CCL1.; Function: TFIIH is essential for transcription and nucleotide excision DNA repair.; Phenotype: S. cerevisiae TFB1 null mutants are inviable.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb1 - Saccharomyces cerevisiae; nucleus; See PMID 1445600; See PMID 10214907
An04g04820	Similarity: the ORF shows weak similarity to the A. niger protein:An01g07840. The ORF is much longer than An01g07840 (671 compared to 278 amino acids).; Similarity: the predicted ORF shows also weak local similarity with a putative nitrite reductase large subunit of Streptomyces coelicolor.; Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger
An04g04840	Title: strong similarity to hypothetical protein SPAC227.16c - Schizosaccharomyces pombe
An04g04850	Remark: truncated ORF due to end of contig.
An04g04860	Remark: it is used in the method of the invention which involves the use of a mutant cell with a nucleic acid construct introduced into a locus; the methods can be used for producing metabolites.; Remark: this is the nucleotide sequence of a rescued locus from the mutant Aspergillus oryzae DEBY1058.; Title: similarity to sequence 29 from patent WO9811203-A1 - Aspergillus oryzae
An04g04870	Catalytic activity: O2. - + O2. - + 2 H+ = O2 + H2O2.; Complex: homotetramer.; Function: destroys radicals which are normally produced within the cells and are toxic to biological systems.; Localization: mitochondrial matrix.; Remark: eukaryotic cells contain a mitochondrial Mn-containing enzyme and a cytoplasmic Cu-Zn containing enzyme.; Title: strong similarity to superoxide dismutase Sod2 - Saccharomyces cerevisiae
An04g04880	Title: strong similarity to tuftelin-interacting protein 39 - Mus musculus; See PMID 11063033
An04g04890	Catalytic activity: ATP + glycerol = ADP + glycerol 3-phosphate.; Pathway: rate limiting step in glycerol utilization.; Remark: glycerone and L-glyceraldehyde can act as acceptors; UTP can act as donors.; Title: strong similarity to glycerol kinase GK - Mus musculus
An04g04940	Title: similarity to EST SEQ ID NO:6012 from patent WO200056762-A2 - Aspergillus oryzae
An04g04950	Function: promotes endosomal cycling of TGN (trans-Golgi network) membrane proteins by modulating the function of two cytosolic TGN localization signals.; Remark: Null mutant is viable but exhibits defects in vacuolar protein sorting.; Title: strong similarity to vacuolar protein sorting-associated protein Vps13 - Saccharomyces cerevisiae; See PMID 11402063
An04g04970	Cofactor: the S. cerevisiae YAT11 binds and requires a zinc atom.; Function: the S. cerevisiae YAT11 is an ATP-dependent protease which causes an increased escape of DNA from mitochondria; and it is necessary to maintain the integrity of the mitochondrial compartment.; Function: the S. cerevisiae YAT11 is required both for the degradation of unassembled subunit 2 of cytochrome C oxidase and for efficient assembly of mitochondrial respiratory chain.; Similarity: the S. cerevisiae YAT11 belongs to the AAA family of ATPases.; Title: strong similarity to Yta11 - Saccharomyces cerevisiae
An04g04990	Catalytic activity: GTP + alpha-D-mannose 1-phoshate = diphosphate + GDP-mannose.; Function: mannose-1-phosphate guanyltransferase is involved in early steps of of protein glycosylation.; Title: strong similarity to mannose-1-phosphate guanyltransferase MPG1 - Trichoderma reesei; See PMID 9644208
An04g05000	Remark: protein AN80 is one of four new proteins discovered in A. nidulans that are essential for survival.; Title: strong similarity to hypothetical protein AN80 from patent WO9924580-A2 - Aspergillus nidulans
An04g05020	Title: questionable ORF
An04g05050	Title: questionable ORF
An04g05060	Domain: contains 37 finger motifs in 6 domains.; Function: binds RNA; could function in post-translational regulation processes.; Remark: belongs to the krueppel subfamily of C2H2-type zinc-finger proteins; phosphoprotein.; Title: similarity to protein XFIN - Xenopus laevis
An04g05090	Title: weak similarity to hypothetical secreted protein encoded by SCE41.06c - Streptomyces coelicolor
An04g05100	Localization: Subcellular localization studies of a tagged version of Gpi13 suggest that this protein is mainly in the ER.; Phenotype: Gpi13-depleted S. cerevisiae cells accumulate GPI intermediates with the structures Manalpha1-2Manalpha1-2Manalpha1-6[NH(2)-(CH(2))(2)-PO(4)-- >]Manalpha1 -4GlcNalpha1-6[acyl-->]inositol-PO(4)-lipid and Manalpha1-2Manalpha1-2Manalpha1-6Manalpha1-4G lcNalpha1-6[acyl-->]inositol-PO(4)-lipid.; Phenotype: depletion of Gpi13 from S. cerevisiae results in a reduction of glycosylphosphatidylinositol (GPI) anchor addition to GPI proteins as well as in cell wall fragility.; Remark: the synonym for Gpi13 from S. cerevisiae is YLL031c.; Similarity: Gpi13 is a member of a family of phosphoryltransferases,; Title: strong similarity to protein involved in glycosylphosphatidylinositol biosynthesis Gpi13 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10793139; See PMID 10823837
An04g05110	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:12845 from patent EP1033405-A2 - Arabidopsis thaliana
An04g05120	Title: strong similarity to hypothetical protein CAB91749.2 - Neurospora crassa
An04g05130	Catalytic activity: Aspartate + 2-Oxoglutarate = Oxaloacetate + Glutamate.; Cofactor: Pyridoxal phosphate.; Remark: The matched protein sequence of patent WO9729187-A1 comprises aspartate aminotransferase VF5/AA of Aquifex VF5, a strictly chemolithoautotrophic marine eubacterium which grows optimally at 85-90 deg C and pH 6. 8 in high salt medium.; Title: strong similarity to aspartate aminotransferase VF5 from patent WO9729187-A1 - Aquifex sp.
An04g05150	Complex: the S. pombe proteins scd1, scd2, cdc42,and ras1, in its GTP-bound state, act cooperatively to form a protein complex.; Function: scd1 from S. pombe is a regulator of the Cdc42 GTPase.; Function: scd1 from S. pombe is required for mating and morphogenesis.; Localization: scd1 from S. pombe localizes in the nucleus.; Phenotype: loss of function in scd1 from S. pombe induced abnormality in the spindle.; Similarity: to other guanine-nucleotide releasing factors of the Cdc24 family.; Title: strong similarity to guanine nucleotide exchange factor scd1p - Schizosaccharomyces pombe; nucleus; See PMID 9892665; See PMID 7923372
An04g05160	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens
An04g05180	Function: transient over-expression of human delta-beta-TrCP (a deletion mutant) inhibited the degradation of endogenous I-kappa-B-alpha in stimulated Jurkat cells, resulting in accumulation of phosphorylated I-kappa-B-alpha.; Remark: E3 enhances ubiquitination of phosphorylated I-kappa-B, an inhibitor protein of nuclear factor kappa-B (NF-kappa-B).; Remark: human beta-TrCP can be used to modulate NF-kappa-B to treat inflammatory diseases, autoimmune diseases, cancer and viral infections.; Similarity: human beta-TrCP is an F-box/WD protein family member and shows homology to human E3 ubiquitin ligase (E3).; Title: strong similarity to E3 ubiquitin ligase beta-TrCP from patent WO200034447-A2 - Homo sapiens; See PMID 10437795
An04g05190	Title: weak similarity to pancreatic islet homeobox gene Nkx6.1 - Homo sapiens
An04g05200	Title: weak similarity to protein fragment SEQ ID NO:3484 from patent EP1033405-A2 - Arabidopsis thaliana
An04g05210	Remark: Feline leukemia virus-C (FeLV-C) causes red cell aplasia in cats, through its interaction with its cell surface receptor FLVCR1.; Similarity: FLVCR1 from F. catus is a member of the major facilitator superfamily of transporters and shows homologies especially to D-glucarate transporters.; Title: strong similarity to feline leukemia virus subgroup C receptor FLVCR1 - Felis catus; See PMID 10648427
An04g05220	Catalytic activity: QH2 + 2 Ferricytochrome c = Q + 2 Ferrocytochrome c; Cofactor: Cytochrome b-562, Cytochrome b-566,Cytochrome c1, 2-Iron ferredoxin.; Complex: Qcr6 from S. cerevisiae is one of the components of the complex III or cytochrome b-c1 complex.; Function: qcr6 null mutant of S. cerevisiae is blocked in processing of cytochrome c1 to mature size.; Phenotype: qcr6 null mutant of S. cerevisiae can grow on nonfermentable carbon sources, but has half of the normal ubiquinol cytochrome-c reductase activity.; Remark: synonyms for Qcr6 from S. cerevisiae are Ucr6, Cor3 and YFR033c.; Title: strong similarity to subunit 6 of ubiquinol--cytochrome-c reductase Qcr6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8288589; See PMID 2170363
An04g05230	Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:2344 from patent EP1033405-A2 - Arabidopsis thaliana
An04g05250	Function: the cis-prenyltransferase Rer2 from S. cerevisiae is a key enzyme of the dolichol synthesis.; Phenotype: the rer2 mutant of S. cerevisiae shows slow growth, defects in N and O glycosylation, sensitivity to hygromycin B, and abnormal accumulation of membranes,including the ER and the Golgi membranes.; Phenotype: the temperature-sensitive rer2 mutant of S. cerevisiae mislocalizes different types of ER membrane proteins.; Remark: Dolichol is a family of long-chain polyprenols, which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum.; Remark: the synonym for Rer2 from S. cerevisiae is YBR002c.; Title: strong similarity to undecaprenyl phosphate synthase Rer2 from patent WO200121650-A2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9858571
An04g05260	Catalytic activity: N6-(L-1,3-Dicarboxypropyl)-L-lysine + NADP+ + H2O = L-Glutamate + L-2-Aminoadipate 6-semialdehyde + NADPH.; Complex: saccharopine reductase from M. grisea is a homodimer.; Function: saccharopine reductase from M. grisea is an enzyme of the alpha-aminoadipic pathway of lysine biosynthesis.; Similarity: the ORF also shows strong similarity to the EST SEQ ID NO:6253 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to saccharopine reductase LYS3 - Magnaporthe grisea; See PMID 10771443; See PMID 11080625
An04g05270	Function: Adr1 from S. cerevisiae is a zinc-finger transcription factor and involved in regulation of ADH2 and peroxisomal genes.; Remark: a splice site was detected upstream of the START codon.; Remark: the synonym for Adr1 from S. cerevisiae is YDR214w.; Repression: Adr1 from S. cerevisiae is inactivated by phosphorylation at Ser230 by protein kinase A.; Title: strong similarity to transcription activator Adr1 - Saccharomyces cerevisiae; nucleus; See PMID 9742103; See PMID 1427033; See PMID 6341814
An04g05280	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An04g05290	Title: questionable ORF
An04g05300	Catalytic activity: D-Fructose 1,6-bisphosphate + H2O = D-Fructose 6-phosphate + Orthophosphate.; Catalytic activity: Sedoheptulose 1,7-bisphosphate + H2O = Sedoheptulose 7-phosphate + Orthophosphate.; Repression: Expression of fbpA from A. oryzae is repressed in the presence of glucose, but not in the presence of pyruvate or sodium acetate in the medium.; Title: strong similarity to fructose-1,6-bisphosphatase fbpA - Aspergillus oryzae; See PMID 10993168
An04g05310	Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Complex: Vph1-containing complexes in S. cerevisiae present in the vacuole showed dissociation in response to glucose depletion.; Localization: Vph1p is a vacuolar integral membrane protein.; Phenotype: Deletion of the VPH1 from S. cerevisiae gene revealed that the VPH1 gene is not essential for viability but is required for vacuolar H(+)-ATPase assembly and vacuolar acidification.; Remark: the synonym for Vph1 from S. cerevisiae is YOR270c.; Similarity: the ORF also shows strong similarity to the EST an_2746 from Aspergillus niger.; Title: strong similarity to vacuolar H(+)-transporting ATPase subunit Vph1 - Saccharomyces cerevisiae; vacuole; See PMID 11278748; See PMID 1385813
An04g05320	Title: strong similarity to hypothetical protein TEMO - Rattus norvegicus
An04g05330	Title: strong similarity to hypothetical protein SPAC18B11.05 - Schizosaccharomyces pombe
An04g05350	Similarity: weak similarities due to multiple serine and glycine repeats.
An04g05360	Remark: a splice site was detected upstream of the START codon.; Similarity: similarities correspond to multiple serine repeats.; Title: weak similarity to dentin sialophosphoprotein from patent WO200062065-A1 - Homo sapiens
An04g05370	Title: questionable ORF
An04g05380	Remark: C. albicans 6C5 protein is also useful in diagnostic tests (i. e. detect, diagnose and serotype yeast infection), and for detecting the presence of Candida and other pathogenic yeasts, in a biological sample.; Remark: the C. albicans 6C5 antigen is a hydrophobic cell wall protein that, together with the corresponding antibody, can be used to diagnose and treat infections with pathogenic yeasts.; Similarity: similarities to oxidoreductases involved in carbohydrate-utilization resp. energy generation.; Title: strong similarity to cell wall antigen 6C5 from patent WO200048620-A1 - Candida albicans
An04g05390	Similarity: similarities correspond to multiple serine repeats.; Title: weak similarity to hypothetical protein PFB0700c - Plasmodium falciparum
An04g05420	Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Complex: the aminoadipate reductase enzyme is a heterodimer of a large (lys2) and a small subunit.; Function: lys2 of P. chrysogenum, as well as of S. cerevisiae, catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Pathway: lysine biosynthesis.; Remark: disruption of P. crysogenum lys2 leads to mutants lacking alpha-aminoadipate reductase activity,showing penicillin yields double those of the parental nondisrupted strain.; Title: strong similarity to alpha-aminoadipate reductase large subunit lys2 - Penicillium chrysogenum; See PMID 9790587; See PMID 9973344; See PMID 10485291
An04g05430	Title: strong similarity to hypothetical protein CAD21051.1 - Neurospora crassa
An04g05440	Catalytic activity: xanthine + H(2)O + O(2) = urate + H(2)O(2).; Catalytic activity: xanthine + NAD(+) + H(2)O = urate + NADH.; Cofactor: FAD, molybdopterin, and two 2fe-2s centers.; Complex: homodimer.; Function: Xanthine dehydrogenase is a molybdenum iron-sulphur flavin hydroxylase which oxidizes a variety of purines, pterins and other heterogenic nitrogen compounds,serving as a rate-limiting enzyme in nucleic acid degradation.; Pathway: purine catabolism; Remark: Xanthine dehydrogenase can be converted from the dehydrogenase form (d) to the oxidase form (o) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.; Remark: Xanthine dehydrogenase contains four cofactors per subunit, one FAD, two iron-sulfur clusters,and one molybdopterin.; Remark: Xanthine dehydrogenase is reversibly converted to xanthine oxidase by oxidized glutathione catalyzed by enzyme-thiol transhydrogenase (oxidized-glutathione) (EC 1. 8. 4. 7).; Remark: the reversible conversion to xanthine oxidase can also be performed artificially by a variety of sulfhydryl reagents. An irreversible conversion can be performed by limited proteolysis.; Title: strong similarity to xanthine dehydrogenase XDH - Homo sapiens; See PMID 8135849
An04g05450	Similarity: the ORF shows strong similarity to the A. niger protein An09g05620. However, the ORF is much longer than the other An09g05620 (650 compared to 152 amino acids).; Title: similarity to hypothetical protein encoded by An09g05620 - Aspergillus niger
An04g05460	Title: strong similarity to hypothetical membrane protein YNL279w - Saccharomyces cerevisiae
An04g05480	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An04g05490	Similarity: similarities to pro- and eukaryotic aminotransferases.; Title: strong similarity to protein fragment SEQ ID NO:4306 from patent EP1033405-A2 - Arabidopsis thaliana
An04g05500	Remark: the WHIP protein of M. musculus interacts with the N-terminal portion of Werner protein (WRN),containing the exonuclease domain.; Remark: the WHIP protein of M. musculus shows homology to replication factor C family proteins, conserved from E. coli to human.; Title: strong similarity to Werner helicase interacting protein WHIP - Mus musculus; See PMID 9271578; See PMID 9671747; See PMID 10938117; See PMID 11301316
An04g05510	Function: the cell division cycle gene CDC31 of S. cerevisiae is required for spindle pole body duplication.; Remark: the calcium-binding CDC31 protein of S. cerevisiae defines a substructure of spindle pole body.; Title: strong similarity to cell division control protein Cdc31 - Saccharomyces cerevisiae; nucleus; See PMID 8408222; See PMID 2839516
An04g05520	Title: questionable ORF
An04g05530	Function: the ADAM19 metalloproteinase of H. sapiens belongs to the adamalysin protein family and is involved in proteolysis, adhesion, fusion, and intracellular signaling.; Title: similarity to disintegrin and metalloproteinase ADAM19 - Homo sapiens; cytoplasm; See PMID 10753657; See PMID 11162584
An04g05540	Remark: the iota polymerase of H. sapiens is able to facilitate limited translesion replication of a thymine-thymine cyclobutane pyrimidine dimer.; Title: strong similarity to DNA polymerase iota POLI - Homo sapiens; nucleus
An04g05550	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An04g05560	Title: similarity to protein fragment SEQ ID NO:1213 from patent EP1033405-A2 - Arabidopsis thaliana
An04g05570	Similarity: similarities correspond only to the C-terminal region.; Title: similarity to cellular proliferation protein #830 from patent WO200170955-A2 - Staphylococcus aureus
An04g05580	Remark: 5'-truncated ORF due to contig-border.; Title: similarity to hypothetical protein B5O22.140 - Neurospora crassa [truncated ORF]
An04g05590	Remark: blastp matches are unspecific; Title: weak similarity to hypothetical protein WP6 -Chlamydomonas eugametos
An04g05620	Catalytic activity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.; Function: acetate--CoA ligase catalyzes the formation of acetyl-CoA from acetate and CoA.; Induction: by acetate.; Title: strong similarity to acetate--CoA ligase facA - Aspergillus nidulans; see citation in PMID 1972535; see citation in PMID 11255012
An04g05630	Function: the GLFG region of S. cerevisiae Nup100p directly binds the essential mRNA export factors Mex67 and Gle1.; Function: the GLFG region of S. cerevisiae Nup100p directly binds the protein import factor Kap95p.; Title: similarity to nuclear pore complex subunit Nup100 - Saccharomyces cerevisiae; nucleus; see citation in PMID 8848052; see citation in PMID 1385442; see citation in PMID 10684247; see citation in PMID 11104765
An04g05640	Catalytic activity: ubiquinone oxidoreductase converts NADH + ubiquinone to NAD(+) + ubiquinol.; Function: A. niger NUO51 is part of complex I of the mitochondrial respiratory chain.; Gene-ID: nuo51; localisation:mitochondrion
An04g05650	Title: strong similarity to hypothetical protein SPBC1709.13c - Schizosaccharomyces pombe
An04g05660	Complex: S. cerevisae SAP190 physically associates with SIT4, the catalytic subunit of a type 2A-related protein phosphatase.; Function: S. cerevisae SAP190 acts via SIT4, the catalytic subunit of a type 2A-related protein phosphatase.; Function: S. cerevisae SAP190, in redundance with SAP185, is required for bud formation.; Regulation: S. cerevisae SAP190 is not functional in the absence of SIT4 and likewise, SIT4 is not functional in the concomitant absence of SAP190 and SAP185.; Title: strong similarity to bud formation factor Sap190 - Saccharomyces cerevisiae; see citation in PMID 8649382
An04g05670	Complex: S. cerevisiae Vps24p and Vps32p/Snf7p form a complex with a Vps4p decamer.; Function: S. cerevisiae Snf7p is involved in endosome to vacuole transport.; Remark: alternative names for S. cerevisiae SNF7 are DID1 and Vps32.; Title: similarity to vacuolar sorting protein Snf7 -Saccharomyces cerevisiae; endosome; see citation in PMID 8224817; see citation in PMID 9606181; see citation in PMID 11251082
An04g05680	Function: genetically S. cerevisiae SMF1 is implicated in Cu(2+), Mn(2+), Co(2+) and Cd(2+) homeostasis and, eventually, Fe(2+) uptake.; Function: in Xenopus oocyte assays S. cerevisiae SMF1 mediates H(+)-dependent Fe(2+) transport and uncoupled Na(+), Li(+), Rb(+), K(+) and Ca(2+) flux.; Regulation: S. cerevisiae BSD2 negatively controls metal transport by SMF1, targeting it to the vacuole where it is degraded.; Remark: the PIR entry of S. cerevisiae YOL122c incorrectly contains the gene name ESP1, however, the gene is named SMF1, an alias is SBS1.; Title: strong similarity to metal transporter Smf1 -Saccharomyces cerevisiae; plasma membrane; see citation in PMID 8643535; see citation in PMID 911523; see citation in PMID 10574989; see citation in PMID 10930410; see citation in PMID 11027260
An04g05700	Function: human SRL300 was isolated due to its ability to bind the 5'-noncoding sequence of the ATBF1 mRNA.; Title: similarity to RNA-binding protein SRL300 -Homo sapiens; see citation in PMID 11004489
An04g05710	Title: weak similarity to hypothetical protein CAE75710.1 - Neurospora crassa
An04g05720	Catalytic activity: Acetyl-CoA C-acyltransferases convert Acyl-CoA + acetyl-CoA to CoA + 3-oxoacyl-CoA.; Function: Y. lipolytica POT1 is involved in fatty acid utilisation.; Localization: Y. lipolytica POT1 belongs to the peroxisomal rather than the mitochondrial or cytoplasmic class of thiolases.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3019 and 0468.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; see citation in PMID 7916689
An04g05730	Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Title: similarity to inhibitor of endosome-lysosome fusion DotA - Legionella pneumophila; endosome; see citation in PMID 9632267; see citation in PMID 11207624
An04g05740	Catalytic activity: arylamine N-acetyltransferase catalyzes the N-acetylation of arylamines by acetyl-CoA.; Function: humna NAT1, together with NAT2,N-acetylates and detoxifies aromatic amines, but also activates their N-hydroxylated metabolites by O- and N,O-acetylation to unstable acetoxy intermediates which decompose to electrophiles, bind to DNA, and lead to mutagensis and carcinogenesis.; Title: similarity to arylamine N-acetyltransferase NAT1 - Homo sapiens; see citation in PMID 2340091
An04g05750	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3194 and Nig024.; Title: strong similarity to hypothetical protein EAA71297.1 - Gibberella zeae [putative sequencing error]
An04g05760	Complex: human HBO1 exists as part of a multisubunit complex that possesses histone H3 and H4 acetyltransferase activities.; Complex: human HBO1 interacts with the androgen receptor (AR), a member of the nuclear receptor superfamily.; Function: HBO1 is part of the histone H3 and H4 acetyltransferase but also specifically repressed androgen receptor mediated transcription.; Similarity: human HBO1 is a member of the MYST domain family; Similarity: similarity is from the central region of the predicted A. niger protein to human HBO1, which is 400 aa shorter.; Title: similarity to histone acetyltransferase HBO1 - Homo sapiens; nucleus; see citation in PMID 10438470; see citation in PMID 10839822; see citation in PMID 10930412
An04g05770	Title: weak similarity to transcription activator VP1 - Triticum aestivum; see citation in PMID 11413225
An04g05780	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An04g05790	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and glutamine rich proteins.; Title: questionable ORF
An04g05800	Title: similarity to hypothetical protein CAC37374.1 - Schizosaccharomyces pombe
An04g05810	Function: S. pombe rad8 mutant is sensitive to both UV and gamma irradiation.; Similarity: S. pombe rad8 is a member of the SNF2 helicase family.; Similarity: similarity is between two regions, each ~ 100 aa, in the N- and C-terminal half of the predicted A. niger protein and S. pombe rad8.; Title: similarity to DNA repair protein rad8p -Schizosaccharomyces pombe
An04g05820	Function: C. albicans Rfg1 is a transcriptional regulator controling filamentous growth and virulence.; Similarity: similarity is between regions of ~ 100 aa in the N-terminal halfs of the predicted A. niger protein and C. albicans Rfg1.; Title: similarity to transcription regulator Rfg1 -Candida albicans; see citation in PMID 11259598
An04g05830	Similarity: similarity is between the predicted A. niger protein and the N-terminal half of T. curvata aglA,which is 400 aa longer.; Title: weak similarity to thermotolerant alpha-1,4-glucosidase aglA - Thermomonospora curvata; see citation in PMID 10792537
An04g05840	Title: weak similarity to phospholipid-cholesterol acyltransferase - Aeromonas hydrophila; see citation in PMID 3280033
An04g05850	Remark: S. pombe rps6 is transcribed into three distinct transcripts with different sizes and heterogeneous termini.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2975 and 3307 (in the 5'UTR).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit rps6p - Schizosaccharomyces pombe; cytoplasm; see citation in PMID 2834104
An04g05860	Catalytic activity: ribose-phosphate pyrophosphokinases convert ATP + D-ribose 5-phosphate to AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Complex: by genetic interaction and two-hybrid PRS family members form functional complexes, e. g. PRS2 with PRS5.; Function: S. cerevisiae phosphoribosyl-pyrophosphate (PRPP) is required for purine, pyrimidine, tryptophan and histidine biosynthesis.; Function: in S. cerevisiae disruption of PRS1 or PRS3 has a significant effect on cell metabolism, whereas disruption of PRS2 or PRS4 has little measurable effect.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3596.; Remark: the PRS gene family in S. cerevisiae consists of five genes each capable of encoding a 5-phosphoribosyl-1(alpha)-pyrophosphate synthetase polypeptide.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prs2 - Saccharomyces cerevisiae; see citation in PMID 7992503; see citation in PMID 9108276; see citation in PMID 10212224
An04g05870	Complex: by two-hybrid S. cerevisiae TOM1 interacts with KRR1, which is involved in nucleolar 40S ribosome biogenesis.; Function: S. cerevisiae TOM1 is a E3 ubiquitin ligase involved in hnRNP protein localization and thereby affecting specificity of nuclear mRNA export.; Function: S. cerevisiae strains with mutant alleles of TOM1 are defective in multiple steps in rRNA processing.; Function: in S. cerevisiae, several different hnRNP adaptors for mRNA export exist and TOM1 regulates the localisation of e. g. Nab2p but not Np13p.; Title: strong similarity to E3 ubiquitin ligase Tom1 - Saccharomyces cerevisiae; see citation in PMID 10395901; see citation in PMID 10873801; see citation in PMID 11027267; see citation in PMID 11238398
An04g05880	Catalytic activity: linoleate diol synthase catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate.; Complex: linoleate diol synthase is a homotetrameric ferric hemeprotein.; Function: linoleate diol synthase is involved in the dioxygenation of polyunsaturated fatty acids; Title: strong similarity to linoleate diol synthase - Gaeumannomyces graminis; see citation in PMID 10497176
An04g05900	Title: strong similarity to reverse transcriptase pol - Volvox carteri; see citation in PMID 7681411
An04g05930	Complex: S. cerevisiae Tsc13p coimmunoprecipitates with Elo2p and Elo3p, which are also involved in very long chain fatty acid synthesis.; Function: S. cerevisiae TSC13 is required for elongation of the palmitate, produced by cytosolic fatty acid synthase, by two carbon units.; Function: S. cerevisiae TSC13 possibly is the enoyl reductase that catalyzes the last step in each cycle of fatty acid elongation.; Function: S. cerevisiae tsc13 mutant accumulates high levels of long-chain bases as well as ceramides that harbor fatty acids with chain lengths shorter than 26 carbons.; Localization: S. cerevisiae TSC13 localizes to a novel endoplasmic reticulum structure at the nuclear-vacuolar interface.; Title: strong similarity to very long chain fatty acid synthase Tsc13 - Saccharomyces cerevisiae; endoplasmatic reticulum; see citation in PMID 11113186
An04g05940	Function: gma12p is not the only galactosyltransferase in S. pombe, but it produces a unique carbohydrate structure on the surface of the yeast cells.; Golgi; Localization: electron microscopic localization revealed that gma12p synthesizes the carbohydrate structure in the Golgi apparatus.; Title: strong similarity to alpha 1,2 galactosyltransferase gma12p - Schizosaccharomyces pombe; see citation in PMID 7522655
An04g05950	Remark: alternative names for S. cerevisiae MRPL24 are YML14, YML24 and YMR193W.; Remark: of the ~50 MRPs isolated in S. cerevisiae (until 1998) only a minority show significant sequence similarities to known ribosomal proteins from other sources.; Similarity: the predicted A. niger protein is 80 aa longer than S. cerevisiae MRPL24 and might use a wrong startcodon.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L24 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 9151978; see citation in PMID 9445368
An04g05960	Complex: rat TIP49a binds to TIP49b, which is a 5' to 3' DNA-helicase, TBP and RNA-pol II.; Function: rat TIP49a ATPase activity is stimulated by single-stranded DNA but neither by double-stranded DNA nor by any forms of RNA polymers tested.; Function: rat TIP49a is a DNA-helicase unwounding dsDNA in the 3' to 5' direction with respect to the single-stranded DNA flanking the duplex.; Title: strong similarity to DNA-helicase TIP49a -Rattus norvegicus; nucleus; see citation in PMID 9196036; see citation in PMID 10336418; see citation in PMID 10428817; see citation in PMID 10787406
An04g05970	Function: the cyclopropane synthase from Sterculia foetida produces dihydrosterculate from oleate and uses S-adenosylmethionine as the methylene donor.; Similarity: the predicted A. niger protein contains FAD- and NADH-binding motifs of pyridine nucleotide-disulphide deoxygenases.; Title: similarity to cyclopropane synthase AAM33848.1 - Sterculia foetida; see citation in PMID 11997456
An04g05980	Complex: S. cerevisiae Vti1p interacts with the t-SNAREs Sed5p, Pep12p, Vam3p and Vam7p, the v-SNAREs Nyv1p and Ykt6p and the SNAP Sec17p.; Function: S. cerevisiae Vti1p acts as a retrograde v-SNARE and interacts directly with the t-SNARE Sed5p to target retrograde vacuole to cis-Golgi traffic.; Function: in S. cerevisiae the transport vesicle specivic v-SNARE Vti1p interacts with the prevacuolar target specific t-SNARE Pep12p to direct Golgi to prevacuolar traffic.; Function: in S. cerevisiae vacuole-vacuole fusion requires a cis-SNARE complex of five SNAREs, the t-SNAREs Vam3p and Vam7p and the v-SNAREs Nyv1p, Vti1p, and Ykt6p.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2635, 2436 and 2514.; Title: strong similarity to v-SNARE Vti1 -Saccharomyces cerevisiae; intracellular transport vesicles; see citation in PMID 9199167; see citation in PMID 9398683; see citation in PMID 10385523
An04g05990	Title: similarity to hypothetical protein B23I11.280 - Neurospora crassa
An04g06000	Function: S. cerevisiae PUT3 is a positive regulator of PUT (proline utilization) genes.; Similarity: S. cerevisiae PUT3 is a zinc finger transcription factor with a fungal GAL4-type Zn(2)-Cys(6) binuclear cluster domain.; Similarity: similarity is between the predicted A. niger protein and the C-terminal 2/3s of S. cerevisiae PUT3, which is 300 aa longer.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; nucleus; see citation in PMID 2689861
An04g06010	Title: similarity to mitomycin biosynthesis protein MmcH from patent WO200053737-A2 - Streptomyces lavendulae
An04g06020	Function: S. cerevisiae ISA1 is involved in the assembly of Fe/S-clusters in mitochondrial and cytoplasmatic proteins.; Localization: S. cerevisiae ISA1 localises to the mitochondrial matrix.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3349 .; Title: strong similarity to mediator of mitochondrial Fe/S-cluster assembly Isa1 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 10748136; see citation in PMID 10805735; see citation in PMID 10913600
An04g06030	Title: strong similarity to hypothetical protein SPBC20F10.02c - Schizosaccharomyces pombe
An04g06040	Function: S. cerevisiae EAF3 is component of the NuA4 histone-acetyltransferase complex, however eaf3 mutations are viable and have no growth phenotype.; Function: S. pombe alp13 mutants are temperature-sensitive, have cell polarity defects and are sterile.; Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted A. niger protein shows strong similarity to alp13 of S. pombe (also known as chromo domain protein), which belongs to the MRG protein family. MRG proteins comprise the homologous proteins human MORF4 related gene, D. melanogaster male specific lethal-3 (Msl-3) and S. cerevisiae Eaf3p.; Title: strong similarity to cell polarity determinant alp13p - Schizosaccharomyces pombe; see citation in PMID 9658169; see citation in PMID 11036083
An04g06050	Title: strong similarity to hypothetical protein SPAC23H4.11c - Schizosaccharomyces pombe
An04g06060	Complex: S. cerevisiae Ctf8p interact physically with Ctf18p, Dcc1p, Rfc2p, Rfc3p, Rfc4p and Rfc5p but not with Rfc1p or Rad24p.; Function: S. cerevisiae Ctf8p forms part of an alternative replication factor complex (RFC) involved in sister chromatid cohesion and faithful chromosome transmission.; Function: deletion of S. cerevisiae CTF8 leads to a severe sister chromatid cohesion defect.; Remark: the systematic name for S. cerevisiae CTF8 is YHR191c.; Title: similarity to replication factor complex subunit Ctf8 - Saccharomyces cerevisiae; nucleus; see citation in PMID 11389843
An04g06070	Title: strong similarity to EST an_1548 -Aspergillus niger
An04g06080	Complex: human GAPCenA interacts with Rab6,cytosolic gamma-tubulins and is associated with the centrosome.; Function: human GAPCenA is a GAP specifically active in vitro on Rab6, which regulates intracellular transport at the level of the Golgi, and, to a lesser extent, on Rab4 and Rab2 proteins.; Function: human GAPCenA may be involved in the coordination of microtubule and Golgi dynamics during the cell cycle.; Function: human GAPCenA was found to form complexes with cytosolic gamma-tubulin and to play a role in microtubule nucleation.; Localization: immunofluorescence and cell fractionation experiments showed that human GAPCenA is mainly cytosolic but that a minor pool is associated with the centrosome.; Title: similarity to Rab6 GTPase activating protein GAPCenA - Homo sapiens; see citation in PMID 10202141
An04g06090	Function: S. cerevisiae BET4 is required for the prenylation of Rab GTP-binding proteins which leads to their membrane attachment and subsequent activity in the regulation of vesicular traffic.; Title: similarity to geranylgeranyltransferase type-II alpha chain Bet4 - Saccharomyces cerevisiae; see citation in PMID 8756702
An04g06100	Complex: human CDC20 binds to APC, a hMAD2 tetramer,cyclin A, BUBR1 and the kinase aurora2/Aik.; Function: activation of the anaphase-promoting complex (APC) by binding of human CDC20 in metaphase and CDH1 in telophase is required for anaphase and for exit from mitosis.; Function: the human checkpoint protein hMAD2 prevents activation of APC by forming a hMAD2-CDC20-APC complex.; Regulation: the phosphorylation of Cdc20 by Cdc2-Cyclin B and cyclinA-cyclin A-associated kinase influences activity of the CDC20-APC complex.; Remark: an alternative name for human CDC20 is p55CDC.; Similarity: similarity is from the central region of the predicted A. niger protein to human CDC20, which is 400 aa shorter.; Title: similarity to cell cycle protein CDC20 - Homo sapiens; nucleus; see citation in PMID 7513050; see citation in PMID 9637688; see citation in PMID 10377410; see citation in PMID 10459014; see citation in PMID 10679238
An04g06110	Remark: blastp with the predicted A. niger protein only retrieves random hits to threonine rich proteins.
An04g06120	Similarity: the ORF shows also strong similarity to EST EMBLEST:BE759148 an_3476 from Aspergillus niger.; Title: strong similarity to hypothetical protein YDR398w - Saccharomyces cerevisiae
An04g06130	Title: weak similarity to transcription factor SoxP1 - Oncorhynchus mykiss; see citation in PMID 8543013
An04g06140	Function: S. cerevisiae BDF1 is transcription factor involved in control of snRNA expression.; Function: in S. cerevisiae most cells from the bdf1 null mutant fail to undergo one or both meiotic divisions,and there is an absolute defect in spore formation.; Similarity: S. cerevisiae BDF1 contains two bromodomains.; Title: similarity to transcription factor Bdf1 -Saccharomyces cerevisiae; nucleus; see citation in PMID 7791775; see citation in PMID 7816623
An04g06150	Function: S. cerevisiae DPH gene products catalyse the post translational modification of a histidine residue in translation elongation factor-2 (EF-2) to a diphthamide residue.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal region of S. cerevisiae DPH3.; Title: weak similarity to DPH3 from patent WO9953762-A1 - Saccharomyces cerevisiae
An04g06160	Function: S. cerevisiae frataxin (YFH1) is necessary for FeS cluster assembly into ferredoxin.; Function: S. cerevisiae yfh1 mutations are highly sensitive to oxidants, such as H2O2, iron and copper and their mitochondria contain 10 times more iron than wild-type.; Function: expansion of GAA repeats in human frataxin causes Friedreich's ataxia, an autosomal recessive,degenerative disease of central and peripheral nervous systems and the heart.; Title: strong similarity to mitochondrial frataxin Yfh1 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 8596916; see citation in PMID 9241270; see citation in PMID 9271239; see citation in PMID 11273703
An04g06170	Title: similarity to hypothetical protein B7N4.10 -Neurospora crassa
An04g06180	Complex: Sec6p of S. cerevisiae and six other proteins (Sec15p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) together form the exocyst complex.; Function: S. cerevisiae Sec6 is a cytoplasmic protein involved in the last step of the secretory pathway,the fusion of post-Golgi vesicles with the plasma membrane.; Function: S. cerevisiae Sec6 is a subunit of the Exocyst complex, which is required for exocytosis.; Localization: the exocyst of S. cerevisiae is found in the cytoplasm and associated with the plasma membrane,where it is specifically located at sites of vesicle fusion.; Title: strong similarity to exocyst subunit Sec6 -Saccharomyces cerevisiae; plasma membrane; see citation in PMID 7615633; see citation in PMID 8978675; see citation in PMID 10203793; see citation in PMID 1523887; see citation in PMID 10873817
An04g06190	Remark: an alternative name for S. cerevisiae MRPL33 is YML33.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L30 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 2061283
An04g06200	Function: S. cerevisae DPL1 is required for the breakdown of long-chain-base phosphates like sphingosine-1-phosphate (PHS-1-P) and dihydrosphingosine-1-phosphate (DHS-1-P), which have been implicated as signaling molecules specifically stimulating a calcium-signaling mechanism.; Function: S. cerevisae dpl1delta deletion mutant,which accumulates endogenous phosphorylated sphingoid bases, exhibit unregulated proliferation upon approach to stationary phase.; Title: strong similarity to dihydrosphingosine/sphingosine phosphate lyase Dpl1 -Saccharomyces cerevisiae; see citation in PMID 9973338; see citation in PMID 10329480; see citation in PMID 11278643
An04g06210	Catalytic activity: homocitrate synthases convert 2-hydroxybutane-1,2,4-tricarboxylate + CoA to acetyl-CoA + H(2)O + 2-oxoglutarate.; Function: P. chrysogenum lys1 catalyzes the first step of the lysine and penicillin pathway.; Title: strong similarity to homocitrate synthase lys1 - Penicillium chrysogenum; see citation in PMID 9889317
An04g06240	Function: TRI10 of F. sporotrichioides controls expression of trichothecene toxin synthesis genes.; Phenotype: disruption of TRI10 in F. sporotrichioides abolished T-2 toxin production and dramatically decreased the transcript accumulation for four trichothecene genes (Tri4, Tri5, Tri6, and Tri101) and an apparent farnesyl pyrophosphate synthetase (Fpps) gene.; Remark: disruption of TRI10 additionally increased sensitivity to T-2 toxin under certain growth conditions.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to transcription regulator TRI10 -Fusarium sporotrichioides; see citation in PMID 11679358
An04g06250	Function: it has been proposed that C. carbonum TOXA encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the predicted A. niger protein occurs from a genomic region containing a peptide synthase biosynthesis.; Similarity: C. carbonum TOXA is a member of the major facilitator superfamily.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; see citation in PMID 8704997
An04g06260	Function: B. brevis TycC is composed of six modules that each incorporate one amino acid into the peptide product.; Similarity: the predicted A. niger protein shows modular repetetive similarity to B. brevis TycC, which is 3500 aa longer.; Title: strong similarity to peptide synthase TycC -Bacillus brevis; see citation in PMID 9352938
An04g06270	Title: similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides
An04g06280	Title: strong similarity to hypothetical protein BAC47520.1 - Bradyrhizobium japonicum
An04g06290	Similarity: similarity is from the predicted A. niger protein to the central region of S. pombe zas1, which is 500 aa longer.; Similarity: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to C2H2 zinc finger protein zas1p - Schizosaccharomyces pombe
An04g06300	Title: similarity to hypothetical protein CAE76440.1 - Neurospora crassa
An04g06310	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAB91735.2 - Neurospora crassa
An04g06320	Similarity: the ORF shows also strong similarity to EST 3917 of patent WO200056762-A2 from A. niger.; Title: strong similarity to hypothetical protein SPAC19A8.14 - Schizosaccharomyces pombe
An04g06330	Complex: N. crassa NMR interacts via specific protein-protein binding with two distinct regions of NIT2.; Function: N. crassa NMR is a repressor of nitrogen metabolismus, acting via inhibition of transcriptional activation by NIT2.; Title: similarity to repressor of nitrogen metabolism NMR - Neurospora crassa; see citation in PMID 9427402
An04g06340	Similarity: the ORF shows strong similarity to the A. niger protein An12g01370. The ORF, however, is much shorter than An12g01370 (154 compared to 667 amino acids).; Title: strong similarity to hypothetical protein encoded by An12g01370 - Aspergillus niger
An04g06350	Catalytic activity: dihydrokaempferol 4-reductases convert to Cis-3,4-leucopelargonidin + NADP(+) to (+)-dihydrokaempferol + NADPH.; Function: P. hybrida DFR is involved in flavonoid-biosynthetis.; Title: similarity to dihydroflavenol 4-reductase DFR - Petunia hybrida; see citation in PMID 2491667
An04g06360	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An04g06370	Function: the mouse homologe of T. nigroviridis SART1, Haf, is a DNA-binding factor involved in transcriptional activation induced by hypoxia.; Title: similarity to hypoxia-associated transcriptional activator SART1 - Tetraodon nigroviridis; see citation in PMID 10887110; see citation in PMID 11410364
An04g06380	Catalytic activity: aspartate aminotransferases convert L-aspartate + 2-oxoglutarate to oxaloacetate + L-glutamate.; Function: aspartate aminotransferases are involved in amino acid and nitrogen metabolism.; Localization: there are two aspartate aminotransferase isozymes in M. musculus, one is located in the mitochondrion and one in the cytoplasm.; Title: strong similarity to mitochondrial aspartate aminotransferase mAspAT - Mus musculus; see citation in PMID 2828632; see citation in PMID 3782150; see citation in PMID 6859879
An04g06390	Title: questionable ORF
An04g06400	Title: strong similarity to hypothetical protein CAE76455.1 - Neurospora crassa
An04g06410	Remark: the patent database entry is an amino acid sequence derived by conceptual translation from RT-PCR DNA.; Title: weak similarity to protein fragment SEQ ID NO:30180 from patent EP1033405-A2 - Zea mays
An04g06420	Title: strong similarity to hypothetical protein SPAC12G12.14 - Schizosaccharomyces pombe
An04g06430	Function: zinc finger-containing proteins are usually transcription regulators, and the domain is directly involved in DNA binding.; Remark: the C2H2 zinc finger is composed of two short beta strands followed by an alpha helix; the amino terminal part of the helix binds the major groove in DNA binding zinc fingers.; Similarity: The C2H2 zinc finger is the classical zinc finger domain, where the two conserved cysteines and histidines co-ordinate a zinc ion.; Similarity: the similarity to BMZF3 of H. sapiens is due to the presence of four zinc fingers in the predicted ORFs; similarly, the predicted ORF shows similarity to many other putative zinc finger proteins.; Title: similarity to zinc finger protein BMZF3 from patent WO9962951-A1 - Homo sapiens
An04g06450	Title: questionable ORF
An04g06490	Catalytic activity: DHHB-MT catalyzes the reaction: S-Adenosyl-L-methionine + 3-Hexaprenyl-4,5-dihydroxybenzoate = S-Adenosyl-L-homocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate.; Localization: in S. cerevisiae the COQ3 gene product, DHHB-MT, is a mitochondrial protein.; Pathway: this reaction is the fourth step in the biosynthesis of ubiquinone (coenzyme Q) from p-hydroxybenzoic acid.; Similarity: the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase (DHHB-MT) of R. norvegicus is very similar to the yeast homologue COQ3, and can complement COQ3 mutations in S. cerevisiae.; Title: strong similarity to 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase - Rattus norvegicus; See PMID 9932649; See PMID 8125303
An04g06500	Function: BRAP2 of H. sapiens binds to the nuclear localization signal of the tumor suppressor gene BRCA1.; Localization: as human BRAP2 is mainly localized in the cytoplasm, its proposed function is to be a cytoplasmic retention protein for BRCA1, thus regulating its transcriptional activity.; Similarity: as for human BRAP2, the main structural feature of the predicted ORF is to contain zinc fingers and leucine zippers in the middle and C-terminal regions of the protein, respectively.; Title: strong similarity to BRCA1-associated protein 2 BRAP2 - Homo sapiens; See PMID 9497340; See PMID 10819535
An04g06510	Function: ubiquitin is involved in the ATP-dependent selective degradation of cellular proteins, the maintenance of chromatin structure, the regulation of gene expression, the stress response, ribosome biogenesis and intracellular sorting of membrane proteins.; Similarity: an A. niger EST corresponding to part of the predicted ORF has been patented under patentnumber WO200056762-A2.; Similarity: the predicted ORF is constituted by four ubiquitin units, the only differences with the S. cerevisiae homologue UBI4 being that the yeast gene contains five ubiquitin units and that, at position 28 of the ubiquitin unit, the predicted ORF shows a conservative substitution Ser > Thr.; Title: strong similarity to polyubiquitin 5 Ubi4 -Saccharomyces cerevisiae; cytoplasm; See PMID 8657109; See PMID 8922277; See PMID 8982460; See PMID 3038523; See PMID 7721857
An04g06530	Function: zinc finger-containing proteins are usually transcription regulators, and the domain is directly involved in DNA binding.; Remark: the C2H2 zinc finger is composed of two short beta strands followed by an alpha helix; the amino terminal part of the helix binds the major groove in DNA binding zinc fingers.; Similarity: The C2H2 zinc finger is the classical zinc finger domain, where the two conserved cysteines and histidines co-ordinate a zinc ion.; Similarity: the main feature of the predicted ORF is to contain 6 C2H2 zinc finger domains, spanning all the protein lenght; this fact explains the huge number of BLASTP hits, mainly to hypothetical zinc finger proteins.; Title: similarity to hypothetical zinc-finger protein ZNF225 - Homo sapiens
An04g06550	Title: strong similarity to EST an_2064 -Aspergillus niger
An04g06570	Function: Ypd1p of S. cerevisiae is a phosphorelay intermediate between Sln1p and Ssk1p. Phenotype: disruption of YPD1 in S. cerevisisae is lethal because of the constitutive activation of the HOG1 MAPK cascade.; Remark: YDL235c ist the systematic name for YPD1 of s. cerevisisae.; Title: similarity to osmosensing phosphorelay signal transduction protein Ypd1 - Saccharomyces cerevisiae; See PMID 8808622; See PMID 10329790
An04g06580	Title: weak similarity to aczonin - Mus musculus
An04g06590	Title: weak similarity to protein from patent WO2003000906-A2 - Oryza sativa
An04g06600	Title: similarity to EST SEQ ID NO:6881 from patent WO200056762-A2 - Aspergillus oryzae
An04g06620	Function: farnesyltransferase of H. sapiens is a heterodimeric enzyme that attaches a farnesyl group to a single cysteine in several cellular proteins (EC 2. 5. 1. -).; Pathway: substrates of FTPase beta subunit include the p21ras proteins, nuclear lamins, and several retinal proteins.; Remark: FTPase beta subunit and prenyl-protein transferase DPR1/RAM1 subunit homolog are alternativ names for human farnesyl-protein transferase beta chain.; Title: strong similarity to farnesyl-protein transferase beta chain - Homo sapiens; See PMID 8494894
An04g06640	Remark: blastp matches are unspecific.; Similarity: the ORF shows also similarity to EST n5c03a1. r1 of A. nidulans.; Similarity: the ORF shows weak similarity to the A. niger protein An08g02420. The similarity is only restricted to a stretch of about 50 amino acids.; Title: weak similarity to hypothetical protein encoded by An08g02420 - Aspergillus niger
An04g06650	Title: strong similarity to hypothetical protein SPBC19C2.15c - Schizosaccharomyces pombe
An04g06660	Title: similarity to hypothetical protein G22F9.040 - Neurospora crassa
An04g06670	Complex: the major small nuclear ribonucleoproteins (snRNPs) U1, U2, U4/U6, and U5 share a set of common proteins denoted B/B', D1, D2, D3, E, F, and G which play an important part in the biogenesis of the snRNPs.; Remark: SNRNP core protein D3 is an alternative name for small nuclear ribonucleoprotein SM D3 of H. sapiens.; Similarity: human SM D3 belongs to the SNRNP core protein family.; Title: strong similarity to small nuclear ribonucleoprotein SM D3 - Homo sapiens; nucleus; See PMID 7527560
An04g06680	Similarity: the ORF encoded protein show similarity to several hypothetical proteins of different species.; Title: similarity to hypothetical protein 15E6.20 -Neurospora crassa
An04g06690	Function: pah1 of P. anserina may be a repressor of genes involved in the microconidiation process. Moreover,pah1 is involved in hyphal branching and possibly in the development of female organs.; Phenotype: deletion of the pah1 gene in P. anserina enhances the number of male gametes (microconidia), whereas overexpression of pah1 results in a decrease in microconidia.; Title: strong similarity to homeoprotein h1 pah1 -Podospora anserina; nucleus; See PMID 11123688
An04g06700	Title: weak similarity to hypothetical protein C01G5.3 - Caenorhabditis elegans
An04g06730	Function: Ttp1 participates in the cellular event of glycoprotein glycosylation essential for growth and morphogenesis, in parallel with the pathways involving Mpk1 MAP kinase and calcineurin.; Golgi; Phenotype: mnn2 mutants are defective in the addition of the first -1,2-linked mannose as it has no branches on the backbone.; Remark: MNN2 and YBR015C are alternative names for TTP1 (type II membrane protein).; Title: similarity to mannosyltransferases Ttp1 -Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928
An04g06740	Title: questionable ORF
An04g06750	Title: similarity to hypothetical transmembrane protein - Candida albicans
An04g06790	Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1).; Remark: catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template.; Remark: in plants, retrotransposons have been described in maize, Arabidopsis and wheat, and non-viral retroposons in maize.; Remark: transcription and transposition of Tto1 were observed in rice cells.; Title: similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443
An04g06800	Title: weak similarity to hypothetical protein C34C6.1 - Caenorhabditis elegans
An04g06840	Remark: alternate names for S. cerevisiae Drs2: Fun38, Swa8 or YAL026C.; Similarity: DRS2 is a member of the cation transporting (E1-E2) P-type ATPase superfamily.; Title: similarity to ATPase Drs2 - Saccharomyces cerevisiae; See PMID 10601336; See PMID 8247005
An04g06850	Remark: similarity is due to glutamate-rich region of the protein.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens
An04g06860	Remark: cypX from A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis.; Remark: putative sequencing error in second exon.; Title: similarity to cytochrome P450 monooxigenase cypX - Aspergillus parasiticus [putative frameshift]; putative frameshift; See PMID 10855719
An04g06870	Similarity: the ORF shows similarity to the A. niger protein An01g00660. The ORF is longer than An01g00660.; Title: similarity to hypothetical protein CAD21072.1 - Neurospora crassa
An04g06880	Remark: S. spectabilis spcB was cloned as part of the spectinomycin biosynthesis cluster and encodes a putative myoinositol-dehydrogenase.; Title: similarity to hypothetical myoinositol-dehydrogenase spcB - Streptomyces spectabilis; See PMID 10650224
An04g06890	Complex: in C. familiaris the 68- (SRP68) and 72-(SRP72) kD proteins of SRP are bound to the 7S RNA of SRP as a heterodimeric complex (SRP68/72), whereby SRP68 mediates the interaction with the 7S RNA.; Function: C. familiaris SRP72 is a component of the cytoplasmic ribonucleoprotein particle that mediates the targeting of proteins to the ER.; Title: similarity to 72-kD protein of the signal recognition particle SRP72 - Canis lupus; cytoplasm; See PMID 8388879
An04g06900	Title: similarity to hypothetical protein F24K9.9 -Arabidopsis thaliana
An04g06910	Protein sequence is in conflict with the conceptual translation; Function: A. oryzae amyR gene disruptants showed a significant restricted growth on starch medium and produced little of the amylolytic enzymes including alpha-amylase and glucoamylase.; Function: A. oryzae amyR is a transcriptional activator gene involved in starch/maltose-induced efficient expression of the amylolytic genes.; Gene-ID: amyR; Induction: in A. oryzae amyR was expressed in the presence of glucose comparable to the level in the presence of maltose, while the amylolytic genes amyA and agdA were transcribed at high levels only in the presence of maltose.; Remark: information concerning A. niger amyR has not yet been published.; Remark: the genomic organisation of alpha-amylase,aglA and amyR in A. niger is identical to the organisation in A. oryzae.; nucleus; putative frameshift; See PMID 10830498
An04g06920	Catalytic activity: alpha-glucosidases hydrolyse the terminal, non-reducing 1,4-linked D-glucose residues with release of D-glucose.; Gene-ID: aglU; Remark: the assigned gene name aglA in the SWISSPROT entry P56526 is probably wrong, because no other source could be found and the alpha-galactosidase of A. niger is also named as aglA.; extracellular/secretion proteins; See PMID 9165762
An04g06930	Protein sequence is in conflict with the conceptual translation; Catalytic activity: alpha-amylases catalyse the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Similarity: the predicted A. niger protein differs in few, especially terminal, aa from both known A. awamori alpha-amylase proteins, amy A and B.; Title: strong similarity to extracellular alpha-amylase amyA/amyB - Aspergillus niger; putative frameshift; See PMID 2340591
An04g06940	Function: S. pombe SPAC1399_1 is a possible regulator of maltose fermentation and contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Gene-ID: PrtT; Remark: the A. niger transcription factor might be a regulator of the genomically adjacent gene-cluster of amylolytic enzymes.; Similarity: the predicted A. niger protein shows similarity to the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain of several transcripton factors.
An04g06950	Function: D. melanogaster hth regulates the subcellular localization of the homeotic protein cofactor Extradenticle (EXD) via its N-terminal MH-domain; Similarity: D. melanogaster hth encodes a TALE class homeodomain-containing protein of the MEIS family.; Similarity: the predicted A. niger protein shows similarity to the homeodomain of several MEIS familiy proteins, but not to the MH-domain of hth.; Title: similarity to homeobox transcription factor hth - Drosophila melanogaster; nucleus; See PMID 11156989
An04g06960	Catalytic activity: NADPH + 2 Ferricytochrome = NADP+ + 2 Ferrocytochrome.; Remark: all known plant cytochrome P450 monooxygenase reactions depend on the associated activity of an NADPH:cytochrome P450 oxidoreductase (CPR; EC 1. 6. 2. 4) that catalyzes the transfer of electrons from NADPH via FAD and FMN to the prosthetic heme group of the P450 protein. Although for animal systems detailed characteristics including structural properties of CPRs have been reported, only few of these enzymes have been purified and cloned from plant sources.; Title: strong similarity to NADPH-ferrihemoprotein reductase 1 CPR1 - Petroselinum crispum; See PMID 9405720
An04g06970	Remark: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An04g06980	Function: The M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Function: The PTH11 gene of the rice blast fungus Magnaporthe grisea encodes a novel upstream component of pathogenicity signaling.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An04g06990	Catalytic activity: the human protein removes a single mannose residue from Man9GlcNAc; the product is Man8GlcNAc isomer B.; Function: might be involved in glycoprotein quality control since there is evidence that trimming of Man9GlcNAc2 to Man8GlcNAc2 isomer B in yeast cells is important to target misfolded glycoproteins for degradation.; Remark: calcium is required for enzyme activity.; Remark: the properties and specificity of this human alpha 1,2-mannosidase are identical to the endoplasmic reticulum alpha 1,2-mannosidase from S. cerevisiae.; Similarity: sequence similarity to Class I alpha 1,2-mannosidases.; Title: strong similarity to alpha 1,2-mannosidase IC - Homo sapiens
An04g07010	Function: CaM of E. nidulans activates vertebrate CaM-dependent phosphodiesterases, CaM-dependent protein kinases II, and myosin light chain kinases.; Function: CaM of E. nidulans is essential for cell cycle progression.; Title: strong similarity to calmodulin caM -Aspergillus nidulans; See PMID 2199442
An04g07020	Complex: TLG2 of S. cerevisiae interacts with vps45.; Function: TLG2 od S. cerevisiae is a t-SNARE which is involved in early endosome biogenesis.; Function: TLG2 of S. cerevisiae is a t-SNARE that functions in transport from the endosome to the late golgi and on the endocytic pathway.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Remark: YOL018c and TLG2 of S. cerevisiae are synonymous names.; Similarity: TLG2 of S. cerevisiae belongs to the syntaxin/epimorphin family.; Title: strong similarity to syntaxin Tlg2 -Saccharomyces cerevisiae; See PMID 9763449; See PMID 10028187
An04g07030	Title: similarity to hypothetical protein SPBC337.03 - Schizosaccharomyces pombe
An04g07040	Complex: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium.; Function: Clathrin is the major protein of the polyhedral coat of coated pits & vesicles. Two different adaptor protein complexes link the clathrin lattice either to the plasma membrane or trans golgi network.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to clathrin light chain Clc1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 8955161; See PMID 9133677; See PMID 2211819; See PMID 7585943
An04g07050	Function: CDC37 of S. cerevisiae functions as a protein chaperone with similar properties as Hsp82p.; Remark: CDC37 of S. cerevisiae interacts with MAP kinases.; Remark: CDC37 of S. cerevisiae may interact with several kinase systems either as a general kinase activator or as a phosphatase inhibitor.; Title: strong similarity to cell division control protein Cdc37 - Saccharomyces cerevisiae; See PMID 9060463; See PMID 10629030
An04g07060	Remark: Mdl1 of S. cerevisiae is an intracellular peptide transporter localized in the inner membrane of yeast mitochondria.; Title: strong similarity to peptide ABC transporter protein Mdl1 - Saccharomyces cerevisiae; See PMID 11251115
An04g07070	Function: FUN26 of S. cerevisiae has broad nucleoside selectivity and most likely functions to transport nucleosides across intracellular membranes.; Title: strong similarity to intracellular membrane protein involved in nucleoside transport Fun26 -Saccharomyces cerevisiae; See PMID 10827169
An04g07080	Title: similarity to hypothetical protein SPBC2G5.01 - Schizosaccharomyces pombe
An04g07090	Title: strong similarity to hypothetical protein SPBC19C2.11c - Schizosaccharomyces pombe
An04g07100	Function: Haspin is likely to be important in regulation of haploid as well as diploid cell differentiation in a variety of tissues.; Function: Haspin of M. musculus is a serine/threonine kinase that is thought to regulate cell cycle and differentiation of haploid germ cells.; Remark: Haspin was so far found only in humans and mice.; Similarity: Haspin is a member of a new family of protein kinases.; Title: similarity to haploid germ cell-specific nuclear protein kinase (haspin) GSG2 - Mus musculus; deleted EC_number 2.7.1.37; See PMID 10358056; See PMID 11311556
An04g07110	Catalytic activity: Chitin + H(2)O = chitosan + acetate.; Function: CDA1 hydrolyses the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.; Function: CDA1 of S. cerevisiae is involved ascospore wall formation.; Remark: YLR307w is a synonymous name to CDA1.; Remark: the sequencing error is confirmed (ORF-sequence is correct) and results in a frameshift.; Title: similarity to sporulation-specific chitin deacetylase Cda1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 8940152
An04g07120	Function: FRM2 of yeast functions in the fatty acid signalling pathway and is itself regulated by fatty acids.; Remark: A better BlastpPATENT hit was not annotated as a clear function could not be identified for it.; Remark: FRM2 of yeast is N-terminally 90 aa shorter than the gene product of this ORF.; Title: similarity to protein FRM2 involved in fatty acid regulation - Saccharomyces cerevisiae; See PMID 8701605
An04g07130	Remark: SPCC4B3. 10c of S. pombe is N-terminally approx. 380 aa longer.; Title: similarity to hypothetical protein SPCC4B3.10c - Schizosaccharomyces pombe
An04g07150	Remark: YBL001c and ECM15 are synonymous names.; Title: strong similarity to protein involved in cell wall biogenesis and architecture Ecm15 - Saccharomyces cerevisiae; See PMID 9335584
An04g07160	Title: similarity to hypothetical protein MLD14.3 -Arabidopsis thaliana
An04g07170	Title: strong similarity to hypothetical protein EAA65067.1 - Aspergillus nidulans
An04g07180	Remark: Gene structure was modelled according to A. niger EST.; Remark: ORF is also identical to DNA sequence patent AAF11781.; Title: strong similarity to EST an_2144 -Aspergillus niger
An04g07190	Title: similarity to hypothetical transcription regulator protein - Schizosaccharomyces pombe
An04g07200	Catalytic activity: L-kynurenine + H(2)O <=> anthranilate + L-alanine.; Function: The kynureninase from rat is one of the enzymes involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway.; Remark: A pyridoxal-phosphate protein, also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines.; Title: strong similarity to kynureninase - Rattus norvegicus; See PMID 9180257
An04g07210	Catalytic activity: Tryptophan + O2 = N-formylkynurenine.; Function: IDO of mouse is a hemoprotein that catalyzes the degradation of tryptophan to N-formyl-kynurenine.; Title: strong similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus; See PMID 1937018
An04g07220	Catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + A 2-hydroxy acid anion.; Pathway: glyoxal pathway.; Similarity: ORF has strong similarity to many hypothetical proteins (e. g. metallo-beta-lactamase family proteins).; Similarity: belongs to the glyoxalase II family.; Title: similarity to hydroxyacylglutathione hydrolase (glyoxylase II) HAGH - Homo sapiens; See PMID 8550579
An04g07230	Catalytic activity: L-Cysteine + O2 = 3-Sulfino-L-alanine.; Function: Cysteine dioxygenase is a key enzyme of cysteine metabolism in mammals.; Title: strong similarity to cysteine dioxygenase CDO1 - Rattus norvegicus
An04g07240	Function: MAL13 regulates the coordinate transcription of structural mal1s (maltase) and agt1 (maltose permease) genes.; Localization: nuclear.; Remark: MAL13 contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain.; Remark: YGR288w, MAL1R, and MAL13 are synonymous names.; Title: similarity to maltose pathway regulatory protein Mal13 - Saccharomyces cerevisiae; See PMID 2037232; See PMID 2278509
An04g07250	Similarity: ORF is also similar to human AF-9 protein which is involved in a T(9:11)(P22:Q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (mll or hrx) gene product which contains DNA-binding motifs resulting in a rogue activator protein.; Title: strong similarity to hypothetical transcription factor - Schizosaccharomyces pombe
An04g07260	Function: eryBIV of S. erythrae is involved in erythromycin biosynthesis.; Remark: eryBIV of S. erythrae is also described in patent AAX25774.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins YLL056c from S. cerevisiae and SPBC2A9. 02 from S. pombe.; Title: similarity to dTDP-4-keto-L-6-deoxyhexose-4-reductase eryBIV -Saccharopolyspora erythraea; See PMID 9353926
An04g07270	Function: human GCIP is a cyclin D-interacting protein, which reduces the phosphorylation of retinoblastoma protein by cyclin D-dependent protein kinase and inhibits E2F1-mediated transcriptional activity.; Localization: human HA-tagged p29 in HeLa cells localized in the nucleus.; Remark: human GCIP interacting protein p29 is identical to the cDNA DKFZp564O2082. 1.; Remark: human GCIP interacting protein p29 was identified using a yeast two-hybrid screen with GCIP as bait.; Title: strong similarity to GCIP-interacting protein p29 - Homo sapiens; nucleus; See PMID 10801854; See PMID 11118353
An04g07280	Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1913.
An04g07300	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An04g07310	Similarity: similarity is from the predicted A. niger protein to the EGF-domain of D. rotundus DSPA alpha 1, which contains a signal peptide, a finger (F), an epidermal growth factor (EGF), a kringle, and a serine protease domain.; Title: weak similarity to t-plasminogen activator alpha-1 DSPA-alpha1 - Desmodus rotundus
An04g07320	Function: mutations in veA allows conidiation to occur in the absence of light.; Title: similarity to dark repressor of conidiation velvet veA - Aspergillus nidulans; See PMID 2076818
An04g07330	Function: human MRPL12 is thought to act as a translational regulator of mitochondrial mRNAs.; Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1220.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L12 - Homo sapiens; localisation:mitochondrion; See PMID 8626705; See PMID 9169145
An04g07340	Complex: in S. cerevisiae CCT1-8 form the Cct chaperonin complex.; Function: S. cerevisiae CCT8 is a subunit of the Cct chaperonin complex which binds to newly synthesized actin and tubulin and can convert these proteins into an assembly-competent state.; Localization: S. cerevisiae CCT localized to the cytoplasm and the cell cortex.; Remark: an alternativ name for the S. cerevisiae Cct chaperonin complex is TCP-1.; Similarity: S. cerevisiae CCT shows similarity to GroEl.; Title: strong similarity to hypothetical cytoskeleton specific chaperonin subunit Cct8 -Saccharomyces cerevisiae; See PMID 7865875; See PMID 7916461; See PMID 8771707
An04g07350	Remark: the 5'UTR of the predicted A. niger protein is covered by the A. niger EST an_2917.; Title: weak similarity to hypothetical helicase I helA - Pseudomonas aeruginosa; See PMID 8820243
An04g07360	Title: similarity to hypothetical protein CAD70815.1 - Neurospora crassa
An04g07370	Catalytic activity: salicylate 1-monooxygenases convert salicylate + NADH + O(2) to catechol + NAD(+) + H(2)O + CO(2).; Function: P. stutzeri nahW is involved in naphthalene and salicylate metabolism, metabolising salicylate, methylsalicylates, and chlorosalicylates.; Induction: P. stutzeri nahW is induced and expressed upon incubation with salicylate.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An04g07380	Remark: see reference PubMed 10375630 for details on phenotype of S. cerevisiae YKR087c deletion mutant.; Remark: the ORF is C-terminally truncated due to contig border.; Similarity: the ORF might encode a Zn-dependent protease, as predicted for the homologues S. pombe protein,but the predicted ORF is N-terminally extended.; Title: strong similarity to hypothetical peptidase 48 family protein SPAP14E8.04 - Schizosaccharomyces pombe [truncated ORF]; See PMID 10375630
An04g07390	Title: weak similarity to hypothetical protein KIAA1359 - Homo sapiens
An04g07400	Remark: a putative sequencing error generates a stop codon.; Remark: the involvement of the pro1(+) gene in fruiting body development was confirmed by trying to complement the mutant phenotype with in vitro mutagenized and shortened versions of the pro1 open reading frame. Southern hybridization experiments also indicated that pro1(+) homologues are present in other sexually propagating filamentous ascomycetes.; Title: strong similarity to C6 zinc finger transcription factor PRO1 - Sordaria macrospora [putative sequencing error]; putative sequencing error; See PMID 10224253
An04g07410	Remark: only the N-terminal domain is matching al the homologues. All other found homologues proeteins are approximately 300 amino acids longer.; Remark: similarity to the N-terminal of novel protein kinase, SEQ ID NO: 160 patent WO200073469-A2 - Homo sapiens.; Title: similarity to N-terminal of novel protein kinase SEQ ID NO:160 from patent WO200073469-A2 - Homo sapiens
An04g07430	Remark: the EST an_3432 from Aspergillus niger also overlapps with this sequence in the 3' region.; Similarity: the ORF shows strong similarity to the A. niger EST an_2117.; Title: similarity to hypothetical protein encoded by An07g09430 - Aspergillus niger
An04g07440	Function: SHR3 of S. cerevisiae is a chaperone initiating ER-derived transport vesicle formation and thus allowing the ER-export of multiple amino acid permeases.; Remark: SHR3 of S. cerevisiae is also called D1022 and YDL212w.; Remark: SHR3 of S. cerevisiae is an integral membrane protein component of the endoplasmic reticulum.; Remark: the ORF is N-terminally truncated due to it's location at the end of the contig.; Title: similarity to endoplasmic reticulum membrane protein Shr3 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1423607; See PMID 10564255; See PMID 11069779
An04g07450	Remark: the ORF is N-terminally truncated due to contig border.; Title: questionable ORF [truncated ORF]
An04g07460	Function: the A. nidulans palFp protein is part of the pal pH signalling pathway which includes palA, palB,the pacC transcription factor, mediating regulation of gene expression by ambient pH, and a membrane sensor palI.; Title: strong similarity to ambiental pH regulatory system protein palFp - Aspergillus nidulans; See PMID 9272857; See PMID 9791171; See PMID 10476033; See PMID 10821185
An04g07470	Title: similarity to hypothetical coiled-coil protein SPAC13A11.03 - Schizosaccharomyces pombe
An04g07480	Title: strong similarity to hypothetical protein CAD70809.1 - Neurospora crassa
An04g07490	Function: human CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH suggesting a function in transcription. .; Title: similarity to Cockayne syndrome group A gene CSA - Homo sapiens; See PMID 7664335
An04g07500	Title: strong similarity to EST an_2778 -Aspergillus niger
An04g07510	Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens
An04g07530	Remark: blastp matches are not significant.
An04g07540	Title: weak similarity to serine/threonine kinase Ste20 - Saccharomyces cerevisiae; See PMID 7608157
An04g07550	Title: questionable ORF
An04g07560	Remark: Patentmatch against protein AC W37811 Genesqprot.; Title: weak similarity to Myb1 protein from patent WO9813486-A1 - Nicotiana tabacum
An04g07590	Remark: similarity corresponds to a short domain.; Title: weak similarity to erythrocyte membrane protein EMP1 - Plasmodium falciparum; See PMID 10838226
An04g07595	Title: similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048
An04g07600	Remark: similarities correspond to a short domain.; Title: questionable ORF
An04g07620	Similarity: the ORF shows similarity only in the C-terminal region to the C-terminal region of An08g12070 of A. niger; Title: similarity to hypothetical protein encoded by An08g12070 - Aspergillus niger
An04g07640	Remark: ORF 3'truncated due to end of contig.; Title: weak similarity to exo-alpha-sialidase TCNA -Trypanosoma cruzi [truncated ORF]
An04g07650	Remark: the DNA-sequence of the predicted A. niger protein contains three stopcodons indicating possible sequencing errors or an inactive protein (pseudogene).; Similarity: S. pombe Ste11 and the predicted A. niger protein contain a high mobility group (HMG) box involved in DNA-binding.; Title: similarity to transcription factor ste11p -Schizosaccharomyces pombe [putative pseudogene]; nucleus; putative pseudogene; See PMID 1657709
An04g07670	Remark: the reading frame for the predicted A. niger protein contains 36 stopcodons, hence it likely is a pseudogene.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene
An04g07680	Function: C. albicans Flu1 is an efflux transporter involved in drug resistance.; Remark: expression of the C. albicans FLU1 gene in S. cerevisiae mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: C. albicans Flu1 is a multidrug efflux transporter gene of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353
An04g07690	Title: strong similarity to arsenic resistance protein ArsH - Yersinia enterocolitica; See PMID 9006011
An04g07700	Similarity: the ORF exhibits similarity only in the C-terminal region to the C-terminal region of An04g07800 from A. niger; Title: strong similarity to hypothetical protein encoded by An04g07800 - Aspergillus niger
An04g07710	Function: more than 400 proteins containing ankyrin-repeats are known and they carry out a wide variety of biological functions including cell-cycle regulation,cytoscelatal organisation and transcriptional regulation.; Function: the ankyrin-repeat mediates protein-protein interactions.; Similarity: similarity is from the ankyrin-repeat containing central region of the predicted A. niger protein to human ANK1, which is 1000 aa longer.; Title: similarity to erythrocyte ankyrin ANK1 - Homo sapiens; See PMID 10431175
An04g07720	Function: more than 400 proteins containing ankyrin-repeats are known and they carry out a wide variety of biological functions including cell-cycle regulation,cytoscelatal organisation and transcriptional regulation.; Function: the ankyrin-repeat mediates protein-protein interactions.; Similarity: similarity is from the ankyrin-repeat containing predicted A. niger protein to mouse Ank3, which is 1400 aa longer.; Title: similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 10431175
An04g07730	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An04g07740	Title: similarity to hypothetical protein 15E6.200 -Neurospora crassa
An04g07750	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An04g07770	Title: weak similarity to core protein - Hepatitis C virus
An04g07800	Similarity: the ORF shows strong similarity to the A. niger protein An08g11810. The similarity between the two proteins, however, is restricted to a stretch of only about 110 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11810 - Aspergillus niger
An04g07840	Similarity: the ORF shows strong similarity to the A. niger protein An03g03100. The ORF is much longer than An03g03100 (518 compared to 160 amino acids).; Title: weak similarity to metalloreductase freA -Aspergillus nidulans
An04g07890	Title: weak similarity to larvicidal toxin 42K protein - Bacillus sphaericus
An04g07900	Title: strong similarity to hypothetical protein encoded by An08g12080 - Aspergillus niger
An04g07910	Remark: more than 2000 copies of various Bombyx TRAS elements can accumulate within (TTAGG)(n) sequences as unusual but orderly tandem repeats.; Remark: the pseudogene contains several internal stop-codons, and might have a longer C-terminus.; Title: similarity to non-LTR retrotransposon TRAS3 -Bombyx mori [putative pseudogene]; putative pseudogene; See PMID 11319268
An04g07920	Title: weak similarity to hypothetical virulence factor encoded by ORF2929c - Pseudomonas aeruginosa
An04g07930	Similarity: shows also some similarity to tropomyosin exons.; Title: weak similarity to hypothetical protein 29 -Bacillus phage phi105
An04g07960	Similarity: the ORF shows similarity to the hypothetical A. niger protein An18g00170. The similarity between the two proteins is restricted to a stretch of about 100 amino acids.; Title: similarity to hypothetical protein encoded by An18g00170 - Aspergillus niger
An04g07970	Function: Mx proteins have antiviral activities.; Induction: Mx proteins are induced by interferon n response to double-stranded RNA.; Similarity: Mx proteins belong to a GTPase family that includes rat dynamin, Drosophila Shibire and the yeast proteins Vps1/Spo15 and Mgm1.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and M. musculus Mx, which is 200 aa shorter.; Title: similarity to antiviral GTPase Mx - Mus musculus; See PMID 7507812
An04g07980	Remark: blastp shows significant similarity (46% positives) between the predicted A. niger protein and A. thaliana X74360 but due to shortness of both peptides the calculated probability is low (p=0,35).; Title: weak similarity to cDNA clone X74360 from patent FR2768746-A1 - Arabidopsis thaliana
An04g07990	Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and threonine rich proteins.; Similarity: the ORF shows strong similarity to the hypothetical A. niger protein An08g11870. The similarity between the two proteins extends only over a stretch of about 230 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11870 - Aspergillus niger
An04g08000	Title: weak similarity to hypothetical protein encoded by An19g00010 - Aspergillus niger
An04g08020	Similarity: C. tropicalis ARD belongs to the short-chain dehydrogenases family.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis
An04g08030	Repression: high concentrations of glucose lead to the redistribution of S. cerevisiae HEX2 to the vacuole.; Repression: low-glucose-induced expression of S. cerevisiae HEX2 is mediated by two independent repression mechanisms, in the absence of glucose, transcription is prevented by Rgt1p, a C6 zinc cluster protein; at high levels of glucose, expression is repressed by Mig1p.; Title: strong similarity to hexose transporter Hxt2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8816466; See PMID 10191260
An04g08040	Similarity: simialrity is from the Zn(2)-Cys(6) DNA-binding domain containing N-terminal region of the predicted A. niger protein to the Zn(2)-Cys(6) DNA-binding domain of several putative and validated transcription factors.; Title: similarity to transcription factor Mpp1p -Pichia angusta; See PMID 12902346
An04g08050	Title: strong similarity to hypothetical protein encoded by An02g13120 - Aspergillus niger
An04g08060	Remark: blastp with the predicted A. niger protein only retrieves random hits to proline and threonine rich proteins.
An04g08070	Function: N. crassa qa-1S is a negative regulator for the initial events in quinate/shikimate metabolism as a carbon source.; Function: in N. crassa the qa activator and repressor proteins and the inducer quinic acid interact to control expression at the transcriptional level of all the qa genes.; Function: indirect evidence suggests that the N. crassa qa-1S repressor is not a DNA-binding protein but forms an inactive complex with the activator in the absence of the inducer.; Remark: the adjacent genomic region contains a predicted A. niger proteins with similarity to another regulatory gene of the quinate/shikimate metabolism gene cluster from N. crassa.; Similarity: the predicted A. niger protein contains a Shikimate kinase and a Shikimate / quinate 5-dehydrogenase domain and is 150 aa shorter than N. crassa qa-1S.; Similarity: the qa-1S repressor protein of N. crassa is strongly homologous to the pentafunctional arom enzyme found in many lower eukaryotes.; Title: similarity to negative regulator qa-1S -Neurospora crassa; See PMID 1825499; See PMID 2525625; See PMID 2960822
An04g08080	Function: N. crassa qa-1F is a positive regulator for the five structural proteins mediating the initial events in quinate/shikimate metabolism as a carbon source.; Remark: the adjacent genomic region contains a predicted A. niger proteins with similarity to another regulatory gene of the quinate/shikimate metabolism gene cluster from N. crassa.; Similarity: the predicted A. niger protein contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding domain and is 150 aa shorter than N. crassa qa-1F.; Title: similarity to positive regulator qa-1F -Neurospora crassa; nucleus; See PMID 1825499; See PMID 2525625
An04g08090	Remark: the qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580
An04g08100	Catalytic activity: quinate + NAD+ = 5-dehydroquinate + NADH.; Pathway: first step of the quinic acid catabolic pathway; phenylalanine, tyrosine and tryptophan biosynthesis.; Remark: the QUTB sequence shows significant homology with the shikimate dehydrogenase function of the complex AROM locus of Aspergillus nidulans, and with the QA-3 quinate dehydrogenase and QA-1S (repressor) genes of Neurospora crassa.; Title: strong similarity to quinate 5-dehydrogenase qutB - Aspergillus nidulans; See PMID 2976880
An04g08110	Title: strong similarity to hypothetical pathogenicity protein PEP2 - Nectria haematococca; See PMID 11208022
An04g08120	Remark: strong similarity to Corynebacterium glutamicum sequence 439 patent WO0100843-A/439.; Similarity: belongs to the shikimate 5-dehydrogenases.; Title: strong similarity to sequence 439 from patent WO0100843-A - Corynebacterium glutamicum
An04g08140	Remark: the similarity is only in a small asparagin rich domain.; Title: weak similarity to Ras guanine nucleotide exchange factor RasGEFB - Dictyostelium discoideum
An04g08150	Title: strong similarity to EST an_2637 -Aspergillus niger
An04g08160	Title: weak similarity to hypothetical protein F37C4.5 - Caenorhabditis elegans
An04g08180	Title: weak similarity to disintegrin-like metalloproteinase splice form 1 ADAM11 - Homo sapiens
An04g08190	Catalytic activity: ATP + H2O = ADP + orthophosphate.; Pathway: oxidative phosphorylation; photosynthesis.; Remark: a group of membrane-bound multi-subunit complexes in mitochondria, chloroplasts and bacteria in which ATP hydrolysis is coupled with transport of protons. In sealed vesicles the ATPase acticity is latent, unless a proton ionophore is available to discharge the proton gradient; these enzymes do not form a stable phosphoenzyme intermediate. Water-soluble subunit complexes (F1-CF1) can be extracted from these membrane-bound enzymes, which retain the ATPase activity but not the proton-transporting activity.; Remark: nearly identical to EST an_2903 from A. niger.; Similarity: belongs to the H+-transporting ATP synthase lipid-binding proteins. Remark:; Title: strong similarity to mitochondrial ATP synthase subunit 9 oliC31 - Aspergillus nidulans; See PMID 2880279
An04g08210	Catalytic activity: ATP + Pyruvate + H2O = AMP + Phosphoenolpyruvate + Orthophosphate.; Pathway: pyruvate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: the ppsA gene in E. coli codes for PEP synthase, which converts pyruvate into phosphoenolpyruvate (PEP), an essential step in gluconeogenesis when pyruvate or lactate are used as a carbon source.; Remark: this ORF is putative a pseudogene cause of more than 6 Frameshifts in the coding region.; Similarity: to other phosphoenolpyruvate synthases.; Title: strong similarity to pyruvate water dikinase ppsA - Escherichia coli [putative sequencing error]; putative sequencing error; See PMID 1310524
An04g08220	Catalytic activity: (S)-lactate + NAD+ = pyruvate + NADH.; Pathway: glycolysis / gluconeogenesis; cysteine metabolism; pyruvate metabolism; propanoate metabolism.; Remark: ldhA codes for a 36-kDa protein that converts pyruvate to lactate. Production of LdhA was greatest when glucose was the carbon source, followed by xylose and trehalose; all of these sugars could be fermented to lactic acid.; Similarity: belongs to the family of malate/lactate dehydrogenases.; Title: strong similarity to lactate dehydrogenase ldhA - Rhizopus arrhizus; See PMID 10831409
An04g08230	Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: shows also strong similarity to Arabidopsis thaliana DNA fragment SEQ ID NO: 35384 patent EP1033405-A2.; Remark: the Arabidopsis gene, AFC1, induces three STE12-dependent processes even in signal transduction-defective yeast strains: mating-specific gene expression in haploid yeast, mating of haploid yeast to yield diploids, and pseudohyphal growth in diploid yeast.; Similarity: belongs to the serine/threonine protein kinases.; Title: strong similarity to protein kinase AFC1 -Arabidopsis thaliana; deleted EC_number 2.7.1.37; See PMID 7991592
An04g08240	Title: weak similarity to hypothetical protein CAF32051.1 - Neurospora crassa
An04g08250	Remark: strong similarity to Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum
An04g08260	Remark: weak similarity to Arabidopsis thaliana protein fragment SEQ ID NO:30705 patent EP1033405-A2; Title: weak similarity to protein fragment SEQ ID NO:30705 from patent EP1033405-A2 - Arabidopsis thaliana
An04g08290	Title: similarity to hypothetical protein EAA74627.1 - Gibberella zeae
An04g08300	Remark: Among the four polyamine transporters in S. cerevisiae, those encoded by TPO2 and TPO3 were specific for spermine, whereas those encoded by TPO1 and TPO4 recognized spermidine and spermine.; Remark: alternative name is YGR138c; Similarity: belongs to the benomyl/methotrexate resistance protein family.; Title: strong similarity to membrane protein Tpo2 -Saccharomyces cerevisiae; vacuole; See PMID 11171066
An04g08320	Similarity: the ORF shows also similarity to a variety of monocarboxylate transporters.; Similarity: the ORF shows strong similarity to the A. niger EST SEQ ID NO:4112.; Title: strong similarity to protease Mch5 -Saccharomyces cerevisiae; See PMID 8755496
An04g08330	Catalytic activity: orotidine 5'-phosphate + pyrophosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: pyrimidine metabolism.; Remark: N-terminal truncated ORF due to end of contig.; Remark: URA5 genes encode orotidine-5'-monophosphate pyrophosphorylase (OMPpase), an enzyme involved in pyrimidine biosynthesis.; Similarity: belongs to the orotate phosphoribosyltransferases.; Title: strong similarity to orotidine-5-monophosphate pyrophosphorylase - Ajellomyces capsulatus [truncated ORF]; See PMID 9748447
An04g08340	Remark: also strong similarity to Aspergillus flavus multidrug resistance protein Afl-MDR1 patent WO9626952-A1.; Remark: expression of AFUMDR1 in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus flavus; plasma membrane; See PMID 9373135
An04g08350	Title: weak similarity to glutamic acid release inhibitory peptide from patent JP07149795-A - Agelenopsis aperta
An04g08360	Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An04g08370	Catalytic activity: UDPgalactose + 2-(2-Hydroxyacyl)sphingosine = UDP + 1-(beta-D-Galactosyl)-2-(2-hydroxyacyl)sphingosine.; Remark: galactosylceramide (galactocerebroside,GalC) and its sulfated derivative, sulfatide, are major lipid components of the central and peripheral nervous system myelin sheath. The human enzyme UDP-galactose:ceramide galactosyltransferase (CGT, EC 2. 4. 1. 45) catalyzes the final step of galactosylceramide synthesis.; Similarity: belongs to the Glycosyl transferases,related to UDP-glucuronosyltransferases.; Title: similarity to ceramide UDPgalactosyltransferase CGT - Homo sapiens; See PMID 9125199
An04g08380	Remark: strong similarity to Mortierella ramanni diacylglycerol acyl transferase MR1 patent WO200001713-A2.; Remark: the Mortierella ramanni MR1 enzyme is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates. The DNA sequences encoding DAGAT can be used to modify the triacylglycerol and lipid composition of plant cells.; Title: strong similarity to diacylglycerol acyl transferase MR1 from patent WO200001713-A2 - Mortierella ramanniana
An04g08390	Remark: introduction of extra copies of orf10 and orf11 genes in an S. coelicolor actIII mutant restores the ability to produce actinorhodin. Transcriptional analysis and DNA footprinting indicate that Orf10 represses its own transcription and regulates orf11 transcription.; Similarity: belongs to short-chain alcohol dehydrogenase with different specificities.; Title: strong similarity to oxidoreductase of short-chain ORF11 - Streptomyces coelicolor; See PMID 10400594
An04g08400	Title: weak similarity to hypothetical possible CHE-2 homologue L4738.06 - Leishmania major
An04g08410	Catalytic activity: benzoate + NADPH + O2 = 4-hydroxybenzoate + NADP+ + H2O.; Pathway: phenylalanine metabolism.; Remark: Cytochrome P450 enzyme systems are found throughout nature and are involved in many different, often complex, bioconversions. In the endoplasmic reticulum of the filamentous fungus Aspergillus niger a cytochrome P450 enzyme system is present that is capable of the para-hydroxylation of benzoate. The expression of the two genes encoding the components of this system, the cytochrome P450 gene encoding benzoate para-hydroxylase (bphA) and the gene encoding cytochrome P450 reductase (cprA), are inducible by benzoate.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 10852481; See PMID 2250647
An04g08420	Title: strong similarity to hypothetical protein CAD21260.1 - Neurospora crassa
An04g08440	Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An04g08450	Title: questionable ORF
An04g08460	Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe
An04g08470	Title: weak similarity to hypothetical protein Vng6427h - Halobacterium sp.
An04g08480	Remark: YKT6 is an essential gene that codes for a novel vesicle-associated SNARE functioning at the endoplasmic reticulum-Golgi transport step in the yeast secretory pathway. Depletion of Ykt6p results in the accumulation of the p1 precursor (endoplasmic reticulum form) of the vacuolar enzyme carboxypeptidase Y and morphological abnormalities consistent with a defect in secretion. Bet1p, p28, and p14) suggests that multimeric interactions are features of the fusion machinery, and may also improve the fidelity of vesicle targeting.; Remark: alternative names is YKT6.; Title: strong similarity to cell division control protein SLY2 homolog YKL196c - Saccharomyces cerevisiae; See PMID 7923363; See PMID 9211930
An04g08490	Title: similarity to essential gene protein #54 from patent WO200286090-A2 - Aspergillus fumigatus
An04g08500	Remark: rodA encodes a small, moderately hydrophobic polypeptide containing 8 cysteines arranged in a pattern similar to that observed in three hydrophobic cell wall proteins from the Holobasidiomycete Schizophyllum commune. The Aspergillus and Schizophyllum 8-cysteine polypeptides define a class of secreted, hydrophobic, fungal cell wall proteins that are important in the formation and function of aerial structures such as conidiophores and mushrooms.; Title: strong similarity to rodletless protein rodA - Aspergillus nidulans; See PMID 2065971
An04g08510	Remark: CYP3A9 cDNA was expressed in E. coli and the expressed P450 3A9 is active in the demethylation of erythromycin as well as benzphetamine.; Title: similarity to cytochrome P450 3A9 CYP3A -Rattus norvegicus; See PMID 8660328
An04g08520	Title: weak similarity to hypothetical protein EAA78112.1 - Gibberella zeae
An04g08530	Remark: the ORF is short in length (73 amino acids).
An04g08550	Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism.; Remark: expression of the T. reesei cDNA in yeast showed that it encoded a protein with endoglucanase activity; Title: strong similarity to endoglucanase IV EGIV -Trichoderma reesei
An04g08560	Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Pathway: pyruvate metabolism.; Remark: analysis of KlCYB2 gene expression indicated that, in contrast to S. cerevisiae, the major regulatory feature is induction by lactate.; Similarity: belongs to the L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases.; Title: strong similarity to cytochrome b2 cyb2 -Kluyveromyces lactis; See PMID 10806428
An04g08580	Remark: its functions of binding ATP and of autophosphorylation and eIF-2 alpha phosphorylation are inhibited by hemin.; Title: strong similarity to translation initiation factor eIF-2 alpha chain kinase HRI - Oryctolagus cuniculus; See PMID 1671169; See PMID 1679235
An04g08590	Catalytic activity: cyclobutadipyrimidine (in DNA) = 2 pyrimidine (in DNA).; Remark: photolyases and blue light receptors belong to a superfamily of flavoproteins that make use of blue and UVA light either to catalyze DNA repair or to control development.; Similarity: belongs to the deoxyribodipyrimidine photo-lyases.; Title: strong similarity to DNA photolyase phr1 -Trichoderma harzianum; See PMID 10318850
An04g08600	Remark: the transcriptional activator XlnR regulates the transcription of the xlnB, xlnC, and xlnD genes encoding the main xylanolytic enzymes (endoxylanases B and C and beta-xylosidase, respectively). Also, the transcription of the genes encoding the accessory enzymes involved in xylan degradation, including alpha-glucuronidase A, acetylxylan esterase A, arabinoxylan arabinofuranohydrolase A, and feruloyl esterase A, was found to be controlled by XlnR. In addition, XlnR also activates transcription of two endoglucanase-encoding genes, eglA and eglB, indicating that transcriptional regulation by XlnR goes beyond the genes encoding xylanolytic enzymes and includes regulation of two endoglucanase-encoding genes.; Similarity: belongs to the GAL4 zinc binuclear cluster proteins.; Title: strong similarity to transcription activator xlnR - Aspergillus niger; See PMID 9758775; See PMID 10760176; See PMID 9466262
An04g08620	Remark: Hap1 S. cerevisiae binds to two classes of DNA elements, UAS1/CYC1 and UAS/CYC7, and permits differential transcriptional activation at these sites. In yeast, oxygen sensing and heme signaling are primarily mediated by the heme activator protein Hap1, which, in response to heme, activates the transcription of genes required for respiration and for controlling oxidative damage.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to heme activator protein Hap1 -Saccharomyces cerevisiae; See PMID 10617612; See PMID 11212295; See PMID 2643482
An04g08630	Function: a ketone is treated with a transaminase in the presence of a primary amine as amino donor to produce the amines.; Function: the chiral amines are synthetic intermediates for use as pharmaceuticals and agrochemicals.; Function: the present sequence represents a protein with stereoselective transaminase activity.; Function: the transaminase is used to produce the optically active amines (having R-chirality) of the invention.; Remark: protein sequence of patentprot.; Title: strong similarity to protein with stereoselective transaminase activity from patent WO9848030-A1 - Arthrobacter sp.
An04g08640	Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae
An04g08650	Function: aapA is a transmembrane protein and probably a aminoacid or metabolite transport protein.; Similarity: shows only partial similarity to aapA of B. subtilis.; Title: strong similarity to hypothetical protein encoded by An18g03630 - Aspergillus niger
An04g08660	Similarity: blast hits result from repetitive sequences.; Title: weak similarity to hypothetical protein BAT2 - Homo sapiens
An04g08670	Title: strong similarity to hypothetical protein EAA61363.1- Aspergillus nidulans
An04g08680	Function: CCA1 carries out addition of CCA to 3'-end of tRNA without a template.; Title: strong similarity to tRNA nucleotidyltransferase Cca1 - Saccharomyces cerevisiae
An04g08690	Function: patented novel nucleic acids and peptides derived from open reading frame X, useful for treating e. g. cancers, proliferative disorders, neurodegenerative disorders and cardiovascular disease.; Similarity: shows similarity to hypothetical proteins of S. pombe, A. thaliana etc.; Title: similarity to polynucleotide sequence SEQ ID NO:3913 from patent WO200058473-A2 - Homo sapiens
An04g08700	Title: similarity to hypothetical protein SPBC1604.18c - Schizosaccharomyces pombe
An04g08710	Function: retransformation of uvsH77 mutants of A. nidulans with the rescued cosmids from the MMS-resistant transformants resulted in restoration of both UV and MMS resistance to wild-type levels.; Title: strong similarity to protein involved in DNA repair and recombination uvsH - Aspergillus nidulans; nucleus
An04g08720	Title: similarity to hypothetical protein CAE85531.1 - Neurospora crassa
An04g08730	Similarity: show strong similarity to conserved hypothetical proteins of several species.; Title: strong similarity to hypothetical conserved protein SPAC12B10.16c - Schizosaccharomyces pombe
An04g08740	Function: Pas10p plays an important role in protein translocation across the peroxisome membrane.; Localization: Pas10p is an integral protein of the peroxisome membrane.; Title: strong similarity to peroxisome assembly protein PAS10 - Pichia pastoris; peroxisome; See PMID 8670828
An04g08750	Similarity: shows only partial similarity at the aminoterminus.; Title: strong similarity to hypothetical protein EAA61357.1 - Aspergillus nidulans
An04g08760	Complex: NMD3 of S. cerevisiae associates with ribosomes.; Function: NMD3 is a component of the nonsense-mediated mRNA decay pathway.; Remark: NMD3 of S. cerevisiae is also known as SRC5 and has a systematic name of YHR170W.; Title: strong similarity to nonsense-mediated mRNA decay protein Nmd3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9933353; See PMID 10022925; See PMID 10590466
An04g08790	Remark: patent describes novel nucleic acids and peptides derived from open reading frame X, useful for treating e. g. cancers, proliferative disorders,neurodegenerative disorders and cardiovascular disease.; Similarity: shows partial similarity to conserved hypothetical proteins of S. cerevisiae, S. pombe, etc and a human protein that might be a transcriptional regulator.; Title: similarity to ORFX ORF1691 polynucleotide sequence SEQ ID NO:3381 from patent WO200058473-A2 - Homo sapiens
An04g08800	Function: Leu5p involved in the accumulation of CoA in mitochondria, presumably by serving as a transporter of CoA or a precursor thereof.; Localization: Leu5p of S. cerevisiae is inserted into the mitochondrial inner membrane along the specialized import pathway used by carrier proteins.; Phenotype: as a consequence, the activities of several mitochondrial CoA-dependent enzymes were strongly decreased in Deltaleu5 cells.; Phenotype: deletion of LEU5 (strain Deltaleu5) was accompanied by a 15-fold reduction of mitochondrial coenzyme A (CoA) levels but did not affect the cytosolic CoA content.; Title: strong similarity to mitochondrial carrier Leu5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11158296
An04g08810	Function: protein of S. cerevisiae is a component of a complex involved in chromatin remodelling.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to subunit of Isw2 chromatin remodelling complex Itc1 - Saccharomyces cerevisiae; nucleus; See PMID 8840506
An04g08820	Function: enzyme of S. cerevisiae is involved in adding glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein.; Pathway: enzyme of S. cerevisiae is involved in glycosylation.; Similarity: shows similarity to Alg6p, S. pombe and C. elegans hypothetical proteins.; Title: strong similarity to glucosyltransferase Alg8 - Saccharomyces cerevisiae; endoplasmatic reticulum
An04g08830	Function: coatomer from ret1-1 cells but not from ret2-1 cells binds to the cytosolic tail of Emp47p.; Function: protein of S. cerevisiae may recycle to ER because it is found in ER is a sec12 mutant.; Function: retrieval of Emp47p from Golgi blocked in ufe1-1, sec20-1, and sec21-1 mutants.; Localization: protein of S. cerevisiae is a Golgi membrane protein.; Similarity: only shows similarity to the aminoterminal part of the S. cerevisiae protein.; Title: similarity to Golgi membrane protein Emp47 -Saccharomyces cerevisiae
An04g08840	Phenotype: mutations in the APECED apeced gene are thought to be involved in the autosomal rezessive autoimmune polyglandular syndrome type I.; Remark: the H. sapiens AIRE (autoimmune regulator) is thought to be a transcription factor.; Similarity: the predicted A. niger protein encodes two zinc-finger-like motifs (aa 464-505, 587-645, PF00628) found in nuclear proteins which are involved in chromatin-mediated transcriptional regulation.; Title: similarity to hypothetical autoimmune regulator AIRE-2 - Homo sapiens; See PMID 9398839
An04g08860	Function: the S. pombe 442K curved DNA-binding protein is a non essential protein that preferentially binds curved DNA and binds non-curved DNA with a much lower affinity.; Remark: the S. pombe 442K curved DNA-binding protein was isolated by means of a DNA-binding gel shift assay with synthetic curved DNA.; Similarity: the S. pombe 442K curved DNA-binding protein belongs to the peptidase family M24C, also known as the map family 2.; Title: strong similarity to 442K curved DNA-binding protein SPAC23H4.09 - Schizosaccharomyces pombe; nucleus; See PMID 7985416
An04g08880	Remark: Blastp matches are due to repetetive sequences.; Title: similarity to hypothetical protein CAD60573.1 - Podospora anserina
An04g08890	Catalytic activity: the predicted P. eryngii protein converts aromatic primary alcohol and O(2) to an aromatic aldehyde and H(2)O(2).; Remark: the pedicted A. niger protein shows strong similarity to the conserved PFAM domain PF00732, which encodes a glucose-methanol-choline (GMC) oxidoreductase sequence common for a lot of proteins like choline dehydrogenase (CHD), methanol oxidase (MOX) and cellobiose dehydrogenase.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; See PMID 1425667
An04g08900	Title: strong similarity to hypothetical protein 68B2.50 - Neurospora crassa
An04g08920	Function: the S. cerevisiae SNF5 gene affects expression of both glucose- and phosphate-regulated genes.; Remark: alternative names of the S. cerevisiae SNF5 protein are HAF4, SWI10, TYE4 and the systematic name is YBR289W.; Similarity: the predicted A. niger protein shows similarity to a broad range of transcriptin factors conserved regions.; Title: strong similarity to transcription activator Snf5 - Saccharomyces cerevisiae; nucleus; See PMID 2233708
An04g08940	Phenotype: mutation in the bimD gene of Aspergillus nidulans results in a mitotic block in anaphase characterized by a defective mitosis.; Remark: the ORF is truncated due to the border of the contig.; Title: strong similarity to hypothetical mitosis regulatory protein bimD - Aspergillus nidulans [truncated ORF]; See PMID 8375649
An04g08950	Title: questionable ORF
An04g08970	Protein sequence is in conflict with the conceptual translation; Function: the function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression.; Similarity: although the function of the predicted protein remains elusive, the expression of this gene is confirmed by the partial identity to A. niger EST EMBLEST:BE759453.; Similarity: besides the similarity to S. pombe SPCC126. 07c, that covers less or more the total length of the predicted protein, the other BLASTP hits are due to a very short, but very conserved, PHD-finger domain.; Similarity: the PHD finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation; the PHD finger motif is reminiscent of, but distinct from the C3HC4 type RING finger.; Similarity: the predicted protein indeed contains also a RING-type zinc finger.; Title: strong similarity to hypothetical PHD-type zinc finger protein SPCC126.07c - Schizosaccharomyces pombe [putative sequencing error]; putative sequencing error; See PMID 7701562
An04g08980	Phenotype: S. cerevisiae haploid and diploid null mutants of RPL43A form only microcolonies.; Remark: S. cerevisiae L43A is also called L37A, YL35, RPL43A, YPR043W, YP9499. 02, or YJR094BW.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L43a - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 9559554
An04g08990	Title: strong similarity to hypothetical protein sll1601 - Synechocystis sp.
An04g09000	Catalytic activity: epoxide hydrolases catalyze the hydrolysis of an epoxide to a glycol.; Localization: the rat cytosolic epoxide hydrolase is located mainly in the cytoplasm, but also in the peroxisome; this unusual bicompartmental distribution is due to the targeting sequence Ser-Lys-Ile, located at the extreme C-terminus of the rat protein, slightly different from the peroxisomal targeting sequence (PTS) Ser-Lys-Leu found in other peroxisomal enzymes.; Similarity: the C-terminus of the predicted protein is Ser-Arg-Leu; considering that in rat a conservative substitution Leu > Ile causes a difference in the protein targeting, the location of the A. niger putative protein cannot be exactely predicted.; Similarity: the N-terminal half of the predicted protein shows only weak similarity to rat epoxide hydrolase.; Title: strong similarity to epoxide hydrolase -Rattus norvegicus; See PMID 1743286; See PMID 2654139; See PMID 3277731; See PMID 8349641
An04g09010	Phenotype: null mutation of YPR094w of S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein YPR094w - Saccharomyces cerevisiae
An04g09020	Function: TWF1 of S. cerevisiae acts as an actin monomer sequestering protein in vitro and is involved in regulation of the cortical actin cytoskeleton; no kinase activity was detected for purified yeast twinfilin.; Phenotype: in S. cerevisiae diploid homozygous deletion mutants of TWF1 show random budding pattern and bumpy surface morphology, while TWF1 overexpression causes depolarization of the cortical actin cytoskeleton.; Remark: TWF1 of S. cerevisiae is also called YGR080w.; Similarity: the predicted ORF shows stronger similarity to Human and mouse A6 kinase, a protein whit kinase activity in vitro, but with unknown physiological function; A6 kinases are of special interest because they lack any of the motifs commonly conserved in the catalytic domains of protein kinases.; Title: similarity to twinfilin A Twf1 -Saccharomyces cerevisiae; See PMID 9020587; See PMID 9249064; See PMID 9700161; See PMID 7507208
An04g09030	Function: SFC1 of S. cerevisiae is a mitochondrial succinate-fumarate transporter, involved in the regulation of acetyl-CoA synthetase activity.; Induction: SFC1 of S. cerevisiae is induced by ethanol or acetate as sole carbon sources, whereas is repressed by glucose.; Remark: SFC1 of S. cerevisiae is also called ACR1 or YJR095w.; Title: strong similarity to mitochondrial succinate-fumarate transporter Sfc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9395087; See PMID 9559855; See PMID 9894915; See PMID 7908717
An04g09050	Similarity: the ORF shows similarity to some probable transmembrane proteins.; Title: strong similarity to hypothetical sterol transporter YMR034c - Saccharomyces cerevisiae
An04g09062	Function: the X. laevis PARN enzyme is a poly(A)-specific 3' exonuclease that does not require an A residue at the 3' end. The addition of 25 nonadenylate residues at the 3' terminus, or a 3' terminal phosphate is inhibitory.; Title: strong similarity to poly(A)-specific ribonuclease PARN - Xenopus laevis
An04g09065	Remark: synonyms for YmL17 from S. cerevisiae are YNL252c, YmL30, rotein N0864.; Title: similarity to ribosomal protein of the large subunit Yml17 - Saccharomyces cerevisiae; See PMID 9151978
An04g09070	Function: ramA of C. stercorarium hydrolysis terminal non-reducing alpha-L-rhamnoase residues in alpha-L-rhamnosides.; Title: strong similarity to alpha-L-rhamnosidase ramA - Clostridium stercorarium; See PMID 10632887
An04g09080	Function: IgA protease of H. influenzae cleaves host immunoglobulinA (an antibody produced by mucosae for defense against pathogens) and thus alleviates host infection.; Remark: the ORF is N-terminally truncated due to it's location at the end of the contig.; Title: similarity to IgA protease IgA1 - Haemophilus influenzae [truncated ORF]; See PMID 11163480
An04g09090	Title: strong similarity to hypothetical protein AAM08685.1 - Aspergillus fumigatus
An04g09100	Title: strong similarity to hypothetical protein YLR002c - Saccharomyces cerevisiae
An04g09120	Similarity: the ORF shows weak similarity to YLR128W of S. cerevisiae which is believed to be involved in cell polarity.; Title: similarity to hypothetical protein SPBC839.03c - Schizosaccharomyces pombe
An04g09130	Remark: in our prediction no transmembrane domains were found, whereas the similar protein pmp22 is an integral membrane protein of the peroxisome membrane.; Title: similarity to peroxisomal membrane protein PMP22 - Arabidopsis thaliana; peroxisome; See PMID 10318708
An04g09140	Function: the ORF sequence shows weak similarity to human dynactin-1 (DCTN1), which is involved in retrograde movement of vesicles and organelles along microtubules.; Remark: no tRNA ligase was found in the BLASTp output, although a Prosite tRNA ligase pattern was predicted.; Title: similarity to hypothetical protein AAM08684.1 - Aspergillus fumigatus
An04g09150	Title: strong similarity to hypothetical protein AAM08678.1 - Aspergillus fumigatus
An04g09160	Remark: unusual intron/exon structure for A. niger.
An04g09170	Complex: Cdc48p interacts with Ufd3p, an WD containing protein involved in a proteasome dependend proteolytic pathway distinct from the N-end rule pathway.; Function: S. cerevisiae Cdc48p is an essential ATPase required for the cell cycle progression and the homotypic fusion of endoplasmic reticulum membranes.; Localization: S. cerevisiae Cdc48p is mainly attached to the endoplasmic reticulum, but relocalizes in a cell cycle-dependent manner and enters the nucleus during late G1.; Remark: valosin-containing protein VCP, a highly conserved human homolog of Cdc48p, is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.; Similarity: the A. niger EST an_3570 in EMBLEST:BE759220 overlaps with the ORF.; Title: strong similarity to valosin-containing protein like AAA-ATPase Cdc48 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 1860879
An04g09220	Complex: S. cerevisiae Ste11p and Ste50p associate through their respective N-terminal domains.; Function: the S. cerevisiae homolog Ste50p is involved in the regulation and direction of Ste11p activity. Ste11p, which is a MAPKKK, is involved in several signaling cascades, like the pheromone response pathway or the high osmolarity glycerol (HOG) pathway.; Title: strong similarity to protein involved in pheromone signal transduction pathway Ste50 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error
An04g09230	Function: the S. cerevisiae homolog Nha1p is an alkalication antiporter mediating Na+ and K+ efflux through the plasma membrane that. Nha1p is required for alkali cation tolerance at acidic pH and enables growth on high concentrations of KCl and NaCl at acidic pH.; Title: strong similarity to Na+/H+-exchanging protein Nha1 - Saccharomyces cerevisiae; plasma membrane
An04g09250	Function: the S. cerevisiae homolog Mvp1p is required for sorting proteins to the yeast vacuole and inteacts genetically with VPS1.; Similarity: S. cerevisiae Mvp1p shows homology to the family of sorting nexins (SNX).; Title: strong similarity to protein involved in vacuolar protein sorting Mvp1 - Saccharomyces cerevisiae
An04g09260	Similarity: belongs to the superfamily of AAA-type ATPases (ATPases associated with various cellular activities).; Title: strong similarity to hypothetical protein SPBC947.11c - Schizosaccharomyces pombe
An04g09270	Title: weak similarity to SAP90 associated protein SAPAP1 from patent JP10201477-A - Homo sapiens
An04g09290	Function: the Emericella nidulans homolog amdX is involved in the regulation of the acetamidase-encoding amdS gene.; Title: strong similarity to DNA binding regulatory protein amdX - Aspergillus nidulans
An04g09350	Title: strong similarity to EST SEQ ID NO:4226 from patent WO200056762-A2 - Aspergillus niger
An04g09360	Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID NO:5624 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical protein CC0812 - Caulobacter crescentus
An04g09380	Function: the A. nidulans homolog prnB encodes the major proline transport system.; Similarity: A. nidulans prnB is highly similar to the arginine and histidine transporters of S. cerevisiae.; Title: strong similarity to proline permease prnB -Aspergillus nidulans
An04g09390	Catalytic activity: Streptomyces sp. dauC transfers a methyl group from S-adenosylmethionine to aklanonic acid.; Pathway: daunomycin biosynthesis.; Remark: the Streptomyces sp. homolog dauC is a homodimer with an M(r) of ca. 48,000.; Title: similarity to hypothetical aklanonic acid methyltransferase dauC - Streptomyces sp.
An04g09400	Title: strong similarity to hypothetical protein encoded by An01g12020 - Aspergillus niger
An04g09410	Catalytic activity: D-arabinitol + NAD(+) <=> D-xylulose + NADH.; Function: the Bacillus spec. homolog AAY56815 encodes a D-arabinitol dehydrogenase.; Title: strong similarity to D-arabinitol dehydrogenase AAY56815 from patent JP11332569-A - Bacillus sp.
An04g09420	Function: the Neurospora crassa homolog mtr is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa
An04g09440	Remark: the A. niger ORF is C-terminally truncated due to the contig border.
An04g09450	Remark: blastp matches are unspecific.
An04g09480	Catalytic activity: idhA of S. loti catalyzes the reaction myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.; Remark: the A. niger ORF shows similarity to different dehydrogenases.; Title: similarity to myo-inositol dehydrogenase idhA - Sinorhizobium meliloti; See PMID 9802033
An04g09500	Similarity: the a. niger protein also shows similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 52144 from patent EP1033405-A2.; Title: strong similarity to hypothetical aldehyde reductase 6 alr6 - Colletotrichum gloeosporioides
An04g09510	Title: similarity to hypothetical UbiE/COQ5 family methlytransferase - Caulobacter crescentus
An04g09520	Function: in Aspergillus sp. the biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes including omtB.; Function: omtB of Aspergillus sp. catalyses the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361
An04g09530	Similarity: Nodulisporium sp. pks contains a ketoacyl synthase and an acyl transferase domain.; Title: strong similarity to melanin polyketide synthase PKS - Nodulisporium sp.; See PMID 10628853
An04g09540	Function: rabbit CYP4A4 hydroxylates fatty acids in the omega-position.; Localization: rabbit CYP4A4 was isolated from microsomes.; Title: similarity to fatty acid omega-hydroxylase cytochrome P-450 CYP4A4 - Oryctolagus cuniculus; See PMID 8239664
An04g09550	Complex: P. fluorescens hapE forms a homodimer of approximately 140 kDa with each subunit containing a noncovalently bound FAD molecule.; Function: P. fluorescens hapE catalyses Baeyer-Villiger oxidation of aromatic compounds.; Function: P. fluorescens hapE catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate and a wide range of other acetophenones are accepted as substrate.; Title: strong similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873
An04g09560	Remark: information regarding M. anisopliae 4MeS has not yet been published and is available from http://www. fgsc. net/asilomar/pathfact. html.; Title: similarity to hypothetical protein 4MeS -Metarhizium anisopliae
An04g09570	Function: S. cerevisiae TPO1 is a H(+)-gradient dependent vacuolar import polyamine transporter specific for spermidine and spermine.; Remark: the systematic name for S. cerevisiae TPO1 is YLL028W.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11171066
An04g09580	Function: E. faecalis kanamycin kinas confers kanamycin resistance.; Similarity: E. faecalis kanamycin kinase is a 3'5''-aminoglycoside phosphotransferase of type III.; Title: weak similarity to kanamycin kinase -Enterococcus faecalis; See PMID 6313476
An04g09610	Function: S. cerevisiae SNG1 acts neiter via depletion of glutathione pools nor DNA repair and its expression is not contolled by MNNG metabolism genes regulator YAP1.; Function: overexpression of S. cerevisiae SNG1 confers hyper-resistance to the mutagen N-methyl-N'nitro-N-nitrosoguanidine (MNNG) while sng1 null mutants exhibit only slight sensitivity to MNNG.; Title: similarity to nitrosoguanidine resistance factor Sng1 - Saccharomyces cerevisiae; See PMID 7753113
An04g09620	Function: S. cerevisiae Agp2p functions as a carnitine-H+ symporter.; Function: carnitine is the carrier for the transport of acetyl-CoA from peroxisomes to mitochondria during beta-oxidation of fatty acids.; Localization: by immunoelectron microscopy S. cerevisiae HA-tagged Agp2 localizes to plasma membrane, ER membranes and vacuoles.; Localization: by western blots of S. cerevisiae HA-tagged Agp2 from fractionated cells and colocalisation with marker enzymes for various subcellular compartments it was shown that Agp2 localizes in the plasma membrane and the ER.; Remark: carnitine is a quatery amine ((R)-3-carboxy-2-hydroxy-N,N,N-tri-methyl-1-propanaminium hydroxide) which has been suggested as a supplement during ketogenic diet.; Remark: the systematic name for S. cerevisiae AGP2 is YBR132c.; Similarity: S. cerevisiae Agp2 belongs to the aa-permease superfamily.; Title: strong similarity to carnitine transporter Agp2 - Saccharomyces cerevisiae; See PMID 10545096
An04g09630	Title: similarity to nucleic acid-binding protein NuABP-39 from patent WO200044900-A2 - Homo sapiens
An04g09640	Title: strong similarity to hypothetical protein encoded by An15g02090 - Aspergillus niger
An04g09650	Function: B. circulans aman6 is a yeast mannan backbone degrading enzyme.; Title: similarity to alpha-1,6-mannanase aman6 -Bacillus circulans; See PMID 11055417
An04g09660	Similarity: similarity with other proteins is due to glutamic acid rich regions.; Title: similarity to hypothetical serine/threonine protein kinase AAO52136.1 - Dictyostelium discoideum
An04g09670	Function: Rhodococcus sp. SoxC catalyses the first step of a pathway to remove covalently bound sulfur from dibenzothiophene (dbt) without breaking carbon-carbon bonds.; Function: Rhodococcus sp. SoxC sulfur dioxygenase oxidizes DBT to DBT-5,5'-dioxide.; Remark: an alternative name for Rhodococcus sp. SoxC is dszC.; Similarity: Rhodococcus sp. SoxC is similar to members of the acyl coenzyme A dehydrogenase family.; Title: strong similarity to sulfur dioxygenase SoxC - Rhodococcus sp.; See PMID 7574582; See PMID 7961424
An04g09680	Function: mutations in Y. lipolytica GPR1 confer high sensitivity to low concentrations of acetic acid and ethanol, even in presence of glucose.; Function: mutations in Y. lipolytica GPR1 inhibit expression of acetyl-coenzyme A synthetase (ACS), which produces Acetyl-coenzyme A from acetate and therby induces the expression of the glyoxylate cycle enzymes on acetate as carbon source.; Title: similarity to glyxoxylate pathway regulator GPR1 - Yarrowia lipolytica; See PMID 10572261; See PMID 1349449
An04g09690	Catalytic activity: pectin methylesterases convert pectin + N H(2)O to N methanol + pectate.; Function: A. aculeatus PME1 acts in synergy with polygalacturonases in the degradation of plant cell wall pectin.; Function: A. aculeatus PME1 is involved in maceration and soft-rotting of plant tissue.; Title: strong similarity to pectin methylesterase pme1 - Aspergillus aculeatus; See PMID 8920970
An04g09700	Function: A. tubingensis xghA is involved in carbohydrate utilisation and specifically degrades a xylose-substituted galacturonic acid backbone.; Title: strong similarity to endo-xylogalacturonan hydrolase xghA - Aspergillus tubingensis; See PMID 10618200
An04g09710	Catalytic activity: Acetylcholinesterases convert an acetic ester + H(2)O to ester + acetate.; Function: R. norvegicus AChE deacetylates a variety of acetic esters.; Similarity: the predicted A. niger protein shows similarity to several carboxylesterases and lipases.; Title: similarity to acetylcholinesterase AChE -Rattus norvegicus; See PMID 8417155; See PMID 11283752
An04g09720	Title: strong similarity to pathogenicity gene PEP2 - Nectria haematococca; See PMID 11208022
An04g09730	Function: P. vivianii luciferase is an oxidoreductase with characteristics of a ligase, and synthesizes a variety of (di)nucleoside polyphosphates with four or more inner phosphates.; Title: strong similarity to luciferase PvGR -Phrixothrix vivianii; See PMID 10387072; See PMID 11007993
An04g09740	Function: S. cerevisiae QDR1 is a multidrug resistance determinant against ketoconazole and quinidine,but not the stereoisomer quinine.; Localization: in S. cerevisiae fluorescence microscopy observation indicated that Qdr1p is a plasma membrane protein.; Remark: the predicted A. niger protein shows similarity to several S. cerevisiae members of the major facilitator superfamily with different substrate specifities (e. g. BZR1 - low-chain organic acids, DTR1 -dityrosine transporter).; Remark: the systematic name for S. cerevisiae QDR1 is YIL120w.; Similarity: S. cerevisiae QDR1 is a member of the major facilitator superfamily.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822
An04g09750	Catalytic activity: folylpolyglutamate synthetases convert ATP + {tetrahydrofolyl-[Glu]}(N) + L-glutamate to ADP + phosphate + {tetrahydrofolyl-[Glu]}(N+1).; Function: S. cerevisiae Met7 is involved in one-carbon metabolism, which is essential to provide activated one-carbon units in the biosynthesis of methionine, purines, and thymidylate.; Function: S. cerevisiae strains without functional met7 are methionine, adenine and thymidine auxotroph and maintenance of mitochondrial DNA is disturbed.; Localization: S. cerevisiae Met7 appears to encode both the cytoplasmic and mitochondrial forms of the enzyme.; Remark: alternative names for S. cerevisiae Met7 are Met23 and YOR241w.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10775416; See PMID 10799479
An04g09760	Complex: in N. crassa a direct protein-protein interaction between nit-2 and nit-4 is essential for optimal expression of the nit-3 structural gene.; Function: N. crassa nit-4 is a regulatory gene in the nitrogen circuit and is required for the expression of nit-3 and nit-6.; Remark: ORF 5'truncated due to end of contig.; Similarity: N. crassa nit-4 contains a single Gal4-type Zn(II)2Cys6 binuclear-type zinc finger DNA-binding domain.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa [truncated ORF]; nucleus; See PMID 9632783; See PMID 1840634
An04g09770	Remark: Archaeoglobus fulgidus esterase VC16-16MC encodes a heat stable esterase which is active in organic solvents, useful in cheese or paper manufacture, and to study plant resistance to disease; Remark: Archaeoglobus fulgidus esterase VC16-16MC patent WO9730160-A1.; Title: strong similarity to esterase VC16-16MC from patent WO9730160-A1 - Archaeoglobus fulgidus
An04g09790	Title: strong similarity to hypothetical protein encoded by An04g07190 - Aspergillus niger
An04g09810	Remark: strong similarity to sugarbeet choline monooxygenase CMO patent WO9830702-A2.; Remark: used to, e. g. transform plants to provide increased resistance to stressful conditions, increase pest resistance or increase feed value.; Title: strong similarity to choline monooxygenase CMO from patent WO9830702-A2 - Beta vulgaris
An04g09820	Remark: Fructosyl amino acid oxidase (FAOD), is an active toward model compounds of the glycated proteins in blood, N epsilon-fructosyl N sigma-Z-lysine and N-fructosyl valine.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 9022674; See PMID 9139700; See PMID 9013588
An04g09830	Function: pat genes encode a phosphinothricin acetyltransferase (PAT) and is widely applied in plant genetic engineering.; Similarity: the similarity of the ORF to pat of S. coelicolor is restricted to the second half of the proteins.; Title: similarity to phosphinothricin acetyltransferase pat - Streptomyces coelicolor; See PMID 9631092
An04g09840	Title: similarity to hypothetical protein encoded by An16g06250 - Aspergillus niger
An04g09850	Remark: Git1p in yeast contains a sugar transport motif and 12 potential membrane-spanning domains. Transport assays performed on a git1 mutant together with the above evidence indicate that the GIT1 gene encodes a permease involved in the uptake of glycerophosphoinositol.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 9691030
An04g09870	Catalytic activity: cholesterol + NADPH + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O.; Pathway: bile acid biosynthesis.; Remark: the microsomal oxysterol 7alpha-hydroxylase enzyme, active in the acidic pathway for bile acid synthesis.; Similarity: belongs to the human cytochrome P450 family.; Title: strong similarity to oxysterol 7alpha-hydroxylase CYP7b1 - Homo sapiens; See PMID 9802883
An04g09890	Remark: cell wall protects fungi against lysis and determines their cell shape. Alpha-glucan is a major carbohydrate component of the fungal cell wall; ags1(+),which encodes a putative alpha-glucan synthase consists of two probable catalytic domains for alpha-glucan assembly,namely an intracellular domain for alpha-glucan synthesis and an extracellular domain speculated to cross-link or remodel alpha-glucan.; Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe; See PMID 9689051
An04g09900	Title: strong similarity to hypothetical protein encoded by An07g06270 - Aspergillus niger
An04g09910	Remark: LovC Aspergillus terreus interacts with lovastatin nonaketide synthase (LNKS) and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An04g09920	Remark: similarity to human PRO1072 protein sequence patent WO9946281-A2.; Remark: the ORF seems to be a putative ketoreductase with unknown specificity.; Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to human PRO1072 protein sequence from patent WO9946281-A2 - Homo sapiens
An04g09940	Remark: CIH1 Colletotrichum lindemuthianum is a fungal proline-rich glycoprotein which appears to form a cross-linked structure in planta and, as such, resembles plant cell wall proline- and hydroxyproline-rich proteins.; Title: similarity to intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; See PMID 9721685
An04g09960	Catalytic activity: cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.; Remark: can be used for modification of host cells for the production of heterologous proteins or for producing proteins for use in cleaning compositions.; Remark: similarity to Bacillus subtilis serine protease SP1 (YUXL) patent WO9903984-A2.; Similarity: to dipeptidyl aminopeptidases/acylaminoacyl-peptidases and to colicin tolerance protein tolB from several bacteria. .; Title: similarity to serine protease SP1 YUXL from patent WO9903984-A2 - Bacillus subtilis
An04g09980	Title: similarity to putative nitrilase CAE27004.1 -Rhodopseudomonas palustris
An04g09990	Function: degradation of 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-ddol) into 2,5-dichlorohydroquinone (2,5-dchq).; Pathway: degradation of gamma-hexachlorocyclohexane.; Remark: also strong similarity to EST an_3163 Aspergillus niger.; Remark: the linC gene Sphingomonas paucimobilis is essential for the assimilation of gamma-HCH in UT26.; Similarity: belongs to the short-chain dehydrogenases/reductases family (sdr).; Title: strong similarity to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linC - Sphingomonas paucimobilis; See PMID 7515041
An04g10000	Similarity: strong similarity to patent WO0100804-A/247 from Corynebacterium glutamicum found in TREMBL:AX066343_1.; Similarity: the ORF shows similarity to several MFS efflux transporters.; Title: strong similarity to multidrug transporter from patent WO0100804-A - Corynebacterium glutamicum
An04g10010	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity to the M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An04g10020	Remark: only the N-terminal domain of the ORF is matching to the central part of the dihydrofolate reductase.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538
An04g10030	Remark: the multifunctional polyketide synthase (PKS)-encoding gene (PKS1) Cochliobolus heterostrophus has six catalytic domains arranged in the following order,starting at the N terminus: beta-ketoacyl synthase,acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: the polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 10913297; See PMID 8953776
An04g10040	Catalytic activity: the Bacillus subtilis myo-inositol 2-dehydrogenase converts Myo-inositol and NAD(+) to 2,4,6/3,5-pentahydroxycyclohexanone and NADH.; Induction: the Bacillus subtilis myo-inositol 2-dehydrogenase is induced by myo-inositol and is strongly repressed by rapidly metabolizable carbohydrates such as D-glucose, D-mannose, D-fructose and glycerol .; Title: strong similarity to myo-inositol 2-dehydrogenase yisS - Bacillus subtilis; See PMID 6322857
An04g10050	Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe
An04g10060	Remark: the flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes.; Remark: the predicted A. niger protein contains a PF00743 flavin-binding monooxygenase-like domain.; Remark: the predicted A. niger protein shows similarity to a broad range of predicted proteins only C-terminal of aa 190.; Title: similarity to flavin monooxygenase fccC from patent WO200004158-A2 - Bacterium 2412.1
An04g10070	Catalytic activity: the uronat dehydrogenase generally converts D-Galacturonate and NAD and H2O to D-Galactarate and NADH.; Remark: the DE19604798-A1 variant can be used for synthesis of L-ascorbic acid.; Title: strong similarity to uronate dehydrogenase variant R57E from patent DE19604798-A1 - Saccharomyces cerevisiae
An04g10080	Remark: the L. lactis alcohol-acetaldehyde dehydrogenase belongs to the not further caracterised familiy of multifunctional alcohol dehydrogenases.; Title: strong similarity to hypothetical alcohol-acetaldehyde dehydrogenase adhE - Lactococcus lactis; See PMID 9620952
An04g10090	Pathway: the K. lactis protein RAG5 is involved in the regulation of HGT1.; Remark: the K. lactis HGT1 shows 26 to 31% amino acid identity to the Hxtp family of glucose transport elements in S. cerevisiae.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679
An04g10100	Title: similarity to polyketide synthase PKS17 -Botryotinia fuckeliana; See PMID 14676319
An04g10110	Title: similarity to hypothetical protein encoded by An11g00040 - Aspergillus niger
An04g10120	Title: weak similarity to hypothetical protein encoded by An16g05030 - Aspergillus niger
An04g10130	Catalytic activity: the 3-isopropylmalate dehydrogenase converts 3-carboxy-2-hydroxy-4-methylpentanoate and NAD(+) to 3-carboxy-4-methyl-2-oxopentanoate and NADH.; Gene-ID: leu2B; Pathway: the 3-isopropylmalate dehydrogenase is part of theValine, leucine and isoleucine biosynthesis .; Remark: an alternate name of the 3-isopropylmalate dehydrogenase is beta-isopropylmalate dehydrogenase.; See PMID 8781173
An04g10150	Title: similarity to hypothetical protein encoded by An02g12900 - Aspergillus niger
An04g10180	Catalytic activity: C. symbiosum hgdB catalyses the elimination of water from (R)-2-hydroxyglutaryl-CoA to glutaconyl-CoA.; Remark: C. symbiosum hgdB is part of the radicalic catalytic pathway, present in many Clostridium species,which enables those to ferment aminoacids.; Title: similarity to hypothetical 2-hydroxyglutaryl-CoA dehydratase hgdB - Clostridium symbiosum; See PMID 10491198
An04g10230	Title: similarity to hypothetical protein AAN66273.1 - Pseudomonas putida
An04g10250	Title: weak similarity to hypothetical protein encoded by An08g08870 - Aspergillus niger
An04g10270	Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to hypothetical protein FLJ10830 - Homo sapiens [putative frameshift]; putative frameshift
An04g10280	Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Title: weak similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740
An04g10290	Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: Acts on a wide range of carbonyl compounds,including quinones, aromatic aldehydes, ketoaldehydes,daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. B-specific with respect to NADPH.; Title: similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208
An04g10300	Title: strong similarity to hypothetical longevity-assurance protein 1 - Schizosaccharomyces pombe
An04g10320	Function: quinone reductases are electron-transfer proteins.; Induction: the activity of QR in cultures of P. chrysosporium increased following the addition of 2-dimethoxybenzoquinone, vanillic acid, or several other aromatic compounds.; Similarity: the ORF shows strong similarity to minor allergens of the fungi A. alternata and C. herbarum and to trp repressor binding protein of E. coli.; Title: strong similarity to 1,4-benzoquinone reductase QR - Phanerochaete chrysosporium; See PMID 7898496; See PMID 8516330; See PMID 9925562
An04g10340	Catalytic activity: UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Title: similarity to sterol glucosyltransferase ugt52 - Dictyostelium discoideum; See PMID 10224056
An04g10350	Function: efflux of the antibiotic cycloheximide by H+ antiport (TC 2. A. 1. 2. 2).; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa [putative frameshift]; putative frameshift; See PMID 1628836
An04g10360	Title: similarity to BCU0021 protein SEQ ID 8 from patent WO2003029421-A2 - Homo sapiens
An04g10400	Title: strong similarity to hypothetical brown 2 protein abr2 - Aspergillus fumigatus
An05g00010	Title: weak similarity to cell differentiation protein LagC - Dictyostelium discoideum
An05g00020	Remark: UME6 of S. cerevisiae is also called CAR80,NIM2, RIM16 or YDR207C.; Similarity: the similarity to UME6 of S. cerevisiae and other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: weak similarity to transcription factor Ume6 - Saccharomyces cerevisiae; nucleus
An05g00040	Title: weak similarity to leukocyte common antigen precursor CD45 - Rattus norvegicus
An05g00050	Function: Prolidase of S. domuncula hydrolyzes the peptide bond that involves the imino nitrogen of proline or hydroxyproline; hence, it catalyzes the final step in collagen degradation.; Title: strong similarity to prolidase - Suberites domuncula; See PMID 10373628
An05g00070	Catalytic activity: leukotriene-A4 hydrolases catalyze the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoa te (leukotriene A4) + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tet raenoate (leukotriene B4).; Pathway: mouse leukotriene-A4 hydrolase is involved in leukotriene B4 biosynthesis which is a pro-inflammatory mediator in myeloid cells.; Similarity: the A. niger protein also shows strong similarity to Caenorhabditis elegans aminopeptidase.; Similarity: the A. niger protein also shows strong similarity to human leukotriene-A4 hydrolase a bifunctional cytosolic enzyme, which both hydrolyses leukotriene A4 (LTA4) into leukotriene B4 (LTB4) and exerts aminopeptidase activity against opioid peptides.; Title: strong similarity to leukotriene-A4 hydrolase - Mus musculus; See PMID 1710117
An05g00080	Function: CBP3 of S. cerevisiae is required for the assembly of the respiratory chain complex coenzyme QH2-cytochrome c reductase.; Remark: the N-terminal 30% are not conserved between the A. niger protein and CBP3 of S. cerevisiae.; Title: similarity to membrane protein Cbp3 -Saccharomyces cerevisiae; See PMID 2544586
An05g00090	Title: strong similarity to hypothetical protein YPR040w - Saccharomyces cerevisiae
An05g00100	Localization: immunofluorescence studies using a specific antibody have shown that Aik is localized to the spindle pole during mitosis, especially from prophase through anaphase.; Similarity: human AIK shows strong similarity to Aurora of Drosophila and related S. cerevisiae Ipl1 kinase. These are required for normal chromosome segregation.; Title: strong similarity to aurora/IPL1-related kinase AIK - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9153231
An05g00110	Similarity: the A. niger protein also shows similarity to human KUB3, a protein with unknown function that binds the DNA binding subunit of DNA-dependent protein kinase.; Title: strong similarity to hypothetical protein YNR020c - Saccharomyces cerevisiae
An05g00120	Pathway: PRO1 catalyzes the first step in proline biosynthesis.; Similarity: PRO1 shows strong similarity to other to other glutamate 5-kinases.; Title: strong similarity to glutamate 5-kinase Pro1 - Saccharomyces cerevisiae; See PMID 1350780
An05g00130	Function: yeast KRE9 gene encodes a 30-kDa secretory pathway protein involved in the synthesis of cell wall (1-->6)-beta-glucan.; Phenotype: disruption of KRE9 leads to serious growth impairment and an altered cell wall containing less than 20% of the wild-type amount of (1-->6)-beta-glucan.; Similarity: yeast KRE9 belongs to the KRE9 / KNH1 family.; Title: similarity to cell wall synthesis protein KRE9 - Candida albicans; extracellular/secretion proteins; See PMID 8413233
An05g00140	Complex: the yeast signal recognition particle receptor is composed of the alpha and the beta chain.; Function: the signal recognition particle and its receptor target nascent secretory proteins to the ER.; Remark: YKL154w is the systematic name for SRP102,the gene encoding SRbeta.; Similarity: SRalpha and SRbeta are both members of the GTPase superfamily.; Title: similarity to signal recognition particle receptor beta chain Srp102 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9679135
An05g00160	Function: yeast cystathionine beta-synthase converts serine and homocysteine to cystathionine.; Pathway: yeast CYS4 is involved in the sulfide incorporation and transsulfuration pathway.; Similarity: yeast CYS4 belongs to the cysteine synthase/cystathionine beta- synthase family.; Title: strong similarity to cystathionine beta-synthase Cys4 - Saccharomyces cerevisiae; See PMID 8017103; See PMID 8366024
An05g00170	Function: the Hum1 protein of S. cerevisiae has been postulated to be involved in cellular adaption to elevated extracellular Ca2+ concentrations and to be a means to attenuate the propagation of Ca2+ signals in this organism.; Function: the Hum1 protein of S. cerevisiae is required for vacuolar Ca2+/H+ exchange.; Function: vacuolar membrane vesicles from hum1 S. cerevisiae mutants lack all Ca2+/H+ antiport activity,demonstrating that the Hum1 protein catalyzes the exchange of Ca2+ for H+ across the yeast vacuolar membrane.; Remark: Hum1 of S. cerevisiae is also called mnr1,vcx1, and YDL128w.; Title: strong similarity to vacuolar Ca(2+)/H+-exchanging protein Hum1 - Saccharomyces cerevisiae; vacuole; See PMID 8668190; See PMID 10219995; See PMID 10371152
An05g00180	Title: similarity to hypothetical protein B13M15.020 - Neurospora crassa
An05g00190	Function: yeast PCL7 is a cylin like protein that interacts with the Cdk PHO85. This PHO85/PCL7 complex phosphorylates Pho4p in vitro.; Remark: YIL050w is the systematic name for PCL7.; Remark: the similarity of the A. niger protein to PCL7 is restricted to the C-terminus and contains the cyclin box.; Remark: yeast PCL7 expression is constant during cell cycle.; Title: similarity to cyclin like protein Pcl7 -Saccharomyces cerevisiae; See PMID 9032248; See PMID 9520600
An05g00200	Function: yeast AKR1 affects the kinase cascade downstream of Gbetagamma.; Function: yeast AKR1 has a negative effect on signaling in the pheromone pathway.; Function: yeast AKR1 may be involved in coupling the activities of a Bem1p-Cdc24p-Cdc42p complex to an upstream signaling system, the pheromone-responsive G protein.; Remark: YDR264C is the systematic name for AKR1.; Title: strong similarity to ankyrin repeat-containing protein Akr1 - Saccharomyces cerevisiae; See PMID 8524293; See PMID 8649369; See PMID 9243510
An05g00220	Catalytic activity: psbA is involved in the conversion of L-Orn to its N(5)-OH derivative.; Function: D-N(5)-hydroxyornithine (D-N(5)-OH-Orn) is the hydroxamate ligand of the fluorescent siderophore Pseudobactin(B10).; Function: fluorescent siderophores play a role in biocontrol of deleterious rhizomicroorganisms.; Pathway: psbA is involved in D-N(5)-hydroxyornithine (D-N(5)-OH-Orn) synthesis.; Phenotype: The L-Orn N(5)-hydroxylase-defective mutants of Pseudomonas strain B10 were much less effective than the parental strains in suppressing the growth of the phytopathogen Erwinia carotovora in iron-poor medium.; Title: strong similarity to L-ornithine N5-hydroxylase psbA - Pseudomonas sp.; See PMID 11029447
An05g00280	Function: SWE1 is a protein kinase that acts both on serines and on tyrosines.; Function: SWE1 is able to phosphorylate Cdc28p on tyrosine and inhibit its activity.; Remark: the similarity of the A. niger protein to SWE1 of S. cerevisiae is restricted to the C-terminal half of the A. niger protein which is about 200 amino acids longer than SWE1.; Title: similarity to protein kinase Swe1 -Saccharomyces cerevisiae; See PMID 8253069
An05g00290	Phenotype: the cdc28-P8 mutant accumulates unspliced precursors at the restrictive temperature. Consistent with this phenotype is the similarity to the Prp2, Prp16, and Prp22 proteins from budding yeast, which are required for the splicing of mRNA precursors.; Phenotype: the fission-yeast gene cdc28+ was originally identified in a screen for temperature-sensitive mutants that exhibit a cell-division cycle arrest and was found to be required for mitosis.; Title: strong similarity to ATP-dependent RNA helicase cdc28p - Schizosaccharomyces pombe; nucleus; See PMID 8862522
An05g00300	Function: cytochrome b5 is a membrane bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases.; Localization: microsomal membrane. bound to the cytoplasmic side of the endoplasmic reticulum.; Remark: the A. niger also shows similarity to mitochondrial L-lactate dehydrogenase (cytochrome) of s. cerevisiae, which is about 5 times longer than the A. niger protein.; Title: similarity to microsomal cytochrome b5 cytb5 - Musca domestica; endoplasmatic reticulum; See PMID 8900138
An05g00310	Title: strong similarity to hypothetical nuclear migration protein - Neurospora crassa
An05g00340	Catalytic activity: cis-epoxysuccinate hydrolase catalyses the reaction cis-epoxysuccinate + H(2)O = L(+) tartaric acid.; Remark: epoxides are used as chiral building blocks in the organic synthesis of fine chemicals, especially enantiomerically pure compounds.; Remark: tartaric acid is used in the food industry as an additive in soft drinks, a food preservative and a raw material for the synthesis of emulsifiers.; Remark: the use of cis-epoxysuccinate hydrolase in the production of tartaric acid precludes contamination of L(+) tartaric acid with the D(+) form, which is considered harmful to humans.; Similarity: the predicted A. niger protein shows strong similarity to the cis-epoxysuccinate hydrolase (LMGP-18079) of patent EP911392-A1 (AC# AAY04477) from R. rhodochrous. the best blastP match is the conserved hypothetical protein B11N2. 300 from N. crassa.; Title: strong similarity to cis-epoxysuccinate hydrolase (LMGP-18079) from patent EP911392-A1 -Rhodococcus rhodochrous
An05g00350	Remark: a putative frameshift results in a premature STOP codon.; Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of fragment SEQ ID NO: 4378 of patent EP1033405-A2 (AC# AAG07282) and hypothetical proteins from diverse procaryotic and eucaryotic species.; Title: strong similarity to protein fragment SEQ ID NO:4378 from patent EP1033405-A2 - Arabidopsis thaliana [putative frameshift]; putative frameshift
An05g00370	Function: the signal transduction pathway mediated by the N. crassa ras2 protein regulates the apical growth of hyphae, cell wall synthesis, and conidial formation in N. crassa.; Phenotype: smco7 mutant exhibits very slow hyphal growth and the rate of conidial formation was approximately one two-hundredth of wild type.; Remark: the N. crassa ras2 disruptant shows morphological characteristics very similar to those of the smco7 mutant, which also maps to linkage group V. the smco7 mutant harbored a single base deletion in the NC-ras2 gene, which is predicted to result in the truncation of the protein product. smco7 mutation causes both the changes in the pattern of hyphal growth and the defects in cell wall synthesis.; Similarity: the predicted A. niger protein shows strong similarity to the ras-2 protein of N. crassa, which belongs to the ras subfamily of small GTP-binding proteins.; Title: strong similarity to protein ras-2 -Neurospora crassa; See PMID 9180696
An05g00390	Catalytic activity: acetyl coenzyme A synthetase of T. pyriformis catalyses the reaction ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA.; Pathway: acetyl coenzyme A synthetase of T. pyriformis is involved in glycolysis / gluconeogenesis,pyruvate / propanoate metabolism and in the reductive carboxylate cycle (CO2 fixation).; Regulation: expression of the acetyl-CoA synthetase gene in Tetrahymena cells was dramatically decreased at 30 min after end of heat treatment (EHT) prior to entering synchronous cell division (which occurs 75 min after EHT).; Remark: acetyl coenzyme A synthetase of T. pyriformis also acts on propanoate and propenoate.; Similarity: the predicted A. niger protein shows strong similarity to the acetyl coenzyme A synthetase of T. pyriformis and other acetyl coenzyme A synthetases from procaryotic and eucaryotic species.; Title: strong similarity to acetyl coenzyme A synthase - Tetrahymena pyriformis; See PMID 10510317
An05g00400	Remark: N-terminally truncated ORF due to end of contig.; Similarity: similarity of the predicted A. niger protein to DNA-directed RNA polymerase and various other protein sequences is due to low complexity sequences, which consist of serine, alanine and proline.; Title: weak similarity to amphiphysin IIc1 - Homo sapiens [truncated ORF]; See PMID 9603201
An05g00410	Catalytic activity: 5,10-methylenetetrahydrofolate + glycine + H(2)O <=> tetrahydrofolate + L-serine.; Cofactor: pyridoxal phosphate.; Function: the serine hydroxymethyltransferase, a pyridoxal phosphate-dependent enzyme, catalyses the interconversion of serine and glycine.; Pathway: the serine hydroxymethyltransferase is involved in the Glycine, serine and threonine metabolism and in the Lysine degradation.; Remark: in eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.; Title: strong similarity to serine hydroxymethyl-transferase I Shm1 - Candida albicans; See PMID 10641038
An05g00420	Title: similarity to human ORFX ORF1903 polypeptide sequence SEQ ID NO:3806 from patent WO200058473-A2 - Homo sapiens
An05g00430	Title: similarity to hypothetical competence-damage inducible protein CinA - Streptococcus pyogenes
An05g00440	Remark: the extracted coding region has N-terminal no homologies.; Title: strong similarity to human transmembrane protein from patent WO200056891-A2 - Homo sapiens; plasma membrane
An05g00450	Function: Rev1 of H. sapiens is involved in translesion repair together with the DNA polymerase zeta.; Remark: normally, the replication fork stops at (e. g. UV-induced) DNA mismatches. Translesion repair, however,is a mechanism to overcome this replication blockage.; Remark: the ORF is much shorter than Rev1 of H. sapiens (327 compared to 1250 amino acids) and the similarity between the two proteins is restricted to a stretch of about 100 amino acids. However, the ORF shows weak similarity to Rev1 of several species.; Title: weak similarity to translesion repair protein Rev1 - Homo sapiens; See PMID 11485998
An05g00460	Remark: the ORF is extremely short in length (34 amino acids).; Title: questionable ORF
An05g00470	Remark: the ORF has an unusual exon/intron structure.
An05g00480	Function: stuA of A. nidulans is a transcription factor, regulating the orderly differentiation and spatial organization of the conidiophore cell types.; Induction: transription of stuA mRNA increases in A. nidulans approximately 50-fold during the establishment of developmental competence.; Title: strong similarity to transcription factor involved in differentiation stuA - Aspergillus nidulans; nucleus; See PMID 1516832; See PMID 9312029
An05g00490	Function: itr2 of S. pombe is a transporter for myo-inositol.; Phenotype: S. pombe mutants of itr2 are defective in inositol transport.; Remark: itr2 of S. pombe belongs to the sugar transporter family.; Remark: itr2 of S. pombe is also called SPAC20G8. 03.; Repression: itr2 of S. pombe is repressed by glucose.; Similarity: the ORF is longer than itr2 of S. pombe (951 compared to 557 amino acids).; Title: strong similarity to myo-inositol transporter 2 itr2p - Schizosaccharomyces pombe; See PMID 9560432
An05g00500	Catalytic activity: P450rm of R. minuta catalyzes the formation of isobutene from isovalerate.; Pathway: P450rm of R. minuta is involved in the 4-hydroxylation of benzoate.; Remark: P450rm of R. minuta belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 8882724
An05g00510	Function: NADP-cytochrome reductases catalyse the reduction of heme-thiolate-dependent monooxygenases.; Induction: cprA of A. niger is induced by benzoic acid, which is the substrate of bphA.; Pathway: cprA of A. niger is (together with bphA) part of the para-hydroxylation of benzoate.; Title: strong similarity to NADPH cytochrome P450 oxidoreductase cprA - Aspergillus niger; See PMID 10852481; See PMID 7646819
An05g00520	Function: RNA helicase A is an abundant nuclear enzyme of human cells that unwinds double-stranded RNA in a 3' to 5' direction.; Function: the function of the RNA helicase A gene has been categorized as chromatin binding/helicase/double-stranded RNA binding.; Remark: DDX9 of H. sapiens is also called NDH2 or DEAD-box protein 9.; Remark: the maleless mle gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males.; Remark: the predicted A. niger protein contains two DEAD/DEAH box helicase motivs (PF00270, aa 675-708,740-841) of the DEAD and DEAH box helicases family,involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.; Similarity: the ORF shows also similarity to DNA or DNA/RNA helicases.; Title: strong similarity to RNA helicase A DDX9 -Homo sapiens; nucleus; See PMID 1653648
An05g00530	Induction: phosphorylation of the translation initiation factor eIF2 by protein kinase GCN2 leads to increased translation of the transcriptional activator GCN4 in amino acid-starved cells.; Remark: the H. sapiens HsGCN1 protein shows strong similarity and functional relationship to the yeast orthologue GCN1, which serves as a component of a protein complex required for the stimulation of GCN2 kinase activity under starvation conditions and where the most investigations have taken place.; Title: strong similarity to translational regulator HsGCN1 - Homo sapiens; cytoplasm; See PMID 11350982; See PMID 9234705
An05g00540	Remark: the systematical name of the S. cerevisiae L19 gene is YBL0424.; Similarity: the predicted A. niger protein shows a domain nearly identical with the ribosomal protein L19e motiv PF01280 (aa 13 - 160).; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L19 - Saccharomyces cerevisiae; cytoplasm; See PMID 11551941; See PMID 7725803
An05g00570	Title: strong similarity to hypothetical protein CAD60747.1 - Podospora anserina
An05g00580	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An05g00590	Remark: the ORF is truncated and contains no start-codon due to the border of the contig.; Title: questionable ORF [truncated ORF]
An05g00600	Similarity: some local weak similarity to unrelated proteins with completely different lengths.; Title: similarity to hypothetical protein encoded by An06g02450 - Aspergillus niger
An05g00610	Similarity: the prnA protein of A. nidulans is a transcriptional activator containing a fungal Zn binuclear cluster; the predicted ORF have not such functional domain.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360
An05g00620	Similarity: the protein contains three PROSITE motifs with functional significance, but no protein known to contain such functional domains shows similarity to the predicted ORF.
An05g00625	Title: weak similarity to hypothetical protein isof - Caenorhabditis elegans
An05g00630	Similarity: the relatively significant BLASTP scores are due to the exceptional lenght of the predicted protein; the alignments are very bad and mainly due to the relative high content of low-complexity region; no BLASTP hit can be considered significant.; Title: strong similarity to hypothetical protein AAN10358.2 - Drosophila melanogaster
An05g00640	Function: ALR2 of S. cerevisiae mediates the transport of Mg2+ and other divalent cations.; Function: overexpression of ALR2 of S. cerevisiae confers resistance to aluminum ion.; Remark: ALR2 of S. cerevisiae is also called YFL050C.; Similarity: the N-terminal part of the predicted ORF shows no similarity to ALR2 and other proteins.; Title: strong similarity to divalent cation transprter Alr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 10220002; See PMID 9430719
An05g00670	Similarity: the similarity to VAC7 of S. cerevisiae involves only the C-terminal third of the predicted protein and the alignment contains 25% of gaps.; Title: weak similarity to vacuolar protein Vac7 -Saccharomyces cerevisiae; See PMID 9700156; See PMID 9763421; See PMID 8929562; See PMID 9372916
An05g00680	Title: questionable ORF
An05g00690	Title: strong similarity to hypothetical protein EAA58367.1 - Aspergillus nidulans
An05g00720	Function: the facB gene of A. nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: the ORF shows similarity to several transcription factors with unknown fucntion.; Similarity: the similarity of the ORF to facB of A. nidulans is restricted to the N-terminal part, ending with amino acid 262 of the ORF.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126; See PMID 10483720
An05g00730	Induction: S. cerevisiae HXT genes are inducible by glucose.; Remark: S. cerevisiae has 20 genes for known or putative hexose transporters.; Repression: S. cerevisiae HXT gene transcription is repressed in the absence of glucose.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; plasma membrane; See PMID 10477308; See PMID 7862149
An05g00740	Remark: the ORF has a suboptimal intron-exon structure.
An05g00750	Remark: ribosomal protein L41 of C. utilis is also called 60S ribosomal protein L44.; Remark: the 56th amino acid residue of L41 is responsible for the ribosome inhibitor cycloheximide sensitivity of various organisms.; Similarity: the ORF overlaps with A. niger ESTs an_3001 database entry EMBLEST:BE758800, an_3087 entry EMBLEST:BE758839 and PATENTDNA:AAF11322 EST SEQ ID NO:3845.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L41 - Candida utilis; cytoplasm; See PMID 1729213
An05g00760	Title: strong similarity to hypothetical protein EAA57966.1 - Aspergillus nidulans
An05g00770	Remark: due to the presence of a ribosomal protein L41 homologue (ORF 42CK) in proximity to this ORF, it is suggested that this region of the sequence was originally similar to known genes, which produce precursor proteins consisting of a single copy of ubiquitin fused to a C-terminal extension protein (CEP), e. g. ribosomal protein S27a.; Remark: pub2 of A. thaliana is also called ubiquitin-like protein 7, UBQ10 or PUB1.; Similarity: the ORF is half as long as the polyubiquitin 2 of A. thaliana, therefore it contains only one ubiquitin unit.; Title: strong similarity to polyubiquitin 2 PUb2 -Arabidopsis thaliana; See PMID 2538756
An05g00780	Function: Ela1 of S. cerevisiae is an transcription elongation factor, which is necessary for RNA elongation from the RNA polymerase II promoter.; Remark: Ela1 of S. cerevisiae is also called YNL230C or N116.; Title: similarity to transcription elongation factor Ela1 - Saccharomyces cerevisiae; See PMID 10430890
An05g00790	Function: nodulin proteins are induced during a symbiotic plant-microbe interaction process and GmNOD53b of G. max is probably involved in cell-cell contact.; Induction: the expression of GmNOD53b of G. max coincides with the onset of nitrogen fixation.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to nodulin GmNOD53b -Glycine max [truncated ORF]; See PMID 10065559; See PMID 2279354
An05g00800	Remark: the N-terminal part of the ORF lies on the adjacent contig An05c0030 as ORF An05g00790.; Remark: the ORF is N-terminally truncated due to contig border.; Title: similarity to nodulin GmNOD53b - Glycine max [truncated ORF]
An05g00810	Function: tbca of O. cuniculus participates in the tubulin folding process by interacting with a folding intermediate of beta-tubulin.; Remark: is also called TCP1-chaperonin cofactor A,tubulin-folding cofactor or CFA.; Similarity: the ORF overlaps with A. niger EST an_2839 database entry EMBLEST:BE759901.; Title: similarity to tubulin-specific chaperone A TBCA - Oryctolagus cuniculus
An05g00820	Title: similarity to hypothetical protein SPCC24B10.11c - Schizosaccharomyces pombe
An05g00830	Title: similarity to hypothetical protein T12G13.60 - Arabidopsis thaliana
An05g00840	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An05g00850	Similarity: theORF shows similarity to several multidrug-efflux transporter homologues from different species.; Title: strong similarity to multidrug resistance transporter fnx1p - Schizosaccharomyces pombe; See PMID 9710608
An05g00860	Remark: the ORF is questionable due to its short lenght of only 119 amino acids.; Title: questionable ORF
An05g00870	Function: uaY of A. nidulans codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization by binding to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 9218768
An05g00880	Remark: dnaJ protein homolog; Title: strong similarity to dnaJ protein homolog Scj1 - Saccharomyces cerevisiae; See PMID 8016869
An05g00900	Title: strong similarity to hypothetical protein SPAC32A11.02c - Schizosaccharomyces pombe
An05g00910	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An05g00930	Catalytic activity: NADP-dependent malate dehydrogenases convert S)-malate + NADP(+) <=> pyruvate + CO(2) + NADPH.; Function: NADP-dependent malate dehydrogenases are involved in the metabolism of pyruvate by converting malate to pyruvat.; Title: strong similarity to NADP-dependent malate dehydrogenase mdh - Homo sapiens
An05g00950	Remark: nadA of A. parasiticus is part of a well-defined gene cluster (not yet identified in A. niger) related to sugar utilization in A. parasiticus and is located in proximity to an aflatoxin biosynthetic pathway gene cluster.; Similarity: the ORF shows similarity to different NADH-dependent oxidoreductases with various cellular function.; Title: strong similarity to NADH oxidase nadA -Aspergillus parasiticus; See PMID 10978525
An05g00960	Function: imp3 of S. cerevisiae is involved in pre-rRNA processing, e. g. the pre-18S rRNA, by associating with the, Mpp10.; Remark: imp3 of S. cerevisiae is identical to YHR148w, which was originally believed to be a ribosomal protein.; Similarity: the ORF shows similarity to S4-like ribosomal proteins from different species, which have a similar S4 domain, that mediates RNA binding.; Title: strong similarity to U3 small nucleolar ribonucleoprotein Imp3 - Saccharomyces cerevisiae; nucleus
An05g00970	Similarity: the ORF shows unspecific similarity to serine-rich proteins.
An05g00980	Function: uaY of A. nidulans codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization by binding to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.; Similarity: the ORF is similar to 56WK on the same contig.; Similarity: the ORF shows similarity to transcriptional activators, which are probable involved in control of metabolism.; Similarity: the predicted ORF is 502 amino acids shorter at the N-terminus and 163 aa shorter at the C-terminus thanor UaY of E. nidulans.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 9218768
An05g00990	Catalytic activity: mdh of M. fervidus catalyses malate + NAD(+) <=> oxaloacetate + NADH (EC 1. 1. 1. 37) and malate + NADP(+) = oxaloacetat + NADPH (EC 1. 1. 1. 82).; Remark: mdh of M. fervidus has a low selectivity to the coenzyme NAD(H) or NADP(H), and catalyzes the reduction of oxaloacetate to malate more efficiently than the reverse reaction.; Remark: two isozymes of malate dehydrogenase exist,one which is located in the mitochondrial matrix and the other in the cytoplasm, additionally, fungi and plants also harbor a glyoxysomal form, which functions in the glyoxylate pathway.; Similarity: the ORF shows similarity to some NAD(+)-dependent malate dehydrogenases, especially from bacteria.; Title: strong similarity to malate dehydrogenase mdh - Methanothermus fervidus; See PMID 2110059
An05g01000	Similarity: the ORF shows weak similarity to SC6A11. 07c, a putative secreted nucleosidase of S. coelicolor.; Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster
An05g01010	Catalytic activity: plb1 of P. notatum catalyzes e. g. 2-lysophosphatidylcholine + H(2)O <=> glycerophosphocholine + a fatty acid anion.; Function: phospholipase B is involved in the release of fatty acids by hydrolyzing both the acyl ester bonds of diacylphospholipids (diacyl-hydrolase) and the acyl ester bond of monoacylphospholipids or lysophospholipids.; Function: plb1 of P. notatum has intrinsic lysophospholipase and phospholipase B activities.; Title: strong similarity to lysophospholipase plb1 -Penicillium notatum; extracellular/secretion proteins; See PMID 5402; See PMID 1722456
An05g01020	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An05g01030	Title: similarity to hypothetical protein encoded by An16g01380 - Aspergillus niger
An05g01040	Similarity: the ORF shows similarity to the putative zinc-finger transcription regulator protein SPAC821. 07c of S. pombe.; Title: similarity to hypothetical protein CAD60719.1 - Podospora anserina
An05g01060	Function: HTS1 of C. carbonum is a cyclic peptide synthetase, which catalyses the production of HC-toxin, a cyclic tetrapeptide.; Function: HTS1 of C. carbonum is able to activate L-proline, thiosterifies L-proline, and epimerizes it to D-proline; Induction: expression of HTS1 of C. carbonum is up regulated during spore germination.; Similarity: the ORF shows strong similarity to several peptide synthetase involved in synthesis of various toxins.; Title: strong similarity to HC-toxin synthase HTS1 -Cochliobolus carbonum; See PMID 1281482; See PMID 7655067
An05g01070	Function: RTA1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation and probably improves the growth of heterologous microorganisms on media containing molasses.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An05g01080	Similarity: the ORF shows similarity to ankyrin-repeats containing proteins.; Similarity: the similarity of the ORF to AKT1 of A. thaliana is restricted to its C-terminal part, starting with amino acid 241 and concering a region, which is homologues to the ankyrin-repeat domain of AKT1 (aa 517 to 679).; Title: weak similarity to potassium channel protein AKT1 - Arabidopsis thaliana
An05g01090	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 110 amino acids.; Title: questionable ORF
An05g01100	Function: TOXF is specifically required for HC-toxin production and pathogenicity.; Phenotype: a strain of C. carbonum with all copies of TOXF disrupted grew normally but lost HC-toxin production and pathogenicity.; Remark: the cyclic tetrapeptide HC-toxin is required for pathogenicity of the filamentous fungus Cochliobolus carbonum on maize.; Similarity: TOXF has moderate homology to many known or putative branched-chain-amino-acid transaminases from various species.; Title: strong similarity to HC-toxin biosynthesis protein TOXF - Cochliobolus carbonum; See PMID 10627051
An05g01110	Function: YCF1 is required for cadmium resistance.; Phenotype: S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Remark: members of the ATP binding cassette (ABC) protein superfamily transport a variety of substances across biological membranes, including drugs, ions, and peptides.; Similarity: YCF1 shows extensive homology to both the human multidrug resistance-associated protein (MRP1) and the cystic fibrosis transmembrane conductance regulator (hCFTR).; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334
An05g01120	Catalytic activity: TRI11 catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: TRI11 from F. sporotrichioides is involved trichothecene biosynthesis.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 belongs to the cytochrome p450 family.; Title: strong similarity to hypothetical cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An05g01140	Title: weak similarity to hypothetical protein encoded by An14g07170 - Aspergillus niger
An05g01160	Similarity: the ORF shows similarity to methyltransferases.; Title: weak similarity to air bubble protein gvpA-gvpD-41 from patent CN1331110-A - Unclassified organism
An05g01170	Function: ArsH from Th. ferrooxidans is not required for arsenic resistance in E. coli.; Title: strong similarity to arsenical resistance protein ArsH - Thiobacillus ferrooxidans; See PMID 10788346
An05g01180	Title: strong similarity to hypothetical protein CAD71085.1 - Neurospora crassa
An05g01190	Title: questionable ORF
An05g01200	Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181
An05g01210	Function: biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway requires NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate by Ayr1p.; Localization: Ayr1p is a major component of lipid particles and is also found in the endoplasmic reticulum.; Pathway: Ayr1p is involved in phosphatidic acid biosynthesis.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10617610
An05g01220	Title: similarity to hypothetical protein encoded by An06g00680 - Aspergillus niger
An05g01250	Title: weak similarity to protein fragment SEQ ID NO:23867 from patent EP1033405-A2 - Arabidopsis thaliana
An05g01260	Title: similarity to hypothetical protein encoded by An05g01250 - Aspergillus niger
An05g01270	Remark: antibodies against GOR are present in individuals with hepatitis C (non-A, non-B hepatitis).; Title: weak similarity to recombinant antigen GOR -Pan troglodytes; See PMID 1701012
An05g01290	Function: HXT3 can confer growth on medium containing at least 1% glucose.; Induction: HXT3 is maximally expressed after entry into stationary phase.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8417358
An05g01300	Title: weak similarity to site specific integrase from patent WO9419460-A - bacteriophage phi LC3
An05g01320	Function: man1 plays a role in fructose and mannose metabolism.; Title: strong similarity to mannase man1 -Aspergillus aculeatus; See PMID 7987261
An05g01330	Title: weak similarity to hypothetical protein CC0892 - Caulobacter crescentus
An05g01340	Title: weak similarity to regulator protein Arg81 -Saccharomyces cerevisiae
An05g01360	Title: weak similarity to zinc binuclear cluster protein sequence #105 from patent WO200224865-A2 -Unclassified organism
An05g01380	Function: linX is involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis.; Similarity: linX show homology to members of the short-chain alcohol dehydrogenase family.; Title: strong similarity to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linX - Sphingomonas paucimobilis; See PMID 7515041
An05g01400	Title: strong similarity to hypothetical protein encoded by An08g03760 - Aspergillus niger
An05g01410	Catalytic activity: ACX2 of A. thaliana is active with long-chain acyl-CoAs; maximal activity with C18-CoA.; Localization: ACX2 of A. thaliana contains a peroxisomal targeting signal and, according to other known homologues, probably is located in the peroxisome.; Pathway: fatty acid beta-oxidation.; Title: similarity to acyl-CoA oxidase ACX2 -Arabidopsis thaliana; See PMID 10571860
An05g01420	Title: weak similarity to hypothetical protein encoded by An08g08120 - Aspergillus niger
An05g01430	Function: motA of E. coli is required for flagellar rotation.; Title: weak similarity to chemotaxis protein motA -Escherichia coli; See PMID 6090403
An05g01440	Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; plasma membrane; See PMID 10320578
An05g01450	Catalytic activity: 2-nitropropane dioxygenase of N. crassa catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds; the preferred substrate is 2-nitropropane; the reaction stoichiometry is 2CH3CH(NO2)CH3 + O2 --> 2CH3COCH3 + 2HNO2.; Catalytic activity: nitroethane and 1-nitropropane can act as donors, more slowly.; Complex: the Neurospora enzyme contains flavin mononucleotide as a prosthetic group.; Title: strong similarity to 2-nitropropane dioxygenase ncd-2 - Neurospora crassa; See PMID 9501443
An05g01470	Similarity: a local weak similarity to a putative malate oxidoreductase of A. thaliana cannot be considered significant due to length difference and absence of any structural domain compatible with oxydoreductase activity in the predicted ORF.; Title: similarity to hypothetical protein encoded by An13g01730 - Aspergillus niger
An05g01480	Similarity: the predicted ORF shows similarity also to bem46 of S. pombe, annotated as supressor of bem1/bud5,but without published characterization.; Title: similarity to Kidney injury associated molecule HW073 from patent WO9853071-A1 - Rattus sp.
An05g01490	Title: strong similarity to hypothetical protein PA3762 - Pseudomonas aeruginosa
An05g01500	Function: CYHR of C. maltosa confers resistance to cycloheximide.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Localization: CYHR of C. maltosa is an integral membrane protein.; Remark: the predicted protein also shows strong similarity to a protein involved in cephalosporin C biosynthesis of Acremonium chrysogenum (Patent JP09009966-A), which is only poorly described.; Similarity: CYHR of C. maltosa belongs to the car1/cyhr subfamily.; Similarity: CYHR of C. maltosa belongs to the multidrudrug resistance family.; Title: strong similarity to cyclohexamide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An05g01510	Title: questionable ORF
An05g01520	Title: similarity to hypothetical conserved protein aq_1250 - Aquifex aeolicus
An05g01530	Title: questionable ORF
An05g01550	Remark: the ORF has an unusual exon/intron structure for A. niger.
An05g01560	Function: 2,3-Dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase (B2,3D) catalyzes the second step in the biphenyl degradation pathway in C. testosteroni.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: similarity to 2,3-dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase bphB - Comamonas testosteroni; See PMID 8702262
An05g01580	Title: weak similarity to hypothetical sensor protein XF2535 - Xylella fastidiosa
An05g01590	Similarity: weak local similarity to proteins with completely different length.
An05g01600	Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the predicted ORF shows similarity to several putative transcription factors.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; See PMID 8889513; See PMID 8967907
An05g01610	Function: zeaxanthin epoxidase of N. plumbaginifolia is involved in the biosynthesis of the plant hormone abscisic acid.; Remark: closest manual BLASTP homologue: PIR:S69548.; Similarity: the C-terminal part of the predicted protein shows no similarity.; Similarity: the predicted ORF shows strong similarity to many hypothetical and known monooxygenases.; Title: similarity to zeaxanthin epoxidase precursor ABA2 - Nicotiana plumbaginifolia; See PMID 8665840; See PMID 1444267
An05g01620	Function: the homolog Podospora anserina het-e gene is involved in vegetative incompatibility. co-expression of antagonistic alleles of het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina
An05g01640	Title: strong similarity to hypothetical protein sll1376 - Synechocystis sp.
An05g01650	Function: the A. terreus homolog LovD encodes a transesterase enzyme that catalyzes attachment of the 2-methylbutyric acid to monacolin J in the final step of the synthesis of lovastatin, an HMG-CoA reductase inhibitor.; Title: strong similarity to transesterase lovD from patent WO200037629-A2 - Aspergillus terreus; See PMID 10334994
An05g01660	Function: the S. cerevisiae homolog gene PDR5 encodes a membrane protein of the ATP-binding-cassette (ABC) superfamily, which is functioning as a drug extrusion pump with multiple pleiotropic substrates.; Induction: expression of S. cerevisiae Pdr5p is regulated by the pleiotropic drug resistance (PDR) network. transcriptional regulator are Pdr1p, Pdr3p, Pdr7p, and Pdr9p, which also control transcription of several other target genes, many of them also ABC transporter proteins like SNQ2, STE6, PDR10, PDR11 and YOR1.; Title: strong similarity to pleiotropic drug resistance protein Pdr5 - Saccharomyces cerevisiae; plasma membrane
An05g01680	Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe
An05g01700	Function: the homolog yeast cadmium factor Ycf1p is a vacuolar ATP binding cassette (ABC) transporter required for heavy metal and drug detoxification.; Similarity: S. cerevisiae Ycf1p is strongly related to the human multidrug-associated protein (MRP1) and cystic fibrosis transmembrane conductance regulator (CFTR).; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; vacuole
An05g01710	Title: weak similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An05g01720	Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An05g01740	Function: the S. cerevisiae homolog Put4p is a high affinity proline permease, that also transports alanine and glycine.; Localization: S. cerevisiae Put4p is predominantly localized in an internal storage compartment. under nitrogen limited growth conditions, Put4p sorting is redirected to the cell surface.; Title: strong similarity to proline transporter Put4 - Saccharomyces cerevisiae; plasma membrane
An05g01750	Complex: S. cerevisiae Hoc1p is a subunit of the Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex.; Function: the S. cerevisiae homolog Hoc1p is a Golgi localized mannosyltransferase involved in cell wall integrity.; Golgi; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae
An05g01760	Function: the C. gloeosporioides homolog CHIP3 is potentially involved in differentiation into the infection structure appressorium.; Induction: C. gloeosporioides CHIP3 is induced by a 2-h hard-surface contact.; Title: similarity to hard surface induced protein 3 chip3 - Glomerella cingulata
An05g01780	Title: similarity to hypothetical protein SA1981 -Staphylococcus aureus
An05g01810	Catalytic activity: 2 2-nitropropane + O(2) <=> 2 acetone + 2 nitrite.; Function: the N. crassa homolog ncd-2 is a 2-nitropropane dioxygenase that catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds.; Remark: the homolog N. crassa ncd-2 contains flavin mononucleotide as a prosthetic group.; Title: strong similarity to 2-nitropropane dioxygenase precursor ncd-2 - Neurospora crassa
An05g01820	Title: strong similarity to hypothetical protein yphH - Lactococcus lactis
An05g01830	Title: strong similarity to transcription repressor Rdr1 - Saccharomyces cerevisiae
An05g01840	Function: the S. cerevisiae homolog Tpo1p is a polyamine transport protein on the vacuolar membrane. Tpo1p regulates cytoplasmic concentration of polyamines and therefore mediates cell resistance by transport into the vacolar lumen.; Title: strong similarity to vacuolar polyamine transporter Tpo1p from patent WO200107592-A2 -Saccharomyces cerevisiae; vacuole
An05g01850	Function: monocarboxylate transporter are involved in the transport of e. g. lactate and pyruvate.; Title: similarity to monocarboxylate transporter MCT2 - Homo sapiens
An05g01860	Remark: the S. cerevisiae homolog orf Z37509 is located in the 3' non-coding region of MEL3-MEL10 genes and is most likely not expressed efficiently if at all.; Similarity: the ORF shows similarity to the superfamily of amidases.; Title: strong similarity to hypothetical amidase Z37509 - Saccharomyces cerevisiae
An05g01870	Function: the C. albicans homolog CPY encodes the vacuolar serine proteinase carboxypeptidase y. carboxypeptdiase y is synthesized as a precursor form that is processed in the vacuolar lumen. CPY exhibits the major vacuolar proteolytic activity.; Title: strong similarity to carboxypeptidase y CPY -Candida albicans; vacuole
An05g01880	Similarity: the ORF shows strong similarity to expressed sequence tag an_0938 from Aspergillus niger.; Title: strong similarity to hypothetical chloroperoxidase cpo - Agaricus bisporus
An05g01890	Similarity: the ORF shows similarity to mRNA sequence of cDNA clone 3067 of A. niger. The ORF sequence deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to hypothetical protein related to host-specific AK-toxin Akt2 B23L21.350 -Neurospora crassa
An05g01900	Remark: similarity is exclusively due to DSD repeats.; Title: weak similarity to fibrinogen-binding protein clfA - Staphylococcus aureus
An05g01910	Title: strong similarity to hypothetical protein encoded by An05g01900 - Aspergillus niger
An05g01940	Title: similarity to hypothetical protein CAG74385.1 - Erwinia carotovora
An05g01960	Title: similarity to hypothetical protein BAB49283.1 - Mesorhizobium loti
An05g01980	Function: Tto1 can transpose autonomously through reverse transcription.; Remark: Tto1 is one of the few active retrotransposons of plants.; Remark: a putative point mutation results in a premature STOP-codon.; Title: similarity to retrotransposon Tto1 -Nicotiana tabacum [putative sequencing error]; putative sequencing error; See PMID 8624443
An05g02000	Catalytic activity: L-Threonine + NAD+ = L-2-Amino-3-oxobutanoate + NADH.; Pathway: Glycine, serine and threonine metabolism.; Remark: contains Pfam alcohol dehydrogenase zinc domain from aa residue 13 to 320.; Similarity: similarity to various pro- and eukaryotic dehydrogenases (EC 1. 1. 1. -) generally involved in carbohydrate metabolism.; Title: strong similarity to L-threonine 3-dehydrogenase tdh - Escherichia coli
An05g02010	Function: the SUT1 protein from P. stipitis mediates glucose uptake.; Localization: integral membrane protein (by similarity).; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane
An05g02020	Similarity: contains Pfam Zn(2)-Cys(6) binuclear cluster domain from aa 24 to 62.; Similarity: similarities correspond to multiple cysteine and arginine repeats.; Title: weak similarity to negative acting factor naf - Fusarium solani; See PMID 7744822; See PMID 9139694
An05g02030	Catalytic activity: A 1,4-lactone + H(2)O <=> a 4-hydroxyacid.; Function: lactonohydrolases catalyse the hydrolysis of lactone compounds to hydroxy acids.; Title: strong similarity to lactonohydrolase from patent WO200028043-A2 - Fusarium venenatum
An05g02040	Catalytic activity: d-fructose 1,6-bisphosphate = glycerone-phosphate + d-glyceraldehyde 3-phosphate.; Cofactor: zinc (by similarity).; Pathway: sixth step in glycolysis.; Similarity: no similatity in N-terminus.; Similarity: the S. aureus Alf1 gene product belongs to class II fructose-bisphosphate aldolase family.; Title: strong similarity to fructose-bisphosphate aldolase Alf1 from patent WO200012678-A2 - Staphylococcus aureus
An05g02050	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP + = 3-oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: fatty acid biosynthesis.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase srb - Bacillus subtilis
An05g02060	Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Function: catalyzes the reduction of ethyl 4-chloro-3-oxobutanoate (COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate (CHBE), with a 100% enantiomeric excess.; Similarity: the C. magnoliae carbonyl reductase is also patented (patent WO9835025-A1) for its use to provide for sufficient production of optically active 3-hydroxybutanoate esters for use as synthetic intermediates for pharmaceuticals.; Title: strong similarity to carbonyl reductase (NADPH) S1 - Candida magnoliae; See PMID 10945260
An05g02070	Catalytic activity: alcohol + NADP(+) = aldehyde + NADPH.; Function: the R. norvegicus ALR protein catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3-dg).; Similarity: belongs to the aldo/keto reductase family.; Title: strong similarity to aldehydereductase ALR -Rattus norvegicus [putative frameshift]; putative frameshift; See PMID 8500767
An05g02090	Similarity: similarity is restricted to the central region of retrotransposable element tf2 of S. pombe,containing a Pfam-domain of Reverse transcriptase .; Similarity: the retrotransposable element tf2 of S. pombe has regional similarity to protease, reverse transcriptase, RNAse H and integrase from other retrotransposons and retroviruses.; Title: similarity to retrotransposable element tf2 155 kd protein - Schizosaccharomyces pombe; See PMID 8396547
An05g02100	Catalytic activity: endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units.; Gene-ID: amyA;amyB; Pathway: glycogen/starch degradation.; Remark: a nearly identical match (even on DNA level) was found to ORF An12g06930.; Similarity: the nucleotide sequences of amyA and amyB from A. niger are identical throughout all but the last few nucleotides of their respective coding regions.; See PMID 2340591
An05g02110	Similarity: the ORF shows similarity to plasmid NA2 DNA encoding neutral alpha-amylase patent WO8901969-A -Aspergillus niger. The homologous sequence includes preregion, promoter and upstream activating sequences.; Title: strong similarity to hypothetical protein encoded by An12g06940 - Aspergillus niger
An05g02120	Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID no. 7357 patent WO200056762-A2 of A. oryzae.; Title: strong similarity to hypothetical protein encoded by An12g06960 - Aspergillus niger
An05g02130	Title: similarity to heat shock protein 40 DnaJ -Methanosarcina thermophila; See PMID 10570966
An05g02140	Title: strong similarity to hypothetical protein encoded by An12g06610 - Aspergillus niger
An05g02160	Title: weak similarity to hypothetical myb-related protein 1 - Petunia hybrida
An05g02170	Catalytic activity: release of a C-terminal amino acid with a broad specificity.; Function: catalyzes also peptide synthesis.; Function: removes any amino acid from the c-terminus of a long peptide, digests preferentially peptides containing a positively charged residue in P1' position, as well as arginine, lysine or phenylalanine in P1 position of ester substrate.; Induction: in the following growth conditions: acidic ph, absence of nitrogen or carbon source.; Regulation: inhibited by Dfp, and Hg(Cl)2.; Similarity: belongs to peptidase family S10; also known as the serine carboxypeptidase family.; Title: strong similarity to serine-type carboxypeptidase F CPD-II - Aspergillus niger; vacuole
An05g02190	Function: isopenicillin N epimerase of S. clavuligerus catalyses the reversible isomerisation between isopenicillin and penicillin N.; Remark: the ORF is longer than cefD of S. clavuligerus (486 compared to 397 amino acids).; Similarity: the ORF shows similarity to members of the (pyridoxal-phosphate-dependent) aminotransferase family.; Title: similarity to isopenicillin N epimerase cefD - Streptomyces clavuligerus
An05g02200	Function: M. musculus kinesin KIF21B is a microtubule-dependent motor protein for transport of essential cellular components along dendritic microtubules.; Similarity: similarity is restricted to N-terminus.; Title: similarity to kinesin Kif21b - Mus musculus; cytoskeleton; See PMID 10225949
An05g02210	Function: the PA45 gene product of the T. cruzi is a co-factor-independent proline racemase, the active site is necessary for mitogenic activity.; Title: strong similarity to B-cell mitogen precursor PA45 - Trypanosoma cruzi; See PMID 10932226
An05g02220	Catalytic activity: (S)-2-Haloacid + H2O = (R)-2-Hydroxyacid + Halide.; Function: catalyzes hydrolytic cleavage of halogen-carbon bonds of C2-halogenated alkanoic acids to yield 2-hydroxy or 2-oxo acids.; Title: similarity to 2-haloacid dehalogenase -Pseudomonas putida; See PMID 7764511
An05g02230	Title: strong similarity to hypothetical protein PA1259 - Pseudomonas aeruginosa
An05g02240	Function: the nerA gene product of A. radiobacter removes central or terminal nitro-groups from nitroglycerin and related esters as nitrite.; Similarity: contains FMN oxidoreductase domain.; Similarity: similarities to pro- and eukaryotic xenobiotic reductases (NADPH dehydrogenases, EC 1. 6. 99. 1).; Similarity: similarity to morphinone reductase of P. putida and old yellow enzyme (OYE) from S. cerevisiae.; Similarity: the nerA gene product of A. radiobacter belongs to the alpha/beta barrel flavoprotein group of proteins.; Title: strong similarity to glycerol trinitrate reductase nerA - Agrobacterium radiobacter; See PMID 9401040
An05g02250	Similarity: similarities predominantly correspond to multiple serine and threonine residues.; Title: similarity to hypothetical serine-threonine rich protein - Schizosaccharomyces pombe
An05g02260	Catalytic activity: xylitol + NAD(+) <=> D-xylulose + NADH.; Cofactor: zinc 2+; Similarity: similarities to L-Iditol 2-dehydrogenases (EC 1. 1. 1. 14).; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 10661867
An05g02270	Title: strong similarity to hypothetical protein B15I20.50 - Neurospora crassa [putative frameshift]; putative frameshift
An05g02280	Function: the Alcaligenes esterase is capable of resolving paroxetine methyl ester and/or ethyl ester to give an enantiomer excess of the (-) isomer greater than 90%.; Remark: the Alcaligenes esterase can be used for the stereospecific hydrolysis of paroxetine esters for use in the production of an active paroxetine isomer.; Title: similarity to esterase from patent WO9802556-A2 - Alcaligenes sp.
An05g02300	Title: similarity to secreted protein SEQ ID NO:127 from patent WO200061779-A1 - Homo sapiens
An05g02310	Alternative name: BCG21, CSG1; Function: the S. cerevisae Sur1 gene product is necessary for mannosylation of the sphingolipid inositolphosphorylceramide.; Pathway: mannose-inositol-P-ceramide (MIPC) metabolism.; Remark: the S. cervisiae Sur1 gene product suppresses certain phenotype of rvs161 mutants including reduced viability upon starvation.; Remark: the S. cervisiae Sur1 gene product suppresses the Ca(2+)-sensitive phenotype of the csg2 mutant.; Title: strong similarity to sphingolipid metabolism Sur1 - Saccharomyces cerevisiae; See PMID 7785328; See PMID 7854312; See PMID 9323360
An05g02320	Function: the P. Pastoris enzyme is involved in sugar chain extension of glycoproteins.; Title: similarity to alpha-1,6-mannosyltransferase from patent JP09003097-A - Pichia pastoris
An05g02330	Function: the cap59 gene product is essential for capsule formation and for pathogenicity of C. neoformans.; Similarity: similarity is restricted to the central region of the protein.; Title: similarity to capsule protein CAP59 -Cryptococcus neoformans; See PMID 8007987
An05g02340	Catalytic activity: 4 benzenediol + o(2) = 4 benzosemiquinone + 2 H(2)O.; Cofactor: binds 4 cu-ions per molecule. Three distinct Cu centres known as type1 or blue, type 2 or normal, and type 3 or coupled binuclear (by similarity).; Function: lignin degradation and detoxification of lignin-derived products (probable).; Localization: secreted (potential).; Similarity: belongs to the family of multicopper oxidases.; Similarity: contains 3 plastocyanin-like domains.; Title: strong similarity to precursor of laccase -Neurospora crassa; See PMID 2947240; See PMID 2961749
An05g02350	Gene-ID: Arsa-48; Remark: Arsa-48 from A. niger is differentially expressed in the pellet morphology relative to the filamentous morphology.
An05g02360	Similarity: similarity is restricted to N-terminus.; Title: strong similarity to hypothetical protein encoded by An18g01530 - Aspergillus niger
An05g02370	Function: TRI101 of F. sporotrichioides 3-O-acetylates trichothecene mycotoxins (such as T-2 toxin), it converts isotrichodermol to isotrichodermin.; Pathway: TRI101 of F. sporotrichioides is necessary for the biosynthesis of T-2 toxin.; Phenotype: disruption of TRI101 of F. sporotrichioides leads to accumulation of T-2 toxin biosynthesis products.; Remark: a putative sequencing error was corrected by introducing a frame shift of 1bp.; Remark: trichothecene mycotoxins are toxic for eukaryotic organisms (they act as protein synthesis inhibitors); 3-O-acetylation, however, converts the trichothecene mycotoxins in untoxic compounds; thus, TRI101 acts for F. sporotrichioides, which produces trichothecenes, as a resistance protein.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides [putative frameshift]; putative frameshift; See PMID 9762900; See PMID 10583973
An05g02380	Function: vbs of A. parasiticus cyclizes the versiconal hemiacetal to an optically active product whose absolute configuration is crucial to the interaction of aflatoxin B1 with DNA.; Pathway: vbs of A. parasiticus is a crucial enzyme in the aflatoxin biosynthetic pathway.; Remark: aflatoxin B1 is a potent environmental carcinogen.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: the ORF shows similarity to A. niger glucose oxidase patent US5516671-A and patent WO9514784-A.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8784203; See PMID 8995367
An05g02390	Function: 6-HDNO (EC: 1. 5. 3. 6.) of Arthrobacter oxidans oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Induction: 6-HDNO of A. oxidans is induced by nicotine.; Pathway: 6-HDNO of A. oxidans is involved in nicotine degradation.; Similarity: the ORF shows local similarity to 6-HDNO of Arthrobacter oxidans: the Arthrobacter protein is shorter in length (458 compared to 642 amino acids) and the alignment between the two proteins encompasses only about 150 amino acids.; Similarity: the ORF shows much stronger and overall similarity to the probable isoamyl alcohol oxidase mreA of A. oryzae.; Similarity: the ORF shows similarity to some unspecified oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516
An05g02400	Function: NUM1 of S. cerevisiae controls cytoplasmic microtubule functions and nuclear migration through the bud neck in anaphase cells.; Function: NUM1 of S. cerevisiae controls nuclear migration by forming dynein-interacting cortical cytoplasmic microtubule capture sites at both cellular poles.; Similarity: NUM1 of S. cerevisiae is about 13 times longer than the ORF; additionally, the alignment between the two proteins encompasses only about 100 amino acids.; Title: weak similarity to nuclear migration protein Num1 - Saccharomyces cerevisiae; See PMID 1745235
An05g02410	Catalytic activity: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.; Function: GUSB of C. familiaris degrades glycosaminoglycans.; Pathway: GUSB of C. familiaris is involved in starch and sucrose metabolism and glycosaminoglycan degradation.; Phenotype: mutation of GUSB in C. familiaris leads to the lysosomal storage disease mucopolysaccharidosis VII,which is characterized by accumulation of glycosaminoglycans in the lysosomes.; Remark: GUSB of C. familiaris belongs to family 2 of glycosyl hydrolases.; Similarity: GUSB of C. familiaris has the same length as the ORF; however, about 170 C-terminal amino acids are not included in the alignment between the two proteins.; Title: strong similarity to beta-glucuronidase GUSB - Canis lupus; lysosome; See PMID 9987917
An05g02420	Function: pth11 of the phytopathogenic fungus M. grisea is involved in host surface recognition.; Localization: pth11 of M. grisea was localized to the cell membrane and vacuoles.; Phenotype: mutants of pth11 of M. grisea are nonpathogenic due to a defect in appressorium differentiation.; Remark: pth11 of M. grisea is presumably not required for appressorium morphogenesis but is involved in host surface recognition.; Similarity: pth11 of M. grisea is much longer than the ORF (631 compared to 372 amino acids); the two proteins show similarity only at an N-terminal stretch of 265 amino acids.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An05g02430	Remark: the ORF overlaps with ~25 C-terminal nucleotides of the A. niger pgaC gene (in EMBL:ANPGAC and in PATENTDNA:Q11274) of the neighbouring ORF (cqnw. 00. tfa_105wk).
An05g02440	Catalytic activity: pgaC of A. niger hydrolysis randomly 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: pgaC of A. niger is involved in the degradation of pectin (a polygalacturonide).; Gene-ID: pgaC; Remark: in PIR S24156 pgaC is described as protein of A. nidulans. This is presumably a mistake, since the linked EMBL sequence (with identical protein sequence) and the linked PubMed article describe pgaC as an A. niger protein.; Remark: pgaC of A. niger belongs to family 28 of glycosyl hydrolases (polygalacturonases).; Remark: pgaC of A. niger is also called polygalacturonase III.; Similarity: the ORF is identical to pgaC of A. niger with the exception of one additional alanine at position 20.; Similarity: the ORF overlaps with the A. niger prepro-polygalacturonase C from patent EP421919-A.; See PMID 1511691
An05g02450	Function: bhaA of A. mediterranei is a halogenase involved in the biosynthesis of the glycopeptide antibiotic balhimycin.; Similarity: the ORF shows local similarity to bhaA of A. mediterranei: the two proteins overlap N-terminally (up to amino acid 350).; Title: similarity to halogenase bhaA from patent DE19926770-A1 - Amycolatopsis mediterranei; See PMID 10390204
An05g02460	Similarity: the ORF is 286 amino acids longer at the N-terminus than the hypothetical protein TM1177 of T. maritima.; Similarity: the ORF shows weak similarity to putative hydrolases.; Title: similarity to hypothetical conserved protein TM1177 - Thermotoga maritima
An05g02470	Function: The YCF1 gene from S. cerevisiae is required for cadmium resistance.; Remark: S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Similarity: YCF1 of S. cerevisiae belongs to the ATP-binding transport family (ABC transporters) and the MDR subfamily.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334; See PMID 10790694
An05g02480	Title: similarity to hypothetical protein PA2336 -Pseudomonas aeruginosa
An05g02490	Function: FacB of A. nidulans is a regulatory gene involved in acetamide and acetate utilisation.; Remark: FacB of A. nidulans is probably a DNA-binding transcriptional activator.; Remark: Similarity to FacB is restricted to N-terminal part of protein.; Similarity: FacB of A. nidulans has a N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, a leucine zipper-like heptad repeat motifs and central and C-terminal acidic alpha-helical regions.; Similarity: the predcited ORF show similarity to several transciption factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An05g02500	Title: strong similarity to hypothetical protein HI0753 - Synechocystis sp.
An05g02510	Title: strong similarity to galactose-proton symporter galP - Escherichia coli; See PMID 6300086
An05g02520	Title: strong similarity to hypothetical protein SCD10.11 - Streptomyces coelicolor
An05g02530	Function: the formyl-CoA transferase frc from Oxalobacter formigenes catalyzes the transfer of CoA from formyl-CoA to either oxalate or succinate.; Pathway: in Oxalobacter formigenes oxalic acid, a highly toxic by-product of metabolism, is catabolized by utilizing an activation-decarboxylation reaction which yields formate and CO2. The formyl-CoA transferase frc is involved at this detoxification step.; Similarity: Strong similarity to N-terminal part of many hypothetical proteins, hypothetical fatty acid co-A racemases and frc of O. formigenes.; Title: similarity to formyl-CoA transferase frc -Oxalobacter formigenes; See PMID 9150242; See PMID 2361939
An05g02540	Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: Laccase I from E. nidulans is a p-diphenol oxidase which is needed for synthesis of green conidial pigment.; Function: Laccases are a group of multi-copper proteins of low specificity acting on both catechol and p-benzenediol, and often acting also on aminophenols and phenylenediamine.; Function: The laccase I from E. nidulans catalyzes the oxidation of benzendiol to benzosemiquinone by molecular oxygen.; Remark: the 1990 decribed (Pubmed 2192364) yA gene from E. nidulans encodes the previous 1982 purified laccase I enzyme (Pubmed 7050088), which differs from the laccase II enzyme (Pubmed 6341366).; Title: strong similarity to laccase I precursor yA -Aspergillus nidulans; See PMID 7050088; See PMID 2192364; See PMID 2659435
An05g02550	Function: HOL1 of S. cerevisiae, which belongs to th multidrug efflux transporters family, seems also to be involved in ions transport.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows similarity to members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8543057; See PMID 8955402; See PMID 9046086; See PMID 9348664; See PMID 2405251
An05g02560	Function: amdA in E. nidulans regulates the expression of the gene encoding acetamidase, amdS.; Similarity: the predicted ORF contains also two leucine-zipper motifs, common to transcription regulators.; Similarity: the similarity of the predicted ORF to amdA of E. nidulans and other transcription factors is mainly due to the presence of a C2H2 zinc-finger motiv.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297
An05g02570	Catalytic activity: 3-(3-hydroxyphenyl)propionate + NADH + O2 <=> H2O + 3-(2,3-dihydroxyphenyl)propionate + NAD.; Cofactor: there is evidence that the E. coli enzyme may use FAD as a cofactor.; Function: the gene mhpA of E. coli has been identified with the 3-(3-hydroxyphenyl)propionate 2-hydroxylase activity.; Remark: E. coli is able to utilize aromatic acids as carbon and energy sources. A meta-cleavage pathway is used for the catabolism of 3-(3-hydroxyphenyl)propionate.; Title: similarity to 3-(3-hydroxyphenyl)propionate hydroxylase mhpA - Escherichia coli; See PMID 3531186; See PMID 6345502; See PMID 9098055
An05g02580	Function: trihydroxytoluene oxygenase of B. cepacia catalyzes the conversion of 2,4,5-trihydroxytoluene to 2,4-dihydroxy-5-methyl-6-oxy-2,4-hexadienoic acid in the 2,4-dinitrotoluene metabolism pathway.; Function: trihydroxytoluene oxygenase of B. cepacia is a meta-ring cleavage dioxygenase.; Title: strong similarity to trihydroxytoluene oxygenase dntD - Burkholderia cepacia; See PMID 8449889
An05g02590	Remark: the expression pattern of HIH-3 and its homology with HHDDI indicate that it plays a role in cancers (e. g., leukaemia, testicular cancer and melanomas) and immune disorders (e. g., asthma and atherosclerosis).; Similarity: the predicted ORF, as well as HIH-3 have chemical and structural homology with Methanococcus iannaschii 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDDI).; Title: strong similarity to isomerase homologue-3 HIH-3 from patent US5989860-A - Homo sapiens
An05g02600	Function: QUTA is a positively acting regulatory protein that regulates the expression of the eight genes comprising the quinic acid utilization gene (qut) gene cluster in A. nidulans.; Similarity: It has been proposed that the QUTA protein is composed of two domains that are related to the N-terminal two domains-dehydroquinate (DHQ) synthase and 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase-of the pentadomain AROM protein.; Similarity: the predicted ORF is shorter than A. nidulans QUTA; the presence of the fungal Zn(2)-Cys(6) binuclear cluster strongly suggests a role as transcription factor.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987
An05g02610	Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the ORF shows weak similarity to the putative transcriptional regulator FCR1 of C. albicans.; Similarity: the predicted ORF shows also similarity to several putative transcription factors.; Title: similarity to hypothetical protein EAA63118.1 - Aspergillus nidulans; See PMID 9864335
An05g02620	Similarity: shows similarity to proteins containing Fungal Zn(2)-Cys(6) binuclear cluster domains i. e. mainly transcriptional regulatory proteins.; Title: similarity to hypothetical transcriptional regulator FCR1 - Candida albicans; See PMID 9864335
An05g02630	Similarity: the weak similarity is due to a short,very well conserved stretch of amino acids.; Title: weak similarity to hypothetical phototropin AcNPH1 - Adiantum capillusveneris
An11g00010	Function: Mx proteins have antiviral activities.; Induction: Mx proteins are induced by interferon n response to double-stranded RNA.; Similarity: Mx proteins belong to a GTPase family that includes rat dynamin, Drosophila Shibire and the yeast proteins Vps1/Spo15 and Mgm1.; Similarity: similarity is between the N-terminal 3/4s of the predicted A. niger protein and O. mykiss Mx1,which is 200 aa shorter.; Title: similarity to antiviral GTPase Mx1 -Oncorhynchus mykiss; See PMID 7507812; See PMID 8528941
An11g00040	Title: weak similarity to cDNA for 59-kDa readthrough protein RT - Sorghum chlorotic spot virus; See PMID 10772992
An11g00050	Function: F. scirpi esyn1 is a multifunctional enzyme with N-methyltransferase and peptide synthetase activity required for N-Methylcyclopeptide antibiotica biosynthesis.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 8483420; See PMID 2205497
An11g00060	Function: M. grisea pth11p is a novel plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cues.; Localization: integral membrane protein.; Similarity: similarity is resticted to aminoterminal part of M. grisea pth11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An11g00070	Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: omtB of A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: shows no similarity at the aminoterminus of the A. parasiticus protein.; Similarity: shows similarity to several O-methyltransferases.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 8434913
An11g00080	Similarity: shows only partial similarity to M. grisea protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An11g00090	Similarity: the ORF encoded protein shows alsoweak similarity to the hypothetical protein B24M22. 80 from Neurospora crassa .; Title: similarity to hypothetical membrane protein pth - Blumeria graminis
An11g00100	Catalytic activity: triacylglycerol lipases catalyse triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Similarity: shows similarity to several carboxylesterase and lipases (EC 3. 1. 1. -).; Title: strong similarity to triacylglycerol lipase Lip5 - Candida rugosa
An11g00110	Function: levels of intracellular and extracellular cutinase activity increase in response to growth in the presence of cutin.; Function: the gene of M. grisea is expressed when cutin is the sole carbon source but not when the carbon source is cutin and glucose together or glucose alone.; Title: strong similarity to cutinase CUT1 -Magnaporthe grisea; See PMID 1557023
An11g00120	Similarity: shows similarity to several fungal sugar transporter.; Title: similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; See PMID 9335584
An11g00130	Function: a B. subtilis PNB carboxy-esterase (PNBCE) that catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: similarity to p-nitrobenzyl esterase pnbA -Bacillus subtilis
An11g00140	Similarity: shows only similarity to carboxyterminal part of the xlnR product.; Title: similarity to xylanolytic transcriptional activator xlnR - Aspergillus niger; See PMID 9758775
An11g00150	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein SC3A7. 19 from Streptomyces coelicolor and to putative the esterase estC of Burkholderia gladioli.; Title: similarity to hypothetical protein CAC04238.1 - Streptomyces coelicolor
An11g00170	Title: strong similarity to hypothetical protein encoded by An01g05460 - Aspergillus niger
An11g00180	Similarity: shows only short similarity at aminoterminus to carboxyterminus of enzyme of P. paucimobilis.; Title: weak similarity to lignostilbene alphabeta-dioxygenase I lsdB - Pseudomonas paucimobilis
An11g00190	Similarity: shows only partial similarity to several sugar and other transporter proteins.; Title: weak similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis
An11g00200	Function: it functions at low pH to liberate aroma-rich terpenes and aroma precursor compounds.; Function: the enzyme of C. Candida molischiana is a member of the family-3 glycosyl hydrolases.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245
An11g00210	Function: enzyme of B. sp. is a flavin dependent monooxygenase; contains FAD; requires NADPH.; Function: it is involved in the degradation of cyclohexanone.; Remark: putative sequencing error results in a premature STOP codon.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp. [putative sequencing error]; putative sequencing error; See PMID 10894733
An11g00220	Function: C. albicans CFL1 encodes a functional ferric reductase activity that can rescue a S. cerevisiae fre1 mutant.; Similarity: shows no similarity to ferric reductases at aminoterminus.; Title: similarity to ferric reductase cfl1 - Candida albicans; See PMID 10784045
An11g00230	Similarity: similarity is restricted to aminoterminus.; Similarity: to other oxygen oxidoreductases that covalently bind FAD.; Title: strong similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879
An11g00240	Function: a novel gene that is selectively induced both in roots and shoots of Z. mays in response to sulfur starvation.; Function: its glutathione-dependent regulation indicates that maize IRL may play a crucial role in the establishment of a thiol-independent response to oxidative stress under glutathione shortage conditions.; Similarity: similarity restricted to aminoterminus.; Title: weak similarity to 2-hydroxyisoflavone reductase IRL - Zea mays; See PMID 8597660
An11g00250	Function: lovF from A. terreus specifies formation of 2-methylbutyrate by acting as methyltransferase.; Remark: lovF is synonymous to lovastatin diketide synthase LDKS.; Similarity: similarity is confined to N-terminal half of predicted A. niger protein and lovF from A. terreus.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994
An11g00260	Function: in humans different MCT isoforms show specific import or export activity, depending on tissue type and substrate affinity.; Similarity: nine MCT-related sequences have so far been identified in mammals, each having a different tissue distribution, whereas six related proteins can be recognized in Caenorhabditis elegans and 4 in S. cerevisiae.; Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens; plasma membrane; See PMID 10510291
An11g00270	Function: in mammals sterol biosynthesis requires the removal of the 14 alpha-methyl group from lanosterol,this reaction is catalyzed by a microsomal cytochrome P450,the sterol 14 alpha-demethylase (P450(14DM) CYP51.; Title: strong similarity to lanosterol 14 alpha-demethylase CYP51 - Homo sapiens; See PMID 8619637
An11g00280	Function: in Aspergillus sp. the biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes including omtB.; Function: omtB of Aspergillus sp. catalyses the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361
An11g00290	Function: amyR from A. oryzae is a transcriptional activator involved in amylolytic gene expression.; Similarity: predicted A. niger protein contains a Zn(2)-Cys(6), fungal-type binuclear DNA-binding domain belonging to the GAL4 family of transcription factors.; Similarity: similarity to other proteins is confined to N-terminal region containing the Zn-finger domain.; Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498
An11g00300	Catalytic activity: salicylate 1-monooxygenase from P. putida uses NADH as the external reductant and catalyzes the conversion of salicylate to catechol by introduction of a hydroxyl group in concomitant with removal of a carboxyl group.; Function: salicylate 1-monooxygenase from P. putida is an external flavoprotein monooxygenase.; Title: strong similarity to salicylate 1-monooxygenase - Pseudomonas putida; See PMID 2916843
An11g00310	Function: C. albicans candidapepsin preferentially cleaves at the carboxyl of hydrophobic amino acids.; Title: similarity to aspartyl proteinase candidapepsin - Candida albicans; See PMID 2646602
An11g00320	Similarity: similarity of predicted A. niger protein is confined to C-terminal region of snbDE which is much (4400 aa) longer.; Similarity: the predicted A. niger protein shows similarity to a hypothetical protein, yukK from Bacillus subtilis, with similar length (400 aa).; Title: similarity to pristinamycin I synthase 3 SnbDE - Streptomyces pristinaespiralis; See PMID 9168598; See PMID 9303382
An11g00330	Similarity: the ORF shows weak similarity to avfA from A. flavus, which participates in the biosynthesis of aflatoxin.; Title: strong similarity to hypothetical protein encoded by An07g00480 - Aspergillus niger; See PMID 10806361
An11g00340	Remark: ORF judged questionable due to length below 100 aa and lack of similarities.; Title: questionable ORF
An11g00350	Function: BBE from P. somniferum catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine and represents the first committed step in the pathway leading to the antimicrobial alkaloid sanguinarine.; Title: strong similarity to berberine bridge enzyme BBE - Papaver somniferum; endosome; See PMID 8972604
An11g00360	Function: chimpanzee EDN is a host defense protein that is a member of the mammalian ribonuclease gene family.; Similarity: only N-terminal half of predicted A. niger protein shows similarity to chimpanzee EDN.; Title: weak similarity to eosinophil cationic protein ECP - Pan troglodytes; See PMID 7663519
An11g00370	Function: FacB from A. niger is a major regulatory gene involved in acetamide and acetate utilisation.; Remark: FacB is synonymous to AcuB.; Similarity: FacB from A. nidulans contains an N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, leucine zipper-like heptad repeat motifs and central and C-terminal acidic alpha-helical regions.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720
An11g00380	Function: in S. cerevisiae YAP1 transcriptionally regulated diazaborine resistance requires the efflux pump Flr1p, which is located in the cytoplasmic membrane.; Similarity: Flr1 from S. cerevisiae belongs to the major-facilitator-superfamily.; Similarity: the ORF shows similarity to several multi-drug resistance transporters (MDR).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10903515
An11g00390	Function: rhiE from E. chrysanthemi has rhamnogalacturonate lyase activity on rhamnogalacturonan I.; Remark: rhiE from E. chrysanthemi is secreted through the type II Out secretion pathway.; Title: similarity to rhamnogalacturonase rhiE -Erwinia chrysanthemi
An11g00400	Catalytic activity: human IVD catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.; Complex: human IVD is a homotetrameric, FAD-binding enzyme.; Function: human IVD catalyzes the third step in the catabolism of leucine.; Localization: human IVD is a nuclear-encoded,mitochondrial protein.; Remark: deficiency of human IVD leads to the clinical disorder isovaleric acidemia.; Similarity: the ORF shows similarity to several acyl-CoA dehydrogenases.; Title: similarity to isovaleryl-CoA dehydrogenase IVD - Homo sapiens; localisation:mitochondrion; See PMID 10713113
An11g00410	Similarity: similarity to SPAC15E1. 10 from S. pombe is between the C-terminal regions.; Similarity: the predicte A. niger protein shows unspecific similarity to glycine rich proteins.; Title: similarity to hypothetical protein SPAC15E1.10 - Schizosaccharomyces pombe
An11g00420	Function: PP2A appears to be the major kinase phosphatase in eukaryotic cells that downregulates activated protein kinases.; Function: protein phosphatase 2A is involved in hyphal growth of Neurospora crassa.; Title: strong similarity to serine/threonine specific phosphoprotein phosphatase type 2A catalytic chain PP2A - Neurospora crassa; cytoplasm; See PMID 9790584; See PMID 10322434
An11g00430	Function: human HGO cleaves the aromatic ring during the metabolic degradation of Phe and Tyr.; Function: mutations in human HGO lead to Alkaptonuria, a rare hereditary disorder of the phenylalanine catabolism.; Title: strong similarity to homogentisate 1,2-dioxygenase HGO - Homo sapiens; See PMID 9244427
An11g00440	Catalytic activity: lipases catalyse the reaction,Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Localization: In addition no extracellular lipase activity was detected with the lip2 knockout (KO) strain,strongly suggesting that extracellular lipase activity results only from expression of the LIP2 gene.; Localization: lip1 from Y. lipolytica is probably an intracellular or cell-bound lipase, because no clear signal sequence was identified.; Title: strong similarity to triacylglycerol lipase Lip1 - Yarrowia lipolytica; See PMID 10781549
An11g00450	Remark: the tetH gene is encoded on plasmid pVM111 of P. multocida.; Similarity: the ORF shows similarity to several amine transporters and tetracycline resistance proteins.; Title: strong similarity to tetracycline resistance protein tetH - Pasteurella multocida
An11g00460	Complex: human APP-BP1 binds to the amyloid precursor protein (APP) carboxyl-terminal domain and interacts with hUba3.; Function: Recent work suggests that human APP-BP1 participates in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8.; Function: expression of human APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and this function requires both hUba3 and hUbc12.; Function: human APP-BP1 together with hUba3 behaves like the ubiquitin activating enzyme E1, with hUba3 containing the active cysteine and ATP binding site.; Title: strong similarity to amyloid precursor protein-binding protein 1 APP-B1 - Homo sapiens; nucleus; See PMID 10722740; See PMID 11027288
An11g00470	Catalytic activity: RPIs catalyse the reaction,D-ribose 5-phosphate <=> D-ribulose 5-phosphate.; Function: RPI from M. musculus takes part in the pentose phosphate pathway.; Title: strong similarity to ribose 5-phosphate isomerase RPI - Mus musculus; cytoplasm; See PMID 7758956; See PMID 2843500
An11g00480	Function: sldA from A. nidulans take part in mitotic cycle control.; Title: strong similarity to spindle assembly checkpoint protein sldA - Aspergillus nidulans; nucleus; See PMID 9584089; See PMID 10723032
An11g00490	Function: S. pombe Fet5 heterospecific complementates a conditional mutant of S. cerevisiae defective in the function of the RNA polymerases I-III common subunit ABC10 beta.; Function: features of the S. pombe Fet5 amino acid sequence suggest that it belongs to ATP/GTP-binding proteins.; Title: similarity to purine nucleotide binding protein fet5p - Schizosaccharomyces pombe; See PMID 9190794
An11g00500	Complex: POP5 from S. cerevisiae is an integral subunit of RNase P and apparent subunit of RNase MRP.; Function: RNase MRP has been suggested to be involved in the processing of precursor rRNA; RNase P, in the maturation of tRNA.; Localization: RNase MRP/P have activity in both the nucleus and the mitochondria.; Remark: information concerning S. cerevisiae POP5 is drawn from http://genome-www4. stanford. edu/cgi-bin/SGD/locus. pl?locus=POP5 and as of 24/1/01/ not yet available in published form.; Similarity: FUN53 is synonymous to POP5.; Similarity: Processing Of Precursors - refer to a group of proteins that appear to be components of both RNase P and RNase MRP.; Title: strong similarity to Pop5 - Saccharomyces cerevisiae; nucleus; See PMID 8901493
An11g00510	Catalytic activity: ACLs catalyse the reaction, ATP + citrate + CoA <=> ADP + phosphate + acetyl-CoA + oxaloacetate.; Function: mutants of S. macrospora ACL1 exhibit a sterile phenotype with defects in fruiting body maturation.; Title: strong similarity to ATP citrate lyase ACL1 -Sordaria macrospora; cytoplasm; See PMID 9858569
An11g00530	Catalytic activity: ACLs catalyse the reaction, ATP + citrate + CoA <=> ADP + phosphate + acetyl-CoA + oxaloacetate.; Title: strong similarity to ATP citrate lyase - Homo sapiens; localisation:mitochondrion; See PMID 1371749
An11g00540	Title: weak similarity to hypothetical protein F18O22.300 - Arabidopsis thaliana
An11g00550	Complex: In the presence of ADP, one molecule of S. cerevisiae hsp10 binds to hsp60 with an apparent Kd of 0. 9 nM and a second molecule of hsp10 binds with a Kd of 24 nM.; Function: In the presence of ATP, the purified S. cerevisiae chaperonins mediate the refolding of mitochondrial malate dehydrogenase.; Function: S. cerevisiae hsp10 inhibits the ATPase activity of hsp60 by about 40%.; Title: strong similarity to chaperonin Hsp10 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9067800; See PMID 9256426
An11g00560	Complex: Coimmunoprecipitation experiments with S. cerevisiae proteins reveal that RNA14, a subunit of cleavage factor I (CF I), directly interacts with FIP1, but not with PAP1.; Complex: S. cerevisiae FIP1 interacts with poly(A) polymerase (PAP1) in the two-hybrid assay.; Function: Coimmunoprecipitation experiments with S. cerevisiae suggest a model in which Fip1 tethers PAP1 to CF I, thereby conferring specificity to poly(A) polymerase for pre-mRNA substrates.; Title: similarity to pre-mRNA polyadenylation factor Fip1 - Saccharomyces cerevisiae; nucleus; See PMID 7736590
An11g00570	Title: strong similarity to hypothetical xap-5-like protein - Schizosaccharomyces pombe
An11g00580	Similarity: human DKFZp564A0772. 1 is 80 aa shorter than the predicted A. niger protein. .; Title: similarity to hypothetical protein DKFZp564A0772.1 - Homo sapiens
An11g00590	Function: TmGRF from T. melitor belongs to the GCNF1 family and its in vitro translated product binds to the extended half site TCAAGGTCA with high affinity.; Similarity: similarity is from central part of predicted A. niger protein to N-terminus of TmGRF from T. melitor.; Title: weak similarity to nuclear hormone receptor TmGRF - Tenebrio molitor; See PMID 10518792
An11g00600	Catalytic activity: TauD from E. coli converts taurine to sulfite and aminoacetaldehyde.; Function: tauD of E. coli is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Remark: EC 1. 14. 11. 17 (not in EC number catalogue).; Remark: among the cosubstrates tested for E. coli TauD, only alpha-ketoglutarate (Km = 11 microM) supported significant dioxygenase activity.; Remark: taurine (Km = 55 microM) was the preferred substrate of E. coli TauD, but pentanesulfonic acid,3-(N-morpholino)propanesulfonic acid, and 1,3-dioxo-2-isoindolineethanesulfonic acid were also desulfonated at significant rates.; Similarity: tauD from E. coli is a member of the alpha-ketoglutarate-dependent dioxygenase family.; Title: strong similarity to taurine dioxygenase tauD - Escherichia coli; See PMID 9287300
An11g00610	Similarity: S. cerevisiea NUP49 belongs to the GLGF family of nucleoporins.; Title: strong similarity to nuclear pore complex subunit Nup49 - Saccharomyces cerevisiae; nucleus; See PMID 10684247
An11g00620	Title: similarity to guanine nucleotide-binding protein beta 5 Gnb5 - Mesocricetus auratus; See PMID 7613025
An11g00630	Function: in D. discoideum DhkA functions both in the regulation of prestalk gene expression and in the control of the terminal differentiation of prespore cells.; Function: in D. discoideum SDF-2 peptide, released by prestalk cells during culmination, stimulates prespore cells to encapsulate by binding to the DhkA transmembrane receptor.; Pathway: in D. discoideum suppressor studies indicate that the cyclic AMP (cAMP) phosphodiesterase RegA and the cAMP-dependent protein kinase PKA act downstream of DhkA.; Remark: central part of predicted A. niger protein shows putatively unspecific similarity to asparagine rich proteins.; Remark: similarity of predicted A. niger protein to DhkA of D. discoideum is not restricted to asparagine repeats.; Title: similarity to sensory transduction histidine kinase dhkA - Dictyostelium discoideum; plasma membrane; See PMID 8670894; See PMID 9191038; See PMID 10373524
An11g00640	Catalytic activity: L. lactis pgmB catalyses the conversion of beta-glucose 1-phosphate to glucose 6-phosphate.; Similarity: the ORF shows similarity to haloacid dehalogenase-like hydrolases from several species (GS1-like proteins of the CBBY/CBBZ/GPH/YIEH family).; Title: similarity to phosphoglucomutase pgmB -Lactococcus lactis; See PMID 9084169
An11g00650	Remark: human tpr1 interacts in a two-hybrid screen with the GAP-related domain of neurofibromin, the product of the NF1 gene.; Title: strong similarity to tetratricopeptide repeat protein tpr1 - Homo sapiens; See PMID 8836031
An11g00660	Catalytic activity: B. subtilis pnbA catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Similarity: the ORF shows additionally strong similarity to several triacylglycerol lipases from different species.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An11g00670	Function: in human cell culture cathepsin D was identified as the first endosomal ceramide target that colocalizes with and may mediate downstream signaling effects of A-SMase.; Function: murine ASM is reported to have an essential function in stress-induced apoptosis and in CD95-induced apoptosis.; Remark: murine ASM is a lysosomal glycoprotein.; Title: strong similarity to acidic sphingomyelin phosphodiesterase ASM - Mus musculus; lysosome; See PMID 8943261; See PMID 10508159; See PMID 10867001; See PMID 11001565
An11g00680	Catalytic activity: SGTs can use different sterols such as cholesterol, sitosterol, and ergosterol as sugar acceptors.; Function: Microorganisms containing a recombinant SGT protein have better resistance to high salt/ethanol content of growth media, cold/frost and high temperature.; Function: Sterol glucosides, typical membrane-bound lipids, are biosynthesized by a UDP-glucose:sterol glucosyltransferase.; Remark: literature for SGT from A. sativa is Patent WO9817789.; Similarity: no similarity to C-terminal 300 aa of predicted A. niger protein was found.; Title: similarity to sterol glycosyltransferase SGT - Avena sativa; See PMID 10224056
An11g00690	Similarity: N-terminus of predicted A. niger protein shows similarity to viral anti-apoptotic peptides.; Similarity: only N- and C-terminal 100 aa of predicted A. niger protein show similarity to N- and C-terminus of S. cerevisiae YNL008c.; Title: similarity to hypothetical ubiquitin protein ligase Asi3 - Saccharomyces cerevisiae
An11g00700	Similarity: predicted A. niger protein shows unspecific similarity to serine rich proteins.; Title: weak similarity to mucin PGM-B - Sus scrofa; See PMID 7755593
An11g00710	Title: strong similarity to immunoreactive Antigen 2 Ag2 - Coccidioides immitis; plasma membrane; See PMID 8973319
An11g00720	Complex: in S. pombe the pol delta complex consists of five subunits.; Title: similarity to DNA-directed DNA polymerase delta chain cdm1p - Schizosaccharomyces pombe; See PMID 9326594
An11g00730	Similarity: hypothetical protein contains domains with similarity to cGMP-gated ion channel proteins.
An11g00740	Similarity: SPBC19G7. 08c of S. pombe is N-terminally approx. 100 amino acids longer.; Title: similarity to hypothetical protein SPBC19G7.08c - Schizosaccharomyces pombe
An11g00742	Function: In over-expression of cdm1 is able to rescue cells carrying temperature-sensitive mutations in either pol3+/cdc6+, cdc1+ or cdc27+.; Function: S. pombe cCells deleted for cdm1+ are viable.; Function: cdm1 from S. pombe encodes the smallest (22kDa) subunit of the DNA polymerase delta complex.; Title: similarity to DNA-directed DNA polymerase delta chain cdm1p - Schizosaccharomyces pombe; nucleus; See PMID 9799358
An11g00744	Remark: Ag2 from C. immitis encodes an immunoreactive protein.; Remark: Ag2 from C. immitis is a glycosylated protein present in the cell walls.; Title: similarity to immunoreactive protein precursor Ag2 - Coccidioides immitis; cell wall; See PMID 8561782; See PMID 8973319
An11g00748	Remark: the ORF is N-terminally truncated due to border of contig.; Remark: the similarities to the different ubiquitin-protein ligases is restricted to the very C-terminus.; Remark: ubiquitin-protein ligases of the class III only share C-terminal sequence similarities.; Title: weak similarity to ubiquitin protein ligase Asi3 - Saccharomyces cerevisiae [truncated ORF]
An11g00750	Catalytic activity: endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.; Complex: heterotetramer composed of SEN2, SEN15,SEN34 and SEN54.; Complex: this subunit interacts with SEN2.; Function: SEN54 of S. cerevisiae cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.; Function: SEN54 of S. cerevisiae encodes one of the catalytic subunits of the tRNA-splicing endonuclease which is responsible for identification and cleavage of the splice sites in pre-tRNA.; Remark: YPL083c is synonymous to SEN54.; Remark: there are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.; Title: similarity to tRNA-splicing endonuclease subunit Sen54 - Saccharomyces cerevisiae; See PMID 9200603
An11g00760	Pathway: fabG of B. subtilis is involved in phospholipid synthesis.; Remark: fabG of B. subtilis exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates.; Similarity: closest manual homologue (BLASTP): PIRNEW:T46633 3-oxoacyl-[acyl-carrier-protein] reductase fabG - Bacillus subtilis.; Similarity: data bank entries are N- and C-terminally shorter than this protein.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840
An11g00770	Function: in vitro, recombinant SAE1/SAE2 (SUMO-1-activating enzyme) catalyzes the ATP-dependent formation of a thioester linkage between SUMO-1 and SAE2.; Remark: SUMO-1 is a small ubiquitin-related modifier that is covalently linked to many cellular protein targets.; Remark: modification by SUMO-1 is proposed to play a role in protein targeting and/or stability.; Title: strong similarity to SUMO-1 activating enzyme subunit 2 SAE2 - Homo sapiens; See PMID 10187858
An11g00780	Remark: based on the hypothetical protein B2A19. 160 an additional intron could be introduced.; Title: strong similarity to hypothetical protein B2A19.160 - Neurospora crassa
An11g00790	Similarity: a similarity exists only at the N-terminal sequence.; Title: strong similarity to hypothetical protein EAA64158.1 - Aspergillus nidulans
An11g00800	Catalytic activity: cyp-4 of C. elegans catalyzed the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: cyp-4 of C. elegans catalyses one step in the refolding of urea-denatured ribonuclease A. The enzyme is identical with the protein which binds the immunosuppressive drug cyclosporin; Remark: cyp-4 of C. elegans is a cis-trans-Isomerase.; Similarity: cyp-4 of C. elegans belongs to the cyclophilin-type PPIase family.; Title: similarity to peptidyl-prolyl cis-trans isomerase 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762; See PMID 10228556; See PMID 10424896
An11g00810	Function: PUT3 of S. cerevisiae binds to DNA sequences in the promoters of the proline utilization genes and is required for the basal and induced expression of the enzymes of this pathway.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; See PMID 2017167
An11g00830	Title: similarity to hypothetical protein B2O8.180 -Neurospora crassa
An11g00840	Catalytic activity: DBR1 hydrolyzes the 2'-5' phosphodiester linkage at the branchpoint of excised intron lariats.; Function: DBR1 is a debranching enzyme with a RNA processing activity that cleaves the branchpoint of excised intron lariats.; Remark: based on sequence similarities an unusually large intron was introduced in this ORF during the gene modelling process.; Remark: none of the gene modelling programs predicted an intron at this position, therefore the occurence of this big intron might be questionable.; Title: strong similarity to RNA lariat debranching enzyme hDBR1 - Homo sapiens; See PMID 10982890
An11g00850	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g00860	Complex: rat TIP120 binds to TATA-binding protein (TBP) and to RPB5, one of the common subunits of the eukaryotic RNA polymerases.; Function: rat TIP120 activates the basal level of transcription from various kinds of promoters and also stimulates RNAP I- and III-driven transcription.; Function: rat TIP120 functions during preinitiation complex (PIC) formation at the step of RNAP II/TFIIF recruitment to the promoter.; Function: rat TIP120 interacts with TBP wich is a central component for transcriptional regulation.; Localization: rat TIP120 was isolated from nuclear extracts.; Title: strong similarity to TATA-Binding protein-interacting protein TIP120 - Rattus norvegicus; nucleus; See PMID 10567521
An11g00870	Remark: the similarity to CAD21060. 1 from N. crassa is restricted to the N-terminal half.; Remark: the similarity to other proteins is mainly based on repetetive structures.; Title: similarity to hypothetical protein CAD21060.1 - Neurospora crassa
An11g00880	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g00900	Similarity: Remark: blastp shows significant similarity (42% identity) between predicted A. niger protein and R. prowazekii addA but due to shortness of both peptides the probability is low (p=4,4).; Title: similarity to hypothetical erythrocyte adducin alpha chain addA - Rickettsia prowazekii
An11g00910	Function: Deletion analysis demonstrated that a 412-residue N-terminal domain, which includes an acidic region and the TBP-binding domain, is required for R. norvegicus TIP120 function.; Function: R. norvegicus TIP120 activates the basal level of transcription from various kinds of promoters regardless of the template DNA topology and the presence of TFIIE/TFIIH and TBP-associated factors.; Function: R. norvegicus TIP120 also stimulates RNAP I- and III-driven transcription.; Similarity: similarity is from predicted A. niger protein to N-terminus of R. norvegicus TIP120, which is 900 aa longer.; Title: similarity to TATA-Binding protein-interacting protein TIP120 - Rattus norvegicus; nucleus; See PMID 10567521; See PMID 8954946
An11g00920	Function: Pneumococci in which pgdA was inactivated produced fully N-acetylated glycan and became hypersensitive to exogenous lysozyme in the stationary phase of growth.; Title: similarity to peptidoglycan GlcNAc deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617
An11g00930	Title: similarity to hypothetical protein EAA64167.1 - Aspergillus nidulans
An11g00940	Complex: S. cerevisiae Pep3p and Pep5p associate physically with Pep7p as revealed by two-hybrid analysis.; Function: S. cerevisiae PEP5 is required for vacuole biogenesis and maintenance of the vacuole structure itself, for gluconeogenic growth and mating response in S. cerevisiae.; Function: in S. cerevisiae a core Pep3p/Pep5p complex putatively promotes vesicular docking/fusion reactions in conjunction with SNARE proteins at multiple steps in transport routes to the vacuole and might be responsible for tethering transport vesicles on target membranes.; Remark: alternative names for S. cerevisiae PEP5 are END1, VAM1, VPL9, VPS11, VPT11 and YMR231W.; Title: strong similarity to vacuolar biogenesis protein Pep5 - Saccharomyces cerevisiae; vacuole; See PMID 10978279; See PMID 2670552; See PMID 2676511
An11g00950	Function: N. tabacum PK12 phosphorylates and physically interacts with serine/arginine-rich (SR) splicing factors in vivo to alter their activity and the splicing of target mRNAs.; Induction: tobacco PK12 is induced by the plant hormone ethylene.; Similarity: N. tabacum PK12 is a member of the LAMMER family of protein kinases.; Title: similarity to protein kinase PK12 - Nicotiana tabacum; deleted EC_number 2.7.1.37; See PMID 8989879; See PMID 10652154
An11g00960	Title: similarity to hypothetical protein encoded by An08g08360 - Aspergillus niger
An11g00970	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: blastp hits of predicted A. niger protein are likely caused by repetetive sequence motives.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886
An11g00980	Remark: blastp hits are caused by repetetive sequence motives.
An11g00990	Function: in S. cerevisiae Lag1p and Dgt1p redundantely facilitate efficient ER-to-Golgi transport of GPI-anchored proteins.; Remark: deletion of LAG1 increases lifespan by 50% in S. cerevisiae.; Title: strong similarity to ER-to-Golgi transporter Lag1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10198056; See PMID 8195187; See PMID 8810036
An11g01000	Function: a two component regulatory system consisting of GacS (sensor kinase) and GacA (transcriptional response regulator) is responsible for regulation of secondary metabolism in P. fluorescens.; Remark: alternative names for P. fluorescens GacS are ApdA and LemA.; Title: similarity to sensor kinase GacS -Pseudomonas fluorescens; plasma membrane; See PMID 10919762
An11g01020	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g01040	Localization: OPT1 of C. albicans is probably located in the plasma membrane.; Similarity: C. albicans OPT1 is not a member of the ABC or PTR membrane transport families.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116
An11g01050	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g01060	Function: C. lindemuthianum CLTA1 is a regulatory pathogenicity gene involved in the switch between biotrophy and necrotrophy of the infection process.; Similarity: C. lindemuthianum CLTA1 and the predicted A. niger protein contain a Gal4-type fungal zinc cluster (Zn[II](2)Cys(6)) DNA-binding domain.; Title: strong similarity to transcription activator CLTA1 - Colletotrichum lindemuthianum; nucleus; See PMID 11006333
An11g01070	Catalytic activity: guanine deaminases catalyse the reaction, guanine + H2O = xanthine + NH3.; Function: human nedasin associates with the MAGUK family protein NE-dlg/SAP102, and interferes with the association between NE-dlg/SAP102 and NMDA receptor 2B in vitro.; Title: strong similarity to guanine deaminase p51-nedasin - Homo sapiens; cytoplasm; See PMID 10542258
An11g01080	Title: strong similarity to hypothetical protein CAF06066.1 - Neurospora crassa
An11g01090	Remark: blastp hits are caused by repetetive sequence motives.
An11g01100	Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis [truncated ORF]; plasma membrane; See PMID 8830679
An11g01110	Remark: the predicted intron/exon structure might not be correct (introns missing).; Similarity: the human protein is similar to prokaryotic pepstatin insensitive carboxyl proteases, its deficiency is causing a fatal neurodegenerative disease.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens
An11g01120	Similarity: shows similarity to several dehydrogenases of different specificities.; Title: strong similarity to NADPH-dependent aldehyde reductase - Sporobolomyces salmonicolor; See PMID 8779568; See PMID 1633196
An11g01140	Similarity: the ORF encoded protein shows also weak similarity to GTP-binding protein VC0763 from Vibrio cholerae.; Title: weak similarity to hypothetical protein encoded by An16g00260 - Aspergillus niger
An11g01150	Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Similarity: shows similarity to several cytochrome P450 homologs.; Title: similarity to hypothetical cytochrome P450 monooxygenase p450-4 - Gibberella fujikuroi; See PMID 9917370
An11g01160	Function: chitinases catalyze the hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymeres of chitin.; Remark: The deduced protein is much shorter than similar proteins from data banks and shows only similarity to the C-terminal half of chitinases. .; Title: similarity to chitinase Chi1 - Aphanocladium album; See PMID 1735126
An11g01170	Title: questionable ORF
An11g01180	Title: weak similarity to immunoglobulin kappa light chain - Mus musculus
An11g01190	Title: similarity to protein participating in extracellular/cell surface phenomena Ecm33 - Saccharomyces cerevisiae; See PMID 9335584; See PMID 10734606
An11g01200	Similarity: the ORF also shows strong similarity to the EST an_1007 from Aspergillus niger.; Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein arcA from Aspergillus nidulans.; Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa
An11g01210	Title: weak similarity to hypothetical protein MTH201 - Methanobacterium thermoautotrophicum
An11g01220	Function: tannase hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An11g01230	Title: weak similarity to envelope protein - Spleen focusforming virus
An11g01240	Function: Dfg5p of S. cerevisiae is required for filamentous growth, cell polarity, and cellular elongation.; Title: similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077
An11g01250	Similarity: shows some similarity to several cyclin-dependent kinases.; Title: weak similarity to cyclin-dependent kinase Cdk8 - Drosophila melanogaster; See PMID 8730095
An11g01260	Similarity: only partial similarity to magnesium/cobalt transport protein sll0671 of Synechocystis, but belongs also to COG0598 and might thus be a metal ion transporter.; Title: weak similarity to hypothetical protein encoded by B1D4.080 - Neurospora crassa
An11g01270	Similarity: shows similarity to several putative and known amino-acid transporter proteins.; Title: similarity to amino acid permease Mmp1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10497160
An11g01280	Title: weak similarity to hypothetical protein jhp1206 - Helicobacter pylori
An11g01300	Function: due to SGD RSA2 is involved in ribosome assembly.; Remark: the systematic genename of RSA2 is YMR131c.; Title: strong similarity to protein involved in ribosome assembly Rsa2 - Saccharomyces cerevisiae
An11g01310	Similarity: shows strong similarity to several small GTP-binding proteins of the ras superfamily with different specificities.; Title: strong similarity to septum-promoting GTPase spg1p - Schizosaccharomyces pombe; See PMID 9203579
An11g01330	Title: similarity to hypothetical protein encoded by SMc00431 - Sinorhizobium meliloti
An11g01340	Function: In Neurospora the expression of a set of unlinked structural genes, which allows utilization of various nitrogen-containing compounds, is controlled by the positive-acting nit-2 gene and the negative-acting nmr gene.; Similarity: The deduced polypeptide is too short (N-term 50 AA; C-term 100 AA) compared to the proteins from data bases.; Title: similarity to nitrogen metabolic regulation protein NMR - Neurospora crassa; See PMID 2146484
An11g01350	Function: the plant protein kinase phosphorylates serine, threonine, and tyrosine.; Remark: the deduced protein is C-terminal approx. 100 AA shorter than the blastp hits.; Similarity: shows also similarity to casein kinase I epsilon CKIe - Xenopus laevis (PUBMED 10517632).; Title: similarity to protein kinase ADK1 -Arabidopsis thaliana; See PMID 7527390
An11g01360	Similarity: Similarity to several proteins is based on repetetive sequence.
An11g01370	Similarity: similarities to several proteins are based on a 'D-rich' region.
An11g01390	Function: the bacterial enzyme catalyzes the oxidation of D-3-phosphoglycerate to 3-phosphohydroxypyruvate. It is the first committed step in the 'phosphorylated' pathway of serine biosynthesis.; Similarity: shows also similarity to glycerate dehydrogenase hprA - Pseudomonas aeruginosa (EC: 1. 1. 1. 29).; Title: similarity to phosphoglycerate dehydrogenase serA - Bacillus subtilis; See PMID 7934829
An11g01400	Title: similarity to hypothetical protein CAB92029.2 - Neurospora crassa
An11g01410	Function: members of the ATZ/TRZ family catalyse hydrolytic dechlorination of their substrates.; Remark: The bacterial enzyme catalyzes the dechlorination of atrazine to hydroxyatrazine via a hydrolytic reaction.; Title: similarity to atrazine chlorohydrolase atzA -Pseudomonas sp.; See PMID 8759853
An11g01420	Similarity: N-terminal half shows some similarity to N-terminal half of several yeast transcription factors.; Title: weak similarity to transcription activator Cad1 - Saccharomyces cerevisiae
An11g01430	Title: strong similarity to hypothetical protein CAC18266.1 - Neurospora crassa
An11g01480	Title: weak similarity to hypothetical RNA polymerase - Pelargonium leaf curl virus
An11g01490	Similarity: shows similarity to the C-terminal half of the phage protein.; Title: weak similarity to protein 40A - Phage phi80
An11g01510	Title: weak similarity to the protein involved in sister chromatid segregation Src1 - Saccharomyces cerevisiae
An11g01520	Catalytic activity: adenylate cyclases catalyze the conversion of ATP = 3',5'-Cyclic AMP + Pyrophosphate; Function: adenylate cyclases play essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, cAMP.; Title: strong similarity to adenylate cyclase MAC1 -Magnaporthe grisea; See PMID 9707535
An11g01530	Title: questionable ORF
An11g01540	Function: members of this family of putative glycosidases (CRH1, CRH2, and CRR1) might exert a common role in cell wall organization at different stages of the yeast life cycle.; Localization: CRH1 of S. cerevisiae is localized at the cell surface, particularly in chitin-rich areas.; Remark: the systematic genename of CRH1 of S. cerevisiae is YGR189C.; Similarity: shows also similarities to several endo-glucanases.; Similarity: strong similarity to allergen rAsp f 9 of Aspergillus fumigatus.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; cell wall; See PMID 10757808
An11g01550	Function: The C. maltosa enzyme catalyzes the hydroxylation of n-hexadecane and lauric acid.; Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Title: strong similarity to cytochrome P450 52A4 -Candida maltosa; See PMID 9501474; See PMID 9717384
An11g01560	Similarity: shows minor similarity to central part of probable PPE protein (G70570) of M. tuberculosis.
An11g01570	Function: Nab2p of S. cerevisiae is an essential protein binding to polyadenylated RNA and single-stranded DNA.; Remark: Nab2p of S. cerevisiae is believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.; Remark: Nab2p of S. cerevisiae may be involved not only in RNA processing but also in transcription regulation.; Similarity: the similarity of this ORF to Nab2p of S. cerevisisae can be discussed, since there are a number of gaps and only few stretches showing significant similarity, thus we do not consider to make a functional prediction on this ORF.; Title: similarity to nuclear polyadenylated RNA-binding protein Nab2 - Saccharomyces cerevisiae; See PMID 8474438
An11g01580	Catalytic activity: protoporphyrinogen oxidase catalyzes the conversion of protoporphyrinogen IX + O2 = Protoporphyrin IX + H2O.; Pathway: porphyrin metabolism.; Title: similarity to protoporphyrinogen oxidase PPO - Mus musculus; See PMID 8554330
An11g01600	Title: similarity to polypeptide SEQ ID NO:21825 from patent WO200171042-A2 - Drosophila melanogaster
An11g01610	Catalytic activity: ubiquitin-protein ligases catalyze the conversion of ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate + Protein N-ubiquityllysine.; Remark: in most cases ubiquitinated proteins will be degraded.; Remark: the systematic gene name of UBR1 is YGR184C.; Title: similarity to ubiquitin protein ligase Ubr1 -Saccharomyces cerevisiae
An11g01630	Function: nmt2 of S. pombe is involved in the biosynthesis of the thiamine precursor thiazole.; Induction: nmt2 of S. pombe is repressed by thiazole.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the thi4 family.; Similarity: strong similarity to stress-inducible protein sti35 - Fusarium oxysporum; Title: strong similarity to thiazole biosynthesis protein nmt2p - Schizosaccharomyces pombe; See PMID 7992507; See PMID 9606189
An11g01640	Catalytic activity: phospholipase C catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; EC:3.1.4.11; Function: phospholipase C type enzymes hydrolyze inositolphosphosphingolipids (IPC, MIPC, M(IP)2C) as well as sphingomyelin.; Phenotype: the ISC2 null mutant of S. cerevisisae is viable and contains more inositolphosphosphingolipids.; Remark: the systematic name of ISC2 is YER019w.; Similarity: shows also similarity to probable lipid metabolism protein with similarity to sphingomyelinase family of S. pombe.; Title: similarity to phospholipase C type Isc2 -Saccharomyces cerevisiae; See PMID 11006294
An11g01650	Similarity: shows similarity only to the WD-repeat domains of these proteins.; Similarity: shows similarity to several WD-repeat proteins of different organisms.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 10322433
An11g01660	Title: similarity to hypothetical protein B24P11.210 - Neurospora crassa
An11g01670	Title: weak similarity to brain development related protein LjOtxA - Lampetra japonica
An11g01690	Remark: belongs to the S30E family of ribosomal proteins.; Remark: there are two genes for S30 in S. cerevisiae (RPS30B;YOR182c and RPS30A;YLR287c-a).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S30 - Saccharomyces cerevisiae; cytoplasm
An11g01700	Function: RTG2 of S. cerevisiae is a pivotal gene in controlling interorganelle communication between mitochondria, peroxisomes, and the nucleus in the context of retrograde regulation.; Function: RTG2 of S. cerevisiae is required, in particular, for the retrograde expression of the peroxisomal isoform of citrate synthase, cit2.; Function: the expression of some nuclear genes is sensitive to the functional state of mitochondria, a process termed retrograde regulation.; Phenotype: S. cerevisiae cells bearing a RTG2 null mutation are viable and respiratory competent; however,they are auxotrophic for glutamic or aspartic acid and cannot use acetate as a sole carbon source, suggesting that both the tricarboxylic acid and glyoxylate cycles are compromised.; Similarity: RTG2 of S. cerevisiae contains an N-terminal ATP binding domain similar to that found in hsp70 homologues, and shares some sequence similarity with phosphatases.; Title: strong similarity to regulator protein Rtg2 -Saccharomyces cerevisiae; cytoplasm; See PMID 7629125; See PMID 8422683; See PMID 10848632
An11g01710	Title: weak similarity to ATP:scyllo-inosamine phosphatransferase stsE - Streptomyces griseus; See PMID 9238101
An11g01720	Function: TNA1 of S. cerevisiae is necessary for nicotinic acid import into the cell.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: TNA1 of S. cerevisiae is a members of the yeast Dal5p (allantoate/ureidosuccinate permease) subfamily of the major facilitator family of tranmembrane transporters.; Similarity: the Dal family proteins are weakly similar to bacterial (hypothetical) permeases for tartrate (ttuB), 4-hydroxyphenylacetate (hpaX), phtalate (Pht1),suggesting that proteins of the Dal family correspond to permeases for carboxylic acids.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An11g01740	Similarity: the similarity to SPBP23A10. 05 of S. pombe is limited to the N-terminus of the predicted ORF.; Title: similarity to hypothetical coiled-coil protein SPBP23A10.05 - Schizosaccharomyces pombe
An11g01750	Similarity: stretches of repetitive elements at the N- and C-termini show weak similarity with the circumsporozoite protein of Plasmodium vivax.; Similarity: the similarity with YGR086c of S. cerevisiae is strong in the central part of the molecule.; Title: similarity to hypothetical protein YGR086c -Saccharomyces cerevisiae
An11g01760	Catalytic activity: PRE2 has a chymotrypsin-like proteolytic activity.; Complex: the 20 S proteasome is a cylindrical particle with two outer rings each made of 7 different alpha-type subunits and two inner rings made of 7 different beta-type subunits. S. cerevisiae Pre2p is the beta 5 subunit.; Complex: the 20S proteasome from the yeast S. cerevisiae is composed by 28 protein subunits, and constitutes the proteolytic core of the larger 26S proteasome complex.; Function: the 26 S proteasome is the central protease involved in ubiquitin-mediated protein degradation and fulfills vital regulatory functions in eukaryotes.; Localization: proteasomes are mainly localised in the in the nuclear envelope-ER network.; Remark: PRE2 of S. cerevisiae is also called DOA3,PRG1,or SRR2.; Remark: PRE2 of S. cerevisiae is synthesized as precursor and is processed in a manner apparently identical to that of related mammalian proteasome subunits implicated in antigen presentation.; Similarity: PRE2 of S. cerevisiae is a beta-type member of the proteasomal gene family.; Similarity: part of the predicted ORF is identical to A. niger EST EMBLEST Acc. BE758781; gaps in the BLASTP alignments were not corrected by gene modeling due to the experimentally derived mRNA evidence.; Similarity: the PRE2 protein of S. cerevisiae shows striking homology to the human Ring10 protein, which is encoded in the major histocompatibility complex class II region and have sequence homology to proteasome-encoding genes.; Title: strong similarity to proteasome 20S subunit Pre2 - Saccharomyces cerevisiae; See PMID 7781614; See PMID 8383129; See PMID 9087403; See PMID 9312134
An11g01770	Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Complex: RNA polymerase I consists of 14 different subunits; this subunit is the second largest component of RNA polymerase I.; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase I is essentially used to transcribe ribosomal DNA units.; Phenotype: N. crassa strain un-18, producing a temperature-sensitive mutant of the RNA polymerase I 135K subunit, shows alterations of the period of the circadian conidiation rhythm.; Similarity: belongs to the RNA polymerase beta chain family.; Similarity: very strong similarity to RNA polymerase I subunit of different species.; Title: strong similarity to 135 kD subunit of DNA-directed RNA polymerase I - Neurospora crassa; nucleus; See PMID 9749669; See PMID 1990281
An11g01790	Function: ADP-ribosylation factors (ARF) are 20 Kd GTP-binding proteins involved in protein trafficking, which may modulate vesicle budding and uncoating within the Golgi apparatus.; Function: ARF1 of T. gondii can augment release of constitutively secreted vesicles at the target membrane.; Function: ARFs also act as allosteric activators of cholera toxin ADP-ribosyltransferase activity.; Golgi; Localization: ARF1 of T. gondii is located in the Golgi/TGN.; Similarity: the protein shows strong similarity to many ADP-ribosylation factor-like proteins of different plant and animal species.; Title: strong similarity to ADP ribosylation factor 1 ARF1 - Toxoplasma gondii; See PMID 11208125; See PMID 11210540; See PMID 11278405
An11g01800	Title: questionable ORF
An11g01810	Similarity: due to the polyglutamine and polyproline stretches, the protein shows weak similarities with polyglutamine-containing proteins (like huntingtin), or polyprolin-containing proteins (like extensins).; Title: weak similarity to hypothetical membrane protein YBR005w - Saccharomyces cerevisiae
An11g01830	Similarity: the protein shows similarity to extensins of several species due to the high proline content.; Title: similarity to hypothetical fibroin-3 related protein B14D6.620 - Neurospora crassa
An11g01840	Title: strong similarity to hypothetical protein SPAC1F3.09 - Schizosaccharomyces pombe
An11g01850	Remark: a putative sequencing error results in an frameshift.; Similarity: the protein shows strong similarity to the DRIM protein of Homo sapiens, a gene with unknown function, which is downregulated in tumor metastasis.; Title: strong similarity to hypothetical protein SPBC56F2.04 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; See PMID 9673349
An11g01860	Remark: SPAC24H6. 02c in S. pombe is contiguous to the cullin 3 homolog on chromosome 1.; Title: strong similarity to hypothetical protein SPAC24H6.02c - Schizosaccharomyces pombe
An11g01870	Function: Cul3 of M. musculus and H. sapiens is important for the ubiquitination and degradation of free cyclin E (i. e. not bound to Cdk2).; Function: cyclin E controls the G1/S phase transition.; Localization: Cul3 of M. musculus and H. sapiens is located both in the nucleus and in the Golgi apparatus; the Golgi localization suggests that Cul3 might have additional substrates.; Phenotype: homozygous deletion of the Cul3 gene in mouse causes an embryonic lethal phenotype due to abnormal regulation of S phase in extraembrioniyc ectodermal and trophoblastic cells.; Similarity: Cul3 belongs to the cullin family of E3 ubiquitin-protein ligases; it was demonstrated that it exherts very similar functions in man and mouse; Title: strong similarity to cullin 3 Cul3 - Mus musculus; nucleus; See PMID 10500095
An11g01880	Title: similarity to hypothetical protein YDR489w -Saccharomyces cerevisiae
An11g01890	Catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; Function: dephosphorylates O-phosphotyrosine groups in phosphoproteins.; Function: nimT of A. nidulans is required for mitosis.; Function: nimT of A. nidulans is required for tyrosine dephosphorylation of p34cdc2 and has a strong homology to cdc25-type proteins.; Title: strong similarity to tyrosine phosphatase nimT - Aspergillus nidulans; See PMID 1534750; See PMID 6352675
An11g01910	Remark: partial similarities to different database entries.
An11g01930	Function: ankyrins attach integral membrane proteins to cytoskeletal elements.; Localization: ank1 of H. sapiens binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein gp85, and to skeletal proteins fodrin, tubulin, vimentin and desmin.; Remark: several splice forms of the human ank1 are known.; Similarity: similarity is restricted to the N-terminal part of ank1.; Title: similarity to ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 11018513
An11g01940	Remark: protein shows partial similarities to different protein kinase motifs.; Title: weak similarity to hypothetical protein encoded by An01g12000 - Aspergillus niger
An11g01950	Title: strong similarity to DNA polymerase V Pol5 -Saccharomyces cerevisiae; nucleus; See PMID 7667891; See PMID 8953036
An11g01960	Catalytic activity: transulphurylation reaction.; Function: hxB of A. nidulans is necessary for the post-translational activation of purine hydroxylases (molybdenum-containing enzymes of the hydroxylase class) by attaching a terminal sulfur atom to the molybdenum cofactor.; Function: the molybdopterin cofactor is required for the activity of a variety of oxidoreductases.; Remark: truncated ORF due to the contig end.; Title: similarity to transsulphurylation protein hxB - Aspergillus nidulans [truncated ORF]; See PMID 10096075; See PMID 11029694
An11g01970	Function: PGPI of P. furiosus releases an N-terminal pyroglutamyl group from a polypeptide, provided the next residue is not proline.; Remark: PGPI is inhibited by thiol-blocking reagents.; Similarity: PGPI belongs to peptidase family C15.; Title: similarity to pyroglutamyl-peptidase I PGPI -Pyrococcus furiosus; See PMID 10552639; See PMID 9920379
An11g01980	Function: this P450 of G. fujikuroi is, together with three similar P450 monooxygenases, a putative geranylgeranyl diphosphate synthase, and a copalyl diphosphate synthase, involved in gibberellin biosynthesis.; Title: strong similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 10531641; See PMID 9917370
An11g01990	Remark: blast hits based on repetitive sequence.
An11g02000	Function: sldA of E. nidulans plays a role in mitosis.; Remark: mutations in sldA and sldB of E. nidulans confer hypersensitivity to the microtubule-destabilizing drug benomyl.; Remark: mutations in sldA and sldB show a strong synthetic lethal interaction with a mutation in the mitotic kinesin bimC.; Title: strong similarity to spindle assembly checkpoint protein sldA - Aspergillus nidulans; See PMID 9584089
An11g02010	Catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate.; Cofactor: contains 3. 3 zinc atoms and no significant manganese.; Function: apn1 of S. cerevisiae accounts for > 97% of both apurinic/apyrimidinic (ap) endonuclease and DNA 3'-repair diesterase activities.; Remark: based on sequence similarity to apn1 of S. cerevisiae an additional intron might be present around AA position 290 (length approx. 30 AA).; Similarity: belongs to ap endonucleases family 2.; Title: strong similarity to apurinic endonuclease Apn1 - Saccharomyces cerevisiae; nucleus; See PMID 1693433
An11g02020	Function: GPT of Z. mays mediates a 1:1 exchange of glucose 6-phosphate mainly with inorganic phosphate and triose phosphates.; Remark: GPT was isolated from plastids of Z. mays,its expression is mainly restricted to heterotrophic tissues.; Similarity: closest manual homologue (BLASTP): PIR:T01210 glucose-6-phosphate/phosphate-translocator precursor - Zea mays.; Title: similarity to glucose-6-phosphate/phosphate-translocator GPT - Zea mays [putative sequencing error]; putative sequencing error; See PMID 9477574
An11g02030	Title: similarity to hypothetical protein T23E23.20 - Arabidopsis thaliana
An11g02040	Catalytic activity: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.; Title: strong similarity to phosphogluconate dehydrogenase Gnd1 - Saccharomyces cerevisiae; See PMID 1328471
An11g02050	Function: RBD (RNA binding) proteins can enhance hybridization of complementary RNAs and may thus mediate the interaction of sense and antisense RNA.; Remark: DdRBP1 is present in equal amounts throughout the developmental cycle of D. discoideum while differential accumulation is observed in nuclei during early and late development.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs the the RNP-CS family.; Title: similarity to ssRNA-binding protein DdRBP1 -Dictyostelium discoideum; See PMID 9426195
An11g02060	Remark: protein contains a possible DNA helicase subunit motif.; Title: similarity to hypothetical protein encoded by An12g03730 - Aspergillus niger
An11g02070	Title: strong similarity to hypothetical protein encoded by An01g14430 - Aspergillus niger
An11g02090	Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa
An11g02100	Complex: F26G of C. speciosus is a heterodimer of a 54kDa (CSF26G1) chain and 58kDa chain.; Function: F26G of C. speciosus catalyses the removal of C-26-bound glucose moiety of furostanol glycosides.; Remark: F26G of C. speciosus is strongly inhibited by diosgenin.; Similarity: F26G of C. speciosus belongs to the superfamily of Agrobacterium beta-glucosidases.; Similarity: similarity to many beta-Glucosidases which hydrolyse the terminal, non-reducing beta-D-glucose residue and release beta-D-glucose.; Title: strong similarity to furostanol glycoside 26-O-beta-glucosidase CSF26G1 - Costus speciosus; See PMID 8549824; See PMID 8766714
An11g02110	Function: SNQ2 of S. cerevisiae confers hyper-resistance to the mutagens 4-nitroquinoline-n-oxide (4-nqo) and triaziquone, as well as to the chemicals sulphomethuron phenanthroline when present in multiple copies.; Function: SNQ2 of S. cerevisiae exhibits nucleoside triphosphatase activity.; Function: SNQ2 of S. cerevisiae is an atp-dependent permease.; Localization: integral membrane protein.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to multidrug ATP binding cassette transporter Snq2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8437567; See PMID 7629127
An11g02120	Similarity: other similarities are based on repetitive sequences.; Title: strong similarity to hypothetical protein CAD79691.1 - Neurospora crassa
An11g02140	Function: TIM17 of S. cerevisiae is a 16. 5 kda inner membrane protein required for import of mitochondrial precursor proteins.; Remark: SMS1 = MIM17 = TIM17.; Remark: deletion of TIM17 in S. cerevisiae is lethal.; Title: strong similarity to mitochondrial inner membrane protein involved in protein import Tim17 -Saccharomyces cerevisiae; inner membrane; See PMID 8050569; See PMID 7919535
An11g02150	Function: ARO9 (first step of tryptophan,phenylalanine, and tyrosine catabolism) and YDR380w (named ARO10) have similar patterns of transcriptional regulation and are both under the positive control of Aro80p.; Remark: ARO80 is synonymous to YDR421w.; Similarity: ARO80 of S. cerevisiae belongs to the Zn2Cys6 transcription factor family.; Title: strong similarity to transcription factor Aro80 - Saccharomyces cerevisiae; See PMID 10207060
An11g02160	Catalytic activity: 4-Maleylacetoacetate = 4-Fumarylacetoacetate.; EC:5.2.1.2.; Function: maiA of A. nidulans is part of the phenylalanine catabolic pathway.; Similarity: maiA shows strong amino acid sequence similarity to glutathione S-transferases.; Title: strong similarity to maleylacetoacetate isomerase maiA - Aspergillus nidulans; See PMID 9417084
An11g02170	Catalytic activity: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.; Function: use of phenylalanine and phenylacetate as a carbon source.; Induction: by phenylacetate (PhOAc), 2OH-PhOAc,3OH-PhOAc, 4OH-PhOAc, phenylalanine, and tyrosine.; Induction: not induced by acetate or glutamate.; Pathway: last step in the metabolism of tyrosine.; Remark: disruption of the fah gene results in phenylalanine toxicity, secretion of succinylacetone and the absence of growth. This is analogous to the genetic disease, type I hereditary tyrosinaemia (ht1) in humans.; Repression: expression is partially repressed by glucose.; Title: strong similarity to fumarylacetoacetate hydrolase fahA - Aspergillus nidulans; See PMID 7568087
An11g02180	Catalytic activity: 3,4-dihydroxyphenylacetate + O(2) = 2-hydroxy-5-carboxymethylmuconate semialdehyde.; Function: HmgA of A. niger catalyzes an essential step in phenylalanine catabolism.; Remark: cofactor is iron.; Title: strong similarity to 3,4-dihydroxyphenylacetate 2,3-dioxygenase hmgA - Aspergillus nidulans; See PMID 7673153
An11g02190	Title: strong similarity to hypothetical protein CAD70480.1 - Neurospora crassa
An11g02200	Catalytic activity: 4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).; Pathway: participates in the catabolism of tyrosine.; Remark: tcrP of C. immitis is capable of eliciting a proliferative response in a T-cell line that is developed to respond to the soluble conidial wall fractions.; Similarity: belongs to the 4HPPD family.; Title: strong similarity to 4-hydroxyphenylpyruvate dioxygenase tcrP - Coccidioides immitis; See PMID 7642122
An11g02220	Remark: similarity to SPBC18H10. 09 of S. pombe is based on C-terminus of protein.; Title: similarity to hypothetical protein SPBC18H10.09 - Schizosaccharomyces pombe
An11g02230	Function: CYP51 of P. italicum catalyses C14-demethylation of lanosterol which is critical for ergosterol biosynthesis.; Function: CYP51 of P. italicum transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.; Pathway: ergosterol biosynthesis.; Remark: CYP51 of P. italicum is inhibited by fungicides.; Remark: mutations in CYP51 or overexpression of CYP51 confers fungicide resistance.; Similarity: CYP51 of P. italicum belongs to the superfamily of human cytochrome P450 CYP51.; Title: strong similarity to lanosterol 14 alpha-demethylase (P450(14DM)) CYP51 - Penicillium italicum; See PMID 8628233; See PMID 9717384; See PMID 10885830
An11g02270	Similarity: the similarity involves only the N-terminal 15% of the total protein length.; Title: strong similarity to hypothetical protein EAA65021.1 - Aspergillus nidulans
An11g02340	Title: questionable ORF
An11g02360	Complex: hetero-oligomeric complex of about 850 to 900 kd that forms two stacked rings, 12 to 16 nm in diameter.; Function: CCT5 from H. sapiens assist the folding of proteins upon atp hydrolysis and is known to play a role in the folding of actin and tubulin in vitro.; Similarity: belongs to the tcp-1 chaperonin family.; Title: strong similarity to T-complex protein 1 epsilon subunit CCT5 - Homo sapiens; cytoplasm; See PMID 7788527
An11g02365	Title: weak similarity to TRF2-interacting telomeric protein RAP1 - Homo sapiens
An11g02370	Function: the function of CTR86 of S. cerevisiae is not yet clear, but the fact that the upstream region contains a GCN4 responsive site suggests that the gene product may also be involved in amino acid biosynthesis.; Similarity: the ORF is much longer than the yeast protein (1322 compared to 563 amino acids).; Similarity: the ORF shows similarity to the yeast protein over a C-terminal stretch of about 100 amino acids.; Title: similarity to hypothetical protein Ctr86 -Saccharomyces cerevisiae; See PMID 2204248
An11g02380	Catalytic activity: GTP + alpha-D-Mannose 1-phosphate = Pyrophosphate + GDPmannose.; Function: MPG1 of H. jecorina is involved in the early steps of protein glycosylation.; Function: Mpg1 from H. jecorina was cloned as supressor of the S. cerevisiae mutation in the DPM1 gene encoding mannosylphosphodolichol synthase.; Function: overexpression of Mpg1 in H. jecorina gene also increased the transcription of the dpm1 gene and DPMS activity.; Function: overexpression of Mpg1 in H. jecorina led to a twofold increase in GDP-mannose (GDPMan) levels.; Remark: Hypocrea jecorina is also called Trichoderma reesei.; Title: strong similarity to GTP:alpha-D-mannose-1-phosphate guanylyltransferase MPG1 -Hypocrea jecorina; See PMID 9644208; See PMID 12902219
An11g02390	Function: Mx proteins are members of a family of interferon-inducible genes expressed when cells are treated with double-stranded RNA or virus infection. They are GTPases with an antiviral activity.; Title: strong similarity to antiviral determinants Mx1 - Rattus norvegicus; See PMID 2173790; See PMID 7507812
An11g02400	Catalytic activity: ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys).; Remark: alternate names for S. cerevisiae Krs1: GCD5 or YDR037W.; Title: strong similarity to cytosolic lysine--tRNA ligase Krs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2903861; See PMID 8952483
An11g02420	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to viral protein EBNA-1 -EpsteinBarr virus TsBB6
An11g02430	Function: the Cox15 protein from S. cerevisiae is required for the assembly of yeast cytochrome c oxidase.; Remark: alternate name for S. cerevisiae Cox15: YER141w.; Similarity: the ORF encoded protein shows also strong similarity to the human secreted protein described in patent WO9926973-A1.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox15 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9228094
An11g02440	Title: strong similarity to hypothetical secreted protein SCF41.31c - Streptomyces coelicolor
An11g02450	Function: the EryBIV aldohexose 4-ketoreductases is part of the eryB gene cluster from S. erythraea which is involved in the L-mycarose biosynthesis.; Pathway: the eryA (polyketide synthase genes), eryB (L-mycarose biosynthesis genes) and the eryC (D-desosamine biosynthesis genes) gene clusters from S. erythraea are involved in the erythromycin biosynthetic pathway.; Remark: the EryBIV aldohexose 4-ketoreductase from S. erythraea is identical to the protein described in patent WO9905283-A2.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins YLL056c from S. cerevisiae and SPBC2A9. 02 from S. pombe.; Title: similarity to aldohexose 4-ketoreductase EryBIV - Saccharopolyspora erythraea; See PMID 9353926; See PMID 9393448; See PMID 9563840
An11g02460	Function: the nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 10584035; See PMID 7993094
An11g02470	Remark: the ORF encoded protein is N-terminally extended in comparison to all other matching homologs.; Title: similarity to hypothetical protein F27J15.2 -Arabidopsis thaliana
An11g02480	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. stutzeri catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990
An11g02490	Title: weak similarity to endocarditis specific antigen region from patent WO9520658-A2 - Streptococcus oralis
An11g02500	Catalytic activity: Dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: the human GGPPS enzyme also catalyzes: geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Catalytic activity: the human GGPPS enzyme also catalyzes: trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Function: the human GGPPS enzyme catalyzes the trans-addition of the three molecules of IPP (isopentenyl diphosphate) onto DMAPP(dimethylallyl diphosphate) to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylatedgeranylated proteins.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Homo sapiens; See PMID 10026212
An11g02510	Pathway: the cytochrome P450 monooxygenase TRI4 from M. roridum is involved in the biosynthesis of trichothecenes, which are toxic sesquiterpenoids produced by certain fungi and plants.; Remark: the M. roridum TRI4 gene can successfully complement a F. sporotrichioides TRI4-mutant.; Title: similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 9529523
An11g02520	Catalytic activity: S-adenosyl-L-methionine + G(5')PPPR-RNA <=> S-adenosyl-L-homocysteine + m7G(5')PPPR-RNA.; Function: CaAbd1 from C. albicans transfers a methyl group from S-adenosylmethionine to the N7 position of guanine of the mRNA cap.; Remark: CaAbd1 expressed as a fusion with glutathione S-transferase (GST) displayed cap MTase activity in vitro. it also rescued S. cerevisiae abd1delta null mutants.; Title: strong similarity to mRNAcap-guanine-N7-methyltransferase CaAbd1 - Candida albicans; See PMID 10589710
An11g02530	Title: similarity to hypothetical protein CAF06139.1 - Neurospora crassa
An11g02540	Function: the recombinant mitochondrial 2-oxoglutarate/malate translocator (clone OMT103) from Panicum miliaceum reconstituted in liposomes efficiently transported malate, citrate, and 2-oxoglutarate.; Title: strong similarity to mitochondrial 2-oxoglutarate/malate translocator clone OMT103 - Panicum miliaceum; localisation:mitochondrion; See PMID 8616243
An11g02550	Catalytic activity: ATP + oxaloacetate <=> ADP + phosphoenolpyruvate + CO(2). -; Complex: Homotetramer.; Pathway: the phosphoenolpyruvate carboxykinase(KlPck1 K. lac. or Pck1 S. cer.) is the rate-limiting gluconeogenic enzyme.; Remark: the KlPCK1 gene from K. lactis restored PEPCK activity in a pck1 mutant of S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the phosphoenolpyruvate carboxykinase from Z. japonica described in patent JP09065886-A.; Title: strong similarity to phosphoenolpyruvate carboxykinase KlPck1 - Kluyveromyces lactis; See PMID 9717242
An11g02560	Remark: N-terminally truncated ORF due to the end of contig.
An11g02580	Remark: The C. albicans CNH1 gene is able to functionally complement the salt-sensitivity of a S. cerevisiae ena1 nha1 mutant.; Title: strong similarity to Na+/H+ antiporter Cnh1 -Candida albicans; plasma membrane; See PMID 10832630
An11g02590	Title: strong similarity to peroxisomal membrane protein Pmp27 - Saccharomyces cerevisiae; See PMID 7721939; See PMID 7860627; See PMID 8553699
An11g02600	Remark: PT2 expression in S. cerevisiae complements the pho84 mutant phenotype.; Title: strong similarity to PT2/PHT4 Phosphate transporter - Arabidopsis thaliana; plasma membrane; See PMID 9872450; See PMID 8927627
An11g02610	Complex: the S. cerevisiae homolog Rpn7p is subunit of the 19S proteasome regulatory subunit.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn7 - Saccharomyces cerevisiae
An11g02620	Catalytic activity: L-alanine + 2-oxoglutarate <=> pyruvate + L-glutamate.; Function: the H. vulgare homolog ALA2 encodes a hypoxically inducible alanine aminotransferase.; Title: strong similarity to alanine transaminase ALA2 - Hordeum vulgare; See PMID 8123785
An11g02630	Title: strong similarity to hypothetical protein SPCC1235.03 - Schizosaccharomyces pombe
An11g02640	Function: catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. -; Title: strong similarity to peptide methionine sulfoxide reductase MSRA - Streptococcus pneumoniae; See PMID 7934910; See PMID 8755589
An11g02650	Title: strong similarity to hypothetical gtpase activating protein SPAC824.09c - Schizosaccharomyces pombe
An11g02660	Remark: facB of A. niger encodes a Zn(II)2Cys6 transcriptional activator.; Remark: the facB gene from A. niger is similar to the facB gene from A. nidulans, which is a major regulatory gene involved in acetamide and acetate utilisation.; Title: similarity to hypothetical acetate regulatory DNA binding protein facB - Aspergillus niger
An11g02670	Title: strong similarity to hypothetical protein SPBC1703.02 - Schizosaccharomyces pombe
An11g02680	Title: similarity to proteophosphoglycan ppg1 -Leishmania major; plasma membrane; See PMID 10531342
An11g02690	Function: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation-; Remark: facB of Aspergillus nidulans encodes a Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An11g02700	Function: Haa1 of S. cerevisiae regulates the transcription of a set of yeast genes, many of which encode membrane proteins.; Localization: Haa1 is located in the nucleus.; Remark: synonyms for Haa1 of S. cerevisiae are YPR008w and CAA88786. 1.; Title: similarity to transcriptional activator Haa1 - Saccharomyces cerevisiae; See PMID 11504737
An11g02720	Title: similarity to hypothetical protein C50F7.2 -Caenorhabditis elegans
An11g02730	Title: similarity to hypothetical serine-rich protein SPCC1322.10 - Schizosaccharomyces pombe
An11g02750	Function: creC of A. nidulans is involved in carbon catabolite repression.; Similarity: the creC gene of A. nidulans was cloned and found to encode a protein which contains five WD40 motifs.; Title: strong similarity to hypothetical protein involved in carbon catabolite repression creC - Aspergillus nidulans; See PMID 10852476
An11g02760	Similarity: shows similarity to several known ras-related GTPases,; Title: strong similarity to protein involved in vesicle transport in the secretory pathway YAL048c -Saccharomyces cerevisiae; See PMID 10860831; See PMID 10949581; See PMID 10220001
An11g02770	Title: strong similarity to hypothetical protein CAB62422.1 - Schizosaccharomyces pombe; See PMID 1372395; See PMID 7802869; See PMID 8479540
An11g02780	Function: Zds2 from S. cerevisiae is a multicopy suppressor of a sin4 defect.; Remark: alternate names for Zds2 from S. cerevisiae are Ces4 and Yml109w.; Title: weak similarity to multicopy suppressor Zds2 - Saccharomyces cerevisiae; See PMID 8816438; See PMID 10398844
An11g02785	Title: strong similarity to hypothetical SNARE protein - Schizosaccharomyces pombe
An11g02830	Remark: Overproduction of Rod1p leads to resistance to not only o-DNB but also zinc and calcium. N-terminus truncated due to end of contig.; Title: similarity to resistance to o-dinitrobenzene protein Rod1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 8621680
An11g02840	Title: strong similarity to hypothetical protein SPAC637.13c - Schizosaccharomyces pombe
An11g02860	Catalytic activity: (R)-S-lactoylglutathione <=> glutathione + methylglyoxal.; Function: the S. cerevisiae homolog GLO1 encodes glyoxalase I which is required for detoxification of methylglyoxal.; Remark: the S. cerevisiae homolog Glo1p is regulated by the HOG (high osmolarity glycerol)-MAP (mitogen-activated protein) kinase pathway in osmotic stress response.; Title: strong similarity to glyoxalase I Glo1 -Saccharomyces cerevisiae; See PMID 9446611; See PMID 8824231
An11g02870	Remark: The niaD and niiA genes of Aspergillus nidulans genes are under the control of the positively acting nirA transcription factor, which mediates nitrate induction.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 10075929; See PMID 1922075; See PMID 7565720
An11g02890	Title: weak similarity to hypothetical protein encoded by An09g01250 - Aspergillus niger
An11g02910	Remark: The weak similarity to caldesmon is only based on repetitive sequences.
An11g02920	Title: similarity to hypothetical protein encoded by An09g01520 - Aspergillus niger
An11g02940	Title: weak similarity to hypothetical protein encoded by An09g01510 - Aspergillus niger
An11g02950	Function: calpains are calcium-activated non-lysosomal thiol-proteases. Calpains show preferential cleavage: Lyr-|-xaa, Met-|-xaa or Arg-|-xaa with Leu or Val as the P2 residue.; Similarity: the ORF encoded protein belongs to the peptidase family C2, also known as the calpain family of thiol proteases.; Title: similarity to calpain nCL-3 from patent DE19650142-A1 - Mus musculus; deleted EC_number 3.4.22.17
An11g02960	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Complex: the E. nidulans NimX kinase forms a stable but non-covalent complex with a regulatory subunit (Suc1) and with a cyclin.; Remark: the Emericella nidulans NimX kinase is able to complement the Schizosaccharomyces pombe cdc2-33 mutation.; Similarity: NimX from E. nidulans belongs to the Ser/Thr family of protein kinases and the Cdc2/CdkX subfamily.; Title: strong similarity to protein kinase functional homolog of cdc2 nimX - Aspergillus nidulans; deleted EC_number 2.7.1.37; See PMID 10601021; See PMID 7962194
An11g02970	Function: the human ABH protein is probably involved in the repair of alkylated DNA. It provides resistance to alkylating agents. When human ABH was expressed in E. coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.; Title: similarity to DNA alkylation damage repair protein and AlkB homolog ABH - Homo sapiens; See PMID 8600462
An11g02980	Catalytic activity: a monocarboxylic acid amide + H(2)O <=> a monocarboxylate + NH(3).; Function: the AmdS acetamidase allows Aspergillus oryzae acetamide to use as a sole carbon or nitrogen source.; Similarity: the ORF encoded protein is identical to the internal consensus fragment of the A. niger acetamidase described in patent EP758020-A2.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 1840550
An11g02990	Remark: astaxanthin is a ketocarotenoids employed for food coloration.; Similarity: the ORF encoded protein belongs to the cytochrome P450 family.; Title: strong similarity to astaxanthin synthetase from patent EP1035206 - Phaffia rhodozyma
An11g03000	Title: strong similarity to carnosinase 2 polypeptide HC2 from patent EP1122307-A1 - Homo sapiens
An11g03020	Title: weak similarity to platenolide synthase ORF3 protein from patent EP791656-A2 - Streptomyces ambofaciens
An11g03040	Remark: C-terminally truncated ORF due to the end of contig.; Title: weak similarity to hypothetical drebrin E2 -Mus musculus [truncated ORF]
An11g03050	Remark: C-terminally truncated ORF due to the end of contig.; Similarity: the ORF DNA sequence is strong similar to the EST an_3239 from Aspergillus niger .; Similarity: the similarities of the ORF encoded protein to all matches with an e-val less than 1e-05 are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein SPBC13G1.05 - Schizosaccharomyces pombe [truncated ORF]
An11g03060	Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Title: strong similarity to salicylate hydroxylase sal - Pseudomonas putida; See PMID 2916843; See PMID 10920265
An11g03070	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to chitinase chiA -Aspergillus nidulans
An11g03090	Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An11g03100	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the E. nidulans kinase PHOA is proposed to function to help integrate environmental signals with developmental decisions to allow ordered differentiation of specific cell types in E. nidulans under varying growth conditions.; Title: strong similarity to cyclin-dependent protein kinase phoa - Aspergillus nidulans; deleted EC_number 2.7.1.37; See PMID 9670015
An11g03110	Catalytic activity: Methanol + NAD(+) <=> formaldehyde + NADH.; Function: the methanol dehydrogenase Mdh from B. methanolicus C1 catalyzes the reversible oxidation of methanol to formaldehyde using NAD+.; Similarity: the methanol dehydrogenase Mdh from B. methanolicus C1 belongs to the iron-containing alcohol dehydrogenase family.; Title: strong similarity to methanol dehydrogenase Mdh - Bacillus methanolicus; See PMID 1644761
An11g03120	Function: XynD from Bacillus polymyxa catalyzes the hydrolysis of 1,4-beta-xylosidic linkages in xylans.; Similarity: XynD from Bacillus polymyxa belongs to family 43 of glycosyl hydrolases.; Title: similarity to endo-1,4-beta-xylanase XynD -Bacillus polymyxa; See PMID 1938968
An11g03130	Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger
An11g03150	Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Similarity: the ORF encoded protein shows also strong similarity to the 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens strain TN5 described in patent JP09121864-A.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715
An11g03160	Title: weak similarity to hypothetical BcDNA:GH11973 - Drosophila melanogaster
An11g03170	Title: similarity to hypothetical phosphoglycerate mutase SPAC5H10.03 - Schizosaccharomyces pombe
An11g03180	Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Remark: similarity to the human ubiquitin-conjugating enzyme E6AP patent WO9518974-A.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Similarity: belongs to the hect-type e3 ubiquitin-protein ligase domain proteins.; Title: similarity to ubiquitin-ligase E6AP from patent WO9518974-A - Homo sapiens; See PMID 7708685
An11g03190	Title: weak similarity to parasporal crystal protein C53 - Bacillus thuringiensis
An11g03200	Function: inulinases catalyse the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin.; Gene-ID: inuA; Remark: only this ORF with a match to the endoinulinase gene inuA from A. niger could be found; inuB is missing, probably due to strain differences.; Remark: the predicted ORF differs from 1 to 15 amino acids from the published sequences of inulinases from A. niger.; Similarity: the predicted ORF shows strong similarity to EMBL:AB012771 A. niger inuA gene for inulinase and EMBL:AB012772 A. niger inuB gene for inulinase.; Similarity: the predicted ORF shows strong similarity to both isoenzymes with inulinase activity in A. niger, inuA and inuB.; See PMID 9805373
An11g03210	Function: glycosyl hydrolases catalyse the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; Remark: the conserved regions characteristic for glycosyl hydrolases is located in the N-terminal section,which was not alligned with the predicted ORF.; Remark: three putative frameshifts due to possible sequencing errors were corrected: at position 13219 one missing bp, at position 13245 one missing bp and at position 13433 one bp too much.; Similarity: the inner region of the predicted ORF (amino acid 40 to 120) shows similarity to several glycosyl hydrolases from different species, which display various substrat specificities.; Similarity: the predicted ORF overlaps with EMBL:AB012771 A. niger inuA gene for inulinase.; Title: strong similarity to sucrose:sucrose 1-fructosyltransferase AFSS1FRUC_1 - Aspergillus foetidus [putative frameshift]; putative frameshift; See PMID 9495772
An11g03220	Function: GAL4 of S. cerevisiae activates the transcription of several genes involved in galactose metabolism.; Remark: the systematic name for GAL4 of S. cerevisiae is YPL248C.; Similarity: the predicted ORF shows similarity to several 6-cysteine zinc finger-containing transcription factors from different species.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 1892477; See PMID 6366516; See PMID 8312971
An11g03230	Function: cytochrome P450 enzymes usually act as terminal oxidases of a variety of structurally unrelated combounds (erg5 is a C-22 sterol desaturase, which is involved in ergosterol biosynthesis) in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: the predicted ORF shows similarity to several cytochrome P450 isozymes from different species.; Title: strong similarity to cytochrome P450 sterol delta22-desaturase Erg5 - Saccharomyces cerevisiae; See PMID 8635732; See PMID 10770760
An11g03240	Catalytic activity: ard of C. tropicalis converts D-arabinitol + NAD(+) = D-ribulose + NADH.; Function: ard of C. tropicalis is a NAD-dependent short-chain alcohol dehydrogenase which catalyzes the NAD(+)-dependent oxidation at carbon 4 to yield D-ribulose.; Similarity: the predicted ORF overlaps with EMBLEST:BE760294 A. niger.; Similarity: the predicted ORF shows strong similarity to several oxidoreductases/short chain dehydrogenase from several species, which display different specificities.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655; See PMID 8250887
An11g03250	Remark: the predicted ORF is questionable due to the suboptimal intron-exon structure.; Title: questionable ORF
An11g03260	Function: due to the similarity to several oxidoreductases, it is assumed that the A. niger gene encodes for a member of the short-chain dehydrogenase family with yet unknown specificity.; Function: sou1 of C. albicans is a sorbitol utilization protein required for L-sorbose assimilation.; Similarity: the predicted ORF shows similarity to oxidoreductases/short-chain dehydrogenase (SDR) from several species, which display different specificities.; Title: strong similarity to short-chain dehydrogenase sou1 - Candida albicans; See PMID 7742302
An11g03270	Function: due to the similarity to DNA-binding proteins, it is assummed that the predicted A. niger gene encodes for a protein involved in transcription.; Similarity: the predicted ORF shows similarity to several zinc finger-containing proteins from different species.; Title: strong similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe
An11g03290	Similarity: the predicted ORF shows similarity to several probable membrane proteins from different species.; Similarity: the similarity of the predicted ORF to the homologues proteins is locally high in the N-terminal part containing the two domains with unknown fuction, the DUF21 transmembrane domain and the CBS domain, spanning the region from amino acid 50 to 400.; Title: strong similarity to hypothetical membrane protein YOL060c - Saccharomyces cerevisiae
An11g03300	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An11g03310	Function: due to the presence of clusters COG0419 and COG1196, it is assumed that the predicted ORF encodes a protein, which has ATPase activity and might be located in the nucleus.; Similarity: the predicted ORF shows similarity to myosin heavy chain proteins from several species.; Similarity: the similarity to myosin heavy chain is resticted to the C-terminal myosin tail, which includes 28-residue repeats that are characteristic for alpha-helical coiled coils, but does not include the ATP-binding and actin-binding domains.; Title: strong similarity to myosin heavy chain -Oryctolagus cuniculus
An11g03320	Remark: the ORF is questionable due to its short lenght of only 29 amino acids.; Title: questionable ORF
An11g03330	Remark: the similarity of the predicted ORF to DNA-directed RNA polymerase from several species is due to the presence of a serine/proline-rich region in the ORF,which does not contain conserved repeats and is therefore not homologues.; Similarity: the similarity of the predicted ORF to the putative protein B23L21. 390 of N. crassa is locally high in the N-terminal part ending around amino acid 400.; Title: strong similarity to hypothetical protein B23L21.390 - Neurospora crassa
An11g03340	Catalytic activity: alpha-amylase of A. niger catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Function: alpha-amylase of A. niger is a glycosyl hydrolase involved in glycogen and starch degradation.; Induction: alpha-amylase of A. niger binds a calcium ion, which is required for its activity.; Similarity: the predicted ORF is nearly identical with the database entry alpha-amylase of A. niger, but differs at amino acid position 254 of the database protein and the predicted ORF is 21 amino acids longer at the N-terminus (sequencing error?).; Similarity: the predicted ORF shows similarity to several A. niger ESTs in the patent and the EMBL database.; See PMID 2207069
An11g03350	Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Similarity: the predicted ORF overlaps the promoter region of the 3' ORF and therefore shows similarity to entry EMBL:A00848 A. niger (acid-stable alpha-amylase promoter and upstream activating sequences) and PATENTDNA:AAN91276 (DNA encoding N-terminus A. niger acid stable alpha-amylase plus signal peptide and promoter and upstream activating sequences).; Similarity: the predicted ORF shows similarity to multidrug transporter from different species and with various specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe
An11g03360	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An11g03370	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An11g03380	Catalytic activity: lysophospholipases convert 2-lysophosphatidylcholine + H(2)O <=> glycerophosphocholine + a fatty acid anion; Function: lysophospholipases are involved in the degradation of phospholipids.; Similarity: the predicted ORF shows similarity to several putative phospholipases from different species,most of which are lysophospholipases.; Title: similarity to monoglyceride lipase mgll - Mus musculus; See PMID 9341166; See PMID 10627494
An11g03390	Similarity: the similarity of the predicted ORF to the conserved hypothetical protein and to other protein matches is restricted to its N-terminal part reaching from amino acid 1 to 220, but the conserved SH3-domain in the C-terminal region of the S. pombe protein is not homologues.; Title: strong similarity to hypothetical protein CAB62422.1 - Schizosaccharomyces pombe
An11g03400	Title: strong similarity to hypothetical protein encoded by An12g06660 - Aspergillus niger
An11g03420	Function: Rex1p of S. cerevisiae is required for 5S rRNA and tRNA-Arg3 maturation.; Function: Rnh70p of S. cerevisiae is thought to be involved in DNA replication.; Remark: the systematic gene name of RNH70/REX1 of S. cerevisiae is YGR276c.; Title: similarity to ribonuclease H/3-5 exonuclease Rnh70 - Saccharomyces cerevisiae; nucleus; See PMID 10359084; See PMID 10716935
An11g03430	Function: ord1 of A. flavus converts O-methylsterigmatocystin to aflatoxin B1.; Pathway: ord1 of A. flavus catalyzes the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: belongs to the CYP64 family of cytochrome P450-type monooxygenases.; Title: strong similarity to hypothetical O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099
An11g03450	Title: strong similarity to hypothetical protein dag11 - Agaricus bisporus
An11g03460	Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the C-terminus contains 8 WD40-like (beta-transducin) repeats.; Title: strong similarity to vegetative incompatibility factor het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An11g03470	Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta; endoplasmatic reticulum; See PMID 7764227; See PMID 8882724; See PMID 9349702
An11g03480	Title: strong similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger
An11g03490	Function: actVB-orf11 of S. coelicolor is possibly involved in actinorhodin biosynthetis.; Similarity: belongs to the short-chain alcohol dehydrogenases family.; Title: strong similarity to hypothetical oxidoreductase actVB-orf11 - Streptomyces coelicolor; See PMID 10400594
An11g03500	Catalytic activity: L-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Complex: CYB2 of S. cerevisiae is a homotetramer.; Induction: CYB2 of S. cerevisiae is induced during respiratory adaptation and by L-lactate.; Localization: CYB2 of S. cerevisiae is located at the mitochondrial intermembrane space.; Similarity: a better match of the protein length is observed with peroxisomal glycolate oxidase (EC 1. 1. 3. 15) of Spinacia oleracea.; Similarity: belongs to the FMN-dependent cytochrome b2 family.; Title: strong similarity to L-lactate dehydrogenase precursor Cyb2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3004948
An11g03510	Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical transcriptional regulator PRO1 from Sordaria brevicollis.; Title: strong similarity to hypothetical protein encoded by An02g08760 - Aspergillus niger
An11g03520	Similarity: shows abundant unspecific matches to a variety of threonine-, serine- and glycine-rich proteins from diverse species.; Title: weak similarity to hypothetical protein encoded by An02g14500 - Aspergillus niger
An11g03530	Function: ttuB of A. vitis facilitates the cellular uptake of tartrate.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; plasma membrane; See PMID 7592429
An11g03540	Function: TRI11 of F. sporotrichioides converts isotrichodermin to 15-decalonectrin.; Pathway: TRI11 of F. sporotrichioides is involved in the biosynthesis of fungal toxins of the trichothecene family.; Pathway: the product of the reaction catalyzed by TRI11 of F. sporotrichioides, 15-decalonectrin, is the starting point for various branches of trichothecene biosynthesis pathways leading to different trichothecene species.; Similarity: belongs to the superfamily of cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An11g03570	Function: TRI4 of F. sporotrichioides is a cytochrome P450-type monooxygenase of the CYP58 subfamily.; Pathway: TRI4 of F. sporotrichioides catalyzes the initial oxygenation step of trichothecene biosynthesis and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333
An11g03580	Catalytic activity: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.; Function: laccase of N. crassa is a multicopper oxidase containing type 1, type 2, and type 3 copper centers.; Pathway: laccase of N. crassa is probably involved in the degradation/detoxification of lignin and/or it's derivatives.; Title: strong similarity to precursor of laccase -Neurospora crassa; See PMID 2961749
An11g03590	Catalytic activity: digallate + H2O = 2 gallate.; Complex: tannase of A. oryzae forms a heterooctamer consisting of four pairs of the two different subunits.; Remark: the tannase precursor of A. oryzae is post-translationally cleaved in two subunits which are linked by a disulfide bond.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An11g03600	Function: CIH1 of C. lindemuthianum is involved in the establishment and maintenance of biotrophy.; Localization: the CIH1 glycoprotein is specifically located at the biotrophic interface formed in the C. lindemuthianum-bean interaction.; Title: similarity to intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; cell wall; See PMID 9721685
An11g03610	Function: ankyrins act as protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows strong similarity to domains of ankyrin.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021
An11g03620	Function: tfdA of B. sp. is involved in chlorocatechol degradation.; Title: strong similarity to 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase tfdA - Burkholderia sp.; See PMID 8779585
An11g03630	Title: similarity to hypothetical transcription factor Aro80 - Saccharomyces cerevisiae
An11g03640	Function: OPT1 of C. albicans mediates the cellular uptake of oligopeptides.; Function: OPT1 of C. albicans specifically transports tetra- and pentapeptides.; Title: strong similarity to transmemrane oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116
An11g03660	Similarity: mTMT of M. musculus belongs to the tryptase family of serine proteases but is distinguished by a hydrophobic, possibly membrane spanning, C-terminal extension.; Similarity: the N-terminus shows similarity to the N-terminal portion of the phospholipase A2 activating protein PLA2P of Homo sapiens.; Title: weak similarity to hypothetical transmembrane tryptase mTMT - Mus musculus; See PMID 10521469
An11g03670	Title: similarity to hypothetical reductase encoded by 2SCG18.20c - Streptomyces coelicolor
An11g03680	Catalytic activity: Cinnamyl alcohol + NADP(+) = cinnamaldehyde + NADPH.; Function: CAD of E. gunnii reduces hydroxycinnamyl aldehydes (sinapyl, paracoumaryl, coniferyl aldehydes) to the corresponding alcohols.; Pathway: CAD of E. gunnii catalyzes the final step in the production of monomeric lignin precursors.; Title: strong similarity to cinnamyl alcohol dehydrogenase CAD - Eucalyptus gunnii; See PMID 8490129
An11g03690	Function: UaY of A. nidulans binds to the sequence 5'-TCGG-6X-CCGA.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421
An11g03700	Function: HXT1p of U. fabae facilitates the uptake of D-glucose and D-fructose in the haustorial complex.; Localization: HXT1p of U. fabae is exclusivly located to the plasma membrane of the haustorial complex.; Title: strong similarity to hexose transporter HXT1 - Uromyces fabae; plasma membrane; See PMID 11390980
An11g03730	Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea
An11g03740	Function: isoamyl alcohol oxidase may play a role in the Ehrlich pathway of branched-chain amino acid utilization.; Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae
An11g03760	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An11g03770	Title: strong similarity to hypothetical blastomyces yeast phase-specific protein 1 related protein CAD70756.1 - Neurospora crassa
An11g03780	Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: strong similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe
An11g03790	Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor
An11g03800	Catalytic activity: salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2.; Function: sal of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Pathway: sal of P. putida is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Title: strong similarity to FAD-dependent salicylate hydroxylase sal - Pseudomonas putida; See PMID 8695632
An11g03810	Title: strong similarity to hypothetical protein mlr0979 - Mesorhizobium loti
An11g03820	Title: strong similarity to hypothetical flavoprotein oxygenase PA1644 - Pseudomonas aeruginosa
An11g03830	Title: similarity to hypothetical protein yciI -Escherichia coli
An11g03860	Function: ftsH2 of C. merolae is involved in mitochondrial division.; Function: the ATPases of the FtsH family are involved in the degradation of soluble and membrane proteins during organelle division or prokaryotic cell division.; Similarity: belongs to the family of ATPases associated with various cellular activities (AAA).; Title: similarity to mitochondrial ATP-dependent protease ftsH2 - Cyanidioschyzon merolae; See PMID 10598100
An11g03870	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to vegetative heterokaryon incompatibility factor het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402
An11g03880	Catalytic activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O.; Pathway: DDPS of B. methanolicus catalyzes the first step in diaminopimelate and lysine biosynthesis.; Similarity: homologous to protein of patent database entry PATENTPROT:AAB47100.; Title: strong similarity to dihydrodipicolinate synthase DDPS from patent EP1074626-A2 - Bacillus methanolicus
An11g03890	Similarity: B912. 10 of N. crassa is longer than the ORF (1004 compared to 738 amino acids). More than 100 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain typical for fungal transcriptional regulators.; Title: strong similarity to hypothetical conserved protein B9I2.10 - Neurospora crassa
An11g03900	Function: TNA1 of S. cerevisiae is necessary for cellular uptake of nicotinic acid at low concetrations.; Remark: the systematic gene name of TNA1 of S. cerevisiae is YGR260w.; Similarity: belongs to the major facilitator superfamily (MFS).; Similarity: shows strong homology to several hypothetical allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An11g03920	Function: lovF of A. terreus is a multifunctional enzyme required for the formation of 2-methylbutyrate which is subsequently assembled with monacolin J to form lovastatin.; Pathway: lovF of A. terreus is involved in lovastatin biosynthesis.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994
An11g03930	Similarity: shares a conserved motif (GPFDGILaFShGA,the lowercase letters represent residues deviating from the consensus) with a number of hypothetical proteins and the dihydrofolate reductase DFR1 of S. pombe.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical dihydrofolate reductase SPAC22A12. 06c from Schizosaccharomyces pombe.; Title: similarity to hypothetical protein encoded by An15g02140 - Aspergillus niger
An11g03940	Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta; endoplasmatic reticulum; See PMID 7764227; See PMID 8882724; See PMID 9349702
An11g03950	Function: AKT2 of Alternaria alternata encodes a protein of unknown function involved in the biosynthesis of the host-specific AK-toxin.; Similarity: belongs to the superfamily of alpha/beta hydrolases.; Title: similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635
An11g03960	Function: PTH11 of M. grisea is involved in pathogenicity signaling.; Function: PTH11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An11g03970	Similarity: belongs to the AAA family of ATPases.; Title: similarity to hypothetical AAA family ATPase SCD8A.32c - Streptomyces coelicolor
An11g03980	Similarity: related to coproporphyrinogen oxidase N-terminus.; Similarity: the ORF encoded protein shows similarities to the matching protein of A. niger only at the very N-terminus.; Title: weak similarity to hypothetical protein encoded by An12g05650 - Aspergillus niger
An11g03990	Title: weak similarity to hypothetical protein encoded by An18g02800 - Aspergillus niger
An11g04000	Function: WHIP of M. musculus is involved in aging control.; Localization: WHIP co-localizes with the Werner's syndrome helicase/exonuclease in granular structures in the nucleus.; Similarity: WHIP of M. musculus is highly conserved from E. coli to human.; Similarity: related to DEAH-box subfamily of ATP-dependent helicases and other ATPases.; Title: strong similarity to Werner helicase interacting protein WHIP - Mus musculus; nucleus; See PMID 11301316
An11g04010	Function: Ppr1p of S. cerevisiae transcriptionally activates the structural genes URA1 and URA3.; Pathway: Ppr1p of S. cerevisiae regulates genes involved in the pyrimidine biosynthesis.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; See PMID 8668194; See PMID 6096561
An11g04020	Similarity: belongs to the carboxylesterases type-B family.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAY01820.; Title: similarity to esterase from patent JP11075860-A - Acetobacter pasteurianus
An11g04030	Catalytic activity: pnlA of G. cingulata catalyzes the eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Function: pnlA of G. cingulata is involved in pectin utilization.; Remark: Glomerella cingulata is used synonymous for Colletotrichum gloeosporioides.; Similarity: belongs to the polysaccharide lyase family 1.; Title: strong similarity to pectin lyase pnlA -Glomerella cingulata; extracellular/secretion proteins; See PMID 8181749
An11g04040	Catalytic activity: PGX1 of C. carbonum catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: PGX1 of C. carbonum is involved in the degradation of pectin.; Similarity: belongs to family 28 of glycosyl hydrolases.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185
An11g04050	Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear DNA-binding domain.; Title: similarity to hypothetical transcription regulator SPBP8B7.30c - Schizosaccharomyces pombe
An11g04060	Catalytic activity: IFR of M. sativa catalyzes the NADPH-dependent reduction of 2'-hydroxyformononetin stereospecifically to (3R)-vestitone.; Function: IFR of M. sativa introduces one of two chiral centers during the biosynthesis of the phytoalexin medicarpin.; Pathway: IFR of M. sativa participates in the biosynthesis of medicarpin, an antimicrobial phytoalexin,which is a product of the isoflavonoid branch of the phenylpropanoid pathway.; Title: similarity to isoflavone reductase IFR -Medicago sativa; See PMID 7866024; See PMID 1912490
An11g04070	Similarity: shares homology with a conserved N-terminal domain of various protein kinases from diverse species.; Title: weak similarity to polo-like kinase kinase xPlkk1 - Xenopus laevis
An11g04090	Function: AGA1 of S. cerevisiae is involved in cell surface attachment of a-agglutinin.; Similarity: also related to nitrate reductase beta chain of Streptomyces coelicolor.; Title: weak similarity to agglutinin attachment protein Aga1 - Saccharomyces cerevisiae; See PMID 2072914
An11g04100	Function: cdh of T. versicolor is involved in the degradation of lignocellulose.; Induction: cdh of T. versicolor is activated under cellulolytic conditions.; Similarity: the homology to cdh of T. versicolor is limited to it's N-terminal region.; Title: weak similarity to cellobiose dehydrogenase cdh - Trametes versicolor; See PMID 9573367
An11g04110	Similarity: contains two tetratricopeptide repeat (TPR) domains probably involved in protein-protein interactions.; Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor
An11g04120	Similarity: shows weak homology to a variety of protein kinases of diverse species.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein kinase F39F10. 3 from Caenorhabditis elegans.; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger
An11g04130	Similarity: shows a weak homology match to the protein patent database entry PATENTPROT:AAY19886.; Title: weak similarity to antigenic protein f688.aa from patent WO9859071-A1 - Borrelia burgdorferi
An11g04150	Catalytic activity: alcohol dehydrogenases catalyze the reversible oxidation of primary and secondary alcohols to aldehydes and ketones by NAD+: alcohol + NAD(+) <=> aldehyde or ketone + NaDH.; Remark: alternative names for adh2 are adr2 or YMR303C or YM9952. 05C.; Remark: in yeast are three isozymes of alcolhol dehydrogenase known, the adr2 preferentially catalyses the conversion of ethanol to acetaldehyde and is the glucose-repressed adh of yeast.; Similarity: the predicted ORF overlaps with the A. niger EST BE758920.; Title: strong similarity to alcohol dehydrogenase 2 Adh2 - Saccharomyces cerevisiae; cytoplasm; See PMID 3297923; See PMID 6279086
An11g04160	Function: mal23 of S. cerevisiae regulates the coordinate transcription of structural mal6S (maltase) and mal6T (maltose permease) genes.; Similarity: the predicted ORF shows similarity to the transcriptional activator of amylase genes amyR of A. niger.; Title: strong similarity to transcription activator Mal23 - Saccharomyces cerevisiae; nucleus; See PMID 9258674
An11g04168	Title: strong similarity to hypothetical protein AAD42396.1 - Zymomonas mobilis
An11g04180	Function: the chaperone bip is involved in quality control of protein folding.; Gene-ID: bipA; Mapping: bipA from A. niger is mapped to chromosome VII (LG VII); see EMBL Y08868.; endoplasmatic reticulum; See PMID 9370263; See PMID 9830095; See PMID 10653750
An11g04190	Remark: the predicted ORF is annotated as questionable ORF due to the presence of unusually long intron segments.; Title: questionable ORF
An11g04200	Similarity: the similarity of the predicted ORF to eEF1 alpha chain of C. albicabs is restricted to its C-termial end, starting at amino acid 402 of the predicted protein.; Title: strong similarity to translation elongation factor eEF1 alpha chain - Candida albicans; cytoplasm
An11g04210	Function: polyA ribonuclease subunit pan2 of S. cerevisiae is required for Pab1p-stimulated poly(A) ribonuclease activity.; Remark: alternate names for pan2 of S. cerevisiae are G3165 or YGL094c.; Similarity: the predicted ORF is identical with A. niger EST BE758876.; Title: strong similarity to polyA ribonuclease subunit Pan2 - Saccharomyces cerevisiae; cytoplasm; See PMID 8550599; See PMID 10669874
An11g04220	Catalytic activity: cytochrome P450 ALK2-A of C. maltosa catalyses the hydroxylation of n-alkanes at the terminal position.; Induction: the alkane-inducible cytochrome P450 protein family is inducible by alkanes.; Remark: the predicted ORF includes a motiv, that is specific for the cytochrome P450 protein family.; Title: strong similarity to cytochrome P450 alk2A -Candida maltosa
An11g04230	Similarity: due to the presence of a kinesin light chain motiv the predicted ORF shows similarity to kinesin light chain of several spezies.; Similarity: the similarity to kinesin light chain is restricted to the region with imperfect tandem repeats (TPR), which are believed to mediate protein-protein interactions.; Title: similarity to hypothetical protein BAB75479.1 - Nostoc sp.
An11g04240	Title: questionable ORF
An11g04250	Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Complex: the aminoadipate reductase enzyme is a heterodimer of a large (lys2) and a small subunit.; Function: lys2 of A. chrysogenum, as well as of S. cerevisiae, catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Pathway: lysine biosynthesis.; Similarity: the C-terminal half of the predicted ORF shows similarity to the oxidoreductase portion of several poorly characterized poliketide or secondary metabolite sinthases.; Similarity: the N-terminal part of the predicted ORF shows no similarity to known proteins.; Title: similarity to aminoadipate reductase enzyme lys2 - Acremonium chrysogenum; See PMID 11254122; See PMID 3928261
An11g04260	Similarity: the similarity to dihydrofolate reductase is limited to the N-terminal half of the protein.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538
An11g04270	Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered.; Similarity: lovC of A. terreus belongs to the Zn-containing oxidoreductases family.; Similarity: the predicted ORF shows a much stronger similarity to toxD of C. carbonum, a gene unique to isolates that make the cyclic peptide HC-toxin, but which has no role in toxin biosyntehsis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An11g04280	Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity.; Function: PKS1 of C. heterostrophus is required for the biosynthesis of the polyketide T-toxin.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to different fungal polyketide synthases, e. g. also to lovF of A. terreus, which is linked to lovC in the A. terreus genome.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776
An11g04290	Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases use NAD as electron exchanger.; Complex: rbtD of K. aerogenes is a homotetramer.; Similarity: rbtD of K. aerogenes belongs to short-chain, zinc-independent alcohol dehydrogenase family.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol dehydrogenases, with very wide substrate specificities.; Title: strong similarity to ribitol dehydrogenase rbtD - Klebsiella aerogenes; See PMID 3904726
An11g04310	Function: STAM of H. sapiens is a component of a signaling pathway promoting c-myc induction and cell growth in response to cytokine stimulation of lymphocytes.; Function: STAM of H. sapiens is associated with Jak3 and Jak2 tyrosine kinases and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively.; Similarity: STAM of H. sapiens, as well as the predicted ORF, contains an SH3 protein-protein interaction domain and a VHS domain, typical of proteins involved in membrane trafficking and signal transduction.; Similarity: the N-terminal part of the gene model is confirmed by identity to A. niger EST EMBLEST Acc. N. BE759424.; Similarity: the predicted ORF, in the N-terminal region, displays a very strong similarity to a putative protein of S. pombe; the last one shows similarity to human STAM too.; Title: strong similarity to signal transducing adaptor molecule STAM - Homo sapiens; See PMID 8780729; See PMID 9133424
An11g04320	Function: STE20 of S. cerevisiae is needed for mating in haploid cells, induction of a mating-specific gene Fus1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest.; Function: STE20 of S. cerevisiae is required to link the pheromone response G-protein signal to the downstream MAP-kinase cascade.; Similarity: the similarity of the predicted ORF to STE20 of S. cerevisiae is weak in the N-terminal region and particularly strong in the C-terminal part.; Similarity: to the conserved catalytic domains of Ser/Thr-protein kinases.; Title: strong similarity to serine/threonine kinase Ste20 - Saccharomyces cerevisiae; cytoplasm; See PMID 9024634
An11g04330	Title: questionable ORF
An11g04340	Catalytic activity: nucleobase (out) + H+ (out) --> nucleobase (in) + H+ (in).; Function: FCY2 of S. cerevisiae has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine.; Similarity: FCY2 of S. cerevisiae belongs to the nucleobase:cation symporter-1 family of transport proteins.; Title: strong similarity to cytosine/purine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 1541283; See PMID 2191181
An11g04360	Complex: SCP160 of S. cerevisiae binds RNA and single-stranded and double stranded DNA, and is associated with polyribosome complexes.; Function: SCP160 of S. cerevisiae is implicated in mRNA metabolism.; Localization: SCP160 of S. cerevisiae, as well as its vertebrate homologues vigilins, is associated via ionic interactions with the nuclear envelope and the endoplasmic reticulum.; Phenotype: the most noteworthy phenotype of SCP160 deletion mutants in S. cerevisiae is a decrease in viability and an increased number of chromosomes in the surviving cells.; Similarity: SCP160 of S. cerevisiae contains 14 KH domains, conserved motifs that have been identified in a variety of RNA-binding proteins; the predicted ORF contains 8 KH domains.; Title: strong similarity to polyribosome binding protein Scp160 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8533468; See PMID 9363784; See PMID 10710424
An11g04370	Remark: A novel type of RNA editing, in which the cDNA included either guanine insertion or adenine-->guanine substitution at one base upstream of poly(A), was observed with cytochrome b5 from M. alpina. .; Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to A. niger EST an_2954.; Title: strong similarity to cytochrome b5 -Mortierella alpina; See PMID 10348912
An11g04380	Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol.; Remark: acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.; Title: strong similarity to ubiquitin specific protease Ubp5 - Saccharomyces cerevisiae; See PMID 7871889; See PMID 11076031
An11g04400	Function: Vps27p in S. cerevisiae controls membrane traffic through the prevacuolar/endosomal compartment. S. cerevisiae Vps27p is a 'class E' protein involved in exit from the prevacuolar compartment. it is involved in forward transport to the vacuole as well as vesicle recycling to the Golgi.; Remark: Vps27p, like all class E proteins, probably participates in ubiquitin-mediated maturation of multivesicular bodies upon delivery to the yeast vacuole.; Title: strong similarity to vacuolar protein sorting-associated protein Vps27 - Saccharomyces cerevisiae; endosome; See PMID 10367894; See PMID 7593183
An11g04410	Title: similarity to hypothetical Cys2/His2-type zinc finger protein T18C15_3 - Arabidopsis thaliana
An11g04420	Title: strong similarity to protein mddt from patent WO200162922-A2 - Homo sapiens
An11g04450	Remark: all homology proteins have a single repetitive block.
An11g04460	Title: similarity to hypothetical protein SPAC4F10.07c - Schizosaccharomyces pombe
An11g04470	Remark: similarity to protein fragment SEQ ID NO: 19254 patent EP1033405-A2.; Remark: the Arabidopsis thaliana sequence is a putative protein fragment.; Title: similarity to protein fragment SEQ ID NO:19254 from patent EP1033405-A2 - Arabidopsis thaliana
An11g04480	Remark: RNA polymerase II holoenzymes have been described that consist of RNA polymerase II, a subset of general transcription factors, and four SRB proteins. The SRB proteins, which were identified through a selection for genes involved in transcription initiation by RNA polymerase II in vivo, are a hallmark of the holoenzyme.; Title: similarity to non-specific RNA polymerase II transcription factor Srb9 - Saccharomyces cerevisiae; See PMID 7774808; See PMID 8725217
An11g04500	Title: strong similarity to hypothetical protein B23L21.160 - Neurospora crassa
An11g04510	Function: involved in translation termination. Stimulates the activity of erf1. Binds guanine nucleotides.; Remark: SUP2 (SUP35) is an omnipotent suppressor gene, coding for an EF-1 alpha-like protein factor,intimately involved in the control of translational accuracy in yeast S. cerevisiae.; Remark: alternative names are GST1, SUP35, SUP36,SUF12, PNM2, SAL3.; Similarity: to GTP-binding elongation factors.; Title: strong similarity to suppressor 2 Sup2 -Saccharomyces cerevisiae; See PMID 3047009; See PMID 3280807
An11g04520	Title: strong similarity to hypothetical protein B23I11.70 - Neurospora crassa
An11g04530	Remark: the predicted ORF is related to DOS1 S. cerevisiae.; Title: similarity to hypothetical protein DOS1 -Neurospora crassa
An11g04540	Protein sequence is in conflict with the conceptual translation; Similarity: to neurofilament proteins.; Title: similarity to hypothetical protein DKFZp434F1017 - Homo sapiens [putative sequencing error]; putative sequencing error
An11g04550	Catalytic activity: Pyruvate + Lipoamide <=> S-Acetyldihydrolipoamide + CO2.; Cofactor: thiamin pyrophosphate.; Complex: the S. cerevisiae Pda1 protein is component of the multienzyme pyruvate dehydrogenase complex.; Function: the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-Coa & CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3).; Remark: alternative name for S. cerevisiae Pda1: YER178W.; Title: strong similarity to pyruvate dehydrogenase alpha subunit E1 alpha Pda1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1330555; See PMID 2202601
An11g04600	Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa
An11g04610	Title: weak similarity to cytochrome P450 CYP73A from patent FR2768748-A1 - Triticum aestivum
An11g04620	Complex: the yeast Proteasome is composed of 14 different subunits which form a highly ordered ring-shaped structure.; Function: the S. cerevisiae homolog Pup1p is the proteolytic active beta-2 proteasome subunit with a trypsin-like activity.; Localization: in S. cerevisiae the Proteasome is localized in the cytoplasm and in the nucleus.; Remark: the Proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.; Title: strong similarity to proteasome 20S subunit Pup1 - Saccharomyces cerevisiae; See PMID 9312134; See PMID 10393174
An11g04630	Function: the human Nup214 protein is component of the nuclear pore complex. It is exposed to the cytoplasmic side. It serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.; Remark: alternate names for the human nuclear pore complex protein Nup214: can or cain.; Title: similarity to nuclear pore complex Nup214 -Homo sapiens; nucleus; See PMID 9141635; See PMID 9488438
An11g04640	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.
An11g04650	Function: the human alpha CP-1 protein is member of the KH domain RNA binding protein family. It is involved in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_3511 from Aspergillus niger.; Title: similarity to alpha-complex protein 1 CP-1 -Homo sapiens; See PMID 7556077
An11g04660	Title: similarity to hypothetical protein B8J22.100 - Neurospora crassa
An11g04670	Function: the QDE-3 protein from N. crassa is involved in the phenomenon of posttranscriptional gene silencing (PTGS), which occurs when a transgene is introduced into a cell. The QDE-3 protein may function in the DNA-DNA interaction between introduced transgenes or with an endogenous gene required for gene-silencing activation.; Remark: a putative sequencing error results in an frameshift.; Similarity: the ORF encoded protein and the N. crassa QDE-3 protein belong to the RecQ DNA helicase family.; Title: strong similarity to DNA helicase QDE-3 -Neurospora crassa [putative frameshift]; nucleus; putative frameshift; See PMID 10600745
An11g04680	Function: the dynein heavy chain alpha Oda11 from C. reinhardtii is the force generating protein of eukaryotic cilia and flagella. It produces force towards the minus ends of microtubules. Dynein has ATPase activity.; Remark: C-terminally truncated ORF due to the end of contig.; Similarity: the ORF encoded protein shows strong similarity to the proteins of unknown function BAB09450. 1 (A. thaliana) and YPL263c/Kel3 (S. cerevisiae).; Title: similarity to dynein heavy chain alpha Oda11 - Chlamydomonas reinhardtii [truncated ORF]; See PMID 9725897
An11g04690	Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Kel3: YPL263c.; Similarity: the similarities of the ORF encoded protein to all matching proteins with an e-val less than 8e-13 are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein Kel3 - Saccharomyces cerevisiae [truncated ORF]
An11g04700	Catalytic activity: pyridoxine + NADP(+) <=> pyridoxal + NADPH.; Remark: alternate names for the S. pombe pyridoxine 4-dehydrogenase PLR : pyridoxal reductase; pyridoxin dehydrogenase; pyridoxine:NADP+ 4-oxidoreductase.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489
An11g04710	Similarity: the ORF encoded protein shows significant domain homology to the transcriptional regulator UaY from Emericella nidulans and to other fungal transcription factors.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421
An11g04720	Catalytic activity: dihydroxy- L-phenylalanine (DOPA) <=> dopamine + CO(2).; Cofactor: Pyridoxal-phosphate.; Title: strong similarity to aromatic amino acid decarboxylase Ddc - Sorangium cellulosum; See PMID 10816050
An11g04730	Function: the prolyl aminopeptidase PAP from Aeromonas sobria catalyzes release of a N-terminal proline from a peptide. The purified enzyme showed an almost absolute specificity for amino-terminal proline. Proline and hydroxyproline residues from many peptide and amide substrates could be easily removed, while no activity was detected for substrates having other amino terminals.; Gene-ID: papA; Remark: the matched sequence of papA from A. niger is identified by BLASTP against the new EMBL entry CAC40647.; Similarity: the prolyl aminopeptidase PAP from Aeromonas sobria belongs to peptidase family S33.
An11g04740	Similarity: the ORF encoded protein shows also a significant similarity hypothetical protein 'Sand' from Fugu rubripes.; Title: strong similarity to secreted protein SEQ ID NO:125 from patent WO200061624-A1 - Homo sapiens
An11g04750	Remark: mutant strains with a temperature-sensitive dopA allele or with a null deltadopA allele, show abnormal morphology of the vegetative hyphae, delayed and asynchronous initiation of asexual development, aberrant morphogenesis of the conidiophore and an early block in the sexual cycle.; Similarity: DopA (E. nidulans) homologues from S. cerevisiae (Dop1), Candida albicans, Caenorhabditis elegans, Rattus norvegicus and Homo sapiens have been identified from genome sequencing projects.; Title: strong similarity to developmental regulator of asexual and sexual reproduction dopA - Aspergillus nidulans; See PMID 10931277
An11g04760	Title: similarity to hypothetical protein EAA54961.1 - Magnaporthe grisea
An11g04770	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament protein NF-220 - Loligo pealei
An11g04780	Function: the Gup1 protein is essential for proton symport of glycerol into S. cerevisiae cells.; Remark: alternate name for S. cerevisiae Gup1: YGL084C.; Title: strong similarity to multimembrane-spanning protein involved in active glycerol uptake Gup1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10931309
An11g04790	Title: weak similarity to acylphosphatase Tu1 -Meleagris gallopavo
An11g04800	Title: questionable ORF
An11g04810	Function: the Aox1 enzyme from A. niger mediates cyanide-resistant oxygen consumption. It may increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.; Gene-ID: aox1; localisation:mitochondrion; See PMID 9933359
An11g04830	Title: strong similarity to hypothetical protein EAA64933.1 - Aspergillus nidulans
An11g04840	Function: MPR1 of S. cerevisiae sigma 1278b confers resistance to the L-proline analogue L-azetidine-2-carboxylic acid.; Function: MPR1 of S. cerevisiae sigma 1278b encodes a hypothetical N-acetyltransferase.; Title: strong similarity to L-proline-analogue resistance gene Mpr1 - Saccharomyces cerevisiae; See PMID 10894734
An11g04860	Similarity: to N6-DNA-methyltransferases in different organisms.; Title: similarity to hypothetical protein YDR140w -Saccharomyces cerevisiae
An11g04870	Remark: Sm-D exists in the cell as one of the core proteins of the small nuclear ribonucleoprotein complexes implicated in RNA processing.; Remark: the yeast homologue is associated with U1,U2, U4, U5, and U6 snRNA.; Similarity: to snRNA-associated proteins in different organisms.; Title: strong similarity to ribonucleoprotein autoantigen Sm-D - Homo sapiens; See PMID 11239461; See PMID 2528429; See PMID 3260384
An11g04880	Remark: only a small part of the protein shows this similarity.; Title: weak similarity to hypothetical novel nuclear protein NNP-1 var - Mus musculus
An11g04890	Remark: Rpn5 encodes a multicatalytic endopeptidase regulator involved in proteolysis and peptidolysis which is a component of the 19S proteasome regulatory particle.; Similarity: to sequences from Caenorhabditis elegans, Homo sapiens and S. cerevisiae.; Title: similarity to multicatalytic endopeptidase regulator Rpn5 - Drosophila melanogaster; See PMID 10893261
An11g04900	Remark: there is a weak similarity to extensin and polymerase like proteins cause of repetitiv elements of Serin and Prolin.
An11g04920	Remark: patent WO9907848-A1.; Remark: this polypeptide comprises the intracellular domain (residues 252-574) of human cytokine receptor 11 (Zcytor11), a novel class II cytokine receptor that appears to be a receptor for a helical cytokine of the interferon/interleukin-10 class.; Title: weak similarity to cytokine receptor 11 intracellular domain Zcytor11 from patent WO9907848-A1 -Homo sapiens
An11g04940	Catalytic activity: Acyl-CoA + O2 = trans-2,3-Dehydroacyl-CoA + H2O2.; Pathway: fatty acid metabolism.; Remark: the macrolide antibiotic tylosin is composed of a polyketide lactone substituted with three deoxyhexose sugars.; Title: similarity to acyl-CoA oxydase tylP -Streptomyces fradiae; See PMID 10220165; See PMID 10333459; See PMID 10467127
An11g04960	Title: weak similarity to hypothetical trans-activating transcription regulator tat - Human T-cell lymphotropic virus type 2
An11g04970	Title: weak similarity to immunodominant 45-55K antigen - Pneumocystis carinii
An11g04980	Remark: Yrb4p and Pse1p specifically bind to Gsp1p-GTP, protecting it from GTP hydrolysis and nucleotide exchange. The GTPase block of Gsp1p complexed to Yrb4p or Pse1p is released by Yrb1p, which contains a Gsp1p binding domain distinct from that of Yrb4p.; Remark: putative N-terminal truncated ORF due to end of contig.; Similarity: the yeast protein belongs to the RanBP7/importin-beta/Cse1p superfamily.; Title: similarity to RAN-binding protein Kap123 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9321403; See PMID 10078529
An11g04990	Remark: C-terminal truncated ORF due to end of contig.; Remark: Yrb4p and Pse1p specifically bind to Gsp1p-GTP, protecting it from GTP hydrolysis and nucleotide exchange. The GTPase block of Gsp1p complexed to Yrb4p or Pse1p is released by Yrb1p, which contains a Gsp1p binding domain distinct from that of Yrb4p.; Similarity: belongs to the RanBP7/importin-beta/Cse1p superfamily.; Title: similarity to RAN-binding protein Kap123 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9321403; See PMID 10078529
An11g05000	Remark: Niemann-Pick C (NPC) disease is a recessive cholesterol storage disorder characterized by severe,progressive neurodegeneration.; Remark: also strong similarity to Niemann-Pick C1 protein homologe S. cerevisiae patent WO9901555-A1.; Remark: subcellular localization studies have shown NPC1 to reside in late endosomes and to transiently associate with lysosomes and the trans-Golgi network.; Similarity: to yeast, worm and murine NPC1 proteins.; Title: strong similarity to Niemann-Pick C1 protein - Homo sapiens; See PMID 11001808; See PMID 10425213
An11g05010	Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein.; Remark: ayk1 is specifically expressed in meiotically active cells, and during spermatogenesis, ayk1 transcripts accumulate just before the first meiotic division.; Similarity: to IPL1 and aurora related kinases.; Title: strong similarity to protein kinase ayk1 -Xenopus laevis; deleted EC_number 2.7.1.37; See PMID 9205101
An11g05030	Similarity: has weak similarity to a hypothetical disease resistance protein from A. thaliana; Title: strong similarity to hypothetical protein encoded by An01g07930 - Aspergillus niger
An11g05050	Title: weak similarity to hypothetical protein APE0804 - Aeropyrum pernix
An11g05060	Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of the trichothecene T-2 toxin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Remark: trichothecenes are sesquiterpene epoxide mycotoxins produced by species of Fusarium, Trichothecium,and Myrothecium and act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973
An11g05080	Similarity: shows some similarity to N-terminal half of Atp7p of S. cerevisiae.; Title: weak similarity to H+-transporting ATP synthase chain d Atp7 - Saccharomyces cerevisiae
An11g05100	Similarity: shows match against EST (EMBLEST:AN791) of A. niger.; Similarity: the ORF encoded protein shows also weak similarity to protein kinase 6 from Glycine max.; Title: strong similarity to hypothetical protein encoded by An07g04880 - Aspergillus niger
An11g05110	Remark: protein contains both protein kinase domain (N-terminal) and ankyrin repeats (C-terminal part).; Similarity: shows similarity to N-terminal part of human DAPK1.; Title: similarity to death-associated protein kinase DAPK1 - Homo sapiens
An11g05120	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein T16H5. 30 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein T16H5.30 - Arabidopsis thaliana
An11g05130	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: NahG from P. stutzeri is a flavoprotein monooxygenase that catalyzes the conversion of salicylate to catechol.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Remark: the nahG gene of P. stutzeri is induced and expressed upon incubation with salicylate, the geneproduct is involved in naphthalene and salicylate metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; See PMID 10713446
An11g05140	Similarity: shows similarity to N-terminal part of nodulation protein B from Rhizobium sp.; Title: weak similarity to nodulation protein B -Rhizobium sp.
An11g05160	Similarity: weak similarity to homeotic protein Hox C5 from H. sapiens.; Title: weak similarity to homeotic protein Hox C5 -Homo sapiens
An11g05180	Title: strong similarity to lovF gene expression regulator At286 from patent WO200257456-A2 - Unclassified organism
An11g05190	Similarity: shows similarity to N-terminal part of guaA of E. coli.; Title: weak similarity to glutamine-hydrolyzing GMP synthase guaA - Escherichia coli
An11g05200	Remark: questionable ORF due to genestructure.; Title: questionable ORF
An11g05220	Remark: questionable ORF due to genestructure.; Title: questionable ORF
An11g05230	Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa
An11g05240	Complex: the anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).; Function: the APC2 gene is essential in S. cerevisiae, and yeast apc2 mutants arrest at metaphase and are defective in the degradation of Pds1p. APC2 and cullins may be distantly related members of a ubiquitin ligase family that targets cell cycle regulators for degradation.; Similarity: human APC2 contains a region that is similar to a sequence in cullins, a family of proteins implicated in the ubiquitination of G1 phase cyclins and cyclin-dependent kinase inhibitors.; Title: strong similarity to anaphase-promoting complex subunit 2 APC2 - Homo sapiens
An11g05260	Remark: a splice site was detected upstream of the START codon.; Remark: the systematic gene name of S. cerevisiae PKR1 is YMR123W.; Title: strong similarity to Pichia farinosa killer toxin resistance protein Pkr1 - Saccharomyces cerevisiae
An11g05280	Similarity: shows strong similarity to several known and hypothetical sugar transporters.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane
An11g05300	Remark: putative pseudogene, since several in frame STOP codons are present.; Title: strong similarity to transposase of transposable element Tan1 - Aspergillus niger [putative pseudogene]; putative pseudogene
An11g05310	Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in A. nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360; See PMID 10788322
An11g05320	Complex: teh mediator complex is a subcomplex of the RNA polymerase II holoenzyme.; Complex: the S. cerevisiae mediator complex can be dissociated into two stable subcomplexes: the Rgr1-associated subcomplex: Rgr1p, Gal11p, Sin4p,Med3p/Pgd1p, Srb7p, Med1p, Med4p, Med7p, Med8p, Med9p; the Med6-containing subcomplex: Srb4p, Srb2p, Srb5p, Srb6p,Med6p, Rox3p.; Remark: the systematic genename of S. cerevisiae YOL135c is MED7.; Title: strong similarity to mediator complex subunit Med7 - Saccharomyces cerevisiae; nucleus; See PMID 9420330
An11g05330	Function: DGPP phosphatase Dpp1p of S. cerevisiae is a membrane-associated 34-kDa enzyme which catalyzes the dephosphorylation of DGPP to yield phosphatidate (PA) and then catalyzes the dephosphorylation of PA to yield diacylglycerol.; Title: strong similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 11016943; See PMID 11139591
An11g05340	Function: amadoriase (fructosyl amine oxygen oxidoreductase) is an enzyme catalyzing the oxidative deglycation of Amadori products to yield corresponding amino acids, glucosone, and H2O2.; Similarity: almost identical to Aspergillus fumigatus protein.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus
An11g05350	Similarity: shows also similarity to Opt1p of S. cerevisiae.; Similarity: shows similarity to yeast and other eukaryotic isp4 proteins involved in sexual differentiation processes.; Title: similarity to oligopeptide transporter OPT1 -Candida albicans
An11g05380	Similarity: only N-terminal half shows similarity to transcriptional activators.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus
An11g05390	Similarity: only C-terminal part shows some similarity to C-terminal part of the Synechocystis ORF.; Title: similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis
An11g05400	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein YOR197w from S. cerevisiae.; Title: weak similarity to metacaspase casA -Aspergillus nidulans
An11g05410	Title: weak similarity to hypothetical protein yddE - Bacillus subtilis
An11g05420	Similarity: only C-terminal part shows some similarity to C-terminal part of the Synechocystis ORF.; Title: similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis
An11g05430	Title: similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger
An11g05440	Title: strong similarity to hypothetical protein MUTT - Arabidopsis thaliana
An11g05460	Function: F-actin capping proteins bind to the fast growing ends of F-actin thereby blocking subunit exchange at these ends.; Remark: truncated due to end of contig.; Title: strong similarity to F-actin capping protein alpha-1 subunit CapZ - Mus musculus [truncated ORF]; cytoskeleton
An11g05470	Remark: C-terminally truncated due to end of contig.; Title: strong similarity to hypothetical protein encoded by An15g04790 - Aspergillus niger [truncated ORF]
An11g05480	Title: similarity to hypothetical isoflavone reductase-like NAD(P)H-dependent oxidoreductase IRL1 -Medicago sativa
An11g05500	Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Cofactor: contains a covalently bound phosphopantetheine; Function: lys1 from S. pombe catalyses the sixth step in lysine biosynthesis.; Function: lys1 from S. pombe catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Title: similarity to aminoadipate-semialdehyde dehydrogenase lys1p - Schizosaccharomyces pombe
An11g05510	Alternative name: FK506/rapamycin-binding protein FPR3; immunophilin FKBP-70; proline rotamase; prolyl cis-trans isomerase NPI46; protein YML074c.; Catalytic activity: peptidyl-prolyl cis-trans isomerases catalyze the conversion of cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: strong similarity to peptidyl-prolyl isomerase Fpr3 - Saccharomyces cerevisiae; nucleus
An11g05520	Function: the Ustilago homologe plays a role in morphogenesis.; Title: similarity to serine/threonine protein kinase Ukc1p - Ustilago maydis
An11g05530	Alternative name: the systematic gene name of TAFII145 of S. cerevisiae is YGR274c.; Similarity: the N-terminal 220 amino acids of the predicted ORF are not aligned.; Title: strong similarity to subunit of transcription initiation factor TFIID Tafii145 - Saccharomyces cerevisiae; nucleus; See PMID 7667272
An11g05550	Similarity: shows similarity to several hypothetical major facilitator transporter homologs of different organisms.; Title: similarity to hypothetical major facilitator transporter Mfs1.1 - Coprinus cinereus; plasma membrane
An11g05560	Catalytic activity: 8-Amino-7-oxononanoate synthases catalyze the conversion of 6-Carboxyhexanoyl-CoA + L-Alanine = 8-Amino-7-oxononanoate + CoA + CO2; Pathway: 8-Amino-7-oxononanoate synthases are involved in the biotin biosynthesis.; Title: similarity to 8-amino-7-oxononanoate synthase bioF - Bacillus sphaericus; See PMID 1575677
An11g05570	Function: the Gibberella polyketide synthase is required for fumonisin biosynthesis.; Similarity: shows similarity to several polyketide synthases with different specificities.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis
An11g05580	Catalytic activity: glucose oxidases catalyze the conversion of beta-D-Glucose + O(2) = D-Glucono-1,5-Lactone + H(2)O(2).; Title: strong similarity to glucose oxidase GOD -Penicillium amagasakiense
An11g05600	Similarity: shows similarity to different dehydrogenases.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas oleovorans; See PMID 1542121
An11g05630	Title: strong similarity to hypothetical protein encoded by An11g09250 - Aspergillus niger
An11g05640	Title: strong similarity to hypothetical methyltransferase SPAC2G11.15C - Schizosaccharomyces pombe
An11g05650	Function: mammalian GRASP65 appears to function in the postmitotic reassembly of Golgi stacks.; Function: the mammalian peripheral golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and cdc2.; Golgi; Title: similarity to golgi peripheral membrane protein p65 GRASP65 - Rattus norvegicus; See PMID 9346242
An11g05660	Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens
An11g05680	Function: cytochrome P450s are involved in the oxidative degradation of various compounds. Particularly well known for their role in the degradation of environmental toxins and mutagens.; Title: similarity to cytochrome P450 3A13 - Mus musculus
An11g05690	Similarity: shows similarity to several alpha subunit of dinitrogenase reductases of unidentified nitrogen-fixing bacteria.; Title: similarity to hypothetical alpha subunit of dinitrogenase reductase nifH - Unclassified organism
An11g05700	Title: similarity to hypothetical membrane protein YGR235c - Saccharomyces cerevisiae
An11g05710	Function: Oct1p of S. cerevisiae is part of mitochondrial protein import machinery component involved in the biogenesis of the oxidative phosphorylation system.; Title: strong similarity to mitochondrial intermediate peptidase Oct1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10332043
An11g05720	Remark: Blast similarities found to salivary proteins (mucine) from Drosophila melanogaster due to threonine stretches.
An11g05730	Title: strong similarity to polypeptide SEQ ID NO:40167 from patent WO200171042-A2 - Drosophila melanogaster
An11g05740	Remark: similarity partially corresponds to serine repeats.; Title: weak similarity to hypothetical translation initiation factor SPAC17C9.03 - Schizosaccharomyces pombe
An11g05750	Function: the phosphotyrosyl phosphatase activator Rrd1p of S. cerevisiae functions with Cla4p to regulate the G(2)/M transition.; Title: similarity to phosphotyrosyl phosphatase activator Rrd1 - Saccharomyces cerevisiae; See PMID 10660069; See PMID 11134337
An11g05760	Title: strong similarity to hypothetical protein SPBC18H10.10c - Schizosaccharomyces pombe
An11g05780	Remark: blastp matches are due to repetitive seuqences.
An11g05800	Title: similarity to gene expression regulator Pc34 from patent WO200257456-A2 - Unclassified organism
An11g05810	Function: 2,4'-dihydroxyacetophenone dioxygenase catalyzes the conversion of 2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate.; Title: similarity to 2,4-dihydroxyacetophenone dioxygenase dad - Alcaligenes sp.; See PMID 10567221
An11g05820	Title: weak similarity to hypothetical transcription regulator, binuclear cluster zinc-finger protein SPBC1773.12 - Schizosaccharomyces pombe
An11g05840	Similarity: shows similarity to several probable short chain dehydrogenase proteins of different species.; Title: strong similarity to hypothetical short chain dehydrogenase L3377.10 - Leishmania major
An11g05850	Similarity: shows similarity to several oxidases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans
An11g05860	Remark: chi1 from E. dispar belongs to class 2 chitinases.; Similarity: shows similarity around the chitinase motif to several chitinases.; Title: similarity to chitinase cht1 - Entamoeba dispar; See PMID 9106188
An11g05870	Title: strong similarity to hypothetical protein encoded by An04g04580 - Aspergillus niger
An11g05880	Remark: C-terminally truncated due to contig end.; Title: strong similarity to hypothetical protein encoded by An12g03050 - Aspergillus niger [truncated ORF]
An11g05900	Remark: patent WO9831800-A2.; Title: weak similarity to BEF from patent WO9831800-A2 - Homo sapiens
An11g05910	Remark: LovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An11g05920	Catalytic activity: hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl- hydroxyproline analogs. No action on Pro-|-Pro.; Remark: homology was seen with the yeast hypothetical protein YJL213w.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239
An11g05930	Remark: DAL5 encodes a component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10943556; See PMID 3275614
An11g05940	Catalytic activity: 6 Malonyl-CoA + Propanoyl-CoA = 7 CoA + 6-Deoxyerythronolide b.; Remark: PKS1 is a multifunctional polyketide synthase (PKS) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: PKS1 is involved in production of the virulence factor T-toxin.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Similarity: shows also strong similarity to lovF Aspergillus terreus.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 10334994; See PMID 8953776
An11g05950	Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Remark: the protein shows similarity to one unknown protein of the Aspergillus terreus lovastatin biosynthesis gene cluster but seems to long.; Remark: the similarity to the dfr1 is only in the N-terminal part of the protein.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 10334994; See PMID 8088538
An11g05960	Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Remark: the lovF gene encodes an enzyme that is responsible for the biosynthesis of the (2R)-2-methylbutyryl side chain of lovastatin.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994
An11g05970	Remark: the protein shows similarity only with the C-terminal region of lysozyme2.; Title: weak similarity to muramidase-2 -Enterococcus hirae; See PMID 1347040
An11g05980	Remark: also similarity to ankyrin PBmAnk302 patent US5824306-A.; Title: weak similarity to protein encoded by clone CTONG20183430 from patent EP1308459-A2 - Homo sapiens
An11g06000	Remark: SRPK1 specifically induces the disassembly of nuclear speckles, and a high level of SRPK1 inhibits splicing in vitro.; Remark: the sequenz shows also similarity to the Human protein kinase hYAK3-alpha patent EP870825-A1.; Remark: the serine protein kinase SRPK1 from human is aproximately 250 aa longer.; Title: similarity to serine protein kinase SRPK1 -Homo sapiens; See PMID 8208298
An11g06030	Remark: the protein shows also similarity to ankyrin like proteins in the N-terminal part.; Title: weak similarity to protein CGDD-16 from patent WO2002102310-A2 - Homo sapiens
An11g06040	Catalytic activity: ATP + Choline = ADP + Choline phosphate.; Pathway: glycerolipid metabolism.; Remark: choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway.; Remark: the sequence shows similarity to a wide range of choline kinases in different organisms.; Title: similarity to choline kinase CK1 - Glycine max; See PMID 8934624
An11g06060	Remark: ankyrin participates in signal transduction and in assembly of integral membrane proteins.; Remark: ankyrins are linker proteins, which connect various membrane proteins, including members of the L1 family of neural cell adhesion molecules, with the submembranous actin-spectrin skeleton.; Remark: expression of Dank2 is restricted to the nervous system in the Drosophila embryo.; Title: strong similarity to ankyrin 2 Ank2 -Drosophila melanogaster; See PMID 10844021; See PMID 11018513
An11g06080	Catalytic activity: beta-glucosidases hydrolyse terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Title: strong similarity to beta-glucosidase 1 bgl1 - Aspergillus aculeatus [truncated ORF]; extracellular/secretion proteins; See PMID 9757570; See PMID 8964516
An11g06090	Catalytic activity: Hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Title: strong similarity to beta-glucosidase2 BGL2 -Saccharomycopsis fibuligera; See PMID 3146949
An11g06100	Similarity: the ORF encoded protein shows also in a distinct regionweak similarity to putative serine /threonin protein kinase Ca20C1. 20 from Candida albicans.; Title: similarity to hypothetical protein encoded by An15g02090 - Aspergillus niger
An11g06110	Catalytic activity: Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.; Title: similarity to purine-nucleoside phosphorylase punA - Bacillus stearothermophilus; See PMID 9058965
An11g06120	Catalytic activity: 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.; Title: strong similarity to decarboxylating phosphogluconate dehydrogenase - Medicago sativa; See PMID 7640360
An11g06130	Title: strong similarity to hypothetical 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa
An11g06140	Catalytic activity: 1-pyrroline-5-carboxylate + Nad(+) + H(2)O = l-glutamate + NadH.; Function: p5cdh of H. sapiens catalyzes the irreversible conversion of delta-1-pyrroline-5-carboxylate (p5c), derived either from proline or ornithine, to glutamate which is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles.; Pathway: second step in the conversion of proline to glutamate.; Remark: the preferred substrate of p5cdh is glutamic gamma-semialdehyde, other substrates include succinic,glutaric and adipic semialdehydes.; Title: strong similarity to delta-1-pyrroline-5-carboxylate dehydrogenase p5cdh - Homo sapiens; localisation:mitochondrion; See PMID 8621661
An11g06150	Remark: as ORF 70WG on the same contig encodes the A. niger prnA homolog, it is assumed, that the region consists of a proline utilisation gene cluster, important for the utilization of proline as sole nitrogen and/or carbon source.; Remark: prnB of A. nidulans encodes the major proline transport system and is part of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8437566; See PMID 9140969; See PMID 10613888
An11g06160	Title: strong similarity to proline oxidase prnD -Aspergillus nidulans; localisation:mitochondrion; See PMID 355839; See PMID 9184237
An11g06170	Alternative name: THBP; Function: Crym of H. sapiens binds thyroid hormone and is presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.; Similarity: Crym of H. sapiens is similar to bacterial ornithine cyclodeaminases.; Title: similarity to thyroid hormone-binding protein mu-crystallin Crym - Homo sapiens; cytoplasm; See PMID 9328354; See PMID 1384048
An11g06180	Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 622360
An11g06190	Remark: Nucleolin induces chromatin decondensation by binding to histone h1 and is thought to play a role in pre-rrna transcription and ribosome assembly.; Remark: Nucleolin is the major nucleolar protein of growing eukaryotic cells and is found associated with intranucleolar chromatin and preribosomal particles.; Title: similarity to nucleolin protein C23 - Homo sapiens; nucleus
An11g06200	Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol.; Title: strong similarity to 31 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2145832; See PMID 2142943
An11g06210	Alternative name: MOT2; Remark: S. cerevisiae Mot2 gene encodes a putative zinc finger protein that negatively regulates several categories of genes, including mating-pheromone-responsive genes.; Title: strong similarity to zinc-finger protein Sig1 - Saccharomyces cerevisiae; nucleus; See PMID 8039500; See PMID 8164669; See PMID 8164670
An11g06230	Remark: Patentmatch against protein AC AX065577_1 Tremblnew.; Title: similarity to oxidoreductase from patent WO0100844 - Corynebacterium glutamicum
An11g06240	Title: weak similarity to kinetochore protein CENP-F - Homo sapiens; See PMID 7542657
An11g06250	Similarity: a short stretch of amino acids shows some similarity to a D. melanogaster hypothetical ORF; the structure of the gene model remains questionable.; Title: questionable ORF
An11g06260	Function: pentalenene synthase of Streptomyces is a terpenoid cyclase; the similarity of the predicted ORF is to weak to allow any conclusion about its function.; Title: weak similarity to pentalenene synthase -Streptomyces sp.; See PMID 8180213; See PMID 9295272
An11g06270	Catalytic activity: GfCPS/KS of G. fujikuroi converts geranylgeranyl diphosphate to copalyl diphosphate and ent-kaurene.; Pathway: terpenoid biosynthesis.; Similarity: the C-terminal part of GfCPS/KS of G. fujikuroi is not conserved in the predicted ORF.; Title: strong similarity to Ent-Kaurene synthase GfCPS/KS - Gibberella fujikuroi; See PMID 10644675; See PMID 10803977
An11g06280	Remark: the patented entry is an amino acid sequence conceptually translated from a DNA sequence.; Title: strong similarity to protein fragment SEQ ID NO:17197 from patent EP1033405 - Arabidopsis thaliana
An11g06290	Function: the transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in A. niger.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Title: strong similarity to transcription activator xlnR - Aspergillus niger; nucleus; See PMID 9466262; See PMID 9758775; See PMID 10376490; See PMID 10508057; See PMID 10760176
An11g06300	Title: strong similarity to hypothetical protein AAO76091.1 - Bacteroides thetaiotaomicron
An11g06320	Function: rhamnogalacturonases allow A. niger to use plant pectins as carbon source.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Similarity: the predicted ORF shows equally strong similarity to both rhgA and rhgB genes, encoding the two known isoforms of rhamnogalacturonase of A. niger.; Similarity: the size of the predicted ORF suggested to use rhgA for the annotation.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus niger; See PMID 7576553; See PMID 9212401
An11g06330	Remark: in A. niger three alpha-galactosidases has already been characterized and named aglA, aglB, and aglC.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Similarity: also P. simplicissimum produces at least three different alpha-galactosidases, which substrate specificities are different and well studied.; Similarity: the predicted ORF is also very similar,but not identical to alpha-galactosidase aglB of A. niger.; Title: strong similarity to alpha-galactosidase 1 agl1 - Penicillium simplicissimum; See PMID 9463945; See PMID 9756469; See PMID 10347026
An11g06350	Catalytic activity: release of a C-terminal amino acid with a broad specificity.; Function: cpy1 of S. pombe digests preferentially peptides containing an aliphatic or hydrophobic residue in p1' position, as well as methionine, leucine or phenylalanine in p1 position of ester substrate.; Function: cpy1 of S. pombe is involved in degradation of small peptides.; Localization: cpy1 of S. pombe is found in lysosome-like vacuoles.; Remark: carboxypeptidase C of S. pombe is also called carboxypeptidase Y, and the gene has the alternative names cpy1 or SPAC19G12. 10c.; Similarity: cpy1 of S. pombe belongs to peptidase family S10; also known as the serine carboxypeptidase family.; Similarity: the N-terminal part of cpy1 of S. pombe is not conserved in the predicted ORF; due to the vicinity of a retrotransposable element, it is possible to hypothesize that a portion of the gene went destroied due to the transposition event.; Title: strong similarity to carboxypeptidase C cpy1p - Schizosaccharomyces pombe; See PMID 9209031
An11g06380	Title: strong similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum
An11g06400	Title: weak similarity to hypothetical protein encoded by An04g07900 - Aspergillus niger
An11g06410	Remark: SED4 of S. cerevisiae is also known as YCR067C.; Title: weak similarity to ER membrane protein Sed4 -Saccharomyces cerevisiae; See PMID 11168590; See PMID 7593162; See PMID 7865879; See PMID 1327759; See PMID 9880808
An11g06420	Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity also to ORF10 (metabolite transport protein),patentnumber WO200037629, belonging to the lovastatin gene cluster of A. terreus; note that other ORFs with similarity to members of this cluster where found on contig cmln. 00 (and namely 70cg, 80wg and 90cg).; Similarity: the predicted ORF shows strong similarity to several hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum; See PMID 10334994
An11g06430	Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 11391010
An11g06440	Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what observed for the predicted ORFs cmln. 00. tfa_70cg, 80wg and 90cg.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An11g06450	Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what is observed for the predicted ORF.; Similarity: EST EMBLEST:BE760262 covers part of the last exon and of the putative 3'-UTR of the predicted gene.; Similarity: the ORF encoded protein shows also strong similarity to EST EMBLEST Acc. N. : BE760262 from Aspergillus niger.; Title: strong similarity to hypothetical protein encoded by An02g08300 - Aspergillus niger
An11g06460	Function: like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.; Function: many polyketides are antibiotics.; Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Function: whereas the intermediates in fatty acid biosynthesis are fully reduced to generate unfunctionalized alkyl chains, the intermediates in polyketide biosynthesis may be only partially processed, giving rise to complex patterns of functional groups.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what observed for the predicted ORFs cmln. 00. tfa_70cg, 80wg and 90cg.; Remark: polyketide synthases are commercially valuable enzyme.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 10872449
An11g06480	Title: weak similarity to antigenic protein f86.aa from patent WO9859071 - Borrelia burgdorferi
An11g06490	Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa
An11g06510	Catalytic activity: chnB of Acinetobacter catalyzes the reaction: cyclohexanone + NADPH + O2 = 6-hexanolide + NADP+ + H2O.; Function: chnB of Acinetobacter is the key enzyme in the cyclohexanone oxidation pathway.; Similarity: the predicted ORF shows strong similarity to many hypothetical and known monooxygenases.; Title: strong similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 2177829; See PMID 3338974; See PMID 10543838
An11g06520	Similarity: the similarity to nucleolin and other proteins is due almost exclusively to these repetitive units.; Title: weak similarity to protein SEQ ID NO:141 from patent WO200025728-A2 - Plasmodium falciparum
An11g06530	Similarity: the predicted ORF shows weak similarity to many env retroviral proteins; it might represent the remnant of a retrotransposition event.; Title: weak similarity to envelope glycoprotein env - Human immunodeficiency virus type 1; See PMID 10381169
An11g06540	Gene-ID: mndA; Remark: these observations suggest that, besides the hypothetical existence of a gene duplication, the differences with the A. niger MndA could be explained also by sequencing errors in the published sequence.; Similarity: in the region where the differences to the A. niger MndA exist, the predicted ORF is nearly identical to the beta-mannosidase (manB) gene of the related species A. aculeatus.; Similarity: the current DNA sequence was verified also on contig caoc. 00, that has an overlap to this region; no difference exists between the present contig cmln. 00 and contig caoc. 00.; Similarity: the differences of the predicted ORF to A. niger MndA, in the N-terminal region, are due to single nucleotide mismatches causing frameshifts.; See PMID 11358516
An11g06560	Title: questionable ORF
An11g06570	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 10974123; See PMID 7557402; See PMID 9435787; See PMID 10875280
An11g06580	Function: Clk2 of M. musculus is a protein kinase constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing.; Remark: Phosphorylated serine- and arginine-rich (SR) proteins are components of the spliceosomal complex,and have been implicated in the control of alternative splicing.; Similarity: the presence of a ribosomal protein pattern in the N-terminal part of the predicted ORF may suggest possible interactions with RNA.; Similarity: the similarity of the predicted ORF to Clk2 of M. musculus involves only the C-terminal half of the protein.; Title: similarity to cdc2/CDC28-like kinase 2 Clk2 -Mus musculus; deleted EC_number 2.7.1.37; See PMID 9307018
An11g06590	Function: COQ5 of S. cerevisiae is a 2-methoxy-6-polyprenyl-1,4-benzoquinone methyltransferase,involved in the biosynthesis of ubiquinone.; Remark: COQ5 of S. cerevisiae is also known as YML110c, DBI56, or TCM7.; Title: strong similarity to methyltransferase Coq5 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9083048; See PMID 9083049; See PMID 9873020
An11g06600	Title: strong similarity to polysialic acid capsule expression protein kpsF - Escherichia coli; See PMID 9383150
An11g06610	Catalytic activity: ATP + nicotinamide ribonucleotide <=> diphosphate + NAD(+).; Pathway: the human nicotinamide mononucleotide adenylyl transferase NMNAT is involved in the nicotinate and nicotinamide metabolism.; Similarity: the ORF encoded protein also shows strong similarity to the essential E. nidulans protein AN85 from patent WO9924580-A2, which is not precisely enough decribed.; Title: strong similarity to nicotinamide mononucleotide adenylyl transferase NMNAT - Homo sapiens; nucleus; See PMID 11248244
An11g06630	Catalytic activity: ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Remark: S. cerevisiae Ufd4p directly interacts with the 26S proteasome.; Remark: alternate name for S. cerevisiae Ufd4: YKL010C.; Title: strong similarity to ubiquitin protein ligase Ufd4 - Saccharomyces cerevisiae; See PMID 7615550; See PMID 10688918
An11g06640	Title: similarity to hypothetical protein SPBC26H8.11c - Schizosaccharomyces pombe
An11g06650	Function: S. cerevisiae Rrp3 is required for pre-ribosomal RNA processing. It is involved in the maturation of the 35s-pre-rRNA and to its cleavage to mature 18s rRNA.; Remark: alternate name for S. cerevisiae Rrp3: YHR065C.; Similarity: the ORF encoded protein also shows strong similarity to the putative S. cerevisiae RNA helicase Mak5 and to the human ATP-dependent RNA helicase from patent US5888792-A, but their functions are not precisely enough decribed.; Title: strong similarity to ATP dependent RNA helicase Rrp3 - Saccharomyces cerevisiae; nucleus; See PMID 8774901
An11g06660	Complex: coimmunoprecipitation experiments show that Spb1 is associated in vivo with the nucleolar proteins Nop1 and Nop5/58.; Function: Spb1p has been suggested to be a methyltransferase involved in rRNA formation. as AdoMet-dependent methyltransferases it is able to bind [(3)H]AdoMet in vitro.; Remark: alternate name for S. cerevisiae Spb1p: YCL054W.; Remark: if the spb1-2 mutant S. cerevisiae strain has been grown at the restrictive temperature, the processing of the 27S pre-rRNA into mature 25S rRNA and 5. 8S is completely abolished and production of mature 18S is reduced, while the abnormal 23S species is accumulated. the mutant also shows a reduced 60S ribosomal subunit content.; Title: strong similarity to methyltransferase required for 60S ribosomal subunit biogenesis Spb1 -Saccharomyces cerevisiae; nucleus; See PMID 10556316; See PMID 10648622
An11g06670	Catalytic activity: H(2)S + 3 NADP(+) + 3 H(2)O <=> sulfite + 3 NADPH.; Cofactor: FMN,FAD.; Function: S. cerevisiae Met10 is a enzyme that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.; Pathway: Met10 catalyzes the fourth step in the sulfate assimilation pathway that leads to the biosynthesis of methionin and cysteine.; Remark: alternate name for S. cerevisiae Met10: YFR030W.; Title: strong similarity to alpha subunit of assimilatory sulfite reductase Met10 - Saccharomyces cerevisiae; See PMID 7928966; See PMID 9634827
An11g06680	Complex: the TIP30 protein interacts with Tat and with an SRB-containing RNA polymerase II complex both in vivo and in vitro.; Function: the human TIP30 protein is a cofactor that specifically enhances human immunodeficiency virus-1 (HIV-1) Tat-activated transcription.; Similarity: TIP30 (also named CC3) is a member of the short-chain dehydrogenases/reductases (SDR) family.; Title: strong similarity to Tat-interacting protein TIP30 - Homo sapiens; nucleus; See PMID 10892349; See PMID 9482853
An11g06690	Title: weak similarity to cytoplasmic protein encore enc - Drosophila melanogaster
An11g06720	Function: the S. cerevisiae Pre9p protein is a subunit of the yeast proteasome. The proteasome is a multicatalytic proteinase complex which catalyzes the degradation of peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.; Remark: alternate gene names for S. cerevisiae Pre9: PRS5, Y13 or YGR135W.; Title: strong similarity to proteasome 20S subunit Pre9 - Saccharomyces cerevisiae; See PMID 9087403; See PMID 1898763
An11g06730	Complex: CA150 was found to bind to the hyperphosphorylated CTD of the actively transcribing RNA polymerase II (Pol II).; Function: the human CA150 protein is a cellular cofactor of Tat-mediated transcriptional activation. It is involved in regulation of RNA polymerase II mediated transcriptional elongation.; Remark: the Tat protein is a strong transcriptional activator from the human immunodeficiency virus type 1 (HIV-1).; Title: similarity to transcription factor CA150 -Homo sapiens; nucleus; See PMID 10908677; See PMID 9315662; See PMID 10373521
An11g06740	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament subunit NF-180 - Petromyzon marinus
An11g06750	Similarity: the similarities of the ORF encoded protein to proteins matching with an e-Val less than 3e-19 are mainly based on repetitive structures.; Title: similarity to hypothetical protein SPCC645.13 - Schizosaccharomyces pombe
An11g06760	Complex: the U1 snRNP, cap-binding complex (CBC) and Luc7 are in one complex. Luc7 is required for coprecipitation of U1 snRNP with CBC.; Function: S. cerevisiae Luc7p is a component of yeast U1 snRNP and is essential for vegetative growth. the loss of Luc7p disrupts U1 snRNP-CBC interaction.; Remark: alternate name for S. cerevisiae Luc7: YDL087C.; Remark: the LUC7 gene was identified by a mutation that causes lethality in a yeast strain lacking the nuclear cap-binding complex (CBC).; Title: strong similarity to small nuclear ribonucleoprotein Luc7 - Saccharomyces cerevisiae; nucleus; See PMID 10500099
An11g06770	Similarity: the ORF encoded protein shows strongest similarity to hypothetical protein YHR188c from S. cerevisiae.; Title: strong similarity to skin cell protein from patent WO9955865-A1 - Rattus sp.
An11g06780	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to variable surface lipoprotein VlpD - Mycoplasma hyorhinis
An11g06790	Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to DEAH-box RNA helicase Mut6 - Chlamydomonas reinhardtii
An11g06800	Function: the S. cerevisiae Kar5/Fig3 protein is required for nuclear fusion.; Remark: alternate names for S. cerevisiae Kar5: Fig3 or YMR065W.; Title: similarity to protein involved in nuclear fusion Kar5 - Saccharomyces cerevisiae; See PMID 9382856; See PMID 9456310; See PMID 10069807
An11g06810	Remark: alternate name for S. cerevisiae MRPL6: YHR147C,YML6 or 60S ribosomal protein L6(mitochondrial).; Similarity: the S. cerevisiae MRPL6 protein belongs to the L6p family of ribosomal proteins.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8358820
An11g06820	Catalytic activity: adenosine 3',5'-bisphosphate + H(2)O <=> adenosine 5'-phosphate + phosphate.; Function: Met22 is a metabolic phosphatase which catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. This reaction is part of the sulfour metabolism.; Remark: alternate names for S. cerevisiae Met22 are Hal2, YOL064C or 3'(2'),5'-bisphosphate nucleotidase.; Similarity: the S. cerevisiae Met22 enzyme belongs to the family of sodium-sensitive phosphatase.; Title: strong similarity to salt tolerance protein Met22 - Saccharomyces cerevisiae; See PMID 8910555; See PMID 10656801
An11g06830	Title: strong similarity to hypothetical protein SPBC31F10.07 - Schizosaccharomyces pombe
An11g06840	Title: questionable ORF
An11g06850	Remark: CtHAL3 the C. tropicalis homolog gene of S. cerevisiae HAL3 partially complements the salt sensitivity of a S. cerevisiae hal3 mutant.; Similarity: the ORF encoded protein is also similar to the S. cerevisiae Hal3 (Sis2) protein: Pubmed 7565698.; Title: similarity to salt-tolerance protein HAL3 -Candida tropicalis; See PMID 8923737
An11g06860	Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234
An11g06870	Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to haploid specific alanine-rich acidic protein halap-X - Mus musculus
An11g06880	Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to h-caldesmon - Gallus gallus
An11g06890	Title: weak similarity to PDZ domain protein MUPP1 -Rattus norvegicus; See PMID 9537516
An11g06900	Function: S. cerevisiae UBC8 functions in catabolite degradation of fructose-1, 6-bisphosphatase.; Function: T. aestivum TaUBC4 is capable of binding ubiquitin by means of a thiol ester linkage in an ATP-dependent and ubiquitin-activating enzyme-dependent reaction.; Function: T. aestivum TaUBC4 specifically ubiquinates histones without the help of ubiquitin-protein ligases (E3s) and shows strong similarity to S. cerevisiae UBC8.; Title: strong similarity to ubiquitin conjugating enzyme TaUBC4 - Triticum aestivum; See PMID 2557633; See PMID 8155884; See PMID 10811607
An11g06920	Complex: S. cerevisiae Apg12 is conjugated to Apg5p.; Complex: S. cerevisiae Apg16p interacts with theApg12-Apg5p conjugate and mediates self-multimerization that leads to cross-linking of Apg5p molecules and formation of a stable protein complex.; Complex: conjugation of S. cerevisiae Apg12 to Apg5p requires Apg7 a ubiquitin-E1-like enzyme and Apg10, a specific ubiquitin-E2-like enzymes.; Function: S. cerevisiae Apg12 is a polypeptide that is used as tag to affect the function of Apg5.; Function: S. cerevisiae Apg12 was isolated in a screen for autophagy-defective (apg) mutants, a process for the bulk degradation of proteins, in which cytoplasmic components of the cell are enclosed by double-membrane structures known as autophagosomes for delivery to lysosomes or vacuoles for degradation.; Function: in mouse Apg12-Apg5 complex formation is essential for the involvement of Apg5 in elongation of the isolation membranes and for targeting of a mammalian Aut7/Apg8 homologue, LC3, to the isolation membranes.; Remark: the systematic name for S. cerevisiae Apg12 is YBR217w.; Title: strong similarity to autophagy modulator Agp12 - Saccharomyces cerevisiae; cytoplasm; See PMID 11100732; See PMID 11266458; See PMID 9759731; See PMID 10406794; See PMID 10608654
An11g06930	Catalytic activity: A. nidulans panB converts 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate to tetrahydrofolate + 2-dehydropantoate.; Function: A. nidulans panB is essential for the biosynthesis of coenzyme A, while the pathway intermediate 4'-phosphopantetheine is required for penicillin production.; Title: strong similarity to 3-methyl-2-oxobutanoate hydroxymethyltransferase panB - Aspergillus nidulans; See PMID 10503542
An11g06950	Function: A. nidulans nimO is required for initiation of DNA synthesis and for efficient progression through S phase.; Function: nimO18 mutants abrogated a cell cycle checkpoint linking S and M phases by segregating their unreplicated chromatin. this checkpoint defect did not interfere with other checkpoints monitoring spindle assembly and DNA damage (dimer lesions), but did prevent activation of a DNA replication checkpoint.; Similarity: A. nidulans nimO is related structurally and functionally to S. cerevisiae Dbf4p, the regulatory subunit of Cdc7p kinase and contains a C-terminal PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif.; Title: strong similarity to DNA synthesis and mitotic checkpoint control protein nimO - Aspergillus nidulans; See PMID 10194410
An11g06960	Complex: E. coli pepP forms a homotetramer.; Function: E. coli pepP is a proline specific aminopeptidase which releases any N-terminal amino acid that is linked to proline.; Remark: E. coli pepP is Zn2+ dependent.; Title: strong similarity to aminopeptidase II pepP -Escherichia coli; See PMID 2659585
An11g06970	Title: similarity to hypothetical protein Ta1372 -Thermoplasma acidophilum; See PMID 11029001
An11g06980	Function: human SIRT5 belongs to the Sir2-like proteins (sirtuins) and may metabolize NAD and have protein ADP-ribosyltransferase activity.; Function: yeast Sir2 protein regulates epigenetic gene silencing and as a possible antiaging effect it suppresses recombination of rDNA while cobB, a E. coli SIR2-like gene, seems to encode a pyridine nucleotide transferase.; Similarity: the predicted A. niger protein also shows similarity to lacR, the repressor of the lactose operon of S. aureus.; Title: similarity to sirtuin type 5 SIRT5 - Homo sapiens; See PMID 2163387; See PMID 10381378
An11g06990	Function: S. pombe Rhp16 is involved in the nucleotide excision repair of UV damage.; Function: S. pombe rhp7 or rhp16 deficient cells are, in contrast to S. cerevisiae rad7 and rad16 mutants, only sensitive to UV irradiation if the alternative repair mechanism, UV damage repair (UVDR) is absent.; Induction: S. pombe Rhp16 is UV-inducible.; Similarity: S. pombe Rhp16 contains two Zn-finger motifs and a putative helicase domain.; Title: similarity to UV damage nucleotide excision repair protein rph16p - Schizosaccharomyces pombe; nucleus; See PMID 8879272; See PMID 10446227
An11g07000	Function: S. fradiae aph phosphorylates, and thereby inactivates, the antibiotic neomycin.; Title: weak similarity to kanamycin kinase aph -Streptomyces fradiae; See PMID 2542127; See PMID 6310563
An11g07010	Catalytic activity: C. tropicalis alk2 was shown to hydroxylate hexadecane, but had no hydroxylation activity towards lauric acid.; Induction: C. tropicalis alk2 is induced by growth on alkane.; Localization: C. tropicalis alk2 contains only one transmembrane domain and its N-terminus is located in the ER lumen.; Similarity: C. tropicalis alk2 belongs to the CYP52 family and an alternative name is CYP52A2.; Title: strong similarity to alkane-inducible cytochrome P450 alk2 - Candida tropicalis; endoplasmatic reticulum; See PMID 8375386; See PMID 1937041
An11g07020	Similarity: the predicted A. niger protein shows strong similarity to several hyptothetical proteins derived from genome sequencing projects as well as to three A. niger ESTs, EMBLEST:BE759124, EMBLEST:BE759800 and EMBLEST:BE759798.; Title: similarity to hypothetical protein BAB52928.1 - Mesorhizobium loti
An11g07030	Function: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Function: it is suggested that M. grisea pth11p is not required for appressorium morphogenesis but is involved in host surface recognition.; Localization: a M. grisea Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Pathway: in M. grisea exogenous activation of cellular signaling suppressed pth11 defects.; Similarity: similarity is from the predicted A. niger protein to the central region of M. grisea pth11,which is 300aa longer.; Title: similarity to plasma membrane protein Pth11 -Magnaporthe grisea; See PMID 10521529
An11g07040	Similarity: the predicted A. niger protein shows strong similarity to 7 ESTs from A. niger, suggesting that it is a strongly expressed gene.; Title: strong similarity to EST an_2779 -Aspergillus niger
An11g07050	Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An11g07060	Title: weak similarity to actinomycin synthase III acmC - Streptomyces chrysomallus; See PMID 10780924
An11g07070	Complex: human SRPK2 bound unphosphorylated,cytoplasmic SF2/ASF but did not bind phosphorylated,nuclear SF2/ASF.; Function: human SRPK2 phosphorylates the Serine/arginine-rich (SR) family of splicing factors,mediating spliceosome assembly and the trafficking of splicing factors into the nucleus.; Title: similarity to SR protein-specific kinase SRPK2 - Homo sapiens; See PMID 9472028; See PMID 10196197
An11g07080	Title: strong similarity to hypothetical protein AAO78637.1 - Bacteroides thetaiotaomicron
An11g07090	Title: weak similarity to bacteriocin 2 LbnB2 from patent WO9723619-A1 - Lactobacillus amylovorus
An11g07100	Title: strong similarity to hypothetical protein encoded by An01g05280 - Aspergillus niger
An11g07110	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g07120	Function: the predicted A. niger protein shows weak similarity to several proteases with different specifities.; Title: strong similarity to glutamyl endoprotease polypeptide from patent WO200268623-A2 - Aspergillus niger
An11g07140	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein BAB11373. 1 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein encoded by An12g03730 - Aspergillus niger
An11g07150	Function: AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the central region of S. cerevisiae MSP1, which is 600 aa shorter.; Similarity: the predicted A. niger protein shows weak similarity to several AAA type ATPases.; Title: weak similarity to AAA family ATPase Msp1 -Saccharomyces cerevisiae; See PMID 8226973; See PMID 9695811
An11g07160	Title: weak similarity to hypothetical protein encoded by An16g05640 - Aspergillus niger
An11g07170	Function: it has been suggested that C. intestinalis CiGRP1 is a RNA-binding protein.; Localization: C. intestinalis CiGRP1 is found in all nuclei and in the cytoplasm.; Similarity: similarity is from the predicted A. niger protein to the glycine repeats of C. intestinalis CiGRP1, which is 80 aa longer.; Title: similarity to glycine rich putativly RNA-binding protein CiGRP1 - Ciona intestinalis; See PMID 10675629
An11g07180	Title: weak similarity to Uncoupling protein 2 Ucp2 - Danio rerio; See PMID 10524261
An11g07190	Catalytic activity: malate dehydrogenases convert (S)-malate + NAD(+) to oxaloacetate + NADH.; Function: malate dehydrogenases are involved in the tricarbolic-acid cycle of carbohydrate utilisation.; Title: strong similarity to mitochondrial malate dehydrogenase MDH - Mus musculus; localisation:mitochondrion; See PMID 3038184
An11g07200	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An11g07210	Complex: accumulation of ankyrin at cell contacts required the presence of the cytoplasmic domain of neuroglian activated by cell-cell contact.; Function: ankyrin links integral membrane proteins to the spectrin-based membrane skeleton.; Function: proteins containing ankyrin-repeats interact specifically with a diverse array of macromolecular targets and show an extraordinary variety of biological activities.; Similarity: similarity is from the C-terminal ankyrin-domain containing region of the predicted A. niger protein to the N-terminal half of D. melanogaster Ank.; Title: similarity to ankyrin Ank - Drosophila melanogaster; See PMID 10431175; See PMID 7937942
An11g07220	Similarity: the ORF encoded protein shows also weak similarity to adult male testis cDNA 4930511N22 from Mus musculus.; Title: strong similarity to hypothetical protein EAA64855.1 - Aspergillus nidulans
An11g07250	Title: strong similarity to reverse transcriptase pol - Volvox carteri; See PMID 7681411
An11g07270	Catalytic activity: D(--)-mandelate dehydrogenase catalyses the NAD(+)-dependent oxidation of D-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase D-MDH - Rhodotorula graminis; See PMID 1731758
An11g07280	Induction: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the C-terminal region of A. parasiticus hxtA, which is 300 aa longer.; Title: weak similarity to hexose transporter hxtA -Aspergillus parasiticus; See PMID 10978525
An11g07290	Catalytic activity: Streptomycin 3''-adenylyltransferases convert ATP + streptomycin to diphosphate + 3''-adenylylstreptomycin.; Function: S. aureus spc is a spectinomycin adenyltransferase that mediates resistance to spectinomycin but not to streptomycin and is part of Tn554, a IS-element.; Title: similarity to spectinomycin adenylyltransferase spc - Staphylococcus aureus; See PMID 2993813
An11g07300	Function: expression of C. albicans Flu1 mediated not only resistance to fluconazole but also to cycloheximide.; Remark: ORF 3'truncated due to end of contig.; Similarity: C. albicans Flu1 belongs to the major facilitator superfamily.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans [truncated ORF]; See PMID 11065353
An11g07310	Function: C. lagenarium PKS1 gene encodes a polyketide synthase involved in melanin biosynthesis.; Title: strong similarity to polyketide synthase PKS1 - Colletotrichum lagenarium; See PMID 7500937
An11g07320	Catalytic activity: glyoxylases II convert (S)-(2-hydroxyacyl)glutathione + H(2)O to glutathione + a 2-hydroxy acid anion.; Function: S. cerevisiae GLO2 is involved in amino acid catabolism.; Remark: the systematic name for S. cerevisiae GLO2 is YDR272W.; Title: similarity to glyoxalase II Glo2 -Saccharomyces cerevisiae; cytoplasm; See PMID 9261170
An11g07330	Complex: P. fluorescens 6-HNAMO is a flavoprotein binding FAD and depending on NADH.; Function: P. fluorescens 6-HNAMO is used for the industrial production of 2,5-dihydroxypyridine.; Similarity: the predicted A. niger ORF is identical to the A. niger EST an_1529, EMBLEST:BE760351.; Title: similarity to 6-hydroxynicotinic acid mono-oxygenase 6-HNAMO from patent JP09121864-A -Pseudomonas fluorescens; See PMID 10091591
An11g07340	Function: S. maritimus EncK is a putative O-methyl transferase implicated in enterocin polyketide biosynthesis.; Title: strong similarity to hypothetical O-methyl transferase EncK - Streptomyces maritimus; See PMID 11137817
An11g07350	Function: GABA utilization is amdR-dependent in A. oryzae.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; nucleus; See PMID 1452021
An11g07370	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An11g07380	Catalytic activity: P. fluorescens phzF catalyzes the hydroxylation of phenazine-1-carboxylic acid to 2-hydroxy-phenazine-1-carboxylic acid.; Function: P. fluorescens phzF is involved in the production of the broad-spectrum antibiotic phenazine-1-carboxylic acid (PCA).; Remark: the P. fluorescens PHZF gene is part of a seven gene cluster, containing phzABCDEFG.; Remark: the broad-spectrum antibiotic phenazine-1-carboxylic acid (PCA) is active against a variety of fungal root pathogens.; Title: similarity to phenazine biosynthesis oxidoreductase phzF - Pseudomonas fluorescens; See PMID 9573209
An11g07420	Similarity: similarities correspond to multiple G-repeats.
An11g07440	Similarity: similarities correspond to multiple glutamine repeats.
An11g07450	Function: the C. elegans PKC1B gene product catalyzes the formation of peptidyl-serine-phosphate or peptidyl-threonine-phosphate using ATP.; Remark: activity of the C. elegans protein kinase C is calcium-independent, phospholipid-dependent, and activated by diacylglycerol and by tumor-promoting phorbol esters; Title: similarity to neuronal protein kinase C PKC1B - Caenorhabditis elegans; See PMID 8132661
An11g07490	Complex: S. cerevisiae Hoc1 forms the Golgi membrane mannosyltransferase A-complex with Anp1, Mnn9, Mnn10, and Mnn11.; Function: S. cerevisiae Hoc1 is an alpha-1,6-mannosyltransferase involved in protein mannosylation and O-glycosylation at the Golgi membrane.; Golgi; Title: similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 10635561; See PMID 9055074
An11g07510	Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Complex: A. oxidans 6-HDNO is covalently flavinylated.; Function: A. oxidans 6-HDNO is involved in nicotine catabolism.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and A. oxidans 6-HDNO.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516
An11g07530	Function: Notchless protein of D. melanogaster binds to the cytoplasmic domain of Notch, suggesting that it serves as a direct regulator of Notch signaling activity.; Remark: WD-repeat proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as signal transduction, transcription, and proliferation.; Similarity: similarity to WD40-domain containing DNA-binding proteins.; Title: similarity to protein Notchless - Drosophila melanogaster; cytoplasm; See PMID 9590294; See PMID 9857191
An11g07550	Catalytic activity: Pyruvate + lipoamide = S-acetyldihydrolipoamide + CO(2).; Title: weak similarity to pyruvate dehydrogenase pdhA - Alcaligenes eutrophus
An11g07570	Similarity: similarity corresponds to a short internal region.; Title: weak similarity to dsRNA-binding protein 4F.2 - Xenopus laevis; See PMID 7922339
An11g07590	Function: the A. thaliana CAF gene product contains an N-terminal DExH/DEAD-box type RNA helicase domain attached to a C-terminal RNaseIII-like domain; it may act through some type of RNA processing event(s); Title: similarity to RNA helicase/RNAseIII CAF -Arabidopsis thaliana; See PMID 10556049
An11g07600	Title: strong similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger
An11g07610	Similarity: the ORF encoded protein shows also weak similarity to putative transcriptional regulator C1327. 01C from Schizosaccharomyces pombe.; Title: weak similarity to transcriptional activator Mut3 - Pichia angusta
An11g07620	Similarity: weak similarity to short internal region of DNA-directed DNA polymerase catalytic chain -Trypanosoma brucei.; Title: strong similarity to hypothetical protein encoded by An08g09040 - Aspergillus niger
An11g07630	Remark: two isoforms of the MCT transporter have been isolated from R. norvegicus, catalyzing the lactic acid efflux from white skeletal muscle; differences of both isoforms MCT1 and MCT3 correspond to their regulation rather than their intrinsic properties.; Title: strong similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 10358105; See PMID 10510291
An11g07640	Alternative name: protein kinase clk; Function: the M. musculus Clk protein, expressed in bacteria, becomes efficiently phosphorylated in vitro on tyrosine as well as serine/threonine, and phosphorylates the exogenous substrate poly(glu, tyr) on tyrosine.; Title: similarity to protein kinase STY - Mus musculus; See PMID 1825055
An11g07650	Catalytic activity: donor + H(2)O(2) = oxidized donor + 2H(2)O.; Remark: AOP2 from mouse is higly expressed in heart,kidney and liver.; Remark: a synonyme for AOP2 from mouse is LTW4.; Title: strong similarity to antioxidant protein AOP2 - Mus musculus; See PMID 9205120; See PMID 9806838
An11g07660	Catalytic activity: Successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Remark: beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall, could also function biosynthetically as a transglycosylase.; Title: similarity to exo-1,3-beta-glucanase Xog -Candida ablicans
An11g07670	Title: strong similarity to hypothetical protein EAA61442.1 - Aspergillus nidulans
An11g07680	Alternative name: YDR299W (MIPS); Function: the S. cerevisiae BFR2 gene product partially suppresses the growth defects induced by the fungal metabolite Brefeldin A (BFA), which disrupts the Golgi apparatus and its incoming protein flux.; Title: strong similarity to brefeldin A resistance protein Bfr2 - Saccharomyces cerevisiae; See PMID 9472076; See PMID 9645427
An11g07690	Similarity: patentmatch against cytoplasmic protein W21013 Patentprot.; Title: similarity to cytoplasmic protein hp5e15211orf13 from patent WO9640893-A1 - Helicobacter pylori; cytoplasm
An11g07700	Similarity: patentmatch against esterase es4 W23084 Patentprot.; Title: similarity to esterase es4 from patent WO9730160-A1 - Cetacea sp.
An11g07730	Similarity: the similarities of the ORF encoded protein to Muc4 from H. sapiens and the other proteins are mainly based on repetitive structures.; Title: similarity to mucin MUC4 - Homo sapiens; See PMID 10851560
An11g07750	Remark: the patent does not provide information about enzymatic activity of the protein.; Remark: the patent match is against the protein sequence of patent WO9621732-A/1 (AC# A52373).; Remark: the patented protein p43 and related polypeptide(s) which bind to interleukin receptor will be useful for treatment and diagnosis of IL-2 related disease,and to study mechanism of IL-2 mediated signal transduction.; Title: strong similarity to interleukin-2 receptor associated protein p43 from patent WO9621732-A - Mus musculus
An11g07760	Remark: the patent does not give information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to protein sequence 365 from patent WO0100843 (AC# AX064083) and several putative peptidases.; Title: strong similarity to sequence 365 from patent WO0100843 - Corynebacterium glutamicum
An11g07780	Function: Mrp2 of O. cuniculus mediates hepatobiliary excretion of numerous organic anions. Mrp2 of O. cuniculus confers a cAMP-activated chloride conductance that is inhibited by the chloride channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamine)benzoic acid,and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid.; Localization: Mrp2 of O. cuniculus is an integral protein of the apical membrane of epithelial cells.; Similarity: the predicted A. niger protein shows similarity to multidrug resistance-associated protein Mrp2 of several mammalian species. Mrp2 belongs to the MRP subfamily within the ATP- binding transport protein family (ABC transporters).; Tissue specificity: Mrp2 of O. cuniculus is expressed in liver, kidney and small intestine.; Title: strong similarity to multidrug resistance-associated protein Mrp2 - Oryctolagus cuniculus; plasma membrane; See PMID 8643587; See PMID 9614209
An11g07790	Title: similarity to hypothetical protein encoded by An14g02830 - Aspergillus niger
An11g07800	Function: the human erythrocyte ankyrin ANK1 attachs integral membrane proteins to cytoskeletal elements. it binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein.; Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 8226993; See PMID 8640229; See PMID 1689849
An11g07810	Title: weak similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis
An11g07820	Function: MRP-enriched membrane vesicles have demonstrated that the protein can bind and transport cysteinyl leukotrienes, as well as some other glutathione conjugates, with high affinity. in contrast, there is no direct evidence of the ability of MRP to bind or transport unmodified forms of the drugs to which it confers resistance. cells transfected with MRP displayed increased resistance to vincristine (5-6-fold) and doxorubicin (< 2-fold).; Similarity: the predicted protein of A. niger shows similarity to fungal and mammalian multidrug-resistance proteins (MRP).; Tissue specificity: MRP mRNA expression in some tissues is cell-type specific.; Title: strong similarity to multidrug resistance protein MRP - Mus musculus [putative frameshift]; plasma membrane; putative frameshift; See PMID 8649356
An11g07830	Title: strong similarity to hypothetical peptide transporter mtd1 - Schizophyllum commune; See PMID 10501939
An11g07840	Similarity: similarities may be due to repetitive sequences.
An11g07900	Title: similarity to hypothetical protein encoded by An16g02740 - Aspergillus niger
An11g07910	Title: strong similarity to hypothetical protein encoded by An18g04450 - Aspergillus niger
An11g07920	Remark: the protein sequence of patent WO200055320-A1 (AC# AAB54096) covers a ribosomal protein L33-like protein. the same sequence is covered by another patent WO9936524-A1 (AC# AAY29322).; Title: similarity to pancreatic cancer antigen from patent WO200055320-A1 - Homo sapiens
An11g07930	Complex: desmoplakin of H. sapiens forms a two-stranded coiled coil structure.; Function: desmoplakin of H. sapiens may play a role in attaching intermediate filaments to the cell surface.; Localization: human desmoplakin is found at the innermost portion of the desmosomal plaque.; Remark: human dpI and dpII derive from the same gene by alternative splicing.; Remark: the patent match is against the protein sequence breast cancer associated antigen precursor of patent WO9904265-A2 (AC# AAY07031), which covers the C-terminal half of human desmoplakin.; Similarity: the predicted A. niger protein shows similarity to desmoplakin I and II (dpI and dp II) of H. sapiens and coiled-coil domains of other proteins.; Tissue specificity: dpI is apparently an obligate constituent of all desmosomes, whereas dpII resides predominantly in tissues and cells of stratified origin. desmoplakins I and II are the major high molecular weight desmosome proteins.; Title: similarity to desmoplakin I DPI - Homo sapiens; cytoskeleton
An11g07950	Catalytic activity: the Bacillus subtilis myo-inositol 2-dehydrogenase converts Myo-inositol and NAD(+) to 2,4,6/3,5-pentahydroxycyclohexanone and NADH.; Induction: the Bacillus subtilis myo-inositol 2-dehydrogenase is induced by myo-inositol and is strongly repressed by rapidly metabolizable carbohydrates such as D-glucose, D-mannose, D-fructose and glycerol .; Title: strong similarity to myo-inositol 2-dehydrogenase yisS - Bacillus subtilis; See PMID 6322857
An11g07960	Function: the A. oryzae glutaminase is an aminohydrolase that hydrolyses glutamin to glutamate and ammonia.; Remark: the purified A. oryzae glutaminase catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006
An11g07970	Title: strong similarity to hypothetical protein SPBC16H5.12c - Schizosaccharomyces pombe
An11g07980	Function: YAP1 gene disruption experiments in K. lactis indicated that the gene is involved in both the oxidative and cadmium response pathways.; Function: the K. lactis YAP1 mediates AP-1 response element-dependent transcriptional activation in response to H2O2 in S. cerevisiae.; Remark: the K. lactis YAP1 was cloned by functional complementation of the mutant phenotype of a S. cerevisiae strain lacking functional YAP1 and YAP2 genes.; Remark: the similarity of the predicted A. niger protein to the transcription factor YAP1 is restricted to the N-terminal part of the A. niger protein (aa 119-222).; Title: weak similarity to transcription factor YAP1 - Kluyveromyces lactis; nucleus; See PMID 9439570
An11g08010	Title: similarity to hypothetical protein SPCC1281.02c - Schizosaccharomyces pombe
An11g08020	Function: the M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the M. grisea PTH11, a pathogenicity gene predicted to encode a novel transmembrane protein is localized in the cell membrane and in vacuoles.; Title: strong similarity to G-11 integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An11g08030	Function: the A. nidulans STCW may be involved in the hydroxylatioin of averantin to 5'-hydroxyaverantin.; Pathway: The ST biosynthetic pathway in Aspergillus nidulans is estimated to involve at least 15 enzymatic activities; Remark: Sterigmatocystin (ST) is a mycotoxin with the molecular formula C18 H12 O6 who is closly related to alflatoxin and produced by several species of Aspergillus sp.; Title: strong similarity to hypothetical sterigmatocystin biosythesis monooxygenase stcW -Aspergillus nidulans; See PMID 8643646
An11g08040	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An11g08050	Remark: the AKT2 protein is involved in production and pathogenicity of the fungal AK-toxin, which is a pathotype called black spot on japanese pears.; Title: strong similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 - Alternaria alternata; See PMID 10432635
An11g08060	Function: the M. musculus HCDH catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA.; Localization: the M. musculus HCDH is predicted to be in at least two different compartments of the cell, the mitochondria and the peroxisomes.; Pathway: the M. musculus 3-hydroxyacyl-CoA dehydrogenase (HCDH) is an enzyme involved in fatty acid metabolism.; Remark: the similarity of the predicted A. niger protein to the M. musculus HCDH is restricted to the N-terminal region.; Similarity: the predicted A. niger protein contains the dehydratase domain (aa 194-204, PF00725) as well as the NAD-binding domain (aa 0-192, PF02737).; Title: similarity to 3-hydroxyacyl-CoA dehydrogenase HCDH - Mus musculus; See PMID 7642117
An11g08070	Catalytic activity: the H. sapiens acetylcholinesterase catalyses the cleavage of acetylcholine and H(2)O to choline and acetate thus reducing the concentration of the neurotransmitter acetycholin within the neural cleft.; Complex: acetylcholinesterase of H. spaiens exists a homodimer linked by a disulfide bridge.; Remark: the human acetylcholinsterase acts on a variety of acetic esters; also catalyses transacetylations and is inhibited by tacrine.; Title: strong similarity to acetylcholinesterase ACHE - Homo sapiens; See PMID 2263619; See PMID 2714437
An11g08080	Catalytic activity: O-methyltransferase I catalyzes both the conversion of demethylsterigmatocystin to sterigmatocystin and the conversion of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis.; Remark: sterigmatocystin (ST) is a mycotoxin with the molecular formula C18 H12 O6, which is closly related to alflatoxin and produced by several species of Aspergillus sp.; Remark: the predicted A. niger protein contains a PF00891 O-methyltransferase consensus sequenze (aa 119-374) and a leucin zipper domain (aa 249-278).; Title: strong similarity to cDNA O-methyltransferase mt-I - Aspergillus parasiticus; See PMID 10543813
An11g08090	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An11g08100	Title: strong similarity to hypothetical protein encoded by An12g06830 - Aspergillus niger
An11g08120	Similarity: the ORF encoded protein shows also weak similarity to cDNA hypothetical serine-rich protein SPCC553. 10 from Schizosaccharomyces pombe.; Title: weak similarity to hypothetical protein encoded by An11g05490 - Aspergillus niger
An11g08130	Pathway: the D. melanogaster SRPK1 identified as a kinase specific for the SR family of splicing factors.; Remark: the similarity between the predicted A. niger protein and the D. melanogaster SRPK1 protein is restricted to the Serin/threonin kinase domain (aa 15 - 59,COG0515).; Title: weak similarity to SR protein kinase 1 SRPK1 - Drosophila melanogaster; See PMID 11158320
An11g08140	Catalytic activity: endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products.; Complex: nucS of A. oryzae exists as a monomer.; Function: the A. oryzae nuclease S1 hydrolyses single stranded DNA from protuding ends or endonucleolytical.; Title: strong similarity to nuclease S1 gene nucS -Aspergillus oryzae; See PMID 8597544; See PMID 1939022
An11g08150	Remark: the predicted A. niger protein exhibits also local similarity to the hypothetical yukJ from B. subtilis within its central part (aa 138-230).; Title: strong similarity to hypothetical protein BAB74777.1 - Nostoc sp.
An11g08160	Remark: the similarity of the predicted A. niger protein (aa 2-277) is restricted to the N-terminal part of the to the C. crescentus protein.; Title: similarity to hypothetical peptidoglycan binding domain protein CC2696 - Caulobacter crescentus
An11g08180	Title: similarity to hypothetical protein slr1968 -Synechocystis sp.
An11g08190	Remark: when expressed in Xenopus oocytes, the encoded protein of the rat designated as TAT1 (T-type amino acid transporter 1) exhibited Na+-independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine (Km values: approximately 5 mm), consistent with the properties of classical amino acid transport system T. Distinct from H+/monocarboxylate transporters, however, TAT1 was not coupled with the H+ transport but it mediated an electroneutral facilitated diffusion.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to T-type amino acid transporter 1 TAT1 - Rattus norvegicus; See PMID 11278508
An11g08200	Title: strong similarity to hypothetical protein EAA59978.1 - Aspergillus nidulans
An11g08220	Remark: similarity to Neisseria meningitidis Hsp70 patent WO200034465-A2.; Title: similarity to heat shock protein 70 Hsp70 from patent WO200034465-A2 - Neisseria meningitidis
An11g08240	Title: questionable ORF
An11g08250	Title: strong similarity to tyrosine decarboxylase tyrDC - Enterococcus faecalis; See PMID 12089039
An11g08260	Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 58222 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:58222 from patent EP1033405-A2 - Arabidopsis thaliana
An11g08280	Remark: Northern blotting revealed a unique tissue distribution for the expression of mRNA for MTC3. MTC3 is expressed in retinal pigment epithelium (RPE).; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836
An11g08290	Function: FAH is a cytochrome P450-linked monoxygenase, which catalyses the conversion of ferulic acid to 5-hydroxyferulic acid, which is an internediate of sinapine.; Remark: similarity to Amino acid sequence of pJOY3 ferulic acid hydroxylase cDNA clone patent CA2270417-A1.; Title: similarity to ferulic acid hydroxylase FAH from patent CA2270417-A1 - Brassica napus
An11g08300	Remark: the ORF is short in length (47 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An11g08320	Remark: FLR1 S. cerevisiae gene confers resistance to the antimitotic systemic benzimidazole fungicide benomyl and the antitumor agent methotrexate, reinforcing the concept that the FLR1 gene is a multidrug resistance (MDR) determinant. activation of FLR1 expression in benomyl-stressed cells is under the control of the transcriptional regulator Pdr3p.; Remark: alternative name is YBR008c.; Similarity: belongs to the permeases of the major facilitator superfamily and the benomyl/methotrexate resistance protein family.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 10572257
An11g08330	Remark: strong similarity to Pseudomonas sp. WF505 ORF6-6 protein, SEQ ID NO:11 patent JP2000093180-A found in PATENTPROT:AAY97823.; Remark: the decribed Pseudomonas sp. WF505 protein is believed to be useful for the desulfurization of crude oil as component of the benzothiophene oxidase gene cluster of Pseudomonas sp. WF505.; Title: strong similarity to ORF6-6 protein from patent JP2000093180-A - Pseudomonas sp.; See PMID 8021182; See PMID 9783422
An11g08340	Title: similarity to hypothetical protein encoded by An02g12600 - Aspergillus niger
An11g08350	Title: similarity to cellular proliferation protein #164 from patent WO200170955-A2 - Streptococcus pneumoniae
An11g08370	Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825
An11g08390	Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the C-terminal region of Agrobacterium tumefaciens, which is 371 aa long.; Title: weak similarity to hypothetical protein ymc -Argrobacterium tumefaciens
An11g08400	Title: strong similarity to hypothetical protein YEL023c - Saccharomyces cerevisiae
An11g08410	Function: members of the quinone reductase family are catalyzing the nicotinamide nucleotide-dependent reduction of quinones to reduce their toxic effects.; Title: strong similarity to zeta-crystallin / quinone reductase CYGPZ - Cavia porcellus; See PMID 1370456; See PMID 11340659; See PMID 1989495
An11g08430	Title: weak similarity to hypothetical protein encoded by An15g03810 - Aspergillus niger
An11g08440	Function: C. acetobutylicum bcd catalyses the formation of butyryl-CoA from acetoacetyl-CoA essential for acid and solvent formation by clostridia.; Title: similarity to 3-hydroxybutyryl-CoA dehydrogenase bcd - Clostridium acetobutylicum; See PMID 8655474
An11g08460	Function: A. niger aox1 transfers electrons directly from ubichinol to oxygenen forming water without translocation of protons across the inner mitochondrial membrane.; Remark: the A. niger alternative oxidase is used as a second terminal oxidase in the mitochondria.; Title: strong similarity to alternative oxidase aox1 - Aspergillus niger; localisation:mitochondrion; See PMID 9933359; See PMID 11106766
An11g08470	Complex: the S. cerevisiae transcription activator CHA4 interacts with two serine/threonine response elements in the CHA1 promoter, UASCHA.; Function: the S. cerevisiae transcription activator CHA4 regulates the transcription of the CHA1 gene, which encodes a catabolic L-serine (L-threonine) deaminase responsible for the utilization of serine/threonine as nitrogen sources.; Title: weak similarity to transcription activator Cha4 - Saccharomyces cerevisiae; See PMID 8889513
An11g08500	Complex: S. lactamdurans 7 alpha-cephem-methoxylase two-protein component system formed by cmcI and cmcJ.; Function: S. lactamdurans cmcJ forms part of the 7 alpha-cephem-methoxylase which converts the antibiotic cephalosporin C to 7-methoxycephalosporin C.; Title: similarity to hypothetical 7alpha-cephem-methoxylase subunit cmcJ - Streptomyces lactamdurans; See PMID 7721717
An11g08510	Catalytic activity: NADPH dehydrogenases catalyse the reaction, NADPH + acceptor = NADP+ + reduced acceptor.; Complex: S. cerevisiae OYE3 forms homodimers and heterodimers with other OYE Isoforms.; Function: S. cerevisiae OYE3 binds a variety of compounds with a phenolic structure.; Function: S. cerevisiae OYE3 has been shown to catalyze efficiently the NADPH-linked reduction of nitro-olefins.; Function: S. cerevisiae OYE3 might be involved in sterol metabolism.; Remark: the OYE (old yellow enzyme) of S. cerevisiae binds phenolic ligands forming long wavelength (500-800 nm) charge-transfer complexes.; Title: strong similarity to hypothetical NADPH dehydrogenase Oye3 - Saccharomyces cerevisiae; See PMID 7836424; See PMID 10995477
An11g08520	Similarity: only the N-terminal regions have similarities.; Title: weak similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 11035941
An11g08530	Catalytic activity: Z. rouxii krd reduces alpha-ketolactones, alpha-ketolactams, and diketones.; Function: Z. rouxii krd catalyzes the asymmetric reduction of selected ketone substrates like 3,4-methylenedioxyphenyl acetone.; Similarity: substrate specificity, lack of a catalytic metal, and similarity to known reductases suggests that Z. rouxii krd is a carbonyl reductase.; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208
An11g08540	Similarity: protein homologues due to repetitive sequence.
An11g08550	Title: similarity to hypothetical transcription factor SPAPB1A11.04c - Schizosaccharomyces pombe
An11g08600	Title: weak similarity to JUN-like transcription factor jlbA - Aspergillus nidulans
An11g08610	Remark: VC16-16MC is a thermostable esterase of Archaeoglobus fulgidus VC16.; Remark: patentmatch is a protein. accession number is W23076.; Similarity: belongs to the esterase/lipase family.; Title: strong similarity to esterase VC16-16MC from patent WO9730160-A1 - Archaeoglobus fulgidus
An11g08620	Title: strong similarity to cercosporin transporter AAC78076.1 - Cercospora kikuchii; See PMID 10517030
An11g08650	Function: the NAM7/UPF1 gene suppresses mitochondrial splicing deficiency when present in multiple copies.; Remark: the NAM7 protein of S. cerevisiae contains several motifs typical for proteins interacting with nucleic acids: (1) five motifs diagnostic for a superfamily of helicases appear in the same order and with similar distances; (2) the N-terminal portion possesses potential Zn-ligand structures belonging to the C chi superfamily.; Similarity: the predicted A. niger protein shows similarity to prematurely terminated mRNA decay factor NAM7 (UPF1) of S. cerevisiae and to several putative DNA helicase like proteins.; Title: similarity to prematurely terminated mRNA decay factor Nam7 - Saccharomyces cerevisiae; See PMID 7506349; See PMID 9199511
An11g08670	Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443
An11g08700	Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus aculeatus [putative frameshift]; putative frameshift
An11g08720	Title: weak similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger
An11g08730	Title: similarity to hypothetical protein encoded by An09g01180 - Aspergillus niger
An11g08750	Remark: rfbM acts sequentially with phosphomannomutase to form GDP-mannose, which serves as the activated sugar nucleotide precursor for mannose residues in cell surface and capsular polysaccharides in Escherichia coli.; Title: weak similarity to GDP-mannose pyrophosphorylase rfbM - Escherichia coli; See PMID 7515042
An11g08760	Remark: truncated due to contig end.
An11g08770	Title: similarity to hypothetical agglutinin-like protein - Candida albicans
An11g08780	Title: strong similarity to hypothetical protein AAP25659.1 - Bacillus anthracis
An11g08790	Title: similarity to hypothetical protein yukJ -Bacillus subtilis
An11g08810	Function: gibberlin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641
An11g08820	Function: methionine is transported into yeast cells by three different permeases, a high affinity (MUP1) and two low affinity permeases.; Remark: S. cerevisiae MUP1 was shown to encode an integral membrane protein with 13 putative membrane-spanning regions.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8893857
An11g08830	Remark: an alternative name for Magnaporthe grisea is Pyricularia grisea.; Similarity: similarity is between the fungal Gal4 type Zn(2)-Cys(6) DNA-binding domains in the N-terminal region of the predicted A. niger protein and M. grisea PIG1.; Title: weak similarity to transcription factor PIG1 - Magnaporthe grisea; nucleus; See PMID 11123670
An11g08840	Title: strong similarity to 19.3 kD subunit of NADH:ubiquinone reductase PSST - Bos taurus; localisation:mitochondrion
An11g08850	Function: S. scrofa RGD-CAP enhances the spreading of chondrocytes and fibroblasts via integrin alpha(1)beta(1), which does not require binding to the RGD domain.; Function: the RGD sequence of S. scrofa RGD-CAP may serve as a recognition sequence for integrins.; Similarity: S. scrofa RGD-CAP is a fasciclin-like adhesion protein and the predicted A. niger protein contains a fasciclin domain.; Title: weak similarity to collagen fiber-associated protein RGD-CAP - Sus scrofa; See PMID 9061001; See PMID 9512662; See PMID 10446401
An11g08860	Title: strong similarity to EST o0f12a1.r1 -Aspergillus nidulans
An11g08870	Catalytic activity: ornithine transaminase convert L-ornithine + a 2-oxo acid to L-glutamate 5-semialdehyde + an L-amino acid.; Function: A. nidulans otaA is involved in arginine catabolism and nitrogen utilisation.; Induction: expression of A. nidulans otaA is specifically induced by arginine.; Regulation: regulation of A. nidulans otaA occurs at both transcriptional and post-transcriptional levels.; Repression: expression of A. nidulans otaA is under the control of nitrogen-metabolite and carbon-catabolite repression.; Title: strong similarity to ornithine transaminase otaA - Aspergillus nidulans; See PMID 10079330
An11g08880	Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563
An11g08890	Function: S. aureus hmrA conferred Eagle-type resistance, i. e. resistance to high concentrations of methicillin (64 to 512 microg/ml) and susceptibility to low concentrations of methicillin (2 to 16 microg/ml), when introduced into the cell in multiple copies.; Similarity: the predicted A. niger protein shows similarity to several putative hydrolase proteins and contains a hydrolase BLOCKs motif.; Title: strong similarity to methicillin resistance gene HmrA - Staphylococcus aureus; See PMID 11181367
An11g08900	Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667; See PMID 7847883; See PMID 9044292
An11g08910	Similarity: the ORF encoded protein shows weak similarities to many fungal Zn(2)-Cys(6) binuclear type transcription factors. The similarity of the ORF encoded protein to Lys14 concerns only the DNA binding domain with the binuclear zinc cluster.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae
An11g08920	Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Similarity: the c-terminal part of the ORF encoded protein shows similarity to many ankyrins and ankyrin homologs.; Title: similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 7557402; See PMID 9435787
An11g08930	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the ORF encoded protein and nirA from A. nidulans are fungal Zn(2)-Cys(6) binuclear type transcription factors.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1990284
An11g08940	Title: strong similarity to hypothetical protein YDR533c - Saccharomyces cerevisiae
An11g08950	Similarity: the ORF encoded protein shows also strong similarity (e-val. : 2e-59) to the stress induced human oxidoreductase PIG3 (p53-inducible gene 3; Pubmed 11158615) of unknown function. It also shows strong similarity (e-val. : 5e-31) to the actVI-ORF2 oxidoreductase from Streptomyces coelicolor involved in actinorhodin biosynthesis (Pubmed 10805574).; Title: strong similarity to oxidoreductase protein HORP-4 from patent WO200000622-A2 - Homo sapiens
An11g08960	Title: weak similarity to Sucrose-phosphate-synthase from patent DE4317596-A - Beta vulgaris
An11g08980	Remark: Fugu rubripes=Japanese pufferfish.; Similarity: the ORF encoded protein shows also weak similarity to the D2-like dopamine receptor from Fugu rubripes.; Title: weak similarity to hypothetical protein CAD70538.1 - Neurospora crassa
An11g08990	Function: When the S. cerevisiae TPO1/YLL028w gene was disrupted by inserting the HIS3 gene, the cells became sensitive to polyamines, and spermine uptake activity of isolated vacuolar membrane vesicles decreased significantly.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows stonger similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A, but the patent does not describe its function precisely enough.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864
An11g09000	Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Function: the GST from E. coli catalyzes the conjugation of glutathione to a large variety of electrophilic compounds of endobiotic and xenobiotic origin. It is also involved in intracellular binding and transport of hydrophobic compounds and involved in detoxification of organic hydroperoxides.; Title: strong similarity to glutathione transferase GST - Escherichia coli; See PMID 7798255
An11g09010	Similarity: the rat choline kinase R2 is identical to the protein described in patent JP05015367-A.; Title: weak similarity to choline kinase R2 CK-R2 -Rattus norvegicus
An11g09030	Catalytic activity: UDP-glucuronate + acceptor <=> UDP + acceptor beta-D-glucuronoside.; Function: the rat UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. It is also active on testosterone.; Remark: alternate names for the rat UDPGT : RLUG38 or UGT2B3.; Title: similarity to UDP-glucuronosyltransferase 3 precursor UDPGT - Rattus norvegicus; See PMID 3110162; See PMID 7492328
An11g09050	Title: strong similarity to hypothetical protein encoded by An03g06750 - Aspergillus niger
An11g09060	Title: weak similarity to bacteriophage resistance mechanism subunit HsdR from patent FR2767831-A1 -Lactococcus lactis
An11g09080	Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Similarity: the ORF encoded protein shows similarity to many hypothetical flavoprotein oxidoreductases. The similarity of the ORF encoded protein to the 6-hydroxy-D-nicotine oxidase 6-HDNO from A. oxidans only concerns the N-terminal protein part. Even the similarity to the MmcM product from S. lavendulae is more extended,but this enzyme involved in the mitomycin C from Streptomyces lavendulae is biochemically not enough characterized.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2115879; See PMID 2680607
An11g09110	Title: strong similarity to hypothetical protein B12F1.100 - Neurospora crassa
An11g09120	Remark: alternate names for cytosolic ribosomal protein L26 from S. cerevisiae: RPL26B or YGR034W.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L26 - Saccharomyces cerevisiae; cytoplasm; See PMID 9672752; See PMID 1733947
An11g09130	Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Similarity: the ORF encoded protein also shows stong similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257
An11g09140	Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the ORF encoded protein shows stonger similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A, but the patent does not describe its function precisely enough.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353
An11g09150	Similarity: Gal4 from S. cerevisiae belongs to the fungal binuclear zinc cluster transcription factor family.; Title: weak similarity to transcription factor Gal4 - Saccharomyces cerevisiae; See PMID 1557122
An11g09160	Remark: the deletion Emericella nidulans aflR gene results in an inability to induce expression of genes within the ST (sterigmatocystin) gene cluster and a loss of ST production. Sterigmatocystin is a carcinogenic secondary metabolite related to aflatoxin.; Similarity: the ORF encoded protein shows also similarity to the AflR homologs from Aspergillus parasiticus and Aspergillus flavus.; Similarity: the ORF encoded protein, the AflR protein from Emericella nidulans and its homologs are transcriptional regulators of the fungal binuclear zinc cluster type.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194
An11g09170	Catalytic activity: the SAP8 protease from C. albicans preferential cleaves at the carboxyl end of hydrophobic amino acids, but fails to cleave 15-Leu-Tyr-16,16-Tyr-Leu-17 and 24-Phe-Phe-25 of insulin beta chain. It activates trypsinogen, and degrades keratin.; Remark: alternate names for C. albicans SAP8: ACP 8,aspartate protease 8 or secreted aspartic protease 8.; Similarity: the SAP8 protease from C. albicans belongs to peptidase family A1; also known as the eukaryotic aspartyl proteases family.; Title: similarity to secreted aspartic proteinase SAP8 - Candida albicans; extracellular/secretion proteins; See PMID 9802014
An11g09180	Remark: mutations in tol (N. crassa) are recessive and suppress mating-type-associated heterokaryon incompatibility.; Similarity: the similarity of the ORF encoded protein to the N. crassa tol protein does not extend over the complete length.; Title: similarity to mediator of mating-type-associated vegetative incompatibility tol -Neurospora crassa; See PMID 9927450
An11g09190	Title: weak similarity to hypothetical stress response protein rds1p - Schizosaccharomyces pombe; See PMID 7565608
An11g09200	Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein F7O12 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein encoded by An04g04070 - Aspergillus niger
An11g09210	Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa
An11g09230	Catalytic activity: Urea <=> cyanamide + H(2)O.; Cofactor: Zinc.; Remark: the cyanamide hydratase from Myrothecium verrucaria is also decribed in patent WO9848023-A1.; Title: strong similarity to cyanamide hydratase -Myrothecium verrucaria; See PMID 2034671
An11g09240	Catalytic activity: the Yps1 protease form S. cerevisiae hydrolyzes various precursor proteins with Arg or Lys in position 1(p1), and commonly Arg or Lys also in position 2(p2). The position 3(p3) amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions.; Function: the Yps1 protease form S. cerevisiae cleaves at paired basic residues. It can process the alpha-mating factor precursor.; Remark: alternate names for S. cerevisiae Yps1: YLR120C or Yapsin 1 or aspergillopepsin. Yap3 is confusing because it is also a name for a transcription factor in S. cerevisiae.; Similarity: the Yps1 protease form S. cerevisiae belongs to peptidase family A1; also known as the eukaryotic aspartyl proteases family.; Title: similarity to Gpi-anchored aspartic protease Yps1 - Saccharomyces cerevisiae; See PMID 8389368; See PMID 9485427
An11g09250	Title: strong similarity to hypothetical protein encoded by An11g05630 - Aspergillus niger
An11g09260	Remark: alternate names for the rat mitochondrial vitamin D3 25-monooxygenase cytochrome P450 27 precursor: cholesterol 26-hydroxylase; cytochrome P450 CYP27; cytochrome P450c26/25; cytochrome P450mt3,phenobarbital-inducible; vitamin D3 25-hydroxylase.; Similarity: the ORF encoded protein is only similar to the C-terminal part of the rat vitamin D3 25-monooxygenase a part which is conserved in most p450 enzyms. Both proteins are only distantly related, so a functional prediction is impossible. The ORF encoded protein shows (very) strong similarity to the unknown p450-4 enzym from Gibberella fujikuroi.; Title: similarity to precursor of mitochondrial vitamin D3 25-monooxygenase cytochrome P450 - Rattus norvegicus; See PMID 2175615
An11g09270	Catalytic activity: 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Pathway: the dihydroxy-acid dehydratase from Zea mays catalyzes the fourth step in valine and isoleucine biosynthesis.; Similarity: the ORF encoded protein shows also strong similarity to the known dihydroxy-acid dehydratases Ilv3 (S. cerevisiae Pubmed 8299945) and IlvD (B. subtilis).; Title: strong similarity to dihydroxy-acid dehydratase from patent WO9921880-A2 - Zea mays
An11g09280	Remark: ORF 5'truncated due to end of contig.
An11g09300	Remark: ORF 3'truncated due to end of contig.
An11g09310	Title: strong similarity to hypothetical protein SPBC337.17c - Schizosaccharomyces pombe
An11g09320	Catalytic activity: uridine kinase convert ATP + Uridine to ADP + UMP.; Function: S. cerevisiae urk1 phosphorylates Cytidine into CMP.; Title: strong similarity to uridine kinase Urk1 -Saccharomyces cerevisiae; See PMID 7900425; See PMID 10501935; See PMID 2169608
An11g09330	Title: strong similarity to hypothetical protein F11P17.12 - Arabidopsis thaliana
An11g09340	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein Rv0976c from Mycobacterium tuberculosis.; Title: similarity to hypothetical protein Rv0976c -Mycobacterium tuberculosis
An11g09350	Catalytic activity: NADH dehydrogenases convert NADH + ubiquinone to NAD(+) + ubiquinol.; Localization: N. crassa ndh64 is located in the inner membrane of mitochondria, possibly facing the matrix side.; Similarity: N. crassa ndh64 shows strong similarity to mitochondrial NADH dehydrogenases from yeast, however it contains a well-conserved calcium-binding domain.; Title: strong similarity to mitochondrial NADH dehydrogenase ndh64 - Neurospora crassa; localisation:mitochondrion; See PMID 10482790
An11g09360	Function: C. cinereus rad9 acts as a sister chromatid cohesion molecule.; Function: the rad9 gene of C. cinereus encodes a proline-rich protein required for meiotic chromosome condensation and synapsis.; Title: similarity to proline-rich protein Rad9 -Coprinus cinereus; nucleus; See PMID 7753026; See PMID 8846891
An11g09370	Catalytic activity: RNA polymerase I catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Function: A12. 2 plays a role in the assembly of A190, the largest subunit of RNA polymerase I, into a stable polymerase I structure.; Function: RNA polymerase I can initiate a chain de novo.; Function: S. cereviaisae RPA12 encodes the A12. 2 subunit of RNA polymerase I and is essential only at high temperatures.; Remark: alternate names for RPA12 of S. cerevisiae are A12. 2 or RRN4.; Title: strong similarity to 13.7 kD subunit of DNA-directed RNA polymerase I Rpa12 - Saccharomyces cerevisiae; nucleus; See PMID 8417319; See PMID 9121426
An11g09380	Title: strong similarity to hypothetical protein YJR070c - Saccharomyces cerevisiae
An11g09390	Catalytic activity: NADH:ubiquinone oxidoreductase converts NADH + ubiquinone to NAD(+) + ubiquinol.; Title: strong similarity to 21 kD subunit of NADH:ubiquinone reductase nuo-21 - Neurospora crassa; localisation:mitochondrion; See PMID 7947902
An11g09400	Complex: S. cerevisiae ATP17 is part of the hydrogen-transporting ATP synthase F0 sector (Subunit f of mitochondrial ATP synthase).; Function: S. cerevisiae ATP17 is a hydrogen-transporting two-sector ATPase and is involved in ATP synthesis coupled proton transport.; Remark: the systematic name for S. cerevisiae ATP17 is YDR377W.; Title: similarity to subunit f of mitochondrial yeast ATP synthase Atp17 - Saccharomyces cerevisiae; localisation:mitochondrion
An11g09410	Title: similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger
An11g09420	Title: similarity to hypothetical protein encoded by An06g00740 - Aspergillus niger
An11g09430	Remark: homology found is only based on repetitive sequence.; Title: weak similarity to hypothetical protein encoded by An03g01410 - Aspergillus niger
An11g09440	Remark: Gene contains 5 WD repeats (trp-asp-domains) and belongs to the lec14B family of WD repeat proteins.; Remark: information concerning L. erythrorhizon LEC14B has not been published and is available from the Swissprot and EMBL databases.; Title: similarity to cDNA LEC14B - Lithospermum erythrorhizon; See PMID 10322433
An11g09450	Title: weak similarity to hypothetical protein MDF20.11 - Arabidopsis thaliana
An11g09460	Complex: using in vitro binding assays, S. cerevisiae Grd19p was found to interact physically with the cytosolic domain of DPAP A (dipeptidyl aminopeptidase A).; Function: S. cerevisiae GRD19 is involved in the process of retrieval of resident Golgi proteins from the prevacuolar compartment.; Function: S. cerevisiae Grd19p functions by direct interaction with the cytosolic tails of certain late-Golgi compartment membrane proteins during the sorting/budding process at the prevacuolar compartment.; Localization: S. cerevisiae Grd19p localises predominantly cytosolic.; Similarity: the predicted A. niger protein contains a PX (phox) domain which occurs in a variety of eucaryotic proteins associated with intracellular signaling pathways.; Title: strong similarity to component of the retrieval machinery Grd19 - Saccharomyces cerevisiae; cytoplasm; See PMID 9456318
An11g09470	Title: strong similarity to hypothetical protein EAA60367.1 - Aspergillus nidulans
An11g09490	Title: weak similarity to hypothetical protein encoded by An12g06920 - Aspergillus niger
An11g09500	Function: ribosomal proteins S12, S5 and S4 of E. coli are essential for the control of translational accuracy and the yeast equivalents, S28, S4 and S13, have also been implicated in this process.; Remark: S. cerevisiae S4. e belongs to the small subunit (40s) of the ribosome.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S4.e - Saccharomyces cerevisiae; cytoplasm; See PMID 6814480; See PMID 8950190
An11g09510	Catalytic activity: ASA DHs convert L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ to L-4-Aspartyl phosphate + NADPH.; Complex: S. cerevisiae Hom2 forms a homodimer.; Function: S. cerevisiae HOM2 encodes an aspartic semi-aldehyde dehydrogenase (ASA DH).; Function: S. cerevisiae HOM2 is involved in the threonine/methionine biosynthetic pathway.; Induction: expression of S. cerevisiae HOM2 is weakly stimulated by methionine but shows no response to threonine.; Induction: induction of S. cerevisiae HOM2 expression is mediated by GCN4 and therefore by the general amino acid control.; Title: strong similarity to aspartate-semialdehyde dehydrogenase Hom2 - Saccharomyces cerevisiae; See PMID 1789001; See PMID 2570346
An11g09520	Catalytic activity: D-lactate dehydrogenases convert (R)-Lactate + 2 Ferricytochrome c to Pyruvate + 2 Ferrocytochrome c.; Function: L- and D-lactate ferricytochrome c oxidoreductase (LCR) in yeast mitochondria catalyze the stereospecific oxidation of D and L isomers of lactate to pyruvate.; Function: oxidation of D-lactate is linked to the respiratory chain, cytochrome c being the electron acceptor of the redox reaction.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis; localisation:mitochondrion; See PMID 7969031
An11g09530	Title: similarity to essential protein #23383 from patent WO200277183-A2 - Neisseria meningitidis
An11g09540	Catalytic activity: RdRPs convert nucleoside triphosphate + RNA(n) to pyrophosphate + RNA(n+1).; Function: RdRPs are possibly involved in homology-dependent gene silencing.; Function: RdRPs catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time.; Function: RdRPs function in post-transcriptional gene silencing.; Function: tomato RdRP can initiate a chain de novo.; Induction: expression of tomato RdRP is induced by viroid infection.; Title: strong similarity to RNA-directed RNA polymerase RdRP - Lycopersicon esculentum; See PMID 9836747
An11g09550	Function: S. cerevisiae REV3 encodes the catalytic subunit of DNA polymerase (pol) zeta, which can replicate past certain types of DNA lesions.; Function: S. cerevisiae rev3 mutants are viable and have lower rates of spontaneous and DNA-damage-induced mutagenesis.; Title: strong similarity to DNA-directed DNA polymerase Rev3 - Saccharomyces cerevisiae; nucleus; See PMID 11050392; See PMID 2676986
An11g09560	Function: human hSlu7 is required for a structural alteration of the spliceosome prior to the establishment of the catalytically active spliceosome for step II.; Function: yeast SLU7 is only required when the interval between the branchpoint and the 3' splice site is greater than 7 nt.; Function: yeast pre-mRNA splicing factors SLU7 and PRP16 are required for cleavage of the 3' splice site and exon ligation in vitro.; Title: similarity to pre-mRNA splicing factor hSLU7 - Homo sapiens; nucleus; See PMID 7568198; See PMID 7664739; See PMID 9153314; See PMID 10197984; See PMID 1427075
An11g09570	Remark: 60S ribosomal protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L37.b - Saccharomyces cerevisiae; cytoplasm; See PMID 8082197; See PMID 1840541
An11g09580	Title: weak similarity to hypothetical protein YMR312w - Saccharomyces cerevisiae
An11g09590	Remark: the Gal4 transcription factor is a positive regulator of the galactose-inducible genes in S. cerevisiae and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 7601342; See PMID 10805731; See PMID 6366516
An11g09600	Function: C. kessleri HUP2 also has strong similarity to the predicted A. niger protein and was shown to be a galactose-H+ symporter.; Remark: the properties of the mutant suggest that RCO3 is required for expression of glucose transport activity, glucose regulation of gene expression, and general carbon repression of development.; Title: strong similarity to glucose transporter rco-3 - Neurospora crassa; plasma membrane; See PMID 7870840; See PMID 9178001
An11g09610	Complex: subunits of the mammalian COP9 complex,include regulators of the Jun N-terminal kinase (JNK) and c-Jun, a nuclear hormone receptor binding protein (TRP19/COPS2) and a cell-cycle regulator.; Complex: the mammalian COP9 complex consists of eight subunits, six of them showing high similarity to six distinct non-ATPase regulatory subunits of the 26S proteasome.; Function: all of the subunits of the COP9 complex contain structural features that are also present in the components of the proteasome regulatory complex and the translation initiation factor eIF3 complex.; Function: human SNG2 is a component of the signalosome or COP9 protein complex.; Function: the signalosome complex is an important cellular regulator modulating multiple signaling pathways.; Localization: the signalosome complex is found in the cytoplasm and the nucleus.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to signalosome subunit SGN2 - Homo sapiens [truncated ORF]; See PMID 10087198; See PMID 10585392
An11g09620	Function: S. cerevisiae Rho3 acts as a key regulator of cell polarity and exocytosis independet of its function as actin organising protein.; Similarity: S. cerevisiae Rho3 is a GTP-binding protein of the rho family.; Title: strong similarity to GTPase Rho3 -Saccharomyces cerevisiae; See PMID 10588647; See PMID 10998597
An11g09630	Function: K. lactis LIPB creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoate-dependent enzymes.; Title: strong similarity to lipoyl-protein ligase LIPB - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9268025
An11g09640	Title: strong similarity to hypothetical GTPase activating protein homolog GAP1 - Cochliobolus heterostrophus
An11g09650	Title: similarity to hypothetical protein NIPSNAP1 -Danio rerio
An11g09660	Catalytic activity: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.; Catalytic activity: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.; Remark: EPT1 requires a divalent cation activator,and is inhibited by CMP in S. cerevisiae.; Remark: The multiple transmembrane domains and lumenal hydrophilic domains of the EPT1 might participate in the transport process in S. cerevisiae.; Title: strong similarity to ethanolaminephosphotransferase Ept1 - Saccharomyces cerevisiae; plasma membrane; See PMID 1847919
An11g09670	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S27 - Homo sapiens; cytoplasm; See PMID 8908372
An11g09680	Catalytic activity: 5,6,7,8-tetrahydrofolate + nadp(+) = 7,8-dihydrofolate + nadph.; Remark: alternate names in Schizosaccharomyces pombe = dfr1 or spcc1223. 08c; Remark: essential step for de novo glycine and purine synthesis.; Remark: the predicted ORF is 214 amino acids shorter at the C-terminus than dfr1 of S. pombe.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538
An11g09690	Complex: Rpn5p is a subunit of the 19S proteasome regulatory particle.; Remark: subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn5 - Saccharomyces cerevisiae
An11g09700	Catalytic activity: S-adenosyl-L-methionine + uroporphyrin III = S-adenosyl-L-homocysteine + sirohydrochlorin.; Pathway: biosynthesis of sirohemes and cobalamins.; Title: similarity to siroheme synthase cysG -Escherichia coli; See PMID 2407558
An11g09710	Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Title: strong similarity to 4-coumarate-CoA ligase -Populus tremuloides
An11g09720	Function: polyketide synthase PKS1 is required for T-toxin production in Cochliobolus heterostrophus.; Similarity: blastxPATENT hit (p-val=0. 0) to PATENTPROT:R74171 Aspergillus terreus triol polyketide synthase.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776
An11g09730	Function: deoxyriboaldolase is involved in the salvage pathway for nucleosides in Mycoplasma pirum (strain BER).; Title: similarity to deoxyribose-phosphate aldolase SGC3 - Mycoplasma pirum; See PMID 8349569
An11g09740	Complex: S. pombe Crb3 bindins to the R3-region of the replication checkpoint control protein Cut5p in two-hybrid and co-immunprecipitation experiments.; Function: S. pombe Crb3p is an essential protein for viability and may be implicated in the G1/S progression.; Remark: ORF 3'truncated due to end of contig.; Similarity: S. pombe Crb3 is a WD repeat containing protein.; Title: similarity to damage and replication checkpoint control protein crb3p - Schizosaccharomyces pombe [truncated ORF]; See PMID 9407031
An11g09750	Similarity: similarity is from the predicted A. niger protein to the C-terminal half of L. pealeii NF-220 which is 600 aa longer.; Similarity: the location of introns in L. pealeii NF-220 protein shows that it is more closely related to nuclear lamins and type III intermediate-filament proteins than to vertebrate NF proteins.; Title: weak similarity to neurofilament protein NF-220 - Loligo pealei; See PMID 1379729
An11g09760	Function: E. coli lipoate synthase is a homodimer required for the C-S bond formation at nonactivated carbon in the biosynthesis of lipoic acid from octanoic acid.; Function: lipoic acid is a detoxifying molecule due to its metal chelating capacity, its ability to scavenge reactive oxygen species (ROS), its ability to regenerate endogenous antioxidants and its ability to repair oxidative damage.; Function: the S. cerevisiae lip5 mutant is not capable of synthesizing lipoic acid but still possesses the activity necessary for attachment of lipoic acid to protein.; Localization: S. cerevisiae Lip5p contains mitochondrial targeting signals and is required for mitochondrial fatty acid metabolism.; Title: strong similarity to lipoic acid synthase Lip5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8349643; See PMID 9378235; See PMID 11153271
An11g09770	Function: S. cerevisiae Ser2p is required for Serine and glycine biosynthesis in yeast using 3-phosphoglycerate.; Title: strong similarity to phosphoserine phosphatase Ser2 - Saccharomyces cerevisiae; See PMID 1326413
An11g09780	Catalytic activity: PAPS reductases catalyse 5-phosphoadenosine 3-phosphosulfate + reduced thioredoxin <=> phosphoadenosine phosphate + oxidized thioredoxin + sulfite.; Function: involved in sulfate assimilation pathway for biosynthesis of methionine and cysteine.; Remark: 3'-phosphoadenylyl thiosulfotransferases are also called PAPS reductases etc.; Remark: the predicted ORF together with ORF 350cg are homologues to A. terreus and A. nidulans genes involved in the assimilatory reduction of sulfur for the biosynthesis of cysteine and methionine.; Title: strong similarity to 3-phosphoadenylyl thiosulfotransferase sAT - Aspergillus terreus; See PMID 11057445
An11g09790	Catalytic activity: catalyzes the reaction of sulfate and ATP to form adenylylsulfate and pyrophosphate.; Function: ATP sulfurylase is involved in the assimilation of sulfur, that leads to the biosynthesis of methionine and cysteine.; Remark: the predicted ORF together with ORF 360cg are homologues to A. terreus and A. nidulans genes involved in the assimilatory reduction of sulfur for the biosynthesis of cysteine and methionine.; Repression: allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (paps) (by similarity).; Title: strong similarity to sulfate adenylyltransferase sC - Aspergillus nidulans; See PMID 7770049; See PMID 9343344; See PMID 2162344
An11g09820	Remark: Similarity is based on repetitive sequence.; Title: weak similarity to filamentous hemagglutinin fhaB - Bortedella pertussis
An11g09830	Title: weak similarity to hypothetical protein B0280.2 - Caenorhabditis elegans
An11g09840	Title: similarity to polypeptide SEQ ID NO:6214 from patent WO200153312-A1 - Homo sapiens
An11g09850	Remark: Similarity is based on repetitive sequence.; Title: weak similarity to OlpB from patent FR2748479-A1 - Clostridium thermocellum
An11g09860	Function: The determined state of Drosophila imaginal discs depends on stable patterns of homeotic gene expression. The stability of these patterns requires the function of the ash1 gene.; Remark: The ASH1 protein contains a SET domain and a PHD finger. The ASH1 protein is localized on polytene chromosomes of larval salivary glands at > 100 sites.; Similarity: a member of the trithorax group; Title: similarity to protein ash1 - Drosophila melanogaster; See PMID 8725238; See PMID 9663389
An11g09870	Title: similarity to hypothetical protein SPBC3H7.09 - Schizosaccharomyces pombe
An11g09880	Title: similarity to hypothetical protein CAE76201.1 - Neurospora crassa
An11g09890	Catalytic activity: Dolichyl phosphate D-mannose + Protein = Dolichyl phosphate + O-D-Mannosylprotein; Function: Protein mannosylation by Pmt proteins initiates O-glycosylation in fungi; Remark: Mutants defective in PMT1 alleles lacked Pmt in vitro enzymatic activity, showed reduced growth rates,and tended to form cellular aggregates; Title: strong similarity to mannosyltransferase 1 PMT1 - Candida albicans; See PMID 9694829
An11g09900	Complex: mammalian splicing factor SF3a binds to transcription factor Sp1.; Function: mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP into its active form.; Title: similarity to splicing factor SF3a 120K chain - Homo sapiens; nucleus; See PMID 7489498; See PMID 10976766
An11g09910	Function: SEC2 function is required at the post-Golgi apparatus stage of the yeast secretory pathway for the polarized transport of secretory vesicles in S. cerevisiae; Title: strong similarity to protein Sec2 -Saccharomyces cerevisiae; See PMID 10747090; See PMID 1693620
An11g09920	Function: TFAR19 may play a general role in the apoptotic process.; Remark: TFAR19 exhibits a ubiquitous expression pattern and its expression is upregulated in the tumor cells undergoing apoptosis. Overexpression of TFAR19 in tumor cells enhances apoptosis triggered by growth factor or serum deprivation.; Similarity: The human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice.; Title: similarity to protein TFAR19 - Homo sapiens; See PMID 9920759
An11g09930	Remark: Mutant strains harboring mutations in the coq3, coq4, coq5, coq6, coq7, or coq8 genes are unable to produce Ubiquinone.; Title: strong similarity to ubiquinone biosynthesis protein Coq4 - Saccharomyces cerevisiae; See PMID 9266513
An11g09940	Catalytic activity: S-Adenosyl-L-methionine + Histone-L-lysine = S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine.; Title: similarity to histone-lysine N-methyltransferase LSMT - Pisum sativum; See PMID 7888616; See PMID 10593982
An11g09950	Catalytic activity: (r)-pantoate + nadp(+) = 2-dehydropantoate + nadph.; Function: catalyzes the nadph-dependent reduction of ketopantoate into pantoic acid.; Localization: cytoplasmic (potential).; Pathway: alternative pyrimidine biosynthetic (apb) pathway.; Similarity: to ketopantoate reductases from bacteria.; Title: similarity to ketopantoate reductase apbA -Salmonella typhimurium; See PMID 9721324
An11g09960	Remark: C1D encodes a DNA-binding and DNA-PK-activating protein.; Title: weak similarity to DNA-binding protein C1D -Homo sapiens; See PMID 9852280; See PMID 10362552
An11g09970	Title: strong similarity to hypothetical protein YMR002w - Saccharomyces cerevisiae
An11g09980	Function: PspA is a virulence factor of the bacteria that has been shown to protect mice against pneumococcal infection. The amino-terminal part of PspA has been found to be a functional module which is essential for full pneumococcal infectivity.; Remark: Pneumococcal surface protein A (PspA) is one of the major antigens of Streptococcus pneumonia.; Remark: Similarity is based on repetitive sequence.; Title: similarity to pneumococcal surface protein A pspA - Streptococcus pneumoniae; See PMID 10992499; See PMID 11087677
An11g09985	Title: similarity to protein SURF1 - Mus musculus; See PMID 3025660
An11g09990	Title: weak similarity to hypothetical protein encoded by SPBC800.13 - Schizosaccharomyces pombe
An11g10000	Title: similarity to hypothetical protein SPBC23G7.07c - Schizosaccharomyces pombe
An11g10010	Title: similarity to hypothetical protein encoded by An16g04370 - Aspergillus niger
An11g10020	Similarity: Similarity is based on repetitive sequences.; Title: similarity to wound-responsive protein KED -Nicotiana tabacum; See PMID 10945337
An11g10030	Title: strong similarity to hypothetical rac GTPase AAD50299.1 - Xenopus laevis
An11g10050	Function: The Leu3 protein of yeast is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: Yeast zinc cluster proteins form a major class of yeast transcriptional regulators. They usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. Orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein . Leu3p, also recognize CGG triplets but when oriented in opposite directions, an everted repeat.; Similarity: Leu3p, belongs to the family of Zn(II)2Cys6 proteins.; Title: similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402
An11g10060	Title: strong similarity to hypothetical GTPase activating protein GAP1 - Cochliobolus heterostrophus
An11g10070	Title: weak similarity to hypothetical protein SPAC13G7.11 - Schizosaccharomyces pombe
An11g10080	Title: weak similarity to hypothetical protein CAE76369.1 - Neurospora crassa
An11g10090	Function: additional factor that functions in concert with eif-2 and the initiator trna in directing the ribosome to the proper start site of translation.; Remark: evidence for direct interaction between rent2 and human eIF4AI and Sui1, both are components of the translation initiation complex.; Similarity: belongs to the sui1 family.; Title: strong similarity to translation factor sui1p - Schizosaccharomyces pombe; See PMID 11073994
An11g10100	Title: strong similarity to hypothetical protein EAA60784.1 - Aspergillus nidulans
An11g10110	Function: Srb/mediator proteins that are associated with RNA polymerase II holoenzyme have been implicated in transcriptional repression in S. cerevisiae; Remark: The products of all nine SRB genes identified are components of the RNA polymerase II holoenzyme.; Title: similarity to protein Srb8 - Saccharomyces cerevisiae; nucleus; See PMID 7774808; See PMID 9755175
An11g10120	Induction: Expression of the qid3 gene is derepressed in the absence of glucose.; Localization: QID3 is encoding a putative cell wall protein.; Remark: When introduced in yeast, qid3 expression causes cell division arrest into cytokinesis and cell separation, probably due to its cell wall localization.; Similarity: belongs to hydrophobin HFBI superfamily.; Title: weak similarity to QID3 - Trichoderma harzianum; See PMID 8121402
An11g10130	Title: similarity to hypothetical protein T29A15.10 - Arabidopsis thaliana
An11g10140	Function: CIA30 is a novel chaperone specific for complex I membrane arm assembly.; Title: strong similarity to NADH:ubiquinone reductase intermediate-associated protein CIA30 -Neurospora crassa; See PMID 9769214
An11g10150	Catalytic activity: ATP + 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole + L-Aspartate = ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imi dazole; Function: involved in purine biosynthesis.; Induction: The promoter of the ADE1 gene contains a copy of the 5'-TGACTC hexanucleotide, a feature characteristic of promoters under general aa control.; Pathway:The ade4, ade5, ade8, ade6, and ade7 mutations were found to suppress the phenotypic manifestation of the ade2 mutations via inactivation of enzymes catalyzing the first, second, third, fourth and fifth stages of purine biosynthesis, while the ade1 mutation, which inactivates enzyme of the seventh stage,lacks suppressive activity.; Remark: Strains with single adenine mutations, ade4,ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media.; Title: strong similarity to phosphoribosylaminoimidazolesuccinocarboxamide synthase Ade1 - Saccharomyces cerevisiae; See PMID 1756975
An11g10160	Function: oxetanocin A selective inhibits the replication of several viral particles,like the human cytomegalovirus.; Remark: Bacillus megaterium strain NK84-0218 produces a potent antiviral nuclesosid, oxetanocin A, which has an oxetanosyl-N-glycoside linkage to an adenine moiety.; Title: strong similarity to hypothetical oxetanocin A resistance protein oxrB - Bacillus megaterium; See PMID 10227144
An11g10180	Remark: the G. zeae mating-type protein MAT 1-1 is a member of the proteins controling the reproductive mode of G. zeae, G. fujikuroi and the asexual F. oxysporum.; Title: similarity to mating type protein MAT1-1-1 -Gibberella zeae; See PMID 11118131
An11g10190	Function: APN2 of S. cerevisiae contains both 3'-phosphodiesterase activity and 3'->5' exonuclease activity and has a role in the repair of H(2)O(2)-induced DNA damage.; Remark: APN2 of S. cerevisiae is also known as ETH1 and YBL019W.; Similarity: APN2 of S. cerevisiae is a member of the class II AP endonucleases.; Title: similarity to apurinic/apyrimidinic (AP) endonuclease Apn2 - Saccharomyces cerevisiae; See PMID 9765213; See PMID 10806210; See PMID 11238902
An11g10200	Function: subunit of the cytochrome c oxidase, the final component of the respiratory chain, that catalyzes the electron transfer from cytochrome c to oxygen.; Title: strong similarity to subunit VIa of cytochrome c oxidase Cox13 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8395517
An11g10210	Complex: the human anaphase-promoting complex is composed of eight protein subunits (BimE/APC1, CDC27/APC3,CDC16/APC6, CDC23/APC8, APC2, APC4, APC5, and APC7).; Function: human anaphase-promoting complex has E3-ubiquitin ligase activity and controls all postmetaphase events.; Title: similarity to anaphase-promoting complex subunit APC5 - Homo sapiens; See PMID 9469815; See PMID 10872461
An11g10250	Remark: the human GS1 protein is encoded by a gene that is of interest because it is one of the few X-linked genes that escapes X-inactivation.; Title: strong similarity to cDNA GS1 - Homo sapiens; See PMID 1284467
An11g10260	Golgi; Remark: K. lactis alphaN-acetylglucosamine transferase is predicted to be a Golgi membrane transporter, who tranfers UDP-GlcNAc into the lumen, where it is a substrate in the biosynthesis of mannoproteins.; Title: strong similarity to alphaN-acetylglucosamine transferase - Kluyveromyces lactis; See PMID 8650202
An11g10270	Title: strong similarity to aspartic protease polypeptide #4 from patent WO200268623-A2. - Aspergillus niger
An11g10280	Remark: the P. anserina het-e-1 gene of the fungus Podospora anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Title: weak similarity to beta-transducin like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787
An11g10290	Catalytic activity: E. coli betaine-aldehyde dehydrogenase converts betaine aldehyde and NAD(+)and H(2)O to betaine and NADH.; Complex: betB of E. coli exists as a homotetramer.; Pathway: E. coli betaine-aldehyde dehydrogenase is part of the glycine, serine and threonine metabolism.; Remark: E. coli betaine-aldehyde dehydrogenase belongs to the superfamiliy of oxidureductases.; Title: strong similarity to betaine-aldehyde dehydrogenase betB - Escherichia coli; See PMID 2194570; See PMID 1956285
An11g10300	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAD16864.1 - Ralstonia solanacearum
An11g10310	Complex: the P. acaligenes GDO structure is deduced to be a tetramer.; Induction: the P. alcaligenes GDO can be induced through 3-hydroxybenzoate.; Similarity: hte P. alcaligenes belongs to the cupin superfamily, which are functionally diverse proteins that share a highly conserved pattern of two histidine-containing motifs with a varied intermotif spacing.; Title: similarity to gentisate 1,2-dioxygenases GDO - Pseudomonas alcaligenes; See PMID 10049846
An11g10320	Function: the S. cerevisiae SLA2 protein is required for cellular morphogenesis and polarization of cortical cytoskeleton.; Remark: SLA2 of S. cerevisiae is also known as END4,MOP2 and YNL243W.; Similarity: the C-terminal part of the predicted A. niger protein shows strong similarity to the C-terminal part of the human Talin TLN protein, which is a cytoskeletal focal adhesion protein.; Title: strong similarity to cytoskeleton assembly control protein homolog Sla2 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8335689
An11g10330	Remark: an alternative name for the predicted S. cerevisiae protein is P9513. 15.; Title: strong similarity to hypothetical membrane protein YPR091c - Saccharomyces cerevisiae
An11g10340	Similarity: the ORF encoded protein shows also weak similartity to hypothetical protein VC1974 from Vibrio cholerae (strain N16961).; Title: strong similarity to hypothetical protein encoded by An02g00110 - Aspergillus niger
An11g10350	Remark: the C. albicans gene was isolated through complementation of the complementation of fluconazole hypersusceptibility in S. cerevisiae YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the deduced amino acid sequence of FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An11g10370	Catalytic activity: S. cerevisiae trans-pentaprenyltranstransferase converts All-trans-pentaprenyl diphosphate and isopentenyl diphosphate to diphosphate and all-trans-hexaprenyl diphosphate.; Function: S. cerevisiae trans-pentaprenyltranstransferase is involved in the CoenzymeQ biosythesis. Coenzyme Q (Ubichinone) is involved in the synthesis of ATP and is an antioxydant.; Remark: the systematical name for the S. cerevisiae COQ1 protein is YBR003W.; Title: strong similarity to trans-pentaprenyltranstransferase Coq1 - Saccharomyces cerevisiae; See PMID 2198286
An11g10380	Function: The 26S proteasome is the multiprotein complex that degrades proteins that have been marked for destruction by the ubiquitin pathway.; Title: strong similarity to 26S proteasome regulatory subunit rpn3p - Schizosaccharomyces pombe; See PMID 10582238
An11g10400	Function: TAF61 of S. cerevisiae has a role in RNA polymerase II transcription where it is required by Gcn4 to recruit the SAGA coactivator complex.; Remark: TAF61 of S. cerevisiae is also known as TAFII61 and YDR145W.; Similarity: the similarity of the ORF to the S. cerevisiae TAF61 is restricted to the C-terminal region, as the ORF is 443 aa longer at the N-terminus.; Title: similarity to subunit of transcription initation factor TFIID Taf61 - Saccharomyces cerevisiae; See PMID 8962109; See PMID 9844640
An11g10410	Function: phosphatidylinositol-5-kinase catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate. phosphatidylinositol 4, 5-bisphosphate is a precursor of diacylglycerol and inositol 1,4,5-trisphosphate, which are important second messengers.; Pathway: S. pombe phosphatidylinositol-5-kinase is thought to be regulated by phosphorylation via casein kinase 1 Cki1.; Title: strong similarity to phosphatidylinositol-4-phosphate 5-kinase -Schizosaccharomyces pombe; plasma membrane; See PMID 9873063
An11g10420	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An11g10430	Function: histone H1, similar to H5, normally acts as linker histone connecting nucleosomes to form the 30-nm chromatin fiber.; Localization: an H1-GFP fusion shows exclusive nuclear localization, whereas chromosomal localization can be observed during condensation at mitosis.; Phenotype: deletion of the hhoa gene of A. nidulans results in no obvious phenotype: nucleosomal repeat length and susceptibility to micrococcal nuclease digestion remained unaffected as well as the nucleosomal organization of a number of promoters.; Similarity: hhoa of A. nidulans belongs to the histone H1/H5 family.; Similarity: the A. niger EST an_2114 in EMBLEST:BE759338 overlaps with the ORF.; Similarity: the A. niger Nig013 in EMBLEST:AN732 overlaps with the ORF.; Title: strong similarity to histone H1 hhoA -Aspergillus nidulans; nucleus; See PMID 10984712; See PMID 11149891
An11g10440	Remark: unusual intron/exon structure for A. niger and short length (102 amino acids).; Title: questionable ORF
An11g10450	Catalytic activity: Rad2p possesses a 5'-->3' single-stranded exonuclease activity.; Function: the rad2 protein of S. pombe is essential for repair of DNA damage after UV-irradiation.; Function: the rad2 protein of S. pombe is involved in Okazaki fragment processing (DNA replication).; Function: the rad2 protein of S. pombe is involved in the fidelity of chromosome segregation.; Phenotype: the rad2 mutant of S. pombe has additionally a very high degree of chromosome loss and/or nondisjunction.; Phenotype: the rad2 mutant of S. pombe is deficient in the repair of UV damage.; Remark: the rad2 protein of S. pombe is also called SPAC3G6. 06C and FEN1 (flap endonuclease 1).; Similarity: rad2 of S. pombe belongs to the rad2(pombe)/FEN1 subfamily.; Title: strong similarity to DNA repair protein rad2p - Schizosaccharomyces pombe; nucleus; See PMID 8007985; See PMID 10908351
An11g10460	Function: prnA of A. nidulans controls the expression of the prn gene cluster, which is necessary for proline utilization as a nitrogen and/or carbon source.; Similarity: the A. niger EST clone 0700 in EMBLEST:BE760806 overlaps with the ORF at the ORF's C-terminus.; Similarity: the ORF shows only local (N-terminal,until amino acid 388) homology to the prnA protein of A. nidulans.; Similarity: the ORF shows similarity to other transcription factors/transcriptional regulators too.; Similarity: the ORF shows weak similarity to A. niger mutant prtT allele polypeptide prt13 from patent WO200020596-A1.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360
An11g10470	Catalytic activity: GCHD of H. sapiens catalyzes the oxidative carboxylation of glutaryl-CoA to crotonyl-CoA.; Complex: GCDH of H. sapiens is a subunit of a homotetramer.; Function: GCHD of H. sapiens functions in the degradation of lysine, hydroxylysine, and tryptophan (EC: 1. 3. 99. 7).; Localization: GCHD of H. sapiens is localized to the mitochondrial matrix.; Phenotype: deficiency of GCDH in H. sapiens leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease.; Remark: GCHD of H. sapiens belongs to the acyl-CoA dehydrogenase family.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF shows also strong similarity to acyl-CoA dehydrogenases of several species (EC: 1. 3. 99. 3).; Title: strong similarity to glutaryl-CoA dehydrogenase GCHD - Homo sapiens; See PMID 8541831; See PMID 9600243
An11g10480	Remark: unusual exon/intron structure for A. niger and short length (75 amino acids).; Title: questionable ORF
An11g10490	Catalytic activity: UBC4 of S. cerevisiae converts ATP + ubiquitin + protein lysine to AMP + pyrophosphate + protein N-ubiquityllysine.; Function: UBC4 of S. cerevisiae catalyzess the covalent attachment of ubiquitin to other proteins,mediating the selective degradation of short-lived and abnormal proteins.; Function: UBC4 of S. cerevisiae contributes to a major portion of the ubiquitin-dependent protein degradation in stressed cells.; Title: strong similarity to ubiquitin conjugating enzyme Ubc4 - Saccharomyces cerevisiae; cytoplasm; See PMID 1311250; See PMID 1651925; See PMID 2154373; See PMID 8381213; See PMID 8391479
An11g10500	Similarity: the indicated EST extends further along the putative 3'-UTR of the predicted gene.; Title: strong similarity to EST an_2112 -Aspergillus niger
An11g10510	Function: SRPK2 of M. musculus is involved in the control by phosphorylation of SR splicing factors.; Similarity: the main feature of the predicted ORF is to contain a serine-threonine protein kinase domain; this explains the huge number of BLASTP hits to known and putative members of this broad protein family.; Title: similarity to serine/arginine-rich protein-specific kinase SRPK2 - Mus musculus; See PMID 9446799
An11g10520	Similarity: many other BLASTP hits are due to the relative high content of Ser and Ala.; Similarity: the similarity to the R. capsulatus hypothetical protein involves only the N-terminal fifth of the protein.; Title: similarity to hypothetical conserved protein - Rhodobacter capsulatus
An11g10540	Function: mra1 of S. pombe is essential for cell growth and in promoting the mating function; it may be a factor constituting a third pathway regulated by ras1.; Title: strong similarity to ras-associated protein mra1p - Schizosaccharomyces pombe; See PMID 9133664
An11g10550	Title: questionable ORF
An11g10560	Function: eso1 of S. pombe is essential for the establishment of sister chromatid cohesion during S phase.; Function: eso1 of S. pombe plays a dual role during DNA replication: the C-terminal region acts to establish sister chromatid cohesion, and the N-terminal region presumably catalyzes translesion DNA synthesis when template DNA contains lesions that block regular DNA replication.; Localization: eso1 of S. pombe is probably a nuclear protein.; Similarity: the similarity to eso1 of S. pombe involves only the C-terminal regions of the two proteins.; Title: similarity to sister chromatid cohesion protein eso1p - Schizosaccharomyces pombe; See PMID 10779336
An11g10570	Remark: C-terminally truncated ORF due to contig border.; Similarity: the similarity to the cell wall protein of Y. lipolytica and other proteins is mainly due to low complexity and repetitive elements.; Title: weak similarity to cell wall protein -Yarrowia lipolytica [truncated ORF]; See PMID 8972576
An11g10580	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: N-terminally truncated due to contig border.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611
An11g10600	Remark: sucrose transport by SUT1 is linked to the proton electrochemical potential across the plasma membrane.; Title: strong similarity to sucrose-proton transport protein SUT1 - Daucus carota; plasma membrane; See PMID 9847123
An11g10610	Catalytic activity: catalyzes the alpha-glucosylation of itself on a specific tyrosine residue by UDP-glucose to produce glucosyl-glycogenin and UDP; catalyzes the subsequent alpha-1,4-glucosylation of glucosyl-glycogenin by UDP-glucose to produce glycogen and UDP.; Pathway: the enzyme is involved in glycogen/starch biosynthesis.; Title: similarity to glycogenin glucosyltransferase - Oryctolagus cuniculus; See PMID 1281472; See PMID 3121316
An11g10620	Title: weak similarity to membrane-associated proteophosphoglycan - Leishmania major
An11g10630	Complex: the human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with the large subunit p170.; Remark: eukaryotic initiation factor 3 (eIF3) is a large multisubunit complex that stabilizes the ternary complex, eIF2 x GTP x tRNA(Met)i and promotes mRNA binding to the 40 S ribosomal subunit.; Title: similarity to translation initiation factor 3 complex protein Prt1 - Homo sapiens; See PMID 8995410
An11g10650	Protein sequence is in conflict with the conceptual translation; putative frameshift
An11g10660	Function: the bimE gene product is a novel component in the regulation of mitosis.; Phenotype: bimE mutations both cause cells to enter mitosis and prevent them from leaving mitosis.; Title: strong similarity to cell cycle control protein bimE - Aspergillus nidulans; See PMID 1697851
An11g10670	Title: strong similarity to sequence 7 from patent WO0075305 - Candida albicans
An11g10680	Remark: similarity to extensin-like proteins, which is based mainly on prolines.; Title: weak similarity to largest subunit of DNA-directed RNA polymerase II RPB1 - Mastigamoeba invertens
An11g10690	Function: EMK1 is a mitogen-activated protein kinase kinase required for induction of cytokinesis and appressorium formation by host signals in the conidia of Colletotrichum gloeosporioides.; Phenotype: disruption of EMK1 results in the loss of its ability to form appressoria in response to the host's signals and a loss of virulence.; Remark: Colletotrichum gloeosporioides is synonymous with Glomerella cingulata.; Title: strong similarity to MAP kinase kinase EMK1 -Glomerella cingulata; See PMID 10948253
An11g10710	Function: SPT6 influences the expression of many genes through effect on chromatin structure.; Function: SPT6 modifies the chromatine structure.; Function: SPT6is involved in transcription elongation.; Remark: truncated ORF due to contig border.; Similarity: shows similarity to the same gene of different species and to several hypothetical proteins.; Title: similarity to transcription elongation protein Spt6 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 9450930
An11g10720	Function: might be involved in sterol synthesis and/or its regulation.; Remark: contains a domain typical for oxysterol-binding proteins.; Similarity: shows similarity to protein that might be involved in sterol synthesis.; Title: strong similarity to hypothetical protein YHR073w - Saccharomyces cerevisiae
An11g10730	Title: strong similarity to hypothetical protein SPBC20F10.03 - Schizosaccharomyces pombe
An11g10740	Function: protein of S. cerevisiae is involved in 3'-end processing of the 5. 8S rRNA.; Title: strong similarity to 3-5 exoribonuclease required for 3-end formation of 5.8S rRNA Rrp4 -Saccharomyces cerevisiae; nucleus; See PMID 8600032; See PMID 9463390; See PMID 9482746
An11g10750	Similarity: blast hits result from repetitive sequences.
An11g10760	Function: NRS1 is involved in processing 20S to 18S rRNA.; Function: proteins containing RNP consensus-sequence RNA-binding domains (CS-RBDs) play diverse roles in many aspects of RNA metabolism.; Similarity: shows strong similarity to known protein of S. cerevisiae nuclear localization sequence binding protein NSR1.; Title: strong similarity to RNA-binding protein rnp24p - Schizosaccharomyces pombe; See PMID 8598051
An11g10770	Title: strong similarity to hypothetical conserved protein B8L3.80 - Neurospora crassa
An11g10780	Function: might be involved in transcriptional regulation as it is a zinc-finger protein.; Remark: the ORF is truncated due to the border of the contig.; Similarity: no similarity at the aminoterminal part.; Title: similarity to hypothetical conserved protein B8L3.060 - Neurospora crassa [truncated ORF]
An11g10790	Function: PON2 catalyzes the hydrolysis of toxic organophosphates.; Function: the absence of paraoxonase activity in turkey and chicken blood and turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon.; Localization: PON2 is an extracellular enzyme.; Similarity: shows strong similarity to probable arylesterase of N. crassa.; Title: similarity to serum paraoxonase/arylesterase 2 PON2 - Gallus gallus
An11g10800	Function: isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase catalyses the conversion of isochorismate, in the presence of water, to 2, 3-dihydroxybenzoate and pyruvate.; Similarity: belongs to a family of hydrolase enzymes.; Title: similarity to hypothetical isochorismatase Ta0729 - Thermoplasma acidophilum
An11g10810	Title: similarity to hypothetical protein B13D24.020 - Neurospora crassa
An11g10820	Function: might be a sensor/regulator protein harboring pac and pas domains.; Function: wc-1 gene expression is autoregulated and is transcriptionally induced by blue light irradiation.; Function: wc-1 zinc finger domain is able to bind specifically to the promoter of a blue light-regulated gene of Neurospora.; Similarity: shows similarity to central and carboxyterminal part of wc-1.; Title: similarity to central regulator of blue light responses wc-1 - Neurospora crassa
An11g10830	Similarity: shows only partial similarity to X. laevis protein.; Title: weak similarity to Ig mu chain C region -Xenopus laevis
An11g10840	Function: Ras-cyclic AMP pathway is required for the formation of hyphae in Y. lipolytica.; Function: protein of Y. lipolytica is homologous to S. cerevisiae RAS2.; Title: strong similarity to GTPase Ras2p - Yarrowia lipolytica; See PMID 11325938
An11g10870	Title: strong similarity to gene expression regulator An13 from patent WO200257456-A2 - Unclassified organism
An11g10890	Function: Aldose 1-epimerase is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms.; Remark: It has also been shown that, on the basis of extensive sequence similarities, a mutarotase domain seem to be present in the C-terminal half of the fungal GAL10 protein which encodes, in the N-terminal part, for UDP-glucose 4-epimerase.; Similarity: shows partial similarity to carboxyterminal part of the enzyme of S. cervisiae harboring the Aldose 1-epimerase domain.; Title: similarity to UDP-glucose 4-epimerase Gal10 -Saccharomyces cerevisiae; cytoplasm; See PMID 7762304; See PMID 9335593
An11g10910	Catalytic activity: Nicotinate D-ribonucleotide + diphosphate + CO(2) <=> pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate; Function: the H. sapiens homolog QPRTase is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.; Title: strong similarity to nicotinate-nucleotide pyrophosphorylase (carboxylating) QPRTase - Homo sapiens
An11g10920	Function: the A. nidulans homolog aspB is an essential gene that encodes a septin, putative cytoskeletal proteins involved in cytokinesis and morphogenesis. aspB affects nuclear distribution in hyphae and specifically blocks conidiophore development at the metula stage when mutant.; Similarity: most fungal septins belong to one of four orthologous classes.; Title: strong similarity to septin apsB -Aspergillus nidulans; See PMID 9126618
An11g10930	Function: the H. sapiens homolog p200 ARF-GEP1 is a guanine nucleotide-exchange protein (GEP) which activates ADP-ribosylation factors (ARFs), approximately 20-kDa guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking, through accelerated replacement of bound GDP with GTP.; Golgi; Repression: Human p200 ARF-GEP1 is inhibited by brefeldin A (BFA), a fungal metabolite that blocks protein secretion and causes apparent disintegration of the Golgi structure.; Similarity: H. sapiens p200 ARF-GEP1 is a ubiquitously expressed guanine nucleotide exchange factor of the Sec7 domain family, which affects protein traffic and Golgi morphology.; Title: strong similarity to p200 protein ARF-GEP1 -Homo sapiens
An11g10950	Function: R. norvegicus UNCL is a RNA binding transmembrane protein.; Similarity: the R. norvegicus homolog UNCL shows homologies C. elegans unc-50 gene product.; Title: strong similarity to unc-50 related protein UNCL - Rattus norvegicus; nucleus
An11g10960	Title: weak similarity to protein fragment SEQ ID NO:13312 from patent EP1033405-A2 - Arabidopsis thaliana
An11g10970	Function: MCTs are needed for rapid transport of monocarboxylates such as lactate and pyruvate.; Similarity: the ORF shows similarity to several carboxylate transporters.; Similarity: the closest homolog of the ORF, the S. cerevisiae YOR306c protein, encodes one of four putative monocarboxylate transporters (MCTs) in the yeast genome.; Title: similarity to monocarboxylate transporter MCT2 - Mesocricetus auratus
An11g10990	Catalytic activity: Trehalose 6-phosphate + H(2)O <=> trehalose + phosphate.; Complex: the S. cerevisiae homolog TPS2 encodes the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex.; Function: S. cerevisiae TPS2 codes for the structural gene of the trehalose-6-phosphate phosphatase.; Induction: S. cerevisiae Tps2p expression is induced under heat-shock conditions.; Pathway: trehalose biosynthesis.; Title: strong similarity to trehalose-6-phosphate phosphatase TPP from patent WO200116357-A2 - Saccharomyces cerevisiae
An11g11000	Function: the H. sapiens homolog TRF4 is required for sister chromatid cohesion and encodes a DNA polymerase with beta-polymerase-like properties.; Title: similarity to DNA polymerase kappa TRF4 -Homo sapiens; nucleus
An11g11010	Catalytic activity: a phosphatidylcholine + H(2)O <=> choline + a phosphatidate.; Function: The activation of phospholipase D (PLD) is believed to play an important role in the regulation of cell function and cell fate. The function of the S. cerevisiae homolog Pld1p, while essential for meiosis, is dispensable for vegetative growth.; Localization: different PLD isoforms are localized in distinct cellular organelles, where they are likely to serve diverse functions in signal transduction, membrane vesicle trafficking and cytoskeletal dynamics.; Remark: an alternative gene name for the S. cerevisiae homolog PLD1 is SPO14.; Similarity: the homolog Pld1p is sole member of the phosphatidylcholine-specific phospholipase D gene family in S. cerevisiae.; Title: strong similarity to phospholipase D Pld1 -Saccharomyces cerevisiae
An11g11020	Title: strong similarity to hypothetical protein 12F11.200 - Neurospora crassa
An11g11030	Phenotype: mutations in L28 of S. cerevisiae can lead to resistance to cycloheximide, an inhibitor of eukaryotic protein synthesis.; Remark: L28 of S. cerevisiae is also called L28,CYH2, G3101, YGL103w, or YL29.; Similarity: the ORF overlaps with the A. niger EST seq id no:3836 of patent WO200056762-A2.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L28 - Saccharomyces cerevisiae; cytoplasm; See PMID 6304624
An11g11040	Function: the S. cerevisiae homolog CHL1 is a helicase required for maintenance of the high fidelity of chromosome transmission during mitosis and wild-type levels of meiotic recombination as well as spore viability.; Title: strong similarity to helicase Chl1 -Saccharomyces cerevisiae; nucleus
An11g11050	Function: SKT5 of S. cerevisiae is an enzyme activator involved in the cell wall chitin biosynthesis probably by acting as a post-translational regulator of chitin synthase III activity, and seems to influence cytokinesis as well as osmotic response.; Function: SKT5 of S. cerevisiae is involved in protoplast regeneration and killer toxin resistance.; Remark: SKT5 of S. cerevisiae is also called CAL2,CHS4, CSD4 or YBL061C.; Similarity: the ORF is 93 amino acids shorter at the N-terminus than SKT5 of S. cerevisiae and the homology is restricted to the inner part of both proteins.; Title: strong similarity to enzyme activator protein Skt5 - Saccharomyces cerevisiae; See PMID 1532231; See PMID 7764021; See PMID 8257107
An11g11060	Function: meu13 of S. pombe is believed to be a molecule that is required for proper homologous chromosome pairing during meiosis by contributing to pairing through a recombination-independent mechanism.; Remark: meu13 of S. pombe is also called SPAC222. 15 or SPAC821. 01.; Similarity: additionally, the ORF shows similarity to TBP-1 interacting protein of M. musculus.; Similarity: the ORF overlaps with A. niger EST SEQ ID NO:4271, database PATENTDNA:AAF11748.; Title: similarity to meiosis-specific protein meu13p - Schizosaccharomyces pombe; nucleus; See PMID 11447128
An11g11070	Remark: the S. pombe homolog scp3 is related to spindle poison sensitivity.; Title: strong similarity to hypothetical protein scp3p - Schizosaccharomyces pombe
An11g11080	Function: S. cerevisiae Rsc1p is subunit of the RSC-complex, an essential 15 protein nucleosome-remodeling complex, and is required for transcriptional control.; Remark: an alternative gene name for the S. cerevisiae homolog RSC1 is YGR056w.; Title: strong similarity to protein Rsc1 -Saccharomyces cerevisiae; nucleus
An11g11090	Title: strong similarity to hypothetical protein SPAC24C9.14 - Schizosaccharomyces pombe
An11g11100	Function: S. pombe hsk1 is required for G1/S transition.; Remark: shows strong similarity to cell cycle protein kinase hsk1 - Schizosaccharomyces pombe.; Title: strong similarity to cell cycle protein kinase hsk1p - Schizosaccharomyces pombe
An11g11110	Complex: is part of the five-member condensin complex, each of which is essential for mitotic condensation.; Title: strong similarity to condensin complex component cnd1p - Schizosaccharomyces pombe
An11g11120	Similarity: the S. pombe homolog SPBC646. 08c has similarity to proteins involved in ergosterol biosynthesis.; Title: strong similarity to hypothetical protein involved in ergosterol biosynthesis SPBC646.08c -Schizosaccharomyces pombe
An11g11130	Complex: S. pombe UCH is associated with the proteasome by its C-terminal extension.; Function: the S. pombe homolog UCH belongs to the family of deubiquitinating enzymes (DUBs) and encodes a ubiquitin carboxyterminal hydrolase.; Title: strong similarity to 26S proteasome-associated ubiquitin carboxyl-terminal hydrolase uch2p - Schizosaccharomyces pombe
An11g11140	Complex: S. cerevisae Pom152 is part of the nuclear pore complex (NPC).; Function: the S. cerevisiae homolog Pom152p is an abundant but nonessential nucleoporin.; Localization: S. cerevisiae Pom152p is a type II integral membrane protein with N-terminal region on pore side and C-terminal region in the cisternae.; Title: strong similarity to nuclear pore membrane protein Pom152 - Saccharomyces cerevisiae; nucleus
An11g11150	Remark: the S. cerevisiae homolog YGR090w is an essential gene.; Title: strong similarity to hypothetical protein YGR090w from patent WO200039342-A2 - Saccharomyces cerevisiae
An11g11160	Catalytic activity: O-succinyl-L-homoserine + L-cysteine <=> cystathionine + succinate.; Complex: the N. crassa homolog met-7+, together with met-3+, is required to form a functional cystathionine-gamma-synthase (CGS).; Function: CGS catalyses the first reaction specific for methionine biosynthesis.; Title: strong similarity to O-succinylhomoserine (thiol)-lyase met-7 chain - Neurospora crassa
An11g11170	Function: the S. cerevisiae homolog YmL20 encodes for a mitochondrial large subunit ribosomal protein.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml20 - Saccharomyces cerevisiae; localisation:mitochondrion
An11g11180	Similarity: the ORF encoded protein shows strong similarity to expressed sequence tag an_3583 from Aspergillus niger.; Title: strong similarity to hypothetical protein encoded by SPBC1198.08 - Schizosaccharomyces pombe
An11g11190	Function: the S. pombe homolog rad18p is involved in both UV-induced lesions and double-stranded breaks. Furthermore rad18p is required to maintain cell cycle arrest in the presence of DNA damage, and failure of this leads to highly aberrant mitoses.; Title: strong similarity to DNA repair protein rad18p - Schizosaccharomyces pombe
An11g11210	Function: the S. pombe homolog ste13 encodes a RNA helicase that is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development.; Title: strong similarity to ATP-dependent RNA helicase ste13p - Schizosaccharomyces pombe; nucleus
An11g11230	Function: CTP1 from S. cerevisiae is involved in citrate transport across the inner mitochondrial membrane.; Remark: strong similarity to Acetyl CoA transport protein orf14 of patent WO200037629-A2.; Similarity: the ORF encoded protein shows also strong similarity to expressed sequence tag seq id no:3910 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to citrate transport protein Ctp1 - Saccharomyces cerevisiae; localisation:mitochondrion
An11g11240	Function: the K. lactis homolog MRF1 encodes the mitochondrial peptide chain release factor mRF-1 which is involved in termination of mitochondrial protein synthesis.; Title: strong similarity to translation releasing factor RF-1 precursor MRF1 - Kluyveromyces lactis; localisation:mitochondrion
An11g11250	Function: P58 from H. sapiens is a cellular protein that is activated during influenza virus infection to down-regulate the activity of PKR.; Similarity: the ORF encoded protein shows also strong similarity to expressed sequence tag an_2388 from Aspergillus niger.; Title: strong similarity to interferon-induced double-stranded RNA-activated protein kinase inhibitor P58 - Homo sapiens; See PMID 8666242
An11g11260	Catalytic activity: S-adenosyl-L-methionine + protein L-beta-aspartate <=> S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.; Function: the M. musculus homolog PCMT1 encodes a D-aspartate O-methyltransferase which is involved in protein methylation.; Title: strong similarity to protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 - Mus musculus
An11g11280	Catalytic activity: Succinyl-CoA + dihydrolipoamide <=> CoA + S-succinyldihydrolipoamide.; Function: the S. cerevisiae homolog Kgd2p is a subunit of the 2-oxoglutarate dehydrogenase (alpha-ketoglutarate dehydrogenase) complex KE2. KE2 catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa & co2.; Remark: strong similarity to dihydrolipoamide succinyltransferase Kgd2p - S. cerevisiae.; Title: strong similarity to dihydrolipoamide succinyltransferase kgd2 - Aspergillus fumigatus; localisation:mitochondrion
An11g11290	Title: similarity to hypothetical protein CX157 -Homo sapiens
An11g11300	Gene-ID: httA; Similarity: shows strong similarity to superfamily of histone H2A proteins.; nucleus
An11g11310	Similarity: shows strong similarity to superfamily of histone H2B proteins.; Similarity: the ORF shows strong similarity to expressed sequence tag an_2054 from Aspergillus niger.; Title: strong similarity to histone H2B -Aspergillus nidulans; See PMID 2274040
An11g11320	Complex: Aut2p and Aut7p interact physically. Aut7p is attached to microtubules via Aut2p, which interacts with tubulins Tub1p and Tub2p.; Function: Aut2p is a member of a ubiquitin-like system required for the autophagy and cytoplasm to vacuole targeting pathways. Aut2p has a proteolytic activity and activates the ubiquitin-like modifyer Aut7p by cleaving the carboxy-terminal arginine of nascent Aut7p.; Remark: alternative gene names for the S. cerevisiae homolog AUT2 are APG4 and YNL223w.; Title: strong similarity to protein involved in autophagy Aut2 - Saccharomyces cerevisiae; cytoplasm
An06g00010	Remark: ORF 5'truncated due to end of contig.; Similarity: Regionally restricted similarity to ankyrin from many organisms.; Title: similarity to polypeptide SEQ ID NO:13410 from patent WO200171042-A2 - Drosophila melanogaster
An06g00020	Similarity: Similarity to a short sequence motif from glutamate-5-semialdehyde dehydrogenase (EC 1. 2. 1. 41) Corynebacterium glutamicum.
An06g00030	Title: similarity to hypothetical protein C29F5.1 -Caenorhabditis elegans
An06g00040	Title: questionable ORF
An06g00050	Similarity: Similarity to a short sequence region of acz gene for aczonin from Homo sapiens.
An06g00060	Similarity: Similarity to other proteins is based on repetetive sequence regions.
An06g00090	Function: Tto1 can transpose autonomously through reverse transcription.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443
An06g00110	Similarity: Weak similarity to parts of a hypothetical urea active transporter from Schizosaccharomyces pombe.
An06g00120	Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism
An06g00130	Catalytic activity: NADH + acceptor = NAD(+) + reduced acceptor.; Cofactor: This flavoprotein enzyme contains one noncovalently bound FAD per polypeptide chain.; Function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation.; Induction: Expressed aerobically and repressed in fermentation.; Localization: Membrane.; Similarity: the ORF shows similarity to several different reductases.; Title: similarity to NADH dehydrogenase ndh -Escherichia coli; See PMID 7020757; See PMID 6265208
An06g00150	Similarity: Most blast hits are due to repetetive sequence elements.; Similarity: Some blast hits to mucins.; Title: similarity to hypothetical protein encoded by An11g04090 - Aspergillus niger
An06g00160	Remark: binB is induced by the antibiotic bafilomycin.; Title: weak similarity to hypothetical cell wall protein binB - Aspergillus nidulans
An06g00170	Function: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides,including galactose oligosaccharides, galactomannans and galactolipids.; Gene-ID: aglA; Mapping: aglA from A. niger is mapped to chromosome VIII (LG VIII); see list from DSM, PUBMED 8041364.; Remark: This ORF has some differences in its nucleotide sequence compared to aglA from the databanks resulting in some aa exchanges.; Remark: This ORF is N-terminally 8 aa shorter than aglA from the databanks.; Remark: in the SWISSPROT entry P56526 the alpha-glucosidases aglU from A. niger is also wrongly termed as aglA.; See PMID 1320186
An06g00190	Remark: The late-infantile form of neuronal ceroid lipofuscinosis (LINCL) is a progressive and ultimately fatal neurodegenerative disease of childhood. The defective gene in this hereditary disorder, CLN2, encodes a recently identified lysosomal pepstatin-insensitive acid protease.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; See PMID 10330339; See PMID 10428067
An06g00200	Similarity: Regionally restricted similarity to an alpha-amylase and a cellulase gene.
An06g00210	Remark: sequence 379 is one of the corynebacterium glutamicum genes encoding proteins involved in homeostasis RT and adaptation.; Title: similarity to sequence 379 from patent WO0100842-A - Corynebacterium glutamicum
An06g00230	Catalytic activity: S-Adenosyl-L-methionine + 3-Demethylubiquinone-9 = S-Adenosyl-L-homocysteine + Ubiquinone-9.; Similarity: ORF is similar to several methyl transferases.; Title: similarity to 3-demethylubiquinone-9 3-O-methyltransferase ubiG - Escherichia coli; See PMID 8703953
An06g00240	Similarity: shows similarity only against N-terminal half of An02g01340 .; Title: similarity to hypothetical protein encoded by An02g01340 - Aspergillus niger
An06g00250	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An06g00260	Function: S. cerevisiae HXT5 is one of 7 metabolically relevant hexose transporters.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3229, 2191 and 3169.; Similarity: S. cerevisiae HXT5 is a member of the superfamily of monosaccharide facilitators.; Title: strong similarity to hexose transporter Hxt5 - Saccharomyces cerevisiae; plasma membrane; See PMID 7651133
An06g00270	Title: similarity to hypothetical protein encoded by An07g06270 - Aspergillus niger
An06g00280	Title: strong similarity to hypothetical protein YBR096w - Saccharomyces cerevisiae
An06g00290	Function: A. niger lacA is a thermostable beta-galactosidase, involved in lactose-utilisation.; Localization: A. niger lacA is a secreted protein.; Title: strong similarity to beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 1368193
An06g00300	Function: N. tabacum TABPPT8 is a phosphoenolpyruvate/phosphate antiporter.; Function: N. tabacum TABPPT8 mediates plastidic transport of inorganic phosphate in exchange with C3 compounds phosphorylated at C-atom 2, particularly phosphoenolpyruvate.; Localization: N. tabacum TABPPT8 localises to plastides in green and non-green tissue.; Title: similarity to phosphate/phosphoenolpyruvate translocator TABPPT8 - Nicotiana tabacum; See PMID 9090886
An06g00310	Function: P. janthinellum carboxypeptidase D shows broad specificity with optimum pH 4. 5-6. 0, preferential releases a C-terminal arginine or lysine residue and is inhibited by the action of diisopropyl fluorophosphate or thiol-blocking reagents.; Remark: in P. janthinellum carboxypeptidase D the hydrolysis of peptide substrates is apparently dependent on three ionizable group with different pKa values, the substrate preference of the enzyme is consequently pH dependent. .; Similarity: P. janthinellum carboxypeptidase D belongs to peptidase family S10.; Title: similarity to carboxypeptidase D -Penicillium janthinellum; See PMID 8224168; See PMID 3256309
An06g00320	Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs Nig056 and an_0358, which also cover the 5' and 3'UTRs.; Title: strong similarity to EST an_0358 -Aspergillus niger
An06g00330	Remark: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: A. nidulans facB belongs to the Zn[2]-Cys[6] fungal-type binuclear cluster proteins.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 9524126; See PMID 10483720
An06g00340	Catalytic activity: carboxylesterases convert a carboxylic ester + H(2)O to an alcohol + a carboxylic anion.; Function: Bacillus estA1 showed clear preference for esters of short-chain fatty acids and maximum activity was found at 45 degrees C and pH 7. 5.; Function: carboxylesterases play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs.; Title: similarity to type B carboxylesterase estA1 -Bacillus sp.; See PMID 9597156; See PMID 11178722
An06g00350	Catalytic activity: triacylglycerol lipases convert triacylglycerol + H(2)O convert diacylglycerol + a fatty acid anion.; Function: C. rugosa expresses multiple extracellular lipases of which LIP1 is the most highly and constitutively expressed.; Title: similarity to extracellular triacylglycerol lipase Lip1 - Candida rugosa; extracellular/secretion proteins; See PMID 10473391
An06g00360	Function: mutations in S. cerevisiae dfg5 block filamentous growth.; Remark: the systematic name for S. cerevisiae DFG5 is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077
An06g00370	Catalytic activity: Glutathione transferases convert RX + glutathione to HX + R-S-glutathione.; Function: Rhodococcus sp. isoI is a glutathione S-transferase with activity towards 1,2-epoxy-2-methyl-3-butene.; Function: isoI is involved in isoprene (2-methyl-1,3-butadiene) utilization in Rhodococcus sp. strain AD45.; Remark: the Exon-Intron structure of the predicted A. niger protein is not completely in accordance with the A. niger EST an_1163, which may be due to errors in the genomic sequence or artefacts in the EST.; Title: similarity to glutathione S-transferase isoI - Rhodococcus sp.; See PMID 10715003
An06g00380	Catalytic activity: Hexokinases convert ATP + D-hexose (D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors) to ADP + D-hexose 6-phosphate.; Complex: A. niger hxk is a homodimer.; Function: A. niger hxk phosphorylates D-Glucose, the glucose analogue 2-deoxy-D-glucose, D-fructose, D-mannose and D-glucosamine but not D-galactose, L-sorbose, methyl alpha-D-glucoside and the pentoses L-arabinose and D-xylose.; Repression: A. niger hxk is strongly inhibited by physiological concentrations of trehalose 6-phosphate.; Title: strong similarity to hexokinase hxk -Aspergillus niger; See PMID 9851713
An06g00390	Catalytic activity: Oxoglutarate dehydrogenases convert 2-oxoglutarat e+ lipoamide to S-succinyldihydrolipoamide + CO(2).; Complex: S. cerevisiae KGD1 is a component of the multienzyme 2-oxoglutarate dehydrogenase complex.; Remark: an alternative name for S. cerevisiae KGD1 is OGD1.; Repression: in S. cerevisiae transcription of KGD1 is catabolite repressed.; Similarity: similarity is from the predicted A. niger protein only to half of the central and the C-terminal regions of several oxoglutarate dehydrogenases,which are 600 aa longer.; Title: similarity to oxoglutarate dehydrogenase Kgd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2503710
An06g00410	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An06g00420	Function: S. purpuratus kinesin light chain is a motor molecule required for transport with family specific directionallity to plus or minus ends of microtubuli.; Remark: possible sequencing errors occured at position 45518 and 45818 leading to stop codons, 2 bases have been changed to 'N'.; Similarity: similarity is from the predicted A. niger protein to the N-terminal region of S. purpuratus kinesin light chain, which is 400 aa longer.; Title: similarity to kinesin light chain KLC -Strongylocentrotus purpuratus [putative sequencing error]; cytoskeleton; putative sequencing error; See PMID 8496962; See PMID 10722881; See PMID 10722883
An06g00430	Catalytic activity: Chalcone synthases convert 3 malonyl-CoA + 4-coumaroyl-CoA to 4 CoA + naringenin-chalcone + 3 CO(2).; Function: G. hybrida GCHS2 is an unusual chalcone synthase, catalysing a non-SS variant of the CHS reaction,with both different substrate specificity (to benzoyl-CoA) and a modified catalytic profile.; Function: rrpA, a Streptomyces griseus homolog of plant Chalcone synthases, was shown to catalyse polyketide synthesis by four successive extensions of malonyl-CoA.; Title: strong similarity to chalcone synthase Gchs2 - Gerbera hybrida; See PMID 7787187; See PMID 8799149; See PMID 10476972
An06g00460	Catalytic activity: cholinesterases convert an acylcholine + H(2)O to choline + a carboxylic acid anion.; Function: B. floridae ChE1 hydrolyzes both acetylthiocholine and butyrylthiocholine.; Localization: the sequence of B. floridae ChE1 shows characteristics of H-type catalytic subunits, which are inserted in the membrane via an ethanolamine-glycan-phosphatidylinositol anchor, and by biochemichal evidence the vast majority of ChE1 is present as ethanolamine-glycan-phosphatidylinositol-anchored form in vivo.; Remark: B. floridae ChE1 contains a novel acyl-binding site.; Title: similarity to cholinesterase 1 ChE1 -Branchiostoma floridae; See PMID 9874207
An06g00470	Remark: expression of the S. solfataricus AAC38214. 1 ORF was shown by Northern blot.; Title: weak similarity to hypothetical serine-rich protein SPCC553.10 - Schizosaccharomyces pombe; See PMID 9495770
An06g00480	Function: in addition to reducing the dialdehydic form of aflatoxin B1-8,9-dihydrodiol, human AFAR shows high affinity for the gamma-aminobutyric acid metabolite succinic semialdehyde (SSA).; Similarity: human AFAR is a AKR7-familiy member of the aldo-keto reductase superfamily.; Title: weak similarity to aflatoxin aldehyde reductase AFAR - Homo sapiens; See PMID 9576847
An06g00490	Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: similarity is from the predicted A. niger protein to the central region of M. grisea Pth11,which is 300 aa longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An06g00500	Remark: blastp with the predicted A. niger protein only retrieves random hits to glutamate, glutamine and lysine rich proteins.
An06g00510	Catalytic activity: glucan endo-1,3-alpha-glucosidase catalyzes the conversion of Endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.; Function: P. purporogenum mutA is a mutanase (glucan endo-1,3-alpha-glucosidase) involved in polysaccharid catabolism.; Title: similarity to alpha-1,3-glucanase mutA -Penicillium purporogenum; See PMID 10636904
An06g00530	Similarity: the N-terminal region of the predicted A. niger protein shows similarity to several splicosomal and ribosomal proteins.
An06g00540	Induction: A. nidulans stcQ is induced only under ST-producing conditions.; Remark: at position 27607 a possible sequencing error occured and 1 base was removed.; Title: similarity to sterigmatocystin biosynthetic gene stcQ - Aspergillus nidulans [putative frameshift]; putative frameshift
An06g00550	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An06g00560	Induction: S. cerevisiae HXT genes are induced by glucose.; Remark: S. cerevisiae has 20 genes encoding known or likely glucose transporters (HXT 1-20), each of which is known or likely to have a different affinity for glucose.; Repression: S. cerevisiae HXT genes are repressed in the absence of glucose due to a mechanism that requires Rgt1p and Ssn6p.; Title: strong similarity to hexose transporter Hxt13 - Saccharomyces cerevisiae; plasma membrane; See PMID 7862149; See PMID 10477308
An06g00570	Similarity: the N-terminal of the predicted A. niger protein shows similarity to several kinases and contains a kinase SCOP motif, however overal the similarity is not significant to any protein.
An06g00580	Title: strong similarity to hypothetical protein EAA61328.1 - Aspergillus nidulans
An06g00590	Similarity: the predicted A. niger protein shows strong similarity to to EST an_2107 from Aspergillus niger.; Title: strong similarity to hypothetical protein yrkC - Bacillus subtilis
An06g00600	Function: A. parasiticus adhA catalyses the conversion of 5'-hydroxyaverantin (HAVN) to 5'-ketoaverantin, the open-chain form of averufin (AVF) in the synthesis of aflatoxin.; Pathway: adhA of A. parasiticus catalyzes a step in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914
An06g00610	Function: S. cerevisiae cells depleted of CKA1 and CKA1 increase substantially in size prior to growth arrest,and a significant fraction of the arrested cells exhibit a pseudomycelial morphology.; Function: S. cerevisiae cells in which the CKA2 gene alone is disrupted show no detectable phenotype, but haploid cells carrying disruptions in both the CKA1 and CKA2 genes are inviable.; Remark: Casein kinase II of S. cerevisiae contains two distinct catalytic subunits, alpha and alpha', which are encoded by the CKA1 and CKA2 genes, respectively; Title: weak similarity to casein kinase II Cka2 -Saccharomyces cerevisiae; See PMID 2196445
An06g00620	Function: S. cerevisiae Mal11p is a high-affinity,general alpha-glucoside/proton symporter transporting maltose, turanose, isomaltose, alpha-methylglucoside,maltotriose, palatinose, trehalose and melezitose.; Induction: expression of S. cerevisiae Mal11p is maltose inducible and induction is mediated by the Mal-activator.; Remark: an alternative name for S. cerevisiae MAL11 is AGT1.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329
An06g00630	Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 9501474; See PMID 9683653
An06g00640	Function: S. cerevisiae PUT3 binds to DNA sequences in the promoters of the proline utilization genes and is required for the basal and induced expression of the enzymes of this pathway.; Similarity: S. cerevisiae PUT3 is 300 aa longer than the predicted A. niger protein.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; nucleus; See PMID 2017167
An06g00650	Function: R. norvegicus 5-Oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 8943290
An06g00660	Catalytic activity: ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate.; Function: OPLA catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: N-terminally truncated due to contig border.; Remark: The rat kidney enzyme OPLA is composed of two strongly interacting, apparently identical subunits (Mr = 142,000).; Remark: possible sequencing error at position 22722,1 bp too little.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 8943290
An06g00670	Title: strong similarity to hypothetical protein encoded by An02g00370 - Aspergillus niger
An06g00680	Title: similarity to hypothetical protein encoded by An05g01220 - Aspergillus niger
An06g00690	Similarity: shows strong similarity against C-terminal part of An05g00630.; Title: weak similarity to hypothetical protein B7N4.20 - Neurospora crassa
An06g00700	Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa
An06g00710	Title: similarity to beta-lactamase from patent FR2792651-A1 - Pyrococcus abyssi
An06g00720	Catalytic activity: the chloroperoxidase converts 2 RH and 2 chloride and H(2)O(2) to 2 RCl and 2 H(2)O.; Function: chloroperoxidase CPO of C. fumago catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione); the enzyme also has potent catalase activity and in the absence of halide ion, acts as a peroxidase similar to plant peroxidases.; Title: similarity to chloroperoxidase CPO -Caldariomyces fumago
An06g00730	Remark: N-terminally truncated due to contig border.; Title: similarity to hypothetical protein encoded by An14g07040 - Aspergillus niger [truncated ORF]
An06g00750	Function: NADP-dependent mannitol dehydrogenase (MtDH) is the enzyme responsible for mannitol biosynthesis in Agaricus bisporus.; Remark: mannitol, a six-carbon sugar alcohol, is the main storage carbon in Agaricus bisporus.; Title: strong similarity to NADP-dependent mannitol dehydrogenase MtDH - Agaricus bisporus; See PMID 9835550
An06g00760	Function: the avnA gene encodes a fungal cytochrome P-450 monooxygenase which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: AvnA has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431
An06g00770	Function: TOXA of Cochliobolus carbonum encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 10656588
An06g00780	Remark: only partial similarity to the aminopeptidase.; Remark: see also patent database match against human aminopeptidase.; Title: weak similarity to aminopeptidase N - Felis catus
An06g00790	Remark: questionable ORF due to the gene structure.; Title: questionable ORF
An06g00800	Remark: transposase is located within the insertion sequence ISTfe1 in Thiobacillus ferrooxidans.; Title: weak similarity to transposase - Thiobacillus ferrooxidans
An06g00810	Function: mutA of P. purporogenum hydrolysis 1,3-alpha-D-glucosidic links.; Remark: P purporogenum mutA is also named alpha1,3-glucanase.; Remark: putative frameshift at position 4879, 2 bp too much.; Title: strong similarity to mutanase mutA -Penicillium purporogenum [putative frameshift]; putative frameshift; See PMID 10636904
An06g00820	Title: similarity to eukaryotic translation initiation factor eIF2B subunit 3 - Homo sapiens; See PMID 10900014; See PMID 9438375
An06g00830	Title: weak similarity to hypothetical transcription regulatory protein SPBC530.08 - Schizosaccharomyces pombe
An06g00840	Title: similarity to hypothetical protein SPBC2A9.02 - Schizosaccharomyces pombe
An06g00850	Catalytic activity: glycerol 3-phosphate + H(2)O = glycerol + phosphate.; Remark: alternate names in yeast = RHR2, YIL053W.; Title: strong similarity to (DL)-glycerol-3-phosphatase 1 Gpp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8662716; See PMID 9038161
An06g00860	Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa
An06g00880	Remark: questionable ORF due to the gene structure.; Title: questionable ORF
An06g00890	Similarity: the ORF shows similarity to several oxidoreductases with unspecified function.; Title: weak similarity to gibberellin 20-oxidase -Cucurbita maxima; See PMID 9435996
An06g00930	Title: weak similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An06g00940	Title: weak similarity to hypothetical nucleobinding precursor NUCB1 - Homo sapiens
An06g00950	Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa
An06g00960	Title: similarity to hypothetical ankyrin At2g03430 - Arabidopsis thaliana
An06g00970	Similarity: weak similarity at the carboxyterminus to unknown protein of E. nidulans.; Title: weak similarity to hypothetical protein CAD28442.1 - Aspergillus fumigatus
An06g00990	Function: enzyme of S. cerevisiae catalyzes the reduction of fumarate to succinate.; Remark: contains binding domain for FAD that is usually noncovalently bound.; Title: strong similarity to soluble cytoplasmic fumarate reductase YEL047c - Saccharomyces cerevisiae; cytoplasm; See PMID 8946166
An06g01000	Similarity: most blast hits result from repetitive sequences.
An06g01020	Remark: The overexpression of the protein of S. cerevisiae confers resistance to the toxicity of molasses.; Title: similarity to hypothetical molasses resistency protein Rtm1 - Saccharomyces cerevisiae
An06g01030	Remark: similarity spans the C-terminal two-thirds of An01g01370.; Title: similarity to hypothetical protein encoded by An01g01370 - Aspergillus niger
An06g01040	Catalytic activity: protein of S. cerevisiae converts ATP + ubiquitin + protein lysine to AMP + pyrophosphate + protein N-ubiquityllysine.; Function: protein of S. cerevisiae 6 the covalent attachment of ubiquitin to other proteins. Ubc7p is involved in stress related ER degradation. Ubc6p and Ubc7p target unfolded or misfolded lumenal ER proteins for retrograde transport across the ER membrane and subsequent degradation by the proteasome.; Title: strong similarity to ubiquitin conjugation enzyme Ubc7 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8781238
An06g01050	Similarity: shows like ORF60CG similarity to 7-aminocholesterol resistance protein RTA1 of S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC17G6.02c - Schizosaccharomyces pombe
An06g01060	Similarity: weak similarity to probable membrane protein YLR228c of S. cerevisiae; covers carboxyterminus of the S. cerevisiae protein only.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism
An06g01070	Title: similarity to hypothetical protein CG4770 -Drosophila melanogaster
An06g01080	Function: might be involved in transportation of cations like zinc.; Localization: probable membrane protein.; Remark: truncated ORF due to contig border, no start codon.; Similarity: shows strong similiarity to cation/efflux domain members.; Title: similarity to hypothetical membrane protein YDR205w - Saccharomyces cerevisiae [truncated ORF]
An06g01090	Remark: multiple putative sequencing errors in contig; blastx analysis of 3' downstream region reveals similarity to aa 1-413 of An11g07820 covering coordinates 129-1495 of the contig. Only the N-terminal part has been extracted as ORF.; Similarity: An11g07820 shows strong similarity to multidrug resistance protein MRP of M. musculus.; Title: similarity to hypothetical protein encoded by An11g07820 - Aspergillus niger [putative sequencing error]
An06g01100	Catalytic activity: GDP-Man + dolichol-PP-GlcNAc2 -> dolichol-PP-GlcNAc2-Man + GDP.; Function: the mannosyltransferase Alg1 from S. cerevisiae participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation.; Title: strong similarity to mannosyltransferase Alg1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 2182636; See PMID 9675821
An06g01110	Title: weak similarity to hypothetical protein T1G12.10 - Arabidopsis thaliana
An06g01120	Function: N. crassa Mus-8 rescues the DNA repair,mutagenesis, and sporulation defects of S. cerevisiae rad6 mutants.; Function: substrate specific ubiquitination by Ubiquitin-ligase (E3), in conjunction with ubiquitin-conjugating enzyme (E2), specifically targets proteins for proteasomal degradation.; Similarity: N. crassa Mus-8 is an E2-type ubiquitin-conjugating enzyme.; Title: strong similarity to ubiquitin conjugating enzyme mus-8 - Neurospora crassa; See PMID 9990117; See PMID 8753651
An06g01130	Function: kinesins are microtubule associated motors involved in the transport of membrane bound organelles,transport between the endoplasmic reticulum and the Golgi and transport of protein complexes to cellular destinations.; Remark: in the revised IUPAC Enzyme Nomenclature + and - end directed kinesin is designated the EC Number 3. 6. 4. 4 and 3. 6. 4. 5 respectively.; Title: strong similarity to kinesin heavy chain Nkin - Neurospora crassa; cytoskeleton; See PMID 10754574; See PMID 8631782
An06g01140	Function: S. aerocolonigenes ngt was found to introduce a D-glucose moiety into 6-N-methylarcyriaflavin C.; Title: strong similarity to N-glycosyltransferase ngt - Saccarothrix aerocolonigenes; See PMID 10866221
An06g01160	Catalytic activity: human SRPK2 is a serine specific kinase catalysing the reaction, ATP + a protein <=> ADP + a phosphoprotein.; Function: human SRPK2 mediates the interaction and localization of pre-mRNA splicing factors by phosphorylating the SR family of splicing factors.; Localization: FLAG- and GFP-tagged human SRPK2 was visible in the cytoplasm and the nuclei of HeLa cells.; Title: similarity to serine kinase SRPK2 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9472028
An06g01170	Similarity: the predicted A. niger protein shows similarity to several bacterial hypothetical acetyl-CoA synthetases.; Title: similarity to hypothetical long-chain-fatty-acid--CoA ligase SC6F7.21 - Streptomyces coelicolor
An06g01180	Similarity: shows also similarity to N-terminal half of An08g01460.; Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii
An06g01190	Function: S. cerevisiae Frq1 binds to a conserved sequence motif in Pik1, a phosphatidylinositol-4-OH kinase,outside Pik1's catalytic domain and stimulates its activity in vitro.; Function: S. cerevisiae Frq1 is essential for growth of budding yeast.; Function: in S. cerevisiae N-myristoylated Frq1 may also assist in Pik1 localization.; Localization: subcellular fractionation experiments showed that both the N-myristoyl group and Ca(2+)-binding contribute to the ability of Frq1 to associate with membranes.; Remark: the systematic name for S. cerevisiae Frq1 is YDR373w.; Similarity: S. cerevisiae Frq1 belongs to the recoverin/frequenin branch of the EF-hand superfamily.; Title: strong similarity to Ca(2+)-binding protein Frq1 - Saccharomyces cerevisiae; See PMID 10559922; See PMID 11015193
An06g01200	Title: strong similarity to endosomal protein Emp70 - Saccharomyces cerevisiae; endosome; See PMID 9729438; See PMID 8314797
An06g01210	Complex: in S. cerevisiae antibodies directed against Lcp5p specifically immunoprecipitated the yeast U3 snoRNA snR17.; Function: in S. cerevisiae mutations in LCP5 caused defects in pre-ribosomal RNA (pre-rRNA) processing impairing early cleavage steps that lead to the production of mature 18S rRNA.; Localization: in S. cerevisiae indirect immunofluorescence indicated a predominant localization of Lcp5p in the nucleolus.; Remark: the systematic name for S. cerevisiae LCP5 is YER127w.; Title: similarity to rRNA processing protein Lcp5 -Saccharomyces cerevisiae; nucleus; See PMID 9814757
An06g01260	Title: strong similarity to hypothetical protein CAC28835.1 - Neurospora crassa
An06g01270	Catalytic activity: N. crassa uve1 cleaves both cyclobutane pyrimidine dimers and (6-4)photoproducts at the sites immediately 5' to the damaged dipyrimidines in a magnesium-dependent, ATP-independent reaction.; Function: N. crassa uve1 specifically repairs DNA damaged by ultraviolet light.; Remark: N. crassa uve1 confers UV-resistance on various DNA repair-deficient mutants of S. cerevisiae and a human xeroderma pigmentosum cell line.; Title: strong similarity to UV-endonuclease uve1 -Neurospora crassa; nucleus; See PMID 7774597
An06g01290	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An06g01300	Function: AM-toxin synthetase (AMT) is a primary determinant of virulence and specificity in the A. alternata apple pathotype/apple interaction.; Remark: Afternaria afternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin,AM-toxin.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335
An06g01320	Catalytic activity: ATP dependent conversion of ferulic acid to feruloyl-Coenzyme A.; Pathway: Fcs catalyzes a step in the bioconversion of ferulic acid to vanillin.; Title: strong similarity to feruloyl-CoA synthase fcs - Amycolatopsis sp.; See PMID 11152072
An06g01340	Remark: N-terminally truncated due to contig border.; Title: weak similarity to hypothetical possible phosphatase L8329.04 - Leishmania major [truncated ORF]
An06g01350	Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to proline rich proteins.
An06g01360	Function: S. cerevisiae BSD2 down-regulates heavy metal uptake by the Nramp metal transporters Smf1p and Smf2p at the level of protein stability.; Function: in bsd2Delta mutants, Smf1p and Smf2p fail to enter the vacuole where they are normally degraded by vacuolar proteases in a PEP4-dependent manner.; Title: similarity to metal homeostasis protein Bsd2 - Saccharomyces cerevisiae; See PMID 9115231; See PMID 9988727; See PMID 11027260
An06g01370	Catalytic activity: 3-oxoacid CoA-transferases convert Succinyl-CoA + a 3-oxo acid to succinate + a 3-oxo-acyl-CoA.; Complex: human SCOT forms a homodimer.; Function: human SCOT mediates the rate-determining step of ketolysis, the esterification of acetoacetate to CoA for use in energy production.; Title: strong similarity to Succinyl CoA: 3-oxoacid CoA transferase SCOT - Homo sapiens; localisation:mitochondrion; See PMID 8751852
An06g01380	Function: ubiquitin-specific proteases like S. cerevisiae UPB2 cleave ubiquitin fusions to itself or other proteins after the last (Gly76) residue of ubiquitin.; Title: strong similarity to ubiquitin specific protease Ubp2 - Saccharomyces cerevisiae; cytoplasm; See PMID 1429680
An06g01390	Title: strong similarity to 21.3 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1825789; See PMID 10940377
An06g01400	Function: Ask10p of S. cerevisiae is a transcription factor involved in a Skn7p-mediated two-component regulatory system.; Remark: the ORF is N-terminally truncated due to end of contig. .; Similarity: YIL105c of S. cerevisiae is similar to transcriptional activator Ask10p of S. cerevisiae.; Similarity: the N-terminal portion shows similarity to transcription regulator protein Ask10p of S. cerevisiae.; Title: strong similarity to hypothetical protein YIL105c - Saccharomyces cerevisiae [truncated ORF]; See PMID 8904339
An06g01420	Function: TOL in N. crassa mediates growth inhibition and cell death as a result of mating-type-associated heterokaryon incompatibility during vegetative growth.; Similarity: the homology is restricted to the central portion of TOL from N. crassa.; Title: similarity to mating-type-associated vegetative incompatibility factor TOL - Neurospora crassa; See PMID 9927450
An06g01430	Title: strong similarity to hypothetical protein encoded by An14g06130 - Aspergillus niger
An06g01440	Function: TOM34 (HRB1) of S. cerevisiae is a hnRNP-like protein of unknown function possibly involved in RNA processing and export.; Localization: TOM34 (HRB1) of S. cerevisiae is capable of shuttling between the nucleus and the cytoplasm.; Remark: TOM34 of S. cerevisiae is also named HRB1.; Remark: a splice site was detected upstream of the START codon.; Similarity: contains three RNA-binding motives.; Similarity: shows much better homology to S. pombe hrb1 homolog, but the latter is so far not experimentally confirmed.; Title: similarity to heterogeneous nuclear ribonucleoprotein (hnRNP) Tom34 - Saccharomyces cerevisiae; See PMID 9499403
An06g01450	Title: weak similarity to U1 snRNP 70K protein - Mus musculus
An06g01460	Title: similarity to hypothetical protein SPAC19G12.11 - Schizosaccharomyces pombe
An06g01470	Similarity: the ORF is much shorter than igA of N. meningitidis (459 compared to 1773 amino acids) and the homology between the two proteins is restricted to a stretch of about 200 amino acids.; Title: weak similarity to IgA-specific metalloendopeptidase igA - Neisseria meningitidis
An06g01480	Remark: the homology between the ORF and the hypothetical yeast protein is restricted to about 400 N-terminal amino acids.; Title: similarity to hypothetical protein YDL156w -Saccharomyces cerevisiae
An06g01490	Function: CLA2 of S. cerevisiae stimulates the GTPase activity of BUD1/RSR1 and thus participates in the regulation of the BUD site selection (axial budding).; Phenotype: chromosomal deletion of CLA2 of S. cerevisiae causes a random budding pattern but no obvious growth defect. Overexpression of BUD2 also causes a random budding pattern.; Remark: CLA2 of S. cerevisiae is also called BUD2,ERC25, or YKL092C.; Remark: CLA2 of S. cerevisiae is similar to other ras GTPase-activating proteins (GAPs).; Similarity: the ORF shows local strong similarity to CLA2 of S. cerevisiae: the two proteins have about the same length, however, only about 400 central amino acids are included in the alignment. The aligned stretch includes the C2-domain and RAS-GAP of CLA2.; Title: strong similarity to inhibitory regulator protein Cla2 - Saccharomyces cerevisiae; See PMID 8262070; See PMID 8371782
An06g01500	Function: Apg9p/Cvt7p of S. cerevisiae is an integral membrane protein required for transport vesicle formation in the cvt and autophagy pathways.; Title: similarity to integral membrane protein required for Cvt and autophagy transport Apg9 -Saccharomyces cerevisiae; See PMID 10662773
An06g01510	Function: in vivo expression of the cDNA of S. frugiperda using a recombinant baculovirus produced a protein that released [3H]mannose from [3H]Man9GlcNAc.; Function: these results indicate that Sf9 cells encode and express an alpha 1,2-mannosidase with properties similar to those of other eukaryotic processing alpha 1,2-mannosidases.; Function: this activity required calcium, but not magnesium, and was inhibited by 1-deoxymannojirimycin.; Title: strong similarity to class I alpha-mannosidase AAB62720.1 - Spodoptera frugiperda; See PMID 9147053
An06g01520	Similarity: similarity restricted to aminoterminal part of the putative protein.; Title: similarity to hypothetical protein SPBC24C6.10c - Schizosaccharomyces pombe
An06g01530	Function: S. cerevisiae protein is responsible for successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: it can link beta-1,3-glucan chains with beta-1,6-linkage.; Function: it may play a role in cell expansion during growth, in mating, and in spore release.; Similarity: stronger similarity to several putative cell wall proteins of S. cerevisiae.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; cell wall; See PMID 9090054; See PMID 9748433
An06g01540	Function: S. cerevisiae enzyme converts palmitoyl-CoA + L-serine to CoA + 3-dehydro-D-sphinganine + CO2.; Pathway: first step in the biosynthesis of the long-chain base component of sphingolipids.; Title: strong similarity to serine C-palmitoyltransferase chain Lcb1 - Saccharomyces cerevisiae
An06g01550	Function: 1,3-beta-D-glucan is a fungal cell wall polymer synthesized by the multi-subunit enzyme 1,3-beta-D-glucan synthase.; Function: glycosyl transferase is a membrane protein for fungal cell wall synthesis.; Title: strong similarity to glucan synthase FKS -Paracoccidioides brasiliensis; plasma membrane
An06g01580	Remark: Only the the c-terminal half of the ORF encoded protein shows a strong similarity to the S. pombe hypothetical protein SPBC19G7. 04.; Title: similarity to hypothetical protein SPBC19G7.04 - Schizosaccharomyces pombe
An06g01590	Remark: S. cerevisiae Mog1p is involved in nuclear-protein import.; Remark: the S. cerevisiae Mog1p, directly interacts with GTP-Gsp1p, the S. cerevisiae ran homologue.; Title: similarity to protein Mog1 - Saccharomyces cerevisiae; See PMID 9860978
An06g01600	Title: similarity to hypothetical protein T22D1.2 -Caenorhabditis elegans
An06g01610	Similarity: the ORF encoded protein shows the strongest similarity to the Awh11 heat shock protein from Emericella nidulans, functional studies about it are not published yet.; Title: strong similarity to heat shock protein hsp9p - Schizosaccharomyces pombe; See PMID 8679693
An06g01620	Remark: the ApsB protein from Emericella nidulans seams to play a role in the regulation nuclear migration.; Remark: the ORF encoded protein (241aa) shows similarity to ApsB (1051aa) from Emericella nidulans with an E. val of 2e-05.; Title: similarity to protein apsB - Aspergillus nidulans; See PMID 10094631
An06g01630	Title: strong similarity to hypothetical protein KIAA1134 - Homo sapiens
An06g01640	Remark: S. cerevisiae NGG1 = ADA3.; Remark: interaction between (S. cer) Nif1p and (S. cer.) Ngg1p/Ada3p was found in a large-scale yeast two-hybrid screen.; Title: strong similarity to Ngg1p-interacting factor Nif3 - Saccharomyces cerevisiae; See PMID 10688190
An06g01650	Title: strong similarity to hypothetical protein encoded by AAM68636.1 - Drosophila melanogaster
An06g01660	Remark: the Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis.; Title: strong similarity to thioredoxin peroxidase PMP20 - Mus musculus; See PMID 1067930
An06g01690	Function: the S. cerevsiae Skn7 regulator may be involved in response to oxidative stress.; Remark: the ORF encoded protein belongs to the helix-turn-helix transcription factor family.; Title: similarity to transcription regulator Skn7 -Saccharomyces cerevisiae; See PMID 8226633; See PMID 8598053
An06g01710	Complex: the S. cerevisiae GCD6 gene product is part of a complex of five different subunits alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to translation initiation factor eIF2b epsilon Gcd6 - Saccharomyces cerevisiae; See PMID 8441423; See PMID 9032257; See PMID 926828; See PMID 9472020
An06g01720	Similarity: the ORF encoded shows strong similarity to the D. melanogaster ariadne protein and its homologues.; Title: strong similarity to Ariadne protein ari -Drosophila melanogaster
An06g01730	Function: MRS3 (S. cer.) is essential for the splicing of group II introns and is also involved in processes of mitochondrial biogenesis other than RNA splicing.; Function: MRS3 (S. cer.) may act as a carrier,exerting its suppressor activity via modulation of solute concentrations in the mitochondria.; Function: the MRS3 gene product of S. cerevisiae probably is involved in splicing of aI1 intron for COB gene.; Similarity: the ORF encoded protein is a member of the mitochondrial carrier family.; Title: strong similarity to mtRNA splice defect-suppressing mitochondrial carrier Mrs3 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2448588; See PMID 1703236
An06g01740	Similarity: the ORF encoded protein shows also strong similarity to the to regulatory subunits of 26s proteasome from S. cerevisiae Yta6p and its S. pombe homologue with the gene ID: SPDB:SPBC947. 01.; Title: strong similarity to SIN1-associated protein Sap1 - Saccharomyces cerevisiae; See PMID 8654588; See PMID 9695811
An06g01750	Complex: the human epsin 2a binds to clathrin heavy chain, AP-2, Eps15, and intersectin.; Title: strong similarity to clathrin binding protein epsin-2a - Homo sapiens; See PMID 10567358
An06g01760	Catalytic activity: chorismate + L-glutamine <=> anthranilate + pyruvate+L-glutamate.; Complex: the S. cerevisiae homolog anthranilate synthase:indole-3-glycerol phosphate synthase is a multifunctional hetero-oligomeric enzyme encoded by genes TRP2 and TRP3.; Function: the S. cerevisiae homolog TRP2 encodes the anthranilate synthase subunit I.; Pathway: tryptophan biosynthesis.; Title: strong similarity to anthranilate synthase component I Trp2 - Saccharomyces cerevisiae; See PMID 6323449; See PMID 8432699
An06g01770	Similarity: the ORF encoded protein shows a weak similarity to paramyosin from C. elegans E. val. : 0. 23.; Title: weak similarity to paramyosin unc-15 -Caenorhabditis elegans; See PMID 2754728; See PMID 2754733; See PMID 8408214
An06g01780	Complex: the human TBL1 protein is part of a core SMRT corepressor complex containing the histondeacetylase HDAC3.; Title: strong similarity to (beta)-transducin like protein TBL1 - Homo sapiens; See PMID 10330347; See PMID 10809664; See PMID 10944117
An06g01800	Title: questionable ORF
An06g01810	Remark: the human gene for the PL16 protein was found as a novel human cDNA that is homozygously deleted in small cell lung cancerand located to 3p21. 3.; Title: strong similarity to protein PL6 - Homo sapiens
An06g01820	Remark: the ORF encoded protein shows also weak similarity to the 'real' ribosomal protein MRP49 from the S. cerevisiae mitochondria with an E. -val. of 1e-04.; Title: similarity to hypothetical ribosomal protein B13I18.70 - Neurospora crassa
An06g01830	Catalytic activity: ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu).; Title: strong similarity to cytosolic leucine--tRNA ligase - Neurospora crassa; cytoplasm; See PMID 2532300; See PMID 2842224
An06g01840	Catalytic activity: 1-aminocyclopropane-1-carboxylate + H(2)O <=> 2-oxobutanoate + NH(3).; Remark: in Penicillium citrinum two enzyms could be found which are involved in the biosythesis of ethylene,known as plant hormone of higher plants: ACC synthase [EC 4. 4. 1. 14] and ACC deaminase [EC 4. 1. 99. 4]. ACC=1-Aminocyclopropane-1-carboxylic acid= Ethylen precursor.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate deaminase,acs -Penicillium citrinum; See PMID 10227140; See PMID 10737185
An06g01850	Title: strong similarity to hypothetical protein B13I18.80 - Neurospora crassa
An06g01860	Title: strong similarity to hypothetical protein SPAC31G5.18c - Schizosaccharomyces pombe
An06g01870	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S10 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530
An06g01880	Function: HyuC from Pseudomonas sp. (strain NS671) converts N-carbamyl-L-amino acids to L-amino acids.; Pathway: HyuC from Pseudomonas sp. (strain NS671) is involved in conversion of 5-substituted hydantoins to corresponding L-amino acids.; Similarity: HyuC from Pseudomonas sp. (strain NS671) belongs to peptidase family M40, also known as the Ama/HipO/HyuC family of hydrolases.; Title: strong similarity to N-carbamyl-L-amino acid amidohydrolase HyuC - Pseudomonas sp.; See PMID 1732229
An06g01890	Remark: Hnt1 from S. cerevisiae interacts with the cyclin dependent kinase Kin28.; Similarity: the encoded protein belongs to the HIT superfamily. HINT subfamily.; Title: similarity to histidine triad protein Hnt1 -Saccharomyces cerevisiae; See PMID 10958787; See PMID 11805111
An06g01900	Remark: a splice site was detected upstream of the START codon.; Remark: the expression of Ssh2 from Glycine max in S. cerevisiae bypasses the requirement for an essential phosphatidylinositoltransfer protein in Golgi secretory function.; Similarity: the ORF coding protein showes the strongest similarity the S. pombe hypothetical protein SPAC3H8. 02 and to the S. cerevisie hypothetical protein YLR380w which are both similar to proteins of the Sec14 family.; Title: similarity to polyphosphoinositide binding protein Ssh2p - Glycine max; See PMID 9670016
An06g01910	Remark: A GFP-Dam1p fusion protein expressed in S. cerevisiae revealed a Dam1p association with the intranuclear spindle microtubules and the spindle pole bodies in vivo.; Title: similarity to microtubule-associated protein Dam1 - Saccharomyces cerevisiae; See PMID 9817759
An06g01920	Catalytic activity: Ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Remark: USP3 from Homo sapiens is a deubiquitinating enzyme.; Title: strong similarity to ubiquitin specific protease 3 USP3 - Homo sapiens; See PMID 10480896
An06g01930	Similarity: the ORF is longer than S29 of S. cerevisiae (94 compared to 56 amino acids).; Similarity: the ORF sequence is nearly idenical to EMBLEST:AN743 from Aspergillus niger which shows strong similarity to a s29 similar mRNA.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S29 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530
An06g01950	Title: similarity to hypothetical protein SPBC3B8.06 - Schizosaccharomyces pombe
An06g01960	Catalytic activity: a nitrile + H(2)O <=> a carboxylate + NH(3).; Function: the A. thaliana homolog NIT2 encodes a nitrilase that converts indole-3-acetonitrile to the plant hormone indole-3-acetic acid.; Title: strong similarity to nitrilase NIT2 -Arabidopsis thaliana; See PMID 8016109; See PMID 8022831; See PMID 1555601
An06g01970	Remark: ORF encoded protein belongs to the fungal binuclear zinc cluster family.; Remark: S. cerevisiae PPR1 gene product is a pyrimidin pathway regulating transcription factor.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 9858611
An06g01980	Function: tetrahydroxynaphthalene reductase of Pyricularia grisea is involved in the melanin biosynthesis; Remark: Magnaporthe grisea (=Pyricularia grisea) mutants lacking activities for both trihydroxynaphthalene and tetrahydroxynaphthalene reductases do not produce scytalone, indicating that there are no other metabolic routes to scytalone.; Remark: tetrahydroxynaphthalene reductase of Pyricularia grisea: protein_id AAG29497. 1.; Title: strong similarity to tetrahydroxynaphthalene reductase - Pyricularia grisea; See PMID 10956664
An06g01990	Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An06g02000	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein]+NADP(+)<=>3-oxoacyl-[acyl-carrier protein]+NADPH.; Complex: the Clkr27 gene product from Cuphea lanceolata is integral part of the fatty acid synthase type II.; Pathway: the Clkr27 gene product from Cuphea lanceolata is involved in the fatty acid biosynthesis.; Remark: Only the c-terminal part of the ORF encoded protein (~aa280-aa544) shows significant similarity to the Clkr27 gene product from Cuphea lanceolata. The n-terminal part (aa1-aa206) is significant similar to the probable phosphoglycolate phosphatase BH3587 from Bacillus halodurans. The conection of both ORFs could be caused by a putative sequencing error.; Title: similarity to 3-oxoacyl-(acyl-carrier-protein) reductase Clkr27 - Cuphea lanceolata [putative sequencing error]; See PMID 1376402
An06g02010	Catalytic activity: RX+glutathione<=>HX+R-S-glutathione.; Remark: glutathione s-transferases are a group of enzymes of broad specificity. R may be an aliphatic,aromatic or heterocyclic group. X may be a sulfate, nitrite or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione; the reduction of polyol nitrate by glutathione to polyol and nitrite; certain isomerization reactions and disulfide interchange.; Remark: the URE2 gene product of S. cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.; Similarity: the ORF encoded protein shows strong similarities to many glutathione transferase homologs.; Title: strong similarity to glutathione transferase homolog Ure2 - Saccharomyces cerevisiae; See PMID 1990286; See PMID 8896273
An06g02020	Remark: The expression of the C. albicans FLU1 gene in the S. cerevisiae strain YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide among the different drugs tested.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353
An06g02030	Induction: Mst-1 upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An06g02040	Catalytic activity: enzyme class is involved in hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Remark: the enzyme class shows a wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Title: strong similarity to beta-glucosidase cbg1 -Agrobacterium tumefaciens; See PMID 1537792
An06g02050	Remark: ORF encodes a probable transcriptional regulator of the fungal binuclear zinc cluster type.; Title: strong similarity to hypothetical protein CAD37157.1 - Aspergillus fumigatus
An06g02060	Catalytic activity: successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Title: similarity to exo-1,3-beta-glucanase/1,3-beta-D-glucan glucanohydrolase EXG1 - Yarrowia lipolytica; extracellular/secretion proteins; See PMID 10572260
An06g02070	Function: pectinolytic enzyme RhgA from Aspergillus aculeatus has a positive effect in the apple hot-mash liquefaction process. It hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins. Optimal pH is 3. 5, enzymatic activity becomes unstable above pH 6. 0; optimal temperature is around 30-50 degrees celsius.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus aculeatus; extracellular/secretion proteins; See PMID 7576553; See PMID 7961884; See PMID 8720076; See PMID 9115442
An06g02080	Remark: a putative sequencing error leads to an premature STOP codon.; Remark: the LovC protein is responsible for modulation of polyketide synthase activity in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus [putative sequencing error]; putative sequencing error; See PMID 10334994
An06g02090	Catalytic activity: Trans-trans-farnesyl diphosphate+isopentenyl diphosphate<=>diphosphate+geranylgeranyl diphosphate; Similarity: the ORF coded protein shows strongest similarity to CarG (geranylgeranyl pyrophosphate synthase) of Mucor circinelloides, which funtional evidence is shown,but still unpublished.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Gibberella fujikuroi; See PMID 9230902
An06g02100	Title: weak similarity to hypothetical protein encoded by An03g02050 - Aspergillus niger
An06g02110	Remark: closest manual Blastp hit nompC D. melanogaster shows an E. val of 5e-21.; Remark: nompC from Drosophila melanogaster encodes a new ion channel that is essential for mechanosensory transduction.; Title: similarity to protein nompC - Drosophila melanogaster; See PMID 10744543
An06g02120	Remark: Tyk2 from mouse belongs to Jak (Janus) family and contains Jak homology.; Title: weak similarity to Tyk2 non-receptor tyrosine - Mus musculus; See PMID 10374907
An06g02140	Title: similarity to hypothetical protein encoded by An01g07970 - Aspergillus niger
An06g02150	Similarity: N-terminal third shows similarity to C-terminal two-thirds of An01g11330.; Title: similarity to hypothetical protein CAD70322.1 - Neurospora crassa
An06g02160	Title: strong similarity to hypothetical protein CC0505 - Caulobacter crescentus
An06g02170	Remark: Picea glauca=white spruce.; Remark: the EMB34 transcript during somatic embryo accumulates development of Picea glauca.; Title: similarity to embryonic abundant protein EMB34 - Picea glauca; See PMID 10350098
An06g02180	Title: weak similarity to Traf2 and NCK interacting kinase (splice variant 8) - Homo sapiens; See PMID 10521462
An06g02190	Title: questionable ORF
An06g02200	Title: weak similarity to hypothetical multicopper oxidase precursor encoded by SPAC1F7.08 -Schizosaccharomyces pombe
An06g02210	Remark: the ORF coded protein also show similarity to patent:PATENTPROT:R74205: Human death associated protein DAP-2.; Remark: the mouse inversin gene is involved in the left-right axis pathway in the vertebrate development.; Title: similarity to protein inversin - Homo sapiens; See PMID 9771707
An06g02230	Title: weak similarity to hypothetical protein encoded by An11g05560 - Aspergillus niger
An06g02240	Similarity: blast hits are caused by repetetive sequence motives.; Title: weak similarity to hypothetical protein AAL31335.1 - African swine fever virus
An06g02270	Title: similarity to arabinose transport protein araE - Escherichia coli; plasma membrane; See PMID 2836407; See PMID 6319708
An06g02280	Title: similarity to transesterase lovD -Aspergillus terreus; See PMID 10334994; See PMID 11386351
An06g02290	Similarity: shows weak similarity to integral membrane protein PTH11 of Magnaporthe grisea.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An06g02310	Title: weak similarity to protein 763 from patent FR2807064-A1 - Magnaporthe grisea
An06g02340	Catalytic activity: D-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2.; Title: similarity to D-amino-acid oxidase DAO -Fusarium solani; plasma membrane; See PMID 1982443
An06g02350	Title: strong similarity to hypothetical membrane protein YDL144c - Saccharomyces cerevisiae
An06g02360	Function: NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase from H. sapiens catalyzes the oxidation of many prostaglandins.; Title: similarity to NAD-dependent 15-hydroxyprostaglandin dehydrogenase NAD - Homo sapiens; See PMID 2337593; See PMID 1697582
An06g02370	Title: strong similarity to hypothetical protein SPAC17A3.08 - Schizosaccharomyces pombe
An06g02380	Title: weak similarity to hypothetical protein encoded by An05g00020 - Aspergillus niger
An06g02390	Title: weak similarity to hypothetical protein EAA61302.1 - Aspergillus nidulans
An06g02400	Title: strong similarity to hypothetical protein encoded by SMb20234 - Sinorhizobium meliloti
An06g02420	Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; EC:3.2.1.26; Remark: substrates include sucrose. Also catalyses fructotransferase reactions.; Title: strong similarity to beta-fructofuranosidase precursor suc1 - Aspergillus niger
An06g02430	Title: similarity to hypothetical protein EAA69435.1 - Gibberella zeae
An06g02450	Title: similarity to hypothetical protein CAD70808.1 - Neurospora crassa
An06g02460	Title: similarity to hypothetical beta-hexosamidase A precursor BH0675 - Bacillus halodurans
An06g02470	Similarity: the ORF encoded protein shows also similarities to hypothetical beta-lactamases from other organisms.; Title: strong similarity to protein #695 from patent WO200177335-A2 - Listeria monocytogenes
An06g02480	Title: similarity to putative transcriptional regulator CAF32162.1 - Aspergillus fumigatus
An06g02490	Title: strong similarity to hypothetical protein ybbC - Bacillus subtilis
An06g02500	Title: strong similarity to cellular proliferation protein #230 from patent WO200170955-A2 - Escherichia coli
An06g02510	Title: similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe
An06g02520	Title: weak similarity to hypothetical protein Mx homolog - Equus caballus
An06g02530	Remark: Fusarium oxysporum fatty-acid hydroxylase CYP505 is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3, a fused protein of cytochrome P450 and its reductase.; Title: strong similarity to fatty acid omega-hydroxylase CYP505 - Fusarium oxysporum; See PMID 8830036; See PMID 10995755
An06g02550	Remark: Phytopathogenic fungi such as the fungal plant pathogen Magnaporthe grisea encounter toxic environments during plant invasion as a result of the plant defense response. The pathogenicity factor ABC1 is an ATP-driven efflux pump of the ATP-binding cassette (ABC) superfamily of membrane transporters which is requried for pathogenesis, most likely to protect itself against plant defense mechanisms.; Title: similarity to ABC transporter ABC1 -Magnaporthe grisea; See PMID 9927411
An06g02570	Function: the nit-4 protein from N. crassa is a pathway-specific regulatory transcription factor the of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: the N. crassa nit-4 protein is a DNA-binding transcriptional regulator of the fungal Zn(II)2Cys6 binuclear-zinc-cluster type.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1840634
An06g02580	Function: in C maltosa each of four individual P450alk isoforms is alone sufficient to allow growth on long chain n-alkane.; Function: n-alkane-assimilating yeast contain multiple P450alk genes, which are essential for n-alkane assimilation and are assumed to catalyze terminal hydroxylation of n-alkanes in the assimilation pathway.; Induction: C. tropicalis P450alk2 is alkane-inducible and is induced by tetradecane when C. tropicalis was grown on this carbon source.; Remark: ORF 3'truncated due to end of contig.; Similarity: C. tropicalis P450alk2 is a member of the P450LII/CYP52 gene family.; Title: similarity to cytochrome P450alk2 - Candida tropicalis [truncated ORF]; See PMID 9461581
An06g02590	Similarity: the C-terminal region of the predicted A. niger protein shows similarity to several predicted monooxygenase proteins and contains a flavoprotein COGs domain.; Title: similarity to hypothetical lavin-containing monooxygenase BAC46634 - Bradyrhizobium japonicum
An06g02600	Title: similarity to protein fragment SEQ ID NO:6682 from patent EP1108790-A2 - Corynebacterium glutamicum
An06g02610	Function: V. harveyi fabG is involved in fatty acid biosynthesis.; Remark: possible sequencing error at position 3802 leading to a frameshift.; Similarity: the predicted A. niger protein also shows similarity to Pseudomonas paucimobilis linC, a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase and member of the short-chain alcohol dehydrogenase family.; Title: similarity to 3-ketoacyl-(acyl carrier protein) reductase fabG - Vibrio harveyi [putative frameshift]; putative frameshift; See PMID 7515041; See PMID 8550484
An06g02620	Catalytic activity: N. crassa al-3 converts Trans-trans-farnesyl diphosphate + isopentenyl diphosphate to diphosphate + geranylgeranyl diphosphate.; Function: N. crassa al-3 is a carotenoid biosynthetic enzyme.; Induction: N. crassa al-3 is not expressed in the dark and its transcription is induced by blue light.; Remark: possible sequencing errors at positons 5006 and 4882 leading to frameshifts.; Title: strong similarity to geranylgeranyl pyrophosphate synthase al-3 - Neurospora crassa [putative frameshift]; putative frameshift; See PMID 1826006
An06g02630	Remark: the predicted A. niger protein contains possible sequencing errors at positions 7195, 7261 and 7305 resulting in internal stopcodons and frame shifts.; Remark: the predicted A. niger protein has been classified as putative pseudogene due to its fragmental ORF size and several internal stopcodons and frame shifts.; Similarity: similarity is from the C-terminal half of the predicted A. niger protein to a central region of M. grisea MAGGY Pol, which is 1000 aa longer.; Title: similarity to MAGGY LTR retrotransposon Pol -Magnaporthe grisea [putative pseudogene] [putative frameshift]; putative frameshift
An06g02640	Title: strong similarity to hypothetical protein AAK01512.1 - Pseudomonas aeruginosa
An06g02650	Similarity: the predicted A. niger protein contains PFAM and COGs hydrolase motifs.; Title: strong similarity to hypothetical protein CAD70532.1 - Neurospora crassa
An06g02660	Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus; See PMID 10779399
An06g02670	Function: F. sporotrichioides TRI11 is required for C-15 hydroxylation in trichothecene myotoxin biosynthesis.; Function: disruption of F. sporotrichioides TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: F. sporotrichioides TRI11 defines a cytochrome P-450 gene family, designated CYP65A1; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An06g02680	Similarity: the predicted A. niger protein contains a PFAM hydrolase motif.; Title: similarity to hypothetical protein CAD70532.1 - Neurospora crassa
An06g02690	Title: similarity to protein sequence #10741 from patent WO200175067-A2 - Homo sapiens
An06g02700	Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus; See PMID 10779399
An06g02710	Catalytic activity: cyclohexanol dehydrogenases convert cyclohexanol + NAD(+) to cyclohexanone + NADH.; Function: Acinetobacter chnA is involved in the utilisation of cyclohexanol as a carbon source.; Remark: possible sequencing error at position 21812 leading to a frameshift.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp. [putative frameshift]; putative frameshift; See PMID 10940013
An06g02730	Remark: ORF is 3'truncated due to end of contig.; Similarity: human MTB-Zf contains two widely separated zinc-finger domains located near the N- and C-termini and the similarity is between the predicted A. niger protein fragment and the N-terminal region of MTB-Zf.; Title: similarity to zinc-finger transcription factor MTB-Zf - Homo sapiens [truncated ORF]; nucleus; See PMID 8654390
An08g00010	Catalytic activity: hem2 of C. glabrata converts 2 5-aminolevulinate = porphobilinogen + 2 H(2)O.; Induction: hem2 of C. glabrata requires as zinc as cofactor.; Pathway: hem2 of C. glabrata has delta-aminolevulinate dehydratase activity, which acts in the second steps in the porphyrin and heme biosynthesis.; Phenotype: C. glabrata hem2 mutants are cadmium-sensitive and partially defective in glutathione production and exhibit a complete absence of phytochelatins.; Remark: hem2 of C. glabrata is also called ALADH.; Remark: the ORF contains the sequence of A. niger EST PATENTDNA:F11250 SEQ ID NO:3773.; Title: strong similarity to porphobilinogen synthase hem2 - Candida glabrata
An08g00020	Function: nodL on the Sym plasmid pRL1IJ of R. leguminosarum bv. viciae is a acyltransferase involved in the O-cacetylation of nodulation factors, especially in maintaining the stability of the infection thread.; Induction: nodL of R. leguminosarum bv. viciae is induced in response to flavanone molecules in a nodD-dependent way.; Phenotype: a mutation within nodL of R. leguminosarum strongly reduced nodulation of peas, Lens and Lathyrus but had little effect on nodulation of Vicia species.; Similarity: the ORF shows similarity to several acetyltransferases from different species and with various specificity.; Title: strong similarity to nodulation protein nodL - Rhizobium leguminosarum; See PMID 3132583
An08g00030	Function: pro1 of S. macrospora encodes a C6 zinc finger transcription factor required for fruiting body development.; Similarity: the ORF shows similarity to some zinc-finger containing transcription factors from different species.; Title: similarity to transcription factor pro1 -Sordaria macrospora
An08g00040	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An08g00060	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An08g00070	Function: crm1 is also called exportin 1 and is the receptor for the leucine-rich nuclear export signal.; Function: crm1 of S. pombe is required for maintaining higher order chromosome structures, correct gene expression, and cell growth in the fission yeast.; Title: strong similarity to chromosome region maintenance protein 1 crm1p - Schizosaccharomyces pombe; nucleus; See PMID 10430904
An08g00080	Title: similarity to hypothetical protein encoded by B1D1.100 - Neurospora crassa
An08g00090	Title: weak similarity to hypothetical protein CAD70468.1 - Neurospora crassa
An08g00100	Remark: the hypothetical protein of S. pombe is probably conferring high osmolarity sensitivity.; Title: similarity to hypothetical protein SPAC1805.07c - Schizosaccharomyces pombe
An08g00120	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An08g00140	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An08g00160	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An08g00180	Function: cytochrome p450 proteins act on a wide range of substrates including many xenobiotics, steroids,fatty acids, vitamins and prostaglandins and catalyse reactions like hydroxylation, epoxidation, N-oxidation,sulfooxidation, N-, S- and O-dealkylations, desulfation,deamination, and reduction of azo, nitro, and N-oxide groups.; Function: the cytochrome P450 monooxygenase lovA of A. terreus is involved in the biosynthesis of polyketides,the ubiquitous products of secondary metabolism in microorganisms.; Similarity: the ORF shows similarity to several cytochrome P450 homologs from different species and with various specificity.; Title: strong similarity to cytochrome P450 monooxygenase lovA - Aspergillus terreus; See PMID 10334994
An08g00190	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 103 amino acids.; Title: questionable ORF
An08g00200	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 65 amino acids.; Title: questionable ORF
An08g00210	Catalytic activity: gpm1 of M. musculus catalyses Sn-glycerol 3-phosphate + acceptor = glycerone phosphate (dihydroxyacetone phosphate) + reduced acceptor.; Induction: calcium-binding enhances the activity of gpm1 from M. musculus and FAD is used as cofactor.; Pathway: gpm1 of M. musculus is involve in glycerol metabolism and is part of the mitochondrial glycerol phosphate shuttle in conjunction with an NAD-dependent cytoplasmic GPD and the anaerobic respiration machine.; Remark: a splice site was detected upstream of the START codon.; Remark: gpm1 of M. musculus is also called GPD-M,GPDH-M or GPD2.; Title: strong similarity to glycerol-3-phosphate dehydrogenase gdm1 - Mus musculus; localisation:mitochondrion; See PMID 8951039
An08g00220	Function: amino acid permease mtr of N. crassa is required for the transport of neutral amino acids and aromatic amino acids via the N-system.; Similarity: the similarity of the ORF to amino acid permease of N. crassa is restricted to its N-terminal amino acids, ending around position 240.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa [truncated ORF]
An08g00230	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 44 amino acids.; Title: questionable ORF
An08g00270	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 84 amino acids.; Title: questionable ORF
An08g00280	Similarity: the ORF shows strong similarity to the unnamed ORF with cDNA FLJ14994 fis, clone Y79AA1002125 of H. sapiens.; Title: strong similarity to hypothetical protein BAB55442.1 - Homo sapiens
An08g00290	Function: rud3 of S. crevisiae is involved in protein translocation from the ER to golgi and complements a mutant phenotype found in sec35-2 (vesicle tethering protein) strains.; Phenotype: S. cerevisiae rud3 null mutant shows severe growth defect or inviability in combination with many ER-to-Golgi transport mutants, such as uso1-1, sec34,sec35-1, sec22-3, and bos1-1.; Remark: rud3 of S. cerevisiae is also called GRP1 or YOR216C.; Title: strong similarity to golgin-160 related protein Rud3 - Saccharomyces cerevisiae; See PMID 10562277
An08g00300	Catalytic activity: guanylate kinases catalyze ATP + GMP <=> ADP + GDP.; Function: guanylate kinases catalyse the reversible transfer of the terminal phosphoryl group of ATP to the acceptor molecule GMP to recycle GMP and indirectly cGMP.; Phenotype: S. cerevisiae guk1 null mutants show adenine derepression, purine excretion, and 8-azaguanine resistance.; Phenotype: allelic mutants of guk1 from S. cerevisiae (bra3) show GMP accumulation and feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), encoded by the HPT1 gene.; Remark: guk1 of S. cerevisiae is also called pur5 or YDR454C.; Title: strong similarity to guanylate kinase Guk1 -Saccharomyces cerevisiae; See PMID 1334480; See PMID 1967656; See PMID 2551688
An08g00310	Function: aspD of A. nidulans belongs to the highly conserved septin family of presumably cytoskeletal proteins involved in cytokinesis and morphogenesis.; Remark: all known A. nidulans septins, including all asp products except that of aspD, contain predicted coiled-coil domains at or near the carboxyl termini.; Similarity: the ORF shows similarity to cell division control proteins from different species.; Title: strong similarity to septin aspD -Aspergillus nidulans; See PMID 10481176; See PMID 11181167; See PMID 11238387
An08g00320	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 39 amino acids.; Title: questionable ORF
An08g00330	Function: ribosomal protein L32p is part of the 50 S ribosomal subunit of pro- and eukaryotes, the S. cerevisiae protein binds to and regulates the splicing and the translation of the transcript of its own gene.; Remark: YmL32 of S. cerevisiae is also called MRPL32, YCR003W, YCR041 or YCR3W.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml32 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8366109; See PMID 9121443; See PMID 3316213
An08g00340	Function: rec14 of S. pombe is essential for meiotic recombination.; Title: strong similarity to meiotic recombination protein rec14p - Schizosaccharomyces pombe; See PMID 9752725
An08g00350	Title: strong similarity to hypothetical protein SPCC188.04c - Schizosaccharomyces pombe
An08g00360	Complex: transcription initiation factor RRN6 of S. cerevisiae forms a heterotrimeric complex with RRN7 and a 66kD protein, which may further dimerize to form a hexamer.; Function: the heterotrimeric complex is essential for the initiation of rDNA transcription by RNA polymerase I. binding to the DNA template is dependent on the initial binding of other factors.; Title: similarity to transcription initiation factor Rrn6 - Saccharomyces cerevisiae; See PMID 7958901
An08g00370	Remark: HAH1 is a ubiquitously expressed protein,which plays an essential role in antioxidant defense and copper homeostasis in humans.; Title: strong similarity to copper transport protein HAH1 - Homo sapiens; See PMID 9083055
An08g00380	Similarity: only N-terminal 250 aa show similarity to An01g10240.; Title: similarity to hypothetical protein CAD70412.1 - Neurospora crassa
An08g00390	Title: similarity to hypothetical protein SPAC806.05 - Schizosaccharomyces pombe
An08g00400	Title: strong similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe
An08g00410	Title: similarity to hypothetical protein BAA92131.1 - Homo sapiens
An08g00420	Remark: ciao-1 is a Wilms' tumour (WT1) binding protein. Products of the invention can be used for identifying agents which modulate the expression or activity of the Wilm's tumour suppressor gene, WT1. The products can be used for treating e. g. tumours,endometriosis, ependymonas, for transplantation of organs,for treating degenerative disorders of lung tissue caused by e. g. toxic injuries, as well as inflammatory and degenerative processes induced by viral infections.; Title: strong similarity to ciao-1 protein s from patent WO9813494-A2 - Homo sapiens
An08g00430	Catalytic activity: preferential release of a C-terminal arginine or lysine residue.; Function: the S. cerevisiae homolog Kex1p is a type I transmembrane carboxypeptidase involved in precursor processing within the yeast secretory pathway.; Golgi; Remark: S. cerevisiae Kex1p has a broad specificity with optimum pH 4. 5-6. 0.; Repression: Kex1p is inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents.; Title: strong similarity to precursor of carboxypeptidase Kex1 - Saccharomyces cerevisiae
An08g00440	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein YOR021c - Saccharomyces cerevisiae
An08g00450	Title: strong similarity to hypothetical protein SPAC10F6.16 - Schizosaccharomyces pombe
An08g00470	Title: strong similarity to hypothetical protein SPAC23C11.01 - Schizosaccharomyces pombe
An08g00480	Title: strong similarity to hypothetical protein BAB23171.1 - Mus musculus
An08g00490	Catalytic activity: D-glucono-1,5-lactone + H(2)O <=> D-gluconate.; Remark: Acts on a wide range of hexono-1,5-lactones.; Remark: Also involved in ascorbate and aldarate metabolism, caprolactam degradation.; Title: strong similarity to lactonohydrolase -Fusarium oxysporum; See PMID 9788992
An08g00500	Title: similarity to hypothetical protein CAD70990.1 - Neurospora crassa
An08g00510	Title: strong similarity to cytosolic methionine--tRNA ligase Mes1 - Saccharomyces cerevisiae
An08g00520	Function: sonA protein of A. nidulans is involved in the nuclear localization of the NIMXCDC2/ NIMECyclin B complex.; Localization: SONA-HA staining pattern is similar to the nuclear pore-like staining pattern seen for GLE2.; Remark: a splice site was detected upstream of the START codon.; Remark: mutations in sonA were identified as allele-specific suppressors of serine/threonine protein kinase nimA1.; Similarity: the predicted A. niger protein shows strong similarity to the sonA protein of A. nidulans and homologues Rae1/Gle2 of diverse eucaryotic organisms.; Title: strong similarity to protein sonA -Aspergillus nidulans; See PMID 9647650
An08g00540	Title: strong similarity to EST SEQ ID NO:4140 from patent WO200056762-A2 - Aspergillus niger
An08g00550	Protein sequence is in conflict with the conceptual translation; Function: Essential for mitotic growth. Mediates organelle inheritance.; Similarity: S. cerevisiae MDM1 protein has low similarity to vimentins and other intermediate filaments.; Title: strong similarity to protein Mdm1 -Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 1378448
An08g00560	Catalytic activity: phosphatidyl-N-methylethanolamine N-methyltransferases catalyze the conversion of S-adenosyl-L-methionine + phosphatidyl-ethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-n-methylethanolamine.; Function: phosphatidyl-N-methylethanolamine N-methyltransferase OPI3 of S. cerevisiae catalyzes the Second and third steps of methylation pathway for phosphatidylcholine biosynthesis.; Title: strong similarity to phosphatidyl-N-methylethanolamine N-methyltransferase Opi3 - Saccharomyces cerevisiae; See PMID 8431960; See PMID 11078727
An08g00570	Title: weak similarity to dentin matrix acidic phosphoprotein 1 DMP1 - Homo sapiens
An08g00580	Title: similarity to hypothetical protein CG14966 -Drosophila melanogaster
An08g00590	Similarity: aminoacids 523 to 641 show similarity to N-terminal third of Rv3312c of M. tuberculosis.; Title: weak similarity to hypothetical protein Rv3312c - Mycobacterium tuberculosis
An08g00600	Function: glutaredoxins and thioredoxins are ubiquitous small heat-stable oxidoreductases that have proposed functions in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding and sulphur metabolism.; Similarity: shows similarity to several glutaredoxin and glutaredoxin-like proteins.; Title: similarity to glutaredoxin - Oryza sativa; See PMID 8430514; See PMID 11169096
An08g00610	Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L9.b - Saccharomyces cerevisiae; cytoplasm; See PMID 9559554
An08g00620	Title: similarity to hypothetical protein SPCC1450.16c - Schizosaccharomyces pombe
An08g00630	Function: HNM1 of S. cerevisiae is the yeast cholin transporter.; Similarity: shows similarity to several putative and known aminoacid, GABA, and cholin transporter.; Title: similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8264542; See PMID 7520996
An08g00640	Title: similarity to hypothetical protein YGR266w -Saccharomyces cerevisiae
An08g00670	Similarity: shows only similarity to other protein in the C-terminal region containing the rhomboid family domain.; Title: similarity to hypothetical membrane protein YGR101w - Saccharomyces cerevisiae
An08g00690	Function: Mob1p of S. cerevisiae is required for completion of mitosis and maintenance of ploidy.; Title: similarity to completion of mitosis and maintenance of ploidy protein Mob1 - Saccharomyces cerevisiae; See PMID 9436989
An08g00700	Title: similarity to hydrophilic proteasome interacting protein Leo1 - Saccharomyces cerevisiae
An08g00710	Similarity: the predicted ORF is only similar to a small region of the N-terminus of A. parasiticus alfR.; Title: weak similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus
An08g00720	Remark: functional annotation of ERB1 was transferred from the SGD database.; Remark: the systematic genename of ERB1 is YMR049c.; Title: strong similarity to conserved eukaryotic protein involved in ribosome biogenesis Erb1 -Saccharomyces cerevisiae
An08g00730	Complex: the native rat TER ATPase has been characterized as a hexamer of six 100-kD subunits by gel filtration.; Function: AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport.; Function: the rat protein has been isolated as an ATPase with a monomer molecular weight of 100 kD by SDS-PAGE from TER and designated as TER ATPase.; Function: the transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,part-smooth transitional elements of the endoplasmic reticulum (TER).; Function: vesicle budding from the TER is an ATP-dependent process both in vivo and in vitro.; Similarity: shows strong similarity to several proteins of the AAA family of ATPases.; Title: similarity to transitional endoplasmic reticulum ATPase - Rattus norvegicus; See PMID 7806566; See PMID 9695811; See PMID 10893253
An08g00740	Function: deletion mutants of VPS20 stabilize Ste6 and show a 'class E vps phenotype'; Ste6, a member of the ABC-transporter family, is transported to the yeast vacuole for degradation.; Function: in deletion mutants of VPS20 maturation of the vacuolar hydrolase carboxypeptidase Y is affected and the endocytic tracer FM4-64 and Ste6 accumulate in a dot or ring-like structure next to the vacuole.; Remark: the systematic name of VPS20 is YMR077c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps20 - Saccharomyces cerevisiae; See PMID 11251082
An08g00750	Title: strong similarity to hypothetical conserved protein SPBP35G2.02 - Schizosaccharomyces pombe
An08g00760	Function: Prp22 of S. cerevisiae was shown to be involved in the release of spliced mRNAs from the spliceosomes.; Similarity: matches only to the C-terminal two thirds of Prp22p of S. cerevisiae; S. cerevisiae Prp22p is about 450 aminoacids longer at N-terminus. .; Similarity: shows strong similarity to several putative eukaryotic RNA helicases.; Title: similarity to RNA helicase Prp22 -Saccharomyces cerevisiae; nucleus; See PMID 10684925; See PMID 11230534
An08g00770	Title: similarity to hypothetical protein SPBC16E9.02c - Schizosaccharomyces pombe
An08g00780	Title: strong similarity to hypothetical protein AT4g09550 - Arabidopsis thaliana
An08g00790	Similarity: all homologs are longer at C-terminus.; Similarity: shows similarity to several putative acetyltransferases.; Title: similarity to hypothetical acetyltransferase F21B7.10 - Arabidopsis thaliana
An08g00800	Similarity: C-terminal half shows similarity to AF-4 protein of M. musculus.; Similarity: N-terminal half shows similarity to Axl2p (YIL140W) of S. cerevisiae.; Title: similarity to plasma membrane glycoprotein Axl2 - Saccharomyces cerevisiae; See PMID 8846915; See PMID 9732282; See PMID 10366591
An08g00810	Similarity: shows similarity to several resistance proteins.; Title: similarity to tetracyclin resistance protein TetH - Pasteurella multocida; See PMID 8109938
An08g00830	Function: Ptc2p of S. cerevisiae downregulates the UPR (unfolded-protein response) by dephosphorylating Ire1p and reveal a novel mechanism of regulation in the UPR pathway upstream of the HAC1 mRNA splicing event.; Function: Ptc2p of S. cerevisiae is involved in the DNA checkpoint pathways.; Pathway: unfolded protein response pathway; cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing the transcription of the genes encoding ER-resident chaperone proteins.; Similarity: all homologs are 36 aminoacids longer at N-terminus.; Title: strong similarity to protein phosphatase type 2C Ptc2 - Saccharomyces cerevisiae; See PMID 9528768; See PMID 10440230; See PMID 10747050
An08g00840	Catalytic activity: choline-phosphate cytidylyltransferase catalyzes the conversion of CTP + choline phosphate = pyrophosphate + CDP choline.; Pathway: choline-phosphate cytidylyltransferase is involved in phospholipid biosynthesis.; Title: similarity to choline-phosphate cytidylyltransferase Pct1 - Saccharomyces cerevisiae; See PMID 11078727; See PMID 2826147
An08g00850	Title: weak similarity to hypothetical protein encoded by An13g00450 - Aspergillus niger
An08g00860	Title: strong similarity to hypothetical membrane protein YMR253c - Saccharomyces cerevisiae
An08g00870	Title: strong similarity to hypothetical protein 1A9.230 - Neurospora crassa
An08g00880	Function: the presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles.; Similarity: p40 and p47 subunits of eIF3 are shown to be homologues of the proteasome subunit Mov34, and transcriptional regulators JAB1/pad1.; Similarity: shows also strong similarity to probable 26s proteasome regulatory subunits.; Title: strong similarity to hypothetical branched-chain alpha-ketoacid dehydrogenase E1 beta subunit - Homo sapiens; See PMID 9341143; See PMID 9605331
An08g00890	Complex: S. cerevisiae TFIID is composed of TBP, the TATA box binding protein, and 14 distinct TBP-associated factors (TAFs), which range in size from 17 to 150 kDa.; Function: in eukaryotic cells the TATA-binding protein (TBP) associates with other proteins known as TBP-associated factors (TAFs) to form multisubunit transcription factors important for gene expression by all three nuclear RNA polymerases.; Remark: the alternate genename of S. cerevisiae TAF19 is FUN81.; Title: strong similarity to subunit of transcription initation factor TFIID Taf19 - Saccharomyces cerevisiae; nucleus; See PMID 8962109; See PMID 10721692; See PMID 10864925
An08g00900	Remark: putative sequencing error, 1 bp too much.; Title: strong similarity to hypothetical protein BAB22431.1 - Mus musculus [putative frameshift]; putative frameshift
An08g00910	Title: similarity to hypothetical membrane-associated salt-inducible protein OSJNBa0055P24.12 - Oryza sativa
An08g00920	Title: strong similarity to hypothetical protein 1A9.290 - Neurospora crassa
An08g00930	Similarity: the predicted ORF may be N-terminally too short.; Title: weak similarity to hypothetical protein CAB88521.3 - Neurospora crassa
An08g00940	Title: strong similarity to hypothetical protein 1A9.260 - Neurospora crassa
An08g00950	Complex: YmL8 of S. cerevisiae is a mitochondrial ribosomal protein of the large subunit.; Remark: YmL8 of S. cerevisiae is also called MRPL8,L17, YJL063C, J1125, or HRD238.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml8 - Saccharomyces cerevisiae; localisation:mitochondrion
An08g00960	Title: strong similarity to hypothetical protein AD11338.1 - Neurospora crassa
An08g00970	Complex: ribosomal protein S12 is one of the proteins from the small ribosomal subunit.; Gene-ID: rps28; Remark: a splice site was detected upstream of the START codon.; cytoplasm
An08g00980	Complex: the guanine nucleotide exchange factor for eIF-2 in S. cerevisiae is a complex of five different subunits; alpha (GCD3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).; Function: Gcd7p of S. cerevisiae is a subunit of the guanine nucleotide exchange factor for eIF-2.; Function: Gcd7p of S. cerevisiae is required to repress GCN4 translation under nonstarvation conditions.; Title: strong similarity to translation initiation factor eIF2B guanine nucleotide exchange factor 43 kDa subunit Gcd7 - Saccharomyces cerevisiae; See PMID 8506384; See PMID 9472020
An08g00990	Function: NEM1 of S. cerevisiae required for correct nuclear morphology.; Remark: YHR004C is an alternativ name for NEM1.; Remark: a splice site was detected upstream of the START codon.; Remark: the region of similarity of the ORF encoded protein to NEM1 of S. cerevisiae is restricted to the C-terminus.; Similarity: C-terminal 200 residues of the ORF encoded protein and of NEM1 show similarity to the C-termini of YLL010c, YLR019w, YPL063w, hypothetical C. elegans and S. pombe and human proteins; Title: similarity to Nem1 - Saccharomyces cerevisiae; See PMID 9822591
An08g01000	Catalytic activity: aspC of M. thermoformicicum catalyzes the reaktion of L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Remark: aspartate transaminase also acts on L-tyrosine, L-phenylalanine and L-tryptophan; this activity can be formed from EC 2. 6. 1. 57 by controlled proteolysis.; Remark: the ORF encoded protein also shows similarity to other transaminases.; Title: strong similarity to aspartate transaminase aspC - Methanobacterium thermoformicicum; See PMID 8206881
An08g01020	Title: strong similarity to hypothetical protein YJL055w - Saccharomyces cerevisiae
An08g01030	Complex: in S. cerevisiae Vps35p and Vps29p interact and form part of a multimeric membrane-associated complex,designated as the retromer complex, that also contains Vps26p, Vps17p, and Vps5p.; Function: Vps29p of S. cerevisiae is a component of the sorting machinery required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor Vps10p.; Function: experiments with S. cerevisiae suggest a model in which Vps35p/Vps29p/Vps26p function to select cargo for retrieval, and Vps5p/Vps17p assemble onto the membrane to promote vesicle formation.; Golgi; Title: strong similarity to vacuolar protein sorting protein Vps29 - Saccharomyces cerevisiae; See PMID 9700157
An08g01040	Function: in D. melanogaster Pabp2 stimulates poly(A) polymerase and is able to control poly(A) tail length.; Title: strong similarity to poly(A)-binding protein II Pabp2 - Drosophila melanogaster; nucleus; See PMID 10481015
An08g01050	Title: weak similarity to hypothetical protein P0504H10 - Oryza sativa
An08g01060	Function: S. pombe pub1 either directly or indirectly regulates membrane transport processes and membrane permease turnover.; Function: in S. pombe the E3 ubiquitin protein ligase Pub1 ubiquinates the mitotic activating tyrosine phosphatase cdc25, thereby regulating cdc25 levels and activity.; Title: strong similarity to ubiquitin protein ligase ub1p - Schizosaccharomyces pombe; See PMID 8635463; See PMID 9197411
An08g01070	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An08g01080	Title: similarity to hypothetical protein F28J15.5 -Arabidopsis thaliana
An08g01090	Complex: in S. cerevisiae AHC1 is part of the 0. 8-MDa ADA complex which also contains the adapter proteins Ada2, Ada3, and Gcn5.; Function: S. cerevisiae AHC1 in high copy numbers suppresses the cold sensitivity caused by particular mutations in HTA1 which encodes histone H2A.; Remark: YOR023c is the systematic name for AHC1.; Title: similarity to Ada Histone acetyltransferase complex component Ahc1 - Saccharomyces cerevisiae; nucleus; See PMID 10490601
An08g01100	Catalytic activity: glucan 1,3-beta-glucosidases catalyse the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: disruption of K. lactis KlEXG1 did not result in a phenotype under laboratory conditions.; Function: in S. cerevisiae overexpression of EXG1 on a 2 mu plasmid led to reduction in a cell wall beta 1,6-glucan and caused killer resistance in wild type cells.; Title: strong similarity to exo-1,3-beta-glucanase KlEXG1 - Kluyveromyces lactis; extracellular/secretion proteins; See PMID 10029988; See PMID 7565587
An08g01110	Function: VTC1 of S. cerevisiae is involved in the distribution of V-ATPase and other membrane proteins.; Function: in S. pombe Nrf1p functions as a negative regulator of Cdc42p within the cell polarity pathway.; Function: in S. pombe overexpression of nrf1(+) resulted in dose-dependent lethality, with cells exhibiting an ellipsoidal morphology indicative of loss of polarized cell growth along with partially delocalized cortical actin and large vacuoles.; Function: null mutations of S. cerevisiae VTC1 cause pleiotropic effects on metal-ion resistance or sensitivity and distribution of membrane proteins in different targets.; Remark: the systematic name for VTC1, which is also known as NRF1, is YER072W.; Title: strong similarity to Vtc1 - Saccharomyces cerevisiae; See PMID 10480897; See PMID 10628977
An08g01120	Function: isoJ from Rhodococcus sp. is placed in a metabolic pathway representing a catabolic route for isoprene involving epoxidation by a monooxygenase,conjugation to glutathione, and oxidation of the hydroxyl group to a carboxylate.; Function: isoJ from Rhodococcus sp. shows activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1,2-epoxy-2-methyl-3-butene.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003
An08g01130	Function: aph(2'')-Id from E. casseliflavus is an aminoglycoside-modifying phosphotransferase confering gentamicin resistance. .; Title: similarity to gentamicin resistance gene aph(2)-Id - Enterococcus casseliflavus; See PMID 9593155
An08g01140	Function: in S. pombe Dlc1 is required for the function of the telomere associated-spindle pole body.; Remark: information regarding S. pombe Dlc1 has not yet been published and is available via http://www. sanger. ac. uk/cgi-bin/yeastpub/GN_KW_search. p.; Similarity: S. pombe Dlc1 is similar to human TCTEX-1 dynein light chain.; Title: strong similarity to cytoplasmic dynein light chain dlc1p - Schizosaccharomyces pombe; cytoskeleton
An08g01150	Function: LST8 from S. cerevisiae is required for amino acid permease transport from the Golgi to the cell surface.; Remark: YNL006w is the systematic name for LST8.; Remark: information regarding LST8 from S. cerevisiae has not yet been published and is available via the SGD database at http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: the predicted A. niger protein shows high similarity to members of the WD-40 repeat G-beta transducin family.; Title: strong similarity to G beta-like protein Lst8 - Saccharomyces cerevisiae
An08g01160	Similarity: the Syndecan family shares transmembrane domains, while none are predicted for the A. niger protein.; Title: weak similarity to heparin sulfate proteoglycan syndecan Sdc - Drosophila melanogaster; See PMID 8159748
An08g01170	Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe
An08g01180	Title: strong similarity to hypothetical protein SC4G1.04c - Streptomyces coelicolor
An08g01190	Catalytic activity: catalyse the reaction,Acetyl-CoA + peptide <=> CoA + N-acetylpeptide.; Complex: in S. cerevisiae Ard1 forms a complex with Nat1 and ARD1-ARD1 homodimers.; Function: in S. cerevisiae Ard1 and Nat1 are required for the N-terminal acetyltransferase activity,with Nat1 representing the catalytic subunit.; Function: in S. cerevisiae Ard1 is required for full repression of the silent mating type locus HML, for sporulation, and for entry into G0.; Remark: polymorphism in the human peptide alpha-N-acetyl transferases NAT1 and NAT2 are associated with cancer susceptibility.; Title: strong similarity to subunit of the major N alpha-acetyltransferase Ard1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1600941
An08g01200	Similarity: predicted A. niger protein shows likely unspecific similarity to proline rich proteins.; Title: weak similarity to hydroxyproline-rich glycoprotein - Nicotiana tabacum
An08g01210	Remark: the predicted A. niger protein shows strong similarity to a eucaryotic kinase domain from the Pfam database as well as to a ser/thr protein kinase group of COGs.; Title: strong similarity to hypothetical 105-kDa kinase-like protein - Mus musculus
An08g01220	Function: Myb is a DNA-binding transcriptional regulator.; Similarity: the predicted A. niger protein is 200 aa shorter than OSMYB2 from O. sativa.; Title: weak similarity to myb-related protein 2 OSMYB2 - Oryza sativa
An08g01230	Function: in S. cerevisiae Pbp1p appears to function in the nucleus to promote proper polyadenylation.; Remark: the systematic name for Pbp1 of S. cerevisiae is YGR178C.; Title: similarity to poly(A)-binding protein interacting factor Pbp1 - Saccharomyces cerevisiae; nucleus; See PMID 9819425
An08g01240	Complex: in S. cerevisiae Gic2p is a Cdc42p effector and interacted with Aip3p by coimmunoprecipitation and two-hybrid analysis.; Function: AIP3/BUD6 from S. cerevisiae is not essential for mitotic growth but is necessary for normal morphogenesis and deletion of AIP3 causes gross defects in cell and cytoskeletal polarity.; Localization: Aip3p from S. cerevisiae localizes at the cell cortex where cytoskeleton assembly must be achieved to execute polarized cell growth.; Localization: in S. cerevisiae Aip3p localization is mediated by the secretory pathway.; Remark: AIP3 from S. cerevisiae is also known as BUD6.; Title: similarity to actin-interacting protein Aip3 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9247651; See PMID 10938101
An08g01250	Function: CIP7 from A. thaliana acts as a positive regulator of light-regulated genes and is a potential direct downstream target of COP1 for mediating light control of gene expression.; Function: CIP7 from A. thaliana is a novel nuclear protein that contains transcriptional activation activity without a recognizable DNA binding motif.; Similarity: similarity is from N-terminal 100 aa of predicted A. niger protein to central part of CIP7 from A. thaliana.; Similarity: the N-terminal 100 aa of predicted A. niger protein also show similarity to C-terminus of the DEAD box RNA helicase CHR1 from Candida albicans.; Title: weak similarity to COP1-interacting protein 7 CIP7 - Arabidopsis thaliana; See PMID 9668129
An08g01260	Catalytic activity: TH4 from Pinus taeda catalyses the NADPH-dependent reduction of phenylcoumaran benzylic ethers.; Function: TH4 from T. heterophylla is involved in the biosynthesis of important phenylpropanoid-derived plant defense compounds.; Title: similarity to phenylcoumaran benzylic ether reductase TH4 - Tsuga heterophylla; See PMID 10066819
An08g01270	Catalytic activity: gamma-glutamylcysteine synthetases catalyse the reaction, ATP + L-glutamate + L-cysteine <=> ADP + phosphate + gamma-L-glutamyl-L-cysteine.; Function: S. pombe GSH1 encodes the rate-limiting step in glutathione biosynthesis.; Function: The tripeptide gamma-L-glutamyl-L-cystinylglycine (glutathione) is one of the major antioxidant molecules of cells and is thought to play a vital role in buffering the cell against reactive oxygen species and toxic electrophiles.; Induction: expression of S. pombe GSH1 is activated by the yAP-1 transcriptional regulatior.; Induction: in S. cerevisiae the transcription factors Met-4, Met-31, and Met-32 are essential for cadmium-mediated regulation of GSH1 expression.; Repression: in S. cerevisiae the DNA-binding protein Cbf1 appears to play a negative role in controlling GSH1 expression.; Title: strong similarity to gamma-glutamylcysteine synthase gcs1p - Schizosaccharomyces pombe; See PMID 10921921; See PMID 7915005
An08g01280	Title: weak similarity to hypothetical protein BH1676 - Bacillus halodurans
An08g01290	Complex: in S. cerevisiae ArgRI and Mcm1, two MADS-box proteins, and ArgRII form a three-component protein complex.; Function: ArgRII of S. cerevisiae is the sensor of the effector arginine.; Function: in S. cerevisiae repression of arginine anabolic genes and induction of arginine catabolic genes are mediated by a three-component protein complex,interacting with specific DNA sequences in the presence of arginine.; Similarity: ArgRII of S. cerevisiae is a zinc cluster protein with an arginine binding domain.; Similarity: similarity from predicted A. niger protein to S. cerevisiae ArgRII, which is 400 aa longer, is restricted to the N-terminal 100 aa of each protein.; Title: weak similarity to regulator protein Arg81 -Saccharomyces cerevisiae; See PMID 10688655
An08g01300	Remark: fructosyl amino acid oxidase is an enzyme that can be used for the determination of glycated proteins in blood samples from diabetic patients.; Remark: fructosyl amino acid oxidase was found only in the strains of four genera of fungi, Aspergillus,Fusarium, Gibberella, and Penicillium.; Remark: patents for fructosyl amino acid oxidase from different fungal strains exist.; Title: strong similarity to fructosyl amino acid oxidase faop - Penicillium janthinellum; See PMID 8534116; See PMID 9022674; See PMID 9139700
An08g01310	Function: in S. cerevisiae mutants (dal5) that lack allantoate transport have been isolated, these strains also exhibit a 60% loss of allantoin transport capability.; Regulation: in S. cerevisiae Dal5 appears to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition.; Regulation: in S. cerevisiae allantoate uptake is constitutive.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3549700
An08g01320	Catalytic activity: 5-Oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290
An08g01330	Similarity: aa 252-319 of the predicted A. niger protein show a protein kinase signature.; Title: similarity to hypothetical protein F3E22.6 -Arabidopsis thaliana
An08g01340	Function: stcS from A. nidulans is required for the conversion of versicolorin A to sterigmatocystin.; Pathway: stcS of A. nidulans is involved in sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: stcS (formerly verB) from A. nidulans belongs to the P-450 monooxygenase superfamily.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 10618248; See PMID 7486998
An08g01350	Complex: in vitro SRPKs bound unphosphorylated SF2/ASF but did not bind phosphorylated SF2/ASF.; Function: SRPKs may have regulatory roles in the assembly and localization of Serine/arginine-rich (SR) splicing factors like SF2/ASF.; Function: in human HeLa cells expression of an SRPK2 kinase-inactive mutant caused accumulation of SF2/ASF in the cytoplasm.; Title: similarity to serine/threonine protein kinase SRPK1 - Arabidopsis thaliana; cytoplasm; deleted EC_number 2.7.1.37; See PMID 10196197
An08g01360	Title: similarity to hypothetical protein G11A3.030 - Neurospora crassa
An08g01370	Function: Odc2 from S. cerevisiae is a mitochondrial 2-oxodicarboxylate transport protein.; Function: S. cerevisiae Odc2 transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria in a strict counter-exchange mechanism.; Function: the main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate respectively, and in lysine catabolism.; Remark: the ALOM Algorithm does not predict transmembrane regions for the predicted A. niger protein,while Algorithms used by Swissprot predict TM regions for the nearly identical S. cerevisiae aa sequence.; Similarity: Odc1 and Odc2 from S. cerevisiae is a member of the family of mitochondrial carrier proteins.; Title: strong similarity to Oxodicarboxylate carrier Odc2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11013234
An08g01380	Function: the mutation of glcd in A. nidulans leads to a loss of mitochondrial FAD-dependent sn-glycerol-3-phosphate dehydrogenase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to transcriptional activator glcD - Aspergillus nidulans; See PMID 2259335
An08g01390	Function: in A. thaliana GBF2 binds to the g-box motif (5'-ccacgtgg-3') of the rbcs-1a gene promoter.; Similarity: A. thaliana GBF2 contains a basic leucine-zipper motif.; Similarity: only central region of predicted A. niger protein shows similarity to central region of A. thaliana GBF2.; Title: weak similarity to g-box binding factor 2 GBF2 - Arabidopsis thaliana [truncated ORF]; See PMID 1373374
An08g01392	Remark: the ORF is N-terminally truncated due to border of contig.
An08g01410	Function: Sft2p of S. cerevisiae is membrane protein involved in traffic to the Golgi complex.; Remark: systematic genename of SFT2 is YBL102w.; Title: strong similarity to ER-Golgi transport protein Sft2 - Saccharomyces cerevisiae; See PMID 10406798
An08g01420	Catalytic activity: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate.; Pathway: anthranilate synthase catalyzes the first step in biosynthesis of tryptophan.; Title: similarity to anthranilate synthase component I trpE - Clostridium thermocellum; See PMID 2732211
An08g01430	Title: weak similarity to hypothetical protein Rv0598c - Mycobacterium tuberculosis
An08g01440	Title: similarity to hypothetical protein SCD19.11 -Streptomyces coelicolor
An08g01460	Title: similarity to hypothetical transcriptions regulator CAB91400.2 - Neurospora crassa
An08g01480	Remark: The tRNA ligase TRL1 of S. cerevisiae is one of the components required for splicing of yeast tRNA precursors in vitro.; Title: strong similarity to tRNA ligase Trl1 -Saccharomyces cerevisiae; See PMID 3512545; See PMID 3277966
An08g01490	Title: similarity to hypothetical ankyrin-repeat protein SPCP1E11.10 - Schizosaccharomyces pombe
An08g01500	Title: weak similarity to hypothetical protein T4D2.50 - Arabidopsis thaliana
An08g01510	Function: Dpp1p of S. cerevisiae contains diacylglycerol pyrophosphate (DGPP) phosphatase and Mg2+-independent phosphatidate (PA) phosphatase activity.; Remark: systematic genename of S. cerveisiae DPP1 is YDR284c.; Title: similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 11016943; See PMID 11139591
An08g01520	Catalytic activity: Alcohol + NADP(+) = Aldehyde + NADPH.; Remark: Alcohol dehydrogenase is identical with aldehyde reductase.; Similarity: belongs to the Aldo/Keto reductase family.; Title: strong similarity to alcohol dehydrogenase (NADP+) ALR - Sus scrofa; See PMID 7552731; See PMID 9329083
An08g01540	Title: similarity to hypothetical protein PA4177 -Pseudomonas aeruginosa
An08g01550	Remark: S. cerevsisiae cox19 defect affects specifically the cytochrome oxidase activity in mitochondria.; Remark: it is assumed that YLL018c-a (COX19) of S. cerevisiae acts as cytochrome c oxidase subunit, as an S. cerevisiae clone containing this region complements respiratory deficient mutants of group G188 (Dr. A. Tzagoloff).; Title: strong similarity to hypothetical subunit of probable cytochrome c oxidase Cox19 - Saccharomyces cerevisiae
An08g01560	Title: similarity to hypothetical protein SPBC543.04 - Schizosaccharomyces pombe
An08g01580	Function: rat Nopp140 is a nucleolar phosphoprotein of 140 kd that was originally identified and purified as a nuclear localization signal (NLS)-binding protein.; Function: rat Nopp140 is one of the most phosphorylated proteins in the cell, and NLS binding was dependent on phosphorylation.; Function: rat Nopp140 was shown to shuttle between the nucleolus and the cytoplasm and is suggested to function as a chaperone for import into and/or export from the nucleolus.; Similarity: shows also some similarity to the S. cerevisiae SRP40 gene product which is immunologically and structurally related to rat Nopp140.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein nopp140 - Rattus norvegicus; See PMID 8702624; See PMID 1623516
An08g01590	Remark: human SLP-2 may link stomatin or other integral membrane proteins to the peripheral cytoskeleton and thereby play a role in regulating ion channel conductances or the organization of sphingolipid and cholesterol-rich lipid rafts.; Title: similarity to membrane associated protein SLP-2 - Homo sapiens; See PMID 10713127
An08g01600	Complex: Hir1p and Hir2p f S. cerevisiae function as transcriptional corepressors that form a protein complex in vivo to regulate histone gene transcription.; Function: HIR1 and HIR2 of S. cerevisiae contain nuclear targeting signals and they play important roles in the transcription of six of the eight core histone genes during the S. cerevisiae cell cycle.; Function: The products of the HIR1 and HIR2 of S. cerevisiae genes have been defined genetically as repressors of histone gene transcription in S. cerevisiae.; Title: similarity to histone transcription regulator Hir1 - Saccharomyces cerevisiae; See PMID 8417331; See PMID 9001207
An08g01610	Title: strong similarity to hypothetical GTP-binding protein SPAC27E2.03c - Schizosaccharomyces pombe
An08g01620	Title: similarity to hypothetical protein YER007c-a - Saccharomyces cerevisiae
An08g01630	Title: similarity to hypothetical protein GH03694 -Drosophila melanogaster
An08g01640	Remark: human SGT interacts with the nonstructural protein NS1 of parvovirus H-1.; Title: strong similarity to small glutamine-rich tetratricopeptide protein SGT - Homo sapiens; See PMID 9557704; See PMID 9740675
An08g01650	Function: Mpi1p of S. cerevisiae is a component of the protein import system of the yeast mitochondrial inner membrane.; Function: Mpi1p of S. cerevisiae is a low abundance and constitutively expressed hydrophilic 48. 8 kDa protein that is essential for cell viability. Mpi1p is synthesized with a characteristic mitochondrial targeting sequence at its amino-terminus, which is most probably proteolytically removed during import.; Remark: The mitochondrial inner membrane import site protein ISP45 has been purified to homogeneity and identified as the product of the nuclear MPI1 gene.; Title: similarity to mitochondrial import protein Mpi1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8344245; See PMID 1396562
An08g01660	Title: similarity to mitochondrial ribosomal protein of the small subunit Yms18 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368
An08g01680	Title: similarity to hypothetical membrane protein YML002w - Saccharomyces cerevisiae
An08g01700	Title: similarity to protease inhibitor from patent WO9820133-A2 - Zea mays
An08g01710	Catalytic activity: alpha-L-arabinofuranosidases catalyze the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.; Function: Bacillus stearothermophilus T-6 produces an alpha-L-arabinofuranosidase when grown in the presence of L-arabinose, sugar beet arabinan, or oat spelt xylan.; Remark: The enzyme acts cooperatively with T-6 xylanase in hydrolyzing oat spelt xylan, and L-arabinose,xylose, and xylobiose are detected as the end reaction products.; Title: strong similarity to alpha-L-arabinofuranosidase abfA - Bacillus stearothermophilus; See PMID 7887599
An08g01720	Function: QUTD in A. nidulans facilitates the uptake of quinic acid into the mycelium thereby inducing the enzymes of the quinic acid utilizetion pathway.; Pathway: the quinic acid ulitization (qut) pathway in A. nidulans is a dispensable carbon utilization pathway that catabolizes quinate to protocatechuate via dehydroquinate and dehydroshikimate.; Similarity: also shows strong similarity to various sugar transporters of diverse species.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 8670107; See PMID 976880
An08g01730	Title: similarity to hypothetical protein CG14480 -Drosophila melanogaster
An08g01740	Function: GCY1 of S. cerevisiae encodes a putative glycerol dehydregonase (PubMed 9038161).; Function: uronate dehydrogenase of patent W29217 is used in L-ascorbic acid production from D-glucuronic or galacturonic acids.; Induction: GCY1 of S. cerevisiae is upregulated under salt stress conditions (PubMed 9038161).; Induction: GCY1 of S. cerevisiae is upregulated when galactose is the sole energy source but is low as soon as glucose is present (PubMed 2199324).; Pathway: GCY1 of S. cerevisiae is thought to be involved in glycerol dissimilation via dihydroxyaceton (PubMed 9038161).; Similarity: GCY1 of S. cerevisiae belongs to the family of NADPH-dependent aldo-keto reductases (PubMed 11306072).; Similarity: strong similarity to protein patent database entry GENESEQPROT:W29217.; Similarity: the sequence of uronate dehydrogenase of patent W29217 is identical to that of the GCY1 gene product of S. cerevisiae.; Title: strong similarity to uronate dehydrogenase from patent DE19604798-A1 - Saccharomyces cerevisiae; See PMID 9038161; See PMID 11306072; See PMID 2199324
An08g01750	Title: strong similarity to hypothetical protein EAA65867.1 - Aspergillus nidulans
An08g01760	Catalytic activity: exocellobiohydrolases cleave the beta-1,4 glycosidic bond releasing cellobiose from the non-reducing end of cellulose.; Pathway: fungal cellobiohydrolases are unique enzymes capable of degrading highly ordered cellulose.; Similarity: belongs to the cellulase family B (family 6 of glycosylhydrolases).; Similarity: shows also stong homology to cellulose 1, 4-beta-cellobiosidase (EC 3. 2. 1. 91) II (exocellobiohydrolase II, CBHII) of Trichoderma reesei (Hypocrea jecorina) - PubMed 8875646;3596237.; Similarity: strong similarity to protein patent database entry GENESEQPROT:W25789.; Title: strong similarity to cellulase from patent WO9733982-A1 - Acremonium cellulolyticus; extracellular/secretion proteins
An08g01770	Complex: the CK2 holoenzyme of S. pombe is a heterotetramer composed of an alpha and an alpha' catalytic chain and two beta regulatory chains.; Function: Ckb1 in S. pombe is a positive regulator of CK2 enzyme activity.; Function: casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.; Pathway: CK2 in S. pombe is a key regulatory enzyme involved in the control of various cellular processes including cell cycle progression and cell growth.; Similarity: casein kinase II is a highly conserved serine/threonine protein kinase that is ubiquitous in eukaryotic organisms.; Title: strong similarity to protein kinase CK2 (casein kinase II) beta subunit ckb1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 8264625; See PMID 9427841; See PMID 1099477
An08g01780	Title: strong similarity to hypothetical protein B14D6.320 - Neurospora crassa
An08g01790	Complex: TIF3H1 in A. thaliana is part of the heterodecameric eIF3 complex.; Function: eIF3 is required for binding of mRNA to 40S ribosomal subunits, stabilization of ternary complex binding to 40S subunits, and dissociation of 40S and 60S subunits.; Title: strong similarity to eukaryotic initiation factor 3H1 subunit TIF3H1 - Arabidopsis thaliana; cytoplasm; See PMID 11042177
An08g01800	Localization: putative transmembrane protein in the mitochondrial inner membrane.; Similarity: belongs to the mitochondrial carrier family.; Title: strong similarity to hypothetical mitochondrial carrier protein AgPET8 - Ashbya gossypii; See PMID 7941739
An08g01810	Remark: the ORF is N-terminally truncated due to end of contig.; Similarity: the N-terminus shows similarity to a broad variety of proline-rich proteins from diverse species.; Title: similarity to S-layer protein - Clostridium thermocellum [truncated ORF]
An08g01820	Remark: due to contig end.; Title: similarity to hypothetical potassium channel beta subunit - Rattus norvegicus [truncated ORF]
An08g01840	Title: weak similarity to hypothetical transcription factor - Vicia faba
An08g01850	Title: strong similarity to hypothetical DEAD/DEAH box RNA helicase SPCC10H11.01 - Schizosaccharomyces pombe
An08g01860	Remark: SUR1 from Candida albicans complements functional the S. cerevisiae rok1 mutation.; Title: strong similarity to ROK1-suppressor SUR1 -Candida albicans; See PMID 10705369
An08g01870	Title: weak similarity to hypothetical Pto kinase interactor F28B23.17 - Arabidopsis thaliana
An08g01890	Title: weak similarity to hypothetical cdk-activating kinase CAK4At - Arabidopsis thaliana
An08g01900	Catalytic activity: Hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini.; Remark: Also hydrolyses xylobiose.; Title: strong similarity to xylan 1,4-beta-xylosidase - Butyrivibrio fibrisolvens; See PMID 1905520
An08g01910	Catalytic activity: N1-acetylspermine + O(2) + H(2)O <=> N1-acetylspermidine + 3-amino-propanal + H(2)O(2); Cofactor: FAD, Iron.; Title: strong similarity to hypothetical polyamine oxidase PAO - Zea mays; See PMID 9598979
An08g01920	Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126
An08g01930	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH; Title: similarity to precursor of 3-oxoacyl-(acyl-carrier-protein) reductase - Cuphea lanceolata; See PMID 1376402
An08g01940	Title: strong similarity to hypothetical precursor of protein Y4OU - Rhizobium sp.
An08g01950	Title: strong similarity to hypothetical 30.2 KD protein Y4OV - Rhizobium sp.
An08g01960	Alternative name: S-adenosyl-L-homocysteine hydrolase.; Catalytic activity: S-adenosyl-L-homocysteine + H(2)O <=> adenosine + L-homocysteine; Title: strong similarity to adenosylhomocysteinase -Homo sapiens
An08g01970	Title: similarity to hypothetical protein encoded by An13g01600 - Aspergillus niger
An08g01980	Title: weak similarity to hypothetical protein CAC21410.1 - Schizosaccharomyces pombe
An08g01990	Complex: yeast Prp31p is associated both with the U4/U6 x U5 tri-snRNP and, independently, with the prespliceosome prior to assembly of the tri-snRNP into the splicing complex.; Function: yeast Prp31p is required for the processing of pre-mRNA species both in vivo and in vitro,indicating that the protein is directly involved in the splicing pathway. Prp31p seems to be involved in recruiting the U4/U6 x U5 tri-snRNP to prespliceosome complexes or in stabilizing these interactions.; Phenotype: wild-type PRP31 gene is essential for cell viability.; Similarity: the predicted A. niger protein shows strong similarity to pre-mRNA splicing protein PRP31 from S. cerevisiae and several hypothetical proteins from diverse eucaryotic species.; Title: strong similarity to pre-mRNA splicing protein Prp31 - Saccharomyces cerevisiae; See PMID 9199293
An08g02000	Title: strong similarity to hypothetical protein SPBC31F10.11c - Schizosaccharomyces pombe
An08g02020	Title: similarity to hypothetical protein encoded by An08g02050 - Aspergillus niger
An08g02030	Title: strong similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa
An08g02050	Title: similarity to hypothetical protein encoded by An08g02020 - Aspergillus niger
An08g02060	Title: similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa
An08g02080	Remark: the similarity to blastp matches is mainly due to repetitive amino acids.
An08g02090	Remark: the similarity to blastp matches is due to repetitive amino acids.
An08g02100	Function: guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.; Remark: a putative sequencing error results in an frameshift.; Similarity: gna-2 of N. crassa belongs to the G-alpha family.; Similarity: the ORF encoded protein shows similarity to many alpha subunits of G proteins.; Title: strong similarity to G protein alpha subunit gna-2 - Neurospora crassa [putative frameshift]; putative frameshift
An08g02110	Remark: a splice site was detected upstream of the START codon.; Remark: the ORF encoded protein shows similarity to many known and hypothetical zink finger transcription factors.; Title: similarity to factor of late activated T lymphocytes-1 RANTES - Homo sapiens; nucleus; See PMID 10023774
An08g02140	Title: questionable ORF
An08g02150	Title: questionable ORF
An08g02170	Remark: Similarity to other proteins is based on repetitive sequence motifs.
An08g02180	Catalytic activity: pyridoxine + NADP(+) <=> pyridoxal + NADPH.; Pathway: PLR of S. pombe is involved in the vitamin B6 metabolism.; Remark: alternate names for the S. pombe pyridoxine 4-dehydrogenase PLR : pyridoxal reductase; pyridoxin dehydrogenase; pyridoxine:NADP+ 4-oxidoreductase.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489; See PMID 10705982
An08g02190	Similarity: similarity to many DNA binding proteins.; Title: similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe
An08g02200	Function: hrp1 of S. pombe is required for proper chromosome segregation.; Remark: hrp1 of S. pombe is a member of the CHD protein family, characterized by a chromodomain, a Myb-like telobox-related DNA-binding domain and a SNF2-related helicase/ATPase domain.; Title: strong similarity to helicase-related protein hrp1p - Schizosaccharomyces pombe; See PMID 9520266; See PMID 10756203
An08g02210	Function: the equilibrium between RNase L inhibitor and its RNase target plays a central role in the regulation of mRNA turnover and protein biosynthesis.; Remark: ORF 5'truncated due to end of contig.; Remark: two possible sequencing errors at position 2382 and 2490, giving rise to stopcodons.; Similarity: Rnase L inhibitor is conserved in yeast,mouse, man.; Title: strong similarity to RNase L inhibitor - Homo sapiens [putative sequencing error] [truncated ORF]; putative sequencing error; See PMID 7539425
An08g02220	Remark: possible sequencing error at position 5783 leading to frame shift.; Remark: the systematic gene name of PRP40 of S. cerevisiae is YKL012w.; Similarity: the S. cerevisiae Prp40p is about 200 amino acids shorter at C-terminus.; Title: similarity to splicing factor Prp40 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 8622699; See PMID 10978320
An08g02230	Similarity: N-terminal 150 aminoacids show similarity to 200 aminoacids of the C-terminal part of MT2642 of M. tuberculosis.; Title: weak similarity to hypothetical protein MT2642 - Mycobacterium tuberculosis
An08g02240	Similarity: shows similarity to several peroxisomal membrane proteins.; Title: strong similarity to hypothetical peroxisomal organisation and biogenesis protein SPAC3G6.05 -Schizosaccharomyces pombe
An08g02260	Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.; Pathway: second step in the second phase of glycolysis.; Title: strong similarity to phosphoglycerate kinase pgkA - Aspergillus nidulans; See PMID 3533726
An08g02270	Title: strong similarity to hypothetical protein YDR363w-a - Saccharomyces cerevisiae
An08g02280	Title: strong similarity to hypothetical protein YKR018c - Saccharomyces cerevisiae
An08g02290	Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An08g02300	Remark: N-terminally truncated due to contig border.; Similarity: shows good similarity to C-terminus of enniatin synthetase of F. scirpi.; Title: weak similarity to enniatin synthase -Fusarium scirpi [truncated ORF]
An08g02310	Function: non-ribosomal peptide synthetases are large, multifunctional protein.; Pathway: production of HC-toxin, a cyclic tetrapeptide.; Remark: C-terminally truncated due to contig border.; Similarity: shows similarity to several known and hypothetical non-ribosomal peptide synthetase of different specificities.; Title: similarity to HC-toxin non-ribosomal peptide synthase HTS1 - Cochliobolus carbonum [truncated ORF]; See PMID 1281482; See PMID 1814363
An08g02320	Title: questionable ORF
An08g02330	Similarity: shows strong similarity to several known and hypothetical ABC-type multidrug transporter proteins with different specificities of different species.; Title: strong similarity to multidrug resistance protein MLP-2 - Rattus norvegicus; See PMID 9614210
An08g02340	Title: similarity to hypothetical protein SPBC3B9.16c - Schizosaccharomyces pombe
An08g02350	Function: the uvsC null mutant arrested at an earlier stage than the uvsC114 mutant, before the onset of meiosis; Function: the uvsC null mutant is sensitive to both UV and MMS.; Induction: transcription of uvsC from A. nidulans is induced by methyl-methane sulphonate (MMS).; Title: strong similarity to protein uvsC -Aspergillus nidulans; See PMID 9202381
An08g02390	Title: strong similarity to hypothetical conserved protein SPCP1E11.11 - Schizosaccharomyces pombe
An08g02400	Title: similarity to hypothetical protein B16B8.060 - Neurospora crassa
An08g02410	Title: weak similarity to extracellular matrix protein papilin Ppn - Drosophila melanogaster; See PMID 11076767
An08g02440	Catalytic activity: deoxynucleoside triphosphate + DNA(n) = pyrophosphate + DNA(n+1).; Pathway: purine metabolism; pyrimidine metabolism; DNA polymerase.; Remark: pol lambda has DNA polymerase activity in vitro and shares similar structural organization, including a BRCT domain, helix-loop-helix DNA-binding motifs and polymerase X domain. mRNA expression of pol lambda is highest in testis and fetal liver.; Similarity: belongs to the DNA polymerase IV (family X).; Title: similarity to DNA polymerase lambda POL lambda - Homo sapiens; See PMID 10982892
An08g02450	Remark: ATP10 S. cerevisiae is associated with the mitochondrial membrane but does not co-fractionate either with F1 or with the rutamycin-sensitive F1-F0 complex. These data suggest that the ATP 10 product is not a subunit of the ATPase complex but rather is required for the assembly of the F0 sector of the complex.; Remark: the predicted ORF is approximately 100 amino acids longer.; Title: similarity to mitochondrial protein Atp10 -Saccharomyces cerevisiae; See PMID 2141026
An08g02460	Remark: GOS1-disrupted cells suggests that Gos1p may play a role in multiple transport steps, specifically ER-Golgi and/or intra-Golgi transport.; Remark: Gos1p S. cerevisiae is a v-SNARE protein and localized to the Golgi compartment and likely homolog of the mammalian protein GOS-28/GS28. Gos1p is a type II membrane protein with characteristic SNARE sequence hallmarks and is functionally a SNARE protein.; Remark: alternate name is YHL031c.; Title: strong similarity to SNARE protein of Golgi compartment Gos1 - Saccharomyces cerevisiae; See PMID 9755865
An08g02470	Remark: hybridization of the cDNA to digests of nuclear DNA suggests that there are 15-17 copies of the L35 gene.; Remark: identical to EST SEQ ID NO:3904 and EST an_3657 from A. niger.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L35 - Rattus norvegicus; See PMID 2322279; See PMID 3426607
An08g02480	Title: strong similarity to hypothetical protein EAA65820.1 - Aspergillus nidulans
An08g02500	Remark: Schizosaccharomyces pombe hst4(+) gene is a member of the SIR2/HST silencing gene family that is defined in organisms ranging from bacteria to humans. Mutant strains show decreased silencing of reporter genes at both telomeres and centromeres. hst4(+) appears to be important for centromere function as well because mutants have elevated chromosome-loss rates and are sensitive to a microtubule-destabilizing drug. Consistent with a role in chromatin structure, Hst4p localizes to the nucleus and appears concentrated in the nucleolus.; Title: strong similarity to silencing gene hst4p -Schizosaccharomyces pombe; See PMID 10512858
An08g02510	Function: DNA polymerase epsilon p17 subunit p17 of H. sapiens functions in chromosomal DNA replication and probably DNA repair.; Similarity: the predicted ORF shows 56 amino acids long extentions at the N-terminus and at the C-terminus compaired to DNA polymerase epsilon p17 subunit p17 of H. sapiens.; Title: similarity to DNA polymerase epsilon p17 subunit p17 - Homo sapiens; See PMID 10801849
An08g02520	Remark: the ORF is a putative GTP binding protein.; Remark: the first 93 amino acids are nearly identical to E. nidulans myosin-related protein homolog MlpA.; Title: strong similarity to hypothetical protein YER006w - Saccharomyces cerevisiae
An08g02530	Catalytic activity: glycerol 3-phosphate + H2O = glycerol + phosphate.; Remark: GPP2 has a high specificity for dl-glycerol-3-phosphate, pH optima at 6. 5, and KmG3P in the range of 3-4 mM. The osmotic induction of Gpp2p is blocked in cells that are defective in the HOG-mitogen-activated protein kinase pathway, indicating that GPP2 is a target gene for this osmosensing signal transduction pathway.; Remark: also strong similarity to S. cerevisiae cytosolic glycerol-3-phosphatase encoded by GPP2 gene patent WO9928480-A1.; Title: strong similarity to hyperosmolarity-responsive protein Hor2 - Saccharomyces cerevisiae; See PMID 7500933; See PMID 8662716; See PMID 11058591
An08g02560	Title: weak similarity to hypothetical threonine dehydratase ilvA - Bacillus halodurans
An08g02570	Title: weak similarity to hypothetical transaminase DR1350 - Deinococcus radiodurans
An08g02580	Remark: during embryogenesis the expression of Hec-Otx becomes restricted to cell lineages fated to give rise to the anterior-most nervous system and the stomodeal component of the primordial pharynx. In hatched larvae Hec-Otx transcripts are detected only in the sensory (brain) vesicle. RA (all-trans retinoic acid) reduces Hec-Otx expression in the tailbud stomodeal pharynx primordium/anterior nervous system cell line but not in the larval sensory vesicle, suggesting that RA regulation of Hec-Otx expression is restricted to pharyngeal tissues throughout embryonic and postlarval development.; Similarity: to unassigned homeobox proteins.; Title: similarity to homeobox protein Hec-Otx -Herdmania curvata; See PMID 11180813
An08g02590	Function: S. cerevisiae PMU1 gene is required in addition to the MAL4 gene for both constitutive maltase synthesis and maltose utilization.; Function: overexpression of S. cerevisiae PMU1/YKL128c reduced the levels of trehalose-6-phosphate in tps2 mutants.; Remark: PMU1 has twice independently been designated in S. cerevisiae and likely describes two different genes,with only PMU1/YKL128c having been characterised on a molecular level.; Title: similarity to trehlose metabolism factor Pmu1 - Saccharomyces cerevisiae; See PMID 7050624; See PMID 8913738
An08g02600	Remark: the similarity of the predicted A. niger protein and the S. cerevisiae NPL6 protein is restricted to the N-termial half of the protein.; Title: similarity to nuclear localization protein Npl6 - Saccharomyces cerevisiae; See PMID 8514125
An08g02670	Title: strong similarity to EST an_3167 -Aspergillus niger
An08g02680	Remark: blastp matches are due to repetetive structures.
An08g02690	Title: questionable ORF
An08g02700	Catalytic activity: methionine adenosyltransferases convert ATP and L-methionine and H(2)O to phosphate and diphosphate and S-adenosyl-L-methionine.; Function: adenosylmethionine is an important methyl donor in most transmethylation reactions and is also the propylamino donor in the biosynthesis of polyamines.; Phenotype: muations of the human adenosylmethionine can result in an autosomal recessive disorder, the hypermethioninemia.; Title: strong similarity to S-adenosylmethionine synthase eth-1 - Neurospora crassa; See PMID 8849888
An08g02710	Function: overexpression of S. pombe fet5 suppresses the genetic-defect of nuclear RNA polymerases I-III.; Remark: the predicted A. niger protein contains a leucine zipper region (aa 75-97).; Title: strong similarity to transcription factor fet5p - Schizosaccharomyces pombe; See PMID 9190794
An08g02730	Localization: the A. proteus myosin is found throughout the amoeba cytoplasm but is more concentrated in the ectoplasmic regions.; Similarity: the A. proteus myosin appeares to exist in three different isoforms, with closely related amino acids in the globular head region.; Title: strong similarity to myosin heavy chain -Amoeba proteus; cytoplasm; See PMID 9864850
An08g02740	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An08g02750	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An08g02760	Similarity: the only similarities of the predicted A. niger are due to a N-terminal fungal Zn(2)-Cys(6) binuclear cluster (aa 6-44).; Title: weak similarity to zinc binuclear cluster protein sequence #30 from patent WO200224865-A2 -Unclassified organism
An08g02770	Complex: S. cerevisiae VMA13 is part of V-ATPase, a multisubunit complex composed of at least eight subunits.; Function: S. cerevisiae VMA13 s essential for activity, but not assembly, of V-ATPase.; Remark: alternative names for S. cerevisiae VMA13 are CLS11 and YPR036W.; Title: strong similarity to vacuolar H(+)-ATPase activator subunit Vma13 - Saccharomyces cerevisiae; vacuole; See PMID 8349704
An08g02780	Remark: the H. sapiens TMF (TATA element modulatory factor) protein binds to the human TATABox in a human immunodeficiency virus 1 TATA element gel-retardation assay.; Similarity: the H. sapiens TMF contains leucine-zipper amino acid motifs (aa 468-486, 471-493,478-500).; Title: strong similarity to transcription factor TMF - Homo sapiens; nucleus; See PMID 1409643
An08g02790	Remark: the systematic name for S. cerevisiae NAS6 is YGR232W.; Similarity: S. cerevisiae Nas6p shows similarity to a subunit of the 19S proteasome regulatory particle.; Title: strong similarity to hypothetical 19S proteasome interacting protein Nas6 - Saccharomyces cerevisiae; See PMID 9714768; See PMID 10873636; See PMID 11029046
An08g02800	Function: A. thaliana PRL1 encodes a regulatory WD protein that interacts with ATHKAP2, an alpha-importin nuclear import receptor, and is imported into the nucleus.; Remark: the predicted A. niger protein contains 6 G-beta repeats (PF00400).; Title: strong similarity to nuclear WD protein PRL1 - Arabidopsis thaliana; nucleus; See PMID 9765207
An08g02810	Complex: the active complex consits of six subunits.; Function: the S. pombe Orc1 protein is component of the origin recognition complex (ORC) that binds origins of replication. It has a role both in chromosomal replication and in mating type transcriptional silencing.; Similarity: the S. pombe Orc1 protein belongs to the ORC1/CDC6/CDC18 family.; Title: strong similarity to origin recognition protein orc1p - Schizosaccharomyces pombe; nucleus; See PMID 7502077
An08g02830	Remark: the H. sapiens MM1 was isolated out of a yeast two hybrid screen of human Hela cell cDNA. .; Title: strong similarity to c-myc associated protein MM1 - Homo sapiens; nucleus; See PMID 9792694
An08g02850	Remark: the mutT proteins play an important role in preventing incorporation of mutagenic nucleotides into DNA by hydrolyzing 8-oxo-dGTP.; Title: similarity to hypothetical protein MUTT -Arabidopsis thaliana
An08g02860	Similarity: E. coli proS belongs to the class II tRNA synthetase family.; Title: strong similarity to cytoplasmic proline--tRNA ligase proS - Escherichia coli; cytoplasm; Catalytic activity: prolyl-tRNA synthetases convert ATP and L-proline and tRNA(Pro) to AMP and diphosphate and L-prolyl-tRNA(Pro).; See PMID 2203971
An08g02870	Function: H. sapiens CCAAT-binding factor (CBF) regulates the expression of the human heat shock gene hsp70.; Title: strong similarity to CCAAT-binding transcription factor CBF - Homo sapiens; See PMID 2247079
An08g02900	Function: the N. crassa mtr gene product is required for the uptake of neutral aliphatic and aromatic amino acids, as well as toxic analogs such as p-flurophenylalanine or 4-methyltryptophan.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794
An08g02910	Title: strong similarity to hypothetical conserved protein 17E5.150 - Neurospora crassa
An08g02920	Catalytic activity: P450 enzymes catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: G. fujikuroi P450I is involved in gibberellin biosynthesis.; Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains in a multitude of biochemical pathways.; Remark: the annotated A. niger protein contains two cytochrom p 450 consensus sequences and displays strong similarity to a broad range of cytochrome P450 enzymes.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370
An08g02930	Title: strong similarity to nucleoporin NUP107 -Rattus norvegicus; nucleus; See PMID 8021268
An08g02940	Title: strong similarity to EST an_3396 -Aspergillus niger
An08g02950	Function: S. cerevisiae SMT3 can be conjugated to a number of proteins by ubiquitin ligase E1 and E2 like enzymes.; Remark: the systematic name for SMT3 of S. cerevisiae is YDR510W.; Similarity: S. cerevisiae SMT3 belongs to the SUMO class of ubiquitin like proteins.; Title: strong similarity to ubiquitin like protein Smt3 - Saccharomyces cerevisiae; See PMID 9312010; See PMID 10759568
An08g02960	Title: weak similarity to protein SEQ ID NO:7168 from patent WO200253728-A2 - Candida albicans
An08g02970	Catalytic activity: S. cerevisiae succinat-CoA ligase catalyze the stepwise synthesis of succinyl-CoA from succinate, CoA, and ATP in the presence of magnesium ion,involving phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates.; Complex: S. cerevisiae succinat-CoA ligase is an alpha-beta dimer.; Remark: S. cerevisiae succinyl-CoA ligase was shown to utilize ATP but not GTP for succinyl-CoA synthesis.; Title: strong similarity to succinat-CoA ligase alpha chain Lsc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9874242
An08g02980	Catalytic activity: succinat-CoA ligases converts GTP and succinate and CoA to GDP and succinyl-CoA and phosphate.; Complex: T. vaginalis succinat-CoA ligase is a dimer composed of an alpha and a beta subunit.; Function: the T. vaginalis beta-SCS is involved in fermentative carbohydrate metabolism.; Remark: T. vaginalis succinat-CoA ligase is found in hydrogenosomes, organelles found exclusively in certain anaerobic eukaryotes that lack mitochondria.; Title: strong similarity to succinate-CoA ligase beta chain beta-SCS - Trichomonas vaginalis; See PMID 1400232
An08g02990	Pathway: S. cerevisiae MET14 is a component of the purine metabolism, the selenoamino acid metabolism and the Sulfur metabolism.; Remark: S. cerevisiae MET14 converts ATP and adenylylsulfate to ADP and 3'-phosphoadenylylsulfate.; Similarity: S. pombe orthologue of the S. cerevisiae MET14 is SPAC1782.; Title: strong similarity to adenylylsulfate kinase Met14 - Saccharomyces cerevisiae; See PMID 1654509
An08g03000	Complex: the S. cerevisiae VMA5 is part of the multisubunit complex of the vacuolar H+-transporting ATPase.; Localization: S. cerevisiae VMA5 is located in the vacuole of the fungal cell.; Pathway: the S. cerevisiae H+-transporting ATPase chain C is part of the oxidative phosphorylation.; Remark: alternative names for S. cerevisiae VMA5 are CSL5, VAT3 and YKL080W.; Remark: the H+-transporting ATPase from S. cerevisiae belongs to a group of enzymes from the plasma membranes of yeast and Neurospora, which are closely related to the H+/K+-transporting ATPases (EC 3. 6. 1. 36).; Title: strong similarity to H+-transporting ATPase chain C Vma5 - Saccharomyces cerevisiae; See PMID 1730668
An08g03010	Title: strong similarity to EST SEQ ID NO:4179 from patent WO200056762-A2 - Aspergillus niger
An08g03020	Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF
An08g03030	Title: similarity to hypothetical protein AF1265 -Archaeoglobus fulgidus
An08g03040	Title: strong similarity to hypothetical protein CAA21103.1 - Schizosaccharomyces pombe
An08g03060	Title: strong similarity to hypothetical protein CC0533 - Caulobacter crescentus
An08g03070	Catalytic activity: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein <=> (6R)-5,10-methylenetetrahydrofolate + NH(3) + dihydrolipoylprotein.; Complex: the T proteins are subunits of the glycine decarboxylase multienzyme complex, which is composed of the four proteins P, T, L, and H.; Function: the S. cerevisea homolog is the T-protein of the glycin cleavage system, which enables growth on glycine as carbon source.; Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID NO:5306 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to glycine decarboxylase subunit T Gcv1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9047339
An08g03080	Title: strong similarity to hypothetical protein encoded by An08g03120 - Aspergillus niger
An08g03090	Function: the S. cerevisiae homolog Pmc1p is a calcium-transporting ATPase that pumps Ca2+ into the vacuole. Pmc1p participates in the control of the cytosolic free calcium homeostasis.; Remark: the cellular response to changes in the environmental levels of Ca2+ is mediated by calmodulin and calcineurin which, in turn, modulate the various types of Ca2+ transporters.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae; vacuole
An08g03120	Title: similarity to hypothetical serine/threonine-specific protein kinase SPAC3C7.06c -Schizosaccharomyces pombe
An08g03150	Function: the S. cerevisiae homolog Fcy2p is a purine/cytosine permease located in the plasma membrane.; Title: strong similarity to hypothetical purine-cytosine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane
An08g03170	Remark: the N. crassa homolog B9I2. 20 is significantly shorter.; Title: similarity to hypothetical protein B9I2.20 -Neurospora crassa
An08g03180	Remark: S. pombe homolog SPBC1289. 02c is hypothetical splicing factor by similarity.; Title: strong similarity to hypothetical splicing factor SPBC1289.02c - Schizosaccharomyces pombe
An08g03190	Complex: tubulin is the major constituent of microtubules. tubulin is a dimer, which consists of an alpha- and beta-chain.; Function: the A. flavus homolog beta-tubulin is the beta-subunit of tubulin, which is a structural protein of the cytoskeleton and is involved in chromosome segregation and nuclear migration.; Title: strong similarity to tubulin beta chain beta-tubulin - Aspergillus flavus; cytoskeleton
An08g03200	Function: the S. cerevisiae homolog Mep2p is a low capacity, high affinity ammonium permease. Mep2p is involved in pseudohyphae formation in response to nitrogen starvation.; Title: strong similarity to ammonium transport protein Mep2 - Saccharomyces cerevisiae
An08g03240	Pathway: Wak1 of S. pombe participates in the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway.; Regulation: Wak1 of S. pombe is regulated by Mcs4.; Remark: cells lacking Mcs4 or Wak1, however, are able to proliferate under stressful conditions and undergo sexual differentiation, suggesting that additional pathway(s) control the Wis1 MAPKK.; Similarity: the predicted A. niger protein shows strong similarity to the MAP kinase kinase kinase Wak1 of S. pombe and related kinases.; Title: strong similarity to MAP kinase kinase kinase wak1p - Schizosaccharomyces pombe
An08g03250	Title: strong similarity to hypothetical protein BAB27989.1 - Mus musculus
An08g03260	Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:4450 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical mago nashi-like protein - Oryza sativa
An08g03270	Function: the S. cerevisiae homolog Sec26p is the beta chain subunit (beta-COP) of the COPI coatomer complex,which is required for budding from golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.; Title: strong similarity to beta-COP Sec26 -Saccharomyces cerevisiae; intracellular transport vesicles
An08g03280	Function: S. cerevisiae Lcb4p is a sphingoid long chain base (LCB) kinase involved in sphingolipid biosynthesis. Lcb4p can use phytosphingosine,dihydrosphingosine, or sphingosine as substrate.; Remark: the alternative gene name for the S. cerevisiae homolog LCB4 is YOR171c.; Title: strong similarity to sphingoid long chain base kinases Lcb4 - Saccharomyces cerevisiae
An08g03290	Similarity: the ORF shows strong similarity to expressed sequence tag an_3108 from Aspergillus niger.; Title: similarity to hypothetical protein SPAC9B6.07 - Schizosaccharomyces pombe
An08g03300	Function: the S. cerevisiae homolog gene PDR5 encodes a membrane protein of the ATP-binding-cassette (ABC) superfamily, which is functioning as a drug extrusion pump with multiple pleiotropic substrates.; Induction: expression of S. cerevisiae Pdr5p is regulated by the pleiotropic drug resistance (PDR) network. Transcriptional regulator are Pdr1p, Pdr3p, Pdr7p, and Pdr9p, which also control transcription of several other target genes, many of them also ABC transporter proteins like SNQ2, STE6, PDR10, PDR11 and YOR1.; Title: strong similarity to multidrug resistance protein Pdr5p from patent WO200052144-A1 - Saccharomyces cerevisiae; plasma membrane
An08g03320	Title: similarity to hypothetical protein SPAPB2B4.07 - Schizosaccharomyces pombe
An08g03340	Remark: H. sapiens homolog AAH06108. 1 is significantly longer.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein AAH06108.1 - Homo sapiens
An08g03360	Function: S. pombe kin1 affects composition or organization of the cell wall, altering the cell shape when deleted.; Similarity: the S. pombe homolog kin1 is closely related to the KIN1- and KIN2-encoded serine/threonine-specific protein kinases of S. cerevisiae.; Title: strong similarity to protein kinase kin1p -Schizosaccharomyces pombe
An08g03380	Catalytic activity: S-adenosyl-L-methionine + histone L-lysine <=> S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.; Function: the S. pombe homolog Clr4 is a histone H3-specific methyltransferase, known to regulate silencing and switching at the mating-type loci due to remodeling of the chromatin structure. Clr4 methylates preferentially lysine 9 of histone H3 (H3 Lys9).; Title: strong similarity to hypothetical mating-type loci and centromere silencing protein clr4p -Schizosaccharomyces pombe
An08g03390	Similarity: the similarity is restricted to the N-terminal region of the A. niger protein.; Title: weak similarity to DNA-directed RNA polymerase II largest chain RBP1 - Nosema locustae
An08g03400	Function: the S. cerevisiae homolog Cch1p is involved in calcium influx and the late stage of the mating process.; Title: strong similarity to calcium channel protein Cch1 - Saccharomyces cerevisiae
An08g03420	Similarity: the ORF shows similarity to expressed sequence tag h1c04a1. f1 from Aspergillus nidulans.; Title: similarity to hypothetical protein CG13349 -Drosophila melanogaster
An08g03430	Remark: L6 of S. cerevisiae belongs to the L6E family of ribosomal proteins.; Remark: L6 of S. cerevisiae is also called L9324. 4,YLR448w, or YL16. B.; Similarity: the ORF shows also strong similarity to EST seq id NO:4762 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L6 - Saccharomyces cerevisiae; cytoplasm; See PMID 1390890
An08g03440	Title: similarity to hypothetical protein F49E12.10 - Caenorhabditis elegans
An08g03450	Function: the S. cerevisiae homolog Tsc10p is necessary and sufficient for catalyzing the NADPH-dependent reduction of 3-ketosphinganine to dihydrosphingosine.; Pathway: S. cerevisiae Tsc10p catalyzes the second step in the synthesis of phytosphingosine.; Remark: an alternative gene name for S. cerevisiae TSC10 is YBR265w.; Title: strong similarity to 3-ketosphinganine reductase Tsc10 - Saccharomyces cerevisiae
An08g03460	Function: S. cerevisiae Sas10p ('Something About Silencing') is able to disrupt silencing and derepresses genes associated with silenced chromatin when overproduced.; Localization: Sas10p is a nuclear protein.; Remark: an alternative gene name for the S. cerevisiae homolog SAS10 is YDL153c.; Title: strong similarity to protein involved in silencing Sas10 - Saccharomyces cerevisiae; nucleus
An08g03470	Function: the M. musculus homolog Msh5 shows a meiotic defect, leading to male and female sterility in mice.; Similarity: M. musculus Msh5 is a member of the mammalian mismatch repair protein family of MutS and MutL.; Title: strong similarity to DNA mismatch repair gene MSH5 from patent WO9901550-A1 - Mus musculus; nucleus
An08g03480	Localization: hsp78 from S. cereviesiae is a soluble protein located in the mitochondrial matrix.; Similarity: Hsp78p from S. cereviesiae belongs to the Clp family of ATP-dependent proteases.; Title: strong similarity to mitochondrial heat shock protein Hsp78 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8413229
An08g03490	Function: beta subunit of eukaryotic elongation factor 1 (EF-1) catalyzes the GDP/GTP exchange activity on EF-1 alpha.; Remark: EF-1 from O. cuniculus is C-terminal 100 aa shorter.; Title: similarity to elongation factor 1 beta EF-1 -Oryctolagus cuniculus; cytoplasm; See PMID 8547318
An08g03510	Function: repetitive peptides of the sequence APSASSSSA(P/S)SSSSS(+/-S) are the targets of phosphoglycosylation in L. major.; Similarity: similarity due to N-terminal serine repeats.; Title: weak similarity to proteophosphoglycan ppg1 -Leishmania major; See PMID 10531342
An08g03520	Complex: ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3 form a complex with the target protein.; Function: E2 enzymes form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme (E1)-dependent manner,and specifically select target proteins for degradation by the proteasome.; Similarity: shows similarity only in N-terminal half and is C-terminal 200 aa longer than human UBE2.; Title: similarity to ubiquitin conjugating enzyme UBE2 - Homo sapiens [putative frameshift]; cytoplasm; putative frameshift; See PMID 1379239; See PMID 11117256
An08g03530	Function: suppression of the thermosensitive phenotype of U5 snRNA (U5AI) identifies SSD1 from S. cerevisiae as a general suppressor of splicing mutants.; Similarity: SSD1 from S. cerevisiae is related to the HSP70 superfamily.; Title: strong similarity to protein phosphatase homolog CaSSD1 - Candida albicans; See PMID 9846729; See PMID 10446233
An08g03550	Title: similarity to hypothetical RNA export mediator like protein CAD21423.1 - Neurospora crassa
An08g03560	Similarity: similarity due to serin and threonine repeats confined to central region.; Title: weak similarity to mucin MUC2 - Rattus norvegicus
An08g03570	Similarity: only C-terminal half shows similarity to C-terminal half of MyHC3 C. coturnix.; Title: similarity to slow myosin heavy chain MyHC3 -Coturnix Coturnix; cytoskeleton; See PMID 8663323
An08g03580	Function: BGT1 from A. fumigatus introduces intrachain 1,6-beta linkages into 1,3-beta-glucan.; Title: strong similarity to 1,3-beta-glucanosyltransferase bgt1 - Aspergillus fumigatus; cell wall; See PMID 9846753
An08g03590	Function: Emp24p from S. cerevisiae is a type I transmembrane protein that is involved in secretory protein transport from the endoplasmic reticulum (ER) to the Golgi complex.; Localization: Emp24p from S. cerevisiae is a component of ER-derived COPII-coated vesicles.; Title: strong similarity to precursor of protein Emp24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 7729411
An08g03600	Title: similarity to hypothetical protein CAE47874.1/AfA24A6.130c - Aspergillus fumigatus
An08g03610	Function: lysosomal phosphodiesterase that hydrolyzes sphingomyelin to ceramide and phosphocholine.; Similarity: human ASM1 is C-terminally 200 aa shorter.; Title: similarity to acid sphingomyelinase phosphodiesterase ASM1 - Homo sapiens; See PMID 2555181
An08g03620	Function: BMH2 from S. cerevisiae is essential for pseudohyphal-development MAPK cascade signaling.; Similarity: only C-terminal 100 aa show similarity to BMH2 from S. cerevisiae.; Title: weak similarity to 14-3-3 protein Bmh2 -Saccharomyces cerevisiae; See PMID 9215628
An08g03630	Similarity: only C-terminal half shows weak similarity to N-terminal part of much longer VRP1 from S. cerevisiae.; Title: weak similarity to verprolin Vrp1 -Saccharomyces cerevisiae
An08g03640	Function: TOXA of C. carbonum exports the cyclic tetrapeptide HC-toxin, which is responsible for the maize pathogenicity of the fungus.; Function: TOXA of C. carbonum may function in self-protection against the HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase.; Similarity: TOXA from C. carbonum belongs to the major facilitator superfamily.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997
An08g03650	Function: PUT3 from S. cererevisiae is a positive activator of the proline utilisation pathway.; Remark: similarity is confined to cental 100 aa.; Title: weak similarity to transcription activator Put3 - Saccharomyces cerevisiae
An08g03660	Remark: melusin M. musculus can be regulated by intracellular signals affecting Ca(2+) concentration.; Title: strong similarity to muscle-specific interactor for beta(1) integrin melusin - Mus musculus; See PMID 10506186
An08g03670	Catalytic activity: ATP + ethanolamine <=> ADP + O-phosphoethanolamine; Function: human ethanolamine kinase catalyzes the initial step in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis.; Title: strong similarity to ethanolamine kinase EKI1 - Homo sapiens; See PMID 9421192
An08g03680	Title: similarity to hypothetical protein CAE47897.1/AfA28D10.030 - Aspergillus fumigatus
An08g03690	Function: ARF-GDP causes COPI dissociation and stimulates the formation of retrograde transport structures that recycle Golgi membrane back to the ER.; Function: human and S. cerevisiae ARF1-GTP, through assembly of COPI to membranes and, possibly, through activation of PLD, is likely to promote the formation and maturation of pre-Golgi intermediates into Golgi elements.; Localization: the cytoplasmic human protein complex ARF1/COPI undergoes regulated assembly and disassembly with membranes of ER and Golgi.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to ADP-ribosylation factor arf1 - Ajellomyces capsulatus; cytoplasm; See PMID 9681627
An08g03700	Title: strong similarity to hypothetical protein CAE47899.1/AfA28D10.040c - Aspergillus fumigatus
An08g03710	Title: strong similarity to hypothetical protein CAD36993.1 - Neurospora crassa
An08g03720	Title: similarity to fungal ZBC protein sequence #44 from patent WO200224865-A2 - unidentified organism
An08g03730	Catalytic activity: Gibberellin + 2-oxoglutarate + O(2) <=> 2-beta-hydroxygibberellin + succinate + CO(2).; Remark: closest manual homolog (BLASTP) is PIR:T09683 gibberellin 7-oxidase - Cucurbita maxima (winter squash).; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256
An08g03740	Catalytic activity: Acyl-[acyl-carrier protein] + NADP(+) <=> trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.; Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC from A. terreus is an accessory protein that modulates polyketide synthase activity during lovastatin biosynthesis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An08g03750	Function: FLU1 from C. albicans confers resistance to fluconazole.; Similarity: FLU1 from C. albicans belongs to the Major Facilitator Superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane
An08g03760	Title: similarity to hypothetical protein Rv3472 -Mycobacterium tuberculosis
An08g03770	Function: MUC-type mucins comprise a family of structurally related molecules, which are expressed in epithelia of the body that are in close contact with the milieu.; Title: weak similarity to mucin MUC5AC - Homo sapiens; See PMID 7826332; See PMID 9866714
An08g03780	Function: it is suggested that Tri11 from F. sporotrichioides encodes a C-15 hydroxylase involved in trichothecene biosynthesis.; Phenotype: disruption of TRI11 of F. sporotrichioides results in accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: TRI11 of F. sporotrichioides defines a new cytochrome P-450 gene family, designated CYP65A1.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078
An08g03790	Function: like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.; Function: many polyketides are antibiotics.; Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Function: whereas the intermediates in fatty acid biosynthesis are fully reduced to generate unfunctionalized alkyl chains, the intermediates in polyketide biosynthesis may be only partially processed, giving rise to complex patterns of functional groups.; Remark: polyketide synthases are commercially valuable enzyme.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10872449
An08g03800	Remark: n-terminal truncated ORF due the end of contig.; Similarity: Protein is also similar to probable component of a peptide synthetase hetM protein - Anabaena sp. (strain PCC 7120); Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus [truncated ORF]; See PMID 8157596; See PMID 8936303
An08g03810	Similarity: shows strong similarity to C-terminal two-thirds of An02g00870.; Title: similarity to hypothetical protein encoded by An02g00870 - Aspergillus niger
An08g03820	Similarity: Product is also similar (E-val. 9e-95) to toxD of Cochliobolus carbonum, its role in synthesis of peptide antibiotics is still not yet clear.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994
An08g03830	Catalytic activity: cinnamyl alcohol + NADP(+) <=> cinnamaldehyde + NADPH-.; Pathway: lignin biosynthesis.; Remark: Eucalyptus gunnii=cider tree.; Remark: catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508
An08g03840	Remark: The qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580; See PMID 1825499
An08g03850	Remark: QutD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 3049934; See PMID 2835177; See PMID 2976880
An08g03870	Remark: QUTA is a positively acting regulatory protein that regulates the expression of the eight genes comprising the quinic acid utilization gene (qut) gene cluster in Aspergillus nidulans. Genetic evidence suggests that the activity of the native QUTA transcription activator protein is negated by the action of the QUTR transcription repressor protein. It has been proposed that the QUTA protein is composed of two domains that are related to the N-terminal two domains-dehydroquinate (DHQ) synthase and 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase-of the pentadomain AROM protein.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987
An08g03880	Function: Mutant phenotypes imply that the QutR protein plays a key role in signal recognition and transduction.; Function: Mutations in the qutR gene alter QutR function such that the transcription of the qut gene cluster is permanently on (constitutive phenotype) or is insensitive to the presence of quinate (super-repressed phenotype).; Remark: QutR-encoded transcription-repressing protein is a multi-domain repressor protein active in the signal-transduction pathway that regulates transcription of the quinic acid utilization (qut) gene cluster in Aspergillus nidulans.; Title: strong similarity to hypothetical negative-acting regulatory protein qutR - Aspergillus nidulans; See PMID 8704987; See PMID 10926843; See PMID 1544567
An08g03890	Catalytic activity: the superoxid Cu/Zn dismutase converts 2 peroxide radical and 2 H(+) to O(2) and H(2)O(2).; Remark: alternate names for the superoxid Cu/Zn dismutase is erythrocuprein, hemocuprein or cytocuprein.; Remark: superoxid Cu/Zn dismutase from most eucaryotes contain both copper and zinc; those from mitochondria and most procaryotes contain manganese or iron.; Title: strong similarity to hypothetical superoxid Cu/Zn dismutase B24P7.320 - Neurospora crassa
An08g03900	Catalytic activity: the C. porcellus FMO2 converts N, N-dimethylaniline and NADPH and O(2) to N,N-dimethylaniline N-oxide and NADP(+) and H(2)O.; Function: FMO2 belongs to the oxidoreductases of the lung microsomes, who need FAD as a cofactor.; Remark: a mutation in the FMO2 gene causes the human inheritable disorder trimethylaminuria.; Title: similarity to dimethylanilin monooxygenase FMO2 - Cavia porcellus; See PMID 1306120
An08g03910	Remark: the R. norvegicus L10a protein is a subunit of the 60S ribosomal complex.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L10a - Rattus norvegicus; cytoplasm; See PMID 8607874
An08g03920	Title: strong similarity to hypothetical protein CAE47894.1 - Aspergillus fumigatus
An08g03930	Remark: the encoded protein shows similarities to Vpr1 from S. cerevisiae only at the very N- and C-terminal sequences.; Title: weak similarity to verprolin Vrp1 -Saccharomyces cerevisiae; See PMID 7968536
An08g03940	Title: similarity to hypothetical splicing factor -Schizosaccharomyces pombe
An08g03950	Title: strong similarity to hypothetical protein CAE47900.1/AfA28D10.050 - Aspergillus fumigatus
An08g03960	Title: strong similarity to hypothetical edoplasmic reticulum associated protein - Schizosaccharomyces pombe; See PMID 9414319
An08g03970	Title: strong similarity to hypothetical protein CAE47902.1 - Aspergillus fumigatus
An08g03980	Complex: the C. fasciculata IUNH forms a homotetramer.; Function: the C. fasciculata IUNH catalyses the hydrolysis of all of the commonly occuring purine and pyrimindine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates.; Remark: the IUNH is important for parasitic protozoans, which are deficient in de novo synthsis of purines, to salvage the host purine nucleosides.; Title: strong similarity to inosine-uridine nucleosid hydrolase IUNH - Crithidia fasciculata; See PMID 8634237
An08g04000	Title: strong similarity to hypothetical transcription factor CAE47904.1 - Aspergillus fumigatus
An08g04030	Function: the E. coli Hbp interacts with hemoglobin,degrades it and subsequently binds the released heme.; Remark: pathogenic E. coli strains are capable of using hemoglobin as an iron source.; Remark: the similarity of the predicted A. niger protein to the Hbp protein is restricted to the N-terminal part of the A. niger protein (aa 7-280).; Similarity: the E. coli Hbp belongs to the so-called IgA1 protease-like proteins, as indicated by the kinetics of its membrane transfer and DNA sequence similarity.; Title: weak similarity to hemoglobin protease Hbp -Escherichia coli; See PMID 9743528
An08g04040	Function: qutD of A. nidulans is required for the transport of quinate into the mycelium.; Similarity: qutD of A. nidulans belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880
An08g04050	Title: similarity to hypothetical protein CAE47908.1/AfA28D10.093c - Aspergillus fumigatus
An08g04060	Title: strong similarity to hypothetical transcription factor IIIc-like protein CAE47909.1 -Aspergillus fumigatus
An08g04070	Complex: the MOM22 protein is part of receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins.; Function: the receptor complex in the mitochondrial outer membrane is responsible for the recognition and translocation of cytosolically synthesized preproteins.; Title: strong similarity to mitochondrial receptor complex chain MOM22 - Neurospora crassa; localisation:mitochondrion; See PMID 8348615
An08g04080	Function: MPP of N. crassa is a mitochondrial processing peptidase, which releases the N-terminal transit peptides from precursor proteins imported into the mitochondrion.; Remark: E. C. number has been changed from 3. 4. 99. 41 to 3. 4. 24. 64.; Title: strong similarity to mitochondrial processing peptidase alpha chain MPP - Neurospora crassa; localisation:mitochondrion; See PMID 2141023
An08g04090	Catalytic activity: acsA of S. meliloti catalyzes the reaction of ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.; Function: acsA of S. meliloti activates acetoacetate to acetoacetyl-CoA.; Function: acsA of S. meliloti is involved in poly-3-hydroxybutyrate degradation.; Similarity: acsA of S. meliloti belongs to the ATP-dependent AMP-binding enzyme family.; Title: strong similarity to acetoacetyl-CoA synthase acsA - Sinorhizobium meliloti; See PMID 10735852
An08g04100	Catalytic activity: LCB2 of S. cerevisiae catalyzes the reaction of palmitoyl-CoA + l-serine = CoA + 3-dehydro-d-sphinganine + CO(2).; Complex: LBC1 and LBC2 may encode subunits of the enzyme.; Pathway: LCB2 of S. cerevisiae catalyzes the first step in the biosynthesis of the long-chain base component of sphingolipids.; Remark: SCS1, YDR062W, YD9609. 16 and D4246 are alternative names for LCB2.; Remark: a splice site was detected upstream of the START codon.; Similarity: LCB2 of S. cerevisiae belongs to class-II of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to serine palmitoyltransferase 2 Lcb2 - Saccharomyces cerevisiae; See PMID 8058731
An08g04110	Title: similarity to hypothetical membrane protein YDR352w - Saccharomyces cerevisiae
An08g04120	Similarity: the ORF also shows strong similarity to the 5' end of the cDNA clone 2094 of A. niger.; Title: similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus
An08g04130	Title: similarity to hypothetical protein SPBC1706.01 - Schizosaccharomyces pombe
An08g04140	Function: par1 of C. elegans is required for the first asymmetric cleavage in embryogenesis.; Remark: the similarity of the ORF encoded protein to par1 is restricted to the kinase domain.; Similarity: the ORF encoded protein also shows similarity to other kinases.; Title: similarity to serine/threonine kinase par-1 -Caenorhabditis elegans; See PMID 7758115
An08g04150	Remark: YNL284C is the systematic name for MRPL10 of S. cerevisiae.; Similarity: MRPL10 of S. cerevisiae shows similarity to bacterial ribosomal L15 proteins.; Title: similarity to mitochondrial ribosomal protein of the large subunit L15 Mrpl10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626
An08g04160	Title: similarity to hypothetical CLG1 cyclin clg1 -Ajellomyces capsulatus
An08g04180	Remark: the ORF encoded protein is N-terminally truncated due to the contig border.
An08g04190	Remark: the ORF encoded protein is C-terminally truncated due to the contig border.
An08g04240	Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol; Function: NDH2 of Y. lipolytica is the alternative protein for respiratory chain complex I, that does not translocate protons across the inner mitochondrial membrane.; Remark: the alternative NADH:ubiquinone reductase of Y. lipolytica is in contrast to the proteins of S. cerevisiae, Neurospora crassa and green plants probably not binding NADH synthesized in the mitochondrial matrix, but from external origin, as known for common complex I proteins.; Title: strong similarity to alternative NADH:ubiquinone reductase NDH2 - Yarrowia lipolytica; See PMID 10381390
An08g04250	Title: strong similarity to dynamin-related protein msp1p - Schizosaccharomyces pombe; See PMID 9790976; See PMID 10547374
An08g04260	Title: similarity to hypothetical protein YNL191w -Saccharomyces cerevisiae
An08g04270	Title: strong similarity to hypothetical protein CAD70845.1 - Neurospora crassa
An08g04280	Remark: also similarity to oligouridylate binding protein ubp1; Nicotiana plumbaginifolia; Title: similarity to polyadenylated RNA-binding protein Pub1 - Saccharomyces cerevisiae; See PMID 10943833; See PMID 8413213
An08g04290	Title: strong similarity to hypothetical protein CAE47925.1 - Aspergillus fumigatus
An08g04300	Function: ROD1 of S. cerevisiae convers resistance to O-dinitrobenzene, calcium and zinc.; Title: similarity to resistance protein Rod1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8621680
An08g04310	Remark: putative N-acetyltransferase domain; Title: similarity to hypothetical protein SPAC56E4.07 - Schizosaccharomyces pombe
An08g04330	Title: similarity to hypothetical endo alpha-1,4 polygalactosaminidase - Pseudomonas sp.
An08g04350	Remark: Chs7p is involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis.; Remark: control of protein export from the ER (like chitin synthase III).; Title: similarity to chitin synthase III like Chs7 -Saccharomyces cerevisiae; See PMID 10366589
An08g04360	Title: strong similarity to hypothetical protein CAE47928.1/AfA28D1.070 - Aspergillus fumigatus
An08g04370	Remark: hACTE-III is a peroxisomal acyl-CoA thiolesterase and exhibits enzymatic specificity for a broad range of fatty acyl-CoAs.; Similarity: the human homolog hACTE-III shows similarity to E. coli thioesterase II.; Title: similarity to peroxisomal acyl-CoA thiolesterase hACTE-III - Homo sapiens; peroxisome; See PMID 9299485
An08g04380	Remark: component of the small subunit of mitochondrial ribosome.; Title: similarity to mitochondrial ribosomal protein of the small subunit Mrp17 - Saccharomyces cerevisiae; See PMID 1279374; See PMID 9445368
An08g04390	Catalytic activity: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein to (6R)-5,10-methylenetetrahydrofolate + NH(3) + dihydrolipoylprotein.; Pathway: glycine degradation.; Title: strong similarity to glycine decarboxylase subunit H Fun40 - Saccharomyces cerevisiae; See PMID 9020168
An08g04400	Remark: zinc-regulated gene suggested to function in zinc-uptake.; Title: similarity to membrane protein Zrg17 -Saccharomyces cerevisiae; See PMID 10978274
An08g04410	Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Remark: identical to Aspergillus niger EST AN05D07.; Title: strong similarity to hypothetical 14 kD subunit of NADH:ubiquinone reductase - Neurospora crassa
An08g04420	Title: similarity to hypothetical protein CAE47939.1 - Aspergillus fumigatus
An08g04430	Function: human cap-binding protein 4EHP binds specifically to capped RNA in an ATP- and divalent ion-independent manner.; Remark: control of gene expression at the translational level plays an important role in cell growth and proliferation.; Remark: several pathways transmit signals from extracellular stimuli to translation components. a key participant in this regulation of translation is eIF4E, the mRNA 5' cap-binding protein.; Similarity: the predicted A. niger protein shows strong similarity to human 4E homologous protein (4EHP),human translation initiation factor 4E and other eukaryotic eIF4E-like proteins.; Title: similarity to cap-binding protein 4EHP - Homo sapiens; See PMID 9582349; See PMID 9561852
An08g04440	Title: similarity to hypothetical protein EAA66199.1 - Aspergillus nidulans
An08g04450	Catalytic activity: GDP + H2O = GMP + Orthophosphate.; Title: similarity to hypothetical guanosine-diphosphatase - Schizosaccharomyces pombe
An08g04460	Function: IF-3 binds to the 30S ribosomal subunit in prokaryotes and shifts the equlibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.; Remark: subunit: monomer; Title: similarity to translation initiation factor IF-3 - Bacillus stearothermophilus
An08g04470	Title: strong similarity to mitochondrial elongation factor Tu - Arabidopsis thaliana; localisation:mitochondrion
An08g04480	Title: strong similarity to hypothetical protein B3E4.60 - Neurospora crassa
An08g04490	Gene-ID: EPR
An08g04500	Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695
An08g04510	Title: weak similarity to hypothetical protein encoded by An18g06360 - Aspergillus niger
An08g04520	Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae
An08g04530	Title: strong similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis
An08g04540	Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus
An08g04550	Title: strong similarity to hypothetical protein B1D1.190 - Neurospora crassa [putative frameshift]; putative frameshift
An08g04560	Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa
An08g04570	Title: strong similarity to hypothetical isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta
An08g04580	Title: strong similarity to hypothetical short-chain dehydrogenase PA1379 - Pseudomonas aeruginosa
An08g04590	Title: similarity to hypothetical scaffold protein CG6385 - Drosophila melanogaster
An08g04600	Function: the S. cerevisiae homolog Ptr2p is a peptide transporter that participates in amino acid-inducible peptide transport.; Remark: The DNA and protein sequences are already updates according to the information above. All calculations (like Blast,COGs,mw,pI,. . .) and structural predictions not !!! They will be updated in the next databases release in june 2005.; Remark: imported dipeptides lead to ubiquitin-dependent degradation of Cup9, thereby de-repressing the expression of Ptr2 and increasing the cell's capacity to import peptides in a positive feedback circuit.; Repression: S. cerevisiae Ptr2p expression is repressed by the transcription factor Cup9p.; Title: strong similarity to peptide transporter Ptr2 - Saccharomyces cerevisiae; plasma membrane
An08g04620	Title: similarity to inversin mouse invs - Mus musculus
An08g04630	Remark: similarities correspond to multiple A, T or S-repeats.
An08g04640	Title: strong similarity to hypothetical lysosomal pepstatin insensitive protease CLN2 - Canis lupus
An08g04660	Catalytic activity: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate = Pyrophosphate + Geranylgeranyl diphosphate.; Title: strong similarity to geranylgeranyl diphosphate synthase GGPS1 - Homo sapiens; See PMID 10101267
An08g04670	Title: strong similarity to hypothetical sugar transporter encoded by DRA0271 - Deinococcus radiodurans
An08g04690	Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe
An08g04700	Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe
An08g04730	Catalytic activity: Succinate + Acceptor = Fumarate + Reduced acceptor.; Title: similarity to hypothetical precursor of fumarate reductase flavocytochrome - Shewanella putrefaciens
An08g04740	Induction: priB transcript was abundant in primordia, while preprimordial mycelia and mature fruiting bodies contained lower levels of this transcript.; Remark: PRIB binds to the DNA fragment containing the upstream region of priB.; Remark: the PRIB binding site has a length of 16 bp and the consensus sequence 5' GGGGGGGACAGGANCC 3'.; Similarity: the predicted A. niger protein shows similarity to the PRIB protein of L. edodes and similarity to the GAL4 zinc binuclear cluster homology found in many transcription factors.; Title: similarity to protein PRIB - Lentinus edodes; See PMID 8112580; See PMID 9498550
An08g04750	Catalytic activity: L-proline <=> D-proline; Function: the C. sticklandii homolog encodes a proline racemase.; Title: strong similarity to hypothetical protein proline racemase prdF - Clostridium sticklandii
An08g04760	Title: similarity to hypothetical tol related protein - Neurospora crassa
An08g04770	Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: weak similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 10974123; See PMID 7557402; See PMID 9435787; See PMID 10875280
An08g04780	Remark: similarity corresponds only to a central region of H. sapiens ankyrin B protein (Ank repeats). The encoding gene ANK2 undergoes alternative splicing processes, leading to two different splice forms.; Title: similarity to ankyrin Ank2 - Homo sapiens [putative frameshift]; putative frameshift
An08g04790	Remark: similarity corresponds only to a central region of M. grisea PTH11 protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane
An08g04800	Title: weak similarity to hypothetical protein encoded by An02g12810 - Aspergillus niger
An08g04810	Catalytic activity: 2,5-Dihydro-5-oxofuran-2-acetate = cis,cis-Hexadienedioate; 4-Methylmuconolactone = 3-Methyl-cis,cis-hexadienedioate; Title: strong similarity to muconate cycloisomerase catB - Pseudomonas putida
An08g04820	Remark: sequence similarity only corresponds to C-terminal region of M. xanthus saframycin Mx1 synthetase safA.; Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus
An08g04830	Remark: no N-terminal homology to M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An08g04840	Title: strong similarity to hypothetical protein encoded by An08g04850 - Aspergillus niger
An08g04850	Title: strong similarity to hypothetical protein encoded by An08g04840 - Aspergillus niger
An08g04860	Function: YCF1 of S. cerevisiae is an ABC transporter that confers resistance to cadmium and transports bilirubin into vacuoles.; Remark: a putative sequencing error results in a premature STOP codon.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error
An08g04870	Function: het-e of P. anserina is a G protein, and GTP binding is essential in triggering the incompatibility reaction; the GTP-binding domain seems not to be conserved in the predicted protein.; Function: in P. anserina, co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Function: the het-e1 gene of P. anserina is involved in vegetative incompatibility.; Similarity: the similarity to het-e1 of P. anserina is mainly due to the WD repeats, characteristic of the P. anserina protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787
An08g04880	Title: strong similarity to hypothetical protein CAD27304.1 - Aspergillus fumigatus
An08g04890	Function: nothing can be assessed about the possible function from these data.; Similarity: the ORF shows a very weak similarity to hamster plectin, a cytoskeletal protein, which is ten fold longer than the predicted protein.; Similarity: the ORF shows also similarity to a patented human protein named FLEXHT-12, which means 'Full length molecules expressed in human tissues', claimed to have therapeutical effects against immunological and developmental disorders as well as cancer.; Similarity: the ORF shows also strong similarity to the patented A. oryzae EST SEQ ID NO:4766 (patent number WO200056762-A2).; Title: strong similarity to hypothetical protein SPBC19G7.16 - Schizosaccharomyces pombe
An08g04900	Complex: NUP57 of S. cerevisiae forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocytoplasmic transport; in vitro,Nsp1p, Nup49p and Nup57p form a 1:1:1 stoichiometric complex to which Nic96p can also bind.; Function: NUP57 of S. cerevisiae is required for protein transport in the nucleus.; Title: similarity to nuclear pore protein Nup57 -Saccharomyces cerevisiae; See PMID 7828598; See PMID 9017593; See PMID 9476893; See PMID 9725905; See PMID 9813081
An08g04910	Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Complex: the 22 kDa chain of N. crassa is a component of the mitochondrial ubiquinone reductase, also known as complex I.; Function: complex I is a flavoprotein containing iron-sulfur centres and is an essential component of the respiratory chain.; Title: strong similarity to 22 kD subunit NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2142943; See PMID 2523803; See PMID 9593837
An08g04920	Remark: endozepine (EP) is also called diazepam binding inhibitor (DBI) or acyl-coenzyme A (CoA)-binding protein (ACBP).; Remark: for a review about endozepine functions in higher organisms see OMIM record n. 125950.; Title: strong similarity to hypothetical endozepine CAD27308.1 - Aspergillus fumigatus
An08g04930	Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal amino acid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578
An08g04960	Similarity: the similarity to the patented EST is more significant than the weak BLASTP similarities, mainly produced by the high content of low-complexity regions within the predicted protein.; Title: strong similarity to hypothetical transcription factor CAD27310.1 - Aspergillus fumigatus
An08g04970	Similarity: in the predicted protein two domains,described in the jumonji family of transcription factors,are also present, further supporting the involvement in transcription.; Similarity: the predicted protein is very similar to the N-terminal part of S. cerevisiae RPH1, also known as YER169W, a transcription factor implicated in the regulation of the DNA-repair protein PHR1; RPH1 binds DNA via zinc fingers located in its C-terminal, that are not conserved in the predicted protein.; Title: similarity to regulator protein Rph1 -Saccharomyces cerevisiae; See PMID 7758946; See PMID 10523651; See PMID 10838566
An08g04990	Catalytic activity: Acetyl-CoA + Carnitine = CoA + O-Acetylcarnitine.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to carnitine acetyl transferase facC - Aspergillus nidulans; cytoplasm
An08g05010	Title: similarity to hypothetical pathogenesis-related protein CAD27313.1 - Aspergillus fumigatus
An08g05030	Title: strong similarity to hypothetical conserved protein aq_2146 - Aquifex aeolicus
An08g05050	Title: strong similarity to hypothetical WD-repeat protein CAA21197.1 - Schizosaccharomyces pombe
An08g05060	Title: strong similarity to hypothetical protein encoded by AfA14E5.29 - Aspergillus fumigatus; cytoplasm
An08g05070	Title: similarity to hypothetical protein SCIF3.09c - Streptomyces coelicolor
An08g05080	Title: strong similarity to hypothetical protein CAE47974.1 - Aspergillus fumigatus
An08g05100	Remark: veA influences the production of the extracellular signal and regulates the initiation of conidiation due to a genetic interaction with fluG in Aspergillus nidulans.; Title: strong similarity to dark repressor of conidiation velvet veA - Aspergillus nidulans; See PMID 9691036
An08g05140	Title: questionable ORF
An08g05150	Remark: alternate names = YDR004W, YD8119. 10; Remark: rad57 is involved in DNA double-strand gap repair in S. cerevisiae.; Title: strong similarity to protein Rad57 -Saccharomyces cerevisiae; nucleus; See PMID 7624345; See PMID 9933354
An08g05160	Catalytic activity: oleate delta-12 desaturase catalyzes the conversion of linoleate + AH2 + O2 = crepenynate + A + H2O.; EC:1.14.99.33; Functin: deletion of odeA in Anidulans resulted in a strain depleted of polyunsaturated fatty acids (18:2 and 18:3) but increased in oleic acid (18:1) and total percent fatty acid content; linoleic acid-derived psi factors were absent in this strain but oleic acid-derived psi factors were increased relative to wild type.; Function: The DeltaodeA A. nidulans strain was reduced in conidial production and mycelial growth; these effects were most noticeable when cultures were grown at 26 degrees C in the dark; under these environmental conditions, the Delta odeA strain was delayed in ascospore production but produced more ascospores than wild type over time.; Function: odeA of A. nidulans encodes a Delta-12 desaturase that converts oleic acid to linoleic acid.; Title: strong similarity to oleate delta-12 desaturase odeA - Aspergillus nidulans; See PMID 11352908
An08g05180	Remark: the protein is C-terminally about 1200 aminoacids shorter than the matching protein #901 from patent WO200286090-A2.; Title: strong similarity to essential protein #901 from patent WO200286090-A2 - Aspergillus fumigatus
An08g05190	Title: similarity to hypothetical protein GT334 -Homo sapiens
An08g05200	Remark: SPT23 is required for transcription of the delta9 fatty acid desaturase gene OLE1 in S. cerevisiae.; Remark: SPT23 may exert its suppression effect in S. cerevisiae through protein-protein interactions since does not present any of the motifs generally found in transcriptional regulators or dna binding proteins.; Remark: alternate name in S. cerevisiae = YKL020C.; Title: strong similarity to transcription suppressor protein Spt23 - Saccharomyces cerevisiae; nucleus; See PMID 8203154; See PMID 9927444
An08g05230	Title: strong similarity to hypothetical endoglucanase IV - Trichoderma reesei
An08g05250	Similarity: there is another blastp hit to mouse ligatin, a trafficking receptor for phosphoglycoproteins.; Title: similarity to hypothetical protein YDR117c -Saccharomyces cerevisiae
An08g05260	Remark: S. cerevisiae LAH1 binds to the precursors of polymerase III RNAs, preferentially to precursors ending in U residues.; Remark: alternate names in S. cerevisiae = LHP1,YLA1, YDL051W.; Title: similarity to RNA-binding protein Lah1 -Saccharomyces cerevisiae; See PMID 7799435; See PMID 9412461
An08g05270	Title: questionable ORF
An08g05290	Catalytic activity: UDP-N-acetyl-D-glucosamine + [(1, 4)-(N-acetyl-beta-D-glucosaminyl)](N) <=> UDP + [(1,4)-(N-acetyl-beta-D-glucosaminyl)](N+1).; Title: strong similarity to class VI chitin synthase chsD - Aspergillus fumigatus; plasma membrane; See PMID 8807804
An08g05300	Remark: alternate names in Schizosaccharomyces pombe = STI1, STIL or SPCC645. 14C; Title: strong similarity to heat shock protein Hsp70 ss1p - Schizosaccharomyces pombe; See PMID 9524252
An08g05310	Title: weak similarity to hypothetical protein encoded by An19g00360 - Aspergillus niger
An08g05320	Catalytic activity: Estradiol-17-beta + NAD(P)(+) <=> estrone + NAD(P)H; Title: strong similarity to estradiol 17beta-dehydrogenase type 2 17beta-HSD - Homo sapiens; See PMID 8099587
An08g05330	Catalytic activity: RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 9848230
An08g05340	Remark: catalyzes the cyclization of squalene into hopene, a function analogous to the action of oxidosqualene cyclases (OSCs) in eukaryotic steroid and triterpenoid biosynthesis.; Title: strong similarity to squalene hopene cyclase SHC - Alicyclobacillus acidocaldarius; See PMID 9295270; See PMID 10375539
An08g05350	Title: strong similarity to hypothetical protein encoded by An18g00300 - Aspergillus niger
An08g05360	Remark: a putative sequencing error within the fourth exon results in a frameshift.; Remark: expression of AFUMDR1 from Aspergillus flavus in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus flavus [putative frameshift]; plasma membrane; putative frameshift; See PMID 9373135
An08g05380	Function: MNN4 transfers mannosylphosphate from GDP-mannose to N-linked oligosaccharide.; Remark: only partial similarity to MNN4 of the yeast S. cerrevisiae.; Title: similarity to mannosylphosphate transferase Mnn4 - Saccharomyces cerevisiae; See PMID 355255; See PMID 9023541
An08g05390	Title: strong similarity to hypothetical zinc-metalloprotease SPCC1442.07c - Schizosaccharomyces pombe
An08g05400	Catalytic activity: Acyl-CoA + acetyl-CoA <=> CoA + 3-oxoacyl-CoA.; Remark: alternate name for acetyl-CoA C-acyltransferase = 3-oxoacyl-CoA thiolase.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome
An08g05410	Title: weak similarity to LIS1-interacting protein Nude1 - Rattus norvegicus; See PMID 11163259; See PMID 10940388
An08g05420	Title: strong similarity to hypothetical protein SPBC27.02c - Schizosaccharomyces pombe
An08g05430	Title: weak similarity to cytoplasmic ribosomal protein of the large subunit L27 rpmA - Rickettsia prowazekii
An08g05440	Remark: DBM1 in S. cerevisiae is a GTPase-activating protein (GAP) for cdc42 and/or rho1.; Remark: DBM1 in S. cerevisiae is involved in the control of pheromone-response pathway, in polarized cell growth and proper bud site selection.; Similarity: occuring blastp matches against N-chimerins are likely to be restricted to the chimerin-GTPase-activating domain.; Title: similarity to Rho-type GTPase-activating protein Dbm1 - Saccharomyces cerevisiae; See PMID 8657111
An08g05450	Function: atrDp is involved in protection against cytotoxic compounds.; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082
An08g05460	Remark: adenosine and AMP deaminase signature at aa position 111-118.
An08g05470	Function: STU1 is essential for growth in S. cerevisiae, and disruption of STU1 causes defects in spindle assembly in yeast.; Title: similarity to mitotic spindle protein Stu1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 7806575; See PMID 10816255
An08g05490	Title: similarity to hypothetical protein At2g15220 - Arabidopsis thaliana
An08g05500	Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3060376
An08g05510	Title: similarity to EST r4b11a1.f1 - Aspergillus nidulans
An08g05520	Function: PET18 (= MAK31 +MAK32) is necessary for the structural stability of L-A dsRNA-containing particles,but not of those containing L-A (+) strand RNA in yeast.; Remark: there are five families of double-stranded RNA (dsRNA) in strains of S. cerevisiae, called L-A, L-BC,M, T, and W.; Title: strong similarity to Mak32 - Saccharomyces cerevisiae; See PMID 3551911; See PMID 3916862
An08g05530	Alternative name: SRV2.; Function: protein is required for RAS-activated adenylate cyclase activity (synthesizes cAMP from ATP).; Remark: adenylyl cyclase from S. cerevisiae contains at least two subunits, a 200 kd catalytic subunit and a 70 kd subunit (cyclase-associated protein).; Title: strong similarity to adenylate cyclase-associated protein Cap1 - Saccharomyces cerevisiae; See PMID 2158860; See PMID 2184942
An08g05540	Title: similarity to hypothetical protein encoded by FLJ10980 - Homo sapiens
An08g05560	Title: strong similarity to hypothetical protein CAF31995.1 - Aspergillus fumigatus
An08g05570	Title: similarity to secretory protein Sec5 -Saccharomyces cerevisiae; See PMID 3077331; See PMID 9153755
An08g05580	Catalytic activity: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.; Remark: isocitrate dehydrogenase from S. cerevisiae is composed of two nonidentical subunits, IDH1 and IDH2.; Title: strong similarity to precursor of isocitrate dehydrogenase (NAD+) chain Idh2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1939242
An08g05590	Similarity: the ORF is shorter than the yeast protein (281 compared to 425 amino acids).; Title: weak similarity to hypothetical protein YNL136w - Saccharomyces cerevisiae
An08g05610	Catalytic activity: NADPH + nitrate = NADP(+) + nitrite + H(2)O.; Gene-ID: niaD; Remark: the protein is necessary for nitrate assimilation.; cytoplasm; See PMID 1541396; See PMID 10846218
An08g05640	Catalytic activity: 3 NAD(P)H + NITRITE = 3 NAD(P)(+) + NH(4)OH + H(2)O.; Remark: alternative splicing might occur; Remark: this protein is required for the assimilation of nitrate (denitrification).; Title: strong similarity to nitrite reductase (NADH) niiA - Aspergillus nidulans; cytoplasm
An08g05670	Remark: probably involved in extracellular nitrate uptake.; Title: strong similarity to nitrate permease crnA -Aspergillus nidulans; plasma membrane; See PMID 1986367
An08g05680	Title: strong similarity to hypothetical protein Cj0488 - Campylobacter jejuni
An08g05690	Title: strong similarity to hypothetical protein CAD28429.1 - Aspergillus fumigatus
An08g05700	Title: similarity to hypothetical protein SPCC1393.04 - Schizosaccharomyces pombe
An08g05720	Remark: C-terminus is 254 aa shorter than soluble epoxide hydrolase (SEH) from Homo sapiens.; Title: similarity to protein SEQ ID NO:1444 from patent WO200157190-A2 - Homo sapiens
An08g05730	Remark: yeast ribosomal protein L1 is required for the stability of newly synthesized 5S rRNA and the assembly of 60S ribosomal subunits.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8474444
An08g05760	Remark: overexpression of NH2-terminal deleted MHP1 results in short spindles and disturbed nuclear migration.; Title: similarity to microtubule-interacting protein 1 Mhp1 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8947554
An08g05780	Function: human ALDRP is a dimerization partner of adrenoleukodystrophy protein and other peroxisomal ABC-transporter.; Similarity: shows strong similarity to ALDRP of N. crassa and of other species.; Title: strong similarity to adrenoleukodystrophy related protein ALDRP - Homo sapiens; peroxisome; See PMID 10551832
An08g05790	Complex: homodimer in S. cerevisiae.; Function: glycogen phosphorylase catalyzes the conversion of (1,4-alpha-D-Glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate.; Title: strong similarity to glycogen phosphorylase Gph1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3537803; See PMID 8703213; See PMID 1613787
An08g05820	Complex: G proteins contain three units (alpha, beta and gamma); the guanine nucleotide binding site is located in the alpha chain.; Similarity: shows strong similarity to G protein alpha subunit ganB of Emericella nidulans.; Title: strong similarity to G protein alpha subunit mod-D - Podospora anserina; See PMID 7939899; See PMID 10463328
An08g05840	Similarity: shows very weak similarity to pseudouridylate synthase yceC of Escherichia coli.
An08g05850	Function: OSM1 of P. grisea kinase is involved in arabitol accumulation.; Function: OSM1 of P. grisea regulates cellular turgor during hyperosmotic stress and appressorium-mediated plant infection.; Title: strong similarity to osomotic sensitivity MAP kinase OSM1 - Pyricularia grisea; See PMID 10521531
An08g05860	Title: strong similarity to hypothetical protein YLR114c - Saccharomyces cerevisiae
An08g05870	Function: human cullin-1 is involved in the SCF proteolytic pathway which is involved in regulation of the cell cycle.; Title: strong similarity to cullin 1 - Homo sapiens; See PMID 10508527
An08g05890	Function: Cdc 53 of S. cerevisiae is involved in targeting phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway.; Function: Cdc53p of S. cerevisiae functions as a noncatalytic scaffold protein bridging Cdc34p to Skp/F-box proteins.; Function: Cdc53p of S. cerevisiae is involved in G1/S transition control.; Function: Cdc53p of S. cerevisiae is involved in mitotic G1/S transition, mitotic G2/M transition and in ubiquitin-dependent protein degradation.; Title: similarity to cell cycle control protein Cdc53 - Saccharomyces cerevisiae; See PMID 8943317; See PMID 9312054; See PMID 9346239
An08g05900	Title: similarity to hypothetical protein encoded by SPAC23H3.12c - Schizosaccharomyces pombe
An08g05910	Function: End3p of S. cerevisiae is required for endocytosis and cytoskeletal organization.; Remark: mutation within sagA sensitises Aspergillus nidulans to alkylating agents.; Similarity: shows similarity to End3p of S. cerevisiae.; Title: strong similarity to protein SagA -Aspergillus nidulans; See PMID 10102359; See PMID 10594004
An08g05920	Function: Sth1p of S. cerevisiae is an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of S. cerevisiae centromeres.; Similarity: shows similarity to several Snf2p/Swi2p homologs of different species.; Title: similarity to Snf2p/Swi2p homolog Sth1 -Saccharomyces cerevisiae; nucleus; See PMID 9628931; See PMID 9799253
An08g05940	Title: similarity to hypothetical protein encoded by An12g01470 - Aspergillus niger
An08g05950	Catalytic activity: dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil + H2O = 3-ureidopropionate.; Function: the Saccharomyces kluyveri dihydropyrimidinase is capable of catalysing both dihydrouracil and dihydrothymine degradation.; Pathway: regulatory checkpoint of the pyrimidine catabolic pathway.; Title: strong similarity to dihydropyrimidinase Pyd2 - Saccharomyces kluyveri; See PMID 10574455; See PMID 10656811
An08g05960	Title: strong similarity to hypothetical protein CAD28445.1 - Aspergillus fumigatus
An08g05970	Title: strong similarity to hypothetical dual specificity protein phosphatase 3 CAD28446.1 - Aspergillus fumigatus
An08g06010	Title: questionable ORF
An08g06030	Title: strong similarity to hypothetical zinc-finger transcription factor CAD28447.1 - Aspergillus fumigatus
An08g06050	Function: UPF1 of S. cerevisiae is involved in modulating both translation termination and mRNA turnover.; Function: UPF1 of S. cerevisiae is required for rapid turnover of cytoplasmic mRNA with a premature termination codon; Remark: UPF1, MOF4 and YMR080c are alternative names for NAM7 of S. cerevisiae.; Similarity: UPF1 of S. cerevisiae is a member of the superfamily group I helicases.; Title: strong similarity to prematurely terminated mRNA decay factor Nam7 - Saccharomyces cerevisiae; cytoplasm; See PMID 1314899; See PMID 1569946
An08g06060	Function: the S. cerevisiae Imp4 protein is a component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It interacts physically with the U3 snoRNP specific protein, Mpp10. It is required for the early cleavages at sites A0, A1 and A2 of the pre ribosomal RNA to yield pre 18s ribosomal RNA processing.; Remark: alternate name for S. cerevisiae Imp4: YNL075W.; Title: strong similarity to component of the U3 snoRNP Imp4 - Saccharomyces cerevisiae; nucleus; See PMID 10409734
An08g06070	Remark: all blastp matches are about 3 times longer than the A. niger protein.; Title: weak similarity to NAD+ ADP-ribosyltransferase PPOL - Homo sapiens
An08g06080	Catalytic activity: TrpC catalyzes the the glutamine amidotransferase reaction (GAT), the indole-3-glycerol phosphate synthase reaction (IGPS) and the N-(5'-phosphoribosyl) anthranilate isomerase reaction (PRAI), respectively.; Gene-ID: trpC; Pathway: Trp C is involved in the tryptophan biosynthesis.; cytoplasm; See PMID 2936650
An08g06090	Phenotype: Deltanup184 mutations confer sensitivity to growth in nutrient-rich medium (YES) that is accompanied by nuclear poly(A)+ RNA accumulation.; Phenotype: nup184 of S. pombe is synthetically lethal with the mRNA export defective rae1-167 mutation. The consequence of the synthetic lethality is a defect in mRNA export.; Title: similarity to nucleoporin nup184p -Schizosaccharomyces pombe; nucleus; See PMID 10388805
An08g06100	Catalytic activity: 4CL-1 of P. crispum catalyzes the reaction ATP + 4-coumarate + CoA <=> AMP + diphosphate + 4-coumaroyl-CoA.; Pathway: plant 4CL-1 is involved in the biosynthesis of lignin.; Remark: fungi are known to use lignin as a carbon source.; Title: similarity to 4-coumarate-CoA ligase 4CL1 -Petroselinum crispum; See PMID 3169018
An08g06120	Title: similarity to hypothetical protein EAA65426.1 - Aspergillus nidulans
An08g06130	Function: activation of fadA from A. nidulans leads to proliferation and blocks sporulation.; Title: strong similarity to GTP-binding regulatory protein alpha chain fadA - Aspergillus nidulans; See PMID 8895563; See PMID 10947863
An08g06150	Title: similarity to hypothetical conserved protein SPAC11H11.03c - Schizosaccharomyces pombe
An08g06160	Catalytic activity: Trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Function: al-3 from N. crassa is involved in carotinoid biosynthesis.; Remark: Farnesyltranstransferase is synonymous for geranylgeranyl pyrophosphate synthetase.; Title: strong similarity to geranylgeranyl pyrophosphate synthase al-3 - Neurospora crassa; See PMID 1826006; See PMID 9017926
An08g06170	Function: in S. cerevisiae Cdc15 serves both as an activator and substrate of Cdc14.; Function: inactivation of mitotic cyclin-dependent kinases (Cdks) is required for cells to exit mitosis. in S. cerevisiae, Cdk inactivation is triggered by the phosphatase Cdc14.; Regulation: the S. cerevisiae phosphatase Cdc14 is activated by a complex network of regulatory proteins that includes the protein kinase Cdc15.; Title: similarity to cell division control protein cdc14p - Schizosaccharomyces pombe; nucleus; See PMID 8334307; See PMID 10600711
An08g06180	Function: 6-HDNO of A. oxidans oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516
An08g06190	Function: it has been suggested that Pth11p is not required for appressorium morphogenesis but is involved in host surface recognition.; Function: mutations in PTH11 of M. grisea cause a defect in appressorium differentiation.; Remark: Pth11p of M. grisea is C-terminal 400 aa longer.; Title: similarity to PTH11 - Magnaporthe grisea
An08g06200	Function: human Metaxin participates in preprotein import into mitochondria.; Remark: N-terminal 200 aa show no similarity to human Metaxin.; Title: similarity to mitochondrial import protein Metaxin - Homo sapiens; localisation:mitochondrion; See PMID 11027586
An08g06210	Function: in P. anserina the transcription factor Grisea controls expression of the mitochondrial manganese superoxide dismutase (PaSOD2).; Title: similarity to transcription factor grisea -Podospora anserina; See PMID 11134328
An08g06220	Title: strong similarity to hypothetical protein SPAPJ691.03 - Schizosaccharomyces pombe
An08g06230	Remark: similarity is confined to C-terminal region.; Title: similarity to hypothetical membrane protein YJR041c - Saccharomyces cerevisiae
An08g06240	Function: the transport of uracil into the yeast S. pombe is mediated by uracil permease, a specific co-transporter encoded by the FUR4 gene.; Title: strong similarity to uracil transport protein fur4p - Schizosaccharomyces pombe; plasma membrane; See PMID 9730284; See PMID 10085225
An08g06250	Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Similarity: bphA from A. niger is a member of a new gene family of the cytochrome P450 superfamily.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 2250647; See PMID 10852481
An08g06260	Title: strong similarity to hypothetical protein AAO49461.1 - Leptosphaeria maculans
An08g06270	Catalytic activity: Adenosine + H(2)O <=> inosine + NH(3).; Title: similarity to adenosine deaminase - Mus musculus; See PMID 2410423
An08g06300	Remark: defined as questionable ORF as Introns are much larger than Exons.; Title: questionable ORF
An08g06320	Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate + H(2) <=> D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; Function: Plc1 from S. pombe is a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase.; Function: activated by all classes of cell surface receptors, Plc proteins generate the ubiquitous second messengers inositol 1,4,5-trisphosphate and diacylglycerol.; Similarity: C-terminal 200 aa longer than similar proteins.; Title: similarity to phosphoinositide-specific phospholipase C lc1p - Schizosaccharomyces pombe; See PMID 11015615; See PMID 7732727
An08g06330	Function: epsilon-COP together with other COP-subunits assembels into the coatomer, which participates in intracellular vesicle formation and membrane transport.; Title: strong similarity to epsilon-COP - Cricetulus griseus; intracellular transport vesicles; See PMID 8626666; See PMID 10449336
An08g06340	Function: chnC from Acinetobacter catalyzes conversion of caprolactone to 6-hydroxyhexanoic acid in the cyclohexanol oxidation pathway.; Title: strong similarity to acetyl-hydrolase chnC -Acinetobacter sp.; See PMID 10940013
An08g06350	Catalytic activity: D-mannose 6-phosphate <=> D-fructose 6-phosphate.; Function: a temperature-sensitive pmi40-1 mutant of S. cerevisiae is defective in glycosylation and secretion.; Remark: protein is involved in the synthesis of GDP-mannose and dolichol-phosphate mannose in mannosyl transfer reactions in the glycosylation and mannosylation pathways.; Title: strong similarity to mannose-6-phosphate isomerase Pmi40 - Saccharomyces cerevisiae; cytoplasm; See PMID 1377774
An08g06360	Similarity: An08g06360 is N-terminal 300 aa longer.; Title: similarity to hypothetical protein SPBC21D10.13 - Schizosaccharomyces pombe
An08g06370	Catalytic activity: RIB1 from P. guilliermondii catalyses the release of formate and inorganic pyrophosphate under formation of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidine 5'-phosphate from GTP.; Function: RIB1 from P. guilliermondii is involved in riboflavin (vitamin B2) biosynthesis.; Title: strong similarity to GTP-cyclohydrolase II RIB1 - Pichia guilliermondii; See PMID 3891906; See PMID 8533469
An08g06380	Title: strong similarity to putative transcription factor CAF32051.1 - Aspergillus fumigatus
An08g06390	Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + NADH.; Function: mmsB from P. aeruginosa takes part in the valine degradation pathway.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa; See PMID 1339433
An08g06400	Complex: Arp2p from S. pombe forms a complex with Arp3p and actin.; Function: in S. pombe mutant analysis led to the hypothesis that loss of Arp2p from the actin patch affects patch motility but does not severely compromise its architecture.; Function: the Arp2/3 complex is a multi-functional protein complex that nucleates and crosslinks actin filaments.; Remark: ORF C-terminally truncated due to end of contig.; Title: strong similarity to actin-related protein arp2p - Schizosaccharomyces pombe [truncated ORF]; cytoskeleton; See PMID 10611965
An08g06410	Complex: Arp2 of S. cerevisiae is subunit of the Arp2/3 protein complex which is conserved from yeast to man.; Complex: in S. cerevisiae the complex is composed of the subunits Arp2p, Arp3p, Arc15p, Arc18p, Arc19p,Arc35p.; Function: the Arp2/3p complex of S. cervevisiae is involved in the nucleation step of actin filament assembly and in the formation of endocytic vesicles.; Function: the Arp2/3p complex of S. cervevisiae is required for the motility and integrity of cortical actin patches.; Localization: the Arp2/3 complex in S. cerevisiae localizes to cortical actin patches.; Remark: ARP2 of S. cerevisiae was formerly designated ACT2, its systematic genename is YDL029W.; Remark: ORF is N-terminally truncated due to contig border.; Title: strong similarity to actin-like protein Arp2 - Saccharomyces cerevisiae [truncated ORF]; cytoskeleton; See PMID 9243513; See PMID 10377407; See PMID 11278164
An08g06420	Title: similarity to hypothetical protein SPBC405.03c - Schizosaccharomyces pombe
An08g06430	Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Similarity: shows to several members of the DAL family of transporters of S. cerevisiae.; Similarity: the Dal family proteins of S. cerevisiae are weakly similar to bacterial (hypothetical) permeases for tartrate (ttuB), 4-hydroxyphenylacetate (hpaX),phtalate (Pht1), suggesting that proteins of the Dal family correspond to permeases for carboxylic acids.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563
An08g06440	Function: aflatoxin B1-aldehyde reductases (AFAR) catalyzes the NADPH-dependent reduction of the dialdehyde to a dialcohol.; Function: oxidation of the mycotoxin aflatoxin (AF) B(1) yields the 8,9-epoxide, which nonenzymatically hydrolyzes rapidly to a dihydrodiol that in turn undergoes slow, base-catalyzed ring opening to a dialdehyde.; Remark: a splice site was detected upstream of the START codon.; Remark: the androgen-inducible aldehyde reductase aiar of rat is closely related to aflatoxin, B1 aldehyde reductase.; Similarity: shows similarity to bacterial and plant potassium channel beta subunits and to several bacterial putative dehydrogenesases and oxidoreductases.; Similarity: shows strong similarity to human and rat aflatoxin B1-aldehyde reductases.; Title: strong similarity to androgen-inducible aldehyde reductase aiar - Rattus norvegicus; See PMID 10965890; See PMID 11409944
An08g06450	Function: hydantoin racemase of A. aurescens is involved in the complete conversion of slowly racemizing 5'-monosubstituted D,L-hydantoins to L-amino acids.; Similarity: shows similarity to nitrogen-catabolite repression sensitive DCG1 of S. cerevisisae.; Title: similarity to hydantoin racemase hyuA -Arthrobacter aurescens
An08g06460	Function: cytoplasmic gamma-tubulin complexes are targeted to centrosomes or to other microtubule organizing centers (MTOCs) via a set of so called gamma-tubulin complex binding proteins (GTBPs) that probably interact with the conserved Spc97p/Spc98p protein family of gamma-tubulin complexes.; Function: microtubule assembly is initiated in vivo by gamma-tubulin complexes.; Title: strong similarity to gamma-tubulin mipA -Aspergillus nidulans; centrosome; See PMID 2194669; See PMID 10679351; See PMID 11005014
An08g06490	Title: similarity to hypothetical protein EAA65454.1 - Aspergillus nidulans
An08g06500	Similarity: shows similarity to several putative and known phosphotyrosyl phosphatase activators.; Title: strong similarity to phosphotyrosyl phosphatase activator PTPA - Homo sapiens
An08g06520	Title: strong similarity to hypothetical protein BX649606_96 - Aspergillus fumigatus
An08g06530	Title: similarity to hypothetical protein YLR063w -Saccharomyces cerevisiae
An08g06540	Function: prohibitin of S. cerevisiae and other organisms acts as a membrane-bound chaperone for the stabilization of mitochondrial proteins.; Function: prohibitin of S. cerevisiae is an antiproliferative protein involved in determination of replicative life span and ageing.; Title: strong similarity to antiproliferative protein prohibitin Phb1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8810036; See PMID 9259555; See PMID 9632789; See PMID 10197723; See PMID 10207067
An08g06550	Catalytic activity: QH2 + 2 Ferricytochrome c = Q + 2 Ferrocytochrome c.; Pathway: ubiquinol cytochrome c reductase, also called complex III, is part of the mitochondrial respiratory chain.; Remark: subunit VIII of the S. cerevisiae cytochrome bc1 complex interacts with succinate-ubiquinone reductase and might be responsible for electron transfer from succinate to ubiquinone.; Title: strong similarity to subunit VIII of ubiquinol--cytochrome c reductase - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2170131; See PMID 3036507; See PMID 8212892; See PMID 8394810; See PMID 1317009
An08g06560	Catalytic activity: S-Adenosylmethioninamine + Putrescine = 5'-Methylthioadenosine + Spermidine.; Pathway: spermidine sinthase catalyzes the third step of polyamine biosynthesis.; Title: strong similarity to spermidine synthase Spe3 - Saccharomyces cerevisiae; See PMID 6754461; See PMID 6991493; See PMID 7040829; See PMID 8961564; See PMID 9073064
An08g06570	Catalytic activity: transketolase 1 converts sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate + D-xylulose 5-phosphate.; Function: TKL1 of S. cerevisiae is required for biosynthesis of erythrose-4-phosphate which is needed for biosynthesis of aromatic amino acids.; Pathway: TKL1 of S. cerevisiae is part of the pentose phosphate pathway.; Title: strong similarity to transketolase Tkl1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8226984; See PMID 8299150; See PMID 8534086; See PMID 8910528; See PMID 9398292
An08g06580	Function: facB from A. niger complements the acuB mutant phenotype; acuB mutants lacked both acetyl-CoA synthetase and isocitrate lyase activity.; Gene-ID: facB; Remark: facB from A. niger is probably the regulatory gene for acetate induction.; Similarity: facB from A. niger was identified by cross-hybridisation of an A. nidulans facB clone.; nucleus; See PMID 9197408; See PMID 9695922; See PMID 10483720
An08g06590	Function: rbcL of S. oleracea is involved in the methylation of the alpha-amino group of the N-terminal methionine of the processed form of the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase/oxigenase (Rubisco).; Similarity: the predicted protein shows similarity to different known and putative protein N-methyltransferases of plants.; Title: similarity to ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I rbcL - Spinacia oleracea; See PMID 10593982
An08g06600	Title: strong similarity to hypothetical protein CAF32076.1 - Aspergillus fumigatus
An08g06610	Similarity: the predicted protein has the same length and a similarity > 75% with yeast hypothetical proteins.; Similarity: the predicted protein shows some structural features and a moderate similarity to hypothetical proteins annotated as GTP-binding proteins due to the similarity to E. coli ychF, whose function, anyway,was not experimentally verified.; Title: similarity to hypothetical GTP-binding protein ychF - Escherichia coli; See PMID 7828865; See PMID 9298646; See PMID 1833189
An08g06620	Title: similarity to hypothetical protein CAF32078.1 - Aspergillus fumigatus
An08g06630	Title: strong similarity to hypothetical protein CAF32079.1 - Aspergillus fumigatus
An08g06650	Complex: NHP2 of S. cerevisiae is a component of the box H/ACA small nucleolar ribonucleoprotein particles (H/ACA snoRNPs), involved in pseudouridylation of pre-rRNAs, playing a key role in the synthesis of eukaryotic ribosomes.; Function: NHP2 of S. cerevisiae is directly interacting with RNA, facilitating the assembly of H/ACA snoRNPs, their retention into the nucleolus, and hence their function.; Similarity: NHP2 of S. cerevisiae and the predicted protein show strong similarity to ribosomal protein L7a.; Similarity: the N-terminal part of the predicted protein shows no similarity to S. cerevisiae NHP2.; Title: strong similarity to nucleolar rRNA processing protein Nhp2 - Saccharomyces cerevisiae; nucleus; See PMID 2063628; See PMID 9843512; See PMID 10502409; See PMID 10690410; See PMID 11074001
An08g06660	Complex: MAD1 of S. cerevisiae forms a tight complex with another spindle checkpoint protein, MAD2, throughout the cell cycle; furthermore, MAD1 interacts with CDC20,which activates the anaphase promoting complex, in the two-hybrid system, and the presence of MAD1 is required for MAD2 and MAD3 to interact with CDC20.; Function: MAD1 of S. cerevisiae is a non-essential gene that encodes a component of the spindle checkpoint,which delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules.; Regulation: MAD1 of S. cerevisiae becomes hyperphosphorylated upon spindle depolymerization, and the essential protein kinase MSP1 appears to phosphorylate MAD1.; Title: strong similarity to spindle assembly checkpoint protein Mad1 - Saccharomyces cerevisiae; nucleus; See PMID 7593191; See PMID 7880536; See PMID 8524250; See PMID 8895658; See PMID 1651172
An08g06670	Title: similarity to hypothetical protein SPBC4C3.06 - Schizosaccharomyces pombe
An08g06680	Function: Cdk2 of R. norvegicus interacts with cyclins A, D, or E; the activity of Cdk2 is maximal during S phase and G2.; Function: Cyclin-dependent kinase 2 (Cdk2) controls the transition from the G1 to the S phase in the mammalian cell cycle.; Title: strong similarity to cyclin dependent kinase 2-alpha Cdk2-alpha - Rattus norvegicus; deleted EC_number 2.7.1.37; See PMID 7862443
An08g06690	Similarity: more than 50% of the predicted protein length is constituted by low-complexity regions, explaining all the found BLASTP alignments, that cannot be considered functionally relevant.; Title: strong similarity to hypothetical protein CAD29595.1 - Aspergillus fumigatus
An08g06700	Function: ys1 of Z. mays is a membrane protein involved in iron uptake, mediating the import of the (Fe3+)-phytosiderophore complex at the root surface.; Similarity: the predicted protein shows much stronger similarity to a N. crassa and a S. cerevisiae hypothetical proteins.; Title: strong similarity to iron-phytosiderophore transporter protein yellow stripe 1 ys1 - Zea mays [putative frameshift]; plasma membrane; putative frameshift; See PMID 11201743
An08g06710	Catalytic activity: (R)-glycerate + NAD(+) = hydroxypyruvate + NADH.; Complex: HPRA of M. extorquens is a homodimer.; Function: HPRA of M. extorquens plays a central role in assimilation of carbon; it converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate.; Pathway: serine pathway.; Title: strong similarity to hydroxypyruvate dehydrogenase HPRA - Methylobacterium extorquens; See PMID 8144463; See PMID 1657886; See PMID 1729225
An08g06720	Catalytic activity: phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O (acts also on monohydroxy-, monohalo-,monoamino- and monomethylphenols).; Complex: phenol hydroxilase of T. cutaneum is a homodimer.; Pathway: phenol hydroxilase, also called phenol 2-monooxygenase, catalyzes the first step of phenol biodegradation.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 2298204; See PMID 1429434
An08g06730	Title: weak similarity to hypothetical protein CAD29600.1 - Aspergillus fumigatus
An08g06740	Similarity: the BLASTP hits are due to the high content of low-complexity regions.; Title: weak similarity to hypothetical 1,4-beta-cellobiosidase XF1267 - Xylella fastidiosa
An08g06750	Complex: RAV1 of S. cerevisiae, with RAV2 and SKP1 form a complex called RAVE, regulator of the (H+)-ATPase of the vacuolar and endosomal membranes (V-ATPase).; Function: the RAVE complex promotes the glucose-triggered assembly of the V-ATPase holoenzyme.; Remark: RAV1 of S. cerevisiae is also called YJR033c.; Remark: V-ATPases are conserved throughout eukaryotes, and have been implicated in tumour metastasis and multidrug resistance.; Title: strong similarity to regulator protein Rav1 -Saccharomyces cerevisiae; See PMID 11283612
An08g06760	Remark: SFI1 of S. cerevisiae is an essential gene and is required for cell cycle progression, more specifically for progression through G(2)-M transition. the protein might be required for correct mitotic spindle assembly and its precise role might be in chromosome condensation.; Remark: Sfi1 may be a downstream target of the protein kinase A pathway.; Title: similarity to suppressor of fil1 Sfi1 -Saccharomyces cerevisiae; See PMID 10455233
An08g06770	Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + pyrophosphate + L-isoleucyl-tRNA(Ile).; Pathway: valine, leucine and isoleucine biosynthesis; aminoacyl-tRNA biosynthesis.; Remark: also strong similarity to isoleucyl-tRNA synthetase protein sequence from Candida albicans patent US5885815-A.; Remark: isoleucyl-tRNA synthetase ILS1 of S. cerevisiae is essential.; Similarity: belongs to the class I aminoacyl-tRNA synthetase family.; Title: strong similarity to cytoplasmic isoleucine--tRNA ligase Ils1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2663194; See PMID 3311074; See PMID 10466139
An08g06780	Domain: the rodlike tail sequence is highly repetitive, composed of an heptapeptide repeat pattern characteristic of alpha-helical coiled coils. may form filamentous structures in the cell.; Function: required for protein transport from the ER to the golgi complex.; Localization: cytoplasmic. associated with intracellular membranes. probably present on vesicles operational between the ER and the golgi complex.; Remark: best blastP match to unknown gene B13I18. 10 of Neurospora crassa, which is related to transport protein USO1.; Similarity: belongs to the p115(tap)/uso1/ybl047c family.; Title: strong similarity to transport protein Uso1 -Saccharomyces cerevisiae; cytoplasm; See PMID 2010462; See PMID 8603910
An08g06790	Function: genetic experiments showed that dhp1+ of S. pombe on an S. cerevisiae expression vector could rescue both the defects of the S. cerevisiae DST2 disruptant,slow growth rate and a sporulation defect, and the lethality of the S. cerevisiae rat1ts mutation. This implies the functional similarity of dhp1+ to both DST2 and RAT1.; Remark: RAT1/HKE1 of S. cerevisiae is involved in RNA trafficking and processing.; Remark: STP beta of S. cerevisiae is required for homologous recombination in both mitotic or meiotic cells.; Remark: dhp1+ of S. pombe is an essential gene for cell growth in S. pombe, suggesting that dhp1+ is not the true homologue of DST2 but rather of RAT1 in S. pombe.; Similarity: strong similarity to STP beta (encoded by the DST2 gene) of S. cerevisiae and RAT1/HKE1 of S. cerevisiae.; Title: strong similarity to DNA exoribonuclease dhp1p - Schizosaccharomyces pombe
An08g06800	Remark: C-terminal truncated ORF due to end of contig.; Remark: a splice site was detected upstream of the START codon.; Remark: the AROM locus of Aspergillus nidulans specifies a pentafunctional polypeptide catalysing five consecutive steps leading to the production of 5-enolpyruvylshikimate 3-phosphate in the shikimate pathway. the whole AROM locus and various overlapping subfragments from within it have been expressed in appropriate aro mutants of E. coli to delineate functional domains within the arom polypeptide. the arom polypeptide falls in two independently folding and functioning regions,the N-terminal half specifying 3-dehydroquinate (DHQ) synthase and EPSP synthase and the C-terminus specifying shikimate kinase, biosynthetic 3-dehydroquinase (DHQase) and shikimate dehydrogenase.; Title: strong similarity to penta-functional enzyme aROM - Aspergillus nidulans [truncated ORF]; See PMID 2836080; See PMID 1849480
An08g06810	Catalytic activity: the AROM protein in A. nidulans contains five separate enzymatic domains (3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate 5-dehydrogenase, shikimate kinase, EPSP synthase).; Pathway: the AROM protein in A. nidulans catalyses five consecutive enzymatic steps leading to the production of 5-enolpyruvylshikimate 3-phosphate (EPSP) in the shikimate pathway.; Remark: a putative sequencing error results in an frameshift.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to pentafunctional enzyme aroM - Aspergillus nidulans [truncated ORF] [putative frameshift]; cytoplasm; putative frameshift; See PMID 8383607; See PMID 8393515
An08g06820	Title: questionable ORF
An08g06830	Title: questionable ORF
An08g06850	Function: hypothetical C2H2 zinc-finger protein,contains 3 putative C2H2 motives (Pfam); Similarity: C-terminus also shows similarity to 26S proteasome regulatory particle chain RPN4 (nuclear protein SON1, Ub fusion degradation protein 5) of S. cerevisiae.; Similarity: only C-terminus shows similarity to hypothetical C2H2 zinc-finger protein of S. pombe.; Title: similarity to hypothetical C2H2 zinc-finger protein SPBC1105.14 - Schizosaccharomyces pombe
An08g06880	Similarity: N-terminal part shows weak similarity to S-adenosylmethionine decarboxylases of diverse plant species.
An08g06890	Remark: ubiG of E. coli is also known as 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase.; Similarity: shows weak similarity to several bacterial and eukaryotic methyltransferases of different specificities.; Similarity: the similarity covers only the central part of the protein, C- and N-terminus shows no similarity.; Title: weak similarity to 3-demethylubiquinone-9 3-O-methyltransferase ubiG - Escherichia coli
An08g06940	Function: histone H4 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Title: strong similarity to histone H4.1 -Aspergillus nidulans; nucleus; See PMID 2274040
An08g06960	Function: histone H3 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Function: histone H3 lysin 9 methylation by Clr4 in S. pombe is necessary for Swi6 mediated gene silencing.; Similarity: deduced aa sequence is identical to histone H3 of E. nidulans.; Title: strong similarity to histone H3 - Aspergillus nidulans; nucleus; See PMID 2274040; See PMID 11242054
An08g06980	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: FLU1 and MDR1 of C. albicans are members of the major falicitator superfamily; Similarity: N-terminus is ca. 90 aa shorter and C-terminus ca. 90 aa longer than in FLU1 of C. albicans; Similarity: similar to the MDR1 (formerly BEN(r)/BMR) protein of C. albicans; Similarity: strong similarity (including the very C-terminus) to hypothetical mdr protein of Penicillium olsonii; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353
An08g06990	Title: similarity to hypothetical membrane protein YLR251w - Saccharomyces cerevisiae
An08g07000	Title: similarity to hypothetical protein CAF32094.1/AfA19D12.030 - Aspergillus fumigatus
An08g07010	Title: similarity to hypothetical protein mlr7324 -Mesorhizobium loti
An08g07020	Phenotype: deletion of the ALG9 gene leads to accumulation of lipid-linked Man6GlcNAc2 in vivo and to hypoglycosylation of secreted proteins.; Remark: protein N1295; protein YNL219c are alternative names for Alg9; Title: similarity to mannosyl transferase Alg9 -Saccharomyces cerevisiae; See PMID 8692962
An08g07030	Title: similarity to hypothetical protein YNL124w -Saccharomyces cerevisiae
An08g07040	Function: PRP3 of S. cerevisiae is required for assembly of spliceosomes from prespliceosomes.; Phenotype: S. cerevisisae prp3-1 mutant exhibits altered assembly or stability of U4/U6 snRNP.; Remark: RNA3 is an alternative name for PRP3.; Title: similarity to splicing factor Prp3 -Saccharomyces cerevisiae; nucleus; See PMID 9326489; See PMID 9826507
An08g07050	Function: active RNA polymerase I is required for the formation of the chromosome nucleolus.; Remark: RPA190 of S. pombe is also called nuc1,SPRPA190 or SPBC4c3. 05c.; Title: strong similarity to 189 kD subunit of DNA-directed RNA polymerase I rpa190p - Schizosaccharomyces pombe; nucleus; See PMID 2854522
An08g07060	Phenotype: S. pombe rad15 gene is essential for viability, suggesting that the protein product has a role in cell proliferation and not solely in DNA repair.; Phenotype: the S. pombe rad15. P mutant is highly sensitive to UV radiation, but only slightly sensitive to ionising radiation, as expected for a mutant defective in excision repair.; Remark: RHP3 or SPAC1D4 are alternative names for RAD15 in S. pombe.; Title: strong similarity to subunit of transcription initation factor TFIIH DNA repair helicase rad15p -Schizosaccharomyces pombe; nucleus; See PMID 1319571; See PMID 1534406
An08g07070	Function: the protein from patent WO9964455-A1 is involved in nuclear transport.; Title: similarity to nuclear transport protein clone hfb341 from patent WO9964455-A1 - Homo sapiens; nucleus
An08g07080	Function: No direct effects on phosphatase activity changes were observed upon methylation of the dimeric or trimeric forms of PP2A.; Function: human LCMT methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2a catalytic subunits (PP2CA) to form alpha-leucine ester residues.; Similarity: human LCMT is distinct from other known protein methyltransferases, sharing only sequence motifs supposedly involved in the binding of adenosylmethionine; Title: strong similarity to leucine carboxyl methyltransferase LCMT - Homo sapiens; See PMID 10600115
An08g07090	Phenotype: Sim1 disruption allows clb1 clb2 clb3 clb4 quadruple null mutants to perform DNA re-replication before blocking in G2.; Phenotype: Sim1 mutants have a longer lifespan and better viability upon starvation.; Title: similarity to protein Sim1 - Saccharomyces cerevisiae; See PMID 8574583
An08g07100	Title: strong similarity to hypothetical protein CAF32105.1 - Aspergillus fumigatus
An08g07110	Similarity: the ORF encoded protein also shows weak similarity to tetracycline transporters of several species as well as two PFAM transporter motifs.; Title: similarity to hypothetical transport protein YCR023c - Saccharomyces cerevisiae
An08g07120	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An08g07150	Title: similarity to hypothetical protein mlr2056 -Mesorhizobium loti
An08g07200	Complex: the subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin,AP50, and AP17.; Function: AP17 is a component of the clathrin-associated protein complexes found in coated structures of the plasma membrane and is believed to interact with cytoplasmic domains of receptors found in the plasma membrane.; Title: strong similarity to clathrin-associated protein 17 - Rattus norvegicus; plasma membrane; See PMID 7593184; See PMID 2040623; See PMID 2495531
An08g07210	Title: strong similarity to hypothetical protein CAF32111.1 - Aspergillus fumigatus
An08g07220	Function: DPH5 of S. cerevisiae converts S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine to S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine.; Pathway: Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2.; Remark: YLR172c ist the systematic name for DPH5 of S. cerevisiae.; Title: strong similarity to diphthamide methyltransferase Dph5 - Saccharomyces cerevisiae; See PMID 6717439; See PMID 1508200
An08g07230	Complex: SPT3 from S. cerevisiae is part of the SAGA complex.; Function: SPT3 from S. cerevisiae is required for the initiation of TY transcription from the delta promoter.; Remark: BLU1 and YDR392w are alternative names for SPT3.; Title: strong similarity to regulator protein Spt3 -Saccharomyces cerevisiae; nucleus; See PMID 3020500
An08g07240	Title: strong similarity to hypothetical blue-light-inducible protein bli-3 - Neurospora crassa
An08g07250	Title: similarity to hypothetical protein EAA58154.1 - Aspergillus nidulans
An08g07270	Function: F. sporotrichioides TRI7 (FsTRI7) is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533
An08g07280	Function: S. aureus hmrA conferred Eagle-type resistance, i. e. resistance to high concentrations of methicillin (64 to 512 microg/ml) and susceptibility to low concentrations of methicillin (2 to 16 microg/ml), when introduced into the cell in multiple copies.; Similarity: the predicted A. niger protein shows similarity to several putative hydrolase proteins and contains a hydrolase BLOCKs motif.; Title: strong similarity to methicillin resistance gene HmrA - Staphylococcus aureus; See PMID 11181367
An08g07290	Catalytic activity: aldehyde + NAD+ + H2O = acid + NADH.; Gene-ID: aldA; Pathway: aldehyde dehydrogenase of A. niger catalyzes the second step in ethanol utilization.; Similarity: aldehyde dehydrogenase of A. niger belongs to the aldehyde dehydrogenases family.; See PMID 1644309
An08g07310	Title: strong similarity to hypothetical protein all4736 - Nostoc sp.
An08g07320	Title: strong similarity to hypothetical conserved protein SCD10.11 - Streptomyces coelicolor
An08g07330	Phenotype: the rad32 mutant undergoes decreased meiotic recombination and displays reduced stability of minichromosomes.; Phenotype: the rad32 mutant, in comparison to wild type cells, has decreased ability to repair DNA double strand breaks.; Similarity: rad32 of S. pombe shows similarity to the meiotic recombination gene MRE11 of S. cerevisiae.; Title: strong similarity to DNA repair phosphoesterase rad32p - Schizosaccharomyces pombe; nucleus; See PMID 7885834
An08g07340	Title: weak similarity to hypothetical F-box domain protein - Schizosaccharomyces pombe
An08g07350	Phenotype: gas1 muntants show altered cell wall glucan levels, they are reduced in beta1,3-glucan.; Phenotype: gas1delta cells release beta1,3-glucan into the medium indicating that Gas1p is indeed involved in the incorporation of 1,3-glucan in the cell wall.; Remark: GGP1, GP115 CWH52 and YMR307w are alternative names for Gas1 in S. cerevisisae.; Title: strong similarity to precursor of glycophospholipid-anchored surface glycoprotein Gas1 -Saccharomyces cerevisiae; plasma membrane; See PMID 9515908
An08g07360	Complex: forms part of the receptor complex that consists of at least 8 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM37, TOM40 and TOM70).; Function: TOM20 together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.; Function: the TOM20 protein of N. crassa is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.; Localization: TOM20 is an integral membrane protein in the mitochondrial outer membrane.; Remark: mitochondrial 20 kDa outer membrane protein,MOM19 protein and translocase of outer membrane 20 kDa subunit are alternative names for TOM20 in N. crassa.; Title: strong similarity to mitochondrial import receptor TOM20 - Neurospora crassa; localisation:mitochondrion; See PMID 1661031
An08g07370	Function: Exo84p of S. cerevisiae is involved in vesicle targeting and establishment of cell polarity.; Localization: Exo84p specifically localizes to the bud tip or mother/daughter connection, sites of polarized secretion.; Phenotype: Yeast cells depleted of Exo84p cannot survive. These cells are defective in invertase secretion and accumulate vesicles similar to those in the late sec mutants.; Remark: YBR102C is the systematic name for Exo84p.; Title: similarity to exocyst protein Exo84 -Saccharomyces cerevisiae; plasma membrane; See PMID 10438536
An08g07380	Remark: the ORF encoded protein also shows strong similarity to protein fragment SEQ ID NO:20088 of A. thaliana from patent number G18610.; Similarity: the ORF encoded protein also shows strong similarity to long-chain-fatty-acid-CoA ligases of different species.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii; See PMID 9826185
An08g07390	Similarity: her1 of Rhodococcus belongs to the carboxylesterase type-b family.; Title: similarity to heroin esterase her -Rhodococcus sp.; See PMID 9143135
An08g07400	Function: TNA1 of S. cerevisiae is involved in the uptake of nicotinic acid.; Localization: TNA1 of S. cerevisiae is an integral membrane protein.; Remark: YGR260W is the systematic name for TNA1 of S. cerevisiae.; Remark: the ORF encoded protein also shows similarity to allantoate permeases.; Similarity: TNA1 of S. cerevisiae belongs to the allantoate permease family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563
An08g07420	Catalytic activity: bicarbonate + L-glutamine + H2O + 2ATP = carbamoylphosphate + L-glutamate + phosphate + 2ADP (EC 6. 3. 5. 5).; Catalytic activity: carbamoylphosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate (EC 2. 1. 3. 2).; Function: pyrABCN of A. nidulans produces N-carbamoyl-L-aspartate, the substrate of dihydroorotase.; Pathway: pyrABCN of A. nidulans catalyzes the first two steps in the pyrimidine nucleotide de novo synthesis.; Similarity: pyrABCN of A. nidulans contains an evolutionary remnant of a dihydroorotase-encoding sequence.; Title: strong similarity to multifunctional pyrimidine biosynthesis enzyme pyrABCN - Aspergillus nidulans; See PMID 10417650
An08g07430	Remark: Closest Blastp hit to product Citron-K kinase R. n. E. val. : 0. 31.; Title: weak similarity to product Citron-K kinase -Rattus norvegicus; See PMID 9697773
An08g07440	Title: weak similarity to desaturase/cytochrome b5 protein - Ricinus communis; See PMID 9108131
An08g07450	Title: weak similarity to protein-tyrosine-phosphatase, receptor type kappa precursor, R-PTP-kappa - Mus musculus; See PMID 8474452
An08g07460	Remark: TRP2 (R. n.), the closest manual Blastp hit, shows an E. val. of 0. 001.; Remark: TRP2 from Rattus norvegicus is a candidate transduction channel for mammalian pheromone sensory signaling.; Title: similarity to transient receptor potential family member TRP2 - Rattus norvegicus; See PMID 10318963
An08g07465	Title: strong similarity to hypothetical protein CAD37162.1 - Aspergillus fumigatus
An08g07470	Localization: VAMP-7 from Rattus norvegicus is most concentrated in the trans-Golgi network region of the cell as well as late endosomes and transport vesicles that do not contain the mannose-6 phosphate receptor.; Title: similarity to VAMP-7 vesicle-associated membrane protein-7 - Rattus norvegicus; See PMID 10459012; See PMID 10888671
An08g07480	Title: similarity to eyelid - Drosophila melanogaster; See PMID 9271118
An08g07485	Remark: the annotated protein is N-terminally shorter than the matching N. crassa protein.; Title: similarity to hypothetical protein CAD21183.1 - Neurospora crassa
An08g07490	Remark: the A. nidulans FacB transcriptional regulator belongs to the fungal Zn(II)2Cys6 family.; Remark: the closest manual Blastp hit A. nidulans FacB shows an E. val. of 0. 002.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An08g07510	Complex: MDR1 interacts with S. cervisiae Mac1 protein.; Function: S. cerevisiae Mdr1/Gyp2p is an efficient GAP (Ras- and Rho-specific GTPase-activating protein) for Ypt6p and Sec4p, that are involved in regulating different steps of exo- and endocytic transport routes.; Remark: MDR1 of S. cerevisiae is also known as MIC1 or GYP2. the systematic name is YGR100W.; Similarity: only the similarity of the ORF coded protein to the hypothetical protein SPAC4G8. 04 (S. pombe) shows a large extention.; Similarity: the predicted A. niger protein shows similarity to the MDR1 protein of S. cerevisiae, which belongs to a large family of Ypt/Rab-GAPs.; Title: similarity to protein Mdr1 - Saccharomyces cerevisiae; See PMID 10559187
An08g07520	Catalytic activity: 3-oxoacyl-(acyl carrier protein) reductases convert (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Catalytic activity: the levodione reductase from C. aquaticum catalyzed regio- and stereo selective reduction of levodione to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol).; Similarity: the ORF shows strong similarity to hypothetical and experimental validated 3-oxoacyl-(acyl carrier protein) reductases (EC:1. 1. 1. 100). Therefore it is not clear if the ORF encoded A. niger protein is involved in fatty acid- or in polyketid synthesis.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066
An08g07530	Remark: the D. melanogaster CRAG-protein was found as Calmodulin binding factor expressed in the Drosophila retina.; Similarity: the D. melanogaster CRAG-protein is related to Rab3 GTPase exchange proteins.; Title: similarity to protein CRAG - Drosophila melanogaster; See PMID 9813038
An08g07540	Function: Pichia pastoris PER6 gene product is a peroxisomal membrane protein essential for peroxisome biogenesis and has sequence.; Title: strong similarity to protein PER6 - Pichia pastoris; peroxisome; See PMID 8993620; See PMID 8628321
An08g07550	Remark: Drosophila TRP proteins are essential for light-activated,phosphatidyl-inositide (PI)-dependent Ca2+ conductance in Drosophila photoreceptors.; Remark: the mouse TRP4 protein is a homolog of Drosophila class of TRP channels.; Title: similarity to receptor-activated cation channel TRP4 - Mus musculus; See PMID 9512398
An08g07560	Remark: the ORF coded protein also shows weak similarities to some zinc finger proteins, so it could probably be a transcription factor.; Title: similarity to hypothetical protein CAD37151.1 - Aspergillus fumigatus
An08g07570	Catalytic activity: isopentenyl diphosphate <=> dimethylallyl diphosphate.; Pathway: IDI1 gene product of S. cerevisiae is involved isoprene biosynthesis; cholesterol biosynthesis.; Title: strong similarity to isopentenyl-diphosphate Delta-isomerase Idi1 - Saccharomyces cerevisiae; See PMID 2681212
An08g07580	Remark: hypothetical protein L5075. 03 from Leishmania major is possible negative regulator of cdc42p.; Title: weak similarity to hypothetical protein L5075.03 - Leishmania major
An08g07590	Remark: the ERC1 gene product of S. cerevisiae interacts with YDL012c in vivo (see Pubmed 10688190).; Title: strong similarity to ethionine resistance protein Erc1 - Saccharomyces cerevisiae; See PMID 10688190
An08g07600	Complex: the ssb2 gene product is subunit of a complex with 68, 30, and 12 kDa chains.; Function: the ssb2 gene product from S. pombe binds single stranded sequences.; Remark: the ssb2 gene product from S. pombe becomes phosphorylated in a cell-cycle-dependent manner.; Title: strong similarity to single-stranded DNA binding protein 30k chain ssb2p - Schizosaccharomyces pombe; See PMID 8702843
An08g07610	Remark: DRS1=deficiency of ribosomal subunits.; Remark: the S. cerevisiae DRS1 gene product is a putative RNA helicase of the DEAD box family.; Title: strong similarity to ATP-dependent RNA helicase involved in ribosome assembly Drs1 - Saccharomyces cerevisiae; nucleus; See PMID 1454790
An08g07620	Title: similarity to hypothetical protein EAA63156.1 - Aspergillus nidulans [truncated ORF]
An08g07630	Title: strong similarity to hypothetical oxidoreductase of the short-chain dehydrogenase/reductase family - Deinococcus radiodurans
An08g07650	Remark: truncated ORF due to end of contig.
An08g07690	Remark: blastORFEmbl and blastp hits are caused by repetetive sequence motives.
An08g07700	Remark: unusual genestructure due to large intron.; Similarity: blastp hits might be caused by repetitive sequence motives.; Title: weak similarity to histone 1 protein H1 -Mytilus edulis
An08g07710	Title: strong similarity to hypothetical C6 hypothetical protein CAD37146.1 - Aspergillus fumigatus
An08g07740	Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Remark: ORF might be truncated for about 120 aa due to end of contig.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides [truncated ORF]; See PMID 1368015; See PMID 1773059
An08g07750	Remark: truncated ORF due to end of contig.
An08g07770	Remark: alternate name = YGR055W.; Remark: the MUP1-homologue of Aspergillus niger is probably located in the plasma membrane due to its 7 integral membrane domains.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; See PMID 8893857
An08g07780	Title: strong similarity to lysine-specific permease lysP - Escherichia coli; See PMID 7888172; See PMID 1315732
An08g07790	Function: DBP4 from S. cerevisiae can suppress the rRNA processing function of the U14 small nucleolar RNA.; Function: DBP4 from S. cerevisiae is predicted to function either in assembly of the U14 small nucleolar RNP or, more likely, in its interaction with other components of the rRNA processing apparatus.; Remark: DBP4 from S. cerevisiae belongs to the DEAD-DEXH box family.; Remark: an alternative name for DBP4 is CA4.; Title: strong similarity to RNA helicase Dbp4 -Saccharomyces cerevisiae; See PMID 9199348; See PMID 9747670
An08g07800	Function: human Spf31 is a nuclear DNAj-like protein which interferes with pre-mRNA splicing.; Remark: information regarding human spf31 has not been published and is available from http://www. protana. com/publics/default. asp.; Similarity: shows weak similarity to heat shock protein HSP40-3 from M. musculus.; Title: similarity to hypothetical spliceosome associated protein Spf31 - Homo sapiens; nucleus
An08g07810	Catalytic activity: fmn adenyltransferases convert ATP + FMN to diphosphate + FAD.; Function: Fad1p of S. cerevisiae adenylates FMN to FAD.; Localization: FAD synthetase of S. cerevisiae is a soluble cytosolic enzyme.; Remark: Fad1p is an essential gene in S. cerevisiae,null mutants are non-viable.; Title: similarity to flavin adenine dinucleotide synthase Fad1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7799934
An08g07820	Localization: RBMS3 of H. sapiens mostly localizes to the cytoplasm.; Remark: MSSPs are believed to regulate DNA replication, transcription, apopotosis and cell cycle progression by interacting with the C-MYC protein.; Remark: RBMS3 of H. sapiens contains two pairs of RNA binding motifs and is closely related to the structure of the c-myc gene single-strand binding proteins (MSSPs).; Title: similarity to RNA-binding protein RBMS3 -Homo sapiens; See PMID 10675610
An08g07830	Complex: human Damaged DNA Binding protein (DDB) is a heterodimer of 48 (DDB2) and 127 kDa (DDB1) subunits.; Function: human Damaged DNA Binding protein (DDB) binds to UV damaged DNA and is involved in excision repair (directly or indirectly).; Title: similarity to damage-specific DNA binding protein DDB1 - Homo sapiens; See PMID 8530102; See PMID 10713455
An08g07840	Catalytic activity: A. niger CprA converts NADPH + 2 Ferricytochrome to NADP+ + 2 Ferrocytochrome.; Function: A. niger CprA also reduces cytochrome b5 and cytochrome c.; Function: A. niger CprA catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system.; Gene-ID: cprA; Induction: expression of A. niger CprA is induced by benzoic acid.; Mapping: cprA from A. niger is mapped to chromosome VIII; see list from DMS.; Remark: A. niger CprA is a flavoprotein, cofactors are FMN or FAD.; Remark: an alternative name for A. niger CprA is NADPH-ferrihemoprotein reductase.; Remark: some mismatches between the data bank entry and this ORF might also be due to sequencing errors.; Remark: this ORF has 5 frame shifts which might be due to sequencing errors.; endoplasmatic reticulum; See PMID 7646819; See PMID 8987724; See PMID 10852481
An08g07850	Remark: this region is involved in benzoate induction of cprA gene expression of A. niger.; Remark: this region of A . niger is described as transcription control region of the cprA gene.; Title: questionable ORF; See PMID 10852481
An08g07860	Remark: this region is involved in benzoate induction of cprA gene expression of A. niger.; Remark: this region of A . niger is described as transcription control region of the cprA gene.; Title: questionable ORF; See PMID 10852481
An08g07870	Function: in S. cerevisiae tao3 mutants activate OCH1 transcription and form aggregates.; Remark: information regarding TAO3 has not been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Title: strong similarity to transcription activator Tao3 - Saccharomyces cerevisiae
An08g07890	Catalytic activity: 3-hydroxyisobutyrate dehydrogenases convert 3-Hydroxy-2-methylpropanoate + NAD+ to 2-Methyl-3-oxopropanoate + NADH.; Function: MmsB of P. aeruginosa is an oxidoreductase, it is acting on the CH-OH group of donors with NAD+ or NADP+ as acceptor.; Pathway: P. aeruginosa MmsB is involved in valine,leucine and isoleucine biosynthesis and degradation.; Title: strong similarity to 3-hydroxyisobutyrate dehydrogenase MmsB - Pseudomonas aeruginosa; See PMID 1339433
An08g07900	Title: weak similarity to protein #2506 from patent WO200177335-A2 - Listeria monocytogenes
An08g07910	Function: PDAT9 of N. haematococca detoxifies the phytoalexin pisatin, an antimicrobial compound produced by garden pea in response to infection by this plant pathogen.; Remark: PDAT9 is associated with high virulence.; Remark: based on its amino acid sequence PDAT9 of N. haematococca has been assigned to the new cytochrome P450 family CYP57.; Remark: detoxification of pisatin in N. haematococca is controlled by a family of PDA (pisatin demethylating ability) genes.; Remark: six known PDA genes each encode characteristic levels of inducible enzyme activity and are associated with different degrees of virulence on pea.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 8076822; See PMID 8208242
An08g07920	Catalytic activity: phenol hydroxylases convert phenol + NADPH + O2 to catechol + NADP+ + H2O.; Pathway: T. cutaneum phenol 2-monooxygenase is invovled in phenylalanine metabolism,gamma-hexachlorocyclohexane degradation, toluene degradation, first step of phenol degradation.; Remark: T. cutaneum phenol 2-monooxygenase is a flavoprotein (FAD) it is also active with resorcinol and o-cresol.; Remark: T. cutaneum phenol 2-monooxygenase is an oxidoreductase, it is acting on paired donors with incorporation of molecular oxygen with NADH or NADPH as one donor, and incorporation of one atom of oxygen.; Title: similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434
An08g07930	Function: LAC9 of K. lactis controls induction of the lactose-galactose regulon.; Similarity: K. lactis LAC9 is structurally and functionally related to GAL4 of S. cerevisiae.; Similarity: similarity is between the central regions of the predicted A. niger protein and several transcription factors.; Title: similarity to positive regulator of the lactose-galactose regulon LAC9 - Kluyveromyces lactis; nucleus; See PMID 3550430
An08g07940	Title: similarity to hypothetical protein CAC28695.1 - Neurospora crassa
An08g07950	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An08g07960	Catalytic activity: Fun49 of S. cerevisiae catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to (3R)-acetoin and (3S)-acetoin,respectively.; Complex: Fun49 of S. cerevisiae is a homodimer.; Function: Fun49 of S. cerevisiae is an NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase acting on the CH-OH group of donors with NAD+ as acceptor.; Remark: alternative names for Fun49 of S. cerevisiae are Bdh and YAL060W.; Title: similarity to butanediol dehydrogenase Fun49 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 10938079
An08g08000	Function: the MAL31 protein from yeast is a high affinity maltose/H+ symporter (maltose permease).; Remark: the MAL31 protein from yeast is a member of the hexose transporter family of the major facilitator superfamily (MFS).; Title: strong similarity to maltose transport protein Mal31 - Saccharomyces cerevisiae; See PMID 7483839; See PMID 2549370
An08g08010	Title: similarity to hypothetical protein MmcH -Streptomyces lavendulae
An08g08020	Function: bah of S. hygroscopicus is also involved in self defence agianst bialaphos.; Function: bah of S. hygroscopicus removes the N-acetyl group from bialaphos (antibiotic) and is one of the final steps in the bialaphos biosynthetic pathway.; Title: similarity to bialaphos acetylhydrolase bah -Streptomyces hygroscopicus; See PMID 3209476
An08g08030	Catalytic activity: pnbA of B. subtilis converts a carboxylic ester + H2O to alcohol + carboxylate.; Function: pnbA of B. subtilis is involved in the biosynthesis of betalactam antibiotics.; Title: strong similarity to para-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905
An08g08040	Remark: similarity to S. pombe SPBC1105. 07c is restricted to the N-terminal part of the protein.; Title: similarity to hypothetical protein SPBC1105.07c - Schizosaccharomyces pombe
An08g08050	Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF
An08g08060	Catalytic activity: N,N-Dimethylaniline + NADPH + O2 = N,N-Dimethylaniline N-oxide + NADP+ + H2O.; Remark: FMO appears to be ideally adapted to catalyse the detoxification of structurally diverse soft nucleophiles (e. g. alkaloids with basic side-chains and organic sulfur xenobiotics) so abundant in food derived from plants.; Remark: flavin-containing monooxygenases (FMOs) have been identified in various organisms from bacteria to humans.; Remark: similar to patent W49699 Human flavin-containing mono-oxygenase 2.; Title: strong similarity to flavin-containing monooxygenase FMO5 - Cavia porcellus; See PMID 7872795; See PMID 9972460; See PMID 2203193
An08g08070	Remark: seladin-1 is a human homolog of the DIMINUTO/DWARF1 gene described in plants and Caenorhabditis elegans. Its sequence shares similarities with flavin-adenin-dinucleotide (FAD)-dependent oxidoreductases.; Remark: seladin-1 is an important factor for the protection of cells against Abeta toxicity and oxidative stress, and they suggest that seladin-1 may be involved in the regulation of cell survival and death.; Remark: the Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis.; Title: strong similarity to seladin-1 - Homo sapiens; See PMID 11007892
An08g08080	Catalytic activity: a 5'-Ribonucleotide + H2O = a Ribonucleoside + Orthophosphate.; Pathway: Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism.; Remark: there are 5-7 domains highly conserved in procaryotes and vertebrates in enzymes exhibiting 5'-nucleotidase, 3'-nucleotidase or phosphodiesterase activity.; Title: strong similarity to 5-nucleotidase 5NTD_DISOM - Discopyge ommata; See PMID 10506947; See PMID 1765099
An08g08090	Title: similarity to hypothetical protein CAD21290.1 - Neurospora crassa
An08g08100	Remark: N-terminal truncated ORF due to end of contig.; Remark: the protein shows weak similarity to different zinc finger containing transcription activators in different organisms.; Title: similarity to hypothetical transcriptional regulator CAF32162.1 - Aspergillus fumigatus [truncated ORF]
An08g08110	Remark: C-terminal truncated orf due to end of contig.; Similarity: shows strong similarity to C-terminal half of An06g00330.; Title: similarity to hypothetical protein encoded by An06g00330 - Aspergillus niger [truncated ORF]
An08g08120	Title: similarity to hypothetical protein sll0676 -Synechocystis sp.
An08g08130	Title: weak similarity to hypothetical ankyrin-like protein T22P11_210 - Arabidopsis thaliana
An08g08140	Catalytic activity: Digallate + H2O = 2 Gallate.; Remark: tannase consisted of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An08g08150	Title: weak similarity to hypothetical protein T8B10.110 - Arabidopsis thaliana
An08g08160	Remark: there is a small domain wich is shows similarity to c terminal region of beta transducin-like protein - Podospora anserina.; Title: similarity to hypothetical protein EAA66849.1 - Aspergillus nidulans
An08g08180	Title: questionable ORF
An08g08190	Remark: the 3,6-dideoxyhexoses are found in the lipopolysaccharides of gram-negative bacteria, where they have been shown to be the dominant antigenic determinants. Of the five 3,6-dideoxyhexoses known to occur naturally,four have been found in various strains of Salmonella enterica (abequose, tyvelose, paratose, and colitose).; Title: weak similarity to CDP-3,6-dideoxy-L-glycero-D-glycero-4-hexulose-4-reductase -Yersinia pseudotuberculosis; See PMID 8071227
An08g08200	Title: similarity to hypothetical protein encoded by An14g02850 - Aspergillus niger
An08g08210	Remark: human actVA-ORF4-like protein useful in the treatment of infectious, vesicle trafficking, immunological and neoplastic disorders.; Remark: patent Y14147.; Remark: the similarity is only in the N-terminal region until aa 180; Title: weak similarity to human actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens
An08g08220	Remark: ATR1 encodes a Myb-like transcription factor that modulates ASA1 expression.; Remark: Expression of yeast ATR1 is enhanced in the presence of constitutively active alleles of YAP1 and GCN4.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9046086; See PMID 9576939
An08g08230	Title: weak similarity to hypothetical protein CAC01058.1 - Leishmania major
An08g08240	Catalytic activity: Hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Remark: BGLN showed maximum activity against the artificial substrate p-nitrophenyl beta-D-glucopyranoside.; Remark: It also hydrolyzed salicin, p-nitrophenyl beta-D-xyloside, cellobiose, and arbutin to a lesser extent. Fructose and SO(2) did not affect enzyme activity,which was activated by ethanol, while glucose was a strong competitive inhibitor.; Remark: strong similarity to Tomatinase Patent R85197.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; See PMID 10554245; See PMID 11137391
An08g08250	Remark: Aryl-alcohol oxidase (AAO) involved in lignin degradation by Pleurotus pulmonarius shows compared with other alcohol oxidases, 35% amino acid identity with glucose oxidase, showed highly conserved amino acid sequences in N-terminal and C-terminal regions, in spite of differences in substrate specificity.; Remark: it also shows strong similarity to glucose oxidase ggox Aspergillus niger.; Remark: the enzyme uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 8987726; See PMID 10606774
An08g08280	Remark: only the homeobox domain shows this similarity.; Remark: the similarity is to different homeobox proteins.; Title: weak similarity to homeobox protein slouch slou - Drosophila melanogaster; See PMID 10395544; See PMID 1980118
An08g08290	Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: the cephalosporin esterase from Rhodosporidium torulo has EC 3. 1. 1. 41.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399; See PMID 10878123
An08g08300	Title: strong similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa
An08g08310	Remark: involved in mitomycin resistance; oxidizes reduced form of mitomycins.; Similarity: to other oxygen oxidoreductases in different organisms that covalently bind FAD.; Title: strong similarity to mitomycin C resistance protein mcrA - Streptomyces lavendulae; See PMID 8917108; See PMID 10468636; See PMID 7517396
An08g08320	Title: weak similarity to transcription factor disco - Drosophila melanogaster
An08g08330	Remark: selection for the ability of S. cerevisiae cells to take up histidinol, the biosynthetic precursor to histidine, results in dominant mutations at HOL1.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 10874120
An08g08340	Title: similarity to hypothetical protein encoded by An07g02880 - Aspergillus niger
An08g08350	Remark: immunoglobulin variable region used by the ITC63B heavy chain (subgroup VH5).; Title: weak similarity to immunoglobulin variable region - Homo sapiens
An08g08360	Similarity: shows strong similarity to N-terminal half of An08g08380 .; Title: weak similarity to hypothetical protein encoded by An08g08380 - Aspergillus niger
An08g08370	Function: the 1,2-alpha-D-mannosidase aman2 from Bacillus sp. M-90 is an exo-1,2-alpha-D-mannanase. It is highly specific for alpha 1,2-linked D-mannose oligosaccharides.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_1842 Aspergillus niger.; Title: similarity to alpha-1,2-mannosidase aman2 -Bacillus sp.; See PMID 8149382
An08g08380	Similarity: N-terminal half shows strong similarity to An08g08360.; Title: weak similarity to hypothetical protein encoded by An08g08360 - Aspergillus niger
An08g08390	Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382
An08g08400	Function: TsaC from Comamonas testosteroni T-2 catalyzes the conversion of 4-sulfobenzyl alcohol or 4-carboxybenzyl alcohol to the corresponding aldehyde.; Title: strong similarity to toluenesulfonate zinc-independent alcohol dehydrogenase TsaC - Comamonas testosteroni; See PMID 9006050
An08g08410	Title: weak similarity to Arg/Abl-interacting protein ArgBP2b - Homo sapiens
An08g08430	Title: strong similarity to hypothetical protein SCF41.31c - Streptomyces coelicolor
An08g08440	Catalytic activity: N nucleoside triphosphate <=> N diphosphate + {RNA}(N).; Remark: the origin and the actual biological function(s) of plant-encoded RdRP have remained unresolved and are enigmatic because its cognate template(s) and in vivo transcription products remain unknown. Cellular RdRPs differ from virus RNA replicases.; Title: similarity to RNA-directed RNA polymerase RdRP - Lycopersicon esculentum; See PMID 9836747
An08g08450	Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: the Laccase II (lac2) from Podospora anserina is involved in lignin degradation and in the detoxification of lignin-derived products in its natural habitat (herbivorous dung), which is rich in lignin of grasses and straw. It is probably involved in melanin synthesis and in perithecia development.; Title: strong similarity to laccase II lac2 -Podospora anserina; See PMID 14600; See PMID 8914515
An08g08460	Title: weak similarity to human LYST-2 protein from patent WO9951741-A2 - Homo sapiens
An08g08470	Title: similarity to hypothetical transcription regulator SPAC18G6.01c - Schizosaccharomyces pombe
An08g08480	Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: the carbonyl reductase from Candida magnoliae is also described in patent WO9835025-A1.; Similarity: the ORF encoded protein shows also strong similarity to the functionally less characterized dehydrogenases Sou2 and Sou1 from C. albicans. C. albicans Sou(-) mutants are unable to utilize L-sorbose.; Title: strong similarity to NADPH-dependent carbonyl reductase S1 - Candida magnoliae; See PMID 10945260
An08g08490	Catalytic activity: phosphatidylcholine + H(2)O <=> 1-acylglycerophosphocholine + a fatty acid anion.; Title: similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412
An08g08500	Title: similarity to hypothetical DNA-binding protein SCF43A.34c - Streptomyces coelicolor
An08g08510	Catalytic activity: the aldh3 protein preferentially oxidizes aromatic aldehyde + NADP(+) + H2O = acid + NADPH.; Complex: the class 3 aldehyde dehydrogenase of H. sapiens forms a homodimer.; Function: aldehyde dehydrogenases are involved in the metabolism of corticosteroids, biogenic amines,neurotransmitters, and lipip aldehyde substrat peroxidation.; Function: aldehyde dehydrogenases play a major role in the detoxification of alcohol-derived acetaldehyde.; Remark: aldh3 of H. sapiens is a NADP-preferring aldehyde dehydrogenase.; Similarity: the predicted ORF overlaps with EST BE760482 of A. niger.; Title: strong similarity to aldehyde dehydrogenase aldh3 - Homo sapiens; cytoplasm; See PMID 8493892; See PMID 1737758
An08g08520	Function: hexose transporter family proteins of S. cerevisiae function in the cellular uptake of glucose.; Remark: alternate names for hxt17 are N3615 and YNR072w.; Remark: the hxt17 of S. cerevisiae belongs to the MAL61 superfamily of maltose transport proteins.; Similarity: the predicted ORF shows similarity to several members of the hexose facilitator family of S. cerevisiae.; Title: strong similarity to hexose transporter Hxt17 - Saccharomyces cerevisiae; plasma membrane; See PMID 10336421
An08g08530	Catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate.; Phenotype: ats mutants lose the ability to grow on aromatic sulfates as sole sulfur source.; Repression: synthesis of atsA is repressed when sulfate, cysteine or thiocyanate is supplied as the sole sulfur source for growth.; Title: strong similarity to arylsulfatase atsA -Pseudomonas aeruginosa; See PMID 7744061; See PMID 9748219
An08g08540	Function: GAPCenA is a GTPase activating protein for Rab6.; Localization: immunofluorescence and cell fractionation experiments show that GAPCenA is mainly cytosolic but that a minor pool is associated with the centrosome.; Pathway: GAPCenA may be involved in the coordination of microtubule and Golgi dynamics during the cell cycle.; Remark: the Rab6 GTPase regulates intracellular transport at the level of the Golgi apparatus.; Similarity: GAPCenA displays similarities, within a central 200 amino acids domain, to both the yeast Rab GTPase activating proteins (GAPs) and to the spindle checkpoint proteins S. cerevisiae Bub2p and Schizosaccharomyces pombe Cdc16p.; Title: strong similarity to Rab6 GTPase activating protein GAPCenA - Homo sapiens; See PMID 10202141
An08g08550	Function: top2 acts both as an enzyme and a structural component of the nuclear matrix where it regulates the topological states of DNA by transient cleavage, strand passing and re-ligation of double stranded DNA.; Remark: the action of top2 results in the decatenation of intertwined DNA molecules and relaxation of supercoiled DNA.; Remark: top2 has a role in DNA replication and is required for both condensation and segregation of chromosomes.; Title: strong similarity to DNA topoisomerase II top2 - Aspergillus nidulans; See PMID 9552399; See PMID 10452949
An08g08560	Function: FLU1 is a novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans conferring resistance to fluconazole.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An08g08570	Title: weak similarity to transcription repressor Xbp1 - Saccharomyces cerevisiae
An08g08590	Function: INCENP transports certain cytoskeletal proteins to the metaphase plate so that these proteins are able to subsequently participate in the assembly of the anaphase spindle and the cleavage furrow.; Remark: an internal 200 amino acid coiled-coil domain is required for binding of INCENP to cytoplasmic microtubules.; Remark: the amino-terminal 42-amino acid residues are required for transfer of INCENP from the chromosomes to the mitotic spindle at anaphase.; Title: similarity to class II inner centromere protein INCENP - Gallus gallus; See PMID 8408220
An08g08600	Remark: Disruption of the cwl1+ gene in S. pombe caused no noticeable phenotype.; Remark: Overexpression of the cwl1+ gene in S. pombe causes cell lysis when it is overexpressed in the absence of an osmotic stabilizer.; Title: similarity to protein cwl1p -Schizosaccharomyces pombe; See PMID 8873452
An08g08620	Title: similarity to hypothetical Ydr124wp-like protein - Pneumocystis carinii
An08g08660	Title: weak similarity to hypothetical microtubule-membrane-linker p210 - Spermatozopsis similis
An08g08670	Title: strong similarity to hypothetical signaling-associated PDZ domain containing protein CAB72237.1 - Schizosaccharomyces pombe
An08g08680	Title: weak similarity to merozoite surface protein 1 MSP1 - Plasmodium cynomolgi
An08g08690	Function: Cns1 of S. cerevisiae is an essential protein associated with the hsp90 chaperone complex.; Title: strong similarity to cyclophilin seven suppressor Cns1 - Saccharomyces cerevisiae; See PMID 9819421; See PMID 9819422; See PMID 9990037; See PMID 11604493
An08g08700	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An08g08710	Function: ATR1 is a S. cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.; Induction: ATR1 transcription is induced by aminotriazole and the ATR1 promoter region contains a binding site for the GCN4 activator protein.; Phenotype: multiple copies of ATR1 permit growth at extremely high concentrations of aminotriazole (80 mM),whereas a chromosomal deletion of ATR1 causes growth inhibition at very low concentrations (5 mM).; Similarity: ATR1 is a member of the multidrug-resistance 14-spanner (DHA14) family of the major facilitator superfamily (MFS-MDR).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970
An08g08720	Catalytic activity: 2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O.; Function: CCP1 is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7).; Function: the mitochondrial cytochrome c peroxidase CCP1 degrades reactive oxygen species within the mitochondria.; Title: strong similarity to cytochrome-c peroxidase precursor Ccp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6286684; See PMID 10589830
An08g08730	Remark: similarity is based on glutamine- and alanine-rich repeat region.; Title: weak similarity to transcription factor CA150 - Homo sapiens
An08g08740	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S18 - Homo sapiens; cytoplasm; See PMID 8441687; See PMID 8706699
An08g08750	Gene-ID: cpy; Mapping: cpy from A. niger is mapped to chromosome IV; see list from DSM.; Remark: a splice site was detected upstream of the START codon.
An08g08760	Title: similarity to colon cancer associated antigen precursor from patent WO9904265-A2 - Homo sapiens
An08g08770	Function: reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells. three kinases, SR protein-specific kinase (SRPK1 & 2) and Clk/Sty, have been shown to phosphorylate the SR family of splicing factors.; Remark: the ORF shows similarity to various protein kinases, not all are implicated in splicing factor phosphorylation.; Similarity: the predicted protein seems approximately only the half of the length of the blast homologs.; Title: similarity to serine kinase SRPK2 - Homo sapiens; See PMID 9472028
An08g08790	Remark: in Intron 2 there is a predicted Arg tRNA.
An08g08820	Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein ZK84.1 -Caenorhabditis elegans
An08g08830	Title: weak similarity to hypothetical L-lactate dehydrogenase mll6909 - Mesorhizobium loti
An08g08840	Catalytic activity: L-glutamate = 4-aminobutanoate + CO2.; Function: catalyzes the production of GABA. the calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.; Pathway: Glutamate metabolism; alanine and aspartate metabolism; beta-alanine metabolism; taurine and hypotaurine metabolism; butanoate metabolism.; Remark: the enzymatic activities of the pure recombinant GAD1 and GAD2 proteins were stimulated 35- and 13-fold, respectively, by Ca2+/calmodulin but not by Ca2+ or calmodulin alone. GAD1 transcript and a corresponding 58-kD peptide were detected in roots only.; Similarity: belongs to the glutamate decarboxylase and related PLP-dependent proteins.; Title: strong similarity to glutamate decarboxylase GAD1 - Arabidopsis thaliana; See PMID 7610159; See PMID 9701597; See PMID 11021657
An08g08850	Title: weak similarity to vegetative cell wall protein GP1 - Chlamydomonas reinhardtii
An08g08860	Title: weak similarity to period protein per -Drosophila sucinea
An08g08870	Remark: nrgA exhibited amino acid sequence similarity to bacterial hydroxylases and N-acetyltransferases. Null mutations introduced into nrgA and nrgBC resulted in mutant strains that exhibited wild-type-like symbiotic properties, including nitrogen fixation, when tested on soybean, cowpea, or mung bean host plants.; Similarity: to bacterial hydroxylases and N-acetyltransferases.; Title: similarity to NifA-regulated gene A NrgA -Bradyrhizobium japonicum; See PMID 10692350
An08g08890	Title: similarity to hypothetical protein Rv1619 -Mycobacterium tuberculosis
An08g08900	Title: weak similarity to farnesyl diphosphate synthase IspA from patent WO200056915-A1 - Streptococcus pneumoniae
An08g08910	Catalytic activity: sulfite + O2 + H2O = sulfate + H2O2.; Pathway: sulfur metabolism. Terminal reaction in the oxidative degradation of sulfur- containing amino acids. it uses cytochrome c as an electron acceptor.; Remark: the molybdenum-containing human enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Genetic deficiency of sulfite oxidase results in neurological abnormalities and often leads to death at an early age.; Similarity: with cytochrome B5 and nitrate reductase.; Title: strong similarity to mitochondrial sulfite oxidase SUOX - Homo sapiens; See PMID 7599189; See PMID 9428520; See PMID 9600976
An08g08920	Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Pathway: tryptophan metabolism; methane metabolism.; Remark: with a molecular mass of 54 kDa, CatC shows high similarity to other small-subunit monofunctional catalases and is most closely related to catalases from other fungi, Archaea, and animals. The catC gene displayed a relatively constant pattern of expression, not being induced by oxidative or other types of stress.; Similarity: belongs to the catalase family.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957
An08g08930	Title: similarity to hypothetical protein CAE41807.1 - Bordetella pertussis
An08g08940	Catalytic activity: a nitrile + H2O = a carboxylate + NH3.; Pathway: tryptophan metabolism; cyanoamino acid metabolism; nitrogen metabolism.; Remark: nitrilases (nitrile aminohydrolase, EC 3. 5. 5. 1) convert nitriles to carboxylic acids. The nitrilase genes encode very similar proteins that hydrolyze indole-3-acetonitrile to the phytohormone indole-3-acetic acid in vitro.; Similarity: belongs to the nitrilases.; Title: strong similarity to nitrilase NIT3 -Arabidopsis thaliana; See PMID 8022831; See PMID 9484465
An08g08950	Catalytic activity: choline sulfate + H2O = choline + sulfate.; Remark: a mutant deficient in choline dehydrogenase (CDH) activity, failed to oxidize [methyl-14C]choline to [methyl-14C]betaine, and did not use choline, but still used betaine, as an osmoprotectant.; Similarity: belongs to the animal sulfatase family.; Title: strong similarity to choline sulfatase betC -Sinorhizobium meliloti; See PMID 9141699
An08g08960	Title: weak similarity to protein fragment SEQ ID NO:56682 from patent EP1033405-A2 - Arabidopsis thaliana
An08g08980	Remark: the patent represents a novel polypeptide with hematopoietic cell regulatory activity and tissue forming/repairing activity.; Similarity: strong similarity to human putative SST-homologue patent WO200008056-A1 found in PATENTPROT:AAY80519.; Similarity: the ORF also shows strong similarity to some endosomal proteins with unknown function, like EMP70 of S. cerevisiae.; Title: strong similarity to protein from patent WO200008056-A1 - Homo sapiens
An08g09000	Remark: Dsk2p is a nuclear-enriched protein, and that Dsk2p assists in Cdc31 assembly into the new pindle pole body (SPB).; Title: strong similarity to ubiquitin like protein Dsk2 - Saccharomyces cerevisiae; See PMID 8682868
An08g09010	Remark: SAPs 49, 130, 145, and 155 are components of U2 snRNP-associated protein complex essential for spliceosome assembly named SF3b.; Remark: also strong similarity to Human secreted protein clone pm412_12 protein sequence SEQ ID NO:46 patent WO200009552-A1.; Title: strong similarity to spliceosomal protein SAP130 - Homo sapiens; See PMID 10490618
An08g09020	Gene-ID: gmdB; Remark: the enzyme acts probably on carbon-nitrogen bonds, other than peptide bonds In linear amides.; Similarity: belongs to the amidotransferase A subunit and related amidases.
An08g09030	Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: Chitinase has been suggested to play a pivotal role in autolysis of the parasitic cell wall of Coccidioides immitis during the asexual reproductive cycle (endosporulation) of this systemic pathogen. Loss of CTS1 function had no effect on virulence or endosporulation. The absence of a functional CTS1 gene can be compensated for by elevated expression of the CTS2 gene.; Similarity: belongs to the Streptomyces chitinase chi40 family.; Title: strong similarity to chitinase 1 cts1 -Coccidioides immitis; See PMID 8566773; See PMID 10992492
An08g09040	Title: similarity to hypothetical protein YNR069c -Saccharomyces cerevisiae
An08g09070	Remark: partial cds.
An08g09080	Similarity: N-terminal half show similarity to putative aminoacyl-transfer RNA synthetase PA4724 of P. aeruginosa.; Title: weak similarity to hypothetical aminoacyl-transfer RNA synthase PA4724 - Pseudomonas aeruginosa
An08g09090	Title: similarity to hypothetical protein B11E5.130 - Neurospora crassa
An08g09100	Title: weak similarity to hypothetical protein F9F8.20 - Arabidopsis thaliana
An08g09110	Title: similarity to hypothetical UDP-glucose,sterol transferase gstA - Aspergillus oryzae
An08g09120	Catalytic activity: UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Remark: C-terminal conserved region is sufficient and essential for enzyme activity, N-terminal residues are not required for in vitro glucosyltransferase activity.; Remark: similarity only to C-terminal region of C. albicans UDP-glucose:sterol glucosyltransferase.; Title: similarity to UDP-glucose:sterol glucosyltransferase UGT51C1 - Candida albicans
An08g09140	Catalytic activity: Hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Function: RhaA from A. aculeatus is able to hydrolyze alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105
An08g09150	Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Title: strong similarity to hypothetical glutathione S-transferase SPCC965.07c - Schizosaccharomyces pombe; See PMID 10720752
An08g09160	Title: strong similarity to hypothetical membrane protein YJL109c - Saccharomyces cerevisiae
An08g09170	Title: similarity to hypothetical protein SPBC20F10.05 - Schizosaccharomyces pombe
An08g09180	Function: esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An08g09190	Remark: a FAD containing protein.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Title: strong similarity to hypothetical monooxygenase moxY - Aspergillus parasiticus; See PMID 10855719
An08g09210	Catalytic activity: E. coli QueA catalyzes the synthesis of an epoxycyclopentane moiety and transfers this compound to specific tRNAs containing the queuosine precursor 7-(aminomethyl)-7-deazaguanine (preQ1).; Function: E. coli QueA catalyzes the penultimate step in the biosynthesis of the tRNA wobble nucleoside queuosine, a unique ribosyl transfer from the cofactor S-adenosylmethionine (AdoMet) to a modified-tRNA precursor.; Title: strong similarity to S-adenosylmethionine tRNA ribosyltransferase queA - Bacillus subtilis; See PMID 8347586; See PMID 10739928; See PMID 10810734
An08g09220	Function: NosA from Nostoc sp. is involved in activation of L-tyrosine and L-proline.; Similarity: the predicted A. niger protein shows similarity to several polyketide synthase genes.; Title: similarity to multifunctional peptide synthetase of the nostopeptolide biosynthetis NosD - Nostoc sp.
An08g09230	Catalytic activity: TRI11 of F. sporotrichioides catalyzes the hydroxylation at C-15 of isotrichodermin.; Function: TRI11 of F. sporotrichioides encodes a C-15 hydroxylase involved in trichothecene biosynthesis.; Pathway: TRI11 of F. sporotrichioides is a component of the trichothecene biosynthetic pathway.; Phenotype: disruption of TRI11 of F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: TRI11 of F. sporotrichioides belongs to the cytochrome P450 superfamily.; Remark: trichothecenes are sesquiterpendoid toxins,which inhibit protein biosynthesis.; Similarity: the ORF shows similarity to cytochrome P450 of many different species.; Title: strong similarity to isotrichodermin C-15 hydroxylase Tri11 - Fusarium sporotrichioides; See PMID 9435078
An08g09240	Similarity: the homology between the ORF and the hypothetical S. pombe protein extends over a large N-terminal region spanning about 400 amino acids.; Title: similarity to hypothetical transcription regulator SPAC139.03 - Schizosaccharomyces pombe
An08g09250	Remark: YBR180w is the systematic name for S. cerevisiae DTR1.; Remark: information regarding S. cerevisiae DTR1 has not yet been published and is available via http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: S. cerevisiae DTR1 belongs to the major facilitator family of transport proteins.; Title: similarity to dityrosine transporter Dtr1 -Saccharomyces cerevisiae
An08g09260	Catalytic activity: acetoacetyl-CoA synthetases catalyse the reaction, ATP + Acetoacetate + CoA = AMP + Pyrophosphate + Acetoacetyl-CoA.; Function: acetoacetyl-CoA synthetases are involved in multiple biochemical pathways.; Title: strong similarity to acetoacetyl-CoA synthase acsA - Sinorhizobium meliloti
An08g09280	Function: E. coli hpaG is a bifunctional decarboxylase/isomerase.; Function: E. coli hpaG is required for the utilisation of 3,4-hydroxy-phenylacetate.; Remark: the ORF is shorter than hpaG of E. coli (358 compared to 429 amino acids) and the two proteins show homology only over a N-terminal stretch of about 200 amino acids.; Title: similarity to 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomer hpaG -Escherichia coli; See PMID 8550403
An08g09290	Similarity: the predicted A. niger protein contains a central polysaccharide deacetylase domain.; Title: similarity to cellular protein hp5p15641_5211687_c2_29 from patent WO9737044-A1 -Helicobacter pylori
An08g09300	Title: similarity to prokaryotic essential protein #7529 from patent WO200277183-A2 - Burkholderia fungorum
An08g09310	Function: in A. nidulans amdA induces expression of the acetamidase, amdS.; Similarity: A. nidulans amdA contains two C2H2 zinc-finger motifs.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus
An08g09320	Function: S. cerevisiae Flr1 is a transmembrane transporter confering fluconazole resistance.; Induction: S. cerevisiae Flr1 is transcriptionally regulated by the Cap1 and yAP-1 proteins.; Remark: YBR008c is the systematic name for S. cerevisiae Flr1.; Similarity: S. cerevisiae Flr1 belongs to the major facilitator family (TC 2. A. 1).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926
An08g09330	Catalytic activity: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP(+) <=> (15Z)-12-oxophyto-10,15-dienoate + NADPH.; Function: opr of L. esculentum is a flavin mononucleotide (FMN)-dependent oxidoreductase in plants that belongs to the family of Old Yellow Enzyme (OYE).; Pathway: opr of L. esculentum is involved in the biosynthesis of the plant hormone jasmonic acid.; Title: strong similarity to 12-oxophytodienoate reductase opr - Lycopersicon esculentum; See PMID 11377202
An08g09340	Function: SOU1 is required for L-sorbose assimilation in Candida albicans.; Remark: C. albicans SOU1 belongs to the short-chain dehydrogenase/reductases family (SDR).; Title: strong similarity to short-chain dehydrogenase sou1 - Candida albicans
An08g09350	Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; plasma membrane; See PMID 10978525
An08g09360	Function: SOU2 is required for L-sorbose assimilation in Candida albicans.; Similarity: C. albicans SOU2 belongs to the short-chain dehydrogenase/reductases family (SDR).; Title: strong similarity to sorbitol utilization protein sou2 - Candida albicans
An08g09370	Function: S. cerevisiae Gal4 is a positive regulator of the galactose-inducible genes.; Similarity: S. cerevisiae Gal4 belongs to the family of fungal Zn(II)2Cys6 binuclear cluster DNA binding domain containing transcription factors.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 6366516; See PMID 7601342
An08g09380	Catalytic activity: xylitol dehydrogenases catalyzes the oxidation by NAD+ of xylitol to D-xylulose.; Function: xdh from G. mastotermitis catalyses the second step in the xylose utilising pathway converting xylose to xylulosephosphate.; Similarity: xdh from G. mastotermitis belongs to the superfamily of zinc containing, medium-chain alcohol dehydrogenases.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 10661867
An08g09390	Remark: frcK of S. meliloti is part of the ATP binding cassette fructose transporter operon.; Remark: the ORF shows also similarity to other hypothetical kinases.; Remark: the frc system is also a high-affinity transporter for ribose and mannose, which are both fructose competitors for the binding to the periplasmic FrcB protein.; Title: similarity to hypothetical kinase frcK -Sinorhizobium meliloti; See PMID 11466273
An08g09400	Title: weak similarity to hypothetical protein TP0491 - Treponema pallidum
An08g09410	Function: in S. cerevisiae overexpression of RTM1 confers resistance to the toxicity of molasses.; Remark: RTM loci are always physically associated with SUC telomeric loci.; Title: similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae
An08g09420	Remark: information regarding M. anisopliae 4MeS has not yet been published.; Title: strong similarity to protein 4MeS -Metarhizium anisopliae
An08g09430	Similarity: the N-terminus of the predicted A. niger protein contains a predicted transmembrane and a phoshorylase domain.; Similarity: the predicted A. niger protein contains several WD-40 repeats in its C-terminal half and shows similarity to multiple WD-40 containing proteins.; Title: similarity to notchless Nle - Drosophila melanogaster; See PMID 9857191
An08g09440	Catalytic activity: ATP + L-asparagine + tRNA(asn) = AMP + pyrophosphate + L-asparaginyl-tRNA(asn).; Remark: asparagine-tRNA ligases are also called asparaginyl-tRNA synthetases or asparagine translases.; Remark: the gene coding for NRSEC of E. coli is called asnS or tss.; Similarity: the ORF is much shorter than NRSEC of E. coli (198 compared to 466 amino acids).; Similarity: the ORF shows similarity to asparagyl-tRNA synthetases of various species.; Title: similarity to asparagine-tRNA ligase NRSEC -Escherichia coli; cytoplasm; See PMID 1425658; See PMID 2009959; See PMID 2693216
An08g09450	Function: 3-hydroxyacyl-CoA dehydrogenase is an enzyme involved in fatty acid metabolism, it catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA.; Similarity: the ORF is shorter than hbd of C. acetobutylicum.; Title: similarity to 3-hydroxybutyryl-CoA dehydrogenase hbd - Clostridium acetobutylicum; See PMID 8655474
An08g09460	Catalytic activity: nitrate reductases catalyse the reaction, NADH + nitrate <=> NAD(+) + nitrite + H(2)O.; Function: nitrate reductases are key enzymes in the assimilation of nitrate.; Title: strong similarity to nitrate reductase NIA1 -Arabidopsis thaliana; See PMID 9233539
An08g09470	Catalytic activity: cytochrome P450 proteins catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer.; Similarity: the ORF is longer than CYPF16 (634 compared to 524 amino acids), the homology between the two proteins spans more than 350 amino acids.; Similarity: the ORF shows similaritiy to many cytochrome P450 proteins.; Title: strong similarity to cytochrome P450 CYP4F16 - Mus musculus; See PMID 9501474; See PMID 11160642
An08g09490	Function: ctf1 alpha of F. solani is a DNA binding,transcription regulator.; Similarity: the predicted A. niger protein shows similarity to the Cys6Zn2 binuclear cluster of the Gal4 superfamily proteins.; Title: strong similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694
An08g09500	Remark: similarity is from C-terminus of predicted A. niger protein to central region of L. pealii kinesin,which is 300 aa shorter.; Title: similarity to kinesin light chain - Loligo pealei; cytoskeleton
An08g09510	Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows also strong similarity to domains of ankyrin.; Title: weak similarity to death associated protein kinase Dapk1 - Mus musculus
An08g09520	Function: ankyrins act as protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows similarity to repetitive domains of ankyrin.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021
An08g09530	Induction: spoVK/spoVJ from B. subtilis has an interesting pattern of regulation during sporulation because it is expressed from sequentially activated promoters, that are under the control of different sigma factors, sigma E and sigma K.; Remark: spoVK and spoVJ from B. subtilis are identical.; Remark: spoVK/spoVJ from B. subtilis is expressed only in the mother cell.; Similarity: the predicted A. niger protein shows similarity to spore formation protein spoVK from B. subtilis, which belongs to the CBXX/CFQX family.; Title: similarity to spore formation protein spoVK -Bacillus subtilis
An08g09540	Title: weak similarity to microtubule-based motor HsKIFC3 - Homo sapiens
An08g09550	Catalytic activity: a Phenol sulfate + H2O = a Phenol + Sulfate.; Function: ars-1 from N. crassa catalyzes the hydrolysis of Sulfate esters.; Regulation: N. crassa ars-1 belongs to a group of highly regulated sulfur-related structural genes that are expressed under conditions of sulfur limitation and are under coordinate control of the cys-3 and scon regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685
An08g09560	Remark: human early growth response protein 1 is a zinc-finger protein.; Title: similarity to early growth response protein 1 - Homo sapiens; nucleus; See PMID 9109500
An08g09570	Function: in rat MCT3 is the major MCT isoform responsible for efflux of glycolytically derived lactic acid from white skeletal muscle, however it is also able to import lactic acid.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638
An08g09580	Similarity: the ORF shows N-terminal similarity to the hypothetical protein of C. burnetii over a stretch of about 200 amino acids.; Title: strong similarity to hypothetical protein encoded by An14g06160 - Aspergillus niger
An08g09590	Title: similarity to secreted protein from patent WO9947540-A1 - Homo sapiens
An08g09600	Title: similarity to hypothetical protein BH3375 -Bacillus halodurans
An08g09610	Function: mutanase mutA of P. purporogenum exhibit strong binding to insoluble mutan.; Function: mutanases are alpha1,3-glucanases.; Remark: mutA of P. purporogenum is about 200 aminoacids longer at C-terminus.; Title: similarity to mutanase mutA - Penicillium purpurogenum; See PMID 10636904
An08g09620	Remark: the similarity to facB covers the N-terminal 280 amino acids.; Title: weak similarity to regulator protein of the lovastatin biosynthesis lovE - Aspergillus terreus
An08g09630	Remark: shows also similarity to several hypothetical prokaryontic transcriptional regulators.; Title: similarity to hypothetical protein SC5F2A.30 - Streptomyces coelicolor
An08g09640	Remark: might be a putative pseudogene.; Similarity: similarity is restricted to part of M. grisea protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea
An08g09650	Remark: shows similarity only to the N-terminal part of several dihydrodiol dehydrogenases, might be a putative pseudogene.; Title: weak similarity to dihydrodiol dehydrogenase phdE - Nocardioides sp. [putative pseudogene]
An08g09670	Remark: might be a putative pseudogene.; Similarity: show similarity to C-terminal part of several NADH dehydrogenases.; Title: weak similarity to subunit of NADH:ubiquinone reductase - Cyprinodon variegatus [putative sequencing error]; putative sequencing error
An08g09680	Catalytic activity: 2,4'-dihydroxyacetophenone dioxygenase catalyzes the conversion of 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate.; Function: 2,4'-dihydroxyacetophenone dioxygenase of Alcaligenes is involved in 4-hydroxyacetophenone degradation.; Title: strong similarity to 2,4-dihydroxyacetophenone dioxygenase dad - Alcaligenes sp.; See PMID 10567221
An08g09690	Title: weak similarity to secreted protein from patent WO9844113-A1 - Homo sapiens
An08g09700	Catalytic activity: aryl alcohol dehydrogenases catalyze the conversion of an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH.; Function: norsolorinic acid reductase norA of A. parasiticus is involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: shows also strong similarity to several aryl-alcohol dehyrogenases.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042
An08g09710	Similarity: shows similarity to several Sphingomonas enzymes involved in aromate catabolism.; Title: similarity to 2,2-dihydroxy-3,3-dimethoxy-5,5-dicarboxybiphenyl meta-cleavage compound hydrolase ligY -Sphingomonas paucimobilis; See PMID 9647824
An08g09720	Function: M. grisea Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Similarity: the M. grisea Pth11p is about 200 aminoacids longer at C-terminus.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An08g09750	Catalytic activity: alcohol dehydrogenases convert alcohol + NAD(+) to aldehyde or ketone + NADH.; Catalytic activity: it requires zinc as cofactor.; Title: strong similarity to alcohol dehydrogenase adh1p - Schizosaccharomyces pombe; cytoplasm; See PMID 6294096
An08g09760	Function: FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants.; Function: flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes.; Function: using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds.; Remark: putative frameshift at position 7783, one bp might be missing.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp. [putative frameshift]; putative frameshift; See PMID 10894733
An08g09770	Function: the carboxylesterase from B. linens is responsible for the conversion of 1,4-butanediol diacrylate to 4-hydroxybutyl acrylate.; Remark: putative frameshift at position 5478; one bp might be missing.; Similarity: shows also similarity to other esterases.; Title: strong similarity to 1,4-butanediol diacrylate esterase BDA1 - Brevibacterium linens [putative frameshift]; putative frameshift; See PMID 10361681
An08g09780	Title: weak similarity to hypothetical protein SC8F4.26 - Streptomyces coelicolor
An08g09800	Catalytic activity: tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Remark: tannin acyl hydrolase is an alternativ name for tannase.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102
An08g09830	Title: similarity to hypothetical protein encoded by An02g10630 - Aspergillus niger
An08g09840	Title: strong similarity to cysteine proteinase polypeptide from patent WO200268623-A2 - Aspergillus niger
An08g09850	Catalytic activity: acid phosphatases also catalyse transphosphorylations.; Catalytic activity: acid phosphatases catalize the reaktion of orthophosphoric monoester + H(2)O = an alcohol + phosphate.; Remark: acid phosphatases show a wide specificity.; Title: strong similarity to phosphate-repressible acid phosphatase precursor phoA - Penicillium chrysogenum; See PMID 1563629
An08g09860	Title: similarity to protein SEQ ID NO:53564 from patent EP1033405-A2 - Arabidopsis thaliana
An08g09870	Pathway: CmcJ catalyzes late reaction in the cephamycin biosynthetic pathway.; Similarity: the ORF encoded protein also shows similarity to C-7 hydroxycephem methyltransferase coupling protein from patent R92153.; Title: similarity to methyltransferase CmcJ -Streptomyces clavuligerus; See PMID 9696752
An08g09880	Title: weak similarity to hydrophobin CoH1 -Coprinus cinereus
An08g09900	Title: similarity to hypothetical protein encoded by An08g01250 - Aspergillus niger
An08g09910	Title: weak similarity to hypothetical protein MMJ24.4 - Arabidopsis thaliana
An08g09920	Catalytic activity: scytalone dehydratases catalize the reaction of Scytalone <=> 1,3,8-trihydroxynaphthalene + H(2)O.; Function: pathogenic fungi use melanin in the penetration of host plants.; Pathway: scytalone dehydratases are involved in the biosynthesis of melanin in pathogenic fungi.; Title: strong similarity to scytalone dehydratase -Pyricularia oryzae; See PMID 9571787
An08g09930	Remark: the ORF encoded protein is N-terminally truncated due to the contig border. .; Title: weak similarity to hypothetical protein encoded by An11g05870 - Aspergillus niger [truncated ORF]
An08g09940	Function: involved in trichothecene biosynthesis in Fusarium sporotrichioides.; Remark: TRI11 of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase.; Remark: trichothecenes are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 8246841
An08g09950	Function: profilin controlls actin polymerisability.; Remark: significant blast hits are only found in the SCOP database.; Title: weak similarity to profilin 1 - Arabidopsis thaliana; See PMID 2257632
An08g09960	Remark: Raf-1 kinase of Xenopus laevis is a potential regulator of intracellular pH in oocytes.; Similarity: the ORF is about half as long as the Raf-1 kinase of X. laevis (299 compared to 638 amino acids). Only 120 amino acids are encompassed by the alignment between the two molecules.; Title: similarity to protein kinase raf-1 - Xenopus laevis; See PMID 9923073
An08g09970	Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Similarity: the c-terminal part of the ORF encoded protein shows weak similarity to the human myosin heavy chain MYH8.; Title: similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 7557402
An08g09980	Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O <=> UDP-glucuronate + 2 NADH.; Pathway: the UDPGDH product from D. melanogaster is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.; Remark: alternate names for UDP-glucose dehydrogenase UDPGDH from D. melanogaster: sugarless or sgl.; Title: strong similarity to UDP-glucose dehydrogenase UDPGDH - Drosophila melanogaster; See PMID 9862465
An08g09990	Pathway: the CapB enzyme from S. pneumoniae is involved in the production of the type 3 pneumococcal capsule, which is composed of cellobiuronic acid units connected in a beta (1-->3) linkage.; Title: similarity to synthase of the type 3 pneumococcal capsular polysaccharide CapB - Streptococcus pneumoniae; See PMID 9109098
An08g10000	Complex: the human cytochrome b245 beta chain CYBB forms a complex with the alpha chain CYBA.; Function: the human CYBB gene product is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H+ currents of restingphagocytes. It also participates in the regulation of cellular pH and is blocked by zinc.; Localization: the human CYBB gene product is a integral membrane protein.; Remark: a putative sequencing error results in an frameshift.; Remark: chronic granulomatous disease (CGD) is a rare inherited disorder associated with a profound predisposition to infection due to the lack of a microbicidal oxidase system in the phagocytes of these patients. This disorder is characterized by the absence of functional plasma-membrane-associated NADPH oxidase due to a defect in human beta-chain of cytochrome b-245) protein (X-CGD or CYBB gene).; Title: strong similarity to cytochrome b245 beta chain CYBB - Homo sapiens [putative frameshift]; putative frameshift; See PMID 10578014; See PMID 3600768; See PMID 3600769
An08g10020	Function: In the DNA of higher eukaryotes,hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of g/t mismatches. The human TDG enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs i the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.; Remark: for the mouse TDG interaction to DNA-binding transciption factors (etc. c-Jun, RAR) could be shown.; Similarity: the ORF encoded protein shows stronger similarity to the mouse TDG homologue, but this enzyme is not as well characterized as the human TDG.; Title: strong similarity to G/T mismatch-specific thymine-DNA glycosylase TDG - Homo sapiens; nucleus; See PMID 9144158; See PMID 8407958
An08g10030	Title: strong similarity to hypothetical MF-7 antigenic protein from patent WO9721817-A1 - Malassezia sp.
An08g10040	Function: the mouse vav-oncogene is probable exchange factor for a small Ras-like GTP-binding protein. It can be activated by truncation of the n-terminus.; Title: similarity to GTP/GDP exchange factor and proto-oncogene vav - Mus musculus; See PMID 9058837; See PMID 1565462
An08g10050	Complex: the rat Bridge (Bridge-1) protein interacts with E2A family of basic helix-loop-helix transcription factors (e. g. E12/E47 proteins).; Function: Bridge-1 from rat, by utilizing its PDZ-like domain to interact with E12, may provide a new mechanism for the coactivation and regulation of transcription of the insulin gene.; Similarity: the Bridge-1 protein from Rattus norvegicus also shows similarity to the proteasome subunit p27.; Title: strong similarity to transactivating protein BRIDGE - Rattus norvegicus; See PMID 10567574
An08g10060	Function: the Gsp1 (CaGsp1) protein from Candida albicans is a GTP-binding protein involved in nucleocytoplasmic transport. It is required for the import of protein into the nucleus and also for RNA export.; Remark: the C. albicans CaGSP1 gene is able to complement a gsp1 S. cerevisiae mutant.; Similarity: the C. albicans CaGsp1 protein and the S. cerevisiae Gsp1/Gsp2 proteins belong to the Ran family in the Ras superfamily.; Similarity: the ORF encoded protein shows also strong similarity to Gsp1 from S. cerevisiae, which is much better characterized.; Title: strong similarity to small G-protein Gsp1 -Candida albicans; See PMID 10854789
An08g10070	Function: the S. cerevisae Rad16 protein involved in differential repair of DNA after UV damage. It will repair preferentially the MAT-alpha locus compaired with the HML-alpha locus.; Remark: N-terminal truncated ORF due to the end of contig.; Title: strong similarity to DNA repair protein Rad16 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 8910442; See PMID 1508678; See PMID 7553931
An08g10080	Remark: the similarity is only to a short domain of the MHC class III protein.; Title: weak similarity to MHC class III histocompatibility antigen HLA-B-associated transcript BAT2 - Homo sapiens; See PMID 2156268
An08g10100	Remark: Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis that allows the suppression of reduction or dehydration reactions at specific biosynthetic steps.; Title: strong similarity to cytochrome P450 monooxygenase lovA - Aspergillus terreus; See PMID 10334994
An08g10110	Remark: the POX18 protein in c. tropicalis is one of the oleate-inducible peroxisomal proteins.; Remark: the PXP-18 has a role in the beta-oxidation of long-chain fatty acids.; Remark: the protein shows strong similarity to sterol carrier protein from different eukaryotes.; Title: strong similarity to lipid transfer protein POX18 - Candida tropicalis; See PMID 2364939; See PMID 2470648
An08g10130	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: blastp results correspond to serine,threonine and proline rich regions.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611
An08g10140	Remark: the L31 protein is known in many different organisms.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L31 - Saccharomyces cerevisiae; cytoplasm; See PMID 10588049; See PMID 2666132; See PMID 6355773
An08g10150	Catalytic activity: a Nitrile + H2O = a Carboxylate + NH3.; Pathway: Tryptophan metabolism; Cyanoamino acid metabolism; Nitrogen metabolism.; Remark: Acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Remark: Fhit occurs in a fusion protein, NitFhit, in D. melanogaster and C. elegans although FHIT and NIT1 are separate genes in mammalian cells.; Remark: the human and mouse NIT1 genes are members of an uncharacterized mammalian gene family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia.; Title: strong similarity to nitrilase Nit1 - Mus musculus; See PMID 9671749; See PMID 10959838
An08g10160	Similarity: blastp matches are mainly based on repetetive structures.
An08g10170	Remark: Patentno: R87508.; Remark: Synthetic jojoba fatty acyl reductase gene having reduced AT content used in the production of wax ester in plant cells not naturally producing wax ester.; Title: weak similarity to fatty-acyl-reductase from patent WO9533055-A2 - Brassica sp.
An08g10190	Title: weak similarity to hypothetical protein VeA -Neurospora crassa
An08g10210	Remark: also weak similarity to other transcriptional regulators in different organisms.; Title: weak similarity to suppressor protein SEF1 -Kluyveromyces lactis
An08g10220	Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1).; Remark: catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template.; Remark: in plants, retrotransposons have been described in maize, Arabidopsis and wheat, and non-viral retroposons in maize.; Remark: transcription and transposition of Tto1 were observed in rice cells.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; See PMID 2536143
An08g10260	Remark: RTM loci are always physically associated with SUC telomeric loci. The SUC-RTM sequences are located between X and Y' subtelomeric sequences at chromosome ends.; Remark: RTM1 in S. cerevisiae confers resistance to the toxicity of molasses.; Remark: The particular subtelomeric position might explain the SUC-RTM sequence amplification observed in the genome of yeasts used in industrial biomass or ethanol production with molasses as substrate.; Remark: the protein shows also similarity to 7-aminocholesterol resistance protein RTA1 - S. cerevisiae.; Title: similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 9211787; See PMID 7672593
An08g10270	Remark: the S. cerevisae SPO72 diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate; these phenotypes are recessive.; Title: similarity to hypothetical sporulation required protein Spo72 - Saccharomyces cerevisiae; See PMID 10029994
An08g10280	Remark: IDGF, stimulated the proliferation of NIH-Sape-4 cells in an autocrine manner.; Remark: similarity to different adenosine deaminases.; Remark: similarity was found between this factor and atrial gland granule-specific antigen of Aplysia californica.; Title: strong similarity to secretory component IDGF - Sarcophaga peregrina; See PMID 8662793
An08g10300	Remark: functionally, cNT1 exhibited the transport characteristics of the nucleoside transport system cit (selective for pyrimidine nucleosides and adenosine) and accepted both 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) as permeants (Km = 0. 49 and 0. 51 mM, respectively).; Title: strong similarity to concentrative Na+-nucleoside cotransporter cNT1 - Rattus norvegicus; See PMID 10455109; See PMID 8027026
An08g10310	Catalytic activity: ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate + Protein N-ubiquityllysine.; Remark: UBC11 is the S. cerevisiae gene that is most similar in sequence to E2-C, a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Title: strong similarity to ubiquitin conjugating enzyme Ubc11 - Saccharomyces cerevisiae; See PMID 9675819; See PMID 10762014
An08g10320	Function: fission yeast chk1 protein kinase is involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present. it controls phosphorylation and abundance of pds1 to prevent anaphase entry and also helps prevent mitotic exit.; Remark: coupling of the checkpoint pathways that monitor DNA repair and replication to the control of the cell cycle is essential.; Similarity: the predicted A. niger protein shows strong similarity to checkpoint protein kinase chk1 from S. pombe and from many other eucaryotic species.; Title: strong similarity to checkpoint protein kinase chk1p - Schizosaccharomyces pombe; See PMID 8497322; See PMID 10679396
An08g10330	Title: weak similarity to hepatoma-derived growth factor-related protein HRP-2 - Mus musculus; See PMID 929944
An08g10340	Catalytic activity: GTP + 3 H2O = Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidin e + Pyrophosphate.; Pathway: riboflavin biosynthesis pathway.; Remark: GTP-cyclohydrolase II forms 2,5-diamino-4-oxo-6-(5'-phosphoribosyl)-amino pyrimidine, a possible intermediate in the biosynthesis of riboflavin.; Remark: GTP-cyclohydrolases catalyse the removal of C-8 atom from GTP as formic acid.; Title: strong similarity to 3,4-dihydroxy-2-butanone 4-phosphate synthase Rib3 - Saccharomyces cerevisiae; See PMID 394766; See PMID 3891906
An08g10350	Remark: components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes.; Title: strong similarity to beta subunit of transcription initiation factor TFIIE Tfa2 - Saccharomyces cerevisiae; nucleus; See PMID 9545282; See PMID 9845373; See PMID 7961670
An08g10360	Remark: the human TPR protein seems a general constituent of the intranuclear filaments attached to the nucleoplasmic annulus of the nuclear pore complex (NPC) in diverse kinds of vertebrate cells.; Title: strong similarity to nuclear pore complex associated protein TPR - Homo sapiens; See PMID 9024684; See PMID 10827939
An08g10370	Title: similarity to hypothetical protein SPBP8B7.31 - Schizosaccharomyces pombe
An08g10380	Title: weak similarity to retinitis pigmentosa GTPase regulator-like protein RPGR - Takifugu rubripes; See PMID 10932196
An08g10390	Remark: N-terminal truncated orf due to end of contig.; Remark: the protein seems approximately 200 aa to short.; Remark: these helicases have low-specificityand are zinc-dependent; in vitro they show dna-binding.; Title: strong similarity to DNA/RNA helicase Hfm1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 8972578
An08g10400	Remark: SpUGT S. pombe was expressed in the Golgi membranes of UDP-galactose transporter-deficient Lec8 cells, and complemented the genetic defect of the mutant cells.; Similarity: belongs to the UDP-galactose transporter.; Title: strong similarity to UDP-galactose transport protein SpUGT - Schizosaccharomyces pombe
An08g10410	Remark: the protein shows similarity to proteins with different functions and length due to repetitiv sequences.; Title: weak similarity to hypothetical RNA binding protein - Homo sapiens
An08g10440	Remark: in yeast, HOP1 and RED1 are required during meiosis for proper chromosome segregation and the consequent formation of viable spores. HOP1 is associated with the lateral elements of the SC.; Remark: the synaptonemal complex (SC) is a meiosis-specific proteinaceous structure that holds homologous chromosomes close together along their length during the pachytene stage of meiotic prophase. The SC is observed in sexually reproducing fungi, plants and animals and is highly conserved at the cytological level.; Title: similarity to meiosis-specific protein HOP1 -Kluyveromyces lactis; See PMID 10855495; See PMID 10958662
An08g10450	Remark: Sud1 of fission yeast itself is associated with the ubiquitin pathway in fission yeast and binds to Cdc18 in vivo.; Remark: alternative names sud1.; Remark: in the fission yeast Schizosaccharomyces pombe, S phase is limited to a single round per cell cycle through cyclin-dependent kinase phosphorylation of critical replication factors. evolutionary conservation of the Sud1/CDC4 pathway suggests that phosphorylation-coupled proteolysis may be a general feature of nearly all eukaryotic cell cycles.; Title: similarity to F-box/WD-repeat protein op2p -Schizosaccharomyces pombe; See PMID 9653157
An08g10460	Remark: YsxC is a member of a family of GTP-binding proteins carried by a diverse range of organisms from bacteria to yeasts, plants, and humans.; Remark: there is also similarity to Aquifex aeolicus yihA family member polypeptide sequence patent WO9954474-A2.; Similarity: to translation elongation factor Tu.; Title: similarity to GTP-binding protein ysxC -Bacillus subtilis; See PMID 11073929
An08g10470	Remark: eukaryotic vesicular transport requires the recognition of membranes through specific protein complexes.; Similarity: belongs to the adaptor complexes small subunits family.; Title: strong similarity to clathrin coat assembly protein CLAPS3 - Homo sapiens; See PMID 8697810; See PMID 10229581
An08g10480	Remark: L7a is the third largest protein in the 60s subunit.; Similarity: belongs to the l7ae family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L7 - Schizosaccharomyces pombe; cytoplasm; See PMID 9565672; See PMID 11130464
An08g10490	Remark: shows also similarity to tumor overexpressed protein TOG from Homo sapiens and similar genes from higher eukaryotes which are about the double in size.; Remark: the tagged p93dis1 S. pombe in living cells localizes along cytoplasmic microtubule arrays in interphase and the elongating anaphase spindle in mitosis,but association with the short metaphase spindle microtubules is strikingly reduced. In the spindle, the tagged p93dis1 is enriched at the spindle pole bodies (SPBs).; Title: strong similarity to spindle pole body-associated protein dis1p - Schizosaccharomyces pombe; See PMID 7628693
An08g10500	Title: strong similarity to hypothetical protein EAA62682.1 - Aspergillus nidulans
An08g10510	Catalytic activity: UDPglucose + D-glucose 6-phosphate = UDP + alpha,alpha'-trehalose 6-phosphate.; Gene-ID: tpsA;tps1; Pathway: starch and sucrose metabolism.; Remark: disruption of tpsA only weakly reduces growth on glucose, and neither influences the glucose induction of a low affinity glucose permease nor interferes with the catabolite repression of a pectinase; it causes reduced heat tolerance of conidia.; Remark: strong similarity to Aspergillus niger trehalose synthase patent WO9824882-A1.; Remark: the difference in the sequences is caused by strain variations or sequencing errors.; Similarity: to other fungal tps1 and to an E. coli enzyme (gene otsa).; cytoplasm; See PMID 9006911; See PMID 11152943
An08g10520	Remark: putative hydrolase with unknown specificity.; Remark: strong similarity to human prostate tumor EST fragment derived protein #67 patent DE19820190-A1.; Title: strong similarity to human prostate tumor EST fragment derived protein #67 from patent DE19820190-A1 -Homo sapiens
An08g10530	Catalytic activity: citrate = isocitrate.; Pathway: citrate cycle (TCA cycle); glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) forms. the active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Remark: an iron-sulfur protein. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts isocitrate into cis-aconitate.; Similarity: belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545
An08g10540	Title: similarity to hypothetical protein CAD60750.1 - Podospora anserina
An08g10550	Remark: the human carnitine/acylcarnitine translocase (CACT) transports acylcarnitines into mitochondria in exchange for free carnitine and it is,therefore, essential for the fatty acid beta-oxidation pathway.; Title: strong similarity to carnitine/acylcarnitine translocase CACT - Homo sapiens; See PMID 9837782
An08g10560	Remark: characterization of the Neurospora crassa mus-25 mutant suggests that it is defective in recombination repair and belongs to the uvs-6 epistasis group. It shows a high sensitivity to the alkylating agents methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not to UV radiation.; Remark: the prdicted ORF shows also strong similarity to human RAD54 N-terminal peptide patent EP844305-A2.; Similarity: belongs to the snf2/rad54 helicase family.; Title: strong similarity to Rad54 homolog mus-25 -Neurospora crassa; See PMID 11016845
An08g10570	Title: strong similarity to hypothetical membrane protein YLR386w - Saccharomyces cerevisiae
An08g10600	Remark: Yeast cells lacking a functional ATM1 gene have an unstable mitochondrial genome and have white mitochondria that completely lack cytochromes. Atm1p is the first mitochondrial member of the ABC family to be identified and the only eukaryotic ABC transporter that has been shown to be necessary for normal cellular growth.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters). MDR subfamily.; Title: strong similarity to ABC transporter Atm1 -Saccharomyces cerevisiae; See PMID 7828591; See PMID 9428742
An08g10610	Title: strong similarity to hypothetical protein EAA59931.1 - Aspergillus nidulans
An08g10640	Remark: Xkid is responsible for the polar ejection forces acting on chromosome arms.; Remark: microtubule-associated motor proteins are thought to be involved in spindle formation and chromosome movements in mitosis/meiosis.; Title: strong similarity to kinesin-like DNA binding protein Xkid - Xenopus laevis; See PMID 8599929; See PMID 10966105
An08g10650	Remark: COPII is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex and sar1.; Remark: component of the COPII coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory,plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.; Similarity: belongs to the sec23/sec24 family. sec24 subfamily.; Title: strong similarity to transport protein Sec24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 10712514; See PMID 10753972
An08g10670	Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: MAP kinases have been established to be key regulators of cellular signal transduction systems and are conserved from baker's yeast to human beings.; Similarity: belongs to the serine/threonine protein kinase family.; Title: strong similarity to mitogen-activated protein kinase FsMAPK - Fusarium solani; deleted EC_number 2.7.1.37; See PMID 9305760; See PMID 10600495
An08g10680	Catalytic activity: hydroxymethylbilane = uroporphyrinogen III + H2O.; Pathway: porphyrin and chlorophyll metabolism; fourth step in porphyrin biosynthesis by the shemin pathway. involved in heme biosynthesis.; Remark: a hem4 delta disruption mutation was constructed which had phenotypes identical to the cyt mutation. Biochemical analysis confirmed the absence of uroporphyrinogen III synthase activity in both hem4 delta and cyt mutant strains.; Similarity: to uroporphyrinogen-III synthase from different organisms.; Title: similarity to uroporphyrinogen-III synthase Hem4 - Saccharomyces cerevisiae; See PMID 2834088; See PMID 7597845
An08g10690	Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Phenotype: the mutant complex lacking the 40 kD subunit is not capable of reducing ubiquinone.; Title: strong similarity to 40 kD subunit of NADH-ubiquinone reductase NUO-40 - Neurospora crassa; localisation:mitochondrion; See PMID 10497022; See PMID 1825202
An08g10700	Title: similarity to hypothetical methyltransferase - Schizosaccharomyces pombe
An08g10710	Function: the S. cerevisiae homolog Rpn9p is subunit of the 19S proteasome regulatory particle.; Similarity: strong similarity to Human 26S proteasome sequence patent JP11032774-A, and same sequence Human secreted protein clone yj29_1 protein sequence SEQ ID NO:80 patent WO9958642-A2.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn9 - Saccharomyces cerevisiae
An08g10720	Remark: Gaa1p S. cerevisiae is required for a terminal step of GPI anchor attachment and could be part of the putative GPI:protein transamidase.; Remark: alternative names are Gaa1p, YLR088w.; Remark: anchoring of proteins to membranes by glycosylphosphatidylinositols (GPIs) is ubiquitous among all eukaryotes and heavily used by parasitic protozoa. GPI is synthesized and transferred en bloc to form GPI-anchored proteins. The key enzyme in this process is a putative GPI:protein transamidase that would cleave a peptide bond near the COOH terminus of the protein and attach the GPI by an amide linkage.; Title: strong similarity to glycosylphosphatidylinositol anchor attachment protein End2 - Saccharomyces cerevisiae; See PMID 7730400
An08g10730	Title: similarity to hypothetical protein SPAC19B12.06c - Schizosaccharomyces pombe
An08g10740	Function: the ZmGnsN3 glucanase of Z. may is e. g. believed to be useful as hydrolase in cell wall elongation or expansion for plant defense against pathogens and stress.; Similarity: the ORF shows strong similarity to the hypothetical protein YAL049c of S. cerevisiae.; Title: strong similarity to ZmGnsN3 glucanase from patent WO200073470-A2 - Zea mays
An08g10750	Remark: SPBC3B8. 06 of S. pombe is possibly involved in RNA binding and is similar to the probable membrane protein YCR062w of S. cerevisiae, which is only 120 amino acids long.; Similarity: the ORF overlaps with A. niger ESTs an_2557 (EMBLEST:BE759690), an_2482 (EMBLEST:BE759628) and an_1914 (EMBLEST:BE760577).; Similarity: the predicted ORF is 143 amino acids longer at its N-terminus than SPBC3B8. 06 of S. pombe.; Title: strong similarity to hypothetical protein SPBC3B8.06 - Schizosaccharomyces pombe
An08g10760	Function: autotransporters are implicated as important or putative virulence factors in many Gram-negative pathogens.; Similarity: the ORF shows similarity to ice nucleation proteins from some bacteria, which is necessary to stimulate ice growth at temperatures below 0 degrees.; Title: similarity to hypothetical autotransporter protein yapE - Yersinia pestis; See PMID 8224607; See PMID 9778731
An08g10770	Title: strong similarity to hypothetical protein CAD70330.1 - Neurospora crassa
An08g10780	Similarity: the predicted ORF is 66 amino acids shorter than the hypothetical protein T16K5. 230 of A. thaliana.; Title: strong similarity to hypothetical protein T16K5.230 - Arabidopsis thaliana
An08g10790	Function: hol1 S. cerevisiae is involved in the uptake of histidinol, the biosynthetic precursor to histidine and of several cations.; Phenotype: additional hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Remark: hol1 is also called YNR055C or N3494 and belongs to the major facilitator family (drug resistance translocase family).; Similarity: the ORF shows similarity to several major facilitator family multi-drug resistance proteins from different species and with various substrate specificities.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402; See PMID 2405251
An08g10800	Catalytic activity: lox of N. crassa converts an L-amino acid + H(2)O + O(2) <=> a 2-oxo acid + NH(3) + H(2)O(2).; Function: in lower eukaryotes such as aspergillus the main role of amine oxidases is to provide a source of ammonium.; Induction: the addition of D-phenylalanine to starved cultures of N. crassa leads to de novo synthesis of L-amino-acid oxidase.; Remark: lox of N. crassa is also called lao.; Title: strong similarity to L-amino-acid oxidase lox - Neurospora crassa; See PMID 2145270
An08g10810	Similarity: only the N-terminal region of the ORF shows similarity to some hypothetical proteins.; Similarity: the ORF is 278 amino acids longer than LRP16 of H. sapiens.; Title: strong similarity to hypothetical low density lipoprotein LRP16 - Homo sapiens
An08g10820	Catalytic activity: NAD(+)-dependent aldehyde dehydrogenases convert an aldehyde + NAD(+) + H(2)O <=> an acid + NADH.; Function: iad1 of U. maydis converts indole-3-acetaldehyde to indole-3-acetic acid in the presence of NAD(+).; Induction: expression of iad1 from U. maydis was strongly induced during growth on ethanol while under these conditions iad1-null mutants were unable to grow.; Phenotype: the ability of iad1 from U. maydis to convert IndCH2CH2O to IndCH2COOH was at least 100-fold reduced in iad1-null mutants grown in medium with glucose as carbon source.; Similarity: the ORF shows similarity to NAD(+)-dependent aldehyde dehydrogenases, which are involved in diverse metabolic pathways.; Title: strong similarity to indole-3-acetaldehyde dehydrogenase iad1 - Ustilago maydis
An08g10830	Catalytic activity: dimethylallyltransferases (EC 2. 5. 1. 1) convert dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: geranylgeranyl pyrophosphate synthases convert trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Catalytic activity: geranyltranstransferases (EC 2. 5. 1. 10) convert geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Function: geranylgeranyl diphosphate synthase is a key enzyme in isoprenoid biosynthesis.; Function: ggpps of G. fujikuroi has three catalytic activities, of EC 2. 5. 1. 29, EC 2. 5. 1. 1 and EC 2. 5. 1. 10.; Remark: ggpps of G. fujikuroi is also called ggs.; Similarity: the ORF is 129 amino acids longer at its N-terminus than ggpps of G. fujikuroi and is also longer than other geranylgeranyl pyrophosphate synthase homologues from different species.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Gibberella fujikuroi; See PMID 9230902
An08g10860	Catalytic activity: fatty acid synthases convert acetyl-CoA + N malonyl-CoA + 2N NADPH <=> a long-chain fatty acid + (N+1) CoA + N CO(2) + 2N NADP(+).; Catalytic activity: fatty-acyl-CoA synthases convert acetyl-CoA + N malonyl-CoA + 2 NADH + 2 NADPH <=> a long-chain acyl-CoA + N CoA + N CO(2) + N NAD(+) + N NADP(+).; Similarity: the ORF also shows strong similarity to fatty-acyl-CoA synthase (EC 2. 3. 1. 86) beta chain from yeast species.; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans
An08g10870	Function: prpD of S. typhimurium is involved in propionate catabolism, an operon is constituted by the prpBCDE genes.; Remark: in contrast to prpD of S. typhimurium no membrane localization is predicted for the ORF.; Title: strong similarity to 2-methylcitrate dehydratase PrpD - Salmonella typhimurium; See PMID 9006051
An08g10880	Function: lovastatin biosynthesis gene cluster ORF13 of A. terreus is a putative transcription regulator involved in the biosynthesis of polyketides, ubiquitous products of secondary metabolism in microorganisms.; Similarity: the ORF shows similarity to several transcriptional regulators from different species.; Title: strong similarity to regulator protein of lovastatin biosynthesis gene cluster encoded by ORF13 -Aspergillus terreus; See PMID 10334994
An08g10890	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 110 amino acids.; Title: questionable ORF
An08g10910	Remark: the predicted ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An08g10920	Catalytic activity: citrate synthase YKPSCA of P. aeruginosa catalyses the reaction citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: citrate synthase is the enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation.; Induction: the activity of citrate synthase YKPSCA from P. aeruginosa is allosteric regulated by NADH.; Similarity: the predicted ORF shows similarity to citrate synthases from several species.; Title: strong similarity to citrate synthase YKPSCA - Pseudomonas aeruginosa
An08g10930	Catalytic activity: fatty-acid synthases convert acetyl-CoA + N-malonyl-CoA + 2N NADPH = long chain fatty-acid + (N+1)CoA + N CO(2) + 2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Remark: fas2 of S. cerevisiae is a multifunctional enzyme with fatty-acyl-CoA synthase,3-oxoacyl-[acyl-carrier protein] reductase and 3-oxoacyl-[acyl-carrier protein] synthase activity.; Remark: fas2 of S. cerevisiae is also called YPL231w.; Similarity: the predicted ORF shows similarity to fatty-acid synthases from several species.; Title: strong similarity to fatty acid synthase alpha subunit Fas2 - Saccharomyces cerevisiae; See PMID 8962148
An08g10940	Function: nrgA (nifA-regulated gene) of B. japonicum is probably involved in nitrogen fixation under anaerobic conditions.; Induction: nrgA (nifA-regulated gene) of B. japonicum is controlled by the transcriptional regulatory protein nifA.; Title: weak similarity to hypothetical N-acetyltransferase nrgA - Bradyrhizobium japonicum; See PMID 10692350
An08g10970	Function: flr1 of S. cerevisiae is a multi-drug resistance transporter conferring resistance to several fungicide drugs, e. g. benomyl.; Induction: the expression of flr1 in S. cerevisiae in drug-treated cells is under the control of the transcriptional regulators pdr3p and yap1.; Remark: a splice site was detected upstream of the START codon.; Remark: flr1 of S. cerevisiae is also called YBR008C or YBR0120.; Similarity: the predicted ORF shows similarity to several transporters but also to PATENTPROT:W14439, a protein involved in cephalosporin C biosynthesis.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10102370; See PMID 10572257; See PMID 11056165
An08g10980	Function: the facB gene of Aspergillus nidulans encodes a DNA binding transcriptional activator required for growth on acetate as sole carbon source.; Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Remark: facB of A. nidulans is analogous to the A. niger acuB gene.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 10483720
An08g10990	Catalytic activity: dienelactone hydrolases convert 4-carboxymethylenebut-2-en-4-olide + H(2)O <=> 4 oxohex-2-enedioate.; Function: dienelactone hydrolases are involved in phenylalanine metabolism and 1,4-dichlorobenzene degradation by facilitating the ring cleavage of the cyclic ester.; Remark: dienelactone hydrolases are also called carboxymethylenebutenolidases or maleylacetate enol-lactonases.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST BE759260, EMBLEST:BE759445, EMBLEST:BE759443,EMBLEST:BE759448 and EMBLEST:BE759416.; Similarity: the predicted ORF shows homology to dienelactone hydrolases from several species.; Title: similarity to dienelactone hydrolase clcD -Rhodococcus opacus; See PMID 8497485; See PMID 9495745
An08g11000	Similarity: the predicted ORF shows similarity to the A. niger xlnR gene (T50875), which encodes the regulator of the xylanolytic pathway (PATENTPROT:W08586).; Similarity: the predicted ORF shows similarity to the DNA binding domain of several GAL4-type zinc cluster proteins.
An08g11010	Title: similarity to hypothetical protein encoded by An12g05730 - Aspergillus niger
An08g11030	Catalytic activity: acid phosphatases convert an orthophosphoric monoester + H(2)O <=> an alcohol + phosphate.; Catalytic activity: phytases convert myo-inositol hexakisphosphate + H(2)O <=> D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate.; Function: acid phosphatases in A. niger are involved in the autolysis of mycelia by phosphatase activities as well as intracellular reactions, e. g. the riboflavin metabolism/inositol phosphate metabolism.; Gene-ID: phyB;aph; Remark: A. awamori strains carry several copies of acid phosphatase genes demonstrating the importance for elevated enzyme activities.; Similarity: 14 to 15 amino acids of the predicted ORF differ from the published sequences of the A. niger proteins phyB and aph.; Similarity: the ORF shares strong homologies with EMBL entries EMBL:ANPHYB (A. niger phytase (phyB) gene) and EMBL:AN25AP (A. niger var awamori pH 2. 5 optimum acid phosphatase (aph) gene).; Similarity: the predicted ORF shows strong similarity to entries in the patent database PATENTPROT:R46235 and PATENTPROT:R46791 as well as PATENTDNA:Q58121 and PATENTDNA:Q56945, which concern A. niger pH 2. 5 acid phosphatase.; See PMID 8224894; See PMID 8865587; See PMID 10329192
An08g11040	Complex: the interaction of ZPR1 with eEF-1alpha contributes to normal cellular proliferation.; Function: loss of ZPR1 in S. pombe causes disruption of nucleolar function, including preribosomal RNA expression.; Localization: the zinc finger protein ZPR1 of different organisms translocates from the cytoplasm to the nucleus after treatment of cells with mitogens, and accumulates in the nucleolus of proliferating cells.; Phenotype: ZPR1 of different organisms is essential for cell viability.; Similarity: A. niger EST EMBLEST:BE758797 contains exon1 and part of exon 2 of the predicted gene.; Title: strong similarity to zinc-finger protein zpr1p - Schizosaccharomyces pombe; See PMID 9763455; See PMID 9852145
An08g11060	Similarity: the similarity to A. thaliana T29A15. 10 and other proteins is mainly due to the low complexity region located towards the C-terminus of the predicted protein.; Title: weak similarity to hypothetical protein T29A15.10 - Arabidopsis thaliana
An08g11070	Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; Gene-ID: suc1; Remark: a gene similar, but not identical to suc1 was patented as A. niger beta-fructofuranosidase under patentnumber WO9734004-A1.; Similarity: belongs to family 32 of glycosyl hydrolases.; See PMID 8358833
An08g11080	Remark: with the available literature information it is not possible to understand if the cloned suc1 gene is a genomic DNA or a cDNA; in the case it is a genomic DNA the data are not conflicting with the existence of the predicted ORF An08g11080; in the case the molecule is a cDNA, An08g11080 lies on the 5'UTR of suc1, therefore must be considered very questionable.; Similarity: at the DNA level, the predicted ORF mainly corresponds to a fragment of the A. niger beta-D-fructofuranosidase (suc1) gene, which is identical to ORF An08g11070.; Title: questionable ORF
An08g11090	Remark: with the available literature information it is not possible to understand if the cloned suc1 gene is a genomic DNA or a cDNA; in the case it is a genomic DNA the data are not conflicting with the existence of the predicted ORF An08g11090; in the case the molecule is a cDNA, An08g11090 lies on the 5'UTR of suc1, therefore must be considered very questionable.; Similarity: a small fragment of the predicted ORF shows local identity to a fragment of the A. niger beta-D-fructofuranosidase (suc1) gene, which perfectly corresponds to ORF An08g11070.; Title: questionable ORF
An08g11120	Title: weak similarity to protein PRO4400 from patent WO200073348-A2 - Homo sapiens
An08g11160	Similarity: the weak similarity is due only to a very short, but very well conserved stretch of amino acids.; Title: weak similarity to hypothetical CG11414 -Drosophila melanogaster
An08g11170	Similarity: the predicted ORF has a questionable structure and probably constitutes a pseudogene as,relative to Ant1 of A. niger, it contains different frameshifts and two stop codons.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8552048
An08g11180	Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster
An08g11190	Function: ankyrin is an essential link between cytoskeletal proteins and membrane bound proteins.; Similarity: strong similarity to A. niger EST SEQ ID NO:4268 of patent WO200056762-A2.; Similarity: the N-terminal part of the predicted protein shows no significant similarity.; Similarity: the similarity to various ankyrins is due to the presence of nine very well conserved ankyrin repeats in the C-terminal part of the predicted protein.; Title: similarity to ankyrin Ank1 - Mus musculus; See PMID 1386265
An08g11200	Title: similarity to hypothetical protein encoded by An03g02370 - Aspergillus niger
An08g11210	Similarity: the predicted ORF has a questionable structure and probably constitutes a pseudogene as,relative to tan1 of A. awamorii, contains different frameshifts.; Title: similarity to transposable element Tan1 -Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8625427
An08g11220	Function: mouse trophinin is a cell adhesion molecule mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces during embryo implantation and early placentation.; Similarity: the structure of the gene model is confirmed by A. niger EST SEQ ID NO:4090 of patent WO200056762-A2, which covers part of exon 2, exon 3 and part of the putative 3'UTR.; Title: weak similarity to cell adhesion protein trophinin Tro - Mus musculus; See PMID 10026108; See PMID 11089559
An08g11230	Similarity: strong similarity also to A. niger EST SEQ ID NO:4261 of patent WO200056762-A2.; Similarity: the gene model is confirmed by the two ESTs, which cover part of exon 2, the complete exon 3 and part of the putative 3'UTR.; Similarity: very weak similarity to other proteins cannot be considered functionally significant due to very different protein length.; Title: strong similarity to hypothetical protein encoded by An08g11410 - Aspergillus niger
An08g11240	Title: strong similarity to hypothetical protein encoded by An08g11430 - Aspergillus niger
An08g11250	Similarity: similarity to A. niger EST SEQ ID NO:4306 of patent WO200056762-A2.; Similarity: the weak similarity to ankyrin of D. melanogaster is due only to the presence of an ankyrin repeat.; Title: weak similarity to ankyrin - Drosophila melanogaster; See PMID 7937942
An08g11260	Similarity: the predicted ORF is very similar to the A. niger specific transposon Tncw1.; Title: strong similarity to reverse transcriptase homolog - Bombyx mori; See PMID 7623845
An08g11270	Title: questionable ORF
An08g11280	Title: questionable ORF
An08g11310	Title: weak similarity to hypothetical protein encoded by An11g07600 - Aspergillus niger
An08g11330	Similarity: local identity to A. niger EST SEQ ID NO:4145 of patent WO200056762-A2, which is completely contained within the unique exon of the predicted gene.; Title: strong similarity to hypothetical protein encoded by An14g05450 - Aspergillus niger
An08g11340	Similarity: the gene model was extracted according to the patented EST, which covers exons 2 and 3 and the putative 3'UTR.; Title: strong similarity to EST SEQ ID NO:4160 from patent WO200056762-A2 - Aspergillus niger
An08g11350	Title: weak similarity to hypothetical clone MXL8 -Arabidopsis thaliana
An08g11360	Title: weak similarity to EST an_1431 - Aspergillus niger
An08g11390	Similarity: the ORF encoded protein shows also weak similarity to the possible elongation factor 2 LM28. 365 from Leishmania major.; Title: weak similarity to hypothetical protein CAC01058.1 - Leishmania major
An08g11400	Similarity: ALK6 of Y. lipolitica is similar to cytochrome P450 family members; the similarity to the predicted protein is weak and limited to a very small part of the entire protein.; Title: weak similarity to ALK6 - Yarrowia lipolitica; See PMID 10953079
An08g11410	Similarity: the predicted ORF shows also strong similarity to EST SEQ ID NO:4261 of patent WO200056762-A2,A. niger.; Similarity: the predicted protein shows also some local weak similarity to proteins with very different size.; Similarity: the two ESTs cover the ORF completely,and part of the putative 3'UTR; the gene model was extracted based on these cDNA sequences.; Title: strong similarity to hypothetical protein encoded by An08g11230 - Aspergillus niger
An08g11420	Title: questionable ORF
An08g11430	Remark: N-terminal truncated ORF due to end of contig.; Title: strong similarity to hypothetical protein encoded by An08g11240 - Aspergillus niger [truncated ORF]
An08g11440	Remark: gankyrin expression induced in liver fibrosis accelerated the degradation of pRB during liver cirrhosis, and inactivation of p16 exon 1 by DNA hypermethylation occurred during the progression of tumor cells to poorly differentiated HCC (hepatocellular carcinoma).; Remark: similarity to rat gankyrin protein patent WO9918201-A1.; Title: similarity to gankyrin protein from patent WO9918201-A1 - Rattus norvegicus; See PMID 11301474
An08g11450	Title: weak similarity to hypothetical protein encoded by An07g06380 - Aspergillus niger
An08g11460	Title: questionable ORF
An08g11480	Title: weak similarity to AT hook-containing MAR-binding protein2 AHM2 - Triticum aestivum
An08g11510	Remark: TRAS1 contains gag- and pol-like open reading frames (ORFs) which are similar to those of non-LTR retrotransposons. Chromosomal in situ hybridization showed that TRAS1 elements are clustered at the telomeres of Bombyx chromosomes. A phylogenetic analysis using the amino acid sequence of the reverse transcriptase domain within the pol-like ORF revealed that TRAS1 falls into one lineage with R1, which is a family of non-LTR retrotransposons inserted into the same sitewithin the 28S ribosomal DNA unit in most insects.; Title: strong similarity to retrotransposable element TRAS1 - Bombyx mori; See PMID 7623845
An08g11520	Remark: Mars (methylated Ascobolus repeated sequences), fell in one family of LINE-like elements and in three families of LTR-containing retrotransposable elements. The methylation features of Mars elements were those expected if they were natural targets for the MIP (methylation induced premeiotically) previously discovered in Ascobolus.; Similarity: to RNA-directed DNA polymerases.; Title: strong similarity to LTR-containing retrotransposable elements MARS1 - Ascobolus immersus; See PMID 8811089
An08g11540	Function: interacts with dnaK,to disassemble a protein complex at the phage lambda origin of replication. Stimulates,jointly with grpE,the ATPase activity of dnaK.; Remark: similarity to E. coli OmpA-DnaJ fusion protein encoded by pUBS520-pIN-dnaJ patent EP1054063-A2.; Title: similarity to OmpA-DnaJ fusion protein encoded by pUBS520-pIN-dnaJ from patent EP1054063-A2 -Escherichia coli; See PMID 8016869
An08g11560	Title: weak similarity to hypothetical MADS box transcription factor-like protein BAB11255.1 - Arabidopsis thaliana
An08g11570	Title: weak similarity to hypothetical protein DKFZp564A022 - Homo sapiens
An08g11580	Remark: only repetitive sequences are matching.; Title: weak similarity to mucin MUC5AC - Homo sapiens; See PMID 7826332
An08g11590	Title: strong similarity to hypothetical related to spore coat protein SP96 B15I20.140 - Neurospora crassa
An08g11600	Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein 15E6. 200 from Neurospora crassa; Title: weak similarity to hypothetical protein 15E6.200 - Neurospora crassa
An08g11610	Function: kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.; Remark: the C-terminal domain shows homology to the kinesin light chain of different organisms. The N-terminal domain of the predicted ORF shows weak similarity to putative ATP /GTP-binding proteins.; Title: similarity to kinesin light chain KNLC -Loligo pealei; See PMID 8274223
An08g11620	Remark: Ant1 is related to the Tc1/mariner group of DNA transposons. Ant1 is apparently present as a single copy in strain N402 of A. niger.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8552048
An08g11630	Title: weak similarity to ubiquitin thiolesterase Yuh1 - Saccharomyces cerevisiae
An08g11650	Title: weak similarity to protein 35142 from patent EP1033405-A2 - Arabidopsis thaliana
An08g11660	Remark: a putative sequencing error results in an frameshift.; Title: similarity to kinesin light chain KLC -Plectonema boryanum [putative sequencing error]; putative sequencing error
An08g11670	Title: strong similarity to hypothetical protein encoded by An04g01250 - Aspergillus niger
An08g11680	Function: degradation of 2,5-dichloro-2,5-cyclohexadiene-1,4-diol into 2,5-dichlorohydroquinone.; Pathway: degradation of gamma-hexachlorocyclohexane.; Remark: also strong similarity to EST an_3163 Aspergillus niger.; Remark: the linC gene is essential for the assimilation of gamma-HCH in UT26.; Title: strong similarity to 2,5-dicloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linC - Pseudomonas paucimobilis
An08g11710	Title: similarity to hypothetical protein encoded by An04g07770 - Aspergillus niger
An08g11740	Remark: the ORF is N-terminally truncated due to end of contig.
An08g11770	Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: weak similarity to gluconeogenesis transcriptional regulator CAT8 - Kluyveromyces lactis; See PMID 11016849
An08g11790	Similarity: CDS is nearly identical to DNA sequence of the DNA patent database entry PATENTDNA:AAF11722.; Similarity: shares homology with a conserved domain of several protein kinases.; Similarity: the ORF encoded protein shows also strong similarity to EST SEQ ID NO:4245 of patent WO200056762-A2 from Aspergillus niger; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger
An08g11810	Title: similarity to hypothetical protein encoded by An04g07800 - Aspergillus niger
An08g11820	Similarity: contains a C2H2-type zinc-finger domain.; Title: weak similarity to Gli-Kruppel zinc-finger protein NKL isoform b - Xenopus laevis
An08g11860	Catalytic activity: cephalosporin C + H2O = deacetylcephalosporin C + acetate.; Function: cephalosporin esterase of R. toruloides is capable of interconverting a variety of cephalosporin species and the corresponding deacetylcephalosporins.; Similarity: belongs to the carboxylesterase type-B family.; Title: strong similarity to precursor of cephalosporin esterase - Rhodosporidium toruloides; See PMID 9406399
An08g11870	Title: similarity to hypothetical protein encoded by An04g07990 - Aspergillus niger
An08g11880	Title: questionable ORF
An08g11890	Similarity: contains a myb-like DNA-binding domain.; Title: similarity to hypothetical protein B24P11.50 - Neurospora crassa
An08g11910	Title: strong similarity to hypothetical protein encoded by An08g12260 - Aspergillus niger
An08g11920	Remark: the ORF encoded protein is C-terminally truncated due to the contig border.
An08g11930	Function: ankyrin participates in signal transduction and in assembly of integral membrane proteins.; Function: ankyrins are linker proteins, which connect various membrane proteins, including members of the L1 family of neural cell adhesion molecules, with the submembranous actin-spectrin skeleton.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10844021; See PMID 11018513
An08g11940	Title: strong similarity to hypothetical protein encoded by An08g12220 - Aspergillus niger
An08g11950	Function: nompC gene of D. melanogaster encodes a new ion channel that is essential for mechanosensory transduction.; Remark: the ORF encoded protein also shows similarity to other ankyrin repeat containing proteins.; Remark: the similarity of the ORF encoded protein to NOMPC is restricted to the ankyrin repeats. Unlike NOMPC,the ORF encoded Protein does not seem to be an ion channel.; Title: similarity to mechanosensory transduction channel nompC - Drosophila melanogaster; See PMID 10744543
An08g11960	Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe
An08g11990	Similarity: the similarity to the A. niger ORF An08g12030 covers only the N-terminal 30 aminoacids.; Title: weak similarity to hypothetical protein encoded by An08g12030 - Aspergillus niger
An08g12030	Similarity: the similarity to the A. niger ORF An08g11990 covers only the N-terminal 30 aminoacids.; Title: weak similarity to hypothetical protein encoded by An08g11990 - Aspergillus niger
An08g12060	Title: weak similarity to stromelysin from patent WO8707907-A - Homo sapiens
An08g12070	Remark: the similarity of the ORF encoded protein to PIM of T. parva is mainly based on repetitive amino acids.; Title: similarity to hypothetical polymorphic immunodominant molecule PIM - Theileria parva
An08g12080	Title: similarity to hypothetical protein encoded by An04g07900 - Aspergillus niger
An08g12110	Title: strong similarity to hypothetical protein EAA61328.1 - Aspergillus nidulans
An08g12120	Title: weak similarity to hypothetical mycosubtilin synthase chain mycA - Bacillus subtilis
An08g12140	Remark: the ORF encoded protein show similarity to many zinc finger transcription factors.; Title: weak similarity to finger protein Xfin -Xenopus laevis
An08g12150	Title: strong similarity to hypothetical protein encoded by An11g07550 - Aspergillus niger
An08g12160	Similarity: the ORF encoded protein shows also weak similarity to the possible elongation factor 2 LM28. 365 from Leishmania major.; Title: strong similarity to hypothetical protein encoded by An08g11390 - Aspergillus niger
An08g12170	Title: strong similarity to hypothetical protein encoded by An18g02760 - Aspergillus niger [truncated ORF]
An08g12180	Title: questionable ORF
An08g12200	Function: H. sapiens TAFII100 interacts strongly with the histone H4-related TAFII80 and the histone H3-related TAFII31, as well as a stable complex comprised of both TAFII80 and TAFII31.; Remark: distinct domains of H. sapiens TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.; Similarity: similarities are restricted to the C-terminus which contains several WD-domains presumably involved in protein-protein interactions, BlastX analysis of N-terminus showed no significant matches.; Title: similarity to transcription initiation factor TFIID 100 kD subunit TAFII-100 - Homo sapiens; nucleus; See PMID 8758937
An08g12210	Title: strong similarity to hypothetical retrotransposable element TRAS1 - Bombyx mori
An08g12220	Function: TRI7 of F. sporotrichioides is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533
An08g12230	Remark: patentmatch against protein A47074_1 Trembl.; Title: similarity to delta-latroinsectotoxin from patent GB2288807-A - Latrodectus tredecimguttatus
An08g12240	Similarity: weak similarity to SCOP domain in Cytochrome P450-NOR, nitric reductase Fusarium oxysporum.; Title: weak similarity to hypothetical protein encoded by An12g06670 - Aspergillus niger
An08g12250	Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a fatty acid anion.; Title: weak similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412
An08g12260	Title: strong similarity to hypothetical protein encoded by An08g11910 - Aspergillus niger
An18g00010	Catalytic activity: RDH of K. aerogenes catalyzes the reaction ribitol + NAD+ = D-ribulose + NADH.; Complex: RDH of K. aerogenes forms homotetramers.; Pathway: RDH of K. aerogenes is involved in the pentose interconversion pathway.; Similarity: the protein shows domain similarity to the short-chain alcohol dehydrogenases.; Similarity: the protein shows similarity to the dltE protein of B. subtilis, which belongs to the D-alanyl-lipoteichoic acid operon, but whose function is unknown.; Title: similarity to ribitol 2-dehydrogenase RDH -Klebsiella aerogenes; See PMID 1946424; See PMID 3904726; See PMID 7797557
An18g00030	Function: based on sequence similarity, Liz1 of S. pombe is thought to exhert its cell cycle control activity through cellular import of a metabolite.; Function: in S. pombe, Liz1 is required for normal cell division when ribonucleotide reductase is inhibited.; Localization: Liz1 localizes to the plasma membrane of S. pombe.; Phenotype: Inactivation of ribonucleotide reductase causes liz1(-) S. pombe cells in G2 to undergo an aberrant mitosis, resulting in chromosome missegregation and late mitotic arrest.; Remark: the substrate of Liz1 of S. pombe was not yet determined, but it was hypothesized that it could be a metabolite required for uracil biosynthesis.; Similarity: the protein shows strong similarity to a family of putative transmembrane transporters.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; plasma membrane; See PMID 9950674
An18g00040	Function: in P. stipitis, Sut1, Sut2 and Sut3 act as glucose transporters with K(m) values in the millimolar range; transport of xylose and other monosaccharides is possible, but with a considerably lower affinity.; Induction: in P. stipitis, Sut2 and Sut3 are only expressed under aerobic conditions, but independent of the carbon source.; Similarity: in P. stipitis three very similar genes called Stu1, Stu2 and Stu3 exist; Stu2 and Stu3 differ by just one amino acid.; Similarity: the gene is closely related to a number of proteins acting as sugar transporters in various fungal species; they all belong to the hexose facilitators family.; Title: strong similarity to sugar transporter Sut2 -Pichia stipitis; plasma membrane; See PMID 10048030
An18g00050	Title: strong similarity to hypothetical protein yraM - Bacillus subtilis
An18g00060	Similarity: a putative transmembrane domain shows less significant conservation.; Similarity: the N-terminus of the protein contains a putative double-stranded DNA-binding domain characteristic of the GAL4 family of zinc finger proteins.; Similarity: the protein displays similarity to the A. nidulans nirA, and to the N. crassa nit-4 proteins, both involved in the transcriptional regulation of genes involved in nitrogen utilization.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1922075
An18g00070	Function: CTP1 of S. cerevisiae is a mitochondrial citrate transport protein, member of the mitochondrial carrier family (MCF) of membrane transporters (TC 2. A. 29).; Localization: CTP1 of S. cerevisiae is located in the mitochondrial inner membrane.; Remark: in S. cerevisiae deletion of CTP1 did not lead to a phenotype, suggesting that either known alternative pathways are able to produce sufficient acetyl-CoA, or there exists a second CTP gene.; Remark: no transmembrane regions were predicted for the ORF.; Title: strong similarity to citrate transport protein Ctp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7876161; See PMID 8831672
An18g00090	Function: adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin in the synthesis of aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the protein shows strong similarity to several mammalian NAD+-dependent 15-hydroxyprostaglandin dehydrogenases.; Title: strong similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914
An18g00100	Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa
An18g00110	Title: strong similarity to hypothetical protein EAA61118.1 - Aspergillus nidulans
An18g00120	Function: in E. coli lysP is a permease that is involved in the transport across the cytoplasmic membrane of lysine.; Induction: in E. coli the activity of lysP increases with growth in acidic medium, anaerobiosis, and high concentrations of lysine.; Localization: in E. coli lysP is an integral membrane protein.; Regulation: in E. coli lysP is inhibited by the lysine analog S-(beta-aminoethyl)-L-cysteine (thiosine).; Similarity: in E. coli lysP belongs to the amino acid permease family.; Title: strong similarity to lysine-specific permease lysP - Escherichia coli; plasma membrane; See PMID 1315732; See PMID 6767681
An18g00170	Title: weak similarity to kinesin - Syncephalastrum racemosum
An18g00210	Remark: Tan1 is identical to transposon Tndm2 from Aspergillus niger.; Similarity: the Tan1 transposase is homologous to Fusarium oxysporum Fot1 and Magnaporthe grisea Pot2.; Title: similarity to transposase Tan1 - Aspergillus niger; See PMID 9003286
An18g00230	Catalytic activity: Ayr1p catalyzes the NADPH-dependent reduction of 1-acyldihydroxyacetone phosphate.; Localization: Ayr1p is localized in lipid particles and endoplasmic reticulum.; Pathway: Ayr1p catalyzes a step in the phosphatidic acid biosynthesis pathway.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610
An18g00240	Title: strong similarity to dehydrogenase LovC from patent WO200037629-A2 - Aspergillus terreus
An18g00260	Function: the avnA gene encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Phenotype: disruption of the avnA gene in the wild-type aflatoxigenic A. parasiticus strain resulted in a nonaflatoxigenic mutant which accumulated a bright yellow pigment.; Remark: at least 17 genes are involved in the aflatoxin biosynthetic pathway of Aspergillus parasiticus.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431; See PMID 10760564
An18g00280	Title: strong similarity to hypothetical protein related to host-specific AK-toxin Akt2 - Neurospora crassa
An18g00290	Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) = 3-oxoacyl- [acyl-carrier protein] + NADPH.; Pathway: fabG catalyzes a step in the fatty acid biosynthesis pathway.; Phenotype: insertional inactivation of fabG transcription blocked cell growth, thus providing indication that fabG is an essential gene.; Title: similarity to 3-ketoacyl-(acyl-carrier-protein) reductase fabG -Escherichia coli; See PMID 9642179; See PMID 7592873
An18g00300	Title: strong similarity to hypothetical protein encoded by An08g05350 - Aspergillus niger
An18g00320	Similarity: similarity corresponds to fungal Zn(2)-Cys(6) binuclear cluster domain (Pfam PF00172).; Title: weak similarity to zinc-finger protein CZF1 -Candida albicans; nucleus; See PMID 1409649
An18g00330	Remark: regulation of the actin cytoskeleton as it is exerted by P. polycephalum actin-fragmin kinase, is essential for diverse cellular processes such as cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells.; Title: similarity to actin-fragmin kinase - Physarum polycephalum; See PMID 8389700; See PMID 8896448; See PMID 10357805; See PMID 10491179
An18g00340	Similarity: weak similarity to SCOP domain d5rubb1 Ribulose 1,5-bisphosphate carboxylase-oxygenase -Rhodospirillum rubrum
An18g00370	Title: strong similarity to hypothetical transmembrane protein - Candida albicans
An18g00380	Function: The S. cerevisiae ATR1 gene product permits growth at extremely high concentrations of aminotriazole (80 mM), whereas a chromosomal deletion of ATR1 caused growth inhibition at very low concentrations (5 mM).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2123132; See PMID 3280970
An18g00400	Title: similarity to inorganic phosphate transporter PT1 - Nicotiana tabacum; plasma membrane; See PMID 11266109
An18g00410	Title: similarity to hypothetical protein T22K18.2 -Arabidopsis thaliana
An18g00420	Title: strong similarity to hypothetical neutral amino acid permease - Neurospora crassa; plasma membrane
An18g00430	Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An18g00440	Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692
An18g00460	Similarity: the encoded protein shows also similarities to E. coli tolB-like proteins.; Title: similarity to protein fragment SEQ ID NO:37063 from patent EP1033405-A2 - Arabidopsis thaliana
An18g00470	Similarity: similarity to unnamed ORF AX053132_1 Tremblnew.; Title: strong similarity to sequence 11 from patent WO0073470 - Zea mays
An18g00480	Function: efflux of the toxic drug cycloheximide by H+ antiport (TC 2. A. 1. 2. 2).; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836
An18g00490	Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. stutzeri catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Similarity: the ORF is shorter than nahG of P. stutzeri (277 compared to 437 amino acids).; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; See PMID 10433976; See PMID 10713446
An18g00500	Catalytic activity: catalyses the 14 alpha-demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8, 14,24(28)-trien-3 beta-ol as evidenced by GC-MS.; Function: CYP51s catalyses in all eukaryotes the 14alpha-demethylation of sterols.; Remark: the S. bicolor cytochrome CYP51 gene product is a P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals.; Similarity: CYP51s form the only family of P450 proteins conserved in evolution from prokaryotes to fungi,plants and mammals.; Title: strong similarity to obtusifoliol 14-alpha demethylase CYP51 - Sorghum bicolor; See PMID 9076987; See PMID 10336628
An18g00510	Catalytic activity: (D)-6-hydroxynicotine + H(2)o + o(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)o(2).; Pathway: degradation of nicotine (inducible).; Similarity: similarity to other oxygen oxidoreductases that covalently bind FAD.; Title: similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3905431
An18g00520	Function: the C. heterostrophus PKS1 gene product is a multifunctional polyketide synthase with six catalytic domains: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase, and acyl carrier protein involved in production of T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776
An18g00530	Catalytic activity: versicolorin B synthase of A. parasiticus catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of versicolorin B.; Pathway: versicolorin B synthase catalyzes an essential transformation in the aflatoxin biosynthetic pathway of A. parasiticus.; Remark: vbs of A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes; however, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: the predicted ORF shows strong similarity also to other oxidureductases of different specificity.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689; See PMID 10855719
An18g00540	Function: alpha-latrotoxin is the major component of black widow spider venom, and is particularly studied for its effects on a variety of neurosecretory cells.; Function: alpha-latrotoxin triggers a massive exocytosis in the target cells, both due to calcium influx via specifically-induced channels, and due to the binding to other calcium-independent receptors.; Similarity: the N-terminal half of the predicted ORF shows an equally good similarity to B24M22. 200 of N. crassa, an hypothetical protein related to small s protein.; Similarity: the predicted ORF contains two ankyrin repeats.; Similarity: the similarity to the alpha-latrotoxin precursor of L. tredecimguttatus involves the C-terminal half of the predicted ORF.; Title: similarity to precursor of alpha-latrotoxin -Latrodectus tredecimguttatus; extracellular/secretion proteins; See PMID 9799228; See PMID 10382267
An18g00550	Catalytic activity: S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin.; Catalytic activity: dihydromethylsterigmatocystin can also act as methyl acceptor, and the product of the reaction is dihydrosterigmatocystin.; Pathway: in A. parasiticus omtB-dmtA catalyzes a crucial step in the biosynthesis of aflatoxins.; Remark: the purification and biochemical characterization of dmtA of A. parasiticus are described in a journal article not indexed by PubMed: Appl Environ Microbiol, January 1998, p. 166-171, Vol. 64, No. 1.; Similarity: omtB of A. parasiticus is almost identical to dmtA (also known as MT-I) of the same organism.; Similarity: the predicted ORF shows strong similarity also to several methyltransferases with different specificities.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; cytoplasm; See PMID 10543813; See PMID 10806361
An18g00560	Similarity: the similarity to fixR homolog of A. tumefaciens involves only the N-terminal half of the predicted ORF.; Title: weak similarity to hypothetical fixR homolog - Agrobacterium tumefaciens
An18g00570	Title: similarity to hypothetical protein CAD36967.1 - Neurospora crassa
An18g00590	Remark: C-terminally truncated ORF due to contig border.
An18g00600	Localization: the association of hsp30 of N. crassa with mitochondria is reversible and hsp30 dissociates after cells are returned to normal temperature.; Phenotype: disruption of hsp30 in N. crassa causes extreme sensitivity to the combination of temperature stress and carbohydrate limitation, suggesting that hsp30 may be important for efficient carbohydrate utilization during high temperature stress.; Remark: N-terminally truncated ORF due to contig border.; Similarity: hsp30 of N. crassa is related to the alpha-crystallin/Hsp20 family; Similarity: the predicted ORF shows stronger similarity to HSP30 of A. nidulans, which was not functionally characterized.; Title: strong similarity to heat shock protein hsp30 - Neurospora crassa [truncated ORF]; localisation:mitochondrion; See PMID 2144284; See PMID 7761443
An18g00620	Function: gamma-TIP of A. thaliana is a water-specific channel of the vacuolar membrane; it may play a role in the control of cell turgor and cell expansion.; Induction: gamma-TIP of A. thaliana is induced by gibberellins.; Similarity: gamma-TIP of A. thaliana belongs to the transmembrane channel major intrinsic protein (MIP) family,comprising water and small neutral solutes (e. g. glycerol) transporters.; Title: similarity to tonoplast intrinsic protein TIP-gamma - Arabidopsis thaliana; vacuole; See PMID 8155880; See PMID 8508761
An18g00650	Remark: the structure of the gene is questionable.; Title: weak similarity to hypothetical protein AAA73346.1 - Mycobacterium tuberculosis
An18g00660	Catalytic activity: S-Adenosyl-L-methionine is used as the methyl-group donor.; Function: CCoAOMT of N. tabacum is involved in the biosynthesis of lignin.; Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE758937.; Similarity: the predicted ORF shows strong similarity or similarity to a huge number of putative or characterized O-methyltransferases of bacterial, fungal or plant origin, with different specificities and functions.; Title: similarity to caffeoyl-CoA O-methyltransferase CCoAOMT-1 - Nicotiana tabacum; See PMID 9484483
An18g00670	Title: weak similarity to p45 NF-E2 related factor 2 NRF2 - Mus musculus; See PMID 8943040
An18g00690	Title: similarity to hypothetical esterase SCD10.24 - Streptomyces coelicolor
An18g00700	Function: in S. cerevisiae FLR1 confers resistance to cerulenin, benomyl, methotrexate and diazaborine.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Induction: FLR1 of S. cerevisiae is dramatically induced by AP-1 and PDR3, two transcription factors known to mediate cellular resistance to toxicants.; Remark: FLR1 of S. cerevisiae is also known as YBR008C.; Similarity: the predicted ORF and FLR1 of S. cerevisiae show strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926; See PMID 10102370; See PMID 10572257; See PMID 10903515
An18g00710	Title: strong similarity to hypothetical protein CGA009 - Rhodopseudomonas palustris
An18g00720	Title: questionable ORF
An18g00730	Function: CAP59, as well as the other two capsule-associated proteins CAP60 and CAP64, are essential for the formation or the stabilization of the capsule in C. neoformans.; Function: the polysaccharide capsule is one of the most important virulence factors for the pathogenic fungus C. neoformans.; Similarity: the similarity to CAP59 of C. neoformans does not involve the N-terminal region of the two proteins.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; cell wall; See PMID 8007987; See PMID 9573112
An18g00750	Title: similarity to diagnostic protein #11744 from patent WO200175067-A2 - Homo sapiens
An18g00760	Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: human tankyrases have been patented by various companies: see patents WO104326, WO100849,WO9964606.; Similarity: ankyrin repeats (ANK) are tandemly repeated modules of about 33 amino acids, that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF shows similarity also to the ZU5 domain present in ZO-1 and Unc5-like netrin receptors, which function remains unknown.; Similarity: the similarity to tankyrase of H. sapiens and other proteins is mainly due to the presence of an ankyrin repeat.; Title: weak similarity to TRF1-interacting ankyrin-related ADP-ribose polymerase tankyrase - Homo sapiens; See PMID 9822378
An18g00790	Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443
An18g00810	Function: the function of frnE of Streptomyces is unknown.; Localization: frnE of Streptomyces is not membrane-bound.; Remark: frenolicin B is an antibiotic used as an anticoccidial agent.; Remark: frnE of Streptomyces belongs to the frenolicin gene cluster.; Title: similarity to frenolicin gene E product frnE from patent EP806480-A2 - Streptomyces sp.
An18g00820	Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE759903.; Similarity: the predicted ORF shows similarity or weak similarity to some putative O-methyltransferases, and contains some structural features common to such class of enzymes.; Title: strong similarity to hypothetical mll5689 -Mesorhizobium loti
An18g00830	Title: weak similarity to EST an_2841 - Aspergillus niger
An18g00840	Remark: TrpG of patent WO9806734-A1 is identical to trpG protein of Corynebacterium glutamicum, a putative protein predicted to have glutamine amidotransferase activity.; Similarity: the predicted ORF shows much stronger similarities to B. carinata, S. pombe, and A. thaliana hypothetical proteins.; Title: similarity to protein CJAS1 from patent WO200263018-A2 - Brassica napus
An18g00850	Phenotype: null mutation of paiB in B. subtilis is lethal.; Remark: in B. subtilis paiB is the second ORF of the pai operon, involved in negative control of sporulation and degradative-enzyme production.; Title: similarity to transcription regulator paiB -Bacillus subtilis; See PMID 2108124
An18g00860	Function: pro1 is essential in S. macrospora for the formation of multicellular fruiting bodies called perithecia.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the similarity to pro1 of S. macrospora is only due to the conserved fungal zinc-finger motiv.; Title: similarity to zinc-finger transcription factor pro1 - Sordaria macrospora; See PMID 10224253
An18g00870	Catalytic activity: 2,3-dihydroxybenzoate = catechol + co(2).; Complex: O-pyrocatechuate decarboxylase of A. niger is a homotetramer.; Pathway: last step in the metabolism of indole to catechol.; Remark: the catalytic active site of O-pyrocatechuate decarboxylase of A. niger was characterized and it is not conserved in the predicted ORF.; Remark: the gene for O-pyrocatechuate decarboxylase of A. niger was not yet cloned; the database entries are derived from peptide mapping experiments.; Title: similarity to O-pyrocatechuate decarboxylase - Aspergillus niger; See PMID 7601088
An18g00880	Catalytic activity: dihydrofolate reductase catalyzes the reaction: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.; Pathway: dihydrofolate reductase catalyzes essential steps for de novo glycine and purine synthesis and for the conversion of dUMP to dTMP.; Similarity: the similarity to dfr1 of S. pombe involves the C-terminal part of the predicted ORF and the N-terminal part of the dihydrofolate reductase enzyme.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538
An18g00900	Catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: peptidyl-prolyl cis-trans isomerases (PPIases) accelerate the folding of proteins.; Remark: FPR1 of S. cerevisiae is also called FKB1,RBP1 or YNL135C.; Remark: FPR1 of S. cerevisiae is the molecular target of the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin.; Similarity: FPR1 belongs to the FKBP-type PPIase family; these proteins share common structural and functional features with the cyclophilins, but these last are responsive to heat shock.; Title: strong similarity to peptidyl-prolyl isomerase Fpr1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1701173; See PMID 1704127; See PMID 7685914
An18g00910	Catalytic activity: salE of Acinetobacter have esterase activity against short-chain alkyl esters of 4-nitrophenol but is also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Phenotype: salE mutants of Acinetobacter lose the ability to utilize only ethyl and methyl salicylates of the esters tested as sole carbon sources.; Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE759031.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An18g00940	Catalytic activity: L-sorbose + acceptor <=> 5-dehydro-D-fructose + reduced acceptor.; Cofactor: FAD.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans; See PMID 9023923
An18g00950	Title: weak similarity to hypothetical acetyltransferase MK0549 - Methanopyrus kandle
An18g00960	Function: Hnm1 of S. cerevisiae is the unique coline permease in yeast (Km of 0. 5 micromolar).; Regulation: in S. cerevisiae, expression of HNM1 gene is regulated by the phospholipid precursors inositol and choline and this regulation involves the trans-acting factors Ino2p, Ino4p and Opi1p.; Remark: alternate name for S. cerevisiae Hnm1 is YGL077c.; Similarity: Hnm1 of S. cerevisiae belongs to the APC family, which encompasses amino acid permeases more related to the mammalian cationic amino-acid transporter family (Tea/ecoR).; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 7520996; See PMID 8264542; See PMID 2203793
An18g00970	Title: weak similarity to hypothetical protein BAA96207.1 - Oryza sativa
An18g00980	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p is likely to be involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An18g00990	Title: strong similarity to EST an_1359 -Aspergillus niger
An18g01000	Similarity: the nucleotide sequence of the ORF shows strong similarity to the ESTs an_2192 and an_2204 of A. niger.; Title: strong similarity to EST an_2192 -Aspergillus niger
An18g01010	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An18g01020	Complex: the estimated molecular mass of the purified gentisate 1, 2-dioxygenase of P. alcaligenes was 154 kDa, with a subunit mass of 39 kDa. its structure is deduced to be a tetramer.; Remark: gentisate 1,2-dioxygenase of P. alcaligenes exhibits typical saturation kinetics and has an apparent Km of 92 microM for gentisate. this enzyme has broad substrate specificities towards alkyl and halogenated gentisate analogs.; Similarity: the predicted A. niger protein shows strong similarity to gentisate 1,2-dioxygenase of P. alcaligenes and conserved hypothetical proteins from other procaryotic species.; Title: strong similarity to gentisate 1,2-dioxygenases xlnE - Pseudomonas alcaligenes; See PMID 10049846
An18g01030	Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases. best matches are with putative salicylate hydroxylases of several procaryotic species.; Title: strong similarity to maackiain detoxification protein 1 MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199
An18g01040	Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Similarity: the predicted A. niger protein shows similarity to acetate regulatory DNA binding protein FacB (facB) from A. nidulans, which belongs to the GAL4-type zinc cluster transcriptional activators.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408
An18g01050	Catalytic activity: lignostilbene-alpha,beta-dioxygenase isozymes (LSD-I, II, and III) of P. paucimobilis catalyse the reaction 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin; Cofactor: lignostilbene-alpha,beta-dioxygenase isozymes (LSD-I, II, and III) of P. paucimobilis require iron as a cofactor.; Complex: LSD-I, II, and III consist of alpha alpha,alpha beta, and beta beta subunits, respectively. they show different specificities for several substrates that are stilbene and styrene derivatives.; Function: LSD of P. paucimobilis catalyses the oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. it is responsible for the degradation of a diarylpropane-type structure in lignin.; Similarity: the predicted A. niger protein shows strong similarity to subunit lsdB of lignostilbene-alpha,beta-dioxygenase isozyme LSD-III of P. paucimobilis and related dioxygenases from several plant species.; Title: strong similarity to subunit lsdB of lignostilbene-alpha,beta-dioxygenase isozyme LSD-III -Pseudomonas paucimobilis; See PMID 7763880; See PMID 8534977
An18g01060	Catalytic activity: 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli catalyses the reaction 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.; Pathway: 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli is involved in tyrosine and phenylalanine metabolism.; Similarity: the predicted A. niger protein shows strong similarity to 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli and many putative 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerases from several procaryotic and eucaryotic organisms.; Title: strong similarity to 5-carboxymethyl-2-hydroxymuconate delta-isomerase -Escherichia coli; cytoplasm; See PMID 8223600
An18g01070	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An18g01090	Catalytic activity: lysophospholipase catalyses the reaction 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a fatty acid anion.; Pathway: lysophospholipase is involved in phospholipid degradation.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequences lysophospholipase (sequence 5 and sequence 7) of patents WO0127251-A/5 and WO0127251-A/7 from A. oryzae (AC# AX112082 and AC# AX112084) and to other fungal lysophospholipases.; Title: strong similarity to lysophospholipase from patent WO0127251-A - Aspergillus oryzae; extracellular/secretion proteins; See PMID 1722456
An18g01100	Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence alcohol dehydrogenase (sequence 19) of patent EP0845532-A/19 from an unclassified organism (AC# A92108) and to other zinc-containing dehydrogenases.; Title: strong similarity to alcohol dehydrogenase from patent EP0845532-A - Unclassified organism; cytoplasm
An18g01120	Catalytic activity: versicolorin B synthase from A. parasiticus catalyses the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Pathway: versicolorin B synthase from A. parasiticus is involved in the aflatoxin biosynthetic pathway.; Remark: a splice site was detected upstream of the START codon.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: the genes encoding the aflatoxin biosynthetic enzymes in A. parasiticus are clustered.; Remark: versicolorin B synthase from A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes, but does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: the predicted A. niger protein shows strong similarity to versicolorin B synthase from A. parasiticus and other oxidoreductases.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689
An18g01130	Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to the protein fragment (SEQ ID NO: 51484) of patent EP1033405-A2 from A. thaliana (AC# AAG41385) and to putative sterol desaturase family proteins.; Title: similarity to protein fragment SEQ ID NO:51484 from patent EP1033405-A2 - Arabidopsis thaliana
An18g01140	Title: similarity to ketopantoate reductase -Salmonella typhimurium; cytoplasm; See PMID 7519593; See PMID 9488683
An18g01150	Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353
An18g01170	Catalytic activity: the NAP protein of Z. mays catalyses the reaction NAD(+) + {ADP-D-ribosyl}(N)-acceptor <=> nicotinamide + {ADP-D-ribosyl}(N+1)-acceptor.; Function: the NAP protein of Z. mays is involved in programmed cell death or apoptosis.; Localization: the NAP protein of Z. mays is a nuclear enzyme.; Remark: the ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.; Remark: the NAP polynucleotide sequences can be used for modulation of programmed cell death in eukaryotic cells. the method is used, specifically in plants, to induce, or protect against, programmed cell death,depending on the extent to which PARP activity is reduced. reducing expression of endogenous NAP class PARP only is also used to modulate programmed cell death, to increase growth rate and to produce plant cells that are more tolerant of stress (cold, chemical treatments, pathogens,pests, drought, heat, etc., or during transformation). particular applications are generation of plants that are resistant to fungi or nematodes; are male or female sterile; or have better seed-shatter properties. the methods are also used to improve growth of transformed plant cells (and derived calli or complete plants).; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence poly(ADP-ribose) polymerase NAP protein of patent WO200004173-A1 from Z. mays (AC# AAY68834) and from many other eucaryotic organisms.; Title: strong similarity to poly(ADP-ribose) polymerase NAP protein from patent WO200004173-A1 - Zea mays; nucleus; See PMID 11246023; See PMID 11376691; See PMID 11385634
An18g01180	Function: penicillin V amidohydrolase (PVA) from F. oxysporum is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence penicillin V amidohydrolase (PVA) of patent US5516679-A from F. oxysporum (AC# AAW00291).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; extracellular/secretion proteins
An18g01200	Function: ord1 of A. flavus converts O-methylsterigmatocystin to aflatoxin B1.; Pathway: ord1 of A. flavus catalyzes the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the predicted A. niger protein shows strong similarity to O-methylsterigmatocystin (OMST)-oxidoreductase (ord1) from A. flavus, which belongs to the CYP64 family of cytochrome P450-type monooxygenases.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099
An18g01210	Function: SRPK2 from M. musculus phosphorylates SF2/ASF, a member of SR splicing factors.; Remark: overexpression of murine SRPK2 causes disassembly of cotransfected SF2/ASF and endogenous SC35. SRPK family members may regulate the disassembly of the SR proteins in a tissue-specific manner.; Similarity: the predicted A. niger protein shows similarity to SRPK2 from M. musculus and strong similarity to putative serine/threonine protein kinases from several eucaryotic organisms.; Title: similarity to SR-protein-specific kinase SRPK2 - Mus musculus; nucleus; See PMID 9446799
An18g01220	Function: in S. cerevisiae, mutants (dal5) that lack allantoate transport have been isolated. these strains also exhibit a 60% loss of allantoin transport capability.; Regulation: in S. cerevisiae Dal5 appears to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition.; Regulation: in S. cerevisiae allantoate uptake is constitutive.; Similarity: the predicted A. niger protein shows strong similarity to allantoate permease gene (DAL5) from S. cerevisiae, which belongs to the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3549700
An18g01230	Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529
An18g01240	Catalytic activity: NahW of P. stutzeri catalyzes the conversion salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Similarity: the predicted A. niger protein shows similarity to salicylate hydroxylase (nahW) of P. stutzeri,which belongs to the NADH-dependent monooxygenase superfamily.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990
An18g01250	Title: similarity to hypothetical protein encoded by An16g00840 - Aspergillus niger
An18g01290	Title: strong similarity to hypothetical protein encoded by An13g01340 - Aspergillus niger
An18g01300	Remark: paiB from B. subtilis seems to be essential.; Similarity: the predicted A. niger protein shows weak similarity to transcription regulator 2 of the pai operon of B. subtilis and conserved hypothetical proteins from several procaryotic organisms.; Title: similarity to transcription regulator paiB -Bacillus subtilis; See PMID 2108124
An18g01320	Function: BAR1 of S. cerevisiae selectively cleaves the 6-Leu-|-Lys-7 bond in the pheromone alpha-mating factor. BAR1 activity is abolished by in vitro mutation of an aspartic acid predicted to be in the active site.; Induction: secretion of BAR1 of S. cerevisiae is stimulated to as much as five times the basal level by exposure of cells to alpha-factor.; Localization: BAR1 of S. cerevisiae is secreted into the periplasmic space of MATa cells.; Remark: BAR1 of S. cerevisiae is already active in early compartments of the secretory pathway. Bar1 protease tolerates large N-terminal extensions of its substrate and does not require Golgi-specific modifications such as outer-chain glycosylation for activity.; Remark: the protein sequence of barrier protease BAR1 of S. cerevisiae is covered by patent WO9118988-A (AC# AAR20109). the patented barrier protease is useful in industrial processes where leucine-lysine or leucine-arginine cleavage is required at low pH or high temperature. barrier protease may also be used in the production and isolation of proteins made by genetic engineering methods, e. g. to cleave fusion proteins at Leu-Arg bonds.; Similarity: the predicted A. niger protein shows strong similarity to extracellular protease precursor BAR1 of S. cerevisiae which belongs to the subfamily A1 of aspartic-type peptidases.; Title: strong similarity to extracellular protease precursor Bar1 - Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 3124102; See PMID 6345506; See PMID 6397123; See PMID 9249020
An18g01340	Remark: the patent does not provide further information about the function of the protein, except for a claim of phytase activity.; Similarity: the predicted A. niger protein shows strong similarity to protein sequence 11 from patent EP0684313-A/11 and several putative phytases.; Title: strong similarity to sequence 11 from patent EP0684313-A - Unclassified organism
An18g01350	Remark: HA protein regulates homeostasis and adaptation. the C. glutamicum HA genes (I) can be used in vectors for expression in host cells and production of fine chemicals, such as, an organic acid, proteinogenic or nonproteinogenic amino acid (preferred), purine or pyrimidine base, nucleoside, nucleotide, lipid, saturated or unsaturated fatty acid, diol, carbohydrate, aromatic compound, vitamin, cofactor, polyketide or enzyme. the amino acids produced can be lysine, glutamine, glutamate,alanine, aspartate, glycine, serine, threonine, methionine,cysteine, valine, leucine, isoleucine, arginine, proline,histidine, tyrosine, phenylalanine, or tryptophan. the fine chemical production can be modulated. the presence of (I) or HA proteins encoded by then are used for diagnosing the presence or activity of Corynebacterium diphtheriae. (I) can be used to map the C. glutamicum genome or can be used as markers for genetically engineered Corynebacterium or Brevibacterium. the HA proteins encoded by the (I) are used to maintain homeostasis in C. glutamicum or help the microorganism to adapt to different environmental conditions.; Similarity: the predicted A. niger protein shows strong similarity to HA protein sequence SEQ ID NO:420 from patent WO200100842-A2 (AC# AAB79232), which is a monooxygenase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:420 from patent WO200100842-A2 - Corynebacterium glutamicum
An18g01360	Function: S. cerevisiae DUR3 is a urea symporter mediating urea import.; Induction: high-level expression of S. cerevisiae DUR3 is inducer dependent, requiring functional DAL81 and DAL82 genes.; Regulation: expression of S. cerevisiae DUR3 is regulated in a manner similar to that of other genes in the allantoin pathway.; Repression: DUR3 expression is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Repression: maintenance of S. cerevisiae DUR3 mRNA at uninduced, nonrepressed basal levels requires the negatively acting DAL80 gene product.; Similarity: S. cerevisiae DUR3 belongs to the major facilitator family.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8335627
An18g01380	Function: YCF1 from S. cerevisiae is required for cadmium resistance. S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Remark: mutagenesis experiments demonstrate that conserved amino acid residues, functionally critical in the human cystic fibrosis transmembrane conductance regulator (hCFTR), play a vital role in YCF1-mediated cadmium resistance.; Remark: substitution of a serine to alanine residue in a potential protein kinase A phosphorylation site in a central region of YCF1, which displays sequence similarity to the central regulatory domain of hCFTR, also rendered YCF1 nonfunctional.; Remark: the YCF1 gene of S. cerevisiae is an MgATP-energized, uncoupler-insensitive vacuolar membrane glutathione S-conjugate transporter.; Similarity: the predicted A. niger protein shows strong similarity to cadmium factor (YCF1) from S. cerevisiae, which belongs to the ATP binding cassette (ABC) protein superfamily of membrane transporters.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 7521334; See PMID 7798263; See PMID 8626454; See PMID 8990158
An18g01390	Function: the CUP1 gene, and its copper-dependent transcriptional activator ACE1 play a key role in mediating copper resistance in S. cerevisiae.; Similarity: the predicted A. niger protein shows similarity to the copper homeostasis protein CUP9 from S. cerevisiae. the predicted A. niger protein shows strong similarity to the homeobox domain of many homeotic proteins.; Title: similarity to copper homeostasis protein Cup9 - Saccharomyces cerevisiae; nucleus; See PMID 7969120
An18g01400	Function: the MCT3 transporter from Rattus norvegicus is a proton-linked monocarboxylate transporter. it catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate,branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,beta-hydroxybutyrate and acetate.; Similarity: the predicted A. niger protein shows strong similarity to the monocarboxylate transporter 3 (MCT3) of R. norvegicus, which belongs to the major facilitator superfamily.; Title: strong similarity to monocarboxylate transporter 3 MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555
An18g01410	Title: strong similarity to hypothetical protein B2J23.120 - Neurospora crassa
An18g01430	Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: alcohol dehydrogenase ADH-T from B. stearothermophilus is involved in glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: the protein sequence of alcohol dehydrogenase ADH-T from B. stearothermophilus NCA1503 is covered by patent JP04218378-A (AC# AAR26874).; Similarity: the predicted A. niger protein shows strong similarity to thermostable alcohol dehydrogenase ADH-T from B. stearothermophilus NCA1503, which belongs to the zinc alcohol dehydrogenase (ADH) family.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 1735726; See PMID 10971204
An18g01440	Similarity: the predicted A. niger protein shows local similarity to the hypothetical protein mll8086 from M. loti.; Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa
An18g01450	Function: ordA of A. parasiticus is involved in the aflatoxin biosynthesis and converts O-methylsterigmatocystin (OMST) to aflatoxins B1 or G1 and converts dihydro-O-methylsterigmatocystin (DHOMST) to aflatoxins B2 or G2.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: it is assumed that the ORF is N-terminally shorter and has another start codon 5' to the predicted one; the ORF is around 400 amino acids shorter than most of the homologues cytochrome p450 proteins.; Remark: ordA of A. parasiticus is also called cytochrome p450 64, cyp64 or omst oxidoreductase.; Similarity: the ORF shows similarity to several cytochrome P450 related proteins from different species.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus; See PMID 9532734
An18g01460	Catalytic activity: cyclohexanol dehydrogenases convert cyclohexanol + NAD(+) <=> cyclohexanone + NADH.; Function: chnA of A. sp. is an alcohol dehydrogenases proposed to catalyze the conversion of cyclohexanol to cyclohexanone (EC 1. 1. 1. 245).; Phenotype: cyclohexanol was detected as the major intermediate accumulated in the chnA mutant of A. sp.; Remark: chnA of A. sp. is encoded in the gene cluster for cyclohexanol oxidation.; Similarity: the ORF shows similarity to several dehydrogenases from different species and with various specificities.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013
An18g01470	Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Similarity: the ORF shows similarity to monooxigenases from several species and with different functions.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719
An18g01480	Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, with is involved in mushroom morphogenesis.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome p450 related protein eln2 - Coprinus cinereus; See PMID 10779399
An18g01490	Function: alr2 of S. cerevisiae is an uptake transporter for inorganic cations, e. g. magnesium, which presence seems to be important for resistance to the toxic effect of aluminum.; Remark: alr2 of S. cerevisiae is also called YFL050C.; Similarity: the predicted ORF is 395 amino acids shorter at the N-terminus and 57 amino acids shorter at its C-terminal end than alr2 of S. cerevisiae (nearly the same is true for alr1 of S. cerevisiae).; Title: strong similarity to ion transporter Alr2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9430719
An18g01500	Title: strong similarity to hypothetical protein encoded by An15g02540 - Aspergillus niger
An18g01510	Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF
An18g01520	Function: due to the presence of a putative 'zinc cluster' motif and its low (16%) but significant similarity with the DNA-directed DNA polymerase of hepatitis B virus,it was assumed that qutH of A. nidulans is a DNA-binding protein, which is possibly involved in the regulation of genes essential for the utilisation of protocatechuic acid.; Function: due to the similarity of the ORF to oxidoreductases, it is here assumed that the ORF is encoding a protein with oxidoreductase activity.; Similarity: the ORF shows similarity to several oxidoreductases from different species.; Title: strong similarity to quinic-acid utilisation gene qutH - Aspergillus nidulans; See PMID 2976880
An18g01530	Function: pth11 of M. grisea is involved in host surface recognition for the initiation of appressorium formation, which is important in plant infection.; Phenotype: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Remark: on the same contig another ORF shows similarity to pth11 of M. grisea, see 130cg.; Similarity: the ORF is 85 amino acids shorter at its N-terminus and 155 amino acids shorter at the C-terminal end than pth11 of M. grisea.; Title: strong similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; See PMID 11113382
An18g01540	Function: TRI101 of F. sporotrichioides conferred significant increased tolerance to the mycotoxin DAS (trichothecene 4,15-diacetoxyscirpenol), which is harmful for vertebrates.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the modification of T-2 toxin, which inhibits protein synthesis in eukaryotes.; Phenotype: TRI101 mutants of F. sporotrichioides were altered in their abilities to synthesize T-2 toxin and accumulated isotrichodermol and small amounts of 3,15-didecalonectrin and 3-decalonectrin, trichothecenes.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 9762900; See PMID 10583973; See PMID 10960733
An18g01550	Title: similarity to hypothetical protein AAM43672.1 - Dictyostelium discoideum
An18g01560	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF
An18g01570	Function: pth11 of M. grisea pth11 is involved in host surface recognition for the initiation of appressorium formation, which is important in plant infection.; Phenotype: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Remark: on the same contig another ORF shows strong similarity to pth11 of M. grisea, see 160wg.; Similarity: the ORF is 92 amino acids shorter at the N-terminal end and 165 amino acid its C-terminus than pth11 of M. grisea.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; See PMID 11113382
An18g01580	Catalytic activity: pca1 of P. purpureum converts H(2)CO(3) <=> CO(2) + H(2)O with the usage of zinc as cofactor.; Function: carbonic anhydrases catalyze the reversible hydration of carbon dioxide.; Remark: an alternate name for pca1 of P. purpureum is gtpca1.; Similarity: the ORF shows similarity to several carbonic anhydrases from different species and with various cellular functions.; Title: strong similarity to carbonic anhydrase pca1 - Porphyridium purpureum; See PMID 8910506; See PMID 11316870
An18g01590	Catalytic activity: cat2 of C. tropicalis catalyses acetyl-CoA + carnitine <=> CoA + O-acetylcarnitine.; Function: cat2 of C. tropicalis is specific for the acetylation of short chain fatty acids and may also be involved in the transport of acety-CoA into mitochondria.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760390.; Title: strong similarity to carnitine O-acetyltransferase cat2 - Candida tropicalis; inner membrane
An18g01600	Function: srpk2 was first found to mediate the interaction and localization of pre-mRNA splicing factors by phosphorylating the SR (serine/arginine-rich) family of splicing factors and therefore probably controls the activity of splicing.; Phenotype: overexpression of srpk2 in M. musculus causes disassembly of cotransfected SF2/ASF and endogenous SC35.; Similarity: the ORF shows similarity to several protein kinases from different species and with various specificity.; Title: strong similarity to serine/arginine-rich protein-specific kinase srpk2 - Mus musculus; deleted EC_number 2.7.1.37; See PMID 9472028
An18g01610	Function: srb4 of S. cerevisiae is a component of the multi subunitcomplex, which binds to RNA polymerase II and is essential for efficient establishment of the transcription initiation apparatus.; Phenotype: the S. cerevisiae srb4 the null mutant is inviable and srb4 mutants display global defects in mRNA synthesis.; Remark: an alternate name for srb4 of S. cerevisiae is YER022w.; Title: strong similarity to RNA polymerase II suppressor protein Srb4 - Saccharomyces cerevisiae; nucleus; See PMID 8187178
An18g01620	Catalytic activity: linoleate isomerases catalyse the isomerisation of 9-cis,12-cis-octadecadienoate <=> 9-cis,11-trans-octadecadienoate.; Function: linoleate isomerase of patent WO9932604-A1 is used to produce conjugated linoleic/linolenic acid (CLA) from oils such as sunflower oil, safflower oil, corn oil, linseed oil, etc.; Similarity: the ORF shows strong similarity to myosin-crossreactive antigen, which could induce autoimmune reactions in vertebrates.; Title: strong similarity to linoleate isomerase from patent WO9932604-A1 - Lactobacillus reuteri
An18g01630	Catalytic activity: HDNO of A. oxidans catalyses (D)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Induction: HDNO of A. oxidans requires FAD in the enzymatic assay for maximal enzyme activity.; Similarity: the ORF shows similarity to several FAD-dependent oxygenases from different species and with various specificity.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3905431
An18g01640	Function: TSase of G. frondosa catalyzes the trehalose synthesis from alpha-D-glucose 1-phosphate and D-glucose.; Similarity: the ORF shows similarity to a clock-controlled gene (ccgs) of N. crassa with unknown function.; Title: strong similarity to trehalose synthase TSase - Grifola frondosa; See PMID 9763690; See PMID 9797287
An18g01660	Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Similarity: the ORF overlaps with the 5' region of the A. niger pfkA gene.; Title: questionable ORF
An18g01670	Catalytic activity: pfkA of A. niger is catalysing ATP + D-fructose 6-phosphate <=> ADP + D-fructose 1,6-bisphosphate.; Function: pfkA of A. niger is active in a key control step of glycolysis.; Gene-ID: pfkA; Similarity: the ORF overlaps with the sequence of entry EMBL:ANPFKA (A. niger pfkA gene); cytoplasm; See PMID 6223622; See PMID 8020755; See PMID 9101728; See PMID 2936730
An18g01680	Catalytic activity: NADH dehydrogenases catalyse NADH + acceptor <=> NAD(+) + reduced acceptor.; Function: ndh of P. fluorescens is involved in colonization of this bacterium.; Phenotype: in an oxygen-poor medium mutant PCL1201 of P. fluorescens, which carries a mutation in the ndh gene showed a decreased growth rate.; Remark: the sequence of the database entry EMBL:ANPFKA (A. niger pfkA gene) overlaps with the ORF due a probably wrong nummer of 4658 bp for the coding sequence of the A. niger protein, which is encoded 3'.; Similarity: the ORF is 112 amino acids shorter at its C-terminal end than ndh of P. fluorescens.; Title: similarity to NADH dehydrogenase II ndh -Pseudomonas fluorescens; localisation:mitochondrion; See PMID 9675892
An18g01690	Title: strong similarity to hypothetical protein YOR155c - Saccharomyces cerevisiae
An18g01700	Function: qutD of E. nidulans is involved in quinic acid transport with similarity to the maltose transport protein MAL61.; Phenotype: mutations in the qutD gene of A. nidulans cause the loss of ability to grow upon quinic acid as sole carbon source in media at normal pH 6. 5 and failure to induce three enzyme activities specifically required for metabolism to protochatechuic acid.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759752.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2976880; See PMID 2835177
An18g01720	Function: CaMDR1 of C. albicans the confers insensitivity to the anti-mitotic drug, benomyl, and to the dihydrofolate reductase inhibitor, methotrexate.; Remark: seven different mutant alleles of CaMDR1 from C. albicans showed distinct drug resistance profiles.; Similarity: the ORF shows similarity to several major facilitator proteins from different species.; Title: strong similarity to benomyl/methotrexate resistance protein MDR1 - Candida albicans; plasma membrane; See PMID 8031026; See PMID 2062311
An18g01730	Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein encoded by An12g00980 - Aspergillus niger [truncated ORF]
An18g01740	Catalytic activity: nitrilases convert a nitrile + H(2)O <=> a carboxylate + NH(3).; Function: nitrile-hydrating enzymes produced by bacteria and fungi catalyse the conversion of a large number of chemically diverse nitriles, including many economically important compounds used industrially for chemical synthesis of amides and acids.; Similarity: the ORF shows similarity to several nitrilases from different species.; Title: strong similarity to aliphatic nitrilase -Rhodococcus rhodochrous; See PMID 3073055
An18g01750	Similarity: the ORF shows similarity to several short-chain dehydrogenases from different species, it is therefore not possible to predict its specific function.; Title: similarity to 3-dehydroecdysone 3alpha-reductase - Spodoptera littoralis; See PMID 10861234
An18g01760	Function: mst1 of A. muscaria is a H(+)/monosaccharide cotransporter necessary for the supply of plant-derived carbohydrates to the fungus.; Induction: in mycorrhizas as well as in hyphae grown at monosaccharide concentrations above 5 mM, the amount of mst1 transcript in A. muscaria increased fourfold.; Similarity: the ORF shows similarity to several hexose transport proteins from different species.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane
An18g01770	Similarity: the ORF contains a zinc-finger domain,which shows similarity to other zinc-finger domains from various proteins.; Title: similarity to hypothetical zinc-finger protein SPBC15D4.02 - Schizosaccharomyces pombe
An18g01780	Catalytic activity: the dihydropteridine reductase activity of hmp from E. coli converts NAD(P)H + 6,7-dihydroteridine = NAD(P)(+) + 5,6,7,8-tetrahydropteridine.; Function: hmp of E. coli possesses dihydropteridine reductase activity and has nitric oxide dioxygenase activity.; Function: hmp of E. coli seems to reduce the complexed Fe3+ iron of siderophores to Fe2+, thus releasing it from the chelator.; Induction: hmp of E. coli needs FAD and protoheme IX as cofactors.; Remark: a putative frameshift due to a possible sequencing error was corrected at position 53851 of the DNA sequence (1 bp to much).; Remark: hmp of E. coli is also called HMPA, FSRB or B2552.; Remark: the combination of FNR-like and haemoglobin-like regions in HMP represents a novel pairing of functionally and structurally distinct domains.; Title: strong similarity to flavohemoglobin hmp -Escherichia coli [putative frameshift]; cytoplasm; putative frameshift; See PMID 1601132
An18g01790	Remark: the ORF is questionable due to its short lenght of only 91 amino acids.; Title: questionable ORF
An18g01800	Function: c-tak1 (for Cdc twenty-five C associated protein kinase) phosphorylates Cdc25C in vitro and by this regulates the activity of the dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2.; Similarity: the ORF shows similarity to several serine/threonine-specific protein kinase with different specificities and various cellular functions.; Title: similarity to cdc25C associated protein kinase c-tak1 - Homo sapiens
An18g01830	Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Phenotype: the null mutant of S. cerevisiae DAL5 is viable, but unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae is also called J223,YJR152w or UREp1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae
An18g01840	Function: fcr1 of C. albicans behaves as a negative regulator of drug resistance.; Phenotype: overexpression of fcr1 in the pdr1 pdr3 mutant of S. cerevisiae, which are hypersensitive to fluconazole (FCZ) resulted in increased resistance of the cells to FCZ and cycloheximide and in increased expression of PDR5, a gene coding for a drug efflux transporter of the ATP-binding cassette superfamily.; Similarity: the ORF shows similarity to several zinc finger transcription factors from different species with various function.; Title: similarity to zinc-cluster transcription factor fcr1 - Candida albicans; nucleus; See PMID 9864335
An18g01850	Remark: prostaglandin-endoperoxide synthases are 470 amino acids longer than the predicted ORF.; Similarity: the ORF shows similarity to several prostaglandin-endoperoxide synthases (cyclooxygenase-2) from different species, but the homologues region does not contain the characteristic active site distral histidine and the cyclooxigenase catalytic domain.; Title: weak similarity to prostaglandin-endoperoxide synthase 2 - Rattus norvegicus
An18g01860	Function: nik-1 of N. crassa is a two-component protein, an autophosphorylating histidine kinase and a response regulator, which is probably involved in nutrient deprivation response.; Function: nik-1 of N. crassa is also involved in hyphal development.; Phenotype: deletion of the nik-1+ gene in N. crassa results in an organism that displays aberrant hyphal structure, which is enhanced under conditions of high osmostress.; Remark: no transmembrane domains were predicted,which are usually found in a two-component sensor/response regulator.; Remark: the os-1+ protein is identical to the N. crassa nik-1.; Title: strong similarity to two-component sensor/response regulator nik-1 - Neurospora crassa; plasma membrane; See PMID 8622950; See PMID 10510225
An18g01880	Similarity: the region from amino acid 300 to 360 of the ORF contains a GTP-binding domain (WD, G-beta repeat),which shows similarity to several proteins with different functions, that all express this motive.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina
An18g01890	Similarity: the ORF shows similarity to several glutamic acid-rich proteins and some calcium-binding proteins with unspecified function.; Title: similarity to hypothetical protein K07E12.1 -Caenorhabditis elegans
An18g01910	Similarity: the C-terminal part of the ORF, starting with amino acid 440, shows similarity to a region of the beta transducin-like protein of P. anserina, which contains the GTP-binding domain.; Similarity: the N-terminal part of the ORF, spanning the region from amino acid 14 to 90 is similar to the sequence of gene CG12065 from D. melanogaster and the hypothetical protein H14E04. 2a of C. elegans.; Title: weak similarity to hypothetical protein CAD21096.1 - Neurospora crassa
An18g01920	Function: the ankyrin repeat is one of the most common protein sequence motifs found in a variety proteins with different activities.; Similarity: the predicted ORF shows similarity to ankyrin isoforms from several species, which is due to the presence of ankyrin-repeat homology domain.; Similarity: the similarity to ankryrin repeat domains is located in the C-terminal part of the predicted ORF, starting around amino acid 180.; Title: similarity to ankyrin AAC37208.1 - Drosophila melanogaster; See PMID 7937942
An18g01930	Title: similarity to hypothetical protein encoded by An11g06690 - Aspergillus niger
An18g01950	Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis
An18g01960	Catalytic activity: plsB of E. coli catalyses acyl-CoA + glycerol 3-phosphate = CoA + 1-acyl-glycerol 3-phosphate.; Function: plsB of E. coli catalyzes the first step in de novo phospholipid biosynthesis, the condensation of glycerol-3-phosphate and fatty acid thioesters to yield lysophosphatidic acid; it may also function in the regulation of membrane biogenesis.; Phenotype: E. coli plsB mutants that were conditionally defective in sn-glycerol-3-phosphate acyltransferase activity generated more fatty acids in which glycerol-3-phosphate was not acylated but instead preferentially phosphatidylglycerol.; Remark: plsB of E. coli is also called GPAT, Z5640 or ECS502.; Similarity: the ORF shows similarity to several glycerol-3-phosphate O-acyltransferases from different species.; Title: strong similarity to sn-glycerol-3-phosphate acyltransferase plsB - Escherichia coli; See PMID 3542964; See PMID 6251087; See PMID 6985897
An18g01970	Catalytic activity: panC of C. glutamicum converts ATP + (R)-pantoate + beta-alanine <=> AMP + diphosphate + (R)-pantothenate.; Pathway: panC of C. glutamicum is involved in pantothenate and coenzyme A biosynthesis.; Similarity: the ORF shows similarity to several pantoate--beta-alanine ligases from different species,especially bacteria.; Title: strong similarity to pantoate--beta-alanine ligase panC - Corynebacterium glutamicum
An18g01980	Function: spb4 of S. cerevisiae is involved in the assembly of the ribosomal large subunit and maintenance by regulating the maturation of 25S ribosomal RNA.; Phenotype: aberrant production of 25S ribosomal RNA occurring in spb4-1 mutants of S. cerevisiae.; Remark: YFL002c is a synonym for spb4.; Similarity: the ORF shows similarity to several ATP-dependent RNA helicases and other DEAD box-containing proteins.; Title: strong similarity to ATP-dependent RNA helicase Spb4 - Saccharomyces cerevisiae; nucleus; See PMID 8774901; See PMID 9769101; See PMID 2408148
An18g01990	Remark: the ORF contains WD-repeats, which are found in some eukaryotic proteins with a wide variety of crucial functions.; Title: strong similarity to hypothetical WD-repeat protein SPAC1006.02 - Schizosaccharomyces pombe; See PMID 10322433
An18g02000	Function: rta1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468
An18g02010	Similarity: belongs to the RAD2/XPG family of excision repair endonucleases.; Title: strong similarity to hypothetical excision repair DNase SPAC955.02c - Schizosaccharomyces pombe
An18g02020	Function: tigA of A. niger is thought to be involved in the maturation of secretory proteins.; Gene-ID: tigA; Similarity: tigA of A. niger contains two thioredoxin domains.; endoplasmatic reticulum; See PMID 9256071
An18g02030	Title: similarity to hypothetical protein P0038C05.1 - Oryza sativa
An18g02040	Title: questionable ORF
An18g02050	Similarity: belongs to the 1-aminocyclopropane-1-carboxylate oxidase superfamily.; Similarity: contains an iron/ascorbate oxidoreductase domain.; Title: strong similarity to hypothetical protein 15E6.100 - Neurospora crassa
An18g02060	Function: samB of A. nidulans is involved in the control of polarized growth.; Function: whether samB of A. nidulans regulates polarized growth directly or on the transcriptional level remains uncertain.; Localization: samB of A. nidulans was observed in the cytoplasm in a granular distribution.; Similarity: contains a MYND-type zinc finger domain in the C-terminus.; Title: strong similarity to zinc-finger protein samB - Aspergillus nidulans; See PMID 9427754
An18g02080	Title: weak similarity to nuclear receptor NHR-21a -Caenorhabditis elegans
An18g02090	Complex: sfaD of A. nidulans is the beta-subunit of the heterotrimeric G-protein.; Function: sfaD of A. nidulans is required for normal vegetative growth and repression of sporulation.; Pathway: sfaD of A. nidulans is involved in growth signaling of asexual development.; Title: strong similarity to G-protein beta subunit sfaD - Aspergillus nidulans; See PMID 10523303
An18g02100	Title: weak similarity to hypothetical proline-rich protein At2g14890 - Arabidopsis thaliana
An18g02110	Function: BDM-1 of C. parasitica acts as a positive regulator of G-beta function.; Pathway: BDM-1 of C. parasitica is involved in fungal virulence signaling.; Similarity: belongs to the phosducin superfamily of G-beta modulators.; Title: strong similarity to G-protein beta subunit-interacting protein BDM-1 - Cryphonectria parasitica; See PMID 10618432
An18g02130	Complex: TFG3 of S. cerevisiae forms part of the heterotrimeric TFIIF.; Function: TFG3 of S. cerevisiae is a nonessential stimulating subunit of TFIIF.; Function: TFG3 of S. cerevisiae is identical to ANC1 implicated in actin cytoskeletal assembly and/or function.; Function: TFIIF of S. cerevisiae binds to RNA polymerase II decreasing it's affinity to nonspecific DNA and enabling efficient transcription initiation.; Remark: synonyms for TFG3 from S. cerevisiae are ANC1, TAF30, SWP29 and YPL129w.; Title: strong similarity to small subunit of transcription initiation factor TFIIF Tfg3 - Saccharomyces cerevisiae; nucleus; See PMID 7995524
An18g02140	Function: sbp1p of S. pombe is involved in the control of mitotic exit.; Function: sbp1p of S. pombe regulates spi1p GTPase activity.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the family of Ran-GTPase binding proteins which are implicated in the regulation of nuclear transport, including RNA export into the cytoplasm.; Title: strong similarity to spi1-GTPase binding protein sbp1p - Schizosaccharomyces pombe; See PMID 9504913
An18g02150	Title: similarity to hypothetical protein CAF05965.1 - Neurospora crassa
An18g02160	Title: questionable ORF
An18g02170	Catalytic activity: Ktr5p of S. cerevisiae transfers an alpha-D-mannosyl residue from GDP-mannose to the lipid-linked oligosaccharide precursor.; Function: Ktr5p of S. cerevisiae participates in the formation of the lipid-linked oligosaccharide precursor for N-glycosilation.; Pathway: Ktr5p of S. cerevisiae is involved in the N-glycosilation pathway.; Phenotype: ktr5 mutants of of S. cerevisiae display cell wall defects.; Remark: the systematic gene name of KTR5 of S. cerevisiae is YNL029c.; Similarity: belongs to the KRE2 family of mannosyltransferases.; Title: strong similarity to mannosyltransferase Ktr5 - Saccharomyces cerevisiae; See PMID 9090056; See PMID 9878809
An18g02180	Title: questionable ORF
An18g02190	Title: similarity to hypothetical protein CAC39321.1 - Schizosaccharomyces pombe
An18g02200	Title: strong similarity to lung cancer associated polypeptide SEQ ID NO:723 from patent WO200055180-A2 - Homo sapiens
An18g02210	Catalytic activity: dGTP + H2O = deoxyguanosine + triphosphate.; Function: protein transport. probably involved in vesicular traffic (by similarity).; Remark: Rab7 is a small GTP-ase localized on late endosomes, which regulates late endocytic membrane traffic in mammalian cells. This protein has a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.; Remark: putative sequencing error at position 6018,1 bases too much.; Remark: strong similarity to Aspergillus niger EST AN03A11.; Similarity: to ras proteins. belongs to the rab subfamily.; Title: strong similarity to ras related protein Rab7 - Homo sapiens [putative frameshift]; putative frameshift; See PMID 8954989; See PMID 9126495
An18g02220	Remark: similarity to human GTPase associated protein-22 patent WO200031263-A2.; Title: similarity to GTPase associated protein-22 from patent WO200031263-A2 - Homo sapiens
An18g02230	Complex: Spb1p is associated in vivo with the nucleolar proteins Nop1p and Nop5/58p.; Remark: Spb1p is able to bind [(3)H]AdoMet in vitro,suggesting that it is a methylase.; Remark: Spb1p is required for proper assembly of pre-ribosomal particles during the biogenesis of 60S ribosomal subunits.; Remark: alternative name is YCL054w.; Title: strong similarity to methylase Spb1 -Saccharomyces cerevisiae; See PMID 10648622; See PMID 10556316
An18g02240	Title: similarity to hypothetical protein YML020w -Saccharomyces cerevisiae
An18g02250	Title: strong similarity to hypothetical protein encoded by An01g14540 - Aspergillus niger
An18g02270	Remark: alternative name is YKR019c.; Remark: transcriptional silencing in S. cerevisiae occurs at several genetic loci, including the ribosomal DNA (rDNA). IRS4 is a protein with increased rDNA silencing (irs) phenotype.; Title: similarity to increased rDNA silencing protein Irs4 - Saccharomyces cerevisiae; See PMID 10082585; See PMID 10375630
An18g02280	Remark: Colletotrichum lagenarium and Magnaporthe grisea are plant pathogenic fungi that produce melanin during the appressorial differentiation stage of conidial germination and during the late stationary phase of mycelial growth. CMR1 (Colletotrichum melanin regulation) and PIG1 (pigment of Magnaporthe), that are involved in melanin biosynthesis. Both Cmr1p and Pig1p contain two distinct DNA-binding motifs, a Cys2His2 zinc finger motif and a Zn(II)2Cys6 binuclear cluster motif. The presence of both these motifs in a single transcriptional regulatory protein is unique among known eukaryotic transcription factors. Deletion of CMR1 in C. lagenarium caused a defect in mycelial melanization, but not in appressorial melanization.; Title: strong similarity to melanin regulator CMR1 -Colletotrichum lagenarium; See PMID 11123670
An18g02320	Function: BioF of E. herbicola is involved in the first step of biotin biosynthesis.; Pathway: BioF enzymes are involved in the biotin metabolism.; Similarity: the ORF shows similarity to several pyridoxal-phosphate-dependent aminotransferases.; Title: similarity to 8-amino-7-oxononanoate synthase BioF - Erwinia herbicola; See PMID 11133432
An18g02330	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: C-terminally truncated ORF due to the end of contig.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans [truncated ORF]; nucleus; See PMID 1756977; See PMID 1922075
An18g02340	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: N-terminally truncated ORF due to the end of contig.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans [truncated ORF]; nucleus; See PMID 1756977; See PMID 1922075
An18g02350	Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: the human PPX protein phosphatase could be involved in microtubule organization. It is also suggested to be involved in activation of Rel family transcription factors (c-Rel/NF-kappaB).; Localization: cytoplasmic, nuclear and centrosomes.; Remark: alternate names for the human PPX protein phosphatase: PPP4C or PPP4.; Title: strong similarity to protein phosphatase X PPX - Homo sapiens; See PMID 9837938; See PMID 10769191
An18g02360	Function: S. cerevisiae Alg3 adds the first Dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol.; Pathway: S. cerevisiae Alg3 is involved in the dolichol dependent protein glycosylation in the ER.; Remark: alternate names for S. cerevisiae Alg3: Rhk1 or YBL082C.; Title: strong similarity to Dol-P-Man dependent alpha(1-3) mannosyltransferase Alg3 - Saccharomyces cerevisiae; See PMID 8842708; See PMID 10660594
An18g02370	Title: similarity to hypothetical protein SPBC146.08c - Schizosaccharomyces pombe
An18g02380	Remark: the GluP gene from Brucella abortus strain 2308 was isolated by functional complementation of Escherichia coli strains lacking either glucose or galactose transport systems.; Title: similarity to glucose/galactose transporter GluP - Brucella abortus; See PMID 9168605
An18g02390	Title: questionable ORF
An18g02400	Catalytic activity: ATP + protein <=> ADP + O-phosphoprotein.; Gene-ID: pkcA; deleted EC_number 2.7.1.37; See PMID 8569684
An18g02410	Function: the rat Nopp140 protein is related to nucleologenesis and may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. It may play an important role in transcription catalyzed by RNA polymerase I.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein Nopp140 - Rattus norvegicus; nucleus; See PMID 10679015; See PMID 1623516
An18g02440	Function: the bovine cofactor D is a tubulin-specific chaperone protein involved in the assembly of the alpha/beta-tubulin heterodimers.; Title: strong similarity to tubulin-folding cofactor D - Bos taurus; cytoplasm; See PMID 10831612; See PMID 8706133
An18g02460	Complex: U1A belongs to the spliceosome where it is associated with sn-RNA U1.; Function: the human U1A protein binds to the stem loop II of U1 snRNA. it is the first sn-RNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 sn-RNP and the U4/U6/U5 tri-sn-RNP.; Similarity: the ORF DNA sequence shows also strong similarity to the EST an_3162 from A. niger.; Title: strong similarity to U1 snRNP-specific protein U1A - Homo sapiens; nucleus; See PMID 1833186
An18g02470	Complex: N. crassa Vma-8 belongs to the v-ATPase an heteromultimeric enzyme composed of a peripheral catalytic v1 complex (components A to H) attached to an integral membrane v0 proton pore complex (components: A, C, C', C'' and D).; Function: N. crassa Vma-8 is a subunit of the peripheral v1 complex of vacuolar ATPase (v-ATPase). The V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.; Title: strong similarity to vacuolar ATPase subunit D Vma-8 - Neurospora crassa; vacuole; See PMID 10340846
An18g02480	Function: the human XAB2 protein is involved in transcription-coupled DNA repair.; Title: strong similarity to DNA repair protein XAB2 - Homo sapiens; nucleus; See PMID 10944529
An18g02490	Function: S. cerevisiae Gea2 activates the ARF proteins by exchanging bound GDP for free GTP. Gea1(YJR031C) and Gea2 are functionally interchangeable.; Remark: alternate name for S. cerevisiae Gea2: YEL022W.; Remark: the ADP-ribosylation factor ARF is a small GTP-binding protein that is involved in the transport of vesicles between the endoplasmic reticulum (ER) and Golgi complex and within the Golgi complex itself. ARF cycles between inactive and membrane-associated active forms as a result of exchange of bound GDP for GTP; the GTP-bound form is an essential participant in the formation of transport vesicles.; Title: strong similarity to ARF guanine-nucleotide exchange factor 2 Gea2 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8945477; See PMID 10198630; See PMID 10430582
An18g02500	Remark: blastp with the predicted A. niger protein only retrieves random hits to lysine and glutamic acid rich proteins.
An18g02510	Remark: the genemodel of the predicted A. niger protein shows no obvious possibility to generate two independent ORFs.; Remark: the predicted A. niger protein shows similarity to S. pombe SPAC31A2. 16 in its N-terminal 500 aa, while its C-terminal aa 1200-1350 show similarity to filament proteins.; Title: similarity to hypothetical protein SPAC31A2.16 - Schizosaccharomyces pombe
An18g02520	Title: similarity to hypothetical protein B13N20.300 - Neurospora crassa
An18g02540	Title: weak similarity to protein from patent WO9737044-A1 - Helicobacter pylori
An18g02550	Catalytic activity: dihydroxy-acid dehydratases catalyse the reaction, 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Function: S. cerevisiae ILV3 catalyzes the third step in biosynthesis of branched-chain amino acids.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945
An18g02560	Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450
An18g02580	Remark: blastp with the predicted A. niger protein only retrieves random hits to glutamic acid rich proteins.; Title: weak similarity to hypothetical protein encoded by An12g00890 - Aspergillus niger
An18g02590	Similarity: shows some similarity to several serine/threonine-protein kinases.; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger
An18g02610	Remark: the binding of the spectrin cytoskeleton to the cell plasma membrane depends on the large intracellular attachment protein ankyrin.; Title: similarity to ankyrin AAC37208.1 - Drosophila melanogaster; See PMID 7937942
An18g02630	Title: weak similarity to subtilisin J aprJ -Bacillus stearothermophilus
An18g02640	Title: questionable ORF
An18g02650	Remark: It is suggested that CFP (cercosporin facilitator protein) encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting it, thus maintaining low cellular concentrations of the toxin.; Similarity: shows similarity to several probable drug transport proteins.; Title: similarity to cercosporin transporter -Cercospora kikuchii
An18g02660	Title: questionable ORF
An18g02680	Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431
An18g02690	Remark: dihydrogeodin oxidase catalyzes the regio-and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin.; Similarity: shows also similarity to several laccases, phenol oxidases of different organisms.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus; See PMID 3032923; See PMID 7665560
An18g02700	Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: shows similarity to several cytochrome P450 enzymes.; Title: similarity to cytochrome P-450 cyp509A1 -Cunninghamella elegans; See PMID 10867234
An18g02710	Remark: ent-Kaurene is the first cyclic diterpene intermediate of gibberellin biosynthesis in both plants and fungi.; Remark: in plants, ent-kaurene is synthesized from geranylgeranyl diphosphate via copalyl diphosphate in a two-step cyclization catalyzed by copalyl diphosphate synthase and ent-kaurene synthase.; Title: strong similarity to ent-Kaurene synthase -Phaeosphaeria sp.; See PMID 9268298
An18g02720	Catalytic activity: glutathione S-transferases catalyze the conversion of RX + Glutathione = HX + R-S-Glutathione.; Function: glutathione S-transferases (GST) conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.; Similarity: shows also some similarity to Ure2 of S. cerevisiae, which mediates nitrogen catabolite repression (NCR) of certain yeast genes.; Similarity: shows similarity to several putative glutathione S-transferases.; Title: strong similarity to hypothetical glutathione S-transferase CAA19067.1 - Schizosaccharomyces pombe
An18g02730	Localization: PTH11 of M. grisea was localised as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: similarity to transmembrane protein PTH11 -Magnaporthe grisea; See PMID 10521529
An18g02740	Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: shows similarity to several cytochrome P450 enzymes.; Title: similarity to cytochrome P450 3A7 - Homo sapiens; See PMID 9328287; See PMID 9710705
An18g02750	Title: weak similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides
An18g02752	Title: strong similarity to hypothetical protein BAC47708.1 - Bradyrhizobium japonicum
An18g02760	Similarity: the predicted A. niger protein shows local similarity to the hypothetical protein T21J18. 40 of A. thaliana. this domain is also found in the protein sequence of patent EP1033405-A2 (AC# AAG54045). however,the lengths of these entries differ by 104 amino acids.; Title: similarity to hypothetical protein T21J18.40 - Arabidopsis thaliana
An18g02770	Title: weak similarity to hypothetical protein encoded by An07g09090 - Aspergillus niger
An18g02780	Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; Title: similarity to hypothetical protein encoded by An12g03140 - Aspergillus niger
An18g02800	Regulation: 2'-hydroxyisoflavone reductase from A. thaliana accumulates rapidly in Arabidopsis plants under various oxidative stress conditions, such as treatment with paraquat, t-butylhydroperoxide, diamide, and menadione.; Remark: the protein sequence of 2'-hydroxyisoflavone reductase from A. thaliana is covered by patent EP1033405-A2 (AC# AAG14147). the patent does not provide information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to 2'-hydroxyisoflavone reductase from A. thaliana and from many other plant and fungal species. the N-terminus of the predicted A. niger protein shows strong similarity to a translated mRNA (tomato pathotype-specific DNA fragment) from the fungus Verticillium dahliae.; Title: similarity to 2-hydroxyisoflavone reductase -Arabidopsis thaliana; See PMID 7592828
An18g02820	Title: questionable ORF
An18g02830	Title: strong similarity to hypothetical conserved protein B13N20.310 - Neurospora crassa
An18g02840	Title: strong similarity to hypothetical protein YML079w - Saccharomyces cerevisiae
An18g02850	Function: MRS3 (S. cer.) is essential for the splicing of group II introns and is also involved in processes of mitochondrial biogenesis other than RNA splicing.; Function: MRS3 (S. cer.) may act as a carrier,exerting its suppressor activity via modulation of solute concentrations in the mitochondria.; Function: the MRS3 gene product of S. cerevisiae probably is involved in splicing of aI1 intron for COB gene.; Similarity: the ORF encoded protein is a member of the mitochondrial carrier family.; Title: strong similarity to mtRNA splice defect-suppressing mitochondrial carrier Mrs3 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2448588; See PMID 1703236
An18g02860	Function: NPR1 of S. cerevisiae promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression.; Remark: the systematic name for NPR1 of S. cerevisiae is YNL183C.; Similarity: the predicted A. niger protein shows strong similarity to nitrogen permease reactivator protein (NPR1) from S. cerevisiae. the carboxy-terminal region of NPR1 contains consensus sequences characteristic of the catalytic domains of protein kinases.; Title: strong similarity to nitrogen permease reactivator protein Npr1 - Saccharomyces cerevisiae; See PMID 2125693
An18g02890	Similarity: the predicted A. niger protein shows strong similarity to mitochondrial ribosomal protein L11 from S. cerevisiae and from many eucaryotic species as well as to procaryotic 50S ribosomal proteins L11.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L11 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978
An18g02900	Title: strong similarity to hypothetical protein SPAC8A4.09c - Schizosaccharomyces pombe
An18g02910	Complex: the nucleosome is an octamer containing two molecules of H2a, H2b, H3, and H4; which wrap approximatively 146 bp of DNA.; Function: histone H4, along with histone H3, plays a central role in nucleosome formation.; Similarity: the predicted A. niger protein shows similarity to histone H4 (HHF2) of S. cerevisiae and of many other eucaryotic organisms.; Title: similarity to histone H4 Hhf2 - Saccharomyces cerevisiae; nucleus; See PMID 9256430
An18g02940	Catalytic activity: ciliary dynein beta heavy chain of A. crassispina catalyses the reaction ATP + H(2)O = ADP + phosphate.; Complex: ciliary dynein consists of two heavy chains (alpha and beta), three intermediate chains and several light chains.; Function: ciliary dynein beta heavy chain of A. crassispina is a force generating motor protein of eukaryotic cilia and flagella. it produces force towards the minus ends of microtubules. dynein has ATPase activity.; Regulation: dynein beta heavy chain mRNA of A. crassispina accumulates rapidly in response to deciliation.; Similarity: the predicted A. niger protein shows strong similarity to dynein heavy chains of A. crassispina and of many other eucaryotic organisms.; Title: strong similarity to ciliary dynein beta heavy chain - Anthocidaris crassispina; See PMID 1830928; See PMID 1693885
An18g02950	Remark: SIN1 of A. thaliana is required for normal ovule development. the SIN1 polynucleotide is useful for regulating flowering or fertility in plants. it is also useful for increasing fecundity of plants. the DNA molecule, which plays a vital role in fertility, seed production and flowering time control in plants, is useful as a tool for engineering the expression of genes involved in seed/embryo development and flowering time. it is particularly important in genetically engineering or controlling developmentally important plant processes,which is useful for improving crop plant production.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence short integuments 1 (SIN1) of patent WO200075359-A2 (AC# AAB31166) and several hypothetical RNA helicase of eucaryotic and procaryotic species.; Title: strong similarity to short integuments SIN1 from patent WO200075359-A2 - Arabidopsis thaliana; See PMID 8787738; See PMID 8948599
An18g02960	Complex: the alpha 4 protein of M. musculus binds to murine MB-1 protein and is also tightly associated with a kinase activity. murine MB-1 protein can be co-precipitated with the Ig receptor (IgR). thus, the alpha 4 gene-encoded molecule may be functionally involved in the IgR-mediated signal transduction in B cells.; Remark: the alpha 4 protein of M. musculus is inducibly phosphorylated by stimulation with 12-O-tetradecanoyl-phorbol-13-acetate.; Similarity: the predicted A. niger protein shows similarity to the alpha 4 protein of M. musculus and strong similarity to fungal hypothetical proteins.; Title: similarity to protein alpha 4 - Mus musculus; See PMID 7876543
An18g02970	Catalytic activity: hydroxymethylbilane synthase of S. cerevisiae catalyses the reaction: 4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3).; Cofactor: hydroxymethylbilane synthase of S. cerevisiae requires dipyrromethane as a cofactor.; Pathway: hydroxymethylbilane synthase of S. cerevisiae is the third enzyme in the heme biosynthetic pathway.; Title: strong similarity to hydroxymethylbilane synthase Hem3 - Saccharomyces cerevisiae; See PMID 323256; See PMID 1508149
An18g02980	Catalytic activity: lonD of M. xanthus hydrolyses large proteins such as globin, casein and denaturated serum albumin in presence of ATP.; Function: lonD of M. xanthus degrades short-lived regulatory and abnormal proteins. lonD of M. xanthus is essential for fruiting body formation and development.; Inhibition: lonD of M. xanthus is inhibited by vanadate.; Similarity: the predicted A. niger protein shows strong similarity to endopeptidase La 2 (lonD) of M. xanthus, which belongs to peptidase family S16 also known as the lon family of ATP-dependent proteases.; Title: strong similarity to endopeptidase La 2 lonD - Myxococcus xanthus; cytoplasm; See PMID 8331082; See PMID 8331083
An18g02990	Complex: MRP20 of S. cerevisiae is a component of the 54 S subunit of the yeast mitochondrial ribosome.; Remark: the levels of the mRNAs and proteins for MRP20 is regulated in response to carbon source. in [rho0] strains lacking mitochondrial rRNA, the level of the protein is reduced severalfold, presumably because the unassembled proteins are unstable.; Similarity: the predicted A. niger protein shows similarity to MRP20 of S. cerevisiae, which is similar to members of the L23 family of ribosomal proteins.; Title: similarity to mitochondrial ribosomal protein Mrp20 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1544898
An18g03000	Similarity: the predicted A. niger protein shows strong similarity to hypothetical protein sequences of diverse eucaryotic species and similarity to several procaryotic protein sequences.; Title: strong similarity to hypothetical protein SPBC1703.05 - Schizosaccharomyces pombe
An18g03010	Complex: human p97 also binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor.; Function: human p97 acts as a regulatory subunit of the 26S proteasome, which is involved in the ATP-dependent degradation of ubiquitinated proteins.; Remark: human p97 shows high sequence similarity with a yeast protein of unknown function, which is termed NAS1 (non-ATPase subunit 1, new gene name: RPN1). expression of the human p97 cDNA in nas1 disruptant yeast cells suppressed the growth defect of the mutants. culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.; Remark: the nearly identical human 26S proteasome component P100 protein sequence is covered by patent JP09075082-A (AC# AAW15473).; Similarity: the predicted A. niger protein shows strong similarity to 26S proteasome regulatory subunit S2 (p97) (tumor necrosis factor type 1 receptor associated protein 2) of H. sapiens and other eucaryotic species.; Title: strong similarity to 26S proteasome regulatory subunit S2 - Homo sapiens; endoplasmatic reticulum; See PMID 7601280; See PMID 8774743; See PMID 9584156; See PMID 10664589
An18g03020	Title: similarity to hypothetical protein encoded by MUP24.12 - Arabidopsis thaliana
An18g03030	Complex: in the yeast S. cerevisiae, DNA mismatch repair requires the MSH2, MLH1, and PMS1 proteins. experiments revealed that the yeast MLH1 and PMS1 proteins physically associate, possibly forming a heterodimer, and that MLH1 and PMS1 act in concert to bind a MSH2-heteroduplex complex containing a G-T mismatch. thus,MSH2, MLH1, and PMS1 are likely to form a ternary complex during the initiation of eukaryotic DNA mismatch repair.; Function: disruption of the MLH1 gene of S. cerevisiae results in elevated spontaneous mutation rates during vegetative growth, dramatic increase in the instability of simple sequence repeats and causes increased spore lethality in diploid strains, presumably due to the accumulation of recessive lethal mutations and inefficient repair of heteroduplex DNA generated during genetic recombination.; Similarity: the predicted A. niger protein shows strong similarity to mismatch repair protein MLH1 of S. cerevisiae and other eucaryotic species as well as similarity to the procaryotic DNA mismatch repair protein mutL.; Title: strong similarity to mismatch repair protein Mlh1 - Saccharomyces cerevisiae; See PMID 8066446; See PMID 8264608
An18g03040	Function: XCL100(beta) of X. laevis is able to dephosphorylate both tyrosine and threonine residues of activated p42 MAP kinase in vitro.; Localization: XCL100(beta) proteins were localised predominantly in the nucleus in transfected COS-1 cells.; Regulation: XCL100(beta) of X. laevis is inducible by serum stimulation and oxidative/heat stress in a X. laevis kidney cell line. during early embryogenesis, levels of XCL100 mRNA are greatly increased at the mid-blastula transition, suggesting that this enzyme may be involved in the regulation of MAP kinase activity during early development.; Similarity: the predicted A. niger protein shows similarity to MAP kinase phosphatase XCL100(beta) protein of X. laevis, related proteins from other vertebrate species and from the plant A. thaliana. the predicted A. niger protein shows strong similarity to the probable protein-tyrosine-phosphatase of S. cerevisiae.; Title: similarity to MAP kinase phosphatase XCL100(beta) - Xenopus laevis; nucleus; See PMID 7593328
An18g03060	Function: the human leucine carboxyl methyltransferase LCMT methylates the carboxyl group of the c-terminal leucine residue of protein phosphatase 2a catalytic subunits (PPP2ca) to form alpha-leucine ester residues.; Similarity: the ORF encoded protein also shows strong similarity to the human cell signalling protein-9 from patent WO9958558-A2. The patent does not decribe its function clearly enough.; Similarity: the ORF encoded protein shows strong similarity to the probable S. cerevisiae methyltransferase Ppm2(YOL141w).; Title: similarity to leucine carboxyl methyltransferase LCMT - Homo sapiens; See PMID 10600115
An18g03070	Title: strong similarity to ORF2319 polynucleotide sequence SEQ ID NO:4637 from patent WO200058473-A2 - Homo sapiens
An18g03080	Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516
An18g03090	Title: strong similarity to hypothetical protein SPAC4G8.06c - Schizosaccharomyces pombe
An18g03100	Remark: alternate name for S. cerevisiae Ssp120: YLR250W.; Title: strong similarity to hypothetical precursor of secretory protein Ssp120 - Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 1743509
An18g03110	Similarity: the ORF is longer than H1 of O. cuniculus (730 compared to 606 amino acids). The alignment between the two proteins encompasses about 200 amino acids.; Similarity: the similarities of the ORF encoded protein to matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament triplet protein H1 - Oryctolagus cuniculus
An18g03120	Function: the S. cerevisiae pre-mRNA processing factor Prp43 is involved in disassembly of spliceosomes after the release of mature mRNA.; Remark: alternate name for S. cerevisiae Prp43: YGL120c.; Similarity: the ORF encoded protein and the S. cervisiae Prp43 protein belong to the 'DEAD' box family of helicases.; Title: strong similarity to ATP dependent RNA helicase and pre-mRNA splicing factor Prp43 - Saccharomyces cerevisiae; nucleus; See PMID 9342317
An18g03130	Function: S. pombe Skb1 is a suggested to be protein methyltransferase that positively controls the activity of the Shk1 protein kinase. The p21-activated kinase, Shk1,is required for cell viability, establishment and maintenance of cell polarity, and proper mating response in the fission yeast, Schizosaccharomyces pombe.; Title: strong similarity to shk1 interacting protein skb1p - Schizosaccharomyces pombe; See PMID 8943016; See PMID 9843966; See PMID 11278267
An18g03150	Function: the Podospora anserina cro1 gene is required for sexual sporulation.; Localization: GFP-tagging of the CRO1 protein from Podospora anserina reveals that it is a cytosolic protein mainly expressed at the beginning of the dikaryotic stage and at the time of ascospore maturation.; Title: strong similarity to protein CRO1 - Podospora anserina; cytoplasm; See PMID 9482722
An18g03170	Complex: Pho85(cyclin-dependent kinase)/Pho80(cyclin).; Function: the complex Pho85(cyclin-dependent kinase)/Pho80(cyclin) phophorylates the transcription factor Pho4. Phosphorylation of Pho4 by Pho80-Pho85 turns off PHO5 transcription by regulating the nuclear localization of Pho4.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein and S. cerevisiae Pho85 belong to the Ser/Thr family of protein kinases and to the cdc2/cdkx subfamily.; Title: strong similarity to cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 8539622; See PMID 8918192
An18g03180	Catalytic activity: the human transcription initiation factor TFIIH shows DNA-dependent ATPase activity.; Complex: the human transcription initiation factor TFIIH contains four subunits p89(ERCC3), p80(ERCC2), p52,p35.; Function: TFIIH is involved in RNA polymerase II transcription initiation and in nucleotide excision DNA repair.; Title: strong similarity to subunit of transcription initiation factor TFIIH BTFII - Homo sapiens; nucleus; See PMID 1939143; See PMID 7511595; See PMID 8152490
An18g03190	Catalytic activity: (L-asparaginase) L-asparagine + H(2)O <=> L-aspartate + NH(3).; Similarity: the L-asparaginase from Lupinus arboreus belongs to the asparaginase 2 family.; Similarity: the ORF encoded protein only shows domain homology to the L-asparaginase from Lupinus arboreus. It is strong similar to the 'asparaginase related protein' B17C10. 180 from Neurospora crassa.; Title: similarity to L-asparaginase - Lupinus arboreus; See PMID 1377963
An18g03200	Function: disruption of the act2 gene from S. pombe demonstrated that this gene encodes a function essential for germination of haploid spores.; Title: strong similarity to actin like protein act2p - Schizosaccharomyces pombe; cytoskeleton; See PMID 1729722
An18g03210	Catalytic activity: NADPH + quinone <=> NADP(+) + semiquinone.; Cofactor: Zinc.; Function: quinone oxidoreductases are specific for NADPH and catalyzes the one election reduction of certain quinones substrate. The A. thaliana quinone oxidoreductase P1 also catalyzes the divalent reduction of diamide to 1,2-bis(N,N-dimethylcarbamoyl)hydrazine.; Remark: alternate names for the A. thaliana quinone oxidoreductase P1: NADPH:quinone reductase or Zeta-crystallin.; Title: strong similarity to quinone oxidoreductase P1 - Arabidopsis thaliana; See PMID 11004574; See PMID 3377754
An18g03220	Catalytic activity: S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing thymine.; Remark: alternate names for S. cerevisiae Trm2: Rnc1, Nuc2 or YKR056W.; Title: strong similarity to the tRNA(m5U54)methyltransferase Trm2 - Saccharomyces cerevisiae; See PMID 10864043
An18g03230	Remark: literature about the mitochondrial ribosome structure: Pubmed 11279123.; Similarity: the ORF encoded protein shows strong similarity to the probable mitochondrial ribosomal S5 subunits from S. cerevisiae (MrpS5/YBR251w) and S. pombe (SPAC4G9. 17c).; Title: similarity to ribosomal protein of the small subunit S5 rpsE - Synechococcus sp.; localisation:mitochondrion; See PMID 9300823
An18g03240	Title: similarity to hypothetical protein CAD21178.1 - Neurospora crassa
An18g03250	Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the protein kinase NRC-2 from N. crassa controls the entry of the cell into the asexual developmental program. it is required to repress entry into the conidiation program.; Similarity: the ORF encoded protein and N. crassa NRC-2 belong to the Kin82 subfamily of Ser/Thr protein kinases.; Title: strong similarity to protein kinase NRC-2 -Neurospora crassa; deleted EC_number 2.7.1.37; See PMID 9584090
An18g03270	Remark: the protein sequence described in patent CA2219958-A1 is identical to the sequence of the protein kinase Ste20 from S. cerevisiae, which is involved in regulation of pseudohyphal growth and signal transduction of mating signal.; Title: weak similarity to Ste4p/Gbeta interaction domain of Ste20p/PAK from patent CA2219958-A1 -Unclassified organism
An18g03280	Title: similarity to hypothetical protein B13D24.040 - Neurospora crassa
An18g03290	Function: the PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein shows strong similarity to the S. cervisiae homolog of the p65 PP2A subunit TPD3, which is known to be important for cell cycle, cytoskeleton and cell wall Pubmed 7796803.; Title: strong similarity to regulator subunit of the protein phosphatase 2A PR65 - Xenopus laevis; See PMID 7601134; See PMID 7681822
An18g03300	Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Title: strong similarity to cytosolic phenylalanine--tRNA ligase alpha subunit Frs1 -Saccharomyces cerevisiae; cytoplasm; See PMID 3049607
An18g03310	Function: the S. cerevisiae Rps3 protein is component of the yeast cytosolic 40S ribosomal subunit.; Remark: alternate name for S. cerevisiae Rps3: Suf14, ribosomal protein S3(rp13)(S3), YNL178W.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S3 - Saccharomyces cerevisiae; cytoplasm; See PMID 8670293
An18g03320	Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: human MTM1 is a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It could be involved in a signal transduction pathway necessary for late myogenesis,although its ubiquitous expression suggests a wider function.; Similarity: human MTM1 belongs to the non-receptor class of the protein-tyrosine phosphatase family and to the myotubularin subfamily. The MTM gene subfamily has members in S. pombe, C. elegans, zebrafish, Drosophila, S. cerevisiae mouse and man.; Title: strong similarity to phosphatase myotubularin MTM1 - Homo sapiens; See PMID 8640223; See PMID 9736772
An18g03330	Function: glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating,and in spore release during sporulation. The exo-1,3-beta-glucanase Exg1 from S. cerevisiae enzyme hydrolyzes both 1,3-beta-and 1,6-beta-linkages and even it has beta-glucosidase activity. It could also function biosynthetically as a transglycosylase.; Remark: alternate names for S. cerevisiae Exg1: Bgl1 or YLR300w.; Remark: the alignment of the ORF encoded protein to the S. cerevisiae exo-beta-1,3-glucanase (Exg1/YLR300w) is missing in the blastP-output-list.; Title: similarity to exo-1,3-beta-glucanase Exg1 -Saccharomyces cerevisiae; cell wall; See PMID 9748433; See PMID 3033651
An18g03340	Title: strong similarity to hypothetical protein SPCC1494.08c - Schizosaccharomyces pombe
An18g03350	Title: weak similarity to hypothetical protein AAG17244.1 - Homo sapiens
An18g03360	Similarity: the similarities of the ORF encoded protein to the matching proteins are mainly based on repetitive structures.; Title: similarity to proteophosphoglycan ppg1 -Leishmania major; extracellular/secretion proteins; See PMID 10531342
An18g03380	Function: recombinant S. cerevisiae Trx3 thioredoxin is active in the insulin reduction assay.; Remark: alternate name for S. cerevisiae Trx3: YCR083W.; Title: strong similarity to mitochondrial thioredoxin Trx3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10037727
An18g03400	Title: weak similarity to hypothetical fatty acid alpha-oxidase PIOX - Oryza sativa
An18g03410	Similarity: the ORF DNA sequence shows strong similarity to the EST an_2652 from Aspergillus niger.; Title: weak similarity to protein NUMB-R - Homo sapiens
An18g03420	Similarity: the similarities of the ORF encoded protein to the matching proteins are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein Y51H4A.12 - Caenorhabditis elegans
An18g03430	Title: similarity to EST n1a10a1.r1 - Aspergillus nidulans
An18g03450	Function: protein kfrA of E. aerogenes is a repressor of transcription.; Title: weak similarity to protein kfrA -Enterobacter aerogenes plasmid R751; See PMID 9245806
An18g03460	Title: strong similarity to hypothetical protein SPBC211.05 - Schizosaccharomyces pombe
An18g03470	Function: the S. cerevisiae the tRNA-specific adenosine deaminase Tad1 deaminates adenosine-37 to inosine in tRNA-Ala.; Remark: alternate name for S. cerevisiae Tad1: YGL243W.; Title: similarity to tRNA-specific adenosine deaminase subunit Tad1 - Saccharomyces cerevisiae; See PMID 9707437
An18g03480	Function: the erg-3 protein from N. crassa reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol.; Pathway: the erg-3 protein from N. crassa is involved in the ergosterol biosynthesis.; Title: strong similarity to sterol delta14,15-reductase erg-3 - Neurospora crassa; See PMID 10411271
An18g03490	Function: the bovine mannose 6-phosphate receptor CD-MPR is involved in the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.; Golgi; Remark: alternate names for the bovine mannose 6-phosphate receptor CD-MPR: CD Man-6-P Receptor, MPR 46 or M6PR.; Title: similarity to cation-dependent mannose 6-phosphate receptor precursor CD-MPR - Bos taurus; See PMID 9604938; See PMID 10601243; See PMID 7559753
An18g03530	Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1756977; See PMID 1922075
An18g03540	Title: similarity to hypothetical protein ZK84.2 -Caenorhabditis elegans
An18g03550	Function: the overexpression of ACR3 induced high level arsenite resistance. S. cerevisiae acr3 disruptants are 5-fold more sensitive to arsenate and arsenite than wild-type cells.; Remark: alternate names for S. cerevisiae Acr3: YPR201w or Aar3.; Similarity: the ORF encoded protein also shows strong similarity the Sequence 119 from Patent WO0100804 (Corynebacterium glutamicum), but its function is not clearly enough decribed.; Title: strong similarity to membrane protein involved in arsenite transport Acr3 - Saccharomyces cerevisiae; See PMID 9374482; See PMID 10354596
An18g03560	Title: weak similarity to human protein MLN 51 from patent WO9706256-A2 - Homo sapiens
An18g03570	Function: hydrolyzes beta-glycosidic bond and hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Gene-ID: bgl1; Pathway: involved in cyanoamino acid metabolism; starch and sucrose metabolism and flavonoids, stilbene and lignin biosynthesis.; Remark: an additional blastx reveals that the intergenic region between this ORF and the downstream ORF codes for 3' untranslated region (see trembl:ANI132386).; Similarity: 92-kDa enzyme that is a member of glycosidase family 3.; See PMID 10671536
An18g03580	Remark: an additional blastx search reveals that the intergenic region between this ORF and the upstream ORF codes for 3' untranslated region (see trembl:ANI132386).; Remark: this might be a questionable ORF because gene prediction of 3'exons is difficult.; Similarity: 5'-region shows strong similarity to 3'UTR of beta-glucosidase from A. niger until pos 4497.; Similarity: predicted protein shows weak similarity to inositol phospholipid synthesis protein SCS3 of S. cerevisiae (see MIPS YGL126w).; Similarity: the ORF shows strong similarity to EST of exons 1-7 of beta-glucosidase bgl1 - Aspergillus niger.; Title: similarity to hypothetical protein SPBC543.08 - Schizosaccharomyces pombe; See PMID 10671536
An18g03590	Similarity: shows only partial similarity to C. elegans protein.; Title: weak similarity to hypothetical protein W09B7.d - Caenorhabditis elegans
An18g03600	Function: ereB from E. coli inactivates erythromycin and oleandomycin.; Function: the enzyme of E. coli confers resistance to erythromycin through inactivation by hydrolyzing the lactone ring of the antibiotic.; Remark: truncated ORF due to contig border.; Title: similarity to erythromycin esterase type II ereB - Escherichia coli [truncated ORF]; See PMID 3523438; See PMID 3541783
An18g03610	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611
An18g03620	Similarity: shows only partial similarity to N. crassa protein.; Title: weak similarity to mediator of mating-type associated vegetative incompatibility tol - Neurospora crassa
An18g03630	Similarity: shows weak similarity to GntP family permeases, a family of integral membrane permeases that are involved in gluconate uptake.; Title: similarity to hypothetical protein encoded by An07g02000 - Aspergillus niger
An18g03640	Similarity: shows similarity to aminoterminal part of viral proteins, putatively belongs to transposable elements, viral and plasmid proteins in the funcat.; Title: weak similarity to polymerase-associated nucleocapsid phosphoprotein - Parainfluenza virus type 1
An18g03650	Remark: this region might be destroyed by a transposable element because it only shows parts of similarities.; Similarity: shows similarity to different proteins of various species, but is much shorter.; Title: weak similarity to hypothetical protein CG6066 - Drosophila melanogaster
An18g03660	Function: Prk1 protein kinase of S. cerevisiae regulates the actin cytoskeleton organization by modulating the activities of some actin cytoskeleton-related proteins such as Pan1p/End3p.; Similarity: shows higher similarity to probable serine threonine-protein kinase of S. pombe.; Title: similarity to ser/thr protein kinase Prk1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9885245; See PMID 10087264
An18g03670	Function: Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin,tropomyosin, and calmodulin.; Similarity: blast hits and predicted protein contain long stretches of repetitive sequences and similarity is restricted to these sequences.; Title: similarity to calmodulin- and actin-binding protein h-caldesmon - Gallus gallus; See PMID 2760048
An18g03690	Similarity: shows only similarity at the aminoterminus.; Similarity: shows weak similarity to a keratin domain that is common in avian keratin proteins, found in feathers, scale and claw.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529
An18g03700	Function: P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2.; Similarity: PKR inhibitor is a member of the tetratricopeptide repeat family of proteins, the only member identified thus far with a known biochemical function.; Similarity: predicted protein shows higher similarity to other TPR and DNAJ domain containing proteins and is clearly a member of this family.; Title: similarity to inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) p58 - Bos primigenius taurus
An18g03710	Function: the conventional myosin motor proteins that drive mammalian skeletal and cardiac muscle contraction include eight sarcomeric myosin heavy chain (MyHC) isoforms.; Similarity: shows partial similarity to myosin heavy chain of several species.; Title: similarity to secreted polypeptide #102 from patent WO2003025142-A2 - Homo sapiens
An18g03720	Similarity: blast hits result from repetitive sequences.
An18g03730	Similarity: blast hits mainly result from repetitive sequences.; Title: weak similarity to hypothetical protein CG2779 - Drosophila melanogaster
An18g03740	Function: MKK2 is involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth.; Title: strong similarity to protein kinase of the MAP kinase kinase 2 Mkk2 - Saccharomyces cerevisiae; See PMID 9443897; See PMID 9618441
An18g03750	Remark: truncated ORF due to contig border.; Title: similarity to hypothetical protein 15E6.130 -Neurospora crassa [truncated ORF]
An18g03760	Similarity: the ORF DNA sequence shows also similarity to the A. niger EST an_1616.; Title: strong similarity to hypothetical protein 15E6.130 - Neurospora crassa
An18g03770	Function: the Mot1 protein from S. cerevisiae regulates transcription in association with the TATA binding protein (TBP). It removes TBP from the TATA box in a ATP-dependent manner.; Remark: alternate names for S. cerevisiae Mot1: Bur3, Lpf4 or YPL082C.; Similarity: Mot1 belongs to the Snf2/Rad54 helicase family.; Title: strong similarity to ATPase Mot1 -Saccharomyces cerevisiae; nucleus; See PMID 10887203
An18g03780	Similarity: the ORF encoded protein is also similar to 24 kDa vacuolar protein VP24 of unknown function from Ipomoea batatas (sweet potato), which may be involved in vacuolar transport and/or accumulation of anthocyanin synthesized in the cytosol (Pubmed 11154352;9390439; 11164584).; Title: strong similarity to hypothetical protein 9G6.250 - Neurospora crassa
An18g03790	Function: the S. cerevisiae Grr1 protein is involved in the ubiquitin-dependent degradation of regulatory proteins. This system needs the Skp1p-cullin-F-box protein (SCF) complex.; Remark: alternate names for S. cerevisiae Grr1: Cat80, Cot2, Ssu2 or YJR090C.; Remark: in comparison to the ORF encoded protein the S. cerevisiae Grr1 protein is N-terminally and C-terminally extended.; Title: similarity to protein involved in SCF dependent protein degradation Grr1 - Saccharomyces cerevisiae; See PMID 9891035; See PMID 11259599
An18g03800	Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Pathway: the alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida to metabolize alkanes.; Remark: a splice site was detected upstream of the START codon.; Remark: the alkK gene from Pseudomonas putida complements a fadD (acyl-CoA synthetase) mutation in Escherichia coli.; Title: strong similarity to acyl-CoA synthase AlkK -Pseudomonas putida; See PMID 1453953
An18g03810	Remark: alternate names for S. cerevisiae 60S ribosomal protein L13A: RPL13A, RP22, RPL16A or YIL133C.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L13a - Saccharomyces cerevisiae; cytoplasm; See PMID 3282992
An18g03820	Catalytic activity: palmitoyl-CoA + L-serine <=> CoA + 3-dehydro-D-sphinganine + CO(2).; Cofactor: Pyridoxal-phosphate.; Function: the S. cerevisiae Lcb2 protein catalyzes the first step in the biosynthesis of the long-chain base component of sphingolipids.; Pathway: Lcb2 is involved in the sphingolipid biosynthesis.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Remark: alternate names for S. cerevisiae Lcb2: Scs1, Tsc1 or YDR062W.; Title: strong similarity to serine C-palmitoyltransferase Lcb2 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 1556076; See PMID 8058731; See PMID 8063782
An18g03830	Title: strong similarity to hypothetical protein 9G6.100 - Neurospora crassa
An18g03870	Similarity: the similarity of the ORF encoded protein to the human protein of the DnaJ/Hsp40 family MRJ is limited to N-terminal DnaJ domain.; Title: similarity to DnaJ/Hsp40 family protein MRJ -Homo sapiens; See PMID 10954706
An18g03880	Function: the SalE enzyme from Acinetobacter sp. strain ADP1 was shown to have esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Remark: a salE mutant had lost the ability to utilize only ethyl and methyl salicylates as sole carbon sources.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011
An18g03890	Title: weak similarity to transcription regulator alcR - Aspergillus nidulans
An18g03900	Complex: the prefoldin subunit 2 PFDN2 is organized in a heterohexamer of two PFD-alpha type and four PFD-beta type subunits.; Function: the human prefoldin subunit 2 PFDN2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.; Similarity: the human PFDN2 protein belongs to the prefoldin beta subunit family.; Title: strong similarity to prefoldin subunit 2 PFDN2 - Homo sapiens; cytoplasm; See PMID 9630229
An18g03910	Function: hPrp16 is a ATP-dependent RNA helicase involved in pre-mRNA splicing.; Title: strong similarity to pre-mRNA splicing factor and ATP-dependent RNA helicase hPrp16 - Homo sapiens; nucleus; See PMID 9524131; See PMID 9769096
An18g03920	Function: the mammalian DAD1 protein was identified as a cell death supressor that may act downstream of the bcl-2 protein.; Title: strong similarity to defender against apoptotic cell death DAD1 - Homo sapiens; See PMID 8413235; See PMID 9144178
An18g03930	Similarity: the transcription factor CTFalpha from Fusarium solani belongs to the fungal Cys6Zn2 binucle cluster family.; Title: similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; See PMID 9139694
An18g03940	Function: the Mnn4 protein from S. cerevisiae may function as a positive regulator for mannosylphosphate transferase. It is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.; Remark: the ORF encoded protein is much shorter (299aa) than S. cerevisae Mnn4 (1178aa).; Remark: the S. cerevisiae Mnn4 protein is also described in patent JP09266792-A.; Title: similarity to mannosylphosphorylation protein Mnn4 - Saccharomyces cerevisiae
An18g03950	Remark: the cercosporin toxin resistance protein CRG1 from C. nicotianae is also described patent WO9841082-A1.; Title: strong similarity to cercosporin toxin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336
An18g03960	Title: strong similarity to hypothetical protein YFL034w - Saccharomyces cerevisiae
An18g03970	Remark: the S. cerevisiae SRP40 and the ORF encoded protein are highly repetitive.; Title: similarity to suppressor protein Srp40 -Saccharomyces cerevisiae; See PMID 8702624; See PMID 9364927; See PMID 8083243
An18g03980	Function: the NAALADase from R. norvegicus hydrolyzes acidic peptides, such as the abundant neuropeptide N-acetyl-alpha-L-aspartyl-L-glutamate (NAAG),thereby generating glutamate.; Remark: alternate names for the glutamate carboxypeptidase II from R. norvegicus: NAAG peptidase or N-acetylated alpha-linked acidic dipeptidase (NAALADase).; Similarity: the ORF encoded protein shows also strong similarity to patent WO9735616-A1 (Prostate-specific membrane antigen), the human homologue of the Rat carboxypeptidase II.; Title: strong similarity to glutamate carboxypeptidase II - Rattus norvegicus; See PMID 9375657; See PMID 9501243
An18g03990	Remark: the effect of fluoroquinolone drugs (e. g. norfloxacin) is directed to the DNA gyrase (topoisomerase IV).; Title: similarity to fluoroquinolone resistance factor NorA - Staphylococcus aureus; See PMID 10553699; See PMID 2174864
An18g04000	Title: similarity to hypothetical transmembrane protein SPAP14E8.05c - Schizosaccharomyces pombe
An18g04010	Function: Zep from M. musculus acts as a transcription regulation factor.; Localization: Zep from M. musculus is located in the nucleus.; Title: strong similarity to zinc-finger protein Zep - Mus musculus; nucleus; See PMID 9832628
An18g04020	Remark: C-terminal truncated ORF due to the end of contig.; Remark: the A-band associated protein from Drosophila melanogaster is identical to zetalin a Z-band-associated protein from Drosophila melanogaster.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to A-band associated protein -Drosophila melanogaster [truncated ORF]
An18g04030	Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Remark: the Topoisomerase I (Topo I) from Filobasidiella neoformans is essential.; Similarity: the ORF encoded protein shows really strong similarity to the hypothetical protein SPCC1322. 09 from Schizosaccharomyces pombe.; Title: similarity to Topoisomerase I TopoI -Filobasidiella neoformans; See PMID 10224251
An18g04040	Similarity: the ORF encoded protein shows also similarity to the stationary-phase survival protein surE from Escherichia coli, thus it could be involved in stess response (adaption to stationary-phase; Pubmed 7928962; 9785447).; Title: similarity to alkaline phosphatase from patent WO9748416-A1 - Methanococcus igneus
An18g04060	Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to gastric mucin - Sus scrofa; See PMID 7755593
An18g04070	Function: Balu-42 is differentially expressed in the pellet morphology relative to the filamentous morphology.; Gene-ID: Balu-42
An18g04080	Remark: vanillin-dehydrogenase VDH sequence 27 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid, vanillin, vanillic acid and their applications'.; Title: strong similarity to vanillin-dehydrogenase VDH sequence 27 from patent EP0845532 - Unclassified organism
An18g04090	Title: strong similarity to hypothetical protein encoded by An01g14640 - Aspergillus niger
An18g04100	Similarity: the ORF encoded protein shows strong similarity to the aspergillus oryzae beta-glucosidase gene from patent WO9955884.; Similarity: the gp43 product from P. brasiliensis amino acid sequence showed similarities of 56-58% with exo-1,3- beta-D-glucanases from S. cerevisiae and Candida albicans (EC 3. 2. 1. 58), but however it is devoid of hydrolase activity; Title: strong similarity to 43 kDa secreted glycoprotein precursor gp43 - Paracoccidioides brasiliensis; extracellular/secretion proteins; See PMID 8580684; See PMID 8626811
An18g04110	Remark: Ran GTPase is required for nucleocytoplasmic transport of many types of cargo.; Similarity: it belongs to the RanBP7/importin-beta/Cse1p superfamily; Similarity: the ORF encoded protein shows also strong similarities to many Ranbp11 homologues.; Similarity: the Ranbp11 from human and its homologues are nuclear transport factors, members of karyopherin-beta family.; Title: strong similarity to nuclear transport factor Kap120 - Saccharomyces cerevisiae; See PMID 10684247
An18g04130	Catalytic activity: an aldehyde + NAD(+) + H(2)O <=> an acid + NADH.; Function: the indole-3-acetaldehyde dehydrogenase Iad1 from Ustilago maydis ois involved in the production of the phyto-hormon IndCH2COOH.; Remark: Ustilago maydis is a phytopathogenic fungus.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent WO9506121-A from Cladosporium herbarum.; Title: strong similarity to indole-3-acetaldehyde dehydrogenase Iad1 - Ustilago maydis; See PMID 9022693
An18g04140	Catalytic activity: an orthophosphoric monoester + H(2)O <=> an alcohol + phosphate.; Induction: the expression of this phoA gene from P. chrysogenum is regulated at the transcriptional level and is markedly affected by the inorganic phosphate concentration of the growth medium.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent JP02234681-A.; Title: strong similarity to extracellular acid phosphatase PhoA - Penicillium chrysogenum; extracellular/secretion proteins; See PMID 1563629; See PMID 1909579
An18g04150	Function: the car1 gene of the filamentous fungus Podospora anserina was cloned by complementation of a mutant defective for caryogamy (nuclear fusion), a process required for sexual sporulation.; Title: strong similarity to protein car1 - Podospora anserina; peroxisome; See PMID 7600573
An18g04160	Catalytic activity: 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Pathway: the S. cerevisae ILV3 gene product is involved in the valine, leucine and isoleucine biosynthesis and pantothenate and CoA biosynthesis.; Remark: alternate name for S. cerevisiae Ilv3: YJR016C.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945
An18g04170	Catalytic activity: 5'-phosphopolynucleotide + H(2)O = polynucleotide + orthophosphate (reaction only describes the catalytic activity of matching part of the mouse mRNA capping enzym).; Remark: mammalian capping enzymes are bifunctional proteins with both RNA 5'-triphosphatase and guanylyltransferase activities.; Similarity: the ORF encoded protein shows distinct similarities to two different protein typs. the N-terminus of the ORF matches to hypothetical proteins from S. pombe (e. g. SPAC57A10. 08c). the C-terminus shows similarities to the tyrosine phosphatase domains from some mRNA capping enzyms.; Title: similarity to mRNA capping enzyme MCE - Mus musculus; See PMID 9770468
An18g04180	Remark: alternate names for S. cerevisiae S19 ribosomal protein: 40S ribosomal protein: S16A,YS16,RP55 or YP45. And for the correspondent yeast gene: RP55A,RPS16A or YOL121C.; Similarity: the ORF encoded protein shows the strongest similarity to the S19 ribosomal protein from Emericella nidulans.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S19 - Saccharomyces cerevisiae; cytoplasm; See PMID 6387623; See PMID 6814480
An18g04190	Title: strong similarity to hypothetical protein EAA58949.1 - Aspergillus nidulans
An18g04200	Function: the formyl-CoA transferase frc from Oxalobacter formigenes catalyzes the transfer of CoA from formyl-CoA to either oxalate or succinate.; Pathway: in Oxalobacter formigenes oxalic acid, a highly toxic by-product of metabolism, is catabolized by utilizing an activation-decarboxylation reaction which yields formate and CO2. The formyl-CoA transferase frc is involved at this detoxification step.; Title: similarity to formyl-CoA transferase frc -Oxalobacter formigenes; See PMID 9150242; See PMID 2361939
An18g04210	Complex: the Stb3 protein binds to the pleiotropic S. cerevisiae transcriptional repressor Sin3.; Title: similarity to SIN3 protein-binding protein Stb3 - Saccharomyces cerevisiae; nucleus; See PMID 9393435; See PMID 11028908
An18g04220	Function: the mitochondrial ADP/ATP carrier ANC1 from Schizosaccharomyces pombe catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.; Title: strong similarity to mitochondrial ADP/ATP carrier anc1p - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 8675018
An18g04230	Complex: the S. cerevisiae Kri1 protein was found to be in a complex with Krr1.; Function: both proteins S. cervisiae Kri1 and Krr1 are required for 40S ribosome biogenesis in the nucleolus.; Remark: Kri1='Krr1 interacting protein'.; Remark: alternate name for S. cerevisiae Kri1: YNL308C.; Title: strong similarity to protein involved in ribosome biogenesis Kri1 - Saccharomyces cerevisiae; nucleus; See PMID 11027267
An18g04240	Complex: the Sip3 protein from S. cerevisae interacts with the famous protein kinase of the carbon source signal transduction pathway Snf1.; Remark: Sip3 from S. cerevisae is able to stimulate transcription.; Remark: alternate name for S. cerevisiae Sip3: YNL257c.; Similarity: the Sip3 protein contains a putative leucine zipper motif, thus it could be a putative transcription factor.; Title: strong similarity to Snf1 interacting protein Sip3 - Saccharomyces cerevisiae
An18g04250	Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to laminin A Lam-A - Drosophila melanogaster; extracellular/secretion proteins; See PMID 8223265; See PMID 1744083
An18g04260	Localization: the proteins, which are showing a strong similarity to the ORF encoded protein e. g. S. cerevisiae YPL244c are probable membrane proteins.; Similarity: the ORF encoded portein shows strong similarities to some probable UDP-galactose transporters.; Title: similarity to secreted protein HNTME13 from patent WO9839446-A2 - Homo sapiens; extracellular/secretion proteins
An18g04270	Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0).; Function: peptidyl prolyl cis/trans isomerase HPAR14 from human catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Similarity: HPAR14 from H. sapiens is a parvulin-like peptidyl prolyl cis/trans isomerase.; Title: strong similarity to peptidyl-prolyl cis/trans isomerase HPAR14 - Homo sapiens; See PMID 10100858
An18g04280	Title: strong similarity to hypothetical protein CG6144 - Drosophila melanogaster
An18g04290	Remark: alternate name for S. cerevisiae Dfg10: YIL049w.; Remark: diploid S. cerevisiae strains starved for nitrogen undergo a developmental transition from growth as single yeast form (YF) cells to a multicellular form consisting of filaments of pseudohyphal (PH) cells.; Remark: the DFG10 gene was found in a screen for mutant strains defective for filamentous growth.; Title: similarity to protein required for filamentous growth, cell polarity, and cellular elongation Dfg10 - Saccharomyces cerevisiae; See PMID 9055077
An18g04300	Function: h-caldesmon from Gallus gallus plays a vital role in the regulation of smooth muscle and nonmuscle actin-myosin interaction; Remark: Gallus gallus=chicken.; Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to h-caldesmon - Gallus gallus; cytoskeleton; See PMID 2760048
An18g04310	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S12 - Sus scrofa; cytoplasm; See PMID 7622064
An18g04320	Function: the Vid24 protein from S. cerevisiae is involved in vacuolar targeting of fructose-1,6-bisphosphatase (FBPase) containing vesicles. Vid24p dependent protein sorting is probably mediated by the ubiquitin conjugating system.; Remark: alternate name for S. cerevisiae Vid24: YBR105c.; Title: similarity to protein involved in vacuolar protein targeting Vid24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9508768
An18g04330	Remark: Homoserine lactone-dependent synthesis of sigma s in E. coli can be prevented by overexpression of RspA.; Remark: the expression of sigma s (the E. coli stress specific sigma factor) is induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis.; Similarity: the RspA protein from E. coli shows also similarities to some cycloisomerases.; Title: strong similarity to starvation-sensing protein rspA - Escherichia coli; See PMID 7545940
An18g04340	Catalytic activity: uridine + H(2)O <=> uracil + D-ribose.; Remark: alternate name for S. cerevisiae Urh1: YDR400w.; Title: strong similarity to uridine nucleosidase Urh1 - Saccharomyces cerevisiae; See PMID 10501935
An18g04350	Title: similarity to hypothetical protein SPAC5D6.07c - Schizosaccharomyces pombe
An18g04360	Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: weak similarity to zinc-finger protein RIZ -Homo sapiens; See PMID 8643684; See PMID 10706618
An18g04365	Title: weak similarity to deubiquitinating enzyme UBPY - Mus musculus
An18g04400	Remark: the DRG gene from Xenopus laevis is highly expressed in the embryonic CNS.; Similarity: the ORF encoded protein belongs to a group of very storg conserved proteins DRG (X. laevis,mouse, rat, human) and Fun11 (S. cerevisiae), which function is still unclear.; Title: strong similarity to GTP-binding protein DRG - Xenopus laevis; See PMID 8179998; See PMID 10760581
An18g04410	Catalytic activity: L-cysteine + O(2) <=> 3-sulfinoalanine.; Cofactor: iron.; Pathway: the cysteine dioxygenase CDO1 from Rattus norvegicus the cysteine metabolism and Taurine and hypotaurine metabolism.; Title: strong similarity to cysteine dioxygenase CDO1 - Rattus norvegicus; See PMID 9654352; See PMID 2334417
An18g04420	Catalytic activity: UDP-glucose + glycogenin <=> UDP + glucosylglycogenin.; Complex: the human glycogenin is sub-unit of the glycogen synthase.; Similarity: the ORF encoded protein is c-terminal extended in comparison to its homologues.; Similarity: the ORF encoded protein shows similarity to the Caenorhabditis elegans glycogenin described in patent WO9850553-A1.; Title: similarity to glycogenin 1 GYG - Homo sapiens; See PMID 8602861; See PMID 10644553
An18g04430	Catalytic activity: an epoxide + H(2)O <=> a glycol.; Title: similarity to soluble epoxide hydrolase sEH clone EH3.1 - Solanum tuberosum; See PMID 7920715; See PMID 8678300
An18g04440	Function: Filobasidiella neoformans produces a thick extracellular polysaccharide capsule, which is well recognized as a virulence factor. CAP10 from Filobasidiella neoformans is required for capsule formation.; Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503
An18g04450	Title: similarity to hypothetical protein encoded by An11g07910 - Aspergillus niger
An18g04460	Title: strong similarity to hypothetical protein B2O8.250 - Neurospora crassa
An18g04470	Function: S. cerevisiae Tbf1 binds to TTAGGG repeats. It essential for cell growth and may play a role in telomere function and/or structure. It may regulate gene expression.; Remark: alternate names for S. cerevisiae Tbf1: Lpi16 or YPL128C.; Title: strong similarity to TTAGGG repeat binding factor Tbf1 - Saccharomyces cerevisiae; nucleus; See PMID 8423796; See PMID 10871401
An18g04480	Complex: the human TAFII30 protein belongs to the basic RNAPolII transcription factor TFIID. TFIID is composed of TATA Binding Protein (TBP) and a number of TBP-associated factors (TAFs).; Function: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Title: strong similarity to subunit of transcription initiation factor TFIID TAFII30 - Homo sapiens; nucleus; See PMID 7923369
An18g04490	Function: the E. coli S19 ribosomal subunit forms a complex with S13 that binds strongly to the 16S ribosomal RNA.; Similarity: the ORF encoded protein shows strong similarity to the probable mitochondrial ribosomal S19 proteins from S. cerevisiae (YNR037c) and S. pombe (SPAC1751. 02c).; Title: similarity to ribosomal protein of the small subunit s19 rpsS - Escherichia coli; localisation:mitochondrion; See PMID 348496
An18g04520	Function: the S. cerevisiae transcriptional regulator Arg82 also has inositol polyphosphate multikinase (ipmk) activity, it is still unclear how this activity is involved in the regulatory network.; Remark: alternate names for S. cerevisiae Arg82: ArgRIII, Ipk2 or YDR173C.; Title: similarity to regulator protein of the arginin metabolism Arg82 - Saccharomyces cerevisiae; nucleus; See PMID 10632874; See PMID 11119723; See PMID 2274024; See PMID 3298999
An18g04530	Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to hypothetical protein SPAC13F5.10 - Schizosaccharomyces pombe [truncated ORF]
An18g04540	Catalytic activity: NADPH + quinone <=> NADP(+) + semiquinone.; Remark: the E. coli QOR protein is the homolog of the mammalian zeta-crystallin which has NADPH:quinone reductase activity and which is also an important structual component of the eye-lens.; Title: strong similarity to quinone oxidoreductase QOR - Escherichia coli; See PMID 7602590
An18g04550	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from yeast and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An18g04560	Catalytic activity: N-acetyl-D-glucosamine + H(2)O <=> D-glucosamine + acetate.; Remark: Pneumococci in which pgdA was inactivated produce fully N-acetylated glycan and become hypersensitive to exogenous lysozyme in the stationary phase of growth.; Title: similarity to peptidoglycan GlcNAc deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617
An18g04570	Complex: the S. cerevisiae Clp1 protein is part of the cleavage factor IA complex involved premessenger RNA 3'-end formation which also contains Rna14, Rna15, Pcf11 and the major poly(A)-binding protein Pab1.; Remark: alternate name for S. cerevisiae Clp1: YOR250C.; Title: strong similarity to cleavage/polyadenylation factor IA subunit Clp1 - Saccharomyces cerevisiae; nucleus; See PMID 9223284
An18g04580	Remark: the ORF encoded protein shows repetitive structures.; Title: similarity to neurofilament polypeptide H -Oryctolagus cuniculus; See PMID 1512270
An18g04590	Function: Rdi1 from S. cerevisiae regulates the GDP/GTP exchange reaction of the rho-type G-proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.; Remark: alternate name for S. cerevisiae Rdi1: YDL135C.; Title: strong similarity to rho GDP dissociation inhibitor Rdi1 - Saccharomyces cerevisiae; See PMID 8051050; See PMID 9242378
An18g04600	Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Remark: alternate names for S. cerevisiae Ppg1: PPG or YNR032W.; Similarity: S. cerevisiae Ppg1 belongs to the PPP family of phosphatases and to the PP-2a subfamily.; Title: strong similarity to catalytic chain of the phosphoprotein phosphatase PPG Ppg1 - Saccharomyces cerevisiae; See PMID 7678255
An18g04610	Complex: the 'Assembly Protein Complex 3' (AP-3) is a heterotetramer composed of two large chains (delta and beta3=beta-NAP), a medium chain (mu3) and a small chain (sigma3).; Function: the human beta-NAP protein is part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. This complex is associated with the golgi region as well as more peripheral structures. Beta-NAP facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.; Remark: alternate names for the human neuron-specific vesicle coat protein beta-NAP: beta-adaptin 3b or AP-3 complex beta3b subunit.; Title: strong similarity to neuron-specific vesicle coat protein and cerebellar degeneration antigen beta-NAP -Homo sapiens; intracellular transport vesicles; See PMID 767130
An18g04620	Function: the MCT3 transporter from Rattus norvegicus is a proton-linked monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate,branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,beta-hydroxybutyrate and acetate.; Title: strong similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; plasma membrane; See PMID 9632638; See PMID 9841555
An18g04630	Remark: alternate name for S. cerevisiae Trp5: YGL026C.; Similarity: the ORF encoded protein only shows significant similarity to the C-terminal part of the S. cerevisiae Trp5 product (also to its homologs). The homology to Trp5 does not extent upstream of the startcodon. The ORF seems to encode a strong shorter version of a Trp5-like tryptophan synthase. Surprisingly N. crassa also has a shorter version of a TRP5-like gene which encodes a protein of a comparable length (TREMBL:AF084905_1; 138 AA).; Title: similarity to tryptophan synthase Trp5 -Saccharomyces cerevisiae; See PMID 6276387; See PMID 6381966
An18g04640	Function: S. cerevisiae Nuf2 is a spindle pole body-associated protein required for nuclear division. It is involved in spindle pole body separation and spindle elongation.; Remark: alternate name for S. cerevisiae Nuf2: YOL069W.; Title: strong similarity to spindle pole body protein Nuf2 - Saccharomyces cerevisiae; centrosome; See PMID 8188751
An18g04650	Complex: S. cerevisiae Gcn3 is component of the GCD complex with five different subunits; alpha (Gcn3), beta (Gcd7), gamma (Gcd1), delta (Gcd2) and epsilon (Gcd6).; Function: S. cerevisiae Gcn3 is nonessential component of the high-molecular-weight GCD complex which activates the synthesis of Gcn4 (transcription factor) in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of Gcn4 expression depending on amino acid availability. The modulation of Gcn3 regulatory function in response to amino acid availability occurs posttranslationally.; Remark: alternate names for S. cerevisiae Gcn3: Aas2 or YKR026C.; Similarity: S. cerevisiae Gcn3 belongs to the eIf-2b alpha/beta/delta subunits family.; Title: strong similarity to guanine nucleotide exchange factor eIF-2B 34 kDa alpha subunit Gcn3 -Saccharomyces cerevisiae; cytoplasm; See PMID 8506384; See PMID 3062370
An18g04660	Catalytic activity: acyl-CoA + cholesterol <=> CoA + cholesterol ester.; Remark: alternate names for S. cerevisiae Sat1: Are2 or YNR019W.; Title: strong similarity to sterol o-acyltransferase Sat1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8650549; See PMID 8798656; See PMID 10672016
An18g04670	Golgi; Localization: expression of the human transporter cDNA in CHO-K1 cells in its native and in a C-terminally HA-tagged form indicated that the human UDP-GlcNAc transporter was localized in the Golgi apparatus.; Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST m6g08a1. r1.; Title: similarity to UDP-N-acetylglucosamine transporter SLC35A3 - Homo sapiens; See PMID 10393322
An18g04680	Remark: blast results are not significant.; Title: weak similarity to hypothetical nonstructural protein V - Newcastle disease virus
An18g04690	Localization: mastermind accumulates predominantly in the nucleus.; Remark: mastermind of D. virilis is a neurogenic gene which is required for proper partitioning of ectodermal cells into epidermal versus neural lineages.; Remark: nearly half of the protein sequence of mastermind consists of only three amino acids: glutamine,glycine, and asparagine.; Similarity: blast hits result from repetitive sequences, ORF might be to long.; Title: similarity to protein mastermind - Drosophila virilis; nucleus; See PMID 1701150
An18g04710	Remark: blast hits result from repetitive seq.; Title: weak similarity to hypothetical retinitis pigmentosa GTPase regulator RPGR - Homo sapiens
An18g04720	Remark: the ORF is short in length (35 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An18g04730	Title: strong similarity to hypothetical protein SPCC622.11 - Schizosaccharomyces pombe
An18g04740	Title: questionable ORF
An18g04750	Similarity: weak similarity to apolipoprotein A-IV I isoform of Papio hamadryas.; Title: strong similarity to hypothetical protein 8D4.210 - Neurospora crassa; See PMID 8101842
An18g04770	Remark: blast hits result from repetitive sequences.
An18g04780	Title: similarity to hypothetical protein 68B2.200 -Neurospora crassa
An18g04790	Function: acts as glutathione-disulfide oxidoreductase in the presence of NADPH and glutathione reductase and reduces low molecular weight proteins and disulfides.; Title: strong similarity to thioltransferase glutaredoxin - Oryza sativa; See PMID 8287970
An18g04800	Remark: rhaA of A. aculeatus hydrolyzes alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Remark: the ORF is longer than rhaA of A. aculeatus (1131 compared to 660 amino acids).; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105
An18g04810	Title: strong similarity to exo-polygalacturonase PGX from patent WO9414966-A - Aspergillus tubingensis; cytoplasm; See PMID 8856078
An18g04830	Remark: gene structure questionable; Title: questionable ORF
An18g04840	Function: translation elongation, protein biosynthesis.; Remark: possible sequencing error.; Title: strong similarity to translation elongation factor 1 alpha - Podospora anserina [putative sequencing error]; cytoplasm; See PMID 8289244
An18g04850	Complex: hRPC11 is a small, essential subunit RNA polymerase III. hRPC11 is specific for PolIII.; Function: RNA polymerase III deprived of hRPC11,initiates transcription properly but ignores pause sites and is defective in termination. Pol III delta lacks the intrinsic RNA cleavage activity of complete Pol III.; Similarity: the predicted A. niger protein shows strong similarity to human RNA polymerase III subunit (hRPC11) and related highly conserved proteins.; Title: strong similarity to RNA polymerase III subunit hRPC11 - Homo sapiens; nucleus; See PMID 9869639
An18g04870	Title: weak similarity to death-associated protein kinase DAPK - Homo sapiens; See PMID 7828849
An18g04880	Title: similarity to hypothetical protein SPCC645.04 - Schizosaccharomyces pombe
An18g04910	Title: similarity to monocarboxylate transporter MCT2 - Rattus norvegicus; See PMID 9182702
An18g04930	Title: similarity to secreted protein yb7_1 - Homo sapiens
An18g04960	Remark: Similarity possibly caused by structural domain.; Title: weak similarity to hypothetical protein Y54E5A.7 - Caenorhabditis elegans
An18g04970	Title: weak similarity to subtilisin E precursor aprE - Bacillus subtilis
An18g05000	Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to host infection protein cap20 - Colletotrichum gloeosporioides; See PMID 7756829
An18g05020	Remark: belongs to the 60S large ribosomal subunit.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Rpl27 - Saccharomyces cerevisiae; cytoplasm; See PMID 10590466
An18g05040	Function: the golgin family of coiled-coil proteins function in Rab6-regulated membrane-tethering events.; Golgi; Localization: human golgin proteins target to the Golgi apparatus through a carboxy-terminal domain containing a conserved tyrosine residue, which is critical for targeting.; Similarity: the predicted A. niger protein shows strong similarity to human golgin 245 and similarities to several coiled-coil proteins, e. g. human centromere protein E, human giantin and myosin heavy chains of different organisms.; Title: strong similarity to golgin-245 - Homo sapiens; See PMID 8537393; See PMID 10209123
An18g05050	Title: strong similarity to hypothetical protein encoded by B7F18.130 - Neurospora crassa
An18g05060	Remark: similarity to component of human SWI/SNF-like chromatin-remodeling protein complexes; Title: strong similarity to SWI/SNF-related,matrix-associated, actin-dependent regulator of chromatin SMARCD1 - Homo sapiens; See PMID 8804307
An18g05070	Title: strong similarity to 26S proteasome subunit 9 - Homo sapiens; cytoplasm; See PMID 9119060
An18g05080	Remark: SOF1 yeast protein is involved in rRNA processing. Protein shows also considerable similarity to 3-ISOPROPYLMALATE DEHYDROGENASE of S. pombe.; Title: strong similarity to protein Sof1 -Saccharomyces cerevisiae; nucleus; See PMID 8508778
An18g05090	Remark: Similarity to murine short-chain dehydrogenase/reductase that reduces all-trans-retinal in cone photoreceptors.; Title: similarity to retinal short-chain dehydrogenase/reductase retSDR1 - Mus musculus; See PMID 9705317
An18g05100	Title: similarity to cytosine deaminase codA -Escherichia coli; See PMID 8450832
An18g05110	Title: weak similarity to polycomblike protein XPcl2 - Xenopus laevis
An18g05120	Function: bbsF of T. aromatica is part of the bbs operon, encoding enzymes of beta oxidation of the toluene catabolism intermediate benzylsuccinate.; Pathway: bbsF of T. aromatica is a component of the anaerobic toluene catabolism.; Title: strong similarity to subunit of succinyl-CoA:benzylsuccinate CoA-transferase bbsF - Thauera aromatica; See PMID 10629170
An18g05130	Remark: Carboxyterminal perhapes shorter; Title: strong similarity to riboflavin synthase Rib5 - Saccharomyces cerevisiae; See PMID 7814407
An18g05140	Remark: putative role in mating.; Title: strong similarity to hypothetical protein Ssf1 - Saccharomyces cerevisiae
An18g05150	Function: RRP3 (rRNA processing) of S. cerevisiae is required for pre-rRNA processing.; Title: strong similarity to RNA helicase-like protein Rrp3 - Saccharomyces cerevisiae; See PMID 8774901
An18g05160	Remark: fragment, but sequence so far obtained shows high similarity. Aminoterminus is lacking. Enzyme converts N-acetyl-D-glucosamine 1-phosphate to N-acetyl-D-glucosamine 6-phosphate.; Title: strong similarity to phosphoacetylglucosamine mutase AGM1 - Candida albicans [truncated ORF]; See PMID 8119301
An18g05170	Catalytic activity: N-acetyl-D-glucosamine 1-phosphate -> N-acetyl-D-glucosamine 6-phosphate.; Induction: AGM1 is activated by N-acetyl-D-glucosamine 1,6-bisphosphate.; Pathway: AGM1 of C. albicans is involved in aminosugars metabolism.; Remark: AGM1 of C. albicans belongs to the phosphohexose mutase family.; Title: similarity to phosphoacetylglucosamine mutase AGM1 - Candida albicans; See PMID 11004509
An18g05180	Title: strong similarity to hypothetical membrane protein YCR044c - Saccharomyces cerevisiae
An18g05190	Function: ODP1 can catalyze both the mono- and asymmetric dimethylation in S. cerevisiae.; Function: ODP1 methylates arginines in a variety of RNA-binding proteins in S. cerevisiae.; Remark: alternate names in S. cerevisiae = RMT1,HMT1, HCP1, YBR0320, YBR034c.; Title: strong similarity to protein Odp1 -Saccharomyces cerevisiae; See PMID 8647869
An18g05210	Remark: the trifunctional protein consists of 2-Enoyl-CoA hydratase (EC 4. 2. 1. 17), L-3-hydroxyacyl-CoA dehydrogenase (EC 1. 1. 1. 35), and 3-hydroxyacyl-CoA epimerase (EC 5. 1. 2. -) in Neurospora crassa.; Title: similarity to multifunctional beta-oxidation protein - Neurospora crassa; See PMID 1830048
An18g05220	Function: gamma-butyrobetaine hydroxylase catalyzes the hydroxylation of gamma-butyrobetaine to carnitine, the last step in the biosynthesis of carnitine from lysine in Pseudomonas.; Title: strong similarity to gamma-butyrobetaine hydroxylase - Pseudomonas sp.; See PMID 1988434
An18g05230	Function: the S. cerevisiae homolog Rpt5p is subunit of the 20S proteasome regulatory particle.; Remark: proteasomes are maily localised in the in the nuclear envelope-ER network.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt5 - Saccharomyces cerevisiae
An18g05270	Catalytic activity: STY1 in Schizosaccharomyces pombe is activated by tyrosine and threonine phosphorylation (by similarity).; EC:2.7.1.-; Title: strong similarity to mitogen-activated protein kinase sty1p - Schizosaccharomyces pombe; See PMID 8557102; See PMID 10428498
An18g05280	Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger
An18g05290	Remark: the ORF is short in length (63 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF
An18g05340	Title: similarity to hypothetical protein CAD70913.1 - Neurospora crassa
An18g05350	Remark: blastp hits are random.
An18g05360	Remark: blastp hits are random.
An18g05380	Function: the sck1 gene from S. pombe is able to suppress the defects conferred by a mutation in any of these git genes.; Function: the sck1 gene from S. pombe was cloned as a high copy number suppressor of a mutation in git3 (components of an adenylate cyclase activation pathway).; Title: strong similarity to cAMP-dependent protein kinase sck1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 7498728
An18g05400	Remark: blastp hits are random or based on repetetive sequence motives.
An18g05410	Remark: blastp hits are random; Title: questionable ORF
An18g05420	Title: similarity to nuclear localization protein Npl6 - Saccharomyces cerevisiae; See PMID 8514125
An18g05430	Function: SNF7 of S. cerevisiae is required for normal morphology and sorting activity of the endosome.; Phenotype: mutations of SNF7 in S. cerevisiae prevent full depression of the SUC2 (invertase) gene in response to glucose limitation and result in a sporulation defect in homozygous diploids.; Remark: the major functional role of SNF7 in S. cerevisiae may be related to invertase expression or glucose repression.; Title: strong similarity to endosomal protein Snf7 -Saccharomyces cerevisiae; endosome; See PMID 8224817; See PMID 9606181; See PMID 11251082
An18g05440	Remark: blastp hits are random.
An18g05450	Remark: alternate name in S. cerevisiae = YLL028w.; Remark: it is indicated that a membrane protein encoded by YLL028w (TPO1) is a polyamine transport protein on the vacuolar membrane in S. cerevisiae.; Title: similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; See PMID 9920864; See PMID 11171066
An18g05470	Catalytic activity: 3-beta-hydroxy-delta5-steroid + nad+ = 3-oxo-delta5 -steroid + nadh (acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-dione and on 3-beta-hydroxypregn -5-en-20-one to form progesterone).; Remark: alternate name in S. cerevisiae = YGL001C.; Title: similarity to C-3 sterol dehydrogenase Erg26 - Saccharomyces cerevisiae; See PMID 9811880
An18g05480	Catalytic activity: oxidation of methanol into formaldehyde and H2O2.; Function: P. pastoris, contains two alcohol oxidase genes, AOX1 and AOX2.; Function: in methylotrophic yeasts, alcohol oxidase is the first enzyme in the methanol-utilization pathway.; Similarity: show strong similarity to several fungal alcohol oxidases.; Title: strong similarity to alcohol oxidase AOX1 -Pichia pastoris; See PMID 2660463
An18g05490	Similarity: shows also similarity to corresponding human hypothetical gene product DAM1.; Title: similarity to hypothetical protein T12A2.7 -Caenorhabditis elegans
An18g05500	Function: active in neutral to alkaline range.; Function: human enzyme cleaves lipid ceramide into free fatty acid and sphingosine.; Localization: might be mitochondrial.; Title: strong similarity to mitochondrial ceramidase AAF86240.1 - Homo sapiens
An18g05510	Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive sequences.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942
An18g05540	Title: similarity to hypothetical protein B13D15.090 - Neurospora crassa
An18g05550	Function: DL-2-Haloacid dehalogenase from Pseudomonas sp. strain 113 (DL-DEX) catalyzes the hydrolytic dehalogenation of both D- and L-2-haloalkanoic acids to produce the corresponding L- and D-2-hydroxyalkanoic acids, respectively, with inversion of the C2 configuration.; Function: DL-DEX is a unique enzyme that acts on the chiral carbon of the substrate and uses both enantiomers as equivalent substrates.; Title: similarity to L-2-haloalkanoic acid dehalogenase hadL - Pseudomonas putida; See PMID 9209038
An18g05560	Similarity: blast hits cover only carboxyterminal part of the ORF.; Title: weak similarity to hypothetical conserved protein DR2483 - Deinococcus radiodurans
An18g05570	Catalytic activity: the E. coli enzyme catalyzes the hydrolysis of GTP in a ribosome-dependent manner.; Function: it protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.; Similarity: shows strong similarity to fungal IF2 in mitochondria, but is about 200 bp longer and is perhapes not localized in mitochondria.; Title: strong similarity to translation initiation factor IF2 infB - Escherichia coli
An18g05580	Similarity: blast hits result from repetitive sequences.
An18g05590	Title: strong similarity to mitochondrial carrier protein Ymc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9559855
An18g05600	Similarity: shows similarity to proteins containing Fungal Zn(2)-Cys(6) binuclear cluster domains i. e. mainly transcriptional regulatory proteins.; Title: weak similarity to hypothetical transcriptional regulator FCR1 - Candida albicans
An18g05610	Similarity: member of the allantoate family of the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 3275614
An18g05620	Function: glucosidase II is an ER heterodimeric enzyme that cleaves sequentially the two innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on nascent glycoproteins.; Function: this processing allows the binding and release of monoglucosylated (Glc(1)Man(9)GlcNAc(2)) glycoproteins with calnexin and calreticulin, the lectin-like chaperones of the endoplasmic reticulum.; Similarity: family 31 comprises of enzymes that are,or similar to, alpha- galactosidases.; Title: strong similarity to glucosidase II alpha subunit AAF66685.1 - Homo sapiens; See PMID 10929008
An18g05630	Similarity: ribosomal S2 proteins have been shown to belong to a family that includes 40S ribosomal subunit 40kD proteins, putative laminin-binding proteins, NAB-1 protein and 29. 3Kd protein from Haloarcula marismortui.; Title: similarity to mitochondrial ribosomal protein of the small subunit S2 Mrp4 - Saccharomyces cerevisiae; See PMID 1531984
An18g05640	Similarity: shows also similarity to probable nitrogen starvation-induced glutamine rich protein of C. gloeosporioides.; Title: strong similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus
An18g05650	Function: drosophila protein is important in the structural and functional integrity of the sperm tail.; Similarity: similarity only partial.; Title: similarity to sperm tail-specific protein mst101 - Drosophila hydei; See PMID 7957199
An18g05670	Function: NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of S. tuberosum.; Title: strong similarity to 23 kD subunit of NADH:ubiquinone reductase - Bos taurus; localisation:mitochondrion
An18g05680	Function: the acyl-carrier protein ACP of Neurospora crassa is a subunit of NADH:ubiquinone reductase (complex I), but is also discussed to be involved in fatty acid biosynthesis as known for other soluble acyl-carrier proteins.; Phenotype: the loss of the acp-1 gene in N. crassa causes two biochemical lesions; firstly, the peripheral part of complex I is not assembled, and the membrane part is not properly assembled. Secondly, the lysophospholipid content of mitochondrial membranes is increased four-fold. In S. cerevisiae, the loss of ACP1 leads to a pleiotropic respiratory deficient phenotype.; Similarity: the predicted ORF 38 amino acids longer at the C-terminus than the N. crassa protein.; Title: strong similarity to 9.6 kD subunit of NADH:ubiquinone reductase ACP - Neurospora crassa; localisation:mitochondrion; See PMID 9175861; See PMID 1397269
An18g05690	Title: strong similarity to hypothetical protein YDR372c - Saccharomyces cerevisiae
An18g05700	Similarity: only partial similarities found.; Title: strong similarity to hypothetical protein CAD70818.1 - Neurospora crassa
An18g05720	Title: strong similarity to hypothetical protein YBR214w - Saccharomyces cerevisiae
An18g05730	Similarity: blast hits result from repetitive sequences.
An18g05740	Function: it binds directly to activated, GTP bound Arf proteins.; Function: it can alter membrane transport through the trans-Golgi.; Golgi; Localization: human protein localizes to the trans-Golgi network.; Title: similarity to ARF binding protein GGA2 - Homo sapiens; See PMID 10749927
An18g05750	Title: similarity to hypothetical protein YOR006c -Saccharomyces cerevisiae
An18g05760	Title: strong similarity to hypothetical protein SPCC1840.04 - Schizosaccharomyces pombe
An18g05770	Function: studies with S. cerevisiae conditional mutants revealed that Cct7 is required for assembly of microtubules and actin in vivo.; Title: strong similarity to component of chaperonin-containing T-complex Cct7 - Saccharomyces cerevisiae; cytoplasm; See PMID 8771707
An18g05780	Title: similarity to lanthionine synthase C-like protein 1 LANCL1 - Homo sapiens; See PMID 9512664; See PMID 10944443
An18g05800	Similarity: shows only similarity to the N-terminal aminoacids 140-280 of the human TIL4 protein.; Title: weak similarity to Toll/interleukin-1 receptor-like protein TIL4 - Homo sapiens
An18g05810	Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S26 - Homo sapiens; cytoplasm; See PMID 7945460; See PMID 8706699
An18g05820	Title: strong similarity to hypothetical protein SPAC24C9.05c - Schizosaccharomyces pombe
An18g05830	Function: the S. cerevisiae homolog is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.; Function: the S. cerevisiae homolog plays a role in protein secretion.; Title: strong similarity to protein secretion enhancer Pse-1 - Saccharomyces cerevisiae
An18g05840	Title: similarity to alcohol-acetaldehyde dehydrogenase adhE - Lactococcus lactis; See PMID 9620952
An18g05850	Title: strong similarity to hypothetical protein SPAC30C2.08 - Schizosaccharomyces pombe
An18g05860	Function: the A. alternata homologue plays an important role in the elongation step of protein synthesis. Subunit: p1 and p2 exist as dimers at the large ribosomal subunit.; Similarity: the A. alternata homologue belongs to the l12p family of ribosomal proteins.; Title: strong similarity to cytoplasmic acidic ribosomal protein p1 - Alternaria alternata; cytoplasm
An18g05870	Title: strong similarity to hypothetical membrane protein YOL092w - Saccharomyces cerevisiae
An18g05880	Function: Nulp1 from M. musculus may have a distinct role in embryonic development of many organs, including the adult brain.; Title: similarity to nucleolar protein Nulp1 - Mus musculus; nucleus; See PMID 12107429
An18g05890	Catalytic activity: [Pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [Pyruvate dehydrogenase (lipoamide)] + Orthophosphate.; Title: similarity to pyruvate dehydrogenase phosphatase isoenzyme 1 PDP1 - Rattus norvegicus; localisation:mitochondrion; See PMID 9651365
An18g05900	Function: Cox18p of S. cerevisiae is a new member of a group of mitochondrial proteins that function at a late stage of the cytochrome c oxidase assembly pathway.; Remark: the systematic genename of S. cerevisiae COX18 is YGR062C.; Title: similarity to assembly factor of cytochrome c oxidase Cox18 - Saccharomyces cerevisiae; See PMID 10809734
An18g05910	Title: strong similarity to hypothetical glycosyl transferase SPCC330.08 - Schizosaccharomyces pombe
An18g05920	Function: Crz1p in S. cerevisiae induces genes confering tolerance to high Ca2+, Mn2+, Na+, and cell wall damage.; Induction: Crz1p in S. cerevisiae is activated by the Ca2+/calmodulin binding protein phosphatase calcineurin.; Remark: CRZ1 of S. cerevisiae is also called TCN1.; Remark: the systematic name of CRZ1 from S. cerevisiae is YNL027w.; Similarity: shows strong similarity to Crz1p around the zinc-finger region and weak similarity in the glutamine-rich N-terminal region.; Title: similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; See PMID 9407035; See PMID 9407036
An18g05930	Title: questionable ORF
An18g05940	Catalytic activity: arabinogalactan endo-1,4-beta-galactosidase catalyzes the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans.; Pathway: beta-1,4-galactanase of A. aculeatus degrades unsubstituted galactan to galactose and galactobiose.; Remark: arabinogalactan endo-1,4-beta-galactosidase of A. aculeatus is also called beta-1,4-galactanase.; Similarity: nearly identical to galA of Aspergillus tubingensis, but the experimental evidence is not accessible via PubMed.; Title: strong similarity to arabinogalactan endo-1,4-beta-galactosidase gal1 - Aspergillus aculeatus; See PMID 7788716; See PMID 8520117; See PMID 10089338
An18g05960	Function: ssp1 of S. pombe is involved in the regulation of cortical actin redistribution during the change from monopolar to bipolar growth.; Title: strong similarity to serine/threonine-specific protein kinase ssp1p -Schizosaccharomyces pombe; cytoplasm; See PMID 7628434
An18g05970	Title: strong similarity to EST an_1522 -Aspergillus niger
An18g05980	Function: GTP-bound Rho1p of S. pombe binds to the amino-terminal HR-1 motifs of the protein kinase C homologs Pkc1p and Pkc2p thereby stabilizing the kinases.; Function: Rho1 is involved in actin patch localization, maintenance of cell polarity, the regulation of septation, and cell wall synthesis.; Localization: Rho1p of S. pombe is located to the peripheral membrane at the growing tips during interphase and at the septum prior to cytokinesis.; Pathway: Rho1p of S. pombe is involved in the activation of (1-3)beta-D-glucan synthase which is a key enzyme for cell wall growth.; Title: strong similarity to GTP-binding protein rho1p - Schizosaccharomyces pombe; See PMID 9372443; See PMID 9491802; See PMID 10504305; See PMID 7698654
An18g05990	Similarity: the Gly/Arg/Glu-rich domain in the N-terminal half of the ORF shares homology with a similar domain of the 70K U1 small nuclear ribonucleoprotein of Drosophila melanogaster.; Title: weak similarity to hypothetical protein SC4G6.36 - Streptomyces coelicolor
An18g06010	Remark: mitochondrial ribosomal proteins (MRPs) are the counterparts in that organelle of the cytoplasmic ribosomal proteins in the host. Although the MRPs fulfil similar functions in protein biosynthesis, they are distinct in number, features and primary structures from the latter. Most progress in the eludication of the properties of individual MRPs, and in the characterization of the corresponding genes, has been made in baker's yeast (S. cerevisiae).; Title: similarity to ribosomal protein of the large subunit Yml40 - Saccharomyces cerevisiae; See PMID 9151978; See PMID 9445368; See PMID 2060626
An18g06020	Remark: strong similarity to EST an_1617 from Aspergillus niger.; Title: strong similarity to hypothetical protein YNL206c - Saccharomyces cerevisiae
An18g06040	Remark: only repetitiv sequences are matching.; Title: weak similarity to hypothetical protein W02H5.e - Caenorhabditis elegans
An18g06050	Remark: subcellular fractionation experiments demonstrate that Cki1 and Cki2 are both cytoplasmic enzymes that do not overlap in subcellular distribution and that probably play distinct roles within the cell.; Similarity: belongs to the protein kinase family.; Title: strong similarity to casein kinase i homolog cki1p - Schizosaccharomyces pombe; See PMID 8163505
An18g06060	Title: similarity to EST an_1045 - Aspergillus niger
An18g06070	Title: questionable ORF
An18g06090	Title: similarity to EST an_3223 - Aspergillus niger
An18g06100	Title: weak similarity to hypothetical protein AAG28022.1 - Theileria parva
An18g06110	Title: strong similarity to hypothetical related a-agglutinin core protein AGA1 - Neurospora crassa
An18g06120	Remark: strong similarity to cDNA encoding human secreted protein vc33_1, SEQ ID NO:41 patent WO200011015-A1.; Title: strong similarity to secreted protein vc33_1 from patent WO200011015-A1 - Homo sapiens
An18g06130	Title: weak similarity to small subunit mitochondrial ribosomal protein Ymr31 - Saccharomyces cerevisiae
An18g06160	Function: SRB5 transcription factor that has an important role in basal and activated transcription in vitro and is essential for efficient establishment of the transcription initiation apparatus. The SRB-TBP complex binds specifically to the c-terminal domain of RNA polymerase II (ctd) in forming the transcription initiation complex. SRB2 and SRB5 are found to bind directly to TBP and are, thus, integral components of the preinitiation complex.; Title: similarity to RNA polymerase II suppressor protein Srb5 - Saccharomyces cerevisiae
An18g06170	Catalytic activity: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.; Remark: mammalian polynucleotide kinases catalyze the 5'-phosphorylation of nucleic acids and can have associated 3'-phosphatase activity, predictive of an important function in DNA repair following ionizing radiation or oxidative damage.; Title: strong similarity to polynucleotide kinase-3-phosphatase PNKP - Homo sapiens; See PMID 10446192
An18g06190	Remark: only prolin and serin are matching in the corresponding proteins.; Title: weak similarity to hypothetical proteophosphoglycan ppg3 - Leishmania major
An18g06210	Catalytic activity: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.; Pathway: urea cycle and metabolism of amino groups.; Remark: the E. coli argE-encoded N-acetyl-L-ornithine deacetylase has a relatively broad substrate specificity with a number of alpha-N-acyl-L-amino acids exhibiting activity, including both alpha-N-acetyl-and alpha-N-formylmethionine that exhibit higher activity than alpha-N-acetyl-L-ornithine.; Title: strong similarity to acetylornithine deacetylase argE - Escherichia coli; See PMID 10684608
An18g06220	Catalytic activity: hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.; Pathway: glycoprotein biosynthesis.; Remark: MNS1 is the structural gene for the specific alpha-mannosidase and its activity is not essential for viability.; Similarity: belongs to the hydrolase family 47.; Title: strong similarity to alpha-mannosidase Mns1 -Saccharomyces cerevisiae; See PMID 1714453
An18g06230	Similarity: belongs to the ATPases of the AAA+ class.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt4 - Saccharomyces cerevisiae; See PMID 10464306
An18g06240	Title: weak similarity to EST SEQ ID NO:4252 from patent WO200056762-A2 - Aspergillus niger
An18g06250	Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O; 3-phospho-D-erythronate = phosphoenol-4-deoxy-3-tetrulosonate + H2O.; Pathway: glycolysis / gluconeogenesis; phenylalanine, tyrosine and tryptophan biosynthesis.; Remark: enolase, a glycolytic enzyme that catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to form phosphoenolpyruvate (PEP), is a homodimer in all eukaryotes and many prokaryotes.; Similarity: belongs to the enolase family.; Title: strong similarity to phosphopyruvate hydratase ENO1 - Candida albicans; See PMID 8478328; See PMID 1400228
An18g06260	Remark: eukaryotic translation initiation factor 3 (eIF3) is a large multisubunit complex that plays a central role in the initiation of translation. It binds to 40 S ribosomal subunits resulting in dissociation of 80 S ribosomes, stabilizes initiator methionyl-tRNA binding to 40 S subunits, and is required for mRNA binding. eIF3 has an aggregate molecular mass of approximately 600 kDa and comprises at least 10 subunits.; Title: similarity to eukaryotic translation initiation factor eIF3 subunit p35 - Homo sapiens; See PMID 9822659
An18g06270	Function: over-expression of artA in A. nidulans causes a severe delay in the polarization of conidiospores.; Title: strong similarity to 14-3-3 protein homolog artA - Aspergillus nidulans; See PMID 12023078
An18g06290	Similarity: A. niger EST EMBLEST:BE760558 covers part of exon 4, confirms the structure of exon5, and contains part of the putative 3'UTR of the gene.; Similarity: interestingly, the predicted ORF, as well as nca-1 of N. crassa, show much stronger similarity to these animal-type Ca2+ pumps than to the plant or yeast homologues (as e. g. S. cerevisiae ENA5).; Similarity: the predicted ORF is about 75% identical to the N. crassa nca-1; the function of this enzyme is poorly characterized.; Similarity: the predicted ORF shows very strong similarity to a panoply of animal P-type sarco-endoplasmic reticulum Ca2+ ATPases, all required to sequester Ca2+ from the cytoplasm into the ER, thus providing the intracellular Calcium dynamic homeostasis required for most cellular physiological responses in a variety of biological processes.; Title: strong similarity to calcium P-type ATPase nca-1 - Neurospora crassa; See PMID 10712689; See PMID 11302372; See PMID 11389677; See PMID 1384045
An18g06310	Function: fucP in E. coli is the L-fucose (6-deoxy-L-galactose) - H+ symporter required for import of L-fucose from the extracellular environment.; Similarity: within the large superfamily of Major Facilitators, the FucP protein of E. coli, together with few similar bacterial proteins, constitute a peculiar small subgroup of transport proteins, displaying few structural similarity to other transporters.; Title: strong similarity to L-fucose permease fucP -Escherichia coli; plasma membrane; See PMID 8052131; See PMID 2553671; See PMID 2664711
An18g06320	Function: MARKs phosphorilate and modulate tau, MAP2 and MAP4, major regulators of microtubule polymerization and organization within the cell.; Similarity: in particular it shows a strong similarity to MARK-1 and -2 of different mammals.; Similarity: the predicted ORF shows strong similarity and the typical domains of several known and putative protein Ser/Thr kinases.; Title: strong similarity to serine/threonine kinase MARK2 - Rattus norvegicus; See PMID 9108484; See PMID 10737602
An18g06330	Title: questionable ORF
An18g06340	Catalytic activity: 2 Geranylgeranyl diphosphate = Pyrophosphate + Prephytoene diphosphate.; Function: the R. norvegicus protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a carboxyl-terminal CAAX (C, cysteine; A, aliphatic amino acid; X, any amino acid) motif in which the 'X' residue is leucine.; Remark: the co-expression of the GGTase-I beta subunit cDNA from R. norvegicus together with the alpha subunit of protein farnesyltransferase in E. coli produced recombinant GGTase-I with electrophoretic and enzymatic properties indistinguishable from native GGTase-I.; Title: strong similarity to geranylgeranyl diphosphate geranylgeranyltransferase I beta chain GGTase-I - Rattus norvegicus; See PMID 8106351
An18g06360	Induction: CSA1 from C. albicans is preferentially expressed during the mycelial growth phase, although a low level of CSA1 mRNA can be detected in the yeast form.; Localization: Csa1 from C. albicans is not randomly distributed over the surface of yeast cells, but localizes predominantly in the growing buds.; Similarity: the ORF also shows strong similarity to the EST an_2742 from Aspergillus niger.; Title: similarity to mycelial surface antigen Csa1 -Candida albicans; plasma membrane; See PMID 10652105
An18g06370	Function: Hol1 from S. cerevisiae is a member of the major facilitator transporter family.; Phenotype: mutations in the hol1 gene of S. cerevisiae permit growth of histidine auxotrophs cells on histidinol, the biosynthetic precursor to histidine, by enhancing the ability of cells to take up histidinol from the medium.; Remark: the synonym for Hol1 from S. cerevisiae is YNR055c.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 2405251; See PMID 8955402
An18g06380	Similarity: the ORF is much shorter than FmtB of S. aureus (246 compared to 1795 amino acids); the alignment between these two proteins encompasses only about 80 amino acids.; Title: weak similarity to protein involved in methicillin resistance FmtB - Staphylococcus aureus; See PMID 10896508
An18g06390	Similarity: the similarities to lower scored matches are mainly based on repetetive structures.; Title: strong similarity to hypothetical conserved protein encoded by B2F7.170 - Neurospora crassa
An18g06400	Title: weak similarity to protein-tyrosine phosphatase ptp - Clostridium perfringens
An18g06410	Title: strong similarity to hypothetical conserved protein encoded by B2F7.030 - Neurospora crassa
An18g06430	Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to chorion gene s18 -Ceratitis capitata
An18g06440	Localization: Yip3 is selectively and efficiently packaged into COPII vesicles.; Remark: cytosolic coat proteins (COPII) direct the formation of transport vesicles.; Remark: the synonym for Yip3 from S. cerevisiae is YNL044w.; Title: strong similarity to COPII vesicle component Yip3 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11157978
An18g06450	Title: weak similarity to hypothetical protein L5515.05 - Leishmania major
An18g06460	Title: weak similarity to calcium channel BI-2 -Oryctolagus cuniculus
An18g06470	Function: Mtj1 from M. musculus stimulates the ATPase activity of the Hsp70 family member BiP/GRP78 at stoichiometric concentrations.; Induction: Mtj1 from M. musculus is enriched in the nuclear and heavy microsome subcellular fractions of murine tumor cells.; Title: strong similarity to DnaJ-like protein MTJ1 -Mus musculus; See PMID 10777498; See PMID 7875597
An18g06490	Induction: heat shock applied on C. curvatus for 1 h resulted in a pronounced but transient increase of the SIS1 mRNA.; Remark: Cryptococcus curvatus = Apiotrichum curvatum.; Remark: separated by a sucrose gradient Sis1 from C. curvatus was found in fractions together with ribosomes and with Hsp70.; Title: similarity to ribosome-associated DnaJ protein Sis1 - Cryptococcus curvatus; cytoplasm; See PMID 9559550
An18g06500	Catalytic activity: D-Mannose 1-phosphate = D-Mannose 6-phosphate.; Cofactor: D-Mannose 1,6-bisphosphate, D-Glucose 1,6-bisphosphate.; Function: Sec53 from S. cerevisiae is required for completion of assembly of proteins in the endoplasmic reticulum in yeast.; Function: Sec53 from S. cerevisiae is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.; Function: a sec53 mutant of S. cerevisiae is not defective in translocation, rather in assembly of the dolichol-oligosaccharide substrate needed for N-linked glycosylation.; Function: the secretory defect in phosphomannomutase sec53 cells of S. cerevisiae may be explained by a deficit in GDP-mannose production.; Localization: Sec53 protein from S. cerevisiae is associated with the cytoplasmic surface of the endoplasmic reticulum membrane.; Phenotype: precursors to exported proteins become firmly attached to the endoplasmic reticulum membrane and are not released into the lumen in a soluble form.; Remark: synonyms for Sec53 from S. cerevisiae are Alg4 and YFL045c.; Similarity: the ORF also shows strong similarity to the EST an_3165 from Aspergillus niger.; Title: strong similarity to phosphomannomutase Sec53 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 3046935; See PMID 3288631; See PMID 3298255; See PMID 3317409
An18g06510	Phenotype: a rad5 mutant of A. thaliana is blocked at a step in the transformation process prior to T-DNA integration following the transformation by Agrobacterium tumefaciens.; Phenotype: the Arabidopsis rad5 mutant is phenotypically similar to mutants in the RAD52 epistasis group of S. cerevisiae, which are highly sensitive to ionizing radiation but not hypersensitive to UV light.; Title: strong similarity to DNA repair protein RAD5 - Arabidopsis thaliana; nucleus; See PMID 9805401; See PMID 8028582
An18g06520	Function: Ecm29 from S. cerevisiae is involved in cell wall biogenesis and architecture.; Phenotype: the ecm29 mutant of S. cerevisiae is hypersensitive to calcofluor white and zymolyase but is resistant to hygromycin B.; Remark: the synonym for Ecm29 from S. cerevisiae is YHL030w.; Title: strong similarity to protein involved in cell wall biogenesis and architecture Ecm29 - Saccharomyces cerevisiae; See PMID 9335584
An18g06530	Title: weak similarity to beta V spectrin BSPECV -Homo sapiens
An18g06540	putative frameshift
An18g06560	Remark: C-terminal truncated ORF due to end of contig.; Title: strong similarity to putative signalling cascade component protein pro40 - Sordaria macrospora [truncated ORF]
An18g06570	Remark: the ORF is N-terminally truncated due to the contig border.; Remark: the ORF shows strong similarity to the hypothetical membrane protein YGR266w from S. cerevisiae but no transmembrane domain was predicted for the ORF.; Title: strong similarity to hypothetical protein YGR266w - Saccharomyces cerevisiae [truncated ORF]; See PMID 9605509
An18g06580	Phenotype: in a Y. lipolytica lip2 knockout (KO) strain no extracellular lipase activity was detected.; Similarity: the A. niger EST an_2774 in EMBLEST:BE759847 overlaps with the ORF.; Similarity: the ORF has a local N-terminal strong similarity to the lip2 protein of Y. lipolytica (ending at amino acid 306 of the ORF).; Similarity: the predicted ORF shows similarity to esterases of various Aspergillus species and with different cellular functions.; Title: strong similarity to triacylglycerol lipase Lip2 - Yarrowia lipolytica; See PMID 10781549
An18g06590	Complex: biochemical analyses demonstrate that sop2 protein of S. pombe is present in a complex which also contains the actin-related protein, Arp3p.; Function: sop2 protein of S. pombe modulates profilin and is part of a complex implicated in the control of actin polymerization.; Localization: immunofluorescence studies reveal the presence of sop2 protein of S. pombe in punctate structures distributed throughout the cell, cables that extend the length of the cell, and a medial band in a small percentage of septating cells.; Phenotype: S. pombe sop2 mutant is defective for cell elongation and septation.; Title: strong similarity to Arp2/3 complex subunit sop2p - Schizosaccharomyces pombe
An18g06600	Similarity: the ORF is C-terminally shorter than snRNP U2B'' of H. sapiens (47 amino acids).; Title: strong similarity to small nuclear ribonucleoprotein U2B snRNP U2B - Homo sapiens; See PMID 10648562; See PMID 2951739
An18g06620	Remark: unusual exon/intron structure for A. niger.; Title: questionable ORF
An18g06630	Remark: short length for A. niger ORFs (125 amino acids).
An18g06650	Induction: Northern blot hybridization indicated that the expression of the hsp30 gene of A. nidulans was high at a normal temperature and was slightly accelerated at elevated temperatures in A. nidulans cells.; Title: strong similarity to heat shock protein hsp30 - Aspergillus nidulans; See PMID 7918658; See PMID 11482349
An18g06660	Title: strong similarity to hypothetical protein SPAC664.12c - Schizosaccharomyces pombe
An18g06670	Title: strong similarity to hypothetical 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase BH2000 -Bacillus halodurans
An18g06680	Catalytic activity: the PRE4 gene of S. cerevisiae is necessary for peptidylglutamyl-peptide-hydrolyzing activity.; Complex: PRE4 protein of S. cerevisiae is a subunit of the yeast proteasome, proteinase yscE.; Function: the PRE4 protein of S. cerevisiae is involved in ubiquitin-dependent protein degradation.; Phenotype: chromosomal deletion of the PRE4 gene of S. cerevisiae is lethal.; Phenotype: pre1-1 (mutation in the gene responsible for the chymotrypsin-like activity) and pre4-1 S. cerevisiae double mutants showed enhanced canavanine sensitivity and increased accumulation of ubiquitin protein conjugates, as compared with pre1-1 single mutants.; Title: strong similarity to proteasome 20S subunit Pre4 - Saccharomyces cerevisiae; See PMID 8381431
An18g06690	Similarity: the ORF is N-terminally longer than the hypothetical protein of S. pombe (70 amino acids).; Similarity: the ORF shows weak similarity to transcriptional regulator protein HCNGP of H. sapiens and M. musculus.; Title: similarity to hypothetical protein SPAC3H1.03 - Schizosaccharomyces pombe
An18g06700	Complex: the PRE7 protein of S. cerevisiae is a subunit of the 20S core proteasome.; Phenotype: chromosomal disruption of the PRE7 gene of S. cerevisiae creates a recessive lethal mutation.; Remark: PRE7 of S. cerevisiae is also called PTS1,YBL041W, YBL0407 or PRS3, which is now used for a ribose-phosphate pyrophosphokinase of S. cerevisiae.; Remark: the 20 S proteasome is the proteolytic core of the 26 S proteasome, the central protease involved in ubiquitin-mediated protein degradation in eukaryotes.; Similarity: the A. niger EST clone 2974 in EMBLEST:BE760015ORF overlaps with the ORF.; Title: strong similarity to proteasome 20S subunit Pre7 - Saccharomyces cerevisiae; See PMID 10500111; See PMID 1734860
An18g06710	Title: strong similarity to hypothetical protein YOR3513c - Saccharomyces cerevisiae
An18g06720	Title: strong similarity to hypothetical protein YHR194w - Saccharomyces cerevisiae
An18g06730	Remark: the putative A. niger protein is 1000 amino acids longer than human Rlip76.; Title: similarity to GTPase-activating protein RLIP76 - Homo sapiens; similarity: the putative A. niger protein shows similarity to different GTPase-activating proteins.; See PMID 7673236
An18g06740	Similarity: the A. niger ORF shows strong similarity to EST an_0449 of A. niger; Similarity: the A. niger portein also shows weak similarity to the rat steroidogenic acute regulatory protein.; Title: strong similarity to hypothetical protein YHR181w - Saccharomyces cerevisiae
An18g06750	Function: S-adenosyl-L-methyltransferases are involved in transferring methylgroups to a variety of target molecules.; Remark: the S-adenosyl-L-methyltransferase from patent US5876996-A is not properly described.; Title: strong similarity to S-adenosyl-L-methyltransferase from patent US5876996-A -Homo sapiens
An18g06760	Catalytic activity: isocitrate dehydrogenases catalyze the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.; Remark: Histoplasma capsulatum is an alternative name for A. capsulatus .; Remark: isocitrate dehydrogenase from S. cerevisiae is composed of two nonidentical subunits, IDH1 and IDH2.; Remark: isocitrate dehydrogenase subunit I from can rescue the idh1 mutant of S. cerevisiae.; Title: strong similarity to NAD(+)-isocitrate dehydrogenase subunit I idh1 - Ajellomyces capsulatus; localisation:mitochondrion; See PMID 10398348
An18g06780	Title: similarity to hypothetical protein B1O14.080 - Neurospora crassa
An18g06800	Complex: the PRE10 protein of S. cerevisiae is the alpha7 subunit of the 20S core proteasome.; Function: the 20 S proteasome is the proteolytic core of the 26 S proteasome, the central protease involved in ubiquitin-mediated protein degradation in eukaryotes.; Remark: PRS1, YC1 and PRC1 are alternative gene names for PRE10; Title: strong similarity to proteasome 20S subunit Pre10 - Saccharomyces cerevisiae; See PMID 1697860
An18g06810	Complex: RIB4 from S. cerevisiae forms a pentamer in vivo.; Pathway: RIB4 from S. cerevisiae is involved in the biosynthesis of riboflavin.; Phenotype: yeast rib4 mutants are auxotrophic for riboflavin.; Title: similarity to 6,7-dimethyl-8-ribityllumazine synthase Rib4 - Saccharomyces cerevisiae; See PMID 7559556
An18g06820	Catalytic activity: Gfa1p of S. cerevisiae catalyzes the formation of D-glucosamine-6-phosphate from the amido group of L-glutamine and fructose-6-phosphate: L-glutamine + D-fructose-6-phosphate <=> L-glutamate + D-glucosamine-6-phosphate.; Function: Gfa1p of S. cerevisiae is involved in the first step of the hexosamine pathway required for biosynthesis of cell wall precursors.; Induction: the glutamine--fructose-6-phosphate amidotransferase activity of gfa1 from S. cerevisiae increases 1. 7-fold after alpha factor addition.; Induction: the promotor region of the S. cerevisiae gfa1 gene contains six repeats of the heptanucleotide TGAAACA, which was shown to be required for pheromone control of transcription.; Remark: a splice site was detected upstream of the START codon.; Remark: glucosamine-6-phosphate is used in the biosynthesis of amino sugars of asparagine-linked oligosaccharide chains in glycoproteins.; Title: strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 -Saccharomyces cerevisiae; cytoplasm; See PMID 2656689
An18g06830	Title: questionable ORF
An18g06840	Phenotype: mutant human trithorax leads to leukemia.; Similarity: the A. niger protein also shows similarity to other trithorax like proteins.; Title: similarity to trithorax protein All1 - Homo sapiens; nucleus; See PMID 1303259; See PMID 1423624
An18g06850	Remark: the A. niger protein also shows similarity to human prostate tumor EST fragment derived protein #79 from patent DE19820190-A1. The function of this protein has not been described.; Title: strong similarity to hypothetical conserved protein SPAC31A2.02 - Schizosaccharomyces pombe